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Hole in the Wall Restaurants, Part V
Updated On: May 05 2014 12:24:11 AM EDT
A Hole In The Wall "scandal"? A few months ago a thread was launched on Yelp about the "Hole in the Wall" series. Why? Well, I felt totally free to use some of the images associated with the chosen restaurants from the Yelp site.
A few of the end users of Yelp were not too happy to see their images posted without recognition. That is understandable. I should have provided attribution. To those whose images I used without properly crediting, I apologize.
A reuben from one of Jacksonville's "Hole in the Wall" restaurants
With that said, it has been a long time since the last series. I'm excited about this installment. I'm continually blown away by Jacksonville's unique restaurant heritage. We have some of the oldest deli's in this city and I think we have a couple of pretty solid niches; mainly, Vietnamese and Jamaican/Caribbean.
In this installment I picked out four more Jacksonville restaurants that I think stand out. Let me know what you think.
Hole in the Wall Restaurants to Check Out
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E1Similar to the North American T-1, E1 is the European format for digital transmission.
E1 carries signals at 2 Mbps (32 channels at 64Kbps, with 2 channels reserved for signaling and controlling), versus the T1, which carries signals at 1.544 Mbps (24 channels at 64Kbps). E1 and T1 lines may be interconnected for international use.
Tape clearly is on the decline. But remember, legacy systems can hang for a shockingly long time. Read More »Apple Pay Promises to Strengthen Payment Security
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To make the IoT both work and pay off, IT is juggling upgrading and building app-centric networks, mapping out new data center architectures and... Read More »
The trend for the past two years has been for shoppers to spend more online during the holiday season. How do you typically shop for holiday... Read More »How to Create a Desktop Shortcut to a Website
This Webopedia guide will show you how to create a desktop shortcut to a website using Firefox, Chrome or Internet Explorer (IE). Read More »Flash Data Storage Vendor Trends
Although it is almost impossible to keep up with the pace of ongoing product releases, here are three recent highlights in the flash data storage... Read More »
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Human Subjects Research in the News
December, 2014
NIH takes step to speed the initiation of clinical research by ensuring use of single IRB
National Institutes of Health
The National Institutes of Health issued a draft policy today to promote the use of single institutional review boards or IRBs, in multi-site clinical research studies. IRBs play a critical role in assuring the ethical conduct of clinical research, and studies must be reviewed and approved by an IRB before they can begin. When the regulations for protection of human subjects were first published, most clinical research was conducted at a single institution. Since then, the research landscape has evolved, and many studies are carried out at multiple sites and within large networks. Studies that go beyond a single site are often able to recruit more individuals from diverse populations. These multi-site studies can often generate important results in less time. However, working through IRB review at each site can add delay without increasing the protections for the research participants in the study.
Scientists Often Skip A Simple Test That Could Verify Their Work
That omission is a problem. One study found that between 18 percent and 36 percent of all cell lines have been misidentified. And this kind of mistaken identity is one reason that many results from experiments run in scientific labs can't be reproduced elsewhere.
"These are really not very easy discussions to have," says Leonard Freedman, founding president of the Global Biological Standards Institute. "Irreproducibility is kind of an uncomfortable subject to talk about, particularly among researchers."
Mistaken Identities Plague Lab Work With Human Cells
November, 2014
NIMH creates new unit to support its research domain criteria initiative
National Institutes of Health
The aim of the RDoC initiative is to accelerate the pace of research that translates basic science into clinical settings by understanding the multi-layered systems that contribute to mental function. The RDoC approach emphasizes neurodevelopment and environmental effects, in keeping with modern views about the genesis of mental disorders.
No safety concerns yet in trials of GSK's Ebola vaccine
The experimental shot uses a single Ebola virus gene from a chimpanzee virus to generate an immune response. Because it doesn't contain any infectious virus material, it can't infect those being vaccinated.
HHS and NIH take steps to enhance transparency of clinical trial results
National Institutes of Health
The U.S. Department of Health and Human Services today issued a Notice of Proposed Rulemaking (NPRM), which proposes regulations to implement reporting requirements for clinical trials that are subject to Title VIII of the Food and Drug Administration Amendments Act of 2007 (FDAAA). The proposed rule clarifies requirements to clinical researchers for registering clinical trials and submitting summary trial results information to ClinicalTrials.gov, a publicly accessible database operated by the National Library of Medicine, part of the National Institutes of Health. A major proposed change from current requirements is the expansion of the scope of clinical trials required to submit summary results to include trials of unapproved, unlicensed, and uncleared products.
NIH and FDA Toughen Rules on Reporting Medical Trials
National Institutes of Health
October, 2014
The FDA takes steps to strengthen cybersecurity of medical devices
U.S. Food and Drug Administration
The FDA's concerns about cybersecurity vulnerabilities include malware infections on network-connected medical devices or computers, smartphones, and tablets used to access patient data; unsecured or uncontrolled distribution of passwords; failure to provide timely security software updates and patches to medical devices and networks; and security vulnerabilities in off-the-shelf software designed to prevent unauthorized access to the device or network. The FDA has neither an indication that specific devices or systems have been purposely targeted, nor reports that any patients have been harmed as a result of cybersecurity breaches, but remains concerned about device-related cybersecurity vulnerabilities and their potential to adversely impact public health.
NIH Announces First Wave of Funding for BRAIN Initiative Research
Calling it "the beginning of an ambitious journey", the National Institutes of Health announced its first wave of grants in support of the BRAIN Initiative. This initial round of awards totals $46 million to support the goal of developing deeper understanding of the brain that will ultimately catalyze new treatments and cures for devastating brain disorders and diseases.
Can Big Data Tell Us What Clinical Trials Don't?
The New York Times
After Election 2014: Biomedical Funding
Science Insider
Regardless of which party ends up controlling the Senate, the research community is unlikely to abandon its embrace of the innovation deficit as a persuasive tool in funding battles. (A coalition of scientific societies, including AAAS, publisher of ScienceInsider, has even created a website for the concept.) More money for research is only part of the pitch, however; groups are also using the phrase to highlight the importance of steady, predictable growth in the research enterprise.
In applauding Harkin's bill, for example, the Association of American Medical Colleges touches on both ideas. Its leaders cite the need "not only to restore the purchasing power the NIH has lost to inflation over the past decade, but also to provide the sustained, long-term predictable funding growth essential to catalyze scientific momentum and address current and emerging health challenges."
September, 2014
Health Researchers Will Get $10.1 Million to Counter Gender Bias in Studies
The New York Times
Women are not adequately represented in many clinical trials of new drugs and medical devices. The gender bias starts at an early stage of the scientific process: Traditionally many investigators have worked only with male lab animals, concerned that the hormonal cycles of female animals would add variability and skew study results.
Washington Highlights NCATS Announces Changes to CTSA Program
Association of American Medical Colleges
First Vaccine for Dengue Fever Shows Promise in 2nd Big Trial
The New York Times
The number of dengue cases has been increasing rapidly worldwide in part because of urbanization, since the mosquito that carries the disease is well adapted to urban areas. Dengue is even moving out of tropical areas in developing countries to industrialized countries in more temperate zones.
Sanofi said that in the second trial, as in the first, the vaccine was more effective in people previously exposed to dengue. That might make the vaccine especially useful in endemic areas, where people often are exposed more than once, but it would probably make it less useful for tourists traveling to an infected area.
Can Big Data and patient-informed consent coexist?
A physician studying a relatively rare disease, meanwhile, could easily recruit thousands of, say, cystic fibrosis patients from a database that included millions of people. "I will no longer have to spend years recruiting 3,000 patients for a study, because I will already have 10,000 banging on the door," says Michael Lauer, director of the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute.
Fantasy Video Game Teaches Kids About Clinical Trials
"The Paper Kingdom is a novel approach, adapting an established media platform to the need for conveying important educational content to kids," Marceau says. "This is the kind of innovative synthesis of technology and public health research at which NERI excels."
AAMC Responds to FDA's Draft Guidance on Informed Consent
Association of American Medical Colleges
The AAMC urged the FDA to "consider this guidance document an opportunity to reinforce that a document capturing required elements of informed consent is only a component of the ethical obligation to ensure that research subjects have meaningful awareness of what their participation in a clinical trial means to them," and expressed concern that the draft guidance could result in longer documents for potential research subjects.
Ebola: Volunteer Opportunities to help
American Society of Tropical Medicine and Hygiene
IMMEDIATE NEEDS: Both Wellbody and Last Mile are looking for a few long term volunteers to help with the current activities of community outreach and primary health care stewardship in this environment including:
- Physicians who can do health facility preparedness, training at hospital level on Ebola case isolation and setting up isolation/referral pathways
- RNs who can do community-based training, support management for CHWs & Primary Health Care Centers
- Experienced health systems professional to support staffing to MoHs national incident management committee (ideally health systems background)
August, 2014
Learning to Do Research the Hard Way
Inside Higher Ed
An interesting conversation about evolving understandings of research ethics in library sciences. From the article:
Librarians who are largely DIY researchers have two models in front of them: the scholar's way and the corporate way. We're used to learning how to improve web designs from tech blogs. We've designed surveys based on the advice of marketing gurus. We know that Google and Amazon and Facebook violate privacy in troubling ways, but since they set the standard for UX we sometimes think it is time we stopped being so fussy about privacy.
As Ebola's Toll Rises, Drug Makers Race to Test Medicines
New York Times
From the article:
But with the largest ever Ebola outbreak now having killed more than 1,000 people in West Africa, drug companies and doctors are scrambling to see whether any existing medicines or drugs under development can help stem the epidemic.
Co-Workers Take Dim View of Women Who Seek Flex Time: Study
Medline Plus NIH
From the article:
When employees asked to work from home for childcare-related reasons, nearly 70 percent of participants said they would be "very likely" or "likely" to approve the request if it was made by a man. But only about 57 percent said they would grant the request when made by a woman.
In these cases, 24 percent of participants said men who made such a request were "extremely likeable," while only 3 percent of participants said women who made such a request were "extremely likeable."
Ebola, Ethics, and Public Health: What Next?
Annals of Internal MedicineFrom the article:
Drug testing requirements are designed to ensure that drugs are sufficiently safe and effective to be recommended to the public. No such evidence exists for these drugs. Moreover, U.S. researchers have been accused many times of exploitation (including of poor people in Africa) when testing new treatments during devastating public health outbreaks (6-8).
July, 2014
Discovery at U of I Will Help Doctors Predict Preeclampsia
This discovery utilized specimen banking, as described in the article:
The biomarker discovery comes after 2 years of research. But researchers say it would have taken much longer if they hadn't been able to get samples from the Maternal Fetal Tissue Bank at the U of I. The bank keeps samples of things like blood, tissue, and urine that pregnant women, who agree to take part in the study, give during their routine visits.
June, 2014
Symbolic Slap at Social Sciences
Inside Higher Ed
From the post: The U.S. House of Representatives early Friday morning approved an increase in overall funding for research at the National Science Foundation but also endorsed an effort to pare social science studies that the agency funds.
7 Tesla MRI scanner installed
The Loop UI Health Care
From the article: The scanner will produce high-resolution images of microscopic structures within the human body and brain, allowing researchers to measure subtle changes in the size, function, and metabolism of specific brain structures associated with disease. For example, the scanner will let researchers measure tiny fluctuations in blood flow and metabolic processes that signal differences in brain activity. UI researchers will use the 7T scanner to investigate how the brain processes sound information; look at subtle abnormalities in white matter caused by brain disease and trauma; and detect age-related brain changes that affect decision-making.
Gender-specific research improves accuracy of heart disease diagnosis in women
American Heart Association
Killing a Patient to Save His Life
New York Times
From the article:
"scientists have never tried anything like this in humans, and the unconscious patients will not be able to consent to the procedure. Indeed, the medical center has been providing free bracelets to be worn by skittish citizens here who do not want to participate should they somehow wind up in the E.R...
In order to obtain an exemption to federal informed consent rules, the hospital held two town hall meetings on the university campus, placed advertisements on buses, and made sure the news got in newspapers catering to minority readers."
May, 2014
BC's Irish project leads to arrest of Gerry Adams
Boston Globe
An oral history research project on the conflict in Northern Ireland at Boston College leads to an arrest of Sinn Fein leader, Gerry Adams. Two participants in the project implicated Adams in their taped interviews; they had agreed to interviews with the understanding that information would be kept confidential until their deaths.
Research Ed Moloney, a journalsit who worked on the Belfast Project, expressed concerns about the subopena for the research records. From the article:
"The damage is done," he said. "The whole process of conducting academic research in the United States of America on sensitive subjects with confidential sources has been dealt a death blow..."
April, 2014
Grants: Funder storm
From the article:
The outlook has brightened somewhat, however: in January, Congress released a 2014 spending deal that suspended sequestration for two years and slightly boosted the budgets for the US National Science Foundation (NSF) in Arlington, Virginia, and the US Department of Energy (DOE) Office of Science over 2012 levels. The NIH, however, took a US$800-million cut, continuing a ten-year downward trend (see Nature 505, 461–462; 2014).But some observers worry that last year's trauma will continue to influence the attitudes and decisions of scientists in training for some time. "A graduate student who looks at their principal investigator and sees how much trouble they're having is discouraged from going out into academia and setting up their own lab," says Laurie Glimcher, dean of Weill Cornell Medical College in New York City. "I'm sure we're going to lose some of the next generation of scientists."
Most Medical Devices Approved for Kids Only Tested on Adults: Study
HealthDayFDA evaluates all devices for safety and effectiveness based on the indications and data provided by the sponsor, Laine said."Because of the small populations involved in pediatrics, many devices may be approved by the Humanitarian Device Exemption pathway, which provides an alternate marketing path if certain criteria are met for rare conditions," she said. "The FDA considers flexible and adaptive clinical trial designs when reviewing devices in any small population. Additionally, the FDA takes into consideration the availability of alternative treatment options."For the study, the researchers looked at the pre- and post-market testing of devices the FDA considers Class III, or high risk.
March, 2014
Women Still Left Out of Medical Research: Report
Medline Plus
From the article: "while women are now more routinely included in clinical trials and an entire field of women's health has emerged beyond reproductive health, "there are still enormous gaps in the scientific process as it relates to women," said Johnson, who is executive director of The Connors Center for Women's Health at Brigham and Women's Hospital in Boston."
Living With Cancer: The Cost of Trials
New York Times
Phase 1 Clinical Trial participant describes an experience with a trial-required CT scan. Be sure to read the interesting comments.
February, 2014
UI receives $17 million for automotive safety research
Iowa Now
Several projects will receive funding from this grant, including one of the first comprehensive consumer driving surveys.
The Long Tail for Biomedical Research
Columbia Business School
The United States devotes a lot of money to developing biomedical innovations: combined, the public and private sectors spend about 140 billion dollars on medical research every year. The Federal Government, primarily through the National Institutes of Health (NIH), does very basic upstream research, while private industry does more applied research to translate it into treatments and commercialize it, such as developing new drugs.
January, 2014
Drivers engaged in other tasks about 10 percent of the time
From the article: Risks of distracted driving were greatest for newly licensed teen drivers, who were substantially more likely than adults to be involved in a crash or near miss while texting or engaging in tasks secondary to driving, according to the researchers from the National Institutes of Health and Virginia Tech.
Study: Two-sizes-too-small 'Grinch' effect hampers heart transplant success
Iowa Now
Current protocols for matching donor hearts to recipients foster sex mismatching and heart size disparities, according to a first-of-its kind analysis by physicians at the University of Maryland School of Medicine and the University of Iowa. Matching instead by donor heart size may provide better outcomes for recipients, who already face a scarcity of resources as they await a transplant.
Ease Up on Social Science
Inside Higher Ed
The article discusses DHHS proposed revisions to the Common Rule, and the implications--positive and negative--for Behavioral and Social Sciences researchers.
December, 2013
UI selected for nationwide stroke research network
Iowa Now
From the article:
"The new system is intended to streamline stroke research by centralizing approval and review, lessening time and costs of clinical trials, and assembling a comprehensive data sharing system," said Dr. Petra Kaufmann, associate director for clinical research at the National Institute of Neurological Disorders and Stroke (NINDS) in a prepared statement. NINDS will fund and manage the NIH Stroke Trials Network, or NIH StrokeNet.
Avid Cellphone Use by College Kids Tied to Anxiety, Lower Grades
Medline Plus
From the article:A new study suggests that college students who can't keep their hands off their mobile devices -- "high-frequency cellphone users" -- report higher levels of anxiety, less satisfaction with life and lower grades than peers who use their cellphones less frequently.If you're not college age, you're not off the hook. The researchers said the results may apply to people of all ages who have grown accustomed to using cellphones regularly, day and night.
Clots Tied to Heart Pump Open Debate on Risks Patients Face in Trials
New York Times
2013 Research Highlights
A list of clinical breakthroughs, promising medical advances, and insights from basic research in 2013.
Medical trials for kids don't always match global need
From the article:
"We have this laissez-faire attitude of how health research will precede - that companies, government and foundations will identify the most important areas to do trial and analyses," Dr. Clay Johnston said. "This type of research shows that doesn't happen as well as we'd like."
November, 2013
National Advanced Driving Simulator receives grant
Iowa Now
NADS is a center for driving simulation excellence located at the UI's Research Park in Coralville, Iowa. The facility is home to a range of simulators that offer varying levels of driving realism.
NADS employees are a collection of experts unmatched in their experience in working with all aspects of driving simulation. Development and research conducted at the NADS—sponsored by government, military, and industry partners—save lives, improve quality of life for motorists, advance the state of the art in driving simulation, and improve the efficiency and productivity of the vehicle manufacturing sector.
Psychology graduate students win dissertation grants for human subjects research
Iowa Now
One of the projects described in the article:
Zhen Wu has been awarded a grant from the National Science Foundation to support her dissertation research. The title of her project is "Doctoral Dissertation Research: How Does Pointing Facilitate Word Learning?" Her research will address how and why pointing influences young children's word learning in real-time contexts. Wu is working under the supervision of Julie Gros-Louis, UI assistant professor of psychology.
Doctors Say Heart Drug Raised Risk of an Attack
New York Times
Article highlights concerns with data sharing in an industry sponsored clinical trial. From the article:
Studies and lawsuits have shown that many clinical trial results, particularly negative ones, are not published. Critics say that hampers medical practice and violates an obligation to patients, who try experimental treatments in part to advance knowledge.
Youth football and concussions: Worth the risk? UI Sports Medicine study will compare injury rates for youth flag and tackle football
Iowa Now
"Given the increased media attention to youth tackle football, we have had many patients inquire about the injury risk of tackle football and/or whether flag football was safer or recommended," Smoot says. "Seeing no data to adequately address these questions, we decided to look at our own region (in eastern Iowa, tackle football is available in some areas for second graders through junior high age; most junior highs have tackle programs)."
October, 2013
Clinical Trials Continue, but Only at a Crawl
New York Times
From the article:
While enrollment has slowed significantly, it has not stopped. On Wednesday, more than a week into the shutdown, N.I.H. officials said that the agency had continued to admit critically ill patients to existing clinical trials, of which more than 1,400 run at any given time. About 12 patients were enrolled between Oct. 1, when the government shutdown began, and Oct. 8. Most were cancer patients, said Renate Myles, an N.I.H. spokeswoman.
Iowa cancer researcher denied federal funds, but gets grant instead
Improving colon cancer screening rates in Iowa Main Page Content Mailing educational material and a testing kit to patients more than tripled screening rates
Iowa Now
"Mailing educational materials and FIT kits directly to patients in primary care practices across Iowa led to much higher colon cancer screening rates compared with usual care," Levy says. "The results suggest that mailed education along with fecal immunochemical tests may save lives by increasing the early detection of colon cancer. Practices and health care systems wishing to increase colon cancer screening rates should consider systematically mailing information and the take-home test to patients due for colon cancer screening. We would encourage people to talk with their health care provider about getting screened for this potentially preventable disease."
September, 2013
UI gets set to welcome powerful new scanner
Iowa Now
"The UI will be one of only about 20 research institutes with the instrument."
Patient Outcomes Improved by Pay-For-Performance
NIH Research Matters
An interesting project attempting to assess how physician incentives affect long-term outcomes. From the article:
There were 4 key quality goals. All are known to reduce long-term cardiovascular risk: aspirin or antithrombotic medication prescription, blood pressure control, cholesterol control, and smoking cessation interventions. For the P4P clinics, a financial incentive was paid to physicians when a patient met a quality goal. Incentives were tiered; higher payments were given when patients who were sicker, or who had Medicaid or were uninsured, met goals. Maximum payments were $200 per patient and $100,000 per clinic. The effects were assessed from April 2009 through March 2010.
UI vaccine unit wins multimillion dollar federal contract
Iowa Now
From the article:
"The capability to respond to emerging diseases is extremely important and this national network of VTEUs allows us to rapidly test vaccines in response to potential pandemic threats," Winokur says. "By conducting trials throughout the VTEU network we also can identify the roadblocks that might impair rapid response in a pandemic setting."
August, 2013
NIH, Lacks family reach understanding to share genomic data of HeLa cells
NIH News
"Besides their priceless contributions to biomedical research over the past 60 years, Mrs. Lacks and her family are now serving as a catalyst for policies that advance science, build trust, and protect research participants," said Dr. Hudson.
July, 2013
Is It Safe to Take Medication While Pregnant? It isn't unethical to test drugs on pregnant women. It's unethical not to
From the article:
Pharmaceutical companies are not willing to navigate the legal and ethical minefield of testing drugs on pregnant women, especially because pregnancy lasts only nine months, a short window in which the tests could pay off in additional sales. As a result, drugs are often prescribed to this population off-label, meaning that they haven't been specifically approved for pregnant women. The editors of the Drug and Therapeutics Bulletin argue that not only is enrolling pregnant women into drug trials important, it's unethical not to do so. The authors of a New England Journal of Medicine review of how pregnant women were treated during the H1N1 flu pandemic say such research "is not only permissible but also imperative."
June, 2013
Supreme Court says genes can't be patented; patient advocates and researchers cheer
NBC News
"While companies are free to use the genes as a starting point to develop tests and treatments, the genes themselves should remain in the "public storehouse of knowledge" for scientists and companies to study and use, the ACLU said in a blog post."
May, 2013
PCBs are everywhere
Iowa Now
"This is not good news, and it certainly applies to all of us," says Keri Hornbuckle, professor of civil and environmental engineering in the UI College of Engineering and senior author on the paper. "I thought it would be worse in a very industrial city than in a rural community. Our results really shook us up. We all have PCBs in our blood, and they are coming from somewhere. We don't make them in our bodies."
Psychology Is WEIRD: Western college students are not the best representatives of human emotion, behavior, and sexuality
The author questions the tendency of social/behavioral scientists to rely upon homogenous research subject pools.
From the article:
"WEIRD is the phenomenon that plagues a lot of psychology and other social science studies: Their participants are overwhelming Western, educated, and from industrialized, rich, and democratic countries. They're WEIRD. And not only are they WEIRD, they are overwhelmingly college students in the United States participating in studies for class credit. Thinking about the source of the data for a lot of hyped, overinterpreted psychology research puts the results into a whole new light."
Children of Long-Lived Parents Less Likely to Get Cancer
Science Daily
Longevity isn't the only genetic benefit of long-live parents; resistance to cancer, diabetes and stroke are also indicated. Additionally, "these protective effects are passed on from parents who live beyond 65 -- far younger than shown in previous studies, which have looked at those over the age of 80."
March, 2013
Federal Overhaul of Rules for Human Research Hits Impasse
The Chronicle of Higher Education
From the article:
The government has received more than 1,100 public comments on the rule-change ideas, suggesting heavy interest in change, Mr. Schrag said. The fact that the revision process involves multiple agencies helps explain why success may be even tougher in this case than in rules changes involving a single agency, he said.
US bioethicists recommend more tests before child anthrax vaccine trials
Nature News Blog
Addressing risk, from the article:
...clinical trials are not normally conducted in children unless there is a chance that children can benefit from the trials. And the risk of a bioterror attack is uncertain, making such trials ethically complicated.
February, 2013
January, 2013
Extroverts not always team players
Iowa Now
40 Years After Tuskegee: Reuniting Medical Research and Practice
An interesting examination of current ethics regulations, from the article:
For almost forty years, maintaining a sharp distinction between medical research and medical practice has been the cornerstone of biomedical ethics and the federal regulations that oversee how research with human subjects is conducted. The need to build a firewall between research and practice emerged during a period of intense societal focus on egregious violations of human rights that occurred in research, including most notably the Tuskegee Syphilis Study. The dominant concern then was to protect patients and other subjects from risky and exploitative research.
Today, however, the segregation model we put in place to protect patients is actually harming them.
'Rehab' helps errant researchers return to the lab
How to handle scientific research misconduct? From the article:
"Sometimes these are very talented researchers," says James DuBois, an ethicist at Saint Louis University, who leads the rehab programme, called RePAIR (Restoring Professionalism and Integrity in Research). "We believe that if we can equip them with certain skills, they can return to the field as very productive individuals."
Twice the Price
An editorial in the journal Nature describes why "scientists everywhere should be disturbed that two separate pieces in Nature this week report on the lack of oversight of potential waste and overlap between research grants."
Published clinical trials shown to be misleading
Science News
From the article:
In comparing public and private descriptions of drug trials conducted by pharmaceutical giant Pfizer, researchers discovered discrepancies including changes in the number of study participants and inconsistent definitions of protocols and analyses.
Fighting Cancer: Better Models Make Better Drugs
Huffington Post
December, 2012
November, 2012
Does Gender Warp Our View of Depression?
Health Magazine
A University of Iowa study says men are less likely to be seen as depressed—even when they are. James B. Potash, MD, study editor and UI professor of psychiatry, says there has been relatively little focus on education and depression in men.
Sanctions imposed in 2004 U drug trial death
Minneapolis StarTribune
Article discusses tragic outcome for subject of drug trial, raises concerns about issues of informed consent.
Scientists Hope Obama Continues Support for Basic Research
New York Times
Federal agencies like the National Institutes of Health, NASA and the National Science Foundation would all see their budgets drop by about 8 percent, if the "fiscal cliff" leads to tax cut expirations.
Empowering Patients through Informed Consent
From the article: In assessing the advancing field of whole genome sequencing, the Commission recommends protecting and empowering patients through the "evaluation and adoption of a robust and workable informed consent process." Informed consent is more than a form to be signed; it is a process that involves an active discussion between patient and clinician or researcher. Informed consent is a demonstration of respect for persons, the ethical principle that serves as the cornerstone of the Commission's report.
Malaria Vaccine Candidate Gives Disappointing Results
New York Times
From the article:
Like an H.I.V. vaccine, one against malaria has proved an elusive goal...Three shots of the vaccine, known as RTS, S or Mosquirix and produced by GlaxoSmithKline, gave babies fewer than 12 weeks old 31 percent protection against detectable malaria and 37 percent protection against severe malaria, according to an announcement by the company at a vaccines conference in Cape Town.
Italian police detain 9 cardiology doctors, accused of experimenting on patients
The Windsor Star
The investigation began over a year ago after consumer groups raised alarm about some suspicious deaths at the Polyclinic hospital in the northern city of Modena.
How to strengthen health research capacity in Africa, by researchers
The Guardian Nigeria
DETERMINED to identify solutions to key national health problems, Nigerian researchers have given a blueprint on how to strengthen health research capacity in Africa.
The Impact of Sequestration on NIH
Conclusion: America should be investing more in medical research, not less. Report details the reasoning.
HPV vaccine may benefit HIV-infected women
NIH News
Women with HIV may benefit from a vaccine for human papillomavirus (HPV), despite having already been exposed to HPV, a study finds. Although many may have been exposed to less serious forms of HPV, more than 45 percent of sexually active young women who have acquired HIV appear never to have been exposed to the most common high-risk forms of HPV, according to the study from a National Institutes of Health research network
MRI and EEG could identify children at risk for epilepsy after febrile seizures
NIH News
Seizures during childhood fever are usually benign, but when prolonged, they can foreshadow an increased risk of epilepsy later in life. Now a study funded by the National Institutes of Health suggests that brain imaging and recordings of brain activity could help identify the children at highest risk. The study reveals that within days of a prolonged fever-related seizure, some children have signs of acute brain injury, abnormal brain anatomy, altered brain activity, or a combination.
Two NIH landmark studies show power of epidemiology research; underscore need to address health disparities
NIH News
From the article:
Researchers from the NIH-supported Reasons for Geographic and Racial Differences in Stroke (REGARDS) study found that black men and women were about twice as likely to die from coronary heart disease (CHD) compared with their age-matched white counterparts. Black women had a higher incidence of fatal and nonfatal coronary disease than white women. The findings are based on an analysis of 24,443 men and women.
Rethinking Reading: UI study breaks new ground in reading development research
Iowa Now
From the article: We were interested in not just whether they could do exactly what we were teaching, but whether they could learn something more robust that would enable them to apply what they had learned to new tasks and new words.
September, 2012
Genes Now Tell Doctors Secrets They Can't Utter
New York Times
Cancer Study Points to Tighter Pairing of Drugs and Patients
New York Times
Making Choices: How Your Brain Decides
Research from the University of Iowa
Can in-vehicle technologies help improve driver safety for seniors?
Iowa Now
July, 2012
U.S. Medical Research Endangered
- The Baltimore Sun
The Future of Human Subjects Research Regulation
- Harvard Law Today
10 Years after Hormone Therapy Study: What Doctors Know Now
- USA Today
In Treatment for Leukemia, Glimpses of the Future
- The New York Times
June, 2012
Review Boards Force Sex Research into the Closet, Survey Suggests
- The Chronicle of Higher Education
August, 2011
June, 2011
When the Research Subject is You
-Consumer Reports Magazine
May, 2011
Breast Cancer Gene Discovery 'Like Finding Gold'
- The Telegraph
Secret Archive of Ulster Troubles Faces Subpoena
- New York Times
April, 2011
March, 2011
Company Pays Government to Challenge Pesticide Research Linked to Parkinson's
- Politics Daily
Experts Call for Stricter Regulations in Clinical Trials of New Drugs
- Pittsburgh Post Gazette
Experts Call for Stricter Regulations in Clinical Trials of New Drugs
- Pittsburgh Post Gazette
February, 2011
Risk and Reward in Utero
- New York Times
Will a Cancer Spread? Question is a Crucial One
- Boston Globe
Returning the Blessings of an Immortal Life
- New York Times
They Entered My Home Without My Consent
- Ampersand
Health Care Economics Research at NIH
- Research! America
Bayer Admits It Paid "Millions" in HIV Infection Cases - Just Not in English
FDA Says Drug Firms Didn't Finish Follow-Ups
- Wall Street Journal
January, 2011
Deadly Medicine
- Vanity Fair
Gulf Grows Between Research Practice and Participant Preferences in Genetic Studies
- red Orbit
November, 2010
Retractions in the scientific literature: do authors deliberately commit research fraud?
- Journal of Medical Ethics
Pres. Obama Orders Investigation of Guatamalan Syphilis Experiment
- Alliance for Human Research Protection
Drug Maker Hired Writing Company for Doctors' Book
-NY Times.com
A Small Step Back for MannKind?
- Seeking Alpha
October, 2010
U.S. Apologizes for Guatemala STD Experiments
- msnbc.com
September, 2010
Judge Refuses to Stay Stem-Cell Ruling
- Wall Street Journal
Will Aging Chimps Get to Retire, or Face Medical Research?
- NYTimes.com
August, 2010
Feds admit storing checkpoint body scan images
- CNET News
What to Tell the Patients After a Trial Goes Awry
- NYTimes.com
July, 2010
Don't Mess With the DSMB
- The New England Journal of Medicine
June, 2010
"But the data is already public": on the ethics of research in Facebook
- Ethics and Information Technology


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4038 Irvington Ave
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Used 2005 COUGAR 301
Overall Length: 32' 9" Width: 8' Height: 11' Stk No: 41318
Weight (UVW): 7380 # Maximum Additional Cargo Capacity: 2300 #
Water Capacities; Fresh: 45 G Black: 30 G Grey: 30 G Int Color: Burgundy
Included Options: Quad Bunks, Air Conditioner, Awning, TV Antenna, Stabilizing Jacks, Rear Pull-out Bike Rack, Outside Shower, Enclosed Underbelly, "POLAR PKG" Insulation, Microwave, Range Cover, Sink Covers, Jackknife Sofa, 3 Burner Range w/Oven, Double Dr Refrigerator, 6G DSI Water Heater, Day/Night Window Shades, AM/FM/CD Stereo, TV, Shower Surround, Equalizing Hitch & Sway ($550 Value)
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Overall Length: ~30' Width: 8' Height: 11' 6" Stk No: 41266
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Included Options: GEL Fiberglass Exterior, Front Power Jacks, Rear Stabilizers, Roof Ladder, Microwave, 10G DSI Water Heater, Outside Shower, Sewer Flusher, Awning, AC, Spare, Sofa-Hide-A-Bed, Day/Night Window Shades, Tub/Shower Surround, Skylight in Shower, TV Anten na, 2 TVs, AM/FM/CD/DVD Player w/Surround Sound, Exterior LP port, Al Wheels, Lend-A-Hand, Leather Swivel-Rocker-Recliner, Ceiling Fan Lg Dbl Dr Refrigerator, Sink& Range Covers, Folding Shower Door, & MORE!
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Heard of the "War on Drugs"?
It refers to governmental programs intended to suppress the consumption of certain recreational drugs. First used by US President, Richard Nixon, in 1972 to describe US's programs, equivalent terms are now used in many countries.
The War on Drugs utilizes several techniques to achieve its goal of eliminating recreational drug use:
specialized law enforcement agencies, officers and techniques
information campaigns to educate the public on the dangers of recreational drug use
critics often cite these campaigns as a primary reason to end the War on Drugs; they claim the campaigns are frequently misleading or outright lying
streamlined enforcement and evidence-gathering procedures
Marijuana is a drug included in the "war". Drugs deemed socially, religiously, medically or politically unfit for recreational use are frequently banned. The legal position of marijuana alters throughout the world, reflecting how Governments wage their "war". From a blanket prohibition suppressing all use, to permitting certain amounts for personal use, the legalization of marijuana fights different fights in different countries. However arguments FOR and AGAINST the legalization of marijuana remain the same.
The Roots of Marijuana Law in the US
The Marijuana Tax Act was introduced in 1937. It required sellers to obtain a license. Blanket prohibition was not the intention. Harry Anslinger (Bureau of Narcotics Commissioner) testified in hearings on the subject that the hemp plant needed to be banned because it had a violent "effect on the degenerate races." This specifically referred to Mexican immigrants who had entered the country, seeking jobs during the Great Depression.
The law passed quickly and with little debate. The American Medical Association (AMA) protested the law soon after, both on the grounds of actual disagreement with the law and the supporter's lies on the subject, claiming the AMA had vocalized support when, in fact, the opposite was true.
There was some legal wrangling over the issue after it was passed. The people who were allowed to issue the licenses did not do so, effectively banning the drugs. The judicial system did not accept, at first, that being arrested in possession of drugs was a tax violation because it must have come from an unlicensed source (because there were no licenses), thereby avoiding taxes. Thus, the federal government did have the right to regulate the ingestion of drugs.
Prohibition must be weighed against the loss of personal freedom. Countries have a responsibility to respect individual free will and the right of self-determination.
The immorality of marijuana use can only be based on one set of moral beliefs. For example, it is discriminatory to claim that Judeo-Christian abstinence from intoxication is the correct set of moral beliefs.
The War on Drugs serves the immediate interests of politicians. By taking a "moral" stand against recreational drugs, or fighting the evils caused by the illegal drug trade they increase their popularity amongst constituents.
Legal prohibition does not stop consumers from consuming drugs, it does not stop trafficants from producing and selling it. The price of the final product increases to abnormally high values because of the black market status, which together with the powerful effects of drug addiction causes users to commit crimes in order to fund their addiction.
Critics of the War on Drugs advocate the partial or complete decriminalization of illegal drugs, combined with a system of regulation, as happens with alcohol and prescription drugs. By providing legal supplies of currently illegal drugs the price will fall, leading to a collapse in the illegal drug industry, and a reduction in crimes committed by both drug suppliers and users. They also argue that the reduction in the price will lead to little, if any, growth in drug addiction, due to the inelasticity of demand. Some even state that in a strictly regulated market, drug use may fall overall, by removing the marketing activities of the illegal drug industry.
It is not worthwhile for a law to forbid people from willingly exposing their own bodies to harm by using drugs, any more than by overeating or bungee-jumping. Obesity is a national epidemic, killing millions every year, but the government has no right to regulate how much citizens eat.
Drug users exercise free will when they chose to use drugs; a person has the right to give up his or her own freedom. A Government does not have the right to dictate them. No drug eliminates free will. It is possible to quit using any drug. Many banned drugs are significantly less deleterious to free will than legal alcohol or tobacco. Severe physiological addiction has been demonstrated for tobacco (stronger than cocaine), but no strong physiological addiction has been shown for marijuana.
Legalize marijuana and reduce health care costs by reducing the probability of overdoses and accidental ingestion of an unintended drug through standardization of drug purity by state-sponsored production and sale.
There is no clear and obvious third party harm. Such examples are caused by related activities that can be illegal without blanket prohibition. For example, driving while intoxicated is illegal, while drinking alcohol without driving is not.
Harm caused to children by their parents' excessive drug use is criminal insofar as it constitutes child neglect; drug-specific laws are unneeded.
If drugs were legalized, the companies that manufacture and market them would be sued, such as cigarette companies have been exposed to lawsuits. Legalization of drugs would work to increase liability on producers forcing health standards.
Legalization would allow greater regulation. Cigarettes come with warnings. Alcoholic beverages are clearly marked with the amount of alcohol. Currently legal drugs contain a listing of all active and inactive ingredients. Illegal drugs could be sold legally with ingredients lists, warnings and purity levels clearly marked.
Recreational drug has no clear and obvious harmful effect on anyone besides the user (who chooses to accept those risks). The War on Drugs, on the other hand, places non-users' friends and loved ones in jail. The War on Drugs does have clear and obvious harmful effects on third parties.
Countries who have experimented with legalization have had positive results.
A State cannot be involved with the distribution of substances considered immoral by relevant lots of the population. A substance considered unhealthy cannot be produced and distributed with the help of the state, because the goal of the state is to protect citizens' health and not to expose them to risk.
The easy availability of drugs would create new consumers rather than rescuing current ones.
Drugs are addictive. They rob the user of free will. A drug user cannot make an informed and rational decision to continue using drugs because the use of the drug eliminates that user's ability to think logically. Nor can they disseminate themselves from drug taking.
Drug use is dangerous to persons besides the user, in the rise of health care costs, violence associated with the use of drugs, neglect of children by drug-addicted parents, and other third party effects.
The use of soft drugs, such as marijuana, leads to the use of hard drugs (the Gateway Theory).
Drug dealers will sell to anyone, including children. Merchants who legally sell alcohol and tobacco are not allowed to sell to children. Many high school students report that it is easier to obtain illegal drugs than alcohol and tobacco.
Legalizing drugs will send a message to children that drug use is acceptable.
Cool Sites:
Legalize Cannabis - Sites for and against marijuana.
Medical Marijuana - Find out the truth about medical marijuana at Medical Marijuana Blog.
Vaporizer – Premium herbal vaporizers at very low prices.
Hydroponic Marijuana – Grow unbelievable buds, which means you need to smoke less for a sensational stoned feeling.
Marijuana Prices – Fascinating site that reveals marijuana prices and which states have the highest rates of marijuana use in the USA.
Marijuana Tea – A great way to consume your greens in a lovely drink.
Bongs and Pipes – The world's finest, high quality smoking paraphernalia.
63 Responses to ARGUMENTS FOR AND AGAINST THE LEGALIZATION OF MARIJUANA
Wow, Chris, way to go!! I just spent the whole semester doing research on medical marijuana. I am on the legalization waltz. I'm from Texas, I'm hoping that in 2015 we can see progress in the works. Did you know that the U.S. government patented cannabinoids? In 1994, we found cannabinoid receptors in our brains. It is patent number 6630507. Ain't that crazy? How can you patent something you say doesn't exist? Just in case, tho, they patented cannabinoids for use in the neuro pathways in our brains. How do they tell all the children with epilepsy that certain states have certain rights. That's B.S. Once California legalized medical marijuana, all 50 states should have followed suit. Maybe with a united front, we could get this classification changed. In all actuality, it is still against the federal law. So Obama's troops swoop in and start closing dispensaries. This is causing much havoc in the lives of the people that own those stores, and all the way down the line for their employees. Way to go, so much for stimulating the economy. It was a pleasure to chat with someone that clearly did his homework.
It's hard to find any argument on the internet that isn't one-sided. People don't want to debate, they want to shove what they think down everyone else's throat. To be honest, there aren't enough arguments for marijuana here and the arguments against it aren't even debunked. You just stated them and left it at that. The truth is that hemp, or marijuana is not only a safe drug with very few negative effects in adult users, it is also a drug that has been used for thousands of years in both medicinal and industrial settings. (btw, marijuana kills cancer cells and can be used in other methods that don't require smoking) The constitution was written on hemp paper just as all paper at the time. It grows easier, faster, and with more yield than wood and cotton. Any other alternative that we use today when it comes to textiles, energy, paper and construction are inferior to hemp. There are literally countless uses of hemp, from dynamite created from the cellulose compound, to clean renewable energy that could make the US energy independent from the rest of the world. People like George Washington saw the extremely helpful nature of this plant, declaring that it should be sowed "everywhere." That was hundreds of years ago. We have only discovered more and more uses of hemp as time rolls on. People like Henry Ford can be credited for such discoveries as a composite plastic made with hemp that is both 10 times stronger than steel and only weighing 2/3 as much. He even used it as bio fuel in his original Model T prototype AKA the hemp car. Medicinal uses are also being found as time passes, with many breakthroughs in this field showing that medical marijuana is more effective than pharmaceuticals in patients with PTSD, epilepsy and seizures, glaucoma, chronic headaches, eating disorders, and cancer. The list can go on all day if you want it to. Not only has it been found to be more effective, it also has side effects that pale in comparison to pharmaceuticals that treat the same illnesses. Our president has said that marijuana is no more harmful than alcohol, yet leaves it on the Schedule 1 list, declaring it more powerful than cocaine and meth, which are both widely-known as much harder drugs than marijuana. It also says that there is no accepted medical benefit and that the drugs in Schedule 1 have great potential for physical dependence. Marijuana withdrawals are are as petty as caffeine and are much rarer. This man says he supports it, yet medical marijuana dispensaries are being raided on his watch, forcing these patients to buy their medicine on the street with no assurance that they are getting what they pay for. This, in turn, only gives the cartels more power. When people argue and say that marijuana is a "gateway" drug, they are admitting that there are so few truthful arguments against marijuana, that they need to bring in other drugs that are easier to argue about, saying "This gets you higher though! So that means that after awhile you'll get bored and want some variety!" In truth though, the high people get from marijuana is not even similar to what other drugs offer. Honestly you can't even compare them besides the negative side effects that come with. The gateway drug theory is the last resort in the war on freedom and has been shown from multiple polls and statistics to be false. To make marijuana legal does not condone that teenagers use it. Just with alcohol, they would have to be 21 to use it legally. Even if kids started smoking pot instead of drinking alcohol regardless of this fact, they would be better off. In order to overdose on pot, you would have to smoke, according to theory, 1,500 pounds in 15 minutes. It is not linked to violent behavior like alcohol and it is less dangerous when idiots decide to drive stoned than intoxicated, by at least 500%. Even if the person does get in a wreck, it's extremely unlikely they were going 120 mph like what a drunk driver might be going. Alcohol has become highly welcomed in American society through countless ad campaigns which group alcohol with your favorite sport. This is not the example we should give our kids, not at all. If we want them to know how dangerous alcohol is, we need to be less liberal with these commercials making beer look like the biggest joyride of your life. We also need to realize that 750,000 people are incarcerated every year in the US for marijuana related crimes, 82% of which for simple possession. We have the highest incarceration rate in the world because of prohibition, which not only shows how lacking we are on our core value of "freedom" but also speaks volumes when you compare people who have smoked and gotten caught and people who have not. If our president got caught for smoking marijuana in college, his life would not even resemble what it is now. He would have been convicted of a crime that can have longer sentences than rape and murder, even though it is a victim less crime. He would be labeled an ex-con for the rest of his life, being refused basic American freedoms like the right to vote to this day. He would not even be able to get a minimum wage job because he would be seen as a blight on society. That's our president. A war on drugs is a war on the people. Stop telling us how to live our lives. Empty the prisons and focus on things that matter. Make our society safer and stop making our protectors our enemies. Black people make up 13% of society and 14% of drug users, yet 56% of drug related arrests are on black people, even though they use drugs like marijuana about as much as white and Hispanic people. It is blatant profiling sanctioned by law enforcement.
I just want to know where the persons constitutional rights are of those who are highly allergic to the smoke, the plant, and proteins. People are there are no health problems, I believe this is a one sided argument. I have on several occasions been rushed to ER just because the idiot next to me rolled down his window at a stop light and the smoke bellowed into my car. It closes my airways and stops my heart. If this is legalized and allowed in public places I would not have anywhere to live. And I do not think that it would be freedom to have to lock my self up just so others can get high.
Tricia says:
"I have on several occasions been rushed to ER just because the idiot next to me rolled down his window at a stop light and the smoke bellowed into my car. It closes my airways and stops my heart."
Smoke and (before and during) drive won't be legalized, just like the current law prohibits drink and drive, and intoxicated in anyway.
This is not a mater of constitutional rights. There are many people that I know who are allergic to tobacco smoke and they have this same problem. The only difference is that tobacco is already legal and my friends avoid all contact with people who smoke. There are ways to get around and ways to protect yourself in high density areas where people do smoke. If it is legalized and it has a huge chance that it will then you will either have to move somewhere where they are more conservative or find a way to deal with society as it evolves.
My fellow Americans let's get our act together and set our priorities right! Legalizing marijuana is a bad idea. It negatively affects our work force productivity, increases addiction and the spiraling, out of control problems that causes, and who knows the long term health affects more of this use will cause? What young person wants to risk having a possible early lung disease like the onset of bullous emphysema?? Health care costs will rise and everyone will be up in arms about it! We've already seen this with cigarette and alcohol's affect on the health of Americans, why add fuel to the fire?
Suzieq says:
"It negatively affects our work force productivity, increases addiction and the spiraling, out of control problems that causes, and who knows the long term health affects more of this use will cause?"
Same as alcohol, and the negative effect of alcohol to one's health is even greater.
Have you seen any of your co-worker shown up at work drunk? If he or she does it, they'll get fired.
Most people don't do it because of the consequences.
How will the marijuana make any difference?
Marijuana should be legalized. These cons mentioned are not even helping to support the argument to not legalize marijuana. Alcohol and tobacco are substantially more addictive than marijuana. Nicotine is just as addictive (if not more) than heroin! Yet, nicotine and alcohol products can be bought in any gas station and convenient store in the U.S.! No one has died from smoking too much weed. It's impossible, you would have to smoke an obscene amount and by then you would probably pass out. It's all about your decision making. You choose to smoke, be inquisitive about the world, and make wise decisions regarding your safety then you do so. But if you engage in risky behavior that's your fault and not the drug. Besides, drivers cannot blame the alcohol for getting charged with a DUI; they blame themselves for making a bad decision. It's your choice to get into a car high or drunk. Alcohol and tobacco are a lot worse for you than weed and the statistics prove this; the government just needs to legalize marijuana.
Obama even admitted that marijuana was a lot less harmful than alcohol! The government must get past its insecurities about pot.


text:
February 2012
Trade Paperback · 128 Pages
Nick Hern Books
Trade Paperback · 128 Pages
Nick Hern Books
Recommended for These Courses
Jean works in a garage and consoles herself with alchol and perfunctory sex. Jean's insistent neighbor, Dawn, and Dawn's Irish laborer husband Mick, and Mick's spineless friend, Len, all join her in a funny, drunken, sad celebration of their mutual affection and bleak lives.
About the Author
MIKE LEIGH was born in 1943 in Salford, Lancs. He studied at RADA and the London Film School. He is best known for Nuts in May and Abigail's Party on TV and the films Naked, Life is Sweet, Secrets and Lies and Vera Drake. His most recent film, Another Year, opened to huge critical and audience acclaim at the 2010 Cannes Film Festival. He currently lives in Muswell Hill, North London.
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Top Dividend Funds Trounce S&P 500
NEW YORK ( TheStreet) -- By some measures, the credit crisis led to the worst period ever for stock dividends.
In 2008 and last year, a record number of companies cut or eliminated dividends, according to Standard & Poor's. As a result, investors dumped shares of longtime dividend payers such as General Electric (GE) and Pfizer (PFE).
Despite the upheaval, some dividend funds have excelled. Investing exclusively in dividend stocks, Frost Dividend Value (FADVX) returned 7.2% annually during the past five years, surpassing 99% of its large-value peers and outpacing the S&P 500 by 6 percentage points, according to Morningstar. Other funds that finished in the top 10% of the category include BlackRock Equity Dividend (MDDVX), Columbia Dividend Income (LBSAX) and RiverSource Dividend Opportunity (INUTX).
How did the funds succeed at a time when dividend stocks were collapsing? Instead of just buying the highest-yielding stocks, the winning managers focused on rock-solid companies that had the potential to increase dividends. The approach led the funds to steer clear from troubled financials and other shaky stocks during the market downturn.The dividend strategy has long been supported by academic research. Studies have shown that while dividend stocks outperform non-dividend payers over long periods, not all dividend stocks generate similar returns. In a 2006 study by Credit Suisse, researchers divided stocks into 10 groups based on dividend yields. Stocks in the 10th decile -- the highest-yielding group -- returned more than those in the 1st decile, which paid little or no dividends. But stocks in the 8th decile recorded the greatest total returns. The relatively weak performance of the top decile stocks is no accident, says Dick Dahlberg, manager of Columbia Dividend Income. When stock prices fall, dividend yields rise. So many high-dividend companies are battered businesses. Companies in the top 12% of the dividend payers underperformed the market, and many high-yielding stocks eventually cut their dividends. "You get the best long-term performance from stocks that have growing dividends and yield only a bit more than the market average," Dahlberg says.
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Submit your question below about any cosmetic procedure to be considered for posting with an answer from one of our board-certified plastic surgeons.
If your question is about the cost of a procedure, click here. For referral to a qualified surgeon in your area, see find a surgeon.
Note: ASAPS cannot give advice about specific medical problems nor should answers provided by responding surgeons be substituted for a complete medical history, work-up and an in-personal medical/surgical consultation. Sorry we can't answer all questions. We try to select questions that have the widest general interest.
Can I have nipple surgery under local anesthesia while pregnant?
I had an implant exchange from saline 375cc to mentor 450cc w nipple repositioning July 25 2013 (special sutures to prevent nipples from stretching back out was placed). My nipples are still uneven and my breasts are fuller in upper pole vs tear drop shape I expected. 1 week post surgery I found out I was pregnant and I want the nipples redone now! Can I do this under local anesthesia while pregnant? Will my nipples stretch out again due to pregnancy? How can I achieve tear drop shape?
You really answered your own question by wondering if you will have some change during pregnancy. The answer is that most likely you will have a change in your breasts with pregnancy with or without breast feeding so the proper course of action is to wait. I would say wait at least 3 months after cessation of breast feeding before having any revision surgery.
I hope this helps
Dr. Edwards
Thank you for your question. You should delay your surgery until after your pregnancy primarily because pregnancy will certainly alter the shape of your breasts, nipples and areolae.
In addition most plastic surgeons recommend against having any elective surgery procedure including the use of local anesthesia during pregnancy, to protect the developing fetus.


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Dec. 12 (Bloomberg) -- Copper declined on speculation that a slowdown in China's industrial output will increase stockpiles in the biggest consumer and on concern that Europe's debt crisis will persist even after leaders agreed to a fiscal accord.
The three-month contract on the London Metal Exchange fell as much as 2 percent to $7,657 a metric ton and traded at $7,658 by 4:51 p.m. Tokyo time. The metal lost 1 percent last week. The March-delivery contract dropped 2.4 percent to $3.471 per pound on the Comex in New York.
China's industrial production grew 12.4 percent in November from a year earlier, the slowest pace since August 2009. Copper stockpiles jumped 26 percent last week to 72,712 tons from a 28- month low of 57,655 tons a week earlier, data from the Shanghai Futures Exchange showed Dec. 9.
"Copper was undermined by stockpiles in Shanghai that increased sharply last week," said Hwang Il Doo, a senior trader at Korea Exchange Bank Futures Co. Prices will also be influenced by developments in Europe, he said.
German Finance Minister Wolfgang Schaeuble said euro-area policy makers will now focus on implementing the 200 billion euros ($267 billion) pact to strengthen budget rules as quickly as possible. The euro fell 0.6 percent against the dollar before a German report tomorrow that economists say will show investor confidence in the region's largest economy slid to a three-year low.
The decline in copper prices may be capped by a strike at Freeport-McMoRan Copper & Gold Inc.'s Grasberg mine in Indonesia, Hwang said.
Grasberg Strike
Workers at Freeport-McMoRan's Grasberg mine will extend their strike for a fourth month until Jan. 15, a union official said Dec. 10. The workers informed the Papua province manpower authorities and the company's management about their decision on Dec. 5, according to PT Freeport Indonesia's labor union spokesman Juli Parorrongan.
Copper for February delivery on the Shanghai exchange retreated 0.5 percent to close at 56,760 yuan ($8,923) a ton. Copper imports by China rose to the highest level in 20 months in November. Inbound shipments of the metal, copper alloy and products gained 18 percent to 452,022 tons from 383,507 tons in October, according to Bloomberg calculations based on data posted on the website of the General Administration of Customs.
Aluminum lost 1 percent to $2,044.75 per ton in London and zinc fell 1.4 percent to $1,974.75 per ton. Nickel dropped 2 percent to $18,225 per ton and lead declined 2.1 percent to $2,120 per ton, while tin fell 2.7 percent to $19,710 a ton.
--Editors: Thomas Kutty Abraham, James Poole
To contact the reporter on this story: Jae Hur in Tokyo at email@example.com
To contact the editor responsible for this story: Richard Dobson at firstname.lastname@example.com


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The Ultimate Party Experience
At Peter Piper Pizza it's party time all the time! Whether you're celebrating a birthday, a big win, or just because, we'll help you build the ultimate party experience. We combine quality pizzas on made-from-scratch dough, the industry's hottest games, and a dedicated host to make your party an event to remember.
We offer a variety of packages, add-ons, and pricing options to meet your unique needs. So what are you waiting for? Get started right away by booking your party online, or by contacting your preferred Peter Piper Pizza today!
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127 E. Williams Field Rd.
Gilbert, AZ 85295
Sun-Thu 11am-10pm Fri 11am-11pm Sat 10am-11pm


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Mon-Fri: 7am-1am EST / Sat-Sun: 7am-11pm EST
If you placed an order on ApplianceHelp.com the order is still valid and you can check on its status and make changes here on PartSelect.com. Click here for more details.
ApplianceFrigidaire Refrigerator
Level of DifficultyReally easy
Time to do repairLess than 15 mins
Age of Appliance5 - 10 years
2 out of 4 people found this instruction helpful
Unplug fridge, tilt back against wall to provice clearance to install new assembly. Used self starting screws to install. Used cordless drill with nutdriver to install assembly.Time to complete job-5 minutes
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Social Scapegoat is a media hub for disgruntled malcontents, aspiring journalists, the voiceless, impoverished, ungrateful, and ignored. We slash, crash and burn social standards, stigmas and sacred cows (or, goats â as the case may be) and give the triumphant finger to the dawning era of political correctness. We mock politicians, make fun of the news, and attempt to bring a fraction of sanity and reason to the bamboozling political landscape. (We also occasionally make fun of celebrities). *Social Scapegoat is a (proudly) independent political commentary blog. It does not reflect the views of any organisation we work for, have worked for, or may work for in the future.


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2008 Jeep Grand Cherokee Laredo V6 from North America
I wouldn't buy another, based on the valve stem breakage alone
I have replaced the TPMS (Tire Pressure Monitoring System) Valve stems 6 times.. they are brittle at the threads and break when inflating the tire. Most recently the stem broke while my wife was removing the plastic cap. Cheapest price I have got to replace is 98 dollars.
Checking Jeep forums, this tends to be a problem dating all the way back to 2005 model Cherokees, and also on the Commanders.
At 39,000 miles, I noticed fluid under the vehicle. Upon inspection, the bolts on the transmission pan had loosened, pretty easy fix with a torque wrench, however afterwards I attempted to check the transmission fluid to see how much was lost... only to find a cap on the dipstick tube that read "dealer use only". There isn't a dipstick, so I took the Jeep to the dealer, and forked over 35 dollars for them to check and fill the transmission fluid.
General Comments:
The Jeep rides nice, and overall it has nice features, power seats etc, it's roomy, has plenty of power... nice stereo system, it's quiet.
However, forking over 98 dollars every few months to replace the TPMS valve stems is old to me, and to add to the problem they leak air where bolted through the rim, so I constantly get the low tire pressure warning light.. and have to put air in the tires, increasing the chance to break them.
Would you buy another car from this manufacturer? Don't Know
Review Date: 27th January, 2010
19th Jun 2012, 16:09
You can have a tire shop install the sensor using TMPS straps on the inside of the wheel to avoid this mess. They just use regular stems, and the system still functions, because the TMPS is still inside the inflated tire.
You can also do what I did, and put them in a PVC container with a hole drilled in it. Install a standard valve stem and seal them inside. Inflate to 33 PSI, throw it in the trunk and profit. Cost was $12.
25th Jul 2013, 04:45
Please explain exactly what you've done with the tire sensors? I have a 2008 GC diesel, and twice a year when I change to my winter tires, the sensor lights are lit up for the whole winter season. I didn't want to spend the $80.00 per tire that the garage told me it would cost.


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17 results for "mike grimala"
All-State soccer: Oliver, Rios among top starsMike Grimala
ESPNHS has unveiled its Indiana All-State soccer team. Southport's Andrew Oliver and Lake Central's Manny Rios are two of the most accomplished players on the list, which can be found below. Indiana All-State Soccer Starting 11 [F] Dominique...Blog | September 27, 2011
All-State soccer: White, Fagundez among top starsMike Grimala
ESPNHS has unveiled its Massachusetts All-State soccer team. Nobles' Oliver White and Leominster's Diego Fagundez are two of the most accomplished players on the list, which can be found below. Massachusestts All-State Soccer Starting 11 [F] ...Blog | September 27, 2011
All-State soccer: Zamora, Oliver among top starsMike Grimala
ESPNHS has unveiled its Illinois All-State soccer team. Crystal Lake South's Charlie Oliver and Boylan's Victor Zamora are two of the most accomplished players on the list, which can be found below. Illinois All-State Soccer Starting 11 [F] J...Blog | September 27, 2011
All-State soccer: Zurita, Taintor lead the wayMike Grimala
ESPNHS has revealed its Connecticut All-State soccer team. Bunnell's Zach Zurita and E.O. Smith's Mitchell Taintor are two of the most accomplished players on the list, which you can find below. STARTING 11 Pos, Name, School, Club [F] Matt Bar...Blog | September 27, 2011
ESPNBoston unveils soccer rankingsMike Grimala
ESPNBoston has released its first soccer rankings of the 2011 season, and there wasn't much of a surprise at the top. Ludlow, winner of two of the last three Division 1 state championships, opens the campaign at No. 1. The top-ranked Eastern Mass ...Blog | September 14, 2011
Got Game: Evan TrychtaMike Grimala
Player: Evan Trychta School: Naperville North Sport: Soccer The Word: Naperville North soccer is currently ranked No. 2 in the state (and No. 20 nationally in the POWERADE FAB 50), and now that Trychta seems fully recovered from a foot injury suff...Blog | September 08, 2011
Got Game: Thomas SannerMike Grimala
Player: Thomas Sanner School: North Central Sport: Soccer The Word: North Central has looked impressive so far, running out to a 7-0 start and a No. 1 state ranking in most publications (No. 11 nationally in the POWERADE FAB 50). Sanner is a big r...Blog | September 08, 2011
Zurita, Bunnell eyeing state soccer titleMike Grimala
Bunnell soccer came close last year. So close. But after being upset by New Canaan in the Class L championship game, the Bulldogs are starting all over again at the beginning. Luckily, they have a player like Zach Zurita to build around. The senio...Blog | September 07, 2011
Got Game: Tucker HackettMike Grimala
Player: Tucker Hackett School: Daniel Hand Sport: Soccer The Word: Hackett earned just about every honor he could last year - the goalkeeper was an All-Conference selection, an NSCAA/adidas All-American and a Class L All-State pick as a junior. He...Blog | August 30, 2011
Early look at top soccer playersMike Grimala
ESPNHS soccer expert Sheldon Shealer spent the summer compiling information on the best soccer players in the country, and he has posted his early list of Indiana's best senior prospects. Southport's Andrew Oliver and North Central's Thomas Sanner he...Blog | August 23, 2011
Leominster phenom starring for RevsMike Grimala
Diego Fagundez is mostly a normal 16-year-old kid, but as Scott Barboza points out in this ESPNBoston piece, he also happens to be a professional soccer player. "By all appearances, Fagundez is a regular teen. He sports a Mohawk that makes his 5-fo...Blog | August 22, 2011
Fort Zumwalt West senior Drake Houdashelt won't blow anyone away ...Mike Grimala
Fort Zumwalt West senior Drake Houdashelt won't blow anyone away with his wrestling technique, but his unique style has propelled him into the nation's elite all the same.Story | Conversation | December 22, 2009
High school athletes and teams across the country do what they ca...Mike Grimala
High school athletes and teams across the country do what they can to support Breast Cancer Awareness MonthStory | Conversation | October 20, 2009
Rachel Williams has all-around game, but her awe-inspiring aerial...Mike Grimala
Rachel Williams' all-around game does Archbishop Mitty (San Jose, Calif.) volleyball proud, but it's her pop that makes a lasting impressionStory | Conversation | October 01, 2009
Video is where it's at for BeardMike Grimala
Each weekday, ESPN RISE brings you five vital stats from athletes across the country. On Monday, we catch up with Josh Beard.Story | Conversation | October 20, 2008
Beard is Mr. Do Everything for SchaumburgMike Grimala
Schaumburg will rely on senior Josh Beard for scoring, defense and leadership this season, but the do-it-all star is used to the role by nowStory | Conversation | September 17, 2008


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Baggallini Zipper Bagg Tomato w/Mango Interior Women's Handbag - Order. Beauty. And the freedom that comes from knowing everything is in its place. With these guiding principles two female flight attendants began Baggallini. A perfect blend of thoughtful function and style, Baggallini has grown from two world travelers into a worldwide leader in incredibly organized bags and accessories that look as good as they perform. Instantly desirable by women who crave a well ordered life, the freedom it enables, and the beauty it creates.
Baggallini Zipper Bagg Tomato/Mango Women's Handbag
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"I love Footwear etc. xoxoxox. They have excellent customer service, great value for the money, the largest selection of quality brands. No one can compete with this company, they are the best in every way, they make it so easy to buy shoes."
©2014 Footwear Etc. All Rights Reserved. For any questions or assistance call 1-800-720-0572.


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Most Xbox gamers are aware about Microsoft's Games With Gold (GWG) initiative, it is a monthly program where both the Xbox One and Xbox 360 owners are delighted with two free games for a limited time. GWG has been criticized for past few months for not offering any solid titles compared to its competition PSN+, however things are changing and ... Read More »
Tag Archives: Dishonored
Dishonored and Mainstream: of award shows and Triple-A games
I love everything about music, movies and videogames, videogames especially, be it for my private retribution on the absurd reality around or for the pure enjoyment out of it. As of now, when friends or people approach me cautiously, asking me what to harpoon from the latest video game releases, I do not stand with the obvious answer. Of course ... Read More »
Pushing the Limits
There was a point during the Hong Kong section of the original Deus Ex when I came across a rare moment of brilliance I hadn't experienced before in a game. In the apartment where I was supposed to break-in and investigate without detection, I had been discovered. With nowhere to hide, I made a go for the window. Jumping through ... Read More »
Reality or Illusion: Emergent–True Form of Narration in Games
[An exploration of the popular opinion of an issue — long-time or currently trending that examines it from various angles to determine exactly how much truth there is in it. By removing the layers of superficiality and bias and examining it from different perspectives, this feature aims at determining what exactly is the "Truth" and what is "Illusion] Video-games have often been ... Read More »


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Hotel Clara Luna
2 kids from 0 to 10 years old stay free sharing room with their parents
FREE WIFI + AMERICAN Breakfas FOR 2t!
In the year 2003 Mister Carlos Ferrez Matos, a visionary businessman, had the idea to enrich the tourist activity of our capital with the construction of a hotel inside the installations of the building Aries, located at Manuel vila Camacho Avenue 42 in the center of the city of Xalapa, Veracruz-Mexico. Nevertheless, for different reasons the works were suspended.
As homage to one of the pillars of the progress of Xalapa, two years ago the project was taken up again with the original thought that Mr. Carlos had, to give a good service and attention to the visitors of our beloved Athens of Veracruz.
Clara Luna Hotel takes the beauty of the gold time in Mexico, inspired by the compositions of Agustn Lara, recognized composer and veracruzano singer, with a minimalist and sustained architectonic style with a great team of collaborator who at any moment strives to offer an unforgettable experience to our clients.
Clara Luna Hotel will give you the best experience in hosting in Xalapa, Veracruz.
We have 19 completely carpeted rooms: 14 Double rooms with 2 Twin Beds, 4 Simple rooms with 1 King Size Bed and 1 Suite Room with 1 King Size Bed
All Rooms are equipped with one king or two double beds, direct telephone with free local calls, free wifi access, cable tv, elegant ceiling light fan, hairdryer, room service, bathroom amenities, shower only, windows opens, air conditioned, wake up service.
Azul Caf Restaurant is a new concept in the service of foods that takes as main influence to the Mexican gastronomy, complementing its exquisite letter with subjects of gossip of Mediterranean origin, with the purpose of to please to all the palates and to obtain that its visit, becomes a true memory in its palate. Open Monday to Friday from 7 am to 11 pm, Saturdays from 8 am to 10 pm, Sundays from 8 am to 1 pm. Room Service Available at limited hours.
18% taxes are NOT included in rates, will be charged during check in time.
2 kids from 0 to 10 years old stay free sharing room with their parents
if no show or cancelled during the first 48 hours before arrival will be charged 1 night + 18% taxes as hotel policy
Please note that:
Check in is from 15H
Check out is by 13H
Credit cards are accepted
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hotel Facilities & Policies
- 24 hour reception
- Air Conditioning
- Bar
- Breakfast Included
- Cafeteria
- Child Friendly
- Credit Cards Accepted
- Currency exchange
- Elevator
- Fax Service
- Free Internet Access
- Free Parking
- Hair Dryers
- House Keeping
- Laundry Facilities
- Luggage Storage
- Parking
- Pet Friendly
- Restaurant
- Safety Deposit Box
- Tours/Travel Desk
- Wheelchair Accessible
Cancellation PolicyThis property has a 2 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
DirectionsShow MapHide Map
From: The north. Take Lazaro Cardenas Avenue, look and get Av xalapa then Av. Manuel avila camacho, the hotel is on this av. From: The south. Take the freeway Veracruz-Xalapa, past the Lencero Airport. 13 kilometers on the left past Murillo Vidal AV. turn there and this av, converse to Av. Manuel avila camacho, the hotel is just there
Located Near
Main Downtown square


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Code: s83kr24
Our girls dresses are fun, fashionable and feminine perfect for family gatherings, friends' birthday parties or days out and about. This navy and white striped dress captures one of this season's key trends, nautical. Plus, it's a wearable shape, suitable for year round wear with ballet flats and a cardigan for summer, or tights, boots and a coat for winter.Girls Navy And White Stripe Dress Includes:


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_-/|While Heaven Burns
Credits & Info
- Date
- 07/21/2006
- File Info
- Song
- 1 min 6 sec
- Score
- 4.07 / 5.00
Related Content
Heard in 2 Entries!
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Licensing Terms
- Attribution:
- You must give credit to the artist.
- Noncommercial:
- You may not use this work for commercial purposes unless you make specific arrangements with the artist.
- Share Alike:
- If you alter, transform, or build upon this image, you may distribute the resulting creation only under a license identical to this one.
- Score:
- Rated 4.07 / 5 stars
- Plays & Downloads:
- 3,462 Plays | 677 Downloads
- Share Links:
- Genres:
- Easy Listening - Classical
- None
Author Comments
Rated 5 / 5 stars
just one word...
Rated 5 / 5 stars
This is some crazy final fantasy/fight scene music...ITS AWESOME!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Rated 5 / 5 stars
My head keeps spinning
with every MAC submission I check out I am up against some extremely talented artist's here.....
Very powerful piece, I cant offer any constructive criticism really... umm this is all a bit too good haha....
check out some of my stuff too
will do Flash. I have 2 days to submit the finished version >:D
Need to get that up there soon, its a good deal better then this one.
Rated 5 / 5 stars
Very powerful!
I cannot believe I going to be the first one to use one of your songs in a flash animation. I'm honored to do so, my good sir.
I'm quite honoured you'd honour me by using a song for a flash ;).
Thanks for the review ^^
Rated 5 / 5 stars
Indeed. Chaotic at the start but that's how it should be. ^^
I liked the feeling there and of course the demonic laughter. >:D
Cool piece dude! 5up!
Awesome, glad you liked it :D.
The newer version is much better mastered, and extended... but it's making me so GOD DAMN ANGRY CUZ IT DOESN'T WANT TO FINISH >:(.
But soon enough I hope, thank you for the review ^^.


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Montana Morning. The latest Montana, local and regional news, sports and weather every weekday morning with Peter Christian and the news staff. Schedule M-F 6:00 am - 7:30 am M-Th 8:00 am - 8:30 am
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