text:
|This strain is now distributed by the Mutant Mouse Regional Resource Center. Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for ordering information and strain details on C3B6-Tg(APP695)3Dbo/Mmjax
MMRRC Stock Number 034828.
As a designated MMRRC center, The Jackson Laboratory will continue to distribute these mice at the same high health and
quality standards but ordering is exclusively provided through the MMRRC.
|These transgenic mice (formerly JAX Stock No. 003375) express the human amyloid precursor protein bearing the Swedish (K670N/M671L) mutation and develop amyloid deposits in brain tissue by 18-20 months of age. These mice provide a useful model for studying the underlying mechanism of amyloid deposition, a process implicated in Alzheimer's disease (AD).
Former Names C3B6-Tg(APP695)3Dbo/J (Changed: 10-AUG-11 ) C57BL/6-TgN(Prn-APP695)3Dbo (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Dr. David R Borchelt, University of Florida
These transgenic mice express the human amyloid precursor protein bearing the Swedish (K670N/M671L) mutation and develop amyloid deposits in brain tissue by 18-20 months of age. These mice provide a useful model for studying the underlying mechanism of amyloid deposition, a process implicated in Alzheimer's disease (AD).
Mouse pronuclei (B6C3H) were injected with a transgenic construct containing a cDNA encoding a chimeric amyloid beta (A4) precursor protein (APP695) regulated by the mouse prion promoter. The chimeric APP695 molecule was created by replacing sequences encoding the Abeta domain of the murine sequence with the cognate sequences of the human gene and mutations K595N and M596L (APP695 isoform numbering).
Alzheimer's Disease Models
005987 129-Achetm1Loc/J 006409 129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax 008077 129S1/Sv-Bchetm1Loc/J 016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 014556 129S6/SvEv-Apoetm4Mae/J 006555 A.129(B6)-Tg(APPSw)40Btla/Mmjax 005708 B6.129-Apbb1tm1Quhu/J 004714 B6.129-Bace1tm1Pcw/J 004098 B6.129-Klc1tm1Gsn/J 004193 B6.129-Psen1tm1Mpm/J 003615 B6.129-Psen1tm1Shn/J 005300 B6.129-Tg(APPSw)40Btla/Mmjax 005617 B6.129P-Psen2tm1Bdes/J 002609 B6.129P2-Nos2tm1Lau/J 007685 B6.129P2-Psen1tm1Vln/J 007999 B6.129P2-Sorl1Gt(Ex255)Byg/J 008087 B6.129S1-Bchetm1Loc/J 002509 B6.129S2-Plautm1Mlg/J 005301 B6.129S2-Tg(APP)8.9Btla/J 004163 B6.129S4-Cdk5r1tm1Lht/J 010959 B6.129S4-Grk5tm1Rjl/J 010960 B6.129S4-Grk5tm2Rjl/J 002213 B6.129S4-Ngfrtm1Jae/J 006406 B6.129S4-Tg(APPSwLon)96Btla/Mmjax 006469 B6.129S4-Tg(PSEN1H163R)G9Btla/J 012564 B6.129S5-Dhcr24tm1Lex/SbpaJ 004142 B6.129S7-Aplp2tm1Dbo/J 004133 B6.129S7-Apptm1Dbo/J 007251 B6.129X1-Mapttm1Hnd/J 013040 B6.Cg-Apoetm1Unc Ins2Akita/J 005642 B6.Cg-Clutm1Jakh/J 005491 B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 009126 B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax 005866 B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax 008730 B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 005864 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 007575 B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J 016197 B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J 005855 B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J 007004 B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ 004996 B6.Cg-Tg(DBH-Gal)1923Stei/J 007673 B6.Cg-Tg(Gad1-EGFP)3Gfng/J 004662 B6.Cg-Tg(PDGFB-APP)5Lms/J 006293 B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax 006006 B6.Cg-Tg(Prnp-APP)A-2Dbo/J 008596 B6.Cg-Tg(Prnp-Abca1)EHol/J 006005 B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax 007180 B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J 007182 B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J 005999 B6.Cg-Tg(SBE/TK-luc)7Twc/J 012597 B6.Cg-Tg(Thy1-COL25A1)861Yfu/J 007051 B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax 007052 B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax 007049 B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax 009337 B6.FVB-Tg(Prnp-RTN3)2Yanr/J 006394 B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J 008364 B6;129-Chattm1(cre/ERT)Nat/J 008476 B6;129-Ncstntm1Sud/J 004807 B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax 007605 B6;129P-Psen1tm1Vln/J 005618 B6;129P2-Bace2tm1Bdes/J 008333 B6;129P2-Dldtm1Ptl/J 002596 B6;129P2-Nos2tm1Lau/J 003822 B6;129S-Psen1tm1Shn/J 012639 B6;129S4-Mapttm3(HDAC2)Jae/J 012869 B6;129S6-Apbb2tm1Her/J 006410 B6;129S6-Chattm2(cre)Lowl/J 005993 B6;129S6-Pcsk9tm1Jdh/J 008636 B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J 007002 B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax 008169 B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J 000231 B6;C3Fe a/a-Csf1op/J 008850 B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ 003378 B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J 004462 B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 003741 B6D2-Tg(Prnp-MAPT)43Vle/J 016556 B6N.129-Ptpn5tm1Pjlo/J 018957 B6N.129S6(B6)-Chattm2(cre)Lowl/J 024841 B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J 006554 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 012621 C.129S(B6)-Chrna3tm1.1Hwrt/J 002328 C.129S2-Plautm1Mlg/J 005087 C57BL/6-Tg(Camk2a-IDE)1Selk/J 005086 C57BL/6-Tg(Camk2a-MME)3Selk/J 008833 C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J 007027 C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax 010800 C57BL/6-Tg(Thy1-PTGS2)300Kand/J 010703 C57BL/6-Tg(Thy1-PTGS2)303Kand/J 005706 C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J 006618 C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J 007677 CB6-Tg(Gad1-EGFP)G42Zjh/J 007072 CByJ.129P2(B6)-Nos2tm1Lau/J 006472 D2.129(B6)-Tg(APPSw)40Btla/Mmjax 007067 D2.129P2(B6)-Apoetm1Unc/J 013719 D2.Cg-Apoetm1Unc Ins2Akita/J 003718 FVB-Tg(GadGFP)45704Swn/J 013732 FVB-Tg(NPEPPS)1Skar/J 013156 FVB-Tg(tetO-CDK5R1*)1Vln/J 015815 FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ 002329 FVB.129S2-Plautm1Mlg/J 003753 FVB/N-Tg(Eno2CDK5R1)1Jdm/J 006143 FVB/N-Tg(Thy1-cre)1Vln/J 008051 NOD.129P2(B6)-Ctsbtm1Jde/RclJ 008390 STOCK Apptm1Sud/J 012640 STOCK Hdac2tm1.2Rdp/J 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 004779 STOCK Mapttm1(EGFP)Klt/J 014092 STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J 014544 STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/JView Alzheimer's Disease Models (109 strains)Strains carrying Tg(APP695)3Dbo allele
005866 B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax 003378 B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/JView Strains carrying Tg(APP695)3Dbo (2 strains)Strains carrying other alleles of APP695
008730 B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 007180 B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J 007182 B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J 007051 B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax 007052 B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax 008636 B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J 007002 B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax 006554 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/MmjaxView Strains carrying other alleles of APP695 (8 strains)Strains carrying other alleles of Prn
005864 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 004462 B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 003627 B6C3-Tg(HD82Gln)81Gschi/JView Strains carrying other alleles of Prn (3 strains)
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
View Related Disease (OMIM) TermsRelated Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.Alzheimer Disease 4
Alzheimer Disease; AD
View Mammalian Phenotype TermsMammalian Phenotype Terms provided by MGIassigned by genotype
Tg(APP695)3Dbo/0involves: C3H/HeJ * C57BL/6J
- nervous system phenotype
- *normal* nervous system phenotype
- no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0 (MGI Ref ID J:43788)
- homeostasis/metabolism phenotype
- amyloid beta deposits
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.
- nervous system phenotype
- amyloid beta deposits
- in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations (MGI Ref ID J:109847)
- mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice (MGI Ref ID J:109847)
- old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals (MGI Ref ID J:109847)
- behavior/neurological phenotype
- abnormal motor capabilities/coordination/movement
- at 24 months, males display a mild deterioration of sensorimotor abilities (MGI Ref ID J:109847)
- abnormal locomotor behavior
- in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task (MGI Ref ID J:109847)
- increased startle reflex
- mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type (MGI Ref ID J:109847)
- homeostasis/metabolism phenotype
- amyloid beta deposits
- in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations (MGI Ref ID J:109847)
- mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice (MGI Ref ID J:109847)
- old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals (MGI Ref ID J:109847)View Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Tg(APP695)3Dbo related
Neurobiology Research
Alzheimer's Disease
strains expressing mutant APP
Neurobiology Research
Alzheimer's Disease
|Allele Symbol
|Allele Name
|transgene insertion 3, David R Borchelt
|Allele Type
|Transgenic (Inserted expressed sequence)
|Common Name(s)
|APP695; APP695swe; APPswe; Mo/HuAPPswe; line C3-3;
|Mutation Made By
|Dr. David Borchelt, University of Florida
|Strain of Origin
|(C57BL/6J x C3H/HeJ)F2
|Expressed Gene
|APP695, amyloid beta (A4) precursor protein (chimeric), mouse/human chimera
|Prn, prion protein gene complex, mouse, laboratory
|General Note
Three transgenic lines were generated and designated by the authors lines Q2-2, E1-2 (Tg(Prnp-App/APPswe)E1-2Dbo) and C3-3.
This line was generated from founder number C3-3.
Transgenic mice develop amyloid deposits in brain tissue by 18-20 months of age.
Transgenic mice that are also transgenic for Tg(PSEN1)5Dboexpress both human presenilin 1 (A246E variant) and a chimeric amyloid precursor protein (APPSwe) under direction of the mouse prion protein promoter. Elevated levels of the AB1-42(43) peptide are detected in brain homogenates. By nine months of age, histological examination of brain tissue from these mice reveals numerous amyloid deposits resembling those observed in the brains of patients with Alzheimer's disease (AD). The number of amyloid deposits increases dramatically between the ages of 10 and 12 months.
|Molecular Note
|The transgene is composed of a cDNA encoding a chimeric APP protein regulated by the mouse prion promoter. The chimeric APP molecule was created by replacing sequences encoding the Abeta domain of a 695 amino acid isoform of the murine sequence with the cognate sequences of the human gene (mutations K595N, M596L). The human mutations are found in familial Alzheimer's disease. Transgene expression was observed in the brain and heart by Western blot analysis using a monoclonal antibody recognizing the human Abeta region. [MGI Ref ID J:80782]
Genotyping ProtocolsGeneric Tg(APP), Standard PCR
Helpful LinksGenotyping resources and troubleshooting
Borchelt DR; Thinakaran G; Eckman CB; Lee MK; Davenport F; Ratovitsky T; Prada CM; Kim G; Seekins S; Yager D; Slunt HH; Wang R; Seeger M; Levey AI; Gandy SE; Copeland NG; Jenkins NA; Price DL; Younkin SG; Sisodia SS. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17(5):1005-13. [PubMed: 8938131] [MGI Ref ID J:80882]
Borchelt DR; Davis J; Fischer M; Lee MK; Slunt HH; Ratovitsky T; Regard J; Copeland NG; Jenkins NA; Sisodia SS; Price DL. 1996. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13(6):159-63. [PubMed: 9117892] [MGI Ref ID J:80782]
Borchelt DR; Ratovitski T; van Lare J; Lee MK; Gonzales V; Jenkins NA; Copeland NG; Price DL; Sisodia SS. 1997. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19(4):939-45. [PubMed: 9354339] [MGI Ref ID J:43788]Tg(APP695)3Dbo related
Bailey AR; Hou H; Obregon DF; Tian J; Zhu Y; Zou Q; Nikolic WV; Bengtson M; Mori T; Murphy T; Tan J. 2012. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: implications for autism. FASEB J 26(3):1040-51. [PubMed: 22085641] [MGI Ref ID J:182808]
Boissonneault V; Plante I; Rivest S; Provost P. 2009. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 284(4):1971-81. [PubMed: 18986979] [MGI Ref ID J:146980]
Borchelt DR; Davis J; Fischer M; Lee MK; Slunt HH; Ratovitsky T; Regard J; Copeland NG; Jenkins NA; Sisodia SS; Price DL. 1996. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13(6):159-63. [PubMed: 9117892] [MGI Ref ID J:80782]
Borchelt DR; Ratovitski T; van Lare J; Lee MK; Gonzales V; Jenkins NA; Copeland NG; Price DL; Sisodia SS. 1997. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19(4):939-45. [PubMed: 9354339] [MGI Ref ID J:43788]
Cai D; Zhong M; Wang R; Netzer WJ; Shields D; Zheng H; Sisodia SS; Foster DA; Gorelick FS; Xu H; Greengard P. 2006. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A 103(6):1936-40. [PubMed: 16449385] [MGI Ref ID J:106075]
Cai Y; Xue ZQ; Zhang XM; Li MB; Wang H; Luo XG; Cai H; Yan XX. 2012. An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation. Neuroscience 215:160-73. [PubMed: 22542680] [MGI Ref ID J:192436]
Dodson SE; Andersen OM; Karmali V; Fritz JJ; Cheng D; Peng J; Levey AI; Willnow TE; Lah JJ. 2008. Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci 28(48):12877-86. [PubMed: 19036982] [MGI Ref ID J:142501]
Dolev I; Fogel H; Milshtein H; Berdichevsky Y; Lipstein N; Brose N; Gazit N; Slutsky I. 2013. Spike bursts increase amyloid-beta 40/42 ratio by inducing a presenilin-1 conformational change. Nat Neurosci 16(5):587-95. [PubMed: 23563578] [MGI Ref ID J:197603]
El-Amouri SS; Zhu H; Yu J; Marr R; Verma IM; Kindy MS. 2008. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol 172(5):1342-54. [PubMed: 18403590] [MGI Ref ID J:134308]
Filali M; Lalonde R. 2009. Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Res 1292:93-9. [PubMed: 19643098] [MGI Ref ID J:157207]
Filali M; Lalonde R; Rivest S. 2008. Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav 8(2):143-8. [PubMed: 19077180] [MGI Ref ID J:142183]
Filali M; Lalonde R; Rivest S. 2011. Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 60(6):930-6. [PubMed: 21281652] [MGI Ref ID J:178504]
Garcia-Alloza M; Dodwell SA; Meyer-Luehmann M; Hyman BT; Bacskai BJ. 2006. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 65(11):1082-9. [PubMed: 17086105] [MGI Ref ID J:120918]
Gureviciene I; Ikonen S; Gurevicius K; Sarkaki A; van Groen T; Pussinen R; Ylinen A; Tanila H. 2004. Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice. Neurobiol Dis 15(2):188-95. [PubMed: 15006688] [MGI Ref ID J:128772]
Helft J; Manicassamy B; Guermonprez P; Hashimoto D; Silvin A; Agudo J; Brown BD; Schmolke M; Miller JC; Leboeuf M; Murphy KM; Garcia-Sastre A; Merad M. 2012. Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest 122(11):4037-47. [PubMed: 23041628] [MGI Ref ID J:193561]
Huang HJ; Liang KC; Ke HC; Chang YY; Hsieh-Li HM. 2011. Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice. Brain Res 1371:150-60. [PubMed: 21114967] [MGI Ref ID J:170247]
Iivonen H; Nurminen L; Harri M; Tanila H; Puolivali J. 2003. Hypothermia in mice tested in Morris water maze. Behav Brain Res 141(2):207-13. [PubMed: 12742257] [MGI Ref ID J:130974]
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR. 2004. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13(2):159-70. [PubMed: 14645205] [MGI Ref ID J:87691]
Jankowsky JL; Melnikova T; Fadale DJ; Xu GM; Slunt HH; Gonzales V; Younkin LH; Younkin SG; Borchelt DR; Savonenko AV. 2005. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci 25(21):5217-24. [PubMed: 15917461] [MGI Ref ID J:98541]
Jankowsky JL; Slunt HH; Gonzales V; Jenkins NA; Copeland NG; Borchelt DR. 2004. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging 25(7):885-92. [PubMed: 15212842] [MGI Ref ID J:102351]
Kalesnykas G; Roschier U; Puolivali J; Wang J; Miettinen R. 2005. The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice. Eur J Neurosci 21(5):1437-42. [PubMed: 15813954] [MGI Ref ID J:101077]
Kanekiyo T; Cirrito JR; Liu CC; Shinohara M; Li J; Schuler DR; Shinohara M; Holtzman DM; Bu G. 2013. Neuronal clearance of amyloid-beta by endocytic receptor LRP1. J Neurosci 33(49):19276-83. [PubMed: 24305823] [MGI Ref ID J:204149]
Kanekiyo T; Liu CC; Shinohara M; Li J; Bu G. 2012. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta. J Neurosci 32(46):16458-65. [PubMed: 23152628] [MGI Ref ID J:192453]
Ke HC; Huang HJ; Liang KC; Hsieh-Li HM. 2011. Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise. Brain Res 1403:1-11. [PubMed: 21689809] [MGI Ref ID J:174067]
Khan UA; Liu L; Provenzano FA; Berman DE; Profaci CP; Sloan R; Mayeux R; Duff KE; Small SA. 2014. Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease. Nat Neurosci 17(2):304-11. [PubMed: 24362760] [MGI Ref ID J:208008]
Laird FM; Cai H; Savonenko AV; Farah MH; He K; Melnikova T; Wen H; Chiang HC; Xu G; Koliatsos VE; Borchelt DR; Price DL; Lee HK; Wong PC. 2005. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25(50):11693-709. [PubMed: 16354928] [MGI Ref ID J:123534]
Lazarov O; Morfini GA; Pigino G; Gadadhar A; Chen X; Robinson J; Ho H; Brady ST; Sisodia SS. 2007. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci 27(26):7011-20. [PubMed: 17596450] [MGI Ref ID J:122975]
Lee GD; Aruna JH; Barrett PM; Lei DL; Ingram DK; Mouton PR. 2005. Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res Bull 65(4):317-22. [PubMed: 15811597] [MGI Ref ID J:135436]
Lesuisse C; Xu G; Anderson J; Wong M; Jankowsky J; Holtz G; Gonzalez V; Wong PC; Price DL; Tang F; Wagner S; Borchelt DR. 2001. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Hum Mol Genet 10(22):2525-37. [PubMed: 11709540] [MGI Ref ID J:72987]
Li G; Zou L; Jack CR Jr; Yang Y; Yang ES. 2007. Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein. Neurobiol Aging 28(6):877-82. [PubMed: 16806588] [MGI Ref ID J:121939]
Li L; Zhang X; Yang D; Luo G; Chen S; Le W. 2009. Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging 30(7):1091-8. [PubMed: 18063223] [MGI Ref ID J:152965]
Liang C; Zhu H; Xu Y; Huang L; Ma C; Deng W; Liu Y; Qin C. 2012. MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2. Brain Res 1455:103-13. [PubMed: 22510281] [MGI Ref ID J:186457]
Liu L; Ikonen S; Heikkinen T; Heikkila M; Puolivali J; van Groen T; Tanila H. 2002. Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice. Behav Brain Res 134(1-2):433-45. [PubMed: 12191831] [MGI Ref ID J:129807]
Liu L; Tapiola T; Herukka SK; Heikkila M; Tanila H. 2003. Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice. Neuroreport 14(1):163-6. [PubMed: 12544850] [MGI Ref ID J:89843]
Liu Y; Yoo MJ; Savonenko A; Stirling W; Price DL; Borchelt DR; Mamounas L; Lyons WE; Blue ME; Lee MK. 2008. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci 28(51):13805-14. [PubMed: 19091971] [MGI Ref ID J:143521]
Lopez JR; Lyckman A; Oddo S; Laferla FM; Querfurth HW; Shtifman A. 2008. Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. J Neurochem 105(1):262-71. [PubMed: 18021291] [MGI Ref ID J:141555]
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Gear Question
Im a shoe size 10, should i size down or...
shawn chang
Member since
Im a shoe size 10, should i size down or stay true to size? thanks
Member since
I would stay with you normal size of 10. They are pretty soft, so if you usually pack out a boot maybe go ½ size down but not a full size, again, they're fairly true and don't think you'll need to do that even.
View More Details on Rome Libertine Snowboard Boot - Men's

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Monday, July 26, 2010
A TV shout-out to a debonair palace for independent women
postcard from Old New York
With Mad Men making its return last night on AMC, myself and many other bloggers (like the fabulous Natasha Vargas-Cooper and the folks over at the City Room) are scouring the episodes for fun New York City history references. One of my favorite buildings in the city made an appearance (or at least a notable mention) when, after a blind date, Don Draper drops his actress lady friend off at her home at the Barbizon Hotel for Women at 140 E. 63rd Street.
The Barbizon was a high-end complex for actresses and models, "a combined charm school and dormitory," "the city's elite dollhouse" according to Vanity Fair, offering single woman a luxurious address and a home base to pursue career and network. Some of its inhabitants, naturally, would go on to become major stars -- Grace Kelly, Lauren Bacall, Cloris Leachman, Liza Minelli. Little Edie, of 'Grey Gardens' fame, lived here from 1947 to 1952 while trying to break into show business.
I personally love the dark grown, arch-heavy exterior, which the AIA calls a "romantic, neo-Gothic tawny brick charmer." The building opened to men in 1981 and, as the Barbizon 63, is still a rather swanky address.
The Barbizon, however, was not known for sumptuous living back in the day. Apparently, a lady was just supposed to be grateful to be admitted here. The rooms were "not luxurious," according to a biography on Kelly, "and a new girl's first impression might have been that her austere quarters resembled a convent cell or a house of correction." Kelly lived here as a teenager in 1947, quietly reading or having tea in the Barbizon's dining area.
The building was designed in 1927 by the curiously named design firm of Murgatroyd & Ogden, who specialized in brick hotels and apartment complexes with quirky flair. Two years later, their Hotel Governor Clinton opened across the street from Pennsylvania Station.
(New Yorker ad from 1966 courtesy Ephemeral New York)
6 comments:
I don't have a copy handy, but the main character in Plath's The Bell Jar lives at one of these hotels at some point. Could the one in the book be inspired by the one you are writing about?ReplyDelete
Yes, in fact, Sylvia Plath actually lived here as well, in 1951 or 1952. She even had a tantrum here where she threw all of her clothes out the window!ReplyDelete
You confused the two Barbizons- one is the womens' residence and the other is the hotel on 6th Ave. & 56th St.Your graphic is for the West side hotel.ReplyDelete
Here is another bit of Barbizon history. At one point Katharine Gibbs School in Manhattan had three floors of the Barbizon for its students. Women walked to Gibbs, back to the Barbizon for lunch, then back to class, then back to hours of homework.ReplyDelete
- AnonymousOctober 3, 2010 at 8:01 PM
Plath was at the Barbizon in the summer of 1953, while interning at a magazine. Greg, are you sure Plath actually threw her clothes out the window? That's definitely a scene in The Bell Jar, but the novel is not entirely autobiographical.ReplyDelete
- AnonymousOctober 3, 2010 at 8:01 PM
Plath was at the Barbizon in the summer of 1953, while interning at a magazine. Greg, are you sure Plath actually threw her clothes out the window? That's definitely a scene in The Bell Jar, but the novel is not entirely autobiographical.ReplyDelete


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Gossip Girl Season Finale Review: The More Things Change ...by Steve Marsi at . Comments
With one notable exception, Gossip Girl came full circle in its fifth season finale tonight.
Lily and Bart are married, with a spurned Rufus pining for the girl of his dreams. Dan, too, is back on the outside looking in, with no idealized visions of the Upper East Side or its denizens clouding his worldview.
Georgina is just waiting to stir up drama. Blair has her sights set on world domination. Chuck is reeling, desperate to escape from his father's shadow. Serena had barstool sex with Blair's boyfriend, then left town.
Nate is ... well, Nate. It feels like 2007 again, people!
Fortunately, for Chuck and Blair, "The Return of the Ring" was not just a return of previous near-misses. Cheesy gambling metaphors aside, when she showed up and told him she's all in, Chuck's face said it all.
Chair finally turned that corner, pointed squarely toward an epic endgame next season.
A quick review of Chuck, Blair and prior Gossip Girl season finales:
- Chuck ditches his new love last-minute in "Much I Do About Nothing."
- The couple gets together after graduation in "The Goodbye Gossip Girl."
- They were thisclose to getting engaged in "Last Tango, Then Paris."
- They reunited, only to part ways again in "The Wrong Goodbye."
Yeah, it's been a long, often painful road to get this far, with some aspects feeling repetitive. There's plenty of work left to be done, too. We can't forget that Chuck rejected Blair again at 8:50 EST tonight.
Realistically, though, everything up until this point had to happen. Even his rejection of Blair's advances before the buzzed-about, season-ending casino scene injected fresh life into the romance once more.
Chuck's past mistakes and misdeeds are well-documented, but that doesn't mean he's wrong about Blair. Nor was Bart, despite the callousness with which he cut Chuck loose. He deserved better than this.
She needed to be all in, too, and now she is. It'll be interesting to see how they get there, but it's hard to imagine Chair not getting together for real, and for good, as the series draws to a close next year.
The fairy tale ending Blair, and so many fans, have been dreaming about for so long is now within sight. More amazingly, tonight's crucial events felt somewhat organic ... well at least by Gossip Girl standards.
No one here's defending Bart for his lack of compassion, respect, empathy or truthfulness (guess he didn't change too much in hiding), but his actions did lead Chuck to make a decision of his own, for the right reasons.
Bart also gifted us with the prospect of Chuck and Jack Bass on the same side to take him down, and for that we are forever grateful. But most significantly, he cleared the way for a new, honest and equal Chair.
Dair fans, please remove your belt and shoelaces and give them to loved ones ASAP.
Their love was real, and Blair and Dan's relationship brought us so many great scenes. But there's probably no coming back from this one. Hold out hope if you like, but Blair made her choice, then she doubled down.
It has nothing to do with his cheating, which she presumably isn't even aware of (it was also a bit unclear, given all the scheming going on, if Blair even told Dan, or tried to tell him, that they were done).
If she really didn't tell Dan, after all he's done for her? Not cool. Plain and simple. I'd like to give B the benefit of the doubt here, but even if it did take place off screen, the fans would've liked more closure.
Regardless, her choice was irrespective of Dan and Serena's surprising sex romp. He's right when he says using her to forget his pain is different than the manipulative act of destruction she tried to initiate.
That was just wrong, and you can't help but feel a little bad for Dan in all this. He became collateral damage as Serena's Gossip Girl exploits unraveled so rapidly that her feud with Blair reached critical mass.
Is (or was) Serena really in love with Dan, as she claims? Or purely using his body and Blair's minions to ruin her now-former BFF? Somewhere in between? In any case, the extent of the fallout was dramatic.
Give Dan credit for not taking Serena back after realizing how he got played. Doing so would've been beyond pathetic, even if his kiss-off line to her was harsh. The maligned muppet has a backbone, who knew!
Where do any of them go from here? The writing was uneven this season, but the producers did a nice job of making the story arcs that concluded tonight matter with heightened emotional stakes and lasting repercussions.
Adrift and alone, Serena is riding the rails in more ways than one. Ironically, Blair's diary was leaked online, but it's S who burned just about every bridge known to humankind, while Queen B is off to rule Paris.
Their friendship may never recover, and clearly Bart's resurrection carried lasting repercussions. Chuck has been ostracized and left to fight for what's his. Rufus' marriage was annulled, just like that.
Much as certain thematic elements felt like deja vu, there's no hitting the reset button after this. Well, except maybe for Nate. He's pretty much back at square one, only wearing more suits. Bless his heart.
Clearly, opinions on the season finale and season overall will vary depending on how you feel about particular couples or relationships, but from a directorial standpoint, "The Return of the Ring" was a pretty good payoff.
There were twists, turns, consequences that matched the urgency of the building storylines and despite some eye-rolling moments - Blair listing off Dan and Chuck's respective traits to Eleanor; too many iPhone blasts, lies, gimmicks and convoluted ploys to even keep straight - it ended up being pretty darn entertaining.
This installment essentially blew up the nucleus of the show. Now, with 11 episodes to go before we close the book on the CW drama for good, we get to see it come together again. Bring it on.
Other side developments and burning questions from the Season 5 finale:
- William got Carol's half of Cece's estate transferred to Lola ... who give it all back to Ivy when she learned Lily was sabotaging Carol's defense, ordering her former impostor to take Lily down.
- Lola turned down the chance to live with Nate, but it was amicable at least. Guy was serious about her, too, but it looks like she's gone the way of vintage GG vanishing love interests past.
- Diana sent Nate a surveillance tape of their near-rendezvous with Gossip Girl two weeks back, and ... is Gossip Girl actually a dude? In a black hoodie? Shockingly, we didn't see his/her face.
- Will Dan channel his rage into the next work of literary brilliance? Or at least cutting his hair? Is Georgina really the best muse? Does he have any friends left on the UES except Nate?
- Does this mean Rufus will resume his music career?
- Any chance J (or V) makes a comeback next fall?
- Do people really throw divorce parties?
Time to turn it over to you. What did you think of the finale? Everything you thought it could be? A miserable failure? How do you see things playing out in the (unfortunately shortened) sixth and final season?
Share your comments with us below!
Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.Tags: Gossip Girl, Reviews
season finale: great! last two minutes! glad dair is history.
I am happy with the finale. Finally no heartbreak between Chuck and Blair. Dair was awful! There was no spark! It was dull boring and hard to watch. CHAIR FTW!
Dan is certainly not the GG. If it was, he would not needed Georgina to write a book. It seems that everyone forgot the end of season 2, when in some way explains about the GG. Then it was said that GG receive information from all the people, which then is filtered and then published on its website. GG is no one of the five main characters. GG is not one person, ie. it is one person who is administrator of GG site. But without the information that gets out of the ordinary people, GG is a nobody. So all those who sent information to the GG, is actually GG. Only question is who is the current target of GG?
Hmm...got cut off? Anyway, will Chuck and Blair somehow make their own way in the world, so they can thumb their noses at all the naysayers, especially Bart?
I thought it was a good finale :) Serena is back on a downward spiral (I'm still calling suicide!) Bart Bass--he might be all lovey-dovey with Lily now, but his memory is long. He doesn't forget that she was leaving him for Rufus. He's gotten his revenge against Rufus--wait for the revenge against Lily :) I believe he's stringing her along. Couple his efforts with Ivy's, and we've got fire! Blair needs a designer--could Little J be coming back? She doesn't strike me as a Waldorf designer, but Blair is going to want to put her own stamp on the line--what better way to do that than to revamp their styles? Georgina and Dan--in the end, Georgina will walk away unscathed. Dan, though--I'm thinking that he may think he's going to have the last laugh--but, in the end, he'll be put back in his place. In Brooklyn. Blair and Chuck (and Jack)--do they somehow get Bass Industries back from Bart? Will Bart die? Again. For real? Do they forget about the Bass billions and somehow make their own way? Can't wait for next season. I think that the writers will do it justice, after being lazy the last couple of seasons.
Season Finaly = Garbage
I was trying to say Doroto is married to a skinny tall man. They have access to the two great houses in the show. They could employ others who work as staff at the other locations throughout the show.
I think everyone has forgotten the email S sent to GG. The one where she offered to do anything to help her friend. And thereafter she does something totally out of [current] character. It might be the case that GG asked her to do it - to push B to the place where she'd finally make the choice S and GG both knew she would make (GG being privy to the knowledge as a result of having read B's diary pages). GG would be dark enough to request her act of contrition mirror her earlier act of selfishness.
Blair enjoying any kind of victory seems terribly shortsighted. Her concerns in the finale were with saving face in the NY social community and, as always, using persons she considers to be her inferiors. When was the last time you saw her do anything that wasn't self-motivated at the core?
Dan is consistently bitter, and has an apparent love for directing other people, so he could be a viable choice for GG. However, I think less obvious pairings shouldnt be precluded. Dorota is now married to a tall skinny man. Between the two of them they have access to two important households. And if they employ others who assist, that might extend to the waitstaff at all other important locations....
The finale was horrible. From the quick destruction of Dair (but I am fine with Chair), and then not even getting Derena, to the destruction of Lufus, to the destruction of Blair and Serena's friendship. And now why are they trying to destroy Lily, when she is right in this case? Her sister had sex with her husband and lied so many times! I want to see Ivy leave town or die or something...GG is just not working with her on the show, and the other storylines are suffering for it.
Here's something to think about, maybe? Sure the ending with Blair beside Chuck at the gaming table, adding a fortune to Chuck's bet. She may still love Chuck that she has his back yet is she really in love with him? I'm skeptical. I think that her coming to help him was making sure she would not be beholding to him because he had paid her dowry. Repaying a debt. What if Dan does still has her whole heart? Her and Dan didn't split up? The gossip girl blasts may all be taken out of context and everyone who read them made the wrong assumptions?
Dan really messed up assuming the worst and had sex with Serena. I may have to reach watch this episode. Does Blair know Dan had sex with Serena? Dan pairing up with Georgina is his second folly. I don't think we've seen the last of Blair and Dan as a couple. Next season may just surprise dair fans and upset chair fans.


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3d model of child's backyard inflatable waterslide with pool.
Model is completely textured. It contains standard 3ds max
materials and textures 2048 x 2048 pix size.
UVW coordinates of objects are unwrapped
and edited carefully (separated by materials).
Model is subdivided. Mesh Smooth modifier was assigned
before preview render (separated by smoothing groups).
Modifier stacks are not collapsed.
Original format is 3ds Max2008.
ZIP-archives of original formats contain scenes with
materials settings for scanline/mental ray and V-Ray renders.
Archives with other (none-original) formats are contain
Low, Mid and Hi poly models meshes.
All textures saved.
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waterslide pool plaything toy attraction playground children play covers baby kids inflatable backyard slide water outdoor basin recreation joy fun game


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Old South Jersey Glass Paperweight Wig Stand
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- $370.00
- Quantity Available: 1
Wonderful old Millville, NJ area glass paperweight wig stand or mantel ornament. The setup is pierced with five elongated icepick bubbles. Small bits of aventurine glass highlight the overall coloring of soft yellow and green. The top is heavily faceted with 33 printies of varying sizes. The cutting strikes me as being similar to the faceting seen on good New England Glass Company paperweights. The weight is raised on a baluster form pedestal and a foot. The glass is very heavy and of the finest quality. A similar wig stand/mantel ornament is pictured in Newell's "Old Glass Paperweights of Southern New Jersery".
Origin: Millville, NJ area, late 19th century. Condition: very good, a fleabite on the edge of the top printy, another about a third of the way down the crown, and another on the edge of the foot; a small moon on the perimeter of the weight. Size: 6" tall; foot 3-1/16" diameter.
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Nature's Miracle Advanced Stain & Odor Remover
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- 24-oz bottle
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- 1-gal
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Nature's Miracle Advanced Stain & Odor Remover, 1-gal bottle
Deep-set odors and overlookes stains might be too much for the average pet product to clean, but they're no match for Nature's Miracle! All-natural Nature's Miracle Advanced Stain & Odor Remover lifts away organic stains from urine, feces, vomit, grass, dirt, and other common pet-related stains from carpets, kennels, and any other surface.
Key Benefits
- Penetrates deep into carpet pads and subfloors
- Neutralizes organic odors
- Quick drying with a clean, fresh scent
- Works on old stains
|Item Number
Stain Removal: Wipe away any excess stain-causing material, then soak the surface thoroughly with Nature's Miracle Advanced Formula Stain and Odor Remover. Wait 5 minutes, then wipe away stain with a cloth. For tough stains, use a stiff, bristle brush. If the stain is not completely removed, re-soak area and allow Nature's Miracle Advanced Formula Stain and Odor Remover to work for 1 hour before wiping with a cloth. Keep the product away from children and pets and do not allow pets onto the treated area until it is completely dried. Odor Elimination: Thoroughly soak the entire area with Nature's Miracle Advanced Formula Stain and Odor Remover. For carpets, apply enough to reach the urine penetration in the pad and floor. This may mean lifting the carpet and applying directly to the pad and floor. Allow the product to air dry. Depending on air circulation, carpets and upholstery may take up to 2 weeks to dry completely. If after 2 weeks there is still an odor, Nature's Miracle Advanced Formula Stain and Odor Remover has not reached ALL of the odor-causing material. Pinpoint odor source and repeat cleaning process. Keep the product away from children and pets and do not allow pets onto the treated area until it is completely dried. Laundry: Saturate areas of fabric affected by stain and odor with full-strength product, then wash as usual.
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Nature's Miracle Advanced Stain & Odor Remover Customer Reviews
Nature's Miracle Advanced Stain & Odor Remover 42 42
Awesome! This is what it really is, a miracle. I got a lot of accidents in the house. This has been my go to for getting the odor and stain out. It works. I tried other cleaning products and the odor comes back after a while. When I started using this, I have never have to deal with stinky odors in the house. Amazing! December 15, 2012
BEST PRODUCT EVER!! After having some renters move out, we discovered that they had pets. Several. 2 dogs and 6 cats to be exact. You can imagine the smell in the house. I tried everything and nothing worked. A friend recommended this so I thought "what do I have to lose?" Am I glad!! ONE treatment of this solved my problem! The smells are gone. I did do like others said, and applied it heavily. I actually used a garden sprayer and covered all of the floors and lower walls. Truly a Miracle!! August 13, 2013
product works very well for odors ive used this product for ten years. i tried other similar products but this one definately works the best. i have older dogs who are having more frequent accidents, so this is the first time ive tried the advanced formula. always have great results September 4, 2013
Works,Takes Odor Away! Was really surprise,First time user.Had used many brands. But this Really Work!! September 7, 2013
Very effective When I used the regular Nature's Miracle my dog would still have accidents over the spots I already cleaned. With this he finally stopped having accidents in the house. March 5, 2014
Excellent product We are so happy with the stain remover the only down side is the high price. Definitly recommend January 17, 2013
Nothing better short of a professional steam clean! With three cats and two dogs there is rarely a day that doesn't require cleanup. I have relied on this product for well over five years but this is the first time I have ordered through Chewies. The price was $15 cheaper for the gallon size than at the big box retailer I usually purchase from. As usual, Chewy delivers more than expected! February 2, 2014
Very effective I was pleasantly surprised by how effective this product is. I have a new rescue dog who isn't house trained yet, and I bought it to help with a few stains she left. The day after it arrived, my mastiff got into the pantry and ate 14 rolls of Ritz crackers (!) and got really sick. Picture vomit and diarrhea in copious, stinky quantities. I used this product -- a LOT of it -- and although it didn't completely remove the stain, it made it much less visible. The odor fighting quality was great, too: one bout of diarrhea was in a small room, and the odor was so strong I kept gagging while I cleaned it up. The odor was lingering, but it was completely gone after I used the product. In a 3-dog, 2-cat household that also has fosters rotating through, I think I'll put the big bottle on our list for every month. Highly recommended. December 22, 2013


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Our green pool cleanup will completely remove all traces of algae
from your pool.
- All chemicals (Chlorine, Muriatic Acid, Bicaronate, Stabilizer, Etc.)
- Brushing the sides, steps and bottom of the pool during each visit
- Backwashing of the Sand , D.E. filter and Cartridge filter
- Vacuum the pool as needed.
- Cartridge filters and D.E. filters will need at least one cleaning during the cleanup process
- Pools with filtration problems and/or poor water circulation may require additional repairs (Not Included in above price)
- A 50% deposit for chemicals is required prior to the start of service and will be applied to the total service cost
- Draining the pool
- Chemical Wash
- Refill the pool
- Balance the water chemistry (Price Does NOT Include Salt)
- This service is not recommended for plaster pools during the summer months as damage may result.
This service includes:
Chemical Wash (Chlorine Bath) Cost: Call for price.
In some cases the pool may require a chemical wash to kill and remove
tough spots of algae.
Please feel free to contact us if you have any questions about our services..


text: The Secret Intelligence Service (SIS) is responsible for supplying the British Government with foreign intelligence. It is frequently referred to in the mass media and popular parlance by the name MI6, a name used as a flag of convenience during the Second World War when it was known by many names. Alongside the internal Security Service (MI5), the Government Communications Headquarters (GCHQ) and... Full Article At Wikipedia.org


text: ESPN Feed: joe kaiser http://assets.espn.go.com/i/tvlistings/tv_espn_original.gif ESPN en-us 10 ESPN Inc. http://espn.go.com/ Copyright 2010 ESPN Inc. ESPN Insider's "Countdown to Madness" series is previewing the top five seeds in each of the four regions in Joe Lunardi's preseason 2013 NCAA bracket. This is the entry for Duke, No. 4 in the East (Washington).]]> September 27, 2012 04:57:07 PDT


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In picture #2 you can see what I was whipping around to look at in picture #4. That small brown blur in the background is a chipmunk crossing the road. My girls in were in the window hollering, "SQUIRREL! SQUIRREL!". How could I NOT look?
In other news, I've decided to do more with my time (I know, right?) and I checked out an audio book from the library. I sit in the car for a least an hour and a half each day, might as well. Anyway, my first foray has been pretty good (it's The End of the Wasp Season by Denise Mina if you're interested.) I've noticed 2 things though:
1. I arrive at my destination wondering just how in the hell I got there.
2. Since the narration is done by a Scottish woman, there is a few disorienting moments after exiting my vehicle where I expect everyone to be speaking in a Scottish accent.
I'm still deciding if this is really something I should be doing. . .
thrifted top (similar, similar)
thrifted purse (similar)
F21 skirt
Target flats (I love this cap toe version, or here's a more affordable option)
AE necklace


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December 21, 2014
JOHNSON COUNTY, Ky. (WYMT) - The blizzard in the northeast caused some travel issues for Johnson County Sheriff's deputies trying to extradite a man back to Kentucky.
Robert Slone was the final arrest to be made from a drug roundup in 2011. Slone was located in Reno, Nevada, through the electronic warrants program. Sheriff's Deputy David Pridemore explains, "You run a drivers license and if they have a warrant it sends up a red flag to the law enforcement agency, it doesn't have to be in Kentucky it can be any state."
So the deputies traveled more than 2,000 miles to make that final arrest, but the their six hour trip back to the bluegrass turned into more than 30 hours.
Sheriff's Deputy Terry Tussey explains the ordeal, "We got to Dallas and due to the weather situation and some unforeseen things we couldn't go on the flight we were scheduled for so we had to wait til this morning and catch another flight."
After not sleeping for nearly two days the deputies are happy to be home and although it was an exhausting process officials say they are happy to have successfully arrested 100% from the 2011 drug roundup.
Slone has been booked and is being held at the Big Sandy Regional Detention Center.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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Mexican Migration May Be Over
Is mass migration from Mexico to the United States a thing of the past?
At least for the moment, it is. Last May, the Pew Hispanic Center, in a study based on U.S. and Mexican statistics, reported that net migration from Mexico to this country had fallen to zero from 2005 to 2010.
Pew said 20,000 more people moved to Mexico from the United States than from there to here in those years. That's a vivid contrast with the years 1995 to 2000, when net inflow from Mexico was 2.2 million people.
Because there was net Mexican immigration until 2007, when the housing market collapsed and the Great Recession began, it seems clear that there was net outmigration from 2007 to 2010, and that likely has continued in 2011 and 2012.
There's a widespread assumption that Mexican migration will resume when the U.S. economy starts growing robustly again. But I think there's reason to doubt that will be the case.
Over the past few years, I have been working on a book, scheduled for publication next fall, on American migrations, internal and immigrant. What I've found is that over the years this country has been peopled in large part by surges of migration that have typically lasted just one or two generations.
Almost no one predicted that these surges of migration would occur, and almost no one predicted when they would end.
For example, when our immigration system was opened up in 1965, experts testified that we would not get many immigrants from Latin America or Asia. They assumed that immigrants would come mainly from Europe, as they had in the past.
Experts have also tended to assume that immigrants are motivated primarily by economic factors. And in the years starting in the 1980s, many people in Latin America and Asia, especially in Mexico, which has produced more than 60 percent of Latin American immigrants, saw opportunities to make a better living in this country.
But masses of people do not uproot themselves from familiar territory just to make marginal economic gains. They migrate to pursue dreams or escape nightmares.
Life in Mexico is not a nightmare for many these days. Beneath the headlines about killings in the drug wars, Mexico has become a predominantly middle-class country, as Jorge Castaneda notes in his recent book, "Manana Forever?" Its economy is growing faster than ours.
And the dreams that many Mexican immigrants pursued have been shattered.
You can see that if you look at the statistics on mortgage foreclosures, starting with the housing bust in 2007. More than half were in the four "sand states" — California, Nevada, Arizona and Florida — and within them, as the Pew Hispanic Center noted in a 2009 report, in areas with large numbers of Latino immigrants.
These were places where subprime mortgages were granted, with encouragement from Fannie Mae and Freddie Mac, to many Latinos unqualified by traditional credit standards.
These new homeowners, many of them construction workers, dreamed of gaining hundreds of thousands of dollars as housing prices inevitably rose. Instead, they collapsed. My estimate is that one-third of those foreclosed on in these years were Latinos. Their dreams turned into nightmares.
We can see further evidence in last month's Pew Research report on the recent decline in U.S. birthrates. The biggest drop was among Mexican-born women, from 455,000 births in 2007 to 346,000 in 2010.
That's a 24 percent decline, compared with only a 6 percent decline among U.S.-born women. It's comparable to the sharp decline in U.S. birthrates in the Depression years from 1929 to 1933.
Beneath the cold statistics on foreclosures and births is a human story, a story of people whose personal lives have been deeply affected by economic developments over which they had no control and of which they had no warning.
Those events have prompted many to resort to, in Mitt Romney's chilly words, "self-deportation." And their experiences are likely to have reverberations for many others who have learned of their plight.
Surges of migration that have shaped the country sometimes end abruptly. The surge of Southern blacks to Northern cities lasted from 1940 to 1965 — one generation. The surge of Mexicans into the U.S. lasted from 1982 to 2007 — one generation.
The northward surge of American blacks has never resumed. I don't think the northward surge of Mexicans will, either.
Michael Barone, senior political analyst for The Washington Examiner (www.washingtonexaminer.com), is a resident fellow at the American Enterprise Institute, a Fox News Channel contributor and a co-author of The Almanac of American Politics.
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Quick, hide under the covers. The nation's storyteller, Barack Obama, unveiled a frightening new fable on the Internet intended to


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Obama's Offer on Fiscal Talks Is "Insanity"
Photo Credit: © SVLuma/ Shutterstock.com
Stay up to date with the latest headlines via email.
President Obama and House Republicans appear to be closing in on a deal to avert the fiscal cliff, but liberals are not happy with it.
Late last night, the White House offered a plan with two major concessions to Republicans. First, it would hike taxes on the wealthy, but only on income above $400,000, instead of the current $250,000 threshold. Second, and far more controversially, Obama offered to change the formula used to calculate Social Security benefits in a way that would cut outlays to seniors slightly while saving the program $225 billion over a decade.
The reaction from liberals, who have been demanding all along that social safety net programs be off the table, was swift and fierce. "This is a cut affecting every single beneficiary — widows, orphans, people with disabilities and many others. It is a cut which hurts the most those who are most vulnerable: the oldest of the old, those disabled at the youngest ages, and the poorest of the poor. Perhaps fittingly, this will be done during the holiday season, when the American people are distracted," Nancy Altman, the founding co-director of the advocacy group Social Security Works, said in a statement.
"They will cut Social Security not openly but by stealth — through a cruel cut known colloquially as the chained CPI," she added.
The CPI, or cost of living index, is used to make sure benefits keep pace with inflation, but there are lots of different ways to calculate it. The current measure, called the CPI-W, is generally accepted to overestimate inflation, but the liberals say the proposed alternative, the chained CPI, is too stingy. The chained CPI assumes seniors will adjust their buying habits in response to price shifts (e.g., if the price of oranges goes up, they'll buy more apples), so they should be able to afford to take a haircut on benefit checks. But liberals say that seniors often barely make ends meet with current benefit levels, so cutting them more would be devastating.
Democratic Rep. Keith Ellison, the chairman of the Congressional Progressive Caucus, noted that 102 House Democrats have already said that Social Security changes should be kept off the table in these negotiations. "Everyone has a grandparent, a friend or a neighbor who relies on the Social Security benefits they earned to pay for medical care, food and housing. A move towards chained CPI would be a long-term benefit cut for every single person who receives a Social Security check," he said in a statement.
The chained CPI would cut about $6,000 worth of benefits in the first 15 years of retirement for the average 65-year-old, and $16,000 over 25 years. "This change would be devastating to beneficiaries, especially widowed women, more than a third of whom rely on the program for 90 percent of their income and use every single dollar of the Social Security checks they've earned," Ellison added.
Rep. Barbara Lee, a former Black Caucus and Progressive Caucus co-chair, responded to the news on Twitter: "Reducing COLA is a Social Security benefit cut. Any deal that cuts Social Security, Medicare, or Medicaid benefits is unacceptable."
Outside progressive groups, meanwhile, have been threatening to mobilize against the White House if entitlement cuts are included in a deal. "It would be a massive betrayal if the White House went back on its promise to both protect Social Security benefits and end the Bush tax cuts for the wealthiest 2 percent of Americans," Becky Bond, political director of CREDO, said in a statement
CREDO, the grass-roots organizing group funded by its cellphone business, has been increasingly active, mobilizing in 10 key House races during the election and leading a march against the NRA yesterday. "When it comes to the fight necessary to make his campaign promises a political reality, the president has said it's up to us to 'make him do it.' We're putting the president on notice that we will fight to stop any deal — including the one on the table right now — that goes back on his promise to oppose cuts to Social Security benefits and to end the Bush tax cuts for people making over $250,000 a year," Bond added.
Stay up to date with the latest headlines via email


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Andrew Cuomo on Education
Democratic Governor
Let's invest in the future; let's reimagine our classrooms for the next generation; let's have the smartest classrooms in the nation because our children deserve nothing less than the best. Let's go to the people of this state, with a bond referendum with a smart schools initiative lets invest $2 billion in providing the technology of tomorrow today to bring our classrooms up to speed.
Therefore, I am proposing two competitive funds. First, a $250 million school performance fund for districts that proportionally increase performance in the classroom. The second will be a $250 million administrative efficiency fund for districts that can find demonstrative savings through efficiencies.
Vouchers for private school are not the panacea that the Republicans would have people believe, and they threaten to undermine our existing public schools. Charter schools hold selective promise, but are only a part of the answer. We must embrace comprehensive reform of our public school system that does not continually seek, as the Republicans often do, simply to remove children from, or undermine, those systems.
We must be willing to close persistently failing schools that have not responded to help, in favor of new schools with new staff and new approaches. Democrats are the party of public education and therefore we must be the party that demands the most from public education.
|Other governors on Education:
|Andrew Cuomo on other issues:
NY Gubernatorial:
Bill de Blasio
Howie Hawkins
Kathy Hochul
Mike Bloomberg
Rob Astorino
Zephyr Teachout
NY Senatorial:
Charles Schumer
Kirsten Gillibrand
Gubernatorial Debates 2014:
AL: Bentley(R) vs.Griffith(D)
AR: Ross(D) vs.Hutchinson(R) vs.Griffin(R,Lt.Gov.)
AZ: Ducey(R) vs.DuVal(D) vs.Mealer(AE) vs.Gilbert(L) vs.
CA: Brown(D) vs.Kashkari(R)
CO: Hickenlooper(D) vs.Beauprez(R) vs.
CT: Malloy(D) vs.Foley(R) vs.Walker(R,Lt.Gov.)
FL: Scott(R) vs.Crist(D) vs.Snitker(L,Lt.Gov.)
GA: Deal(R) vs.Carter(D) vs.Hunt(L)
HI: Ige(D) vs.Aiona(R) vs.
IA: Branstad(R) vs.Hatch(D) vs.
MA: Coakley(D) vs.Baker(R) &Polito(R,Lt.Gov.) vs.
ME: LePage(R) vs.Michaud(D) vs.Cutler(I)
MI: Snyder(R) vs.Schauer(D)
NM: Martinez(R) vs.King(D)
NY: Cuomo(D) &Hochul(D,Lt.Gov.) vs.Astorino(R) vs.Hawkins(G) vs.
OK: Fallin(R) vs.Dorman(D)
PA: Corbett(R) vs.Wolf(D) vs.
Up for re-election 2014:
AK-R: Sean Parnell
AL-R: Robert Bentley
CA-D: Jerry Brown
CO-D: John Hickenlooper
CT-D: Dan Malloy
FL-R: Rick Scott
GA-R: Nathan Deal
HI-D: Neil Abercrombie
IA-R: Terry Branstad
ID-R: Butch Otter
IL-D: Pat Quinn
KS-R: Sam Brownback
ME-R: Paul LePage
MI-R: Rick Snyder
MN-D: Mark Dayton
NH-D: Maggie Hassan
NM-R: Susana Martinez
NV-R: Brian Sandoval
NY-D: Andrew Cuomo
OH-R: John Kasich
OK-R: Mary Fallin
OR-D: John Kitzhaber
PA-R: Tom Corbett
SC-R: Nikki Haley
SD-R: Dennis Daugaard
TN-R: Bill Haslam
VT-D: Peter Shumlin
WI-R: Scott Walker
WY-R: Matt Mead
Term-Limited or Retiring 2014:
AR-D: Mike Beebe
AZ-R: Jan Brewer
MA-D: Deval Patrick
MD-D: Martin O'Malley
RI-I: Linc Chafee
TX-R: Rick Perry
Civil Rights
Foreign Policy
Free Trade
Govt. Reform
Gun Control
Health Care
Homeland Security
Local Issues
Social Security
Tax Reform
Election 2013:
New Jersey:
NJ-R: Chris Christie (won)
NJ-D: Barbara Buono (lost)
VA-R: Bob McDonnell(Retiring)
VA-R: Ken Cuccinelli (lost)
VA-D: Terry McAuliffe (won)


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Kanye West and Russell Crowe - Russell was hanging out in the studio during the Watch The Throne sessions. They should have let him spit.
Pics via WENN/AP
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Is New York's Startup Scene a 'One-Trick Pony'?
The latest CB Insights report on venture capital investment just dropped, and we've spent the morning digging into the data. Local entrepreneurs might want to sit down, because this is gonna sting a little.
Overall the quarter was a big one, with 812 deals adding up to $8.1 billion. The report points out that's the biggest single quarter since the dot com days. (And what with Digg and Yahoo dominating the headlines, you'd be forgiven for getting a little confused on the year.) Seed stage investments made up 22 percent of those deals, which fits with our anecdotal sense that startups are springing up like mushrooms after a rainstorm.
In terms of deal volume, New York held onto the number-two spot for the second quarter in a row. A big part of that is digital: The report calls California and New York a "two-headed monster on the internet front," and points out that "larger funding deals enable Florida and Washington to challenge Massachusetts for the #3 spot." Read More


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BBB Hip chapter preview and behind the scenes photos
November 29, 2011 by The Hip Event
Filed under Blog
If you don't already know, our Maria Cucciniello was asked to share her knowledge and expertise on creating lasting buzz for your business for the folks over at Woodpecker Press. They're putting together a fantastic book called Big Bold Business Advice from 100 New Jersey Business Women Business Owners, and Maria has contributed a chapter. [...]
The Hip Event's Maria Cucciniello Dishes On Event Marketing & Other Hip Expertise
November 22, 2011 by The Hip Event
Filed under Blog
Our Maria recently wrote up a little something to get all those event marketers out there to think more on their toes and to educate those who might not know much about what we do. Click on the quick clip below to read the original post. Annnnnd if you haven't seen it yet, Maria's also [...]
The Hip Event's Maria Cucciniello Building Buzz in The Record
July 19, 2011 by The Hip Event
Filed under Blog
This past Sunday (7/17/11), The Bergen Record ran an article on our very own Maria Cucciniello! The Q&A style article by Joan Verdon, showcases how and why Maria and The Hip Event are at the top of the list when it comes to PR & New Jersey Reality TV. To learn more about The Hip [...]


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Nico Rosberg reckons the Yeongam circuit "suits" his W03 despite overheating the rear tyres.
Rosberg and his team-mate Michael Schumacher finished Friday's practices for the Korean Grand Prix seventh and fifth on the timesheets respectively.
Mixing it behind the Red Bulls with the Ferraris and McLarens, Rosberg says Mercedes have cause to be happy.
"It's been a good day for us; I think we've made some good progress," said the German.
"Michael had some new things on the car - some small things to try - and they seemed to work well.
So I think maybe a little bit of an upward trend for us today and going in the right direction on this track [which] I think suits us a little bit more."
As for tyre wear, Rosberg believes Mercedes are looking good despite a bit of overheating of his rear Pirellis.
"Tyre-wise it's wearing quite well. I mean we're overheating [the tyres] a little bit in the long run, but it's okay. I think this circuit suits our car quite well."
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testing my LC-A+ after a maintenance, needed to be cleanThis photo was shot on film. Taken by qrro with a Lomo LC-A loaded with Kodak Ultramax 400 (35mm) film in Lima, Peru. These tags describe this photo: peru, lima, lc-a, kodak, ultra, max, 400, testing, friends, color, negative, c41, bar, beer, fun, night, epson, and v500. Date: 2012-04-26. Time: Night. This photo can be found in the album Testing my LC-A+.
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The Daily Troll: State of Downtown. Suburbs growing up. Rodney Tom bashes Seattle again.
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"Yes, I have smoked crack cocaine. There have been times when I've been in a drunken stupor. That's why I want to see the tape. I want everyone in the city to see this tape. I don't even recall there being a tape or video. I want to see the state that I was in."—Toronto Mayor Rob Ford acknowledging that he smoked crack, but refusing to resign from his office.
"Over the next four years most Democrats and Republicans want to make Virginia a model of pragmatic leadership. This is only possible if Virginia is the model for bipartisan cooperation."— Virginia Gov.-elect Terry McAuliffe after defeating Virginia Attorney General Ken Cuccinnelli in the state's gubernatorial election.
"This chapter is behind me. And I am focusing on the challenges ahead, and there are plenty of challenges." —Israeli former Foreign Minister Avigdor Lieberman after being found not guilty of all charges in a graft trial. He claims he has been persecuted by overzealous prosecutors for 17 years.


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"Loved this recipe! I added the brown sugar/mustard mix in the middle like one of the reviews said and it was OUT OF THIS WORLD. Will definitely keep making this one!"""


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Jay Buim is an adopted, delinquent filmmaker from the great state of New Jersey. He graduated from Pennsylvania State University in 2005 with a degree in film. Shortly after he spent two years in Los Angeles working on the documentary "Beautiful Losers," he relocated to New York. In 2009 his first feature film "Todd P Goes to Austin" was released, which documented America's underground, do-it-yourself music scene. The film received numerous accolades and was screened worldwide. Following the release of "Todd P Goes to Austin" on DVD Jay became the Producer for Nylon TV. Currently he is the video fellow at Creative Time and has begun production on his new documentary, an exploration of New York artists and social fixtures of yesteryear. He enjoys dumplings and riding his bike.


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To illustrate how seriously we take this, whilst other poker rooms continued to allow American customers to play on their sites after the 'UIGEA' was passed in 2006 (which applied to US citizens only) we did not take a single one. We love the game of poker as much as our players and we want everyone to be able to enjoy the game but we will never offer a service to anyone that may be deemed illegal.
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Did Marc Jacobs and Lorenzo Martone Split?
Say it ain't so.
Skip to content, or skip to search.
Skip to content, or skip to search.
Say it ain't so.
His and hers fashion blogs! Couldn't you just die?
It's disgustingly cute. Brace yourself.
Her latest squeeze appears to be Alex Greenwald.
If that is true, she would be the best-dressed baby ever.
Marc to Lorenzo backstage at the Louis show: "I've been looking all over for you. I'm afraid when I don't see you!"
And we have the screen grab to prove it!
The 'Post' says their relationship is on the rocks, but we beg to differ.
He's under investigation for assaulting a paparazzi. Also, Madonna gave him a shot in his rear.


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we love to make new creations so since the real horses are in the barn we made on to ride in the snow
riding into spring on a snow day
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ASHEVILLE, N.C. (AP) - A Buncombe County man has been charged with killing his wife.
Forty-year-old Brian Walter Jones has been charged with first-degree murder in the death of 43-year-old Lynn Friedrich Jones.
Family members found Jones' body when they went to a mobile home late Wednesday morning.
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At the moral high point of I Now Pronounce You Chuck & Larry, there's still this: Chuck and Larry are grossed out by a kiss. In the midst of speeches about tolerance as well as yuks wrung from jokes about the fat that clings to widower Larry (Kevin James) and the women who cling to single guy Chuck (Adam Sandler) the hetero firemen, who are faking a homosexual domestic partnership for health insurance coverage for Larry and his kids, are urged to express their love for one another, at what is surely the weirdest fraud-inquiry hearing ever to take place even in weird-friendly Brooklyn. Whereupon the two pucker like they're facing the gallows; the prospect is just that yucky.
So if I'm reading the ''message'' right in this lumbering, time-warp disco of a comedy about the heroism of firefighters, the preciousness of male bonding, the sanctity of family, and the glory of Jessica Biel's proudly real breasts, it's that gay men are marvelous, exotic, and hilarious creatures who have every right to equality under the law. And that it's very hurtful when they're discriminated against. Or beaten up. Or even shunned in communal firehouse showers, where straight colleagues are scared to pick up a dropped bar of soap. But if it's all the same to you, being straight is, you know, more regular. And, like, whew.
Perhaps I'm reading too much into a slab of honking Sandler comedy, made for an audience already predisposed to laugh when, early in the story, Chuck and Larry rescue an obese bed-bound man during a fire. (The massive fellow rolls on top of them! And then farts!) Or when Chuck finds himself attracted to Alex (Biel), the lawyer defending the couple against a suspicious insurance fraud investigator (Steve Buscemi), and gets invited to assess Alex's assets, ''girlfriend'' to girlfriend. (Tootsie got there a quarter century ago, with more class.) But I can't shake the musty odor of comic overexertion coupled with Hollywood nervousness that wafts up from every scene. When the pair go shopping for items to gay up their home, naturally they grab lubricating gel from the personal products shelf. Don't all The Gays? That the movie, directed by Happy Gilmore helmer Dennis Dugan, received a script revision by classy Sideways talents Alexander Payne and Jim Taylor does dismayingly little to up the sophistication quotient.
Anyhow, it's not until Chuck and Larry actually experience discrimination that they begin, in their audience-safe, Neanderthal way, to understand what victimhood feels like. Myself, I felt victimized by the stereotype shtick of reliably grating Rob Schneider as a Canadian-Japanese wedding-chapel minister from SNL castoff hell. But maybe that's just because this movie encourages sensitivity by hitting everyone over the head with its humor hammer.


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mrcollinswifeon April 23, 2012 Link
+1(((Hug)))Flag Justguessingon October 22, 20120I am so sorry. What a strange story. Are you OK now?Flag deSitter33on July 07, 20140That is the most heartbreaking story, yet somehow hopeful. Sure, it could've been a funny little coincidence that that song came on the radio right after you signed for your house, and no one will ever know for sure if it was or wasn't, but wow, I was bawling when I read that. Good luck to you.Flag jmyers95662on August 29, 2014