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Posts tagged the-adventures-of-shuggy
VVVVVV, Escape Goat star in GOG.com's 5 for $5 indie game sale
Taking a cue from the roast beef artisans at Arby's, Good Old Games is offering a 5 for $5 sale on a collection of indie games recently added to the storefront's online catalog. GOG's Super 5 Promo includes Terry Cavanagh's VVVVVV, Smudged Cat Games' Adventures of Shuggy and Gateways, MagicalTim...
Steam weekly: They Bleed Pixels, Papo & Yo, Shuggy, Waking Mars
Steam's weekly deals kicked off yesterday, but players in the US were probably too busy lounging poolside with a plate full of hamburgers to notice – and hey, Steam users outside of the US could have been doing the same thing. It's cool; we don't judge. This week's Steam deals last until J...
Bundle in a Box has Shuggy, The 4th Wall, Eversion, more for you
On this chilly, relaxing Sunday, take a break from all that lounging around and have some fun with a bundle of indie games priced at "whatever you want" – because you deserve it. The Bundle in a Box is live for eight more days and includes the following games for exactly the price you think t...
Adventures of Shuggy gets free DLC to help celebrate Halloween
The Adventures of Shuggy is gearing up for a ghoulishly good time this Halloween with a free DLC pack, 'Shuggy's Teleporting Troubles,' set to drop on October 26. 'Shuggy's Teleporting Troubles' adds 40 new singleplayer levels and a secondary teleporter that can be used alongside Shuggy's other toy...
Indie Royale celebrates Oktoberfest with six-game bundle
Indie Royale is back with a new Steam and Desura six-game bundle. The Oktoberfest bundle features Zoe Mode's Chime and all three episodes of Hector: Badge of Carnage by Telltale Games. Smudged Cat Games' The Adventures of Shuggy also makes an appearance in the bundle along with Dangerous High Sch...
Adventures of Shuggy dev shares his sad story
We love to hear about success stories like the Humble Indie Bundle, but we try to remember that there are plenty of other deserving games out there that, for whatever reason, never seem to break free of obscurity. The Adventures of Shuggy is just such a game. David Johnston, the game's creator...
XBLA in Brief: The Adventures of Shuggy
We've already posted our (favorable) review of Duels of the Planeswalkers 2012, which leaves only one other Xbox Live Arcade release this week: The Adventures of Shuggy. A puzzle platformer with old-school sensibilities, it's just a tad different from its card-based counterpart. Check out the lat...
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Featured Stories
Barely Related: The Interview didn't go well
Posted on Dec 19th 2014 8:00PM
Super Joystiq Podcast 126: Dying Light, Bloodborne, Evolve, story in games
Posted on Dec 19th 2014 1:00PM
Evolve's Wraith monster steals the show
Posted on Dec 18th 2014 8:01AM


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Water is California's most precious and natural resource. How we manage it today will affect nearly every aspect of our future.
When our state enjoys a year of abundant rain and our reservoirs are full, it is easy to think that our water supply is endless. But after three consecutive dry years, California is now experiencing a serious drought. We simply cannot afford to waste any water.
* Follow our easy tips both indoors and outdoors and start saving water every day.
* Tour the California Urban Water Conservation Council's interactive H2ouse to learn more ways to save water indoors and outdoors!

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After more than six years on Broadway, Disney's musical "Mary Poppins" is closing for good on March 3, according to sources.
The stage adaptation of the 1964 Disney film debuted at The New Amsterdam Theatre in November 2006.
It was nominated for seven Tony Awards, including Best Musical.
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Community gathers to mourn, reflect and seek healing for racial wounds.Read more »
Melody Keller, ND ('10), treats fatigue and chronic conditions in eastern Montana.Read more »
Master's programs in public health, maternal-child health and nutrition prepare students to create systemic change.Read more »
Who Are We?
A regionally accredited, globally respected institution of natural health arts and sciences, Bastyr University is improving the planet through innovative education, research and clinical service.
Reflect on your expectations, keep up with self-care, and take other steps to manage stress during a busy season.
As President Daniel K. Church, PhD, completes his final year at Bastyr, we begin the search for a new University leader.


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MyAnneArundel is an integrated mapping application that was developed to provide the County's citizens, businesses, and visitors with access to useful services and data. Please click on one of the following "Themes" and follow the subsequent instructions to launch that specific area of the application:
|Please Pardon the interuption while My Anne Arundel is under maintenance.
General Information and Crime Statistics
Find information about County Services based on an address or obtain community specfic crime statistics that are classified by incident type.
|Public Works Maps, As-Built Engineering Drawings and Survey Monuments Research and Retrieve Record Drawings and Survey Monuments.
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By acceptance of the GIS material, you agree as follows: The GIS material (the "material") is made available by Anne Arundel County, Maryland (the "County") as a public service. The material is for reference purposes only, and the County makes no representatives, warranties, or guarantees of the accuracy of the material.
THE COUNTY MAKES NO AND DISCLAIMS ALL EXPRESS AND IMPLIED WARRANTIES RELATING TO THE MATERIAL, INCLUDING WARRANTIES OF MERCHANTABILITY, INTEGRATION, TITLE, AND FITNESS FOR A PARTICULAR PURPOSE.You release the County, its agents, servants, and employees, from any and all liability related to the material or any of it, including its accuracy, availability, use, and misuse. In no event shall the County be liable for any direct, indirect, incidental, consequential, or other damages, including savings, profits, fees, costs, loss of data, or business interruption, related in any way to the material or any of it, including its accuracy, availability, use, and misuse. The material is in the public domain and may be copied without permission. Citation to the source is requested. Any errors or omissions in the material should be reported to the Anne Arundel County Office of Information Technology Geographic Information Services Group.
County Executive Owens Lifts Voluntary Evacuation Notice
Closes Emergency Operation Center
Annapolis, MD (June 28, 2006) - Anne Arundel County Executive Janet S. Owens announced the voluntary evacuation for portions of Maryland City including the Brock Bridge area has been lifted. Residents that took advantage of the shelter are back home this morning.
"All Departments worked very hard to reach our citizens and prepare them for the storm, in particular, the Police Department whose members walked door-to-door alerting residents in both English and Spanish," said County Executive Owens. "I would also like to thank the residents who took the storm seriously, listened to our suggestions, and utilized the shelter provided," she added.
The EOC was activated early Tuesday at 12:01 a.m. with the animal friendly shelter opening at the Maryland City Fire Station Number 27 Monday night.
During the storm, the Anne Arundel County Police Department walked door-to-door alerting 900 residents in both English and Spanish, that voluntary evacuations were in effect. The department also placed 800 reverse 911-calls, notifying residents of the voluntary evacuation.
At 11:00 a.m. Wednesday, June 28, the EOC reported all residents left the shelter, and it is now officially closed. As of Noon, the EOC has returned to normal operations.
Anne Arundel County, MD. 44 Calvert Street Annapolis, MD. 21401 | Telephone: (410) 222-7000 | Suggestions | Disclaimer
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"DIAMEB" LLC is a market leader in laboratory diagnosis with more than 14 years experience and is a supplier of a wide range of products for the laboratory diagnostics from leading manufacturers.
Modern methods of cancer and in urgent situations.
The company "DIAMEB" began actively preparing to participate in the forum.
The collective of LLC "DIAMEB" congratulates all of you with the Easter holidays!
On April the 14th "DIAMEB" company turned 14 years old.


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Muckdogs 19U Summer Team
Muckdogs 19U History
2012 49-20-1
2013 43-13
2014 47-16-1
2014 19U Summer Season
2014 19U Summer Stats
2014 19U Summer Season Outlook
The 2014 summer season should be an extremely competitive and fun one for the Muckdogs 19U squad. Golden Eagle Regional Park and North Valleys High and will be the three sites where the Muckdogs will play their home games. We are excited to have upgraded facilities and are hopeful this will encourage more of the top caliber teams from the western region to come play games in Northern Nevada against our club.
The Muckdogs sixty-five game summer schedule features the team playing in the sixth annual Muckdogs Memorial Day Tournament. The team will be taking a three day trip in mid June to participate in the George Molina Invitational in Orland, California. In late June the club will head to the San Mateo area to play in the Peninsula Baseball Classic. The 19U squad will play in the fifth annual Muckdogs Invitational Wood Bat 4th of July Tournament in the last week in June. This tournament has an outstanding field of teams and should bring a lot of college and professional scouts to the Northern Nevada area. The Casey Yocom Invitational will be the next tournament the 19U team plays in, with the highlight of the tournament being games played at University of Nevada. In late July the Muckdogs 19U team will play in the All World Sports World Series in Sparks, Nevada. The 19U team's regular season schedule includes games with Hard 90, NBO Kings, Sacramento Cats, Susanville Renegades, California Prospects Baseball, Alameda Black Sox, E.J.'s Sports Prospects, California Bulldogs and the Redding Tigers.
This will be the eleventh summer of the Muckdogs 19U team, and this flagship team of the organization has been a staple of preparing Muckdog players for collegiate baseball and beyond. There will be a high level of exposure for the players on the team, the players will be constantly coached and taught, and the team will have a lot of fun while playing highly competitive baseball. Make it a point to come watch the team play this upcoming summer!
2012 Model Baseball Bats are here!
Find brand new model 2012 bats from Easton, DeMarini, Slugger, and more.


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- - http://www.sportstalkflorida.com -
2013 ALDS: Rays Joe Maddon "Unlikely Playoffs Heroes"
Posted By Matthew Sardo On October 8, 2013 @ 5:55 PM In Florida News,main feature,MLB,watch now | No Comments
Tampa Bay Rays manager Joe Maddon spoke to the media Tuesday before game four of the 2013 ALDS about the unlikely playoff heroes that arise.
Article printed from : http://www.sportstalkflorida.com
URL to article: http://www.sportstalkflorida.com/2013-alds-rays-joe-maddon-unlikely-playoffs-heroes/
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Made for a friend from afar. An ambitious crash course in some of Canada's finest. More than a hundred tracks including music by Broken Social Scene, Dan Mangan, and Chromeo.
15 comments on A Crash Course in Canadia (View all)
This is amazing! Canadian music is the best, especially Quebecois stuff. I love Coeur de Pirate and it makes me very happy to hear one of her songs in a mix.
Nice! You might like my Canadian 90s Rock mix:


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As a DirecTV sub I must say that the 922 does sound pretty impressive.
man, as a D* sub I can honestly admit that I am extremely jealous....
After Dish bought Slingmedia we knew it was only a matter of time before Dish came out with a DVR with placeshifting. Looks like DIRECTV has some catching up to do.


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Found over organic detritus and decomposing vegetation, apparent water color was brown to black, low dissolved oxygen (0.42-0.75 mg/l), as was conductivity (42-43 µs) and oxygen saturation (5.3-10 %), slightly acidic pH (6.0-6.2). Five stomachs of cleared and stained specimens indicate a diet mostly composed of algae, Clorophyta, Vlothix (47.72% N, 22.72%V); also present are Cladocera, Alonella (20.45% N, 13.63% V); Clorophyta, Spirogyra (17.04%N, 9.09%V); insect parts (9.09%N, 18.18%V), dipteran larvae, Tabaridae (5.47% N, 5.47% V); Ephemeroptera, Oligoneuridae (1.13%N, 4.54%V) and unidentified digested material (27.27%V) (Ref. 84248)..
- García-Alzate, C.A., C. Román-Valencia and D.C. Taphorn 2008 Two new species of Hyphessobrycon (Pisces: Characiformes: Characidae) from Putumayo River, with keys to the Colombian Hyphessobrycon heterorhabdus-group species. Brenesia 70:33-46. (Ref. 84248) http://www.fishbase.org/references/FBRefSummary.php?id=84248&speccode=65534


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Related quotes
"Today, I will smile and tell a kid that God loves all children regardless of their skin colors ... ٩(-̮̮̃-̃)۶"
"We had expected that the fetal skin would act as a graft, and it did not. Instead we found that it acted more like a biological bandage that stimulated healing."
"What is the difference between a taxidermist and a tax collector? The taxidermist takes only your skin"


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is this SSL for OWA?? If so, I had mega issues doing the SSL cert from the Exchange console. So I did the SSL crent though IIS and this worked fine 1st time... So if the SSL is for OWA can you not do it via IIS?
Hi there
I have an annoying problem here
I create a certficate request in Exchange 2010 console
Paste the code on the ipsca website and send the request off to them
When I recieve the certificates I have been told your meant to instal l the two files below in these locations. But when I tried to install the ipsCA LEVEL 1 CA I could not install it to that location, the local computer directory was midding, so had to install it to the root of 'Imtermedicate cert authorities' Would that cause a problem?
I have had the Active Directory Cerftificate Services installed on this box before, through I might need to use it. Would that be a cause of it missing the directory?
ipsCA LEVEL 1 CA click it to install -> place all certs in following store -> tick 'show physically stores' -> Intermediciate cert authorities -> local computer
same for ipsCA GLOBAL CA ROOT but -> trusted root cert authories -> local computer
I press complete certicate in Exchange 2010 console, but after this the problem happens.
I then get this error
'the certificate for this server is invalid for exchange server usage'
Any ideas guys?
is this SSL for OWA?? If so, I had mega issues doing the SSL cert from the Exchange console. So I did the SSL crent though IIS and this worked fine 1st time... So if the SSL is for OWA can you not do it via IIS?
Yes this is for OWA
I did try creating and completing a certificate from IIS, but had the same dreaded error message
'the certificate for this server is invalid for exchange server usage'
Sorry to hijack how long did your certificate take to arrive? I ordered one first thing yesterday got an approval e-mail and still waiting on it. Thanks
About a day, requested it in the moring and get it later that evening
Guess it depends on who you go though.
I did an install in a school in Islington last month, ordered the SSL though GoDaddy, got the email to the registered email address for the domain name, clicked on the links to authorise, and got the SSL cret within about 10min. Total time. 40min max from getting the information from IIS, to getting the SSL from Godaddy, and installing it in IIS.
SSL Certificate Authority low-cost, fully-validated 38$ SSL and 276$ Wildcard Certificates
A1 SSL Certificate
When Filling out the form I selected Exchange for the server type unless im meant to select IIS 7.5?
I can only comment on the way I did the setup, I selected IIS for mine, as I coundt get the exchange one to work.
Did you manage to install the ipsCA LEVEL 1 CA cert to Intermediciate cert authorities -> local computer?
I couldnt install it to local computer ,it was not there to select, hense i just had to install it to the root of Intermediciate cert authorities instead
Maybe thats the problem? Cause it cant identifity that cert because its ibeen installed in the wrong place?
The only reason I can think why that location is not there to select is because this server was a CA (Active Directory Cerficate Services), has been removed since. Managed to install the SSL cert for our Remote Desktop Server which was not a CA (AD CS)
Gusse I will have to contact ipsca support, see what they say
Last edited by pritchardavid; 8th June 2011 at 10:40 PM.
I'm sure you need to put these certs in the computer store, if you haven't they're probably in Administrators's store and none of the exchange services can access them
How about running mmc, add a snap-in, select "certificates", select 'computer account' etc. Does that work? If so then can you then r-click the relevant store name from their instructions and import whatever cert files you've been given?
I can have another look tomorrow for you, didnt you right click 'complete cert' ? did you 'enable' it?
1. Check your cert > run Get-ExchangeCertificate |fl >c:\cert.txt from the ems and check status
2. run Enable-ExchangeCertificate certificate -services IIS in the ems
3. Confirm is it a UCC cert
4. Make sure you have put the cert in the right place
5. Check the purpose of the cert
6. What base OS are you using inclu SP, 2008 or r2?
Last edited by sukh; 9th June 2011 at 12:13 AM.
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WHAM13 - Search Results
Search Continues For Missing Sailor In Lake Ontario
Sodus Point, N.Y. – The United States Coast Guard continued to search Tuesday, for 53-year-old Scott French of Penfield.
French called his wife Saturday morning and left her a message saying it was a perfect day for sailing and not to worry.
French left from Katlynn Marine in Sodus Point around 9a.m. Saturday.
Hours later, his 32-foot sailboat "Persnickety" was found directly north of Sodus Point in Pointe Petre, Ontario.
"The boat is in fine shape, it's a nice boat," said the General Manager of Katlynn Marine, Debbie Agostinelli, "and so something odd definitely happened."
The boat was towed back to Katlynn Marine from Canada on Monday.
"He didn't leave us a float plan he just kind of did his own thing," said Agostinelli.
Not leaving a float plan wasn't out of the ordinary for French.
According to his family he usually sails 10-15 miles off shore and then turns around.
French typically doesn't sail to the Canadian side of Lake Ontario.
French is an avid sailor, according to family his father taught him to sail at a young age.


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Zaxby's to be open by end of year?
Date: June 7, 2012
by: Andrew O'Brien | Staff Writer
(Click "Like" to become a fan of the Palm Coast Observer.)
Construction on Zaxby's, a franchised chain of fast casual restaurants that sells buffalo chicken wings, chicken fingers, sandwiches and salads, will likely begin by end of summer, in Cobblestone Village, according to city officials.
Larry Torino, senior planner for the city, said the restaurant could open by the end of the year.
"At this juncture, (it's) an energetic schedule," Torino wrote Wednesday via email.
Cobblestone Village is located behind Walmart, and near the new Florida Hospital Flagler facility.
At Tuesday's City Council meeting, the plat of lot No. 2 was unanimously approved for Zaxby's.
The technical site plan is going through the approval process right now. The second part is the building permit process.
Zaxby's will be the fast-food establishment one of the lots is zoned for. The other lot is zoned for a sit-down restaurant.
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- Dec
20 Starlight Half Marathon/5K
6:00 pm
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20 A Home for the Holidays
6:00 pm
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20 Annual Christmas Celebration of the Grenadian Association of Palm Coast
6:00 pm
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27 Kwanza
12:00 pm
Gov. Rick Scott makes campaign stop in Palm Coast
Also, DeSantis makes stop in Flagler Beach.
Football teams, cheerleaders 'in the game' at PCUMC
Also, Flagler Sheriff recognizes three exemplary employees.
OUR TOWN: FPC Alumni Weekend set for Aug. 29
Also, FPRA Volusia/Flagler Chapter launches book drive for children; and Florida Ag. Museum receives bequest from former Ag. Commissioner.


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The peculiarity of contagion is rooted in the workings of emotional intelligence and our capacity to "read" others. It is a complex phenomenon quite unlike the simple monkey–see–monkey–do. Even behaviors not obviously tinged with emotion can become contagious.
Yawning is a prime example. It is so contagious that for many people just reading or thinking about it is enough to trigger a yawn. Sculpture, too. Recently my other half took me to New York's Neue Gallerie on Fifth Avenue to see the "character heads" of Franz Messerschmidt, the eighteenth–century sculptor who famously broke away from standard studio poses to capture naturalistic attitudes and postures. In no time at all I was unable to stifle a yawn. Soon everybody in the gallery was fiercely yawning in a big feedback loop.
You might think that looking at a yawner's mouth is the trigger that sets off the reflex in you. But no, covering your mouth to conceal a yawn won't keep it from spreading. It turns out that your yawn detector's hard wiring is set to capture a wire range of grimaces, stretches, and contortions that constitute the body language of yawning. Moreover, autistic children, who are deficient at reading emotional cues, yawn spontaneously and just as normally as everyone else. They are immune, however, to contagious yawning, a manifestation of their ineffective socially connection.
Now, what about the flip side where desirable feelings might become contagious? Just as laughing, crying, or indignation can spread so too can love beget love. Consider courtship for instance. Perhaps you are not taken with an admirer in the way he or she appears to be smitten with you. Despite the lack of interest, basking in another's admiration and seeing yourself in the light of another's flame can be enough inducement for you to fall in love yourself. While it is no doubt flattering to be on the receiving end, love's real reward awaits in your own awakening to it.
Should you find yourself buoyed for whatever reason why not give it away? You will discover that the results of spreading love, kindness, and goodwill around are far more pleasant than the other way around.
Follow me @Cytowic on Twitter, Like my page on Facebook or visit my Website


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Chapter 5. The Sensorimotor System
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By BENEDICT CAREY A Polish man who was paralyzed from the chest down after a knife attack several years ago is now able to get around using a walker and has recovered some sensation in his legs after receiving a novel nerve-regeneration treatment, according to a new report that has generated both hope and controversy. The case, first reported widely by the BBC and other British news outlets, has stirred as much excitement on the Internet as it has extreme caution among many experts. "It is premature at best, and at worst inappropriate, to draw any conclusions from a single patient," said Dr. Mark H. Tuszynski, director of the translational neuroscience unit at the medical school of the University of California, San Diego. That patient — identified as Darek Fidyka, 40 — is the first to recover feeling and mobility after getting the novel therapy, which involves injections of cultured cells at the site of the injury and tissue grafts, the report said. The techniques have shown some promise in animal studies. But the medical team, led by Polish and English doctors, also emphasized that the results would "have to be confirmed in a larger group of patients sustaining similar types of spinal injury" before the treatment could be considered truly effective. The case report was published in the journal Cell Transplantation. The history of spinal injury treatment is studded with false hope and miracle recoveries that could never be replicated, experts said. In previous studies, scientists experimented with some of the same methods used on Mr. Fidyka, with disappointing results. © 2014 The New York Times Company
Keyword: Regeneration; Stem Cells
Link ID: 20230 - Posted: 10.22.2014
By Fergus Walsh Medical correspondent A paralysed man has been able to walk again after a pioneering therapy that involved transplanting cells from his nasal cavity into his spinal cord. Darek Fidyka, who was paralysed from the chest down in a knife attack in 2010, can now walk using a frame. The treatment, a world first, was carried out by surgeons in Poland in collaboration with scientists in London. Prof Wagih El Masri Consultant spinal injuries surgeon Details of the research are published in the journal Cell Transplantation. BBC One's Panorama programme had unique access to the project and spent a year charting the patient's rehabilitation. Darek Fidyka, 40, from Poland, was paralysed after being stabbed repeatedly in the back in the 2010 attack. He said walking again - with the support of a frame - was "an incredible feeling", adding: "When you can't feel almost half your body, you are helpless, but when it starts coming back it's like you were born again." He said what had been achieved was "more impressive than man walking on the moon". UK research team leader Prof Geoff Raisman: Paralysis treatment "has vast potential" The treatment used olfactory ensheathing cells (OECs) - specialist cells that form part of the sense of smell. OECs act as pathway cells that enable nerve fibres in the olfactory system to be continually renewed. In the first of two operations, surgeons removed one of the patient's olfactory bulbs and grew the cells in culture. Two weeks later they transplanted the OECs into the spinal cord, which had been cut through in the knife attack apart from a thin strip of scar tissue on the right. They had just a drop of material to work with - about 500,000 cells. About 100 micro-injections of OECs were made above and below the injury. BBC © 2014
Keyword: Regeneration; Stem Cells
Link ID: 20229 - Posted: 10.22.2014
BY Tina Hesman Saey SAN DIEGO — A Golden retriever that inherited a genetic defect that causes muscular dystrophy doesn't have the disease, giving scientists clues to new therapies for treating muscle-wasting diseases. The dog, Ringo, was bred to have a mutation that causes Duchenne muscular dystrophy in both animals and people. His weak littermates that inherited the same mutation could barely suckle at birth. But Ringo was healthy, with muscles that function normally. One of Ringo's sons also has the mutation but doesn't have the disease, said geneticist Natassia Vieira of Boston Children's Hospital and Harvard University October 19 at the annual meeting of the American Society of Human Genetics. The dogs without the disease had a second genetic variant that caused their muscles to make more of a protein called Jagged 1, Vieira and her colleagues discovered. That protein allows muscles to repair themselves. Making more of Jagged 1 appears to compensate for the wasting effect of the muscular dystrophy mutation, although the researchers don't yet know the exact mechanism. The finding suggests that researchers may one day be able to devise treatments for people with muscular dystrophies by boosting production of Jagged 1 or other muscle repair proteins. N. M. Vieira. The muscular dystrophies: Revealing the genetic and phenotypic variability. American Society of Human Genetics Annual Meeting, San Diego, October 19, 2014. © Society for Science & the Public 2000 - 2014
Keyword: Muscles; Movement Disorders
Link ID: 20226 - Posted: 10.22.2014
by Flora Graham This glowing blue web of neurons is usually what researchers examine when searching for a cure for Parkinson's. But a new study, part-funded by Parkinson's UK, hones in on the tiny yellow dots. These are the connections between brain cells known as synapses, has discovered a killer that targets these links, potentially paving the way for new treatments. Soledad Galli at University College London and her colleagues have found that the death of synapses in mice may be due to malfunctioning proteins called Wnt proteins. "If we confirm that Wnt is involved in the early stages of Parkinson's, this throws up exciting possibilities, not just for new treatment targets, but also for new ways to identify people with Parkinson's early on in their condition," says Galli. Most patients currently depend on the drug levodopa, which is over 50 years old and can have severe side-effects, in addition to becoming less effective over time. Moreover, it only masks the symptoms: there is no cure for Parkinson's and no way to stop its progression. Journal reference: Nature Communications, DOI: 10.1038/ncomms5992 © Copyright Reed Business Information Ltd
Keyword: Parkinsons; Apoptosis
Link ID: 20214 - Posted: 10.18.2014
|By Amy Yee Pouring a bucket of ice water over one's head may seem like a distant summer memory. But although the "ice bucket challenge" craze has died down, public awareness of amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, has never been stronger. The viral video campaign raised $115 million from more than 3 million donors for the ALS Association. In one month, from July 29 to August 29, donors raised $100.9 million, compared with $2.8 million during the same period the previous year. In early October, the ALS Association began spending that money. It approved $21.7 million of funding for six programs and initiatives by groups that include the academic-industry partnership ALS Accelerated Therapeutics, the New York Genome Center, three California labs that form the Neuro Collaborative, and Project MinE, which will map the genomes of 15,000 people with ALS (about 10 percent of ALS patients have a family member with the disease). The grants focus on developing gene therapies for common ALS genes and exploring approaches to counter two major contributors to the disease, the inflammation of nervous tissue and misfolded proteins in brain cells that control movement. These efforts may not only someday lead to new treatments, but may also point to the cause of ALS. At the level of basic research, scientists do not have a dominant theory from which to work, notes Tom Jessell, a neuroscientist and co-director of Columbia University's new Zuckerman Mind Brain Behavior Institute. Jessell is also the chair of the research advisory board of Project ALS, a nonprofit that identifies and funds ALS research. © 2014 Scientific American
Keyword: ALS-Lou Gehrig's Disease
Link ID: 20213 - Posted: 10.18.2014
By Carl T. Hall Even Clayton Kershaw, the Los Angeles Dodgers' pitching ace, makes mistakes now and then. And although very few of his mistakes seemed to do Giants hitters much good this season, a team of San Francisco scientists found a way to take full advantage. A new study by UCSF researchers revealed a tendency of the brain's motion-control system to run off track in a predictable way when we try to perform the same practiced movement over and over. The scientists found the phenomenon first in macaque monkeys, then documented exactly the same thing in Kershaw's game video. Although he struggled in a playoff appearance last week, the left-hander's pitching performance during the regular season was among the best on record. It included a minuscule 1.77 earned run average, a nearly flawless no-hitter in June, 239 strikeouts and only 31 walks. He led the major leagues with 10.85 strikeouts per nine innings pitched. In what turned out to be an early warm-up to the playoffs, UCSF scientists Kris Chaisanguanthum, Helen Shen and Philip Sabes delved into the motor-control system of the primate brain. Their study, published in the Journal of Neuroscience, could help design better prosthetic limbs — or make robots that move less like robots and more like Kershaw. Unlike most machines, our brains seem to never stop trying to adapt to new information, making subtle adjustments each time we repeat a particular movement no matter how practiced. This trial-by-trial form of learning has obvious advantages in a fast-changing world, but also seems prone to drift away from spot-on accuracy as those small adjustments go too far.
Keyword: Learning & Memory
Link ID: 20193 - Posted: 10.11.2014
by Andy Coghlan Ten years after the death of everyone's favourite Superman, Christopher Reeve, his son Matthew Reeve is pushing ahead with a spine-tingling clinical trial You're planning a large study of a paralysis treatment that has already helped four young men. What will it entail? This study will include 36 people with spinal cord injuries who will be treated with epidural stimulation – a technique in which a device is used to apply electrical current to the spinal cord. If we see the same results as we did in the first four, this therapy could have a profound impact on thousands of people living with paralysis. It has the potential to become as commonplace as the pacemaker is for cardiac patients. How well has the treatment worked for the four men who have already received it? Prior to epidural stimulation, they had all suffered chronic injuries caused by completely severed spinal cords. All four have seen dramatic improvements, including the ability to voluntarily move their toes, feet, ankles and legs, and even stand at times, when the device is on. One unexpected bonus has been the return of autonomic function, such as bladder and bowel control and sexual function. From a quality-of-life point of view, this is the biggest improvement. Also unexpectedly, these autonomic functions continue in all four men even when the device is switched off, although they still need it to stand, move their legs and do exercises. © Copyright Reed Business Information Ltd.
Keyword: Movement Disorders; Regeneration
Link ID: 20190 - Posted: 10.11.2014
Posted by Rachel Dolhun, MD, The ability to quit smoking, especially "cold turkey" or on the first attempt, has been heralded as a marker of strong willpower and determination. But could the ease with which one eschews cigarettes also serve as an early sign of Parkinson's disease (PD)? This is the conclusion drawn by Beate Ritz, MD, PhD, and colleagues from the University of California, Los Angeles in a recent study published in Neurology. Researchers compared lifelong tobacco use, use of nicotine substitutes, and individual's rating of their difficulty in trying to quit tobacco among 1,808 Danish people with PD and 1,876 control volunteers. They found that those with PD were less inclined to ever pick up the smoking habit, but, even if they did, they were less likely to need nicotine replacement therapies and able to more effortlessly stop smoking cigarettes. Therefore, ease of quitting smoking may be a sign of early PD. This joins a short list of other symptoms — smell loss, constipation and REM sleep behavior disorder — that usually predate diagnosis and are strongly associated with PD. Physicians rely heavily on such information to help confirm the diagnosis of Parkinson's, given that biomarkers, objective measurements of disease, are currently lacking. Research led by The Michael J. Fox Foundation is ongoing to identify biological markers of PD, which could help diagnose and treat people earlier. In the meantime, doctors must look for symptoms and behaviors to help identify Parkinson's. Researchers have long known that tobacco use was linked to a lower risk of PD. An ongoing Foundation-funded study is investigating whether nicotine might guard against or slow the progression of PD.
Keyword: Parkinsons; Drug Abuse
Link ID: 20189 - Posted: 10.11.2014
By Elizabeth Pennisi Four years ago, Igor Spetic lost his right arm in an industrial accident. Doctors outfitted him with a prosthetic arm that restored some function, but they couldn't restore his sense of touch. Without it, simple tasks like picking up a glass or shaking hands became hit-or-miss propositions. The lack of touch also robs Spetic of basic pleasures. "I would love to feel my wife's hand," he says. In time, he may regain that pleasure: Two independent research teams have now equipped artificial hands with sensors that send signals to the wearer's nerves to recreate this missing sense. The sensing technologies work only in the lab, but they have proved durable, and amputees who have tried them, including Spetic, say that they are effective. One technology advances the range of touch sensations available, while the other promises to enable touch through a better way to attach the prosthesis. "All of these results are very positive," says Mandayam Srinivasan, a neuroengineer at the Massachusetts Institute of Technology in Cambridge, who was not involved in either project. "Each of them fills a piece of the puzzle in terms of [prosthesis] development." Almost 40 years ago, researchers tried to provide sensory feedback by adding pressure sensors to prostheses that relayed the sensation through electrodes attached to nerves. But for the most part, they just made it seem like the hand was tingling. And durability has been an issue in such efforts, too. In February, Silvestro Micera, a neuroengineer at the Sant'Anna School of Advanced Studies in Pisa, Italy, and the Swiss Federal Institute of Technology in Lausanne and his team showed that it was possible for sensor-equipped prosthetic arms to gently or powerfully grab objects and even to distinguish a round from a square object. But the study lasted just 4 weeks, in part because of the delicate interface with the body. © 2014 American Association for the Advancement of Science.
Keyword: Pain & Touch; Robotics
Link ID: 20187 - Posted: 10.09.2014
by Colin Barras LOCKED in but not shut out: for the first time people who have lost the ability to move or talk because of a stroke may be able to communicate with their loved ones using a brain-computer interface. Brain injuries can leave people aware but almost completely paralysed, a condition called locked-in syndrome. Brain-computer interfaces (BCIs) can help some people communicate by passing signals from electrodes attuned to their brain activity as they watch a screen displaying letters. Subtle changes in neural activity let researchers know when a person wishes to select a particular on-screen item, allowing them to spell out messages by thought alone. Until now, BCIs have only been tested on healthy volunteers and people with amyotrophic lateral sclerosis, a neurodegenerative disease that leads to muscle wasting. But no one had tested whether the technology could help people locked in after a brain stem stroke. Now Eric Sellers and his colleagues at East Tennessee State University in Johnson City have tested the technique on a 68-year-old man. After more than a year of training he learned to communicate reliably via the BCI. He took the opportunity to thank his wife for her hard work, and to give his thoughts on gift purchases for his children (Science Translational Medicine, DOI: 10.1126/scitranslmed.3007801). © Copyright Reed Business Information Ltd.
Keyword: Stroke; Robotics
Link ID: 20185 - Posted: 10.09.2014
|By Tara Haelle The first step to treating or preventing a disease is often finding out what drives it. In the case of neurodegenerative disorders, the discovery two decades ago of what drives them changed the field: all of them—including Alzheimer's, Parkinson's, Huntington's and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)—involve the accumulation of misfolded proteins in brain cells. Typically when a protein misfolds, the cell destroys it, but as a person ages, this quality-control mechanism starts to fail and the rogue proteins build up. In Huntington's, for example, huntingtin protein—used for many cell functions—misfolds and accumulates. Symptoms such as muscular difficulties, irritability, declining memory, poor impulse control and cognitive deterioration accompany the buildup. Mounting evidence suggests that not only does the accumulation of misfolded proteins mark neurodegenerative disease but that the spread of the proteins from one cell to another causes the disease to progress. Researchers have seen misfolded proteins travel between cells in Alzheimer's and Parkinson's. A series of experiments reported in Nature Neuroscience in August suggests the same is true in Huntington's. In their tests, researchers in Switzerland showed that mutated huntingtin protein in diseased brain tissue could invade healthy brain tissue when the two were placed together. And when the team injected the mutated protein into a live mouse's brain, it spread through the neurons within a month—similar to the way prions spread, says Francesco Paolo Di Giorgio of the Novartis Institutes for BioMedical Research in Basel, who led the research. Prions are misfolded proteins that travel through the body and confer their disease-causing characteristics onto other proteins, as seen in mad cow disease. But it is not known if misfolded proteins involved in Huntington's convert other proteins as true prions do, according to Di Giorgio. © 2014 Scientific American
Keyword: Huntingtons
Link ID: 20181 - Posted: 10.08.2014
|By Tori Rodriguez Imagining your tennis serve or mentally running through an upcoming speech might help you perform better, studies have shown, but the reasons why have been unclear. A common theory is that mental imagery activates some of the same neural pathways involved in the actual experience, and a recent study in Psychological Science lends support to that idea. Scientists at the University of Oslo conducted five experiments investigating whether eye pupils adjust to imagined light as they do to real light, in an attempt to see whether mental imagery can trigger automatic neural processes such as pupil dilation. Using infrared eye-tracking technology, they measured the diameter of participants' pupils as they viewed shapes of varying brightness and as they imagined the shapes they viewed or visualized a sunny sky or a dark room. In response to imagined light, pupils constricted 87 percent as much as they did during actual viewing, on average; in response to imagined darkness, pupils dilated to 56 percent of their size during real perception. Two other experiments ruled out the possibility that participants were able to adjust their pupil size at will or that pupils were changing in response to mental effort, which can cause dilation. The finding helps to explain why imagined rehearsals can improve your game. The mental picture activates and strengthens the very neural circuits—even subconscious ones that control automated processes like pupil dilation—that you will need to recruit when it is time to perform. © 2014 Scientific American
Keyword: Learning & Memory
Link ID: 20176 - Posted: 10.08.2014
By Julie Rehmeyer Eight years ago, collapsed on a neurologist's examining table, I asked a naive question that turned out to be at the center of a long-running controversy: "So what is chronic fatigue syndrome?" I had just been diagnosed with the illness, which for six years had been gradually overtaking me. A week earlier, I had woken up barely able to walk. Fatigue hardly described what I felt. Paralysis was more like it. My legs seemed to have been amputated and replaced with tubes of liquid concrete, and just shifting them on the table made me grunt like an Olympic weightlifter. My bones hurt; my brain felt like a swollen mass. Speaking required tracking down and spearing each word individually as it scampered away from me. I felt as capable of writing an article about science — my job — as of killing a rhino with my teeth. "We don't understand it very well," my neurologist said, his face blank. He could recommend no tests, no treatments, no other doctors. I came to understand that, for him, the term chronic fatigue syndrome meant "I can't help you." My neurologist's understanding of the illness mirrored that of many doctors, who believe two things about CFS: that it's probably psychosomatic and that there's nothing doctors can do for it. One survey found that nearly half of doctors thought that CFS was or might be psychosomatic, and 58 percent said there wasn't enough information available to help them diagnose it. An examination of medical textbooks found that CFS was underrepresented, even compared with less-prevalent illnesses.
Keyword: Movement Disorders; Depression
Link ID: 20175 - Posted: 10.08.2014
By Gretchen Reynolds Encourage young boys and girls to run, jump, squeal, hop and chase after each other or after erratically kicked balls, and you substantially improve their ability to think, according to the most ambitious study ever conducted of physical activity and cognitive performance in children. The results underscore, yet again, the importance of physical activity for children's brain health and development, especially in terms of the particular thinking skills that most affect academic performance. The news that children think better if they move is hardly new. Recent studies have shown that children's scores on math and reading tests rise if they go for a walk beforehand, even if the children are overweight and unfit. Other studies have found correlations between children's aerobic fitness and their brain structure, with areas of the brain devoted to thinking and learning being generally larger among youngsters who are more fit. But these studies were short-term or associational, meaning that they could not tease out whether fitness had actually changed the children's' brains or if children with well-developed brains just liked exercise. So for the new study, which was published in September in Pediatrics, researchers at the University of Illinois at Urbana-Champaign approached school administrators at public elementary schools in the surrounding communities and asked if they could recruit the school's 8- and 9-year-old students for an after-school exercise program. This group was of particular interest to the researchers because previous studies had determined that at that age, children typically experience a leap in their brain's so-called executive functioning, which is the ability to impose order on your thinking. Executive functions help to control mental multitasking, maintain concentration, and inhibit inappropriate responses to mental stimuli. © 2014 The New York Times Company
Aaron E. Carroll For a drug to be approved by the Food and Drug Administration, it must prove itself better than a placebo, or fake drug. This is because of the "placebo effect," in which patients often improve just because they think they are being treated with something. If we can't compare a new drug with a placebo, we can't be sure that the benefit seen from it is anything more than wishful thinking. But when it comes to medical devices and surgery, the requirements aren't the same. Placebos aren't required. That is probably a mistake. At the turn of this century, arthroscopic surgery for osteoarthritis of the knee was common. Basically, surgeons would clean out the knee using arthroscopic devices. Another common procedure was lavage, in which a needle would inject saline into the knee to irrigate it. The thought was that these procedures would remove fragments of cartilage and calcium phosphate crystals that were causing inflammation. A number of studies had shown that people who had these procedures improved more than people who did not. However, a growing number of people were concerned that this was really no more than a placebo effect. And in 2002, a study was published that proved it. A total of 180 patients who had osteoarthritis of the knee were randomly assigned (with their consent) to one of three groups. The first had a standard arthroscopic procedure, and the second had lavage. The third, however, had sham surgery. They had an incision, and a procedure was faked so that they didn't know that they actually had nothing done. Then the incision was closed. The results were stunning. Those who had the actual procedures did no better than those who had the sham surgery. They all improved the same amount. The results were all in people's heads. © 2014 The New York Times Company
Keyword: Pain & Touch
Link ID: 20167 - Posted: 10.07.2014
By Lisa Sanders, M.D. On Thursday, we challenged Well readers to solve the mystery of a 62-year-old man with severe neck pain that spread down his arm, a facial droop, and numbness on his torso. Nearly 200 of you wrote in, and 20 of you correctly diagnosed the patient. The correct diagnosis is… Lyme disease. And more precisely, the early disseminated form of Lyme disease with neurological involvement The first person with the correct answer was Dr. Arielle Hay, a pediatric rheumatologist in Miami, who nailed it just half an hour after the case was posted. Dr. Hay said that the biggest clue was the UConn letterhead. When combined with the odd neurological symptoms, this reminder of where the case took place brought Lyme disease to mind. Lyme disease is one of those diseases that hardly needs an explanation. It was first described in 1977, in a case series of 51 children and parents who had mysterious episodes of joint pain and swelling. The children were initially diagnosed with juvenile rheumatoid arthritis, but the clustering of cases eventually led the investigators, Dr. Allen Steere and Dr. Stephen Malawista, to consider an infectious disease. The illness was named after the Connecticut town where most of the initial cases were located. The disease is caused by a spirochete, a spiral shaped bacterium carried by the Ixodes tick, and usually presents first with a distinctive, expanding red rash (called erythema migrans) that appears at the site of the bite in the early, localized stage of the disease. It is thought that the rash appears in up to 80 percent of Lyme infections. © 2014 The New York Times Company
Keyword: Pain & Touch; Movement Disorders
Link ID: 20166 - Posted: 10.07.2014
By Kevin Hartnett You may have seen that deliberately annoying "View of the World from Ninth Avenue" map featured on the cover of the New Yorker a while back. It shows the distorted way geography appears to a Manhattanite: 9th and 10th avenues are the center of the world, New Jersey appears, barely, and everywhere else is just a blip if it registers at all. As it turns out, a similar kind of map exists for the human body — with at least some basis in neuroscience. In August I wrote a story for Ideas on the rise of face transplants and spoke to Michael Sims, author of the book, "Adam's Navel: A Natural and Cultural History of the Human Form." During our conversation Sims mentioned an odd diagram published in 1951 by a neurosurgeon named Wilder Penfield. The diagram is known as "Homunculus" (a name taken from a weird and longstanding art form that depicts small human beings); it shows the human body scaled according to the amount of brain tissue dedicated to each part, and arranged according to the locations in the brain that control them. In the diagram, the eyes, lips, nose, and tongue appear grotesquely large, indicating that we devote an outsized amount of brain tissue to operating and receiving sensation from these parts of the body. (Sims's point was that we devote a lot of processing power to the face, and for that reason find it biologically disorienting that faces could be changeable.) The hand is quite large, too, while the toes, legs, trunks, shoulders, and arms are tiny, the equivalents of Kansas City and Russia on the New Yorker map. "Homunculus" seems like the kind of thing that would have long since been superseded by modern brain science, but it actually continues to have a surprising amount of authority, and often appears in neuroscience textbooks.
Keyword: Pain & Touch
Link ID: 20158 - Posted: 10.04.2014
James Hamblin Mental exercises to build (or rebuild) attention span have shown promise recently as adjuncts or alternatives to amphetamines in addressing symptoms common to Attention Deficit Hyperactivity Disorder (ADHD). Building cognitive control, to be better able to focus on just one thing, or single-task, might involve regular practice with a specialized video game that reinforces "top-down" cognitive modulation, as was the case in a popular paper in Nature last year. Cool but still notional. More insipid but also more clearly critical to addressing what's being called the ADHD epidemic is plain old physical activity. This morning the medical journal Pediatrics published research that found kids who took part in a regular physical activity program showed important enhancement of cognitive performance and brain function. The findings, according to University of Illinois professor Charles Hillman and colleagues, "demonstrate a causal effect of a physical program on executive control, and provide support for physical activity for improving childhood cognition and brain health." If it seems odd that this is something that still needs support, that's because it is odd, yes. Physical activity is clearly a high, high-yield investment for all kids, but especially those attentive or hyperactive. This brand of research is still published and written about as though it were a novel finding, in part because exercise programs for kids remain underfunded and underprioritized in many school curricula, even though exercise is clearly integral to maximizing the utility of time spent in class. The improvements in this case came in executive control, which consists of inhibition (resisting distraction, maintaining focus), working memory, and cognitive flexibility (switching between tasks). The images above show the brain activity in the group of kids who did the program as opposed to the group that didn't. It's the kind of difference that's so dramatic it's a little unsettling. The study only lasted nine months, but when you're only seven years old, nine months is a long time to be sitting in class with a blue head. © 2014 by The Atlantic Monthly Group.
Keyword: ADHD
Link ID: 20152 - Posted: 10.02.2014
By CATHERINE SAINT LOUIS Driven by a handful of reports of poliolike symptoms in children, federal health officials have asked the nation's physicians to report cases of children with limb weakness or paralysis along with specific spinal-cord abnormalities on a magnetic resonance imaging test. As a respiratory illness known as enterovirus 68 is sickening thousands of children from coast to coast, officials are trying to figure out if the weakness could be linked to the virus. The emergence of several cases of limb weakness among children in Colorado put doctors on alert in recent months. The Centers for Disease Control and Prevention issued an advisory on Friday, and this week, other cases of unexplained muscle weakness or paralysis came to light in Michigan, Missouri and Massachusetts. The C.D.C. is investigating the cases of 10 children hospitalized at Children's Hospital Colorado with unexplained arm or leg weakness since Aug. 9. Some of the children, who range in age from 1 to 18, also developed symptoms like facial drooping, double vision, or difficulty swallowing or talking. Four of them tested positive for enterovirus 68, also known as enterovirus D68, which has recently caused severe respiratory illness in children in 41 states and the District of Columbia. One tested positive for rhinovirus, which can cause the common cold. Two tested negative. Two patients' specimens are still being processed; another was never tested. It is unclear whether the muscle weakness is connected to the viral outbreak. "It's one possibility we are looking at, but certainly not the only possibility," said Mark Pallansch, director of the C.D.C.'s division of viral diseases. © 2014 The New York Times Company
Keyword: Movement Disorders
Link ID: 20150 - Posted: 10.02.2014
By Gretchen Reynolds Exercise may help to safeguard the mind against depression through previously unknown effects on working muscles, according to a new study involving mice. The findings may have broad implications for anyone whose stress levels threaten to become emotionally overwhelming. Mental health experts have long been aware that even mild, repeated stress can contribute to the development of depression and other mood disorders in animals and people. Scientists have also known that exercise seems to cushion against depression. Working out somehow makes people and animals emotionally resilient, studies have shown. But precisely how exercise, a physical activity, can lessen someone's risk for depression, a mood state, has been mysterious. So for the new study, which was published last week in Cell, researchers at the Karolinska Institute in Stockholm delved into the brains and behavior of mice in an intricate and novel fashion. Mouse emotions are, of course, opaque to us. We can't ask mice if they are feeling cheerful or full of woe. Instead, researchers have delineated certain behaviors that indicate depression in mice. If animals lose weight, stop seeking out a sugar solution when it's available — because, presumably, they no longer experience normal pleasures — or give up trying to escape from a cold-water maze and just freeze in place, they are categorized as depressed. And in the new experiment, after five weeks of frequent but intermittent, low-level stress, such as being restrained or lightly shocked, mice displayed exactly those behaviors. They became depressed. The scientists could then have tested whether exercise blunts the risk of developing depression after stress by having mice run first. But, frankly, from earlier research, they knew it would. They wanted to parse how. So they bred pre-exercised mice. © 2014 The New York Times Company
Keyword: Depression
Link ID: 20145 - Posted: 10.01.2014


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First Look at Dane DeHaan as James Dean Opposite Robert Pattinson in Anton Corbijn's LIFE
by Adam Chitwood Posted 288 days ago
The first image from director Anton Corbijn's (The American) upcoming drama Life has landed online. The film chronicles the friendship between Magnum photographer Dennis Stock and actor James Dean as the two took a journey across the U.S. for a 1955 Life Magazine assignment. Dane DeHaan leads the film as Dean, while Robert Pattison takes on the role of Stock. It's tough to judge how much DeHaan embodies the role of Dean based on this one slightly obstructed image, but the pieces are all in place for a fascinating drama that provides an interesting point of view on Dean's life.
Hit the jump to take a look at the image and to read what Corbijn had to say about the casting. The film also stars Ben Kingsley. Life is currently in the midst of production in Canada but a release date has yet to be set.


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Please join us…
Sunday mornings
at 9:15 for Bible classes for
all ages
and Wednesday evenings at 6:30!
Welcome! We are glad you are interested in Broadway's Children Ministry. We
try to focus on what is most important: helping equip your family as you train your children in a
life-long relationship with God.
We pray we can bless your family with helpful suggestions for strengthening family study time, prayer life, Bible verse memorization, and conversations about God in your day-to-day life while encouraging you in the incredibly precious and important task God has given you of raising His little children.
We are blessed to be a part of your family's journey of faith.
Memory Verse for August
Every good and perfect gift is from above, coming down from the Father of the heavenly lights, who does not change like shifting shadows.
To encourage our scripture memorization, we give the Seeds Family Worship CDs to Broadway families and use them in our childrens' Bible classes, learning a new scripture each month! If you don't have a copy, just ask! You can learn more about the songs at:
Seeds Family Worship The lyrics are God's own Word, straight from the NIV. It's a great way to sing and make a joyful noise unto the Lord, while planting His Word forever in our hearts and minds! Listen online! seedsfamilyworship.net
SUMMER! We are enjoying a fantastic summer of growing closer as families, and as a church family. You'll notice we have scheduled various Family Nights so more of our Broadway families can participate through the summer, regardless of work schedules or travel plans, and have more opportunities to invite friends!
Family Game Night Aug 22
Trunk n Treat October 31 6-8pm
Join us and our Broadway neighbors for a fun, safe evening. We will have inflatable bouncers, a barrel train, food and LOTS of candy.
"Listen, O Israel! The Lord is our God, the Lord alone. And you must love the Lord your God with all your heart, all your soul, and all your strength. And you must commit yourselves wholeheartedly to these commands that I am giving you today. Repeat them again and again to your children. Talk about them when you are at home and when you are on the road, when you are going to bed and when you are getting up. Tie them to your hands and wear them on your forehead as reminders. Write them on the doorposts of your house and on your gates." Deuteronomy 6:4-9


text: Ordered for my daughter. She loves to bake pies, cakes, cookies. Today baked for tea terrific pastry that looks great thanks to the beautiful forms with labels. Reminiscent of childhood. The forms are easy to clean, durable and extremely easy to use. If you're at home doing cookies or biscuits - you ... Read more


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Factors predicting consumers' knowledge of spirulina health benefits
Kamenidou, Irene and Priporas, Constantinos-Vasilios (2010) Factors predicting consumers' knowledge of spirulina health benefits. Journal of Food, Agriculture & Environment, 8 (1). pp. 16-20. ISSN 1459-0255
Full text is not in this repository.
Official URL: http://www.isfae.org/scientficjournal/2010/issue1....
Due to its numerous health benefits for humans spirulina is gaining interest as a nutraceutical, deriving in this way in its commercial demand worldwide. This paper reports the results of a study conducted within the above context. Researchers investigated awareness and factors predicting consumers subjective knowledge level of spirulina and its health benefit attributes. This research also examined source of knowledge, and willingness to be informed. Data were collected through a series of aided self administrated questionnaires employing the mall intercept technique, with 966 participants in Athens, Greece. The findings demonstrated that more than the half of the sample was not aware of the product, while moderate knowledge levels of the product's attributes and benefits exist. Factor analysis produced four factors, accounting for 75.4% of total variance. Implications for product awareness and increase of knowledge levels are discussed.
|Item Type:
|Keywords (uncontrolled):
|Nutraceuticals, spirulina, consumer knowledge, marketing, factors
|Research Areas:
|Middlesex University Schools and Centres > Business School > International Management and Innovation
Middlesex University Schools and Centres > Business School > International Management and Innovation > Strategic Marketing, Consumer Behaviour and Branding/Identity group
|ID Code:
|Deposited On:
|01 Oct 2012 06:56
|Last Modified:
|21 Nov 2014 16:44
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The Cancer Knockers Fight Against Cancer by Cancer Knockers - over 1 year ago
"My Breast Cancer Team (Cancer Knockers) participates annually in the Susan G Komen Global Race for the Cure. This year's event was held on Saturday, May 11th in Washington, DC. We were really exc..." view full details


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If you need a high quality professional pressure washing service we are here to help.
Va Beach: 757.215.1967
Envirowash will gently and effectively clean and pressure wash your siding, roof, deck and more in a safe manner without the damaging effects of high pressure or harsh detergents. We guarantee it.
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We are one of the few commercial building pressure washing contractors in Virginia to be qualified to clean government and municipal buildings for the state.
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Paul Graziani is chief executive officer and co-founder of Analytical Graphics, Inc. (AGI), the producer of commercial off-the-shelf (COTS) analysis software for land, sea, air, space and cyberspace. For more than 20 years, he has championed the use of COTS in the national security and space industries, and, today, AGI's flagship product, STK, is used in more than 40,000 worldwide installations by aerospace, defense and intelligence professionals. Graziani started his career at General Electric Space Division in 1980, where he held a number of software and engineering roles.
When Graziani and two colleagues launched AGI in his living room in 1989, they put work practices in place that over the years have earned AGI local, state and national recognition for its innovative work environment. In 2004 and 2005, AGI was named the Best Small Company to Work for in America by the Great Place to Work Institute and the Society for Human Resource Management. In 2006, it took the top spot in the medium company category. AGI was also ranked as one of five top aerospace/ military work environments in North America by Aviation Week and Space Technology in 2009, 2010 and 2011, and by Leadership Excellence magazine as the No. 1 small- to mid-sized firm in North America for leadership development programs.
Graziani has been nominated for and received a number of entrepreneurial excellence awards at both local and national levels. AGI has also enjoyed strong growth and has been named to numerous prestigious lists, including the Military Training Technology magazine's Top 100, Space News Top 50, Inc. 500, Technology Fast 50, Technology Fast 500, Philly 100 and Softletter Top 100.
Graziani sits on the boards of directors of Passur Aerospace, the United States Geospatial Intelligence Foundation (USGIF) and Federation of Galaxy Explorers (FOGE). He is a member of the board of governors for the Civil Air Patrol (CAP). He formerly served on the Advisory Board for Penn State Great Valley and is an associate fellow of the American Institute of Aeronautics and Astronautics (AIAA). After fulfilling his board tenure, he was recently elected to the honorary position of life director of The Space Foundation. He earned a B.S. in biology from LaSalle College.
Scott Reynolds is the chief software architect and vice president of AGI. He is one of three founders of AGI, the leading producer of commercial analysis and visualization software for the national security and space communities. Reynolds is responsible for the architectural oversight of the STK software suite; providing leadership and management on design strategies; and focusing on the development and maintenance of 2-D and 3-D graphics within the product offerings. Reynolds' key role is the development of software architectures that provide a flexible platform for the STK product suite and custom AGI technology solutions.
Reynolds spent eight years at General Electric (Space Division), where he served as a senior software engineer. In this capacity, he developed state-of-the-art software for classified real-time satellite command and control systems. In January 1989, he left GE to start AGI. He and two other founders created STK, the company's flagship product, in the belief that the increasing use of computer graphics to translate large amounts of raw data into manageable and useful information would transform space systems analysis.
Along with fellow co-founder Graziani, Reynolds was named the regional winner in the technology category of Ernst & Young's 2005 Entrepreneur of the Year contest. Reynolds was named a regional finalist in the 1998, 2000, and 2002 competitions. Reynolds earned his bachelor's of science degree in computer and information science from the University of Florida. He resides with his wife and three children in West Chester, PA.
Joseph Sheehan, is president of Analytical Graphics, Inc. (AGI), the producer of commercial off-the-shelf (COTS) analysis software for land, sea, air, and space. AGI's flagship product, STK, is used in more than 40,000 worldwide installations by aerospace, defense and intelligence professionals. Most recently AGI was named one of fifteen "Top Small Workplaces 2009" by The Wall Street Journal and the non-profit organization Winning Workplaces.
Sheehan guides the company's operational and financial strategic planning and organizational development activities. He came to AGI in the spring of 2009 after serving as president of TruePosition, Inc., the leading provider of location determination and intelligence solutions for safety and national security markets worldwide.
Sheehan joined TruePosition in 1995 as its director of software development and over the next 12 years advanced to vice president of product development, chief technology officer, and ultimately its president and COO. Under his leadership, TruePosition grew from a startup company to a mature operating business with $260M+ annual sales. Prior to joining TruePosition, Sheehan served as director of software engineering at AirTouch Teletrac — a pioneer in automatic vehicle location technology — and held various software engineering positions at SAIC, a Fortune 500 scientific, engineering and technology applications company.
Sheehan is an inventor and co-inventor and holds more than 10 U.S. patents. He sits on the Board of Advisors for Illume Software, Inc. and is a member of the Philadelphia Chapter of the Young Presidents Organization. He holds a B.S. in computer science from Washington University in St. Louis.
Francesco Linsalata is AGI's chief operating officer (COO). Appointed to this position in June of 2001, Linsalata has the executive responsibility of AGI's daily operations, overseeing the sales, business development, marketing, engineering and product development departments. Prior to this, Linsalata was vice president of marketing from 1999 to 2001.
Linsalata joined AGI in 1991 as a software engineer. In that capacity, he focused on the development of sensor algorithms and supported custom development efforts. In November 1995, Linsalata started AGI's Business Partner Program. His primary responsibility was to identify strategic partners who could provide new, complementary business channels for the STK product line and champion the integration of their software solutions.
From October 1997 through March 1999, prior to his vice president of marketing role, Linsalata served as vice president of technical services. In this assignment, he was responsible for building the technical infrastructure necessary for AGI to interface with the continuously growing STK customer base. This included leading the technical support, business partners, system engineering, training, and video production departments.
Linsalata began his professional career in 1986 with Stanford Telecommunications, Inc. of Reston, VA, as part of the System Engineering Division's Advanced Programs team. Linsalata primarily focused on product development, leading the development of Satellite Graphics Analysis Tool (SGAT), the company's first commercial off-the-shelf software product.
Linsalata received his B.S. in electrical engineering and computer science from Johns Hopkins University in 1985.
William J. Broderick has served as AGI's chief financial officer (CFO) since July 1996. In this role, he has executive management responsibility for the finance, accounting, legal, human resources, government relations and administrative operations of AGI. In addition, working with the CEO, he is responsible for the overall strategic planning and direction of the company.
From 1990 to 1996, Broderick, a Certified Public Accountant, was the owner of a public accounting firm that provided management advisory, finance, accounting and tax services to clients in information technology, manufacturing and professional services industries. After joining AGI, Broderick sold his practice to a regional public accounting firm located in the suburban Philadelphia area.
From 1984 until 1989, Broderick was an accountant and manager for Niessen, Dunlap, & Pritchard, a regional public accounting firm located in the Philadelphia area. He worked in the firm's Management Advisory Services Group providing services to a broad base of clients in areas including accounting, auditing, financial reporting, finance, forecasting, tax, mergers and acquisitions, valuation, litigation support and expert testimony.
Broderick received his B.S. in business administration/accounting with a minor in economics from Bloomsburg University in 1984. He is a member of the American and Pennsylvania Institutes of Certified Public Accountants.
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From Library of Congress Subject Headings
- http://id.loc.gov/authorities/subjects/sh2008113010
- info:lc/authorities/sh2008113010
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Instance Of
- Trio sonatas (Flute, violin, continuo)
- Scores and parts
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Collection Membership(s)
- found: Work cat.: Triosonate in c-Moll für Oboe, Fagott und Basso continuo =, c2000
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Change Notes
- 2008-03-11: new
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4-Door Sedans and CoupesTalk0
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The following lists all available 4-door sedans and coupes in the series. The primary distinction of this class of vehicles is that they seat up to 4 passengers, and do not include station wagons.
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" The Jugular Jug MkII is a saloon in Grand Theft Auto: London 1969. Assuming the appearance of a...
Jug MkII
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Allen West
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A Chance to Meet Michelle Fields - Posted July 15, 2013
We could hardly contain ourselves when we got word that Next Generation.TV's Allen West and Michelle Fields would be the stars at an upcoming happy hour. Apparentl... [FishbowlDC]
Allen West Named Fox News Contributor - Posted May 17, 2013
Former Congressman Allen West (R-FL) has joined Fox News as a contributor, the channel announced. West was known for his outspoken views in Congress, views which often became fodder for cable news. He will appear across all FNC shows and platforms. "Repre... [TVNewser]
How To Make It All About Me: The Michelle Fields Edition - Posted March 20, 2013
CPAC has come and gone and all we have left are the memories. Interesting sights and sounds were everywhere. Just don't tell Michelle Fields, who found numerous ways to make it all about her. Fields, who maintains her own ... [FishbowlDC]
Decision Not to Release Bin Laden Photos Sparking Debate - Posted May 4, 2011
[caption id="attachment_20427" align="alignleft" width="300" caption="WH Press Secretary Jay Carney"][/caption] During a briefing today, White House Press Secretary Jay Carney repeated and reiterated the ... [AgencySpy]


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Susan Richards
Revolving Door (0)
Who's coming and who's going. Tell us about your job move! Receive the Revolving Door Newsletter with expert analysis by email twice a week.No Revolving Door results were found.
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Soho Press Co-Founder Laura Hruska Has Died - Posted January 12, 2010
Soho Press co-founder and EIC Laura Hruska passed away this weekend at 74-years-old. Hruska helped found the press in 1986, and it has now grown into a publisher that releases between 60 and 80 titles every year. During her long career, she supported ... [GalleyCat]


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.- Yesterday at noon, Pope John Paul II appeared at the window of his hospital room for the recitation of the Angelus, which he had hoped to preside at. He said a blessing for the faithful gathered in the courtyard of Gemelli hospital as well as in St. Peter's Square where four massive television screens transmitted the Marian prayer. Substitute of the Secretariat of State, Archbishop Leonardo Sandri, read a message from the Pope and led the Angelus, following which the Holy Father imparted his apostolic blessing.
"Today I address you from Agostino Gemelli Polyclinic," the Pope's message began, "where, for several days, I have been cared for with loving solicitude by doctors, nurses and health personnel, whom I thank with all my heart."
I hope that the expression of my thanks for your sincere affection, which I have felt so intensely during these days, reaches you dear brothers and sisters, and everyone around the world who has been close to me."
The Holy Father assured the faithful of his prayers for them "according to your intentions, as well as for the needs of the Church and the great causes of the world. Thus, even here in the hospital, in the midst of other sick people, to whom I send affectionate thoughts, I continue to serve the Church and all of humanity."
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Civic Health IndexService YearAnnual Conference and EventsCivic Data ChallengeThe Civic 50
Jane Madden
Edelman, Senior Vice President of CSR and Sustainability
July 20, 2010
Jane Madden leads Edelman's Chicago CSR & Sustainability practice. Jane is a sustainable development expert with 23 years experience in over 20 countries including, Afghanistan, China, Russia and Saudi Arabia. She brings a wealth of expertise in emerging markets, stakeholder engagement , NGO's and multilateral organizations. Before joining Edelman, Jane ran her own CSR consulting firm, Social Sustainability International where she advised multilateral agencies, NGO's and private sector clients on environmental, social and governance strategies, capacity building and partnerships. Her clients included Ben & Jerry's, Xerox, The Brookings Institution and The Inter–American Development Bank.
Since joining Edelman, Jane has developed a comprehensive CSR strategy for Humana, one of the country's largest Medicare providers and a top health insurer, that implements the triple bottom line of healthy people, healthy planet and healthy performance. She advises SC Johnson on building NGO partnerships in India and China and has provided counsel on ingredients disclosure ,executive positioning and sustainability. She is also developing a CSR strategy and signature philanthropy program for Motorola. BASF, Wrigley and Quaker are also among her clients. Jane also leads the Edelman partnership with the Global Reporting Initiative, the gold standard for sustainability reporting
Jane served for 12 years as World Bank official. Her portfolio comprised technology, education, gender and transitional economies. Jane launched the World Bank Global Development Learning Network Center in Kabul, Afghanistan. By engaging key stakeholders from the Afghan government, NGO's and the local community, she expanded local policy makers' access to global information and knowledge. Jane also served on the Bank's Community Outreach Committee and was a subject matter reviewer for the Development Marketplace competition. Jane has held positions at CARE, UNICEF and the European Union. She serves on the Board of Trustees of CHF International, an international humanitarian organization and is a Director at Citizen Effect, an innovative micro–philanthropy NGO and the Step Up Women's Network. Previously, she served as Director of the Sustainable Business Network of Washington and as President of the Washington Literacy Council where she also tutored adults for 10 years. Jane is a member of the Chicago Sustainable Business Alliance and the Women's Council on Energy and the Environment.
Jane earned a BA in French from Fordham University and an MA, with distinction, in International Affairs and Political Economy from American University's School of International Service.
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BRUNSWICK, Ga. The man who reported the slayings of seven in a Georgia mobile home faces charges of lying to police and tampering with evidence, and authorities said Sunday they haven't ruled him out as a suspect in the killings.
The killer was not among the dead found Saturday, or the two people critically injured, said Glynn County police Chief Matt Doering, who said police have not spoken to the two hospitalized.
Guy Heinze Jr., 22, was arrested late Saturday and also faces charges of illegal possession of prescription drugs and marijuana, said Doering.
"He was a family member who came home and discovered (the victims), at least that's what he told us," Doering said.
Asked whether Heinze was involved in the slayings, Doering said: "I'm not going to rule him out, but I'm not going to characterize him as a suspect."
Police have not released the names of victims, some in their teens, or said how they died. The home is on an old plantation, nestled among centuries-old, moss-draped oak trees in coastal southeast Georgia.
"We just simply don't have a lot to go on," Doering said. "I'm not going to tell people not to be cautious. Until we know exactly what happened and who did it, that's not going to change."
The chief said police know what happened, but not who committed the slayings or why, saying "it's not a scene that I would want anybody to see."
The Georgia Bureau of Investigation began autopsies Sunday.
Investigators spent a second day Sunday scouring for new evidence at the home, where an old boat sat in the front yard. Officers on all-terrain vehicles searched roadsides within two miles of the mobile home park for evidence, without success.
The 1,100-acre mobile home park is all that remains of a Crown grant made in 1763 to Henry Laurens, who later succeeded John Hancock as president of the Continental Congress in 1777.
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Very recently I purchased Tia the beautiful Tilda star dress from the lovely the princess and the frock.
This dress was designed to remember "Tilda" a shining star, and 20% of the profits of each dress is donated to Bliss charity when you buy one. So it's not just a pretty dress you see, it's memories and fundraising. Helping to support parents with premature babies.
All dresses from the princess and the frock are handmade and made to order. I waited ten days for this pretty parcel to be delivered, which I thought was a brilliant turn around. The quality of this dress is amazing, I love the buttons and the colours are so vibrant. It's just perfect, and Tia agrees. As soon as she saw it, she wanted to wear it.
Every time she wears it, we are stopped in the street to be asked about it. It truly is a beautiful dress, and we are proud to wear it to remember a star.
I haven't been asked to write this post, I purchased the dress myself and loved it so much, that I wanted to share it and it's story. Xx


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Changing body types - yay!
I'm one of the so-called 'slow losers' out there - so I take any small victory and run with it...
Has anyone else here noticed something about their body as they progress with JUDDD that may have otherwise remained hidden?
For example; I never realised that I'm actually an hourglass shape! :laugh:
I always thought I was boyish or athletic with not much of a waistline (I've got a lot of muscle tone and broadish shoulders) but it seems JUDDD has taken some extra from around the middle - leaving me with noticeable curves for the first time ever! Even at my smallest, I've always been straight up and down, so this excites me!
I've also kept the, uh, chest benefits from my last weight gain (uh, can anyone say anxiety and birth control pills!) so it's probably magnified the whole hourglass thing!
Has anyone else had any similar discoveries?
i"m brand new to this WOE, so have not seen any changes, but want to say WHOO HOO to you. That's great!:jumpjoy::clap:
I hope the waist thing happens to me. I used to have a waistline, but now I'm almost the same measurement around my bra band, waist and abdomen.
It's great to notice the small milestones and celebrate them. It really is about more than just the number on the scale.
Absolutely - the scale is never as responsive (for me) as my clothes are. I believe the scale is some sort of psychological torture device. :annoyed:
I hope your waist behaves too!
That is SO cool! Especially when you consider losing inches around your waist should mean reducing stress on your heart and lungs (not to mention how much fun - and how attractive - belts can be!)
I've lost an extra 10# during maintenance, but I've noticed since losing these last 5# (down to 135 - 140#) that the layer of fat over my legs/hips/thighs/butt is much less.
Maybe it's due to the Callanetics I've been doing since the end of Jan., but I can see and feel that my legs/other areas are firm and toned. Sometimes I find myself pushing on my legs because I can't believe how they have changed from jiggly fat layer to a feel of taut muscle (not big, bulky muscle, just tight, slim muscle).
I'm also feeling this same thing on my abs, though the muscle there isn't developed enough yet to show through as a 6pack.
It's apparently true that losing weight on JUDDD takes away the fat but not the muscle. :)
Sophiethecat - I find myself doing the same! My thighs have never really been too big, but lately I catch myself feeling and noticing how toned and taut they feel - rather than that usual jiggle. Heh. It's nice. Callanetics is great for the toning - I am looking forward to getting back into it once I've hulled a little more of the fat off my arms and tummy!
I think I'm definitely more lean since starting JUDDD - though I did get down to a lower weight while low-carbing a few years back, I don't think I was even lean. I was that much maligned 'skinny fat' - with muscle bulk that was completely untoned!
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Home » News » Animals
Art the osprey begins long journey home to NH
Art, who has made the treacherous migration and return trip from South America seven times, was among three ospreys who departed from New Hampshire late in the fall. Two other transmitter-equipped juvenile ospreys, Jill and Chip from the Tilton area, are presumed to have perished. In 2011, the center lost another juvenile female, Saco, during migration.
Project leader and Squam Lakes Natural Science Center Executive Director Iain MacLeod, an internationally-recognized osprey researcher, is working with Dr. Rob Bierregaard, a Distinguished Visiting Research Professor at the Department of Biology at the University of North Carolina who has tracked nearly 40 ospreys using satellite technology.
Coincidentally, two of the ospreys that Dr. Bierregaard is tracking departed Venezuela on the same day, March 15, MacLeod said. He estimated that Art's return trip would take three weeks - less than the five-week migration south - as he may be eager to return to his nest and his mate in Bridgewater.
Art was "a little slow to get going" on his return trip, only logging about 80 miles on his first day flying north, and another 70 over the next couple days. But he appears to be picking up speed and has advanced another 150 miles since Monday, according to tracking data. The nearly 5,000-mile trip to Brazil took Art 35 days.
On Wednesday, MacLeod said this week's snowstorm should not have an impact on Art's trek home at all since the snow will likely be gone by the time Art makes it to New England in a few weeks. If not, the mature raptor will simply either stay further south for a while.
"He would slow down and find somewhere to fish," MacLeod said.
Ospreys dine solely on fish and, down south, Art had much to choose from. In a log entry with Art's tracking data, (www.nhnature.org/programs/project_ospreytrack/osprey_mapART.php), MacLeod described the region Art chose to inhabit for the winter.
"He has a couple of regular roost sites that he uses every night and then spends most of each day perched next to an area of water - always on the lookout for the next fish dinner. He has plenty of choices on the Rio Tocantins. I recently came across a paper on the fish species found in the Tocantins watershed. The researchers documented 343 species of fish - there are a total of 48 freshwater fish species in New Hampshire, so Art has a little more variety in his diet down there," he wrote.
Once Art does arrive, he is expected to return to his nest atop a utility pole in Bridgewater on the Pemigewasset River.
"They are very faithful to existing nests," said MacLeod.
Art has nested in the same spot since 2007. If another osprey has claimed the nest, Art will fight to get it back. Ever faithful, Art will reunite with the same female osprey he has mated with for several years. The female, who is tagged but not equipped with a GPS transmitter, also summers in South America. Courtship will begin with Art bringing the female a fish, to show he's a good provider, and an aerial display. MacLeod said the female lays the eggs - up to three eggs, typically - in May. Once laid, the incubation takes 35 days. The chicks are cared for through the summer, and will likely migrate in the fall.
Dr. Bierregaard, who has tracked and studies ospreys for four decades, this year tracked ospreys from Massachusetts, Delaware and New York. Five birds wearing satellite transmitters down in South America all appear ready to come home. According to Dr. Bierregaard's web site (http://www.bioweb.uncc.edu/bierregaard/migration1.htm) one osprey, named Snowy, is a 2-year-old who will be coming north for the first time.
MacLeod added that two birds tracked by his colleagues were out of contact - and out of cell tower range - for months. The scientists didn't know if they were still alive, but the good news this week was the birds are alive and on their way north, according to the latest data upload from the transmitters.
The Science Center has funding from PSNH again this year to tag four more New Hampshire ospreys and follow their migrations. MacLeod said this season the center will track four adults as the failure rate for juveniles on their maiden flight is so high. The transmitters run more than $4,000 apiece.
Schools that want to get involved in the new international osprey project should contact MacLeod at email@example.com.
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