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Marlin And Manitowoc Launch New Financing Program
MOUNT LAUREL, N.J., Aug. 16, 2012 (GLOBE NEWSWIRE) -- Marlin Business Services Corp. (Nasdaq:MRLN) and Manitowoc Foodservice, division of The Manitowoc Company, Inc. (NYSE:MTW), have formed a strategic alliance to provide financing solutions for Manitowoc's channel partners and equipment purchasers nationwide.
Marlin has supported the foodservice industry since its inception in 1997. The strategic alliance will enable Manitowoc customers to quickly and cost-effectively acquire the equipment and technology needed to expand and grow, while helping Manitowoc's channel partners improve transaction efficiency. The alliance with Manitowoc, a world-class manufacturer of foodservice equipment and a leader in the market, will enable Marlin to further grow its presence in the growing foodservice industry.
"We are proud to offer flexible financing plans with competitive terms to Manitowoc customers under this new program," said Dan Dyer, Marlin's CEO. "With our origination and underwriting capabilities and expertise in the foodservice industry, Manitowoc channel partners and customers can expect best-in-class service.""We look forward to a thriving relationship with Marlin Business Services Corp.," said Dean Landeche, Manitowoc's SVP of Marketing. "For foodservice operators of all types, being able to purchase our products with more ease and with the backing of a strong and reliable organization like Marlin is an exceptional benefit. For our channel partners, Marlin's support will mean improving the speed of business by eliminating long approval waiting periods, giving Manitowoc channel partners another smart competitive advantage." About Marlin Business Services Corp. Marlin Business Services Corp. is a nationwide provider of innovative equipment financing solutions for small and mid-size businesses. Since its inception in 1997, Marlin has financed a wide array of commercial equipment and software for a quarter of a million business customers. Marlin's mission is to offer convenient and cost-effective financing products while providing the highest level of customer service. Marlin is publicly traded (Nasdaq:MRLN) and owns and operates a federally regulated commercial bank, Marlin Business Bank. For more information, visit www.marlincorp.com or call toll free at (888) 479-9111. The Marlin Business Services Corp. logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=4087
CONTACT: Marlin Business Services Corp. Media Relations firstname.lastname@example.com
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A red swimmer
Colette M. Metcalf 12/7/2012 2:47:59 AMCool image!! #1502265
Jeff W. Robinson 12/7/2012 2:54:37 AMVery cool Jüri! #10454255
Jyri Vissak 12/7/2012 5:05:33 AMThanks a lot. #10454445
I made tis photo last summer in Paris.
Exif: F Number: 5.6, Exposure Bias Value: 0.00, ExposureTime: 1/80 seconds, Flash: did not fire, compulsory flash mode, ISO: 100, White balance: Auto white balance, FocalLength: 21.00 mm, Model: Canon EOS 7D
Uploaded on 12/7/2012 2:22:52 AM
Camera: Canon EOS 7D Digital SLR Camera
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TN Car Buying Paperwork - Bill of Sale, Title Transfers, Duplicate Titles and RegistrationBe prepared with the appropriate paperwork and applications when you buy a car in Tennessee - bill of sale, title transfers, duplicate titles, license plates..
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Ladders damage cars on Interstate 89April 28,2013Vehicles damaged
by ladders on I-89
SHARON — Extension ladders that somehow ended up in the middle of the Interstate 89 northbound lane Friday afternoon damaged two vehicles but caused no injuries, according to Vermont State Police.
Police were called to a section of the divided highway near mile marker 15 just before 5:30 p.m. after two vehicles struck the ladders.
Police didn't say how the items came to be in the roadway, but indicated it may have been unintentional.
While the damage to the two cars was minimal, police said reminded motorists that failing to properly secure items while driving on public highways could result in a ticket and fine of up to $1,191.MORE IN This Just InPolice are seeking information about a pair of robberies in Rutland and Wallingford Wednesday night. Full StoryBy now we are in full- blown holiday mode, but despite our busy schedules, there is always time... Full Story
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Created: 07/16/2014 8:20 PM
By: Kristen Garcia, KOB.com
One family continues to look for their dog after he went missing on July 5th.
The beagle, named Snoopy, went missing from his home near Troxel Ln. and Hallet Ranch Ct. This area is north of I-40 and west of Mountain Valley Rd. in Tijeras NM.
Snoopy, has always been a real home-body,content to stay at home with his family and never went beyond the driveway.
The family believes that 'Snoopy' is desperately trying to find his owner, Russ, who has been hospitalized since June 20. Before he went missing, he had tried to jump into the car of Russ' wife, Renee, and had to be taken out.They believe he could've followed the smells of Renee's car until it put him on the freeway.
Snoopy is tri-colored with white, orange, and black and was last seen wearing a red collar with tags.
There are reports that he may have been spotted in the Edgewood area on Monday.
There is a reward for his return. If found please call (505) 615-6444 or (505) 286-8966. For more information visit East Mountain Pet Alert's Facebook page.
KOB welcomes a lively and courteous discussion as long as you follow the rules of conduct set forth in our Terms of Use. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Use.
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John C. Reilly the Academy Award-nominated actor, musician and one-time on-screen step brother of Will Ferrell surely knows something about video games. He provides the voice of the main character in Disneys Wreck-It Ralph, a movie steeped heavily in arcade culture.
He was a teenager during the Atari era and seems like the kind of guy who would do well on a trivia quiz, which is why we attempted to give him one until he heard some of the questions.
Lets skip the quiz, Reilly, 47, suggested after we got to question No. 3. (Which journalist endorsed the home video game console Intellivision? Answer: George Plimpton.
Yes, the questions might have been a little obscure.) All the gamers will be mad at me for not knowing the answers.
Its hard to be angry with Reilly, especially when he confesses that he once was obsessed with Space Invaders and enjoys a quality round of Touch Tanks on his iPad.
Q: Were you ever really into video games?
I was of the first generation of people that had video games come into their lives. I remember when Space Invaders arrived in the bowling alley where I used to hang out. Going from pinball machines to Space Invaders was such a quantum leap. It was super-exciting. So needless to say, I spent a lot of money and time . . .
Q: At the bowling alley.
At the bowling alley, and then at the convenience store on the corner. Wherever. Those games used to be everywhere. You could go into any kind of hot dog place and there would be a couple of machines in there.
Q: Do you play video games now?
Every once in a while, if I have a cold or something and Im laid up in bed. I ended up playing Touch Tanks, which is basically just moving a tank around a board and blowing up other tanks. It doesnt get any more complicated than that.
In general, those are the sorts of things that Im drawn to, as opposed to things where you need to memorize the technical aspects of different weapons systems.
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Wee-Wee Pads Protect Your Floors From WeeThe super absorbent Wee-Wee Pad is scientifically treated to attract puppies when nature calls. Plastic lining prevents damage to floors and carpets. Four Paws Wee-Wee Pads are versatile in that they can be used for puppy pad training or as an everyday alternative to the outdoors when pets are housebound.
50 Pack. The original Wee Wee pads measure 22 in x 23 in.
Pet Supplies we provide similar to Four Paws Wee-Wee Pads: reusable puppy pads & ValuePad dog training pads
6 Review(s)
- Wee Wee Pads are good! Review by Linda N.
Your Rating
For a smaller pad, my Morkie definitely uses them occasionally--wish they were a bit thicker, however. Other than that, a well-made product. (Posted on 7/9/14)
- best pads that i have found Review by jo
Your Rating
hope that you continue to carry this product (Posted on 2/26/14)
- Great Review by Beckster
Your Rating
Have used these pads before and have liked them a lot.The price was the great +. (Posted on 1/10/14)
- Excellent product Review by Armando
Your Rating
These are the best training pads. (Posted on 10/18/13)
- Four Paws Puppy Pads Review by SAM
Your Rating
I've tried numerous training pads for my 3 small house dogs. I can honestly say these are the best on the market. The 22"x23" size is larger than most pads and the quilting/liner is absorbent. No need to double layer the pads to prevent leaking thru the pad. (Posted on 8/21/13)
- Puppy pads Review by Anna
Your Rating
Just got a new puppy. Pads are a great size to prevent accidents. (Posted on 3/10/11)
6 Review(s)


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While on my adults only trip last month I found myself frequently hopping up on a chair at The Drop Off Pool Bar to soak up the tropical atmosphere and quench my thirst.Details »
pool bar
Art of Animation's Drop Off Pool Bar
Category: Disney World Tags:
Siestas Poolside Bar at the Coronado Springs Resort Dig Site
Continuing our Friday bar hop, we've covered the super chic Rix Lounge and the charming lakeside retreat that is the Laguna Bar, but have you been over to Siesta's Pool Bar and Grill at the Coronado Springs Resort?Details »
Category: Disney World Tags:
Disney Wilderness Lodge: Trout Pass Pool Bar
Down by the water at Disney's Wilderness Lodge you'll find a little cabin nestled on the shores of a splendid lake. There you can meet some great folks serving up fun in the Florida sun at the Trout Pass Pool Bar.Details »
Category: Disney World Tags:
Lunch at Samawati Springs Maji Pool Bar
When spending a day by the Uzima Springs easy to grab a quick bit to eat at Animal Kingdom Lodge's Counter Service eatery, Mara and take it back to a poolside table. However what if you're spending lunchtime at Kidani Village's Pool & Water Playground Samawati Springs?Details »
Category: Disney World Tags:
Uzima Springs Pool Bar: Caribbean Limeade | Eating WDW
A beautiful day seemingly requires relaxing next to a pool with a mixed drink in hand. At Animal Kingdom Lodge, my choice place is at Uzima Springs Pool Bar.Details »
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Guest Review: Meadow Snack Bar at Fort Wilderness Resort | the disney food blog
Review of the Meadow Recreation Area near the center of Fort Wilderness Resort and Campground.Details »
Category: Disney World Tags:
Banana Cabana Pool Bar at Disney's Caribbean Beach Resort
Amongst Walt Disney World pool bars, this one may very well have the most cult-like following of all. Guests and fans of Disney's Caribbean Beach Resort will happily sing the praises of the Banana Cabana Poolside Bar at Old Port Royale.Details »
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Disney's Port Orleans Mardi Grogs Pool Bar
Sitting back a bit from the hustle and bustle of "Doubloon Lagoon" you can find Mardi Grogs in the lively and fun swimming area of Port Orleans French Quarter that has the celebratory feel of all that is Mardi Gras.Details »
Category: Disney World Tags:
Must Do Milkshake: Frozen Hot Chocolate at Hilton Bonnet Creek Resort
Served at Beech at the Hilton Bonnet Creek Resort, the Frozen Hot Chocolate Milkshake is a tasty concoction to enjoy at this pool bar overlooking the resort's lazy river. Feel the chill!Details »
Category: Disney World Tags:
Banana Cabana pool bar - a fan favorite!
The Banana Cabana pool bar is truly a Caribbean Beach Resort fan favorite. It's a great place to relax and let the tension melt away. It's also "stocked" with some of the nicest and chattiest bartenders around!Details »
Category: Disney World Tags:
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Friday, October 18, 2013 - 3:32pm
Fort Worth — For those who were convinced Johnny Manziel's high profile partying, court side seats, alleged autograph shows, online classes and late night talk show appearances were going to derail his sophomore season - congratulations. You bought stupid, too.
For more go to the Fort Worth Star-Telegram. [1]
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(based on
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of respondents would recommend this to a friend.
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Bottom Line
Yes, I would recommend this to a friend
I love my car. I traded in a 2007 Dodge Caliber for the Charger. the charger has always been my dream car. The only thing I would change is to give it front wheel drive like the caliber. It is not a good car for the snow, but the weight seems to help. Other than that, I love it. Looking to trade in for a 2014. I don't like the front of the 2015. Took the muscle away.
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I have been looking at the Charger since the 7th gen redesign in 2011, but never had a big enough reason to pull the trigger. Well, I waited until the 8th gen redesign facts started to flow, and knew that it was now or never (or at least, not for the foreseeable future). First and foremost, I wanted a Hemi V8, and having lived in colder climates for the last two decades, I wanted a Hemi V8 with AWD. Starting in 2015, this combination is no longer an option. That's right, Chrysler/Dodge killed the "unpopular" combination of big power and enhanced handling (more on that later). Second, the 2015 redesign takes the beloved aggressive Charger and makes it look more like it's little sibling, the Dart. Usually, car makers are trying to make their entry-level offerings look more like their big-league brothers, not the other way around. Those two bits of news sent me on a scramble to find a 2014 Hemi V8/AWD Charger, and I found one in a beautiful granite crystal metallic, and it's now about to hit the 1000 mile mark. Not a hiccup, great treatment and service from the dealer, and drives better than expected. The interior is leaps and bounds above most other vehicles in this segment, and it's quiet - even when putting the pedal down. I'm glad I pulled the trigger, and I think anyone else who has hesitations about doing it now, especially if you want power and control, should seriously try and find one before it's too late.
As for the "unpopular" Hemi/AWD combination, my belief is that many people were holding off on buying one (hence, unpopular) because the 7th gen didn't offer the newer 8-speed auto transmission with the Hemi V8. Already taking a hit in MPG due to AWD, people wanted to wait for the trifecta offering of the Hemi/AWD/8-speed AT. No dice on that one... the 2015 will indeed offer the Hemi V8 with the new AT, but not with AWD. As for the MPG, it's a front disconnect AWD system that only engages when needed, so you're RWD for most everyday driving, and I can tell you that the MPG are much better than the 15/23 (AWD) numbers. I routinely will get upwards of 28-29 on the highway and 18-19 in the city. YMMV.
Not that this is anything more than heresay, but a buddy of mine who's works for Chrysler/Dodge in another part of the country told me that people started calling in asking to locate and purchase Hemi/AWD models as soon as the 2015 news started to hit.
Bought this 2014 Dodge Charger about 10 days ago. I'm getting about 33mpg's and absolutely love driving this car. I stepped up from a ford focus. I love how this car rides, performs and sounds. I'm a married man with 5 kids and I think this is a great "I'm married, but still dig cars" look and style. Great job Dodge! I hope this car lasts me 100,000+ miles
Bottom Line
No, I would not recommend this
2014 Charger SXT, AWD with 8 speed transmission. When coming to a stop, the transmission has a very harsh downshift. The downshift is so abrupt, tires will slide on wet payment. As of May 2014 the transmission was reprogrammed (problem still existed). Then the valve body was replaced, downshifts still unacceptable.
I traded my Mits 2006 GT Special Edition Eclipse for this 5.7 Hemi, I have owned many Camaro Z28 in my time with 305 and 350 LT1 Engines. This Dodge Hands down has better off line acceleration and top speed to include quarter mile times. Muscle Car is what this is. Love the Beats Audio System with 552 Amps. I have never owned a dodge before, but very happy with this purchase. Dealer and rebates were great. Glad we bought it 1/12/2014
I would have prefered a Challenger but my wife wanted a 4-door. Good looks, Great power, smooth ride, we are getting over 29 MPG and the engine has 800 miles on it. Cannot wait to see how it does after breaking in.
My wife and I just purchased this car a couple of weeks ago. This is a very smooth, quiet car with ample power (V6, 8-speed trans combo). The transmission seems to always be in the right gear without losing power, it has a continous flow of power. We currently get 28mpg city/highway. I have never purchased a Dodge product but I'm happy that I did, very pleased. This is one of the best cars I've bought. We test drove other cars like the Toyota Venza and Toyota Avalon and preferred the Charger (we traded in our 2005 Toyota Avalon). My only complaint is the lack of the sliding arm rest.


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Hi Folks,
Just about to create user accounts for september new intake and wondered if anyone could point me in the direction of software/tool to make this task easier. I used account management spreadsheet from wisesoft last year but wondered if there was any better alternatives.
P.S. I probably being slow but has the dowloads section been removed? been a while since last login.


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Are you Zsolt Juranyi?Claim your profile
Publications (21)50.67 Total impact
Article: Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone.[Show abstract] [Hide abstract]
ABSTRACT: The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon hyperfunctional dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system. The therapeutic efficacy of all atypical antipsychotics is explained in part by antagonism of the dopaminergic neurotransmission, mainly by blockade of D(2) dopamine receptors. N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia can be reversed by glycine transporter type-1 (GlyT-1) inhibitors, which regulate glycine concentrations at the vicinity of NMDA receptors. Combined drug administration with D(2) dopamine receptor blockade and activation of hypofunctional NMDA receptors may be needed for a more effective treatment of positive and negative symptoms and the accompanied cognitive deficit in schizophrenia. To investigate this type of combined drug administration, rats were treated with the atypical antipsychotic risperidone together with the GlyT-1 inhibitor Org-24461. Brain microdialysis was applied in the striatum of conscious rats and determinations of extracellular dopamine, DOPAC, HVA, glycine, glutamate, and serine concentrations were carried out using HPLC/electrochemistry. Risperidone increased extracellular concentrations of dopamine but failed to influence those of glycine or glutamate measured in microdialysis samples. Org-24461 injection reduced extracellular dopamine concentrations and elevated extracellular glycine levels but the concentrations of serine and glutamate were not changed. When risperidone and Org-24461 were added in combination, a decrease in extracellular dopamine concentrations was accompanied with sustained elevation of extracellular glycine levels. Interestingly, the extracellular concentrations of glutamate were also enhanced. Our data indicate that coadministration of an antipsychotic with a GlyT-1 inhibitor may normalize hypofunctional NMDA receptor-mediated glutamatergic neurotransmission with reduced dopaminergic side effects characteristic for antipsychotic medication.Neurochemical Research 12/2010; 35(12):2096-106. · 2.13 Impact Factor
Article: The synaptic and nonsynaptic glycine transporter type-1 inhibitors Org-24461 and NFPS alter single neuron firing rate in the rat dorsal raphe nucleus. Further evidence for a glutamatergic-serotonergic interaction and its role in antipsychotic action.[Show abstract] [Hide abstract]
ABSTRACT: Single neuron firing rate was recorded from dorsal raphe nucleus of anesthetized rats. The firing rate of raphe neurons varied from 4 to 8 discharge per second before drug administration and this neuronal activity was decreased by L-701,324 (2 mg/kg i.v. injection), a competitive antagonist of glycineB binding site of N-methyl-D-aspartate (NMDA) receptors. The glycine transporter type-1 (GlyT1) antagonists Org-24461 (10 mg/kg i.v.) and NFPS (3 mg/kg i.v.) reversed the inhibitory effect of L-701,324 on single neuron activity recorded from dorsal raphe nucleus of the rat. Org-24461 and NFPS both tended to increase the raphe neuronal firing rate also when given alone but their effect was not significant. This finding serves further evidence that glutamate released from axon terminals of the cortico-striatal projection neurons stimulates serotonergic neurons in the raphe nuclei and this effect is mediated at least in part by postsynaptic NMDA receptors. Thus, GlyT1 inhibitors are able to reverse the hypofunctional state of NMDA receptors, suggesting that these drugs may have beneficial therapeutic effects in neurological and psychiatric disorders characterized with impaired NMDA receptor-mediated transmission.Neurochemistry International 02/2008; 52(1-2):130-4. · 2.66 Impact Factor
Article: Immunohistochemical and in situ hybridization studies on glycine transporter 1 after transient ischemia in the rat forebrain.[Show abstract] [Hide abstract]
ABSTRACT: Glycine is a critical factor in ischemia as reduced astrocytic and increased extracellular glycine levels aggravate the neurotoxic effect of glutamate and consequently, increase the extent of brain damage. Extracellular levels of glycine are primarily regulated by the plasma membrane glycine transporter 1. In the present study, we examined the effects of transient ischemia (1 h occlusion of the middle cerebral artery; followed by 0 h, 0.5 h, 1 h, 2 h, 4 h, 24 h or 48 h reperfusion) on immunoreactivity and mRNA expression of glycine transporter 1 in the rat forebrain. In control animals, glycine transporter 1-immunoreactivity was strong in diencephalic and certain telencephalic structures, moderate in the globus pallidus, and rather low in the cortex and striatum. In situ hybridization studies revealed a similar distribution pattern of glycine transporter 1 mRNA expression. One hour occlusion of the middle cerebral artery resulted in a significant decrease in ipsilateral glycine transporter 1-immunoreactivity and mRNA expression in a circumscribed region of the preoptic/hypothalamic area; both the immunoreactivity and mRNA exhibited further reductions with increasing reperfusion time. In contrast, the cerebral cortex and the globus pallidus showed an increase of glycine transporter 1-immunoreactivity after 0.5 h reperfusion; the elevation proved to be transient in the somatosensory cortex and remained sustained in the globus pallidus after longer reperfusion times. Western blot analysis of globus pallidus samples from the ipsilateral side confirmed higher glycine transporter 1 protein levels. These results suggest an elevated expression of the transporter protein facilitating the glial uptake of glycine from the extracellular space. However, glycine transporter 1 mRNA expression was not significantly different in the penumbra regions from the corresponding contralateral sites of the injury. Together, these findings indicate that post-translational mechanisms are of primary importance in elevating glycine transporter 1 protein levels following transient ischemia.Neurochemistry International 01/2008; 52(4-5):799-808. · 2.66 Impact Factor
Article: Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism.[Show abstract] [Hide abstract]
ABSTRACT: Although levodopa is the current "gold standard" for treatment of Parkinson's disease, there has been disputation on whether AMPA receptor antagonists can be used as adjuvant therapy to improve the effects of levodopa. Systemic administration of levodopa, the precursor of dopamine, increases brain dopamine turnover rate and this elevated turnover is believed to be essential for successful treatment of Parkinson's disease. However, long-term treatment of patients with levodopa often leads to development of dyskinesia. Therefore, drugs that feature potentiation of dopamine turnover rate and are able to reduce daily levodopa dosages might be used as adjuvant in the treatment of patients suffering from Parkinson's disease. To investigate such combined treatment, we have examined the effects of two non-competitive AMPA receptor antagonists, GYKI-52466 and GYKI-53405, alone or in combination with levodopa on dopamine turnover rate in 6-hydroxydopamine-lesioned striatum of the rat. We found here that repeated administration of levodopa, added with the peripheral DOPA decarboxylase inhibitor carbidopa, increased dopamine turnover rate after lesioning the striatum with 6-hydroxydopamine. Moreover, combination of levodopa with GYKI-52466 or GYKI-53405 further increased dopamine turnover enhanced by levodopa administration while the AMPA receptor antagonists by themselves failed to influence striatal dopamine turnover. We concluded from the present data that potentiation observed between levodopa and AMPA receptor antagonists may reflect levodopa-sparing effects in clinical treatment indicating the therapeutic potential of such combination in the management of Parkinson's disease.Brain Research Bulletin 04/2007; 71(5):501-7. · 2.94 Impact Factor
Article: Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats.[Show abstract] [Hide abstract]
ABSTRACT: 2,3,5-Triphenyltetrazolium chloride (TTC) staining measures tissue viability used to evaluate infarct size. The goal of this study was to compare viability of neuronal tissue during the early phases of ischemia-reperfusion assessed either by perfusion of the brain with TTC solution transcardially, in vivo, or by staining brain slices, in vitro. The middle cerebral artery was occluded for 1 h in male SPRD rats and then reperfused for 0, 1, 4, 8, 16 and 24 h. Ischemic damage was evaluated by TTC staining, in vivo and in vitro, and by histology (Luxol Fast Blue and Fluoro-Jade staining, electron microscopy). Core volume of tissue injury measured in vivo was large at 0 h and steadily decreased by 50% (p<0.001) up to 16 h, but substantially increased from 16 to 24 h of reperfusion. In contrast, a significant core volume appeared at 4 h only, in vitro, and gradually increased up to 24 h. Core volume was larger in vivo than in vitro at all times except at 16 h when the opposite was observed. Evans blue administered intracardially stained TTC-negative areas at 1 and 24 h. Histology covered the evolution of serious tissue injury but also demonstrated some morphologically preserved neurons in the infracted area at 24 h. Formation of formazan from TTC can depend on both the staining method and the metabolic burden of the brain tissue causing uncertainties in the volume of ischemia-induced brain injury measured by TTC staining.Brain Research 10/2006; 1116(1):159-65. · 2.88 Impact Factor
Article: Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study.[Show abstract] [Hide abstract]
ABSTRACT: Cholinesterase inhibitors including donepezil, rivastigmine, and galantamine and the N-methyl-D-aspartate (NMDA) antagonist, memantine are the medications currently approved for the treatment of Alzheimer's disease (AD). In addition to their beneficial effects on cognitive and functional domains typically disrupted in AD, these agents have also been shown to slow down the emergence of behavioral and psychotic symptoms associated with this disease. However, the underlying mechanisms for these therapeutic effects remain poorly understood and could involve effects of these medications on non-cholinergic or non-glutamatergic neurotransmitter systems respectively. These considerations prompted us to initiate a series of investigations to examine the acute and chronic effects of donepezil (Aricept (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-1 hydrochloride and memantine (1-amino-3,5-dimethyladamantane hydrochloride C12H21N.HCl)). The present study focuses on the acute effects of donepezil and memantine on brain extracellular levels of acetylcholine, dopamine, serotonin, norepinephrine and their metabolites. We assayed changes in the ventral and dorsal hippocampus and the prefrontal and medial temporal cortex by microdialysis. Memantine resulted in significant increases in extracellular dopamine (DA), norepinephrine (NE), and their metabolites, in the cortical regions, and in a reduction of DA in the hippocampus. Donepezil produced an increase in extracellular DA in the cortex and in the dorsal hippocampus. Norepinephrine increased in the cortex; with donepezil it increased in the dorsal hippocampus and the medial temporal cortex, and decreased in the ventral hippocampus. Interestingly both compounds decreased extracellular serotonin (5HT) levels. The metabolites of the neurotransmitters were increased in most areas. We also found an increase in extracellular acetylcholine (ACh) by memantine in the nucleus accumbens and the ventral tegmental area. Our results suggest both region and drug specific neurotransmitter effects of these agents as well as some similarities. We conclude that drugs influencing cognitive mechanisms induce changes in a number of neurotransmitters with the changes being both region and drug specific. Release and metabolism are altered and extracellular neurotransmitter levels can be increased or decreased by the drugs. Other studies are in progress to determine the pharmacological effects associated with chronic treatment with these compounds, which may be more pertinent to the clinical situation in which patients take these medications for months or years.Brain Research Bulletin 04/2006; 69(2):204-13. · 2.94 Impact Factor
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ABSTRACT: The ionotropic glutamate receptor NMDA is allosterically modulated by glycine, a coagonist, its presence is an absolute requirement for receptor activation. The transport of glycine in glutamatergic synapse is carried out by glycine transporter-1 (GlyT1), a Na+/Cl(-)-dependent carrier molecule. The primary role of GlyT1 is to maintain glycine concentrations below saturation level at postsynaptic NMDA receptors. Several isoforms of GlyT1 (a-e) have been identified, which are expressed both in glial and neuronal cell membranes. GlyT1 operates bidirectionally: it decreases synaptic glycine concentration when operates in normal mode and releases glycine from glial cells as operates in a reverse mode. It is expected that non-transportable, non-competitive inhibitors of GlyT1 may have therapeutic value in CNS disorders characterized by hypofunctional NMDA receptor-mediated glutamatergic neurotransmission. Accordingly, GlyT1 inhibitors exhibited antipsychotic profile in a number of animal tests. The first promising in vitro and in vivo experiments with glycine itself, and its N-methyl analogue, sarcosine, had initiated the syntheses of potential GlyT1 inhibitors with more complex structures, in which, however, the glycine or sarcosine moiety had always been incorporated. Those attempts led to the development of two compounds, ALX-5407 and Org-24461 with high inhibitory potency; however, none of which is now considered as a drug candidate due, most probably, to safety and/or pharmacokinetic issues. More recently, several structurally new series of highly potent inhibitors with no aminomethylcarboxy group have also been discovered. Some of them might be expected to fulfill all requirements for clinical development. The new generation of GlyT1 inhibitors may represent a novel treatment of patients suffering from schizophrenia and/or other neuropathological conditions.Current Medicinal Chemistry 02/2006; 13(9):1017-44. · 3.72 Impact Factor
- Current Medicinal Chemistry - CURR MEDICINAL CHEM. 01/2006; 13(9):1017-1044.
Article: P.3.d.011 In vitro and in vivo characterization of glycine transporter type-1 by two inhibitors, Org24461 and NFPSEuropean Neuropsychopharmacology - EUR NEUROPSYCHOPHARMACOL. 01/2006; 16.
Article: A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction.[Show abstract] [Hide abstract]
ABSTRACT: Midbrain slices containing the dorsal and medial raphe nuclei were prepared from rat brain, loaded with [3H]serotonin ([3H]5-HT), superfused, and the electrically induced efflux of radioactivity was determined. The nonselective 5-HT receptor agonist 5-carboxamido-tryptamine (5-CT; 0.001 to 1 microM) inhibited the electrically stimulated [3H]5-HT overflow from raphe nuclei slices (IC50 of 3.34 +/- 0.37 nM). This effect of 5-CT on [3H]5-HT overflow was antagonized by the 5-HT7 receptor antagonist SB-258719 (10 microM) and the 5-HT(1B/1D) antagonist SB-216641 (1 microM), the IC50 values for 5-CT in the presence of SB-258719 and SB-216641 were 94.23 +/- 4.84 and 47.81 +/- 4.66 nM. The apparent pA2 values for SB-258719 and SB-216641 against 5-CT were 6.43 and 7.12, respectively. The inhibitory effect of 5-CT on [3H]5-HT overflow was weakly antagonized by 10 microM of WAY-100635, a 5-HT1A receptor antagonist (IC50 6.65 +/- 0.56 nM, apparent pA2 4.99). The antagonist effect of SB-258719 (10 microM) on 5-CT-evoked [3H]5-HT overflow inhibition was also determined in the presence of 1 microM SB-216641 or 1 microM SB-216641 and 10 microM WAY-100635, and additive interactions were found between the antagonists of 5-HT7 and 5-HT1 receptor subtypes. Addition of the Na+ channel blocker tetrodotoxin (1 microM) in the presence of SB-216641 (1 microM) and WAY-100635 (10 microM) attenuated the inhibitory effect of 5-CT on KCl-induced [3H]5-HT overflow. These findings indicate that 5-CT inhibits [3H]5-HT overflow from raphe nuclei slices of the rat by stimulation of 5-HT7 and 5-HT(1B/1D receptors, whereas the role of 5-HT1A receptors in this inhibition is less pronounced. They also suggest that 5-HT7 receptors are probably not located on serotonergic neurons and thus may serve as heteroreceptors in regulation of 5-HT release in the raphe nuclei. 5-CT (0.1 microM) also inhibited [3H]glutamate release, and SB-258719 (10 microLM) suspended this effect. We therefore speculated that the axon terminals of the glutamatergic cortico-raphe neurons may possess 5-HT7 receptors that inhibit glutamate release, which consequently leads to decreased activity of serotonergic neurons. The postulated glutamatergic-serotonergic interaction in the raphe nuclei was further evidenced by the finding that N-methyl-D-aspartate and AMPA enhanced [3H]5-HT release.Neurochemical Research 09/2004; 29(8):1487-97. · 2.13 Impact Factor
Article: Neurotransmitter release in experimental stroke models: the role of glutamate-GABA interaction.[Show abstract] [Hide abstract]
ABSTRACT: Stroke or cerebrovascular accident reduces blood flow and decreases oxygen supply (ischemia) in brain tissue. This may be resulted from vascular obstruction when a blood vessel is blocked or by hemorrhage when bleeding occurs into the brain tissue. Decrease in oxygen supply shifts pH to acidosis and increases extracellular K+ concentration, which depolarizes neural cell membrane. Anoxic depolarization leads to excessive release of glutamate, which then activates various glutamate receptors in the synapse or the extrasynaptic space. Opening of ionotropic glutamate receptors (NMDA, AMPA and kainate receptors) causes influx of Na+ through the activated glutamate-gated ion channels. In response to anoxia, Ca2+ also enters the cells in excessive amounts via activated NMDA receptors and Ca2+-permeable AMPA receptors. This will lead to activation of several Ca2+-dependent intracellular signal transduction pathways (proteases, kinases, endonucleases, lipoxygeneses and nitric oxide synthase), which ultimately leads to neural death (Vizi et al., 1996; Parsons et al., 1998).Advances in experimental medicine and biology 02/2004; 541:21-37. · 1.83 Impact Factor
Article: AMPA receptor blockade potentiates the stimulatory effect of L-DOPA on dopamine release in dopamine-deficient corticostriatal slice preparation.[Show abstract] [Hide abstract]
ABSTRACT: The release of [3H]dopamine was measured in rat corticostriatal slice preparations that contained the striatum and the adjacent prefrontal cortex to maintained glutamatergic corticostriatal afferentation. These slices were prepared from either nontreated or 6-hydroxydopamine-pretreated rats. The slices were loaded with [3H]dopamine, submerged in a two-compartment bath so that the cortical region was contained in one compartment, the corpus callosum was passed through a silicone greased slot, and the striatal region was contained in the other compartment. The cortical and the striatal parts were superfused with Krebs-bicarbonate buffer independently. The release of [3H]dopamine was determined from the striatal part at rest and in response to electrical stimulation of the cortical area. Electrical stimulation of the cortical part increased the release of [3H]dopamine from the striatal part of the slices, and this release was found to be higher after lesion of the nigrostriatal dopaminergic pathway with 6-hydroxydopamine. Cortically evoked [3H]dopamine release was even higher in the presence of the dopamine precursor L-DOPA after 6-hydroxdopamine lesion. Perfusion of GYKI-53405, a noncompetitive AMPA receptor antagonist, in combination with L-DOPA further increased both basal and stimulation-evoked [3H]dopamine release, whereas GYKI-53405 by itself did not influence basal [3H]dopamine outflow from striatum. These findings indicate that, in parkinsonian striatum, the stimulatory effect of L-DOPA on dopamine release is potentiated by AMPA receptor blockade, and the antiparkinsonian effect of GYKI-53405 may be due to its L-DOPA sparing effect.Critical Reviews in Neurobiology 02/2004; 16(1-2):129-39.
Article: [3H]Dopamine release in striatum in response to cortical stimulation in a corticostriatal slice preparation.[Show abstract] [Hide abstract]
ABSTRACT: A new method has been developed to investigate corticostriatal glutamatergic influence on [3H]dopamine release in striatum in complex corticostriatal slice preparation in vitro. Horizontal slices containing the striatum and the adjacent prefrontal cortex of rat brain were cut in a plane that maintains corticostriatal connections. After incubation with [3H]dopamine, slices were submerged in a two-compartment bath so that the cortical region was contained entirely in one compartment, corpus callosum passed through a silicone greased slot, and the striatal region was contained in the other compartment. A cannula was placed just above the striatal part of the slice and effluent was collected with a peristaltic pump, released tritiated materials were counted with a liquid scintillation counter. Electric field stimulation of cortex increased the release of [3H]dopamine in the striatum. Bicuculline (1 mM) increased the basal and stimulated release of [3H]dopamine in the striatum in response to cortical stimulation of cortex indicating the GABAergic control on dopamine release. This method allows investigation of the effect of cortical stimulation on glutamate-dopamine-GABA interactions in the striatum in vitro that might help to understand better the neurochemical background of schizophrenia or Parkinson's disease.Journal of Neuroscience Methods 07/2003; 126(1):57-67. · 2.11 Impact Factor
Article: Involvement of P2 purinoceptors and the nitric oxide pathway in [3H]purine outflow evoked by short-term hypoxia and hypoglycemia in rat hippocampal slices[Show abstract] [Hide abstract]
ABSTRACT: The objective of this study was to study how the outflow of []purines is altered during a brief period of ischemic-like conditions in superfused hippocampal slices and to show whether it is regulated by P2 purinoceptors and the nitric oxide (NO) pathway. The outflow of []purines increased in response to 5 min of combined hypoxia/hypoglycemia. High performance liquid chromatography analysis verified the efflux of []adenosine-triphosphate, []adenosine-diphosphate, []adenosine-monophosphate, []adenosine, []inosine, and []hypoxanthine in response to ischemic-like conditions. The P2 receptor antagonists suramin and pyridoxal-phosphate-6-azophenyl-2′-4′-disulphonic-acid-tetrasodium (PPADS) reduced significantly the []purine efflux evoked by ischemic-like conditions, showing that P2 purinoceptors are involved in the initiation of purine outflow. The NO synthase inhibitor N-nitro-l-arginine-methyl-ester (l-NAME) attenuated significantly the []purine outflow, evoked by ischemic-like conditions, while 7-nitroindazole (7-NI) caused only a mild decrease in the outflow. The NO donor sodium nitroprusside increased significantly the basal efflux of []purines. In summary, a brief period of combined hypoxia/hypoglycemia induced the efflux of ATP in addition to the outflow of other purines. Since P2 receptor antagonists decreased the []purine outflow evoked by ischemic-like conditions we propose that ATP, acting on P2 purinoceptors, is responsible for further efflux of purines after ischemic-like period. It seems likely that NO is also involved in the regulation of purine outflow, since inhibition of NO production attenuated the []purine outflow, evoked by ischemic-like conditions, while exogenous NO facilitated the basal outflow.Brain Research 04/1999; · 2.88 Impact Factor
Article: Local regulation of vasopressin and oxytocin secretion by extracellular ATP in the isolated posterior lobe of the rat hypophysis.[Show abstract] [Hide abstract]
ABSTRACT: It is now widely accepted that ATP functions as a signalling substance in the nervous system. The presence of P2 receptors mediating the action of extracellular ATP in brain regions involved in hormonal regulation raises the possibility that a similar role for ATP might also exist in the neuroendocrine system. In this study, the release from the rat isolated neurohypophysis preparation of endogenous ATP, oxytocin and vasopressin (AVP) were measured simultaneously using luciferin-luciferase and RIA techniques. After 70 min preperfusion, electrical field stimulation caused a rapid increase in the amount of ATP in the effluent and the release of AVP and oxytocin also increased stimulation-dependently. Inhibition of voltage-dependent Na+ channels by tetrodotoxin (1 microM) reduced the stimulation-evoked release of AVP and oxytocin; however, the evoked release of ATP remained unaffected. The effect of endogenous ATP on the hormone secretion was tested by suramin (300 microM), the P2 receptor antagonist. Suramin significantly increased the release of AVP, and the release of oxytocin was also enhanced. ATP, when applied to the superfusing medium, decreased the release of AVP, but not that of oxytocin, and its effect was prevented by suramin. ATP (60 nmol), added to the tissues, was readily decomposed to ADP, AMP and adenosine measured by HPLC combined with ultraviolet light detection, and the kinetic parameters of the enzymes responsible for inactivation of ATP (ectoATPase and ecto5'-nucleotidase) were also determined (Km=264+/-2.7 and 334+/-165 microM and vmax=6.7+/-1.1 and 2.54+/-0.24 nmol/min per preparation (n=3) for ectoATPase and ecto5'-nucleotidase respectively). Taken together, our data demonstrate the stimulation-dependent release, P2 receptor-mediated action and extracellular metabolism of endogenous ATP in the posterior lobe of the hypophysis and indicate its role, as a paracrine regulator, in the local control of hormone secretion.Journal of Endocrinology 04/1999; 160(3):343-50. · 4.06 Impact Factor
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ABSTRACT: Using histochemical and immunocytochemical methods, cholinergic nerve fibres were demonstrated in the rat adrenal cortex, primarily in the capsule and zona glomerulosa, and in the medulla. Some terminated among the glomerulosa cells or around blood vessels. Occasional fibres were also seen in the fasciculata, ending in islets of chromaffin tissue without ramifications on cortical cells. To clarify the role of cholinergic innervation, a microvolume perifusion system was used to study steroid production by the rat adrenal capsule-glomerulosa. Acetylcholine (ACh) itself had no reproducible effects; however, since variable amounts of endogenous ACh were present, the actions of antagonists were also studied. The M1 muscarinic receptor antagonist pirenzepine (10 and 100 microM) stimulated aldosterone secretion. This stimulation was abolished by co-incubation with carbachol, the M1 agonist McN A-343 and by atropine. We found that the action of pirenzepine was blocked by nifedipine (Ca2+ channel blocker), suggesting that pirenzepine (through release of endogenous ACh) provides an acute stimulus by enhancing Ca2+ inflow. Hemicholine, a choline uptake blocker, reduced the stimulatory effect of pirenzepine on steroid secretion, confirming that stimulation was of neural origin. Neither the non-selective muscarinic receptor antagonist atropine, the selective M1-M3 muscarinic receptor antagonist 4-DAMP, nor the selective M2 muscarinic receptor antagonist methoctramine influenced aldosterone output. Receptor-binding studies revealed the existence of M3 receptors in capsule-glomerulosa homogenates. We conclude that pirenzepine acts on presynaptic M1 autoreceptors to increase spontaneous ACh release from varicose axon terminals that lie in close proximity to the glomerulosa cells. In turn ACh may thus stimulate steroidogenesis acutely through M3 receptors. These results support the concept of a direct cholinergic influence on zona glomerulosa function in the rat.Journal of Endocrinology 06/1998; 157(2):305-15. · 4.06 Impact Factor
Article: Local non-synaptic modulation of aldosterone production by catecholamines and ATP in rat: implications for a direct neuronal fine tuning.[Show abstract] [Hide abstract]
ABSTRACT: In addition to hypophyseal control, steroid synthesis and secretion in the adrenal cortex is also under direct local neural modulation. We obtained morphological and neurochemical evidence that a substantial proportion of the noradrenergic nerve endings lie in close proximity to zona glomerulosa cells without making synaptic contact, thus providing evidence for a direct local modulatory role of catecholamines in steroid secretion. These noradrenergic neurones, like other noradrenergic neurones in the central nervous system, are able to take up dopamine (DA), convert it partly into noradrenaline (NA) and to release both NA and DA together with the co-transmitter ATP when neuronal activity drives them to do so. These catecholamines and ATP may reach zona glomerulosa cells via diffusion in a paracrine way and modulate the synthesis of aldosterone. The presence of ecto-Ca-ATPases, enzymes that may terminate the effect of ATP, was demonstrated around the nerve profiles indicating that not only ATP but its metabolites (ADP, AMP, adenosine) can also influence the production of aldosterone. These data strongly support the possibility of a paracrine, non-synaptic modulatory role of catecholamines and ATP in the regulation of adrenocortical steroid secretion.Hormone and Metabolic Research 01/1998; 30(6-7):323-8. · 2.15 Impact Factor
Article: Studies on the release and extracellular metabolism of endogenous ATP in rat superior cervical ganglion: support for neurotransmitter role of ATP.[Show abstract] [Hide abstract]
ABSTRACT: The release of endogenous ATP, measured by the luciferin-luciferase assay, and the release of [3H]acetylcholine from the isolated superior cervical ganglion of the rat loaded with [3H]choline were studied simultaneously. Electrical field stimulation enhanced the release of endogenous ATP and acetylcholine in a [Ca2+]o-dependent manner. The Na+ channel blocker, tetrodotoxin (1 microM) inhibited the stimulation-evoked release of endogenous ATP and of [3H]acetylcholine, but did not change the resting release. The release of ATP was dependent on the frequency of stimulation between 2 and 10 Hz. when the number of shocks was kept constant (360 shocks), while acetylcholine was not released in a frequency-dependent fashion. Ten days after cutting of the preganglionic nerve of the superior cervical ganglion the stimulation-evoked release of acetylcholine and ATP was abolished and the uptake of [3H]choline was significantly reduced but not inhibited. Hexamethonium, (100 microM) a nicotinic acetylcholine receptor antagonist, significantly reduced the release of both acetylcholine and ATP, indicating a positive feedback modulation of ACh and ATP release. 8-Cyclopentyl-1,3-dipropylxanthine (10 nM), the selective A1-adenosine receptor antagonist exhibited similar effect on the release of ATP and acetylcholine: both of them were augmented, showing that the stimulation-evoked release of ATP and acetylcholine are under the inhibitory control of A1-adenosine receptors. When the temperature was reduced to 7 degrees C to inhibit carrier-mediated processes, the resting and stimulated release of acetylcholine was not changed. Conversely, the release of ATP in response to stimulation was reduced by 79.9 +/- 5.6%, and the basal release was also almost completely blocked. Carbamylcholine by itself was able to release ATP, but not acetylcholine, in a hexamethonium-inhibitable manner, even from ganglia whose preganglionic nerve had been cut 10 days prior to experiments, suggesting that ATP release can occur in response to nicotinic receptor stimulation of postsynaptic cells. The breakdown of ATP or AMP by superior cervical ganglion was measured by high performance liquid chromatography combined with UV detection. ATP and AMP, added to the tissues, were readily decomposed: the Km (apparent Michaelis constant) and Vmax (apparent maximal velocity) were 475 +/- 24 microM and 3.50 +/- 0.18 nmol/min per mg for ectoATPase and 1550 +/- 120 microM and 14.5 +/- 0.9 nmol/min per mg tissue for 5'-nucleotidase. In addition, by using electron microscopic enzyme histochemistry, the presence of ectoATPase was also shown in the superior cervical ganglion. It is concluded that endogenous ATP and acetylcholine are released simultaneously in response to stimulation of preganglionic nerve terminals in the superior cervical ganglion in a [Ca2+]o-dependent, tetrodotoxin-sensitive manner and is metabolized by ectoenzymes present in the tissue. The dissociation of the release of ATP and acetylcholine at different stimulation frequencies and temperatures shows that the release-ratio of acetylcholine and ATP can vary upon the condition of stimulation: this can reflect either the different composition of synaptic vesicles in the preganglionic nerve terminals or a significant contribution of non-exocytotic, carrier-mediated type of release of ATP to the bulk release.Neuroscience 09/1997; 79(3):893-903. · 3.12 Impact Factor
Article: ATP and [3H]noradrenaline release and the presence of ecto-Ca(2+)-ATPases in the capsule-glomerulosa fraction of the rat adrenal gland.[Show abstract] [Hide abstract]
ABSTRACT: Both [3H]noradrenaline ([3H]NA) and ATP were released in response to supramaximal electric field stimulation in superfused rat adrenal capsule-glomerulosa preparations. The voltage-dependent potassium channel blocker 4-aminopyridine enhanced, while the ATP-sensitive potassium channel blocker glibenclamide failed to affect the stimulation-evoked release of [3H]NA. The selective alpha 2-adrenoceptor antagonist CH-38083 enhanced the evoked release of [3H]NA while the P2 receptor agonist ATP and alpha, beta-methylene-ATP failed to affect it. Neither the adenosine A1 receptor agonist N6-cyclopentyl-adenosine (CPA) nor the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) influenced the stimulation-evoked [3H]NA release. The data showed that ATP was released from capsule-glomerulosa preparations in response to field stimulation together with but independently from [3H]NA, and that the local noradrenergic varicose axon terminals are not equipped with purinoceptors sensitive to ATP and/or adenosine. High concentrations of ATP also stimulated steroid hormone secretion in vitro, and thus may have a physiological role in this tissue. The presence of ecto-Ca(2+)-ATPases, enzymes able to terminate the effect of ATP, was demonstrated around the nerve profiles at the border of the capsule and zona glomerulosa tissue.Journal of Endocrinology 05/1997; 153(1):105-14. · 4.06 Impact Factor
Article: Neurochemical evidence of heterogeneity of presynaptic and somatodendritic nicotinic acetylcholine receptors.Annals of the New York Academy of Sciences 06/1995; 757:84-99. · 4.38 Impact Factor
Top Journals
Egis Gyógyszergyár Nyrt.Budapeŝto, Budapest, Hungary
Acheuron Hungary Ltd.Algyő, Csongrád, Hungary
University of Szeged
Szeged, Csongrad megye, Hungary
- Department of Public Health
Hungarian Academy of Sciences
Budapest, Budapest fovaros, Hungary
- Department of Pharmacology


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BOSTON Ś Listen carefully to what the worldÆs climate experts are saying.
TheirĀlatest report on global climate changeĀis Ś quite literally Ś a list of climatic calamities.
HereÆs a sample:
ōWarming of the climate system is unequivocal, and since the 1950s many of the observed changes areĀunprecedented over decades to millennia.ö
ōEach of the last three decades has been successively warmer at the EarthÆs surface than any preceding decade since 1850. In the Northern Hemisphere, 1983¢2012 was likelyĀthe warmest 30-year period of the last 1,400 years.ö
ōOver the last two decades, the Greenland and Antarctic ice sheets have been losing mass,glaciers have continued to shrink almost worldwide.ö
ōThe rate of sea level rise since the mid-19th century has beenĀlarger than the mean rate during the previous two millennia.ö
ōThe atmospheric concentrations of carbon dioxide (CO2), methane, and nitrous oxide haveĀincreased to levels unprecedented in at least the last 800,000 years.ö
But forget the science. Forget the politics.
For multitudes around the world today, calamity has already arrived. Drastic climate changes have sparked economic dislocation, political discord, and even death. And itÆs happening right now, in nearly every corner of the planet.
Above all, climate change Ś and what it means for life on Earth Ś is prompting fear and unease across the world:
Calamity Calling: WhatÆs your biggest fear?ĀfromĀGlobalPostĀonĀVimeo.
To help understand the breadth, depth and scope of climate change Ś and what it means to the people living through it Ś GlobalPostÆs award-winning team of correspondents and videographers spent much of 2013 investigating this global phenomenon, assessing the environmental, economic and political costs.
Their reporting mirrors the dire warnings of climate experts.
Our team has traveled to the Amazon rainforest, where scientists are struggling to understand what human activity is doing to the worldÆs most complex ecosystem.
WeÆve scaled the Himalayan mountains of northernĀIndia, where rapidly melting ice and shifting rains are triggering deadly flash floods.
WeÆve explored the ice fields of Greenland, Alaska andĀCanadaĀwhere glacial melting is altering landscapes and threatening traditional ways of life.
WeÆve traveled to the southern African island of Madagascar where the worldÆs only lemurs are disappearing amid a host of severe climate changes.
WeÆve trekked across the North African country of Mali where desertification is contributing to rising political instability, including the growth of Islamic terrorist groups like Al Qaeda in the Maghreb.
WeÆve been to the Gobi, a vast and expanding desert across Mongolia andĀChinaĀthatÆs hurtling sand and dust into the atmosphere, which then mixes with polluted skies to create toxic clouds that are choking some of AsiaÆs most-populous cities.
WeÆve also examined the impact of climate change on coastal regions and sea life, including the disappearing beaches of theĀMexicanĀtourist mecca of Cancun and the dying coral reefs off the coast of Belize.
And weÆve journeyed across the Great Plains of theĀUnited States, where increasingly extreme weather now threatens one of the worldÆs most fertile agricultural regions.
Over the next 10 weeks weÆll be featuring these stories and videos Ś one every week Ś in a series weÆve named Calamity Calling. We hope youÆll follow along each week, and share these stories and videos widely.
As our reporting will illustrate, there is no bigger story on the planet. And none that so dramatically shows that, yes, we are all in this together.


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Marines Airsoft SSO1 Airsoft Shotgun 6mm Spring Pump Action Polymer Tan and Black
Product #: 217051 Marines #: MCSS01 UPC #: 028478135437
Airsoft guns are required to have the tip (1/4") of the barrel permanently colored blaze orange.
Product Information
The Marines Airsoft SS01 Airsoft Shotgun is one of the most fun airsoft guns you will ever shoot. The pump action delivers 6mm BBs at a velocity of 350 fps, as fast as you can pump the gun. The SS01 holds 24 BBs a magazine, and also features a 490-round reservoir for fast reloads. The adjustable buttstock is perfect for any size shooter, and can also be collapsed to make the shotgun more compact in tight spaces. Pick up a Marines SS01 Shotgun today for your next airsoft battle.
Technical Information
Technical Information
- Caliber: 6mm
- Weight: 2.7 lbs
- Overall Length: 26.75"
- Barrel Length: N/A
- Length of Pull: N/A
- Ammunition: 6mm BBs
- Trigger Pull: N/A
- Trigger Type: Single Stage
- Safety: Manual
- Max Muzzle Velocity: 350 fps
- Action: Pump
- Single Shot/Repeater: Repeater
- Cocking Effort: N/A
- Power Source: Spring
- Barrel Type: Smooth Bore
- Front Sight: None
- Rear Sight: None
- Optics Compatible: Picatinny Rail
Delivery Information
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text: 1 drape something around/over/across, etc. something to hang clothes, materials, etc. loosely on someone or somethingShe had a shawl draped around her shoulders.He draped his coat over the back of the chair.She draped a cover over the old sofa.2 drape someone/something in/with something to cover or decorate someone or something with materialwalls draped in ivy3 drape something around/over, etc. something to allow part of your body to rest on something in a relaxed wayHis arm was draped casually around her shoulders.


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How To Hold A Guitar Pick
Knowing how to hold a guitar pick is an important step in learning how to play the guitar. If you hold a guitar pick incorrectly for a long period of time, you can accidentally drop and lose the pick during an important show, or you might even hurt your wrist from holding a guitar pick in a funny position. Luckily, there are easy steps to take to avoid all of this hassle and learn how to correctly hold your pick.
To learn how to hold a guitar pick you will need:
- a guitar pick
- strong hands
- a guitar
- practice
- Hold the guitar pick in the hand you play with: If you are right-handed, put the pick in your right hand. If you are left-handed, do the opposite.
- Hold the guitar pick comfortably between the thumb and either the index or middle finger: These are your two main ways of doing it, and it comes down to what is comfortable to you. It's sort of like how different people hold pencils differently. It has to do with how you learned, and how you feel comfortable doing it. Whichever you choose, there are some ways not to hold a guitar pick.
- Don't hold it using the ring or pinky fingers: It will be much harder to grip, and might cramp your hand after a while.
- Don't put it between the knuckles of your index and middle fingers: You won't be able to control the movement of the pick as much, and it will most likely slip between your fingers, and fall onto the floor or into the sound hole. This can be frustrating in the middle of a song, and even worse in the middle of a performance.
- Extend the rest of your fingers: It's best to have the rest of your fingers extended when holding a guitar pick. This allows for more advanced technique later on when you use the rest of your fingers to play with the sound of the guitar.
Most importantly, when figuring out how you hold a guitar pick, make sure that you feel comfortable doing so. If you play a show or give a performance, you'll be playing the guitar for an extended period of time, and it's no fun having to do something that feels uncomfortable for that long.
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4" x 6-5/8" DirectVent Pro Counter Flashing
DirectVent Pro is a unitized, coaxial venting system designed for use with direct vent gas or propane stoves, heaters, and fireplaces. Stunning design and Engineered Excellence utilizing state-off-the-art manufacturing. DirectVent pro features tight inner connections for a superb performance, with no gaskets or sealants required (unless specified by the manufacturer). Low-profile locks and no hems or beads allow for a beautiful product that looks elegant in any interior.
- Prevents water intrusion into stucco-sided homes.
- Allows the installer to apply siding material (i.e.: stucco, brick, etc) over the flanges up to the sides of the flashing for a water tight seal.
- Kit includes four pieces.
- Sized for horizontal cap ONLY.
Additional DuraVent Links
- View Manufacturer Warranty
- Shop All DuraVent Products
- Shop All DuraVent 4" x 6-5/8" DirectVent Pro Collection Products
Our SKU: DuraVent 46DVA-CF
This product is listed under the following manufacturer number(s):
- DuraVent 46DVA-CF
*Denotes a finish or option that has been discontinued
Manufacturer Resources
Installation Resource Center
Whether you are installing the product yourself or hiring a professional, our installation Resource Center has everything you need to get your project done. Visit the Installation Resource Center to get started.


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free shippingon most orders over $49*
Get 3% Backwith AllModern rewards
|The Emsa collection from Freiling offers classy, sophisticated designs that rank high on functionality and style. The collection has a hard glass liner and is 100% leak proof, making it the perfect choice to carry when travelling. It is available in an array of attractive colours for you to choose from as per your choice.


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Sounds Like: Simon & Garfunkel, They Might Be Giants, The Beatles, Dr. Spencer Reid
Bio: "In the darkness something was happening at last. A voice had begun to sing. It was very far away . . . . Its lower notes were deep enough to be the voice of the earth herself. There were no words. There was hardly even a tune. But it was, beyond comparison, the most beautiful noise he had ever h... See Full BioMore Info
Sep 7
"Our Casablanca Lounge is a small intimate piano bar atmosphere located on the first floor next to [the lobby of the Lani Kai Island Resort]."
Aug 10
"Nemo's is your first choice for casual dining on Fort Myers Beach. Our little slice of paradise is right on the beach just steps away from the pier. You can spend the day with your toes in the sand and know that Nemo's is right there for a cold beer or a cocktail and our award winning food to while away the day."
Jun 15
"[Olympia is] conveniently the closest bar to the FGCU campus. Open a number of nights a week including coin nights, ladies night and college night, this bar is a great place to meet up for the 21+ age group.
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"Florida Gulf Coast University Theatre Lab and Footsteps to the Future collaborate to present 'Suit My Heart,' an original, ensemble created-performance."
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"Fiddler's Green Irish Pub has been in Winter Park, Florida - Since 1996."
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What type of worm is this?
Probably A. polyanthemos, but maybe A. hispida?
Found at Bluff Lake in water sample
Found curled up in lead litter along the waterline of Bluff Lake.
Classification uncertain
Found near the waterline of Bluff Lake. Exact classification unknown.
Found in a crevasse of a partially submerged log.
Classification uncertain, based on size, color, and nest appearance.
Unknown larva, possibly Lepidoptera or Coleoptera.
Found in huge abundance, multiple specimens per square meter. Would occasionally skitter across the water surface
Found on the bottom of a partially submerged chunk of bark. Others were seen completely submerged, crawling on the substrate.
Say's Phoebe
Adams County, Colorado
White-crowned Sparrow
Adams County, Colorado
Mule Deer
Adams County, Colorado
Black-tailed Prairie Dog
Adams County, Colorado


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New Music: Kid Ink "OG" Prod. by Young Chop
Kid Ink is on his super grind dropping a leak off his upcoming "RocketShipShawty" mixtape which will be available on November 21st...just in time for Turkey Day. So listen and zone out to ya boy with the Bat Gang behind him.


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5″ to 14″ 'Texas' Vertical Deep Well Turbine Bowl Submersible Pumps
Support Documents
You will need Acrobat Reader to view these documents. Click the button to download the free plugin
Features and Benefits
- Discharge Bowl: Several discharge sizes available
- Discharge Bearing: Extra Long sealed top bronze bearing ensure shaft alignment and stabilization for extended life.
- Intermediate Bowl: Class 30 cast iron. Glass coating on 6″ and larger bowls for maximum efficiency and abrasion resistance.
- Intermediate Bearings: Available in either nolead bronze or rubber.
- Impellers: Designed for maximum efficiency with a wide range of hydraulic coverage. Made of low zinc and no lead material suitable for drinking water applications.
- Taperlock: Accurately machined to ensure positive locking of the impeller to the pump shaft.
- Upthrust Collar: Designed with extra margin of safety against momentary upthrust at start up.
- Suction Adapter: Designed to ensure proper pump/motor alignment. Open area permits easy excess to pump/motor coupling. Casting made of ductile iron for increased strength.
- Pump to Motor Coupling: Stainless steel coupling accurately machined for perfect alignment, balance and power transmission.
- Pump Shaft: 100,000 PSI high tensile type 416 stainless steel provides strength and corrosion resistance. Ground and polished for smooth bearing surface.
- Powered for Continuous Operation: All horsepower ratings are within the working limits of the motor and pump can be operated continuously without fear of damage to the motor.
- Turbine.


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1992 Cadillac Allante Roadster - 4.5 liter V8, automatic, all power: steering, disc brakes, seats, windows, locks & trunk, leather upholstery, AM/FM CD stereo, digital instruments, alloy wheels, cruise control, climate control - ONLY 17,000 Original Miles! - Very Clean & Well Kept - Good Service History - Needs Some Minor Service Work To Be Perfect - WAS ASKING $12,500 - NOW ASKING $9,995 or OFFER
Our 75-100 picture package is available by request. - We are glad to assist with shipping anywhere in the US or worldwide. - Financing is available directly through JJBest.com or WoodsideCredit.com - Appointments for inspections are recommended. - Thanks for looking! - We look forward to hearing from you soon!
Price: $9,995 obo


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Byte Night 2014 has raised £1 million! Thank you for all your support and donations, you are helping us to change even more lives and keep dreams alive.
Thank you to our 2014 sleepers. Over 1300 people slept out with us across the UK on the 3rd October and together you have raised £1 million!
Get involved as an individual or as part of a team of up to five sleepers. Just complete our short form to register today!Register your team today
We have eight Byte Night events due to take place around the country on Friday 2nd October 2015. Why not find your nearest location.View our event locations
For 2014, we've set our sights high. With eight Byte Night events around the country, we're hoping to raise in excess of £1.2 million.Find out more
Byte Night is now the leading charity event for individuals and teams from the IT, technology and business sectors. Last year, we raised an amazing £1,070,000 thanks to hundreds of people who chose to sleep-out for the night.
Congratulations and a huge thank you to all our sleepers and supporters involved in Byte Night 2014. You helped us make this year's event a record breaking Byte Night with over 1300 sleepers from the IT and Business Industry sleeping-out to raise funds to prevent youth homelessness. Your dedication and fundraising efforts have helped us raise £1 million so far and the donations continue to flood in! Thanks to your support Action for Children has helped thousands more young people to build better lives by providing essential support, accommodation, education and training.


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Under the Sea Novelty Favors
Under the Sea Novelty Favors Make Fun Keepsakes
Send guests home from your under the sea theme party with a unique keepsake. Our under the sea novelty favors feature an assortment of toys and fun items for guests of all ages. Choose a novelty favor or one of our under the sea wearables to add a little fun to your favor bags.
Plush FishYour Price: $2.99 each
Turtle Sun CatcherYour Price: $0.20 each
Coral Reef Personalized NotepadsYour Price: $1.99 each
Color A SharkYour Price: $2.99 each
Color An OctopusYour Price: $6.99 each
Plastic Toy TurtlesYour Price: $4.99 pkg/12
Under The Sea VisorYour Price: $12.99 pkg/12
Tropical Ocean Personalized NotepadsYour Price: $1.99 each
Assorted Plastic FishYour Price: $5.99 pkg/5
Fish BowlYour Price: $1.49 each
Paintable Fish CraftStarting at: $0.49 each
Ocean Preppy Girl 1st Birthday HatYour Price: $0.63 pkg/8
Plush SharkYour Price: $7.99 each
Create-A Reflections MirrorYour Price: $1.99 each
Blue Tin PailYour Price: $2.99 each
Create-A NotebookYour Price: $1.99 each
Create-A BubbleYour Price: $1.19 each
Create-A Square MagnetStarting at: $1.49 each
Under the Sea Themed Personalized LotionYour Price: $0.99 each
Plastic Fish BowlYour Price: $1.49 each
Imitation Sea Shell BraceletsYour Price: $2.99 dozen
Large Clear Ornament BallYour Price: $2.49 each
Under the Sea Novelty Favors & Favor Tips
Choose from our selection of ocean novelty favors and your guests will take home fun or humorous favors that remind them of the good times at your under the sea party. Kids love the plush sharks which they can play with a the party. Keep them further entertained with an shark favor pack. Older guests will love displaying an atlantis photo cube on their desk. They can even add photos from your party. Package your party favors in themed under the sea favor bags so that your party keepsakes coordinate with all your under the sea party supplies.


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Search Results for compact binoculars fold
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Showing all 5 results.
Kruger Optical KT610 Compact Tripod 65309
this Kruger Optical Tripod. Specifications for Kruger Optical Compact Tripod: Folded height (inches): ... Kruger Optical KT610 Compact Tripods are lightweight and durable enough to carry around unlike ... a more full size tripod. The KT610 Compact Tripod by Kruger Optical will provide support for not only ... a camera and binoculars, but also a spotting scope. Reduction of camera shake and more precise ... of Kruger Optical 65309 Compact Tripod Reduces camera shake Durable metal construction Package Content Kruger Optical KT610 Compact Tripod 65309...
Vortex Summit SS Tripod ST-4
Vortex Summit SS Tripod ST-4 is a super-compact, super-stable tripod that's easy to collapse ... into just the right position for your observation. The Vortex Summit Super Short Binocular Tripod ... plate allows you to remove and install spotting scopes and binoculars at a moment's notice. Though ... it's compact, the Summit SS is also stable, with rubber-tipped legs and a balance hook for holding ... extra weight during blustery days. To further improve the compact height of the tripod, Vortex Optics ... Sections: 5 Leg Angles: 3 Folded Height: 14" Folded Width: 3.8" Weight: 1.8 lbs Material: ... Anodized aluminum Features of Vortex Summit Super Short Ball Head Tripod: Incredibly compact...
Vortex Summit XLT Tripod ST-3
of 64.1 inches but collapse quickly and compactly for easy storage and transportation. Twist leg locks ... of binoculars or spotting scopes. When the wind starts to blow, you don't have to worry about your ... binoculars falling over; Vortex Optics has equipped the Summit XLT with a balance hook to hold extra weight ... for an even more compact collapse of the tripod, making it easy to carry in and out of the wilderness. ... 64.1" Leg Sections: 5 Multiple Leg Angles: 3 Folded Height: 18.1" Folded Width: 4" ... and collapse, ideal for mounting binoculars and spotting scopes 5-section legs allow for a maximum ... height with a compact collapse length Lightweight design built for ease of carry Twist leg locks reduce...
Kruger Optical KT690 Mid-Size Tripod 65310
Kruger Optical KT690 Mid-Size Tripod is lightweight and durable with a much more extended folded ... height than a compact tripod. The KT690 Mid Size Tripod by Kruger Optical will provide support ... for not only a camera and binoculars, but also a spotting scope. Reduction of camera shake and more ... this Kruger Optical Tripod. Specifications for Kruger Optical KT690 Mid-Size Tripod: Folded...
Yukon Telescopic Universal Tripod Kit 29013
the Scout 30x, the Yukon 20-50x50, the Newtonian Reflector Binocular, and units equipped for standard ... of the mounted device, lbs/ kg: 4.5 / 2 Length folded, in./mm.: 13.7 ... Kit 29013: Pinhead lever Compact Sturdy aluminum alloy construction Lightweight (only 12 oz.) Car...
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Mississauga, ON, Canada < change city >
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Jewelry (16)
Ceremony Sites (240)
Reception Sites (170)
See All Vendors >
Lucy and Jason 's Wedding
Ceremony at Merciful Redeemer Parish
Reception at Pavilion Royale
"We had a great wedding one month ago on November 5, 2011. Our ceremony w..."
Erin and Lee's Wedding
Ceremony at Mississauga Convention Centre, Salon E
Reception at Mississauga Convention Centre, Salon E
Christabelle and Jason's Wedding
Ceremony at Christ The King-Roman Catholic Cristo Rei
Mississauga Wedding In November
Ceremony at Mississauga Convention Center
Our Wedding
Ceremony at Sri Guru Singh Sabha Malton Gurdwara
Reception at Bombay Palace Banquet Hall
Jennifer and Smith's Wedding
Ceremony at Glenerin Inn
Alice Maya and Danny 's Wedding
Ceremony at Saint Maximilian Kolbe Parish
Reception at Grand Metropolitan of Mississauga
Hollie and Shawn's Wedding
"Niagara was amazing. Luckily we were married during the Festival of Ligh..."
Antoinette and Christopher's Wedding
Ceremony at Maple Banquet Hall
"Our wedding was amazing. The staff handled everything is dignity and class. The ceremony was set up beautiful, and ..."
Oakville Wedding In November
Ceremony at St Andrew's Church
Reception at Oakville Conference & Banquet Centre


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Mango Lassi
Summer is no fun without mangoes. Mango Lassi is a cold drink consisting of sweetened kesar mango pulp mixed with yoghurt, cream, or ice cream.
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Lassi Recipe
Lassi Recipe
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Lassi Drink
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S: Total Length: 77cm, Waist: 83cm, Hem: 95cm, Shoulder Width: 38cm, Sleeve Length: 59cm, Sleeve Biceps: 28.5cm, Cuff: 20cm, Bust: 88cm, Front Neckline Length: 38cm,
M: Total Length: 79cm, Waist: 87cm, Hem: 99cm, Shoulder Width: 39cm, Sleeve Length: 59cm, Sleeve Biceps: 30.1cm, Cuff: 21cm, Bust: 92cm, Front Neckline Length: 38.6cm,
L: Total Length: 81cm, Waist: 91cm, Hem: 103cm, Shoulder Width: 40cm, Sleeve Length: 59cm, Sleeve Biceps: 31.7cm, Cuff: 22cm, Bust: 96cm, Front Neckline Length: 39.2cm,
|Material & Care Information
|51%Cotton + 49%Polyester
|Wash care:
|Hand Wash, Machine Wash
|More Information
|Catalog No.:
Established in Shanghai in 2007, Dabuwawa specializes in women's apparel that adheres to a classically feminine design, and is the sister brand to Pink Doll. Dabuwawa primarily uses natural fabrics such as silk and cotton as well as Spandex and Lycra to create striking styles. YesStyle is an authorized retailer of Dabuwawa.


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Chase Headley had a long day after being traded to the New York Yankees from the San Diego Padres prior to Tuesday night's game, but the 30-year-old made it just in time to join his new team and make a very special impact.
The now beard-less Headley broke a 1-1 tie in the 14th inning when he ripped a single to left-center field that scored Brian Roberts for the game-winner versus the Texas Rangers.
The video is courtesy of MLB.com:
The game remained tied at zero until the 13th inning when both teams were finally able to post a run on the scoreboard.
Roberts' one-out double in the 14th got the ball rolling for New York to win the game and Headley sealed the deal after getting into the game as a pinch-hitter earlier on.
What a great way to start his career in pinstripes and Headley is quickly discovering how great it can be when you do big things in New York. It didn't take long at all for Headley to endear himself to Yankees fans.
Now the important part is keeping it up as the Yanks badly need some help on offense and so far Headley is giving them just that. Still a long way to go, though.
- Be sure to like Yankees 101 on Facebook, follow Yankees 101 on Twitter& +1 Yankees 101 on Google+
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Seeing your team play in the SuperBowl is priceless. Watching the SuperBowl live in the stands for $1 per week is beyond priceless. Find out how at TicketScore.com, the future of Championship Tickets.
Tags: Baseball, Chase Headley, MLB, New York, New York Yankees, San Diego Padres
Related posts
- MLB Trade Rumors: New York Yankees Aren't Strongly Pursuing San Diego Padres 3B Chase Headley
- MLB Trade Deadline: New York Yankees Trading for Chase Headley was Right Move to Make
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Short URL: http://sport-ne.ws/1dp0


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That sounds like the best waterpark day ever. Being that it is now below freezing here I would kill for that. Can't believe i've fallen so behind on your blog, at least this insomnia should help me catch up! Hope you're coping with the quakes in NZ ok at the moment too.
What is below the trapdoor
Trip Start Feb 26, 2010
371Trip End Feb 26, 2011
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We woke at about 7am to find our 'downloading' session hadn't gone well. Then had breakfast on the porch of fried eggs on toast with fruit and tea (I don't know what we are going to do when we get home without a porch to have breako on we are getting quite accustomed to it). We decided to splash out literally and head to the water park called Waterbom – the largest it Bali which just so happens to be about a fifteen minute walk from where we are staying. When you're trying to spend no money it often falls to the wayside and you end up drinking which isn't all that cheap in Indonesia. We arrived shortly after opening time around 9.15am to ensure we got full value and probably forked out the whole daily budget (accommodation included) on our entry fee
At lunch we managed to argue a pass out so we could find cheaper food elsewhere and ended up having a quick wander around the big shopping centre in Kuta. We also found an arcade which had my favourite basketball game. All the fun of the fair for about 6 pence a go.
Heading back into the waterpark we were soon doing all the rides again but really starting to feel the pain of the constant climbing. We ended up leaving at about 17:00 hardly able to walk. As today was our 6 month anniversary of travelling we decided to head out for a few beers and get an early night before our early flight the next day we booked our taxi for 05:30 and went to find a cheap bar.
As part of our tour round we managed our final Asian book swap with a lady who looked like we had robbed her still a three for three swap with another �2 in cash seemed reasonable to me for both sides, she had said we were her only clients of the day, oh and we promised her we would exchange the books back with her if we managed to finished them (note the if!!) before we left Bali
At our final stop we ended up sitting with an Australian couple from Perth who we ended up chatting to for a little while longer than we ought to have. We were getting along great until the owner of the bar suggested it was closing time. "Closing time........" bloody hell how much have we drank and how long have we been here. As it turned out Stuart and Carol picked up the tab for all our drinks as well which they only informed us as they were leaving. Such a kind and generous thing to do, which added to a load on information about things to do in Aus. So all in all a great night, we wandered back to Fat Yogi's and Erica rang her mum, staying on the phone until almost 2am our time. We were horribly tired.


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In what has to be one of the most hype moments in a game with a long history of them, pro MvC2 players Clockw0rk and Neo went toe to toe this weekend at the West Coast Warzone tournament, each of them putting fifteen thousand dollars on the line in a truly epic money match. The match was a first to 15 wins scenario, so prepare yourself for 90 minutes of great MvC2 play, screaming commentary and a positively electric crowd. Competitive fighting game videos don't get much better than this:
Even more interesting is the fact that both players avoid the typical Magneto/Storm/Sentinel mirror matches usually seen in pro MvC2 play; Neo opts for Cyclops and his shoryuken assist while Clockw0rk sticks with his patented (and awesome to watch) Strider/Doctor Doom lockdown tactic. Even if you're not a huge MvC2 fan, the energy and excitement here is palpable (and audible), and the pro commentary from Justin Wong and other players really adds to the hype. MvC2 made it's final EVO tournament appearance last year at EVO 2010, and this insane exclamation point is a great way to send off one of the most beloved fighting games of all time and usher in the upcoming MvC3.
Jan 19, 2010
Lionzest7 - January 20, 2011 6:21 p.m.
StealthyMangos - January 20, 2011 5:29 a.m.
NocturnalRight - January 20, 2011 5:15 a.m.
5DollarFootlong - January 20, 2011 5:03 a.m.
ViolentLee - January 20, 2011 2:52 a.m.
ViolentLee - January 20, 2011 2:50 a.m.
NathanXplosion - January 20, 2011 2:15 a.m.
NightCrawler_358 - January 20, 2011 2:15 a.m.
RamenChimera - January 20, 2011 1:07 a.m.
Pillowfort - January 20, 2011 12:31 a.m.
MetalGearFlaccid - January 20, 2011 12:11 a.m.
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Jewel Carter
Why We Should Care About The Middle East Or Our Neighbor?
Recently I had a conversation with a friend and I mentioned that there are times when I feel stupid. Usually it's when I'm watching the news channels and the topic of International relations and foreign policy comes up. My friend tried to reassure me by saying that "most Americans are ignorant to the real issues in other countries" and that "I know a lot more than most". Let me tell you that getting the highest grade on a test that I still fail is no reason to celebrate.
The Good…The Bad…The Fairy Tale
Before we get into ways to get out of a bad relationship; we must first identify what one looks like. Now I'm not talking about the obvious "bad" aka "dangerous" physical and emotional abuse riddled ones that shelters are built for. I'm talking about the silent dream-killer, hope stealer, words-DO-hurt relationships.
5 Building Blocks To Consider When Making & Keeping Friends
It seems the older we get the more difficult it becomes right? Meeting people is easy, we do that every day, but what about forming a new connection, a bond with someone that we didn't know, never heard about, met by chance and hit it off with immediately?
6 Reasons Why Some People Should Never Get Married
The other day, while riding in the car with my bff/driver/business partner/baby daddy/husband I asked the question, what do you think I should blog about next? Without missing a beat and totally unrelated to our previous conversation he says "Why some people should never get married".
93 Days of Summer Quotes: Days 36-42
It's so easy to get caught up in the DRAMA of things when you do not have a clear vision of where you are going and the experiences that you want to have along the way. I've been recently tested and for a spit second, I found myself LOOKING for all the reasons and explanations to explain SOMEONE ELSE's words and behaviors.
Promote What You Love Instead Of Bashing What You Hate
Has anyone else noticed that we have become a society of "haters"? Now by "we", of course, I mean "them". Because none of "us" would set our DVR's to record those reality Housewives shows only to be able to talk about the rachet'ness of the women on them.
10 Questions To Help You Decide If You Need Or Want A Business Coach
If you've been thinking about making a major change in your life, transitioning into another job or industry, starting your first or next new business or you want a new perspective on a question or issue that you don't want to discuss with your family, friends or co-workers; securing a coach may be just the thing you need to kick start your next venture into gear.
6 Things Every Curvy Bride Should Know Before Buying That Dress
Love and dresses come in all shapes, sizes and colors. Just ask Sisters Yukia Walker and Yuneisia Harris, owners of Curvaceous Couture in Maryland. They are on a mission to help curvy women in love, look stunning on their special day.
93 Days Of Summer Quotes: Day 29-35
"In three words I can sum up everything I've learned about life: IT GOES ON." ~Robert Frost
7 Perks To Aging That No One Talks About
Before you turn the big number with a zero behind it and start feeling some type of way about "getting OLDER", you should consider the perks and plusses of getting old. Surely this will give ME something to look forward to during the next 90 days…or will it?