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You are here > Home > Baseball Newsstand > Baseball Primer Newsblog > Discussion
Baseball Primer Newsblog
— The Best News Links from the Baseball Newsstand
Wednesday, December 19, 2012
Primer Dugout (and link of the day) 12-19-2012
Honus Wagner quoted in the Toledo News-Bee, December 19, 1912:
Somewhere, Dave Bresnahan is furiously scribbling notes.
Dan Lee is some pumkins Posted: December 19, 2012 at 06:17 AM | 14 comment(s) Login to Bookmark
Tags: dugout, history, honus wagner, jake beckley
Reader Comments and Retorts
Statements posted here are those of our readers and do not represent the BaseballThinkFactory. Names are provided by the poster and are not verified. We ask that posters follow our submission policy. Please report any inappropriate comments.1. Dan Lee is some pumkins Posted: December 19, 2012 at 06:27 AM (#4328322)
No superstars on the pitching staff of today's Birthday Team, but that's a pretty reasonable set of arms.2. What Zupcic? Posted: December 19, 2012 at 10:08 AM (#4328434)
C: Tom Wilson
1B: Russell Branyan
2B: Tony Taylor
3B: Wally Gilbert
SS: Mickey Witek
LF: Tommy O'Brien
CF: Al Kaline
RF: Walt Williams
SP: Geoff Zahn
SP: Bill Wegman
SP: Ian Kennedy
SP: Rex Barney
SP: Jose Silva
RP: Rafael Soriano
RP: Mike Fetters
Commissioner: Ford Frick
Scout: Paul Krichell
MLB Twins: Stan Cliburn and Stew Cliburn
Six home runs in one college game: Marshall McDougall
Not sure if you're tracking these as you do them but do you remember what day has the best team so far?3. Dag Nabbit is a cornucopia of errors Posted: December 19, 2012 at 11:01 AM (#4328496)
As noted at THT, today marks 30 years since the signing of a player on the HoF ballot. Can you figure out which one before clicking on the link?4. Dan Lee is some pumkins Posted: December 19, 2012 at 01:25 PM (#4328675)
By signing, I mean his initial pro contract, not a mid-career free agent signing.
Not sure if you're tracking these as you do them but do you remember what day has the best team so far?I don't off the top of my head. November 26 and April 2 are memorably good, though. February 6 has a guy (G.H. Ruth) who's both a good ace starter and a reasonably decent hitter.
Several Dugout regulars and I are compiling 25-man rosters for all 365 days, which will be used to play a Birthday League. There's no particular team I expect to win it all.
1982 ... my guess is Riger Cemens.6. Brian Posted: December 19, 2012 at 02:17 PM (#4328750)
Edgar?7. Random Transaction Generator Posted: December 19, 2012 at 02:30 PM (#4328767)
I'd guess Edgar or Sammy, simply because they wouldn't have been drafted.8. Crispix reaches boiling point with lackluster play Posted: December 19, 2012 at 02:41 PM (#4328787)
Most drafted players back then would have signed before late December, so it would be someone signed as a teenager from one of the islands.
Sammy would have been pretty young (16?) and Edgar would have been about right (18?).
I'm going to guess Sammy Sosa.
Clemens was a big college star with a gigantic ego, I would imagine he held out as long as possible before the signing deadline. Of course I don't know what the deadline was back then, or indeed what it is now.9. JJ1986 Posted: December 19, 2012 at 02:46 PM (#4328795)
I believe Clemens was drafted in 1983.10. Walt Davis Posted: December 19, 2012 at 03:47 PM (#4328859)
The signing deadline back then was the next draft and you just went back into the pool. See JD Drew and a handful of others. The signing deadline is a fairly recent invention (partly due to JD Drew). It got moved up quite aggressively in the last CBA I think.11. Dag Nabbit is a cornucopia of errors Posted: December 19, 2012 at 05:16 PM (#4328939)
It was pretty common for guys to not sign until 6 months or so later -- e.g. Prior. Sometimes this was due to contentious negotiations but it seemed to happen often with pitchers suggesting it was just a way to give their arm time to rest without starting the minor-league service clock. I suppose it also made sense if the player was going to get a major-league contract.
Anyone know why Jim McGlothlin died so damn young?12. Dewey, Soupuss Not Doomed to Succeed Posted: December 19, 2012 at 05:26 PM (#4328950)
EDITED: nevermind - found out. Leukemia.
Kendrys Morales to Seattle for Jason Vargas.13. RoyalsRetro (AG#1F) Posted: December 19, 2012 at 05:30 PM (#4328956)
I don't get the need to get a sixth starter in return for Morales, but overall it seems like a fair swap.14. Crispix reaches boiling point with lackluster play Posted: December 19, 2012 at 05:33 PM (#4328960)
Hey, Vargas may have been a sixth starter on the Angels, but now that he's on the Mariners ... oh wait.
Morales instantly becomes the Mariners' best hitter by a huge margin. Except of course John Jaso.
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text: My heart sank when I saw the BFI logo and the supporting film with Lottery funds strapline and in my mind I thought "Oh no not another unfunny comedy that can't get commercial funding and is reliant upon lottery subsidy." Nearly two hours later my spirits had barely risen. Its a poor cliche fest reliant on poor sex gags and a thoroughly distasteful character played by O'Dowd. It has jokes that wouldn't have made the cut in a run of the mill 80's sitcom. I expected so much more. Avoid.

subset: commoncrawl


text:
The Shedd Aquarium is famous these days for sharks, dolphins and whales from around the world. But now a new exhibit opens and this show is all about the fish next door. The totally renovated At Home on the Great Lakes exhibit features over 60 species of creatures from just around the corner.
View the full article
GLIN Invasive: Great Lakes fish go on display at Shedd Aquarium
Started by Forum Admin , Jun 12 2013 06:05 AM


text:
January 04, 2012, 04:07 pm
Online piracy bills are flawed
By Casey Rae-Hunter, deputy director, Future of Music Coalition
The music industry has a long history of telling artists to "shut up and sing." Which is why the internet has been so important in amplifying the voices of musicians of every conceivable background. It's also why artists should be wary when powerful entertainment conglomerates push for polices that could undermine free expression, all the while claiming to speak for creators.
Congress is currently considering a pair of well-intentioned but deeply flawed pieces of legislation that threaten to fundamentally change how the internet works. Hollywood and the labels back these bills, which are rightfully being questioned by the broader arts community, from artists and managers to writers and performers.
The bills in question — PROTECT-IP (PIPA) in the Senate and the Stop Online Piracy ACT (SOPA) in the House — have the stated goals of making it more difficult for Americans to access websites that traffic in unauthorized U.S. intellectual property. There's no doubt that foreign-based sites selling MP3s and movies without permission need to be dealt with. The question is how. These bills are the digital equivalent of hazardous tuna nets, except in this case it's speech, and not dolphins, that risk being ensnared.


text:
The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.
ABSTRACT Neurofibromatosis-2 is an inherited disorder characterized by the development of benign schwannomas and other Schwann-cell-derived tumors associated with the central nervous system. The Neurofibromatosis-2 tumor suppressor gene encodes Merlin, a member of the Protein 4.1 superfamily most closely related to Ezrin, Radixin and Moesin. This discovery suggested a novel function for Protein 4.1 family members in the regulation of cell proliferation; proteins in this family were previously thought to function primarily to link transmembrane proteins to underlying cortical actin. To understand the basic cellular functions of Merlin, we are investigating a Drosophila Neurofibromatosis-2 homologue, Merlin. Loss of Merlin function in Drosophila results in hyperplasia of the affected tissue without significant disruptions in differentiation. Similar phenotypes have been observed for mutations in another Protein 4.1 superfamily member in Drosophila, expanded. Because of the phenotypic and structural similarities between Merlin and expanded, we asked whether Merlin and Expanded function together to regulate cell proliferation. In this study, we demonstrate that recessive loss of function of either Merlin or expanded can dominantly enhance the phenotypes associated with mutations in the other. Consistent with this genetic interaction, we determined that Merlin and Expanded colocalize in Drosophila tissues and cells, and physically interact through a conserved N-terminal region of Expanded, characteristic of the Protein 4.1 family, and the C-terminal domain of Merlin. Loss of function of both Merlin and expanded in clones revealed that these proteins function to regulate differentiation in addition to proliferation in Drosophila. Further genetic analyses suggest a role for Merlin and Expanded specifically in Decapentaplegic-mediated differentiation events. These results indicate that Merlin and Expanded function together to regulate proliferation and differentiation, and have implications for understanding the functions of other Protein 4.1 superfamily members.
Article: The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment.[Show abstract] [Hide abstract]
ABSTRACT: The Hippo signalling pathway is an emerging growth control and tumour suppressor pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling and hyperactivation of its downstream effectors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) contribute to the development of cancer, which suggests that pharmacological inhibition of YAP and TAZ activity may be an effective anticancer strategy. Conversely, YAP and TAZ can also have beneficial roles in stimulating tissue repair and regeneration following injury, so their activation may be therapeutically useful in these contexts. A complex network of intracellular and extracellular signalling pathways that modulate YAP and TAZ activities have recently been identified. Here, we review the regulation of the Hippo signalling pathway, its functions in normal homeostasis and disease, and recent progress in the identification of small-molecule pathway modulators.dressNature Reviews Drug Discovery 12/2013; · 33.08 Impact Factor
Article: SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila.[Show abstract] [Hide abstract]
ABSTRACT: Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that are involved in this process, and how the process is regulated, remain poorly defined. In this study, we identify, through a genetic candidate screen, the SCF(Slmb) E3 ligase as a novel negative regulator of the Hippo pathway in Drosophila imaginal tissues via mediation of the degradation of Expanded (Ex). Mechanistic study shows that Slmb-mediated degradation of Ex is inhibited by the Hippo signaling. Considering the fact that Hippo signaling suppresses the transcription of ex, we propose that the Hippo pathway employs a double security mechanism to ensure fine-tuned homeostasis during development.Cell Research advance online publication 19 December 2014; doi:10.1038/cr.2014.166.Cell research. 12/2014;
- [Show abstract] [Hide abstract]
ABSTRACT: The proper control of tissue growth is essential during normal development and an important problem in human disease. Merlin, the product of the Neurofibromatosis 2 tumor suppressor gene, has been extensively studied to understand its functions in growth control. Here we describe experiments in which we used Drosophila as an in vivo system to test the functions of the normal human NF2 gene products and patient-derived mutant alleles. Although the predominant NF2 gene isoform, isoform 1, could functionally replace the Drosophila Merlin gene, a second isoform with a distinct C-terminal tail could not. Immunofluorescence studies show that the two isoforms have distinct subcellular localizations when expressed in the polarized imaginal epithelium, and function in genetic rescue assays correlates with apical localization of the NF2 protein. Interestingly, we found that a patient-derived missense allele, NF2L64P, appears to be temperature sensitive. These studies highlight the utility of Drosophila for in vivo functional analysis of highly conserved human disease genes.PLoS ONE 01/2014; 9(3):e90853. · 3.53 Impact Factor
Page 1
The regulation of cell proliferation is central to controlling the
size and shape of multicellular organisms. Disruption of
proliferation control in an organism can have severe
consequences; improper activation of cell proliferation can
result in the formation of tumors and the development of
cancer. Many genes involved directly with the control of the
cell cycle, and those involved more indirectly with the control
of proliferation, have been identified as oncogenes and tumor
suppressors. Among the known tumor suppressor genes, the
Neurofibromatosis 2 (NF2) gene is particularly intriguing. NF2
is an inherited disorder characterized by the formation of
benign, Schwann-cell-derived tumors on the eighth cranial
nerve, and other benign tumors associated with the central
nervous system (Martuza and Eldridge, 1988). The NF2 gene
encodes a novel member of the Protein 4.1 superfamily,
Merlin, that is most highly related to the ERM (Ezrin, Radixin,
Moesin) subgroup within the family (Gusella et al., 1999).
Members of the Protein 4.1 superfamily all share a conserved
region of ~350 amino acids known as the conserved N-terminal
region (CNTR) or FERM domain (Chishti et al., 1998; Ward
et al., 1998). Some members of the family, including the ERM
proteins, interact with transmembrane binding partners through
the CNTR and localize them to specific membrane domains via
direct interactions between their C-terminal domain and the
actin cytoskeleton (Mangeat et al., 1999).
Merlin shares significant sequence identity with ERM
proteins, particularly in the CNTR. The C-terminal half of
Merlin also contains a predicted coiled-coil domain, but lacks
the actin-binding domain found at the C terminus of ERM
proteins. Nonetheless, Merlin has been shown to interact with
Development 127, 1315-1324 (2000)
Printed in Great Britain © The Company of Biologists Limited 2000
Neurofibromatosis-2 is an inherited disorder characterized
by the development of benign schwannomas and other
Schwann-cell-derived tumors associated with the central
nervous system. The Neurofibromatosis-2 tumor suppressor
gene encodes Merlin, a member of the Protein 4.1
superfamily most closely related to Ezrin, Radixin and
Moesin. This discovery suggested a novel function for
Protein 4.1 family members in the regulation of cell
proliferation; proteins in this family were previously
thought to function primarily to link transmembrane
proteins to underlying cortical actin. To understand the
basic cellular functions of Merlin, we are investigating a
Drosophila Neurofibromatosis-2 homologue, Merlin. Loss of
Merlin function in Drosophila results in hyperplasia of the
affected tissue without
differentiation. Similar phenotypes have been observed for
mutations in another Protein 4.1 superfamily member in
Drosophila, expanded. Because of the phenotypic and
structural similarities between Merlin and expanded, we
asked whether Merlin and Expanded function together to
regulate cell proliferation. In this study, we demonstrate
significant disruptions in
that recessive loss of function of either Merlin or expanded
can dominantly enhance the phenotypes associated with
mutations in the other. Consistent with this genetic
interaction, we determined that Merlin and Expanded
colocalize in Drosophila tissues and cells, and physically
interact through a conserved N-terminal region of
Expanded, characteristic of the Protein 4.1 family, and the
C-terminal domain of Merlin. Loss of function of both
Merlin and expanded in clones revealed that these proteins
function to regulate differentiation in addition to
proliferation in Drosophila. Further genetic analyses
suggest a role for Merlin and Expanded specifically in
Decapentaplegic-mediated differentiation events. These
results indicate that Merlin and Expanded function
together to regulate proliferation and differentiation, and
have implications for understanding the functions of other
Protein 4.1 superfamily members.
Key words: Protein 4.1, ERM, FERM domain, Apical membrane,
Neurofibromatosis-2, Merlin, expanded, Drosophila melanogaster
The Neurofibromatosis-2 homologue, Merlin, and the tumor suppressor
expanded function together in Drosophila to regulate cell proliferation and
Brooke M. McCartney*, Rima M. Kulikauskas, Dennis R. LaJeunesse and Richard G. Fehon‡
Developmental, Cell and Molecular Biology Group, Duke University, Durham, NC 27708-1000, USA
*Present address: Lineberger Comprehensive Cancer Center, Department of Biology, CB#3280 Coker Hall, University of North Carolina, Chapel Hill, NC 27599-3280,
‡Author for correspondence (e-mail: firstname.lastname@example.com)
Accepted 20 December 1999; published on WWW 21 February 2000
Page 2
the actin cytoskeleton through an N-terminal binding region
(Xu and Gutmann, 1998). Consistent with this observation,
overexpression of Merlin in vertebrate cultured cells causes
transient alterations in the F-actin cytoskeleton (Gutmann et
al., 1999). Work from several laboratories indicates that Merlin
can form homotypic dimers, and heterotypic dimers with ERM
proteins, but the functional significance of these interactions is
not known (Gronholm et al., 1999). Other Merlin binding
partners include NHE3-RF, the Na+/H+exchanger regulatory
factor that also binds to ERM proteins (Reczek et al., 1997;
Murthy et al., 1998), and βII-spectrin (Scoles et al., 1998).
Although transmembrane partners for Merlin have not been
identified yet, the hyaluronin receptor CD44, the adhesion
molecule ICAM-2, the cystic fibrosis transmembrane
conductance regulator and the B-adrenergic receptor have been
shown to bind ERM proteins directly or indirectly (Tsukita et
al., 1994; Hall et al., 1998; Heiska et al., 1998). In addition,
recent studies indicate that ERM binding is essential for proper
recycling of the B-adrenergic receptor, and thereby regulation
of its activity (Cao et al., 1999). Thus, it seems that ERM
proteins and perhaps Merlin may bind to and regulate the
functions of a number of transmembrane proteins.
Nonetheless, it is not yet clear why loss of Merlin function
results in misregulation of proliferation.
The discovery that a member of the Protein 4.1 superfamily
has a tumor suppressor function was initially surprising
because its members traditionally have been considered to
play a structural role in linking transmembrane proteins to the
cytoskeleton. However, another family member, Drosophila
expanded (ex), has also been shown to have a tumor
suppressor function; loss of ex function can lead to the
development of hyperplastic imaginal discs and overgrown
adult structures such as the wing (hence the name expanded;
Boedigheimer and Laughon, 1993). Expanded has a divergent
CNTR and a C-terminal region that contains a putative coiled-
coil domain and three potential SH3-binding domains
(Boedigheimer et al., 1993). Like NF2, ex seems to function
in regulating proliferation, and loss of its function does not
appear to significantly disrupt patterning of the affected
imaginal discs.
We have identified and characterized an NF2 gene
homologue in Drosophila called Merlin (Mer) and shown that
it functions similarly to NF2 in regulating cell proliferation
(McCartney and Fehon, 1996; LaJeunesse et al., 1998). To
understand its cellular roles, we have begun to investigate the
molecular framework in which Drosophila Merlin functions by
identifying interacting genes and proteins. Given their
phenotypic and structural similarities, and previous evidence
that other family members can interact heterotypically, we
were interested in the possibility that Merlin and Expanded
might function together to regulate proliferation during
Drosophila development. In this study, we show that Merlin
and expanded display dose-sensitive interactions that suggest
physical interactions between the proteins that they encode.
Cell culture and blot overlay assays indicate that Merlin and
Expanded interact directly via the CNTR of Expanded and the
C-terminal domain of Merlin. Removal of all Merlin and
Expanded function in double mutant clones results in severe
differentiation defects that are not observed with either
mutation alone. Genetic interactions between Mer, ex and
decapentaplegic (dpp) are consistent with the notion that
Merlin and Expanded positively regulate DPP function. Taken
together, our results indicate that Merlin and Expanded
function cooperatively in regulating cell proliferation and
differentiation in developing epithelial cells.
Drosophila stocks, genetic analysis and
All Drosophila cultures were maintained on standard corn meal,
yeast, molasses and agar medium. The Mer alleles used in this study
were described previously (Fehon et al., 1997; LaJeunesse et al.,
1998). ex alleles were a gift from M. Boedigheimer and P. Bryant.
K. Wharton provided the dpphr56allele used in this study and the
dpp-lacZ (B3.0) stock was obtained from the Bloomington
Drosophila stock center. Whole-mount preparation and analysis of
adult eyes, wings and legs were described previously (LaJeunesse et
al., 1998). The distance between wing hairs as a measure of cell size
was determined using the measure function in NIH Image. Scanning
electron microscopy was preformed as described previously (Rebay
et al., 1993). Somatic mosaic clones of Mer4were generated at 36
hours after egg laying (AEL) using the FRT/FLP system (Xu and
Rubin, 1993). Mer−,ex−mutant clones were generated by gamma
irradiating (1100 rad) w1118sn3Mer4/w1118sn3Mer4; P{w+,
UpMer+} ex+/exe1larvae at 72 hours AEL. Immunolocalization was
conducted as described (McCartney and Fehon, 1996) with the
following antibodies: anti-Merlin (1:7500 dilution; McCartney and
Fehon, 1996), anti-Expanded (1:500, provided by M. Boedigheimer
and P. Bryant), anti-β-gal (1:1000, Promega), anti-ELAV (1:500,
provided by I. Rebay and G. Rubin)
Expression in Schneider-2 cells
Schneider-2 (S2) cell maintenance, transfection and fluorescent
staining were performed as described previously (Fehon et al., 1990).
Full-length Expanded (EX1-1429, EX+) and an N-terminal Expanded
fragment (EX1-399; both provided by M. Boedigheimer and P. Bryant)
were subcloned into the MetallothioneinA promoter vector pRmHa3
(Bunch et al., 1988). Three additional Expanded C-terminal fragments
were PCR amplified, Myc-tagged and subcloned into pRmHa3:
EX773-1429, EX773-1065and EX1066-1429. Sequencing confirmed that no
PCR errors were introduced. Myc-tagged full-length (MER1-635,
MER+), N-terminal (MER1-349) and C-terminal (MER345-635) Merlin
fragments in pCaSpeR-hs were described previously (LaJeunesse et
al., 1998). Expression of Expanded constructs was induced by
addition of 0.7 mM CuSO4 for a total of 12-16 hours. Expression of
Merlin constructs was induced during this time by a 20 minute
incubation at 38°C followed by 6 hours at 25°C. Cells were stained
with anti-Expanded (1:500), anti-Merlin (1:2000) or anti-Myc 9c10
Blot overlay experiments
DNA fragments generated by PCR corresponding to MER1-306,
MER345-636, MER350-599, MER522-635, EX1-399and EX773-1429 were
subcloned into the GST fusion protein vector pGEX3 (Pharmacia).
The MER350-599 fragment was cloned as an in-frame dimer and
therefore contains two tandemly repeated copies of this portion of
the protein. The MER1-635full-length construct was generated by
cloning a MunI restriction fragment that contains the entire Mer
coding sequence in frame into pGEX. Fusion proteins were expressed
in BL21 cells and purified as described (Frorath et al., 1991). Purified
proteins (30-100 µg/ml in 50 mM NaHCO3, pH 8) were labeled with
the addition of 75 µg/ml NHS-LC biotin (Pierce) for 2 hours on ice,
followed by the addition of 50 mM glycine. Proteins were dialyzed
at 4°C for 16 hours in 100 mM sodium phosphate pH 7.0/50%
glycerol. Target proteins were also expressed as GST fusions. To
B. M. McCartney and others
Page 3
1317Merlin and Expanded interact
make crude cell lysates, overnight cultures were diluted 1:20 in LB
with 100 µg/ml ampicillin and grown for 90 minutes at 37°C. Protein
expression was induced with the addition of 2 mM IPTG for 3 hours
at 15-18°C. Cells were then pelleted, resuspended in 1/4 volume SDS
sample buffer and separated on 3-15% gradient acrylamide gels.
Proteins were transferred onto nitrocellulose membranes. Blots were
blocked for 30 minutes in 5-10% milk/TBS/0.1% Tween followed by
sequential 1 hour incubations in 0.2 mg/ml avidin and 0.1 mg/ml
biotin, respectively (the avidin and biotin blocks were omitted in
some experiments). Blots were incubated with biotinylated probes at
0.15 to 3.0 µg/ml in 1-5% milk/1× TBS/0.1% Tween-20 for 12-16
hours at 4°C. Blots were then incubated with ExtrAvidin (Sigma) at
1:2000 in 5% milk/TBS/Tween for 1-2 hours at room temperature.
Binding was detected with SuperSignal chemiluminescent reagents
Merlin and ex display similar phenotypes and
interact genetically
Hypomorphic alleles of either Mer (Mer3) or ex (ex697) result
in very similar adult wing and eye phenotypes. In both cases,
mutant adults displayed enlarged wings due to an increase in
cell number rather than an increase in cell size (Fig.
1D,E,G,H,J). In fact, the cell size in the mutants appeared to
Fig. 1. Merlin and expanded interact
genetically. (A-C) Scanning electron
micrographs of adult eyes (anterior is to the
right). (A) Wild-type eye. (B) Adults
hemizygous for Mer3exhibit a weakly
roughened, reduced eye with expansion of
ventral and posterior head cuticle, and
development of ectopic vibrissae, the bristles
found ventral and anterior to the eye (arrow).
(C) Recessive loss-of-function mutation ex697
dominantly enhanced the small, roughened
eye phenotype exhibited by Mer3. In addition,
numerous interommatidial bristle duplications
were observed. (D-F) Wings from adult male
flies. (D) Wild type. (E) Hemizygotes for
Mer3have broadened wing blades. They may
also have disruptions of the posterior cross
vein (not shown). (F) Recessive loss-of-
function mutation ex697dominantly enhanced
the Mer3/Y broad wing phenotype producing
significantly larger wings that show an
increased frequency of posterior cross-vein
disruptions (arrow). Due to the size of the
wing, the blade often folds during mounting
(arrowhead) (G-I) Wings from adult female
flies. (G) Wild type. (H) Adults homozygous
for ex697display a broad wing phenotype
characterized by disruption of the posterior
cross vein (arrow) and the anterior cross vein
(arrowhead). (G) Recessive loss-of-function
mutation Mer1dominantly enhanced the ex697
broad wing phenotype producing a
significantly larger wing. (J) Comparisons of
mean wing area and cell size of genotypes
shown in D-I. Note that wild-type male wings
are smaller than wild-type female wings. By
use of the t-test, the increases in wing area
observed in the mutants were shown to be
significant when compared to wild type
(P<0.01). Furthermore, the distance between
wing hairs in wing compartment 4 was
determined as a measure of cell size. These
values indicate that the increase in wing area
in the mutants is not due to an increase in cell
Page 4
be slightly decreased (Fig. 1J). Furthermore, this expansion
in wing area was often accompanied by the disruption or
complete absence of the posterior cross vein (Fig. 1H arrow).
In addition, the anterior cross vein was sometimes disrupted
in ex697adults (Fig. 1H, arrowhead). Mer and ex mutants have
smaller, weakly roughened eyes (Fig. 1B; Boedigheimer and
Laughon, 1993). Histological sections of Mer3eyes revealed
only minor perturbations in interommatidial organization and
no obvious disruptions in ommatidial polarity (data not
shown). Concomitant with the reduction in eye size was an
apparent expansion of the ventral peripheral head cuticle and
the development of ectopic vibrissae (Fig. 1B arrow).
Although stronger alleles of both Mer (Mer1, Mer2, Mer4) and
ex (exe1, a null allele) result in lethality, Mer mutant larvae
did not develop the hyperplastic discs characteristic of ex
mutant larvae (data not shown; Boedigheimer and Laughon,
Dose-sensitive genetic interactions have been shown to be a
reliable indicator of functional interactions between genes
(Chang et al., 1994). Reduction of ex function in the Mer3
hemizygous background with either ex697 or exe1resulted in an
enhancement of the Mer3 head phenotypes (Fig. 1B,C); the
adult eye was reduced in size, more ectopic head cuticle and
vibrissae were observed, and the bristles normally found
between ommatidia were often duplicated and disorganized
(Fig. 1C). Those ommatidia that did form contained the normal
complement of photoreceptors, however (data not shown). In
addition, Mer3wing area and the frequency of posterior cross
vein disruptions increased when ex function was reduced (Fig.
1E,F,J arrow). Consistent with these observations, reduction of
Mer function in ex697mutants caused an increase in ex697wing
size (Fig. 1H-J).
Merlin and Expanded colocalize in Drosophila
tissues and cultured cells
If the observed genetic interactions between Mer and ex reflect
molecular interactions between the proteins that they encode,
then the subcellular distribution of these proteins should be
similar in expressing tissues. We have previously reported that
Merlin is localized in a punctate distribution at the apical
plasma membrane in the region of the adherens junction and
in the cytoplasm (McCartney and Fehon, 1996), and Expanded
has been reported to localize to the apical membrane domain
(Boedigheimer and Laughon, 1993). To confirm that they are
similarly distributed, we double labeled the two proteins in
imaginal disc cells and found that the staining patterns were
almost indistinguishable (Fig. 2A,B).
Given their clear colocalization, we asked whether the
localization of Merlin in this specific distribution is dependent
on the presence of Expanded. We examined Merlin in exe1
wing imaginal discs and did not find any significant alterations
in Merlin localization (not shown). In a complementary
experiment, we generated Mer4mitotic clones at 36 hours AEL
using the FRT/FLP system and examined Expanded
localization in the Mer mutant tissue. Two notable results were
observed. First, we detected no alteration in Expanded
localization in the absence of Merlin protein, indicating that
Expanded does not depend on Merlin for proper subcellular
localization. Second, there was an apparent increase in the level
of Expanded autonomously in the Mer4tissue as compared
with the heterozygous background (Fig. 2C,D arrows indicate
a border of the clone). This observation indicates either that
loss of Merlin results in increased Expanded expression or that
an Expanded epitope is masked in the presence of Merlin
protein, perhaps due to direct interactions between these
Although we did not detect interdependence between Merlin
and Expanded for subcellular localization in tissues, it
remained possible that these proteins physically interact. For
example, each protein could localize to the apical junctional
domain of intact tissues via interactions with other proteins in
this region of the cell. To examine possible interactions
between Merlin and Expanded, we cotransfected constructs
expressing these proteins into cultured S2 cells that lack an
apical junctional domain to more readily detect possible
interactions between them. The localization of Merlin
expressed in cultured cells follows a very specific pattern;
Merlin is first found at the plasma membrane and is then
trafficked into the cytoplasm where it is associated with
endocytic compartments (McCartney and Fehon, 1996).
Expanded is endogenously expressed at levels virtually
undetectable by immunofluorescence in S2 cells (data not
shown). When full-length Expanded was expressed in S2 cells,
B. M. McCartney and others
Fig. 2. Merlin and Expanded colocalize at the apical membrane
domain in polarized epithelial cells. (A,B) Tangential confocal
optical section of a wing imaginal disc from a wild-type third instar
larva double labeled for Merlin (A) and Expanded (B) revealed that
these proteins colocalize at the apical junctional domain in imaginal
disc cells. Expanded appears to be less highly expressed at the
presumptive wing margin (B). (C,D) Homozygous Mer4mutant
clones were induced 36 hours AEL and the wing imaginal discs from
third instar larvae were double labeled for Merlin (C) and Expanded
(D). A tangential confocal optical section through the apical surface
of the disc reveals a clone of Mer4mutant tissue identified by loss of
Merlin labeling (C, arrow indicates the border of the clone). An
apparent increased level of Expanded was observed in the Mer4
mutant tissue (D, arrow indicates the border of the clone).
Page 5
1319 Merlin and Expanded interact
it localized in the cytoplasm in a pattern significantly different
from that of Merlin alone (Fig. 3A). When these two proteins
were coexpressed, the pattern of Merlin localization was
unchanged (Fig. 3Ac; McCartney and Fehon, 1996). In
contrast, Expanded localization was altered so that it
colocalized with Merlin both at the plasma membrane and in
cytoplasmic compartments (Fig. 3Aa-c), suggesting a physical
interaction between Merlin and Expanded.
We next asked which domains of Merlin and Expanded are
responsible for this interaction by coexpressing fragments of
these proteins and comparing their localizations. Although
coexpression of wild-type Expanded (EX+) with MER1-349
had no effect on Expanded localization (Fig. 3Ad,e),
coexpression with MER345-635
relocalization of Expanded (Fig. 3Af,g). In complementary
experiments, we observed that the localization of EX1-399was
altered by coexpression of full-length Merlin (MER+) (Fig.
3Ba-c). The subcellular localization of other, more C-terminal
EX fragments (EX773-1429) was not altered by MER+
coexpression (Fig. 3Bd-f). Taken together, these results
suggest that the CNTR of Expanded (amino acids 1-399)
interacts with the C-terminal half of Merlin (amino acids 345-
635). To test this hypothesis, we coexpressed EX1-399with
MER345-635and found that these fragments colocalize at the
plasma membrane (Fig. 3Bg,h). It is worth noting that these
results indicate that a reciprocal interaction between the C-
caused a dramatic
terminal domain of Expanded and the N-terminal domain of
Merlin does not appear to occur.
Merlin and Expanded interact directly
To complement and extend the colocalization experiments, we
examined the ability of the Merlin and Expanded proteins to
interact directly in vitro. Previous blot overlay experiments
with ERM proteins have shown that sequences derived from
the ERM CNTR bind to the ERM C-terminal tail region
(Bretscher et al., 1995). Recent results using the yeast two-
hybrid system have confirmed these interactions, and have
shown that heterotypic dimers can form between Merlin and
ERM proteins (Gronholm et al., 1999). We therefore employed
a blot overlay assay to determine if the CNTR of Expanded
interacts directly with the C-terminal tail of Merlin. As shown
in Fig. 4B, the CNTR of Expanded (EX1-399) binds strongly to
full-length Merlin, and to a C-terminal Merlin fragment
(MER522-635). These results are consistent with a head-to-tail
heterodimeric interaction between Merlin and Expanded, as
suggested by experiments with S2 cultured cells. However, we
did not detect interactions between Expanded and the larger C-
terminal Merlin fragment (MER345-635), the same fragment that
interacted with Expanded in the cell culture assay. This may
indicate that in vitro the MER345-635fragment folds into an
inaccessible configuration. In addition, EX1-399bound to a C-
terminal Expanded fragment (EX773-1429, Fig. 4B), suggesting
Fig. 3. Expanded is redistributed in response to Merlin in S2 cells. Singly or doubly transfected S2 cells were treated as described in Materials
and Methods. EX and MER proteins were stained using specific antibodies for each protein, or anti-Myc as necessary. (A) EX+associates with
the C-terminal half of Merlin. EX+is localized in a punctate distribution in the cytoplasm when ectopically expressed in S2 cells (a). When
coexpressed with full-length Merlin (MER+), EX+colocalizes with MER+at the membrane and in large cytoplasmic compartments (b-c). The
CNTR of Merlin is not necessary or sufficient for this interaction as EX+does not colocalize with MER1-349(d-e), but does colocalize with
MER345-635(f,g). (B) Merlin associates with the CNTR of Expanded. The CNTR of Expanded (EX1-399) is sufficient for an interaction with
MER+(a-c), whereas a C-terminal fragment of Expanded (EX773-1429) is unable to colocalize with MER+(d-f). Coexpression of EX1-399with
MER345-635(g,h) and indicates that the CNTR of Expanded colocalized with the C-terminal domain of Merlin at the plasma membrane.


text:
|Property type
|Minimum Stay
|4 nights
Villa Melody is a town house in the West Golf area of El Gouna. Fully furnished, with 3 bedrooms, it accommodates up to 6 persons. It has 3 furnished terraces at all levels, sun beds and direct access to the sea-water lagoon. Enjoy panoramic views of the famous El Gouna golf course from each terrace. The house has been designed and furnished to the highest standard of living. It is a combination of modern design and Egyptian Nubian style.
In addition to the large private ground floor terrace with very comfortable seating and fascinating views over the lagoon, the town house has additionally a large roof terrace with fantastic views over the area of El Gouna, the mountains and the 4th hole of the golf course. Experience any sort of holiday you can imagine - from a perfect recreation to a real action-adventure, using all opportunities in El Gouna
At Villa Melody you find everything you need to enjoy your holidays in the sun - 365 days a year.
Additional remarks: Airport transfer from Hurghada to El Gouna - Villa Melody - can be arranged upon request against additional charge between 40 € to € 60 depending on number of person and luggage.
WiFi Internet connection is available, with additional charges
Instructions are given by a contact person upon arrival.
Refrigerator can be filled on arrival day upon request at additional charges
Public transport in El Gouna: El Gouna offers a variety of transportation options within the resort, from regular shuttle bus and taxi boat to limousine and tok tok service. Bus stop of West Golf Line is near Villa Melody.
A weekly shutle bus ticket is 20 egyptian pound (€ 3-4). Fee for the tok tok service within El Gouna is between 5-10 egyptian pound (around € 1).
Financial Information: Local currency is the Egyptian Pound (EGP or LE). Most of the six banks have ATMs, which take bank cards and major credit cards. Stand-alone ATMs are also available in some hotels as well as the Downtown and Marina areas. All El Gouna banks offer official currency exchange services, but it is advisable to arrive with either US$, UK£, Euros, or travelers checks to simplify money transactions. Please note that most El Gouna restaurants and retailers generally do not accept credit cards, preferring cash transactions in Egyptian pounds.
private beach, lagoon, seaview, beach, swiming, sailing, surfing, kite surfing, golf, relax and enjoy, quiteness
Other Activities: Safari, squad driving, go cart, paint ball
Golf: El Gouna's 18-hole championship course boasts year-round golfing in a setting where players can feast their eyes on stunning views of mountains and endless water as the course challenges the strength, ingenuity, and skill of novice and professional alike.
The Golf Club welcomes golfers of all levels; tee-off times must be reserved in advance and handicap proof is mandatory. The club offers a full range of retail products, rental equipment and driving range facilities as well as PGA tuition. For non-golfers, don't miss the weekly Golf Introduction with PGA Professionals on the driving range.
Villa Melody is opposite 4. hole
Ski: Waterski - There are courses for wakeboarding, waterskiing, wakeskating, wakesurfing, kitesurfing as well as single sessions in all disciplines available from private companies.
|Rate Period
|Weekend Night
Mar 1 2014 - Jul 31 2015
4 night minimum stay
My Standard Rate
4 night minimum stay
|No additional mandatory fees
|Refundable damage deposit
WiFi € 20,00 pro Woche / € 3,00 pro Tag
Für kürzere oder langfristige Anmietung bitte anfragen. Eine Zahlung ist auch mit PayPal möglich
Anzahlung von € 100,00 pro Woche nach Buchung. Restzahlung 4 Wochen vor Mietbeginn
Payment is usually accepted in the quoted currency (EUR) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.


text:
10 years of experience
Accepting new patients
10 years of experience
Accepting new patients
University Park
6901 Snider Plz
Ste 130
Dallas, TX 75205 Phone number & directions
6901 Snider Plz
Ste 130
Dallas, TX 75205 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Sireesha Janga:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
Have you visited Dr. Janga? Share your experience.
Write a Review
Write a Review
Specialties & Research
Dr. Sireesha Janga, MD is board certified in Internal Medicine.
Education & Awards
Dr. Janga graduated from Kurnool Medical College.
Dr. Janga has 6 hospital affiliations:
- Dallas Regional Medical Center
- Doctors Hospital Dallas
Home > Find an Internist > TX > Dallas Internists > Dr. Sireesha Janga, MD
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- Additional Information
- Dr. Sireesha Janga MD is a female Internist, has 10 years of experience and practices in Internal Medicine.
- Where does Dr. Sireesha Janga practice?
- Dr. Sireesha Janga has 1 office location.
Dr. Sireesha Janga practices Internal Medicine near Dallas, TX.
See Dallas Internists.


text:
Large Scale Botnet Brute Force Attack Targets WordPress Sites, Over 90K Servers Affected
Own a website that runs on WordPress? You'll want to pay attention to this story. Since last week, there's been an ongoing brute-force attack that's targeted stand-alone WordPress installations. Like most login prompts, WordPress' will lock you out for some time after putting in an incorrect password a certain number of times, but there's an easy way to get around that by those who don't mind putting the effort in: use multiple IP addresses.
A handful of IPs wouldn't be too worrisome, but this particular attack has been monitored to use up to 90,000 of them. Clearly, there's no simple way for anyone to block such a large number of addresses from their site, and that's hardly an ideal solution anyways.
The attack has been seen to test up to 1,000 different passwords, using the default WordPress administrator login of "Admin". If your password is truly secure, you likely have nothing at all to worry about. If you've been lazy with your admin password, you'll want to go change it to something secure now. Once a site is compromised, a backdoor is installed that adds your server to this growing botnet, seeking out other sites and brute-forcing them.
As an article at Krebs on Security suggests, there are a couple of very easy steps you could take that will help amp up the level of security on your WordPress site. In addition to a secure password, you could install a plugin from Duo Security which enables two-step authentication. Going the hardcore route, you could tweak your security to allow only specific IP addresses access to the WordPress admin (this isn't ideal for those who have dynamic IPs, however).
Though WordPress is the target of this attack, there's really no exploit to speak of. The only thing WordPress could change is restricting the total number of admin login attempts regardless of the IP address being used. But again, that's a bit on the hardcore side. A strong password helps protect against this sort of attack extremely well.
What a shame. I'm all for strong passwords, but this is ridiculous.
I don't think having up to 5 or so chances to login for an admin account would be that hardcore. I though that was starting to be a standard so brute force is pretty much made useless for certain periods of time. Then again I would hope people that are admins would understand that leaving your password as something easy would be the first thing not to do but I'm sure people do it.
Its kinda funny though this comes up and while I don't have any admin access to a wordpress site I went and tested my usual passwords I use. I was shocked my "hard" password which I think is simple to remember beat out my buddy's military password that seems very difficult to type in and remember. Either way people should be educated enough that regardless of the service they use to have a good medium but hopefully strong password.
Coincidentaly, we made this point in one of our Daily Influency Videos , just this week: http://answerguy.com/videopost/you-cant-build-a-web-site-in-one-hour-admin-security/
It's a real problem, and the fact that so many WordPress sites are being hammered hard enough to get seriously slow needs to just work its way out, but the security part is actually pretty simple, eh?
6Scan's WordPress plugin (http://wordpress.org/extend/plugins/6scan-protection/) has built-in protection against dictionary and brute force attacks as part of its "login security" feature.
To ensure you are protected against almost any type of attack, make sure to run a free vulnerability scan on your WordPress site directly from 6scan.com, and fix any vulnerability found (6Scan offers manual fix instructions for vulnerabilities entirely free).
Solve all your security problems with a single click, No expertise required!
For more details, visit www.6scan.com


text: Chargers WR Keenan Allen potentially out for rest of th... Chargers WR Keenan Allen potentially out for rest of th... Jon Lester featured on this week's Sports Illustrated c... Jon Lester featured on this week's Sports Illustrated c... Marcus Mariota shines on Letterman Marcus Mariota shines on Letterman Bobby Petrino's unique bonus Bobby Petrino's unique bonus Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Phillies place Roy Halladay on 15-day disabled list with shoulder inflammation by John Otano Email Posted: Mon May. 6, 2013 Roy Halladay is heading to the disabled list with shoulder inflammation. (Photo by Jason Miller/Getty Images)The Philadelphia Phillies have placed veteran right-hander Roy Halladay on the 15-day disabled list with inflammation in his right shoulder, the team said on Monday. Phillies general manager Ruben Amaro Jr. told reporters on Sunday that Halladay was going to visit Dr. Lewis Yocum about the soreness Halladay was feeling in his right shoulder. Lefthander Joe Savery has been recalled from the Phillies Triple-A affiliate to take Halladay's place on the big league roster.In his last two starts, Halladay has allowed 17 earned runs and 13 hits in six innings of work. Halladay has a 8.65 ERA and is 2-4 in seven starts this season for the Phillies. Promoted Stories Tweet Story0 Share Story0 Comment0 More Share Story0 Share Story0 Stumble It0 Print0 Comments


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Uk hotels with bedrooms visible from bar/dining room(35 Posts)
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Ratings based on 755 Verified Reviews
They paid and stayed. We double-checked.
4.3 Room cleanliness
4.1 Service & staff
4.2 Room comfort
4.1 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Otherby A verified travelerfrom Paris
Personnel très accueillantPosted Dec 19, 2014
Pros: La gentillesse du personnel. L'ambiance. Beaucoup de musiciens en tournée.
Cons: Le service au bar
Location: Le quartier n' a par contre aucun intérêt. Loin de tout.
Hotel très utilisé par les maisons de disques et les musiciens en tournée, quelque soit le spectacle.
for Everyoneby A verified traveler
Nice boutique hotel especially for 20s to 40sPosted Dec 10, 2014
Great service, modern rooms, very polite young staff. The lobby, reception and bar area is insanely loud evenings and packed on weekends. The 'quiet room' usually has an unwatched TV blaring but you can switch it off. Bar blares awful music during the day. But your room is always a safe haven.
for Everyoneby A verified travelerfrom warszawa
Esthetic hotel different from traditional onePosted Dec 7, 2014
Great location, beautiful rooms and Westfield shopping centre nearby.
for Everyoneby A verified traveler
Perfect for a night awayPosted Nov 27, 2014
Pros: Everything.
Cons: Nothing really.
We booked this purely on location, as we needed to be in Shepherds Bush. We were very pleasantly surprised. The hotel is very well maintained, the staff are fantastic, and the room was perfect.
for Everyoneby A verified travelerfrom UK
Convienient & comfortablePosted Nov 26, 2014
Pros: Very close to Tube (less than 5mins) and all the convieniences of Westfield shopping centre. Very large room size and twin rooms available.
Cons: I have never stayed in a hotel where spa access was an additional charge, I think this is inappropriate. Also glass bathroom doors do not appeal to me
Location: Great location, close to shopping centre and also tube station on the central line.
Very nice hotel in good location. Large rooms and also extremely quiet given its location.
by A verified travelerfrom bath
convenient for central london businessPosted Nov 20, 2014
Pros: rooms are large , beds are large , great commute into london
Cons: better pillows better room service menu nicer toiletries in room
Location: westfield shopping
staff seem to pick and choose level of friendliness to each guest , stayed twice now and not great reception not great drainage in rooms , reported it and still not fixed twice internet charged at wrong rate
for Everyoneby A verified travelerfrom San Francisco
Posted Nov 12, 2014
Pros: Location to Shepards Butsh tube station and proximity to shopping and food.
Cons: Taxi's were hard to get, had to walk to another street, no bellman.
The executive rooms were very, very spacious by London standards. Comfortable beds, smallish bathrooms, but the size of the room was outstanding!
by A verified travelerfrom Bournemouth
Never even got to stay here!Posted Nov 11, 2014
Pros: Didn't stay at this one
Cons: Inform that book out prior to arrival
Arrived at K West at 6.30pm giving me plenty of time to get ready and go to my event at 7.30pm however at check in desk was informed I would have to be booked out to sister hotel Lancaster London - no pre warning. Was told a taxi would be coming and eventually they placed me in the Bar Managers car to Lancaster Hotel. Everyone disappeared in a panic as they were unsure at K West how to get me to Lancaster and back to my event (which I was late for) Receptionist on desk was trainee with no clue at all at K West. Customer service poor except Bar Manager. Next day at Lancaster asked for comp Breakfast for the inconvenience caused and they said I wasn't staying there. On return from my stay in London I called and have now had an answer after calling 3 times (finally now have a reply). 4 given for Hotel staff for Carlos as out of the whole team at K West Carlos should be given a pay rise. Very friendly and accommodating and went over his duties as a Bar Manager to get me to a venue on time in his personal car.
for Everyoneby A verified travelerfrom Glouceatershire
Not 4 star!Posted Nov 10, 2014
Unfortunately the water was almost cold when I went to take a shower in the morning, really not very pleasant, surely that is a basic requirement. The fixtures and fittings are starting to fall apart, the window frame was very shabbily fitted. Sort of felt like a lot of funky features were put in place with many corners cut - was surprised it was 4 star, expected better!! But was ok just to stay over night with a friend, certainly not a romantic get away!! Staff actually not that friendly, more cool and aloof.
for Everyoneby A verified travelerfrom Sussex
Nice hotel but customer service could be betterPosted Nov 6, 2014
Pros: Comfortable. Good location
Cons: Customer service - room check in times
Location: Good location, 2 minutes walk from Westfield and 10 mins taxi to the Apollo
Turned up to check in at 2pm like told and had to wait nearly an hour to get in the room which was really annoying as we had limited time there. Other than that the hotel was nice and comfortable.


text:
- Home »
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News Items 1 - 5 of 70
Statement on ALJ Delay Lawsuit
December 19, 2014
America's hospitals are investing enormous time and resources to enhance our country's readiness for the new and real threat of Ebola. Learn More
Maryland TPR Collaborative Recognized for Innovative Approach to Reshaping Health Care
December 17, 2014
The American Hospital Association (AHA) today awarded the Carolyn Boone Lewis Living the Vision award to the Maryland TPR Collaborative, for its work to improve the health of its communities through actions that go beyond traditional hospital care. Learn More
Statement on Consolidated and Further Continuing Appropriations Act
December 10, 2014
When disaster strikes, Americas hospitals are there. Learn More
Statement on Annoucement of Ebola Treatment Centers
December 02, 2014
America's hospitals are investing enormous time and resources to enhance our country's readiness for the new and real threat of Ebola. Learn More
Harold L. Krueger, Jr. Receives AHA's Shirley Ann Munroe Leadership Award
November 25, 2014
Harold L. Krueger, Jr., CEO of Chadron Community Hospital & Health Services (CCH&HS) in Chadron, Neb. is the 2014 winner of the American Hospital Association's (AHA) Shirley Ann Munroe Leadership Award. Learn More
- AHA News Now: AHA opposes efforts to weaken moratorium on physician-owned hospitals
- AHA News Now: AHA seeks candidates for Board of Trustees
- AHA News Now: Court dismisses AHA lawsuit on Medicare appeals
- AHA News Now: GAO announces six new MACPAC members
- AHA News Now: MedPAC considers post-acute payment recommendations for 2015
- Future AHA Annual Meeting Dates
Washington, D.C.


text:
Rush Limbaugh
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Wall Street Journal
Jim Bohannon
Coast to Coast
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Bob Brinker
Dave Ramsey
For any and all Law advice, visit:
On Dec. 18, 2014 at 6:30pm there will be a fundraiser including a bake sale, silent auction, and a talent show in honor of Lori Myers at CHS. Lori is fighting breast cancer and has been given so much, she now wants to give back. The benefit will honor Randy Humphries; Randy has been fighting brain cancer for 27 months.
FREE Movie Night
The Anaconda AOH, Locker Room and Chamber of Commerce are sponsoring a FREE movie night on Dec. 20, 2014 at 1pm at the Historic Washoe Theatre. The movie will be Rio 2, rated G. Everyone is invited to join in on the fun! For more info call Frank at 406-563-7278.
KXTL is teaming up with The Old Works to promote "Troon Rewards". Visit kxtl.com and click on the Troon Reward link at the top. By joining Troon Rewards you can earn free rounds of golf and discounts on merchandise and fees. You also receive special offers, access to exclusive events and Callaway promotions. "The more you play, the more you save". So visit kxtl.com click and the Troon Rewards link, for more information and to sign up today!
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SF:That seems like the hallmark of how your run Mary's Shelter: you don't only care about the babies and the kids, but you respect the parents. Is this a deliberate decision, to approach your ministry this way?KW: Absolutely. We don't just save the life of the baby. We're out to save the life of the mother, and the father, if he's in the picture. We crack up when we hear a pro-choicer saying, "You pro-lifers only care about the white baby in your belly." That's the biggest lie out the … [Read more...]
At the Register: Saving Lives, Not Just Solving Problems
Today: people who aced their design assignment -- but instead of moving along, they went on to save the lives of thousands of premature infants in the third world.Shout out to Chunmiao Little Flower! These guys are amazing. … [Read more...]
At the Register: Should Catholics support UNICEF?
Absolutely not. Here are a few reasons why.And for goodness' sake, if a cute little Spiderman or vampire shows up on your porch with an orange UNICEF box, don't harangue the poor kid. Just say, "No, thanks, we support better charities." … [Read more...]
In Catholic Digest: 12 Questions to Ask before Giving Money to Charity
Many thanks to Kiernan O'Connor of the Donor Motivation Program of Houston for a great interview. It incorporates advice that will be equally useful for large investors and for widow's mite types, and also includes some investing tips.I don't think the article is available online yet at Catholic Digest, but I did want to highlight a few of the charities that I recommended in the article: Save a Family Plan A top notch international NGO run by Catholics, serving poor Indian families of … [Read more...]


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|By PlatformPCPS3Xbox 360Wii U3DSPS VitaAndroidiPhoneiPadOther HardwareEditor's Choiceby Author
|By LatestThe best and worst s : May Returns Kalimba
8.0Guilty Gear Xrd -SIGN-
9.0Lara Croft and the Temple of...
6.0Kingdom Hearts 2.5 HD ReMIX
9.0Destiny: The Dark Below
6.5Review in Progress: Destiny: The...
3.0The Talos Principle
8.0Peggle Blast
2.0Secret Ponchos
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|By GenreActionAdventureFightersFree-to-playMMOMusicPlatformShootersSportsRPGStrategyMore genres
Croteam's sharp departure from running and gunning The Talos Principle is out on Steam today. I think it is great, and I am not alone. It is probably the best puzzle game to come out this year, and it is certainly the game t...
|Darren Nakamura
2:00 PM on 12.08.2014
LIVE! Absinthe vs. The Talos Principle: A Most Distinguished Stream
You guys might recall (we sure as hell don't) a month or so ago, Devolver Digital sent me and Bill an early build of Titan Souls and a couple large bottles of some sort of ale made by wizards or monks or something. Bill and I...
Review: The Talos Principle
by Darren Nakamura
While playing The Talos Principle, much of my time was spent sitting at my desk, chin in hand, deep in thought. I can only imagine the puzzled look on my face as I considered options, ran scenarios in my head, and generally did a lot more thinking than most games ask of players.
The Talos Principle consists of two largely separate interactions: physics-based puzzles and philosophical discussion. The real strength of the title is that while each could reasonably exist without the other, both elicit the above response in equal measure. The demand that the player really think is the thread that ties the whole game together.view full story + comments
The Talos Principle makes me feel smart and dumb
by Darren Nakamura
Back at E3 2014, I got a brief chance to get my hands on The Talos Principle while talking to one of its writers Tom Jubert (FTL: Faster Than Light, The Swapper). In the presentation, Jubert explained the intended approach to discussing philosophy with the player, but I was only able to get through a few puzzles.
With its retail release scheduled in less than a month, I have had some more time to spend with Croteam's first-person puzzler. So far, it has made me think hard, both about the solutions to puzzles and its thoughts about sapience.view full story + comments
11:30 AM on 11.07.2014
Devolver Digital releases public test for The Talos Principle
From the shy, but devilishly good-looking people at Devolver Digital and Croteam's department of theoretical philosophy comes a brave new thought experiment in games marketing. Rather than relying on the tried-and-true ...
1:00 PM on 10.18.2014
Devolver Digital and Croteam release free puzzler mini-game
Croteam, the independent development studio behind the Serious Sam games and debonair indie publisher Devolver Digital have recently released a free mini-game prelude to their upcoming philosophical first-person puzzle gam...
10:15 AM on 07.08.2014
Serious Sam devs ditching guns for a mysterious puzzler (with lasers)
The Talos Principle was revealed at E3, from which Darren Nakamura got a nice preview of the game. The latest from Croteam (Serious Sam) seems more Portal than shotgun eviscerator and will be available this yea...
The Talos Principle explores philosophy and lasers
by Darren Nakamura
Nestled in a parking lot across the street from the convention center in Los Angeles was Devolver Digital's phalanx of air conditioned campers. The publisher had a good mixture of highly anticipated titles like Hotline Miami 2 and Broforce, and more recently announced titles. The Talos Principle is one such game, and as usual, Devolver knows how to curate good content.
Though it is being developed by Croteam, which is probably best known for its over-the-top first-person shooter series Serious Sam, The Talos Principle has more in common with Portal. Its first-person puzzle platforming is not built off the most mindblowing ideas, but it is only part of the focus. The rest is on a deeply philosophical narrative, courtesy of Tom Jubert, who delivered a fantastic story in my favorite game from 2013: The Swapper.
Suffice it to say, I left the camper with fairly high expectations for this.view full story + comments
1:30 PM on 04.30.2014
Serious Sam Classics: Revolution out now on Early Access
It's time to get serious. Or stoic. Actually, if Serious Sam is your thing, you might even want to get excited. A team of fans (with Croteam's blessing, no less) has launched Serious Sam Classics: Revolution on Steam, an ite...
9:14 AM on 11.06.2012
Croteam dev hates Windows 8, calls it a 'walled garden'
A number of game developers have already shared their less-than-positive views on Windows 8, slamming Microsoft's new interest in ruling the PC gaming market through proprietary services. Croteam's chief technical offer ...
7:30 PM on 10.17.2012
Serious Sam 3: Jewel of the Nile DLC and franchise sale
If you were salivating at the chance to play more Serious Sam 3, then your wait is over. The Jewel of the Nile DLC is now out for Croteam's old-school FPS, consisting of three new levels as the titular hero travels to the&nbs...
12:30 PM on 10.12.2012
Rich Knuckles announces Serious Sam 3: BFE coming to XBLA
That's right, Serious Sam 3: BFE is finally making its way to Xbox Live Arcade, and it's launching in less than a week, no less. The single-player and co-op parts will be available for 1200 Microsoft Points, while the multip...
7:30 PM on 07.24.2012
A Linux version is next for Serious Sam 3: BFE
The latest update on Valve's interest in bringing Left 4 Dead 2 and Steam over to Ubuntu was a spot of bright news for Linux users, and there's more where that came from. Croteam and Devolver Digital have announced that Serio...
5:30 PM on 05.16.2012
Live show: Serious Sam giveaway on Mash Tactics
It's about to get all super serious on Mash Tactics today! King Foom is going balls to the wall in Serious Sam 3: BFE multiplayer. On top of that, we have a bunch of codes for the Serious Sam Complete Pack on Steam, courtesy ...
5:00 PM on 12.07.2011
Serious Sam 3 DRM = Immortal Pink Scorpion
Despite Serious Sam 3 promising to fight piracy simply by being an awesome game, it turns out that developer Croteam has snuck some DRM in there. Fortunately, it's the best kind of DRM -- the kind that only affects illegal c...
Review: Serious Sam 3: BFE
by Jim Sterling
As games become increasingly complex and try to explore new, innovative ideas, the market is ripe for a game that takes us back to square one. Despite our lofty ideals and desire to treat videogames as art, there's still a base hunger for reckless destruction and wanton violence, the kind that has permeated our entertainment since time immemorial.
Enter Serious Sam 3: BFE, a game that saw an opportunity and took it. In a generation full of military shooters and quirky gimmicks, "Serious" Sam Stone knows exactly what you need, and is more than happy to deliver.view full story + comments


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In the age of Botox and anti-aging cosmeceuticals, handheld dermatological devices for at-home use offer consumers alternatives to invasive surgeries and spa treatments. Learn more about this new category of competition for your spa.
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Photo by Eliza Barclay
Tony Geraci, food service director for Baltimore City Public Schools, is an emerging champion of healthy school food, along with Alice Waters, Anne Cooper and Michelle Obama--and, as with them, the press has hungrily followed Geraci since he moved from New Hampshire to Baltimore last year to take over food service for the public school system [Curator's note: including me! But I met Geraci before he got famous].
Lately, it has seemed even hungrier, because of a decision the Baltimore school system made: the school system's 80,000 students weren't going to get any meat on Mondays.
The Meatless Mondays program was launched to reduce the cholesterol and saturated fats in the lunch offerings and introduce alternate proteins and vegetables. (It's also helped the cash-strapped school district cut some costs.) Geraci and chef/dietician Mellissa Mahoney say they don't want to promote vegetarianism, just healthy omnivorism. On Mondays, beans and cheese are the main source of protein (along with vegetables and grains) and kids don't lose out on a single gram.
The Baltimore Sun reported that the Animal Agriculture Alliance has implored citizens "shocked" by Meatless Mondays to contact the school system.
But the American Meat Institute, along with the Animal Agriculture Alliance, the Missouri Beef Council, and the editors of Pork Magazine, were unsurprisingly unhappy with the plan, and went to the press themselves.
Janet Riley, of the American Meat Institute, went on Lou Dobbs' show on CNN last week to chastise Baltimore for depriving its students of key nutrients: protein. Her boss, the group's CEO, has also written a public letter to Baltimore's City Schools CEO Andrés Alonso, noting he was "disturbed" by the initiative and that "meat and poultry may be the only significant source of protein" in Baltimore kids' diets. (The claim is of course groundless, as the Food Channel's Marion Nestle explained to the author of this blog post, which also gives a roundup of some of the press coverage of Meatless Mondays.) Janet Riley gave Dobbs a figure: 75 percent of American children, she said, are not getting enough protein. I was visiting Baltimore the day of the Dobbs taping, and asked her the following day by phone share the source of the number. She promised to email it, but never did.
When I asked Riley her thoughts about the problem of childhood obesity and other health issues, she replied: "Meat is associated with weight control. It's not the number one source of fat in their diet." She also invoked her own two sons to emphasize that kids require animal protein in their diets. "Meat is what keeps them satisfied and out of the pantry," she told me.
In an editorial published earlier this month, Pork Magazine wrote, "The Baltimore school officials have taken it upon themselves to relieve dietitians and nutritionists of part of their duties, at least for the first day of the school week." Funnily enough, it was the school district's only dietician, Mahoney, who conceived the program.
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LC-A+ / KrabThis photo was shot on film. Taken by emkei with a Lomo LC-A+ (available in our Online Shop) loaded with Kodak Elitechrome EBX film (available in our Online Shop) in Križovany nad Dudváhom, Slovakia. These tags describe this photo: lc-a, lomo lc-a+, kodak elitechrome 100, kodak, elitechrome, 35mm, xpro, x-pro, tetenal c41 kit, tetenal, c41, home processing, underwater, and krab. Date: 2011-08. Time: Afternoon. This photo can also be found in the album lc-a+ / elitechrome / xpro.
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Uhm...what's going on there? ;)
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Elon Musk described the new Tesla Model D as a digital vehicle compared to conventional ICE autos which are analog mechanical machines. The Model D is an iterative upgrade of the Model S, but it presents two significant feature sets that demonstrate how the auto world is moving from the analog to the digital age… Keep reading →
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Natural gas supply negotiations between Russia's Gazprom and Ukraine's Nagtogaz appear to be inching closer to a deal. In fact, the two sides have agreed on a price of $385 per thousand cubic meters, but payment details now appear to be a sticking point. "If the Ukrainians have the money, then the documents will be signed. If not,… Keep reading →
Energy News Roundup: Total CEO Dies in Plane Crash, Amsterdam Airport Tesla Taxis & MPs Pension Fund Fossil Fuel DivestmentBy Jared Anderson
Christophe de Margerie, CEO of major French oil company Total, was killed Monday night when his corporate jet crashed into a snow removal vehicle on the runway of an airport near Moscow. The company reportedly has no succession plant in place, but has strong corporate governance led by a long-standing board of directors. "Barclays France… Keep reading →
The Case for Electric Vehicles, Part 2: EV CostsBy Edward Dodge
Electric Vehicles today are considered to be more expensive to purchase than their Internal Combustion Engine counterparts. But the purchase price of EV's versus ICE vehicles tells an incomplete story about the comparative costs. While none of the EV's on the market today are cheap, they are competitively priced for their class of vehicle. The… Keep reading →
The Case for Electric Vehicles, Part 1: The Driving ExperienceBy Edward Dodge
I recently had the opportunity to test drive the Tesla Model S P85, the high-performance version of the highly acclaimed all-electric luxury sedan. Like many drivers of the Model S, I was thoroughly impressed by the performance of this machine and after examining the engineering I am increasingly convinced that electric vehicles (EVs) are the… Keep reading →
Energy News Roundup: Major Siemens Acquisition, Solar City Batteries for Everyone! And $1.2B NJ Infrastructure UpgradeBy Jared Anderson
Siemens is acquiring gas equipment manufacturer Dresser-Rand for $7.6 billion dollars in a move meant to help the German conglomerate capitalize on the US energy boom. Earlier this year Siemens bought "most" of Rolls-Royce's civil energy operation for $1.3 billion. The acquisitions are also likely motivated by a desire to remain competitive with rival GE, which… Keep reading →
News broke on Wednesday that Nevada had apparently won the five-state competition to land Tesla Motors' vaunted Gigafactory. A boost in manufacturing prestige and 6,500 jobs are expected to result – but is it possible this giant battery plant of the future could turn out to be a white elephant? OK, Lux Research didn't go… Keep reading →
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Q: How fast can I go? A: How much do you want to spend? It seems like Renovo Motors, the just-unstealthed EV builder, wants to build really fast battery-powered cars. Like, 0-to-60-in-3.4-seconds fast. Elon Musk of Tesla certainly wants to build really fast performance cars. But Musk also wants to build a mass-market EV, move the world to solar power… Keep reading →
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It's not quite full-steam ahead on a Reno "Gigafactory" for Tesla – but the electric car company did confirm that it has pushed around a lot of Nevada dirt, while also keeping its options open in Arizona, California, New Mexico and Texas. This revelation came in the company's second quarter 2014 shareholder letter [PDF], issued… Keep reading →


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Families 2-gether
member for 4 years, 4 months, 3 days
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Shill, Dantzler, Clay, Clayton, Boone, Gavin, Byrd,Hayes, Vogeli, Schnetzler, Gould,Henderson, Camp,Schroeder, Barnes, Westbrook, McInnis, Anderson,Green
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J. James Sandy
RE: 105804815 Green Martha A
That's OK...are you related on the James side or Green side? If on the James side do you have any info or know where Joseph Berry James (her brother)and Mary Ann Ridge James or her father Joseph James and Rachel Berry James might be buried?? Also would you share your Green family genealogy with me? You may contact me thru my personal e-mail address. Thank you for responding.
Added by
J. James Sandy
on Jan 20, 2014 1:19 PM
J. James Sandy
105804815 Green Martha A
If this isn't your family, would you please transfer to me? This is a great-aunt of my fathers. Thanks.
Added by
J. James Sandy
on Sep 18, 2013 6:20 PM
J. James Sandy
Records Added Feb 2013
Thank you for the info at Harrison Cemetery, Franklin Co. I'm from WV and made a trip to Tenn looking for family at various cemeteries. On the day I was at Harrison it was a rainy nasty day and I didn't stay as long as I wanted. The James & Martha Green are family. She was the aunt of Lawrence James (who's marker I did find) and grand aunt of my father. Looking forward to finding more "family" at the cemeteries in Franklin & Grundy Co.
Added by
J. James Sandy
on Mar 11, 2013 7:18 PM
RE: Vogeli
I just completed transferring the Vogeli memorials to you.
I also did the 2 young boys as their names are on the same marker.
I'm assuming they are Henry & Elizabeth's sons, but don't know for sure.
If you know you could link them to their parents.
Added by
on May 17, 2012 5:19 AM
RE: Vogeli
I just happened to be in the cemetery looking for markers for a friend and started taking pictures of memorials that captured my attention.
Are you related? I am not related to the Vogeli's and would be more then happy to transfer their memorials to you.
Added by
on May 08, 2012 9:06 PM
Sandy Burt Gaddis
Shill Family
Hi Sherri,
Congratulations on your DAR membership. Who did you join on?
Now you can join the UDC Organization too on your great great great grandfather John Alexander SHILL. He served in the Gid Nelson Company in Alabama.
He is buried in the Forest Hill Cemetery in Birmingham, AL. John's memorial is on Find A Grave, ID #83395333.
Wish you could come to reunion. I heard that Patrick was out of hospital. Pray he recuperates soon.
Love, Sandy & Ben
Added by
Sandy Burt Gaddis
on Apr 29, 2012 10:57 AM
Sandy Burt Gaddis
yes, I am a DAR member but I'm not related by Shill/Gaddis I only married into family (Shill/Gaddis) Do you still need my DAR #.
I don't think Mary Ruth is a DAR member but her mother, Ann Shill Mayerhoff was a member. I think she got membership on the Clayton side but Mary Ruth can tell you better than I.
Added by
Sandy Burt Gaddis
on Aug 18, 2011 11:37 AM
RE: Amazing
Thank you very much. The compliment is appreciated.
Added by
on Aug 15, 2011 5:00 PM
RE: James H, Hayes Perrysburg, Ohio
If you'll send me the information, I'll be happy to correct the biography or I can transfer the memorial to you and you can do it. Please let me know how you would like to handle the situation.
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on Aug 25, 2010 11:33 PM
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If your clothes are always slipping off your hangers and losing their shape, or ending up at the bottom of the wardrobe, Wenko's Hanger Strips are just what you need. Just stick one on each arm of the hanger and the knobbly silicone surface will keep them in place.Wenko Hanger Strips, pack of 20, £4.50
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Algerians have started casting their votes in presidential elections that are likely to lead to Abdelaziz Bouteflika's fourth mandate, despite wide expections of a low turnout and amid calls for a boycott with the opposition warning of rigged results.
More than 260,000 police have been deployed to protect the 50,000 polling booths opening on Thursday across Africa's largest country. Around 23 million Algerians have registered on the electoral roll as eligible voters in Algeria and abroad to choose between the six contesting candidates.Bouteflika, 77, who is seeking to extend his 15-year rule despite chronic health problems, is the firm favourite.
He has appeared only rarely on television in recent months, looking frail, after suffering a mini-stroke last year which confined him to hospital in France for three months.
His weakness was adamant as he sat on a wheel chair while casting his vote at an Algiers polling station on Thursday. Local media had rumoured that he would not be able to cast his vote in person due to his health condition.
But with opposition parties and youth activists loudly calling on Algerians to snub the poll, and many questioning his ability to rule, Bouteflika faces the risk of a damaging low turnout.His intention to seek re-election was announced in February, prompting derision from his critics.
Youth protest group
According to the Interior Ministry, turnout has already 15 percent.
Interior Minister Tayeb Belaïz said that the thusfar-reached turnout is "an increase when compared to that recorded during the 2009 election" at the same time, adding that "clues point to the participation rate will increase in later today". He added that voting is taking place under "ordinary conditions".
Algeria, which has largely escaped the massive political alterations brought about by the "Arab Spring", has witnessed sporadic election-related violence in the weeks leading up to the polls.Youth protest group Barakat (Enough), a rare public expression of the anger and frustration felt by some Algerians towards political authoritarianism, was founded just two months ago specifically to oppose the president's bid for a fourth term.Police violently dispersed a demonstration the group organised in Algiers on Wednesday and arrested some of its members.Amnesty International and Human Rights Watch have both voiced concerns about efforts by the authorities to restrict freedom of speech ahead of the vote, while Reporters Without Borders on Wednesday highlighted the difficulties faced by journalists trying to cover it.Out of the total six candidates, the president's main rival, former prime minister Ali Benflis who ran against Bouteflika in 2004 but lost heavily, said fraud will be his "main adversary" on Thursday.
Benflis warned that he would "not keep quiet" if the election is stolen.
Despite the sometimes scathing criticism levelled against him in the independent media, Bouteflika remains popular with many Algerians.
He is credited for helping to end the devastating civil war of the 1990s, and containing the social unrest that spread to Algeria in January 2011 by offering political reforms, lifting a 19-year state of emergency and raising wages.
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Recent Updates
European Economies Face an Unpredictable 2012
30 November 2011
Many of you are in the throes of budgeting for the coming year, a task made more daunting by lingering economic uncertainties. With economists hard-pressed to predict what will happen tomorrow, how is business expected to predict likely revenue and costs 12 months out?
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Suppliers and customers are all raving about services procurement. But here's the catch: It means different things to different people, so Editorial Director Subadhra Sriram decided to understand what the term meant. After chatting with various industry folks, she wrote what she learned in the Contingent... More
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Recast the Mold
28 November 2011
Revamp your budgeting process and create a stronger value proposition for your firm.
Above the Crowd
28 November 2011
Slow economy or not, a number of staffing firms still boasted substantial growth rates. Staffing Industry Analysts' 2011 list of fastest-growing staffing firms includes 42 such firms. But what are some trends among this breed?
The Price May Be Right
28 November 2011
The number of staffing industry mergers & acquisitions shrank with the recession. Buyers are now back, but whether this is a good time to sell depends on the specific deal.
People First
28 November 2011
ManpowerGroup Inc. CEO Jeffrey A. Joerres discusses why he coined the "Human Age" concept, its impact and where he sees his company and the staffing industry headed.
Power Seller
28 November 2011
Power Seller: Preposition power


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Corner Detail: Stretched canvas print with 1.5" stretcher bars and mirrored image sides. Also available with black sides, whites sides, and 5/8" stretcher bars.
Bring your artwork to life with the texture and depth of a stretched canvas print. Your image gets printed on one of our premium canvases and then stretched on a wooden frame of 1.5" x 1.5" stretcher bars (gallery wrap) or 5/8" x 5/8" stretcher bars (museum wrap). All stretched canvases ship within 3 - 4 business days and arrive "ready to hang" with pre-attached hanging wire, mounting hooks, and nails.
Stretched canvas prints look beautiful with or without frames.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality prints. All of our prints are produced on state-of-the-art, professional-grade Epson printers. We use acid-free papers and canvases with archival inks to guarantee that your prints last a lifetime without fading or loss of color.
A familiar sight in Bangalore, India; people squatting on street corners, involved in conversations and passing the time. So much is communicated through hand gestures. I placed the emphasis of the painting on these hands, not minding at all that I had only a partial view of the young man's head. This painting marks a turning point for my work and I feel that it relates more than just a conversation or a moment in time. It encapsulates a culture and a way of life.
Award-winning Artist Kate Bedell works in Watercolour and Mixed Media Collage. Her work features landscapes, gardens, flowers, nudes and landscapes. She graduated from Dun Laoghaire School of Art and Design in 1984 with a distinction in Fine Art. In 1998 she was made a member of the Irish Water Colour Society where she exhibits her paintings annually. She has also exhibited in the Royal Hibernian Academy Annual shows (1985 and 1992) and her work is part of many private collections worldwide. She took part in the Channel 4 television series "Watercolour Challenge in Ireland" in 1999 and painted Powerscourt Waterfall in Wicklow, and Joyces Tower in Sandycove. Both paintings were exhibited and sold in the Mall Galleries, London, U.K. ...
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If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that 280,699 artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
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All canvas prints ship from our production facility within three business days of your order.