text:
Jeffrey L Cummings
University of Nevada, Las Vegas, Las Vegas, Nevada, United States
Are you Jeffrey L Cummings?
Claim your profile
Total impact
Available from: Anton P Porsteinsson
Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition.
Jeffrey Cummings,
Jacobo Mintzer
Henry Brodaty
Mary Sano
Sube Banerjee
D P Devanand
Serge Gauthier
Robert Howard
Krista Lanctôt
Constantine G Lyketsos
Elaine Peskind
Anton P Porsteinsson
Edgardo Reich
Cristina Sampaio
David Steffens
Marc Wortmann
Kate Zhong
[Show abstract]
[Hide abstract]
ABSTRACT Background: Agitation is common across neuropsychiatric disorders and contributes to disability, institutionalization, and diminished quality of life for patients and their caregivers. There is no consensus definition of agitation and no widespread agreement on what elements should be included in the syndrome. The International Psychogeriatric Association formed an Agitation Definition Work Group (ADWG) to develop a provisional consensus definition of agitation in patients with cognitive disorders that can be applied in epidemiologic, non-interventional clinical, pharmacologic, non-pharmacologic interventional, and neurobiological studies. A consensus definition will facilitate communication and cross-study comparison and may have regulatory applications in drug development programs. Methods: The ADWG developed a transparent process using a combination of electronic, face-to-face, and survey-based strategies to develop a consensus based on agreement of a majority of participants. Nine-hundred twenty-eight respondents participated in the different phases of the process. Results: Agitation was defined broadly as: (1) occurring in patients with a cognitive impairment or dementia syndrome; (2) exhibiting behavior consistent with emotional distress; (3) manifesting excessive motor activity, verbal aggression, or physical aggression; and (4) evidencing behaviors that cause excess disability and are not solely attributable to another disorder (psychiatric, medical, or substance-related). A majority of the respondents rated all surveyed elements of the definition as "strongly agree" or "somewhat agree" (68-88% across elements). A majority of the respondents agreed that the definition is appropriate for clinical and research applications. Conclusions: A provisional consensus definition of agitation has been developed. This definition can be used to advance interventional and non-interventional research of agitation in patients with cognitive impairment.
International psychogeriatrics / IPA. 10/2014;
Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease.
Jagan A Pillai
Aaron Bonner-Jackson
Esteban Walker
Lyla Mourany
, Jeffrey L Cummings
[Show abstract]
[Hide abstract]
Background: There is heterogeneity in the pattern of early cognitive deficits in Alzheimer's disease (AD). However, whether the severity of initial cognitive deficits relates to different clinical trajectories of AD progression is unclear. Objective: To determine if deficits in specific cognitive domains at the initial visit relate to the rate of progression in clinical trajectories of AD dementia. Methods: 68 subjects from the National Alzheimer's Coordinating Center database who had autopsy-confirmed AD as the primary diagnosis and at least 3 serial assessments a year apart, with a Mini-Mental State Examination (MMSE) score >15 and a Clinical Dementia Rating Scale-Global (CDR-G) score ≤1 at the initial visit were included. A mixed regression model was used to examine the association between initial neuropsychological performance and rate of change on the MMSE and CDR Sum of Boxes. Results: Preservation of working memory, but not episodic memory, in the mild cognitive impairment and early dementia stages of AD relates to slower rate of functional decline. Discussion: These findings are relevant for estimating the rate of decline in AD clinical trials and in counseling patients and families. Improving working memory performance as a possible avenue to decrease the rate of functional decline in AD dementia warrants closer investigation. © 2014 S. Karger AG, Basel.
Dementia and Geriatric Cognitive Disorders 06/2014; 38(3-4):224-233.
· 2.79 Impact Factor
Available from: onlinelibrary.wiley.com
Overcoming obstacles to repurposing for neurodegenerative disease
Diana W. Shineman
John Alam
Margaret Anderson
Sandra E. Black
Aaron J. Carman
, Jeffrey L. Cummings,
Penny A. Dacks
Joel T. Dudley
Donald E. Frail
Allan Green
Rachel F. Lane
Debra Lappin
Tanya Simuni
Richard G. Stefanacci
Todd Sherer
Howard M. Fillit
[Show abstract]
[Hide abstract]
Repurposing Food and Drug Administration (FDA)-approved drugs for a new indication may offer an accelerated pathway for new treatments to patients but is also fraught with significant commercial, regulatory, and reimbursement challenges. The Alzheimer's Drug Discovery Foundation (ADDF) and the Michael J. Fox Foundation for Parkinson's Research (MJFF) convened an advisory panel in October 2013 to understand stakeholder perspectives related to repurposing FDA-approved drugs for neurodegenerative diseases. Here, we present opportunities on how philanthropy, industry, and government can begin to address these challenges, promote policy changes, and develop targeted funding strategies to accelerate the potential of FDA-approved repurposed drugs.
Annals of Clinical and Translational Neurology. 06/2014;
Available from: Luca Pani
Taking stock: A multistakeholder perspective on improving the delivery of care and the development of treatments for Alzheimer's disease.
Patrick Bradley
Ron Akehurst
Clive Ballard
Sube Banerjee
Kaj Blennow
Jennifer Bremner
Karl Broich
, Jeffrey Cummings,
Karen Dening
Bruno Dubois
, [......],
Luisa A A Muscolo
François Nicolas
Luca Pani
Louise Robinson
Paolo Siviero
Julius van Dam
Jan Van Emelen
Anders Wimo
Marc Wortmann
Lindee Goh
[Show abstract]
[Hide abstract]
Health-care stakeholders increasingly recognize that the scientific and economic challenges associated with Alzheimer's disease (AD) are simply too great for individual stakeholder groups to address solely from within their own silos. In the necessary spirit of collaboration, we present in this perspective a set of multicountry multistakeholder recommendations to improve the organization of existing AD and dementia care and the development of new treatments. In brief, the five recommendations are (1) health-care systems must make choices regarding the patient populations to be diagnosed and treated, (2) health-care systems should use an evidence-based standard of care, (3) increased collaboration between public and private institutions is needed to enhance research, (4) reimbursement end points need to be agreed on and validated, and (5) innovative business models should be used to spur the introduction of new medicines.
Alzheimer's & dementia: the journal of the Alzheimer's Association 04/2014;
· 14.48 Impact Factor
The "Alzheimer's Type" Profile of Semantic Clustering in Amnestic Mild Cognitive Impairment.
Paula M McLaughlin
Matthew J Wright
Michael Larocca
Peter T Nguyen
Edmond Teng
Liana G Apostolova
John M Ringman
Yan Zhou
, Jeffrey L Cummings,
Ellen Woo
[Show abstract]
[Hide abstract]
Impairments in learning and recall have been well established in amnestic mild cognitive impairment (aMCI). However, a relative dearth of studies has examined the profiles of memory strategy use in persons with aMCI relative to those with Alzheimer's disease (AD). Participants with aMCI, nonamnestic MCI, AD, and healthy older adults were administered the California Verbal Learning Test-II (CVLT-II). Measures of semantic clustering and recall were obtained across learning and delayed recall trials. In addition, we investigated whether deficits in semantic clustering were related to progression from healthy aging to aMCI and from aMCI to AD. The aMCI group displayed similar semantic clustering performance as the AD participants, whereas the AD group showed greater impairments on recall relative to the aMCI participants. Control participants who progressed to aMCI showed reduced semantic clustering at the short delay at baseline compared to individuals who remained diagnostically stable across follow-up visits. These findings show that the ability to engage in an effective memory strategy is compromised in aMCI, before AD has developed, suggesting that disruptions in semantic networks are an early marker of the disease. (JINS, 2014, 20, 1-11).
Journal of the International Neuropsychological Society 02/2014;
· 2.70 Impact Factor
Repackaging FDA-approved drugs for degenerative diseases: promises and challenges.
Jeffrey L Cummings,
Kate Zhong
[Show abstract]
[Hide abstract]
Repurposing refers to the therapeutic use of a drug or drug candidate for a disease other than that for which it was originally intended. Repurposing is attractive as a drug development strategy since much is known about approved agents including their drug-likeness and pharmacokinetic features, dosing, safety, tolerability, formulation and manufacturing. Time savings are also robust accounting for several years of the drug development cycle. Tissue and cell-based assays, epidemiologic information and human studies identify approved drugs that might be repurposed from use in Alzheimer's disease and other neurodegenerative disorders. The total number of compounds available for repurposing that are brain-penetrant is relatively small. Intellectual property and patent protection issues for repurposed drugs are hurdles for this approach to drug development. Repurposing may contribute importantly to development of new therapies for neurodegenerative disorders.
Expert Review of Clinical Pharmacology 02/2014;
Risk Factors for Behavioral Abnormalities in Mild Cognitive Impairment and Mild Alzheimer's Disease.
Liana G Apostolova
Li Jie Di
Erin L Duffy
Jenny Brook
David Elashoff
Chi-Hong Tseng
Lynn Fairbanks
, Jeffrey L Cummings
[Show abstract]
[Hide abstract]
Background: Behavioral symptoms are common in both mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods: We analyzed the Neuropsychiatric Inventory Questionnaire data of 3,456 MCI and 2,641 mild AD National Alzheimer's Coordinating Center database participants. Using factor analysis and logistic regression we estimated the effects of age, sex, race, education, Mini-Mental State Examination, functional impairment, marital status and family history on the presence of behavioral symptoms. We also compared the observed prevalence of behavioral symptoms between amnestic and nonamnestic MCI. Results: Four factors were identified: affective behaviors (depression, apathy and anxiety); distress/tension behaviors (irritability and agitation); impulse control behaviors (disinhibition, elation and aberrant motor behavior), and psychotic behaviors (delusions and hallucinations). Male gender was significantly associated with all factors. Younger age was associated with a higher prevalence of distress/tension, impulse control and psychotic behaviors. Being married was protective against psychotic behaviors. Lower education was associated with the presence of distress/tension behaviors. Caucasians showed a higher prevalence of affective behaviors. Functional impairment was strongly associated with all behavioral abnormalities. Amnestic MCI patients had more elation and agitation relative to nonamnestic MCI patients. Conclusions: Younger age, male gender and greater functional impairment were associated with higher overall presence of behavioral abnormalities in MCI and mild AD. Marital status, lower education and race had an effect on selected behaviors. © 2014 S. Karger AG, Basel.
Dementia and Geriatric Cognitive Disorders 01/2014; 37(5-6):315-326.
· 2.79 Impact Factor
Available from: Marc Wortmann
Taking stock: A multistakeholder perspective on improving the delivery of care and the development of treatments for Alzheimer's disease
Patrick Bradley
Ron Akehurst
Clive Ballard
Sube Banerjee
Kaj Blennow
Jennifer Bremner
Karl Broich
, Jeffrey Cummings,
Karen Dening
Bruno Dubois
, [......],
Luisa A.A. Muscolo
François Nicolas
Luca Pani
Louise Robinson
Paolo Siviero
Julius van Dam
Jan Van Emelen
Anders Wimo
Marc Wortmann
Lindee Goh
[Show abstract]
[Hide abstract]
Health-care stakeholders increasingly recognize that the scientific and economic challenges associated with Alzheimer's disease (AD) are simply too great for individual stakeholder groups to address solely from within their own silos. In the necessary spirit of collaboration, we present in this perspective a set of multicountry multistakeholder recommendations to improve the organization of existing AD and dementia care and the development of new treatments. In brief, the five recommendations are (1) health-care systems must make choices regarding the patient populations to be diagnosed and treated, (2) health-care systems should use an evidence-based standard of care, (3) increased collaboration between public and private institutions is needed to enhance research, (4) reimbursement end points need to be agreed on and validated, and (5) innovative business models should be used to spur the introduction of new medicines.
Alzheimer's & Dementia. 01/2014;
Neuropathologic correlates of trial-related instruments for Alzheimer's disease.
Jeffrey L Cummings,
John Ringman
Harry V Vinters
[Show abstract]
[Hide abstract]
To advance disease-modifying therapies, it is critical to understand the relationship between the neuropathological changes of Alzheimer's Disease (AD) and the clinical measures used in therapeutic trials. We reviewed neuropathologically proven cases of AD from the National Alzheimer's Coordinating Center (NACC) and examined correlations between neuropathological changes and clinical-trial related instruments collected as part of the Uniform Dataset (UDS). We explored the relationships between neurofibrillary tangles, neuritic plaques, and total pathology burden with immediate and delayed recall, Clinical Dementia Rating-Sum of Boxes, Functional Activity Questionnaire, Neuropsychiatric Inventory Questionnaire, and Mini-Mental State Examination scores. 169 patients in NACC database had appropriate neuropathological and clinical data. All instruments correlated highly with neuritic plaques, Braak staging, and total pathology. Correlation coefficients for the relationships were relatively modest, suggesting that the pathologic burden examined accounts for between 13 and 40% of the variance of each of the instruments assessed. We conclude that there is a strong correlation between clinical trial-related measures and neuropathology identified at autopsy in AD. The amount of variance explained by the pathology is limited and other factors, both disease- and measurement-related, contribute to the variability observed in clinical measurements.
American journal of neurodegenerative disease. 01/2014; 3(1):45-9.
Available from: PubMed Central
Alzheimer's disease drug-development pipeline: few candidates, frequent failures.
Jeffrey L Cummings,
Travis Morstorf
Kate Zhong
[Show abstract]
[Hide abstract]
Alzheimer's disease (AD) is increasing in frequency as the global population ages. Five drugs are approved for treatment of AD, including four cholinesterase inhibitors and an N-methyl-D-aspartate (NMDA)-receptor antagonist. We have an urgent need to find new therapies for AD.
Alzheimer's Research and Therapy 01/2014; 6(4):37.
· 4.39 Impact Factor
Available from: Sarah J. Banks
Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes.
Justin B Miller
Sarah J Banks
Gabriel C Léger
, Jeffrey L Cummings
[Show abstract]
[Hide abstract]
Progress has been made in understanding the genetics and molecular biology of frontotemporal dementia (FTD). Targets for intervention have been identified, therapies are being developed, and clinical trials are advancing. A major challenge for FTD research is that multiple underlying pathologies can be associated with heterogeneous phenotypes. The neuropsychological profiles associated with FTD spectrum disorders often include executive dysfunction, language impairments and behavioral disturbance. Behavioral variant FTD is characterized by an initial presentation of changes in personality, behavior and/or emotion, which are often difficult to objectively capture using traditional neuropsychological measures. The two principal language variants of FTD are Progressive Nonfluent Aphasia (PNFA) with predominant agrammatic/non-fluent impairments and Semantic Dementia (SD) with semantic impairments and visual agnosia. Selection of appropriate endpoints for clinical trials is critical to ensure that the measures are adequately sensitive to detect change, yet specific enough to isolate signal from noise, and acceptable to regulatory agencies. Given the anticipated potential for small effect sizes, measures must be able to identify small incremental changes over time. It is also imperative that the measures provide adequate coverage of the constructs or behaviors of interest. Selected outcome measures should be suitable for repeat administration, yet relatively robust to practice effects to ensure that observed changes reflect true signal variance and not residual effects due to repeated measurement or poor reliability. To facilitate widespread adoption as an endpoint, measures should be readily accessible. We provide several examples of potential global, composite, and individual cognitive measures, as well as behavioral measures promising for FTD trials. Development and application of appropriate trial outcomes is critically important to success in advancing new treatments for FTD patients.
Translational neurodegeneration. 01/2014; 3:12.
Available from: Agneta Nordberg
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
B. Dubois
H. H. Feldman
C. Jacova
H. Hampel
J. L. Molinuevo
K. Blennow
S. T. DeKosky
S. Gauthier
D. Selkoe
R. Bateman
, [......],
S. Salloway
M. Sarazin
S. Epelbaum
L. C. de Souza
B. Vellas
P. J. Visser
L. Schneider
Y. Stern
P. Scheltens
, J. L. Cummings
[Show abstract]
[Hide abstract]
In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD.
Lancet Neurol. 01/2014; 13(6):614-29.
Available from: Anne Corbett
Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial.
Jeffrey Cummings,
Stuart Isaacson
Roger Mills
Hilde Williams
Kathy Chi-Burris
Anne Corbett
Rohit Dhall
Clive Ballard
[Show abstract]
[Hide abstract]
Parkinson's disease psychosis, which includes hallucinations and delusions, is frequent and debilitating in people with Parkinson's disease. We aimed to assess safety and efficacy of pimavanserin, a selective serotonin 5-HT2A inverse agonist, in this population. In our 6 week, randomised, double-blind, placebo-controlled study, we enrolled adults (aged ≥40 years) with Parkinson's disease psychosis. Antipsychotic treatments were not permitted during the study, but controlled antiparkinsonian medication or deep brain stimulation was allowed. Eligible participants entered a 2 week non-pharmacological lead-in phase to limit the placebo response, after which they were randomly allocated (1:1) to receive pimavanserin 40 mg per day or matched placebo. The primary outcome was antipsychotic benefit as assessed by central, independent raters with the Parkinson's disease-adapted scale for assessment of positive symptoms (SAPS-PD) in all patients who received at least one dose of study drug and had a SAPS assessment at baseline and at least one follow-up. We assessed safety and tolerability in all patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov, number NCT01174004. Between Aug 11, 2010, and Aug 29, 2012, we randomly allocated 199 patients to treatment groups. For 90 recipients of placebo and 95 recipients of pimavanserin included in the primary analysis, pimavanserin was associated with a -5·79 decrease in SAPS-PD scores compared with -2·73 for placebo (difference -3·06, 95% CI -4·91 to -1·20; p=0·001; Cohen's d 0·50). Ten patients in the pimavanserin group discontinued because of an adverse event (four due to psychotic disorder or hallucination within 10 days of start of the study drug) compared with two in the placebo group. Overall, pimavanserin was well tolerated with no significant safety concerns or worsening of motor function. Pimavanserin may benefit patients with Parkinson's disease psychosis for whom few other treatment options exist. The trial design used in this study to manage placebo response could have applicability to other studies in neuropsychiatric disease. ACADIA Pharmaceuticals.
The Lancet 10/2013;
· 39.21 Impact Factor
Available from: nature.com
Biomarker-Driven Therapeutic Management of Alzheimer's Disease:Establishing the Foundations.
Jeffrey Cummings,
Kate Zhong
[Show abstract]
[Hide abstract]
Biomarkers are characteristics that are objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Amyloid measures become abnormal early in the disease process and have only weak correlations with disease progression and cognitive decline; CSF tau, brain atrophy, and reduced cortical metabolism correlate with cognitive measures and disease progression. Combinations of biomarkers have higher correlations and are better predictors of future decline than single biomarkers. Current biomarkers do not account for all of the variance of AD; a more complete repertoire of biomarkers that more comprehensively assay the disease process is needed.Clinical Pharmacology & Therapeutics (2013); Accepted article preview online 8 October 2013; doi:10.1038/clpt.2013.205.
Clinical Pharmacology & Therapeutics 10/2013;
· 6.85 Impact Factor
Available from: Brian Appleby
Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications.
Brian S Appleby
, Jeffrey L Cummings
[Show abstract]
[Hide abstract]
Alzheimer's disease (AD) is the most common cause of dementia and a major cause of morbidity and mortality. The greatest risk factor for AD is age and as many countries are experiencing an aging population, the expected rise in AD threatens to have serious medical and socioeconomic impact in the coming decades. The only approved medications for AD are symptomatic and there are no currently available disease modifying treatments. Hence, a disease modifying treatment is desperately needed for AD not only for proper care and management of affected patients, but also to reduce society socioeconomic burden. Developing novel compounds for any indication is a time, effort, and money consuming endeavor and most treatments never make it to market. Other research and development strategies are needed, especially for the treatment of AD. We provide a review of the current literature in assessing possibilities of repurposing medications currently used for non-AD indications. Many different compounds from many different pharmacological classes have already been studied in an AD context. We provide a pragmatic drug repurposing score for each of these compounds based on type of studies conducted, number of possible mechanisms of action, efficacy in AD and other neurodegenerative disease studies, tolerability profile, and their ability to cross the blood brain barrier. The current data suggest several compounds worthy of further study as treatments for AD. Compounds with the highest scores include lithium, minocycline, exenatide, valproic acid, methylene blue, and nicotine.
Current topics in medicinal chemistry 09/2013;
· 4.47 Impact Factor
Efficacy of Higher Dose 13.3 mg/24 h Rivastigmine Patch on Instrumental Activities of Daily Living in Patients with Mild-to-Moderate Alzheimer's Disease.
George Grossberg
, Jeffrey Cummings,
Lutz Frölich
Giuseppe Bellelli
José L Molinuevo
Tillmann Krahnke
Christine Strohmaier
[Show abstract]
[Hide abstract]
Background: Stabilizing/reducing decline in the ability to perform activities of daily living (ADLs) is important in management of Alzheimer's disease (AD). Methods: Post hoc analysis of OPtimizing Transdermal Exelon In Mild-to-moderate Alzheimer's disease (OPTIMA), a double-blind trial comparing 13.3 and 9.5 mg/24 h rivastigmine patch in patients with AD demonstrating functional and cognitive decline with 9.5 mg/24 h patch. Efficacy on Alzheimer's disease Cooperative Study-instrumental ADL (ADCS-IADL) items, higher level function (HLF), and autonomy factors was assessed. Results: The ADCS-IADL, HLF, and autonomy factors favored 13.3 mg/24 h patch at all time points, reaching significance from weeks 16 to 48, 24 to 48, and 32 to 48, respectively. Higher dose patch demonstrated significantly greater efficacy on 10 of 17 ADCS-IADL items at 1 or more time points (P < .05 vs 9.5 mg/24 h patch). More adverse events were observed with higher dose patch; study discontinuations were similar between the doses. Conclusions: Greater efficacy of 13.3 versus 9.5 mg/24 h patch on ADL, including autonomy and HLF factors, supports this additional dosing option to prolong patients' independence.
American Journal of Alzheimer s Disease and Other Dementias 09/2013; 28(6):583-91.
· 1.52 Impact Factor
The Cleveland Clinic Lou Ruvo Center for Brain Health: Keeping Memory Alive.
Jeffrey Cummings,
Kate Zhong
Charles Bernick
[Show abstract]
[Hide abstract]
The Cleveland Clinic Lou Ruvo Center for Brain Health (LRCBH) is a unique clinical and translational research enterprise that stems from the passion of Larry Ruvo to honor his father, Lou, a victim of Alzheimer's disease (AD). To attract national attention to AD, Mr. Ruvo convinced architect Frank Gehry to construct the remarkable building complex of the LRCBH in Las Vegas, Nevada. Cleveland Clinic assumed responsibility for running the clinical and research aspects of the LRCBH. The care provided in this novel architectural setting is innovative and emphasizes patients first, care with integration of caregiver programs, and clinical research opportunities. Standardization of care, outcomes measures, and process metrics provide a platform for assessing, studying, and exporting best practices in cognitive care. Clinical trials empower patients to help solve the diseases that afflict them. The combination of a passionate founder, dramatic architecture, clinical excellence, integrated care partner programs, and commitment to development of next generation treatments makes the LRCBH a unique model of integrated care and research.
Journal of Alzheimer's disease: JAD 08/2013;
· 4.17 Impact Factor
Subscale Validation of the Neuropsychiatric Inventory Questionnaire: Comparison of Alzheimer's Disease Neuroimaging Initiative and National Alzheimer's Coordinating Center Cohorts
Paula T. Trzepacz
Andrew Saykin
Peng Yu
Phani Bhamditipati
Jia Sun
Ellen B. Dennehy
Brian Willis
, Jeffrey L. Cummings
[Show abstract]
[Hide abstract]
Objective Neuropsychiatric symptoms are prevalent in mild cognitive impairment (MCI) and Alzheimer disease (AD) and commonly measured using the Neuropsychiatric Inventory (NPI). Based on existing exploratory literature, we report preliminary validation of three NPI Questionnaire (NPI-Q-10) subscales that measure clinically meaningful symptom clusters. Methods Cross-sectional results for three subscales (NPI-Q-4-Frontal, NPI-Q-4-Agitation/Aggression, NPI-Q-3-Mood) in amnestic MCI and AD dementia cases from the National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Neuroimaging Initiative (ADNI) databases were analyzed using confirmatory unrotated principal component analysis. Results ADNI contributed 103 MCI, 90 MCI converters, and 112 AD dementia cases, whereas NACC contributed 1,042 MCI, 763 MCI converters, and 3,048 AD dementia cases. NACC had higher baseline mean age (75.7 versus 74.6), and more impaired mean scores (at month 24) on Mini-Mental State Exam (19.5 versus 22.4) and NPI-Q-10 (5.0 versus 4.3), and all NPI-Q subscales than ADNI. Medians were not different between cohorts for NPI-Q-4-Agitation/Aggression, and NPI-Q-3-Mood, however. Each item on all scales/subscales contributed variance in principal component analysis Pareto plots. All items in Factor (F) 1 for each scale/subscale projected in a positive direction on biplots (revealing coherence), whereas F2 and F3 items showed more spatial separation (revealing independence). There were remarkable similarities between cohorts for factor loadings and spatial patterns of item projections, although factor item identities varied somewhat, especially beyond F1. Conclusion The similar pattern of results across two cohorts support validity of these subscales, which are worthy of further psychometric evaluation in MCI and AD patients and preliminary application in clinical settings.
The American Journal of Geriatric Psychiatry. 07/2013; 21(7):607–622.
Available from: link.springer.com
Evaluating the cognitive effects of donepezil 23 mg/d in moderate and severe Alzheimer's disease: analysis of effects of baseline features on treatment response.
Marwan Sabbagh
, Jeffrey Cummings,
Daniel Christensen
Rachelle Doody
Martin Farlow
Liang Liu
Joan Mackell
Randi Fain
[Show abstract]
[Hide abstract]
BACKGROUND: Treatment of Alzheimer's disease with acetylcholinesterase inhibitors can result in symptomatic benefits, but patients often show variable responses. The objective of this post hoc analysis was to investigate relationships between easily identifiable baseline characteristics/demographics and cognitive response in patients treated with either donepezil 23 mg/d or 10 mg/d and to identify factors potentially influencing response. METHODS: A post hoc analysis was conducted using data from a large, 24-week, randomized, double-blind, international study enrolling patients with moderate to severe Alzheimer's disease (baseline Mini-Mental State Examination [MMSE], 0-20) (NCT 00478205). Cognitive changes in subgroups of patients based on selected baseline and demographic characteristics were compared using the least squares mean changes in Severe Impairment Battery scores at Week 24. Univariate and multivariate analyses were also performed. RESULTS: Donepezil 23 mg/d provided statistically significant incremental cognitive benefits over donepezil 10 mg/d irrespective of baseline functional severity, measured by scores on the Alzheimer's Disease Cooperative Study-Activities of Daily Living-severe version (P < 0.05). When patients were categorized by baseline cognitive severity (MMSE score), significant benefits of donepezil 23 mg/d over 10 mg/d were seen in both subgroups when based on MMSE scores of 0-9 versus 10-20 (P < 0.02 and P < 0.01, respectively), and in the more severe subgroup when based on MMSE scores of 0-16 versus 17-20 (P < 0.0001 and P > 0.05). Statistically significant incremental cognitive benefits of donepezil 23 mg/d over 10 mg/d were also observed regardless of age, gender, weight, or prestudy donepezil 10 mg/d treatment duration (P < 0.05). In the multivariate analysis, the only significant interaction was between treatment and baseline MMSE score. CONCLUSIONS: The cognitive benefits of donepezil 23 mg/d over 10 mg/d were achieved regardless of the patient's age, gender, weight, duration of prior donepezil 10 mg/d, and functional severity. The influence of baseline cognitive severity on response seemed to be dependent on the level of impairment, with cognitive benefits of donepezil 23 mg/d over 10 mg/d most apparent in those patients at a more advanced stage of disease. These data may be useful in helping practicing physicians make informed decisions for their patients with advanced Alzheimer's disease.
BMC Geriatrics 06/2013; 13(1):56.
· 2.34 Impact Factor
International work group criteria for the diagnosis of Alzheimer disease.
Jeffrey L Cummings,
Bruno Dubois
José L Molinuevo
Philip Scheltens
[Show abstract]
[Hide abstract]
Alzheimer-type biomarker changes are identifiable in asymptomatic and mildly symptomatic predementia phases of Alzheimer disease (AD) and AD dementia. The International Work Group (IWG) guidelines for diagnosis identify a unified spectrum of 3 phases. The classic clinical feature that indicates AD is an episodic memory defect of the amnestic type. IWG criteria require biomarker support for the diagnoses of AD at any clinical stage. Pathophysiologic and topographic biomarkers are recognized. These criteria are proposed to allow highly specific diagnosis of AD and assist in identifying patients for clinical trials of AD-related treatments and other types of AD research.
The Medical clinics of North America 05/2013; 97(3):363-8.
· 2.18 Impact Factor
Publication Stats
Total Impact Points
Top co-authors
View all
Paul Thompson
University of Southern California
Remove suggestion
Liana G Apostolova
University of California, Los Angeles
Remove suggestion
Lynn A Fairbanks
University of California, Los Angeles
Remove suggestion
Mario F Mendez
University of California, Los Angeles
Remove suggestion
Luis Daniel Medina
San Diego State University
Remove suggestion
Top Journals
JAMA Neurology
Journal of Neuropsychiatry
Alzheimer's and Dementia
Dementia and Geriatric Cognitive Disorders
University of Nevada, Las Vegas
Department of Psychology
Las Vegas, Nevada, United States
Cleveland Clinic
Cleveland, Ohio, United States
Alpert Medical School - Brown University
Department of Psychiatry and Human Behavior
Providence, Rhode Island, United States
University of California, San Francisco
Department of Neurology
San Francisco, California, United States
Rancho Los Amigos Rehabilitation Center
Downey, California, United States
University of California, Irvine
Department of Neurology
Irvine, CA, United States
Banner Sun Health Research Institute
Sun City, Arizona, United States
Department of Neurology
Copenhagen, Capital Region, Denmark
University of California, Los Angeles
• Department of Neurology
• Department of Medicine
• Department of Molecular and Medical Pharmacology
• Department of Psychiatry and Biobehavioural Sciences
Los Angeles, CA, United States
Pierre and Marie Curie University - Paris 6
Lutetia Parisorum, Île-de-France, France
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Torrance, California, United States
Karolinska Institutet
Solna, Stockholm, Sweden
Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
Lutetia Parisorum, Île-de-France, France
University of British Columbia - Vancouver
Division of Neurology
Vancouver, British Columbia, Canada
Stavanger University Hospital
Stavenger, Rogaland, Norway
National Yang Ming University
T'ai-pei, Taipei, Taiwan
University of Southern California
Department of Neurology
Los Angeles, California, United States
Autonomous University of Barcelona
Cerdanyola del Vallès, Catalonia, Spain
University of Iowa
Department of Psychiatry
Iowa City, IA, United States
Mayo Foundation for Medical Education and Research
Department of Neurology
Scottsdale, AZ, United States
Baylor College of Medicine
Department of Neurology
Houston, TX, United States
Alzheimer's Drug Discovery Foundation
New York City, New York, United States
Brigham and Women's Hospital
Center for Brain Mind Medicine
Boston, MA, United States
Medical University of Graz
Gratz, Styria, Austria
Indiana University-Purdue University Indianapolis
• Department of Neurology
• Department of Pathology and Laboratory Medicine
Indianapolis, IN, United States
Icahn School of Medicine at Mount Sinai
Manhattan, New York, United States
New York University
Alzheimer's Disease Center
New York City, NY, United States
University of Washington Seattle
Department of Neurology
Seattle, WA, United States
Taipei Veterans General Hospital
Neurological Institute
Taipei, Taipei, Taiwan
Chonnam National University
Department of Psychiatry
Kwangju, Gwangju, South Korea
Providence Health and Services
Renton, Washington, United States
Newcastle University Medicine Malaysia
Bharu, Johor, Malaysia
Mahidol University
Faculty of Medicine Siriraj Hospital
Krung Thep, Bangkok, Thailand
Georgetown University
Department of Biostatistics, Bioinformatics, and Biomathematics
Washington, Washington, D.C., United States
Washington University in St. Louis
Department of Neurology
San Luis, Missouri, United States
University of Pittsburgh
Department of Psychiatry
Pittsburgh, PA, United States
Pacific Neuropsychiatric Institute
Seattle, Washington, United States
Children's Hospital Los Angeles
DIvision of Neurology
Los Angeles, California, United States
Dokuz Eylul University
Faculty of Medicine
İzmir, Izmir, Turkey
University of Arkansas for Medical Sciences
Department of Psychiatry
Little Rock, AR, United States
Cornell University
Department of Psychiatry
Ithaca, NY, United States
Harbor-UCLA Medical Center
Department of Pediatrics
Torrance, California, United States
Istituto di Cura e Cura a Carattere Scientifico Basilicata
Rionero in Vulture, Basilicate, Italy
London Research Institute
Londinium, England, United Kingdom
Butler Hospital
Providence, Rhode Island, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Emory University
Department of Neurology
Atlanta, GA, United States
The Ottawa Hospital
Department of Psychiatry
Ottawa, Ontario, Canada
University of Ottawa
Department of Psychiatry
Ottawa, Ontario, Canada
Spokane VA Medical Center
Spokane, Washington, United States
Browse more researchers
© 2014 researchgate.net. All rights reserved.
About us
Contact us
Already a member?
Log in
Log in
Forgot password?
Keep me logged in
Sign Up »
ResearchGate is the professional network for scientists and researchers. Join today, it's free!


text:
Some of our local leaders are sounding off about the NRA's call for armed security inside schools. NRA CEO Wayne LaPierre's remarks drew quick reaction from lawmakers.
Click here to read the full story.
Updated: 12/20/2014 9:29:13 AM
Updated: 12/20/2014 5:29:00 PM
Updated: 12/20/2014 11:52:37 AM
Updated: 12/19/2014 6:38:00 PM

subset: commoncrawl


text:
11227 Players currently online!
Man vs. Machine - good luck!
Turn-based games at any time!
Vote for the best move to win!
Do you have what it takes?
Sharpen your tactical vision!
Get advice and game insights!
Learn from top players & pros!
View millions of master games!
Your virtual chess coach!
Perfect your opening moves!
Test your skills vs. computer!
Find the right private coach!
Can you solve it each day?
Bring it all together!
Beginners, start here!
Make friends & play team games!
News from the world of chess!
Search all Chess.com members!
Find local clubs & events!
Who's the best of your friends?
Read what members are saying!
nice one
why d4 is better than e4
by kleelof a few minutes ago
12/24/2014 - Let's Do It Again, Mate in 3
by Vicentin084 a few minutes ago
Beware! Low stats does not equal lack of ability!
by Robert0905 4 minutes ago
Slav Defense
by Robert0905 6 minutes ago
Colorado-Counter Gambit with either 1.e4 Nc6 2.d4 f5 or 1.e4 Nc6 2.Nf3 f5
by lolurspammed 8 minutes ago
Isn't disabling premove cheating?
by skakmadurinn 8 minutes ago
Minimum no. of moves for a stalemate in chess?
by phreshnez 8 minutes ago
ღ OFFICIAL 2014 Chess.com Awards ღ
by Syd_Arthur 9 minutes ago
Help! Is Knight + f + h pawn vs Bishop a draw?
by Equiv 11 minutes ago
Computer analysis lowers my self esteem
by kleelof 15 minutes ago
Home |
Why Join | Chess Topics |
About |
FAQs |
Help & Support |
Site Map
Privacy Policy |
Legal |
© 2014 Chess.com
• Chess - English
We are working hard to make Chess.com available in over 70 languages. Check back over the year as we develop the technology to add more, and we will try our best to notify you when your language is ready for translating!


text:
For new questions please post at magento.stackexchange.com, the community-run support site for the Magento community. We will be providing updates on the new forum solution soon. For questions or concerns please email firstname.lastname@example.com.
Is there anyone out there? I would like to get to know English speaking Macedonian Magento specialists.
Hi! Greetings from Macedonia.
Although I wouldn't call myself a specialist yet, I have recently tried Magento and I must say it is one great product. My only complaint is the speed, it feels somewhat heavy and sluggish - even when installed locally. Other than that, it is perfect.
Note: The Macedonian language code is mk_MK (not mc_MC) and the currency code is MKD or Den. (not MDen).
Sure… if you need anything feel free to pm me !
ifkas - 19 April 2009 10:57 AMSure… if you need anything feel free to pm me !
Sure… if you need anything feel free to pm me !
ok ,thank you!
PM me too. I know Macedonian language.
Greetings from Macedonia.
I am Magento developer, for any questions about Magento feel free to ask me.
Posicionamiento Web Madrid
Seguros Medico Sanitas
Not too much action here
something very different by the system
We'd like to hear from you! Call us, send us an email or talk to sales.
See Magento in the news, find press releases and resources for media.
Thank you for subscribingPlease check your email for a confirmation.


text:
December 24-26, 2014
Aid agencies are required to conform to stringent project reporting requirements in order to satisfy the wide range of stakeholders. Project monitoring and evaluation (M&E) information systems (IS), frequently a requirement for funding, are believed to inform the reporting process. The logical framework approach (LFA) is widely used throughout the aid agencies for project design and appraisal, and although much of the literature also promotes the use of the LFA for the purposes of M&E, it has proved inadequate. This article reviews the key limitations of the conventional LFA for M&E and proposes an extension to the LFA matrix (the "logframe") in order to facilitate its application beyond the design phase. This is achieved by adding a time dimension, more precisely defining the elements of the project MIS, and integrating other project management tools.
To enhance the ability and confidence of participants to keep projects on track towards achieving the planned outputs and expected results and effects, and learn from project implementation
By the end of the course, each participant will be able to:
- Criticize current practices for planning, monitoring and evaluation;
- Address challenges to monitor and keep project implementation on track
- Analyse and report about progress based on the program/project's results chain development
Session 1: Overview of Monitoring and Evaluation
Session 2: Result chains
Session 3: Establishing a Result-based Monitoring System
Session 4: Monitoring Information System
Session 5: Writing and Using Indicators
Session 6: Participatory Impact Monitoring
Session 7: Monitoring and Evaluation Reports
Session 8: Project Evaluation
To achieve the objectives of the training, the consultants proposed multi-methods to help participants learnt effectively. Those methodologies will be flexible to apply according to real situation of participants. The methodologies are:
- Plenary discussion, individual work, role play, café discussion, brainstorming, work in pairs, reflection and recommendation, small group work, gallery walk and presentation.
Project officers, programme coordinators, programme managers, executive directors, and relevant stakeholders.
US$160 per participants
Course Duration: 3-day
Date: December 24-26, 2014
Time: Full days
Venue: PCDT training room


text:
Television producer Norman Lear gives Starbucks chairman Howard Schultz a personal tour of his favorite room in this clip from the next episode of Iconoclasts. Each hour-long episode of the six-part series features two leading innovators from different fields who come together to discuss their passions and creative processes. Airs Thursday, November 15th @10PM on The Sundance Channel! For More info, visit: http://www.sundancechannel.com/iconoclasts/
Download the TV Guide app for iPhone, iPad and Android!


text:
Resolution: standard / high
Figure 2.
Multivariate Cox's regression hazard analysis: Association of OPN splice variant mRNA expression levels with disease-specific survival of STS patients. Cox's proportional hazard regression models were adjusted to tumor stage, tumor entity, tumor localization and the expression of OPN-a, OPN-b or OPN-c for 68 female STS patients (A.) and 52 STS patients that received radiotherapy (B.). The median values were used as cut-off points to divide the STS patients into two groups: one with high and one with low (reference group) OPN mRNA levels in tumor tissues. A. Increased expressions of OPN-a and OPN-b are strongly associated with a 3.0-fold and a 3.4-fold increased risk of tumor-related death in female STS patients, respectively (P = 0.01, CI = 1.3-6.8; P < 0.01, CI = 1.4-8.2). The STS patients with an increased OPN-c expression level have a 2.3-fold (P = 0.07, CI = 0.9-5.4) increased risk of tumor-related death. B. In STS patients that received radiotherapy, elevated mRNA expression level of OPN-b and OPN-c are significantly correlated with an increased risk of tumor-related death (RR = 10.3, P < 0.01, CI = 2.0-53.7; RR = 11.4, P < 0.01, CI = 2.2-59.3). RT patients with an increased OPN-a mRNA expression level have a 3.5-fold increased risk of tumor-related death, but this result was not significant (P = 0.07, CI = 0.9-13.0).
Hahnel et al. BMC Cancer 2012 12:131 doi:10.1186/1471-2407-12-131


text:
Most Viewed
Mehring's LA Trip
01.14.2010 //
Photos by: Jonathan Mehring
Turtle Rape Shoe
03.12.2009 //
New Nike Shoe By Lance and Craig
10.08.2008 //
Check out NIKE SB for more.
New Recruit At The Berrics
08.15.2008 //
Tyler Surrey is the latest addition to the posse….enjoy the footage here. Vox is proud to welcome Tyler Surrey to the Vox am team. His combination of smooth style and technical skating make him a strong addition to our team. Welcome to the family Tyler!
DVS Demo
08.13.2008 //
Silver Trucks Welcomes Ortiz
08.08.2008 //
Barcelona Trailer 3 Barcelona Trailer 2 Barcelona Trailer 1
Sebastopol "Sk8 Garden"
07.22.2008 //
It isn't often that we get to play in our own back yard paradise, we usually like to lay low out here & work miracles from the ASEC Bat-Cave. However, this is an event that we couldn't resist and we want you to join us in celebrating the "Grand Opening" of the brand new Sebastopol […]
Big Block Huck Jam
07.16.2008 //
HIFI teams additions
07.02.2008 //
HIFI is proud to announce the addition of Ben Gore, Zach Wagner and Nate Broussard to the team. Congrats guys!
Dallas Rockvam on Powell
05.29.2008 //
Dallas Rockvam is the new dude on the Powell program POWELLSKATEBOARDS.COMPOWELLSKATEBOARDS.COMPOWELLSKATEBOARDS.COMPOWELLSKATEBOARDS.COMPOWELLSKATEBOARDS.COM
Skate with Gusto
09.15.2007 //
which everyone can enjoy the art, live music, free drinks and most important skateboarding! The evening will be filled with fun events including a silent art auction featuring many original works from skateboarders and inspirational artist. Other attractions include, skateboard videos, raffle prizes, live musical entertainment, and drinks.


text:
The stage is set for the rematch of 2012's most closely contested congressional race, as Martha McSally has won her bid to once again challenge U.S. Rep. Ron Barber for a seat in Congress.Read More »
Tag Archives: Martha McSallyFeed Subscription
Congressional campaign finance reports show pre-primary strengths, weaknesses
Congressional pre-primary campaign finance reports filed in the past week offer a final look into the fundraising prowess of primary election candidates in three hot congressional races.Read More »
2014 primary predictions
Primary predictions submissions have closed.Read More »
McSally outraises Barber in latest quarter, but still behind overall in CD2
For the fourth quarter in a row, Martha McSally outraised U.S. Rep. Ron Barber in her bid to oust the incumbent lawmaker in Arizona's 2nd Congressional District.Read More »
Will avoiding tough questions pay off for congressional candidates?
Two congressional candidates seen as frontrunners to snag the Republican nomination in districts with vulnerable Democratic incumbents are being criticized for giving the media and constituents the silent treatment.Read More »
McSally shows fundraising strength in CD2
In Arizona's 2nd Congressional District, Republican challenger Martha McSally bested incumbent U.S. Rep. Ron Barber, a Democrat, for the second consecutive reporting cycle, proving her impressive fundraising total posted in October was no fluke.Read More »
Brewer's Jan PAC boasts $345K to help GOP candidates
New reports filed with the Federal Election Commission show Brewer was able to get nearly $42,000 in donations in the last half of 2013 to Jan PAC. That brings her annual collections up to more than $272,000.Read More »
One question dominates congressional race in southern Arizona
At a Pima County Republican Party luncheon in Tucson, voters arrive to hear a speech from the latest GOP candidate to enter the race to serve Arizona's 2nd Congressional District.Read More »
Barber commits to 2014 re-election bid
U.S. Rep. Ron Barber has made his decision: He's running for re-election in 2014.
Days after telling the Arizona Capitol Times he hadn't decided whether he would run in 2014 and saying he still had to discuss the issue with his family, Barber released a statement today pledging his full effort to keep his seat in Arizona's 2nd Congressional District.
GOP outlines strategy to unseat freshmen Arizona Democrats in Congress
The midterm congressional elections are still a year off, but the Republican Party started ratcheting up its campaign this week against three freshman Arizona Democrats it has targeted in the race.Read More »


text:
Portable Document Format (PDF) is a file format used to represent documents in a manner independent of application software, hardware, and operating systems
Women's tunic sewing pattern available for download. Available in various sizes and is produced by burda style magazine.
A super easy make for the hottest summer days. Adjust the drawstring halter for a higher or lower neckline. You can tuck it into a skirt or throw it over a bikini for effortless summer style. Even better, it has invisible pockets.
Note: This is the same pattern PDF as the Halter Dress with Pockets.
This pattern is from the Festival of Colors collection.
Lightweight, softly draping jersey fabrics.
A, Silk jersey,
width: 135 cm (53 ins)
length: 1.20 m (1 3/8 yds)
This pattern doesn't include seam allowance
Produced by burda style magazine
Meg's Magazine Mash Up 2014
Take a look at Meg's 2014 Mash Ups, and get the special pattern bundle that includes them all
Web Seminar
Register today and get 20% off with a coupon code
Watch the promo video, and get the coupon code...
Online Course
Join Meg Healy in this 6 Week Course, we have just re-opened enrollment for a limited time!
Check out the top four finalists, and vote on your favorite dress
Editors' Picks
Check out these new 2015 patterns and cozy up to these wintery designs
You must allow our "request for permission" request to login to Burdastyle with Facebook.


text: The Black Flag reunion has suffered another blow - bassist Dave Klein has quit. Founder Greg Ginn and Ron Reyes regrouped the punk act last year (12), but things went sour on a tour of Australia and frontman Reyes was fired. Pro-skateboarder Mike Vallely, the band's former manager, announced he would be taking over vocals for dates in 2014 last week (ends31Jan14), but now it appears the band needs a new bass player. Klein took to his Facebook.com page to make his departure official shortly after Vallely's announcement, and wrote, "I guess I should OFFICIALLY say that I'm no longer playing with BF." Reyes then responded to his former bandmate's post, stating, "God Help their poor new bass player." Meanwhile, Vallely has written an online piece for sports news site ESPN, insisting Reyes was not fired from Black Flag - he quit. The X-Games star writes, "Reyes quit the band in November in Australia. He had informed Ginn and I several times that the Australian shows would be his last as vocalist for Black Flag. The day of the last show in Perth, he reiterated this to us in no uncertain terms. He texted me several times while we were in Australia, threatening to not play the shows at all and to just fly home. "He had been so temperamental the entire time we had been on the road that we were ready for anything at that point. Him flying home wasn't just a threat but a real possibility. Earlier in the summer in Hanover, Germany, he had actually quit the band on stage in a fit of rage. He threw his microphone down and stormed off the stage, screaming, 'That's it. I'm done,' only to return moments later when he realized the band would just keep going without him." Reyes has since responded to the claims, stating: "More lies. Consider the source people."


text:
Sign in
Sign Up
lowest rate guarantee
488 Kent Street
Corner Grand Pde And Princess Street, Brighton Le Sands
38 College Street
180 George Street
271 Elizabeth St
Great reasons to book with Agoda
Over 550,000 hotels worldwide – more added every day
Trusted by over 17,500,000 satisfied customers
Best Price Guarantee
9 million+ hotel reviews by Agoda customers
With availability in over 57,000 cities worldwide
agoda special offers
including last minute offers(even same day!)free nightsfree upgrades!
Customer Support
The staff, the location, the...
0.05 Km.
Location, comfortable, efficient...
0.08 Km.
Comfortable & spacious room in The...
0.09 Km.
0.11 Km.
Location. Room standard. General...
0.12 Km.
Location, rooftop balcony, Friday...
0.15 Km.
location, the breakfast in the...
0.18 Km.
0.2 Km.
Location is perfect for all the...
0.21 Km.
The view from room, location,Blu...
0.22 Km.
location, floor space (roomy),...
0.24 Km.
The view, staff performance,...
0.28 Km.
The staff from the front desk to...
Friendly staff, valet , location...
0.3 Km.
Friendly staff, great location and...
close to circular quay; well...
0.34 Km.
1- club InterContinental Lounge,...
0.36 Km.
Centrally located; warm, friendly...
0.37 Km.
Location was great, nice size...
0.4 Km.
Great location, 5 min water to...
0.43 Km.
4.5 / 5
over 80,000 reviews
of users recommend us
Go To Top
All material herein © 2005 – 2014 Agoda Company Pte. Ltd., All Rights Reserved.
AGODA ® is a registered trademark of AGIP LLC, used under license by Agoda Company Pte. Ltd.
Agoda is part of


text:
Deut. 10:12 "what does the LORD your God require of you, but to fear the LORD your God, to walk in all his ways, to love him, to serve the LORD your G... Read more
B.) SATAN'S 1ST REBELLION GEN.1:2 C.)THE EARTH RESTORED BLESSED GEN.1:2-25 2 PT.3:7 D.)SATAN ENTERS & THE CONSEQUENCE GEN.3... Read more
Notes Context of our text---verses 1-5 Remember that Mordecai was a Jew. When he heard that... Read more
The KJV New Testament Greek Lexicon Longsuffering Strong's Number: 3115 Original Word Word Origin makroqumiva from the same as (3116) Trans... Read more
The KJV New Testament Greek Lexicon Forbearance Strong's Number: 463 Original Word Word Origin ajnochv from (430) Transliterated Word TDNT ... Read more
DECEMBER 9 Greg's phone devotional BE WILLING to go out on a limb with Me. If that is where I am leading you, it is the safest place to be. Your desi... Read more
Verse 1. Brings the thought or to my mind the lords prayer.. Library by let we your will be done on earth as it is in heaven. Verse 3. States tha... Read more
I like these two verses I john 1; 7,9.to me its saying if we not only confess but walk in the light , we will be cleansed from all unrightousness, the... Read more
These verses are talking about Yeshua! King of kings and Lord of lords!!
eph. 1:15-23; 3:14-21; phil. 1;9-11; col. 1(-12


text:
Date: 2 years ago
Runtime: 1:12
Views: 4,376
me fucking
i just fuck one of my friends, he is so hot LOL
Categories: Amateur, Interracial, Hardcore
Top Comments
All Comments
Hot mate you can fuck me anytime
fuck my ass, too please
fuck me
too hot with sound, i love
lucky guy getting fucked by you,ps tasty arse you got there too
http://www.xtube.com after you shoot your load, take a piss inside me!
wish we can meet & u can fuck my asian arse ;-)
would be heaven to be fucked by you like this hot bottom
lucky friend!
that was so hot!


text:
David J. Lane (ambassador)
|David J. Lane
|10th United States Ambassador to the United Nations Agencies for Food and Agriculture
|Assumed office
July 19, 2012
|Barack Obama
|Preceded by
|Ertharin Cousin
|Personal details
|Political party
Philanthropic executive
David J. Lane is the United States Ambassador to the United Nations Agencies for Food and Agriculture, serving in Rome, Italy, and chief of the United States Mission to the UN Agencies in Rome. Before that he held several positions in the U.S. federal government and with philanthropic organizations, including being President and Chief Executive Officer of the ONE Campaign.
Early life and education[edit]
Lane was born c. 1960.[citation needed] Lane grew up in Indialantic, Florida, and graduated from nearby Melbourne High School in 1978.[1] He received a Bachelor of Arts degree from the University of Virginia,[when?] and then a Master of Public Affairs from Princeton University's Woodrow Wilson School of Public and International Affairs.[when?][2]
Early career[edit]
Lane worked as a legislative assistant focusing in the area of foreign policy in the United States Congress for Senator Gary Hart.[2][3]
Clinton administration[edit]
From 1993 to 2000, Lane worked for the U.S. federal government during the Clinton administration.[3] These included being Chief of Staff to the United States Secretary of Commerce, William M. Daley, and Executive Director of the National Economic Council.[2][4]
Philanthropic work[edit]
In 2001, Lane was hired by the Bill & Melinda Gates Foundation, as part of expanding its presence in Washington, D.C., and maturing as a philanthropic organization.[5] Lane served as Director of Public Policy and External Affairs, Director of Foundation Advocacy, and Director of the East Coast Office for the foundation, where he had responsibility for that organization's advocacy and public policy work on a range of matters that included global development and global health.[2][3] He was a Gates Foundation representative to Bono's DATA organization that focused on problems in Africa.[1]
In 2007, DATA merged into the ONE Campaign, and Lane was named as president and chief executive of the latter.[6] He emphasized the organization's purpose in fighting global extreme poverty and disease and urged leading countries to continue their commitment to bettering Africa, even in face of the late-2000s financial crisis.[7]
Lane also served as vice-chair of the board of Transparency International USA, and is a member of the Council on Foreign Relations.[2]
Obama administration[edit]
In early 2011, Lane joined the Obama administration during a period of staff change, serving as Assistant to the President of the United States and Counselor to the Chief of Staff in the White House, once again working for William M. Daley.[2][4]
U.S. Ambassador[edit]
Lane was nominated by President Barack Obama on April 16, 2012, to serve as United States Ambassador to the United Nations Agencies for Food and Agriculture.[2] The United States Senate confirmed Ambassador Lane on May 24, 2012.[2] He was officially sworn into the position on July 19, 2012.[8]
This article incorporates public domain material from the United States Government document "U.S. Ambassador – David J. Lane".
- ^ a b Biscardi, Sharon (January 19, 2003). "Celebrities meet in Brevard town". Florida Today. p. 1.
- ^ a b c d e f g h "U.S. Ambassador to the United Nations Agencies in Rome, Italy". United States Mission to the UN Agencies in Rome. Retrieved August 4, 2012.
- ^ a b c "David Lane". ONE Campaign. Retrieved August 5, 2012.
- ^ a b Kamen, Al (February 26, 2011). "The Obama staff shuffle kicks into high gear". The Washington Post.
- ^ Houtz, Jolayne (October 28, 2001). "Gates Foundation wields newfound clout". The Seattle Times.
- ^ "Bono's U.S.-based anti-poverty groups to merge". Reuters. October 29, 2007.
- ^ Rujumba, Karamagi (September 24, 2009). "Panel presses summit leaders to recommit to Africa". Pittsburgh Post-Gazette.
- ^ "Arrival of Ambassador David J. Lane" (Press release). United States Mission to the UN Agencies in Rome. July 23, 2012.
- Living people
- People from Brevard County, Florida
- Florida Democrats
- University of Virginia alumni
- Woodrow Wilson School of Public and International Affairs alumni
- American philanthropists
- Representatives of the United States to the United Nations Agencies for Food and Agriculture
- Obama Administration personnel
- United States Department of Commerce officials


text:
Contract.OldValue<T> Method
.NET Framework 4.5
Represents values as they were at the start of a method or property.
Namespace: System.Diagnostics.Contracts
Assemblies: mscorlib (in mscorlib.dll)
System.Diagnostics.Contracts (in System.Diagnostics.Contracts.dll)
The following example shows the use of the OldValue<T> method to ensure that a count has been updated. This code example is part of a larger example provided for the ContractClassAttribute class.
.NET FrameworkSupported in: 4.6, 4.5, 4
.NET Framework Client ProfileSupported in: 4
Portable Class LibrarySupported in: Portable Class Library
.NET for Windows Store appsSupported in: Windows 8
Supported in: Windows Phone 8.1
Supported in: Windows Phone Silverlight 8.1
Supported in: Windows Phone Silverlight 8
Windows Phone 8.1, Windows Phone 8, Windows 8.1, Windows Server 2012 R2, Windows 8, Windows Server 2012, Windows 7, Windows Vista SP2, Windows Server 2008 (Server Core Role not supported), Windows Server 2008 R2 (Server Core Role supported with SP1 or later; Itanium not supported)
The .NET Framework does not support all versions of every platform. For a list of the supported versions, see .NET Framework System Requirements.


text:
Tag Archives: Actual Cafe
Bites: What's new, what's hot, what's happening, II
Bites is Berkeleyside Nosh's round-up of restaurant, bar and food-related news in the East Bay. To stay up-to-speed with all that's going on locally, read our daily Nosh Wire, and check out previous editions of Bites. We always love receiving food-related tips at firstname.lastname@example.com.
Freshly served…
VICTORY BURGER Last week, we gave notice that Victory Burger, a new venture in north Oakland from the folks behind Actual Café, was about to open. Well, the first official day of business was Friday. In addition to the burgers, hand-cut fries and shakes on the menu, there's also roasted chicken banh mi and both pork and gluten-free veggie arepas (a cornmeal South American street food). There are also several interesting "add-ons" for both the burgers and fries that sound pretty delicious: Avocado Mayo, Chicken Skin Mayo (wait, what?), and Bacon Gravy. Victory Burger, 1099 Alcatraz Ave., Oakland.
INNA JAM INNA Jam, the artisanal preserve company started by former freelance commercial video editor Dafna Kory in Berkeley, moved into a new commercial kitchen in Emeryville at the beginning of the summer, and has been busy processing a big crop of berries and stone fruit since then. Kory also recently opened an INNA Jam store — really just a shelf in the corner of the kitchen. It's stacked with jars of every jam they make, many of which are not available in retail stores or online. Regular hours are Tuesdays and Wednesdys from 2–5 p.m. (and by appointment). INNA Jam, 1307 61st St., Emeryville, 510-214-6620. … Continue reading »
Tagged Actual Cafe, Bagels, Beauty's Bagel Shop, Berkeley dining, Bites: What's new in East Bay food, Chez Panisse, Coffee, Diving Dog Brewhouse, East Bay drinking, Fiveten Burger, Handlebar, Hog's Apothecary, Homestead, Hopscotch, INNA jam, Lost and Found Beer Garden, Oakland dining, Ramen Shop, Ronca's Kitchen, Rosamunde Sausage Grill, Scream Sorbet, Sea Salt, Sliver Pizzeria, Sportivo, St George Spirits, Sweet Bar Bakery, Temescal, The Forge, The Meatball Shop, Timeless Coffee Roasters and Bakery, Victory Burger
Actual Café spin-off Victory Burger to open soon
Update, 11.29.12: Victory Burger opened on Friday Nov. 23. (Read Berkeleyfarm's snapshot review in the Comments.)
Victory Burger, a new venture from the good folks behind Actual Café on San Pablo Avenue, will open imminently, says Sal Bednarz, owner of both operations. How soon? Well, he wouldn't be specific, but put it this way: burgers are cooking up on the grills already. "We will be open by the time you publish your story," he told Berkeleyside Tuesday. (Given how quickly we go to press, we would advise readers to follow Victory Burger on Facebook for updates on its actual opening, however.)
The burger place, which is at 1099 Alcatraz Ave., next door to the Actual Café, will serve locally and sustainably farmed meat burgers, with artisan buns and organic produce, along with other sandwiches, crispy fries, and shakes. … Continue reading »
Tagged Actual Cafe, Coffee, Victory Burger
Actual Café launches Bicycle Bingo fundraising parties
Actual Café has had a novel idea for groundhog day — which, as it happens is today — and for every week after today. The whole point of groundhog day, after all, is that it repeats itself.
The San Pablo Avenue café is launching "Bicycle Bingo", a weekly fundraising bingo game and party that will benefit several nonprofits active in Berkeley and Oakland.
The event will feature the area's only bicycle-driven bingo ball machine, and will be MC'ed by Berkeley's Steffy Sue on the Uke.
"We like games and parties, and we like to support organizations who do good work in our own backyard, so this event is a no-brainer," says Sal Bednarz, owner of Actual Café, which is known for its love of all things bike-related. "We want to help these organizations find a wider audience, and make it easy and fun for folks to give them some support (and maybe win a prize!)." … Continue reading »


text:
An exclusive look at how JimFielding is taking this upstart, multi-channel YouTube network and
its most popular content creators into the world of brand building, licensing and beyond.
The late famed pianist Liberace is set to play for audiences once again, thanks to a new partnership between the Liberace Foundation and Hologram USA.
Rapper Wiz Khalifa's record label and management company Taylor Gang Entertainment has partnered with Grenco Science for a series of vaporizer products.
Entertainer Rihanna has been named as a global ambassador and women's creative director for Puma.
Footwear retailer DSW has partnered with the Broadway's musical "Kinky Boots" to launch an exclusive capsule collection at a store in New York City.
Marley Coffee, the Bob Marley branded coffee brand created under license from 56 Hope Road, has partnered to distribute its coffees in Colombia and Mexico.
Entertainment One has signed on to create and distribute original content for filmed media featuring the YouTube singing group Cimorelli.
PhotoBox Group, a digital service for personalized products in Europe, has teamed with Global Merchandising Services to bring boy band One Direction to all of its platforms.
Yoko Ono will release three rare archival sketches from the late John Lennon's Bag One Arts program at exclusive exhibitions around the U.S. beginning this month.
Norwegian Cruise Line Holdings has partnered with Margaritaville Holdings to bring a Jimmy Buffet-inspired experience to the high seas.
Baby brand aden + anais and global AIDS charity (RED) have launched a designer collaboration with Jessica Alba, Gwen Stefani and Rachel Zoe.
ITV Studios Global Entertainment is ready for a banner year with a number of new and returning shows leading its licensing pushes.
Musical instrument manufacturer Peavey Electronics has launched a line of officially licensed Major League Baseball instruments and accessories.
The legendary rock band KISS has tapped global branding, merchandising and rights management company Epic Rights to build its brand.
DC Thomson Consumer Products has teamed with John Hornby Skewes for a line of musical instruments that features characters from The Beano.
Two of Robin Thicke's new singles will serve as the inspiration for rose bouquets from 1-800-Flowers.com.
The Country Music Association is working to build awarenss of the plethora of licensing opportunities the genre presents.
Pharrell Williams and avant-garde fashion house Comme des Garcons have launched a wood-based fragrance for girls and boys called GIRL, available exclusively at Sephora.
Rock band KISS will makes its first-ever appearance in this year's 88th Annual Macy's Thanksgiving Day Parade.
The Grateful Dead celebrates 50 years of music, art, culture and licensed products.
Rapper 50 Cent's SMS Audio unveiled a new line of limited edition Star Wars-branded headphones at the Consumer Electronics Show this week.
©2014 ADVANSTAR COMMUNICATIONS INC. All rights reserved.


text:
Monaco made a late transfer-deadline day move to cover for Radamel Falcao`s long-term injury absence by signing striker Dimitar Berbatov on loan from English Premier League strugglers Fulham on Friday.
Dimitar Berbatov has been threatened for sending flirty texts to a gangster's lover.
Dimitar Berbatov has vowed to score more goals this season with added responsibility on his shoulders after the departure of Cristiano Ronaldo and Carlos Tevez from Old Trafford.
Day in Pics: 22nd December
Showbiz World - December 22, 2014
Sunny Leone with Mastizaade


text:
Prices and position is good but the quality of rooms is quiet low, beds are deff not confortable and air conditioning is noisy. Bathroom is ok. Breakfats is good .position good near obelisque metro bus. Staff is helpful
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Hotels.com, Priceline, TripOnline SA, Despegar.com, Travelocity, Odigeo and Tingo so you can book your San Remo City Hotel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text:
Update the BIOS from floppy boot disk?
I have an Asus P4P800 E deluxe motherboard and it has issues with installing or even getting linux to run , I tried knoppix and ubuntu's live cd's and they dont even work with my motherboard and was wondering if anyone knew how to fix it, I think the only fix I have found was updating the bios but I am not sure which version of the bios I would require.
Anyone got any ideas or input ?
P.S I think I found a live update feature on the Asus disc that came with the motherboard however I am on wireless which tends to cut out a lot.
I basically wanted to know if there were any work arounds other then the bios update.
Update the BIOS from floppy boot disk?
My computer doesnt have a floppy disk drive, I forgot to mention that lol
I have an internal Pioneer DVR 109 however so If I could get the bios file would I just make a bootable cd and burn the bios file to the disc along with the other things that are on the disc or how would I do it ?
Yes, A bootable CD would work. I have to do that with my Wintendo machine. You can grab a premade one from http://www.bootdisk.com All you need to do is alter it to include your bios flashing utility and the bios image.
I've read up a bit more on the ASUS board. You'll need to grab the drivers from the ASUS site for the onboard gigabit nic and the onboard sound card.
What wireless card do you have, you might have trouble with that too.
To save you farting around burning a disc, why not use a USB floppy?
Knoppix, Kubuntu, ubuntu and linspire [all the live cd's i've tried] work on my P4P800 VM's
I dont have wireless onboard , its just the onboard audio which ive disabled and the gigabit nic.
I dont got a usb floppy - This is my home machine and I just wanted to get linux working but it wasnt a high priority thing but I just wanted to know how I could get it to work and was just curious on the replies I would get
Thanks for the help though ! Much appreciated as usual !
@Geoff[plus anyone else that can help o'course ] - I have a home machine with an ASUS A8V wireless edition at home - I'd love to get linux on it but the wireless is holding me back, as I like to have it connected that way - any suggestions??
Its a rt2500 chipset. Thus uses the rt2x00 driver.
Either you've been Googling again Geoff or you need to get out more!Originally Posted by Geoff
I have a rt2x00 based card here so I know all about it.Originally Posted by Ric_
Just as an update I used the update utility that came on the motherboard cd.
It updated the bios using the bios update file I downloaded.
That is scarey though because if someone can make an exe to update the bios then I am sure there must be viruses out there that write wrong info to the cmos and that would be me screwed if that ever happened to me !!
It got ubuntu and knoppix working on my motherboard , YAY !!!!
Just a quick one Geoff, what are some good distros of linux you can recomend, I saw you use gentoo and there was a mention of debian but are there any other ones you can recomend ?
I forgot to mention, dont spose you have any tutorial / walk through sites that show how to dual boot linux with windows xp ?
Just I could really use both on my machine because that would be nifty >
Yes there are Bios viruses around. They used to be a lot more common than they are now though as they usually travel via infected floppy disks in the boot sector. Most Bios's have virus protection too now.
As for distro's just try some out. Fedora, Mandriva and Suse are good starting points. Debian is good for servers (if you want debian for the desktop, use Ubuntu). As I've said I use Gentoo but its not really newbie friendly. You can try it if you like though.
As for dual booting, most distro's will detect windows and setup the dual boot first. The only time this wont work is if you install Windows after you install Linux. I really don't recommend that. As for the specifics I'd need to know which Boot manager you plan to use. Grub or Lilo?
There are currently 1 users browsing this thread. (0 members and 1 guests)


text:
- Home
- About Israel
- News & Blog
- Issues
- Peacekeeping
- Security
- Terrorism
- World Opinion
- Take Action Now
Rabbi's Commentary
Answering His Call, Faithfully and Joyfully
2014 has certainly been a year of struggles. But those challenges have been answered by God, and by His faithful followers. The Fellowship and our generous friends have been able to offer assistance to those who need it most, from the Holy Land to the former Soviet Union, and we look hopefully to the coming year as one of peace, prosperity, and repairing the world.
Read Rabbi Eckstein's Message »
Learn About Israel
Find out the story of
this amazing land.
The Land of Israel
The History of Israel
War, Peace, and Politics
Read more »
News From Israel


text:
18 Volt Cordless Cut-Out Tool with Tool-Free Bit Change and 26,000 RPM
The DeWalt 18 volt cordless cut-out tool is extremely durable and efficient. This amazing tool features a 26,000 RPM motor which provides more cutting power. Making these even more versatile is the tool-free bit change for fast and easy bit changing without a wrench.
- Tool-free bit change for fast and easy bit changing without a wrench
- 26,000 rpm motor provides more cutting power
- Dust sealed switch provides durability and long switch life
- Includes:
- 1 general purpose bit
- 1 drywall cutting bit
- 1/4" & 1/8" collets
- Tool only (batteries and charger sold separately)
- Voltage: 18V
- No Load Speed: 26,000 rpm
- Collet Diameter: 1/4", 1/8"
- Adjustable Guide: Yes
- Tool Weight: 2.1 lbs
- Shipping Weight: 2.5 lbs
DEWALT is firmly committed to being the best in the business, and this commitment to being number one extends to everything they do, from product design and engineering to manufacturing and service.
Additional DeWalt Links
Our SKU: DeWalt DC550B
This product is listed under the following manufacturer number(s):
- DeWalt DC550B
*Denotes a finish or option that has been discontinued
Product Videos
How To Make a Sawhorse out of a PalletMuir shows you how to make a sawhorse using a recycled pallet.
Installation Resource Center
Whether you are installing the product yourself or hiring a professional, our installation Resource Center has everything you need to get your project done. Visit the Installation Resource Center to get started.


text:
August 21, 2014
Portland's Ken Joyce is living the dream
The baseball life still burns brightly for Maine native Ken Joyce after a two-decade career in professional baseball.
August 20, 2014
Sea Dogs rally to beat Harrisburg, 5-3
First-place Portland remains two games in front of Binghamton in the EL East.
August 19, 2014
Sea Dogs head to playoffs
Portland clinches a postseason berth for the first time in six years, then opens a two-game division lead with a come-from-behind victory.
August 18, 2014
Host families, Sea Dogs players really connect
Nearly every athlete on the team's roster is staying at a local home this summer, a rare housing practice at the Double-A level where the friendships often go deep.
August 17, 2014
Sea Dogs on threshold of playoffs with 7-1 win over Richmond
Portland continues to lead the East Division with a 1 1/2-game lead over Binghamton.
August 16, 2014
Just enough of the Force with Sea Dogs
On 'Star Wars' night, the Sea Dogs edge Richmond 1-0 in 10 innings.
August 15, 2014
Sea Dogs show offense in support of pitching to beat Flying Squirrels
Eduardo Rodriguez strikes out seven in six innings of a 5-1 victory.
August 14, 2014
Sea Dogs lose doubleheader to Akron, 4-2 and 1-0
Portland has now lost six of its last seven games.
August 14, 2014
On Baseball: Sea Dogs have new players, but same old goal
Ten players who began the season with the Sea Dogs are now with Triple-A Pawtucket.
August 13, 2014
Sea Dogs' game at Hadlock rained out
Portland and Akron will play a doubleheader Thursday.
- ← Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- 8
- …
- 96
- Next Page →


text:
Archive for the 'networks' Category
abortion secrets in sociological science
Sociological Science has a new paper by Sara Cowan discusses when people share information using data on abortion:
Though abortion is a more common event in the United States than miscarriage, this article shows that more Americans hear of women who have had miscarriages than they hear of women who have had abortions. This is a result of both the patterns of secret telling and keeping: more Americans tell miscarriage secrets to more people than abortion secrets, and more Americans keep abortion secrets from more people than miscarriage secrets.In the introduction, I described two scenarios: one in which people tend to hear secrets they previously approved, and this pattern would contribute to a stasis in public opinion and a second scenario in which people hear secrets they previously condemned and this scenario would inspire social influence and facilitate social change. The data analyzed here illustrate the first scenario. They show a strong trend whereby individuals who hold restrictive views toward abortion are less likely than their liberal peers to report knowing someone who has had one. People tend to hear those secrets about which they already approve and are less likely to hear secrets about which they disapprove. Secret keeping and selective disclosure intensify this experience of homophily above and beyond any objective network segregation.
this is not a post about ello
This is not a post about Ello. Because Ello is so last Friday. But the rapid rise of and backlash against upstart social media network Ello (if you haven't been paying attention, see here, here, here) reminded me of something I was wondering a while back.
Lots of people are dissatisfied with Facebook — ad-heavy, curated in a way the user has little control over, privacy-poor. And it looks like Twitter, which really needs bring in more revenue, is taking steps to move in the same direction: algorithmic display of tweets, with the ultimate goal of making users more valuable to advertisers.
The question is, what's the alternative? There have been a lot of social network flavors of the month, built on a variety of business models. Some of them, like Google Plus, are owned by already-large companies that would be subject to similar business pressures as Facebook and Twitter. Others, like Diaspora (remember Diaspora?), were startups with an anti-Facebook mission (privacy, decentralization), but collapsed under the weight of their own hype.
I can't imagine that a public utility model would work for a social network — I just don't see "government-owned" and "fast-moving technological change" going together successfully. But I keep wondering why a Wikipedia model couldn't work. Make it a 501(c)3. Attract some foundation funding — it's a pro-democracy project. Solicit gifts from pro-privacy people in the tech industry — there are lots of those. Then once it's off the ground, ask users for donations.
Sure, there is the huge, huge hurdle of getting enough of a network base to attract new users. But it seems like the costs should not be insane. If it only takes 200 employees to run Wikipedia, as large as it is, how many would it take to get a big social network off the ground? Facebook employs 7000, but a lot of them have to be in the business of figuring out how to sell Facebook.
Maybe there have been (failed) efforts like this and I just haven't noticed. Or maybe the getting-the-user-base issue is really insurmountable. But it seems like if a real Facebook alternative is to emerge, it can't just be from a corporate competitor (e.g. Google), and the startup/VC model (e.g. Ello) is going to be susceptible to all the same problems as it grows. Why not a different model?
on facebook and research methods
Twitter is, well, a-twitter with people worked up about the Facebook study. If you haven't been paying attention, FB tested whether they could affect people's status updates by showing 700,000 folks either "happier" or "sadder" updates for a week in January 2012. This did indeed cause users to post more happy or sad updates themselves. In addition, if FB showed fewer emotional posts (in either direction), people reduced their posting frequency. (PNAS article here, Atlantic summary here.)
What most people seem to be upset about (beyond a subset who are arguing about the adequacy of FB's methods for identifying happy and sad posts) is the idea that FB could experiment on them without their knowledge. One person wondered whether FB's IRB (apparently it was IRB approved — is that an internal process?) considered its effects on depressed people, for example.
While I agree that the whole idea is creepy, I had two reactions to this that seemed to differ from most.
1) Facebook is advertising! Use it, don't use it, but the entire purpose of advertising is to manipulate your emotional state. People seem to have expectations that FB should show content "neutrally," but I think it is entirely in keeping with the overall product: FB experiments with what it shows you in order to understand how you will react. That is how they stay in business. (Well, that and crazy Silicon Valley valuation dynamics.)
2) This is the least of it. I read a great post the other day at Microsoft Research's Social Media Collective Blog (here) about all the weird and misleading things FB does (and social media algorithms do more generally) to identify what kinds of content to show you and market you to advertisers. To pick one example: if you "like" one thing from a source, you are considered to "like" all future content from that source, and your friends will be shown ads that list you as "liking" it. One result is dead people "liking" current news stories.
My husband, who spent 12 years working in advertising, pointed out that this research doesn't even help FB directly, as you could imagine people responding better to ads when they're happy or when they're sad. And that the thing FB really needs to do to attract advertisers is avoid pissing off its user base. So, whoops.
Anyway, this raises interesting questions for people interested in using big data to answer sociological questions, particularly using some kind of experimental intervention. Does signing a user agreement when you create an account really constitute informed consent? And do companies that create platforms that are broadly adopted (and which become almost obligatory to use) have ethical obligations in the conduct of research that go beyond what we would expect from, say, market research firms? We're entering a brave new world here.
university of chicago visit – everything you wanted to know about tweets and votes, but were afraid to ask
I will be a guest of the computational social science workshop at the University of Chicago this coming Friday. I will present a very detailed talk on the more tweets/more votes phenomena called "Everything You Wanted to Know About the Tweets-Votes Correlation, but Were Afraid to Ask." If you want to chat or hang out, please email me.
Refreshments will be served.
50+ chapters of grad skool advice goodness: From Black Power/Grad Skool Rulz
comments on andrew gelman's dec 21 post
Last Saturday, Andrew Gelman responded to a post about a discussion in my social network analysis course. In that post, my student asked about different strengths of a network effect reported in a paper. Gelman (and Cosima Shalizi) both noted that the paper does not show a statistically significant difference. I quote the concluding paragraphs of Andrew's commentary:
I'm doing this all not to rag on Rojas, who, after all, did nothing more than repeat an interesting conversation he had with a curious student. This is just a good opportunity to bring up an issue that occurs a lot in social science: lots of theorizing to explain natural fluctuations that occur in a random sample. (For some infamous examples, see here and here.) The point here is not that some anonymous student made a mistake but rather that this is a mistake that gets made by researchers, journalists, and the general public all the time.
I have no problem with speculation and theory. Just remember that if, as is here, the data are equivocal, that it would be just as valuable to give explanations that go in the opposite direction. The data here are completely consistent with the alternative hypothesis that people follow their spouses more than their friends when it comes to obesity.
Fair enough. Let me add a pedagogical perspective. When I teach network science to undergrads, I generally have a few goals. First, I want to show them how to convert social tie data into a matrix that can be analyzed. Second, I want students to learn how network concepts might operationalize social science concepts (e.g., how group cohesion might be described as high density). Third, I want to spark their imagination a little and see how network analysis can be used to describe or analyze a wide range of phenomena and thus encourage students to generate explanations. Given that students have very, very modest math skills and real problems generating hypotheses, getting down into the weeds with the papers is often last.
So when I teach the week on networks and health, my discussion questions are like this: "Why do you think health might be transmitted from one person to another? How would that work?" I also try to get into basic research design: "How do you measure health? Do you know what BMI is?" So the C&F paper has many up sides. The downside is that the paper has an interesting hypotheses and you can easily get distracted from the methodological controversy the paper has generated, or even some very sensible observations on confidence intervals. The bottom line is that when you have to teach everything (theory, methods, research design and topic), you don't quite get everything. But still, if a student, who self-admitedly knows little math or stats, can get to a point about asking about mechanisms, then that's a teaching victory.
Post-Christmas blow out: From Black Power/Grad Skool Rulz


text:
Amber Blackman
Dec 4, 2014
Jonathan E. Benedict
Oct 30, 2014
Darrell W. Cook
Oct 2, 2014
Michael Polchies
Sep 25, 2014
Home » News » Crime
Gang rivalry at center or three recent Manchester shooting incidents
The scene of a shooting in Manchester, in the area of Spruce and Lincoln streets. (Pat Grossmith/Union Leader)
Velez Jr. is reportedly a member of the "180" gang, while Weekly is a member of OTL — the Orange to Laurel streets gang. Both Velez Sr. and Velez Jr. were arrested in connection with the melee that drew a crowd of about 30 people and required 18 officers and 30 minutes to quell.
Police have not said what is at the heart of the dispute but in the ensuing months, violence has escalated into shootings between the rival gangs.
That includes two special, two-man patrol cars to deal with issues in the affected neighborhoods, and added patrols Thursday through Friday in the area of downtown nightclubs.
"They're working on different staffing procedures," he said, noting that 14 more police officers will be sworn in on July 7. "Certainly, it's important that we do everything we can to curtail it."
"We need stricter laws on guns. There's too much "Live Free or Die," said the woman while holding her baby son.
"I grew up in Lowell, Mass.," he said. "So this is a paradise compared to where I grew up."
- In Gorham, landlord saw a change in kidnap suspect - 0
- Family of abduction survivor Elizabeth Smart offers hope in wake of Conway teen's ordeal - 1
- Feds step up protection against sexual violence - 0
- 2 more arrested over alleged drug dealer robbery in Exeter - 0
- State seeks to address handling of campus assaults - 0
- Update: Londonderry search of shooting victim's home has concluded - 0
- N.Y. man sentenced in sex assault of NH child in 1988 - 0
- Hearing ordered in 1971 murder - 0
- Police investigating bank robbery in Nashua - 0
Tensions boil over after NYC police killingsREADER COMMENTS: 0
- Dave D'Onfrio's Patriots Notebook: Finding a way to win - 0
- Sam Asano's Let's Invent: NoNose gets readers talking like nobody's business - 0
- Another View -- Bill O'Brien: Ask your state rep. to vote for transparency in the House - 0
- Old friends and a 'homeless angel' make for good stories anytime - 0
- Clooney gets it: Sony attack was not a 'crime' - 0
- New coats warm city kids, firefighters' hearts - 0
- NHIAA Roundup: Martin, Pinkerton top Salem in tournament - 0
- Inmate reported missing from Concord transitional unit - 0
- College Roundup: SNHU women win - 0
These all-natural candles can double as massage oilREADER COMMENTS: 0
The Sony hack: Kim's judgment of Obama
Tensions boil over after NYC police killings
- Whom do you think bears the brunt of the blame for the mayhem this weekend in Keene?
- KSC students
- 37%
- KSC administration
- 2%
- Police
- 6%
- Visitors from out of town
- 18%
- A combination of any/all of the above
- 37%
- Total Votes: 2483


text:
Welcome to jrdwyer's Member Page
See my Clippings See my Journal See my trade list Send me an email
I work as an independent forestry consultant. I am originally from Ames, Iowa and have a B.S. Degree in Forestry from Iowa State University (1989). I love trees, forests, and things made out of wood. I have a great wife and a wonderful young son.
I live in: United States
My zone is: southern IN
My favorite forum 1 is Trees.
My favorite forum 2 is Flooring.
First registered on March 29, 2003 .


text:
- Home
- News
- Sports
- Classifieds
- Obituaries
- Lifestyles
- Special Sections
- E-Edition
NEWPORT CITY ŌĆō The North Country Union High School Board will be looking for a new director for the North Country Career Center.
Richard Hoffman confirmed Monday that he handed in his resignation at last TuesdayŌĆÖs Resources Committee meeting. Human Resources approved the request with regret. The full board will act on the resignation at tonightŌĆÖs monthly meeting.
Hoffman, who wants to pursue other opportunities, said he has nothing lined up. Hoffman has been an educator for 34 years and has an impressive background, which includes being the technical adviser for Armenia for the State of Kansas. Hoffman said his vision of technical education has somewhat changed over the past 34 years.
ŌĆ£I believe we do a huge disservice to high school students if we say that technical training is enough,ŌĆØ said Hoffman, who stressed that doesnŌĆÖt necessarily mean four years of additional education. ŌĆ£I want to affect true changes along those lines.ŌĆØ
Hoffman stressed that the technical education provided by the North Country Career Center is second to none.
ŌĆ£They do a wonderful job here,ŌĆØ he said. ŌĆ£It relates to the jobs in the area. It has good skill sets that engage students who might otherwise drop out of school and allow those students to graduate and become successful.ŌĆØ
Hoffman is licensed as a superintendent in Kansas and has filled the paperwork to be one in Vermont. He would also consider working as a principal or helping a company educate its employees.
ŌĆ£IŌĆÖm looking for the next opportunity,ŌĆØ he said. ŌĆ£Most people in my position who have been around for 34 years or more have retired. I havenŌĆÖt quite gotten there yet.ŌĆØ
Hoffman would like to remain in the Northeast Kingdom and would not rule anything out for the right position. He said he resigned now, instead of waiting until he found something, to be fair to the school board who needs time to find his replacement.
HoffmanŌĆÖs resignation didnŌĆÖt come as a surprise to Superintendent Robert Kern. Kern said the two have been talking for a few months. Kern also said that Hoffman will be missed.
Board Chair Arne Amaliksen stressed the board didnŌĆÖt initiate HoffmanŌĆÖs resignation and, from his point of view, he had no complaints in regards to Hoffman. ŌĆ£He was qualified,ŌĆØ said Amaliksen, who said the next candidates may be a "better fit."
ŌĆ£Apparently heŌĆÖs not wanting to stay on because he submitted a resignation. You have to assume there is some desire on his part to separate. There are those who would have fought and battled if they thought there was a good fit.ŌĆØ
The human resources committee has setup a committee to search for HoffmanŌĆÖs replacement. Amaliksen will recommend the board chose Grant Spates to head up the committee. HoffmanŌĆÖs last day will be June 30. Amaliksen expects the board will hire HoffmanŌĆÖs replacement this summer. Even if that doesnŌĆÖt happen, the school board still has Assistant Director Eileen Illuzzi.
ŌĆ£WeŌĆÖre not real thin in that area as far as having somebody there to help in administration,ŌĆØ said Amaliksen.
In June, Hoffman will have been at North Country for three years. He replaced Bob Fitts.


text:
News Tagged: Brooklyn
©12ozProphet - Monday November 03, 2014
Traveling Nightclub Shade Holds Epic Halloween Party in Abandoned Factory...This past Friday Brooklyn's traveling club, Shade, organized a Halloween party of immaculate proportions and bacchanalian magnitude. The sold-out event took place in an abandoned factory in Greenpoint, Brooklyn, and bolstered a thousand plus eccentrically costumed attendees, including celebrity designer, Riccardo Tisci.
©12ozProphet - Monday November 03, 2014
Openings - What A Character Group Show at Low Brow ArtiqueExploring our character culture, See One curates a group show with some of the most recognizable artists this August at Low Brow Artique.
©12ozProphet - Friday August 01, 2014
Openings: TIMEBOMB: Three Decades of Style WritingHappening Friday, July 25th in Brooklyn
©12ozProphet - Friday July 25, 2014
12oz Exclusive: Queen Andrea - Bright Lights Big CityThe always colorful Queen Andrea has been getting busy lately, with her walls, typography murals and trucks popping off all around NYC.
©12ozProphet - Thursday July 24, 2014
In Motion: SEN2, YES1, OWNS, FIBS, LOGEK & EPIC & VIZIEOne solid weekend of painting in Brooklyn
©12ozProphet - Thursday July 24, 2014
Seen on the Streets: MASTRO, WEN, TONE, HACE & SAVSSun and spray action last week in Brooklyn
©12ozProphet - Wednesday July 16, 2014
Seen on the Streets: DMOTE, OWNS, GREVE, LOGEK, SEBS & BOGUSMore walls from Brooklyn as the summer gets into full swing
©12ozProphet - Wednesday July 09, 2014
Openings: CANvas Spray Can Art ShowHappening Wednesday, July 9th in Brooklyn
©12ozProphet - Wednesday July 09, 2014
Seen on the Streets: NECKFACE, EMONENECKFACE and EMONE rolling through Brooklyn
©12ozProphet - Tuesday July 08, 2014
Openings: VERSUSHappening Wednesday, July 2nd
©12ozProphet - Tuesday July 01, 2014
Seen on the Streets: VOR 138 x HOACS in Bushwick, BrooklynThe stars and stripes come out just in time for Independence Day
©12ozProphet - Tuesday July 01, 2014