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Christmas on the Comstock
December 6, 2014
Step back in time this holiday season and celebrate Christmas as they did in the 19th century. Historic Virginia City hosts its annual Christmas on the Comstock this December, offering a Victorian-style holiday celebration. There are festivities for all ages ranging from unique boutique holiday shopping, specials, a holiday parade on December 6 and more. Here's a full listing of holiday events in Virginia City.
The Candy Cane Express Trains
Christmas Movies at Piper's Opera House
10 AM - It's a Wonderful Life
10 AM: Artists and Artisans Art Faire on the Comstock
5 PM: Christmas on the Comstock Parade of Lights
Photos with Father Christmas at the Visitor Center/Or meet Jolly Santa Claus at the Roasting House December 6 only
7:30 PM: Christmas in the Sierra – Concert with David John & The Comstock Cowboys
More details to come!
Parade of Lights
The Parade of Lights sweeps down C Street at 5 p.m., lighting up the town and spreading Christmas cheer along the way. Parade entries must be lit. Think you have a bright idea? Download the entry form to join the parade.
Thanks to these great sponsors for making this event possible:
Promoted and managed by:


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Willow poles for sweet peas
Ideal for runner beans and sweet peas these natural looking willow poles look far better than bamboo canes also as there have a rougher bark it's easier for plants to cling to as they climb up the poles. Each pole consists of two willow canes beautifully wrapped around each other and tied together for added rigidity and great looks.
There are currently no 'goes well with' suggestions for this item.
Reviewed by 1 customer
- Easy To Use
- Lightweight
- Solid Construction
- Weather Resistant
Best Uses
- Gardening
Comments about Willow poles:
Beautiful in the garden, good supports for climbing plants. Bring in over winter or when not in use.
- Your Gardening Experience:
- Experienced
Do you want to ask a question about this?If so, click on the button and fill in the box below. We will post the question on the website, together with your alias (bunnykins, digger1, plantdotty etc etc) and where you are from (Sunningdale/Glasgow etc). We'll also post the answer to your question!
1 Question | 1 Answer
Displaying question 1
Q:Would these canes be able to support clematis such as Black Prince or Madame Julia Correvon?Asked on 5/26/2014 by Anila from Rcikmansworth
1 answer
These canes are reasonably strong, so they should be able to support smaller Clematis - particularly those that get cut back each year.Answered on 5/30/2014 by helen from crocus
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subset: commoncrawl


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Pregnancy Chat - December
Find a Conversation
|Sat, 12-01-2012 - 10:36pm
Sandy - March 23rd, 2013 - TEAM PINK!
Cassie/CJ (cassiejune) - March 29th, 2013 - TEAM PINK!
Ruby - April 13th, 2013 - TEAM PINK!
Erin/"E" - April 15th, 2013 - TEAM BLUE!
Ella - May 24th, 2013 - TEAM YELLOW!
Suzie - May 29th, 2013 - TEAM YELLOW!
Mandy - June 2nd, 2013 - TEAM BLUE!
Christine - July 8th, 2013 - TEAM YELLOW!
Cassie (squeaker02) - July 9th, 2013 - TEAM YELLOW!
Alison - July 28th, 2013 - TEAM YELLOW!
|Tue, 12-04-2012 - 1:02pm
Where is everybody this week? It's awful quiet around these parts ...
My in-laws lost the house they were hoping to buy here :( Back to square one for them. They may end up staying with us in January, for an unknown amount of time .... eek. We only have a two bedroom apartment, all on one floor. Our living room only has seats for two people. And we have a cat. Add my in-laws plus FOUR dogs???? And me pregnant? Oh boy .... this should be interesting.
Hope everyone is having a nice week so far. My back is killing me today. :( DH and I are going to do a little Christmas shopping after dinner this evening, for his kids.
|Tue, 12-04-2012 - 2:32pm
I'm reading but not in the mood for posting right now. Sorry your parents didn't get the house they were hoping for. I'm sure they'll find something else soon, and won't have to stay with you for too long in January!
AFM - I have a follow-up u/s tomorrow to see if the baby is growing and if the heartrate is increasing (or if it isn't). The waiting is driving me CRAZY. Any positive thoughts you can send my way would be appreciated. I'll post once I know more.
|Tue, 12-04-2012 - 5:59pm
|Tue, 12-04-2012 - 9:28pm
|Tue, 12-04-2012 - 9:35pm
|Wed, 12-05-2012 - 8:29am
|Wed, 12-05-2012 - 1:34pm
|Wed, 12-05-2012 - 3:25pm
Name/SO Name: Alison & C
How many weeks are you? 6 weeks 3 days - or 7 weeks if you go by LMP
Any exciting dates/appointments this month? Yes! First appointment / ultrasound this Friday. Sooooo nervous.
Do you feel like you will go early or late? No idea!!
How are you feeling physically? The crazy tiredness is back. Bb soreness varies. And soooo bloated. Nausea is sporadic so I don't really eat meals anymore, just snack whenever hungry. Salt is best friend. Normally even the slightest bit of anything salty is too much for me, and now I would kill for fries & bacon. (And I normally don't like bacon!!)
How are you feeling emotionally? I'm terrified. So scared on Friday it won't be good news. So scared something will happen.
What's on your to-do list to get ready for baby this month? If all goes well at our appointment we will probably start announcing to close friends & family. (Aside from the 3 friends I've told.)
Do you know the gender yet? If not, are you thinking pink or blue? I've always thought pink for my first.
Sorry for being AWOL. Sitting at the computer is tiring! LOL. But seriously.
Christine - Can I get a ticker??? ;) DD should be 7/28. Don't beat yourself up about the fast food. If you're not doing it every day and it's really what you can hold down, don't feel bad. When are you thinking of telling Selin again?
Em - Ahhh, she'll be here any day!!!! I hope you're managing to stay somewhat comfortable.
Cassie - Glad you're feeling well. I'm sure the fam will love the ultrasound cards.
Ruby - Hope the u/s goes ok.
Sandy - Glad you're feeling well.
Mandy - LOL, just noticed you are "Mandy & Randy". TOO adorable. Sorry to hear about the back pain. Ooh, the registry sounds fun!! I forgot I get to do that!
E - Good for you on eating so well! DH does cook a few things that are his specialty, and a few I've been craving so he's been happy to oblige. But for the mostpart I cook since I work from home and he has 2 jobs. But sometimes laziness sets in and you just HAVE to order that pizza. Anyway. That sucks about your in-laws losing the house! I hope for sanity's sake they find something soon!
And Alyssa - There are really no words. I'm so, so very sorry. We're all here for you.
|Wed, 12-05-2012 - 9:44pm


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AboutBlue Ridge is a young church—we started meeting in the back of a local cafe in 2001, and broke ground on an actual home of our own on Spring Hill Road in 2003. Our pews (which are actually comfortable chairs!) are occupied by people who could have easily slipped into the back of large, established churches but have chosen to be here, where every pair of hands matters. When the sanctuary needs painting or the grass needs mowing, Blue Ridge folks pitch in. When 400 hungry neighbors need a hot meal on a winter night, the youth group cooks the spaghetti. We understand that church is not about what you can get but what you can give.
What will you find at Blue Ridge? A fresh pot of coffee and homemade treats on Sunday morning. The gentle donkey that shows up on Palm Sunday. At Advent, children dressed as angels and sheep under paper stars. Laughter, for sure; it wells up everywhere around here, even in the middle of the sermon. You'll find chances to serve: feed hungry neighbors in our own county, pick up a hammer and help build a school in Haiti or fix a roof here in Virginia. You'll find the Gospel; the word that can open a new window in the heart and let hope in. You'll find opportunities to bring that hope to someone else.
You're invited to share in the journey as we seek to love God with all our hearts, souls, and minds, and to love our neighbors and our world as we love ourselves.


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The Madeleine Brand Show for October 14, 2010
Reid-Angle Debate Preview
Ethan Miller/Getty Images
Former President Bill Clinton joins Senate Majority Leader Harry Reid (D-NV) at a pre-early vote campaign rally in Las Vegas, Nevada. Reid will face Republican Sharron Angle in the general election in November.
Senator Harry Reid and his Republican opponent, Sharron Angle, will meet for their first and only face-to-face debate tonight. Early voting begins Saturday.
A poll released today by the Las Vegas Review - Journal shows Angle leading 47 percent to Reid's 45 percent. That's within the margin of error.
Joining Madeleine once again to talk about tonight's Nevada Senatorial debate is Jon Ralston, columnist for the Las Vegas Sun.


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On September 17, 1976 NASA unveiled the first space shuttle to the public. Check out facts from the entire space shuttle era.
Space shuttle era factsUPDATED 8:32 AM CDT Sep 17, 2013
Slideshow Central
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December 18, 2014
NEW YORK (AP) - Northeast coastal residents got some good news Wednesday. Weather experts say that a new storm that threatens to complicate Hurricane Sandy cleanup efforts on Wednesday now looks like it will be weaker than expected.
The storm on Tuesday was moving from Florida toward the Atlantic. As it moves up the coast it is expected to move farther from shore than forecasters had thought. Jeff Masters of the private weather service Weather Underground says that means less wind and rainfall on land.
Even so, he said winds could still gust to 50 mph in New York and New Jersey Wednesday afternoon and evening.
Storm surges along the coasts of New Jersey and New York Wednesday afternoon are expected to reach perhaps 3 feet.
Copyright 2014 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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MONDAY, JANUARY 24 Arrival day for personal activities in St. Louis, a cosmopolitan Mississippi River destination where visitors quickly learn "there's more than meets the arch." TUESDAY, JANUARY 25 8 a.m. Behind-the-Scenes Experience (Advance registration required) Immerse yourself in the inner operations of a creative advertising company, public relations firm, hotel, or major convention center. Gain hands-on experience as you become involved with key personnel in a range of ...
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This Is March Madness All RightThursday, March 21, 2013
It's called March Madness, and fans of college basketball understand why when they fill out (then mark up or tear up and redo) their brackets. Inevitably there will be upsets. Which No. 12 seed will "shock" a No. 5 this time around? It seems to happen almost every year. Which top-seed will fall? And when?


text: Part of Studio Enterprise Studio for Silverlight Home XAML Studio for Silverlight Studio OverviewFeaturesControls IncludedResourcesWhat's New Live Demos Pricing Download Free Trial Uninstall EULA ActiveReports 9 Developer For Development teams requiring rich embedded reporting in their .NET applications. Download ActiveReports 9 Server Add-on For development teams with the need to publish and integrate complex reporting with enterprise grade scalable server technology. Download 60+ Powerful Silverlight Controls for Modern Business Applications Inside ComponentOne Studio® for Silverlight you'll find the right tool for the right job. The studio comes packed with over 60 UI controls and libraries you need to shorten your development cycle and create modern Web and desktop applications for today and tomorrow. These powerful, yet lightweight, controls include fast grids, powerful charts, and professional themes that are easy to plug into your applications. Interested in migrating your Silverlight apps to HTML5/JavaScript? Check out ComponentOne CTO Bernardo de Castilho's new white paper to learn how. Silverlight at-a-glance 60+ controls and libraries 17 themes including Office 2013 Localized Resources for 20+ cultures Silverlight 4 and 5 support Visual Studio 2013 and Expression Blend Gesture and multi-touch support MVVM and UI automation (UIA) support Features & Highlights Stunning and Superior Data Visualization With 40+ chart types, flexible data binding, optimization for large data sets, and so many extensibility points, C1Chart is a powerful control you need in your toolbox. Top financial and professional service companies prefer C1Chart for their data visualization needs. We have you covered when it comes to 3D surface charts too with C1Chart3D. And bring your geographic dashboards to life with C1Maps, a live map viewer with vector and UI element layers for simplified visualizations. Chart Chart3D Maps Load Large Data with the Fastest Grid Experience the FlexGrid's legendary flexibility, speed, and small footprint. Inspired by Microsoft Excel for creating bound and unbound grids and scrolling speed 10x faster than the competition, C1FlexGrid provides built-in printing, cell merging, column aggregation, custom cells, and all the extensibility you need for your business data. With our innovative, server-side Virtual Mode technology you can navigate through infinitely large data sets asynchronously while scrolling. FlexGrid Entity Framework DataSource First-class Support for Popular Formats: PDF, HTML Get complete support for reading and writing HTML and PDF content in Silverlight with many of our controls. View your PDF documents and HTML reports using our innovative C1PdfViewer and C1ReportViewer controls. Export your data and create PDFs with ease using our C1Pdf library. Display Web pages in all of your apps with C1HtmlHost and deliver complete HTML and RTF editing with our Microsoft Word-like C1RichTextBox control. PdfViewer Pdf Library RichTextBox HtmlHost Out of the Box Scheduling Solutions Create a complete appointment or event scheduling application in minutes with our C1Schedule and C1Calendar controls. C1Scheduler can be easily tailored to fit any data model and gives you five built-in appointment views: day, week, work week, month and time line. Bind your schedule to the data source of your choice, use local XML storage or import/export iCal data. Scheduler Calendar 17 Complete, Professional Themes Get 17 themes including Modern UI and Office 2013 for the entire studio. These complete themes not only style ComponentOne controls but the standard ones too. So you can deliver a professionally designed theme for your entire application in just seconds. 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All licenses are developer-based and there are no limits on the distribution of applications–unlimited, royalty-free, run-time distribution. Pricing Need help deciding? Chat with sales, call or email. We're here to answer all your questions. 1.800.858.2739 | 412.681.4343 email@example.com Chat with Sales


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Bikram Yoga Belgrade is the first official and authorized studio of Bikram Yoga in Serbia. Thanks to a couple of Serbian enthusiasts, Bikram Yoga finally made its way to Belgrade.
Initially classes will be held only in English and instructors will be from abroad, since there are not enough authorized Bikram Yoga instructors in the country. Conditions for an instructor license are 6 months of practice in an authorized studio, letter of recommendation from a qualified instructor and 2 months teacher training in California. These facts as well as a high cost of maintaining ideal temperature and humidity justify the class price, which is still considerably lower than in Western Europe.
We hope that you will be satisfied and that Bikram Yoga will change your life just as it influenced lives of many students throughout the world. If your travel brings you often to major capital cities (and almost all cities in the US) keep in mind that you are always welcome to any Bikram Yoga studio. No need to bring stuff with you – a minimal yoga attire is sufficient.
More information about Bikram Yoga you can find on the official Bikram website. Here is the essence:
- 90 minutes, 26 yoga postures at 42° C;
- Bikram Yoga is not just relaxation and meditation, but also a serious physical training;
- Mind is pushed to maintain inner discipline and the whole body is stretching, tightening and strengthening;
- All the joints are activated and the whole body is freed from toxins;
- A major help in weight control;
- Strengthens the immune system;
- Strengthens joints, bones and muscles;
- Improves mental focus;
- Cures insomnia;
- Anti-stress and anti-fatigue;
- Improves the posture of the whole body;
- Rejuvenates and charges you with energy!


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|allostery platform
|business strategy
Dipraglurant-IR for Parkinson's disease levodopa-induced dyskinesia
Dipraglurant is a novel oral small molecule, which inhibits the metabotropic glutamate receptor 5 (mGluR5), and has potential to be used in combination with levodopa or dopamine agonists for treatment of Parkinson's disease (PD). Our initial focus is on testing dipraglurant for the treatment of PD levodopa-induced dyskinesia (PD-LID). Together with a partner, we hope to study dipraglurant's potential for treatment of the non-motor symptoms of PD (e.g. anxiety, depression and impulse control disorders), motor symptoms of PD and also non-parkinsonian dystonias.
During the neurodegenerative process of PD, loss of striatal dopaminergic neurons results in an increase in gluatamatergic output from the substantia nigra. mGluR5 are abundant in the striatum and implicated in the excess glutamate activity observed in PD. Blockade of mGluR5 has been shown to have anti-PD and antidyskinetic effects in a variety of animal models as well as early trials in patients.
We believe a successful treatment for PD-LID will change the way Parkinson's disease is treated, by enabling physicians to use the most effective drug for Parkinson's disease – levodopa – earlier and more aggressively. In addition, based on robust preclinical data, potential label expansions for dipraglurant include: PD motor symptoms and/or non-motor symptoms, like co-morbid anxiety and depression, as well as non-parkinsonian dystonias.
We recently reported data from a double-blind, placebo-controlled, EU and U.S. trial of dipraglurant in 72 PD-LID patients, the primary objective being safety and tolerability. In addition, the trial was designed to evaluate exploratory efficacy as a secondary objective. Efficacy is being measured using: the modified Abnormal Involuntary Movement Scale; patient diaries documenting on time (with/without dyskinesias), off time and sleep time; the Unified Parkinson's Disease Rating Scale; the Clinician & Patient Global Impression of Change; and finally, an evaluation of the patients' mood, using the Hospital Anxiety & Depression Score.
Full data from the study, which is partially funded by a grant from The Michael J Fox Foundation for Parkinson's Research, will be presented at a conference later this year. The Michael J. Fox Foundation Blog posted a commentary on our Phase IIa top line data.
While dipraglurant has broad potential for treating Parkinson's and other diseases, the most direct path to market is treatment of PD-LID. No drug is approved for PD-LID and LID has been identified by the regulatory authorities, patient advocacy groups such as Michael J. Fox Foundation and key opinion leaders as a very important unmet medical need. The potential market opportunity for dipraglurant in Parkinson's disease is well in excess of $1 billion, according to market research carried out by Datamonitor for Addex. Further label expansion outside of Parkinson's disease, for example to treat non-parkinsonian dystonias, could more than double the peak sales potential for dipraglurant.
As a result, we think that dipraglurant is a compelling partnering opportunity. We are seeking a partner with the vision, expertise and capability to fully exploit dipraglurant's attractive commercial potential. With the Phase IIa data for dipraglurant-IR in hand, we now plan to engage in partnership discussions with a view towards having a partner on board before the end of 2012.
"Our Phase IIa data for dipraglurant are positive and we are pleased to have demonstrated robust proof of concept in PD-LID. Both dipraglurant doses had a good safety and tolerability profile and demonstrated efficacy. The increase in on-time without dyskinesia, combined with the decrease in off-time observed during week 4, is encouraging, and warrants further evaluation. It's particularly promising that the significant reduction in dyskinesia severity on the mAIMS was mirrored by a reduction in patient reported dyskinesia time and that both clinicians and patients favoured dipraglurant over placebo." - Charlotte Keywood, CMO


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Health Information - Med Help
My MedHelp
Eye swollen shut child
Common Questions and Answers about Eye swollen shut child
When the
the brain was not getting an image from that
and it could have drifted out of line because of the phoria. When the swelling went down the eyes are no longer straight so the child sees double. if this is the cause (and there are others but this is most most common) and there is no family history of eye muscle problems the brain usually realigns and fuses the double vision within 24-48 hrs.
Read More
9 F and his right eye was
and had blue and red bruises on the
lid and under the
he had also red patches on his legs and hands with small white dots which were itching. I went to the ER and by then the red patches went away almost completely but the eye looked worse, they assumed it was an allergy and gave him Benadryl. That didn't work, the next morning when he woke up and his eye was shut completely I went to a Dr.
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My daughter woke up 4 days ago with her right
. It hurt, and worse if I touched it. Toward the outside and about a 1/4 of an inch up on the outside of her eyelid was what looked like the center of the problem, red and raised to an oblong slight bump. I gave her some benadryl in case it was a cat hair or something she was allergic to. The swelling reduced by the afternoon and I was able to pull up on the eyelid to see a patch of white bumps that looked like small herpes blisters.
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yesterday i noticed that his right
and then today when he woke up both were.we just moved to an area that has poison oak on the property. and last month he was diagnosed diabetic.. and only his eyes are swollen . and i can tell it's bothering him. so if anyone has any suggestion or solutions or a reason as to way this is happening please respond. he is my life. the child i couldn't have. so i don't know if this a allergic reaction to poison oak of some other type of allergy.
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My son also gets
eyes. It only happens when he is sick. The doctors think he is allergic to omnicef so stopped giving it to him. Today it happened after he took motrin. I took him to urgent care and they gave him a antibotic in the omnicef family even though o told them several times he was allergic to it. Thank god I called his regular ped doc before I gave it to him. Doesn't explain why his eyes were swollen to begin with though.
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i thought she must have hit it on her crib or gotten bit. thismorning it was completely
. i assume it is a bug/spider bite. what can i safely draw the venom out with, being that it is on her eye. does a bite in this area pose a greater risk to her vision or brain.
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He said that if the new eye drops didn't kick in within 24 hours she needs to go see an
Dr. My poor girl.....she is miserable! Both of her eyes are practicaly
. Thanks everybody!
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But his little nose is almost completely
on one side and it is so raw and bloody he can't stand for it to be touched. He is also having a darker discharge from his nose. Also he is getting bumps on his face that are painful and his little mouth is covered in blisters. Does anyone have any idea what this could be? Now my oldest son, who is 9, has started running a fever. Please help!!
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By Thanksgiving, my eyes had gone from being bloodshot and puffy to
. My doctor prescribed steroids. Within 3 days of stopping 2 separate round of steroids (which did help all the allergy symptoms and swelling), my swollen sensitive eyes would start up again and then my mouth broke out in terrible cold sores. I've had larger ones on my bottom lip since a child. But these are completely different. Tiny little blisters along my top lip and the skin around my lips. Gross.
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While out for a run over the weekend, I noticed my left
. I thought that perhaps I got something in it and continued on my run. Soon I had to cut my run short and noticed my tounge was swelling as well. My wife happened to be driving home and saw my face. She thought I had fallen and wanted to take me to the urgent care center in town. I felt that perhaps I was just a bit dehydrated until I saw my face in the mirror. It turns out I was having an alergic reaction to something.
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My SO had the swollen lip,
face, and peeling skin issue for about 3 months. We went from doctor to doctor and everyone doled out the Prednisone- which worked while he took them, BUT once he stopped, he'd swell up again. We tried everything, herbal remedies, food diary, restricting suspected foods and changing soaps/detergents. Then we went to an allergy doctor who did some testing and nothing was found.
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couple of days ago we noticed what looked like a sty on the top lid of my Bug s
. Tonight the
was almost
. . I plan to take her to the vet tomorrow. No one spoke of swelling with a possible sty. She doesn t seem bothered by it at all.
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Througout the day I have to wash out eyes, out my fingers in eye to remove the stuff- I know this can't be good but it happens so often I have to. It is clear, and runs in the bottom of
, on
, top of inside
, long stringy goo. I can lightly wet a cutip- put in inside corner of eye and spin. The stuff goes from top to bottom. It is such an irritant. What could this be- I went to dr before and they said it was allergies. All the time I dont think so.
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), I found that that evening my eye was itchy. The next morning my upper
lid along my
lashes was red and
. No
make up or contacts here. I also do not have dry skin near my eye at all. And I have never had any problems with allergies. I want to rub the heck out of it and am trying to refrain. I'm not sure that this is the same as everyone else but just thought I'd add in case anyone has any ideas for me.
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My granddaughter was bitten on the bridge of her nose by a mosquito that left her eye
the next morning, her mother took her to the doctor who gave her benedryl. Her
is not swollen anymore bout the pimple is still there and turns really red and purple randomly. This happened over a week ago. Can you give me a reason for this?
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This morning, he awoke, and 1 eye is nearly swelled
; the other is
as well. His face looks about as red as it did yesterday. He isn't complaining of any other symptoms though he's uncomfortable and not as active as usual. I don't see any rash. He's not eaten any shellfish. He takes Concerta for ADD and is allergic to cats. Not other known allergies. We've given him Benedryl and he's keeping a cold compress on the worst eye. Can you suggest a diagnosis? Treatment?
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the doctor at my local ER gave it to me when i went in there one time with my
competly from eating peanuts which will cause these whelps.. i hope this helps you out and god bless for being such a good parent to really find out what is going on with your child i dont know for sure this is what she may have but it is a suggestion.
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She had her first facial swelling at 11 months old, woke up one morning and her
! Even since then she has it on and off and she is now 18 months old. We have been to see lots of docs and lots of tests have been done but non of them have got a clue! she now wakes up with swollen eyes, lips, cheeks and once she woke up with a swollen forehead :( I have changed all the normal things like washing powder, cleaning products, even changed all of her bedding.
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My pupils are different sizes and when I wake up in the morning my right
is almost
. I had a nornal thyroid test. I had one stool test for C-diff, and one for giardia and both were negative. I thought maybe yeast from the antibiotics (because when I get it, I get it bad) but the diarrhea is very foul. Also I have what looks like oral thrush that hasn't cleared with Nystatin or diflucan.
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March 28, 2007 - Woke up with left
, photophobic, tearing. Right
was just a little
. Local opthamologist who diagnosed a corneal abrasion of her left eye. Prescribed antibiotic eye drops every 2 hours and eye ointment (antibiotic) at night. March 29, 2007 - I noticed a grayish white blister on her left eye when I was putting the eye drops in. Local opthamologist who told me to increase the drops to q1h.
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some nights its not so bad where i dont do it or do it as much and then other times, its for hours, and there been times were my fiance woke me up and said i was sitting up picking my eyes, he thought i was awake, i was sleeping! and when i woke up my whole face was puffy, and my eyes were so
and crusted
, and it hurts so bad, that only happened twice, but it scares me, and why cant i stop?
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kind of creepy thinking peoples' eyes just snap
like that! How very odd! Mine is rather more that my
won't open unless I coax it, stubborn thing! How did you pull that one out of the air like that? I'm impressed. Will keep it in mind. I'm sure it's all related, don't you think? Thanks so much! ess~ You're one of the sagest people I know! Please! Yes, I think I hurt my eye or lid. It smarts. Youch!
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when he wakes up from a nap or sleep his eyelashes are half matted shut and i have to take a hot washcloth to fix them. Im assumign he has an
infection from the cold and will need
drops for this. We have no health insurance and Im wondering how much this might cost. If anyone has any idea that would be great. Im fretting already because Im sure the Dr will send them home with a fistfull of RXs each. UGH this sucksss!!!!
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When I was 28 years old, I had a terrible outbreak of shingles on the right side of my face, up into my head and down to my eyelid. It swoll my
. I had a horrendous headache with it. I told that doctor that I'd never had chickenpox before and he argued with me. He said that I could have had an extremely mild case of them like 2 bumps on bottom of my feet, or something and that it would be enough for me to get shingles later. My sister that I was growing up with (14 mon.
Read More
I have them on my lips, in my mouth, on my cheek, on my forehead, on my nose, on my eye and in my eye, all on the left side of my face. And the whole side of my face is so
that my left
is almost
. I am on medication for the shingles and drops for my eye. It has all been pretty pinful but my trusty vicodens have helped alot. My mom stopped by today and told me that I was begining to look much better.
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lost alot of good pictures of him drooling and the picture of my eyelid he busted open. My
, black and blue. I had to be sewn up by a plastic surgeon. I think that's the part that made me the most angry, is that he burned that picture. But, I still have the scar to prove it I guess. Maybe some hospital records also? It's all so frustrating I know.. I have bags under my eyes and I feel I'm too young for that.
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When you see your doctor, throat redness and irritation and
glands are noted, confirming even further that you're in the middle of a standard upper respiratory infection, or the common cold. Typically, it'll last anywhere from 3-5 days. A small minority will progress into one of the classic complications of a common cold, such as a bronchitis or sinusitis.
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In the winter time i get dry cracked eyelids, and its because my eyes water alot, but now its Summer time, and for some reason I have had cracked swollen itchy eye lids mostly in the corners towards the nose area. I have tryed A & D, Hydrocortisone cream, Blistex, moisturizers, Vaseline, I have had this for almost 4 weeks now, crazy.
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i need to steam clean my carpets. and now i want to buy buy buy lol. i have my
on a pair of sandels (like i can afford to buy them) at macys, i figure if i cant look good in clothes, there are always shoes and purses!! lol. i finally went and bought a pair of shorts and a dress in a size bigger. ive gained 2 pounds, but nothing is fitting anymore!!! egads, im going to be one large mama!!
Read More
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When Design Professor Judith Aronson was asked to exhibit photographs from her new book Likenesses at one of the great Oxford Colleges, Christ Church, she met the request with stunned elation.
"The Christ Church gallery is where you find one of the most important private collections of art in the UK. When I was invited to show, I couldn't believe it," said Aronson.
She then paused briefly to consider any conflicts with the start of her semester at Simmons College, to which her husband said: "You must do it, Judith. When you are invited to show at Christ Church, there is no question."
Continue reading Likenesses by Judith Aronson.
On Saturday, Oct. 9, the Communications Department at Simmons College will again host the Intercollegiate Broadcasting System (IBS) East Coast Radio and Webcasting Conference. The 7th Annual East Coast Radio/Webcast Conference runs from 9:00 - 5:00 and features more than 20 workshops and seminars on media skills and issues.
The Communications department is excited that this year our faculty will give a presentation on an excited new virtual student abroad radio course. We live in a Global society. More and more, the world is being tied together through international commerce, trade, communications systems that span the globe in an instant and increased social contact between societies.
Continue reading Intercollegiate Broadcasting System Conference 2010.


text:
Although normally I love the week between Christmas and New Year's the most--this Christmas season the build-up to this week, with the days ticking away to the big day has been wonderful. I am really happy that we chose to wait until just over a week ago to really decorate. Everything is still fresh and ready---although I went a bit overboard on the live 'mini-evergreens' and I am schlepping them upstairs to the bathtub every few days for a nice damp 'shower'....I have so many that just using the kitchen sink is not an option.
We had a family dinner on Sunday to invite 'Belle Niece' and her handsome (I can say that because he is like my nephew--right?) 'mari'....who we will miss seeing at Christmas because we are l-e-a-v-i-n-g town! Yes! We are getting out of Dodge (or Basse Normandie!) for Christmas and going down to French Guy's sisters house (actually it is a CASTLE....I kid you not!) to spend time with them and we are taking my 'cher-in-laws' too! A big family road trip and I couldn't be more excited. They live between Dijon and Lyon--just to give you a reference point and I am thrilled to be going to their home again! Last time we visited I was not yet an 'immigrant'--we were on vacation and Oldest Garcon (aka 'the teen') was only 9 months old---so yes, that long ago! It should be really fun and amazing! I can't wait! (Did I say that already?!) We have to take a van because it is our family (us and the 'trois enfants' and French Guy's parents and then..... in a crazy moment of insanity we decided we will also take the three doggies... (easier than boarding or getting a sitter) so it should be well an 'interesting' 7 hour drive.....you will want to stay tuned!
On Friday-- we heard the news from thousands of miles away of the unspeakable tragedy in CT. News does take time to get over to us in France normally--but 'thanks' in part to things like Facebook--it sometimes travels very fast and it was within 30 minutes of the breaking news that I was aware of the story. There are no words. Coming from a girl that is never at a loss for words normally...
.....no words.
Our weekend, I am sure like most of you, passed with heavy hearts. Saturday morning I woke up and looked at my three children in awe and amazement of how incredibly blessed I am. A simple moment, the three of them in our 'veranda' sitting eating breakfast in their PJ's.... content and safe. I could have stood and starred at them for the rest of the day ..... weekend.
After this weekend we are feeling the joy and of Christmas slowly seeping back to us and our hearts over-flow with gratitude while we hug more often, love harder and pray for those whose arms are emptier with hopes that we can go on to make a difference, make decisions and efforts with renewed intent and wisdom and prevent this from ever happening again---anywhere.
French Guy and I are having a Christmas shopping date on Wednesday-- going to wrap up the gift buying for the kids (yes even the one the remains on the naughty-list as mentioned previously--although I am tempted to stop by 'Coals-R-Us' for that one!) I know this week is going to fly by like Dasher and Dancer! I am taking a break from the shop and won't be shipping until after the 28th of December. A sincere 'Merci' for a wonderful season--for your on-going support and kindness!
Trying to do one more post before the weekend---then I am outta here!
Until then---Have a great week mes amis!


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Originally a home-recording
project, Mantler (Chris A. Cummings) has
in recent years become a regular presence on the Toronto live music
scene. Playing a wurlitzer electric piano accompanied by a 1970s
Rhythm Ace drum machine, Mantler has made many fans among Toronto's
music community.
Beginning with the longer, moody songs of 2000's DOIN' IT ALL, released on James Duncan's Le Systeme label, and continuing through 2002's SADISFACTION, the first Mantler album to be released on Germany's Tomlab label, Cummings sought to impose tighter controls over his song structures, culminating in LANDAU (Tomlab, 2004), which also marked his first usage of programmed beats and interlocking parts, and was also the first Mantler album to be completely produced by longtime associate Zack G.
LANDAU was rated #15 on Rolling Stone Germany's Critic's Chart in 2004.
The new Mantler album MONODY, co-produced by Zack G, Jeremy Greenspan (Junior Boys) and Leon Taheny (Final Fantasy), will be released by Tomlab and Tin Angel.
In addition to playing live regularly in Toronto, Cummings made short solo tours of Italy and Germany in 2004, and also toured Europe and the UK in 2007 opening for Constellation artist Sandro Perri (Polmo Polpo).


text:
Talk to Me
Tera Los Angeles
Tyler, I commend you for your stand and your heart to bring healing to a community/my community that has been hit by divorce, abuse, drugs, neglect and the like! But I'm not sure I agree with you keeping Kim Kardashian in your movie. I don't beleive she married for love, nor do I think she cares about anyone other than herself. Is there hope for all? Yes. Should she be given a chance? Yes. But I also believe this might be a good opportunity for her to realize that you can't do people and marriage any kind of way. Maybe a slow d** from the top will bring her back to reality! Of course you will do what you want, but be ready if your fans don't like the decision you make! ~TeraReply
caz #1577880
My issue with you casting her isn't the fact that she got divorced after 72 days, it's the reason you gave for it. You stated that "young people" look up to her and "people line up around the block to get in her store". When you say " young people" who your really referring to young white girls. It almost comes off insulting as if black women should be glad to have a role model like Kim. Your target demographic has NOTHING in common with this woman. Her background, her lifestyle, her explicit claim to fame seem to go against everything your image and movies stood for...until now. I'm sure you have your reasons but don't expect your audience to truly understand or support your decision to cast an amateur p*** star/celebutant in your movie. All I can think of are the talented young black actresses who study acting and work at their craft and would love to have even a small part in a Tyler Perry movie, but they lose again to those with a famous name, no training, experience in the craft, or talent. I hate to think that your motivation is money or box office position, I simply think you may be trying to reach a different audience however, this was a truly bad decision. My support for you is fading...Reply
Confused fan #1578047
I always take my now ten years old daughter and little cousins to see your movies EVERYTIME IT COMES OUT. I won't be doing it with this one. She and her entire family are No ROLE MODELS FOR ANYONE IN THEIR RIGHT MIND. I love your work and will cont to support you, just not this time. Stay blessedReply
pissed north carolina #1579023
i'm sorry Mr. Perry, Kim is no role model just like all the other girls on reality tv. if you had to pick someone, you could have picked LaLa Anthony. Alot of people thinks her reality tv show is boring but i like it because its not alot of b**ch, f**you, suck my d**k, etc. I don't understand the relationship that kim and her sisters have with their mother and bruce but it works for them for whatever disrespectful reason but not me. These young girls today are easily swayed and impressed with this mess on tv. Like young boys are impressed with the rappers showing the bling and 24s on their cars. Be careful who you(you in general) call a role model. It's your show do with it what you want to do but I think you could have picked someone else. MY VOTE WAS LALA ANTHONY, OR THE YOUNGEST SISTER FROM THE "FRESH PRINCE". MS. TYTANIA ALI(SORRY IF THATS SPELLED WRONG, PEOPLE KNOW WHO I'M TALKING ABOUT. GOOD LUCK, SIR!!!Reply
TYLER PERRY YOU ARE QUITE CONFUSED AND ITS APPARENT YOU HAVE BEEN MISINFORMED BAMBOOZLED AND LED ASTRAY WHEN YOU HAVE THE AUDACITY TO SAY THAT KIM KARDASHIAN IS A ROLE MODEL. FIRST OF ALL SHAME ON THE PARENTS THAT LET THEIR CHILDREN WATCH THE KARDASHIANS IN THE FIRST PLACE. THIS CHICK SLEEPS WITH EVERYBODY WHERE I COME FROM THAT IS CALLED A S*** BUT IN HOLLYWOOD ITS THE NORM. GO FIGURE. THERE ARE SO MANY AND WELL TRAINED BLACK ACTORS AND BLACK LATINOS ACTORS THAT HAVE PAID THEIR DUES AND ARE STILL PAYING THEIR DUES THATS WHO YOU SHOULD HAVE GIVEN THE ROLE TO. EVENTHOUGH YOU SAY ITS NOT A LEAD ROLE ITS STILL A ROLE THAT SHOULD HAVE WENT TO SOMEBODY THAT CAN ACT. POOR CHOICE HOPE THIS DECISION DOES NOT COME BACK TO B*** YOU IN THE ASS. BUT THEN AGAIN ITS YOUR MOVIE AND YOU CAN PUT WHOMEVER YOU WANT IN IT BUT I ALSO HAVE THE CHOICE OF NOT SUPPORTING THE MOVIE. STILL LIKE YOUR MOVIES AND PLAYS BUT NOT THIS TIME I WILL WATCH Y OUR MOVIE WHEN ITS AVAILABLE ON BOOTLEG AND I HAVE PAID TO WATCH YOUR MOVIES IN THE THEATRE BUT NOT THIS TIME. MAYBE YOU HAVE BECOME TOO HIGH AND MIGHTY NOW TO CARE WHAT YOUR FANS THINK ABOUT YOU BUT REMEMBER THE BLACK FANS ARE THE ONE WHO MADE YOU GET TO WHERE YOU ARE TODAY. WE WERE THE ONES GOING TO THE BEACON THEATRE TO WATCH YOUR PLAYS AT A FAIR PRICE NOW I CANT EVEN AFFORD A SEAT AT THE BEACON TO SEE THE LAST PLAY YOU HAD OUT BECAUSE THEY ARE NOT AFFORDABLE ANYMORE TO THE PEOPLE WHO MADE YOU THE SUCCESS YOU ARE TODAY. JUST KEEP THAT IN MIND WHAT GOES UP CAN COME RIGHT BACK DOWN. THE UNIVERSE WILL DEAL WITH YOU ON THAT ONEReply
sandra Atlanta #1585630
CeCi please get a life ! Tyler Pery dont own u or anyone anything.Thats the problem with some in this world people actually think they are own something. You sound bitter and cold why dont u use your brain and get your own studio.notReply
@SANDRA SO SORRY U FEEL THIS WAY BUT UNLIKE U I DO HAVE A LIFE AND ITS TO TELL THE TRUTH I'M NEITHER COLD NOR BITTER TYLER PERRY DOES NOT OWE ME ANYTHING AND HE CAN PUT WHOMEVER HE WANTS DID U NOT READ WHAT I SAID THATS THE PROBLEM WITH SOME PEOPLE THEY CANT COMPREHEND WHAT THEY READ EVERYBODY IS ENTITLED TO THEIR OWN OPINION AND I HAVE SAID MINE AND YOU HAVE SAID YOURS AND NOW I WISH YOU A GOOD NIGHTReply
KIM Florence, SC #1593698
CeCi you said it. But not to mention Zoe Saldena, Kerry Washington,Nia Long, Gabriel Union, Regina King and others Kirsten Dunst, Jessica Alba and Amanda Stewart. Sandy try reading and understanding before you commentReply
Jonna Atlanta #1626209
I do agree with this statement, I'm definetly a hard working actress who can't even s*** through for an audition to show my craft because of the fame characters that are continuously popping up in your films & television shows! I think all the bad famous actors are going to eventually loose you the genuine audiences you once had follow you. I know personally my family both the whit side & the black side has stopped supporting your productions due to big named bad actors. We used to make it a whole church event to go see your plays in theatre before you had the TV shows, but not anymore. I just wish you would s**** to what you've been known for..... using real good actors to potray the real good messages. I'm sorry, but actresses in the Meet the Browns I've met, I won't say any names but are surprised that I havent auditioned with you. Or interested in my personality. I just think the audition process should be re-evaluated on what legacy you are truley trying to leave behind for future directors.Reply
elizabeth wells jacksonville,n.c.28540 #1703290
i think u are getting his messages mixed up , he shows us through his comedy to love one another and to love God and trust in him. color doesn't have a damned thing to do with it , we are all in God's Big box of crayons, and it takes ALL colors to make a beautiful picture , if u don't believe me , look at a rainbow. if your support for tyler is fadding u were never a true fan any way. Getta steppin , follow someone who believes in what u do , one more thing God created all of us and everyone deserves a chance. only God judges and he hadn't done it yet , when we die is when he passes his judgment, i don't want to be in your shoes . it's not a all one color Heaven , we will all be there to praise his name and rejoice with him , i hope to see you there. i will pray for you till then. Good luck.Reply


text:
Testroll LC-Wide
I got a brand new LC-Wide! I saved all my piggies for this and finally it was delivered! I had problems getting used to the ultra wide angle, so many shots with my fingers on it ;-))This photo was shot on film. Taken by moodification with a Lomo LC-Wide (available in our Online Shop) loaded with Fuji Sensia 200 film in Düsseldorf, Germany. These tags describe this photo: expired, lc-w, sensia 200, x-pro, cross, wide angle, testroll, kaiserswerth, and düsseldorf. Date: 2012-04-12. Time: Afternoon. This photo can also be found in the album Testroll LC-Wide - April 2012.
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Avenue des Bains, 59140, Dunkerque, France
Visit the Jardin De Sculptures Musee D'Art Contemporain website
The reviews and ratings originate in all cases from third parties. Gardenvisit is in no case responsible for the correctness or accuracy of the reviews. Reviews and similar information are not an expression of Gardenvisit's opinions.


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Matrix Aviation, Inc.1701 S. Hoover Rd.
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Phone: 316/942-0844
Fax: 316/942-0891
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Website: www.matrixaviation.com
Matrix Aviation, Inc. is a stocking distributor of aircraft avionics, instruments and components offering sales, support, rental and exchange. The company also engages in the purchase of surplus equipment as well as consignment sales of customer equipment. Matrix Aviation, Inc. offers 24-hour a day, 365 days a year around the clock A.O.G.support. A.O.G. services hotline for around the clock uspport
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With its interesting brew of Malay, Chinese, Indian, indigenous and Western cultures, KL is a lively city. Whether it is your first time here or you're a frequent visitor, check out KL Magazine for the best tips and advice.
While others visit Petronas Towers and Petaling Street, we will point you in the direction of the best places to eat, shop, sleep and see. We review only the best and bring you back stage passes to club openings, unique attractions and the tastiest restaurants in town. Whether it is a quirky Korean dessert café, a trendy boutique hotel or an exclusive rooftop bar, this guide is sure to make your KL experience unique.
Help us keep this website up-to-date by sending us your comments and suggestions. If your question is about a hotel please use this link - For TOUR questions and enquiries please use this link
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HOME Soccer Seattle Sounders FC Gear Seattle Sounders FC Ladies Seattle Sounders FC Ladies Accessories (11 items) Product ID: 1714927
Main Content
You have a paper due tomorrow, but you've got writer's block. Invigorate your imagination with this Seattle Sounders Keyscapes wireless keyboard! Covered in vibrant Seattle graphics, this festive keyboard is bursting with spirit. It features low-set keys for easy typing and a 10-key number pad for swift number crunching. With this cool Sounders keyboard, you'll crank that paper out in no time!
- 1-Year manufacturer's warranty
- Easy Plug & Play connection
- Function keys (for Mac & Windows)
- Imported
- Low-set keys for comfortable typing
- Mac compatibility: OSX 10.0 and later
- Measures approximately 0.75'' x 6.75'' x 18''
- Numeric 10-keypad for crunching numbers
- Officially licensed
- Printed graphics
- USB 2.0 connection
- Uses 2 AAA batteries (included)
- Windows compatibility: Windows 7, Vista & XP
- Wireless keyboard
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Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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money - Page 2
Lucky Cashier Sells Herself Winning $1 Million Powerball Ticket — One Week After Another Win!
Rich Parents Are Using Handicapped Tour Guides to Avoid Lines at Disney World
New $100 Bills Coming in October
Major League Baseball Ticket Prices Are Going Up, But They're Still a Bargain
The Most Ridiculous Around-the-World Adventure Can Be Yours — For a Very Hefty $1.2 Million
Waiter Who Defended Boy With Down Syndrome Gives All Donations To Charity
Last month, Michael Garcia made a lot of people smile. The 45-year-old, who is a waiter at Laurenzo's Restaurant in Houston, Texas, refused to serve a family who insulted Milo Castillo, a five-year-old with Down Syndrome, by suggesting that "special needs children need to be special someplace else."
5 Ways to Save Money on Your 2013 Taxes
It's hard to believe it's already the middle of tax season. 2013 is off to a fast clip, and unfortunately this means that Tax Day is right around the corner. You could bury your head in the sand until you hit April 14 panic mode, or this year you could give yourself a burst of energy and self-confidence knowing that you met your taxes head-on. Here are money savers to get you started:


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When I first came to Barton, I was surprised to learn that there wasn't a Mass Communications Club for us mass communication majors. Well, I took the initiative to start the club. Two of my friends and I, who are also mass communication majors, took the idea to the Director of Student Activities, and she …
Tag Archive: mass communications
Apr 18
New Club on Campus!
Apr 07
Mass Communications
I'm a mass communications major with a concentration in journalism and public relations, and I have to say that I LOVE IT! One of my favorite things to do is to write, so that makes journalism and public relations the perfect major for me. The mass communications department at Barton is smaller than some of …


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"This is such a fun dessert! I made these a few days ahead of time for a dinner party of 10. I used home made brandied chocolate covered cherries for the treat inside. I rolled them in the cookie/chocolate mixture and then froze them. When it was time to serve, I just heated the caramel sauce. Super easy and everyone absolutely loved them. Wh"
"I made these ahead of time so I could enjoy the party. I grilled them inside and refrigerated until ready. Very good - something a little different!"
"I made this recipe as written and it was fabulous - I did cut down on the salt, however. I was havinig a dinner party on Sunday so I started the process on Saturday. I baked the ribs for l-l/2 hours on Sat. and finished the cooking on Sunday. Even the picky eaters loved it."


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Possible district foe takes down baseball Cats
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Wildcat batters were stymied by Conway pitching in an 8-1 defeat the Cats suffered on the road last week. It was only the second loss of the year for the Cuba baseball team.
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Which leads us to. . .exercise. Yes, the "e" word. Recently both the Surgeon General and Health and Human Services Director recommended that adults should engage in moderate physical activity for at least 30 minutes a day.
The good news: Researchers have discovered that those 30 minutes of exercise can be broken up into 10-minute intervals. So even if you're short on time, you don't have to short-change yourself when it comes to getting fit. For example, suppose you need to mail a letter. Check your watch. Now walk briskly to the nearest mailbox and, if you need more exercise to accumulate those 10 minutes, walk all the way around the block to return.
Enjoy watching the evening news? Go ahead-but jump rope during every commercial break. Or invest in a stationary bike and exercise your heart and mind at the same time.
Annaliese Furnas succeeds in meeting her goal of taking daily exercise breaks by planning them into her day. Her tip: "I usually set a kitchen timer and place it in the room right outside my home office so I have to get up to turn it off. That's a trigger for me to go for a walk or pop an exercise tape in the VCR."
Another homebased entrepreneur, Becky Bace, runs her own network security consulting company, Infidel Inc., from the Scotts Valley, California, home she shares with her business partner, Terri Gilbert. Her tip for incorporating exercise into a busy day? Get a dog or live in an area where you have easy access to attractive walking areas-Bace takes walks in a nearby redwood forest or drives to Santa Cruz's seaside walking paths.
"Our dog [a 13-year old Border Collie] is insistent about taking periodic walks. Of course, the fact that we live in [an area with] stunning surroundings and good weather helps a lot, too," says Bace, 45, who moved to California two years ago and uses her family home in Baltimore as an East Coast base. "It was much harder to get myself to exercise in Baltimore, where the weather was often too hot or cold for comfort. There are days when I skip exercising-for instance, when I have client meetings or conference appearances-and I invariably feel worse."


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More, please.
love the videos where she keeps saying over and over "your a dirty boy."
Aww she so cute. Too bad all the vids that actually features her were removed. Now there's just this vid with another shemale with the same first name but it's not the actual Neveah Sky...
Absolutely love her pics wearing glasses. The nerdy look is sooo hot for her!
She's One Badd Bitch :)
tremenda puta!! me gustaria romperle bien el orto con mi pija y despues metercela por la boca hasta la garganta!! hacerla mi esclava sexual
One of the best girls in the world!
Perfekt Girl.
Sweet Cheekpiercing.
I Love she.
love your eyes, I would love a date, but would settle for more to see and some mail...your the best I;ve seen, just beautiful


text:
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Rochester, Minn.
I. To determine the maximum tolerated doses (MTD) of LBH589 (panobinostat) and RAD001 (everolimus) when used in combination in patients with myeloma or lymphoma. (Phase I) II. To evaluate the therapeutic activity of the combination of LBH589 with RAD001 in patients with relapsed or refractory lymphoma. (Arm A, phase II) III. To evaluate the therapeutic activity of the combination of LBH589 with RAD001 in patients with relapsed or refractory multiple myeloma. (Arm B, phase II)
I. To describe the toxicities associated with the combination of LBH589 with RAD001. (Phase I) II. To further describe the toxicities associated with the combination of LBH589 with RAD001 in each arm independently. (Phase II) III. To evaluate overall survival, progression-free survival, and duration of response in each arm independently. (Phase II)
I. To evaluate the pharmacokinetic interaction of LBH589 and RAD001. II. To assess the correlation between clinical (toxicity and/or tumor response or activity) effects with the pharmacologic (pharmacokinetic/pharmacodynamic) parameters, and/or biologic (correlative laboratory) results.
OUTLINE: This is a phase I, dose-escalation study of panobinostat and everolimus followed by a phase II study. (dose-escalation closed to accrual as of April 6, 2011)
Patients receive panobinostat orally (PO) once daily (QD) or on days 1, 3, 5, 15, 17, and 19 and everolimus PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 2 years.
Inclusion Criteria:
- Relapsed or refractory multiple myeloma requiring therapy, who have failed, unable to tolerate, or refused other available active therapies
- Biopsy-proven relapsed or refractory non-Hodgkin lymphoma or Hodgkin disease requiring treatment, who have failed, unable to tolerate, or refused other available active therapies; patients should not have other treatment options considered curative; (NOTE: for patients with lymphoma, a re-biopsy is necessary unless the patient has had a previous biopsy < 6 months prior to treatment on this protocol if there has been no intervening treatment; patients with biopsy-proven central nervous system [CNS] lymphoma at any time are not required to have a re-biopsy to be eligible for this study)
- Multiple myeloma:
- Serum monoclonal protein >= 1.0 g/dL
- >= 200 mg of monoclonal protein in the urine on 24 hour electrophoresis
- Serum immunoglobulin free light chain >= 10 mg/dL AND abnormal serum immunoglobulin kappa to lambda free light chain ratio
- Monoclonal bone marrow plasmacytosis >= 30% (evaluable disease) at time of registration
- Lymphoma:
- Measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) or the CT portion of the positron emission tomography (PET)/CT; must have at least one lesion that has a single diameter of >= 2 cm or tumor cells in the blood >= 5 x 10^9/L; skin lesions can be used if the area is >= 2 cm in at least one diameter and photographed with a ruler
- The following disease types are eligible:
- Transformed lymphomas
- Diffuse large B cell lymphoma
- Mantle cell lymphoma
- Follicular lymphoma grade III
- Precursor B lymphoblastic leukemia/lymphoma
- Mediastinal (thymic) large B-cell lymphoma
- Burkitt lymphoma/leukemia
- Precursor T-lymphoblastic leukemia/lymphoma
- Primary cutaneous anaplastic large cell lymphoma
- Anaplastic large cell lymphoma - primary systemic type
- Small lymphocytic lymphoma/chronic lymphocytic leukemia
- Follicular lymphoma, grades 1, 2
- Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
- Nodal marginal zone B-cell lymphoma
- Splenic marginal zone B-cell lymphoma
- Peripheral T cell lymphoma, unspecified.
- Anaplastic large cell lymphoma (T and null cell type)
- Lymphoplasmacytic lymphoma (Waldenstrom Macroglobulinemia)
- CNS lymphoma
- Post transplant lymphoproliferative disorders
- Mycosis fungoides/Sezary syndrome
- Hodgkin Disease
- Primary effusion lymphoma
- Blastic natural killer (NK)-cell lymphoma
- Adult T-cell leukemia/lymphoma
- Extranodal NK/T-cell lymphoma, nasal type
- Enteropathy-type T-cell lymphoma
- Hepatosplenic T-cell lymphoma
- Subcutaneous panniculitis-like T-cell lymphoma
- Angioimmunoblastic T-cell lymphoma
- Anaplastic large cell lymphoma - primary cutaneous type
- For lymphoplasmacytic lymphoma patients without measurable lymphadenopathy, measurable disease can be defined by both of the following criteria:
- Bone marrow lymphoplasmacytosis with > 10% lymphoplasmacytic cells or aggregates, sheets, lymphocytes, plasma cells, or lymphoplasmacytic cells on bone marrow biopsy and
- Quantitative immunoglobulin (Ig)M monoclonal protein > 1,000 mg/dL
- Absolute neutrophil count (ANC) >= 1000/uL
- Hemoglobin (Hgb) >= 9 g/dl
- Platelets (PLT) >= 75,000/uL
- Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN the direct bilirubin must be normal
- Aspartate aminotransferase (AST) =< 3 x ULN
- Creatinine =< 2.5 x ULN
- Serum potassium, magnesium and phosphorus >= lower limit of normal (LLN) and =< 1.2 x ULN
- Ionized calcium >= LLN
- Thyroid-stimulating hormone (TSH) =< 1.5 x ULN; patients are permitted to receive thyroid hormone supplements to treat underlying hypothyroidism
- Ability to understand and the willingness to sign a written informed consent document
- Willingness to return to Mayo Clinic or National Cancer Institute, National Institutes of Health (NIH) - Medical Oncology Branch, Center for Cancer Research (CCR)
- Life expectancy >= 12 weeks
- Willing to provide blood samples for research studies as required by the protocol
- Negative pregnancy test done =< 7 days prior to registration, for women of childbearing potential only
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2
Exclusion Criteria:
- Candidate for known standard therapy for the patient's disease that is potentially curative
- Uncontrolled infection
- Therapy with myelosuppressive chemotherapy or biologic therapy < 3 weeks unless the patient has recovered from the nadir of the previous treatment to a level that meets the inclusion eligibility criteria of this protocol; NOTE: patients who have received prior RAD001 therapy will be allowed but must meet above requirements
- Receiving corticosteroids > 20 mg of prednisone per day (or equivalent); NOTE: patients may be receiving stable (not increased within the last month) chronic doses of corticosteroids with a maximum dose of 20 mg of prednisone per day if they are being given for disorders other than lymphoma (with the exception of CNS lymphoma, which steroids are permitted at the lowest possible dose necessary and should not be escalated during treatment) such as rheumatoid arthritis, polymyalgia rheumatica or adrenal insufficiency, or asthma
- Persistent toxicities >= grade 2 from prior chemotherapy or biological therapy regardless of interval since last treatment
- Impaired cardiac function or clinically significant cardiac diseases, including any one of the following:
- Patients with congenital long QT syndrome
- History or presence of sustained ventricular tachyarrhythmia; (patients with a history of atrial arrhythmia are eligible but should be discussed with the Sponsor prior to enrollment)
- Any history of ventricular fibrillation or torsade de pointes
- Bradycardia defined as heart rate (HR) < 50 beats per minute (bpm;) patients with pacemakers are eligible if HR >= 50 bpm
- Screening electrocardiogram (ECG) with a QTcFredericia (QTcF) > 450 msec
- Right bundle branch block + left anterior hemiblock (bifascicular block)
- Patients with myocardial infarction or unstable angina =< 6 months prior to starting study drug
- Other clinically significant heart disease (e.g., congestive heart failure [CHF] New York [NY] Heart Association class III or IV, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen)
- Any of the following:
- Pregnant women or women of reproductive ability who are unwilling to use effective contraception
- Nursing women
- Men who are unwilling to use a condom (even if they have undergone a prior vasectomy) while having intercourse with any woman, while taking the drug and for 4 weeks after stopping treatment
- Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration [FDA]-approved indication and in the context of a research investigation); NOTE: patients may undergo palliative concurrent radiation of myeloma lesions for pain control or impending fracture, provided the lesion(s) by themselves do not constitute progression
- Known positivity for human immunodeficiency virus (HIV) or hepatitis C with uncontrolled disease; baseline testing for HIV is not required; Note: a detailed assessment of Hepatitis B/C medical history and risk factors must be done at screening for all patients; hepatitis b virus (HBV) deoxyribonucleic acid (DNA) and hepatitis C virus (HCV) ribonucleic acid (RNA) polymerase chain reaction (PCR) testing are required at screening for all patients with a positive medical history based on risk factors and/or confirmation of prior HBV infection
- Active other malignancy requiring treatment that would interfere with the assessments of response of the lymphoma or myeloma to protocol treatment
- Inability to swallow or impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of the drugs (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection) that would preclude use of oral medications
- Thrombotic or embolic events such as a cerebrovascular accident including transient ischemic attacks within the past 6 months
- Any severe and/or uncontrolled medical conditions or other conditions that, in the treating physician's opinion, could adversely impact their ability to participate in the study; NOTE: patients on chronic oxygen therapy, those with liver disease such as cirrhosis, chronic hepatitis or chronic persistent hepatitis, or uncontrolled infections will be excluded
- Known hypersensitivity to RAD001 (everolimus) or other rapamycins (sirolimus, temsirolimus)
- Receiving any medications or substances that are strong or moderate inhibitors of CYP3A4; receiving any medications or substances that are inducers of CYP3A4
- Using medications that have a relative risk of prolonging the QT interval or inducing torsade de pointes if treatment cannot be discontinued or switched to a different medication prior to starting study drug
- Active bleeding tendency; NOTE: patients on therapeutic anticoagulation should be monitored carefully to maintain therapeutic level of anticoagulation to avoid increased risk of bleeding due to concurrent drug induced thrombocytopenia; it is suggested that patients who require anticoagulation therapy while on therapy use low molecular weight heparin (LMWH)
- Major surgery =< 4 weeks prior to registration or have not recovered from side effects of such therapy
Cancer-Related Clinical Trial Request Form
Rochester: Clinical Trials Referral Office 855-776-0015
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Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
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About Us
Country Woman is a bimonthly magazine with subscribers across the United States and Canada. Published since 1970 for women who live in or long for the country, this magazine celebrates their diversity, strength and spirit.
Positive, upbeat, entertaining and informative, Country Woman reflects the many roles and interests of its readers through profiles of women and their lifestyle.
Each issue features a large food section filled with mouth-watering, down-home recipes for today's cooks, including winning recipes for the issue's contest. There are also ideas for easy and frugal country decorating, casual entertaining, fun and appealing crafts, garden tips, lifestyle stories, health advice, puzzles, nostalgia and more.
Our readers say that every issue of Country Woman feels like a chat with a good friend over a cup of coffee. Subscribe today or give a gift of Country Woman.
Editor Lori Lau Grzybowski
"Hearing what's important to our readers—whether I'm talking with them or reading what they've written—is my favorite thing about working on Country Woman," shares Lori. "Their creativity and insights constantly amaze and inspire me."
She enjoys the many duties that keep her busy—from reading manuscripts to selecting stories and photography or editing stories and judging contest entries. "But I have to admit," Lori says with a grin, "the food-tastings are fun, too!"
Lori and her husband have an adult daughter, two teen-aged sons and one new grandson. They spend much of their time cheering at events as well as participating in various church activities. "In my spare time, I love to read," says Lori. She also plays a mean game of Boggle and recently got hooked on Sudoku (thanks, in part, to Country Woman)!
Senior Editor Sharon Selz
What has Senior Editor Sharon Selz enjoyed the most in her years with Country Woman? Interviewing fascinating rural women from across the country and sharing their stories. "How else could I have obtained such a great insight into the life of an Amish woman and expert quilter or the how-to's of raising Longhorn cattle?" asks Sharon.
"I'll always remember the very first story I worked on," says Sharon. "It featured a Wyoming ranch woman who took guests on five-day trail rides using covered wagons she and her family built." Having been raised in the country surrounded by rural women, Sharon is thrilled to show the world how special they are. "Some of our readers don't notice their own uniqueness or the value of what they contribute to their families and communities and to society," adds Sharon.
Contributing Editor Ann Kaiser
Who would think you could make someone into a camel herder…corn detasseler…honey harvester? But these are just a few of the exciting, unique and challenging jobs Contributing Editor Ann Kaiser has done for Country Woman.
The "Editor in the Country" series has taken Ann to all 50 states and most of the Canadian provinces. Ann started accepting invitations from readers to "come work a day with me" in 1976. Her hard-working country hostesses have taught her a thing or two—and put her to the test in many memorable ways.
Photo credit: Christiaan Blok


text: Joe Cecil I absolutely hate hes gone. I am a die hard bears guy and they could have at least signed him to a 1 year deal and kept him for certain schemes. Its a shame to see a guy play 13 seasons with one team and then get the boot because hes aging a bit and not 100% healthy. Even though hes not 100% healthy they could have had him for special plays and he would have for sure brought the vet leadership like he always has. At least he retired a Bear and Brian Chicago and Illinois will miss ya! Posted May 22, 2013 at 8:39 pm | Permalink


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Donors and Partners provide challenge LEAD Scholarship matching funds
Thanks to a generous donor, TouchPoints recently received a challenge matching gift of up to $2,000, designated to provide scholarships for LEAD, our leadership training program. The donor will match every dollar donated to TouchPoints Scholarship Fund! Please consider a donation to help us maximize this amazing opportunity, to extend training to women who would otherwise be unable to afford attending. Would you join us in strengthening women in ministry and leadership?


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I attended a networking event for IBM Other Than Traditional Office employees (OTTO, for short) – people who work from home, client sites, mobility centers, and other places. It was held in Second Life Enterprise to take advantage of the Center for Advanced Learning's speed-networking tools: a system for assigning conversational groups, sound-isolated tables so that you could talk without interfering with other tables, and a screen for information.
Here's what I learned from the eight people I got to talk to:
All the questions in the post-networking group chat were about the platform. I've been to a number of IBM events in SecondLife, and I think it can be a great way to connect. Looking forward to seeing other groups take advantage of this!


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Beijing Honey Homestay Apartment
Official Contact Details - Beijing Honey Homestay
Comfortable 3 bedroom flat with easy transport to the city center and airport.
- Price from 150 CNY / Day
- Capacity up to 6 people
- 3 bedrooms & 1 bathroom
(click on a photo to view it)
Last updated: 02/17/2006
This is your property ?
Mike and Aria (husband and wife) have lived out of China for several years and experienced homestays for many times. Now they are running their own homestay in Beijing.
Honey Homestay is ten minutes' Subway away from the city centre and fifteen minutes' drive from the Beijing International Airport. It's surrounded by Olympic Sports Centre, natural park, Golf Course and shopping mall. It is also easy to reach the great scenery spots such as the Summer Palace, the Great Wall, the Ming Tombs, etc. without going through the crowded city center.
Honey Homestay is a safe, clean and cosy apartment in the biggest living district in Beijing. Here you have more chances to know about the Chinese culture. All the facilities such as TV, refridge, shower, washing room with washing machine, kitchen with self-catering stuffs, mobile phone (exclusive the prepaid card), are of good quality and free to use. You can relax yourself in the big sitting room just like staying at home. The most important point is that You can learn Chinese while you stay since Aria is a qualified teacher with fluent English.
Prices & deals
- Lowest Daily Price:
- Highest Daily Price:
- Lowest Weekly Price:
- Highest Weekly Price:
- Cleaning fee:
- Charging Method:
- Payment Types:
- Cash
- Credit Card
- Cheque
- Travellers cheque
- Paypal
- Wire Transfer
Location & area
between the Beijing city center and the Beijing International Airport. In the northeast of Beijing city.
- Address:
- 5 Wangjing Residential Area, Chaoyang District, 100102, Beijing, China
- Accommodation located in:
- city, near golf course, near substation, suburb!
Amenities & services
Chinese language training course
# of Units: 1... and each unit includes:
- Bedrooms: 3
- Bathrooms: 1
- Single beds: 4
- Double beds: 2
- Baby cots: 1
- Single sofa beds: 1
- Double sofa beds: 0
- Towels:
- Bath:
- Hair Drier:
- Shower:
- DVD Player:
- Fax:
- Washing Machine:
- Work Desk:
- Bed Sheets:
- Bikes:
- Cable/Satelite TV:
- Internet Broadband:
- Internet Dial Up:
- Ironing Board:
- Library:
- Stereo/Radio System:
- Telephone:
- 24h Concierge:
- Tours & Excursions:
- Butler Service:
- House Chef:
- Local Guides:
- Local Transportation:
- Microwave:
- Oven:
- American Kitchen:
- Fridge & Freezer:
- Crockery & Utensils:
- Dish Washer:
Living room
- Fireplace:
- Sofa Bed:
- Table & Chairs:
- Tennis Court:
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- Pets Welcome:
- Private Beach:
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- Shared Bathroom:
- Spa / Jacuzzi:
- Lift / Elevator:
- Swimming Pool:
- Disabled Facilities:
- DVD/Music Collection:
- Air Conditioning:
- Ensuite Bathroom:
- Balcony:
- Safe:
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- Central Heating:
- City View:
- Daily Cleaning:
Review - Beijing Honey Homestay
Beijing Honey Homestay - Contact the owner
Important Notice : Avoiding Fraud
It's rare, but some helpful hints to watch out for with regards to fraud:
- It is important to NEVER wire funds or use/employ other fund transfer mechanisms such as western union: Always use a credit card to protect yourself against fraud. If owners pressure you into providing a deposit or refuse to accept credit cards, there is a high probability that this is a scam.
- If at all suspicious of fraud, ask to see their website, or any other literature they can provide or send to you. Ask them for contact details for guests who have previously stayed on their property insisting on telephone numbers. Be suspicious of emails that originate from free email services (yahoo, hotmail, gmail, etc)
- Research the property thoroughly on the internet to see if there is any history or mention of scams associated with the property.


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