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Inspections, Compliance, Enforcement, and Criminal Investigations
Cezayirli, R. Cem, M.D. 11-Dec-01
Food and Drug Administration
Rockville, MD 20857
By Certified Mail - Return Receipt Requested
Warning Letter
R. Cem Cezayirli, M.D.
Haynes Neurosurgical Group, P.A.
801 Princeton Avenue, S.W., Suite 310
Birmingham, Alabama 35211
Dear Dr. Cezayirli:
During an inspection that ended on October 3, 2001, Ms. Patricia Smith, an investigator from the Food and Drug Administration (FDA), visited Your office to examine records relating to your clinical study of an investigational activated cell product. The title of the study is "Autologous Programmable Dendritic Cell Vaccine." This letter addresses your duties as both the sponsor of the research and the clinical investigator responsible for the
enrollment and administration of the investigational activated cell product to human subjects. The inspection is part of FDA?s Bioresearch Monitoring Program that includes inspections designed to review the conduct of research involving investigational new drugs.
The inspection also included a review of your study of an investigational medical device. The inspectional findings from the device study are discussed later in this letter.
It bears noting that the inspection revealed information about your use of the investigational activated cell product during the period from 1997 through [redacted], before you submitted the [redacted] Investigational New Drug Applications (INDs) to FDA. Our comments on your research during that period are listed on pages three to five of this letter.
We determined that during the period since [redacted], you violated regulations governing the proper conduct of clinical studies involving investigational new drugs as published under Title 21, Code of Federal Regulations (CFR), Part 312 available at http://www.access.gpo.gov/nara/cfr/index.html " The applicable provisions of the CFR are cited fo; each violation listed below.
- You failed to permit an FDA officer to have access to and copy and verify records and reports relating to a clinical investigation conducted under Part 312. [21 CFR S 312.58(a)].
- You failed to withhold administration of an investigational new drug until an IND is in effect. [ 21 CFR SS 312.20, 312.40(d), and 312.50 ].
- You failed to maintain adequate case histories of individuals treated with the investigational activated cell product including the number of cells administered to each injection site for each subject.
a. During the inspection you refused to identify the name(s) or location(s) of laboratory (ies) manufacturing the investigational activated cell product. In the INDs you submitted to FDA [redacted] in you state that the laboratory facilities are located ;n the same building as your office, yet the inspection revealed that your laboratory was converted into office space in [redacted], one year before you submitted the first IND to FDA.
b. You failed to provide access to the records for each subject you described in your Investigational New Drug Applications (INDs). You submitted summaries of these subjects to the INDs as required by 21 CFR S 312.23(.a) (3) (ii) to describe the previous human experience with your proposed investigational activated cell product. Yet, during the inspection you were unable or refused to provide the medical records of one subject for verification and copying, and of two subjects for copying. The protocol assures FDA that "the informed consent documents, patient histories, and records of vaccination and outcome will be handled and stored within the office suite of Haynes Neurosurgical Group P.A."
c. By your own admission, you initiated the protocol for "maybe six" new subjects outside the U.S. after you became aware that the study must be conducted under an IND, yet you declined to identify or provide records for these subjects.
You administered the investigational activated cell products to subjects [redacted] and 5 in the [redacted] when there was no IND in effect even though you were aware that an IND was required to conduct the research. You submitted your first IND to FDA in [redacted]. In [redacted]. You administered the product to subject [redacted] in July 2000, and to subject [redacted] in October and November 2000, without having an IND in effect. See also item 1C above.
3. You are promoting investigational drugs in violation of 21 CFR 312.7(a)
Sponsors may not represent in a promotional context that an investigational new drug is safe or effective for the uses that are under investigation. Your web site at http://www.immuno-genetics.com is promoting your study and contains the following examples of therapeutic and safety claims about your study:
"Years of research have developed a unique procedure with the use of Dendritic cells that provides a cure through arousing the body?s own immune system to respond to cancer that has normally been effective in hiding from the body?s immune system." "This patented procedure will detect and destroy the majority of cancer types using natural methods that produce no side harmful effects."
"As you can see from our survivors page, we have had good success with some of the worst tumors known to man. Basically, of the 3 original patients that we treated more than 3 years ago, 2 are still alive and well." This statement is misleading because it fails to describe that several other subjects died while participating in the research. Comments on your research during the period from 1997 until [redacted].
During the period from 1997 to [redacted], before you submitted an Investigational New Drug Application (IND) to FDA/ YOU were responsible for the following conduct:
1. You charged the subjects money for the investigational activated cell product.
Please note that charging for an investigational drug under an IND is not permitted without the prior written approval of FDA under 21 CFR 312.7(d).
3. You improperly used the Baptist Medical Center form entitled "Consent to Operation or Other Procedure" to obtain consent from subject [redacted] for the procedure Dendritic Cell Vaccine." On July 27, 1999, you performed surgical debulking of subject [redacted] tumor at Baptist Medical Center. On August 7, 1999, after the surgery, subject [redacted] signed the consent form. You administered the vaccine to subject [redacted] on August 7, 1999, and August 24, 1999.
This is an improper use of the institution?s form because it implied to the subject that the institution had approved the research. You did not have the institution?s approval to conduct the research. The Baptist Health System Institutional Review Board (IRB) informed you on [redacted] that you were not permitted to involve the institution in the research without full review and approval by the IRB.
4. The consent forms you submitted to FDA in [redacted] are misleading because they imply that the Baptist Health System is a willing participant in the research. As described in item C above, at the time you submitted the INDs you did not have IRB approval to conduct any aspect of this study at that institution.
5.You failed to provide a copy of the protocol to the Immunogenetics? Investigational Review Board during their review of your study, citing concerns about proprietary information.
6. You failed to obtain IRB approval of at least four different consent forms utilized in your clinical study. Neither the Immunogenetics? IRB nor the Baptist Health Systems IRB reviewed and approved the consent forms listed below. In additional, none of the following consent forms contain the elements of informed consent required by 21 CFR 5 50.25:
a. The consent form entitled "Vaccine Consent Form " that was signed by subjects [redacted]
b. The consent form entitled "Brain Tumor Study Immunogenetics Patient Consent Form" that was signed by subjects [redacted]
c. The consent form entitled "Consent to Operation or Other Procedure" that was signed by subject-; see item D above.
d. The consent form that was signed by subject [redacted] that released you and Immunogenetics, Inc. from any consequences of drawing blood, and from any future claims for the blood or related products in the future.
7. You enrolled subjects who did not have brain tumors, and therefore were not eligible to participate according to the study concept conditionally approved by the Immunogenetics? Investigational Review Board meeting held [redacted]. In the IND you submitted to FDA in [redacted], you report that you administered the activated cell product to subjects with other neoplasms, including osteosarcoma, colorectal cancer, and neurofibrosarcoma.
8. You used a brain tumor extract from a deceased subject to manufacture the investigational activated cell product for another subject. During the inspection you acknowledged that the use of another person?s tumor tissue would result in risk to subjects. There are no records that you performed any quality control testing to detect and prevent the transmission of adventitious agents from the deceased subject to this immunosuppressed recipient.
Although you included this subject?s medical history in the INDs submitted to FDA in [redacted], we note that you failed to report to FDA that this subject received cells activated with an allogeneic tumor extract.
9. During the inspection you stated that you have never seen the laboratory (ies) where the investigational activated cell product has been manufactured since [redacted]. You stated that you have no records to document how the investigational activated cell product was/is manufactured, or that quality control testing was/is performed.
In the INDs you identified several steps in the manufacture of the investigational activated cell product, yet you cannot document that the product was adequately or consistently manufactured, and that the investigational activated cells were viable and sterile at the time of injection.
In addition to the serious deficiencies associated with the investigational new drug studies you conducted, there were deficiencies associated with your conduct of an investigational device study entitled, [redacted]. The Investigational Plan for the Pivotal Trial of the [redacted]. Study Indication: The study was sponsored by [redacted] to investigate the device [redacted], in support of the investigational device exemption (IDE) application [redacted]. You failed to adhere to the specific responsibilities of investigators in that you did not have IRB approval between [redacted] yet you continued to conduct research activities associated with the [redacted]. You failed to maintain study subject source documents relating to the investigation and complete [redacted] records relating to your participation in an Investigation. You failed to conduct the investigation in accordance with the investigational plan. For example, the study protocol for the [redacted] study requires placement of heparin (1-2 ml) into the sterile bowl containing the bone marrow aspirate to prevent the bone marrow aspirate from clotting. This procedure was not performed for some study subjects.
This letter is not intended to be an all-inclusive list of deficiencies with your clinical study of investigational drugs. It is your responsibility to ensure adherence to each requirement of the law and relevant regulations.
Please notify us, in writing, within fifteen (15) business days after receipt of this letter, of the steps you have taken or will take to correct the noted violations. If corrective actions cannot be completed within fifteen (15) business days, state the reason for the delay and the time within which the corrections will be completed. This letter does not preclude the possibility of a corollary judicial proceeding or administrative action concerning these violations.
Failure to achieve correction may result in enforcement action without further notice. The actions could include termination of your IND, initiation of disqualification proceedings which may render a clinical investigator ineligible to receive investigational new drugs and devices, and/or injunction.
Please send your written response to:
Patricia Holobaugh (HFM-664)
Division of Inspections and Surveillance
Food and Drug Administration
1401 Rockville Pike
Rockville, MD 29852-1448
Telephone: (301) 827-6221
Viola Sellman (HFZ-312)
Chief, Program
Enforcement Branch II
Office of Compliance
Center for Devices and Radiological Health
2098 Gaither Road
Rockville, MD 20850
(301) 594-4723 ext. 127
We request that you send a copy of your response to the following Food and Drug Administration offices:
Carl E. Draper, District Director
Food and Drug Administration
6600 Plaza Drive, Suite 400
New Orleans, Louisiana 70127
Howard E. Lewis
Branch Director
Food and Drug Administration
297 Plus Park Boulevard,
Suite 100
Nashville, Tennessee 37217
Sincerely yours,
Charua konnon for Larry D. Spears
Director Office of Compliance Center for Devices and Radiological Health
Steven A. Masiello
Office of Compliance and Biologics Quality Office of Compliance
Center for Biologics Evaluation and Research
Center for Devices and Radiological Health


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5 Stocks Setting Up to Break Out
NEW YORK ( TheStreet) -- Trading stocks that trigger major breakouts can lead to massive profits. Once a stock trends to a new high, or takes out a prior overhead resistance point, then it's free to find new buyers and momentum players that can ultimately push the stock significantly higher.
A perfect example of a successful breakout recently was Digital Generation (DGIT). Last Wednesday, I noticed that this stock was trending up strong with above average volume. In my 4 stocks under $10 making big moves article, I flagged the stock for its strong action and highlighted the key price points that would trigger a near-term breakout trade.
>>Also see: 7 Stocks Ripping Higher on Spiked Volume
Guess what happened? Shares of Digital Generation triggered that breakout five days later once the stock took out some near-term overhead resistance at around $10 a share. The stock subsequently skyrocketed to high of $13.20 a share. That's a 30% return in just a few days, all because the stock broke out with heavy volume.>>ACTIVE STOCK TRADERS: Check out Stockpickr's special offer for Real Money, headlined by Jim Cramer, now! Trading breakouts is not a new game on Wall Street. This strategy has been mastered by legendary traders such as William O'Neal, Stan Weinstein and Nicolas Darvas. These pros know that once a stock starts to break out above past resistance levels, and hold above those breakout prices, then it can easily trend significantly higher. With that in mind, here's a look at five stocks that are setting up to break out and trade higher from current levels.
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subset: commoncrawl


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AppDirect is becoming the recognized leader in cloud marketplace infrastructure and there is no other platform that can offer their range of advanced features and functionalities.
We wanted a partner we believed would listen to us, work with us, and be as fast as we wanted to be, and that's what AppDirect delivers.
AppDirect has an out-of-the-box solution that we could use right away to build our solution. Now we're able to provide a much more seamless experience for our customers.
We have been able to leverage AppDirect's marketplace expertise and responsiveness to get to market quickly with high-quality results in a way we would have never been able to accomplish on our own.
New Relic and AppDirect share a common vision and passion for helping organizations acquire the tools and skills they need to deliver superior online service.


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Our regular classes are canceled in observance of Memorial Day. We will be honoring a fallen hero at 9 am by doing the workout "Murph."
In memory of Navy Lieutenant Michael Murphy, 29, of Patchogue, N.Y., who was killed in Afghanistan June 28th, 2005.
This workout was one of Mike's favorites and he'd named it 'Body Armor.' From here on it will be referred to as 'Murph' in honor of the focused warrior and great American who wanted nothing more in life than to serve this great country and the beautiful people who make it what it is.
Workout of the Day
1 mile Run
100 Pull-ups
200 Push-ups
300 Squats
1 mile Run
For time.
Partition the pull-ups, push-ups, and squats as needed. Start and finish with a mile run. If you've got a twenty pound vest or body
armor, wear it.


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|Complete Jewish Bible (CJB)
|New International Version (NIV)
|5 You will summon a nation you do not know, and a nation that doesn't know you will run to you, for the sake of ADONAI your God, the Holy One of Isra'el, who will glorify you."
|5 Surely you will summon nations you know not, and nations that do not know you will hasten to you, because of the LORD your God, the Holy One of Israel, for he has endowed you with splendor."
|Complete Jewish Bible Copyright 1998 by David H. Stern. Published by Jewish New Testament Publications, Inc. All rights reserved. Used by permission. (The Complete Jewish Bible Online)
|Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online)


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Beautiful paper trims from Germany are a lovely matte orange, perfect for Autumn inspired projects.
The detail in these will have you reaching for them over and over again for your special creations.
These are long strips & will be gently folded in the center for ease of shipping.
21" in length
Please note measurements on all items. Some items may appear
larger or smaller than they actually are due to magnification to show detail & color.


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Silent Hill
Community Activity
CommentAdd a Comment
It is a great movie and it is scary because it implants scary images in your head.
It was O.K for a home TV movie. I was entertained and interesting. But it was NOT worth the long library wait or the price to rent from a Red Box. I fast forwarded a lot but not all the way.
The movie brought back memories of the Silent Hill game. The game was great but the movie was not. I almost fell asleep watching it.
If you are a Silent Hill gamer you will get the gist of the timeline of the movie (I read the Wikipedia page) if not the story is inevitable will confuse you. It's a continuation of the first move they took the other parts of one they left out of the first one and gave it to you here. Well it's effective creepiness are quite bothersome and there are some scenes that will leave you queasy. The story is lost in gore and flash, the actors are all comatose, from trying to deliver a dead plot (no pun intended) nothing is thoroughly explained unless (again) you have played the game.
i think the first one is better. This one didn't really get me inti it.
All I can say is, "Whaaaaat?"
High expectation, low delivery. Spookiest game ever made, decent first movie, but average sequel in the horror genre. They did not get my money however, I took it out from the Brooklyn Library so it was worth the price.
I remember being so elated that there was going to be a movie made of the Silent Hill games and I thought the first one was absolutely incredible. Of course it had special effects, but much of the set and even the monsters were all modeled by hand. The movie was artistic, beautiful, and the acting was fantastic. Unfortunately, this one was nowhere near as good. the acting was very campy, the effects were somewhere in the middle, and they did a less than stellar job of explaining the story line. The only reason I knew what was going was because I played through all the games and the idea of Silent Hill makes better sense to me because of it. This being said, I was still able to watch the whole thing and it wasn't *horrible*. Just disappointing.
The effects in this movie were top notch. The creature effects and the settings were creepy and just dripped Silent Hill. The story was all over the place and the acting was ho hum. Looked great. That is the draw here. Don't expect to be scared, but I was entertained.
I agree, it was highly confusing and i became alittle lost and yet, the sense of the movie: the chills feel very terrifying, something I like in my horror flicks, the least it can give to many viewers and S.H fans. This movie totally deserves 4 1/2 stars. Bravo, Open Road pictures!
NoticesAdd a Notice
Frightening or Intense Scenes: Scenes of dismemberment and disembowelment.
Sexual Content: Some scenes do have sexual connotations and breasts are shown.
Violence: Extreme scenes of fighting and bloodshed, people being decapitated or used for torture.
Coarse Language: About 3 F-words and its derivatives, 2 scatological terms, 3 anatomical references (butt, behind, ass), 3 mild obscenities and 5 religious exclamations.
AgeAdd Age Suitability
PrimaGigi thinks this title is suitable for 17 years and over
theresaannalee thinks this title is suitable for 18 years and over
brooklynlibrary79 thinks this title is suitable for All Ages
QuotesAdd a Quote
"Darkness cannot drive out darkness, only light can do that. Hate cannot drive out hate: only love can do that." ― Martin Luther King, Jr
Heather Mason: You created this nightmare...
Alessa: Everyone has a different nightmare in Silent Hill, I am theirs.
SummaryAdd a Summary
When her father disappears, Heather Mason is drawn into a strange and terrifying alternate reality that holds answers to the horrific nightmares that have plagued her since childhood.


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Oakbrook Terrace Family Law Attorney
Sherby D. Scurto believes it is still possible for parents to retain their relationships with their children even after a divorce. This is why Ms. Scurto focuses so much of her energy as a DuPage County divorce lawyer on keeping parents involved in their children's lives, and helping divorcing parents maintain a mindset of cooperation and collaboration.
Dedicated DuPage County Family Law Attorney
The Law Office of Sherby Dianne Scurto, P.C. handles all aspects of Illinois family law cases, including: Divorce, Military divorce, Division of assets and debt, Paternity, Child custody and visitation, Child support, Adoption, Post-decree modification, Spousal support, Removal and Relocation.
Consider your divorce options.
A courtroom battle, in my opinion, is not helpful for anyone. The children suffer watching their parents portray each other negatively before the court. The parents cause unnecessary pain to each other and hinder their ability to co-parent after the divorce is finalized. My goal is to get all divorce issues settled before trial so you can get on with your life.
Your online Illinois divorce resource center.
Divorce is never easy. It is an emotionally straining process layered with complicated legal decisions that may permanently affect you and your loved ones. Most people have very little knowledge on the specifics of divorce - the financial aspects and their legal options. We hope the resources we provide will help you through your divorce process.
Sherby D. Scurto has been selected by Super Lawyers of Illinois as a 2010 and 2012 Rising Star, an honor given to only 2.5 percent of all Illinois attorneys who have been practicing 10 years or less. If you have a family legal dispute contact Ms. Scurto, a DuPage County divorce attorney, online or call 630-873-3559 for a free consultation to discuss your case.


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Gift Guide: 10 games to make any player happy
A video game store can be daunting if you don't know what you're looking for. It's not easy to tell the winners from the losers, and sales clerks typically make the same salary whether they sell you a gem or a stinker. ('Farming Simulator,' anyone?)
So when you head to the mall, take this list. These are some of the best games of 2013, and any gamer on your holiday shopping list will be thrilled to see one of them under the tree.
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This video game image released by Ubisoft shows a scene from "Assassin's Creed IV: Black Flag." (Ubisoft, for the PS4, PS3, Xbox One, Xbox 360, PC, $59.99): Jack Sparrow's got nothing on Edward Kenway, the swashbuckling hero of this pirate romp. There are treasures buried everywhere in this version of the 18th century New World, but the real prize is the rousing ship-to-ship combat across a churning Caribbean.
Photo by Ubisoft
Photo by Ubisoft
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In the community


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Socks by Sock Dreams
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Chocolate Knee Highs
Restocked! We get these CHOCOLATE socks made just for us and we only do it once or twice a year so get yours while you can! A most delicious sock, in milk chocolate brown with silver sparkled letters. Made in the USA.
Fits women's US shoe size 7 - 13 and men's US shoe size 5 - 11, though we found they do fit even women's size 6 feet pretty nicely!
14 inches from heel to top of cuff unstretched.
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~ Katie J.


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Friday, December 19, 2014
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Fans heading to the SU-Georgetown basketball game Saturday can help combat hunger throughtout the region. The Food Bank of Central New York is asking fans to bring non-perishable food items to the game. Our Brad Vivacqua is outside the Carrier Dome and joins us now with more on the Can It Initiative.
Fans heading to the SU-Georgetown basketball game Saturday can help combat hunger throughout the region.
The Food Bank of Central New York is asking fans to bring non-perishable food items to the game.
"Can It!" is a university-wide interfaith initiative, and several students on campus will be helping to collect the donations.
Items needed include canned vegetables, fruits, and tuna fish, peanut butter, soups, rice and cereal. While these are suggestions, the Food Bank is appreciative of any donation.
CNY Food Bank Philanthropy Director Lynn Hy said, "We are in 11 counties in Central and Northern New York, and there's a lot of need out there. So, having large scale donations like this, it really helps us so that we're able to continue our mission and get nutritious food in the community."
Last year, the "Can It!" initiative helped collect more than 1,300 pounds of food at the SU-Georgetown game. The goal is to surpass that this year.
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Bones Review: Icing on the Cakeby Carissa Pavlica at . Updated at . Comments
A celebration of Christine's first birthday should have been sweet, but instead Bones Season 9 Episode 18 fell flat on just about every level.
Sometimes nothing in an episode really seems to fit and this was one of those times. Brennan's inability to process the importance of her child's first birthday was just icing on the cake.
The case of the week was rather irritating in how it combined the children's show with a woman's obsession for a man dressed in a carrot costume. In conjunction with Christine's birthday, it felt dirty to be associated with the timing of the case.
UPDATE: When this review originally posted, I was thinking this was Christine's 1st birthday party, instead of her first birthday PARTY. Have you ever had a moment when your reading comprehension throws you off and you're certain everything you just read was true? I fell under a spell and Lilian pointed out in the comments what a grievous error I had made. So, thank you!
Carrying on, It may seem as though I'm picking on Brennan, but Booth didn't really have an excellent idea for the party either. I'm with Brennan on this one.
Booth: Show one person who doesn't like a one man band.
Brennan: I'm sure many don't like them which is why they're such a rarity.
A one man band is about as exciting as a clown. My expectation was for Booth to show up in the instruments and for the kids to run away in fear. Maybe they would have had they actually been one year olds like I originally thought!.
It's easy to cut Brennan some slack because she has an interesting mind, but not having done any research on birthdays or children just because she herself didn't have parties growing up seems counter intuitive to her intelligence. She's inquisitive by nature so why is she always so uninformed when it comes to the everyday mundane things that should interest her because of her new life?
She's also very much beyond opening up her mouth to speak as she did to the carrot's brother when she told informed him his brother was dead and corn is not a vegetable. The inconsistencies in her character in episodes such as this one as compared to what she felt when she worked with the professor in Bones Season 9 episode 11 after his daughter died.
Brennan's growth needs to be more consistent and not a necessary plot device when it feels like it might be humorous. By this point and after 9 years of working with emotionally stable and respectable people who have helped her see through their eyes how to treat others, a backward slide isn't cute.
The woman who startled Joe the carrot (who then died) and made the horrible decision to ditch his dead body because she didn't want people to think she was responsible for his death was also a sticking point for me because Brennan said she was responsible for his death. Was she really? Sure, she kind of stalked him and honked her horn but he stopped taking medication that kept him alive.
What the woman was responsible for was creating a cover-up for his accidental death. She didn't kill him outright and it wasn't nice of Brennan to make it appear as if she was.
Finally, Clark writing a novel that contained some absolutely horrible writing in it only to find out it was published before his friends had to give him the bad news that it was truly awful was another unfunny storyline. I'm not exactly sure what the point of it was. I sincerely hope books submitted with writing that atrocious aren't often rewarded with publishing deals.
So what did you all think? Was I just in the wrong frame of mind? Was this a fun installment of Bones that celebrated Christine's life in a meaningful fashion? You can relive all of Christine's early years when you watch Bones online. Then have at it in the comments.
Did you enjoy Christine's birthday party?
Carissa Pavlica is the managing editor and staff writer for TV Fanatic. Follow her on Twitter and on Google+.Tags: Bones, Reviews
Sunnie is adorable, but was this really Christine's first birthday party? Or was there some lapse in time I wasn't aware of? Because she looks more like a three or four year old, definitely not a one year old.
If I were as young as Christine, the one-man band probably would have scared the crap out of me! I once read an interesting article about Asperger's syndrome (a high-functioning autism)...it said that, while the show isn't saying one way or another, that her behavior and social skills are what it would look like. Same with Zach and with Sheldon from "Big Bang Theory". Again, that's not saying they *do* have it, but that's what someone on that spectrum would look like. That would explain a *lot*. And yes, she still is blunt about telling people their friend is dead, but I'm not sure there's any good way *to* say something like that.
I didn't love the episode either. I totally agree with your point about Brennan's character inconsistencies. She had far more sensitivity in her tone of voice in the S1 pilot even if she was delivering the news with clinical terms and jargon. Brennan used to care so much about the victims and their families. She had so much depth as a character. She cared about people, she was just trying so hard not to show it. But now that she has allowed herself to trust in emotions, we should be seeing her emotional and empathetic side far more consistently. But what I see in stead is a flanderizing effect. Now they have intermittently reduced her to a cartoon character. I am starting to lose interest. I don't mind light and funny episodes but Brennan has never been shown to be that callous about delivering death news to a victim's family. I understood where she was coming from in terms of bdays though. As Sweets said she was trying to justify what happened to her by downplaying the significance of bdays which is a very human response. What struck me more was how much Booth was overcompensating for his insecurities to be a good father. He didn't want to pay attention to Sweet's suggestion to let Brennan help him plan the party because in the car scene he just told her to let him handle it. He was obsessed with doing something spectacular but that doesn't make a child feel anymore special than just getting attention from their parents. Even though he got bday parties as a kid and Brennan didn't, Brennan had the better father. Christine enjoyed a game of tag a lot more than she enjoyed the one man band. I wish sometimes they focussed on Booth learning that what he thinks is important is actually not. Superficial things like bouncy castles or one man bands aren't really important. Booth didn't want to disappoint Christine but she didn't even care about the one man band.
I have always been a loyal Bones fan. But I'll be honest, I miss the Brennan we had in earlier seasons (1-4). I feel like they are trying so hard to use her character as comic relief now, that the emotional growth she had shown is all but gone.(Even though the show runners somehow believe she is growing) I had hoped that once her character had a child, we would see more of an evolution. But even in this most recent episode, her crass remarks and lack of tact not only made me cringe, but I see more eye rolling and frustrated looks coming from Booth. As it is, I don't see what he sees in her now. You saw them grow together in earlier seasons and have those intimate revealing moments together, and now she just spouts so much mumbo jumbo in such a rigid way that I don't see anything that really establishes that they really love each other. No flirting at the diner, no subtle touches or even lingering eye contact. There used to be a look of desire in Booth's eyes when he was with Brennan. It was subtle, but profound. Now I feel like they tied the romance up with a wedding and are done nurturing it….I really hope they can re-establish it and bring back the more emotional and sensitive Brennan. The one that they all but forgot helped the homeless man, gained the trust and related to foster kids, built a bridge to help baby Andy's town, wanted to save poor Ripley and who responded in kind to Booth's Japanese friend with the missing sister.
Bones doesn't understand the basics of her new life because she thinks such "irrational" things are worthless or not worth looking into when there's science to be done. She's grown a lot since the first season but I still see that sometimes.
while i agree about the inconsistencies in brennan's character, I'll let it pass coz such things happen when you get new writers.not that thats an excuse...i did come up with an explanation for her blunt and matter of fact comments in this episode. while she normally makes an effort to be more sensitive, she is a naturally blunt person. here she wasnt really making an effort to be nice probably coz her mind was on christine's party and so whatever she said was perhaps coming out uncensored. i loved the party...im happy abt hw brennan handled clarks new book coming out. also happy abt wat finally happnd in that storyline, getting published despite being rubbish...so many rubbish books are published...i do hav a problem with one thing- this review...TV fanatic always gives Bones overly negative reviews. it wasnt the greatest episode, but it wasnt bad either, no where near as bad as you make it out to be...youve done this before as well, giving other Bones episodes negative reviews which were undeserved. and I hav pointed it out before as well. I suggest you ease up on the show...and if you hav something personal against it, please stop reviewing its episodes
All of your abbreviations make your sentences difficult to intrpret and render what could potentially have been an intelligent comment totally unreadable.
No offense, Lisa, but you obviously haven't been reading the reviews since I started covering the show in January. This is the first episode that didn't receive about 4 stars or above. I've consistently given it good reviews and the last episode received a lower rating by readers than I gave it. I don't mind generalization, because we all do it, but individuals write these posts and I don't think your comment fits how I've been covering the series.
As much as I hate to agree with you because I generally love this show, you're absolutely right. I have been particularly annoyed with Bone's inconsistent growth. You are correct-she's highly intelligent and she's been at this 9 years, she's beyond these foolish interpersonal mistakes. It was funny in the beginning but now it's just out of character. Also, there was no heart in this ep. I felt no connection among the characters.
What I don't like is that I am cheering for Brennan in one ep and then so disappointed the next, which makes me wonder if people don't share their notes about the character. I don't believe the Brennan I've been watching this season would have reacted as such. She did last week with the new intern because she felt threatened. In that situation it made sense. I have no doubt it will be better next week, but I can't artificially grade a lower ep high just for that. Thanks for reading!! :-)
I too felt that the "Crime of the Week" was a bit banal, but did enjoy the quibbling between Christine's parents as to what kind, if any, birthday party their daughter should have. Booth has given Brennan "family roots" that were lacking in her childhood, for whatever reasons. Max's excuse was weak, given that he was a science teacher, and obviously living a somewhat public life. What harm would a birthday party have triggered? I did like that his recollection to Brennan about how much she loved to play tag as a child, was the impetus for her to open up to the idea of her daughter's birthday party, and I found the closing scene, with little Christine egging her parents into a game of tag endearing. We have all seen series that age young characters, sometimes too much, but the slight adjustment to what many of us consider Christine's chronological age, is acceptable, given that fact that now they want some active participation from the child actor portraying her, and the twins who shared the role previously are not at that coachable age. Plus we recall that there were some issues with their shared participation in the wedding episode, because the large assembly of actors and extras startled them. To that point all scenes with little Christine have been more "one-on-one" or rather, parents and child. The twins who portrayed Christine to this point were adorable, and the new young actor seems well prepared, with a bit more seasoning. I look forward to seeing more of her in future episodes.
hi Linda, please correct me if i'm wrong but i thought that the twins are still playing Christine...In this episode, wasnt Christine played by Ali Hartman, the older twin.i know she looks different coz we havnt seen the twins in a long time, n also her hair is different n longer, but from the shape of her face n her smile, I concluded she was Ali. if u know otherwise, pls let me know the name of the new actress playing Christine
The actress playing Christine was Sunnie Pelant. There is a photo of her with Emily Deschanel in front of the swings on her IMDB page.
Pelant? Really???
It was Christine's first birthday PARTY not first birthday.
Well thank you Lilian. THAT clears it up. Please accept my gratitude and see your name up above!
wasn't the best episode for me. i too couldn't see why clarks book was going to be published when it didn't sound good at all. i was glad to see max again. some of the episode was good but some of it was flat. the tag at end was cute but maybe just me but christine seems to be growing bigger each time


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Christmas Gifts and The Long Count
CGS: Episode 345 (December 20, 2007)
We open a few Christmas gifts from listeners and then we talk to Jason Blair and Leanne Buckley the creators behind the new series The Long Count from ASP.
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Happy Valentine's Day from Fancy Dress Ball! Comments Off
It's the most romantic day of the year and there are flowers, cards and Cupid's arrows flying about all over the place, so we'd just like to wish all our fancy dress fans a very happy Valentine's Day!
We hope you're all lucky in love today, whether you're spending the day with your long-time love, hoping to spend the evening with your desired love or out on the quest for love with the help of our friend Cupid.
Google is celebrating Valentine's Day with a Doodle dedicated to George Ferris, the creator of the original Ferris wheel. In it, you can launch a fairground love machine that finds the perfect partnership. Play it here!
If you're struggling for inspiration for a romantic poem, fear not, as the Telegraph is playing Cupid for you. Click here for their top 10 romantic poems to tell your darling just how much you love them with meaning.
And, of course, when it comes to that particular room of the house, make sure you don the sexiest costume you have to make it a night to remember…


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Mesa police searching for female car burglar
The suspect, described in a release as a white female with black hair, is believed to have broken into two vehicles on Thursday, July 10. She is also thought to be the driver of a newer white Ford Edge.
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The suspect attempted to cash one of the stolen checks at the TruWest Credit Union located at 5136 East Roosevelt Street in Phoenix.
Police are offering a reward of up to $1000 for information leading to the suspect's arrest. Those with information are urged to call (480)-WITNESS.
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Friday, April 12
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Glenwood Yoga
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