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FREE cancellation on most rooms!
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Health & Wellness Center Energetikas Kursiu takas 1, LT-00317 Šventoji, Lithuania | ||
Score from 145 reviews:
Health Centre Energetikas is situated a few steps from the Baltic Sea and its sandy beaches in the resort town of Šventoji, 10 km from Palanga.
" Nothing, the worst service ever.We were suppose to stay second night, but we did refuse, because there were no beds for baby girls, no condition, the rooms were dirty, breakfast worst than in hospital, ... " |
from $36 Average price per night |
Medical SPA Eglės sanatorija Druskininkai Eglės g. 1, LT-66251 Druskininkai, Lithuania | ||
Score from 32 reviews:
Review score
There are 2 people looking at this resort.
Offering an indoor pool and a spa and wellness centre, Medical SPA Eglės sanatorija is located in Druskininkai. Free WiFi access is available throughout this resort.
from $46 Average price per night |
Nakcižibis Lavyso km. Marcinkoniu sen. Varenos raj., LT-65374 lavysas, Lithuania | ||
Score from 12 reviews:
Nakcižibis is located in the quiet village of Lavysas, in the beautiful surroundings of trees and the Lavysas Lake.
from $76 Average price per night |
Rimuošės Dvaras - RD Motel Šiaulių plento 4a, , LT-82049 Šniūraičiai, Lithuania | ||
Score from 172 reviews:
Very good
Rimuošės Dvaras - RD Motel is a leisure complex with motel-type rooms, located only 100 metres to the Šiauliai-Radviliškis highway. It features a restaurant and a 20-meter indoor swimming pool.
" Great to relax with spa, sauna and pool facilities. Lovely restaurant, and good breakfast (included) Good location given we had a car that we wanted to park safely outside the city. " |
from $36 Average price per night |
Harmony Park Vazgaikiemo k., Balbieriškio seniūnija, Prienų rajonas, LT-59257 Prienai, Lithuania | ||
Score from 91 reviews:
There are 2 people looking at this resort.
Offering free entry to the baths area, Harmony Park is situated in a peaceful and quiet area of Vazgaikiemis. It features spacious, air-conditioned rooms with elegant interior design and a minibar.
" Everything was perfect: room (we took Liux room), breakfast, dinner, pool, SPA, service. We had excellend weekend. " |
from $147 Average price per night |
Dubingiai Giraičių kaimas 8, Dubingiai, Molėtų r. sav., LT-33260 Giraičiai , Lithuania | ||
Score from 41 reviews:
Very good
Situated in a woodland area 100 metres from the Lake Asveja, Dubingiai boasts a private beach.
from $34 Average price per night |
Skaidrioji g. 12, LT-96155 Gargždai, Lithuania


text:
Hey everyone! Our Lady of Weight Loss and I are invited to our neighbors' tonight to celebrate the Jewish New Year. Needless to say, Our Lady volunteered me to bring dessert. So, I'm bringing my famous Oranges in Fig Sauce. It's easy to make, delicious and so pretty on the platter! Heads will spin! Tune in for secret ingredient!!!FYI … When shooting this video, I was so into the making of the Oranges in Fig Sauce that I forgot to put on real pants. I'm wearing my 'fortune cookie pj bottoms!' Just in case you were wondering what kind of fashion statement I was making; I wasn't! I just wanted the sauce. Hope you will join with us in celebration and dessert!Oranges in To Die For Fig Sauce (I'm salivating just thinking about it).Naval Oranges1/2 cup Fig Balsamic Vinegar (the most expensive you can find)1/2 cup Sugar (organic is always a good idea)Follow directions on video! Enjoy!More Food News and Recipes:Stuck on ChocolateEat. Have Sex. Loss Weight.Go Healthy: Cooking TipsSpread the word (NOT the icing!),Janice____________________________________Follow Janice on Twitter and/or Facebook! Required Reading:Our Lady of Weight Loss: Miraculous and Motivational Musings from the Patron Saint of Permanent Fat Removal an OPRAH BOOK CLUB pick: Summer 2009 – Buy NOW!Join the Our Lady of Weight Loss's Kick in the Tush Club: Beliefnet Chapter.Write Janice Taylor, Weight Loss Coach, Certified Hypnotist, Author and 50-pound big-time-loser for an introductory one-on-one coaching session. Visit Our Lady of Weight Loss.
click here to see all of our uplifting newsletters» Search This Blog
About Our Lady Of Weightloss
"Janice Taylor is a 'kooky genius'"
~ O, The Oprah MagazineJanice Taylor is a Weight Loss Coach and Certified Hypnotist, author, artist and motivational speaker. She is the author of Our Lady of Weight Loss: Miraculous and Motivational Musings from the Patron Saint of Permanent Fat Removal and All Is Forgiven, Move On: Our Lady of Weight Loss's 101 Fat-Burning Steps on Your Journey to Sveltesville (publication date May 15, 2008). Janice is also the creator of the popular e-newsletter Kick in the Tush Club and a 50-pound big-time-loser.
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Friday, August 12, 2011
- Deficit Super Committee Finalized with Democratic Picks
- Obama Urges Public to Pressure Lawmakers over Economy
- Texas Gov. Rick Perry to Enter GOP Race
- GOP Presidential Hopefuls Square Off in Iowa Debate
- Republican Front-Runner Mitt Romney: "Corporations Are People"
- Top 500 U.S. Firms Increase Holdings 59% Since 2008
- Pennsylvania Judge Sentenced to 28 Years for "Kids-for-Cash" Scheme
- Report: 773 Pakistani Civilians Killed in U.S. Drone Strikes
- Libyan Rebels Advance in Brega; Tripoli Residents Protest NATO Bombing
- Syrian Forces Attack Civilians; Hama Residents Detail Crackdown
- British PM Threatens to Restrict Social Media in Riot's Aftermath
- U.S. Boosts Horn of Africa Famine Aid by $17 Million
- Israel Approves 1,600 New Settlement Homes in Occupied East Jerusalem
- Industry-Linked Panel Backs Controversial Natural Gas Fracking
AIDS-Afflicted U.S. Citizen Urges Obama Admin to Reverse Deportation of Australian Husband
The Obama administration's enforcement of the Defense of Marriage Act is threatening to tear apart the seven-year marriage of a binational gay couple in San Francisco. Bradford Wells, a U.S. citizen, and Anthony John Makk, an Australian national, have lived together for 19 years and were among the first same-sex couples to legally marry in Massachusetts. Anthony is also the primary caretaker for his husband, who has HIV/AIDS. Makk is facing deportation this month after the Obama administration denied them the same immigration benefits routinely given to opposite-sex couples. The decision is based on the so-called Defense of Marriage Act, the 1996 law known as DOMA, which denies federal benefits to same-sex couples. The Obama administration has said it would no longer defend DOMA in the courts, but the law still remains in effect. Bradford Wells and Anthony John Makk join us from San Francisco. We also speak to Rachel Tiven, executive director of Immigration Equality. [includes rush transcript]
Bipartisan "Super Committee" Turns to Cutting Deficit with "Extraordinary" Powers
The bipartisan "super committee" tasked with finding a way out of the U.S. debt crisis has been established, but what can we expect? On Thursday, House Democratic leader Nancy Pelosi named the final three members to the 12-person panel, split evenly between Democrats and Republicans. They will have until November 3 to recommend a plan to cut $1.5 trillion from the deficit over 10 years. We speak with Robert Borosage, founder and president of the Institute for America's Future and co-director of its sister organization, the Campaign for America's Future. Borosage says the committee's authority is unique in Congress, with "powers [that] are quite extraordinary." [includes rush transcript]
As Texas Gov. Rick Perry Enters GOP Race, New Exposé Reveals His Close Ties to Radical Evangelicals
Republican Gov. Rick Perry of Texas is expected to announce his entry into the 2012 presidential race. Perry will make the announcement Saturday at a conference in South Carolina organized by Erick Erickson's RedState.com. Early backers of Perry's presidential run have heralded him as being behind the so-called Texas economic miracle. However, many have questioned Perry's economic claims in Texas. Questions have also arisen over Perry's close ties to the radical wing of the Christian evangelical movement. Last Saturday, Perry helped organize and spoke at a controversial seven-hour Christian prayer rally in Houston titled "The Response: A Call to Prayer for a Nation in Crisis." While the prayer session drew 30,000 participants and received national press, little attention was paid to the Christian evangelicals Perry worked with to organize the event. The Texas Observer has just published an explosive article titled "Rick Perry's Army of God." It exposes how a group of radical Christians and self-proclaimed prophets from a little-known movement known as New Apostolic Reformation have been quietly pushing for Perry's presidential bid. We speak with the Texas Observer's Forrest Wilder. [includes rush transcript]
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Coun. Doug Ford says the mayor's personal contact list is being used by the Karen Stintz campaign team to drum up donations. Police and city officials are looking into the matter.
Video: Female struck & killed by car in Scarborough
Const. Clint Stibbe confirmed that a woman died after she was struck by a car on Birchmount Road in Scarborough on Wednesday morning. The intersection was closed but has since reopened.


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Fish and Wildlife Administrator - Deputy Assistant Director
Knowledge of the Federal legislative and budget processes. You too can make a difference in our world....Interior, US Fish and Wildlife Service Falls Church, VA . posted Jan 30, 2015
For consideration at the GS-13 level, you need to have at least one year of full-time experience that is equivalent to attorney work at the grade 12 in the...Environmental Protection Agency Washington, DC . posted Jan 29, 2015
You will also collaborate with the Commission as they advocate for the current and future needs of seniors and serve as the liaison between the Commission on...City of Alexandria, VA Alexandria, VA . posted Jan 30, 2015
Director, Legislative Affairs
This position reports directly to the Vice President, Legislative Affairs, and provides primary legislative support to the International Affairs Division....AIA Arlington, VA . posted Jan 30, 2015
Director – National Small Business (NSB) Risk Management and Policies
San Francisco, California Police Code Article 49, Sections 4901-4920; Director – National Small Business (NSB) Risk Management and Policies - 773262 Capital One...Capital One McLean, VA . posted Jan 18, 2015
Vice President of Legislative Affairs
Legislative goals, including federal policy initiatives and support for company programs. Provide the Senior Vice President and sector leadership with timely...BAE Systems Arlington, VA . posted Jan 27, 2015
Supporting the VP, Legislative Affairs (House) in managing the shaping of legislation regarding Department of Defense, Coast Guard, and other federal agencies,...Huntington Ingalls Industries Inc. Washington, DC . posted Jan 29, 2015
Applicants for attorney positions must possess a professional law degree (LL.B or J.D.). Will be required to analyze legal authority for funding programs based...Headquarters, NASA Washington, DC . posted Jan 13, 2015
Business and Technology Sourcing Associate
The position is open to relos and transactional attorneys but the firm will give preferential consideration to candidates with prior outsourcing, technology and...MLA Global Washington, DC . posted Jan 29, 2015
Our client is looking for a talented junior attorney with excellent academic grades, experience gained at a top law firm....Haven Legal Recruitment Washington, DC . posted Jan 28, 2015
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Have A Blessed Sunday T.E. loving your music here at Bonnie's Cafe'…BFF… Bonnie
Have a great SaturdayT.E. ...We're playing your awesome music here at Bonnie's Cafe'..Coffee's ready and we saved you your favourite Booth by the fireplace .. BFF..love... Bonnie
if you or anyone you know needs more exposure, check out www.goo.gl/0AwNNs ad tell them Dabber sent you! I help them with cool DJ's and producers
Hi Te :) Back this morning to play some of my RN favs :) M.L.F.L Emily
Hi T.E. my awesome friend ...Starting my Monday out playing your great music here at Bonniie's Cafe'and having coffee and visiting with all out friends...We look forward to your visits and welcome you every day... BFF...love... Bonnie


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discoV.21 No.51 | timewasterHoliday greetingsBoring and bizarreChristmas is best tackled with a sense of humor. Otherwise it's a great occasion for a nervous breakdown or a stroke. I hope everyone will heed William Shatner's holiday advice. This Mennonite has a boring Christmas message (with hypnotic music) about saving the world without spending too much on postage. Here are the Christmas greeting cards you wish you'd received, and the family photos you're happy are not yours. Rest assured your office Christmas party went better than the Bluth's party. Listen to some Neil Hamburger (w/ Canned Hamm) jokes! Enjoy the full Christmas With the Chipmunks album from 1961, or just forget the whole thing with FEAR. V.21 No.25 | 6/21/2012 Group HugDance in Bowie's Pants TONIGHT"In the '70s, rock and roll flew an intergalactic cruise ship to the planet Glitter and mined its three moons—Pleasure, Androgyny and Polyester. Its captains were the likes of Ziggy Stardust, The Sweet, Slade, Queen, Elton John, the New York Dolls, T. Rex and the cast of The Rocky Horror Picture Show." —Jessica Cassyle Carr, music editor This very eve, we seek to glam rock with you at our annual pre-Pride dance party. The New Mexico titleholders will perform, and DJs Cassyle, Tahnee and Nicolatron will spin you to the moon. Plus, there will be sparkly cupcakes from Rebel Donut, and free snaps from Photobooth Rentals of New Mexico. Silver unitards encouraged. V.21 No.26 | 6/28/2012 Group HugBallroom BlitzHot damn, it's bound to be sweaty this week as Albuquerque Pride 2012 kicks off. Temperatures could soar over 100 degrees on Saturday when the crowning festivities take over the city. The better to glue your glitter with, my pretty! From the bravery of Stonewall rioters to the chief pro-Prop 8 witness reversing his stance on Friday, there are countless shining moments of LGBTQ history to celebrate. With that in mind, the Alibi and Albuquerque Pride proudly extend a sparkle-laden Group Hug to start the revelry off right. Exclamatory particulars of the Pre-Pride Glam Dance Party: Wednesday, June 27 (Tomorrow!) 9:30 p.m. 18+ welcome, but you must be 21 to drink. (Don't forget your ID!) Lotus nightclub, 211 Gold SW. A mere $5 gets you in the door. DJs Tahnee, Nicolatron and Cassyle will spin disco / electro / glam hits to whirl your Disco Queen into a frenzy. Rebel Donuts' sugar wizardry will have her licking glitter frosting off your face. Hotpants, shiny jumpsuits, towering collars, feathered hair, space oddities—all mightily encouraged. V.21 No.25 | 6/21/2012 Aural FixationGlamorousYou're invited to the Alibi's Pre-Pride Glam Dance PartyV.21 No.21 | 5/24/2012 In MemoriamR.I.P., Disco QueenIn more sad music news, Donna Summers died today at age 63 after battling cancer. V.20 No.23 | 6/9/2011 Group HugHear my dulcet voice describing tonight's Alibi Glam Dance PartyIn preparation for tonight's big-ass gay pride glam dance party at Casa Esencia, Mike Mackenzie had me on his morning radio show to talk a little bit about it. (Kudos to Mike and co. for supporting Pride Week and Albuquerque's gay community on-air at KKOB 93.3). I've been on the radio a handful of times, and this was by far the most fun I've had doing it. Take a listen. MusicParty PreviewMusical selections from tonight's Pre-Pride Glam Dance PartyTonight the Alibi's Group Hug and Albuquerque Pride are hosting the Pre-Pride Glam Dance Party at the beautiful Casa Esencia (800 Rio Grande NW) in Old Town. This will be an evening filled with tiny bubbles, delicious canapés, shiny tunage and general fabulousness. The entertainment is as follows: La Juala, fronted by sultry international torch singer Georgina, will perform live at the beginning of the evening, and will be followed by DJs Cassyle (c'est moi), Mello, Tahnee and Nicolatron. Naturally, there will be a drag show as well. To get a feel for the general aesthetic, below are some classic glam rock track that we're likely to play. For good measure, we'll be spinning disco and electro tracks, too.) You can also click here for a playlist full of early glam. Enjoy! P.S. You can RSVP to he party here. V.20 No.2 | 1/13/2011 MusicYelle MondayHere's a link to a free download of "Safari Disco Club"—the title track from Yelle's second album. The full installment of French dance pop will be released in the U.S. in late March. This isn't proving to be the best music for a Monday at work, but I can imagine it being très bien after dark. | Today's EventsA Path Appears at KiMo TheatreFrom the creators of Half the Sky, this film reveals the incredible adversity faced by millions of women and girls every day. Runes 101 at Abitha's ApothecaryAcoustic Essence at Embers SteakhouseMore Recommented Events ››
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Iran vote delayed to avoid influencing Israel's election, senator says
Peres on Netanyahu speech: When the US president tells you not to come to US, you don't go
Rivlin addresses UN at Holocaust memorial
Obama: Netanyahu meeting before Israel election 'inappropriate'
Wolf Prizes in the sciences and arts presented to nine North Americans
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Israeli, Palestinian agriculture officials cooperate to curb bird flu spread
Matchmaker, matchmaker, make me a start-up
Presenting: A cross between a pomelo and an orange and other novel Israeli produce varieties
Delving into the 'Night'
Kelis bringing a taste of 'Food' to Israel - but no milkshakes, please
A taste of Barcelona in Tel Aviv
Nini Hachi revisited
Kiryat Shmona held by Sakhnin, remains in 2nd place
Basketball: Impressive Maccabi Tel Aviv overcomes Real Madrid
Athletes from across the globe flock to Eilat for Israman
Rolling Mac TA Express set for collision with old nemesis Real
US, UK condemn latest Israeli plan for settler housing as 'illegal, illegitimate'
Obama has agreed to 80 percent of Iran's demands in nuclear talks, Israeli officials tell Ch. 10
Rivlin pays condolences to families of IDF soldiers killed in Hezbollah attack
As dust settles on northern front, Ya'alon urges Israelis to visit Golan and Hermon
Hostilities in North give Likud boost in latest 'Jerusalem Post' poll
26 parties submit final lists for election
Yachad and Otzma end furious row and unite electoral lists
Netanyahu puts Bennie Begin back on Likud list
Yisrael Beytenu, Likud MKs petition to ban Zoabi from running in election
Nasrallah confirms Hezbollah, Iran bolstering presence along Golan border
Liberman: Israel's policy toward Hezbollah spurring terror from Lebanon, Syria
Erekat: Recognizing 'Palestine' as a state is best response to 450 new settlement homes
Senators pledge not to support Palestinian aid until US reviews ICC bid
Gazan youth graduate Hamas military training camp
BBC to investigate presenter's Israel questions at Paris protest march
Lithuanian Jews, Zuroff spar over Holocaust research center
Portugal okays law of return for Sephardic Jews
Nightmare for Italian Jewish leader and TV crew after being locked inside Auschwitz
Israel Bonds dinner raises $250 million in investments
Report: Joint Mossad-CIA operation killed key Hezbollah leader Mughniyeh in 2008
At root of Argentina spy intrigue - a deal with Iran
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Israeli claims of major Obama concessions to Iran 'complete nonsense,' US says
Islamic State's Egypt wing claims credit for terror attacks that killed 27
Beshalah: Eating the manna and receiving the Torah
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Reflections: A musical legend
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Xin Chào, Vietnam
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Introducing freedom
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Middle Eastern date desserts for Tu Bishvat
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Netanyahou sous le feu des critiques
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La violence refait surface
La liste de Herzog
Commémoration du 70e anniversaire de la libération du camp d'Auschwitz
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Le 11 septembre français ?
Obama dismisses Muslim faith claims, says he is devout Christian
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Pope Francis calls for Christian Unity
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By JTA \
08/22/2012 09:25
Brit-mila. (photo credit:Reuters)
BERLIN -- A rabbi in Bavaria has been slapped with criminal charges of committing bodily harm, in the first known case to arise from an anti-circumcision ruling in May.The charge against Rabbi David Goldberg, who is a mohel, or ritual circumciser , means that the May decision in the state of Hesse has been applied in Bavaria, confirming the fears of Jewish leaders here that the local ruling would have a wider impact. Goldberg, 64, a Jerusalem native living in Hof Saale in Bavaria, told JTA he had not yet received a notice from the court. He said he would decide what to do after he had seen it. The charge was confirmed to the main Jewish newspaper of Germany, the Juedische Allgemeine Zeitung.The rabbi also said he did not know what act the charges could refer to, since he has not performed any circumcisions recently in Germany. "Only abroad: in Budapest, in the Czech Republic, in Italy," he said.Still, the rabbi said no secular ruling would stop him from performing brit mila (circumcision) in the country. If a family in Germany came to him with a request to perform a circumcision, Goldberg said he would ask the Central Council of Jews in Germany what to do. "A few weeks ago, they said, 'You can continue,'" he said.Goldberg said regional journalists had informed him of the suit, saying it had been filed by a doctor in the state of Hessen who had gathered 600 signatures on an open letter to German Chancellor Angela Merkel that supported the anti-circumcision ruling. Merkel and the German parliament have said, however, that they intend to push for legislation to ensure that Jews and Muslims have the right to carry out the religious ritual.The original ruling in May related to a Muslim family in Cologne whose son suffered complications after his circumcision. The court found that non-medical circumcision of a minor is a criminal act. Although the ruling was local, it has alarmed traditional Jews and Muslims across the country. Virtually all Jewish denominations have joined in condemning the ruling. This week, Israel's chief Ashkenazi rabbi, Yonah Metzger, was in Berlin for high level meetings on the issue.Meanwhile, anecdotal evidence shows that Jewish ritual circumcisions continue to be performed in Germany despite the ruling's chilling effect. Although several hospitals have declared moratoriums on the practice for now, brit mila is being performed in private homes and in synagogues.The head of the Conference of European Rabbis, Moscow Chief Rabbi Pinchas Goldschmidt, said of the lawsuit: "This latest development in Hof, Germany, is yet another grave affront to religious freedom and underlines the urgent need for the German government to expedite the process of ensuring that the fundamental rights of minority communities are protected."
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US 3976776 A Abstract The present invention concerns the class of heterocyclic carbon compounds comprised of N-(heteroarcyclic)piperazinylalkyl derivatives of azaspiroalkanediones which have potent and specific tranquilizing action and anti-emetic properties. Typical embodiments of this invention are 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione and 8-[4-[4-(2-pyridyl)-1-piperazinyl]-butyl]-8-azaspiro[4.5]decane-7,9-dione.
Claims(38) 1. The process for eliciting tranquilizing effect in a mammal which comprises administering systemically to a mammal in need thereof an effective tranquilizer dose of from about 0.01 to about 40 mg./kg. of body weight of said host of a compound selected from a group consisting of compounds having the formula: ##SPC13##
wherein n is the integer 4 or 5; A is a divalent straight or branched alkylene chain of 2 to 6 carbon atoms inclusive and connects the nitrogen atoms as shown through at least 2 carbon atoms; B is a heteroarcyclic represented by the symbol ##SPC14## W and Y are independently selected from the group consisting of CH and nitrogen, R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl from 1 to 4 carbon atoms inclusive, lower alkoxy of from 1 to 4 carbon atoms inclusive, hydroxy, amino, alkylthio of from 1 to 4 carbon atoms inclusive, halogen, trifluoromethyl, alkanoamido of 1 to 6 carbon atoms inclusive, and alkanesulfonamido of 1 to 6 carbon atoms inclusive, and a non-toxic pharmaceutically acceptable acid addition salt thereof. 2. The process of claim 1 comprising the administration of 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]-decane-7,9-dione.
3. The process of claim 1 comprising the administration of 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]-decane-7,9-dione hydrochloride.
4. The process of claim 1 comprising the administration of 8-[4-[4-(2-pyridyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione.
5. The process of claim 1 comprising the administration of 8-[4-[4-(2-pyridyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
6. The process of claim 1 comprising the administration of 8-[2-[4-(2-pyridyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione.
7. The process of claim 1 comprising the administration of 8-[2-[4-(2-pyridyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
8. The process of claim 1 comprising the administration of 8-[2-[4-(2-pyrimidinyl-1-piperazinyl]ethyl]-8-azaspiro[4.5]-decane-7,9-dione.
9. The process of claim 1 comprising the administration of 8-[2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]-decane-7,9-dione hydrochloride.
10. The process of claim 1 comprising the administration of 8-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]-decane-7,9-dione.
11. The process of claim 1 comprising the administration of 8-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]-decane-7,9-dione hydrochloride.
12. The process of claim 1 comprising the administration of 8-[5-[4-(2-pyrimidinyl)-1-piperazinyl]pentyl]-8-azaspiro[4.5]-decane-7,9-dione.
13. The process of claim 1 comprising the administration of 8-[5-[4-(2-pyrimidinyl)-1-piperazinyl]pentyl]-8-azaspiro[4.5]-decane-7,9-dione hydrochloride.
14. The process of clam 1 comprising the administration of 8-[3-[4-(6-methoxy-2-pyridyl)-2-piperazinyl]propyl]-8-azaspiro-[4.5]decane-7,9-dione.
15. The process of clam 1 comprising the administration of 8-[3-[4-(6-methoxy-2-pyridyl)-1-piperazinyl]propyl]-8-azaspiro-[4.5]decane-7,9-dione hydrochloride.
16. The process of claim 1 comprising the administration of 3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-3-azaspiro[5.5]-undecane-2,4-dione.
17. The process of claim 1 comprising the administration of 3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-3-azaspiro[5.5]-undecane-2,4-dione hydrochloride.
18. The process of claim 1 comprising the administration of 8-[4-[4-(4,6-dimethyl-2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione.
19. The process of claim 1 comprising the administration of 8-[4-[4-(4,6-dimethyl-2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
20. A pharmaceutical composition in dosage unit form suitable for systemic administration to a mammalian host comprising a pharmaceutical carrier and sufficient compound to provide an effective daily dose of from 0.01 to 40 mg./kg. of body weight of said host, said compound being selected from the group consisting of compounds of the formula: ##SPC15##
wherein n is the integer 4 or 5; A is a divalent straight or branched alkylene chain of 2 to 6 carbon atoms inclusive and connects the nitrogen atoms as shown through at least 2 carbon atoms; B is a heteroarcyclic represented by the symbol wherein ##SPC16## W and Y are independently selected from the group consisting of CH and nitrogen, R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl from 1 to 4 carbon atoms inclusive, lower alkoxy of from 1 to 4 carbon atoms inclusive, hydroxy, amino, alkylthio of 1 to 4 carbon atoms inclusive, halogen, trifluoromethyl, alkanoamido of 1 to 6 carbon atoms inclusive, and alkanesulfonamido of 1 to 6 carbon atoms inclusive, and a non-toxic pharmaceutically acceptable acid addition salt thereof. 21. The composition of claim 20 containing 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione.
22. The composition of claim 20 containing 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
23. The composition of claim 20 containing 8-[4-[4-(2-pyridyl)-1-piperazinyl)]butyl]-8-azaspiro[4.5]decane-7,9-dione.
24. The composition of claim 20 containing 8-[4-[4-(2-pyridyl)-1-piperazinyl)]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
25. The composition of claim 20 containing 8-[4-[4-(2-pyridyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione.
26. The composition of claim 20 containing 8-[2-[4-(2-pyridyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
27. The composition of claim 20 containing 8-[2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione.
28. The composition of claim 20 containing 8-[2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
29. The composition of claim 20 containing 8-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]decane-7,9-dione.
30. The compositon of claim 20 containing 8-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
31. The composition of claim 20 containing 8-[5-[4-(2-pyrimidinyl)-1-piperazinyl]pentyl]-8-azaspiro[4.5]decane-7,9-dione.
32. The composition of claim 20 containing 8-[5-[4-(2-pyrimidinyl)-1-piperazinyl]pentyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
33. The composition of claim 20 containing 8-[3-[4-(6-methoxy-2-pyridyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]decane-7.9-dione.
34. The composition of claim 20 containing 8-[3-[4-(6-methoxy-2-pyridyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride.
35. The composition of claim 20 containing 3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-3-azaspiro[5.5]undecane-2,4-dione.
36. The composition of claim 20 containing 3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-3-azaspiro[5.5]undecane-2,4-dione hydrochloride.
37. The composition of claim 20 containing 8-[4-[4-(4,6-dimethyl-2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]-decane-7,9-dione.
38. The composition of claim 20 containing 8-[4-[4-(4,6-dimethyl-2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]-decane-7,9-done hydrochloride.
Description This application is a divisional application of our copending application Ser. No. 312,543 filed Dec. 6, 1972, now U.S. Pat. No. 3,907,801 which is a divisional application of Ser. No. 879,604 filed Nov. 24, 1969, and now U.S. Pat. No.3,717,634 patented Feb. 20, 1973. This invention relates to new compounds characterized by the following general structural formula and the non-toxic pharmaceutically acceptable acid addition salts thereof. ##SPC1## In the foregoing Formula I, m is the integer 4 or 5. The symbol --A-- which connects the sprioglutarimide and the N-(heteroarcyclic)piperazine represents a divalent alkylene chain of 2 to 6 carbon atoms inclusive. Said alkylene chain can be straight- or branched-chain hydrocarbon grouping in which the ring connecting bonds are on different carbon atoms such as- ##EQU1## and the like. The piperazine substituent represented by the symbol "B" is selected from the group consisting of 2-imidazolyl and a heteroarcyclic. Said heteroarcyclic is represented by the symbol: ##SPC2## Wherein W and Y are independently selected from the group consisting of CH and nitrogen. By the term "heteroarcyclic" as used herein, it is meant substituents comprised of nitrogen, carbon, and hydrogen which when taken together form a heteroaromatic system. The R1 and R2 substituents of the heteroarcyclic referred to above are independently selected from the group consisting of hydrogen, lower alkyl from 1 to 4 carbon atoms inclusive, alkoxy of from 1 to 4 carbon atoms inclusive, hydroxy, amino, alkylthio of 1 to 4 carbon atoms inclusive, halogen, trifluoromethyl, alkanoamido of from 1 to 6 carbon atoms inclusive, and alkanesulfonamido of 1 to 6 carbon atoms inclusive. By the term "lower alkyl" as employed herein it is meant straight or branched chain alkyl radicals including methyl, ethyl, propyl, isopropyl, 1-butyl, 1-methylpropyl, 2-methylpropyl, and tert.-butyl. Similarly, the alkyl fragment of the alkylthio substituent refers to straight or branched chain radicals described above. Straight or the branched chain alkanes of 1 to 6 carbon atoms inclusive comprise the alkane radical of alkanoamido and alkanesulfonamido groupings. The term "non-toxic pharmaceutically acceptable acid addition salts" as used herein refers to a combination of compounds of the present invention with relatively nontoxic inorganic or organic acids. Illustrative of the variety of acids which may be used are sulfuric, phosphoric, hydrochloric, hydrobromic, hydroiodic, sulfamic, methanesulfonic, benzenesulfonic, para-toluenesulfonic, acetic lactic, succinic, maleic, tartaric, citric, gluconic, ascorbic, benzoic, cinnamic, and related acids. Conversion of the compounds of the present invention to pharmaceutically acceptable acid addition salts is accomplished by admixture of these compounds with substantially one chemical equivalent of any of the various acids hereinbefore defined. Generally the reactions are carried out in an inert solvent. Suitable solvents, merely by way of example, are ethanol, benzene, ethyl acetate, ether, and halogenated hydrocarbons. Illustrative of the nomenclature employed herein for the naming of the products of this invention are partial structures corresponding to the substituted glutarimide portions of Formula I are shown below with the positions numbered. ##SPC3## 8-Azaspiro[4.5]decane-7,9-dione Formula I, n=4 ##SPC4## 3-Azaspiro[5.5]undecane-2,4dione Formula I, n=5 Compounds of Formula I which are particularly preferred embodiments of the present invention are those wherein "n" is the integer 4, the divalent alkylene chain "--A--" is a chain of 4 carbon atoms inclusive and the heteroarcyclic "B" substituent is a 2-pyridyl or a 2-pyrimidyl group having R1 and R2 substituents with the meanings hereinbefore stated. Representative of these compounds are the individually preferred compounds 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione and 8-[4-[4-(2-pyridyl)-1-piperazinyl]butyl] -8-azaspiro[4.5]-decane-7,9-dione. General embodiments of the process for the preparation of compounds of the present invention are schematically illustrated below and labeled Method A, Method B and Method C. The use of a particular method to produce compounds embraced by this invention is dictated to a large extent by conditions which will be apparent to those skilled in the art. In practice, the selection of the method used for the preparation of any one compound of the present invention is principally determined by the commercial availability of the necessary intermediates and/or by the ease which available compounds can be converted to desired intermediates. ##SPC5## ##SPC6## In the foregoing reaction schemes, the symbols n, --A--, and B have the same meanings as previously defined relative to Formula I. The symbol X refers to the acid residue of a reactive ester grouping such as a chloride, bromide, iodide, sulfate, phosphate, tosylate or mesylate. M comprises an alkali metal salt of the substituted glutarimide and is preferably sodium or potassium. Method A is carried out by reacting a spirosubstituted glutaric anhydride of Formula II with the 1-(ω-aminoalkyl)-4-(heteroarcyclic)piperazines of Formula III to provide products of Formula I. Preferably, the reaction is carried out at elevated temperatures in a reaction inert organic solvent. By the term "inert organic solvent", as referred to herein is meant any protic or aprotic solvent or diluent which does not enter into the reaction to any substantial degree. Pyridine is the preferred solvent. Temperatures of about 100�C. to about 200�C. are preferred to facilitate completion of the reaction. The duration of the reaction is critical only to the extent of providing maximum yields and reaction periods of from about 16 hr. to as much as 11 days are preferred. The lengthy reaction periods are necessary in some instances to obtain complete conversion of glutaric acid half-amides of Formula VIII which are initially formed when an anhydride of Formula II is combined with an amine of Formula III. ##SPC7## The glutaric acid half-amides of Formula VIII may be also transformed into Formula I products by heating in boiling acetic anhydride which is a well known standard organic procedure for ring closure useful in the formation of cyclic imides. Method B is carried out under reaction conditions amply described in literature wherein tertiary amines are formed by alkylation of a secondary amine with an alkyl halide, sulfate, phosphate, tosylate, or mesylate. The Formula IV and Formula V intermediates are preferably reacted in an inert liquid reaction medium at temperatures of from about 60�C. to about 200�C. in the presence of a base suitable for use as an acid binding agent. Sodium carbonate is a particularly preferred acid binding agent but other inorganic and tertiary organic base may be employed including other alkali and alkaline earth metal carbonates, bicarbonates, or hydrides and tertiary amines. Reaction periods ranging from about 2 hrs. to approximately 4 days are preferred in order to obtain satisfactory yields of the present compounds. A particularly preferred solvent is n-butanol but any inert reaction medium is generally applicable to use in this reaction. To a large extent, the duration of the reaction period depends upon the temperature and reaction solvent selected. By way of illustration, alkylation is facilitated and the reaction period is appreciably shortened if dimethylformamide is employed as the reaction medium compared to a solvent such as benzene. Method C is another method useful for preparation of compounds of Formula I. In this method, the spiroglutarimide metal salt depicted by Formula VI is reacted with substituted piperazines of Formula VII. Standard laboratory procedures are employed in carrying out the reaction such as those described for the alkylation step of the Gabriel synthesis--S. Gabriel, Ber. 20, 2224 (1887). For example, the reactants are combined in an inert reaction medium at temperatures ranging from about 25�C. to 200�C. Preferred solvents for carrying out the reaction are dimethylformamide, acetone, benzene, n-butanol, ethanol and the like. With respect to the reactants for Methods A, B and C, many of them, including 3,3-tetramethyleneglutaric anhydride, (Formula II, n=4) are known compounds which are readily available from commercial sources. Others, which are not commercially available, can be prepared in accordance with standard synthetic procedures which are known to those skilled in the art. Preparation of N-(heteroarcyclic)piperazines of Formula V have been described by K. L. Howard et al. in J. Org. Chem., 18, 1484 (1953). Their procedures are applicable to the preparation of other N-(heteroarcyclic)piperazine intermediates not specifically disclosed but which are required for the preparation of compounds embraced in the present invention. The 1-(ω-aminoalkyl)-4-(heteroarcyclic)piperazine of Formula III are obtained according to methods described in U.S. Pat. No. 3,398,151 by alkylation of N-(heteroarcyclic)piperazines of Formula V with haloalkylnitriles to provide 1-(ω-cyanoalkyl)-4-(heteroarcyclic)piperazine intermediates which are subsequently reduced to the Formula III substituted piperazines. Reduction of the cyano intermediate may be carried out catalytically, preferably with W-6 Raney Nickel catalyst under high pressure, or alternatively with hydrazine and W-6 Raney Nickel. The intermediate azaspirodecane-and undecanediones of Formula IV having the --A--X group attached to the nitrogen atom are prepared according to procedures described in U.S. Pat. No. 3,398,151. Reaction of the glutaric anhydrides of Formula II with an alkanolamine of the formula H2 N--A--OH are carried out under conditions similar to those described hereinabove for Method A. The resulting intermediate glutarimide has the structure shown for Formula IV wherein X is OH. Esterification of this material is accomplished by conventional techniques well known to the art to provide the intermediate of Formula IV. Preferably, thionyl chloride is reacted with the alcohol precursor of Formula IV (X=OH) to provide the intermediate wherein X is chlorine. Conventional techniques which are adequately described in the literature are employed to provide the bromides, iodides, phosphates, sulfates, tosylates, and mesylates corresponding to Formula IV. The piperazine reactant of Formula VII having the X--A-- grouping attached to the nitrogen atom is prepared according to standard organic procedures. By way of example, reaction of the piperazines of Formula V with alkanol halides of the Formula HO--A--X provides intermediate of Formula VIII. ##SPC8## This intermediate is then esterified according to conventional techniques well known to the art to provide the Formula VII reactants. For instance, thionyl chloride acting upon the compounds of Formula VIII provides the Formula VII intermediate in which X is chlorine. In a similar fashion, bromides, and iodides are prepared. Phosphates, sulfates, tosylates, mesylates corresponding to Formula VII are obtained with conventional laboratory techniques. General embodiments of the process of the present invention for the preparation of compounds of Formula I as hereinabove described are considered to be a unitary process. Thus, the azaspiroalkanedione of Formula I are prepared in accordance with the unitary process of the present invention by reacting a piperazine of the Formula IX. ##SPC9## wherein Y is selected from the group consisting of hydrogen (Formula IXa), H2 N--A-- (Formula IXb), or X--A-- (Formula IXc), and A and X are as hereinbefore defined, with a spiroglutaric acid anhydride of Formula II. ##SPC10## wherein n is as hereinbefore defined, when Y is the group H2 N--A--; or a N-substituted spiro-glutaric acid imide of Formula IV. ##SPC11## wherein A and n are as hereinbefore defined and X is a reactive ester group, when Y is hydrogen; or a spiroglutarimide of Formula VI. ##SPC12## wherein n and M are as hereinbefore defined, when Y is the group X--A--; in the presence of a reaction inert solvent at an elevated temperature. The present invention relates to azaspirodecanedione and azaspiroundecanedione derivatives as hereinabove described by Formula I. In U.S. Pat. No. 3,398,151 reference is also made to derivatives of azaspirodecanediones and azaspiroundecanediones which have a number of pharmacological activities including tranquilizing action. In the instant case, it has been discovered that N-(heteroarcyclic)piperazine alkyl derivatives of azaspirodecanediones and azaspiroundecanediones are highly active and specific tranquilizing agents and in addition also exhibit anti-emetic properties. Present compounds are improved tranquilizing agents compared to the azaspirodecanediones and azaspiroundecanediones of U.S. Pat. No. 3,398,151, in that tranquilizing activity is more potent and specific. With respect to side effects such as sedative and alpha-adrenergic blockade which are exhibited by a number of prominent tranquilizing agents the present compounds are unique in that such adverse reaction is substantially diminished or practically non-existent. By way of illustration, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro-[4.5]decane-7,9-dione hydrochloride has only about 1/400 th. the alpha-adrenergic blocking activity of the well known tranquilizer, chlorpromazine. Tranquilizing properties of the compounds of this invention can be demonstrated in rats by a shuttle box technique described by J. R. Albert and L. E. Allen in the Pharmacologist 4,152 (1962). This test is designed to differentiate tranquilizing agents from non-specific central nervous system depressants such as sedatives and hypnotics. Tranquilizing effects are observed when the compounds of the present invention are administered intraperitoneally to the rat in dosages ranging from 1.5 to 180 mg./kg. of body weight. The tranquilizing action of the compounds of the present invention can be demonstrated in Rhesus monkeys by observing general behavioral effects. Intramuscular administration of present compounds to the monkey in dosages ranging from 2 to 16 mg./kg. of body weight affords tranquilizing effects similar to those produced by chlorpromazine. The compounds of the present invention are relatively non-toxic compounds. For example, the intraperitoneal 50% lethality dose of 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride is 146 mg./kg. of body weight in the mouse. Systemic administration of the compounds of the present invention to mammals in dosages ranging from about 0.01 to 40 mg./kg. of body weight per day induce effective tranquilizing responses in the mammalian recipient. Oral, parenteral and rectal routes are preferred forms of systemic administration. Forms of parenteral administration include intramuscular, intravenous, and subcutaneous administration. Those skilled in the art will recognize that the dosage of the compounds of the present invention will vary with the form and mode of administration and in some instances with the particular compound chosen. Generally, it will be found that when a compound of the present invention is administered orally, a larger quantity of the active agent is required to produce the same effect as a smaller quantity thereof which is given parenterally. It is generally preferred to administer the compounds of this invention at a concentration level that will produce effective tranquilizing effects without causing any harmful or deleterious side effects. For pharmaceutical purposes, the compounds of Formula I may be administered to mammals in the form of free bases or in the form of non-toxic acid additon salts. In the free base form, the compounds are relatively insoluble in water but are soluble in most organic solvents such as lower alkyl alcohols, esters, acetones, chloroform and the like. The present compounds in the form their acid addition salts are, in general, soluble in water and methanol but relatively insoluble in solvents such as benzene, ether, petroleum ether and the like. In either the free base or the acid addition salt form, the compounds of Formula I may be compounded and formulated into pharmaceutical compositions and unit dosage suitable for systemic administration. Organic or inorganic solid materials or liquids which are pharmaceutically acceptable carriers are employed in these pharmaceutical compositions. By the term "systemic administration" as used herein it is meant forms of administration such as oral, parenteral and rectal. Pharmaceutical compositions considered within the scope of this invention may take the form of tablets, powder, granules, capsules, suspensions, solutions, suppositorys, elixirs, ointments and the like. Unit dosages ranging from about 1 to 500 mg. are employed. Suitable pharmaceutical carriers comprise both solids and liquids such as corn starch, lactose, calcium phosphate, stearic acid, polyethylene glycol, water, sesame seed oil, peanut oil, propylene glycol, and the like. The following examples are illustrative of the process and products of the present invention and are not to be construed as limitations of this invention, many variations of which are possible without departing from the spirit and scope thereof. Procedure 1. Condensation with Substituted Glutaric Anhydride. A mixture of 0.1 mole of the substituted glutaric anhydride (Formula II), 0.1 mole of 1-ω-aminoalkyl)-4-(heterocycle)piperazine (Formula III), and 300 ml. of pyridine is refluxed until imide formation is complete. The degree of reaction is readily followed by taking an aliquot portion of the reaction mixture, removing the solvent, and obtaining the infrared absorption spectrum of the residue. When reaction is complete, the spectrum exhibits typical infrared imide bands at 1700 and 1710 cm.- 1. whereas if incomplete, the infrared spectrum contains amide and carboxyl absorption bands at 1680, 1760, and 3300 cm.- -1. The azaspiroalkanedione product is purified as the free base by stripping off the pyridine solvent and crystallizing the residue from a suitable solvent or by vacuum distillation thereof. Suitable acid addition salts of the product are prepared by treating an ethanol solution of the free base with an equi-molar amount of the appropriate acid. Examples of representative compounds of the present invention prepared according to Procedure 1 are indicated in Table I. TABLE I__________________________________________________________________________8-[4-(N-HETEROARCYCLIC)-1-PIPERAZINYLALKYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE PRODUCTS BASE HYDOCHLORIDEExamplePRODUCT B.P.,�C Percent Crystn.No. Method n Het. (mm Hg) Yield M.P.�C. Solvent Formula Analyses__________________________________________________________________________1 A 2 -- -- 208.5-209.5 ethanol C20 H28 N4 O2.HCl C 61.11 H 7.25 N 14.26 Cl 8.812 A 4 255-260 76 172-173.5 2-butanone C22 H32 N4 O2.HCl C 63.01 (0.1) H 7.89 N 13.55 Cl 8.293 A 2 230-250 90 206-207 absolute C19 H27 N5 O2.HCl C 58.00 (0.1) ethanol H 7.23 N 17.75 Cl 9.034 B 3 -- -- 214-215 absolute C20 H29 N5 O2.HCl C 59.06 ethanol- H 7.30 ether N 17.245 A 4 240-265 67 201.5-202.5 absolute C21 H31 N5 O2.HCl C 60.29 (0.1) ethanol H 7.41 N 16.60 Cl 8.486 A 5 260-275 52 188.5-190.5 methanol- C22 H33 N5 O2.HCl C 60.44 (0.07) ethyl ace- H 7.93 tate N 16.017 B 3 260-270 59 233.5-234.5 ethanol C22 H32 N4 O3.HCl C 60.72 (0.2) H 7.73 N 13.01 Cl 7.98__________________________________________________________________________ Procedure 2. Alkylation of N-(heteroarcyclic)piperazines. A mixture of 4.9 g. (0.02 mole) of 8-[3-chloro-1-propyl)-8-azaspiro[4.5]decane-7.9-dione, 3.3 g. (0.02 mole) prepared in the manner of U.S. Pat. No. 3,398,151, N-(2-pyrimidyl)piperazine, and 2.2 g. (0.02 mole) of sodium carbonate in 75 ml. of n-butanol is refluxed for three days and filtered. The filtrate is concentrated in vacuo and the residue taken up in 100 ml. of benzene. Addition of 4.0 ml. of 5.0 N ethanolic hydrogen chloride to the benzene solution of the free base provides the product 8-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]decane-7,9-dione as a hydrochloride salt which is collected and crystallized from absolute ethanol-ether, yield 3.4 g., m.p. 214�-215�C. (corr.). Examples of representative products of this invention and physical properties thereof prepared according to Method B are listed in Table I. Procedure 3. Alkylation of Azaspiroalkaneimides. A solution of 0.1 mole of 3,3-tetramethyleneglutarimide in methanol (150 ml.) is treated with 0.1 mole of sodium methoxide. The solvent is removed in vacuo to provide a residue consisting of the sodium salt of 3,3-tetramethyleneglutarimide which without further purification is combined with 0.1 mole of 1-(2-chlorobutyl)-4-(pyrimidinyl)piperazine in 150 ml. of n-butanol. The mixture is refluxed for a period of time of sufficient duration to provide approximately 0.1 mole of precipitated sodium chloride as a by-product. Isolation of the product by standard laboratory procedures provide 8-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-8-azaspiro[4.5]decane-7,9-dione which is also a product of Procedure 2. Additional exemplification of compounds of the present invention is given in Table II along with the mode of preparation according to Method A, Method B, or Method C and the appropriate intermediates. Although only a single method of preparation is indicated for each example, one skilled in the art can readily appreciate that any of the Methods A, B and C hereinabove described are equally applicable to the preparation of the compounds of the present invention. TABLE II__________________________________________________________________________Additional N-(HETEROARCYCLIC)PIPERAZINYLALKYLAZASPIROALKANEDIONESExampleProductNo. n A Het. Method Intermediates__________________________________________________________________________ 8 5 --(CH2)4 -- A 3,3-pentamethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[2-(pyrimidinyl)]piperazine 9 5 --(CH2)4 -- A 3,3-pentamethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[4-(2,6-diaminopyrimidinyl)]piperazine10 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[4-(2-amino-6-methylpyrimidinyl)]piperazine11 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[2-(4,6-dimethoxypyrimidinyl)]piperazine 12* 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 2-(4-aminobutyl)- 4-[2-(4,6-dimethylpyrimidinyl)]piperazine13 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[4-(2-methylthio)pyrimidinyl)]piperazine14 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[2-(4,6-dichloropyrimidinyl)]piperazine15 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[4-(2-chloropyrimidinyl)]piperazine16 4 --(CH2)4 -- B 8-(4-chlorobutyl)-8-azaspiro[4.5]decane-7,9-dio ne and 1-[4-(2-nitro-6-methylpyrimidinyl)]piperazine17 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[4-(2-methanesulfonamido-6-methylpyrimidinyl] piperazine18 5 --(CH2)2 -- C 3,3-pentamethyleneglutarimide and 1-(2-chloroethyl)-4- [2-(5-nitropyrimidinyl)]piperazine19 5 --(CH2)6 -- A 3,3-pentamethyleneglutaric anhydride and 1-(6-chloro- hexyl)-4-[2-(5-n-butanesulfonamidopyrimidinyl)] pipera- zine20 4 --(CH2)4 -- C 3,3-tetramethyleneglutarimide and 1-(4-chloroethyl)-4- [4-tert.-butylpyrimidinyl)]piperazine21 4 --(CH2)4 -- B 8-(4-chlorobutyl)-8-azaspiro[4,5]decane-7,9-dio ne and 1-[2-(4-tert.-butylpyrimidinyl)]piperazine22 4 --(CH2)4 -- B 8-(4-chlorobutyl)-8-azaspiro[4.5]decane-7,9-dio ne and 1-[2-(6-trifluoromethylpyridinyl)]piperazine23 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[2-(1,3,5-triazinyl)]piperazine24 4 --(CH2)2 -- C 3,3-tetramethyleneglutarimide and 1-(2-chloroethyl)-4- [2-(4-nitro-1,3,5-triazinyl)]piperazine25 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[2-(3-propionylamidopyridinyl)]piperazine26 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[4-(2,6-dimethanesulfonamidopyrimidinyl)]pipe razine27 4 --(CH2)4 -- A 3,3-tetramethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-[2-(4-hydroxypyrimidinyl)piperazine28 5 --(CH2)4 -- A 3,3-pentamethyleneglutaric anhydride and 1-(4-aminobutyl)- 4-(2-pyridinyl)piperazine__________________________________________________________________________ *8-[4-[4-(4,6-dimethyl-2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5decane-7,9-dione hydrochloride. m.p. 216.5-217.5�C. (corr.), crystallized from absolute ethanol-anhydrous ether. Analysis - Calcd. for C23 H36 ClN5 O2 : C, 61.38; H, 8.06; N, 15.56. Found: C, 61.26; H, 8.10; N, 15.33. Procedure 4. 1-(3-Cyanopropyl)-4-(2-pyrimidinyl)piperazine. A mixture of 1-(2-pyrimidinyl)piperazine (6.0 g., 0.04 mole), 4.6 g., (0.044 mole) of 3-chloropropionitrile and sodium carbonate (4.24 g., 0.04 mole) in 50 ml. of n-butanol is gently refluxed for 16 hours. The reaction mixture is concentrated in vacuo and the residual oil dissolved in about 100 ml. of cyclohexane. On standing a white crystalline material separates which is crystallized from cyclohexane to provide 6.5 g. (yield 70%) of the cyano intermediate, m.p. 56.6�-58�C. Representative examples of cyano intermediates useful in Procedure 5 along with information relative to the preparation thereof according to Procedure 4 are listed in Table III. TABLE III__________________________________________________________________________1-(ω-CYANOALKYL)-4-(HETEROARCYCLIC)PIPERAZINESIntermediate B.P.,� C. M.P.�C. AnalysisNo. Het. n Yield (mm Hg) (Crystn. Solv.) Formula C H N__________________________________________________________________________1 1 82 163-165 -- C11 H14 N4 -- -- -- (0.08)2 3 92 185-205 47-49 C13 H18 N4 -- -- -- (0.02) (cyclohexane)3 1 80 -- 98-100 C10 H13 N5 59.12 6.62 34.77 (cyclohexane)4 3 70 -- 56-58 C12 H17 N5 62.04 7.31 30.08 (cyclohexane)5 4 80 -- 77-78 C13 H19 N5 63.49 7.62 28.41 (cyclohexane)6 3 87 -- 191-192 (methanol) C12 H19 N7 55.07 7.28 37.847 3 46 220-235 -- C14 H21 N5 O2 56.90 7.01 23.41 (0.1)8 3 100 245 109-110 C13 H20 N6 59.94 7.66 32.48 (Crude) (0.15) (ethyl acetate- Skillysolve F)__________________________________________________________________________ Procedure 5. 1-(4-Aminobutyl)-4-(2-pyrimidinyl)piperazine. A. A solution of 1.5 g. (0.05 mole) of 1-(3-cyanopropyl)-4-(2-pyrimidinyl)piperazine in 150 ml. of absolute ethanol is saturated with ammonia. W-6Raney Nickel catalyst is added and the mixture hydrogenated under 1200 p.s.i. When the hydrogenation is completed the mixture is filtered and the residual oil distilled under reduced pressure to provide 8.2 g. (70%) of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine. Reduction of cyano intermdiates of Procedure 4 in the manner described for Procedure 5 or alternatively by reduction with hydrazine and Raney Nickel provide the amino intermediates of Formula III. The following procedure is illustrative of hydrazine and Raney Nickel reductions. B. Hydrazine hydrate 85% (640 ml) is added dropwise to 4-[-(2-pyrimidinyl)-1-piperazinyl]butyronitrile (189.8 g., 0.82 mole), Raney Nickel (190 g. - wet with water, activated by washing with 2-propanol) and 2-propanol (1.4 liter) in 2 hours at reflux. The reaction is stirred for 5 minutes, filtered, concentrated in vacuo and the residual material distilled to yield 168.2 g. (87%) of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine, b.p. 143�-6�C. at 0.1 mm (ND 26 1.5582). Procedue 6. Solution for Parenteral Injection. The azaspiroalkanedione compounds of the present invention are formulated for parenteral administration according to the following example. A sterile solution suitable for intraveneous injection is prepared by dissolving 21.9 g. of 8-[4-[4-(2-pyrimidinyl)-2-piperazinyl]butyl]-8-azaspiro-[4.5]decane-7,9-dione hydrochloride in 2 liters of water for injection, USP. The solution is adjusted to pH 4.2 with 0.1 N-sodium hydroxide. After adjusting the pH, the solution is sterilized by passage through a bacteriological filter and 10 ml. glass ampules aseptically filled in order to provide 10 mg. of active ingredient per ampule. Procedure 7. Tablets. The azaspiroalkanedione compounds of the present invention are compounded into tablets in accord with the following example. ______________________________________Material Amount______________________________________8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]- 54.8 g.butyl]-8-azaspiro[4.5]decane-7,9-dionehydrochlorideMagnesium Stearate 1.3 g.Corn starch 12.4 g.Corn starch pregelatinized 1.3 g.Lactose 180.2 g.______________________________________ The foregoing materials are blended in a twin-shell blender and then granulated and pressed into tablets weighing 250 mg. each. Each tablet contains 50 mg. of active ingredient. Patent Citations
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Pages: 408
Publisher: Packt Publishing
Back in 2004, the company behind the then-popular blogging platform Movable Type shot themselves in the foot by changing the license, prompting the majority of top users to select an alternative platform. Ever since then, Wordpress has been thriving and has ultimately become one of the leading online publishing platforms. In fact, WordPress.com alone is home to more than 60 million hosted blogs.
Wordpress is an open source project and one of the major reasons for its popularity is its community, which developed over 23,000 plugins. The diversity of these add-ons is impressive, but they also strongly impact the overall security of the installation.
If you host your blog on WordPress.com, security is not something you should worry about too much. But for those who don't and use Wordpress it's important to keep up with the constant updates of both the core installation as well as the plugins.
Inside the book
This book has over 350 pages and, as the title says, aims to be the ultimate Wordpress 3 security guide. The author built the book around the premise that a website is as safe as the weakest link.
I absolutely agree with this and was satisfied when the author started with explaining the risks, likely threats and ways to securing a system that will be used by the WordPress administrator.
Unfortunately, as the dialogue about the user's own computer security went on and on, I realized that he had focused too much on this - a mistake that he repeated when discussing the security of the server the blogging system is installed on.
I absolutely understand the need of providing background information that would be of interest to any WordPress administrator, but to tell you the truth, I expected more from a book titled "WordPress 3 Ultimate Security".
The security information provided - that is, the information about issues that are not directly connected to WordPress - are well organized, but they occupy most of the book.
The first 300 pages (appendixes start on page 313) contain barely 50 that had something to do with security threats or hardening of Wordpress. Add to that the extra 20 pages from the appendix A and B (a list of information security plugins and a solid piece on WordPress disaster recovery), and... that's it!
Final thoughts
I think it's fair to say that 20 percent of the book dedicated to what should be the main thing is not nearly enough for a publication whose title contains the term "ultimate". Exchange that 20 percent about Wordpress with the same amount of information about Joomla, PhpBB or similar, and you could publish a book every month - but none of them would deserve the aforementioned term.
On the positive side, the content that is dedicated to WordPress hardening is very interesting and the author gives good tips that will definitely help you increase the security of your WordPress installation.
Email scammers stole $215M from businesses in 14 months
Posted on 29 January 2015. | In 14 months there have been nearly 1200 US and a little over 900 non-US victims of BEC scams, and the total money loss reached nearly $215 million.
How much can a DDoS attack cost your organization?
Posted on 29 January 2015. | A DDoS attack on a companys online resources might cause considerable losses with average figures ranging from $52,000 to $444,000 depending on the size of the company.
Reactions to the serious vulnerability found in Glibc
Posted on 28 January 2015. | Researchers found a critical vulnerability in the Linux GNU C Library (glibc), that allows attackers to remotely take control of an entire system without having any prior knowledge of system credentials.
How GitHub is redefining software development
Posted on 26 January 2015. | The security industry is slowly realizing what the developer community knew for years - collaboration is the key to and likely the future of innovation.
DMARC: The time is right for email authentication
Posted on 23 January 2015. | The DMARC specification has emerged in the last couple years to pull together all the threads of email authentication technology under one roofto standardize the method in which email is authenticated, and the manner in which reporting and policy enforcement is implemented.
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Creating beautiful, lasting images is our passion at Edmund Keene Photographers. We offer a tantalizing mix of black and white or color images that capture your wedding day as it unfolds.
I love photographing weddings and the emotion its capable of evoking. I approach your day with an eye for detail, romance and simple beauty, combining candid journalism with an editorial edge.
Luna Image Co. is a collaborative two man photography team specializing in the modern and contemporary. We both have very unique styles as one is more geared towards a photojournalistic style and the other focuses more on fine-art.
Photojournalistic, relaxed, candid, artistic, detailed photography by Duval Photography. Travel welcome at no extra charge.
Candid and relaxed b&w photography. Melissa has been doing weddings for 15 years. Visit her online portfolio.
Passionate to pursue finding beauty in the emotions of your wedding day- the seen & the unseen- these moments make life art!
Congratulations on your Engagement! For over 12 years Laura Sonnenberg has captured the emotions & details of wedding couples. If you care about quality and are looking for a photographer with style, experience & an artistic eye, then I'm your girl...your wedding imagery is priceless and cannot be duplicated & I get that!!
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Your wedding day will be filled with unforgettable moments that will last a lifetime, and it's our joy and privilege to capture them for you! Wedding coverage starts at $1,500 with engagement session.
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Celebrate your love...<br> Award winning wedding photographer specializing artistic photojournalism and traditional photography to capture the magic of your perfect day.


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Featured news
Technologies to address the problems above are fairly mature and provide an automated method for discovering potential cyber-criminal activities. Security Information Event Management (SIEM) products were historically focused on analyzing network activities, but recently those same analytical techniques have been applied to monitoring fraudulent activities. The key concepts are the same: collect activity information, evaluate each activity both on its own and in conjunction with others to determine if something seems unusual, and then escalate those events that are worth immediate investigation while filtering out those that are just noise.
If done correctly, SIEM can help detect unauthorized activities, whether on the public e-commerce site or on the internal network, with fewer people and faster response. Modern SIEM products include rules, reports and dashboards tuned to monitor fraudulent activities. One financial services organization implemented such a solution and discovered and prevented $900,000 of wire transfer fraud within the first week of deployment.
Organizations that are considering a SIEM solution should think beyond simple network monitoring; the modern SIEM can do much more.
ArcSight is exhibiting at Infosecurity Europe 2009 held on 28th 30th April in Earls Court, London.
Infosec management strategies and the modern CTO
Posted on 21 January 2015. | Brandon Hoffman, Lumeta's CTO, talks about the management strategies that are essential in the information security industry. He also offers advice to those stepping into the CTO role for the first time, and talks about the evolution of network situational awareness.
Cybersecurity readiness: Widening gulf between perception and reality
Posted on 20 January 2015. | Attackers have become more proficient at taking advantage of gaps in security to evade detection and conceal malicious activity, according to Cisco.
2+ million US cars can be hacked remotely, researcher claims
Posted on 19 January 2015. | Security researcher Corey Thuen has made a surprising discovery when he reverse-engineered the firmware of the Snapshot tracking dongles that US-based Progressive Insurance gives out to its customers.
Has the time come to give up penetration testing?
Posted on 19 January 2015. | Rather than spend resources on measures such as pen testing, its now perhaps more relevant to find ways of monitoring for, rooting out, identifying and taking remedial action against malware and threats already inside a network.
19,000 French websites hit by DDoS, defaced in wake of terror attack
Posted on 16 January 2015. | Since the three day terror attack that started in France with the attack on satirical newspaper Charlie Hebdo, 19,000 websites of French-based companies have been targeted by cyber attackers.
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More About WYOBABYFACE
Visit My SparkPage
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Recipes I've Shared:
Wyobabyface's Tuna Salad
This is a quick easy tuna salad, that is yummy either cold or made as a tuna melt.
Wyobabyface Corned beef and cabbage
Needed to do the info on this irish favorite...is pretty high in fat content and sodium. But once a year enjoy this favorite dish :)
Wyobabyface's American Cheese Grilled Cheese
Just wanted to get nurtritional value on a regular grilled cheese, but here it is if you need it :)
Wyobabyface's Tuna Salad Sandwiches
This is yummy and a great filling lunch. I love Tuna and sometimes add boiled eggs to this.
Wyobabyface's Runza Pitas
You can make with Pita's or I also use frozen bread dough to make homemade goodness German cabbage burgers or Runzas
Chicken Manicotti
Easy to make - great with leftover chicken breasts. Family loved it. Couldn't tell it was lowfat.
Recipes I've Rated:
- Sweet Tea
- Tortillia Pizza
- Egg Salad
- onion soup
- Atomic Chicken Nuggets
- watts tex mex soup
- cheeseburger goulash
- Low calorie enough to eat all you want chili
- Center St. Pizza
- Taco Soup ajii
- Super Quick Meatballs
- corn and potato chowder
- creamy reuben soup
- tuna sandwich and salad
- Chulent
- Momma's Meatloaf


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Touchscreens eliminate the need for buttons, just like zippers or TVs powered by yelling. Touch the future with this Groupon.
Choose from Four Options
- $139 for glass replacement for a Samsung Galaxy S3 (a $280 value)
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- $125 for digitizer replacement for an iPad 2, 3, or 4 (a $200 value)
Cellular Repair Center
For nearly three decades, the skilled technicians at Cellular Repair Center have been restoring the delicate electronics of mobile phones and devices, building a wealth of expertise in gadgets from Apple, Samsung, LG, and other popular companies. Cellphone whizzes can tackle nearly any problem on a range of devices, from restoring a cracked touchscreen on a new iPad or repairing a classic Razr to reattaching the string to a pair of tin cans.
Fast and relatively inexpensive iPhone 4s screen replaced!
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They showed great customer service by considering my location and my schedule, as well as fixing my phone as they said they would
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96% of 27 customers recommend
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"They did a great job, my IPHONE 4 looks brand new"


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ok, here is the whole picture (not just a close up like my other one) and again.... I LOVE IT!
Kachikamac (Fan Art Portfolio) Falling Petals
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I travel a decent amount, so I've become something of an expert packer. I can fit a week's worth of clothes in a carry-on bag. When I take vacations with my husband, he and I fit everything we need into a single medium sized suitcase.
How is this possible, you ask? Easy. I adopt a mercenary approach: I think about overlap and what can be eliminated. No emotions. No wishy-washy indecision. I am an unfeeling machine: It's yes or no. This has been great practice for the new checked baggage charges adopted by most airlines. Here's a quick outline of what I do:
- Determine the most versatile jeans to wear on a few occasions. Dark or medium-blue ones with little to no embellishing or fading. That means you can wear them a number of times without anyone noticing – and they look cleaner for longer.
- I figure out my color story for the trip. I usually keep it pared down to black and some neutrals, with few to no patterns, unless they will work for more than one outfit. I pack a few accessories if I want something colorful or special, since they're small and won't take up much space.
- I limit the number of shoes to two or three pairs (wearing one of them on the plane – always a slip on) and again make sure the shoes will complement at least two different looks.
- I make use every bit of space -- including the interiors of my shoes. That's where I store socks and underwear.
- I keep my quart-sized dopp kit packed and ready to roll with travel-sized bottles that can refilled. It goes right back into my closet when I return home, filled with everything I'd need for the next long weekend.
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text:
This is the main character to my short manga "Sing It Loud". Thing is, I have so many ideas for it, it might turn out to be more than a short manga >.<'' Lol...
This is also my entry for Mad Hatter Belia's contest! Woo! Lol
So tell me what you think!
Rein Akira (Fan Art Portfolio) Kokoro Miyasaki
- Created
- 02/28/09
- Category
- Original Anime and Manga Fan Art
- Tags
- it, kokoro, kokoro miyasaki, loud, miyasaki, rein akira, sing, sing it loud
- Views
- 391 views
- Votes
- 29 votes
- Favorited
- 14 members
- Member Dedication
- Mad Hatter Belia
- Feedback
- 4 comments
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