text:
my summer
All Comments
Beautiful summer pics!!! Great body and cock!!! Alex
wonderful wood!
Beautiful pics!!
Sexy srtong body, thick cock & very cute guy!!!
HOTTTTT Pixxx!!!!! Man, I would love to ecounter you naked in the woods!!!! I just know you give me MAJOR wood by looking at these pixxx! Cheers! XXX
Sexy body and beautifull dick!
very hot guy, nice exhib
http://www.xtube.com wish it was shoved in my arse
Ммммммммммммммммм.... СЕКСИ!!!!
супер! )
hot set of pics, love being naked outdoors
Awesome Fuckin Sexy - Man YOU have got it - would love to see you in the wood's to suck your awesome cock and more - thanks for sharing
Very hot photo's!
like to find you in the woods
yummy my man!!!
Very hot man!
http://www.xtube.com are so fuckin hott! love to try that out!
Hot pics!
Beautiful hot man.
i like 'YOUR' summer :P


text:
Use code HA9MWXdetails >* To Save 10% on orders $249 or more. Use promotion code HA9MWX during checkout. Discount does not apply to shipping charges, delivery surcharges, duties or customs fees and cannot be combined with any other offer. Promotion cannot be used on previous orders. This promotional offer may be modified or terminated at any time. Offer expires 12/27/2014 at 11:59pm ET.
A Create-A Custom Wine Bottle Label will instantly spark conversation at your next event!
Dare to Compare!
Personalized Wine Bottle Labels
Do you have questions about this product?(earn points for answers!)
get answers from real customers and in-house experts with AnswerBox.
1 answer
A:All 12 quantity will be imprinted with all the same information. You are not able to individually personalized each label

subset: commoncrawl


text:
It can get pretty hot down in the Caribbean, but things will really heat up for you if you take some time to watch this site's hotties go at it. Most of the babes hook up with other chicks for some lesbian fun outdoors, but you might run out of content before long because updates are rare and there aren't many scenes to begin with. At least quality is good.
Do you have an item laying about your house that you think might get you some cash from a pawn shop? Well, it just might, but if it doesn't (and you happen to be a hot chick), this pawn shop owner will strike up a little deal that involves a little suck and fuck for cash. These babes are a little reluctant at first, but the flash of cash gets them going!
Experience goes a long way when it comes to laying it down in the bedroom and the mature babes in this collection can attest to this. They've got nice, ripe boobs and thick, juicy pussies that can't wait to engulf a nice dick. These honeys aren't even that old, either. They're just mature enough to skip all the games and go for what they want - a hard cock.
Yummy mommies have found their way to Las Vegas and they've made friends there already. Those friends are hung and horny guys who can't wait to show the sexy MILFs a good time. For these ladies, a "good time" involves the two of them going down on each other and fucking until it's time for the guy to shoot a large load all over the sexy woman's waiting face.
Bored at work or even on the ride there? Check out the masturbating and hardcore sex that your coworkers and fellow commuters use as a way to pass the time. Apparently, people are behaving badly in public without knowing that a spy/security cam is catching them in the act. But, as hot as that sounds, the site and its average-quality vids just isn't great.
Hannah is a softcore hottie who loves giving the camera a look at her body, but while always keeping one thing to herself - her pussy lips. You can see that she shaved her pubes right off and her tits and ass are out there to be filmed and photographed as well. But her pussy lips? Those she keeps hidden behind her hands or in some other softcore fashion.
You and I might not get to play with Alicia, but on her mobile site, when she isn't posing for the camera alone, she will bring in another hottie to expose herself with. These playful scenes are softcore and only partially nude, but seeing two sexy teens with their tits out and a pair of pretty panties on, touching each other, is never a bad thing, right?
Honey, candy and Emily. What do those three have in common, you ask? They're all very sweet. What makes Emily the sweetest of them all is the fact that she likes to show off her hot body in bikinis, in lingerie and also in nothing at all. Besides stripping and posing for you, this sexy brunette also likes to play with her wet pussy and pinch her nipples.
Kalee is a Southern belle with sexy boobs. Big boobs, at that. Don't just take our word for it, though. Be sure to take a look for yourselves, because she gives you plenty of chances to see her sweet jugs. You'll also see her pussy, often while she's filling it with all kinds of sex toys. Oh, and don't leave before she gets to show off her blowjob skills.
If you like feisty brunette babes, then Sasha is going to be your new best friend - with benefits. This hottie loves to show off her sexy tits and ass, which means that you get plenty of chances to see her pose in nothing but a bikini, if even that. She's frequently naked and also likes some hot WAM fun mixed in with her lesbian sex every now and again.
We've all got places to be, but let's not lose sight of what's really important. You can still get your fix of transsexual porn wherever you go thanks to mobile sites like this one. Here you'll see gorgeous trannies from Brazil and Asia engaging in masturbation and hardcore sex. You'll see loads of blowjobs and lots of anal action, including interracial sex.
BDSM has grabbed hold of the iPad. Watch a slave lick her Mistress's feet and get an orgasm in return or delight in seeing a gal get her tattooed back flogged and her pussy lips stretched. If you have been thinking about buying an iPad, here's a great reason to start shopping. Wax play, spanking, bondage and more are all yours with the touch of a button.
Amateur MILFs are so much fun. They are hitting their sexual prime and they are so horny they just want to suck and fuck and they don't care who films it. Well, at least that is the case for all the hot mature babes on this site. From ladies sucking cock POV style to babes getting slammed in their butts doggy style, they are all right here to be enjoyed.
The crazy thing about hentai porn is that just about anything goes and you'll quickly find that out after seeing what goes down in this collection. Watch animated flicks with busty babes fucking, sucking cock, engaging in bondage and doing lots of other hardcore acts. They find themselves in all sorts of kinky situations - come witness it all for yourself.
Now you can have hardcore porn featuring Latina hotties right in your pocket (or wherever you keep your smartphone/mobile device). Whip it out and these horny babes will be sucking dick, licking pussy, getting fucked and swallowing cum right there in the palm of your very horny - and happy - hand. What you go and do with your other hand is your own business.
X-rated cartoons can be enjoyed whenever and wherever when you're a member of this mobile website. It's got raunchy videos in which gorgeous toon chicks have a whole lot of sizzling sex. They can be seen baring their tits, hooking up with other beauties, stroking dick, sucking cock, fucking and getting jizzed on. Some gals even take on a few dudes at a time.
Some people only watch porn for the money shot and tend to get rather annoyed when the scene fades to black or cuts out right when the guy's about to jizz all over a chick's tits, face or booty. You don't have to worry about that here, though, because the whole point is that only scenes with cumshots in them are featured. Watch babes get splattered in cum!
These older women are so damn horny that they'll fuck anywhere and anytime. Luckily for you, you can watch them do what they do best wherever and whenever you want as long as you've got a mobile device with an Internet connection. You can see these mature ladies getting nasty with college-aged guys and other mature women and also cumming all on their own.
She bangs! She bangs! And so does just about everyone else on this mobile website devoted to sexy MILFs and the people who love them (and love fucking 'em). You'll largely be treated to scenes of one yummy mommy getting fucked hard by one horny guy, but there are also movies involving masturbation, lovely lesbians, interracial lovers and raunchy group action.
Kayla is a very sexy British beauty with nice tits and a deliciously shaved pussy. She loves to get naughty for the camera and she does so by stripping and spreading her slender legs in order to get her fingers and/or a dildo up in between those pink pussy lips. The cameras catch all the sensual masturbation and all you have to do is sit back and enjoy it.
This babe has her boyfriend's name, "Shaun," tattooed on her lower back and she loves dancing and stripping and showing off her slim body and pink pussy for him and his camera, which means we get to see it also. She is sexy and smiling - two things that go together very well. Just like her hot body and no clothes on or her spread legs and... you get the idea.
Julie is a total hottie and you'll want to get a look at her amazing body. Accidental rhyming schemes aside, she's got a large set of juggs that will get you salivating, as well as an amazing booty that's nice and juicy. Thankfully, her site is all about showing off her goodies. Joining her site means getting to watch her tease, flash and strip just for you.
If you like seeing hot babes in panties and also enjoy viewing porn while you're out and about, joining this site might be something to consider. However, you should be aware that all of its videos are nonexclusive. You should also know that the movies don't look as good as they could. This is largely due to the fact that the flicks are amateur productions.
You might want to check out these curvy Caribbean amateurs who step out into nature to play with themselves and they prefer to do their masturbating under a waterfall, in the forest or on the beach. The don't seem to be updating very often and the video quality's not the greatest, but you don't often find porn with fat gals from the Caribbean for your mobile.
These shemales all have the biggest, thickest cocks in porn as well as perfect hair, amazing asses, beautiful faces and incredible tits. They weren't born perfect, though, they were drawn that way. This site is loaded with the hottest hentai trannies around and they can be seen fucking and sucking in erotic manga and toons, still drawings, CGI and hentai.
Watch as beautiful and sexy Japanese chicks suck cock, get fucked and moan loudly as they get a hard Asian cock filling their hole and then wait for a big load of Asian man-milk to do the same. From threesomes to blowjobs to some kinky sushi-in-pussy eating, this porn collection covers many niches and they are all hardcore and hot authentic Japanese vids.
Women from the UK are gorgeous and you can see some of the United Kingdom's most beautiful ladies by visiting this mobile site. The babes like to pose for you and they're happy to take off their clothes as well. The naughtiest chicks let you look on and they strip with other cuties and fool around with them. It's so hot to see them going down other gals.
The famous porn film "Deep Throat" is a classic and it is movies in that vain that you will see here. They are all porn films from the '70s and '80s when the industry was rocking and stars were made who are still household names today. Come check out a little classic porn history, from Linda Lovelace to "Debbie Does Dallas" to many more old-school classics.
Whether you're out on the town or jumping out of an airplane, you can access this "extreme" bisexual porn whenever you want. Break out your mobile device and enjoy the sexy sights of two guys and a gal getting naked and nasty together. Cocks get sucked, pussies get stuffed and asses get fucked. The end result is that everyone involved ends up very satisfied.
The babes here aren't pornstars or models that you'll recognize. No, they're everyday chicks who all happen to have a naughty side. They're all black beauties who have been filmed and photographed being pretty raunchy. They can be seen posing for sexy selfies, dancing, stripping, masturbating, sucking big dicks and even having some hot sex with horny guys.
Audrey Bitoni gets her poon pounded. Gorgeous Vanessa Lane screws a stud outdoors. That's the XXX action that'll make you cum and it's all here and ready to be loaded onto your mobile device. There is a ton of porn to get you hot and you never have to leave it all at home again. If the non-exclusivity isn't an issue for you than it is worth checking out.
Despite its tour promising thousands of photo sets and videos that focus on user-submitted content, this site actually gets you a few hundred nonexclusive vids with an assortment of hardcore fucking and handjobs starring small-time and big-name pornstars. Plus, the quality isn't all that impressive. Your membership does come with mobile bonus sites, though.
The sexy toons on this site are nothing like the ones you grew up with. They're all sexy shemales who have great tits and huge cocks. You can catch the chicks with dicks playing with themselves and having a whole lot of fun with others. Watch as cocks are stroked, clits are licked, pussies are fucked and tight asses are stuffed with massive cartoon schlongs.
Stunningly beautiful babes from different countries represent their teams by dressing up in little shorts and a soccer jersey. Then they strip out of them on a patch of grass while spreading their legs and showing off all of their goodies for the camera, caressing themselves and letting their fingers go everywhere you wish your fingers could be going.
Blonde babe Sophie may be a virgin, but that doesn't mean this hottie doesn't know about the joys of orgasms and how to give herself one. In fact, this babe may have never had a cock inside her, but the same can't be said for dildos and vibrators. She loves her sex toys and she wants you to watch her get naked and use them on her sweet, wet, hairy pussy.
Naughty little Miko is a sexy Asian cutie with an amazing body. She's got small breasts, a perfect ass and sweet smile that will make you melt. Maybe calling her naughty isn't fair, because she is nice enough to let you stick around while she strips out whatever she's wearing. Before doing that, she also poses for a bit in her sexy lingerie and bikinis.
Max is one lucky dude because his wife loves to make homemade sex tapes. It doesn't take much for her to drop to her knees and take his cock in her mouth and they also do it all over the house. They don't feel confined to suck and screw indoors, though, as they also get freaky in many outdoor locations, like the beach and park. They also get funky in the car!
Black babes sucking cock and riding those same dicks until their pussies start gushing juice. What more could you want? How about interracial fucking, lesbian licking and fun with sex toys as well? We ask because you'll find all of that on this site that's dedicated to bringing you the hottest black chicks around. The action doesn't stop until everyone cums!
These chicks are obviously not virgins and just cause they are pregnant doesn't stop them from fucking and filming it with their lovers. Some of the girls prefer to role solo in their photos and vids, but there are plenty who crave that hard cock in their warm mouths and soaking-wet pussies. Some of these hotties even need two hard cocks at the same time.
Jessica is a young hot British babe who is also a virgin. But that doesn't mean she isn't naughty, as is evident by the sexy videos and photo sets she has put on her site. Some are softcore solo and others get her pussy more involved in the pleasure she is giving herself. In one video she does it with a long lollipop which is just sweet, don't you agree?


text:
Item: U20248
|5 - 10
|$99.74 each
|10 - 20
|$94.49 each
|20 - 40
|$89.24 each
|$83.99 each
Reviewed by deborah b.
on Saturday, June 30, 2012
Clear Vinyl Siding Hanger
I used them for my hanging items on our deck and will use them for my christmas lights also. On my siding though, it's little difficult to get in, but afterwards they're diffently not coming out. One thing though, they are little pricey.


text:
Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
Sort by: Date | Rating | Most Helpful
"Fabulous! Made half the recipe 1st time and it turned out great. Cupcakes very moist and full of banana flavour. The icing is think and not too sweet (I didn't use quite the whole amount of icing sugar). Just the way I like it!"


text:
Join Miami Culinary Tours for a leisure walk though the neighborhood to learn about the massive enchanting murals, street artists and the inspiring history of Wynwood while we visit 5-6 top restaurants to taste exquisite cuisine and local beer. Savor the cuisine from some of the most talented chefs and kitchens in town and get to learn about the culture behind the food. The Wynwood Food Tour is both educational and oh so delicious!
Call or Text 786-942-8856 or book online at www.miamiculinarytours.com
Occurring every Second Saturday of every month between the hours of 6PM to 10PM and extending throughout the night, this monthly happening features openings at Art Galleries, Art Institutions, and Retail Businesses. Thousands of people crowd the streets to have a great night out and enjoy the Miami Art Scene. Join us each month for this festive and lively evening!
Art Wynwood 2014 will feature 70 international galleries featuring emerging, cutting edge, contemporary and modern works and will have its own distinct identity and design. A unique feature will be the highlight of street art, murals, pop surrealism and other genres from the contemporary underground movement. Visit their site at www.artwynwood.com


text:
Coupon Codes for Flickr
Listed below you'll find some of the best flickr coupons, discounts and promotion codes as ranked by the users of RetailMeNot.com. To use a coupon simply click the coupon code then enter the code during the store's checkout process. Learn moreMore »« Less
Current Top Flickr Coupons
- Coupon Code:Show Coupon CodeFLICKR20
Sign up for Flickr Pro today and get 20% off prints and photo gifts with coupon code:SAVE COUPON
- Coupon Code:Show Coupon CodeSFMOMS
Get $50 off any Vizit frame with SFMOMS. You can automatically sync your photos from flickr, facebook, etc. directly to a Vizit frame, regardless of location. For example, we take our baby photos at our home in San Francisco, and my Moms frame in Florida is updated. Best Christmas present for grandparents!!Shared by jilladavisSAVE COUPON


text:
AF Lighting 617627 3 Light Down Light Chandelier in Brushed Nickel with Alabaster Shade
Brighten your dining area or foyer with a contemporary chandelier in a modern brushed nickel finish.
- Brushed Nickel finish
- UL Listed
- Requires (3) x 100 Watt Medium Base Bulbs (Not Included)
- Width: 22"
- Height: 16"
Additional AF Lighting Links
- View Manufacturer Warranty
- Shop All AF Lighting Products
- Shop All AF Lighting Incandescent Collection Products
Our SKU: AF Lighting 617627
This product is listed under the following manufacturer number(s):
- AF Lighting 617627
Brushed Nickel
*Denotes a finish or option that has been discontinued
Product Videos
How To Install a ChandelierMario shows you step by step how to install a Chandelier.
Installation Resource Center
Whether you are installing the product yourself or hiring a professional, our installation Resource Center has everything you need to get your project done. Visit the Installation Resource Center to get started.


text:
It might have felt like a stretch at times but click on the photo for a list of "10 things the Angels got right in 2010." For more news, check out the Angels Blog. For Angels history, check out the Los Angeles Angels of Anaheim/OC Register WIKI.
After six consecutive winning seasons and five division titles in that time, the Angels' 80-82 record and first playoff-free October since 2006 will give them plenty to chew on this off-season.
"Our season is very disappointing," Angels manager Mike Scioscia said as players cleaned out their lockers last week. "I think the frustration is over. When you're going through the process, you're frustrated and we certainly had our share. Now we're going to take the bright spots of this year and move forward and have a better year next year. That's what we're focused on."
I know, I know – your first reaction is, "There were bright spots?"
It might have felt like a stretch at times but click on the photos for a list of "10 things the Angels got right in 2010."
Wednesday, a much easier list – "10 things the Angels got wrong in 2010."
Comments are encouraged, but you must follow our User Agreement
Keep it civil and stay on topic. No profanity, vulgarity, racial slurs or personal attacks. People who harass others or joke about tragedies will be blocked. By posting your comment, you agree to allow Orange County Register Communications, Inc. the right to republish your name and comment in additional Register publications without any notification or payment.


text:
Originally published October 14, 2007 at 12:00 AM | Page modified October 14, 2007 at 2:01 AM
Pinkies up: tea with the first lady
Mary Mitchell wore white kid gloves — the same ones she wore at her wedding — to tea at the White House on Tuesday afternoon...
Seattle Times columnist
Mary Mitchell wore white kid gloves — the same ones she wore at her wedding — to tea at the White House on Tuesday afternoon. The occasion was to honor Letitia Baldridge, an etiquette expert and author who served as social secretary to Jacqueline Kennedy. Mary, a Seattle-based Miss Manners-type who writes the Nice Matters column in The Seattle Times, was invited by the hostess, Laura Bush, because she is a close friend of Letitia, who gave Mitchell away via speakerphone when she married her college sweetheart in a conference room at a Seattle law office.
The tea was "quite dazzling," Mary reports, with more roses and pearls than one might ever see under one roof, and pistachio cookies "to die for." The souvenir she most coveted from her tour of the president's private office was a photograph of George H.W. Bush in his Yale baseball uniform, shaking Babe Ruth's hand. Good manners dictate that she not try to steal it for her baseball fanatic husband; she did not.
The invitation to tea had arrived bearing gold engraving and an American flag stamp (of course): "Mrs. Laura Bush requests the pleasure of your company at tea ... " and directed guests to the east entrance. A small accompanying card asked invitees to respond with their Social Security number and date of birth. Which, for an event honoring an etiquette expert, seems like rather poor manners: Isn't it impolite to ask a lady her age? ...
LAMPSHADES ARE THE NEW BLACK: Barneys New York, known for its irreverent window displays, has just installed thrift-store lampshades (moonlighting as hats and various accoutrements) in its Seattle store windows. "They're the lampshades you would walk by at a garage sale," says display manager Jodi Davis. "They're hideous. We'll take something like that and pair it with high fashion, and it looks great." But like so much high fashion, it's hard to pull off unless you're 6 feet tall, weigh 100 pounds and are made of plastic. ...
LADIES WHO LUNCH: Seattle-based Gourmondo Catering is used to, um, catering to celebrities, even when it comes to a simple boxed lunch. We hear that when the team from Martha Stewart Living comes to town, they request fresh tulips with their lunch orders — and they choose the color. "She's the only one who requests tulips for her boxed lunches," said Gourmondo co-owner Alissa Leinonen Gallagher. Even Oprah's people don't do that. But as long as we're being persnickety, we can't confirm it's Martha herself who is eating those gourmet panini sandwiches and petit chocolate cake — but either way, it appears the domestic doyenne is leading by example. ...
SPEAKING OF SANDWICHES, Jared Fogle — also known as "Jared from Subway" — made the rounds at Seattle-area schools while in town for the American Heart Association's Seattle Heart Walk. Jared, who famously lost 245 pounds by eating two Subway sandwiches a day, still eats there several times a week. Between talking to kids about how not to get fat, the still-slim Subway spokesman said, "I'm eating everything" in Seattle. Well, not everything. Not Quiznos. "Oh, heck no! You're not going to see me eating there, that's for sure." But Jared, have you ever tried it? Quiznos is toasty delicious. "No, don't say that. Boo." ...
CELEBRITY SIGHTINGS ROUNDUP: Jerry Seinfeld, looking youthful in jeans and a blazer, at Pacific Place ... Ashlee Simpson and boyfriend Pete Wentz at a lobster dinner prepared by Barolo owner Leo Varchetta at a downtown Seattle condo ... Tom Skerritt at Wild Ginger co-owner Rick Yoder's 50th birthday bash at Triple Door ... Former Supreme Court Justice Sandra Day O'Connor dining at the Met ... "Hotel fairies" in skimpy fairy costumes sprinkling good-luck fairy dust on guests at the Seattle Sheraton's 25th anniversary party, including musical guests Kool and The Gang ... Jared from Subway wearing dark sunglasses and a hat while eating at Quiznos. Just kidding.
Girl About Town appears every Sunday in Northwest Life. Pamela Sitt: 206-464-2376 or firstname.lastname@example.com
Copyright © 2007 The Seattle Times Company
general classifiedsGarage & estate sales
Furniture & home furnishings
just listed
Absolutely Adorable Tiny Yorkie Girl
ADOPTION: At-Home Mom Financially Secure Fa...
AKC Imperial Shih Tzu Puppies
More listings
- Seahawks are close to completing a stunning turnaround | Jerry Brewer
- Dr. Oz's facts: 4 out of 10 aren't true
- Attacking ISIS, from a U.S. aircraft carrier
- Bellingham-based Haggen plans to buy 146 stores
- Here's how professional decorators dress their home for the holidays | Northwest Living
- Packaged caramel apples linked to 5 deaths, ill Thurston County teen
- AP sources: Cops' killer angry at chokehold death
- After 10 years, few payoffs from Gates' 'Grand Challenges'
- Guest: A fragile peace in the aftermath of the Marysville Pilchuck shooting
- The Seahawks' Pete Carroll deserves to be in the coach-of-the-year conversation


text:
Video: Les Savy Fav - Let's Get Out Of HereWednesday, 10th November 2010 9:40AM
Here's a brand new video from Les Savy Fav for "Let's Get Out of Here" from their excellent new album Root For Ruin. Of course LSF have just been announced to be heading our way next year for the very first time - click HERE to read the announcement if you missed it.
your comments
Login here to leave your comment
related gigs
Tue, 1st FebLes Savy Fav
Kings Arms Tavern, Auckland
Wed, 2nd FebLes Savy Fav
The San Francisco Bath House, Wellington


text:
Game: Portal
Format: Flash
Portal? In 2D? In Flash!? Yes, it happened, and yes, it was great. Fantastic even.
The Flash version of Portal doesn't just prove that the medium can provide far more than generic point and click shooting galleries and delightfully messed up cartoons. No, the Flash version of Portal is all the evidence you need to show that 2D gaming is still capable of just as much cool stuff as 3D. In the hands of talented and devious games designers, that missing dimension doesn't hinder things. In just creates a whole new set of challenges and possibilities.
The fact that Portal works so well in 2D also says a lot about the genius of the original game's concept. In the same way that a good tune will work on any instrument, the simple but revelatory mechanic of Portal absolutely flies in 2D. All of the rules are the same. All of the features we love are present and correct. But everything's completely different. But exactly the same. And just as good.
We love this one, we really do.
RobTheBuilder - September 28, 2009 3:59 p.m.
RebornKusabi - February 10, 2009 4:17 a.m.
Showing 1-3 of 3 comments
Log in using Facebook to share comments, games, status update and other activity easily with your Facebook feed.


text:
Hi Everyone,
I got asked to make a 1st Birthday cake, matching cupcakes and a smash cake. Its my first time making a smash cake. I was wondering what you would charge for a smash cake? do you take in consideration the other items she is ordering?
Any suggestions please?
Thank you!
IMG_4244-2.JPG 210k .JPG file


text:
News & Events
August 20, 2014
Watch as construction crews transform campus for the upcoming academic year
August 20, 2014
Roughly 150 alumni from Cape Cod filled a dining room at The Club at New Seabury in Mashpee to hear the latest news from President Dana...
August 20, 2014
New facility will offer local residents many options in degree programs
August 14, 2014
Faculty pushes for EMT training program in wake of marathon bombing
August 13, 2014
Graduate students spend time in Jordanian refugee camps
August 12, 2014
Discusses importance of education for his nation, cites importance of BSU partnership
July 31, 2014
Bridge to Employment Program gives students opportunity to explore STEM areas
July 24, 2014
A dozen participants spend two weeks in classrooms, exploring the region, D.C. and more
July 17, 2014
Meagan Shapanus earns scholarship for her work with Hispanic/Latino communities
July 17, 2014
CASE offers Summer Science Academy for area middle school students
May 30, 2014
Alumnus Collin Estrada plays key role in university's Belize initiative
May 30, 2014
New program to help young people stay in school, find careers
May 30, 2014
English professor earns stay in Aspen to work on novel
May 27, 2014
Sgt. John MacLellan, '88, honored by President Obama
May 23, 2014
Governor visits BSU to celebrate achievements of ICE Program
May 17, 2014
Something to remember your days on campus
May 17, 2014
Undergraduate commencement celebrates achievements of 1,400 in first-ever split ceremony
May 17, 2014
Initial group of graduates from partnership with the Home for Little Wanderers celebrated
May 15, 2014
Graduate commencement celebrates achievements of 500
May 14, 2014
Alumna writes art book for students and teachers
March 6, 2013
Panelists discuss career options in athletic training, chiropractic medicine, occupational therapy and physical therapy. The event was...
February 27, 2013
Professor Henry Glassie of Indiana University-Bloomington delivered a lecture, "Tradition and Creativity in Turkey Today." The event was...
December 4, 2012
BCU's VP of Lending discusses establishing, maintaining good credit
November 29, 2012
Author discussed book, shared insight on Palestinian/Israeli conflict
November 21, 2012
Archaeologist tracks female embodiment, influence through medieval Icelandic textiles
November 21, 2012
A scholar and food writer discuss their books, research
November 15, 2012
Karen Thornber comes to campus as Asian Studies distinguished lecturer
November 14, 2012
Larry Spotted Crow Mann discusses history, performs music of Nipmuc tribe
October 25, 2012
Annual awards ceremony recognizes outstanding student essays
October 16, 2012
Panelists offer advice on scoring jobs in the field
BSU In the news
News Briefs
Administrator earns scholarship
Students present, compete at geography conference in N.H.
Forensic team earns several trophies
Professor to study 'permaculture'
Alumna Wins Art Award
Art Professor Selected


text:
we just had 4 new tires put on and had the shop go ahead and do a 4 wheel alignment to prevent premature wear on a brand new set of tires!!unfortately they found that the uppr control arms were loose,to the point they couldnt correctly align the front end.i have heard some horror stories of a "frozen" or siezed bolt in the pinch bar part of the assembly,ANY hints,tips,advice to help me get through this smoothly will be very much appreciated..and i send thanks to all.
View questions for:All Audi
A4 Quattro
1999 Audi A4 Quattro
Audi Q&AAsk Your Question
1999 Audi A4 Quattro Question: replacing upper control arms/passenger side
jos-quattro, 1.8L 4 Cylinder Turbo, Marion, NC, March 06, 2014, 22:20
1 Answer
Answer #1asksteevies March 07, 2014, 13:58Master
Yes there rite ,u gotta have it done ,it use to be expensive ,thats why people dumped Audi and just bought jettas ,Hondas ,etc.
When I did upper control arms it was 750.00$..
Answer Ranks
This week's top 10
|1 pushrod
|6 mobilemike
|2 ziptie12
|7 Leopsa
|3 CharlesAutomotive
|8 Randico
|4 globalhelper
|9 wrayauto
|5 stevieray1
|10 Flower Hill


text:
Choose from Three Options
$99 for a full set of eyelash extensions (a $275 value)
$119 for a full set of eyelash extensions with a fill (a $340 value)
$139 for a complete eye-makeover package (a $384 value)
- Full set of eyelash extensions with a fill
- Brow and lash tint
- Brow wax<p>
Enrapture Salon & Spa
The details are what matters at Enrapture Salon & Spa, which is why complimentary beverages, such as spiced tea and cucumber water, are offered to clients at the start of their appointment. Stylists then use a keen eye for detail—from studying face shapes to determining eye colors using a piece of broken-off rainbow—to transform manes with Organic Color Care System color, 100% human hair extensions, and thermal hair straightening techniques. Finally, a complimentary hand massage and Jane Iredale makeup application are included with every salon service.
I love the ambiance, the attitude, the truly inspired way they provide ideas to make the most of what nature gave meAhnalira K., Yelp, 5/13/13
Very attentive, very nice, definitely will be going back.Lauren M., Yelp, 10/23/12
"Had such a great experience here! The staff is awesome and will do your hair exactly as YOU like it :)"
"I can recommend Emily heartily...did a fabulous job on my partial foil & haircut : )"
"Great "team-work" & excellent cut/color!"
Silver Lake
10530 19th Ave SE
Ste 203
Everett, Washington 98208
425-338-1711Get Directions


text:
- 3 Comments
Nearly 480 five-star Amazon reviews on this set.
spend more on buying D size battery shells - not worth it.
^ You might as well just buy D cells. It uses them for a reason, so you don't have to change batteries very often.
On the other hand, keep in mind that 3 x D cells is 4.5V, close enough to 5V. You could just rig each one up with a leftover cell phone charger with an extra piece of wire soldered on to extend the length and unlike AC powered lights you don't have to worry about electrical codes when stringing low voltage DC.
yeah i rather have 3 D's in there than 10 AAA's
Already a member? Sign in below.
Registration takes seconds! Once registered you�ll have members only access to:
The best deals, product reviews, and giveaway announcements emailed directly to you!
Sign up now for the Ben's Bargains newsletter!
Thanks! You can also register an account with us to be eligible for Giveaway Entries, Deal Alerts, and Comments.


text:
KANSAS CITY, Mo. An estimated 750,000 hospitalized patients experience cardiac arrest and undergo CPR annually, and less than 30 percent of those leave the hospital alive.
In a paper published in the Jan. 3 issue of the New England Journal of Medicine, researchers quantified the impact of receiving a life-saving electrical shock (defibrillation) among hospitalized patients experiencing a form of cardiac arrest known as ventricular arrhythmia. They found that the chances of survival for hospitalized patients improve dramatically if defibrillation is administered within the expert-recommended two minutes following a cardiac arrest.
Analyzing data from the National Registry of Cardiopulmonary Resuscitation, the authors concluded that 30 percent of patients with cardiac arrest due to ventricular arrhythmia received life-saving defibrillation more than two minutes after initial recognition of their cardiac arrest, a delay that exceeds guidelines-based recommendations. The delayed defibrillation was linked to a significantly lower probability of survival to hospital discharge 22 percent vs. 39 percent when defibrillation wasnt delayedand a 26 percent lower likelihood among survivors of being discharged without major neurological impairment.
The findings also revealed certain hospital characteristics were associated with delayed defibrillation, including small hospital size (fewer than 250 beds); occurrence of cardiac arrest in hospitalized patients whose heart rhythm was not being constantly monitored in specialized units; and occurrence of cardiac arrest after-hours (i.e., nights and weekends).
While several prior studies have shown an association between defibrillation time and survival, these were relatively small studies that typically included patients whose arrest rhythms would not have benefited from defibrillation said lead study author Paul S. Chan, M.D, a cardiologist and researcher from Saint Lukes Mid Americ
|Contact: Kara Gavin
University of Michigan Health System


text:
Video: Watch Fulham score a couple of stunners in 4-0 thrashing of Sheffield Wednesday
Re-live all the action, goals and celebrations as the Cottagers silenced the Owls
Fulham FC is based in Fulham, and play their home games at Craven Cottage. Founded in 1879, the club are now playing in the Championship following relegation last season. Its nicknames are The Cottagers and The Whites.


text:
live ranking›
Kid vs. Kat Cast List
Items here include everything from Frank Welker to Rob Paulsen.
If you are wondering, "Who are the actors from Kid vs. Kat?" or "Who starred on Kid vs. Kat?" then this list will help you answer those questions.
In most cases you can click on the names of these popular Kid vs. Kat actors and actresses to find out more information about them. If you're looking for a particular Kid vs. Kat actor or actress, then type their name into the "search" bar to find them directly.
- 1
Billy West Fry, Skeets, Zoidberg
- 2
Brian Drummond Flanagan Boone, Kagerōmaru
- 3
Carter Jenkins Rick
- 4
Cathy Weseluck Spike
- 5
Chiara Zanni Petunia Pig
- 6
- 7
Erin Matthews Coop Burtonburger
- 8
Frank Welker Jerry Mouse, Nibbler, Uni the Unicorn
- 9
Grey DeLisle Azula, Vicky, Samantha "Sam" Manson
- 10
Jeff Bennett Prince Eric, Keswick, Kowalski
- 11
Kathleen Barr Ned Brachiosaurus
- 12
Kath Soucie Daisy Duck, Madeline Fenton, Minx
- 13
Kevin Michael Richardson Joker, Cleveland Brown, Jr, Dark Laser
- 14
Nancy Cartwright Bart Simpson, Ralph Wiggum, Billy
- 15open
- 16
Pamela Adlon Milo Oblong, Marcy Runkle, Dewey Duck
- 17
Rob Paulsen Jack Fenton, Box Ghost, Saber Rider
- 18open
- 19
Tabitha St. Germain Jenni Anderson, Baby Stygimoloch, Rarity
- 20
Tara Strong Timmy Turner, Twilight Sparkle, Ben Tennyson
- 21
Tom Kane Ultimos
- 22
Tom Kenny Ranger, Iron Man, SpongeBob SquarePants
- 23
Tress MacNeille Agnes Skinner, Daisy Duck, Arnold's Grandma
- 24
Trevor Devall Ryūkotsusei
- 25
- 26
Vincent Tong Gene Khan


text:
Playstation 3
LEGO Harry Potter: Years 5-7 Answers for Playstation 3Home / Playstation 3 /
Game Questions & Answers (Q&A) service lets you ask questions about video games for game consoles or PC games. So ask your LEGO Harry Potter: Years 5-7 question for Playstation 3 and get answers from real gamers or answer questions and share your insights and experience with the rest of the gaming community.
- Developer: Traveller's Tales
- Publisher: Warner Bros. Interactive Entertainment
- Genre: Action Adventure Fantasy
- Release Date: Nov 11, 2011
- ESRB: Everyone 10+
Question & Answers
What if? Trophy
I have killed all the harry potter varients but the achievement still have not popped what am i doing wrong? it is being done on player one also
Answer from: stewie
Have u used harry (albert runcorn)
Answer this QuestionAll Questions Ask a Question
Unanswered Questions
Invisibility extra
From: Legodud3
From: Legodud3
Total 0 Answers
Posted on: 10-26-2014
Posted on: 10-26-2014
How to defeat malfoy?
From: don
From: don
Total 0 Answers
Posted on: 03-24-2013
Posted on: 03-24-2013
Last shield inside the little shop
From: JasonB
From: JasonB
Total 0 Answers
Posted on: 02-09-2013
Posted on: 02-09-2013
Professor snaype
From: Snaype and harr
From: Snaype and harr
Total 0 Answers
Posted on: 08-18-2012
Posted on: 08-18-2012
Professor snape
From: Tyson
From: Tyson
Total 0 Answers
Posted on: 07-02-2012
Posted on: 07-02-2012
Here lies a free elf and to be continued
From: Mduke84
From: Mduke84
Total 0 Answers
Posted on: 03-11-2012
Posted on: 03-11-2012
Videos You May Like...
LEGO Harry Potter: Years 5-7 - Halloween Trailer
- Aug 21, 2014, Views: 114
LEGO Harry Potter: Years 5-7 - Launch Trailer
- Aug 21, 2014, Views: 39
LEGO Harry Potter: Years 5-7 - Locations Gameplay
- Aug 21, 2014, Views: 36
View All Videos
LEGO Harry Potter: Years 5-7 - Spells Gameplay
- Aug 21, 2014, Views: 37
Game Related Options
New Released Games
- Gundam Breaker 2, (PS3)
- Nobunaga No Yabou Online: Kakusei No Shou, (PS3)
- Guilty Gear Xrd -SIGN-, (PS3)
- Super Mega Baseball, (PS3)
- Hajime No Ippo: The Fighting!, (PS3)
- JOYSOUND.TV Plus, (PS3)
- Nobunaga No Yabou: Souzou With Power-Up Kit, (PS3)
- Shining Resonance, (PS3)
- Kamen Rider: SummonRide, (PS3)
Popular Playstation 3 Games
Popular Videos
- Kim Kardashian: Hollywood - Gameplay, (iPhone-iPod)
- Episode: Choose Your Story - Gameplay, (iPhone-iPod)
- How To Train Your Dragon 2 - Ready To Fly Trailer, (Wii)
- The Settlers - Kingdoms Of Anteria - Announcement Trailer, (PC)
- Entwined - Quick Look Trailer, (PS3)
- Blue Estate - Official Launch Trailer, (PS4)
- Goat Commando 3D Simulator - Gameplay, (iPhone-iPod)
- Munin - Official Launch Trailer, (iPad)


text:
December 21, 2014
JANESVILLE (WIFR) -- A Janesville man is under arrested after allegedly driving drunk for the 4th time.
34 year old Walter Pitcher was pulled over just after midnight on Friday. When an officer approached Pitcher's car, he noticed the smell of alcohol coming from his car, as well as Pitcher's slurred speech.
After Pitcher failed a field sobriety test, it was discovered he had 3 prior OWI convictions as well as a revoked driver's license for one of those previous convictions.
Pitcher's blood alcohol level was .16. Pitcher is being held at the Rock County Jail until his court appearance.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


text:
My Account
item(s) in cart
Costa Del Mar Mesh Trucker Cap
Key Features
Cotton front panels; breathable mesh back panels
Garment wash for softness, comfort, broken-in look
Secure Velcro closure in back for easy on and off
Six-panel cosntruction for long-wearing durability
Our Price $19.99
Availability: Sold Out
- Please note: This item can only be shipped to U.S. addresses.
detailsback to top
Product DescriptionThis six-panel trucker cap combines cotton panels in front and mesh in the back. A garment-washed finish gives the cap a soft, comfortable feel and a broken-in look. A Velcro closure in back allows for a secure fit and quick release. Imported.
product reviewsback to top
Reviewed by 1 customer
- Comfortable
- Durable
Best Uses
- Casual Wear
Comments about Costa Del Mar Mesh Trucker Cap:
Good durable product, would buy it if it had more colors.
- Sizing:
- Feels true to size
- Was this a gift?:
- No


text:
Smarter Decisions,
Better Care
UpToDate synthesizes the most recent medical information into evidence-based practical recommendations clinicians trust to make the right point-of-care decisions.
Choose from the list below to learn more about subscriptions for a:
Subscribers log in here
Related articles
Related Searches
Topic Outline
Medications can induce esophageal abnormalities via both systemic effects and by causing direct esophageal mucosal injury. Systemic effects of medications that can result in esophagitis include gastroesophageal reflux and medication-induced infectious complications.
This topic will review medication-induced esophagitis from direct esophageal mucosal injury. The pathophysiology of reflux esophagitis and the clinical manifestations, diagnosis, and management of other causes of esophagitis are discussed in detail, separately. (See "Pathophysiology of reflux esophagitis" and "Clinical manifestations and diagnosis of eosinophilic esophagitis" and "Overview of dysphagia in adults".)
The estimated incidence of medication-induced esophagitis is 3.9 per 100,000 population per year with a mean age at diagnosis of 41.5 years [1,2]. Although medication-induced esophagitis has a higher prevalence in women, this may be due to a higher likelihood of women being treated with culprit medications rather than an underlying difference in susceptibility to medication-induced esophageal injury. Medication-induced esophagitis usually occurs at anatomical sites of esophageal narrowing. Of these, the most common site is near the level of the aortic arch (76 percent) due to extrinsic compression and physiologic reduction in the amplitude of the esophageal peristaltic wave [1].
Medications that cause direct esophageal mucosal injury include the following.
Antibiotics — Tetracycline, doxycycline, and clindamycin have been associated with esophagitis due to their direct irritant effect. (See 'Pathogenesis' below.)
Subscribers log in here


text:
Local Journos Remember Tony Tranfa
LA Observed reported yesterday on the death of Tony Tranfa, the 49-year-old online editor at the Daily Breeze.
His friends and co-workers were of course saddened by the news. But when they talked about Tony with FBLA, the first things to come to mind were the things that brought smiles to their faces.
Here are a few of those:


text:
SB Researchers Predict Material 'Denser than Diamond'
New forms of carbon break the record of density and predicted to possess tunable electronic properties
Stony Brook University graduate student Qiang Zhu, together with Professor of Geosciences and Physics, Artem R. Oganov, postdoc Andriy O. Lyakhov and their colleagues from the University de Oviedo in Spain, have predicted three new forms of carbon, the findings of which were published in a paper entitled "Denser than diamond: Ab initio search for superdense carbon allotropes," in the June 7, 2011 online edition of Physical Review B. So far, each new found modification of carbon resulted in a scientific, technological revolution – the same could happen now, if scientists can find a way to synthesize these new forms of carbon.
Elemental carbon possesses a unique range of structures and properties – from ultrasoft graphite to superhard diamond, including elusive carbines, beautifully symmetric fullerenes, carbon nanotubes, and the recently established new form, M-carbon (the structure of which was predicted by Oganov in 2006). Properties of all these modifications of carbon are so interesting and so tunable that two Nobel prizes were awarded recently for their studies (the 1996 Chemistry and 2010 Physics awards).
Graphene is the densest two-dimensional material, with unique mechanical and electronic properties and having some electrons moving with near-light velocities and behaving as if they had zero mass. Diamond has set several records – it is not only the hardest known material, but also has denser packing of atoms than any other known three-dimensional material. When doped by boron, diamond displays superconductivity and is the only known material simultaneously displaying superhardness and superconductivity.
Now Zhu, Oganov, and their colleagues propose three new structures of carbon, which should be more than 3% denser than diamond. Greater density means that electrons should have a higher kinetic energy (that is, move faster). Calculations of Zhu et al. show that the new modifications are almost as hard as diamond, but do not exceed its hardness. Their electronic properties are very diverse, with the band gap ranging from 3.0 eV to 7.3 eV. Band gap is the minimum separation in energy between occupied and unoccupied electronic orbitals and is the most important characteristic of the electronic structure of materials. Such a wide range of band gaps implies the possibility of tuning the electronic properties. The band gap of 7.3 eV predicted for the tP12 modification is the largest value for all forms of carbon.
Other interesting properties include ultralow compressibility – when subjected to pressure, the new forms of carbon will contract less than most materials (even slightly less than diamond, the current record holder). They have higher refractive indices and stronger light dispersion than diamond – which means better brilliance and color effects than those displayed by diamond. "Carbon is an inexhaustible element in its chemical diversity and in the multitude of its physical applications", says Professor Oganov. "If these predicted forms of carbon can be synthesized, they may find important technological roles". Researchers believe that the new forms of carbon, thanks to their high densities, could be synthesized by shock compression of low-density modifications, or by directed growth on substrate.
Yi-Xian Qin of Biomedical Engineering Elected Into American Institute for Medical and Biological Engineering's (AIMBE) College of Fellows
Dr. Yi-Xian Qin recognized for his work in orthopedic biomechanics
Yi-Xian Qin, Ph.D., Professor of Biomedical Engineering, Orthopaedics, and Biophysics at Stony Brook University, has been elected into the American Institute for Medical and Biological Engineering's (AIMBE) College of Fellows. Recipients of this honor, considered one of the highest in the biomedical engineering discipline, are chosen for their outstanding achievements in medical and biological engineering.
AIMBE states that Dr. Qin was elected into the College of Fellows "for his work in orthopedic biomechanics, which has provided unique insights into the mechanical control of bone repair and remodeling, as well as noninvasive diagnosis of bone diseases."
Dr. Qin, Director of Stony Brook's Orthopaedic Bioengineering Research Laboratory, has developed a new form of ultrasound that assesses multiple parameters of hard tissue like bone. This technology, called SCAN (Scanning Confocal Acoustic Navigation) is more advanced than existing ultrasound in that it assesses bone parameters beyond mineral density.
"SCAN enables researchers to identify weak regions in bone and thus is an emerging technology that may assist in bone healing and prediction of fractures," says Dr. Qin. "The technology also has the potential as a diagnostic for the prediction of early bone loss, a hallmark of osteoporosis, a disease that affects millions worldwide."
The 2011 AIMBE election of Fellows led to 79 researchers nationwide named as Fellows. A non-profit organization representing 50,000 individuals, AIMBE was founded in 1991 to provide leadership and advocacy in medical and biological engineering for the benefit of society. The College of Fellows is comprised of the top 2 percent of medical and biological engineers.
Thomas C. Skalak, AIMBE President and Vice President for Research at the University of Virginia, called the 2011 elected Fellows talented individuals who "truly enhance the fabric of our society."
Recognized for their contributions in teaching, research, and innovation, Fellows include leaders in industry as entrepreneurs, directors of research and development, and respected professors as well as heads of engineering and medical schools nationwide.
Dr. Qin received his Ph.D. in Mechanical Engineering from Stony Brook University in 1997. He earned an M.S. in Mechanical Engineering in 1993, also from Stony Brook University. Previous to that he completed his undergraduate education in Shanghai, China, in 1982.
President Stanley's Statement on the NYSUNY 2020 Initiative
President Samuel L. Stanley Jr., MD, today applauded Governor Andrew Cuomo and SUNY Chancellor Nancy Zimpher's announcement of the NYSUNY 2020 Program.
"NYSUNY 2020 is exciting for SUNY, for Stony Brook University and for our region," said President Stanley. "We applaud Governor Cuomo for his leadership and Chancellor Nancy Zimpher as well, for her commitment and support; together they are advancing the role of SUNY's research institutions and the future of the State's prospects for economic development.
"The Governor's plan calls for an infusion of capital dollars for construction keyed to research and requires long term economic and academic plans which Stony Brook has finalized recently and will promptly submit for consideration," said Dr. Stanley. "This visionary plan presents the opportunity for Stony Brook to increase tuition resulting in additional operating revenue while helping us generate the necessary private funding that will enable us to populate new facilities with leading research faculty and staff, and provide opportunities for the most exceptional students. In so doing, the plan will further our mission of education, research, and discovery of cutting edge technology and new medical treatments.
"As a top-tier research university and member of the prestigious AAU, Stony Brook University is poised to be the engine of a dynamic, interconnected and entrepreneurial regional network for economic innovation and will help NY excel under NYSUNY 2020. SBU accounts for 97% of all SUNY royalties; its average royalty income is $10 million – $15 million per year, and SBU's gross royalty income for FY 09 was $17,220,322.57. In addition, SBU researchers have filed approximately 1,400 invention disclosures and have been awarded more than 800 patents.
"It is exceptional that the Governor and the Chancellor have recognized the track record of Stony Brook and the other University Centers for their leadership and ability to have a positive and productive impact on regional economic development. We look forward to working with the entire Long Island delegation, the Long Island Association and other key business leaders on Long Island to get their full support, which is critical for NYSUNY 2020 to succeed.
News Release from Gov. Cuomo's Office: GOVERNOR CUOMO AND SUNY CHANCELLOR ZIMPHER UNVEIL GROUNDBREAKING "NYSUNY 2020″ PROGRAM
New Research Explains Why More Species Live in the Amazon Rainforests
Evolution of Treefrogs Sheds Light on the Mystery of High Amazonian Diversity
For more than two hundred years, the question of why there are more species in the tropics has been a biological enigma. A particularly perplexing aspect is why so many species live together in a small area in the tropics, especially at some sites in the rainforests of the Amazon Basin in South America.
New research on the evolution and ecology of treefrogs, to be published online this month in the journal "Ecology Letters," sheds new light on the puzzle. The patterns found in treefrogs may also help to explain the high species richness of other groups of organisms—such as trees, birds and insects—in the Amazon rainforests.
The article, entitled "Phylogenetic Origins of Local-Scale Diversity Patterns and the Causes of Amazonian Megadiversity," will be published online at http://www.wiley.com/bw/journal.asp?ref=1461-023x.
"Treefrogs are a particularly important group to study for understanding amphibian diversity, because they can make up nearly half of all amphibian species in some rainforest sites," says lead author John J. Wiens, an Associate Professor in the Department of Ecology and Evolution at Stony Brook University. "Treefrogs also offer a striking example of the high local-scale biodiversity in the Amazon. At some sites in the Amazon rainforest, there are more treefrog species in a small area than there are across all of North America or Europe."
The researchers compiled data on the number of treefrog species at 123 sites around the world and analyzed the data with a new evolutionary tree (based on DNA sequence data) for 360 treefrog species. They discovered that the richness of treefrog species in the Amazon rainforest sites is not explained by wet, tropical climatic conditions alone.
"In fact, we found that many tropical rainforest sites that are outside the Amazon Basin have no more species than do some sites in temperate North America," explains Dr. Wiens.
Instead, the researchers discovered that the high biodiversity of Amazonian sites is related to different groups of treefrogs occurring together in the Amazon Basin for more than 60 million years—since before most dinosaurs became extinct. In contrast, those sites in tropical rainforests that have relatively few treefrog species are in areas that were colonized by treefrogs much more recently.
These results also have important implications for humans. "The results suggest that the incredible biodiversity of amphibians in some sites in the Amazon Basin took more than 50 million years to develop," says Dr. Wiens. "If the Amazon rainforests are destroyed and the amphibian species are driven to extinction by human activities in the next few decades, it may take tens of millions of years for this incredible level of biodiversity to ever return."
SUNY STEM Conference
SUNY Office of Diversity and Educational Equity
November 3-4, 2011, the Albany Crown Plaza, Albany, New York
Several SUNY Institutions are New York State and national leaders in enhancing the participation of underrepresented students in STEM (science, technology, engineering and mathematics). Much of the diversity work is done with the support of New York State, federal, business/industry, and private foundation support.
The SUNY STEM conference will showcase successful programs dedicated to educating diverse students in SUNY and beyond. The conference will include workshops and posters on best practices in diversity in STEM education–as well as two keynote speakers: Dr. Irving McPhail, President and CEO, National Action Council for Minorities in Engineering, Inc. (NACME), and Dr. Lorelle Espinosa, Director of Policy and Strategic Initiatives, Institute for Higher Education Policy (IHEP).
Participants will have the opportunity to explore partnerships that include schools and higher education (SUNY and beyond), business/industry, and government. The conference is being organized by the SUNY Office of Diversity and Educational Equity (ODEE) – led by Mr. Carlos Medina, Associate Provost/Associate Vice Chancellor for ODEE. The co-chairs of the conference are Dr. David L. Ferguson, Distinguished Service Professor and Chair, Department of Technology and Society in the College of Engineering and Applied Sciences at Stony Brook University, and Dr. Letitia Thomas, Assistant Vice Provost and Director of the Center for Academic Development Services in the Cora P. Maloney College at the University at Buffalo.
Call for Proposals:
There will be two types of opportunities for presentations: workshops and posters. All confirmed workshop presenters should also be prepared to share a poster of their workshop. Submissions for "poster session only" proposals are also welcomed. The poster session will provide an opportunity for all conference attendees to be exposed to the wide variety of programs that exist across SUNY.
We seek 500-1,000-word proposals that demonstrate effective efforts at increasing the number of diverse students for STEM disciplines and professions. Proposals that incorporate partnerships with schools or industry with demonstrated success in increasing access, retention and graduation of historically underrepresented student populations in STEM majors are particularly encouraged.
Workshops will be approximately 75 minutes in length. Presentation proposals that outline one or more of the following strands are invited.
- Recruiting – what are the most effective methods for recruiting diverse students into the STEM disciplines?
- Retaining – what are the best practices and strategies for acquiring funding for retaining diverse students in the STEM disciplines?
- Releasing – how do we best prepare diverse students for their futures, including but not limited to, graduate schools, professional schools, or their careers?
- Partnering – what programs model the best practices between academia and some other group (for example: an outside industry, such as technology companies, businesses, or post-graduate and professional training programs; another school, such as a high school, community college, college/university, or graduate school) in the recruiting, retaining or releasing of diverse students in the STEM disciplines?
Posters are encouraged if they include elements of any of the strands discussed above. Posters will be on display throughout the meeting, with a specific time set aside for their presentation and discussion.
Deadline to submit proposals is June 1, 2011.
The conference committee strongly encourages the participation of administrators, faculty, staff, business/industry professionals, and governmental leaders. Visit www.suny.edu/provost/stemfor further information.
Registration is expected to open in July 2011.
Scientists Can Track Origin of Shark Fins Using 'Zip Codes' In Their DNA
Studies show that coastal sharks have 'DNA zip codes' that can reveal where they were born; underscores potential of DNA testing to monitor fin trade
An international team of scientists, led by the Institute for Ocean Conservation Science at Stony Brook University, has used DNA to determine that groups of dusky sharks (Carcharhinus obscurus) and copper sharks (Carcharhinus brachyurus) living in different coastal regions across the globe are separate populations of each species. Both are large apex predators that are heavily exploited for the shark fin trade, which claims tens of millions of animals every year to produce the Asian delicacy, shark fin soup. Many of these species are declining as a result of this fishing pressure for their fins.
The dusky shark is classified as "Endangered" in the Western Atlantic by the International Union for Conservation of Nature as its population is below 20 percent of what it was two decades ago. These new studies show that the genetic differences among populations of these sharks are large enough for scientists to be able to track the actual origin of the fins on sale in Asian markets, enabling better regional monitoring and management of these threatened predators.
These research findings appear in two scientific articles. "Global phylogeography of the dusky shark, Carcharhinus obscurus: implications for fisheries management and monitoring the shark fin trade," has been published online in the journal Endangered Species Research. "Phylogeography of the copper shark (Carcharhinus brachyurus) in the southern hemisphere: implications for the conservation of a coastal apex predator" will soon be published in the journal Marine and Freshwater Research. The primary objective of these studies was to identify any genetic differences among regional groups of dusky and copper sharks and establish how many distinct populations there are. The second objective was to determine if these population differences were great enough to allow scientists to reconstruct their contributions to fin trade in the future. Like many large sharks, these species have a wide distribution around the globe but are tied to coastal areas for reproduction.
"By analyzing part of the genome that is inherited solely through the mother, we were able to detect differences between sharks living along different continents – in effect, their DNA zip codes," said Dr. Demian Chapman, leader of the research team and assistant director of science of the Institute for Ocean Conservation Science. "This research shows that adult females faithfully give birth along the continental region where they were born. If fished too much, the population will collapse, and it is extremely unlikely that it will be replenished from immigration of sharks from another region."
This is precisely what has happened along the U.S. Eastern Seaboard, where the once common dusky shark is now rare and a species of concern for listing under the Endangered Species Act. At one time, these animals were common in ocean waters off the United States; however, a recent stock assessment of the sharks along the U.S. East Coast and in the Gulf of Mexico showed an 80 percent decline even though they have been protected since 2000. The recovery of the species is extremely slow because the average age of maturity is 20 years, its reproductive cycle only occurs every three years – including a two-year pregnancy – and its litter size is relatively small (three to 14 offspring).
"Here in the United States, it took only a few decades to nearly wipe out our dusky sharks, and it will probably take a few centuries for their stocks to be replenished," said Martin Benavides, lead author of both studies and research assistant at the Institute for Ocean Conservation Science. "Our results dash any hopes that dusky sharks from other areas of the world will replenish the depleted U.S. stock. The sight of a dusky shark swimming off our shores will be a rare experience for generations to come."
"We know very little about the shark fin trade, but by using DNA-zip coding we can identify source populations that are contributing most to the trade, and prioritize them for management," added Dr. Chapman. "We, therefore, really need to establish sampling programs of fins on their way to Asia or in the markets to regulate the global trade before many more populations suffer the fate of the dusky shark in the United States."
For years, it was difficult to determine the origin of these fins and whether they were from threatened species. A study by Dr. Chapman, which was published in 2009, Chapman(1) used DNA testing to trace scalloped hammerhead shark fins from the Hong Kong market all the way back to the sharks' geographic origin and found many came from collapsed Western Atlantic populations. These new research results demonstrate that this type of testing also can be used to trace the origins of the fins of dusky and copper sharks.
"As apex predators at the top of marine food webs, it is essential for ocean health that we take steps, such as monitoring and regulating the fin trade, to protect these large sharks," said Dr. Ellen K. Pikitch, executive director of the Institute for Ocean Conservation Science.
Both research projects were conducted by a collaborative international team of scientists from the United States, Australia, South America, Asia, New Zealand and southern Africa. The scientists collectively analyzed part of the mitochondrial DNA in nearly 400 sharks sampled from all over the globe.
This research was funded by The Pew Charitable Trusts through a grant to the Institute for Ocean Conservation Science at Stony Brook University. Sequence data were collected in the Field Museum's Pritzker Laboratory for Molecular Systematics and Evolution, operated with support from the Pritzker Foundation. Additional sequence data were collected at the Guy Harvey Research Institute with operational funds and a grant from the Save Our Seas Foundation. Funding was also provided by the Turner Fellowship Program and the Tinker Foundation.
For more information on "Global phylogeography of the dusky shark, Carcharhinus obscurus: implications for fisheries management and monitoring the shark fin trade," visit: http://www.int-res.com/abstracts/esr/v14/n1/p13-22/.
For more information on "Phylogeography of the copper shark (Carcharhinus brachyurus) in the southern hemisphere: implications for the conservation of a coastal apex predator," visit: http://www.publish.csiro.au/view/journals/dsp_journals_pip_abstract.cfm?nid=127&ver=3&pip=MF10236
The Institute for Ocean Conservation Science at Stony Brook University is dedicated to advancing ocean conservation through science. The Institute transforms real-world policy while pursuing serious science, both of which are essential for ocean health. For more information, go to www.oceanconservationscience.org.
(1) Chapman DD, Pinhal D, Shivji MS (2009); "Tracking the fin trade: genetic stock identification in Western Atlantic scalloped hammerhead sharks (Sphyrna lewini)," Endangered Species Research.
URECA Researcher of the Month: James Pastore
This month's featured student is James Pastore, a University Scholars junior majoring in chemistry who presented a poster at the Sigma Xi regional northeast conference (April 9, CEWIT) held at Stony Brook for the first time; and at URECA's campus-wide undergraduate research Celebration (April 27, SAC). James has been working since summer 2009 under the mentorship of Drs. Clare Grey and Lin-Shu Du in the Grey group, a trans-Atlantic research group linking Cambridge, England and Stony Brook, NY. Through the lab, he collaborates as a team member of the Energy Frontier Research Center (EFRC) and the Northeastern Center for Chemical Energy Storage (NECCES) — a multi-institutional, DOE-funded effort being led by Stony Brook University, and including as partners Rutgers University, MIT, Binghamton University, Lawrence Berkeley National Laboratory, Argonne National Laboratory, Brookhaven National Laboratory, the University of Michigan, and the University of California at San Diego.
James's project focuses on the conversion mechanism of metal fluoride nano-composites as positive electrode materials in lithium ion batteries. He is the only undergraduate in the Grey group, and has had to undergo a lot of training to perform complex NMR experiments – assembling coin cells with electrode materials in a glove box, learning how to process NMR and XRD data. As part of the research, he also works with collaborators at Brookhaven National Laboratory (BNL) to interpret data and confirm experimental results.
Last summer, James presented at the 15th International Meeting on Lithium Batteries in Montreal, Canada (June, 2010). James attended Sachem High School East, Farmingville, NY; his long term plans are to pursue graduate studies in materials chemistry.
For the full interview/feature, please go to: http://www.stonybrook.edu/ureca/researcher-month.shtml
Provost's Lecture Series – Professors and Imagination: Mastering Mental Imagery to Improve Teaching/Writing and Reveal Hidden Genius
Friday, May 13, 4:00 pm, Wang Center, Room 201
Robert Boice, Emeritus Professor of Psychology at Stony Brook University, and world-renowned author, is notable for his studies in faculty development and progress. Having received numerous awards in teaching, he also has published several books and more than 200 published articles. Some of his works include: Professors as Writers: A Self-Help Guide to Productive Writing, Procrastination and Blocking, and Advice for New Faculty Members. His work is highly regarded for its practical use and worthy guidance for new faculty. Boice is currently making final revisions on his forthcoming book, tentatively titled Imagination and the Professor, drawn from his current research on building higher minds by way of learned skills of imagination. His distinguished career has been dedicated to counseling new faculty on balancing their research work and classroom instruction. The focus of much of his work has been with helping faculty to overcome their writing problems so that they are able to turn their attention to their students and, therefore, become effective educators. Co-sponsored by Teaching Learning + Technology.
BME Professors Awarded NIH Grant for Research
Helmut Strey, Associate Professor of Biomedical Engineering, and Eric Brouzes, Research Assistant Professor of Biomedical Engineering, have been awarded a National Institutes of Health (NIH) grant for their research proposal, "Microfluidics for Single Cell Genomics." This grant will bring in approximately $450K during its two-year funding period, and complements the $97K bioscience technology development proposal they recently received from the Center for Biotechnology for their microfluidics technology.
"Our NIH research grant is funding the development of high-throughput microfluidics used to measure gene expression in single cells," said Strey. "This new approach has the potential to revolutionize how gene expression analysis is done."
"This research is a wonderful example of science and technology development at the convergence of biology and engineering, with terrific potential to improve our ability to identify those at risk of disease or the efficacy of new treatments," said Clinton Rubin, Chair and Distinguished Professor of Biomedical Engineering, and Director of the Center for Biotechnology at Stony Brook University. "Helmut and Eric are at the cutting edge of biomedical diagnostics, and we are all very excited about seeing this science translate to improve healthcare. This is great for Stony Brook, and great for New York."
Current gene expression analysis techniques are often limited because they combine the gene expression data of large cell populations and therefore miss the critical gene information expressed in single cells. This new single cell gene expression analysis allows for a better understanding of the individual cellular components of different groups of cells (tumors, brain tissue, etc.) and how genes in individual cells play a role during stem cell differentiation.
This new approach can be used by both researchers and clinicians. For example, it can be used to identify a single circulating tumor cell out of a billion cells present in the blood. Such an approach could lead to methods for early cancer diagnostics and cancer treatment monitoring.
Earthstock 2011: April 25-29
This week-long, campus-wide event, is free and open to the public. Environmental organizations, participants with an earth-friendly message, and local schools will celebrate on the Academic Mall, Friday, April 29. Stony Brook University is at the vanguard of the sustainability movement. Our commitment to a green future is evident everywhere on our 1,400 acres: from reducing our carbon footprint, to advocating recycling and using recycled materials whenever possible, to promoting alternatively fueled transportation. Check out the link, below, for Program Highlights.
Stony Brook University And Rutgers University Awarded National Science Foundation Grant For New Research Center
New Designation Brings Together Academics and Industry for Solving Data Collection and Analysis Challenges
The National Science Foundation has designated the Center for Dynamic Data Analytics (CDDA)—a partnership between Stony Brook University and Rutgers University—as a new Industry/University Cooperative Research Center (I/UCRC). The CDDA, based at Stony Brook's Center of Excellence in Wireless and Information Technology (CEWIT) will have a base budget exceeding $2M over the initial five year period. It will unite academics and industry in an effort to improve IT technology and its relevance in the business world. The focus will be on innovative research and applications in the emerging field of dynamic data analysis based on the collaborative efforts between the two Universities and the member companies.
The Stony Brook CDDA's corporate partners include CA Technologies, Northrop Grumman Corporation, SAP, Siemens, VJ Technologies, Softheon, Future Tech, Intrigma, DrChrono, Reveal Analytics, and General Sentiment. Additional businesses in the process of joining include IBM, Verizon, JP Morgan, Siemens, Applied Vision, FalconStor, Fatwire, Language Mate, XSB and Adobe.
"Our mission is to advance our knowledge on how to analyze and visualize massive, complex, multi-dimensional and multi-scale dynamic data," explains Principal Investigator Arie E. Kaufman, Distinguished Professor and Chair of the Computer Science Department and Chief Scientist of CEWIT at Stony Brook University. "The end result will be novel science, algorithms, systems and applications that transform chaos (due to the size of the data) into knowledge."
"CA Technologies is an IT management software and solutions company with expertise across all IT environments—from mainframe and physical, to virtual and cloud," says Russ Artzt Vice Chairman of CA Technologies, who serves as the Chairman of CEWIT Advisory Board. "CA manages and secures IT environments and enables customers to deliver more flexible IT services [and] as such CA is interested in dynamic and large data analytics and specifically interested in collaborating with the Stony Brook CEWIT on data experimental and analytics. The CDDA and the associated NSF funding will perfectly complement these activities."
The team of researchers from Stony Brook University and Rutgers University are experts in data analysis and visualization and have a long history of collaboration, while the corporate partners are leaders in their respective fields. "The center will close the essential loop between science and applications that is equally lacking between computer science research and IT development," notes Professor Kaufman. "The algorithm and system design will be tested, validated, and improved based on the close collaboration and research between the two universities and industry. This cycle of design, testing and improvement can only be accomplished through a close University-Industry collaboration and is especially significant in this situation because of the complexity of the data and the absence of relevant algorithms and systems."
"My colleagues Dorin Comaniciu, Kevin Zhou and Gareth Funka-Lea attended the CDDA planning meeting [at CEWIT] in January 2010, and are excited at the potential for CDDA to drive important innovations in data analytics," says Silvano Dall'Asta, Chief Financial Officer of Siemens.
In addition to advancing the science of dynamic data analytics, the CDDA will also accelerate its transfer to industry by working closely with its business partners in the definition and prioritization of projects to be pursued by the Center and will seek involvement from world renowned faculty and excellent students.
"Adobe Systems Inc. is delighted to participate as an industry partner in the IUCRC Center for Dynamic Data Analytics," says Jue Wang, Senior Research Scientist at Adobe. "The proposed scope of work around computer vision, computer graphics, context aware computing and distributed processing are extremely relevant to portfolios Adobe is building in digital media authoring and publishing solutions. Additionally, the goal of the Center to apply these novel data analytic approaches to healthcare, entertainment, environmental monitoring, and computer networks aligns with our mission of enabling new products and services in these industries."
Zhen Wen of the IBM T.J. Watson Research Center in Hawthorne, New York, says, "The proposed scope of work around large-scale, distributed data processing and mining is extremely relevant to IBM's portfolios in smarter planet solutions."
Dall'Asta, of Siemens, notes, "We fully support the Center's primary goal of accelerating both our understanding of the fundamentals of dynamic data analytics, and the transfer of these fundamentals into industry solutions."
"Northrop Grumman Corporation is pleased to participate in the proposed center and is interested in the general area of dynamic data analytics and more specifically in multivariate analytics, multi-dimensional data visualization, advanced human/machine interfaces for managing multi-dimensional data," says Lenny Poveromo, Director of Strategic University Alliances for Northrop Grumman.
"Our research will transform traditional research and significantly advance the computer science curriculum by improving the applications taught in our classes as well as having our industry partners lecture on the problems faced by industry," notes Professor Kaufman. "Our students will spend time with our industrial affiliates as research assistants and through internships, and will thus improve their skills and design more sound and improved algorithms."
The specific topics to be addressed by the Center are an emerging class of problems that are becoming increasingly important in many scientific and industrial areas, including computer science (e.g. cloud computing), biology, security, linguistics and the environmental sciences—all of which are confronted with analytics of massive and dynamic data. Ultimately, this endeavor will lead to new product development by the industrial partners in the area of dynamic data analytics. "The CDDA will transform traditional research in computer science and will have far-reaching consequences for both industry and homeland security," notes Professor Kaufman.
Kenneth Kaushansky Elected to Council Of the Association of American Physicians
Kenneth Kaushansky, M.D., MACP, Senior Vice President, Health Sciences and Dean, School of Medicine at Stony Brook University, has been elected as a Council Member of the Association of American Physicians (AAP). Part of the governing body of the AAP, the 10-member Council oversees the annual membership nomination process of physician-scientists and other medical researchers nationwide who have helped advance medicine through scientific discovery. Officially elected a Council member on March 25, Dr. Kaushansky has been a member of the AAP since 1998.
A physician-scientist and leading hematologist, Dr. Kaushansky has conducted seminal research on the molecular biology of blood cell production. His team has cloned several of the genes important in the growth and differentiation of blood cells, including thrombopoietin, a key regulator of stem cell and platelet production. He is an accomplished clinician, and he has been a champion of the need to train more physician-scientists who can bridge the gap between the laboratory and the clinical arena, translating research discoveries into improved treatments and technologies for the prevention, diagnosis and management of disease.
Dr. Kaushansky's laboratory work has led to several significant discoveries, for which he received the Dameshek Award from the American Society of Hematology, awarded annually to the scientist who has provided the most seminal insight into the Pathophysiology of hematological disorders, and the Outstanding Investigator Award from the American Society for Medical Research, the most prestigious award of the Society.
Dr. Kaushansky earned his B.S. and M.D. degrees from the University of California, Los Angeles, and completed his Internal Medicine Internship, Residency and Chief Medical Residency, and Fellowship in Hematology at the University of Washington. He joined the faculty at the University of Washington as an Assistant Professor in 1987, was promoted to Associate Professor in 1991 and to Professor in 1995. Following his service as Hematology Section Chief at the University of Washington Medical Center, Dr. Kaushansky was named Helen M. Ranney Professor and Chair of the Department of Medicine at UC San Diego in February 2002.
He is a past-president of the American Society for Clinical Investigation (2004 – 2005), the Western Society for Clinical Investigation (1998 – 1999) and the American Society of Hematology (ASH; 2007-2008). He also served a five-year term as Editor-in-Chief of the journal Blood (1998-2002) and has served as a major reviewer for the NIH, the Howard Hughes Medical Institute and many major scientific periodicals.
Dr. Kaushansky has also been recognized for his scientific, educational and clinical contributions by election as a Master of the American College of Physicians, and to several honor societies and organizations, including the AAP, the American Society for Clinical Investigation, the Institute of Medicine of the National Academies of Science and the American Academy of Arts and Sciences.
The Association of American Physicians is a nonprofit, professional organization founded in 1885 by seven physicians, including Dr. William Osler, for "the advancement of scientific and practical medicine." Now, the Association is composed of over 1300 active members and approximately 600 emeritus and honorary members from the United States, Canada and other countries. The goals of its members include the pursuit of medical knowledge, and the advancement through experimentation and discovery of basic and clinical science and their application to clinical medicine. Each year, individuals having attained excellence in achieving these goals, are recognized by nomination for membership by the Council of the Association. Their election gives them the opportunity to share their scientific discoveries and contributions with their colleagues at the annual meeting.
Stony Brook University to Host 2011 Sigma Xi Northeastern Research Symposium
On Saturday, April 9, 2011 the Undergraduate Student Government (USG) at Stony Brook University will host the 2011 Sigma Xi Northeastern Research Symposium at the Stony Brook University Center of Excellence for Information & Wireless Technology (CEWIT) to showcase the work of top undergraduate, graduate, and doctoral students from across the country in various fields of science.
Sponsored by the USG in collaboration with NYSTAR-designated Center for Advanced Technology (Sensor CAT), and the Office of the Vice President of Research at Stony Brook University, the Sigma Xi research symposium is regarded as one of the most prestigious student research conferences in the Northeast. Held in celebration of National Undergraduate Research Week, this year's symposium promises to be the largest and most decorated in Sigma XI history.
Among the attendees will be twenty-three of Stony Brook's own students. The students will be joined by many faculty members including three world-renowned scientists, Professor Paul Greengard of Rockefeller University, Professor Grigori Enikolopov of Cold Spring Harbor Laboratory, and Vice President for Research John H. Marburger, III of Stony Brook University, who will be speaking at this event.
"This year's conference has attracted emerging scholars from all over the country, including such elite universities as Harvard, Yale, Stanford, California Institute of Technology, Massachusetts Institute of Technology, Johns Hopkins University, University of Pennsylvania, Emory, Medical College of Wisconsin, Stony Brook University, and many others," said Yan Leyfman, Stony Brook undergraduate student and Director of this year's symposium. "This event will allow aspiring student scientists to network with each other, faculty, guests, and members of the Stony Brook community."
About the Speakers:
- Paul Greengard (Rockefeller University) was the 2000 Nobel Prize recipient in Physiology or Medicine for his work in neuronal signaling. He is currently conducting influential research on Alzheimer's disease.
- Grigori Enikolopov (Cold Spring Harbor Laboratory) is a leading authority on neural stem cells, adult neurogenesis, and the molecular basis for mood disorders. Dr. Enikolopov holds several patents, founded two biotechnology companies, and has authored over 100 publications.
- John H. Marburger, III (Stony Brook University) is a physicist, the current Vice President for Research at Stony Brook University, the third President of Stony Brook University, former Director of Brookhaven National Laboratory, President George W. Bush's Science Advisor, and former director of the federal Office of Science and Technology Policy.
For more information visit http://www.oswego.edu/~bendinsk/sigmaxiconference.html.
Institutions Represented
- Brigham and Women's Hospital
- Brookhaven National Laboratory
- Bryn Mawr College
- California Institute of Technology
- Cold Spring Harbor Laboratory
- Columbia University
- Connecticut College
- Cornell University
- CUNY Lehman College
- CUNY Queens College
- CUNY York College
- Duke University
- Emory University
- Fairfield University
- Fordham University
- Hampshire College (Amherst, MA)
- Harvard University
- Ithaca College
- Massachusetts Institute of Technology
- Medical College of Wisconsin
- Monmouth University
- National Institutes of Health
- NYU Collage of Dentistry
- Princeton University
- Rensselaer Polytechnic Institute
- Smith College
- Stanford University
- Stony Brook University
- SUNY Oswego
- SUNY Plattsburgh
- SUNY Purchase
- University of Colorado at Boulder
- University of Pennsylvania
- University of Rhode Island
- Weill Cornell Medical College
- Wells College
- Yale University
SBU Pharmacology Researchers Uncover New Role for Mitochondria
Reported in Developmental Cell, the Findings May Provide Clues to Male Infertility
Michael Frohman, M.D., Ph.D., Chair of the Department of Pharmacological Sciences at Stony Brook University School of Medicine, and colleagues, have discovered a new role for mitochondria during ribonucleic acid (RNA) processing. This latest finding, reported in Developmental Cell, may hold clues to some causes of male infertility.
Long-recognized by scientists as the powerhouse of the cell involved in the role of energy production, mitochondria help regulate numerous cell biological processes. These processes involve communication between the mitochondria and the rest of the cell via signaling pathways on the mitochondrial surface that mediate interactions with cytoplasmic proteins. Some of the pathways involve lipids.
The research team studied a specific aspect of this mitochondria activity – the machinery that generates and senses protein and lipid signals. They focused their investigation of activities that occur on and around the mitochondrial surface.
"Our experimentation uncovered a new role for mitochondria in a specialized form of RNA-processing that appears to take place at the interface between the mitochondrial surface and adjacent granules of RNA and RNA-associated proteins," says Dr. Frohman, summarizing the research results. "More specifically, we linked a signaling enzyme on the mitochondrial surface, called MitoPLD, to the production of piRNAs, which are produced from RNA copies early in spermatogenesis during meiosis."
Dr. Frohman explained that the significance of the finding is that piRNAs are known for suppressing cellular transcription (copying of RNA) and thus mobilization of genetic elements known as transposons, which make up almost half of the human genome. Many types of piRNAs also target non-transposon genes. But without piRNAs, transposons replicate, leading to widespread DNA damage and subsequent death of differentiating sperm cells.
Furthering the research, the team genetically engineered mice to lack the gene MitoPLD. They found the mice to be normal, except that the males were infertile. No effect has been seen on female fertility.
"The long-term potential significance of our laboratory findings is the possibility that some cases of male infertility may be caused by inherited mutations in MitoPLD, the signaling enzyme, especially since at least one inactivating mutation is found in the database of sequenced human DNA," says Dr. Frohman. "Conversely, pharmacological inhibitors of MitoPLD could have potential utility as male contraceptives."
In their study, titled "piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling," the authors point out that despite their findings, the piRNA generation pathway is complex and the mechanism underlying MitoPLD effects on mitochondrial morphology and fusion are unknown. However, they believe the biological significance of their work has pharmacological potential.
"Because inhibitors have been developed for other members of the same enzyme family, MitoPLD is likely a feasible target," theorizes Dr. Frohman.
Dr. Frohman's co-authors include: Huiyan Huang, Qun Gao, Xiaoxue Peng, and Krishna Sarma, of the Center for Developmental Genetics, Department of Pharmacological Sciences, Stony Brook University; Hongmei Ren and Andrew J. Morris, of the Gill Heart Institute, University of Kentucky, Lexington; and Seok-Yong Choi, of Stony Brook University and the Chonnam National University Medical School in Korea.
Stony Brook Department Declared A Landmark
Forty years ago, during his second bite into a hamburger, Paul Lauterbur experienced a "Eureka" moment: He figured out the scientific basis of what was to become the MRI.
On Friday, the American Chemical Society honored Lauterbur posthumously by designating Stony Brook University's chemistry department a historic landmark.
It's the department where he taught for more than 20 years and refined his pioneering work on magnetic resonance imaging.
Stony Brook officials and Nancy Jackson, president of the chemical society, were on hand for the presentation of a plaque marking Lauterbur's accomplishment.
He was wooed away from the school in 1985 by the University of Illinois and won the Nobel Prize for medicine in 2003 for his groundbreaking ideas that produced truly useful images. Lauterbur died four years later at the age of 78.
"He developed the mathematical theory for magnetic resonance imaging and how we can detect information from the human body," said Debiao Li, vice president of the International Society for Magnetic Resonance in Medicine.
Lauterbur's widow, Joan Dawson, an emeritus professor at the University of Illinois' Urbana-Champaign campus, said her husband's discovery came suddenly, while dining at a Long Island Big Boy restaurant with a colleague.
He jotted down his thoughts on a napkin but quickly ran out of space.
"Paul ran out to a drugstore and bought a spiral notebook, and wrote down his ideas," Dawson recalled.
In 2003, Lauterbur told Newsday on the day he won the Nobel Prize, "I knew [MRI] would be a useful tool from the very first ideas, but not how useful."
His development of MRI grew out of work involving nuclear resonance imaging.
MRI allows physicians to peer into the body without invasive surgery. It has proved useful for scanning the brain and other organs, as well as the spinal cord and joints. The images are comparable to those generated by three-dimensional CT scans but are produced without potentially harmful ionizing radiation.
MRI uses powerful magnets and radio waves to take pictures of the body. Dawson said she's touched that Lauterbur is still remembered at Stony Brook.
"My husband has been awarded many honors over the years," she said. "But this would be very special to him. And he would be proud to know this department still remembers him."


text:
JFK Website (0)
Digital Archives (2)
Common Search Term: Mac
Textual folder(1)
Papers of John F. Kennedy. Presidential Papers. President's Office Files.(1)
John F. Kennedy Personal Papers(1)
MacRae, Walter S. (Walter Stanislaus), 1903-(1)
Walter S. MacRae at a ranch in northern Arizona. MacRae is standing in front of a barn leaning against a fence. To his right are two cats perched on the fence. MacRae, who wrote frequently to President John F. Kennedy, sent the photograph with a letter dated March 4, 1963. The postscript for the letter is typewritten on the verso of the photograph ...
This folder contains a letter to John F. Kennedy from a man identified only as "Mac" concerning a mutual friend.
Search powered by Oracle Endeca ®.
JOHN F. KENNEDY PRESIDENTIAL LIBRARY AND MUSEUMColumbia Point, Boston MA 02125 (617) 514-1600


text:
Definitions for paderewskiˌpæd əˈrɛf ski, -ˈrɛv-
This page provides all possible meanings and translations of the word paderewski
Random House Webster's College Dictionary
Pa•de•rew•skiˌpæd əˈrɛf ski, -ˈrɛv-(n.)
Ignacy Jan, 1860–1941, Polish pianist, composer, and statesman.
Category: Biography
Princeton's WordNet
Paderewski, Ignace Paderewski, Ignace Jan Paderewski(noun)
Polish pianist who in 1919 served as the first Prime Minister of independent Poland (1860-1941)
Find a translation for the paderewski definition in other languages:
Select another language:
Discuss these paderewski definitions with the community:
Use the citation below to add this definition to your bibliography:
"paderewski." Definitions.net. STANDS4 LLC, 2014. Web. 22 Dec. 2014. <http://www.definitions.net/definition/paderewski>.