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Hydrokem Aerosols Limited is an independent, privately owned specialist aerosol company, which has been established for over 30 years. We manufacture a range of personal care, household, janitorial and specialty technical products. Product development resources are available with "concept to counter" support for novel products and ideas.
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Human genome interpreter Knome accelerates growth
- Julie M. Donnelly
- Reporter- Boston Business Journal
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The company was initially funded with $2 million from a private investor in 2008, followed by a $5 million investment from French life sciences company bioMerieux in April 2010. In October 2011, the company raised $10 million, split between bioMerieux and a private investor.
The company also brought in revenue from its service providing sequencing services to individuals willing to pay hundreds of thousands of dollars to learn more about their genetic makeup. Knome began building its sales force in late 2011, and is in the process of shifting its business mix to focus more on serving biotech and pharmaceutical companies.
Deals between genomics companies and pharmaceutical companies are heating up, as pharma seeks to develop companion diagnostics that can help identify the best patients for their drugs.
"One-third of specialty pharmaceutical companies' platforms are oral cancer drugs and many of those are targeted to specific genetic mutations," Ken Beers, senior manager for Burlington-based pharmaceutical consultancy group Putnam Associates, said.
"You are going to be able to charge higher prices and achieve better access to patients if you have a diagnostic to go along with it."
In addition to Roche's highly publicized pursuit of Illumina, other pharmaceutical companies are also launching multiple collaborations on a smaller scale.
For instance, French drugmaker Sanofi (NYSE: SNY) announced two partnerships with genomics startups in Massachusetts this past January.
"I think anybody that's going to be in research and development has to have some genomics capability," Sanofi CEO Chris Viehbacher said in an interview. "My personal opinion, it's an area of science that's evolving so rapidly and it could evolve anywhere, so you're better off doing it through partnerships."
Tolar would like to see the company enter into additional partnerships and said he wouldn't rule out an acquisition. He is considering an IPO in the next year or two, once revenue reaches at least $20 million.
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Publications (136)649.74 Total impact
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ABSTRACT: Objectives: Better treatment strategies and therapeutic options have changed the treatment of rheumatoid arthritis (RA) during the past decade. Our objective was to examine clinical and patient-reported outcomes in patients with RA treated in 1998-99 and 2011-12. Method: The cross-sectional observational study included 303 consecutive outpatients (n = 103 in 1998-99 and n = 200 in 2011-12) from the same outpatient clinic. Patient questionnaires included patients' sociodemographics, the Health Assessment Questionnaire (HAQ) for functional ability, the Nottingham Health Profile (NHP) for health-related quality of life (HRQoL), self-reported general health (GH), and operations performed due to RA. A clinical examination was conducted for all patients. Comorbidities according to the Charlson Comorbidity Index (CCI), anti-rheumatic drugs and medications were recorded and the HAQ and NHP dimensions calculated. The results from these two patient cohorts were compared. Results: The cohorts were comparable with regard to age, sex, and RA duration while the patients in the 2011-12 cohort were less often seropositive for rheumatoid factor (RF), had a better socioeconomic situation, better functional and working ability, and a decreased rate of RA surgery. The patients in 2011-12 had higher comorbidities and poorer GH while the HRQoL dimensions did not differ between the cohorts except for better mobility in 2011-12. Methotrexate (MTX) and combinations of conventional anti-rheumatic drugs were more frequently used in 2011-12. Biologicals were used only in 2011-12. Conclusions: According to our results, more active anti-rheumatic therapy coincides with better RA-related outcomes. However, the result was the opposite with regard to overall health and comorbidities. Is this a new challenge in the treatment RA?Scandinavian Journal of Rheumatology 12/2014; · 2.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Objectives: To assess the impact of abdominal obesity (AO) on disease severity, cardiovascular risk factors, and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA). Method: Two hundred and thirty consecutive outpatients were cross-sectionally assessed. Waist circumference (WC) with a cut-off point of ≥ 102 cm in men and ≥ 88 cm in women indicated AO. Clinical assessment included joint counts, radiographs of small joints, and laboratory tests. Comorbidities and medication were verified from the patients' database. Patient questionnaires included sociodemographics, pain intensity, global disease activity, the Beck Depression Inventory (BDI), the Health Assessment Questionnaire (HAQ), physical activity level, and the 36-item Short Form Health Survey (SF-36). Metabolic syndrome (MetS) was defined according to the criteria of National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). The association of AO with the 28-joint count Disease Activity Score (DAS28) and mental (MCS) and physical component scores (PCS) of the SF-36 and the HAQ was assessed by using regression models with the propensity score as a covariate. Results: The AO prevalence was 52% in the 200 eligible patients. In a univariate analysis, AO was associated with cardiovascular risk factors, low HAQ score, physical inactivity, disease activity parameters, impaired MCS, higher pain, and increased use of biological drugs and antidepressants. In a multivariable model, only poorer DAS28 (p = 0.018) and poorer HAQ score (p = 0.004) remained significantly associated with AO. Conclusions: AO is highly prevalent in patients with RA. In addition to cardiovascular risk factors, AO is associated with higher disease activity, higher disability, physical inactivity, more patients' perception of pain, and poorer mental health. Multifaceted promotion of lifestyle habits would be beneficial for improving AO-related health outcomes in patients with RA.Scandinavian journal of rheumatology 01/2014; 43(4). · 2.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background and purpose Drug-based treatment of rheumatoid arthritis (RA) has evolved markedly over the past 2 decades. Using nationwide register data, we studied how this has affected the rates of hip, knee, shoulder, and elbow replacement from 1995 to 2010. Methods The number of primary joint replacements was obtained from the Finnish Arthroplasty Register. To test the hypothesis that improvements in medical treatment of RA reduce the need for joint replacements, we also collected data about purchases of different disease-modifying anti-rheumatic agents (DMARDs) and biological drugs from the nationwide drug registers. Results The annual incidence of primary joint replacements for RA declined from 19 per 10(5) in 1995 to 11 per 10(5) in 2010. The decline was greater for upper-limb operations than for lower-limb operations. At the same time, the numbers of individuals using methotrexate, hydroxychloroquine, and sulfasalazine (the most commonly used DMARDs) increased 2- to 4-fold. Interpretation Our results are in accordance with observations from other countries, and indicate that the use of joint replacements in RA has decreased dramatically. Our data suggest that effective medical therapy is the most likely explanation for this favorable development.Acta Orthopaedica 08/2013; 84(4):331-7. · 2.45 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We describe the epidemiological and microbiological process in the clearing of a foodborne outbreak of Yersinia pseudotuberculosis O:1 linked to raw carrots and frequency of the associated reactive extra-gastrointestinal manifestations. The patient samples were investigated by routine culture or antibody testing methods. The real-time bacterial PCR was used to detect Y pseudotuberculosis in samples from the grated carrots and in those taken from the carrot storage. Genotype of bacterial isolates was determined by pulsed-field gel electrophoresis. For case identification, we retrospectively looked over the laboratory files of the central hospital focusing on the time period of the outbreak. Altogether 49 case patients were identified. Y pseudotuberculosis was detected by real-time PCR analysis in samples taken from grated carrots and from the carrot distributor. Bacterial isolates originating from the farm environment showed identical serotype (O:1) and genotype (S12) with the patients' isolates. Among 37 adults, reactive arthritis (ReA) was found in 8 (22%) and three adults had probable ReA. Six (67%) out of nine human leucocyte antigen (HLA) typed patients with ReA were HLA-B27 positive. Erythema nodosum was found in 42% of the 12 children, whereas none of them had definite ReA. In this outbreak, Y pseudotuberculosis was for the first time detected in both patient and food samples. ReA was more common than earlier reported in the outbreaks associated with this pathogen; the reason may be that the previous outbreaks have occurred among children. HLA-B27 frequency was higher than usually reported in single-source outbreaks of ReA.Annals of the rheumatic diseases 07/2013; · 9.27 Impact Factor - Annals of the rheumatic diseases 11/2012; · 9.27 Impact Factor
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ABSTRACT: To study the efficacy and safety of once-monthly oral ibandronate in the prevention of glucocorticoid (GC)-induced osteoporosis (GIOP) in postmenopausal women with inflammatory rheumatic diseases. A randomized, double-blind, placebo-controlled, parallel-group study of 140 postmenopausal women was conducted. At baseline, the mean lumbar spine (LS) (L1-L4) bone mineral density (BMD) was normal or osteopaenic (T-score ≥ -2.0) and the patients were receiving treatment with 5-15 mg/day of prednisone equivalent. Patients were randomized 1:1 to receive either monthly oral ibandronate 150 mg or placebo for 12 months. All patients received vitamin D and calcium supplements. The primary endpoint was the relative change in mean LS BMD from baseline to 12 months. Mean LS BMD increased significantly by 2.6% and 3.2% from baseline to 6 and 12 months with ibandronate compared to 0.3% and -0.1% with placebo, respectively (p < 0.001). Comparable significant mean increases were also found in trochanter, femoral neck and total hip BMDs at 12 months. Reductions in the serum levels of bone turnover markers C-terminal telopeptide of type I collagen (sCTX), N-terminal propeptide of type I procollagen (P1NP), and tartrate-resistant acid phosphatase (TRACP) were significantly more marked in the ibandronate group than in the placebo group at 1, 6, and 12 months. Adverse events (AEs) were reported at a similar frequency in both groups. A higher proportion of serious AEs (SAEs) were reported in the ibandronate group without emergence of any single SAE. Once-monthly oral ibandronate provides a significant increase in LS and total hip BMD with an acceptable safety profile in postmenopausal women treated with low-dose GCs for inflammatory rheumatic diseases.Scandinavian journal of rheumatology 08/2012; 41(4):260-6. · 2.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The first patient entered the Rheumatism Foundation Hospital, Heinola, Finland in July 1951. From that point on, the hospital helped patients suffering from rheumatic disorders. Specialists in the hospital actively developed treatments and published a large number of scientific articles in international journals. The hospital was well known internationally among people working in the field. Progress in the development of disease-modifying medication (biological agents in particular) has dramatically improved the life of patients with rheumatic diseases, but all effective treatments may also have adverse effects. In this article, we briefly review the history of the Rheumatism Foundation Hospital, which was closed permanently in March 2010 due to bankruptcy. The economical difficulties were caused primarily by the progress made in disease-modifying therapy, which decreased the need of rehabilitation and operative treatment of patients with rheumatic diseases. It seems that a great success in biological agents can carry "serious adverse effects", which may kill hospitals. This is an important primary observation, which should be noticed when the future of specialised institutes is planned.Clinical Rheumatology 05/2012; 31(8):1151-4. · 1.77 Impact Factor - Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis 06/2011; 18 Suppl 1:224-5. · 2.51 Impact Factor
- Scandinavian journal of rheumatology 05/2011; 40(3):236-8. · 2.51 Impact Factor
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ABSTRACT: To investigate how inflammation and metabolic syndrome (MetS) are associated with adipokine levels in patients with inflammatory arthritis. Fifty-four female patients with arthritis were enrolled in the study. Twenty (37%) of these patients had MetS, which was diagnosed according to the definition of the International Diabetes Federation (IDF). Interleukin (IL)-6 and four adipokines (resistin, leptin, adiponectin, and adipsin) were determined by immunoassay. Healthy women with body mass index (BMI) between 22 and 25 kg/m(2) served as controls. The patients with arthritis had higher levels of resistin than the healthy controls. This difference was clear in patients without MetS (17.4 in patients vs. 10.8 ng/mL in controls, p < 0.001), and even higher resistin levels were found in the patients with MetS (20.7 ng/mL; p < 0.001 vs. healthy controls; and p = 0.095 vs. patients without MetS). In the patients with arthritis and MetS, resistin correlated positively with IL-6 (Pearson's r = 0.5, p = 0.03). Leptin levels were increased in arthritis patients with MetS as compared to healthy controls, but not in patients without MetS. The statistically significant difference between patients with MetS and controls remained when leptin was adjusted with BMI. Accordingly, adiponectin levels were lower in patients with MetS than in healthy controls (p < 0.05). Leptin, adiponectin, and adipsin did not correlate with the inflammatory cytokine IL-6 or with C-reactive protein (CRP). The results show that high resistin levels are associated with arthritis independently of MetS, whereas leptin is increased only in arthritis patients with MetS.Scandinavian journal of rheumatology 04/2011; 40(4):256-62. · 2.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Risk for amyloidosis in rheumatic diseases is associated with a long-lasting inflammation. To assess possible changes in the incidence of terminal uraemia due to amyloidosis associated with rheumatic diseases on a nationwide basis, we scrutinised the files of the Finnish Registry for Kidney Diseases for patients suffering from amyloidosis associated with rheumatoid arthritis (RA), ankylosing spondylitis (AS) or juvenile idiopathic arthritis (JIA) over the period 1995-2008. The registry has an estimated 97-99% coverage of all patients accepted for renal replacement therapy (RRT) in the country. Data on the consumption of antirheumatic drugs were collected from two sources: the Social Insurance Institution's Drug Reimbursement Register, and the Sales Register of the National Agency for Medicines from the above period. Altogether 264 cases were identified. Two hundred twenty-nine of them had RA, 15 AS and 20 JIA. When the total annual number of new admissions to RRT varied between 20 and 37 at the end of 1990s, it was under half of that from 2002 onwards. Over this period, the number of users of low-dose methotrexate (MTX) has increased 3.6-fold, the drug being the most frequently used disease modifying anti-rheumatic drug in Finland. The present nationwide series is the first to show that the incidence of end-stage renal disease due to amyloidosis associated with rheumatic diseases is decreasing. An obvious reason for this is intensive anti-rheumatic drug therapy.Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis 03/2011; 18(1):25-8. · 2.51 Impact Factor - Scandinavian journal of rheumatology 03/2011; 40(2):152-3. · 2.51 Impact Factor
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ABSTRACT: To assess long-term impact of RA on the HR-QoL in a cohort of working-age patients with early disease treated by a multidisciplinary team including early and active use of disease-modifying anti-rheumatic drugs (DMARDs). Fifty-five consecutive patients with RA who were naïve to DMARDs and glucocorticoids were assessed at baseline and at 6 months, 1, 2, 5 and 10 years. HR-QoL, disease activity, function, and joint destruction of hands and feet were assessed by using the Nottingham Health Profile (NHP) instrument, the 28-joint based Disease Activity Score (DAS28), the Health Assessment Questionnaire (HAQ), and the Larsen scores, respectively. GEE (generalised estimation equations)-method was used to evaluate longitudinal relationships between the HR-QoL changes and other variables. All NHP dimensions except social isolation improved significantly during the first six months and remained favourable up to 10 years. The most prominent improvements were seen in the dimensions for pain and emotional reaction (p<0.001). In longitudinal evaluation statistically significant associations (p<0.001) were found between the DAS28 and the NHP dimensions for pain, energy and emotional reaction, and between the HAQ and the NHP dimensions for pain, energy and mobility. The extent of joint damage had no statistically significant associations to the six dimensions of the NHP instrument. Early improvements in HR-QoL carried over the ten-year follow-up in patients with recent-onset RA treated with a multidisciplinary strategy including early and active DMARD therapy. HR-QoL changes were longitudinally associated especially with disease activity and function.Clinical and experimental rheumatology 01/2011; 29(1):65-71. · 2.97 Impact Factor -
Article: More evidence of declining incidence of amyloidosis associated with inflammatory rheumatic diseases.
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ABSTRACT: To assess the incidence, prevalence, and outcome of amyloidosis associated with inflammatory rheumatic diseases. An observational study was performed in the outpatient department of Kainuu Central Hospital from 1993 to 2007. The following criteria were used for the performance of abdominal subcutaneous fat aspiration (ASFA) and/or rectal biopsies: erythrocyte sedimentation rate (ESR) > 40 mm/h at two consecutive visits; and proteinuria (> 0.5 g/day) or serum creatinine > 150 μmol/L. Renal biopsy was performed when there was a high suspicion of amyloidosis in cases with negative findings in the above-mentioned biopsies. In addition, amyloid staining was used routinely for mucosal specimens taken in gastroscopy and colonoscopy. The patients were followed until death or to the end of 2007. New diagnoses of amyloidosis in the consecutive 5-year periods from 1993 onwards numbered 11, 3, and 5, respectively. During the study period, there was a mean annual incidence of amyloidosis of 1.8 [95% confidence interval (CI) 1.1-2.8)/100,000]. At the end of 2007 there were eight subjects with amyloidosis, giving a point prevalence of 12.0/100,000 (95% CI 5.2-23.6). Five patients out of the 19 underwent haemodialysis because of terminal uraemia and three of them also had renal transplantation. Overall, 12 (63%) patients died after a median survival time of 6 (95% CI 4-8) years, one-third from amyloidosis. The 5-year survival rate of the series was 67% (95% CI 41-86). Amyloidosis is rarely encountered today. ASFA or rectal biopsy facilitates its early diagnosis.Scandinavian journal of rheumatology 11/2010; 39(6):461-5. · 2.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: With the exception of a previous history of pulmonary sarcoidosis, a previously healthy 38-year old man developed a sudden unilateral metatarsal pain and gradually progressing osteoporotic, partly lytic metatarsal bone lesions. The patient received a bisphosphonate treatment. Clinical and radiological situation began to improve during the follow-up observation. The diagnosis was based on clinical picture.Duodecim; lääketieteellinen aikakauskirja 01/2010; 126(11):1317-21. - [Show abstract] [Hide abstract]
ABSTRACT: Infliximab is effective and well tolerated in the treatment of juvenile idiopathic arthritis (JIA). The aim of the present study was to measure circulating levels of inflammatory mediators in patients with JIA during treatment with infliximab. Eight patients with active JIA refractory to standard treatments were treated with infliximab (3-4 mg/kg) at weeks 0, 2 and 6 and thereafter at approximately 6-week intervals up to 24 weeks. All patients (n = 8) responded to the treatment. By 6 weeks of treatment the number of active joints had reduced from 16+/-4 (mean+/-SEM) to 4+/-1 (p<0.01) and C-reactive protein (CRP) levels had fallen from 31+/-8 to 8+/-3 (p<0.001). Infliximab treatment also reduced the serum concentrations of interleukin-6 (IL-6), myeloperoxidase (MPO), and soluble adhesion molecules ICAM-1 (intercellular adhesion molecule-1), and E-selectin. Tumour necrosis factor-alpha (TNFalpha) levels tended to increase while the concentrations of endogenous TNF antagonists (sTNF-RI and sTNF-RII) reduced in most patients during treatment. Infliximab reduced serum levels of IL-6, MPO and soluble adhesion molecules in JIA patients, producing a good clinical response to the treatment.Scandinavian Journal of Rheumatology 07/2009; 36(3):189-93. · 2.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the 2-year efficacy and safety of etanercept in patients with ankylosing spondylitis (AS). A 96-week open-label extension study, which followed a 12-week double-blind placebo-controlled trial, was designed to provide longterm efficacy and safety data, including radiographic outcomes, for patients treated with etanercept 25 mg twice weekly (NCT00421980). In all, 81 patients were enrolled (96% of the participants from the double-blind study). Key efficacy measures included improvement using the Assessment in Ankylosing Spondylitis 20% (ASAS20) criteria, the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Radiographic progression was evaluated using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) method. Paired t tests were used to test within-group changes from baseline. The percentage of responders, by ASAS20 criteria, remained relatively constant in patients who received etanercept during the 12-week double-blind study (60% at Week 0 and 83% at Week 96 of the open-label extension); more patients from the placebo group became responders after being switched to etanercept (23% and 74%, respectively). A similar trend was also observed using the ASAS40 and ASAS5/6 criteria, the BASFI, and the BASDAI. Most patients had no change from baseline in mSASSS values. Etanercept was well tolerated; the most frequent adverse events were injection site reactions (n=30; 37.0%) and headache (n=18; 22.2%), and the most frequent infections were upper respiratory tract infections (n=43; 53.1%) and flu syndrome (n=22; 27.2%). For 2 years, etanercept was clinically effective and well tolerated, with no unexpected safety findings.The Journal of Rheumatology 06/2009; 36(6):1256-64. · 3.17 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the evolution of functional and clinical outcomes over 11 years in patients with early rheumatoid arthritis (RA) initially treated with a combination of 3 disease-modifying antirheumatic drugs (DMARDs) or with a single DMARD. A cohort of 199 patients with early active RA were initially randomized to receive treatment with a combination of methotrexate, sulfasalazine, and hydroxychloroquine with prednisolone or treatment with a single DMARD (initially, sulfasalazine) with or without prednisolone. After 2 years, the drug treatment strategy became unrestricted, but still targeted remission. At 11 years, function was assessed with the Health Assessment Questionnaire (HAQ), and clinical outcomes were assessed with the modified Minimal Disease Activity (MDA) measure and the American College of Rheumatology (ACR) criteria for remission. At 11 years, 138 patients were assessed (68 in the combination-DMARD group and 70 in the single-DMARD group). The mean+/-SD HAQ scores were 0.34+/-0.54 in the combination-DMARD group and 0.38+/-0.58 in the single-DMARD group (P=0.88). Modified MDA was achieved by 63% (95% confidence interval [95% CI] 51, 77) and by 43% (95% CI 32, 55) (P=0.016) of the combination-DMARD group and the single-DMARD group, respectively, and ACR remission by 37% (95% CI 26, 49) and by 19% (95% CI 11, 29) (P=0.017), respectively. Initial therapy with a combination of DMARDs in early RA results in higher rates of patients achieving modified MDA and strict ACR remission even over the long term than initial single-DMARD therapy. Targeting remission with tight clinical controls results in good functional and clinical outcomes in most RA patients.Arthritis & Rheumatology 05/2009; 60(5):1222-31. · 7.87 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the utility of the Stanford Health Assessment Questionnaire (HAQ) in the estimation of loss of productivity due to early rheumatoid arthritis (RA) and to develop a simple model for analysis of the cost-benefit of therapies. In the Finnish Rheumatoid Arthritis Combination Therapy (FIN-RACo) trial, 162 patients with recent-onset RA who were available for the workforce were randomized to receive either a combination of three disease-modifying anti-rheumatic drugs (DMARDs) or a single DMARD for 2 years and were followed up for 5 years. No biological drugs were used. Data on sick leave and RA-related disability pensions came from official register records. Loss of productivity was computed by both the human capital approach (HCA) and the friction cost approach (FCA). Functional capacity was assessed by the HAQ at baseline and at 6 months. Over 5 years, mean loss of productivity per year was EUR 8344 by the HCA and EUR 1928 by the FCA. The level of the HAQ index at 6 months, but not the change in HAQ from baseline, determined productivity costs. With the HCA, a monotonous association between annual loss of productivity and the 6-month HAQ was found: EUR 2087 [95% confidence interval (CI) 1340-2903] per one step (0.13) on the HAQ scale from 0 to 1.88. With the FCA, the increase in loss of productivity was cut at the HAQ level of 0.5 to 0.75 (EUR 17 740 in 5 years). The HAQ index at 6 months may serve as a determinant of long-term RA-related indirect costs in economic analyses in early RA.Scandinavian journal of rheumatology 01/2009; 38(2):96-103. · 2.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To examine treatment induced changes in health-related quality of life (HR-QoL) in patients with early rheumatoid arthritis (RA). Changes in HR-QoL were assessed by the Nottingham Health Profile (NHP) instrument in 62 consecutive working age patients with recent onset RA with duration of symptoms of less than two years and naive with regard to disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids. Treatment-response was assessed by the criteria of the European League against Rheumatism (EULAR; 28-joint score; DAS28) at 6 months. NHP mean scores for pain (p=0.029) and emotional reaction (p=0.035) at baseline were related to EULAR response at 6 months, i.e. non-responders had the poorest baseline HR-QoL scores. When the patients were grouped according to EULAR response at 6 months there was a statistically significant mean linear change to better HR-QoL in NHP energy (p=0.0023), pain (p<0.001) and mobility (p=0.0085) from baseline to 6 months from the lowest to highest treatment-response level. Our results show that good treatment-response as measured by the EULAR response criteria translates into improved HR-QoL dimensions for energy, pain and mobility.Clinical and experimental rheumatology 01/2009; 27(1):108-11. · 2.97 Impact Factor
Publication Stats
3k | Citations | |
649.74 | Total Impact Points | |
Top Journals
Päijät-Hämeen Central Hospital
Lahti, Southern Finland Province, Finland
University of Tampere
- Medical School
Tampere, Western Finland, Finland
Pohjois-Karjalan Sairaanhoito
Yoensu, Eastern Finland Province, Finland
Central Hospital Central Finland
Jyväskylä, Province of Western Finland, Finland
Lapland Central Hospital
Rovanieni, Lapponia, Finland
Oulu University Hospital
- • Department of Surgery
- • Department of Physical Medicine and Rehabilitation
- • Department of Internal Medicine
Uleoborg, Oulu, Finland
University of Oulu
- • Department of Clinical Chemistry
- • Department of Internal Medicine
- • Department of Medical Microbiology
Oulu, Oulu, Finland
Turku University Hospital
Turku, Province of Western Finland, Finland
University of Turku
- • Department of Virology
- • MediCity Research Laboratory
- • Department of Medical Biochemistry and Genetics
Turku, Western Finland, Finland
Kuopio University Hospital
- • Department of Medicine
- • Department of Internal Medicine
Kuopio, Province of Eastern Finland, Finland
Kansai Medical University
- Department of Orthopaedic Surgery
Moriguchi, Ōsaka, Japan


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Leighton Meester on the Gossip Girl Set in NYC | Pictures
Leighton and Michelle Bring Fall Fashion to the Gossip Girl Set
Leighton and Michelle Bring Fall Fashion to the Gossip Girl Set
The ladies of Gossip Girl got to work on the streets of NYC yesterday. Leighton Meester was joined by Michelle Trachtenberg and Kelly Rutherford for an afternoon of filming in bundled-up Fall looks. It's back to business as usual for the cast, who recently celebrated costar Blake Lively's marriage on set. The wedding will be featured in the December issue of Martha Stewart Weddings, and Martha herself recently shared that Blake looked "very gorgeous" on her big day. Blake wasn't spotted in front of the cameras during the latest workday, though she has still been in the spotlight. Blake pregnancy rumors have swirled since her nuptials to Ryan Reynolds earlier this month, but her rep was quick to deny the news.
Stars on the Set
Gossip Girl
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Latest Articles
Chelsea's strikers will love playing with Juan Cuadrado if he does join, says Thierry Henry
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Chelsea's strikers will love playing with Juan Cuadrado if he does join, says Thierry Henry.
Premier League Manchester United Transfers: Van Gaal: Fletcher deal off
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Manchester United boss Louis van Gaal has said that Darren Fletcher's proposed move to West Ham is off.
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Bruce has already spent £15million on the capture of midfielders Robert Snodgrass and Jake Livermore, with a fee still to be decided by tribunal for winger Tom Ince.
But Bruce, who brought in Curtis Davies and Tom Huddlestone for relatively modest fees last summer, said he did not yet have the scouting network overseas to feel confident in signing more foreign players.
"There's the problem in our game. You identify a young English lad but you can get a player from overseas for half the price," said Bruce.
"If I can buy in our market I always will. You pay a premium for a young British player and that's what we've done.
"We've got a 22-year-old, a 24-year-old and a 26-year-old. It's cost us more money but I would expect that.
"You know what you're going to get. There'll come a time when I know what I'm going to get from the foreign market and hopefully we can get that set-up in the next 12 months."
Meanwhile, Bruce admitted talks to sign Tottenham centre-back Michael Dawson are "at a stalemate".
Bruce led Hull to Premier League safety and a place in the FA Cup final last season, an achievement which earned them a place in the qualifying competition for the Europa League.


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The future's in your paws. Shape it well. Roleplay in a cat Clan of warriors. Based off the Warriors series by Erin Hunter. Takes place during the time before the cats in the books existed.
warrior, #clan, cats, roleplay, riverclan, thunderclan, windclan, shadowclan, good, erin, hunter, warriors, active, portal, forum
Rise of the Night World
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Free forum : Bliss is an active, skilled and friendly clan. We are here to have fun and enjoy all the good moments. Time has come for Bliss to shine in Begone. Like a storm from above, or a bunch of
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This is the forum for our clan " Runners " talking there, so enjoy!
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Pokemon is for all but not all is for pokemon. Do you think you have what it takes to rise to the challenge?
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Free forum : Gaming Community
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TheLastKings clan is a clan on Duelingnetwork.com which hosts and supports the Konami based game, Yu-gi-oh! Based off the TV show.
lastkingclan, thelastkings, #clan, duelingnetwork, hosts, supports, konami, based, game, yu-gi-oh!


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Email Envelope Posters
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Book your room at Masseria S.D. di Manchisi
Mediterranean bed & breakfast in Monopoli with a complimentary breakfast
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Situated in Monopoli, this bed & breakfast is in the same area as Il Parco dei Dinosauri, Castellana Caves, and Museum of Contemporary Art. Area attractions also include Statue of Domenico Modugno and Cala Paura Beach.
Property Features
Masseria S.D. di Manchisi offers a complimentary full breakfast. Other amenities include a train station pick-up service, complimentary wireless Internet access, and free self parking.
Room Amenities
All guestrooms include climate control, hair dryers, and shared/communal kitchens.
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GoodLife Fitness
1 person found this helpful
"A good learning experience. "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I worked at GoodLife Fitness
Very flexible and it's great seeing people making positive changes in their lives.
Not all of the financial stuff is handled well and members complain a lot. It isn't for the weak of heart.
Prepare staff for possible confrontations/ problems and how to solve them .
"No work/life balance; sole focus on sales performance;constant job responsibilities added;long hours "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at GoodLife Fitness
ProsMotivate people towards fitness goals; observe fitness goals acheived; free membership at clubs;
opportunity for advancement within; education on changing negative outlook to positive.ConsLong hours; no work life balance; perform consistently regardless of extenuating circumstances;(ie: no staff) vacation times only during specific times of the year; different policies across the board depending on senior management; little concern for employees with children; 50 hr. work weeks; most management very young and inexperienced in real world issues. Management has no supervision; thus come and go as they please. Personal trainers are not paid unless training a member; doing free assessments until a member purchases a training package.
Advice to ManagementAdviceCreate reasonable shifts for management/sales staff. Pay trainers if they are working. Hold
2 sales meetings a day for reasonable shifts so mgmt. isn't there day and night. Have a manager
at the club start later in day to stay through the night to aid other staff during peak hours so they are
not left alone. Have policies with solutions; not just policies with textbook answers that don't apply.
Work/life balance. 50/55 hours a week to be successful is for people with no other responsibilities.Doesn't Recommend -
"Gives you no time for 'life' "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at GoodLife Fitness
Prosgood commissions if you work really hard
fun people
will get promoted fast (6mo-1yr) if you re successful at sellingConsREALLY long hours. 50-60/week or more
sales pressure from senior management
work weekends and late evenings
work end of the month with no over time to hit goalAdvice to ManagementAdviceGeneral Managers need more support in terms of more time off, reduction in sales goals


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Jesus Christ -The Seed Of The Woman. Isaiah 7:14 Therefore the Lord himself shall give you a sign; Behold, a virgin shall conceive, and bear a son, and shall call his name Immanuel.
Let us take you through the ancient Scriptural agenda from the court in Eden Gen.3:9-19 through to the future of our Great Lord and King Jesus Christ. Rev.22:12
Discover how The virgin birth of The Lord Jesus Christ was a sign given for mankind so as to believe that indeed, He is from above. What for and how does that concern you and the people around you? Listen abd be blessed.
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Best Summer Running Gear for Men
The 10 essentials in this late-summer lineup will ensure that you're equipped to chase down your personal best—no matter how high the mercury rises.
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- The Unique Health Benefits of Eight NutsCrack the health code.


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Man Show Kid Get a Date The Man Show Kid tries to get a date. Another classic! 4/28/2005 12:00:00 AM 406,143 1,083


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Uncertain Future: Ch. 8Chapter 8: Finally FreeBabi roared viciously and expelled another blast of flame at the Adepts below. Felix used Clay Spire to block the fires and whipped around to face Isaac."You, Mia, and Ivan get to higher grounds," he ordered. "Attack him from above. My sister, Piers, Sheba and I will stay here and wear it down.""You're the one who needs to live, Isaac," Jenna added when the boy opened his mouth to protest. "You're the one with the Star of Venus. And we all know that you're going to be the one to bring Babi down. Now go!"Mia and Ivan, approving of the plan, took Isaac by either arm and persuaded him to follow them.Piers chuckled. "I'm not sure that was the best move, Felix," he commented. "You just sent off our best chance at beating this thing.""We can't beat it," Sheba said dismally. "We can only weaken it for Isaac and the others. Shall we get to
Uncertain Future: Ch. 7Chapter 7: When Things Go AmissIsaac conveyed in a hushed tone the plan he had spent so long concocting but never had the resources or support to put into action. It was brilliant in its design, yet worthless without enough cooperating parties."We being tomorrow night," he began solemnly. "Felix, Piers, and Mia will start us off by disabling the surveillance cameras with their psynergy. Felix, you take the cameras in the soldiers' bunkers. Piers, head west, and Mia can go east. Jenna, do you still have all those sleep bombs that were left over?"The brunette girl nodded eagerly, glad that she hadn't disposed of her things as she once intended to do. "All right, good," Isaac continue, relief evident in his voice. "When Felix finishes with the cameras, he'll radio you. When he does this, Jenna, go into every room and use a sleep bomb. In fact, toss a couple in to m
Uncertain Future: Ch. 6Chapter 6: Isaac of Vale"Piers," Isaac breathed. He regained his composure and his expression hardened. "Just what are you doing?!""What am I doing?" the Water Adept repeated. "I could ask you the same. These people aren't trying to hurt you, and you—""They're not trying to hurt me?! Oh, is that what this is?" Isaac questioned sarcastically, gesturing to the bleeding wound through his shoulder. "This is them 'not trying to hurt me'? I had no idea!""Would you please stop?" Piers implored. "My patience has its limits. They aren't trying to hurt you. They just want to get rid of Babi. They don't know or care who you are."Isaac glanced over his shoulder at the battle raging. Many had already fallen. Many more were going down. Cries of agony and the stench of blood filled the air.
Uncertain Future: Ch. 5Chapter 5: As If From a DreamIsaac sighed and stared at the ceiling from his bed. Mia's question had provoked contemplation he didn't want or need. I'm Isaac of Vale, he told himself. I'm the Earth Adept who helped release Alchemy… I'm the hero that prevented Weyard from crumbling into oblivion…Somehow none of these portrayed him anymore. The hero that saved all of Weyard was also the hero that ruthlessly slaughtered countless innocents who had taken part in an uprising against Babi in Prox?"Agh, why did you have to do that, Mia?" he groaned. He had approximately a week left of his life. He needed to spend his precious time plotting his escape, not questioning his existence.There came a knock on his door. "Name yourself," he demanded, not feeling like getting up and crossing the room to answer the door. He received no more than another knock in rep
Uncertain Future: Ch. 4Chapter 4: The Mortality of InnocenceFor all his lack of ability to see or hear, Isaac's sense of feeling was left intact, though he currently begged of Gaia to take it away. A pain unlike any he had ever felt devoured either arm. Slowly the sheer darkness subsided and was replaced by the dim crimson of light filtering through the boy's eyelids. He realized that he only heard nothing because there were no sounds to take in.He opened his eyes with a groan and found himself lying upon the bed in his designated room. A glance at his arms, which were now rather numb, revealed them to be covered with four metal plates each. Upon closer inspection, he found that the plates were not merely resting atop his skin, but the edges continued beneath it. He winced at the notion of having slabs of metal beneath his skin, but it appeared to be the case.Foolishly he attempted to sit up and was reproved by a pain dozens of times


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In this episode of Wisconsin Foodie we travel to Door County to meet with Jesse and Rachel Johnson, owners of Door County Creamery. Door County Creamery is a goat dairy farm and creamery located in Sister Bay. We get a tour of the farm, meet their goats and then make our way back to the creamery to make fresh chevre. After a day of goat wrestling and cheesemaking, we pay a visit to Door County Brewery to meet with Owner John McMahon and discuss why he decided to open a brewery and what we can expect from their brews.
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- 5:26
- prompko
500000 views makes me smile Lashing out the action, returning the reaction Weak are ripped and torn away Hypnotizing power, crushing all that cower Battery ...
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ASUR - Battery /Official Music Video/
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Apple Watch battery, Whatsapp Web, Snapdragon 810 facts & more - Pocketnow Daily
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CNET Update - Panic sweeps nerd nation over Apple Watch battery life
- 3:0
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How To Make a 3 Penny Battery
Is there energy hidden inside your pocket change? Convert pennies into make-shift batteries that can drive small current devices like LED's and calculators. ...
Changing Batteries - The Saddest Story 3D Animation
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- "At the Vanishing Point" brings Louisvillians even closer together, if that's possible
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All posts tagged "USF"
Pitino's Cardinals defeat USF 80-54, win fifth game in a row
U of L won its fifth game in a row Tuesday night after defeating USF 80-54. Senior guard Russ Smith led the Cardinals in scoring with 19 points, also contributing five rebounds, two assists and...
- Posted February 19, 2014
Louisville routs USF
By Noah Allison The twelfth ranked University of Louisville men's basketball team rolled over USF 86-47 Wednesday night at the Sun Dome in Tampa, Florida stretching their conference winning streak to four games. Once again, U of...
- Posted January 23, 2014
Women's basketball improves to 16-1
By Sam Draut The fifth-ranked University of Louisville women's basketball team defeated USF 62-54 at the Sun Dome in Tampa, Florida on Sunday. The 16-1 Cardinals were led by senior guard Shoni Schimmel, who finished with 25...
- Posted January 13, 2014
Men's basketball AAC preview
By Dalton Ray CINCINNATI BEARCATS Mick Cronin's teams are known for rebounding on the offensive glass, long athletic defenders, and low percentage jump shooters. This year's team should fit the same mold and will be led...
- Posted November 13, 2013
Women's AAC Preview
By Dalton Ray CINCINNATI Cincinnati still has most of what it had a season ago. Seven players started double-digit games for the Bearcats and six of them return. One of the returnees is Dayeesha Hollins, who took...
- Posted November 13, 2013
Football improves to 7-1
By Sam Draut The number 18 University of Louisville football team defeated South Florida 34-3 on Saturday at Raymond James Stadium in Tampa. After being dealt its first loss last week, the 7-1 Cardinals were led by...
- Posted October 29, 2013
Pitino notches 650th win against USF
By Randy Whetstone Jr.– Coach Rick Pitino who was recently nominated for the Naismith Memorial Basketball Hall of Fame chalked up his 650th win against South Florida. He has coached 28 collegiate seasons to give him a...
- Posted February 19, 2013


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LLTC News
Join us on February 5th from 5-7 PM to learn and share perspectives about the Minnesota Food Charter.
Outreach & Recruitment
Karl Rangikawhiti Leonard, Maori artist, Master Weaver, and Fulbright Scholar visits LLTC for a cultural exchange June 16-20.
Wellness News
This Summer, Leech Lake Tribal College Staff and Faculty were challenged to take part in a Couch to 5k program hosted by the Wellness Center and Community Education at LLTC.
Advancement News
The BNSF Railway Foundation recently made a generous $25,000 commitment to The Leech Lake Tribal College Library Campaign.


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Written on: 01/06/2013 by DebzD (1 review written)
My brother and I went on the beginners trek today and we truly are beginners(I was a bit nervous). Many thanks for a fun and memorable afternoon. Ben really helped put me at ease and made me feel comfortable which meant a lot. Everyone else at the trekking centre were nice and friendly too but I didnt get chance to speak to them as much. would go again :)
As rated by real users
" Best ever " Read More
" Family fun AMAZING " Read More
" I could not it love it more " Read More
" The worst day ever!!! Do not go here at any cost !!!!!! " Read More
" Great riding school! love it loads... " Read More


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Additional Information
Rob Norman to head GroupM North America
LONDON - WPP has handed GroupM Interaction chief executive Rob Norman the additional role of chief executive of GroupM North America, providing a sign of its belief in the importance of digital expertise.
Norman will take over the role on 31 March from Marc Goldstein, who will be retiring after two years heading GroupM North America.
Management responsibilities will be shared between Norman and Rino Scanzoni, chief investment officer at GroupM, which is the pooled media buying operation of WPP's four media networks MediaCom, Mindshare, Mediaedge:cia and Maxus.
Irwin Gotlieb, global chief executive of GroupM, said: "Rob's background, combined with the direction the media marketplace is headed, makes him the perfect choice to lead GroupM in this region in the coming decade."
Norman created the new media division of CIA in 1994 and went on to become managing director of Mediaedge:cia's digital division Outrider, then chairman of Mediaedge:cia UK in 2003.
He relocated to the US in 2004 to develop MEC's worldwide offering, later becoming worldwide chief executive of newly created Mediaedge:cia Interaction and in 2006 worldwide chief executive of GroupM Interaction.
WPP chief executive Sir Martin Sorrell believes WPP's digital revenues, currently 25% of its overall revenues, will grow significantly over the next five years.
Last November he estimated that brands will boost their online spend to upwards of 20% of their media budgets by 2015.
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- Client Partner The Great & The Good £80000 - £90000 per annum + significant benefits, London


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Dynamic Content Software
- Page Counters
- Message Boards
- CGI Tools/Libraries
- CMS Systems
- Blogging
- Wiki
- Social Networking
- Ticketing Systems
Showing page 1 of 19.
dotproject mods dotproject mods is a repository for user community modules, addons, and enhancements for dotproject core project. The mods are supported by the author (not the dotproject team) but, if good, may be included in the dotproject core in future releases.
115 weekly downloads -
EnterpriseTimeSheet and Payroll This project provides a general solution to the payroll systems of any company. It provides web user clock in and clock out, has ip address (clock-in/clock-out) restriction, generate time worked, generate payroll slips, organizational chart, personel info
45 weekly downloads -
Apache XSLT web publishing module Apache module creates a web publishing environment by linking apache with Xalan XSLT engine. Makes a rule based transformation of xml and xsl files into html and caches the html page. Works with tomcat to support dynamically generated pages
55 weekly downloads -
PostgreSQL Diff Utility pgdiff is a utility which compares the table definitions of two databases, and returns the differences as PostgreSQL commands which will transform the structure of the first database to be identical to that of the second (c.f. diff and patch).
35 weekly downloads -
flatplanet A web atlas using the planetary body renderer, Xplanet. Explore the solar system. Overlay clouds, cities, weather forecasts, and more. Navigate by point and click. Search global databases.
22 weekly downloads -
Light HTTPD A project to improve ghttpd to include Server parsed elements, htaccess, content management, and in-page MySQL queries (Through SHTML-like tags).
12 weekly downloads -
PyChem A univariate and multivariate analysis UI. This project is no longer under development. Please use as you wish.
17 weekly downloads -
Domain Controller Domain Controller will let you manage all of you domains and clients online though a web browser interface giving you many options to choose from. Programmed in ASP
16 weekly downloads -
MySQL-Sync MySQL-Sync is a software which is build for synchronisize MySQL-dBases on different hosts. It is nearby portable to all MySQL-Versions. It runs on Linux and Win32 systems.
8 weekly downloads -
Compiere MFG + SCM (Manufacturing) Compiere MFG+SCM Manufacturing Extended System (MES). Include Shop Floor Control, Supply chain management, Quality management, modbus interface, iReport barcode extension etc. Support batch and on demand manufacturing. Works alone or connected to ERP.
9 weekly downloads -
GD4O [gee-dee-for-oh] GD4O is an OCaml interface to the GD graphics library. It provides OCaml developers a means to generate and manipulate bitmap images. TrueType fonts and antialiased drawing are supported. GD4O is based on OCamlGD 0.7, developed by Shawn Wagner.
8 weekly downloads -
retawq retawq is a multi-threaded web browser for text terminals on Unix-like computers. It is fast, small, nicely configurable and comfortable; e.g. you can keep open as many "virtual windows" as you want and work simultaneously in two of them.
7 weekly downloads -
Radi a light weight test director tool Application Radi-testdir is a light weight test Management tool. Radi supports testdirectory features like configuring the test plan, updating (create/edit) the test results for the test image/build, Backup, User Management.
4 weekly downloads -
A tool for modifying PDF forms This is a pre-alpha tool for modifying PDF forms written in C. It currently supports PDF versions 1.2, 1.3 and 1.4, which corresponds to Acrobat 3.0, 4.x and 5.x respectively. The program can currently handle text fields, checkboxes, and radio buttons.
1 weekly downloads -
NeuDist A Transaction Clearing Framework for developing Distributed Financial Applications
6 weekly downloads -
SheepWool A cross-platform, multi-lingual, Perl web-based content management system, designed with high flexibility and feature robustness in mind, and with the ambition to support as many databases as possible (Text files, DBM and fully relational databases).
6 weekly downloads -
etrdsy eTrdSy is an eShop : a Web-based Shop written in PHP 4, uses SQL-based Database (MySQL) - is User & Maintainer Friendly, Extensible, Scalable & Secure by Design.
6 weekly downloads -
ParaDB -- Paranormal Reporting Database ParaDB is a web-based (PHP/MySQL) application designed for use by ghost hunters and paranormal researchers. The software consists of a web-based interface for case management, client relations and investigative reporting.
2 weekly downloads -
qutexr QT-XMLRPC Library qutexr: QT-XML-RPC. A simple, easy to use XML-RPC library for QT. Uses QT's native classes to represent all XML-RPC types, so it is easy to use. Includes client and server objects and example code.
3 weekly downloads -
Abducted IRC Software A varity of IRC related services from: SMSServ Anope Modules/Modified Anope(AbAnope) to Unreal Modules/Modified Unreal(AbUnreal) to an IRC based RPG with addon packs, and web items: AbBash & PeerWars irc.abducted.us #abducted - http://dev.abducted.us
4 weekly downloads -
Interactive Music Server A project to develop a web-based, integrated management and distribution application for large-scale MP3 collections using PHP and using mySql.
4 weekly downloads -
Null iBBS Null iBBS is a Web-based Bulletin Board System with file bases, message forums, private messaging, Web mail, and a shared hyperlink system. This software is designed for semi-private online communities and user groups.
4 weekly downloads -
PHPhoto Viewer PHPhoto Viewer is a tool for dynamically generating web pages that display albums of digital photographs and photo captions. PHPhoto Viewer can be configured such that the appearance of generated pages matches the motif of any site.
4 weekly downloads -
babel.lib PHP components library babel.lib is Babel Com Australia's PHP Components Library, which we are releasing under an open source license for other PHP developers.
4 weekly downloads -
def2html def2html is a small and simple to use perl program for generating html files. def2html looks for one or more patterns and replaces them by the desired text. the generated text will be written into the file indicated at the beginning of the def
4 weekly downloads


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View asian Singles in Katy
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Land Rover LR3
macc24 Posts: 20Does anyone know, do some 2006 models have satellite radio and its just no initialized? If so , is there a way to enable this function? (Sort of like the old 99 Disco II's having heated seats installed but no switch to activate them)
I was told by my salesperson that I had satellite radio but now that I'm back from Alaska I clearly do not. Before I really lay into the dealership where I bought my LR3 I'm giving them a few days to respond to an e-mail I sent. I know someone earlier had posted a direct line to a LRNA rep...anyone have that e-mail address handy.
I also found out what was wrong with my fog lights, there was a short in my wiring for the front left fog light. Amazing what a difference in service taking your vehicle to a different dealer can make. I'm on 15,000 miles and that's been the only real glitch...(knock on wood)
P.S. - if you read my post wisely you'll probably have a good chance at what dealership I bought my LR3 from. -
british_rover Posts: 8,476If you have SAT radio then when you hit the AUX button a couple of times the SAT fuction will come up. If you don't have SAT radio then hitting AUX Over and over will only give you the AUX function in the radio head.
As far as I know there is no way to retrofit SAT radio into a LR3 that does not have it. -
british_rover Posts: 8,476
ssp1 Posts: 115But there are factory installed units meaning its an option if your vehicle has it or you order one made with one in it. Thats correct right? you just cant go after the fact and have them put it in. Which raises another issue; why dont all parts/service people who work for LR at dealers know this stuff? How hard can it be to know everything about one vehicle and be good at it (or three vehicles).
british_rover Posts: 8,476
stillwaters Posts: 33My 2006 V6 LR3 SE has the button on the radio for the bluetooth connection, but does not have the buttons on the wheel to answer the phone. When I push the Bluetooth button, a message comes up and says "no phone connected", but when I try to log in a phone, it doesn't connect. Is this button just for show? When I purchased my "new" LR3, the sticker was already off the window, so I do not know if it was supposed to come with this option in the first place...I am confused :confuse:
Keith -
dandrews1 Posts: 184I mostly use the command shift to downshift when coming up to a stop, or to slow down in traffic.
I'm no expert, but I've always done this in any automatic vehicle I've owned.. I find it helps slow down the vehicle, and in my mind, I feel I'm saving the brakes for a little more longevity. Also, these Rover brakes seem to throw off a lot of dust, so downshifting to slow down may help keep oxidization down on the rims. -
mark156 Posts: 2,000Dandrews1, when going down my street (25% grade or so), I use 2nd gear high. If I put the tranny in 'low', I will let it shift normally and it creeps even in 4th gear without touching the brakes.
Mark1562010 Land Rover LR4, 2013 Honda CR-V, 2009 Bentley GTC, 1990 MB 500SL, 2001 MB S500, 2007 Lincoln TC, 1964 RR Silver Cloud III, 1995 MB E320 Cab., 2015 Prevost Liberty Coach -
ssp1 Posts: 115I just reached 10,000 miles on my 06 LR3 SE7 and things have been great. I did have one alignment done at the 7500 mi check. And the speed sensitive auto wipers are noisy in light rainfall(i was told this is how it is and in S Cal thats what we have, fog like rain). Besides that the vehicle has been perfect. Its been everything I expected and a bit more.
morocco2 Posts: 43I mostly use the command shift to downshift when coming up to a stop, or to slow down in traffic
I use it for the same reasons including to cut down on dust brake especially on the front wheels. I also like to use command shift if I want a more involved driving experience mostly on country roads a light city driving when traffic is low. :shades: -
mac24 Posts: 3,910I mostly use the command shift to downshift when coming up to a stop, or to slow down in traffic.
Of course, this technique will require extensive re-training for most of the driving public, who seem to be under the impression that firm pressure must be applied to one pedal or the other at all times (and sometimes both). :shades: -
dandrews1 Posts: 184Of course, this technique will require extensive re-training for most of the driving public, who seem to be under the impression that firm pressure must be applied to one pedal or the other at all times (and sometimes both).
I agree - but even I do both when offroading (as I was taught that was the proper procedure when offroading automatic vehicles..)
mac24 Posts: 3,910(as I was taught that was the proper procedure when offroading automatic vehicles..)
Ah yes, true offroad driving is a whole different ballgame. Not so much specifically for automatic transmissions, but rather to get the most effective use from limited slip differentials (especially the worm geared type), that technique is generally referred to as BTM.......Brake Throttle Modulation.
Applying just enough brake to fool the diff into locking, while applying enough throttle to overcome the brakes and power the vehicle through. It's hard on the brakes and transmission, especially if you're late on the brakes when a wheel is spinning, but can be very effective. -
mark156 Posts: 2,000I really don't notice that much brake dust on my LR3. Now, my Mercedes does get a lot of brake dust as I clean my wheels almost everyday.
My friends DO make fun of me, but my wheels always look new and not pitted and scratched like other cars the same age.
One way to make your wheels shine, is to put a little bit of Black Magic Tire Wet on the alloy wheels and wipe off. It puts a nice shine on the wheels that will last until the next wash. Even "damp" cleaning to get the brake dust off leaves the wheels nice and shiny.
Mark2010 Land Rover LR4, 2013 Honda CR-V, 2009 Bentley GTC, 1990 MB 500SL, 2001 MB S500, 2007 Lincoln TC, 1964 RR Silver Cloud III, 1995 MB E320 Cab., 2015 Prevost Liberty Coach -
british_rover Posts: 8,476Another good trick to keep allow wheels shiny is to put a couple of good coats of wax on them. You will want to use one of high temp poloymer based waxes like Zanio or Zymol as a carnuba based wax doesn't have the high temp resistance you need on a wheel which is basicly a heat sink for your brakes.
Take the wheels off your car/truck and wax the whole thing. The wax will keep the brake dust and dirt from sticking to the wheel and you can wipe it off with a damp cloth.
Should last for a few months in normal conditions. -
mark156 Posts: 2,000BR, you think I'm going to take the wheels of my car? Ha ha haaaaaa!
Seriously, putting just a little bit of Tire Wet works great!
Actually, I did put wax on the LR3 when it was new (wheel wax at Autozone). I can't tell that it helped all that much to resist brake dust. Since I usually wipe my wheels down almost nightly, I never have much of a build-up anyway.
I wish I had the avenue to do "real" detailing.... I have no tools or the place to really do it.
Thanks for the suggestions! Mark1562010 Land Rover LR4, 2013 Honda CR-V, 2009 Bentley GTC, 1990 MB 500SL, 2001 MB S500, 2007 Lincoln TC, 1964 RR Silver Cloud III, 1995 MB E320 Cab., 2015 Prevost Liberty Coach -
mark156 Posts: 2,000SSp1, my wipers just don't seem noisy. But, my hearing is about 90% (too much disco music in the 70's, I guess)
Mark1562010 Land Rover LR4, 2013 Honda CR-V, 2009 Bentley GTC, 1990 MB 500SL, 2001 MB S500, 2007 Lincoln TC, 1964 RR Silver Cloud III, 1995 MB E320 Cab., 2015 Prevost Liberty Coach -
stillwaters Posts: 33My LR3 wipers are really noisy too. I am thinking of trying some Rain-X or something on them.
I have heard from several places thought that LR3 simply has noisy windsheid wipers and that I gotta "live with it"...
Otherwise I agree the LR3 is as close to PERFECT as an SUV can get. It seems almost an insult to call it an "SUV."
Keith -
dandrews1 Posts: 184I think it may have something to do with temperature.
I first got my LR3 in September, and things were fine, then it dropped below 10 degrees (celcius) and they started getting noisy.
anyone noticed their rear wiper not pressing hard enough against the window? I sometimes have to give it a 'shake' to gt it to re-seat properly. (by this I mean I lift it off the window to bend the arm at the joint, then let it snap back on the window..) -
morocco2 Posts: 43Actually the other day the temperature dipped down to -15 (celsius)with some light snow and I did not notice any change in performance. It seems to me, compare to other vehicles I have owned, that the heated windshield appears to help the performance of the front wiper blades under snowy and cold conditions. My rear wiper seems fine so far even when the temperature dips down.
koesler Posts: 57I just turned 20,000 miles on my 05 LR3 and have nothing to say except: WHAT A GREAT, WONDERFUL, AND PERFECT VEHICLE !!
I've had no problems except for a slight creaking noise when turning the steering wheel so the dealer replaced the "spiral casette" (whatever that is) and now it's smooth and quiet. My tires are showing even, normal wear although they are getting noisier. I've also had one instance where my front, right window would not close all the way until I lowered it, and closed it again (??).
I look forward to driving the LR3 much more than my other vehicles (Mercedes sedan, Toyota truck, and Mazda MX5 convertible) so each time I get to, it's just like Christmas all over again.
Wishing everyone Happy Holidays ! -
stillwaters Posts: 33My 2006 LR3 is one of four cars I own (besides my 2002 Dodge Ram Quad Cab, 2003 Pontiac Sunfire, and 1929 (replica) Mercedes SSK). I read the forums for all my cars and nowhere else but in the Land Rover forum do I pick up the absolute LOVE for a vehicle that Land Rover owners have for their cars...
The previous poster was right, just getting behind the wheel of the LR3 is a joy. This vehicle is a well thought out, tightly built, premium, go anywhere, quality machine.
I can't WAIT for it to snow!
Merry Christmas to you all and may we all keep in mind who's birthday we are celebrating...
Keith -
stillwaters Posts: 33


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John McCain 2008: TV Ad: "One Man" - Today's Christian Videos
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One man sacrificed for his country, opposed the flawed strategy for Iraq, had the courage to call for change, didn't play politics with the truth, and stands up to the special interests. One man does what's right- not what's easy. John McCain 2008
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Contour ROAM2 Camera
Great camera
I bought this camera so I could take videos of my trip to Canada. Used it for the river rafting and was very pleased with what I recorded. I would tell everyone to buy this!
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Oakley Kitchen Sink Backpack - Men's
Good for everything!
I love this backpack. It has a pocket for everything you can imagine. It is made of super heavy material that will last for ever. Everyone should own of of these!
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DAKINE Soho Wallet - Women's
I bought this wallet for Christmas presents last year and they were such a hit that i did it again this year.
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It's not just because spring's a good time to get the job done.
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Speakers Corner
It's free to register, to post a question or to start / join a discussion
Another annoying advert
Likes # 0
Posted October 21, 2011 at 7:01PM
We've just got rid of the video ad, now there's something (from Microsoft I think) rending the screen asunder and putting the two halves back together when you close it. Unfortunately for me, this action corrupts the screen slightly, but a refresh sorts it out.
Likes # 0
Posted October 21, 2011 at 7:15PM
I think were advertising guinea pigs, PCA uses us to demonstrate to advertisers know just how far they can go with an ad campaign before the red mist descends, and the benefits become outweighed by the advantages.
We're serving a vital function to the advertising industry...
Likes # 0
Posted October 21, 2011 at 7:36PM
QB - but we get lots of 'rewards' if we behave.
Likes # 0
Posted October 21, 2011 at 7:39PM
I've got the IE pop-up blocker on and tracking protection and that's it - but still no evil adverts show for me. I must be pure in heart.....
Likes # 0
Posted October 21, 2011 at 7:49PM
Spywareblaster stopped the annoying adverts on the side of the screen.I don't know how it works ...but it works.End of advert.
Likes # 0
Posted October 21, 2011 at 8:23PM
AitchBEE, interesting, it does show it blocks certain web adverts.
Likes # 0
Posted October 21, 2011 at 8:29PM
AitchBEE How do you know it was Spywareblaster that blocked it? Did you get a message or something to say so?
Likes # 0
Posted October 21, 2011 at 8:46PM
Spywareblaster is a blocker. It stops adware on a browser amongst other things. Most to do with active-x.
Likes # 0
Posted October 21, 2011 at 10:18PM
rdave13, yes I know, I've got it. Also got AdBlock+ and other 'tweaks' to block.
I just wondered how AitchBEE could be sure that it was Spywareblaster in particular that blocked it.
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