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Two-lock box delivers cancer therapy
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Rice University researchers find new possibilities for benign, 'tunable' virus
HOUSTON – (May 6, 2014) – Rice University scientists have designed a tunable virus that works like a safe deposit box. It takes two keys to open it and release its therapeutic cargo.
The Rice lab of bioengineer Junghae Suh has developed an adeno-associated virus (AAV) that unlocks only in the presence of two selected proteases, enzymes that cut up other proteins for disposal. Because certain proteases are elevated at tumor sites, the viruses can be designed to target and destroy the cancer cells.
The work appears online this week in the American Chemical Society journal ACS Nano.
AAVs are fairly benign and have become the object of intense study as delivery vehicles for gene therapies. Researchers often try to target AAVs to cellular receptors that may be slightly overexpressed on diseased cells.
The Rice lab takes a different approach. "We were looking for other types of biomarkers beyond cellular receptors present at disease sites," Suh said. "In breast cancer, for example, it's known the tumor cells oversecrete extracellular proteases, but perhaps more important are the infiltrating immune cells that migrate into the tumor microenvironment and start dumping out a whole bunch of proteases as well.
"So that's what we're going after to do targeted delivery. Our basic idea is to create viruses that, in the locked configuration, can't do anything. They're inert," she said. When programmed AAVs encounter the right protease keys at sites of disease, "these viruses unlock, bind to the cells and deliver payloads that will either kill the cells for cancer therapy or deliver genes that can fix them for other disease applications."
Suh's lab genetically inserts peptides into the self-assembling AAVs to lock the capsids, the hard shells that protect genes contained within. The target proteases recognize the peptides "and chew off the locks," effectively unlocking the virus and allowing it to bind to the diseased cells.
"If we were just looking for one protease, it might be at the cancer site, but it could also be somewhere else in your body where you have inflammation. This could lead to undesirable side effects," she said. "By requiring two different proteases – let's say protease A and protease B – to open the locked virus, we may achieve higher delivery specificity since the chance of having both proteases elevated at a site becomes smaller."
In the future, molecular-imaging approaches will be used to detect both the identity and concentration of elevated proteases. "With that information, we would be able to pick a virus device from our panel of engineered variants that has the right properties to target that disease site. That's where we want to go," she said.
Suh said elevated proteases are found around many diseased tissues. She suggested these protease-activatable viruses may be useful for the treatment of not only cancers but also neurological diseases, such as stroke, Parkinson's and Alzheimer's diseases, and heart diseases, including myocardial infarction and congestive heart failure.
The ultimate vision of this technology is to design viruses that can carry out a combination of steps for targeting. "To increase the specificity of virus unlocking, you can imagine creating viruses that require many more keys to open," she said. "For example, you may need both proteases A and B as well as a cellular receptor to unlock the virus. The work reported here is a good first step toward this goal."
Co-authors are Rice alumni Justin Judd and Abhinav Tiwari; graduate students Michelle Ho, Eric Gomez and Christopher Dempsey; Oleg Igoshin, an associate professor of bioengineering; and Jonathan Silberg, an associate professor of biochemistry and cell biology, all at Rice; and Kim Van Vliet, an assistant research scientist, and Mavis Agbandje-McKenna, a professor, both at the University of Florida. Suh is an assistant professor of bioengineering.
The National Science Foundation, the National Institutes of Health, the American Heart Association and the Cancer Prevention and Research Institute of Texas supported the research.
Read the abstract at http://pubs.acs.org/doi/abs/10.1021/nn500550q
This news release can be found online at http://news.rice.edu/2014/05/05/two-lock-box-delivers-cancer-therapy/
Follow Rice News and Media Relations via Twitter @RiceUNews
Related Materials:
Laboratory for Nanotherapeutics Research (Suh): http://www.owlnet.rice.edu/~js8/
Rice Department of Bioengineering: http://bioe.rice.edu
Images for download:
An adeno-associated virus capsid (blue) modified by peptides (red) inserted to lock the virus is the result of research at Rice University into a new way to target cancerous and other diseased cells. The peptides are keyed to proteases overexpressed at the site of diseased tissues; they unlock the capsid and allow it to deliver its therapeutic cargo. (Credit: Junghae Suh/Rice University)
Modified adeno-associated viruses developed at Rice University are "locked" by peptides that respond to the presence of two proteases likely to be overexpressed at the site of cancerous or other diseased tissues. The proteases chew off the peptides, thereby unlocking the virus and allowing it to deliver its therapeutic cargo. (Credit: Junghae Suh/Rice University)
Junghae Suh (Credit: Jeff Fitlow/Rice University)
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,920 undergraduates and 2,567 graduate students, Rice's undergraduate student-to-faculty ratio is 6.3-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 2 for "best value" among private universities by Kiplinger's Personal Finance. To read "What they're saying about Rice," go here.News Source : Two-lock box delivers cancer therapy
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|I can't believe it, but I only got FOUR plants! LOL Mom got at least double, but many of hers were from the $1 (yes, ONE dollar!) area. She got a Ceanothus for one buck...incredible!
Ok, here's what I got! I already have plans where these plants will go in my yard, but I'd love to hear about any personal experience with these!
Sarcococca ruscifolia (sweet box), Campsis x tagliabuana 'Mme Galen' (trumpet creeper), Macfadyena unguis-cati (cat's claw), and Lantana 'Radiation'.
Mom also brought me a Lamium maculatum 'Beacon Silver' (spotted nettle), Stachys byzantina (lamb's ears), and the crowning glory of all plants I've ever received (since I've ALWAYS wanted one), a Cercis occidentalis (western redbud) seedling, right out of their yard!!
I gave Mom a couple things I bought last time, since they just aren't appropriate for my yard - Cryptomeria japonica 'Elegans' (plume cedar - beautiful, but eventually too big!) and Acer palmatum 'Bloodgood' (Japanese maple...only paid $6!). I also gave her a couple 'Autumn Beauty' sunflower seedlings I started.
I got everything I planned to buy, except a Centranthus ruber (Jupiter's beard), which I've always wanted. I didn't see it there, and I forgot to ask about it!
Follow-Up Postings:
|My gosh Brenda, you're getting me out of breath here. So glad that you had such a good time though, especially since you both enjoy the same things. "Lookie, lookie Brenda, another of your favorites"...."I see it, oh yes, I must have that one"...Brenda, I've really got to learn to draw cartoons, the imagination is going nutso and I'm enjoying every minute of it. Pat
|WOW! Talk about will power or was it that it is a little hot to plant??:) Well, right now you've got a break...All I know is the Radiation Lantana, that is really pretty. I got one of 7 different colors/varieties last summer, only a few came back through from the freeze. More might have but I thought they were dead, my excuse, I pulled them and planted climbers there and other roses. Then as the sprinklers sweep the yard were there was only dirt, up popped the lantana I had forgotten was there. So, maybe they all would have come back if I had left them.
I only have 3 plants. I have them at the fence line for colorful ground cover between the climbers and large roses.
You've got some work ahead of you to do then or did you do it yesterday:) I've been busy with grandkids and puppy sitting....
|You've got it, Pat - I always feel out of breath when Mom and I go plant shopping. Or when I'm showing her the plants in my yard. She's the one who got me started in gardening, and when I'm able to impress her just a little, I'm happy. :)
It was a little bit of willpower, Leslie, a little bit of knowing it's the wrong time to plant (NO natives for me this time! I'm waiting until FALL!! LOL)....but mostly, I'm broke. LOL DH and I have an anniversary trip planned to Reno on the 4th, so we're TRYING to save for gambling money. :D "Baby needs some new plants!" LOL
I'll definitely remember that about the Lantana! I used to have one, and it languished. Then a gopher dug all around the base of it....then the freezing temps this year. I had 2 blooms last year...and it never returned. I'm going to protect the heck out of this one, because I saw one at the post office one year here in Knights Landing, and it was gorgeous!
Plus, that beautiful orange goes SO well with all of my purplish/bluish/silver things!
|Wow!!! That one's really pretty, Leslie! I love all of the colors on it. Mine has red/orange/yellow, none of that hot pink.
My other Lantanas (montevidesis - trailing kind with lavender flowers) have put up with a lot of abuse from me over the years, but they keep returning. Interesting that the gophers don't mess with those.
|I think this one is Confetti, but not real sure. I had lavender but they either didn't come back or they were the ones I pulled the dead out and threw away. I've eyed the dark purple verbena, I want that really bad:)
No gopher would poke his head up long in my yard, LOL*
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Hank Azaria and his girlfriend, Katie Wright, are expecting their first child, a boy."They're quite ecstatic," the actor's rep tells People.Wright, a former actress studying to be a family therapist, is in her second trimester. The couple has been dating for two years. Azaria, who was previously married to Helen Hunt, can next be seen in May's Night at the Museum: Battle of the Smithsonian.
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Page 1 of 4
The IIT campus was buzzing with activity on the second day of its annual festival - Rendezvous.
It seems though, that IIT-D has downgraded its annual festival celebrations from last year when Anushka Sharma and Ranveer Singh were present along with the Jia band.
Running in its 50th year of existence, IIT-D hosted a number of sub-fests at the annual festival. These included Shubha Mudgal's performance at the Indian musical fest called Saaz and Mexican band Pate De Fua's performance at the International musical festival - Confluence. On display was also an Formula 1 car which was the centre of attraction for all curious bystanders. "Formula Student of Automotive Engineers (FSAE) is a course in IIT, and these guys can produce tech and machinery. They can even get together an F1 car," said Saurabh, a computer science student.
At RDX, a couples-only poolside dance was organised, however a lot of DU boys managed to get in and the IIT-ians, who were without female company, were given the cold shoulder by the girls. When a group of IIT-ians were asked why they were stranded without a girl in their own college, they replied, "The sex ratio here is skewed. We don't have a lot of girls." When prodded further they joked, "Probably girls don't like geeks and if they do probably we don't make for a very good-looking bunch."
Stay updated on the go with The Times of India's mobile apps. Click here to download it for your device.
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Some women are at greater risk for osteoporosis — the decrease of bone mass and density as a result of the depletion of bone calcium and protein — than others. Your doctor can help you determine your risk of developing osteoporosis by taking your personal and family medical history, and by performing a bone density test or bone mass measurement.
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Is Princess Celestia Evil? Prt 2Is Princess Celestia Evil? Part 2With a year to bide and even though she shows less then the previous season, Celestia is still weaving her webs of deceit and causing all kinds of mayhem for her hapless subjects!The Trollestia Hypothesis continues in this episode by episode recap of her dastardly behind the scenes machinations
The Return of Harmony-Why is Discord's Stony Form Left in a Public Garden?Discord, by far the most power and cunning villain Ponyville has ever faced although incased in stone following an ancient defeat it displayed like any other statue in a gardens public enough for a school field trip. Is Celestia so arrogant she had to show off her accomplishments in an easy accessible setting, implying that Discord is but one more of her palace's curios? Assuming she knew about the field trip (which seems likely since she's monarch and all) perhaps a quick update on the fact that a dark wizard was imprisoned in an easily breakable statue should have been made know
Analyzing: Scott Pilgrim vs The WorldAnalyzing and Improving: Scott Pilgrim Vs The WorldHaving never read the comic I cannot in good faith improve the 'story' of Scott Pilgrim, so this review will focus on the film specifically. The movie version takes its own liberties with the plot to make for a more cinematic experience, but in my opinion even these could have been refined. Scott Pilgrim is by no means a bad film, but in some ways it fell short of the high degrees of potential that its quality earned for itself. Below are my thoughts of how with a few slight considerations that potential might have been fully reached
WHAT WORKED1: Gorgeous ProductionScott Pilgrim is imaginatively and excitingly directed, edited and in many cases animated. The colors are primary and vibrant making it at all times even in mundane scenes look like a living comic book. Incorporating sound effects in words, captions, and video game related elements really lends a unique flavor to the proceedings and when they work they best they co


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On January 11, Peter Parker's prodigal clone, Kaine, starts his new life in Houston, Texas as a different kind of wallcrawling hero when SCARLET SPIDER #1 swings onto stands!
Before the new Scarlet Spider slings his first web, relive a special liveblog where writer Chris Yost, artist Ryan Stegman and editor Steve Wacker discussed this exciting new series!
well there goes my original idea of having a comic take place in my hometown that i was creating.


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Financing a college education is an investment in the future. Federal and state financial aid programs, as well as privately funded scholarships, are designed to provide additional financial resources for students who are serious about attending Yakima Valley Community College but do not have adequate resources to pay the full cost of attendance on their own.
The staff in the financial aid office is committed to helping you qualify for financial aid. However, financial aid is no substitute for good planning and preparation. Please read the informational pages of our website. Be sure to apply early. Financial aid processing, especially during peak periods, takes longer than you might expect. In particular, allow at least a month for loans to process before the start of a term.
If you are from out of town, have some start up money when you arrive for establishing your residence and arranging transportation. Start each term with some savings in hand so you can buy your books and be fully participating from the first day. Respond to any requests from the financial aid office in a timely manner and be sure to check the financial aid portal weekly.
If you need to drop off forms at the Yakima office outside our service hours, please leave forms at the Financial Aid Drop Box located on the front of the Financial Aid counter in Deccio Higher Education Center. Forms may also be mailed.
The portal will give you detailed information about missing application information, awards, loans, processed loans, appeal decisions and personalized other messages from the financial aid staff and much more!
The Financial Aid Portal may be unavailable at certain times due to system maintenance.
Financial Aid Portal
Access to data that is helpful to claim education credits when you file with your tax return. Official 1098-T forms for the 2013 tax year were mailed on 1/24/2014 by a servicer. If you need an official form and you have not received your 1098-T form by mid-February, contact the YVCC business office.
For further information on federal tax credits and other benefits please see IRS Publication 970, "Tax Benefits for Higher Education" on the IRS website at
http://www.irs.gov. The financial aid staff cannot provide advice on tax filing.
Tax Benefits
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Dinamica FinancieraNovember 19, 2010
Direct Marketing Associates Corp. and John M. Rainey, Jr.March 30, 2010
EdebitPayMay 25, 2011
Edge SolutionsAugust 5, 2008
Effect of Mortgage Broker Compensation Disclosures on Consumers and Competition: A Controlled ExperimentFebruary 27, 2004
Report presents the results of a study that examines the mortgage broker compensation disclosure proposed by HUD, as well as two alternative versions.
Effectiveness of "Opt-Out" Disclosures In Pre-Screened Credit Card Offers: A Report Submitted to the CommissionJuly 27, 2004
An FTC-commissioned consumer study which shows that opt-out notices that would be required by the proposed rule are significantly more effective than notices currently used to notify consumers of their opt-out right.
Electronic Processing, Inc.April 14, 2001
Electronic Signatures in Global and National Commerce WorkshopApril 3, 2001
Workshop gathering information to report to Congress on the benefits and burdens of a section of the Electronic Signatures in Global and National Commerce Act that authorizes use of an electronic record to send legally required information to consumers under certain circumstances.


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A speedway programme is an essential piece of kit for any fan who attends a meeting up and down the country.
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Mishawaka, IN (PRWEB) January 18, 2013
For many of the 974 cyclists who took part in the 4th Annual Bike Michiana for Hospice, it was a great day to get out on a bike and ride for a good cause. For others, it was a way to give back to an organization that had been there for a loved one at a time when care and support was most needed.
In 2011, Bruce Foster rode in his first Bike Michiana for Hospice, held in South Bend, IN. "I'd never really ridden before but I thought I could do the 40-mile ride," he said. That year, he rode in memory of his wife Sandy, a Center for Hospice Care patient who passed away on December 17th, 2010. "I wanted to take care of her myself," he said, "but towards the end, I needed help and they were there with the equipment, the supplies, everything. They told us what to expect through the process and made everything more comfortable for me and my daughters."
His mother helped his 2011 fundraising efforts by getting pledges and money. "She got about $1,500," he said. In April that year, she became a CHC patient after a heart attack and a diagnosis of congestive heart failure. "The caregivers were awesome. They had such a good relationship with her." After she passed away at Thanksgiving 2011, Bruce decided to take his commitment to Bike Michiana for Hospice to the next level. He bought a new bike and began training over the winter in anticipation of riding the 100-mile route. "I didn't know if I could do it, but decided to give it a shot."
He also decided to give raising $5,000 for the ride a shot as well. "I figured if my mom could raise $1,500 for my ride then I should give it a shot." His shot hit the mark and then some. With the help of family and friends around the country, Bruce raised $6,330.
Eric and Mark Streeter rode the longest route of the event – 125 miles – in memory of their father, Will Streeter, an avid cyclist who was a CHC patient. Will Streeter passed awa
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text: It's the question that often raises the most angst in expecting parents. No, it's not what to name the baby, or how to decorate the room, or whether to let the child sleep in the parents' bed. It's the hesitantly raised question that many consider years before they are even expecting children, "And what about the Santa thing?" Read More


text:
One person killed after double shooting in southwest Denver, gunman on the loose
Second gunshot victim is expected to survive
DENVER - One person died after a double shooting in southwest Denver late Tuesday night.
Denver police say two men were shot on South Alcott Street, near West Mississippi Avenue and South Zuni Street.
Denver police say both men were rushed to the hospital, where one man died. The second man is expected to survive.
Police are waiting for a suspect description, and expect to release more information later this morning.
The name of the victim has not been released by the Denver Office of the Medical Examiner.
Refresh this story for updates.


text: We're moving forward Pompano for Obama 2012 Posted by: Dvon Posted date: October 19, 2012 In: Video | comment : 0 Be Sociable, Share! Tweet ‹ Previous Next › About The Author Dvon Number of Entries : 546 Related posts PRAYER RALLY FOR PEACE Man Shot and Killed by St Louis Police Officers [Original] Chuvalo Boyd NNPA America's Daughters: Sex Trafficking Is A Global Issue Leave a Comment Click here to cancel reply. Name* Email* Website Submit Comment


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Matches your M-16.
Go to your weekly militia meetings and discuss the degeneration of society wearing the Hurley Women's One & Only YC Military Hat. The group hasn't decided what cause to fight for yet, but when you do you'll have the Sarah Connor look down with this cotton cap.
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Involvement:General (knows how to use it) - Ownership:1 day to 1 weekPros:
It works with my carrier here in Canada! The battery really does last a long time, I believe more than four hours the last time I checked. Good speed, enough to stream youtube.Cons:
My iPhones lose the connection quite often, and take a long time to connect. It seems to freeze up every day or two, requiring me to remove the battery to reboot it. I had to flash the firmware a number of times with different firmwares before it would work with my carrier. The stock firmware seems to default to AT and T as a profile, regardless of what other profiles I add.OtherThoughts:
This thing will work great for someone using it as a portable WiFi hotspot. I use it as my go-to router because I'm off-grid and want something with a tiny power consumption in my little cabin.Bottomline:
I'm still happy I bought this. I bought a second one and will see if it is as temperamental as this one. At least I now know that I have to update the firmware to get it to work properly.
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16 Cute and Clever Ways to Display Your State Pride at Home
Give some love to the place you call home with these stately pieces.
By Michelle Profis
Two States
For two lovebirds hailing from different states, this print is a super-cute way to show how far your love reaches.
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Fall General Membership Meeting (10/21/2014)
Thank you to the membership who attended the meeting as well as the members who were able to send in proxies to ensure that we had a quorum for voting on RFSRC issues. Please stay tuned to this page for news and announcements as they are made available.
Oktoberfest (10/11/2014)
The Oktoberfest celebration was a really enjoyable event (lots of great food) and we were able to welcome and meet several new families to the neighborhood. Look for additional events coming to the neighborhood after the beginning of the year and before we open the doors for the season. We're looking for additional ways to welcome new residents in our community and introduce them to the pool and discuss all of the amenities we have to offer.
And a final "Thank you"
We have such wonderful, welcoming community members living in the Ravensworth Farm and surrounding communities and we wouldn't be able to keep this pool operating without your continued support. We hope that all of you and your families enjoyed all that we had to offer. It was a pleasure to serve our community this summer and we can't wait to welcome all of you back next year.
We wish all of your families a safe and happy school year.
Your RFSRC Board


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on light duty due to illness; please contact my assistants for forum issues. They are Siu Blue Wind, or CbadRider or the other 3 star folk. I am currently at home recovering from a couple of strokes. I am making good progress, happily.
. He who fights with monsters might take care lest he thereby become a monster. And if you gaze for long into an abyss, the abyss gazes also into you.- Fredrick Nietzsche
"We can judge the heart of a man by his treatment of animals." - Immanuel Kant
Nooooooooo not Ebaum!
Every passing minute is another chance to turn it all around.


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The Perfect Server - OpenSUSE 11
Hi, i am having an issue at installing mod_ruby, any help would be greatly appreciated.
pe:/tmp/mod_ruby-1.2.6 # ./configure.rb --with-apr-includes=/usr/include/apr-1
./configure.rb:324: private method `gsub!' called for nil:NilClass (NoMethodError)
Re-installed and still get the same error
Has anyone ever had that error, i re-installed from scratch and still get the same error, tried to google it and cannot resolve, any help would be appreciated :(
I didn't have that error. Maybe you need to install another GCC version.
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Software Engineering
Department of Informatics and Mathematical Modeling - Former organisational unit. 31/12/12. Taken over by Department of Applied Mathematics and Computer Science
Aanæs, Morten
Research Assistant, Former employee
Bogetoft, Lars
External Associate Professor, Former employee
Cowan, Brian James
Section leader for Software development & GIS, Former employee
Dueholm, Mads
Software Developer, Former employee
Elk, Klaus
External Associate Professor, Former employee
Hansen, Susanne
External lecturer, Former employee


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Phil Chu and Darren Cho, the body and service specialists at AlphaWerx Auto Inc., spent years honing their automotive chops in training and apprenticeships at major manufacturers before turning their tireless work ethic to their own vehicle-perfecting institution. With a degree in auto body repair and two refinishing competitions under his belt—in which he placed first and second place—Phil decided to open his own shop and put his painstaking craftsmanship to work on collision and paint repairs. Service technician Darren Cho started out in small garages, where his passions blossomed and landed him apprenticeships working with European vehicles and later with Honda. A six-year stint at BMW fermented his knowledge and acumen for high-end cars and their entourages.
The trophies that line the inside of Royalty Auto Spa's waiting room gleam, reflecting the care the staff takes when detailing the insides and outsides of each customer's four-wheeled friend. Using only top-notch products and buckets of elbow grease, the detail-oriented car cleansers doll up dirty road-huggers with sudsy soft-cloth baths, a vacuum session, and a gentle hand dry to protect the coat. While autos undergo their pampering sessions, customers can prop their feet up in the waiting lounge and enjoy a snack or beverage while watching the TV tell knock-knock jokes.
Fine Details deals exclusively in restoring cleanliness to motor vehicles with hands-on car wash and detailing services. Erase unsightly symptoms of overuse with a full-scale hand wash with pre-rinse covering the entire hull from bow to stern. Wheels and rims regain gleams with specialized dressing, and exterior windows are clarified to minimize pesky opacity. The final gem coat paint protectant seals in restored shine and guards against pigment fade, harsh weather conditions, and acidic wit of adolescent comedians.
At more than 25 locations across Ontario, Oil Changers technicians make quick work of cars with their signature nine-minute oil change. Petro-Canada motor oil fuels this speedy lube job, a service complemented by extras such as emissions testing, headlight replacement, wiper-blade work, and maintenance services as recommended by the technicians' VIN-identifying, Henry Ford-approved scanners. With eco-consciousness in mind, these car experts embraced a closed-loop recycling program for used oil that allowed them to save the carbon equivalent of 7,324 barrels of oil in 2011.
The exhaust system is a necessity of a powerful engine, allowing cars to safely breathe out the byproducts of their daily combustion. And exhaust is exactly what the ASE-certified technicians at L&G Auto specialize in—it's the featured service at their full-service shop. Tools in hand, they help roadsters respire properly and use custom fabrication machinery to bend and weld exhaust systems onsite. The technicians can supply quality components for all makes and models, swapping out the flex pipe—often a weak point in exhaust systems—and replacing catalytic converters with an on-board Rumpelstiltskin that transforms parking tickets into gold. Alan Guo and the boys at L&G Auto also perform collision repair and cheer up cars with an encouraging array of non-exhaust services, from brake work to clutch replacements.
• For $23, you get a preventive auto-maintenance package, including oil change, brake inspection, and tire rotation (a $99.32 value, including HST). • For $79, you get a premium auto-detailing package (a $158.14 value, including HST).


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Greyhound Coloring Page
Do you know which is the fastest dog in the world? It's the greyhound! Because of their long legs, large hearts, and flexible spines, greyhounds are able to run up to 40 miles per hour. Greyhounds make great runners, but they also make great pets: they are quiet, gentle, intelligent and loyal to their owners. Color in this sweet greyhound and learn more about dog breeds!
Topics: First Grade, Animals
Updated on Sep 19, 2011
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Cambridge Bancorp Announces Another Earnings Record For Full-Year 2010
Cambridge Bancorp (OTCBB: CATC) today announced unaudited net income of $13,254,000 for the year ended December 31, 2010, representing an increase of $2,977,000 or 29.0% compared to net income of $10,277,000 for the year ended December 31, 2009. Diluted earnings per share (EPS) were $3.51, a 27.6% increase over diluted earnings per share for the prior year.
In the fourth quarter of 2010 unaudited net income was $2,654,000, compared to $2,631,000 for the same quarter in 2009.
"Results for the fourth quarter reflect continuing pressure on net interest income along with an increase in non-interest expense," noted Joseph V. Roller II, president and CEO. "Key factors driving a relatively flat quarter-over-quarter performance were a slight decrease in net interest income of $156,000, a non-interest expense increase of $413,000, offset by an increase in non-interest income of $307,000, which included an increase in wealth management fee income of $295,000, and a $250,000 reduction in the provision for loan losses as compared to the fourth quarter of 2009."
"We are pleased to report sustained earnings growth for the full year of 2010," said Mr. Roller. "Our 2010 results are evidence that we continue to build on the Cambridge Trust Company brand and operating platform that we have established through investments in people, technology, marketing, and distribution.""Deposit growth of $121.0 million (13.9%) exceeded our expectations as our relationship-based strategy, coupled with our eleventh branch opening in Lexington, created new opportunities for the Bank. Residential and commercial mortgage loan growth was solid with a $47.3 million (11.7%) increase for the year. The tepid demand for working capital loans resulted in a $10.0 million (20.8%) decrease in commercial loans outstanding due to decreased line usage and loan payoffs. While we expect to experience intensified margin pressure and regulatory burden in 2011, we are confident the strength of our company will allow us to execute on our strategies to attract and expand profitable consumer and business relationships," added Mr. Roller.
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AOL's Armstrong Sullies Reputation With On-Air Firing
"If you think what's going on right now is a joke, and you want to joke around about it, you should pick your stuff up and leave Patch today," he says.
Moments later, Armstrong apparently sees Lenz and fires him: "Abel put that camera down right now. Abel you're fired. Out."
Armstrong told investors during the New York-based company's second-quarter earnings conference call on Aug. 7 that Patch will be profitable by the end of the year. That's not that too far away. Who might be next to go?
AOL shares, which have gained 26% this year, were falling 0.6% in mid-day trading to $37.29.-- Written by Leon Lazaroff in New York >To contact the writer of this article, click here: LeonLazaroff.>.
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Moments in my life - Berlin - carnival of cultures - on the road.
Roadtrip auf der A4/ A9 Richtung Berlin...... YeahhhhaaaaaThis photo was shot on film. Taken by poepel with a Lomo LC-Wide (available in our Online Shop) loaded with DM Dia100 film in Berlin, Germany. These tags describe this photo: car, auto, berlin, kdk, carnival_of_cultures, karneval_der_kulturen, germany, deutschland, poepel, reggae, soca, dancehall, roadtrip, a4, a9, autobahn, streets, jena, gera, and leipzig. Date: 2012-05. This photo can also be found in the album Moments in my life - Berlin - carnival of cultures - part 1 - on the road.
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TV Fanatic Staff Selection, Take 4: Troy and Abed for Most Dynamic Duo!by Dan Forcella at . Comments
Who is television's Most Dynamic Duo? That's what we're asking readers to decide, and that's also the case taken up by various members of the TV Fanatic staff. So far, articles have been written that made the argument for...
- Mike and Harvey on Suits.
- Emily and Nolan on Revenge.
- Kensi and Deeks on NCIS: Los Angeles.
Now, Dan Forcella is here to defend what has to be considered the funniest pair on television at least: Troy and Abed on Community. Take it away, Dan...
Troy and Abed are the most dynamic duo on television, but I'm definitely not shocked that they're currently behind in the poll. Only three million people are watching the show each Thursday, and NBC recently Britta'd its midseason schedule by somehow NOT including this sitcom on it.
Because there are still a number of you out there who haven't witnessed the genius of Community, and specifically this fine pair, I'm here to help.
When the series first started, Danny Pudi's Abed was a bit of a budding star, while Donald Glover's Troy lurked in the background waiting for his time to shine. As the second season came into development, the two characters began to hang out more, became fast friends and the rest is hilarious history.
Troy Barnes has become one of the funniest characters on television, and while Abed has dipped a bit since his novelty factor wore out, he still has his moments... most of which come when these two are together.
Whether it be their patented bro handshake, their numerous varieties of the fake Troy and Abed in the Morning talk show (above), or Troy's unbridled joy to be friends with his socially awkward pal, these two have given us some of the most laughs on TV over the past two years/
In "A Fist Full of Paintballs," when Troy jumps out of a trash can and sees that Abed is alive and well, his goofy grin of a reaction is priceless. It was easily one of the best comedic moments in television last season.
Oh yeah! And they recently gave us the amazingly joyful "Evil Troy and Evil Aaaaaaabed," and "Troy and Abed sewn togeeeeeeeether."
These two together are without a doubt the funniest and easiest to love duo on television. Whether or not that qualifies them as dynamic is up to you the voter. All I know is that among the following group, they have my vote! Do they have yours?!?
Poll is now closed! Here are the results:Castle and Beckett - Castle
Dan Forcella is a TV Fanatic Staff Writer. Follow him on Twitter.Tags: Community, Commentary, Polls
Of course they have my vote! Love those guys!
Troy and Abed have to WIIIIIN this!!
great article Dan, love me some Troy and Abed. Especially in the mooooorning!
It's great to see Community, Supernatural and Castle all have the most votes....but Troy and Abed FTW!!!!
troy and abed in stop motion! if these two don't win there's something seriously wrong with the people who go on this sight.
Troy and Abed in the Mooorniiing!!
Looooove those two!! :) Nice article.


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text: I Am 17 Many Moons Ago Many moons ago,Was 17,Wish I were again,I know,Wind the clock back,Thirty odd years,I can be again! storywriter2 46-50 0 May 1, 2012 Me Too Your Response Please respond with authenticity, support, and respect Cancel You can join Experience Project now! Username: Password Email Birthday Gender Select Male Female Trans* Already a member? Sign In By clicking "Sign Up", you confirm that you agree to the Terms of Service of Experience Project, Inc. Login Login to respond Username: Password: Keep me logged in Not a member? Sign Up Sign Up Cancel


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White Sox righty Dylan Axelrod makes strong case to remain in rotation
BY DARYL VAN SCHOUWEN firstname.lastname@example.com May 4, 2013 10:24PM
Chicago White Sox v Kansas City Royals
SOX AT royals
The facts: 1:10 p.m., CSN, 670-AM, 97.5-FM.
The starters: Jose Quintana (2-0, 3.58 ERA) vs. Wade Davis (2-2, 5.55).
Updated: June 6, 2013 7:25AM
KANSAS CITY, Mo. — Dylan Axelrod is going to make it tough on the White Sox' brain trust when John Danks comes back.
The soft-spoken, mild-mannered right-hander was a bulldog on the mound again, allowing two runs over 72/3 strong innings against a good-hitting Kansas City Royals lineup. It was Axelrod's fourth consecutive quality start, and it left him winless at 0-2 only because his opponent was even better.
"Axelrod was good, and [Jeremy] Guthrie was better,'' manager Robin Ventura said.
Ventura said before the game that when Danks returns, his rotation could feature four lefties. If Jake Peavy is in the rotation, that would leave Axelrod — whom Ventura thinks highly of — back in the bullpen barring a trade.
Axelrod, who owns a solid 3.60 ERA, doesn't want to leave the rotation.
"No, I don't,'' he said after pitching into the eighth inning for the first time. "It's what I want, to be a starting pitcher in the major leagues. Like I said, go out there every fifth day, have a quality start, and there's nothing more I can do.''
Axelrod seems to have a lower ceiling than lefty Hector Santiago because Santiago has more electric stuff. Axelrod is a study in "knowing how to pitch.''
"I wouldn't say that about myself,'' he said. "But I have a plan every time I go out there. If that's knowing how to pitch, there it is. My gut is good, I have good instincts out there and just trust myself.''
Lots of lefties
Ventura said he wouldn't be opposed to having four lefties in his rotation when Danks rejoins the team, probably after two or three more minor-league rehab starts.
"If they're good,'' said Ventura, who could have Danks, Santiago, Chris Sale and Jose Quintana in his rotation with righty Peavy. "That's where we're at. Once you lose a guy like [right-hander] Gavin [Floyd], you're going to take a major-league arm whether they're right-handed or left-handed. Ideally, you'd like to have it split up one way or another, but we're at a point where we just need the best guys.''
The Sox are banking on Danks being one of those guys.
"We'll be looking forward to having him,'' Ventura said.
Four lefties is a lot, but it's not unprecedented. Injuries forced the Oakland Athletics to use five lefties in their rotation for a stretch during 2008: Greg Smith, Dallas Braden, Gio Gonzalez, Dana Eveland and Dan Meyer.
This and that
Dayan Viciedo (left oblique strain) took swings during batting practice. "There's a chance in the next few days that he would be going out to a [minor-league] rehab assignment,'' Ventura said.
◆ Jeff Keppinger's career average of 15.64 plate appearances per strikeout was the best among active American League players going into the season. His strikeout in the first inning Saturday night put him at eight plate appearances per K this season — with no walks.
◆ The Mets' rainout changed the pitching matchups for the Sox' two-game interleague series in New York. Matt Harvey will oppose Sale, and Jeremy Hefner goes against Santiago.
◆ The Sox announced makeup dates for their home rainouts, setting up Friday doubleheaders with the Cleveland Indians on June 28 at 4:10 p.m. and the Minnesota Twins on Aug. 9 at 1:10 and 7:10. The Tribe twi-nighter is two games for the price of one.


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What could be wrong?
Web compatibility over a coffee - notes, not slides
Notes from meetup in Stockholm
Today, we had a small meetup in Stockholm, called "web compatibility over a coffee". As it was in a café without projectors and such, I didn't prepare slides or a presentation - but I jotted down some notes, gathered some bugs to look at and some screenshots. This is basically the basis for our conversation
Why web compatibility?
- One altruistic reason - improve the web
- One selfish reason - improve the UX for browser users
The web is the most widely used programming environment. The world's greatest experiment in the capabilities and limits of human logic. A giant test suite for web browsers. And it takes two to tango: a web browser and a web site. A poor user experience is bad for a browser, whether it technically is our fault or not!
Some history:
Tech Evang component was added to Bugzilla in 2001.
Right now 1381 open bugs, of those 412 ASSIGNED
Around 14 000 bugs accumulated in component in total
Sounds like a lot of work.. why does this happen?
Well, it is a lot of work - and there are many reasons we may want to contact a site..
Old technology:
Browsers grow unexpected features sometimes:
The certainty of change:
- Mixed content blocked on https://social.technet.microsoft.com/forums and msdn pages
- cnn.com - Local news broken in Fx3.5 (depends on cross-site XHR throwing)
Pick your poison - browser-specific code:
- HuffingtonPost icon font not rendering for social/sharing buttons
- Messy rendering on Yahoo Japan mobile site
- Midflorida.com sign-in input not visible in Gecko due to WebKit CSS styling
User-Agent detection:
(Sadly, Mozilla is also doing it - we're making things worse, nudging some selected partners to look for a magic ".1" token in the version number. At the meetup, this led to a very interesting discussion about possibilities for adapting content to a device by measuring things like load- and scroll-performance, simplifying or enhancing the page correspondingly. It would certainly be interesting to see some experiments here!)
Sheer confusion:
- Reuters.com enters in an infinite loop for any mobile browsers
- google.com/green has broken sniffing for the prefix to use with "transform", ends up trying to set "trueTransform"
- finance.google.com presents null error on initial load
So, where's the frontier now?
Definitely on Mobile. The -webkit- mess. The iOS / Android duopoly which is rendering-engine-wise a monopoly. Desktop is however making a bit of a comeback due to mixed content blocking and generally stalling market share of Firefox
Any community forming?
This sort of work is both suitable and not for community building.
- Suitable because there's a lot of work to do, and much of it is just testing and outreach (i.e. doesn't need extreme technical skills).
Suitable because contributors can learn a lot from analysing code and studying the existing analysis.
- Not suitable because contributors tend to just pay attention to "their own" sites, do one or two bugs, and disappear
- Not suitable because outreach is hard, and there is often a long time to wait before you see results.
For a wider reach, we've built webcompat.com. It's becoming a cross-browser effort - all browser vendors struggle with old code, we all want the web to move forward. This helps but we still need more engaged users - and users who are prepared to stick around long-term, and work on issues across several countries, rather than just doing a few bugs or some outreach in a specific country - valuable though it is. There's also arewecompatibleyet.com which is more Gecko-centric and presents Bugzilla Tech Evangelism data in a different way.
Can we automate any of this work?
Sure. You might think of simply doing wget / curl and diff commands. You're wrong, it's much harder than that.. Here are some of my site tests which I run with SlimerJS. We're also working on using a volunteer-developed distributed infrastructure which can run tests continuously from several locations across the world. It will also support heuristics for discovering compatibility problems. This might take care of some of the boring work (testing to find problems, analysing simple issues) - and then we and the volunteers will handle the problems that require humans.
Thank you, Soumya, for organising the meetup!
CNN video redirects
Here are snippets from the JavaScript behind bug 970849, freshly served by CNN's website:
var index='/index.html',
Hm, no Mobi there? What about a Tablet? Or even better - since this is client-side already - drop the names altogether and look at width and height to figure out how to adapt the content? The problem with name sniffing is that you'll only be adapting to the few devices you already know the names of, not the millions of future devices you don't. So, no surprise that this detection fails to handle Firefox OS smartphones, for example. Not to mention the Opera Minis and Mobiles, the phones shipping Access's browsers etc.
device=String(((match instanceof Array)?match[0]:match)).toLowerCase(),
That instanceof call is a good idea though - as long as you know you might end up with device being "null".
So, want to bet that this redirMap is going to contain rules for the "null" device?
'iphone': function(){
Snipping away some complicated rules for the iPhone..
..and even more rules for the iPad.
return href.replace(path,path.replace(index,'/')+"standard.html");
This statement handles redirects for people who type cnn.com/video/ into those specific browsers this script cares about. It also does a special replace for people who type cnn.com/video/index.html. But what about users who type cnn.com/video without the final slash? Well, they don't get to see any video.. Here's what they get:
Onwards through the rest of the JavaScript:
Oh, cute - there's a special redirect for Google TVs. Somebody from the higher echelons of Google must be a Turner corporation board member or something..
And where is our "null" device handled, you might ask? Don't be silly - being forward looking is so over-rated.
if(device in redirMap) document.location=redirMap[device]();
So this part just runs the hand-picked redirect rules based on the device you're using (if they think it's worth redirecting for)..
And this confirms it's all built on top of the much abused navigator.userAgent property. As if we didn't guess that from the first .match().
So, it's official: iPhoneDroidKindle-level rich people who remember to end URLs with a slash is the only demographic the CNN cares about.
Yeah, what's the point of a big world when you have a small mind?
IE girl
Once upon a time, Microsoft wanted to promote IE9. I guess the IE6 stigma still stuck (9 is just a 6 upside down after all), so they were looking for a way to sprinkle magic coolness over the release. Enter SVG Girl - because what could sprinkle more cool than some anime with random strings of katakana? So there it is, a smooth, flashy and ultimately extremely odd animation of a girl who gets IE9 on her phone and gets … possessed. I can't think of any other way to interpret that story - IE9 seems to enter her like an evil spirit and take control of her..
IE9 is history, but when you ship code on the web it tends to stay there. So this poor possessed girl is still out there promoting IE9. She's even critical of visitors using later versions of IE - forever telling them that IE9 is the greatest thing ever. Hey - did IE9 even run on any phone in the Japanese market?
In any case, the page hangs in Firefox and Chrome. The simple reason is explained in bug 701672: when an element has id=myElm, window.myElm will typically refer to the element. IE turns out to be inconsistent for IFRAMEs, and window.myElm refers not to the IFRAME element, but to the window inside. It probably seemed like a good idea at some point..
Makes you wonder - was the coder possessed by IE9 too?
View test code on arewecompatibleyet.com
While the site arewecompatibleyet.com ships with test results from my web testing, it's until now been somewhat of a mystery how those tests actually work.
Now, even casual visitors who do not want to search through big files of code on GitHub can get a sense of how the tests work. If you scroll down to the bottom of arewecompatibleyet.com's front page, you will find a section listing all tests that output something which doesn't match the state of the bug. If a bug is closed as fixed and the test fails, or the bug is open but the test passes, it's listed.
There's a tiny new feature: a link labelled "View test code" for each entry in this table. It brings up a small box where you can not only view the test code, but also copy a chunk of JavaScript that can run from the console.
For example, there's an apparent regression on thestar.com, regarding bug 842184, no mobile content on m.thestar.com for Firefox on Android. Here's the new feature at work, showing the test code (click to enlarge):
Clicking in the grey area will select it for copying. The code you copy includes some "scaffolding" to make the test actually run - the code that is written for bug 842184 is the part inside the steps array:
var i=1, steps = [
function (){return mobileLinkOrScriptUrl() /*(regression test, expected to pass)*/ && hasViewportMeta() /*(regression test, expected to pass)*/}
function doStep(){ if(typeof hasViewportMeta !== "function"){var s=document.body.appendChild(document.createElement('script')); s.src='http://hallvord.com/temp/moz/stdTests.js'; s.onload = doStep; return;};if(steps.length){var result = steps[0](); console.log('test step '+i+' says: '+result); if(result !=='delay-and-retry')steps.shift(); i++; setTimeout(doStep,300);}} doStep();})()
The instructions say you should switch User-Agent (either with a suitable extension or through about:config) to spoof Firefox OS (that's actually a data bug since we're dealing with a bug for Firefox on Android here) and load m.thestar.com. Clicking the site link opens it in a new window.
When the site loads, we open developer tools, go to the console and paste the testing code:
As we see, the code returns false (aka 'not good'). Now we can play around with the test code - for example by removing the code calling mobileLinkOrScriptUrl() which I highlighted in the screenshot above. And voila:
So it looks like the test should no longer look for the 'mobile' keyword in file names. Unfortunately, testing the code we end up with against the desktop version of the site also returns "true". To fix this test we should dig a bit deeper and look for some difference in the DOM. It's sometimes hard to find stable features that are different - it can be an interesting challenge. Have fun if you try to help!
Testing live websites at scale
When I started working at Mozilla, one of the things I wanted to attempt was live testing against real sites - at scale. One year on, I have a sort-of-good-enough framework, over 800 tests, thousands of test results from monthlyish test runs, and a much better infrastructure around the corner thanks to the work of volunteer Seif Lotfy. It's probably a good time to document how I do my monthlyish test cycle.
I start by loading arewecompatibleyet.com, nicknamed AWCY. This site tracks Tech Evangelism bugs relating to specific websites, and associated test results.
The site has a secret feature I run from the console: a method to list all the Tech Evangelism bugs that it does not have test results for. So my first step is to open the console and type
I copy the tab-separated output data to a text editor and save it as sites.txt in a brand new folder named missing-2014-07-12.
(Well, actually - that's not true. First I paste them into the first textarea on sitedata-explorer.htm to remove any entries we have tests for already - sometimes test exist but for some reason failed to output any test results during the last test run. This means AWCY forgets that the test exists, and we risk creating a duplicate test. The output from this script does into sites.txt. I could make this step superfluous by changing the next script to check for existing tests..)
Now I'm going to run a script for playing through the URLs in a real Firefox instance, using the Mozilla Marionette automation framework. This script will attempt to generate automatic tests, and take screenshots which I can review to verify the generated tests. (In the not-too-distant future this script will retire and be replaced by Compatipede which extracts even more data points of information, enabling more varied and hopefully robust tests.)
First I run the Firefox instance I want to control, making sure I pass the -marionette argument for enabling Marionette and the -no-remote argument so it doesn't just hook up with my existing Firefox instance:
c:\Program Files (x86)\Nightly\firefox.exe -marionette -no-remote -p tester2
Having pointed testsites.py to the right directory by editing the dirname variable, I can simply do
python testsites.py
and it should run through all the data in sites.txt.
It outputs some statistics from the tests while running. The Mozilla Marionette framework (or Gecko itself) tends to hang on certain points during this process, maybe it is not always firing the right events when a site stops loading? Hence this requires a bit of babysitting - if it hangs, I'll have to resume from a specific index in the list:
python testsites.py -s 12
However, here there is a small wart in the process. The testsites.py script will generate several files: screenshots, comparison screenshots showing the site with two different user-agent strings, and sitedata-automated.js full of suggested automated tests. This file is a JavaScript file with function definitions and thus not valid JSON, and testsites.py can't currently read it. To avoid overwriting the existing data when we resume running testsites.py, I have to review those tests or stash them somewhere before resuming.
Reviewing the tests is a crucial step - I verify that the user-agent and test code looks sensible. For example, the script suggests this test:
"1003466": {
"url": "http://www.sismologia.cl",
"steps": [
function(){return hasViewportMeta() && location.hostname === "188.8.131.52" && mobileLinkOrScriptUrl();}
"ua": "FirefoxOS",
"title": "sismologia.cl sends desktop site to Firefox OS"
This looks strange - why would mobile browser be taken to an IP-address? This might be a temporary solution while the mobile site gets a proper hostname. I might decide to remove the hostname test and verify that the mobile site has META viewport and the desktop site doesn't.. Or when the script proposes this test:
"1019204": {
"url": "http://match.com",
"steps": [
function(){return hasViewportMeta() && location.hostname === "touch.uk.match.com" && hasHandheldFriendlyMeta();}
"ua": "FirefoxOS",
"title": "match.com sends simplified site to Firefox OS"
it will probably not run very well on the distributed, international infrastructure - not all machines will be in a location that match.com redirects to their UK site. This is probably a better version:
"1019204": {
"url": "http://match.com",
"steps": [
function(){return hasViewportMeta() && location.hostname.indexOf("touch.") === 0 && hasHandheldFriendlyMeta();}
"ua": "FirefoxOS",
"title": "match.com sends simplified site to Firefox OS"
Some bugs are not testable. For example, in this test run AWCY included bug 895485 in the list of bugs that require a test. This is more of a meta bug, it doesn't really describe a specific issue on a specific site, and hence we don't want a test for it. I've added a file called ignored_bugs.txt which lists the bugs testsites.py will ignore and not attempt to generate tests for. Each bug number has a comment that explains why we want to ignore that bug. Let's add 895485.
When this test run is done, when all tests in sitedata-automated.py are reviewed and copied to sitedata.js, I will also go through the generated sitedata-missing.js file. The script has prepared empty JSON blocks for all sites it could not generate tests for. For example
"1019380": {
"url": "http://www.hotels.com/",
"ua": "FirefoxOS",
"steps": [
"function(){return }"
"title": "hotels.com sends Desktop Content to Firefox OS and Firefox Android"
(First thing to do is to remove the quotes around the function - this file is valid JSON.. apologies for not hooking up a JS parser here. I do this only once a month and the script is scheduled for retirement anyway..)
Investigating, I see there's a good reason why the automation could not generate a test: the problem seems fixed! Yay! Last update on the bug is only 10 days ago, and we haven't even contacted them - but it works fine now. So testsites.py obviously did not detect any problems, but we can write a test manually and keep it around to detect regressions:
"1019380": {
"url": "http://www.hotels.com/",
"ua": "FirefoxOS",
"steps": [
function(){return location.pathname.indexOf('/mobile') === 0}
"title": "hotels.com sends Desktop Content to Firefox OS and Firefox Android"
So this test will keep running - if they tweak their browser detection again, and no longer detect Firefox OS correctly, the test will flag a failure and announce it on the AWCY site.
Finally, when the new tests are added, I'll do a test run and add test results to the AWCY site. I use a SlimerJS-based test script. I can run either individual tests:
slimerjs -P SlimerJSTester slimertester.js 1019380 1019204
or just run them all:
slimerjs -P SlimerJSTester slimertester.js
It takes quite a while to run 8-900 tests - but will eventually output results-2014-07-12.csv, and I'll add that file to AWCY's data/testing directory and update index.json to add a reference to the new file. And then the most exciting step: reloading the AWCY site to check the brand new list of fixes or regressions at the bottom of the front page..
The process still has some warts, but it works fairly well. We're testing the web at scale, and we're ready to scale even further. If you want to add or improve tests, pull requests for sitedata.js are naturally welcome!
The tests and infrastructure are not intended to be limited to Gecko/Firefox issues. With the growing, cross-browser bug list of issues on webcompat.com, now is a good time to start adding tests for other browsers' issues to our framework. Seif's "Compatipede" infrastructure will make cross-browser compatibility testing at scale even more powerful - we'll run both "exploratory" tests for various configurations and reviewed, bug-specific tests. We're in for a fun ride while scaling up!
(Edit september 2014: removed the link to the sitedata-missing file, it's now outdated.)


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Join the Mobile Myster Dinners group for a performance of "Next of Kin"!
The murder mystery will take place Saturday, April 26th at 7pm at Via!. Via! is located at 1717 Dauphin Street.
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Here's a "Next of Kin" plot summary:
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text:
Narrow down the 172 results:Map View
We have a range of budget places to stay in Cusco from as low as £3 per night
Based on previous Cusco accommodation searches, the average starting price is £27
Want to splurge? At the top end in Cusco, we have 36 places to stay with prices starting at £58
x The average starting price for a place to stay in Cusco is £27 per night.
Calle Carmen Alto 194, San BlasOutstanding 100%
Plaza Nazarenas 144 Calle PalacioOutstanding 100%
Some.Matt Friendly staff that answered questions about directions, travelling information, etc... a lively crowd of other hostellers, free wifi, a decently priced bar with drink deals and live entertainment, pressurized HOT showers... and a great location close to the Plaza. Recommended!
Cabrakancha street, Pampa de la Alianza 456 between San Agustin & Maruri st.Excellent 92%
Calle Alabado 520 San Blas CuscoExcellent 94%
Los Alamos B-6, LarapaOutstanding 100%
Jonniedetroit This hostel has a superb location, great common space, and plenty of facilities for dining, laundry and exploring in the immediate area. It is located in San Blas, the best and safest part of town. The operators have a great personality and the pisco sours are the best I have had in the country.
Calle Alfredo Yepez Miranda B-1-A Urb. MagisterialExcellent 93%
nitecall At fisrt the fact that the hostal is away from the center of Cusco seems like a disadvantage, but after seeing the other hotels and hostals that were closer to the center it became clear that this is located in a much better safer neighborhood. It is easy to get to La Plaza de Armas or any where else in the city by taxi or if your brave by omnibus, my own favorite mode of travel. The rooms and home, because it seemed more like a home than a hotel, are well maintained and clean. Sheets and towels were changed daily. There was free internet. The breakfast was varied and adequate, in fact I thought it was just right. There was also a large supermarket just a couple of blocks away it one wanted to purchase any thing. The staff were helpful and seemed to go out of their way to help. The owner even tried to teach me some Quechua. After turning on the hot water you did have to wait a while for the water to warm up, but afterwards there was plenty of hot water. Over all I would give Laramani Hostal very high marks and recommend it to anyone. It was a much greater value than I expected.
Calle Palacio 136 Plazoleta NazarenasExcellent 90%
tomasvalas Very clean facilities, in city center, and plenty of hangout areas including a pretty Spanish style courtyard. Not the place to stay if you want peace and quiet as there are plenty of partygoers, but comfy beds nonetheless. Bring a lock for the locker or find one in town.
Calle San Juan de Dios 260, 2nd floor Historical CenterExcellent 92%
Plazoleta De Limacpampa Chico - 473Excellent 90%
Create your own travel plan including Cusco as one of your stops. You can use it to store all your research (even hotels found on other websites!)
Do you have questions about Cusco? You might try asking in our active travel forums and see if anyone else has been there.
Keep your family and friends up to date with your trip by starting your own travel blog!


text:
Reading list for a better world.
Book Review: The Ownership Solution by Jeff Gates
by Gar Alperovitzposted Nov 02, 1998
- Something very important has been quietly building up in the American economy over the last few decades--something which could have portentous implications for the new century: Workers in very, very serious numbers are beginning to own the firms in which they work.
Book Reviews: The Argument Culture, Heaven's Face Thinly Veiled, The Plain Reader, The Community of the Future, by Frances Hesselbein
by Deborah Tannenposted Aug 30, 1998
- Deborah Tannen, Heaven's Face Thinly Veiled, edited by Sarah Anderson, The Plain Reader, The Community of the Future, by Frances Hesselbein
Book Review: The Voice of Hope by Aung San Suu Kyi with Alan Clements
by Jeff Shawposted Aug 30, 1998
Book Review: Toward Sustainable Communities: by Mark Roseland
by Guy Daunceyposted Aug 30, 1998
- Resources for Cities and Their Governments, by Mark Roseland reviewed by Guy Dauncey - YES! Magazine
Book Reviews: Getting a Life: Real Lives Transformed by Your Money or Your Life, by Jacqueline Blix
by Natalie Pibelposted Aug 30, 1998
Book Review: Earth Community, Earth Ethics by Larry Rasmussen
by L. A. Parks Dalozposted Jun 30, 1998
Book Review: Pythagoras' Trousers by Margaret Wertheim
by Tracy Rysavyposted Mar 31, 1998
Book Review: Carrying Water as a Way of Life by Linda Tatelbaum
by Doug Pibelposted Mar 31, 1998
- In 1977, late by her own admission for the hippie back-to-the-land movement, Linda Tatelbaum moved to 72 scrub-wood acres in Maine. a collection of essays that says little about how she stayed and much about why.
Book Review: The Cobbers' Companion by Michael Smith
by Robyn Buddposted Mar 31, 1998
- Book Review - The Cobber's Companion: How to Build Your Own Earthen Home by Michael Smith illustrated by Deanne Bednar from The Cob Cottage Company
Book Review - Losing Your Job, Reclaiming Your Soul by Mary Lynn Pulley
by Heidi Werberposted Mar 31, 1998
Book Review: On the Causes of War by Michael Andregg
by Richard Heinbergposted Mar 31, 1998
Book Review: Living Downstream: An Ecologist Looks at Cancer and the Environment by Sandra Steingraber
by Peter Montagueposted Oct 20, 1997
- A qualified scientist examines all the lines of evidence linking cancer to chemical contamination of the environment and offers solutions.
Book Review - Biomimicry: Innovation Inspired by Nature by Janine M. Benyus
by Elisabet Sahtourisposted Oct 20, 1997
Book Review- On Light Alone by Ellen LaConte
by Donella Meadowsposted Sep 30, 1997
Book Review: Cadillac Desert, by Sandra Itkoff and Jonathan Taplin
by Fran Kortenposted Sep 30, 1997
« Previous 15 items Next 4 items » 1 ... 5 6 7 [8] 9
YES! Magazine encourages you to make free use of this article by taking these easy steps., YES! Magazine. This work is licensed under a Creative Commons License


text:
Sci-Fi, Fantasy & Horror Reviews
Book Review: Late Eclipses
By Sandy Amazeen Jan 19, 2011, 21:42 GMT
October "Toby" Daye is half-human, half-fae-the only changeling who\'s earned knighthood. But when someone begins targeting her nearest and dearest, it becomes clear that Toby is being set up to take the fall for everything that\'s happening. ...more
Immediately after half-breed fae October Daye received an unprecedented title from the Summerlands Queen, Lily a dear friend and Lady of the Tea Gardens takes ill. As an Undine, Lily should be impervious to any illness yet her life is clearly, impossibly ebbing away. Daye pledges to keep Lilys people safe but with other faeries including her lieges
wife Luna becoming ill it is a promise she will be hard pressed to live up to. An urgent summons by Tybalt the local King of Cats reveals most of his court gravely ill and if Daye cannot find out why, it could spell the end to the Court of Cats. Nothing is certain beyond the distinct impression that somehow Oleander is behind it.
Thanks to a complex spell cast by Oleander, Daye spent years living as a goldfish before the spell was countered and by that time all hope of reestablishing a relationship with her husband and daughter was gone. Living up to her name, Oleander seeks to kill everyone Daye holds dear but to what end? The Queen of the Mists, Oleander and the Kings own daughter spin a web of treachery and deceit that leaves Daye doubting her sanity even as she must make the most difficult choice a second time.
Brisk pacing, a delightful mix of characters and assorted family issues make for an entertaining read that grabs your attention and doesnt let go to the very end. Dayes relationship with Tybalt and her mother add a humanizing touch while hinting at a more complicated heritage then suspected. The general dark tone is lightened by touches of black humor while the subtle attraction between Daye and Tybalt add hints of romance without overplaying it. This is a strong addition to the series which is best enjoyed from the beginning while leaving readers to wonder whats next.
Like this article? Please share on Facebook and give Monsters & Critics a "Like" too!
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text: Discussion and debate with Joe Duffy More callers talk to Joe about their experiences with the debilitating condition Ehlers–Danlos syndrome (EDS). David Duffy of Duffy's circus talks about the reduction in grants to circus from the Arts Council. Ann Walker has closed her wedding dress business due to the high cost of rent and rates. She is now looking for a pop-up shop to sell off her stock.http://www.rte.ie/radio1/liveline/programmes/2014/0109/496833-liveline-thursday-9-january-2014/?clipid=1391020


text:
Austin News
Local news for Austin, TX continually updated from thousands of sources on the web.
Smoldering fireplace ash causes South Austin apartment fire
1 hr ago | KXAN-TV Austin | Comment?
Where to eat in Austin on New Year's Eve
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a Controversiala Austin water plant opens
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Austin news feed: Best booze of 2014, Qui and Franklin dream dinner plus more
22 hrs ago | CultureMap | Comment?
Man charged in 2009 North Austin sexual assault
Yesterday | Austin American-Sta... | Comment?
Families of victims of fatal SXSW crash sue organizers
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Austin pet shelter gets extension on code compliance
Yesterday | KXAN-TV Austin | Comment?
Austin police officer resigns after making 'whore' comment to local reporter - on tape
Yesterday | CultureMap | Comment?
Puppy found unharmed after fire destroys Austin home
Yesterday | KXAN-TV Austin | Comment?
New East Austin restaurant deemed one of the best in the country
Yesterday | CultureMap | Comment?
Keep Austin Gray? Austin and Fredericksburg named top places in U.S. to retire
Thursday | CultureMap | Comment?
Raising Austin: Saying goodbye to 'Clifford' creator
Thursday | Austin American-Sta... | Comment?
Boyhood' takes top honors from Austin critics
Thursday | Austin American Sta... | Comment?
Securimate Chooses Austin, TX, for Its Headquarters
Wednesday | AndhraNews | Comment?
Austin press screening of 'The Interview' cancelled amid terror...
Wednesday Dec 17 | Austin American Sta... | Comment?
Mansion that 'almost killed' Texas architect on sale for $6.5 million in Austin
Wednesday Dec 17 | MySanAntonio.com | Comment?
Updated: Sat Dec 20, 2014 03:20 pm
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text:
20 Ultimate LEGO Movie and TV Inspired Builds (list)
It's amazing how a simple toy like LEGOs can be turned into a masterpiece! You can build practically anteing imaginable with LEGOs, including some pretty cool movie and TV show-inspired creations! From life-sized Batmans, Stormtroopers from Star Wars and more, here are some of the coolest LEGO builds that were either inspired by movies or TV shows and are definitely made from thousands upon thousands of various LEGO blocks.
20. SpongeBob SquarePants
19. Madagascar Penguin
18. Batman and Robin
17. Shaun of the Dead
16. Life-size Batman
15. Life-size Indiana Jones
14. Life-size Startrooper
13. Winnie the Pooh
12. Predator
11. Conan O'Brien
10. Harry Potter
9. Buzz and Woody from Toy Story
8. Captain Jack Sparrow from Pirates of the Caribbean
7. Lightening McQueen from Disney's Cars
6. Lord of the Rings Battle scene
5. Star Wars R2-D2
4. Star Wars Battle of Hoth
3. Star Wars Invisible Hand Ship
2. Star Wars Droid Control Ship
1. Star Wars Millennium Falcon
Kristie Bertucci
Kristie Bertucci is an L.A.-based writer, who can't live without her MacBook Pro. When she's not writing, she's either reading or shopping (online, of course) and loves lazy days so she can catch up on her DVR-recorded shows and movies. She's definitely a Mac girl, she loves music and is currently on a mission to to have an insane and enviable iTunes library.
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1 Comment to 20 Ultimate LEGO Movie and TV Inspired Builds (list)
Pic 9 is Ron Weasley, not Harry Potter. Better change that before the fanboys whip out their pitchforks. (excellent pics btw. Loved them!)


text:
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JFK Website (0)
Digital Archives (1)
Sortable End Date: 19690109
Beaty discusses conflicts of interest between current and former government employees and industry; public works projects including desalinization, dams, and tidal power; relations between the U.S. and Mexico over water rights to the Colorado River, among other issues.
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text:
|Gaming Board
|Return to Board Menu Bottom
|Page 2 of 2
|re: Hardest games to complete 100%
Posted by RonBurgundy on 1/20 at 3:47 am to THRILLHOSuperman on N64
Reply Back to Top
Posted by CajunBandit on 1/20 at 3:56 am to DoUrden
quote:If you are on pc you can use a savegame editor and give yourself all the elements you need. Saves loads of time, but it can imbalance gameplay until later into the game.
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Posted by elprez00 on 1/20 at 8:38 am to Mr GardokiI played AC 1. I liked it. Got AC 3 for Christmas. I am really disappointed. Walk here, 5min cutscene. Ride a horse there, 10 min cutscene. I'm seriously considering not finishing it and trading it in.
To the OP, GTA San Andreas.
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Posted by Mr Gardoki on 1/20 at 8:48 am to Brosef Stalin
I did everything in AC2 except collect all the flags, I wasn't about to take the time to do that. I am playing brotherhood right now and I do as much as I can but there are some missions i got tired of replaying trying to get 100%.
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Posted by Mr Gardoki on 1/20 at 8:49 am to elprez00
I didn't even come close in that one. GTA is a cool enough game though that you can pick it up and replay it whenever you want so sometimes I go back and knock a few things out to up my percentage.
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Posted by JombieZombie on 1/20 at 3:07 pm to jmarto1
you can say the same about Skyrim. There's alot to do and explore but the main quest is basically a Nord GTA.
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Posted by GeauxWarTigers on 1/20 at 3:18 pm to SundayFunday
This gets my vote.
Never have I found a game that made repeatedly beat my head into the same wall so much.
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Posted by CornDogCologne on 1/20 at 4:28 pm to GeauxWarTigersI have relatively few games with 100% completion.
Usually a handful of extremely tedious achievements/tasks that hold me back.
Fallout 3 was one of the few that I went all the way with, oddly enough.
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Posted by BaddestAndvari on 1/20 at 4:31 pm to DoUrden
the original Mass Effect was muuuuuuuch harder
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Posted by LosLobos111 on 1/20 at 6:56 pm to DoUrdenXenoblade
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Posted by Matisyeezy on 1/20 at 10:24 pm to BaddestAndvari
Seriously. Exploring all of the planets to the max could be frustrating at times.
And to the person who said Xenoblade, I'm currently playing Xenoblade Chronicles and...holy crap. The side quests. Can get frustrating at times, but at this point I'm too far in to abandon ship
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Posted by R_o_y on 1/21 at 8:32 am to MatisyeezyWell, theoretically, you can't complete Skyrim at 100 percent due to the Radiant quest system. The game will produce infinite quests.
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Posted by ILikeLSUToo on 1/21 at 12:36 pm to R_o_yYep, there will always be someone out there who's so tired she could just fall asleep forever.
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