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Harrisburg WordPress User Group Message Board › Meetup Topic Suggestions
Ryan D. |
Lets open a topic for ideas... what do you want to hear about? What are your WordPress problems? Please dish... it'll help me figure out what the groups needs are and topics to present on.
Here's a running list I have going of things that haven't been covered yet or have been requested:
Edited by Ryan Duff on Apr 21, 2014 10:12 AM |
Jonathan |
Ok, I'm using WooCommerce to add eCommerce functionality for a client, but that's just the beginning. WooCommerce does a lot, yet you may find some small things that it doesn't do out of the box, but your client needs. As an example, my client needs to charge a flat shipping rate on some of their products. WC offers flat rate, but not per item. So to solve this I added yet another plugin that offers the ability to add the shipping rate on an item-by-item basis.
I'd like to hear about other people's solutions to problems like this that have come up. It's easy for me to say, well, there's a plugin for that. But until I get the plugin installed and working on the project I'm not aware of some drawbacks. Another plugin that I'm using for the same client is Events Manager Pro because my client wants to offer ticket sales on their website and move away from EvenBrite and the fees involved. I've looked at a lot of EventBrite alternatives and all seem to have their pros and cons and collect fees one way or another. Events Manager Pro os in no means a perfect replacement for the functionality of Event Brite, but it seems to offer enough of a solution for the client. I'd also be interested in hearing about workflows for WP development. Let's say you already launched a website on WP and the client wants to add new features. You can download the BackupBuddy file, install it locally to you dev work. How do you go about showing the client the new features that are running locally? And how do you integrate content that may have been added to the production website by the client to your local version before you do a new production launch? That's just some stuff I'm thinking about off the top of my head. |
Matthew H. |
Regarding Ryan's email about beginner topics... here's a few:
Integration of 3rd party tools that someone launching a new business would need. Such as
From a beginner's point of view, Wordpress' features appear to be limited to what you get out of the box: posts, pages, categories, and not much more. Think of this topic from an entrepreneurial point of view. Think about the business owner that's launching a new business and the 3rd party tools that are critical to have in place. Business owners often think it's difficult to find/configure the right plug-ins/widgets. Show them how easy it can be. Also... think of SquareSpace and what they offer. Although I don't use SquareSpace, or know anyone who does, they seem to be selling the service as something that has a spectacular photo gallery, that has a great merchant package, that can easily integrate with external services like facebook, flickr, etc. In other words, to the entrepreneur, it seems like having these things on Wordpress requires too much research/time/skill. Whatever you can do to shed some light on how easy it is to extend Wordpress so it includes these critical business features would appeal to the first time user. The subject for the meetup could be: "Wordpress features every new business should have." Hope this helps! |
Julie P. |
Hello, I am a beginner. I think the above suggestions are really great. Here are a few other ideas:
Customizing your Wordpress site and making it your own. Little tweaks that can add a big punch. Development Phases- break a Wordpress project into phases so you can literally work through a whole project. Integrations- What Wordpress plays wells with. |
Travis T. |
I'd be very interested in learning about version control for easy development!
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Tap Here to view the Mobile Optimized TFLN
This really high kid past out in the corner of the room holding a box of cheez its in his arm. My idol.
To this day, I regret not having sex in the bathroom
Omg I literally just wanna sleep with you right now. Like actual sleep. Not sex. Well maybe. But sleep first
I went to the strip club tonight. I had never gone, and in a panic I gave the dancer giving me a lap dance a handshake and introduced myself. Redefines business casual.
It's 4:30 AM and I just walked through a line of 10 deer without them freaking out. I am the campus deer king.
I just added Tubthumping to the playlist for tonight. This is going to make or break the party.
She knew the head wasn't all that so she gave me her taco. I'm will in to give her a second chance.
he just fluffed my hair and told me I had to dance with him because we were both gingers.
Fly, little bird! Repopulate the ginger race!
Taylor Swift needs more songs about threesomes. I'm not sure she gets me anymore.
Also if i get drunk and start crying about the elephants you all have my permission to abandon me.
Nothing kills the mood like him going to slap my ass and he hits his balls at the same time
Easy Mac and you are the sexiest things in my life
Yeah then you killed that bottle of Bacardi in under 20 minutes. So much for being an organ donor.
I'm sending midget strippers dressed as bull fighters with mini bottles of 1800 to your house. Already made the call. Jer is going halves on it. Can't be stopped! Won't be stopped!
Plus i lost a button on my shirt and we got free drinks all night. Sorry I'm not sorry.
Follow @tfln

subset: commoncrawl


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No angel but not guilty, says banned Chelsea striker Costa
LONDON - Chelsea striker Diego Costa has denied he deliberately stamped on Liverpool's Emre Can but admitted to being no angel on the field.
Recent Sports News
Chelsea stay five clear after 1-1 draw with Man City
LONDON - Chelsea and Manchester City drew 1-1 in their top-of-the-table Premier League clash at Stamford Bridge on Saturday, leaving Jose Mourinho's team five points clear of City but with the champions still believing they can retain their title.
Rodgers welcomes back Sturridge's goalscoring touch
LONDON - Liverpool manager Brendan Rodgers welcomed back the return of Daniel Sturridge's goalscoring touch on Saturday with the admission that the Reds have missed their England striker.
France keeper Lloris tips Kane to play for England
LONDON - Players past and present urged England manager Roy Hodgson to call up Harry Kane for his next squad after the striker took his season's tally to 20 goals with the double for Tottenham Hotspur which sank West Bromwich Albion on Saturday.
Hull players must fight harder to avoid crisis - Bruce
LONDON - Hull City manager Steve Bruce warned his players that they must fight harder if they are to avoid a Premier League relegation scrap after they slumped to a 3-0 home defeat by Newcastle United on Saturday.
Levins registers shock double at NY Armory
NEW YORK - Canadian Cam Levins claimed a startling double by winning the mile then upsetting celebrated training mate Galen Rupp half an hour later in the two-mile race at the Armory Track Invitational on Saturday.


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obiee jobs near Ridgefield, CT
OBIEE Developer
- Stamford, CTimplement OBIEE dashboards and reports • Must have the ability to implementing OBIEE ... in OBIEE merge functionality is a considered a plus • Experience in OBIEE systems...
29 days ago from Oracle -
Oracle BI Architect
- Stamford, CTKnowledge of related solutions such as OBIEE, Oracle Data Integrator, Endeca, Essbase, and Golden Gate is desired. **Job:** **Consulting** **Organization:** **Oracle** **Title:**...
1 day ago from Oracle -
Consulting Project Director
- Stamford, CTReSA, RTM, RIB, IGS, OBIEE, IDM, OAM, ADF, Retek, Retail; Planning, supply chain, optimization, forecast, program management, project management, program director **Job:**...
18 days ago from Oracle -
Principal Sales Consultant -Healthcare Provider and Healthcare Payor
- Stamford, CTtools, reports and dashboard creation (e.g., OBIEE Answers, Security, RPD) * Big Data solutions and their application to the Healthcare Industry **Job:** **Pre Sales**...
30+ days ago from Oracle -
BI Developer, Real Estate Technologies
- Stamford, CTto design and develop complex interactive OBIEE reports, including prompts, filters, ... OBIEE and ETL, possibly maintaining existing OBIEE infrastructure and modifying as needed...
30+ days ago from Oracle -
Business Analyst 4-Ops
- Stamford, CTsql/plsql, Application Express, and / or OBIEE experience a plus * Scrum Master certification (CSM) a plus **Job:** *Business Operations* **Organization:** *Oracle* **Title:**...
30+ days ago from Oracle -
Informatica Engineer
- Stamford, CTOBIEE experience preferred. • Background knowledge of Oracle HRMS, iRecruitment, Taleo, Fusion HCM is an advantage. Skills / Other Personal Attributes Required: • Must have good...
29 days ago from Oracle -
BI Snr Manager
- Stamford, CTand OBIEE pre-build data models Preferred Qualifications: Management of global ... with HR OBIEE and/or Oracle HRMS, iRecruitment Taleo, Fusion HCM **Job:**...
29 days ago from Oracle -
Senior Principal Consultant
- Stamford, CTUtilities Analytics (OUA) / OBIU / OUBI OBIEE BI Publisher OWB ODI OBIEE Answers and Dashboards ETL / ELT for Utilities Oracle Utilities Edge applications including CC&B, MDM and...
30+ days ago from Oracle -
Consulting Technical Director
- Stamford, CTWebLogic, Oracle FMW, OBIEE, Utility Application Framework * Multiple product exposure ... middleware, OBIEE, utility application framework, turning, configuration; **Job:**...
30+ days ago from Oracle
Email jobs like this to me


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The announcement that Photos for the Mac will replace iPhoto and Aperture have left many upset and unsure where to go. Many are looking to Lightroom and Adobe is happy to help. Adobe has many plans for Lightroom, but not all will benefit the user.
Adobe has recently moved to a subscription service for almost all of their applications under their Creative Cloud. Lightroom is one application that is available both on the Creative Cloud and standalone. Lightroom for the iOS is only available on the Creative Cloud. The question is not if Adobe will move Lightroom for the Mac to the Cloud only, but when. The cost may be cheaper than the $10 a month it is right now, which is for both Photoshop and Lightroom. Still, most don't want to subscribe to software.
Adobe does not have a monopoly on the photography market like they do on the professional graphic design market. There are a lot of great photography tools out there today. These applications continue to improve at a faster rate than Adobe updates their applications. The longer users can wait, the more options they will have in replacing Aperture.
For users who are still using Aperture as their RAW converter, editor, and photo manager, the best option is to wait. Users should first wait and see what Apple has in store for Photos for the Mac. Other developers are hard at work and waiting to see what they come up with in the next six months may prove beneficial. Developers now know there is a hole opening up and a lot of Aperture users are looking for another tool. Adobe is the first to jump on the bandwagon and offer an easy path, but they won't be the last. Aperture still works, so it is best to keep using it and see what other options become available. Adobe and Lightroom will always be there ready to take your money if one chooses to switch.
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- Apple is racing towards making iPhone the new digital lifestyle hub


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Burn wrote:Please don't clog this thread up with garbage. Either post a real picture of yourself, or tell Va'al how pretty he is.
YoungPrime wrote:Everyone's psyched about this "gimmick" but the thing is that those data disc's look horrible in alt mode.
If I buy it it'll be strictly for Soundwave not those crappy disc.
JelZe GoldRabbit wrote:RAcast wrote:primerez wrote:What is ML Soundwave?? Anyways I will be definitely be nabbing him. I am a big Soundwave fan so this is a win!
Music Label. He's' a working MP3 player, only about 2 gig of storage though, if I recall correctly.
Actually it's just 1 GB, but there are ways you can extend it to 2 GB.
highburn wrote:He's not out of scale if you put G1 Soundwave beside G1 Prime and Megs, Soundwave was a larger toy. See Soundwave superior...smaller toys inferior.
leakin' lubricant wrote:Would have rather seen a Shockwave upscale in all honesty, does anyone konw if this is on the cards, or is that just too much to ask for?
warzon3 wrote:Anyone have any info on how tall FOC Voyagers will be?
Maybe some of you guys have seen him in person on display, how would he stack up against a Classics Prime?
Stumpybot wrote:Soundwave needs to be a voyager to incorporate the play feature, but its fair point about the scale.
Return to Transformers Toys Discussion
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Draft profiles i thought this might be interesting to those of u who will want to see what type of players we might be able to find with our late round picks. [url]http://www.nfl.com/draft/profiles[/url] |
this is one guy gibbs and company have looked at as a good fit for h-back that we might be able to get if a 4th rounder is possible to get in a trade or even with our 5th rounder. [url]http://www.nfl.com/draft/profiles/chris_cooley[/url] |
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Undaunted: Daring to Do What God Calls You to Do - eBook
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Format: DRM Protected ePub Vendor: Zondervan Publication Date: 2012 ISBN: 9780310333883 | ISBN-13: 9780310333883 UPC: 025986333881 Availability: In Stock |
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Undaunted Participant's Guide: Daring to Do What God Calls You to DoChristine CaineZondervan / 2012 / Trade Paperback$7.99 Retail:5 Stars Out Of 5 2 Reviews
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Publisher's Description
Christine Caine offers life-transforming insights about how not only to overcome the challenges, wrong turns, and often painful circumstances we all experience, but also to actually grow from those experiences and be equipped and empowered to help others. Using her own dramatic life story, Caine shows how God rescued her from a life where she was unnamed, unwanted, and unqualified. She tells how she overcame abuse, abandonment, fears, and other challenges to go on a mission of adventure, fueled by faith and filled with love and courage. Her personal stories inspire readers to hear their name called, just as Christine heard her ownYou are beloved. You are the hope. You are chosento go into a dark and troubled world, knowing each of us possess all it takes to bring hope, create change, and live completely for Christ. Part inspirational tale, part manifesto to stir readers to lives of adventure, Your God Is So Big! shows the way with spiritual wisdom and insight. Her mission to fight injustice by focusing on one person at a time will inspire and awe readers to see how we are joined in a unique mission, products of eternity, positioned in time, pressed to make the most of our lives on a quest filled with adventure and drawn by faith.
Product Reviews
cc5 Stars Out Of 5undaunted: daring to do what God calls you to doDecember 19, 2014ccThis review was written for Undaunted: Daring to Do What God Calls You to Do.amazing book - quite challenging and very Bible based!
tam tam5 Stars Out Of 5life changing bookDecember 12, 2014tam tamQuality: 5Value: 5Meets Expectations: 5This review was written for Undaunted: Daring to Do What God Calls You to Do.truly a servant of God who shares her love and passion for doing what God's called her to do. after reading this book if it does'nt motivate you i dont know what will. God speaks right through her. i bought several for Christmas gifts.
Nancy5 Stars Out Of 5Excellent book!October 31, 2014NancyThis review was written for Undaunted: Daring to Do What God Calls You to Do.Best book I have read in a long time! I am purchasing more copies of this book to give away to people. Christine Caine is an outstanding speaker and author. I believe Christine Caine is being used by God at this time in history to bring hope and light to so many hurting people!
mamaroseAge: 45-54Gender: female5 Stars Out Of 5very good bookOctober 25, 2013mamaroseAge: 45-54Gender: femaleQuality: 5Value: 5Meets Expectations: 5This review was written for Undaunted: Daring to Do What God Calls You to Do.this book is a book of true hope for who ever is going through anything in their life!
DavidsMomLouisianaAge: 25-34Gender: female5 Stars Out Of 5Living an UNDAUNTED lifeJuly 15, 2013DavidsMomLouisianaAge: 25-34Gender: femaleQuality: 5Value: 5Meets Expectations: 5This review was written for Undaunted: Daring to Do What God Calls You to Do.UNDAUNTED by Christine Caine
I first found out about Christine Caine by attending a women's conference. I have started one of her other books, but I have found this book was so easy to read! It was easy to find myself constantly turning to pages. It is like sitting and listening to someone interesting tell a story that you want to hear. Most of all, her stories are encouraging. I really enjoyed her chapter on fear. We share a fear of flying, and it was interesting to see her take on it. I was also experience some other momma fears and the scriptures and the way she looked at things, really helped me to have Faith that God is on my side and there to protect me. May we all strive to live an undaunted life doing what God has called us to do!
You also think you have had a crazy life, but Christine has a lot of stories to tell that we can all build upon or see we don't have it that bad. She continues to praise God through it all. I also love her passion for rescuing women. She is such an amazing person with such an inspiring story.
I am very thankful for Zonderan and the booksneeze reading program for this copy of this book.
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"EMC - after 17 years "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I have been working at EMC full-time (more than 10 years)
The Company is very bottom line oriented.
Rewards people with stock and bonus.
Employees expected to work 60 hours/week.
Lots of out sourcing
Do less out sourcing
"A fantastic company focused on its employees "
- Comp & Benefits
- Career Opportunities
I have been working at EMC full-time (more than an year)
ProsAlong with one of the technology industry's best compensation & benefit plans, there are so many ways for EMC Employees to customize their careers & get involved to make a difference. We are able to attract & recruit the best-of-the-best and the synergy created from collaboration results in EMC distancing itself from the competition.
ConsIf you are adverse to working hard or have a problem with self motivation, this is not the place to be.
Advice to ManagementAdviceFocus solutions & approach from the transaction down versus primarily on the storage. The cloud approach is 100% about the transaction.
"Good company, strong organizational culture "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I worked at EMC full-time (more than 3 years)
ProsManagement ensures that there is a razor sharp focus on achieving results. Not afraid to spend money to meet customer needs
ConsLargely a power-based culture, with many small decisions being made at more senior levels. Lots of measurements, many of which are useful, some of which seem to be there just for the sake of gathering numbers.
Advice to ManagementAdviceYou've got a reputation for downsizing organizations, on occasion, a little too hastily. But you know that already, I suspect.
RecommendsPositive OutlookApproves of CEO -


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People Pets
Pets Shop 'Til They Drop!Who says Black Friday and Cyber Monday are just for humans? These dogs want in on the fun, too
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- These Men Cleaned the Boston Marathon's Finish Line Mid-Blizzard


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Tallahassee, FLUSA 32301
May 6, 2013
My name is Larry and I like to play games :)
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Buffalo Wild Wings picks site for state's first PizzaRev
- John Vomhof Jr.
- Staff reporter/broadcaster- Minneapolis / St. Paul Business Journal
- Email | Twitter | LinkedIn | Google+
Buffalo Wild Wings Inc. has selected the site for its first PizzaRev location in Minnesota.
PizzaRev has signed a lease for a 2,400-square-foot space at Knollwood Crossings in Hopkins, according to Steve Johnson, a principal for developer Solomon Real Estate Group. Buffalo Wild Wings (NASDAQ: BWLD) bought a minority stake in the pizza chain in March and owns the franchise rights for Minnesota.
Five Guys Burgers and Fries and Sprint are already open at Knollwood Crossings, located at 525 N. Blake Road, across Highway 7 from Knollwood Mall. PizzaRev, Jersey Mike's and Yogurt Lab are all under construction.
PizzaRev will likely open in December, Johnson said.
PizzaRev is billed as the Chipotle Mexican Grill of pizza. Customers pick out toppings and get a cooked pizza about three minutes later.
During Buffalo Wild Wings' third-quarter earnings call this week, CEO Sally Smith said the company plans to open two PizzaRev franchises in the Twin Cities by early 2014.
The chain currently operates five restaurants in the Los Angeles area. Its website says another six California locations are "coming soon."
The PizzaRev investment is part of Buffalo Wild Wings' broader growth strategy of investing in emerging restaurant concepts.
Buffalo Wild Wings made other news this week, announcing plans for table-top tablets and a TV network in its restaurants.
John Vomhof Jr. covers retail, hotels, sports business, advertising, public relations and media. He's also on the air on WCCO-AM 830 with Dave Lee daily at 8:45 a.m. and on Fox 9 TV Fridays at 5:30 a.m. & 6:30 a.m.
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Peter Tcherkes
Game Credits
Design | ||||
The Last of Us (2013) | (Game Designers) | |||
Darksiders II (2012) | (Additional Design) | |||
Star Wars: The Old Republic (2011) | (World Design) | |||
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Neighbouring Sites
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NickiIts was a brilliant festival! I've got so many great memories of the whole weekend. Thank you for doing such a superb feature on Badfest.
Andrew CarrollI was there, on Friday, Saturday and Sunday. The best day for me was Punk Friday, and best of all, you captured me with the Pink Mohawk, watching the Itchy Tits! Thanks for covering this event, it has made it more memorable for me. The best band, in my honest opinion, performance wise: The UK Subs. Cheers
jamesgreat really well organised especially for children. the music was very good sham 69 were amazing


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Girls Tryouts are still on today Thursday – January 29th at 6pm despite minor sprinkles! Will see everyone at Rohr Park. Parents please arrive 20 minutes before to check in your child! Click the link for more info! http://rebelssc.com/youngers-tryout-information/
Academy changes to 4:15 – 5:15pm Monday, November 3rd
Fields are open today November 3, 2014. Rohr Park is open. Sessions begin below at following parks: Monday October 6 at Rohr Park; Tuesday October 7 Santa Venetia Park or Heritage Park. Pick the park and attend two sessions a week for 8 weeks from 4:30-5:30 pm. Go to the navigational bar and select Academy to […]
Rebels SC Partners with Coerver®
The Rebels Soccer Club has signed with Coerver® San Diego as one of the limited number of clubs working with the World's Number One Skills Development Method. With over 30 years of developing players, Coerver® has established itself as the top method for teaching skills. Coerver® is also one of the top methods for developing […]
ODP Selections Summer 2014
The Rebels would like to congratulate the following players for being selected to ODP this past summer:
2014 Summer Tournament Recap
West Coast August 2014 G9 – Flight 1 Champions G13 Flight 1 Finalists G8 Flight 1 Finalists B8 West Coast Finalists United Cup August 2014 B8 – Superliga Champions B17 – Champions G8 Finalists Pegasus Cup June 2014 G14 Black Pegasus Finalists G16 Pegasus Cup Champions B8 Champions
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U8 Girls Showing Their Ball Control Skills Dazzling Dribbling at State Cup Rebels Latest Promo 4 ISSA creative skill camp : Rebels CV Rebels vs Western AZ – BU14 Finals Notts Forest Memorial Day Tourney 2012 2012 Rebels vs Quest Selena Goal 4 Become a Rebel this Season Rebels Tryout Promo Video I
U9 Girls Win 2014 State Cup!
Local youth teams triumph at soccer championship (San Diego Union-Tribune) The Girls U9 won the Governors State Cup on February 16, 2014, after defeating the Del Mar Sharks 3-2 in San Bernardino. Their journey took them through nine games including winning in penalty kicks in the quarterfinals and sudden death over-time victory in the semifinals. […]
Coach Robert Martinez' U13 Girls are Crowned State Cup Champions!
This past Sunday the U13 Rebels Girls won the CalSouth Presidents Cup beating Granada United FC in penalty kicks 4-3. In the dying seconds of regulation time, trailing 1-0 since halftime, the Rebels equalized the game with a trick corner kick play. The ball dummied two Rebel players before being put in the net. That […]
Older Tryout Dates
Older Rebel Tryout dates and location are available here.
Awards Night For Our Presidio Winners!
U12 Girls AA-A Champions U14 Girls AA-A South Champions U15 Boys AAA Champions U8 Girls Green Champions U8 Boys Red Champions U11 Girls AA-B South Champions U13 Girls AAA -Champions U13 Girls AA-C South Champions U10 Girls AA-B South Champions U9 Girls Green South Runner-Ups U11 Girls AA-A South Runner-Ups U19 Girls AAA Runner-Ups U11 […]


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Orioles right fielder Nick Markakis just can't seem to stay healthy. MLB.com's Britt Ghiroli reports that Markakis will get an MRI on his bothersome neck on Monday.
"Just to be on the safe side on Monday," manager Buck Showalter said of Markakis, who last played March 1 and was improving until reaggravating the area on Thursday. "Monday or Tuesday. Think it's Monday."
Markakis was scratched from Sunday's lineup when he reported having a neck spasm that morning upon arriving at the team's facility.
2012 marked the first season in the 29-year-old's career in which he didn't play in at least 140 games. He played in 104, posting a .298/.363/.471 line. However, his 2012 was plagued with injuries as Markakis needed three different surgeries: his abdomen in January, his wrist in June, and his thumb in September.
The Wrigley Field renovation has sent a whole bunch of rats scurrying into the neighborhood
Jan 29, 2015, 3:30 PM EST
I guess it's better than snakes. Or wasps.
Quote of the Day: Rob Manfred and Jerry Reinsdorf's "f*****g cigars"
Jan 29, 2015, 2:04 PM EST
This is funny. But also insightful.
The 12th greatest GM of all time is the real "Moneyball" innovator, not Billy Beane
Jan 29, 2015, 11:30 AM EST
Brad Pitt was too young to portray him, though. Maybe Kevin Kline could've?
Rosenthal proposal: make relievers face more than one batter per appearance
Jan 29, 2015, 10:01 AM EST
He's gonna get big pushback from the LOOGY union, but is the idea a good one?
Keith Law Ranks the Farm Systems: Yay for Chicago! Boo for Detroit!
Jan 29, 2015, 7:58 AM EST
A glimpse into the future, you guys.


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How to keep a steady convo with your new BF
Plan your most productive day yet
Austin Mahone explains the delay on his debut album
Fun football-inspired noms...just in time for the Super Bowl!
5 celeb-inspired ways to style your leggings
Best date hair ever? Exactly how to nail the bouncy blowout this V-Day
Yummy and easy vegan meals to make ASAP
What's your alter ego?
Thoughts on our Feb/March issue? We wanna hear 'em!
Barbizon Passport to Discovery 2014: Meet Taylor!
More Friends = More Fun
GL Tweets !
3 HOURS AGO Late-night thought: A smooth sea never made a skilled sailor ⚓
4 HOURS AGO RT @ImRapunzelx: @girlslifemag @PeytonList slayton! 👌
7 HOURS AGO Your PJs might be causing you serious health probz: http://t.co/ki7ToXOWna
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Sure, prezzies and cards are great, but nothing takes the cake quite like, well, cake. But as much as I heart those luscious layers, I clearly can't throw a birthday bash on the daily just for a slice of sweetness. That's why I found subtle and adorbs ways to keep the b-day vibes going long after the candles are blown out.
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A portable piece of cake that won't mess up your purse? Digging for coins just got a whole lot sweeter.
Slice of Cake Pouch, $16, fredflare.com
Confession: I'm not a fan of sprinkles, whether they're on ice cream or cake. Rhinestone sprinkles on the other hand? Keep 'em coming!
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The Enchanted Cave 2
Delve into a strange cave with a seemingly endless supply of treasure, strategically choos
4.31 / 5.00 29,856 ViewsGhostbusters B.I.P.
COMPLETE edition of the interactive "choose next panel" comic
4.03 / 5.00 9,002 ViewsCreate a Sloth of your very own! There are different skin tones, hair styles, clothing, and backgrounds. The combinations are very large. Not accepting any more submissions.
Dress up a sloth.
This was a very good dress up to use with an already familiar (Goonies/These flash movies) character. A thing I noticed in this dressup was the ability to change the backdrops. I think that is a cool idea. The newgrounds t-shirt was neat too.
Rocky road?!?!
Every popular character has to have a dress up game to go with it! This is proof!
BTW, could use a few more of everything.
boring ZZZZzzzz
not bad ,it was kinda boring just dressing him up.You know ,your not the onlyone come up with that idea!


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Added June 26, 2014 9:09 PM
Category: Headlines
It sounds like the perfect birth control answer for millions of women who are done having children. Only that easy answer has also resulted in serious complications for thousands of women. #kelonews
-327 Minutes Ago
Women claim Essure causes debilitating health problems; their concerns and company comments tonight on #KELONews at 10.
-281 Minutes Ago
A man was rescued from Big Stone Lake after falling through the ice. #kelonews
-247 Minutes Ago


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Dulles Middle School News
8th Graders and their parents are invited to attend the Dulles High School Course Selection Night. Where: Rodgers Auditorium for a general meeting and DHS for the Course Selection Fair When: Monday, February 2 Time: 6:30-8:00 pm We will begin in Rodgers Auditorium at 6:30 and will then have break-out sessions to talk in smaller groups. Students and parents will be able to get information about all of the courses that we offer at DHS.
FBISD's Academy Expo takes place on Tuesday, January 27, 2015. Fort Bend ISD will host its annual Academy Expo on Tuesday, January 27, 2015 to give current eighth-grade (8th grade) students and their parents and/or guardians the opportunity to learn about the district's high school academy programs. The event will be held from 6:00 – 7:30 p.m. at Wheeler Field House (16403 Lexington Blvd., Sugar Land, 77479).Academies exist to provide specialized learning communities with concentrated and robust course pathways comprised of career and academic classes. The district currently offers the following high school academy programs:
DMS held its 2014-2015 Campus Spelling Bee on Wednesday, January 7, 2015 in which 1st, 2nd, and 3rd place winners were selected based upon their performances. The winners of the DMS Spelling Bee were: 1st Place - Marco Jonsson, 6th grade2nd Place - Shani Chiang, 6th grade3rd Place - Arshiya Shah, 6th grade A huge round of applause goes out to all of the participating students in the Spelling Bee for displaying such AWESOME talent! The DMS family is supporting our first place winner, Marco Jonsson, as he moves on to the District Spelling Bee to be held on Tuesday, February 17, 2015. Way to go Vikings! Please view our AWESOME DMS Spelling Bee Winners along with DMS supporting staff, Principal, Ms. Dee Knox, Spelling Bee Coordinator, Ms. Paulina Chyrk, and School Librarian, Ms. Dana Cox in the attachment below! Related Document
FREE Community Event: The STEMosphere "It's a numbers game. WILL DMS HAVE THE MOST REPRESENTATION?" Where: Ridge Point HSWhen: Saturday, Feb. 7Time: 9:00am – 4:00 pm A hands on, minds on playground for children and adults of all ages! Attendees can experience: * Building 40 foot towers with KEVA planks* Fingerprinting with Murder in the Oil Field* Creating alcohol ink coasters * 3-D Printing * Solar Telescope viewing* Indoor Planetarium * Rube Goldberg Project...And many, many more! THE CAMPUS COMPETITION IS ON!!! The campus with the GREATEST number of representatives in attendance at the STEMosphere will earn a shaved ice social for a family event night as designated by the campus administration! Students and parents will sign-in at the STEMosphere. For more information, please view the attached flyer and/or visit http://www.sharefairnation.com/events/ Related Document
If you have signed up for Family Access, you may easily view progress reports and report cards online. Here's how... Related Document
Dear Parent, Attached you will find a link and a copy of the State of Texas 2013-14 School Report Card for Dulles Middle School. This is a report required by the Texas Legislature and prepared by the Texas Education Agency. It has been sent to the parent or guardian of every child enrolled in a Texas public school. The report provides information concerning student performance on the State of Texas Assessments of Academic Readiness (STAAR), as well as information on student enrollment, class size averages, and financial expenditures. The information contained in the School Report Card is required by state law and is briefly described in the enclosed "2013-14 School Report Card Definitions." The report for our school may or may not have all the information described, because the information presented depends on whether the school is an elementary, middle, or high school. State law requires that the school report card display information about the state, the district, and the school. Where possible, the information must be reported by race/ethnicity and socio-economic status of the students and must include at least two years of results. The School Report Cards can be found online at: http://ritter.tea.state.tx.us/perfreport/src/2014/campus.srch.html Related Document
General Supply List for all grade levels and subjects: 2 Boxes tissues (to be given to first period teacher)2 packages pencils1 package pens (blue or black)notebook paper (4 packages-should be replenished throughout the year)2 glue stick1 box Washable markers1 pair scissors Fiskar metal pointed scissors1 package highlighters1 roll scotch tape (for use in Science and Social Studies)3 packages index cards (3X5 lined)1 pencil sharpener with cover1 12" ruler marked with inches and centimeters1 flash drive(preferably 2GB)1 3" white binder5 pocket folders with prongs5 spiral notebooks1 set tab dividers1 pencil pouch1 package of colored pencils1 germ-x or hand sanitizer wipes Additional information in regards to organizational supplies (binders, spirals, folders, etc.) needed for a specific class will be distributed the first week of school if needed.


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A complete list of healthy complex carbohydrates is extensive, states Common Sense Health, and includes beans (black, garbanzo, kidney, lima, navy, pinto, soy), split peas, lentils, dairy products (milk, eggs, cheese, yogurt), fruits (including avocado), vegetables, whole grains, nuts and seeds. Also on the list are all products that include complex carbohydrates, such as breads, cereals and pastas.
Carbohydrates are required for providing the energy needed for daily activities, explains List of Carbohydrates. The site lists simple carbohydrates, including products made with table sugar, corn syrup, fruit juice, honey or chocolate. The amount of carbohydrate intake needed varies with the individual. A low carbohydrate diet is recommended to maintain healthy weight, promote body fitness, prevent diabetes and avoid cardiovascular disease, states List of Carbohydrates.
Carbohydrates full of fiber are absorbed more slowly by the body, whereas refined and processed carbohydrates tend to spike blood sugar levels, producing a surge of energy followed by a metabolism crash, WebMD states. The difference between good and bad carbohydrates lies in the amount of fiber they include. Eating plant foods provides quality carbohydrates with fiber, which studies have shown decreases heart disease and helps prevent colon cancer. Cutting down on daily carbohydrate intake causes the body to burn fat as a secondary energy source.
Learn MoreSome people crave milk due to the opiod peptides contained in dairy products. Opiod peptides represent what are known as amino acid sequences. Opiod peptides impact the brain in a manner similar to opiates, like OxyContin and heroin.
Full Answer >Natural soy milk is full of protein, vitamins and minerals. However, soy does have a bad reputation for being unhealthy. It is up to consumers to weigh the benefits and negative effects and choose whether they wish to consume soy milk or not.
Full Answer >Some basic side effects of consuming soy foods include constipation, bloating and nausea, according to WebMD. More serious side effects include itching and a rash. Soy milk not designed specifically for infants may lead to nutrition deficiencies in newborn babies. Using soy as a substitute for milk allergies may be unsafe in children since soy milk may also lead to the same allergic reactions.
Full Answer >Examples of good carbohydrates include whole grains, such as brown rice, millet, whole rye, wheat bread, buckwheat and whole-grain pasta; fruits; vegetables; and legumes, such as peas, beans and lentils. According to WebMD, good carbohydrates are those that contain high amounts of fiber and are not processed.
Full Answer >


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A place for Canadians to talk about our beer and our beer culture. Drunkeness should be taken to /r/drunk. Beer porn is strongly encouraged provided the majority of the beer(s) in the picture are of Canadian origin. Cheers, eh?
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If you would like to have your beer related sub-Reddit or or blog added to this sidebar feel free to message the Mods about it!
Homemade & BC-centric beer advent calendar (x-post from /r/Vancouver) (self.beercanada)
submitted 1 year ago by nudiustertian
view the rest of the comments →
[–]vancookalexBritish Columbia 1 point2 points3 points 1 year ago (0 children)
I might get downvoted for this, but I'm all about making your own beer advent calendars, because the commercial ones thus far (at least last year's and the year before) have been disappointing. The Snowcase is also nothing special for what price equals more than 2 12-packs...I feel like they're selling at a premium because they offer a couple beers that aren't available normally. Phillips is inconsistant enough as is (if you're a local, remember when all of their seasonals tasted watery and metallic for a good while? Ruined the Double Barrel Scotch Ale for me.), so I feel the money is better spent on buying stuff you've never had (or really love) and make your own.
π Rendered by PID 13424 on app-63 at 2015-01-25 16:59:39.660666+00:00 running dea44aa country code: US.


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The Stolen Camera Finder is a new search engine developed over the past two years by programmer Matt Burns. His idea is to search the web for photographs that have a stolen camera's serial number embedded in the EXIF information. It uses two web crawlers — the first is a standard one that accesses Flickr's API, while the second is a Google Chrome browser plugin that silently runs in the background and peeks at the serial numbers of images on any webpage viewed. These serial numbers and URLs are stored in a database, and if you'd like to volunteer your browsing for this you can download the Chrome plugin here.
Hot Stories Top 100
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Random Stories


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Video Premier – Bob Wayne's 'Till The Wheels Fall Off' EPK
On Tuesday (5-22-12) Bob Wayne will be releasing his brand new album through People Like You Records called Till The Wheels Fall Off, and Saving Country Music is excited to premier for you the EPK introduction video for the album.
It was shot at the house of Andy Gibson, Hank Williams III's steel guitar and dobro player, and the man who recorded Till The Wheels Fall Off and all of Bob Wayne's albums.
When I recorded my first album Blood to Dust, I had about 30 songs written to choose from." Bob tells Saving Country Music. "The next two albums I recorded were a lot of older songs that I had in the bank. Then with the Century Media release of Outlaw Carnie we made kind of a "best of" album. I can tell you this, this album is EXACTLY where I'm at right now in life!"
Pre-order Till The Wheels Fall Off directly from Bob Wayne at CM Distro.
…or on Amazon.
Support SCM and start
your Amazon shopping here
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- julesb on Elizabeth Cook is Back After Some Needed Time Off


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The classic sweet treat also does double-duty as a fire extinguisher and a taxidermist's tool »
A candy hardener, a soap-foamer and a stopgap wine ingredient can soothe your pain »
Can you make someone become intimately close to you -- even fall in love with you -- in less than an hour? Just ask Arthur Aron »
GoPro founder Nick Woodman is on a high. In June, 12 years after strapping a disposable camera to his wrist in Indonesia, his company IPO'ed at a value of almost $3 billion (£1.86bn) »
WIRED.co.uk reviews the Fairphone »


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There are 70 million garages in the U.S. today, but according to a recent Gladiator GarageWorks (part of Whirlpool Corporation) consumer survey, many need organizational help. Only 40% of garage owners listed parking their car as the garage's primary use, with the same percentage referring to their garage as a storage unit or junkyard. To help Americans turn around their cramped garages, Gladiator brand has announced the Chaotic & Cramped Ultimate Garage Makeover contest, aimed at turning the most cramped garages into organized spaces. One Grand Prize winner will receive a Gladiator GarageWorks Ultimate Garage Makeover worth $10,000 and five first prize winners will receive a Gladiator Fold Away Work Surface valued at US$249.
Back to Daily News
Daily News
Dec 22, 2014: Whirlpool headquarters improvements start a new phase Dec 22, 2014: DOE's Building Technologies Office releases Roadmap for Emerging HVAC Technologies Dec 22, 2014: Variable-speed circulation pump enables new Miele lab washers Dec 22, 2014: The latest retail data breach: Staples Dec 22, 2014: Consumer Spending Index is at its highest point of the year
More Daily News>>
November 2014: Appliance Magazine Market Insight Annual Subscriptions November 2014: U.S. Appliance Industry: Market Value, Life Expectancy & Replacement Picture 2014 October 2014: Portrait of the European Appliance Industry September 2014: Appliance Industry Focus: HVAC


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Publications (179)1129.97 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: While small-molecule kinase inhibitors became the most prominent anticancer drugs, novel combinatorial strategies need to be developed as the fight against cancer is not yet won. We review emerging literature showing that the release of several ectokinases is significantly upregulated in body fluids from cancer patients and that they leave behind their unique signatures on extracellular matrix (ECM) proteins. Our analysis of proteomic data reveals that fibronectin is heavily phosphorylated in cancer tissues particularly within its growth factor binding sites and on domains that regulate fibrillogenesis. We are thus making the case that cancer is not only a disease of cells but also of the ECM. Targeting extracellular kinases or the extracellular signatures they leave behind might thus create novel opportunities in cancer diagnosis as well as new avenues to interfere with cancer progression and malignancy.Cancer Medicine 12/2014; -
Dataset: Nano Lett. 2011 Schoen Supplement
Dataset: nl100533c si 001
Dataset: Supplement
- [Show abstract] [Hide abstract]
ABSTRACT: Fibronectin is a globular protein that circulates in the blood and undergoes fibrillogenesis if stretched or under other partially denaturing conditions, even in the absence of cells. Stretch assays made by pulling fibers from droplets of solutions containing high concentrations of fibronectin have previously been introduced in mechanobiology, particularly to ask how bacteria and cells exploit the stretching of fibronectin fibers within extracellular matrix to mechano-regulate its chemical display. Our electron microscopy analysis of their ultrastructure now reveals that the manually pulled fibronectin fibers are composed of densely packed lamellar spirals, whose interlamellar distances are dictated by ion-tunable electrostatic interactions. Our findings suggest that fibrillogenesis proceeds via an irreversible sheet-to-fiber transition as the fibronectin sheet formed at the air-liquid interface of the droplet is pulled off by a sharp tip. This far from equilibrium process is driven by the externally applied force, interfacial surface tension, shear-induced fibronectin self-association, and capillary force-induced buffer drainage. The ul-trastructural characterization is then contrasted with previous FRET studies that characterized the mo-lecular strain within these manually pulled fibers. Particularly relevant for stretch-dependent binding studies is the finding that the interior fiber surfaces are accessible to nanoparticles smaller than 10 nm. In summary, our study discovers the underpinning mechanism by which highly hierarchically structured fibers can be generated with unique mechanical and mechano-chemical properties, a concept that might be extended to other bio-or biomimetic polymers.Biomaterials 10/2014; · 8.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The major mechanical function of talin is to couple the β-integrin cytoplasmic tails to actin filaments. A variety of β-integrin tails contain conserved binding motifs for talin, and recent research shows that β-integrins differ both in affinity to talin and preferences for other cytoplasmic adaptor proteins. While talin predominantly links β3 integrins to actin filaments within the peripheral cell adhesion sites, talin can become replaced by other integrin adaptor proteins through their overlapping binding sites on integrin tails. Although the NPxY motif in the β-integrin tail is important for talin recognition, our simulations suggest considerably smaller contribution for the NPxY motif in the force resistance of the talin-integrin complex than for the residues upstream of the NPxY. It might thus be possible for the NPxY motif to detach from talin and interact with other integrin binding proteins while the β-integrin still remains bound to talin. The epithelial integrin β6 reportedly activates latent TGFβ1, and we propose that its function may involve direct interaction with talin.Molecular BioSystems 09/2014; · 3.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: While cell-substrate adhesions that form between the protruding edge of a spreading cell and flat surfaces have been studied extensively, processes that regulate the maturation of filopodia adhesions are far less characterized. Since little is known about how the kinetics of formation or disassembly of filopodia adhesions is regulated upon integration into the lamellum, a kinetic analysis of the formation and disassembly of filopodia adhesions was conducted at the leading edge of β3-integrin-EGFP-expressing rat embryonic fibroblasts spreading on fibronectin-coated glass or on soft polyacrylamide gels. Filopodia β3-integrin adhesions matured only if the lamellipodium in their immediate vicinity showed cyclic protrusions and retractions. Filopodia β3-integrin shaft adhesions elongated rapidly when they were overrun by the advancing lamellipodium. Subsequently and once the lamellipodium stopped its advancement at the distal end of the filopodia β3-integrin adhesion, these β3-integrin shaft adhesions started to grow sidewise and colocalize with the newly assembled circumferential actin stress fibers. In contrast, the suppression of the cyclic protrusions and retractions of the lamellipodium by blocking myosin light chain kinase suppressed the growth of filopodia adhesion and resulted in the premature disassembly of filopodia adhesions. The same failure to stabilize those adhesions was found for the advancing lamellipodium that rapidly overran filopodia shaft adhesions without pausing as seen often during fast cell spreading. In turn, plating cells on soft polyacrylamide gels resulted in a reduction of lamellipodia activity, which was partially restored locally by the presence of filopodia adhesions. Thus filopodia adhesions could also mature and be integrated into the lamellum for fibroblasts on soft polyacrylamide substrates.PLoS ONE 09/2014; 9(9):e107097. · 3.53 Impact Factor -
Article: Patterning of supported lipid bilayers and proteins using material selective nitrodopamine-mPEG
[Show abstract] [Hide abstract]
ABSTRACT: We present a generic patterning process by which biomolecules in a passivated background are patterned directly from physiological buffer to microfabricated surfaces without the need for further processing. First, nitrodopamine-mPEG is self-assembled to selectively render TiO2 patterns non-fouling to biomolecule adsorption on hydrophilic and adhesive glass surfaces. After the controlled TiO2 passivation, the biomolecules can be directly adsorbed from solution in a single step creating large scale micropatterned and highly homogeneous arrays of biomolecules with very high pattern definition. We demonstrate the formation of fluid supported lipid bilayers (SLBs) down to the single μm-level limited only by the photolithographic process. Non-specific adsorption of lipid vesicles to the TiO2 background was found to be almost completely suppressed. The SLB patterns can be further selectively functionalized with retained mobility, which we demonstrate through biotin–streptavidin coupling. We envision this single step patterning approach to be very beneficial for membrane-based biosensors and for pattering of cells on a passivated background with complex, sub-cellular geometries; in each application the adherent areas have a tunable mobility of interaction sites controlled by the fluidity of the membrane.Biomater. Sci. 09/2014; - [Show abstract] [Hide abstract]
ABSTRACT: Early wound healing is associated with fibroblasts assembling a provisional fibronectin-rich extracellular matrix (ECM), which is subsequently remodeled and interlaced by type I collagen. This exposes fibroblasts to time-variant sets of matrices during different stages of wound healing. Our goal was thus to gain insight into the ECM-driven functional regulation of human foreskin fibroblasts (HFFs) being either anchored to a fibronectin (Fn) or to a collagen-decorated matrix, in the absence or presence of cyclic mechanical strain. While the cells reoriented in response to the onset of uniaxial cyclic strain, cells assembled exogenously added Fn with a preferential Fn-fiber alignment along their new orientation. Exposure of HFFs to exogenous Fn resulted in an increase in matrix metalloproteinase (MMP) expression levels, i.e. MMP-15 (RT-qPCR), and MMP-9 activity (zymography), while subsequent exposure to collagen slightly reduced MMP-15 expression and MMP-9 activity compared to Fn-exposure alone. Cyclic strain upregulated Fn fibrillogenesis and actin stress fiber formation, but had comparatively little effect on MMP activity. We thus propose that the appearance of collagen might start to steer HFFs towards homeostasis, as it decreased both MMP secretion and the tension of Fn matrix fibrils as assessed by Fluorescence Resonance Energy Transfer. These results suggest that HFFs might have a high ECM remodeling or repair capacity in contact with Fn alone (early event), which is reduced in the presence of Col1 (later event), thereby down-tuning HFF activity, a processes which would be required in a tissue repair process to finally reach tissue homeostasis.Matrix Biology 09/2014; · 3.65 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: An increasing body of evidence suggests important roles of extracellular matrix (ECM) in regulating stem cell fate. This knowledge can be exploited in tissue engineering applications for the design of ECM scaffolds appropriate to direct stem cell differentiation. By probing the conformation of fibronectin (Fn) using fluorescence resonance energy transfer (FRET), we show here that heparin treatment of the fibroblast-derived ECM scaffolds resulted in more extended conformations of fibrillar Fn in ECM. Since heparin is a highly negatively charged molecule while fibronectin contains segments of positively charged modules, including FnIII13, electrostatic interactions between Fn and heparin might interfere with residual quaternary structure in relaxed fibronectin fibers thereby opening up buried sites. The conformation of modules FnIII12–14 in particular, which contain one of the heparin binding sites as well as binding sites for many growth factors, may be activated by heparin, resulting in alterations in growth factor binding to Fn. Indeed, upregulated osteogenic differentiation was observed when hMSCs were seeded on ECM scaffolds that had been treated with heparin and were subsequently chemically fixed. In contrast, either rigidifying relaxed fibers by fixation alone, or heparin treatment without fixation had no effect. We hypothesize that fibronectin's conformations within the ECM are activated by heparin such as to coordinate with other factors to upregulate hMSC osteogenic differentiation. Thus, the conformational changes of fibronectin within the ECM could serve as a 'converter' to tune hMSC differentiation in extracellular matrices. This knowledge could also be exploited to promote osteogenic stem cell differentiation on biomedical surfaces.Biomater. Sci. 08/2014; -
Dataset: Movie M1
Dataset: Movie M2
- [Show abstract] [Hide abstract]
ABSTRACT: Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide labor during S. typhimurium infections. Here, we show that heterogeneous virulence gene expression in this organism also promotes survival against exposure to antibiotics through a bet-hedging mechanism. Using microfluidic devices in combination with fluorescence time-lapse microscopy and quantitative image analysis, we analyzed the expression of virulence genes at the single cell level and related it to survival when exposed to antibiotics. We found that, across different types of antibiotics and under concentrations that are clinically relevant, the subpopulation of bacterial cells that express virulence genes shows increased survival after exposure to antibiotics. Intriguingly, there is an interplay between the two consequences of phenotypic heterogeneity. The bet-hedging effect that arises through heterogeneity in virulence gene expression can protect clonal populations against avirulent mutants that exploit and subvert the division of labor within these populations. We conclude that bet-hedging and the division of labor can arise through variation in a single trait and interact with each other. This reveals a new degree of functional complexity of phenotypic heterogeneity. In addition, our results suggest a general principle of how pathogens can evade antibiotics: Expression of virulence factors often entails metabolic costs and the resulting growth retardation could generally increase tolerance against antibiotics and thus compromise treatment.PLoS Biology 08/2014; 12(8):e1001928. · 11.77 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Nanoshuttles powered by the molecular motor kinesin have the potential to capture and concentrate rare molecules from solution as well as to transport, sort and assemble them in a high-throughput manner. One long-thought-of goal has been the realisation of a molecular assembly line with nanoshuttles as workhorses. To harness them for this purpose might allow the community to engineer novel materials and nanodevices. The central milestone towards this goal is to expose nanoshuttles to a series of different molecules or building blocks and load them sequentially to build hierarchical structures, macromolecules or materials. Here, we addressed this challenge by exploiting the synergy of two so far mostly complementary techniques, nanoshuttle-mediated active transport and pressure-driven passive transport, integrated into a single microfluidic device to demonstrate the realisation of a molecular assembly line. Multiple step protocols can thus be miniaturised to a highly parallelised and autonomous working lab-on-a-chip: in each reaction chamber, analytes or building blocks are captured from solution and are then transported by nanoshuttles across fluid flow boundaries in the next chamber. Cargo can thus be assembled, modified, analysed and eventually unloaded in a procedure that requires only one step by its operator.Lab on a Chip 07/2014; · 5.70 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A simple and robust method termed "fiber-assisted molding (FAM)" is presented to create biomimetic three-dimensional surfaces with controllable curvature and helical twist. The alignment of muscle fibrils and the assembly of helically patterned extracellular matrix by cells demonstrate the potential of this method for tissue engineering and other materials science applications.Small 07/2014; · 7.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A straightforward strategy is presented for the site-specific incorporation of fluorophores or reactive probes into the extracellular matrix (ECM) protein fibronectin (Fn) by using the enzyme-catalyzed transamidation by activated factor XIII. Characterization by SDS-PAGE, western blotting, absorption measurements, mass spectrometry, and stepwise photobleaching for labeling quantification at the single-molecule level showed that the labeling was efficient and restricted to the N-terminal tails. The introduction of labels did not interfere with Fn fibrillogenesis, as verified by the incorporation of fluorescently labeled Fn into ECM and manually pulled Fn fibers. Site-specific incorporation of an azide was used to create a template for bioorthogonal click chemistry reactions in a second bioconjugation step, thus offering versatile modification and application possibilities in the context of matrix biology and tissue engineering.ChemBioChem 06/2014; · 3.06 Impact Factor -
Dataset: Klotzsch BiomaterSci 2014 supplement
- [Show abstract] [Hide abstract]
ABSTRACT: a Adsorbed proteins that promote cell adhesion mediate the response of cells to biomaterials and scaffolds. As proteins undergo conformational changes upon surface adsorption, their functional display may be significantly affected by surface chemistry or solution conditions during the adsorption process. A high-resolution localization microscopy technique is extended here to probe the conformation of individual fibronectin (Fn) molecules at the glass–water interface under physiological buffer conditions. To map dis-tances, four available cysteines located on the modules FnIII 7 and FnIII 15 of dimeric Fn were site-specifi-cally labeled with Cy3B, and their relative positions were determined by stepwise photobleaching with nanometer precision. The four labels on single Fn molecules did not show a uniform or linear arrange-ment. The distances between label positions were distributed asymmetrically around 33 nm with a tail towards higher distances. Exposure of Fn to denaturing solution conditions during adsorption increased the average distances up to 43 nm for 4 M guanidinium HCl, while changing the solution conditions after the adsorption had no effect, indicating that the observed intra-molecular distances are locked-in during the adsorption process. Also surface coatings of different hydrophobicity altered the conformational distribution, shifting label distances from a median of 24 nm on hydrophilic to 49 nm on hydrophobic surfaces. These results further highlight that the conformation of macromolecules at interfaces depends on the adsorption history. While illustrated here for surface adsorbed Fn, the power of localization-based microscopy extends the repertoire of techniques to characterize biomolecules at interfaces.Journal of Biomaterials Science. 02/2014; - [Show abstract] [Hide abstract]
ABSTRACT: Fibronectin is a globular protein that circulates in the blood and undergoes fibrillogenesis if stretched or under other partially denaturing conditions, even in the absence of cells. Stretch assays made by pulling fibers from droplets of solutions containing high concentrations of fibronectin have previously been introduced in mechanobiology, particularly to ask how bacteria and cells exploit the stretching of fibronectin fibers within extracellular matrix to mechano-regulate its chemical display. Our electron microscopy analysis of their ultrastructure now reveals that the manually pulled fibronectin fibers are composed of densely packed lamellar spirals, whose interlamellar distances are dictated by ion-tunable electrostatic interactions. Our findings suggest that fibrillogenesis proceeds via an irreversible sheet-to-fiber transition as the fibronectin sheet formed at the air-liquid interface of the droplet is pulled off by a sharp tip. This far from equilibrium process is driven by the externally applied force, interfacial surface tension, shear-induced fibronectin self-association, and capillary force-induced buffer drainage. The ultrastructural characterization is then contrasted with previous FRET studies that characterized the molecular strain within these manually pulled fibers. Particularly relevant for stretch-dependent binding studies is the finding that the interior fiber surfaces are accessible to nanoparticles smaller than 10 nm. In summary, our study discovers the underpinning mechanism by which highly hierarchically structured fibers can be generated with unique mechanical and mechano-chemical properties, a concept that might be extended to other bio- or biomimetic polymers.Biomaterials 01/2014; · 8.31 Impact Factor
Publication Stats
7k | Citations | |
1,129.97 | Total Impact Points | |
Top Journals
- Biophysical Journal (10)
- Langmuir (7)
- Proceedings of the National Academy of Scienc... (6)
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University of Pennsylvania
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Pittsburgh, PA, United States
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Zürich, Zurich, Switzerland
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University of Washington Seattle
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Seattle, WA, United States
Sandia National Laboratories
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Albuquerque, New Mexico, United States
University of Illinois, Urbana-Champaign
- • Department of Physics
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Urbana, IL, United States
California Institute of Technology
- Division of Chemistry and Chemical Engineering
Pasadena, CA, United States
Boston University
Boston, Massachusetts, United States


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Available in Black, Brick, Brown, Burgundy, ...
Classic in their clean wash and slim fit, these jeans are ideal for work and off-duty weekend looks alike. Complete with a five-pocket construction to easily keep things like your cash and keys organized, this will become your go-to pair for dressing and dashing (while still looking dapper). Zip fly Lightweight, woven 32" inseam, 32" waist, 10" rise Measured from Size 32 100% cotton Machine wash cold Imported Model Info: Height: | Waist: 31 | ...
Available in Black
Want to switch up your denim game with a subtle twist? The micro dot print on these clean wash skinny jeans is a step up from standard. Next time you're fishing through your denim drawer for something a little different, this pair will be there to lend your outfits a dose of laid-back cool. Five-pocket construction, zip flyLightweight, woven63% cotton, 36% polyester, 1% spandex32.5" inseam, 33" waist, 9.5" riseMeasured from Size 32Machine wash coldImported
Nothing beats a crisp pair of jeans to walk out the door feeling casually fresh and pressed! This pair ofclean wash skinny jeans seamlessly transitions from relaxed afternoons to the night life with the addition of moto jackets; you can rely on these any day of the week. Five-pocket construction, zip flyLightweight, woven98% cotton, 2% spandex32" inseam, 34" waist, 10" riseMeasured from Size 32/32Machine wash coldImported


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MINI Posts Highest Ever Worldwide Sales for September
Despite the economic climate in Europe being less than stellar, MINI continues to break sales records globally. Thanks in large part to its diversified product portfolio, sales broke the 30,000 barrier for the first time in September.
Official Release: MINI posted its best ever September sales with 30,562 vehicles delivered (prev. yr. 30,392/ +0.6%). The brand has also had its most successful first nine months ever – in the period up to and including September, MINI sold 223,214 vehicles, an increase of 7.2% in worldwide sales compared to the same period last year (208,223). Last month at the Paris Auto Salon, the company unveiled the MINI Paceman. The MINI Paceman is the world's first Sports Activity Coupe in the premium compact segment and it expands the brand's portfolio to seven models. The MINI Paceman is expected to provide further momentum for MINI when it arrives in the first half of 2013.
Written By: MF Staff
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BMW M3 SMG Vs. MCS
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Autocrossing the MINI Range


text:
1 Review
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Share your thoughts with other customers
Create your own review
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5.0 out of 5 stars
Lovely and warm,
By MB (Lancs, UK) - See all my reviews
Verified Purchase(What is this?)
This review is from: Ferguson Tartan Lambswool Scarf (Sports)
Bought for my dad for Christmas 2013, he loves wearing it so much he even wears it in the house! Not itchy at all, lovely and smooth against the neck and face, providing needed warmth in winter. Was worried that it may be too thin at first glance but the weave is very close and the wool particularly good at insulating, my dad has hardly taken it off since getting it!!
Highly recommended. |
Most Helpful First | Newest First
Ferguson Tartan Lambswool Scarf by Lochcarron of Scotland
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text:
For woodworkers at any level.
We will have the wood shop at Nova Labs open most Thursdays for an hour or more for whatever, your opportunity to meet other woodworkers and to take advantage of the shop.
Special features or class previews some weeks.
Look around the shop; find out about safety certification.
Talk about your projects and methods.
Learn about classes, group builds, and tool enhancements and maintenance.
Use the shop equipment, space permitting. If you are certified but not a member, the tools will be available. If you are not certified, get help from a shop steward.
I started the group because there wasn't any other type of group like this. I've met some great folks in the group who have become close friends and have also met some amazing business owners.
— Bill, started New York City Gay Craft Beer Lovers
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Scarecrow and Mrs. King1983 | TV Show
A handsome spy enlisted the aid of a spunky divorcée to help him with difficult cases. They worked well together---so much so that a romance developed, along with a double life for Mrs. King that often got complicated.
Premiered: October 3, 1983
Rating: None
Season 3, Episode 1 A Lovely Little Affair
First Aired: September 23, 1985
Amanda (Kate Jackson) is swept off her feet by a charming art restorer (Ben Murphy) she's assigned to tail---a man Lee (Bruce Boxleitner) suspects may be involved with terrorists. Sophia Vessi: Dominique Pinassi. Franco Necci: Pierrino Mascarino.
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Scarecrow and Mrs. King: Service Above And Beyond & Saved By The Bells
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Here's Dr. Mac's final batch of reasonably priced Apple related gadgets (and holders for Apple gadgets), all of which will be much appreciated by the geeks you love.
Report: Apple Pay is Disrupting and Transforming Mobile Payments
"Apple Pay has the ability to significantly transform the mobile payment space." That's the conclusion of an ITG Investment Report published on December 19. A major finding is that Apple Pay has been responsible for one percent of all digital payment dollars. This is a "strong showing" given that Apple customers must have the latest iPhones and the limited list of merchants. John Martellaro summarizes the report.
Apple Raises Prices in Russian App Store Amidst Ruble Meltdown
Apple has raised the price of apps in the Russian App Store in the midst of a meltdown in the value of the Russian ruble. The move follows Apple's decision earlier in the week to stop selling iPhones in Russia because of the volatility.
6-Ft MFi-Certified iOS Lightning and micro USB Convertible Charging Cable: $21
If you live in a multi-platform house, we have a deal for you on a 6-foot charging cable that's convertible between microUSB (for Android devices) and Lightning (for iPhones, iPads, and iPod touch). Better yet, the converter is actually attached to the cable, eliminating the chance to lose it! That's clever, and I like clever. It retails for $40, but you can get it through our deal for $21.
Apple Pay Expansion Worldwide Will Have Vast Repercussions
Apple Pay has been a huge success in the United States. The mobile payment purchase is supported by credit cards used for 90 percent of purchases. Now, thanks to a job posting that's been spotted, it seems Apple is ready to expand Apple Pay into Europe, the Middle East, Africa and India. The repercussions will be enormous.
iOS 8 Mail: Customizing Swipe Gestures
Apple's Mail app on the iPhone and iPad includes a couple handy gestures that let you flag messages, set them as read, or toss them in the trash. But what if those gestures don't do exactly what you want? iOS 8 lets you change them, and it's easy to do.
Netflix Says Offline iPad Viewing Not Going to Happen
Holding out for Netflix to bring offline content viewing to the iPhone and iPad? Don't hold your breath, because the company says that's not going to happen.
The Mac Observer Spin The Mac Observer Spin is how we show you what our authors think about a news story at quick glance. Read More →
This sure seems like a missed opportunity for Netflix, but maybe investing in new programming instead will worth it for the company in the long run.
Apple Pay Supporters Grow with More Retailers and Banks On Board
Apple Pay, the mobile payment system Apple introduced with iOS 8 and the iPhone 6, is quickly growing and is now compatible with cards that make up about 90 percent of credit card purchases in the United States. The list of companies and banks supporting Apple pay has continued to rise and includes Barclaycard, TD Bank North America, Albertsons, Staples, and more.
The Mac Observer Spin The Mac Observer Spin is how we show you what our authors think about a news story at quick glance. Read More →
Looks like Apple isn't having any trouble at all getting banks and retailers excited about Apple Pay.
iPhoneography 101: Photo Post Processing on Your iPhone
Add interest to your photos with these post processing techniques in this week's iPhonegraphy 101. Vern Seward runs through several techniques and apps you can use to take your photos to the next level, after you click the shutter.
Iowa Ready to turn Your iPhone into Your Driver's License
Your iPhone can already serve as your credit card, and Iowa is hoping it'll be your driver's license soon, too. The state is working on an app that shows your driver's license on screen that it hopes will be available in 2015, although privacy concerns may delay its launch.
The Mac Observer Spin The Mac Observer Spin is how we show you what our authors think about a news story at quick glance. Read More →
Digital driver's licenses on our iPhones seems like a natural next step now that Apple Pay is available. Hopefully Iowa can work out privacy concerns, and its program becomes a template for other states.
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Top Tactics for Transitioning into New Markets 12/22/2011 - Todd Muscato of Barcodes Inc offers best practices for solution providers looking to break into new markets. Learn about the challenges inherent in moving into a new vertical and how to train your salesforce for the transition.
A Blueprint for Elevating Service and Support 12/15/2011 - Phil Verghis of the Verghis Group explains how the services and support side of a VAR business is changing as solution providers transition from the break/fix model, and how the rise of SaaS has made a huge difference in how solution providers run their businesses.
Surefire IT Solutions for the Healthcare Market 12/15/2011 - SATO America talks about how VARs can educate healthcare providers about patient identification tools, the technologies a facility needs in order to upgrade its existing system, and best practices for solution providers considering transitioning to the healthcare market.
Why VARs Should Partner for a Total Solution 11/30/2011 - Concerntrak's David Rosenthal and Compsee's David Shepardson explain how the two firms collaborated on a robust food traceability tool, and the benefits they achieved through partnering. Learn how they adapted their software and hardware technology to build a true value-added solution, and the challenges and advantages of IT partnerships.
Why Your New Client Recruiting Tactics Must Change 11/17/2011 - Brian Offenberger of Right On, No Bull Marketing talks about how solution providers can attract new clients. Learn when and why "word-of-mouth" marketing makes sense, the benefits of a multi-channel lead generation approach, and the amount of resources VARs should invest in client recruitment efforts.
Best Practices for Building A Mobile Solutions 10/31/2011 - MIT System's Jim French explains how solution providers can work with ISVs and vendors to implement mobile technology into their product portfolio, and what to look for when selecting a partner. Learn how the tablet revolution is changing the way ISVs and VARs are working with hardware manufacturers to create stable and powerful solution.
How to Incorporate Cloud Computing Into A VAR Business Model 10/27/2011 - Scott Langdoc, CTO, PAR explains how the reseller market has reacted to the growing demand for cloud applications, which verticals are best suited for cloud solutions, and how solution providers can transition existing software offerings to a cloud platform.
Where Solution Providers Can Turn for Financing 10/26/2011 - Tim Lowe, director of consulting for Amazon Consulting talks about the challenges resellers face trying to access credit, places VARs should look for financing, and how to work with distributor partners to extend capital.
Best Practices for Solution Providers Implementing SaaS 9/30/2011 - Will Atkinson, president of CAP Software explains why solution providers should consider selling a software as a service model, and what verticals are best suited for SaaS integration. Learn how services can compliment a traditional hardware bundle and what needs to change to incorporate SaaS into your business plan.
From Break/Fix to SaaS: Why It Pays to Transition 9/20/2011 - In this Business Acumen podcast, Tony Serino, President and CEO of Serino Channel Services, explains why and when solution providers should consider altering their business models and the challenges inherent in moving to a services-based model.
Trapped in the Payments Maze? 12/5/2014 Payment technology is today's great disruptor. Merchants and solution providers alike are trying to navigate the twists and turns of payment processing. VSR sat down with Datacap Systems, Merchant Warehouse and ScanSource to talk about some of the hottest topics in payments today, including how solution providers can help SMBs through the EMV migration, the impact of a data breach, tokenization and more. Download Now >
NEC Debuting Retail Software, POS with Biometrics at NRF 2015 NEC will showcase an integrated POS, along with biometric-enabled retail solutions at NRF 2015.


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The Milwaukee Brewers will hold their final block party of the season tomorrow at Hart Park from 11 to 1 p.m.
Players and coaches scheduled to attend include Ryan Braun, Mike Burns, Todd Coffey, Craig Counsell, Brad Fischer, Trevor Hoffman, Jason Kendall, Felipe Lopez, Ken Macha, Willie Randolph and Mitch Setter. They are scheduled to appear between 11:30 a.m. and 12:30 p.m. and the appearance schedule is subject to change.
Bernie Brewer and the World Famous Racing Sausages will also make an appearance and the events will be emceed by Bill Michaels and Jeff Falconio of Newsradio 620 WTMJ-AM. Raffle prizes feature Brewer tickets, game-used memorabilia and other autographed items will be given away.
The latest Brewer apparel will be available in the merchandise tent and free hot dogs, soda and potato chips will be available compliments of Klements, Pepsi and Sportservice for approximately 300 people.
For further information check out brewers.com/blockparty.
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Category: "Social"
- Twitter Ads Make an Appearance
- Forrester Report Suggests Marketers Still Spend Peanuts on Social Media, But Increases Planned
- Robert Scoble's New Job? Working for Me!
- Microsoft Bottoms Out in Search Race
- Twitter Addicts, this Post is For You!
- Google Reader Now Hosts Conversations
- Google Calendar Available Offline
- CylonLab cyber security incubator launches in London, aims to link startups with UK government (Sarah Spickernell/City A.M.)
- Armed With A Push-Bike And $25 Million, Europe Beckons For Premium Take-Out Service Deliveroo (Steve O'Hear/TechCrunch)
- Alibaba Q3 net income fell 28% to $964M, misses estimates as Jack Ma invests in apps, shares fall 8% in pre-market trading (Lulu Yilun Chen/Bloomberg Business)


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Written on: 21/07/2010
cheap and easy to upload and collect from local store but dreadful quality - got them all reprinted with snapfish and much better results. pay a few extra pence per photo and use a different service
Written on: 20/09/2012
I ordered a photo canvas for my brother in laws first anniversary, I ordered this online and went to collect from my nearest store. I went to pick it up after 7 days later as that was the waiting time. On arriving home I opened it to find a grey line going straight across the top of the picture. Had to take this back really wasn't happy with the service I recieved at all
As rated by real users
" No contact from customer service after complaint email. " Read More
" Nothink if i could put less than nothink i would. " Read More
Written by chelsea2003
" Boots photo - utter rubbish, unhelpful customer service " Read More
Written by janehick
" Never again " Read More
" Never any stock " Read More


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Savannah turns pregnant when she went to a party after the school year finished and now that she's going back she runs into her baby daddy who doesn't even know her name let alone that she's pregnant. She also finds out that the dark haired, green eyed man who got her pregnant has a secret of his own!
13 days ago
Why are u wearing a tight shirt? People are going to see your belly and freak out
24 days ago
@SqueekyJumper13 I didn't know that, I don't understand jokes I have autism so I am learning jokes but it was because I didn't hear you say it with a tone of voice that tells me it was a joke, sorry for annoying you.
a month ago
Just for all of you who are getting mad, I'm warning you new readers in advance. I was somewhat of a grammar nazi when I read this book. I might have corrected ALL or almost all up until Chapter 16ish. Now you've been warned. Get angry if you'd like.
2 months ago
It cold be... Eer, EVERYTHING WENT BLUE!!! (Navy blue coz that is close to black but not black!) ( ^ω^ )


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Line breaks: jeal|ousyPronunciation: /ˈdʒɛləsi
Definition of jealousy in English:
noun ( plural jealousies)
The state or feeling of being jealous: a sharp pang of jealousy [ count noun] : resentments and jealousies festered
More example sentences
- I wonder if their fear is really jealousy and resentment at the initiative of today's generation.
- It deals with envy and jealousy and how these emotions cause so much unnecessary suffering in our lives.
- Sometimes Sara looks at Sarah's school friends and feels a pang of jealousy, of anger.
envy, enviousness, covetousness, desire;
informal the green-eyed monster
suspicion, suspiciousness, distrust, mistrust, doubt, insecurity, anxiety;
apprehension about rivals, possessiveness, overprotectiveness
protectiveness, defensiveness, vigilance, watchfulness, heedfulness, mindfulness, care, solicitousness, attentiveness
Middle English: from Old French gelosie, from gelos (see jealous).
Words that rhyme with jealousy
prelacyDefinition of jealousy in:
- US English dictionary
- English synonyms
- US English synonyms
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Pronunciation: apəˈθɛtɪk
showing or feeling no interest, enthusiasm, or concern


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