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Holloway named Ingalls V.P.
by MBJ Staff
Published: March 11,2012
Tags: Daniel Holloway, George Washingston University, Ingalls Shipbuilding, National Defense University, U.S. Naval Academy
Vice Adm. Daniel P. Holloway, U.S. Navy (Ret.), has been named vice president of customer relations for the company's Ingalls Shipbuilding division. In this capacity, Holloway will be responsible for all customer outreach for Ingalls programs. Prior to his most recent assignment, Holloway was on the chief of naval operations' staff as the director, Military Personnel Plans and Policy (OPNAV N13) at the Navy Annex in Washington, D.C.
Holloway graduated from the U.S. Naval Academy in 1978. He earned master's degrees in information management from George Washington University and in national security strategy from the National Defense University.
Holloway served as commander, USS Gonzalez (DDG 66), Destroyer Squadron 18 and Carrier Strike Group 12/Enterprise Strike Group. He also held various positions ashore, including the nuclear power officer recruiter at Naval Recruiting District, Philadelphia, and as an instructor and executive assistant for the chairman, Seamanship and Navigation Department at the U.S. Naval Academy's Professional Development Division.
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Aches, pains, and stress fall away at My Art My Passion Massage. Consider Evelyn Ogami the culprit. A licensed massage therapist, Evelyn comes with a toolbox of techniques ready to allay numerous symptoms associated with pain and tension. Here, you'll find treatments such as deep-tissue massage, which addresses chronic pain, barefoot shiatsu massage, and sports massage, a focused therapeutic treatment that can bring relief to those injured while on the playing field or fielding questions from aggressive reporters.
At Face It Permanent Make Up Center, a team of skilled micropigmentation specialists, each certified by the Society of Permanent Cosmetic Professionals, enhances faces with permanent makeup. Led by owner Edine Swain, who finds personal fulfillment in working with clients dealing with birth defects and scars from accidents or surgeries, the professionals take the time to talk with each client and understand his or her vision for elegant eyeliner or lips the color of a newborn fire engine.
While darkening brows or adding a starlet beauty mark, the artistic technicians employ micropigment colors—which, unlike traditional tattoo ink, don't acquire a bluish tint over time. They calibrate the pigment with the utmost care, blending hues to match a client's skin and hair or applying multiple shades of color to brows for a natural look. The professionals also specialize in correcting work performed at salons and in scar re-pigmentation, shading in the pale tissue left by surgical procedures or jobs as the Three Stooges' carpentry teacher.
Led by Pravina Kumar, a 22-year veteran of the beauty industry, the Threading Lounge staff uses its namesake technique to gently whisk away unwanted hair above the eyes and lip. Trained hands require a single cotton thread to perform the Asian technique, which isolates offending hairs without irritating the skin or accidentally flossing all the teeth. Threading requires no chemicals, sharp tools, or violent motions—clients simply relax into seats of plush, red cushions under the glow of a crystal chandelier. Threaded hair normally returns on the same timetable as waxed strands, and any length of hair may be jettisoned with the procedure, from peach fuzz to a yak's eyebrows.
Leina Keomalu can rehab mugs with an exfoliating facial, or draw on her lash certification to outfit eyelids an array of Kona lash services to fit customer's needs. Clients can also solicit the spa?s waxing services to nix unwanted hair from eyebrows, upper lips, or cherished pet rocks.

subset: commoncrawl


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Ratings based on 448 Verified Reviews
They paid and stayed. We double-checked.
4.5 Room cleanliness
4.4 Service & staff
4.5 Room comfort
4.3 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Everyoneby A verified travelerfrom Illinois
Nice hotel for the price.
Posted Jan 23, 2015Nice common areas, friendly staff, great restaurant ( though pricey) and a gorgeous room.
for Everyoneby A verified travelerfrom Illinois
Posted Dec 11, 2014This is the hotel that I stay with when I am down in the Collinsville area for work. The staff is awesome. Love the warm chocolate cookie that they give out when you check in. Hotel is in a good location and clean.
by A verified traveler
Bathroom not clean. Dust heavy.
Posted Nov 2, 2014Cons: Clean the rooms before someone stays in it especially if it has not been rented recently
Location: Location good
Toilet bowl clean, but the outside not clean. Dust everywhere and especially on the coffee pot and head board.
for Getaway With Friendsby Jutta
Posted Oct 26, 2014 on Hotels.com
for Overnight Stay Before Destinationby TJ
Posted Oct 26, 2014 on Hotels.com
Recommendedby Priscilafrom Brasil
Adorei o hotel
Posted Oct 9, 2014 on Hotels.comAdorei o hotel. Excelente atendimento. Quartos bem limpinhos e restaurantes bem proximos.
for Business Travelersby Williamfrom NY
average hotel , overpriced
Posted Oct 2, 2014 on Hotels.comHotel was nice, they have so issues the toilet was very slow and the door lock to enter the room, it was broken or needed replacing. (took me 7 times to Open the door) not worth the $180 room price. overpriced
for Personal Eventby Karen & Lenfrom Collinsville, IL
Rams Game
Posted Sep 17, 2014 on Hotels.comUpon entrance, the grounds, lawn-appearance was precise. The young man at the front desk was most personable and kind. Our room was perfect all around. Everyone we came in contact with were awesome.
by A verified travelerfrom Mt Vernon, Il
Terrible customer service, gave away our room
Posted Sep 14, 2014We booked this hotel almost a week in advance. We arrived late (11pm) & were told that they had "overbooked" & that they didn't have a room ready. My wife was told to give them 10-15 minutes to prepare our room. 50 minutes later we were given a key. No discounts were offered. Needless to say we will not be back.
for Getaway With Friendsby A verified traveler
great place to stay
Posted Sep 10, 2014 on Hotels.comRoom was clean, beds comfortable. Affordable. Friendly staff. Overall, great stay.


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Senate Majority Leader Harry Reid challenged House Republicans to forgo their own debate and pass the Senate's immigration bill instead, telling Speaker John A. Boehner to ignore his Republican colleagues in order to get a bill done.
In remarks kicking off Congress' stretch run to its August summer vacation, Mr. Reid said the Senate's 68-32 vote in late June to pass its immigration bill should be a beacon for the House.
"Our responsibility didn't end with that vote. Now it's our responsibility to convince our colleagues in the House they should vote with us," said Mr. Reid, Nevada Democrat.
Last month's Senate vote is increasingly looking like the high point for immigration advocates, who fear the House bill will be stricter on enforcement and less generous in its legalization of illegal immigrants — and may not even produce a bill at all, which would doom the issue yet again.
That's what happened in 2006, when the Senate passed a broad bill combining legalization and stricter enforcement while the House passed an enforcement-only bill. The two measures were so different that the two sides never bothered to go to conference to try to work out a compromise.
This year, several key differences have emerged between the House and Senate, with the most important one being different approaches to a pathway to citizenship.
In the Senate most Republicans, including even those who voted against the bill, said they believe a pathway citizenship is needed, but disagreed over what conditions to attach to it. That view is decidedly not a universal position among House Republicans, many of whom say that granting illegal immigrants citizenship amounts to an amnesty for breaking the law.
© Copyright 2015 The Washington Times, LLC. Click here for reprint permission.


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A 26-year-old West Wickham man has been jailed after a string of burglaries across Bromley borough in 2013 and 2014.
Matthew Greene, of Highbury Close, pleaded guilty to one count of burglary and asked for another nine burglaries to be taken in to consideration at Croydon Crown Court.
He was sentenced to two years and eight months in prison.
He was also given a concurrent one-month prison sentence after pleading guilty to possessing drugs.
Greene was forensically linked to a burglary committed in Layhams Road, West Wickham, on January 13 this year in which a computer and nearly £300 of vouchers given as a wedding gift were stolen.
He was arrested on January 22 and admitted to nine further burglaries committed across West Wickham and Beckenham.
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Ashes 2013-14: England cricketers Matt Prior and Stuart Broad rescue man preparing to jump from Sydney bridge
The players involved in dramatic late night incident at Darling Harbour
James Orr
James Orr is a Digital Sports Reporter for The Independent.
Wednesday 08 January 2014
England cricketers Matt Prior and Stuart Broad were involved in a late night rescue of saving a man preparing to jump from a bridge close to the team's hotel in Sydney.
"We just did what anybody would do in that situation," Prior told the Telegraph. "We were trying to help a bloke who was struggling and in a bad way. I look back and I'm just glad we left the bar when we did and we were there for him."
The 31-year-old wicketkeeper helped to pull the man, who is from Cheltenham, away from the edge before he and Broad spoke to him for almost an hour before police arrived at the scene. The players were returning from a Barmy Army England supporters event nearby.
Terry Minish, England's security officer confirmed: "Walking back to the hotel we spotted a young man on the edge of the bridge about to jump.
"He was saying he just wanted to drown. Matt helped to pull him down off the edge of the bridge and sat with him until the police arrived. It all happened very quickly and we acted on impulse. It is what you do in these situations."
New South Wales police declined to comment.
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text:
New looks of the Nike Zoom Kobe IV's flexible silhouette keep impressing sneaker fans. We've seen the "Four Rings" quickstrike model that used linear gradient approach and a somewhat milder gradient approach in a concord model, and now we have a model that is full of interesting details like snakeskin material at the toe and heel. This model, in reference to the skin of its inspiration, has been deemed the "Balck Mamba," as the dominant color is obviously black in the upper. The sole features a speckled design that is peppered with flecks of yellow, which also outlines the painted swoosh atop of the flywire in the midfoot. Yet again, the Zoom Kobe IV proves to be a versatile model in terms of both materials and styling. This model is now available at schuh-you
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Linwood Wine & Liquor Company | USD 27.99 $20.99 750ml |
Brick House Chardonnay Cascadia 2006
Similar Wines
Brick House Vineyards:
Once you have faced the challenge of finding a site for a new vineyard, you never look at a hillside in the same way again. Every slope carries a certain signature. Some have particular allure. You instinctively gauge pitch and elevation. You automatically assess exposure to the wind and sun. Every hillside holds a unique promise. And when you find one where everything feels just right, the ... Read more
Once you have faced the challenge of finding a site for a new vineyard, you never look at a hillside in the same way again. Every slope carries a certain signature. Some have particular allure. You instinctively gauge pitch and elevation. You automatically assess exposure to the wind and sun. Every hillside holds a unique promise. And when you find one where everything feels just right, the thrill is unforgettable. There are hills ...and then there are hills that have it all. Surrounded by the fruit and hazelnut orchards above the Chehalem Valley, the rolling hills at Brick House compose just such a place. A New World site dedicated to Old World wisdom, and a way of growing grapes proven over a thousand years or more : Plant them in shallow soils on a hillside and give them the morning sun, Don't plow too much. Don't hoe too little. Let them struggle. And don't ever forget that the world's finest fertilizer is the footprint of a winegrower... in the mud of March and the dust of September. At Brick House, "organically grown" is more than just a phrase on the labels of our wines. It commits us to the old ways. From our first planting in May of 1990 until today, we have relied on basics. All our fruit is estate grown. All of it is certified organic. Elemental sprays like sulfur combat disease. Fundamental farming controls weeds and shapes the hillsides beneath our vines. There are about 36,000 of them now ; a living army rooted around the old brick house on Ribbon Ridge. Pinot noir commands the lion's share of the farm: 19 acres of Pinot in all. Three low yielding clones whose ancestors hail from the vineyards of Morey St. Denis in Burgundy are planted to the east of the house and winery. Oregon's bread and butter Pinot clone, Pommard, constitutes our first planting -- ten acres along the vineyard's southern fence. Then there is the Chardonnay; clones from the Dijon viticultural station were gathered from cuttings taken near Mersault in Burgundy. A mere three acres of Dijon Chardonnay are currently in production at Brick House. One more is on the way. And finally, the Gamay noir; the standard bearer of Beaujolais, the black sheep of Burgundy. We've always loved its brilliant fruitiness and acidity. Reduce the yields, and on our soils these vines produce a rich dark wine. All our wines are produced and bottled by hand on our 40 acre farm. We count on indigenous yeast fermentations. Rarely do we fine and never do we filter Brick House wines. When the vintage... or a part of it... merit special designation, we bottle the Cuvee du Tonnelier (or the Barrelmaker's Batch) as the finest expression of our estate's unique climate and terrain. Read less
Do you love Brick House Vineyards? Follow them to show your support. Why?
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"Cookie Dough" Greek Yogurt
This wasn't amazing, but it cured a craving and was really filling. Submitted by ROCKETQUEEN467
Applesauce muffins
Can also be baked as bread with or without the raisins or nuts. Can use .25 less butter and and an equal amount of applesauce.Submitted by ONTLINDA
Chocolate Chip Cookie Fake-Outs
Sugar Free, Flour Free, Chocolate Chip Cookies!Submitted by MUDDYMELISSA


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Prepare yourselves, fans of ELLE...tonight's CW Upfront (where advertisers are shown a sneak peek of the new TV season) will feature an exclusive viewing of none other than our own reality show, STYLISTA. Behold the insanely major Anne Slowey, conveying endless style, power, and maybe just the tiniest bit of intimidation to the aspiring ELLE staffers...heading to the presentation now, stay tuned for full details tomorrow...
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Publications (450)1900.97 Total impact
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ABSTRACT: Systematic review and meta-analysis were performed to evaluate the safety and efficacy of anticoagulation for the treatment of portal vein thrombosis (PVT) in cirrhotic patients. The PubMed, EMBASE, Cochrane Library, and ScienceDirect databases were searched. The rates of bleeding complications and portal vein recanalization in patients who received anticoagulant therapy were pooled. The odds ratio (OR) with 95% confidence interval (CI) was calculated to express the difference in the rate of portal vein recanalization between anticoagulation and non-anticoagulation groups. All meta-analyses were conducted by using a random-effects model. Sixteen of 960 initially identified papers were included. Two studies reported a low incidence of major anticoagulation-related complications (4% [2/55] and 3% [1/33]), but no lethal complications occurred. The rate of anticoagulation-related bleeding ranged from 0% to 18% with a pooled rate of 3.3% (95% CI=1.1%-6.7%). The heterogeneity was not significant in the meta-analysis. The total rate of portal vein recanalization ranged from 37% to 93% with a pooled rate of 66.6% (95% CI=54.7%-77.6%). The rate of complete portal vein recanalization ranged from 0% to 75% with a pooled rate of 41.5% (95% CI=29.2%-54.5%). However, the heterogeneity was significant in the 2 meta-analyses. The rate of complete portal vein recanalization was significantly higher in anticoagulation group than in non-anticoagulation group (OR=4.16, 95% CI=1.88-9.20, P=0.0004). The heterogeneity was not significant in the meta-analysis. Anticoagulation could achieve a relatively high rate of portal vein recanalization in cirrhotic patients with PVT. Given that only a small number of non-randomized comparative studies are reported, randomized controlled trials are warranted to confirm the risk-to-benefit of anticoagulation in such patients, especially anticoagulation-related bleeding. Copyright © 2014 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.European Journal of Internal Medicine 01/2015; · 2.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Until now, no data on the routine screening for thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis (PVT) have been reported. A total of 141 nonmalignant and noncirrhotic patients with PVT who underwent screening tests for thrombotic risk factors between September 2009 and August 2012 were included in this study. The JAK2 V617F mutation was found in 35 of the 141 patients tested. Neither the JAK2 exon 12 mutation nor the MPL W515 L/K mutation was found in any of the 50 patients tested. Overt myeloproliferative neoplasms (MPNs) were diagnosed in 13 patients (polycythemia vera, n=1; essential thrombocythemia, n=9; idiopathic myelofibrosis, n=3). Latent MPNs were considered in 23 patients with the JAK2 V617F mutation but without any significant abnormalities, as determined through regular blood tests. Anticardiolipin IgG antibodies were positive in none of the 136 patients tested. Paroxysmal nocturnal hemoglobinuria was not found in any of the 141 patients tested. Neither the factor V G1691A mutation nor the factor II G20210A mutation was found in any of the 72 patients tested. The C677T mutation in 5,10-methylenetetrahydrofolate reductase (MTHFR) was found in 29 of the 38 patients tested. Hyperhomocysteinemia was detected in eight of the 39 patients tested. MPNs are an important thrombotic risk factor in Chinese patients with PVT. However, the extreme rarity of paroxysmal nocturnal hemoglobinuria, anticardiolipin IgG antibodies, and factor V G1691A and factor II G20210A mutations has precluded any support for the implementation of routine screening for these thrombotic factors in such patients. Additional case-control studies should confirm the role of the MTHFR C677T mutation and hyperhomocysteinemia in the pathogenesis of PVT.European journal of gastroenterology & hepatology. 01/2015; 27(1):77-83. - [Show abstract] [Hide abstract]
ABSTRACT: Our previous work identified thioredoxin-like protein 2 (Txl-2), a novel thioredoxin family member, as the target of the monoclonal antibody MC3 which can detect colon cancer with high sensitivity and specificity. In the present study, the function of the most abundant isoform Txl-2b in cell proliferation and apoptosis were investigated. Txl-2 overexpression correlated with increased clinical stages. Inhibition of Txl-2b suppressed cell proliferation, induced cell cycle arrest at the G1/S phase, and led to the responsiveness to the vincristine-induced apoptosis in SW620 cells. Txl-2b overexpression in LoVo cells had the opposite effect, which was dependent of Trx domain function. In vivo studies validated that Txl-2b expression promoted colon cancer tumorigenesis in nude mice. Further studies revealed that nuclear factor-κB (NF-κB) signaling was activated by Txl-2b. Inhibition of NF-κB activation partly abrogated the pro-proliferation and anti-apoptotic phenotypes mediated by Txl-2b via reduced Cyclin D1, Bcl-2, Bcl-xL and Survivin expression and increased Caspase-3 activation. Overall, our results indicate that Txl-2b expression stimulates cancer cell proliferation, accelerates the cell cycle and contributes to apoptosis resistance in colon cancer and provides a potential therapeutic target for colon cancer treatment. Copyright © 2014. Published by Elsevier Ireland Ltd.Cancer Letters 12/2014; · 5.02 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Inconsistent results of SOX2 expression have been reported in gastric cancer (GC). Here, we demonstrated that SOX2 was progressively downregulated during GC development via immunochemistry in 755 human gastric specimens. Low SOX2 levels were associated with pathological stage and clinical outcome. Multivariate analysis indicated that SOX2 protein expression served as an independent prognostic marker for GC. Gain-and loss-of function studies showed the anti-proliferative, anti-metastatic, and pro-apoptotic effects of SOX2 in GC. PTEN was selected as SOX2 targets by cDNA microarray and ChIP-DSL, further identified by luciferase assays, EMSA and ChIP-PCR. PTEN upregulation in response to SOX2-enforced expression suppressed GC malignancy via regulating Akt dephosphorylation. PTEN inhibition reversed SOX2-induced anticancer effects. Moreover, concordant positivity of SOX2 and PTEN proteins in nontumorous tissues but lost in matched GC specimens predicted a worse patient prognosis. Thus, SOX2 proved to be a new marker for evaluating GC outcome. Copyright © 2014. Published by Elsevier Ireland Ltd.Cancer Letters 12/2014; · 5.02 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: STIM1 (stromal interaction molecule 1), an endoplasmic reticulum Ca(2+) sensor that triggers the store-operated Ca(2+) entry activation, has recently been implicated in cancer progression. However, the role of STIM1 in the progression and metastasis of colorectal cancer (CRC) has not been addressed. In this study, we confirmed increased expression of STIM1 in highly invasive CRC cell lines. Enhanced expression of STIM1 promoted CRC cell metastasis in vitro and in vivo, whereas silencing of STIM1 with small interfering RNA resulted in reduced metastasis. Ectopic expression of STIM1 in CRC cells induced epithelial-to-mesenchymal transition (EMT), whereas silencing of STIM1 had the opposite effect. Furthermore, STIM1 expression was markedly higher in CRC tissues than in adjacent noncancerous tissues. STIM1 overexpression correlated with poor differentiation and higher tumor node metastasis stage. CRC patients with positive STIM1 expression had poorer prognoses than those with negative STIM1 expression. Moreover, STIM1 was found to be a direct target of miR-185, a microRNA (miRNA) that has not previously been reported to be involved in EMT, in both CRC tissues and cell lines. Taken together, these findings demonstrate for the first time that STIM1 promotes metastasis and is associated with cancer progression and poor prognosis in patients with CRC. In addition, we show that expression of STIM1 is regulated by a posttranscriptional regulatory mechanism mediated by a new EMT-related miRNA. This novel miR-185-STIM1 axis promotes CRC metastasis and may be a candidate biomarker for prognosis and a target for new therapies.Oncogene advance online publication, 22 December 2014; doi:10.1038/onc.2014.404.Oncogene 12/2014; · 8.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Loss of cell-cell adhesion is important for the development of cancer invasion and metastasis. Vinculin, a key adhesion-related protein, can affect metastasis and prognosis in several tumours. Here, we determined the biological roles of vinculin in the metastasis of colorectal cancer (CRC) and evaluated its clinical significance as a potential disease biomarker. The expression level of vinculin in CRC cell lines and tissues was measured using Real-Time PCR and western blotting. Moreover, vinculin function was analysed using Transwell assays and in vivo metastasis assays in gain- and loss-of-function experiments. Furthermore, the impact of vinculin together with membrane-bound beta-catenin on the prognosis of 228 CRC patients was investigated by immunohistochemistry. Additionally, the expression of epithelial-mesenchymal transition (EMT) indicators was verified by immunohistochemistry in CRC tissues obtained from these patients.Result: Vinculin expression was found to be significantly downregulated in highly metastatic CRC cell lines and metastatic tissues. Both in vitro and in vivo experiments showed that vinculin suppressed invasion, migration and metastasis in CRC cells and that this suppression could be attenuated by silencing beta-catenin. Moreover, the expression of vinculin and membrane-bound beta-catenin were positively correlated in CRC tissues, and lack of vinculin expression emerged as an independent prognostic factor in patients with CRC. Finally, the loss of vinculin and membrane-bound beta-catenin was associated with node metastasis, organ metastasis and expression of EMT indicators. Our results suggest that vinculin may play specific roles in the EMT and metastasis of CRC and that loss of vinculin could be used as a prognostic factor for CRC.Molecular cancer. 12/2014; 13(1):263. -
Article: The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links.
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ABSTRACT: The epithelial-mesenchymal transition (EMT) is a highly conserved cellular process that transforms epithelial cells into mesenchymal cells; EMT is involved in normal embryogenesis and tissue repair and contributes to tumor progression, including tumor metastasis, therapy resistance and disease recurrence. Cancer stem cells (CSCs) represent a fraction of undifferentiated cancer cells that exhibit stem cell-like features. They have the ability to self-renew and can seed new tumors. Thus, CSCs might represent the cellular resource that causes metastases and accounts for therapy resistance. Recent studies have highlighted a link between EMT and CSC formation. EMT is relevant to the acquisition and maintenance of stem cell-like characteristics and is sufficient to endow differentiated normal and cancer cells with stem cell properties. Moreover, CSCs often exhibit EMT properties. This reciprocal relationship between EMT and CSCs might have many implications in tumor progression. In this paper, we review current studies related to EMT and CSCs in tumor progression and therapeutic resistance, with a special focus on the common characteristics and links between these processes, and explore the importance of these links in the development of improved antitumor therapies.Current pharmaceutical design. 12/2014; - Hepatology 12/2014; · 11.19 Impact Factor
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ABSTRACT: The risk of venous thromboembolism (VTE) may be increased in patients with liver diseases. A systematic review and meta-analysis were conducted to analyze the epidemiology of VTE in such patients. All relevant studies were searched via the PubMed, EMBASE, and Cochrane Library databases. The incidence and prevalence of VTE were pooled using random-effect models. Subgroup analyses were conducted according to the type of VTE [deep vein thrombosis (DVT), pulmonary embolism (PE)], type of liver disease (liver cirrhosis alone/unclassified liver diseases or non-cirrhotics), region in which the study was performed (USA/Europe/Asia), number of total observed patients with liver diseases (>1,000/<1,000 patients), study quality (high/low), and methods for identifying the cases (ICD codes/clinical charts). Of 4,843 papers initially identified, 20 were included. The incidence of VTE varied from 0.33 to 6.32 % in 14 studies with a pooled value of 1 % (95 % confidence interval (CI) 0.7-1.3 %). The pooled incidence of DVT and PE was 0.6 % (95 % CI 0.4-0.8 %) and 0.28 % (95 % CI 0.13-0.49 %), respectively. The prevalence of VTE varied from 0.6 to 4.69 % in six studies with a pooled value of 1.0 % (95 % CI 0.7-1.2 %). The pooled prevalence of DVT and PE was 0.7 % (95 % CI 0.6-0.9 %) and 0.36 % (95 % CI 0.13-0.7 %), respectively. The heterogeneity was statistically significant in the main and subgroup meta-analyses. In conclusion, about 1 % of patients with liver diseases develop or are diagnosed with VTE during their hospitalizations. However, the epidemiological data are very heterogeneous among studies.Internal and Emergency Medicine 12/2014; · 2.41 Impact Factor -
Article: Hypoxia-Inducible lncRNA-AK058003 Promotes Gastric Cancer Metastasis by Targeting γ-Synuclein.
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ABSTRACT: Hypoxia has been implicated as a crucial microenvironmental factor that induces cancer metastasis. We previously reported that hypoxia could promote gastric cancer (GC) metastasis, but the underlying mechanisms are not clear. Long noncoding RNAs (lncRNAs) have recently emerged as important regulators of carcinogenesis that act on multiple pathways. However, whether lncRNAs are involved in hypoxia-induced GC metastasis remains unknown. In this study, we investigated the differentially expressed lncRNAs resulting from hypoxia-induced GC and normoxia conditions using microarrays and validated our results through real-time quantitative polymerase chain reaction. We found an lncRNA, AK058003, that is upregulated by hypoxia. AK058003 is frequently upregulated in GC samples and promotes GC migration and invasion in vivo and in vitro. Furthermore, AK058003 can mediate the metastasis of hypoxia-induced GC cells. Next, we identified γ-synuclein (SNCG), which is a metastasis-related gene regulated by AK058003. In addition, we found that the expression of SNCG is positively correlated with that of AK058003 in the clinical GC samples used in our study. Furthermore, we found that the SNCG gene CpG island methylation was significantly increased in GC cells depleted of AK058003. Intriguingly, SNCG expression is also increased by hypoxia, and SNCG upregulation by AK058003 mediates hypoxia-induced GC cell metastasis. These results advance our understanding of the role of lncRNA-AK058003 as a regulator of hypoxia signaling, and this newly identified hypoxia/lncRNA-AK058003/SNCG pathway may help in the development of new therapeutics. Copyright © 2014 Neoplasia Press, Inc. Published by Elsevier Inc. All rights reserved.Neoplasia (New York, N.Y.) 12/2014; 16(12):1094-106. · 5.40 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mesenchymal stem cells (MSCs) have been shown to integrate into the tumor stroma; however, the precise mechanisms of this process are still elusive. In this study, the EMT phenotype and the enhanced metastatic ability of tumor cells were observed using transwell and trans-endothelial migration assays, respectively, as well as by using electron and laser confocal microscopy. Critical genes were screened and validated using gene arrays and clinical samples, and the changes at the protein level were examined both in vitro and in vivo. Cancer cells acquired an "activated" carcinoma-associated fibroblasts (CAFs) phenotype after being in close contact with MSCs and enhancing tumor metastasis and growth in vivo. Paracrine signals also induced EMT and promoted transwell and trans-endothelial migration, the changes were dependent on β-catenin, MMP-16, snail and twist. Notably, the higher expression levels of β-catenin and MMP-16 were correlated with tumor invasion and distant organ and lymph node metastases in intestinal type gastric cancer. MSCs within the tumor niche significantly facilitated tumor growth and metastasis by paracrine cues and close physical connection. This occurred partly through snail, twist and its downstream targets, specifically β-catenin/MMP-16. This article is protected by copyright. All rights reservedJournal of Cellular Biochemistry 11/2014; · 3.37 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Uncontrolled proliferation is a key characteristic of gastric carcinogenesis and the precise mechanisms underlying the altered proliferation behaviors of GC cells have not been clearly elucidated. miRNAs has been suggested to play a crucial role in the pathogenesis and development of various cancers. In the present study, we employed an impedance-based real-time cell electronic sensing (RT-CES) system to detect the effects of ectopically expressed miRNAs on GC cell proliferation.Journal of Cancer Research and Clinical Oncology 10/2014; · 3.01 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To investigate and compare the efficacy and safety of percutaneous transhepatic biliary stenting (PTBS) using a one- or two-stage procedure and determine the predictive factors for the efficacious treatment of malignant hilar obstruction (MHO).CardioVascular and Interventional Radiology 10/2014; · 1.97 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Recent studies have reported that hyper-methylation in the promoter region of miRNAs could silence the expression of tumor suppressive miRNAs and might play significant roles in the process of tumor development. However, the potential mechanisms regarding how methylation of miRNA CpG Island could regulate cancer cell chemo-resistance have not yet been studied. Using microarray and BSP (Bisulfate Sequencing PCR) assays, we found that compared with the parent SGC7901/VCR cells, expression of miR-129-5p was restored in SGC7901/VCR gastric cancer multi-drug resistant cell line treated by de-methylation reagent (5-AZA-dC). Using gain or loss of function assays, we found the over-expressed miR-129-5p reduced the chemo-resistance of SGC7901/VCR and SGC7901/ADR cells, while down-regulation of miR-129-5p had an opposite effect. Furthermore, three members of multi-drug resistance (MDR) related ABC transporters (ABCB1, ABCC5 and ABCG1) were found to be direct targets of miR-129-5p using bioinformatics analysis and report gene assays. The present study indicated that hyper-methylation of miR-129-5p CpG island might play important roles in the development of gastric cancer chemo-resistance by targeting MDR related ABC transporters and might be used as a potential therapeutic target in preventing the chemo-resistance of gastric cancer.Oncotarget 10/2014; · 6.63 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A growing amount of evidence indicates that miRNAs are important regulators of multiple cellular processes and, when expressed aberrantly in different types of cancer such as hepatocellular carcinoma (HCC), play significant roles in tumorigenesis and progression. Aberrant expression of miR-199a-5p (also called miR-199a) was found to contribute to carcinogenesis in different types of cancer, including HCC. However, the precise molecular mechanism is not yet fully understood. The present study showed that miR-199a is frequently down-regulated in HCC tissues and cells. Importantly, lower expression of miR-199a was significantly correlated with the malignant potential and poor prognosis of HCC, and restoration of miR-199a in HCC cells led to inhibition of the cell proliferation and cell cycle in vitro and in vivo. Furthermore, Frizzled type 7 receptor (FZD7), the most important Wnt receptor involved in cancer development and progression, was identified as a functional target of miR-199a. In addition, these findings were further strengthened by results showing that expression of FZD7 was inversely correlated with miR-199a in both HCC tissues and cells and that over-expression of miR-199a could significantly down-regulate the expression of genes downstream of FZD7, including β-catenin, Jun, Cyclin D1 and Myc. In conclusion, these findings not only help us to better elucidate the molecular mechanisms of hepatocarcinogenesis from a fresh perspective but also provide a new theoretical basis to further investigate miR-199a as a potential biomarker and a promising approach for HCC treatment.PLoS ONE 10/2014; 9(10):e110074. · 3.53 Impact Factor - CardioVascular and Interventional Radiology 10/2014; · 1.97 Impact Factor
- Saudi Journal of Gastroenterology 09/2014; 20(5):265-266. · 1.22 Impact Factor
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ABSTRACT: An increasing body of evidence indicates that miRNAs have a critical role in carcinogenesis and cancer progression; however, the role of miRNAs in the tumorigenesis of adencarcinoma of gastric esophageal junction (AGEJ) remains largely unclear.BMC Cancer 08/2014; 14(1):633. · 3.32 Impact Factor -
Article: Transjugular Intrahepatic Portosystemic Shunt for Acute Variceal Bleeding: A Meta-analysis.
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ABSTRACT: Acute variceal bleeding is the most common lethal complication of liver cirrhosis. A meta-analysis was conducted to compare the outcomes of transjugular intrahepatic portosystemic shunt (TIPS) to those of medical/endoscopic therapy for acute variceal bleeding in cirrhotic patients.Journal of Clinical Gastroenterology 08/2014; · 3.19 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: AbstactBackground and AimThe gut microbiota plays a pivotal role in the intestinal diseases. Fecal microbiota transplantation (FMT) might be a rescue therapy for refractory inflammatory bowel disease. This study aimed to evaluate the safety, feasibility and efficacy of FMT through mid-gut for refractory Crohn's disease (CD).Methods We established standardized laboratory protocol and clinical work flow for FMT. Only refractory CD patients with Harvey-Bradshaw Index (HBI) score ≥ 7 were enrolled for this study. All included patients were treated with single FMT through mid-gut and assessed during follow-up.ResultsMetagenomics analysis showed a high concordance between feces sample and purified fecal microbiota from same donors. Standardized fecal microbiota preparation and clinical flow significantly simplified the practical aspects of FMT. Totally 30 patients were qualified for the present analysis. The rate of clinical improvement and remission based on clinical activity at the first month was 86.7 % (26/30) and 76.7 % (23/30) respectively, which was higher than other assessment points within 15-month follow-up. Patients' body weight increased after FMT, and the lipid profile improved as well. FMT also showed a fast and continuous significant effect in relieving the sustaining abdominal pain associated with sustaining CD.Conclusions This is a pilot study with the largest sample of patients with refractory CD underwent single FMT. The results demonstrated that FMT through mid-gut might be a safe, feasible, and efficient rescue therapy for refractory CD.Journal of Gastroenterology and Hepatology 08/2014; · 3.33 Impact Factor
Publication Stats
5k | Citations | |
1,900.97 | Total Impact Points | |
Top Journals
- Journal of Gastroenterology and Hepatology (15)
- PLoS ONE (15)
- Cancer biology & therapy (13)
- Cancer biology & therapy (12)
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Fourth Military Medical University
- • State Key Laboratory of Cancer Biology
- • Department of Gastroenterology
Xi'an, Liaoning, China -
Virginia Commonwealth University
- School of Medicine
Richmond, VA, United States
Chinese Academy of Engineering Physics
Peping, Beijing, China
State Key Laboratory of Medical Genetics of China
Ch'ang-sha-shih, Hunan, China
Xi'an Jiaotong University
- • School of Science
- • Department of Gastroenterology
Xi'an, Shaanxi Sheng, China
Logistical College of Chinese People's Armed Police Force
T'ien-ching-shih, Tianjin Shi, China
Huazhong University of Science and Technology
Wu-han-shih, Hubei, China
General Hospital of Jinan Military Region
Chi-nan-shih, Shandong Sheng, China
Southern Medical University
Shengcheng, Guangdong, China
Emory University
- Department of Internal Medicine
Atlanta, GA, United States


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Young Forever (feat. Mr. Hudson) (4:14)
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Mr. Hudson told Digital Spy about working on this song. (Source Young Forever Songfacts): "That was a quick thing. It's funny because sometimes big tracks come really easily. I'm not exaggerating, but we did it in an hour. Kanye spent about half an hour on the beats, I spent half an hour on the vocal and then we were like, 'Cool, let's send it to Jigga'. And he loved it, so it was almost too easy. If only that could happen every day!"
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Hong Kong's leader CY Leung has said the territory must choose between greater democracy and growth.
Afghan President Ashraf Ghani has unveiled his unity cabinet more than three months after he was sworn in.
Mahinda Rajapaksa lost bid for third term, ending rule that critics say had become increasingly authoritarian.
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We stayed at this hotel during xmas 2014 and was very disappointed with the whole experience. They classify themselves at being five star, at best, it would have been a two star hotel. The rooms smelled very musty and was filthy. There were old shoes in the room probably left by previous occupiers. The bathroom had mould all around the... More
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Megan Fox Lesbian Scene In Jennifer Body
Megan Fox has filmed a "really hot" lesbian love scene for her new movie. The 'Transformers' actress romps topless in bed with 'Mamma Mia' star Amanda Seyfried in a zombie film 'Jennifer's Body'. The two girls make out hardcore, rolling around in a bed. It was a really hot scene.
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We will delivery to all cities in
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tepatnya pada tangGal 6 DESMBER2014 SAYA MENANG LAGI 4D 4006saya mau berbagi cerita kepada teman teman, dulunya pekerjaan saya sangat jelek tetapi mau diapa karna kami dari keluarga miskin yang tidak punya apa apa, tetapi sekarang saya sudah bisa membahagiakan k2 orang tuaku dan saya juga sudah meningGalkan pekerjaan tersebut itu semua berkat BANTUAN EYANG PESSA, SEMBAH SUJUD KAMI SEKELUARGA MENGUCAPKAN BANYAK TERIMA KASIH SETINGGI TINGGINYA KEPADA EYANG PESSA ATAS BANTUAN ANGKA GOIB/JITU EYANG SAYA BISA KELUAR DARI SEGALA MASALAH TERUTAMA PEKERJAAN SAYA. BUAT TEMAN TEMAN INI ADALAH KENYATAAN BUKAN REKAYASA, BAGI TEMAN2 YANG HOBI MEMASANG ANGKA TOGEL SAYA SARANKAN HUBUNGI EYANG PESSA DI-082 313 367 336,DIJAMIN100%PASTI TEMBUS. KAMI SEKELUARGA SUDAH MEMBUKTIKAN DENGA 3X KEMENANGAN YANG DI BERIKAN EYANG PESSA ..........TERIMA KASIH.................. SEMOGA ANDA BISA SUKSES SEPERTI SAYA
Horay, horay! This is the initial step of a long process of justic. Trust the system that will give a fair go as a lot of personal opion are out there in the public and may influence the jury's decision. Keep the fingers crossed and good luck.
For much of the last half-century, changing China through economic reform seemed to make far better sense than transforming the country through political revolution. Xi Jinping is trying to flip that on its head.
New legal developments that help environmental non-profits sue polluters now offer some hope for those fighting the degradation of China's ecosystem.
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Updated 09/20/2013
An old-fashioned sushi restaurant with a few tables on tatami mats and a long bar counter with stools, the rustic Aoki has a cheerful staff and reasonable prices. It's also within easy walking distance of Tsuwano Station. Try the jyo-nigiri (deluxe sushi set); it will likely include a slice or two of tasty, chewy koi, or local carp. That and a frosty mug of beer set you back only ¥1,900. The restaurant stays open until 10 pm.
Restaurant Details:
Updated 09/20/2013


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Seabrook, NH Office Space for Rent, Warehouses, and Retail Locations
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Commercial real estate agents (8) Commercial real estate companies (8) Tenant leasing requirements (0) Lease and sale comps (0)Nearby Commercial Real Estate Listings:
Amesbury, MA (21)Groveland, MA (13)Merrimac, MA (3)Newbury, MA (1)Newburyport, MA (13)Salisbury, MA (8)East Kingston, NH (1)Exeter, NH (61)Greenland, NH (9)Hampton, NH (82)Hampton Falls, NH (9)Kingston, NH (13)North Hampton, NH (42)Rye, NH (7)Stratham, NH (12)Showing 1 - 20 of 36 buildings with 21 total listings
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Rofo researches and displays commercial real estate listings from top brokerage firms and landlords in Seabrook, NH making it easier to find available commercial space and compare current asking rental rates. In Seabrook, NH there are currently 6 office spaces for lease, 5 warehouse spaces for rent, and 8 retail spaces with 8 real estate professionals to help you find the right space for you. Sizes range from 3,000 square feet up to 6,500 square feet. Filter your search below and get free advice from recommended brokers in Seabrook, NH.


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Who's better, Federer or Roddick???
What do u think? Fed or Rod!
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What to do if your crush catches you staring at him
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We would like to give you a tour. Just click the link to the right to get started.
1000 Medical Center BoulevardLawrenceville, GA 30046678-312-1000
As 'national ambassador' for March of Dimes this year, Elijah Jackson and his family will help raise awareness of issue
But study found overall rate was under 4 percent
Researchers found differences and evidence of damage in areas of brain related to recall
Come join us for a fun fitness class made bariatric friendly, with numerous modifications that adapt to all fitness levels where you will focus on endurance, flexibility and strength. So come 'get your fit on' with Fitness in Motion! Sign-ups through the website are appreciated, but not required to participate in this group.
This group is free for all CWM patients.
The Inpatient Medical Group provides care to the hospitalized patients of GMC and GMC–Duluth. The service is available 24-hours a day, seven days a week. The group accepts referrals from primary care practices, provides medical consults as requested and covers patients in need of admission from the Emergency Department who do not have a primary care physician. Our inpatient physicians, or "hospitalists," have completed training in internal medicine and many have additional subspecialty training. GMC's hospitalists allow primary care physicians the ability to focus on outpatient or office-based care while referring hospitalized patients' care to a team of hospitalists.
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Home Office policy on life prisoners unlawful
LAW REPORT 4 October 1995
The Home Secretary's policy of not referring discretionary life prisoners' cases to the parole board, save for some compelling reasons, until after the expiration of the tariff or penal periods of their sentences was unreasonable and unlawful.
Mr Justice Dyson declared that the Home Secretary should have referred the applicants' cases to the parole board at such times as would have ensured so far as practicable that their cases were heard by the board immediately on the expiration of the tariff or penal part of their sentences.
In 1976 the five applicants, members of the provisional IRA, were convicted of offences of attempted murder and conspiracy to cause explosions and were sentenced to terms of life imprisonment. Each was notified in 1992 that his tariff period, set for the purposes of retribution and deterrence, was 20 years. On expiry of the tariff period, the parole board would decide whether a further period should be served if there was a risk to the public.
The Home Secretary refused the applicants' solicitors request to refer the cases to the parole board so that they would be heard immediately on the expiration of the tariff periods in July 1995. When the cases were referred to the board the chairman refused applications for expedition of the hearings and hearings were fixed for December 1995. The applicants applied for judicial review of those decisions.
Edward Fitzgerald QC (B.M. Birnberg & Co) for the applicants; Kenneth Parker QC (Treasury Solicitor) for the Home Secretary.
Mr Justice Dyson said that section 34 of the Criminal Justice Act 1991 governed the release of discretionary life prisoners. The European Court of Human Rights had held that it was the right of prisoners to be released if there was no longer a risk to the public, and prisoners were entitled under article 5(4) of the European Convention on Human Rights to a judicial determination of the question of risk.
The Home Secretary accepted that he had a discretion to refer cases to the board before the expiration of the tariff period but the policy under section 34 was not to refer cases until after the expiration of the tariff period unless there was a compelling reason, such as the case of a terminally ill prisoner, and contended that a hearing 23 weeks later satisfied the requirements of domestic and European Convention law.
That policy was unreasonable and therefore unlawful. In the cases of prisoners who were no longer dangerous and who ought to be released on the expiry of their tariff periods, the policy produced results which were manifestly unjust. The implementation of the policy meant that prisoners who were judged no longer dangerous were required to serve sentences approximately six months longer than they should.
The policy flouted the principles of common law and the European Convention. The common law required that a discretionary life prisoner be released after completion of the tariff period unless he continued to be dangerous. Article 5(4) required a speedy review of the lawfulness of the detention.
Where it was clear that the statutory provision which created the exercise of executive discretion was passed in order to bring domestic law in line with the convention, it would be perverse to hold that, when considering the lawfulness of the exercise of the discretion, the court must ignore the convention.
Nor could the policy be saved by invoking considerations of convenience and pragmatism where what was at stake was the liberty of the subject. It could not be stated too strongly that, once the prisoner had served the tariff period, he had paid the penalty imposed by the court to meet the needs of retribution and deterrence; detention thereafter could not be justified unless the prisoner continued to be dangerous. The ECHR had held that a period of eight weeks delay before a hearing was difficult to reconcile with the notion of "speedily".
However, the decision to refuse expedition of the hearings could not be impugned as irrational or unlawful.
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The famous Aaron Burr "Got Milk?" ad from 1993 was directed by Michael Bay.
Looking to spice up your holiday conversations? Here are a few clips that should help you impress your dinner mates this Thanksgiving. Want to impress your family and friends?
Food isn't the only reason I'm looking forward to Thanksgiving this year.
NOVA: What Are Dreams? airs on PBS stations in the US tonight, Tuesday, November 24. This is a terrific documentary on dreams, packed with specifics on the science of sleep.
Every year, the Susan G. Komen foundation organizes 15 three-day walks in cities across the country to raise awareness about and funds to help fight breast cancer.
If you enjoy placing your furry friends in tubes the living room, then you should consider investing some money in the creation of this gerbil vest featured on Neatorama.
Serving traditional holiday foods can be a great way to bond with family members and create lasting memories. It can also become boring after so many years.
It's an all-new 5-day trivia hunt, with an all-new set of puzzles, prizes, and now, a major sponsor! Co-puzzle Master Josh Halbur and I are thrilled to announce that How Did You Know?
While the NFL gets most of the press, pro basketball and hockey are also in full swing this time of year.
Americans consume around 46 million Turkeys over the Thanksgiving holiday.
I can't wait for Thanksgiving.
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The Food and Drug Administration has issued a number of dangerous food recalls in the last few years. But there was a time when food didn't just attack us after we ingested it.
Objectified airs on PBS stations in the US on Tuesday, November 24, as part of the Independent Lens series.
Some of you might recall my post, The 13 Types of Friends on Facebook, and, more specifically, category C, The Groupie, which I described as the friend who has joined more groups than Marcia Brady did
Isn't this remarkable?


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WORCESTER -- Eric Gauthier, left, of East Brookfield and Adam Williamson, right, of Spencer hang LED Christmas lights on trees on Worcester Common Friday. Both work for Christmas Decor by A. Arsenault & Sons Inc. in Spencer.
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World Ringtones - African
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World Ringtones African Ringtones brings 45 free ringtones and sounds to your Android™ device. Personalize the default …
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Wincraft, Inc. NBA Flag
Officially licensed flag. Designed to hang vertically from an outdoor pole or inside as wall decor. Durable polyester flag. Machine washable. Poles and hardware available separately.
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Wincraft, Inc. NBA Flag
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Wincraft offers a wide variety of fan products to make every day feel like game day. Show your team spirit with original products like their Keg-A-Cue, snack helmet, clocks and lamps, team pendents and flags, and more!Wincraft, Inc. NBA Flag
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NBA Flag is also sometimes listed under the following manufacturer numbers: 12872412, 15106810, 1623010, 1625010, 17293012, 1972010, 1982010, 3475010, 3586011, 3727010, 4636010, 4684013, 63085312, 88737012, 88754011


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A bit of fun, to see if your main character is really original, or powered by your id (or even your ego)... http://www.springhole.net/quizzes/marysue.htm
I've taken that one before, it's a really good test. Scored an impressive 6 for a character I was really worried about.
According to that, my main character "could probably take a little spicing up", so I've made him a vampire and given him four foreign languages. And naturally purple hair.
Mine too (I got 6, like thatollie). I made her an exiled amnesiac princess called Barbie-Wonderful who can fly.
My character is already a blind girl who can shoot (because she has psychic powers that make it so), does she really need any more spice.
I'm quite skeptical of this test. When ever you put anything that makes the character interesting in part 1 it goes up. A lot of the things in part 5 (the de-suifiers) are pretty common in a lot of characters and do not make them unique. Such as: 1. Use character's weaknesses as a plot device 10. Debilitating phobia that does not mysteriously disappear at a crucial moment. 12.Bad past with parents (at least with troubled characters) 14. Overcomes tough problem that seemed hopeless, difficult and/or took a long time. 15. Character doubts they do the right thing (even though they usually did the right thing) 23. Vampire part 22. Act in strange ways It also doesn't take into account the uniqueness of the combinations of traits the can make characters interesting or not.
My protagonist is totally powered by my id, but only managed a 3 - OTOH I'm not writing anime fanfic, which this test seems heavily weighted towards
I'm worried. I applied the test for all four of my main characters (in parallel) and got a 5. Apparently I need to spice them up.
Hmmm. Don;t know about this test. I did my best with my main character and she scored a 17, which is borderline for needing a bit of spicing up. Sure, this little test gave me a few moments to think about my main character, but it really didn't feel that satisfying.
I also got six. Princess Barbie-Wonderful sounds like she'd be a perfect match for my main character, Hex. Prince Absolutely Super-Sexy.
I'm pretty sure my little guy (or really, all three of them together) only scored so low because (1) they are kids, so all the sex questions don't apply, and (2) at least one of them is modeled after my son, but not me, so those questions don't technically apply either.
I scored 13 for Space Captain Smith. I think I would have scored much lower had I not liked his outfit.
I did this for my main character and got a score of -1, dunno if I should be sad about that or not, hmmm...
Scored an unusually low -11. But my protagonist is very firmly grounded and realistic. More of a witness to the fitness than the heroic instructor, if you know what I mean.