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Publications (125)636.71 Total impact
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ABSTRACT: We investigated the course of decline in multiple cognitive domains in non-demented subjects from a memory clinic setting, and compared pattern, onset and magnitude of decline between subjects who progressed to Alzheimer's disease (AD) dementia at follow-up and subjects who did not progress. In this retrospective cohort study 819 consecutive non-demented patients who visited the memory clinics in Maastricht or Amsterdam between 1987 and 2010 were followed until they became demented or for a maximum of 10 years (range 0.5-10 years). Differences in trajectories of episodic memory, executive functioning, verbal fluency, and information processing speed/attention between converters to AD dementia and subjects remaining non-demented were compared by means of random effects modelling. The cognitive performance of converters and non-converters could already be differentiated seven (episodic memory) to three (verbal fluency and executive functioning) years prior to dementia diagnosis. Converters declined in these three domains, while non-converters remained stable on episodic memory and executive functioning and showed modest decline in verbal fluency. There was no evidence of decline in information processing speed/attention in either group. Differences in cognitive performance between converters to AD dementia and subjects remaining non-demented could be established 7 years prior to diagnosis for episodic memory, with verbal fluency and executive functioning following several years later. Therefore, in addition to early episodic memory decline, decline in executive functions may also flag incident AD dementia. By contrast, change in information processing speed/attention seems less informative.Psychological Medicine 11/2014; · 5.43 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background: The involvement of frontostriatal circuits in frontotemporal dementia (FTD) suggests that deep gray matter structures (DGM) may be affected in this disease. Objective: We investigated whether volumes of DGM structures differed between patients with behavioral variant FTD (bvFTD), Alzheimer's disease (AD), and subjective complaints (SC) and explored relationships between DGM structures, cognition, and neuropsychiatric functioning. Methods: For this cross-sectional study, we included 24 patients with FTD and matched them based on age, gender, and education at a ratio of 1:3 to 72 AD patients and 72 patients with SC who served as controls. Volumes of hippocampus, amygdala, thalamus, caudate nucleus, putamen, globus pallidus, and nucleus accumbens were estimated by automated segmentation of 3D T1-weighted MRI. MANOVA with Bonferroni adjusted post-hoc tests was used to compare volumes between groups. Relationships between volumes, cognition, and neuropsychiatric functioning were examined using multivariate linear regression and Spearman correlations. Results: Nucleus accumbens and caudate nucleus discriminated all groups, with most severe atrophy in FTD. Globus pallidus volumes were smallest in FTD and discriminated FTD from AD and SC. Hippocampus, amygdala, thalamus, and putamen were smaller in both dementia groups compared to SC. Associations between amygdala and memory were found to be different in AD and FTD. Globus pallidus and nucleus accumbens were related to attention and executive functioning in FTD. Conclusion: Nucleus accumbens, caudate nucleus, and globus pallidus were more severely affected in FTD than in AD and SC. The associations between cognition and DGM structures varied between the diagnostic groups. The observed difference in volume of these DGM structures supports the idea that next to frontal cortical atrophy, DGM structures, as parts of the frontal circuits, are damaged in FTD rather than in AD.Journal of Alzheimer's disease: JAD 10/2014; · 3.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To investigate trajectories of cognitive decline in patients with different types of dementia compared to controls in a longitudinal study.Psychological Medicine 09/2014; · 5.43 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We aimed to assess the impact of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease on decision making and patient management in a tertiary memory clinic.Alzheimer's & dementia: the journal of the Alzheimer's Association 08/2014; · 14.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Genetic factors are important in all forms of dementia, especially in early onset dementia. The frequency of major gene defects in dementia has not been investigated in the Netherlands. Furthermore, whether the recently in a FTD family identified PRKAR1B gene is associated with an Alzheimer's disease (AD) like phenotype, has not been studied. With this study, we aimed to investigate the mutation frequency of the major AD and FTD genes and the PRKAR1B gene in a well-defined Dutch cohort of patients with early onset dementia. Mutation analysis of the genes PSEN1, APP, MAPT, GRN, C9orf72 and PRKAR1B was performed on DNA of 229 patients with the clinical diagnosis AD and 74 patients with the clinical diagnosis FTD below the age of 70 years. PSEN1 and APP mutations were found in, respectively 3.5 and 0.4 % of AD patients, and none in FTD patients. C9orf72 repeat expansions were present in 0.4 % of AD and in 9.9 % of FTD patients, whereas MAPT and GRN mutations both were present in 0.4 % in AD patients, and in 1.4 % resp. 2.7 % in FTD patients. We did not find any pathogenic mutations in the PRKAR1B gene. PSEN1 mutations are the most common genetic cause in Dutch AD patients, whereas MAPT and GRN mutations were found in less than 5 percent. C9orf72 repeat expansions were the most common genetic defect in FTD patients. No pathogenic PRKAR1B mutations were found in the early onset AD and FTD patients of our study.Journal of Neurology 08/2014; · 3.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To compare pseudo-continuous arterial spin-labelled (PCASL) magnetic resonance imaging (MRI) measured quantitative cerebral blood flow (CBF) of patients with frontotemporal dementia (FTD), dementia with Lewy Bodies (DLB), Alzheimer's disease (AD) and controls, in a region of interest (ROI) and voxel-wise fashion.European radiology. 07/2014; - [Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72-have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. METHODS: We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. To reduce genetic heterogeneity, all participants were of European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10(-8)) single-nucleotide polymorphisms. FINDINGS: We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10(-8)). Combined (joint) analyses of discovery and replication phases showed genome-wide significant association at 6p21.3, HLA locus (immune system), for rs9268877 (p=1·05 × 10(-8); odds ratio=1·204 [95% CI 1·11-1·30]), rs9268856 (p=5·51 × 10(-9); 0·809 [0·76-0·86]) and rs1980493 (p value=1·57 × 10(-8), 0·775 [0·69-0·86]) in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC (the transcripts of which are related to lysosomal biology), for the behavioural FTD subtype for which joint analyses showed suggestive association for rs302668 (p=2·44 × 10(-7); 0·814 [0·71-0·92]). Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation in cis. INTERPRETATION: Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and to shed light on the pathomechanisms contributing to FTDThe Lancet Neurology 07/2014; 3(7):686-99. · 21.82 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Co-morbidity and frailty are common in Alzheimer's disease (AD) and may contribute to the heterogeneity in clinical manifestations of the disease. We cross-sectionally investigated whether co-morbidity and frailty were independently associated with the clinical manifestation of AD in the 4C-Dementia study; a multicenter, longitudinal study in newly diagnosed AD patients. Clinical manifestation was operationalized using a composite of cognitive performance (neuropsychological assessment), activities of daily living functioning (Disability Assessment for Dementia; DAD) and neuropsychiatric symptoms (Neuropsychiatric Inventory). As predictors of prime interest, co-morbidity was determined using the Cumulative Illness Rating Scale (CIRS-G) and frailty by the Fried criteria. In total, 213 AD patients participated (mean age 75 ± 10 years; 58% females). In linear regression models adjusted for age, gender, education, and disease duration, CIRS-G (β = -0.21, p < 0.01) and frailty (β = -0.34, p < 0.001) were separately associated with clinical AD manifestation. However, CIRS-G (β = -0.12, p = 0.12) lost statistical significance when both were combined (frailty: β = -0.31, p < 0.001). Models with the individual components of clinical AD manifestation as dependent variables show significant associations between cognitive performance and CIRS-G (β = -0.22, p = 0.01), and between DAD and frailty (β = -0.37, p < 0.001). Our findings indicate that physical health and clinical AD manifestation are associated. This association may be responsible for part of the heterogeneity in the presentation of AD. This emphasizes the importance of adequate assessment of co-morbid medical conditions and frailty in participants with AD.Journal of Alzheimer's disease: JAD 06/2014; · 3.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Since its opening in 2000, patient care and research go hand in hand at the Alzheimer center of the VU University Medical Center, both organized in such a way that they mutually strengthen each other. Our mission is to give patients a voice by lifting the stigma on dementia, to find new diagnostic and treatment strategies, and, ultimately, to cure diseases that cause dementia. Our healthcare pathway is uniquely designed to accommodate all necessary investigations for the diagnostic work-up of dementia in one day (one-stop shop). A second unique feature is that research has been fully integrated in the healthcare pathway. The resulting Amsterdam Dementia Cohort now includes over 4000 patients, and for the majority of these, we have MRI, EEG, blood (serum, plasma), DNA, and CSF available. The Amsterdam Dementia Cohort forms the basis of much of our research, which focuses on four major research lines: 1) variability in manifestation, 2) early diagnosis, 3) vascular factors, and 4) interventions. By answering research questions closely related to clinical practice, the results of our research can be looped back to improve clinical work-up for our patients.Journal of Alzheimer's disease: JAD 03/2014; · 3.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Aim: To assess the reliability and validity of the Van Heugten test for apraxia (VHA), developed for and used in stroke patients, in a memory clinic population. Furthermore, we assess the presence and severity of apraxia in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and investigate which AD patients are likely to develop apraxia. Methods: We included 90 controls (age: 60 ± 9 years, MMSE: 28 ± 2), 90 MCI patients (age: 65 ± 7 years, MMSE: 26 ± 2) and 158 AD patients (age: 66 ± 8 years, MMSE: 20 ± 5). Apraxia was evaluated by the VHA assessing ideational and ideomotor praxis. We retested 20 patients to assess reliability. Results: Intrarater reliability was 0.88 and interrater reliability was 0.73. AD patients performed worse on the VHA (median: 88; range: 51-90) than controls (median: 90; range: 88-90) and MCI patients (median: 89; range: 84-90) (both p < 0.001). Apraxia was prevalent in 35% of AD patients, in 10% of MCI and it was not observed in controls (0%; p < 0.001). In AD, dementia severity was the main risk for apraxia; 15% of mildly versus 52% of moderately demented patients had apraxia (OR = 6.7, 95% CI 2.9-15.6). The second risk factor was APOE genotype. APOE ε4 noncarriers (47%) were at increased risk compared to carriers (30%) (OR = 2.1, 95% CI 1-4.7). Conclusion: Apraxia can be reliably measured with the VHA and is present in a proportion of patients with MCI and AD. The presence of apraxia in AD is related to dementia severity and APOE ε4. © 2014 S. Karger AG, Basel.Dementia and Geriatric Cognitive Disorders 03/2014; 38(1-2):55-64. · 2.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Characteristic frontotemporal abnormalities on structural or functional neuroimaging are mandatory for a diagnosis of probable behavioral variant of frontotemporal dementia (bvFTD) according to the new criteria. 18-Fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) imaging is commonly reserved for patients with suspected bvFTD without characteristic structural neuroimaging results. We studied the diagnostic value of 18F-FDG-PET in these patients.Methods:The 18F-FDG-PET was performed in 52 patients with suspected bvFTD but lacking characteristic structural neuroimaging results. The clinical diagnosis of bvFTD in the presence of functional decline (bvFTD/fd+) after a follow-up period of 2 years was used as a golden standard.Results:The sensitivity of 18F-FDG-PET for bvFTD/fd+ was 47% at a specificity of 92%. The differential diagnosis comprised alternative neurodegenerative and psychiatric disorders and a benign phenocopy of bvFTD.Conclusions:The 18F-FDG-PET is able to identify nearly half of the patients with bvFTD who remain undetected by magnetic resonance imaging. In our selected group, high specificity enables exclusion of psychiatric and other neurodegenerative disorders.American Journal of Alzheimer s Disease and Other Dementias 02/2014; · 1.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Measuring impairments in "instrumental activities of daily living" (IADL) is important in dementia, but challenging due to the lack of reliable and valid instruments. We recently developed the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q; note 1). We aim to investigate the diagnostic accuracy of the A-IADL-Q for dementia in a memory clinic setting. Patients visiting the Alzheimer Center of the VU University Medical Center with their informants between 2009 and 2011 were included (N = 278). Diagnoses were established in a multidisciplinary consensus meeting, independent of the A-IADL-Q scores. An optimal A-IADL-Q cutoff point was determined, and sensitivity and specificity were calculated. Area under the curves (AUCs) were compared between A-IADL-Q and "disability assessment of dementia" (DAD). The additional diagnostic value of the A-IADL-Q to Mini-Mental State Examination (MMSE) was examined using logistic regression analyses. Dementia prevalence was 50.5%. Overall diagnostic accuracy based on the AUC was 0.75 (95% confidence interval [CI]: 0.70-0.81) for the A-IADL-Q and 0.70 (95% CI: 0.63-0.77) for the DAD, which did not differ significantly. The optimal cutoff score for the A-IADL-Q was 51.4, resulting in sensitivity of 0.74 and specificity of 0.64. Combining the A-IADL-Q with the MMSE improved specificity (0.94), with a decline in sensitivity (0.55). Logistic regression models showed that adding A-IADL-Q improved the diagnostic accuracy (Z = 2.55, P = .011), whereas the DAD did not. In this study, we showed a fair diagnostic accuracy for A-IADL-Q and an additional value in the diagnosis of dementia. These results support the role of A-IADL-Q as a valuable diagnostic tool.Journal of Geriatric Psychiatry and Neurology 12/2013; 26(4):244-50. · 1.63 Impact Factor -
Article: Regional atrophy is associated with impairment in distinct cognitive domains in Alzheimer's disease.
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ABSTRACT: In Alzheimer's disease (AD), some patients present with cognitive impairment other than episodic memory disturbances. We evaluated whether occurrence of posterior atrophy (PA) and medial temporal lobe atrophy (MTA) could account for differences in cognitive domains affected. In 329 patients with AD, we assessed five cognitive domains: memory, language, visuospatial functioning, executive functioning, and attention. Magnetic resonance imaging (MRI) was rated visually for the presence of MTA and PA. Two-way analyses of variance were performed with MTA and PA as independent variables, and cognitive domains as dependent variables. Gender, age, and education were covariates. As PA is often encountered in younger patients, analyses were repeated after stratification for age of onset (early onset, ≤ 65 years). The mean age of the participants was 67 years, 175 (53%) were female, and the mean Mini-Mental State Examination (score ± standard deviation) was 20 ± 5 points. Based on dichotomized magnetic resonance imaging ratings, 84 patients (26%) had MTA and PA, 98 (30%) had MTA, 57 (17%) had PA, and 90 (27%) had neither. MTA was associated with worse performance on memory, language, and attention (all, P < .05), and PA was associated with worse performance on visuospatial and executive functioning (both, P < .05). Stratification for age showed in patients with late-onset AD (n = 173) associations between MTA and impairment on memory, language, visuospatial functioning, and attention (all, P < .05); in early-onset AD (n = 156), patients with PA tended to perform worse on visuospatial functioning. Regional atrophy is related to impairment in specific cognitive domains in AD. The prevalence of PA in a large set of patients with AD and its association with cognitive functioning provides support for the usefulness of this visual rating scale in the diagnostic evaluation of AD.Alzheimer's & dementia: the journal of the Alzheimer's Association 11/2013; · 14.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: ABSTRACT Background: Little is known about care needs in young-onset dementia (YOD) patients, even though this information is essential for service provision and future care planning. We explored: (1) care needs of people with YOD, (2) the level of agreement within patient-caregiver dyads on care needs, and (3) the longitudinal relationship between unmet needs and neuropsychiatric symptoms. Methods: A community-based prospective study of 215 YOD patients-caregiver dyads. Care needs were assessed with the Camberwell Assessment of Need for the Elderly. The level of agreement between patient and caregivers' report on care needs was calculated using κ coefficients. The relationship between unmet needs and neuropsychiatric symptoms over time, assessed with the Neuropsychiatric Inventory, was explored using linear mixed models. Results: Patients and caregivers generally agreed on the areas in which needs occurred. Only modest agreement existed within patient-caregiver dyads regarding whether needs could be met. Patients experienced high levels of unmet needs in areas such as daytime activities, social company, intimate relationships, and information, leading to an increase in neuropsychiatric symptoms. Conclusions: Our findings indicate that in YOD, there are specific areas of life in which unmet needs are more likely to occur. The high proportions of unmet needs and their relationship with neuropsychiatric symptoms warrant interventions that target neuropsychiatric symptoms as well as the prevention of unmet needs. This underlines the importance of the periodic investigation of care needs, in which patient and caregiver perspectives are considered complementary.International Psychogeriatrics 09/2013; · 1.89 Impact Factor -
Article: Progression to dementia in memory clinic patients without dementia: A latent profile analysis.
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ABSTRACT: To identify the existence of discrete cognitive subtypes among memory clinic patients without dementia and test their prognostic values. In a retrospective cohort study of 635 patients without dementia visiting the Alzheimer centers in Maastricht or Amsterdam, latent profile analysis identified cognitive subtypes based on immediate and delayed memory recall, delayed recognition, information-processing speed, attention, verbal fluency, and executive functions. Time to dementia was tested in weighted Cox proportional hazard models adjusted for confounders. Five latent classes represented participants with high-normal cognition (15%), low-normal cognition (37%), primary memory impairment in recall (MI) (36%), memory impairment in recall and recognition (MI+) (5%), and primary nonmemory impairment (NMI) (6%). Compared with low-normal cognition, participants with NMI had the highest risk of dementia (hazard ratio [HR] = 5.94, 95% confidence interval [CI] = 3.46-10.18) followed by MI (HR = 3.05, 95% CI = 2.09-4.46) and MI+ (HR = 3.26, 95% CI = 1.72-6.17), while participants with high-normal cognition had the lowest risk (HR = 0.24, 95% CI = 0.07-0.80). Subtypes further showed differential relationships with dementia types, with MI and MI+ most often converting to Alzheimer-type dementia and NMI to other forms of dementia. Cognitive subtypes can be empirically identified in otherwise heterogeneous samples of memory clinic patients and largely confirm current strategies to distinguish between amnestic and nonamnestic impairment. Studying more homogeneous cognitive subtypes may improve understanding of disease mechanisms and outcomes.Neurology 08/2013; · 8.30 Impact Factor -
Dataset: ALS-FTD-Questionnaire
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ABSTRACT: Young-onset dementia (YOD) causes specific challenges and issues that are likely to affect health-related quality of life (HRQOL). This study explored patient and caregiver HRQOL and its association with unmet needs in YOD. A cross-sectional design was used to study 215 community-dwelling YOD patients and their primary caregivers. Multiple linear regression analyses were performed to determine the relationship between unmet needs assessed with the Camberwell Assessment of Need for the Elderly scale and patient and caregiver HRQOL, controlling for other variables such as demographic characteristics, patient functional status, neuropsychiatric symptoms, and caregiver sense of competence. Patient HRQOL was not associated with unmet needs. However, we found that the unmet needs of both patient and caregiver were related to several domains of caregiver HRQOL. This study shows that patient and caregiver unmet needs are related to caregiver HRQOL in YOD. However, the relationship between HRQOL and unmet needs is complex. The assessment of unmet needs within the context of HRQOL seems to be an important prerequisite for personalizing care in YOD. Adjusting supportive services to match the individual needs and preferences of these young patients and their caregivers is likely to enhance their quality of life.The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry 07/2013; · 3.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia. The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up. The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up. This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry 06/2013; · 3.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background: This study describes the validation of a new instrument measuring instrumental activities of daily living (IADL), the Amsterdam IADL Questionnaire© (a registered copyright of the Alzheimer Center of the VU University Medical Center). This informant-based tool aimed at detecting IADL problems in incipient dementia was previously found to have a high internal consistency and test-retest reliability. Methods: Patients and their informants who visited the Alzheimer Center of the VU University Medical Center were included in this study. Item response theory was used to estimate the individuals' trait levels as a measure of IADL disability. Construct validity was tested by correlating estimated trait levels with clinical and demographic measures using Pearson's or Kendall's τ correlation coefficients. Additionally, estimated trait levels between patients with and without dementia and between patients with early- and late-onset dementia were compared using independent t tests. Results: A total of 206 informants of patients completed the Amsterdam IADL Questionnaire. The correlations between estimated trait levels and other measures were in concordance with previously formed hypotheses. Patients diagnosed with dementia (n = 93) had higher estimated trait levels than patients without dementia (n = 96), Cohen's effect size, d = 1.04, t(187) = 7.1, p < 0.001. We found no differences between early- and late-onset dementia patients. Conclusions: Results suggest that the Amsterdam IADL Questionnaire is a reliable and valid instrument in the evaluation of dementia.Neuroepidemiology 05/2013; 41(1):35-41. · 2.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We present the case of a 52-year-old man who was diagnosed with the behavioural variant of frontotemporal dementia (bvFTD) in accordance with consortium criteria from 1998. The diagnosis was questioned in the years of follow-up, since neuroimaging showed no abnormalities and no deterioration of clinical symptoms was seen. After 3 years, the diagnosis was withdrawn after the psychiatrist concluded that his low intelligence, combined with a cluster C personality and relational problems, had caused his altered behaviour. Diagnosing bvFTD is challenging because of its clinical resemblance to neurodegenerative and psychiatric illnesses. The new bvFTD consortium criteria from 2011 emphasize the importance of distinguishing possible and probable bvFTD. This can reduce the number of incorrect diagnoses. We present a flow chart based on these criteria, which could aid in improving the diagnostic process.Nederlands tijdschrift voor geneeskunde 01/2013; 157(42):A6370.
Publication Stats
2k | Citations | |
636.71 | Total Impact Points | |
Top Journals
VU University Medical Center
- • Department of Clinical Genetics
- • Department of Neurology
- • Department of Clinical Neurophysiology
Amsterdamo, North Holland, Netherlands
Radboud University Nijmegen
- Department of Primary and Community Care
Nymegen, Gelderland, Netherlands -
Diakonessenhuis Utrecht
Utrecht, Utrecht, Netherlands
Erasmus MC
- Department of Neurology
Rotterdam, South Holland, Netherlands -
VU University Amsterdam
- Department of Neurology
Amsterdamo, North Holland, Netherlands
University College London
- Department of Neurodegenerative Disease
London, ENG, United Kingdom
Erasmus Universiteit Rotterdam
- Department of Neurology
Rotterdam, South Holland, Netherlands
Brighton and Sussex Medical School
Brighton, England, United Kingdom
Radboud University Medical Centre (Radboudumc)
- Department of Neurology
Nymegen, Gelderland, Netherlands


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By PR Newswire | Article Rating: |
December 10, 2012 05:01 AM EST | Reads: |
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TEL AVIV, Israel, December 10, 2012 /PRNewswire/ --
ISPRA (Israel Public Relations Association) announces that Michael Pranikoff, Global Director of Emerging Media at PR Newswire, will be the guest of honour and key note speaker at its forthcoming conference "Will Content Marketing be the next growth area for Public Relations agencies."
Pranikoff is a vastly experienced, respected and much followed media commentator and educator, and has been spotting trends, shaping events and guiding people through the ever changing media landscape for over 20 years. He has recently been recognised by Cloud Spark as one of the top 52 PR professionals shaping the conversation on Twitter. http://www.cloudspark.com/2012/07/30/top-pr-pros-on-twitter.
His presentation will discuss Search, Social & Syndication - The Key Elements to Successful Content Marketing for PR Agencies. Pranikoff commented: "Over the last two years, marketing & public relations executives all over the world have been flirting with ideas around content marketing. As we see the convergences of Paid, Earned & Owned media, the power of content created by brands is more and more reaching its audience directly." He continued: "Marketing and communications professionals have found that mixing the elements of Search, Social, and Syndication with their content is creating a more cohesive and connected way to tell their stories to their audiences; I look forward to sharing my experiences with the audience in Tel Aviv."
The conference will be held at Tel Aviv University Hall on Wednesday December 12th and will look at the latest trends and best practices as well as discussing the regulatory and ethical principles affecting content creation and distribution.
Pupi Arieli, Chairwoman of ISPRA, commented: "Ongoing changes in communication practice has seen a dramatic increase in the use of content marketing by commercial brands, government agencies and NGOs both globally and locally here in Israel. In many cases content marketing is ahead of regulation and legislation, with extensive use by broadcast and media owners both traditional and online." She continued: "This anomaly raises complex questions such as 'How to and if to regulate', 'Who develops marketing content - advertising agencies, public relations agencies?' and 'Why do we need marketing content at all?' We will address all of these fundamental questions and are honoured to have one of the most influential of today's commentators on the subject in Michael to kick off the debate."
About ISPRA
Israeli Association of Public Relations and Media (http://www.ispra.org.il), is the union of the public relations industry and speaking, Israel, under which about 400 members of this profession private offices, speakers and public relations in business and public service offices.
The goals of the Association are to work on the existence of professional ethics at a high level and public service properly by engaging in propaganda and public relations, increase, improve and promote the level of professionalism of its members through courses, training courses, seminars, symposia, tours and meetings with professional content, and the existence of social and cultural activities among the members.
About PR Newswire
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Published December 10, 2012 Reads 647
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There is no doubt that Big Data is here and getting bigger every day. Building a Big Data infrastructure today is no easy task. There are an enormous number of choices for database engines and technologies. To make things even more challenging, requirements are getting more sophisticated, and the standard paradigm of supporting historical analytics queries is often just one facet of what is needed. As Big Data growth continues, organizations are demanding real-time access to data, allowing immediate and actionable interpretation of events as they happen. Another aspect concerns how to deliver ... Feb. 1, 2015 03:00 AM EST Reads: 3,547 |
By Liz McMillan Scott Jenson leads a project called The Physical Web within the Chrome team at Google. Project members are working to take the scalability and openness of the web and use it to talk to the exponentially exploding range of smart devices. Nearly every company today working on the IoT comes up with the same basic solution: use my server and you'll be fine. But if we really believe there will be trillions of these devices, that just can't scale. We need a system that is open a scalable and by using the URL as a basic building block, we open this up and get the same resilience that the web enjoys. Feb. 1, 2015 02:00 AM EST Reads: 3,171 |
By Liz McMillan The Internet of Things will greatly expand the opportunities for data collection and new business models driven off of that data. In her session at @ThingsExpo, Esmeralda Swartz, CMO of MetraTech, discussed how for this to be effective you not only need to have infrastructure and operational models capable of utilizing this new phenomenon, but increasingly service providers will need to convince a skeptical public to participate.
Get ready to show them the money! Jan. 31, 2015 11:30 PM EST Reads: 3,114 |
By Elizabeth White The Industrial Internet revolution is now underway, enabled by connected machines and billions of devices that communicate and collaborate.
The massive amounts of Big Data requiring real-time analysis is flooding legacy IT systems and giving way to cloud environments that can handle the unpredictable workloads.
Yet many barriers remain until we can fully realize the opportunities and benefits from the convergence of machines and devices with Big Data and the cloud, including interoperability, data security and privacy. Jan. 31, 2015 11:00 PM EST Reads: 2,983 |
By Carmen Gonzalez The 3rd International Internet of @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that its Call for Papers is now open.
The Internet of Things (IoT) is the biggest idea since the creation of the Worldwide Web more than 20 years ago. Jan. 31, 2015 07:30 PM EST Reads: 3,244 |
By Carmen Gonzalez Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world.
Jan. 31, 2015 03:00 PM EST Reads: 3,640 |
By Elizabeth White "People are a lot more knowledgeable about APIs now. There are two types of people who work with APIs - IT people who want to use APIs for something internal and the product managers who want to do something outside APIs for people to connect to them," explained Roberto Medrano, Executive Vice President at SOA Software, in this SYS-CON.tv interview at Cloud Expo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Jan. 31, 2015 02:30 PM EST Reads: 2,775 |
By Elizabeth White SYS-CON Media announced that Splunk, a provider of the leading software platform for real-time Operational Intelligence, has launched an ad campaign on Big Data Journal. Splunk software and cloud services enable organizations to search, monitor, analyze and visualize machine-generated big data coming from websites, applications, servers, networks, sensors and mobile devices.
The ads focus on delivering ROI - how improved uptime delivered $6M in annual ROI, improving customer operations by mining large volumes of unstructured data, and how data tracking delivers uptime when it matters most. Jan. 31, 2015 02:00 PM EST Reads: 3,920 |
By Carmen Gonzalez DevOps Summit 2015 New York, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that it is now accepting Keynote Proposals.
The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long development cycles that produce software that is obsolete at launch. DevOps may be disruptive, but it is essential. Jan. 31, 2015 01:15 PM EST Reads: 2,741 |
By Carmen Gonzalez Wearable devices have come of age. The primary applications of wearables so far have been "the Quantified Self" or the tracking of one's fitness and health status. We propose the evolution of wearables into social and emotional communication devices. Our BE(tm) sensor uses light to visualize the skin conductance response. Our sensors are very inexpensive and can be massively distributed to audiences or groups of any size, in order to gauge reactions to performances, video, or any kind of presentation.
In her session at @ThingsExpo, Jocelyn Scheirer, CEO & Founder of Bionolux, will discuss ho... Jan. 31, 2015 01:00 PM EST Reads: 2,074 |
By Elizabeth White "With easy-to-use SDKs for Atmel's platforms, IoT developers can now reap the benefits of realtime communication, and bypass the security pitfalls and configuration complexities that put IoT deployments at risk," said Todd Greene, founder & CEO of PubNub.
PubNub will team with Atmel at CES 2015 to launch full SDK support for Atmel's MCU, MPU, and Wireless SoC platforms. Atmel developers now have access to PubNub's secure Publish/Subscribe messaging with guaranteed ¼ second latencies across PubNub's 14 global points-of-presence. PubNub delivers secure communication through firewalls, proxy ser... Jan. 31, 2015 12:45 PM EST Reads: 1,817 |
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By Liz McMillan The 3rd International Internet of @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that its Call for Papers is now open.
The Internet of Things (IoT) is the biggest idea since the creation of the Worldwide Web more than 20 years ago. Jan. 31, 2015 12:00 PM EST Reads: 8,190 |
By Elizabeth White Connected devices and the Internet of Things are getting significant momentum in 2014.
In his session at Internet of @ThingsExpo, Jim Hunter, Chief Scientist & Technology Evangelist at Greenwave Systems, examined three key elements that together will drive mass adoption of the IoT before the end of 2015. The first element is the recent advent of robust open source protocols (like AllJoyn and WebRTC) that facilitate M2M communication. The second is broad availability of flexible, cost-effective storage designed to handle the massive surge in back-end data in a world where timely analytics is e... Jan. 31, 2015 12:00 PM EST Reads: 2,859 |
By Elizabeth White "There is a natural synchronization between the business models, the IoT is there to support ," explained Brendan O'Brien, Co-founder and Chief Architect of Aria Systems, in this SYS-CON.tv interview at the 15th International Cloud Expo®, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Jan. 31, 2015 11:45 AM EST Reads: 3,721 |
By Liz McMillan The Internet of Things will put IT to its ultimate test by creating infinite new opportunities to digitize products and services, generate and analyze new data to improve customer satisfaction, and discover new ways to gain a competitive advantage across nearly every industry. In order to help corporate business units to capitalize on the rapidly evolving IoT opportunities, IT must stand up to a new set of challenges.
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By Elizabeth White The BPM world is going through some evolution or changes where traditional business process management solutions really have nowhere to go in terms of development of the road map. In this demo at 15th Cloud Expo, Kyle Hansen, Director of Professional Services at AgilePoint, shows AgilePoint's unique approach to dealing with this market circumstance by developing a rapid application composition or development framework. Jan. 31, 2015 11:30 AM EST Reads: 2,419 |
By Yeshim Deniz ARMONK, N.Y., Nov. 20, 2014 /PRNewswire/ -- IBM (NYSE: IBM) today announced that it is bringing a greater level of control, security and flexibility to cloud-based application development and delivery with a single-tenant version of Bluemix, IBM's platform-as-a-service. The new platform enables developers to build ap... Jan. 31, 2015 11:15 AM EST Reads: 3,366 |
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By Pat Romanski An entirely new security model is needed for the Internet of Things, or is it? Can we save some old and tested controls for this new and different environment? In his session at @ThingsExpo, New York's at the Javits Center, Davi Ottenheimer, EMC Senior Director of Trust, reviewed hands-on lessons with IoT devices and reveal a new risk balance you might not expect. Davi Ottenheimer, EMC Senior Director of Trust, has more than nineteen years' experience managing global security operations and assessments, including a decade of leading incident response and digital forensics. He is co-author of t... Jan. 31, 2015 11:00 AM EST Reads: 3,467 |


text:
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earse contents of file with php
Another PHP question
PHP question
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anyone know of a good php calendar app?
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text:
Op-Ed: Mayor should resist cop pension rollback
The old provisions don't distinguish between those actually injured on the job and those with conditions presumed to be job-related.
The old provisions don't distinguish between those actually injured on the job and those with conditions presumed to be job-related.
Christina Schwarz, 35, was promoted to Partner. She previously held the position of Associate.
We will retrieve important information on individual stocks and mutual funds, including analysts' reports and opinions, and demonstrate the advanced search capabilities of each database. Join us...
Catherine Nolan, a Queens Democrat, announced her bid to replace Sheldon Silver as speaker of the Assembly. Soon after, Assemblyman Carl Heastie of the Bronx did the same. Brooklyn's Joseph Lentol also said he would run.
The founder of such restaurants as Union Square Cafe and Eleven Madison Park is about to get rich from burgers and fries.
Embattled Assembly Speaker Sheldon Silver is taking a leave of absence from Weitz & Luxenberg, the law firm at the center of corruption charges against him.
Los Angeles-based Estate Four plans to build a $400 million project that includes offices, shops, performance spaces and a promenade in the industrial Brooklyn neighborhood.
As it was in the 2013 contest for City Council speaker, institutional reform is a key demand from many members whose votes are being courted.
Also: Could one of the Assembly's women win?
If things are really so bad, how come firms that manage trillions' worth of investor money aren't talking about getting fleeced?
Failed to access your request. Try Again?


text:
People News
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Show Updates
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The Bachelor
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The Bachelor
The Bachelor 11
'Bachelor' creator on Brad Womack rejections: He sort of said, 'F**k it.'
By Christopher Rocchio, 11/21/2007
Brad Womack
gave his own reasons for
both of his two remaining suitors during
The Bachelor
eleventh-season final Rose Ceremony, however show creator Mike Fleiss apparently has his own thoughts on why
Jenni Croft
DeAnna Pappas
each went home empty-handed.
"He just sort of woke up that day, was cranky, and sort of said, 'F**k it,'" Fleiss
Entertainment Weekly
during a Tuesday interview. "He couldn't see himself with either of those chicks and so he blew them both off."
Despite the fact that Womack and Fleiss had rooms right next to each other during filming for
The Bachelor
over the summer, Fleiss said he "didn't see" Womack's decision coming until he revealed it to producers on the day the final Rose Ceremony took place.
RealityTVWorld: The Bachelor
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"Much like Jenni and DeAnna, I was convinced this guy had fallen for one or both of these girls," Fleiss told
Entertainment Weekly
. "It was a shock to the whole staff. When we knew how he wanted to play it, it was like a morgue around here. Usually at the finale there's a happy couple afterwards and they're all drinking champagne. This time when it happened the staff just freaked out. Everyone shlumped back to their cars. It was really dark."
Fleiss added he's still unsure why Womack gave Croft and Pappas the understanding that one of them would receive his final rose and even shopped for a diamond engagement ring.
"I don't know why he said the things he did. I don't know why he let the girls say the things they did. I don't know," Fleiss told
Entertainment Weekly
. "Maybe he was trying up until the last minute to make it work. Only Brad knows for sure."
While he's uncertain what was going through Womack's mind, Fleiss said he's aware that
The Bachelor
ending was "going to be controversial and that some viewers would say, 'F**k that. I'm never watching the show again.'"
Fleiss said a marriage proposal from a
The Bachelor
star to one of his suitors is "not mandatory" -- something that's evident from the fact that four of the last five and six of the last eight
The Bachelor
editions ended without its star proposing to his final bachelorette. Still, Womack was the first
The Bachelor
star ever to not even offer a final rose to one of his suitors in an attempt to pursue a relationship in the real world.
"It's not supposed to be a guaranteed proposal," Fleiss told
Entertainment Weekly
. "It's about how men and women relate and date. It's about getting into the mind of a single guy and the mind of a single girl, and we certainly got that. What [Womack] did was the thing that women fear the most -- he became intimate and then split the next day. The fact that it happened to two girls at once was a unique opportunity."
However it was apparently a "unique opportunity" that ABC wasn't too thrilled with.
"They weren't happy about it," Fleiss told
Entertainment Weekly
. "They would much prefer a proposal and a happy couple like [
The Bachelor
first-season lovebirds
Trista Rehn
and Ryan Sutter, who have since
had a child
] or [
The Bachelor
sixth-season couple
Byron Velvick
Mary Delgado
, who are engaged but have yet to wed]."
ABC also apparently wasn't too be pleased with the original ending Fleiss came up with even after Womack rejected both Croft and Pappas.
"The original ending -- before the network made me change it -- was after the girls were crying we fade down and come back up to a shot of Brad sitting on the couch, remote control in hand, clicking on the game, munching on a submarine sandwich," he told
Entertainment Weekly
. "That's what I wanted at the end. But the network said no."
While Fleiss gushed about Womack doing a "great job" and being a "great guy," he also expressed some regrets about the most recent
"I wish he would have been a little more committed to making those girls happy too. I think that's what was lost," he explained to
Entertainment Weekly
. "Those girls really put themselves out there. Jenni might have been more open with her emotions than any other girl in the history of the show. She wasn't a blithering, crazy girl. You felt like she was truly in love. I really felt for her. I felt myself tearing up, which almost never happens."
Fleiss told
Entertainment Weekly
that in addition to airing a twelfth
The Bachelor
installment next spring, ABC is also planning to air a new season of
The Bachelor
-- the last edition of which aired in Spring 2005 -- next summer. ABC couldn't confirm Fleiss'
The Bachelor
comment when reached by Reality TV World on Wednesday.
According to Fleiss, it's still unknown who would star in
The Bachelor
Summer 2008 fourth edition.
(Photo credit ABC)
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Former 'The Bachelor' bachelorette Jenni Croft expecting first child
Report: 'The Bachelor' star Brad Womack back with his ex-girlfriend
'The Bachelor' star Brad Womack contradicts himself in new interview
Ellen DeGeneres apologizes for calling 'Bachelor' Brad Womack a jerk
'Bachelor' suitor Jenni Croft reunited with ex immediately after filming
'The Biggest Loser' crowns Toma Dobrosavljevic Season 16 champion, runner-up Sonya Jones loses by one pound
'The Bachelor' bachelorette Juelia Kinney: Chris Soules would be lucky to have Britt Nilsson
Bruce Jenner reportedly filming his own E! reality show documenting his "journey"
'The Bachelor' host Chris Harrison: Kelsey Poe is kind of a spoiled brat, Ashley Iaconetti is immature and obsessed with herself
Bruce Jenner steps out with fuller-looking lips
'The Bachelor' star Chris Soules: I think my Final 3 bachelorettes will surprise everyone
Farrah Abraham may still want to get her butt done despite recent botched lip injection procedure
Kim Kardashian on Kanye West relationship: It's so normal, he even makes me lunches
Bettina Bell
Brad Womack
Chris Harrison
DeAnna Pappas
Erin Gardner
Hillary Reisinger
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Jessica Kiss
Kim Hessel
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Lil Wayne sues Cash Money for $51 million over breach of contract
Justin Bieber apologizes for his "arrogant" behavior
Taran Killam, Cobie Smulders welcome second child
Taylor Swift "died" after learning Madonna likes her music
Katie Cassidy "thrilled" to portray Black Canary on 'Arrow'
Kate Hudson stuns in cutout dress at Versace show
Zachary Quinto won't appear on 'Heroes Reborn'
Taylor Swift shares bikini photos of Hawaii vacation with Haim
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text:
Maruoka, Akira
2011, XVII, 281 p.
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Computation lies at the heart of modern digital technology and our increasingly advanced information society. The theory of computation describes what tasks can and cannot be computed, and how efficiently the computable tasks can be computed.
This focused and accessible guide/textbook presents a thorough foundation to the theory of computation, whilst also providing a deeper insight for those looking to pursue research in this field. Combining intuitive descriptions and illustrations with rigorous arguments and detailed proofs for key topics, the logically structured discussion guides the reader through the core concepts of automata and languages, computability, and complexity of computation. Self-contained and supported by practical examples, the text is suitable for a one- or two-semester undergraduate course in the theory of computation.
Topics and features:
This hands-on and easy-to-read textbook/reference is ideal for undergraduate students of computer science and related disciplines needing to develop a deep understanding of this fascinating field, even if they have no prior knowledge of the subject.
Dr. Akira Maruoka is a professor in the Faculty of Science and Engineering at Ishinomaki Senshu University, Japan.
Content Level » Lower undergraduate
Related subjects » Computational Science & Engineering - Theoretical Computer Science
Get alerted on new Springer publications in the subject area of Theory of Computation.


text:
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text:
This location is shown only to members
'Finger in the Pie Cabaret' - show and dinner - tickets are available from £12.25, however, the show and a meal is only £27.00 with reserved seating. I have contacted the venue and been told if members book their tickets in advance we can request a table together which would be nice. Tickets can be booked at www.lastminute.com - please note I am a veggie and I had to telephone last minute directly to have this option available. Once you have booked a ticket send me your name and order number and I will contact the venue regarding seating arrangements. The show is listed as the following:
'Finger in the Pie's burlesque bonanza is a packed night of cabaret, comedy, burlesque and variety - saucy side shows and vulgar vaudeville. Acid tongued queen of cabaret Myra Dubois presents a jam packed line-up of cabaret including the musical musings of Rayguns Look Real Enough, breathtaking contortionists Jen and Jess as well as burlesque from Shirely Windmill, Bandage Burlesque and Chastity Yields.
Finger in the Pie Cabaret is London's largest showcase of new Variety, Vaudeville and Burlesque based in Madame JoJos - London's most famous Cabaret Venue, an intimate West End nightclub still going strong after 50 years.' More information can be found on Lastminute's website.
Hi, I'm here now, there is a queue and I will be inside the venue, see you soon, Tina
February 3, 2013
Hi as a new member would appreciate someone meeting me, thanks and I look forward to meeting you all.
January 26, 2013
hi i will be coming up from Kent , to my mother who lives in SE LONDON i think it will be easier for me to come into London by BR at Charing cross can you let me know what time you are meeting up and when will the cabaret be finishing , as i will have to go back to my mothers to collect my car and drive back to Kent, I am registered disabled but have found it very difficult to find disabled parking in London. I would be appreciative if some one could let me know where the met up point will be as i will be on my own thanks and looking forward to meeting you all . bye for now
January 3, 2013
I started the group because there wasn't any other type of group like this. I've met some great folks in the group who have become close friends and have also met some amazing business owners.
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Jamaican born songstress, Tanice Morrison was involved in music as early as age 6.
With a blend of R&B, Jazz and Soul, she manages to fuse these elements with her own distinctive style of Reggae Roots.
Creating a unique sound that would set her apart from her musical peers. By the time she was 12, Tanice knew signing was her destiny, and was quite determined to get her break in the music industry. She began taking the music business quite seriously and would write and perform her own lyrics wherever she went.
The former school teacher admits that singing and performing is her true
passion. She states that "Music is my place of solace and will always
use it to uplift the lives of others." In November 2004, she was part of
an opening act for legendary country singing sensation, Kenny Rogers,
along side Earnest (Ernie) Smith and Maxi Priest. She has also been on
billings with the Marley brothers, Rita Marley, Marcia Griffiths,
Capelton, Ken Boothe and others the Studio One 50th Anniversary, in the
same year.
Her performance at the Powerful Women and Men in
Concert on November 7, 2010, showed off her versatility and creativity
as an artiste on the local scene.
With her inspiration coming
from legendary music icons such as Marcia Griffiths, Gladys Knight, Mary
J. Blige, Anita Baker, Whiteney Houston, Celine Dion and Stevie Wonder.
She believes though, that her mother is her greatest inspiration. This
female artiste has managed to maintain her musical sense of style and
continues to make great and impactful music.
Do you have a great story about him/her? Share it!
Click below to see contributions from other visitors to this page about this artiste...
Singer/Songwriter Tanice Morrison new single 'Rather Be Me' Not rated yet
I am Singer/Songwriter Tanice Morrison from Kingston, Jamaica currently promoting a new original release "RATHER BE ME".
Please visit my website www.tanicemorrison …
Return home from Tanice Morrison page
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Ex-ECB chief Trichet is new chairman of G30
FRANKFURT (Reuters) - Former European Central Bank president Jean-Claude Trichet is to become the new chairman of the Group of Thirty (G30), an international forum of public and private sector financial leaders, the group said on Tuesday.
Trichet, who was ECB president until his eight-year term expired at the end of last month, succeeds Jacob Frenkel, chairman of JP Morgan Chase International.
The G30 says on its website it aims to deepen understanding of international economic and financial issues, to explore the international repercussions of decisions taken in the public and private sectors, and to examine the choices available to market practitioners and policymakers.
Trichet said in a statement: "This is a time of exceptional challenges to the global economic and financial system, and the G30 will continue to make significant contributions to the policy debate and enhance understanding of the critical paths to stability and to economic growth."
The G30, which used to be known as The Consultative Group on International Economic and Monetary Affairs, is a private, non-profit organisation.
(Writing by Paul Carrel; editing by Anna Willard)
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After wave of QE, onus shifts to leaders to boost economy
DAVOS, Switzerland - Central banks have done their best to rescue the world economy by printing money and politicians must now act fast to enact structural reforms and pro-investment policies to boost growth, central bankers said on Saturday.
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Louis van Gaal's side recorded their six Premier League win on the trot by easily dispatching of the under-performing visitors, with David De Gea in inspired form while
Manchester United secured a sixth consecutive Premier League victory by beating bitter rivals Liverpool 3-0 at Old Trafford.Wayne Rooney netted a ninth goal in his last eight appearances on home turf to give United a 12th-minute lead, 25 seconds after Raheem Sterling passed up a fine opportunity to put Liverpool ahead.
Louis van Gaal's men doubled their advantage in controversial circumstances after 40 minutes as Juan Mata stooped to score from Robin van Persie's flick - replays clearly showing the Spaniard to be offside.
Liverpool created the clearer openings over the course of the contest but poor finishing from Sterling and Mario Balotelli - plus another brilliant display from United goalkeeper David de Gea - served to frustrate them before Van Persie completed the scoring with a little over 20 minutes left.
By Peter O'Rourke Manchester United have made it six Premier League wins in a row, but how much different could it have been but for David de Gea. Much of the talk before the game was about goalkeepers with Simon Mignolet dropped for Brad Jones, but De Gea will dominate the post-match discusssion. The Spaniard was unbeatable between the posts for United, making a hat-trick of saves from Raheem Sterling and two more from a lively Mario Balotelli. United were not at their best but, in truth, never looked like needing to be as they easily took advantage of sloppy defending from the visitors to score through Wayne Rooney, Juan Mata and Robin van Persie. |
Brad Jones played a first Premier League game in almost two years Liverpool as under-fire number one Simon Mignolet dropped to the bench, where Balotelli was named having overcome a groin injury.
The intrigue in the United line-up came at the other end of the pitch as youngster James Wilson was selected to partner Van Persie up front, with Rooney playing a supporting role in an attacking line-up.
Marouane Fellaini collected a worryingly early booking for clattering through Adam Lallana but the England international recovered to thread a deft through ball for Sterling to draw a first save of the match from De Gea in the 12th minute.
United surged back at Liverpool immediately to open the scoring - Antonio Valencia nutmegging Joe Allen and picking out Rooney, who was afforded ample room to steer home side-footed from 16 yards.
De Gea held a deflected drive from Steven Gerrard as Liverpool looked to regain their footing and Sterling gave the Spain goalkeeper a more taxing save when he skipped past Phil Jones in the 23rd minute.
The visitors were then forced into a defensive change, Glen Johnson hobbling off to be replaced by Kolo Toure, and they fell 2-0 behind five minutes before the interval.
Ashley Young cut back to cross right-footed and Van Persie glanced on for Mata to nod home from an offside position, but the goal stood.
Balotelli came on for Lallana at the break and Jordan Henderson headed Sterling's left-wing centre wastefully over as Liverpool sought a quick response.
Sterling then spurned his team's clearest opportunity of the match, allowing De Gea to block after Jonny Evans' wretched backpass sold his goalkeeper short.
Van Persie should have put the result beyond doubt after the hour when he side-footed wide from Valencia's excellent low delivery, and De Gea's finest moment arrived midway through the second period as he touched Balotelli's snapshot onto the crossbar with a stunning reaction save.
And with 18 minutes remaining, Van Persie atoned for his earlier miss as Mata gave him a simple finish after Dejan Lovren woefully misjudged a clearance.
Balotelli was twice frustrated by De Gea from close range once more before Jones produced a save to compare with his opposite number's collection in the 87th minute, as Van Persie smashed towards the roof of the net.
Challenging for a top-four place to return to European football's top table next season looks an increasingly tall order for Liverpool, who lie ninth - 10 points behind United in third.


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"It's all about me and my friends in Las Vegas just trying to achieve our goals with all the drama and craziness which goes along with it," the Sun quoted her as saying.
Holly Madison coming up with own reality show
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FRONTLINE reveals the hidden story of the NFL and brain injuries.
FRONTLINE investigates the accusations of criminality and corruption that have surrounded Vladimir Putin's reign in Russia.
What are the costs of doing business in a war zone? FRONTLINE and ProPublica investigate the relationship between Firestone and the infamous Liberian warlord Charles Taylor.
FRONTLINE follows renowned writer and surgeon Atul Gawande as he explores the relationships doctors have with patients who are nearing the end of life.
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Each year, six thousand Americans lose their lives on the job. Tens of thousands more are seriously injured or exposed to deadly poisons and carcinogens in the workplace. Yet if one of those workers dies on the job due to a company's willful disregard for federal safety regulations, the maximum penalty his employer faces is just six months in prison. Are America's workplace safety laws tough enough? And are companies being held responsible for protecting the safety of their employees? FRONTLINE investigates workplace safety in one of America's most dangerous industries.
published jan. 9, 2003
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New York State Attorney General Eric T. Schneiderman, local officials, doctors and pharmacists today hailed a new program the state approved to track prescription drugs as a model they hope other states and the nation will adopt, while some also called for additional measures.
Schneiderman, who proposed the legislation last June, spoke at a press conference at the Mineola offices of the Long Island Council on Alcoholism and Drug Dependence.
The legislation, known as the Internet System for Tracking Over-Prescribing Act or I-STOP, creates an online prescription database designed to help health care providers track and curb excessive use, and reclassifies certain drugs so they won't be as easy to obtain in large quantities.
[dmc-related-post-wp numitems="3" title="Also read"]The issue of prescription drug abuse came to the forefront on Long Island and statewide, after the murder of four people in a June 19 shooting when David Laffer and Melinda Brady robbed Haven Drugs pharmacy, taking thousands of painkillers.
The deaths led to arrests and prosecution not only of Laffer and Brady, but of doctors who provided them and others with large quantities of medications.
"With I-STOP, we are creating a national model for smart, coordinated communication between health care providers and pharmacists to better serve patients, stop prescription drug trafficking and provide treatment to those who need help," Schneiderman said.
I-STOP will make New York the first state to mandate that physicians consult a database for a patient's prescription history, before prescribing a wide range of medications and will require real-time reporting when these prescriptions are filled.
The legislation also changes classification of certain medications and ends automatic refills for hydrocodone.
It mandates electronic prescriptions for certain medications and creates a program for disposing of expired and unneeded drugs, so they aren't left in medicine cabinets where children and addicts might find them.
"Doctors and pharmacists will be better equipped to sort out the doctor shoppers and pharmacy hoppers, while at the same time ensuring that those with legitimate needs have appropriate access to life-enhancing medications," Dr. Jeffrey Reynolds, executive Director of Long Island Council on Alcoholism and Drug Dependence, said. "With concrete facts in hand, prescribers and dispensers can begin to say 'no' to those who are misusing and diverting prescription medications."
Long Island officials said the legislation will be a powerful tool in tracking prescriptions, by giving providers immediate access to information.
"The new registry will help save lives by preventing overprescribing of medications, reducing the flow of pharmaceuticals to drug traffickers and assisting in the identification and treatment of patients who are at risk of addiction," Nassau County Executive Ed Mangano said. "This is a giant leap forward, yet there is more to do in this war on prescription drug abuse."
Prescription medication use has become a national, statewide and Long Island problem, leading to deaths and a black market medication market. Statewide prescriptions for hydrocodone have increased 16.7 percent, while those for oxycodone increased 82 percent, between 2007 and 2009, according to the Attorney General's office.
Long Island, in particular, has become a hotbed of prescription drug use and abuse. Oxycodone prescriptions in Nassau increased by 42 percent and in Suffolk by 23 percent from 2008 to 2010.
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