text:
So you want to do a podcast ?
Well you've come to the right place. Our goal here at HPR is to make it as easy as possible for you to get a podcast released. We take care of the hard bits so you don't need to. Recording your first show is always a daunting prospect but over 200 people like yourself have done it and so can you.
Syndication of non HPR Shows
We will continue to promote new podcasts and other creative commons material but due to a lack of slots, we are only releasing material created exclusively for HPR. If there is a piece of creative commons content that you would like to promote, then feel free to record a regular show where you introduce the content and explain why it is important, providing links to where we can get more information.
Stuff you need to know
You are agreeing to license your show CC-BY-SA
All our shows are now released under a Creative Commons Attribution-ShareAlike 3.0 Unported license, which means that while you continue to retain the copyright to your show you are allowing us (and everyone else) to use it provided we give you attribution and that we release it under the same license. Click the link for more information.
You have permission to redistribute your show in its entirety
Never include content, e.g: music, in your show that you do not have permission to redistribute. Try to avoid using any content in your show that can not be redistributed under a Creative Commons Attribution-ShareAlike 3.0 Unported license. If you are redistributing under another Creative Commons License or by arranged permission please make note of the restrictions when you upload your show. We can then signal that so that others who redistribute HPR content can filter your show out.
Your show will not be moderated
We do not vet, edit, moderate or in any way censor any of the content on the network, we trust you to do that. Aside from checking snippets for audio quality/spam checking, we have a policy that we don't listen to the shows before they are aired. This is a long standing tradition arising from the fact that HPR is a community of peers who believe that any host has as much right to submit shows as any other.
Your show will be signalled as containing explicit content
Given that we are an open forum for free speech we signal all our shows as "explicit" with the assumption that the listeners will apply the required discretion when playing the shows in public. The fact is that the majority of our content is technical in nature and therefore is often considered appropriate for any audience. If you feel that your show will be considered inoffensive in every region of the world then you can signal that when you upload the show.
When dealing with content that is "explicit" or contains material that would best be suited for a mature audience, it has become traditional to include a short warning at the very beginning of the show before the intro, to allow listeners time to switch off the episode should they so desire.
You determine when your show will be released
The HPR Schedule is entirely community driven and we recommend that you pick the date or show number as then you know when your show will be released. All shows are scheduled on a strict "first in - first out" basis, but the slots will only be allocated once the shows have been successfully processed. Any missing information can result in a show missing the requested slot. Once the slots have been allocated it is not possible to move them.
Your show will be heard by an International Audience
We have people listening from all over the world, who may not have the same cultural background as yourself, therefore you should be as clear as possible when giving details. For example always give temperatures in both Celsius and Fahrenheit, measurements in Metric and Imperial, dates in YYYY-MM-DD iso8601 format, and abbreviations using the NATO phonetic alphabet. Never assume that your audience knows what age a sixth grader is, or how big a 20 Cent Euro coin is. Keep in mind that keyboard layouts are also different so make sure to specify the key shape or the position in relation to a common known standard. For example:
The at sign normally situated above the 2 key on a US keyboard, and has a unicode number of U+0040. For more information see Wikipedia
The HPR Schedule is entirely community driven and we recommend that you pick the date or show number as then you know when your show will be released. All shows are scheduled on a strict "first in - first out" basis, but the slots will only be allocated once the shows have been successfully processed. Any missing information can result in a show missing the requested slot. Once the slots have been allocated it is not possible to move them.
- Always try and fill any free slots that are available in the upcoming week.
- If the queue is filling up then please consider leaving some slots free for new contributors.
- If you have a non urgent show then find a empty week and schedule it then.
Emergency Queue
The emergency queue is intended only to be used in the cases where there is still a gap in the schedule 24 hours prior to release. The shows will by their very nature need to be "timeless", ie: your topic should still be relevant in four years or more. People will be able to hear the show on the website but they will not be included in any feeds until release.
Please begin all shows with text similar to:
"This is an emergency show, if you are hearing this then HPR needs shows ASAP. Please consider contributing a show. Email admin at hacker public radio dot org for more information."
We expect that we need at least 10 shows in the emergency queue in order to give people enough time to record and submit shows. Remember once that all the emergency shows have been used up and there are no more shows in the queue, HPR as a project will stop.
Show Notes
If you do not supply show notes, they will be created for you but this will result in a delay as a HPR volunteer will need to listen to your show and write them. It is always better if you send us show notes yourself as you know best what information you are trying to convey.
The show notes are important because:
They provide the listeners with more information on the topic
You have taken the time to record a show on a topic, so many people will want to find out more on the subject, therefore you should include links to give more information. It is not enough to just give it in the show itself as people may be listening while away from the Internet, and they may have forgotten or misheard your links.
They ensure your show gets posted on time
Our processing script uses the first lines of the show notes to automatically process the show. If you do not supply show notes then your show will need to be processed manually by an HPR volunteer and this will most likely result in delays. During that time other shows will be processed and may get posted before your show.
They encourage people to download your show
We produce a lot of shows and many people download based on the text in the show notes. If the show notes are not descriptive then it is less likely that it will get as many downloads as other shows with good show notes.
They allow your show to be indexed by search engines
Search engines cannot determine the content of your show from the audio alone. The only way for your show to be indexed is for you to describe in the associated text what you say in the audio.
They make your show accessible to the deaf and hard of hearing
Your audio is completely inaccessible to those who have hearing problems, so the only way for your show to be of help to them is if you distil the essence of the show into the show notes. If you are using a script to prepare your show then include that.
Show Note File Format
We use UTF-8 end to end.
See the video Characters, Symbols and the Unicode Miracle - Computerphile for an interesting background to ASCII and UTF-8
The information at the top of the show notes file tells us how we should process your show. It's always a good idea to download the latest Sample Show notes (html) template file before you upload your show. You will see that the top of the file has the following entries:
Hostname: Email Address: Show Title: Desired Slot: Show Summary Added: Intro and Outro Added: Series: Tags: Explicit: Short Summary: Show Notes: ...
Before we explain what each of these are for, make sure you include the field name unaltered in your show notes, including the colon ":", as we use those strings to parse the file. Remember All information will be displayed publicly. The only exception is that your email address will be sent in the feed with some anti-spam additions.
For example firstname.lastname@example.com will become email@example.com
Also remember that all fields are optional, but if you don't include them then an HPR Volunteer will need to add them manually, which will most likely result in a delay posting your show.
Required and should be the handle you wish to be referred to as on HPR. It can be your real name, an Internet handle or both.
Email Address:
Required and must be a valid email address where we and other listeners, can contact you. We may use this to confirm that you sent the show. You can supply your email unmodified, or with the at-sign replaced with dot nospam at-sign nospam dot.
Either firstname.lastname@example.com or firstname.lastname@example.com will be accepted.
Show Title:
Required This will be a short descriptive title and will be used everywhere to identify your show. Any valid UTF-8 character is acceptable, but keep the length short and clear.
Desired Slot:
Required This tells us when you wish to have your show released. The options are limited to:
- hpr?????
which tells us to release on this free episode number. This is a preferred option.
If you select this option then please replace "????" with numbers, do not send in the string "hpr????"
specified in iso8601 format, which tells us to release on this date, which must be a valid free release date.
If you select this option then please replace YYYY-MM-DD with numbers, do not send in the string "YYYY-MM-DD"
- Next
which tells us to release the show in the next free slot, skipping over reserved shows.
If you select this option then please send in the string "Next"
- Emergency
which tells us that the show is an Emergency Show and will not be scheduled in the queue. See notes above
If you select this option then please send in the string "Emergency"
Valid examples of Desired Slot:
Desired Slot: hpr9876 Desired Slot: 2099-12-31 Desired Slot: Next Desired Slot: Emergency
Show Summary Added:
YES or NO
This tells us whether you added the Show Summary, which is a brief spoken introduction that gives the listener some information about the episode.
eg: It is Thu Dec 31st 2099 and this is HPR episode 9876 entitled "Transforming Heliposis". It is hosted by Zork and is 22 minutes long. The Summary: "Upgrading Heliposis with Ubuntu 2099-04 tenatious targ"
Only add the Summary if you know how to get the levels correct between the segments, otherwise leave them out and our processing script will add them for you.
If you have added it then enter YES, and if you have not added it then enter NO.
Intro and Outro Added:
YES or NO
This tells us whether you added the Intro and Outro clips.
The intro is the slick0 theme and is used on all HPR episodes, while the outro is a HPR inspired theme but contains important information about the HPR project.
Only add the clips if you know how to get the levels correct between the segments, otherwise leave them out and our processing script will add them for you.
If you have added them then enter YES, and if you have not added them then enter NO.
Pick an existing series and copy and paste the name.
Add a list of comma separated tags. Pick the most important words from the shownotes
Specify "Yes", or "Clean" (See iTunes for more information.)
Short Summary:
Recommended This is a short 100 character summary of what your show is about. Please fill this out as it is used once the show has gone off the main page, on the mobile site, on printed brochures, on text to speech announcements, on twitter, facebook, Google+ etc.
Show Notes:
Recommended This is a long 4000 (*) character text detailing what your show is about.
The remainder of the file will be your show notes to be displayed on the site. Please restrict yourself to text unless you are experienced writing html by hand. If so then note that your notes will be in a <article> html5 section, where the header and footer are not available to you, also avoid using <div> or <span>. The inclusion of JavaScript will send your show into quarantine, until an experienced HPR volunteer can be found to debug it.
It takes us a lot longer to fix incorrectly formatted html than formatting plain text, so please only create html show notes if you know what you are doing and are sure that what you are writing is valid xhtml/html5.
Hostname: Jo Blogg email address: email@example.com Show Title: How I got into Linux Desired Slot: Next Intro and Outro Added: Yes Series/Tags: Explicit: Yes Short Summary: Join Jo as she talks of punch cards, BBC Micros, Commodore 64, Windows 95 and Mandriva. Show Notes: The first introduction to computers I had was sorting punch cards during the summer in my fathers workshop etc .... Links: - http://en.wikipedia.org/wiki/Punched_card - http://en.wikipedia.org/wiki/BBC_Micro - http://en.wikipedia.org/wiki/Windows_95 - http://www.mandriva.com/en/ etc ...
Uploading files
FTP Server
Please email admin at hacker public radio to get access to the ftp server
File names
Only use "A-Za-z0-9" "-" or "_" in the file name. Do NOT use spaces, braces "(){}[]", punctuation "' etc. in the file name.
Prefix the files with your hostid, then name or handle, then the date or show number, followed by the show title and then extension. New hosts should use "0" for their first post.
The filename must be the same for all files, change the extension of the audio, shownotes and optionally one image.
999-Zork-hpr9998-Transforming_Heliposis.flac 999-Zork-hpr9998-Transforming_Heliposis.txt 999-Zork-hpr9999-Understanding_Fourier_transforms.flac 999-Zork-hpr9999-Understanding_Fourier_transforms.html 999-Zork-hpr9999-Understanding_Fourier_transforms.zip
Additional material
If you have more files that you wish to include, then include the audio, and shownotes file as normal, and put the rest in a zip, or tgz file. This should expand to a directory with a index.html file that refers to the other files. This will be hosted in http://hackerpublicradio/eps/hpr${show number}. Adding additional files will delay processing as they need to be verified manually.
Media Metadata ID3/Vorbis CommentsUse any utf8 characters you like but the format of the tags should be:
TITLE {Your show title} ALBUM Hacker Public Radio ARTIST {Your name/handle} GENRE Podcast COMMENT http://hackerpublicradio.org {Then the short summary}
Bedding/background music
You may include backing music but it's best if you don't. Most long time podcast listeners speed up their shows, as this allows them to cram more shows into a day. Others will convert shows to mono to listen in one ear leaving the other free to carry out their other chores. Still more slow the shows down so that they can improve their English. Others are hard of hearing and backing music makes it difficult to understand the text.
We will by default mix down your show to one channel mono and we will transcode to MP3, ogg and spx formats. If you want to control this in more detail then please email admin at hacker public radio for more information.
You want to record a show but have no idea how to.
The quickest way to get started is to use our call in numbers to record a show over the phone. Simply call:
- Pick up a telephone and dial:
- Listen to the introduction
- Talks to us, and include your name and email address
- Press the # when you are finished and hang up.
That's it. Your show will be automatically sent to us and we will take care of the rest. If you want to send us an email to admin here at hackerpublicradio.org with some shownotes that would be great but it's entirely optional.
Don't forget to end by pressing the # sign. If you don't your show will be lost and that makes us sad.
(Thanks to K5tux for supplying the service and finux for the UK number)
Recording with a portable media player
Many of today's portable media players support recording audio out of the box. Search for "Voice Recorder", to see if there is an application for your smartphone. Whichever option you have close to hand, try and set the recording to the best quality format (WAV or FLAC), and set everything else to the highest setting. It's always the goal to get the best quality audio but here at Hacker Public Radio we value content over quality and so long as it's audible we'll take it.
Then just record your show and attach it to an email addressed to firstname.lastname@example.com and we'll do the rest.
Recording/Editing using your Computer
The majority of podcasters use Audacity.
Audacity is a free, easy-to-use and multilingual audio editor and recorder for Windows, Mac OS X, GNU/Linux and other operating systems..
First open the Intro Clip as this will have all the correct settings applied (Project Rate of 44100Hz).
Next you can either record your show in Audacity itself or import the file you recorded earlier and edit it as you wish.
Finally use File -> Import to import the Outro Clip. You will need to line all the tracks up using the time shift tool.
When you have finished editing your podcast you can export it.
- Confirm that the Project Rate is set to 44100 Hz (bottom left)
- File -> Export and select FLAC File
- Click Options... to reveal FLAC Export Setup
- Set Level to 8 (best)
- Set Bit depth to 24
We mix down to mono by default so if you want stereo then make note of it in the shownotes.
When you are ready you can contact email@example.com to get access to the FTP server.
Recording Interviews with the Phone
If you want to record a one-to-one interview with someone then you can use Skype in conjunction with Skype Call Recorder. If everyone is using skype then it won't cost you anything otherwise you will need to pay for SkypeOut service.
Recording round table discussions
If you would like to record with multiple participants then you can use Mumble. Connect to ch1.teamspeak.cc Port: 64747 .
Walk through the audio wizard and the pop into the Hacker Public Radio room. Once you are ready press the recording button, select multichannel and then start. That will record multiple tracks, one for each participant which you can edit and then submit.
Kwisher made a Mumble tutorial which you might find useful and Delwin has produced a number of short shows on the configuring audio quality.
Questions ?
Whether you want to do one show, or you have other plans, just email "admin" at "hackerpublicradio.org", and we'll get in touch with you with all you need to know about getting your show published.
You can chat with other podcasters using IRC in the #oggcastplanet channel on the freenode.net network. Follow us on identi.ca (use the tag !hpr) and on Twitter (use the tag #hpr). We have a Facebook and LinkedIn group, so please join and spread the word.
Requested topics
If you would like to record a show on one of these topics, please email "admin" at "hackerpublicradio.org", and we will take it from the list.
- How did you get into podcasting/linux/geekdom?
- What podcasts you listen to and can recommend
- What's in your bag? Tell us what tools/gear/stuff you keep close at hand.
- What got you into Linux?
- Your favorite Android applications.
- Your favorite desktop applications.
- Your favorite browser extensions.
- A introduction to Wireshark.
- How to set up your own blog.
- Choosing a artistic design for website, business cards etc.
- Music Theory
- Installing a VPN to your home network
- Init and System.d
- Episodes for the LPI, or the Networking series.
- Beginning Audio Series for HPR and OSMP Release
- Hackintosh computers - what are they, why would you want one.
- Grub 2.0 introduction and customization.
- FM Transmitter hack to listen into internet streams
- How I Got Into Accessible Computing
- How to do knitting
- How to build a house
- Bitcoin howto hpr0788
- How to solder hpr1037, hpr1047
- How to weld
- How to fix a car
- Reviews of stream playing software, (for linuxheads who don't want to keep a browser tab open all the time)
- Reviews of stream ripping software on linux
- Beginners guide to gnuplot
- Nagios series, intro, setup, advanced ...
- How to set up GPG/openPGP
- What I do with my Raspberry Pi
- It broke, I fixed it
- How does coreboot work
- Introduction to HAM Radio
- I've moved and they do it like this here
- How to record a tag team tutorial on a topic
- Open Street Map new editor
- etymology
- functional versus procedural programming
- sed, awk and grep
- Setting up imap/smtp (gmail) in a cli mail program
- Irssi - a sane setup
- Your view of the future
- Alternative uses for Bayesian email classifiers (more info)
- How to use a multimeter, and other basic electronic components like a 555 timer
- How does Hubble remain fixed on a spot in space while in orbit of the earth
Still Nervous
Fellow listeners like yourself contribute the shows and so we know how hard it is to do that first show. You're probably worried that we won't like the topic -well don't be, have a look at our archive to see how diverse the contributions have been. You're probably worried about the quality of your audio, that you sound funny, that English isn't your native language, that you suffer from a speech impediment, that your show has loads of ummms and awws in it, well don't. Well we have seen it all and at the end of the day the show is about the content and not the quality of the audio. That's not to say we won't help you with ways to help you improve the audio if you wish, or narrate your script if you can't or won't record it yourself. Drop into the IRC channel #oggcastplanet where there are people who will help.
Our Motto
A barely audible show is better than no show at all.If you have any questions about audio quality, then drop into the #oggcastplanet channel on freenode and talk(ok type) to a live person 24/7.


text:
Reviewed by 3 customers
Sort by
- Consistent flavor
- Copious Smoke
- Easy And Smooth Draw
- Nicely constructed
- Remains Lit
- Superb Ash
- Tastes Like Angels
- Very Even Burn
- Must Be Paid For
Best Uses
- great gift
- Poker Of Course
- When you have the time
- With A Special Friend
Comments about Alec Bradley Retreat Double Corona Rosado:
Okay, "perfect" is the penultimate comment, yet it was the only thought going through my mind. I kept raising in to smoke more until I realized I was making it too hot. I smoked it last night in my cabin on Lk Superior (cold already!) and the waves were crashing as befits November on this lake. Today, I am on this site to tell you other cigar burners like myself to try this cigar.
Most cigars I light are harsh initially and settle into whatever they are to become after a minute or three. This A/B starts out great and gets better. I bought it in a sampler and hope very much it stays consistent as I order more.
I see by the site comments it is considered more of a full bodied cigar, yet I would rate it as a medium. I am a faithful Arturo Fuente fan and my humidor has lots of Hemingways waiting for me. I will be ordering ten more to see if this first one I had was a fluke. If not, a box is assured. I will send another review after I check the 10 cigar selection next to see if they remain, um, "perfect".
- Was this a gift?:
- No
Best Uses
Comments about Alec Bradley Retreat Double Corona Rosado:
The perfect cigar.
- Was this a gift?:
- No
Comments about Alec Bradley Retreat Double Corona Rosado:
Love this whether I'm fishing or watching a game or just hanging with the boys.

subset: commoncrawl


text:
Would you like to start a free subscription?
Remember me | Forgot password
For full content view: Log in Now!
Last year saw good drilling levels, at least that's what the numbers indicated. However, despite the fact that global rig activity rose nearly 13% in 2003, the general industry attitude for much of the year was like the half-empty glass. Operators were enjoying high oil and gas prices, but seemed to be anticipating something bad. We were no exception. Based on industry's mind-set and tepid results of our midyear survey of operators' drilling plans, World Oil lowered its forecast for 2003 in August.
This year will be better, since oil and gas prices are holding at high levels, even after things settled down in Venezuela and Iraq. Further, there is good reason to believe that Iraq will not become a significant player in 2003. As we predicted a year ago, oil inventories in the developed countries remained low throughout 2003, staying near the previous five-year average minimum level. The US Energy Information Agency predicts that stocks will linger near this minimum through 2005. Recent US demand gains, plus growth from China and other non-OECD countries, should keep the demand curve moving upward. However, there is a possibility that should energy prices get too high, they could thwart the "jobless recovery" in the US economy. Although OPEC continues to hold the trump card for supply, if operators are not yet convinced that oil and gas prices are truly demand-related rather than emotionally driven, they likely never will be.
This area of the site is restricted.
In order to gain access, please either Log
In, or subscribe to World Oil.
Two options are available to you for creating an account.
1. Get a Free Trial Subscription to World Oil Magazine and gain immediate access to select content on World Oil Online.
Start a Free Trial Subscription and gain immediate access to the complete current issue of World Oil Magazine. Plus, you'll receive 3 upcoming issues of World Oil Magazine in print or digital format.* You also receive access to the Energy Events Calendar, Industry Statistics and WO Wire's news and industry coverage.
Free Trial
2. Purchase a subscription to World Oil magazine and gain immediate
and complete access to World Oil Online. As a Total Access subscriber
you will have access to all areas of the site available to registered users and
free subscribers as well as having access to such premium content areas as:
Physical copies of this content may be available for purchase. Visit the Reprints & Back Issues section.
If you are already a paid subscriber and do not have access, please email firstname.lastname@example.com.
World Oil's specialized upstream Engineering Data Tables featuring the Drill Bit Classifier, Tubing Tables and more. Get Total Access today.
New Delhi - January 11-14
Muscat - January 26-29
Bogota - January 28-29
Please read our Terms & Conditions, Cookies Policy, and Privacy Policy before using the site.
All material subject to strictly enforced copyright laws.
© 2014 World Oil. © 2014 Gulf Publishing Company.


text:
- Home
- About ASF
- What is Autism?
- How Common is Autism?
- Early Signs of Autism
- Autism Diagnosis
- Following a Diagnosis
- Treatment Options
- Beware of Non Evidence-Based Treatments
- Autism and Vaccines
- Autism Science
- Autism Research Strategic Plan
- Research by Topic
- Research by Year
- Interviews with Scientists
- Science Journals
- Autism In The News
- Recommended Reading
- Participate in Research
- NIH ACE Grants
- NIMH Resources
- Autism Research Glossary
- Quick Facts About Autism
- What We Fund
- Funding Calendar
- ASF Funded Research
- Research Results
- Grant Outcomes Reports
- Apply for a Research Grant
- Apply for a Research Mini-Grant
- Apply for an Undergraduate Summer Research Grant
- Apply for IMFAR Travel Grant
- Get Involved
- Resources
- Day of Learning & Evening of Celebration
- Contact Us
Biobehavioral Markers of Anxiety in Autism Spectrum Disorder
Aug 1 2012
Aug 1 2014
America/New York
Location:Center for Autism Research at the Children's Hospital of Philadelphia, Philadelphia, PA
Brief Description:
Individuals with autism spectrum disorders (ASDs) have problems with social relationships and communication. Some individuals with ASDs also have other problems, such as anxiety, that may or may not be related to ASD. Our research is trying to understand why some individuals with ASD also have other co-occurring problems. This knowledge may help researchers develop targeted treatments for ASD and co-occurring problems.
This research study needs individuals between the ages of 7 and 17. Children with ASD are needed to take part; children who do not have ASD and are developing typically are also needed. Participants may not have metal in the body (for example, braces). Participants may not be taking an atypical antipsychotic medication (for example, Risperidone, Quetiapine, or Aripiprazole).
Individuals who take part will receive detailed evaluations and reports. There is no cost to participate and insurance will not be billed. Families will be paid for their time and reimbursed for travel costs.
Eligibility for Study Participation:
Participants cannot:
- Be younger than 7 or older than 17 years 10 months
- Have metal in the body (for example, braces)
- Currently be taking an atypical antipsychotic medication (for example, Risperidone, Quetiapine, or Aripiprazole)
- Have known genetic syndromes (e.g., Fragile X, Down Syndrome)
- Have significant hearing or vision problems
- Be nonverbal or use single words
- Have significant brain injury, e.g., stroke, brain bleeding, brain tumor, hydrocephalus
- Have been born premature, born before 32 weeks
- Have been adopted after 3 months (unless adoptive parents have records regarding birth history and early development)
Participation Details:
Families will need to come to The Children's Hospital of Philadelphia in Philadelphia or in King of Prussia. Study visits will take place in 2-4 visits, depending on what is most convenient for the family taking part.
Children taking part in the research study will receive social, behavioral, intelligence (IQ), and other developmental testing. Children will also have brain imaging and will be asked to give small samples of blood or saliva. Lastly, children will be asked to complete computer tasks while we record basic responses including eye gaze patterns, heart rate, perspiration rate, and breathing. Parents will be asked to answer questions over the phone, in person, and on paper.
Principal Investigator:
Dr. John Herrington
Contact Information:
Julianne Fretz, 1-866-570-6524 or firstname.lastname@example.com
For more information visit:


text:
Smarter Decisions,
Better Care
UpToDate synthesizes the most recent medical information into evidence-based practical recommendations clinicians trust to make the right point-of-care decisions.
Choose from the list below to learn more about subscriptions for a:
Subscribers log in here
Related articles
Related Searches
|AuthorsPeter H Schur, MDPaul F Dellaripa, MD
|Section EditorDavid S Pisetsky, MD, PhD
|Deputy EditorMonica Ramirez Curtis, MD, MPH
Topic Outline
At some time during their course, most patients with systemic lupus erythematosus (SLE) show signs of involvement of the lung, its vasculature, the pleura, and/or the diaphragm [1-5]. Pleurisy, coughing, and/or dyspnea are often the first clues either to lung involvement or to SLE itself [6]. In some cases, however, abnormal pulmonary function tests (PFTs), including the diffusing capacity for carbon monoxide (DLCO) and/or abnormal chest radiographs, may be detected in asymptomatic patients [7]. Pulmonary abnormalities do not correlate with complement levels, antinuclear antibody (ANA) levels, or other specific autoantibody levels such as anti-double-stranded DNA (dsDNA) and anti-Sm [8].
Patients with SLE and lung involvement must always be evaluated for infection, particularly that due to bacteria or viruses. Given that many are immunocompromised, tuberculosis, fungal infections, and other opportunistic infections should also be considered [9,10].
Overviews of the clinical manifestations of SLE in adults and children and a review of pulmonary disease in children with lupus are presented separately. (See "Overview of the clinical manifestations of systemic lupus erythematosus in adults" and "Systemic lupus erythematosus (SLE) in children: Clinical manifestations and diagnosis", section on 'Pulmonary disease'.)
Chest pain on breathing occurs in approximately 50 percent of patients with SLE [11,12]. It may be due to musculoskeletal causes or to pleuritis.
Musculoskeletal pain — In our experience, the most common cause of chest pain in systemic lupus erythematosus (SLE) is from muscles, connective tissues, or the costochondral joints (costochondritis or Tietze's syndrome). The chest pain is characterized by painful deep breaths, aggravated by motion or by change of position (especially during sleep), and elicited by palpation of the painful areas. The patient can be reassured that this specific pain does not represent lung involvement. (See "Major causes of musculoskeletal chest pain in adults".)
Subscribers log in here


text:
the post that leads to nowhere {my ordinary life.}
{The response to yesterdays post was wonderful {huzzah!} and I'm excited to get underway! I'll give some details tomorrow, so make your way back. I'd write about it today but I needed to get the following post out before my brain exploded. You know how that goes.}
At the onset of this post, I know it will wind down a road to a non-existent conclusion.
But just like running, reading or talking to my husband, click-clacking on the keys is just something that I must do, to close out a day. Who knows why or for what return, but I need to show up and prodcue something, maybe more so these days, then before.
I've been thinking about an ordinary life, lately.
Remember in You've Got Mail when Kathleen Kelly questioned her small life? I do. I recall it all the time. I even wrote about it once and I remember the response being quiet and maybe it's because people don't stop to think about a small life or if ordinary is o.k. Maybe people feel a sense of failure if they lead a seemingly small life. Maybe they feel the only satisfaction comes from a life lived large and outwardly grand?
Maybe it's because we are living in our future lives already and taking little time to observe our future space.
Today I woke up with a cold and I had horrendous hair until 9am. I went to the post office and I just ate a peanut butter and jelly sandwich for lunch. For second lunch, I'll have another.
I saw a friend and watched my daughter swim huge strides across a huge pool and felt pangs of pain as I saw her once-small body reaching out to grab a concrete slab, when I can still feel her newborn skin pressed against by chest.
My kids sleep and it's warm and my house needs to be tidied up. It's quiet and the mailman is walking up and down the streets but I can hear the faint roll of a lawnmower.
A very ordinary life. A very simple and sometimes boring one, too.
But why I like that isn't because I'm adverse to excellence or greatness. Quite the opposite, actually. I think I like small and simple because it leaves room for the extraordinary to actually occur. The wiggle room in my life is a blessing so I'll squeeze it out and save it in a jar so when a moment comes for whatever greatness may be calling...I'll be there. Hopefully.
Small and ordinary is good because it doesn't assume that we understand everything and we aren't doing all of the many things we think we should be doing. There's wisdom in that, right?
A line in one of U2's songs resonates with me.
"The more you see, the less you know. The less you find out as you go."
Why I like that, I'm not all together sure, but it might have something to do with the cold hard fact that when I try to break from simple, I muddle everything. I dip my hands and feet into hurried waters and come up soaked with regret for not being more wise and slowing down. I search and look and tend to want to figure things out and I'm getting to the point in my life where failure in that regards is teaching me to stop it. Let go. Stop pushing and be.
When I go out searching, sometimes I come home forgetting what I went out looking for.
Does that make sense? {it's alright if you're saying no}
Ordinary is o.k. After-all, we are all a bit ordinary. We just run from it, which we shouldn't because it binds us together.
It doesn't mean that we can't do extraordinary things....we just have to move life to a place where extraordinary can find a timeslot.
{See. I told you it was a windy road to just about nowhere....}
16 comments:
i love this post. beautifully said. :)ReplyDelete
i often times feel discouraged when it seems as if family/friends are leading busier, more grand lives. but then the Lord reminds me that busy is not necessarily better, and grander doesn't mean any more blessed.
thanks for your words, and the reality check today!Replies
You are 100% right.Delete
We use the wrong measuring stick, all too often.
I am someone that constantly gets ahead of myself so this really resonates with me. Ordinary is just fine. I don't need to do EVERYTHING, I need to do what's before me to the best of my ability and above all, to the glory and honor of God. If I keep that simple goal, ordinary is very, very fulfilling.ReplyDeleteReplies
ALL to His glory-that's the key to this life and it's "success"!!Delete
girlfriend, you are a seriously good writer. this post is so what I needed in the middle of my day :)ReplyDeleteReplies
Thank you so much Kara <3 <3Delete
i have personally noticed that if you just act normal..the normal-ness in other people tend to come out. These days everyone is trying to impress everyone..when you finally find a "normal" person..it is like a breath of fresh air.ReplyDeleteReplies
You are absolutely right-we are all linked with some level of "ordinary". Making people feel comfortable in their "normalness" is important, isn't it?Delete
love that movie! i think i am getting more comfortable with my small life each day.ReplyDeleteReplies
me too. and me too. <3Delete
Every morning, when I open your blog to read and there is something new, I thank God that you came back to blog. I missed you for many months.ReplyDelete
I often remind myself that we are not all called to be a Peter. Some of us were called to be the boy with the fishes and loves - to do something small without knowing the big impact of it. That's me.Replies
Hi Jenni!! Thank you SO much for this comment. I'm glad to be back!Delete
I think our push to do something "great" and amazing is really our sin nature wanting glory. If we realized it isn't about us, I think we would do things so much differently.
- AnonymousJune 1, 2013 at 9:56 PM
Fantastic beat ! I wish to apprentice whilst you amend your website,ReplyDelete
how can i subscribe for a blog website? The account aided me a applicable deal.
I had been tiny bit familiar of this your broadcast offered
bright clear concept
my blog post - Psn Code Generator
- AnonymousJune 4, 2013 at 5:14 PM
I'm not sure exactly why but this website is loading incredibly slow for me. Is anyone else having this issue or is it a issue on my end? I'llReplyDelete
check back later on and see if the problem still exists.
Feel free to surf to my site :: Generateur De Code PSN
- AnonymousJune 9, 2013 at 8:17 AM
I'm gone to convey my little brother, that he should also go to see this webpage on regular basis to obtain updated from newest reports.ReplyDelete
My site ... Psn Code Generator ()
- AnonymousJune 9, 2013 at 7:03 PM
It's a shame you don't have a donate button! I'd without a doubt donate to this fantastic blog! I guess for now i'll settle for bookmarkingReplyDelete
and adding your RSS feed to my Google account.
I look forward to new updates and will talk about this
website with my Facebook group. Chat soon!
Also visit my website - Psn Code Generator


text:
COLLEGE STATION - Former Texas A&M men's basketball player Antanas Kavaliauskas will get his chance to chase Olympic dreams in London this summer as he was recently added to the Lithuanian National Team.
Kavaliauskas, a native of Vilnius, Lithuania, played two seasons at Texas A&M (2005-07) and becomes the first A&M men's basketball player to represent his country in the Olympic Games. Playing in 64 career games for the Aggies, he averaged 9.4 points and 4.9 rebounds per contest and garnered honorable mention All-Big 12 accolades as a senior in 2006-07 while helping lead the Aggies to the Sweet 16.
The 6-foot-10 center, who was the last player cut before Olympic qualifying, was added to the Lithuanian roster following an injury to veteran center Robertas Javtokas. Team Lithuania will begin its run at the Summer Games on July 29 against Argentina as part of Pool B, which also features the United States, France, Tunisia and Nigeria.
The addition of Kavaliauskas gives Texas A&M a total of 23 athletes and one coach representing 14 countries in the 2012 London Games.


text:
Admin Area
User Name:
Printable version -
Email this to a friend
Welcome to Ilchester, Somerset, England! Our not-so-sleepy village nestling in the heart of the English countryside is packed full of history, archaeology, and present day interest - and good places to eat and drink. We hope you will be able to visit soon and stay awhile.
These pages are here not only to help the visitor find out a little about Ilchester, but also to help and inform the local community about what's going on and who's organising what, when and where. You will also find out who's on the Parish Council, and the minutes of the monthly Parish Council meetings.
Are you a new student? Check the IRINEC page in the Community section to learn something that may be to your advantage!!
Contact Us
© Copyright Ilchester Parish Council 2014 Website designed with Vision Websites a Vision ICT Ltd Product
Last modified: 18/11/2013 12:33:06
This website uses cookies to improve your experience. If you continue without changing your setting, we will assume that you are happy to receive all cookies on this website. However, if you would like to, you can change your cookie setting at any time. Accept and remove message.


text:
SUMMARY: The average order size at Binoculars.com is $225, so this online retailer has to work very hard to get orders. This Case Study reveals how they:
- Upsell in their shopping cart
- Improved their tell-a-friend system
- Rev up best-selling SKU sales even higher
Plus, some very surprising results on one test that generated far more additional sales than the team ever expected it to.
|Enter your email below to join thousands of marketers and get FREE newsletters with practical Case Studies, research and training on email, demand gen, SEO, social media and more, as well as MarketingSherpa updates and promotions.


text:
Men's Georgia® CC Pull-On Work Boots, Brown
Item # WX2-217499
- Google+
This item is shipped directly from the factory. To see the expected shipping date, please add to your Shopping Cart. Sorry, no express shipping available. We are unable to ship factory direct items to Alaska, Hawaii, Puerto Rico or APO or FPO addresses.
- Details & Specs
Georgia® CC Pull-On Work Boots. Work boots ready to rumble with your tough job site!
You want "all-day dry"? No problem, with this CC Pull-On Work Wellington Boots from Georgia. A molded, waterproof TPU shell does the dirty work... stops rain, puddles, dew, and any other moisture from finding its way inside. You'll love the Comfort Core Airflow orthotic insert too! Delivers shock-absorbing support that takes the painful impact away from everyday walking and standing on the job.
- Work boots come with a supporting steel shank that provides stability while you work
- Stylish, comfortable leather shaft
- Long-wearing "weave" outsole for extra work boot grip
- Work boots for men feature lightweight, cushioning, compression-molded EVA midsole
- High-abrasion and moisture-wicking mesh lining for cool, dry comfort
- Each Work Boot weighs approx. 31 ozs.
State Size, as available in the Shopping Cart.
- Reviews
<!--BVSEO|dz:Main_Site-en_US|sdk:v126.96.36.199-n|msg:Error: Request errored out - The remote server returned an error: (403) Forbidden. -->
Don't Forget
6-Prs. of Guide Gear® Xtreme Steel Toe Work Socks, WhiteBuyer's Club $16.19 Non-Members $17.99
Thorogood® Shock Zone InsoleBuyer's Club $11.69 Non-Members $12.99
Peet® Boot / Shoe DryerBuyer's Club $44.99 Non-Members $49.99
You May Also Like
Guide Gear® Waterproof Pull-on Work BootsBuyer's Club $71.99 Non-Members $79.99
Ariat® Workhog RT Pull-on Composite Toe BootsBuyer's Club $71.99 Non-Members $79.99
Men's Irish Setter® 17" Rutmaster BootsNon-Members $149.99


text:
Go to Graphical version
Take part in an organised trekking adventure with like-minded people of all ages.
Find out how you can create your own online sponsorship page.
If you need to contact the events team please call 0845 306 0898.
29 - 30 August 2015
Find out how to maximise your fundraising by using the internet and email
If our treks are full or you fancy a different challenge, you might like to consider some alternatives.
Alzheimer's Society works with companies that organise lots of different challenges.
These challenges are open to anyone wanting to raise money for any charity.
Sign up to our monthly e-newsletters.
Quick search
Search by keyword
Get in touch with us if you need further information.
Contact the Society
All content © 2014 Alzheimer's Society. Registered office at Devon House, 58 St Katharine's Way, London E1W 1LB
Alzheimer's Society is a registered Charity No. 296645. Registered as a company limited by guarantee and registered in England No. 2115499
Powered by Jadu Content Management. Made with XHTML and CSS.
What's new
Site map
Search facility
Frequently asked questions
Complaints procedure (Contacting the Council page)
Terms & Privacy
Access key details
Top of the page


text:
Royal Challengers Bangalore vs Kolkata Knight Riders Live IPL 2013 Match 12-11th Apr
Watch Royal Challengers Bangalore vs Kolkata Knight Riders Live Scorecard IPL 2013 12th Match on 11th April 2013 at M Chinnaswamy Stadium, Bangalore. Watch RCB vs KKR IPL 2013 Live Scorecard Match 12 on 11-4-2013 at Bangalore. Watch IPL 2013 Live Streaming on Set Max and Star Cricket TV Channels at Home. Set Max is the Official Broadcaster of IPL T20 2013.
Royal Challengers Bangalore
Royal Challengers Bangalore Known as RCB. Indian Premier League is a cricket tournament being organised by the Board of Control for Cricket in India (BCCI) and backed by the International Cricket Council (ICC). For the inaugural tournament held in April–June 2008, the BCCI had finalised a list of 8 teams who will be participating in the tournament. The teams representing 8 different cities of India, including Bangalore, were put up on auction in Mumbai on 20 February 2008 and the Bangalore team was won by Vijay Mallya, who paid US$111.6 million for it. This was the second highest bid for a team in the IPL, next only to Mukesh Ambani's Reliance Industries' bid of $111.9 million for the Mumbai team. Bollywood actresses Katrina Kaif and Deepika Padukone, and Sandalwood film stars Ramya and Puneeth Rajkumar are the brand ambassadors of the team.
Watch Royal Challengers Bangalore vs Kolkata Knight Riders Live Scorecard IPL 2013 Match 12-11th Apr
Kolkata Knight Riders
Kolkata Knight Riders often abbreviated as KKR. Kolkata Knight Riders is a cricket franchise representing Kolkata in the Indian Premier League and KKR owned by Bollywood super star, Bollywood King Shah Rukh Khan's compnay Red Chillies Entertainment. Juhi Chawla who is also a Bollywood actress and her husband Jay Mehta from the Mehta Group are also partner. The team captain is Gautam Gamhir and coached by Trevor Bayliss, a former Australian cricketer. Wasim Akram who is bowling legend, they choose for the team bowling consultant and mentor. Kolkata Knight Riders Icon player is Sourav Ganguly. In 2012 KKR first time won the IPL Title against Chennai Super Kings by 5 wickets at CSK home ground in Chennai. The opening ceremony of the 2013 Indian Premier League which will be Pepsi IPL-6 will be held at the Salt Lake Stadium in Kolkata on evening of Tuesday, April 2 of 2013,which will represent the KKR team.


text:
Intranasal Delivery of Influenza Subunit Vaccine Formulated with GEM Particles as an Adjuvant
- Vinay Saluja,
- Jean P. Amorij,
- Maarten L. van Roosmalen,
- Kees Leenhouts,
- Anke Huckriede,
- Wouter L. J. Hinrichs,
- Henderik W. Frijlink
- … show all 7 hide
Nasal administration of influenza vaccine has the potential to facilitate influenza control and prevention. However, when administered intranasally (i.n.), commercially available inactivated vaccines only generate systemic and mucosal immune responses if strong adjuvants are used, which are often associated with safety problems. We describe the successful use of a safe adjuvant Gram-positive enhancer matrix (GEM) particles derived from the food-grade bacterium Lactococcus lactis for i.n. vaccination with subunit influenza vaccine in mice. It is shown that simple admixing of the vaccine with the GEM particles results in a strongly enhanced immune response. Already after one booster, the i.n. delivered GEM subunit vaccine resulted in hemagglutination inhibition titers in serum at a level equal to the conventional intramuscular (i.m.) route. Moreover, i.n. immunization with GEM subunit vaccine elicited superior mucosal and Th1 skewed immune responses compared to those induced by i.m. and i.n. administered subunit vaccine alone. In conclusion, GEM particles act as a potent adjuvant for i.n. influenza immunization.
Article MetricsCitations
Co-published with
Other actions
- WHO, influenza, fact sheet 211, revised 2003.
- Couch RB, Kasel JA, Glezen WP, Cate TR, Six HR, Taber LH, et al. Influenza: its control in persons and populations. J Infect Dis. 1986;153(3):431–40.
- Cox RJ, Brokstad KA, Ogra P. Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines. Scand J Immunol. 2004;59(1):1–15. CrossRef
- Atmar RL, Keitel WA, Cate TR, Munoz FM, Ruben F, Couch RB. A dose–response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adults. Vaccine. 2007;25(29):5367–73. CrossRef
- Cox RJ, Haaheim LR, Ericsson JC, Madhun AS, Brokstad KA. The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man. Vaccine. 2006;24(44–46):6577–80. CrossRef
- Tamura S, Kurata T. Defense mechanisms against influenza virus infection in the respiratory tract mucosa. Jpn J Infect Dis. 2004;57(6):236–47.
- Yetter RA, Lehrer S, Ramphal R, Small PA Jr. Outcome of influenza infection: effect of site of initial infection and heterotypic immunity. Infect Immun. 1980;29(2):654–62.
- Zee YC, Osebold JW, Dotson WM. Antibody responses and interferon titers in the respiratory tracts of mice after aerosolized exposure to influenza virus. Infect Immun. 1979;25(1):202–7.
- Greenbaum E, Engelhard D, Levy R, Schlezinger M, Morag A, Zakay-Rones Z. Mucosal (SIgA) and serum (IgG) immunologic responses in young adults following intranasal administration of one or two doses of inactivated, trivalent anti-influenza vaccine. Vaccine. 2004;22(20):2566–77. CrossRef
- Giudice EL, Campbell JD. Needle-free vaccine delivery. Adv Drug Deliv Rev. 2006;58(1):68–89. CrossRef
- Taylor HP, Dimmock NJ. Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG. J Exp Med. 1985;161(1):198–209. CrossRef
- Renegar KB, Small PA Jr, Boykins LG, Wright PF. Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract. J Immunol. 2004;173(3):1978–86.
- Eyles JE, Williamson ED, Alpar HO. Intranasal administration of influenza vaccines: current status. BioDrugs. 2000;13(1):35–59. CrossRef
- Tamura S, Funato H, Hirabayashi Y, Suzuki Y, Nagamine T, Aizawa C, et al. Cross-protection against influenza A virus infection by passively transferred respiratory tract IgA antibodies to different hemagglutinin molecules. Eur J Immunol. 1991;21(6):1337–44. CrossRef
- Tamura SI, Asanuma H, Ito Y, Hirabayashi Y, Suzuki Y, Nagamine T, et al. Superior cross-protective effect of nasal vaccination to subcutaneous inoculation with influenza hemagglutinin vaccine. Eur J Immunol. 1992;22(2):477–81. CrossRef
- Moran TM, Park H, Fernandez-Sesma A, Schulman JL. Th2 responses to inactivated influenza virus can Be converted to Th1 responses and facilitate recovery from heterosubtypic virus infection. J Infect Dis. 1999;180(3):579–85. CrossRef
- Liew FY, Russell SM, Appleyard G, Brand CM, Beale J. Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity. Eur J Immunol. 1984;14(4):350–6. CrossRef
- Tumpey TM, Renshaw M, Clements JD, Katz JM. Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection. J Virol. 2001;75(11):5141–50. CrossRef
- McElhaney JE. The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine. 2005;23 Suppl 1:S10–25. CrossRef
- Szewczuk MR, Wade AW. Aging and the mucosal-associated lymphoid system. Ann N Y Acad Sci. 1983;409:333–44. CrossRef
- Centers for Disease Control and Prevention. Estimates of influenza vaccination target population sizes in 2006 and recent vaccine uptake levels. http://www.cdc.gov/flu/professionals/vaccination/pdf/targetpopchart.pdf.
- Belshe RB, Ambrose CS, Yi T. Safety and efficacy of live attenuated influenza vaccine in children 2–7 years of age. Vaccine. 2008;26 Suppl 4:D10–6. CrossRef
- Matassov D, Cupo A, Galarza JM. A novel intranasal virus-like particle (VLP) vaccine designed to protect against the pandemic 1918 influenza A virus (H1N1). Viral Immunol. 2007;20(3):441–52. CrossRef
- Joseph A, Itskovitz-Cooper N, Samira S, Flasterstein O, Eliyahu H, Simberg D, et al. A new intranasal influenza vaccine based on a novel polycationic lipid—ceramide carbamoyl-spermine (CCS). I. Immunogenicity and efficacy studies in mice. Vaccine. 2006;24(18):3990–4006. CrossRef
- Haan L, Verweij WR, Holtrop M, Brands R, van Scharrenburg GJ, Palache AM, et al. Nasal or intramuscular immunization of mice with influenza subunit antigen and the B subunit of Escherichia coli heat-labile toxin induces IgA- or IgG-mediated protective mucosal immunity. Vaccine. 2001;19(20–22):2898–907. CrossRef
- Plante M, Jones T, Allard F, Torossian K, Gauthier J, St-Felix N, et al. Nasal immunization with subunit proteosome influenza vaccines induces serum HAI, mucosal IgA and protection against influenza challenge. Vaccine. 2001;20(1–2):218–25. CrossRef
- Fujihashi K, Koga T, van Ginkel FW, Hagiwara Y, McGhee JR. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine. 2002;20(19–20):2431–8. CrossRef
- Mutsch M, Zhou W, Rhodes P, Bopp M, Chen RT, Linder T, et al. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N Engl J Med. 2004;350(9):896–903. CrossRef
- Van Roosmalen ML, Kanninga R, El Khattabi M, Neef J, Audouy S, Bosma T, et al. Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria. Methods. 2006;38(2):144–9. CrossRef
- Bosma T, Kanninga R, Neef J, Audouy SA, van Roosmalen ML, Steen A, et al. Novel surface display system for proteins on non-genetically modified gram-positive bacteria. Appl Environ Microbiol. 2006;72(1):880–9. CrossRef
- Audouy SA, van Roosmalen ML, Neef J, Kanninga R, Post E, van Deemter M, et al. Lactococcus lactis GEM particles displaying pneumococcal antigens induce local and systemic immune responses following intranasal immunization. Vaccine. 2006;24(26):5434–41. CrossRef
- Audouy SA, van Selm S, van Roosmalen ML, Post E, Kanninga R, Neef J, et al. Development of lactococcal GEM-based pneumococcal vaccines. Vaccine. 2007;25(13):2497–506. CrossRef
- Ramasamy R, Yasawardena S, Zomer A, Venema G, Kok J, Leenhouts K. Immunogenicity of a malaria parasite antigen displayed by Lactococcus lactis in oral immunisations. Vaccine. 2006;24(18):3900–8. CrossRef
- Amorij JP, Saluja V, Petersen AH, Hinrichs WL, Huckriede A, Frijlink HW. Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice. Vaccine. 2007;25(52):8707–17. CrossRef
- Amorij JP, Westra TA, Hinrichs WL, Huckriede A, Frijlink HW. Towards an oral influenza vaccine: comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine model. Vaccine. 2007;26(1):67–76. CrossRef
- Amidi M, Romeijn SG, Verhoef JC, Junginger HE, Bungener L, Huckriede A, et al. N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model. Vaccine. 2007;25(1):144–53. CrossRef
- Sanders MT, Deliyannis G, Pearse MJ, McNamara MK, Brown LE. Single dose intranasal immunization with ISCOMATRIX vaccines to elicit antibody-mediated clearance of influenza virus requires delivery to the lower respiratory tract. Vaccine. 2009;27(18):2475–82. CrossRef
- Hagenaars N, Mastrobattista E, Glansbeek H, Heldens J, van den Bosch H, Schijns V, et al. Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model. Vaccine. 2008;26(51):6555–63. CrossRef
- Coucke D, Schotsaert M, Libert C, Pringels E, Vervaet C, Foreman P, et al. Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine. Vaccine. 2009;27(8):1279–86. CrossRef
- Verweij WR, de Haan L, Holtrop M, Agsteribbe E, Brands R, van Scharrenburg GJ, et al. Mucosal immunoadjuvant activity of recombinant Escherichia coli heat-labile enterotoxin and its B subunit: induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigen. Vaccine. 1998;16(20):2069–76. CrossRef
- The European Agency for the Evaluation of Medicinal Products (EMEA) Committee for Proprietary Medicinal Products (CPMP). Note for guidance on harmonization of requirements for influenza vaccines. CPMP/BWP/214/96, London, March 12, 1997.
- Holmgren J, Czerkinsky C. Mucosal immunity and vaccines. Nat Med. 2005;11(4 Suppl):S45–53. CrossRef
- Bienenstock J, McDermott MR. Bronchus- and nasal-associated lymphoid tissues. Immunol Rev. 2005;206:22–31. CrossRef
- Bungener L, Geeraedts F, Ter Veer W, Medema J, Wilschut J, Huckriede A. Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection. Vaccine. 2008;26(19):2350–9. CrossRef
- Geeraedts F, Bungener L, Pool J, ter Veer W, Wilschut J, Huckriede A. Whole inactivated virus influenza vaccine is superior to subunit vaccine in inducing immune responses and secretion of proinflammatory cytokines by DCs. Influenza Other Respi Viruses. 2008;2(2):41–51. CrossRef
- Guy B. The perfect mix: recent progress in adjuvant research. Nat Rev Microbiol. 2007;5(7):505–17. CrossRef
- Hovden AO, Cox RJ, Haaheim LR. Whole influenza virus vaccine is more immunogenic than split influenza virus vaccine and induces primarily an IgG2a response in BALB/c mice. Scand J Immunol. 2005;62(1):36–44. CrossRef
- Rimmelzwaan GF, Fouchier RA, Osterhaus AD. Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development. Curr Opin Biotechnol. 2007;18(6):529–36. CrossRef
- Hagenaars N, Mastrobattista E, Verheul RJ, Mooren I, Glansbeek HL, Heldens JG, et al. Physicochemical and immunological characterization of N, N, N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration. Pharm Res. 2009;26(6):1353–64. CrossRef
- Hu KF, Lovgren-Bengtsson K, Morein B. Immunostimulating complexes (ISCOMs) for nasal vaccination. Adv Drug Deliv Rev. 2001;51(1–3):149–59. CrossRef
- Ko SY, Ko HJ, Chang WS, Park SH, Kweon MN, Kang CY. alpha-Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor. J Immunol. 2005;175(5):3309–17.
- Garmise RJ, Staats HF, Hickey AJ. Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. AAPS PharmSciTech. 2007;8(4):E81. CrossRef
- Mercenier A, Muller-Alouf H, Grangette C. Lactic acid bacteria as live vaccines. Curr Issues Mol Biol. 2000;2(1):17–25.
- Seegers JF. Lactobacilli as live vaccine delivery vectors: progress and prospects. Trends Biotechnol. 2002;20(12):508–15. CrossRef
- Title
- Intranasal Delivery of Influenza Subunit Vaccine Formulated with GEM Particles as an Adjuvant
- Journal
The AAPS Journal
Volume 12, Issue 2 , pp 109-116
- Cover Date
- 2010-06-01
- 10.1208/s12248-009-9168-2
- Online ISSN
- 1550-7416
- Publisher
- Springer US
- Additional Links
- Topics
- Keywords
- influenza vaccine
- intranasal vaccine
- Lactococcus lactis GEM particles
- Industry Sectors
- Authors
- Vinay Saluja (1)
- Jean P. Amorij (1) (4)
- Maarten L. van Roosmalen (2)
- Kees Leenhouts (2)
- Anke Huckriede (3)
- Wouter L. J. Hinrichs (1)
- Henderik W. Frijlink (1)
- Author Affiliations
- 1. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands
- 4. Research and Development Unit, The Netherlands Vaccine Institute, Bilthoven, The Netherlands
- 2. Mucosis BV, Meditech Center, L.J. Zielstraweg 1, 9713 GX, Groningen, The Netherlands
- 3. Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands


text:
The peer-reviewed British Journal of Biomedical Science is now predominantly an electronic publication. Although limited quarterly printed circulation will continue, accepted articles appear online at the earliest opportunity (Epub ahead of print). The most recent examples can be found in the list below; however, archival searching, including by year, volume and issue, may be performed using the facility in the column on the right of the screen.
Original Articles
ERK and RAF1 genes: analysis of methylation and expression profiles in patients with oral squamous cell carcinoma
Association of plasma proteins at multiple stages of glycation and antioxidant status with erythrocyte oxidative stress in patients with type 2 diabetes
Human herpesvirus 6 infection in febrile children: frequency in an Iranian referral hospital
Rubella antibody status of patients attending a south-west London antenatal clinic, 20072012
Sickle cell solubility test: evaluation of an in-house method
Molecular characterisation of a type III restriction-modification system in Campylobacter upsaliensis
Construction and expression of a recombinant urease gene cluster from Campylobacter sputorum biovar paraureolyticus
Immunohistochemistry for CDX2 expression in non-goblet-cell Barretts oesophagus
Antimicrobial susceptibility of methicillin-resistant Staphylococcus pseudintermedius isolated from veterinary clinical cases in the UK
Laboratory diagnosis of Lyme borreliosis in Scottish patients: a novel approach
In Brief
Observations on the variation in volumes of self-collected oral fluid samples submitted for HIV antibody detection
Vitamin D immunoassay systems: a comparison
Diagnosis of latent tuberculosis in individuals with recent exposure: tuberculin skin test versus interferon-g release assay
Misidentification of Providencia stuartii as Serratia fonticola by Vitek 2
Detection of the prodigiosin biosynthesis protein (pigC) from Serratia marcescens: development of a novel PCR assay
Haptoglobin 2-2 phenotype is associated with decreased serum iron levels in end-stage renal disease patients resistant to rhEPO therapy
Comparability of high-sensitivity CRP methods to detect maturity-onset diabetes of the young due to HNF1A mutations
Bacterial aetiology of community-acquired pneumonia in hospitalised patients with chronic obstructive pulmonary disease in central Greece
Zinc chloride inhibits Helicobacter pylori growth and reduces expression of interleukin-1beta by gastric epithelial cells
Increased susceptibility to antibiotics in Gram-negative and Gram-positive pathogens, including Pseudomonas aeruginosa, at lower temperature: is antibiotic resistance reversal possible?
Book Reviews
Identification of Pathogenic Fungi
Microbiology Nuts & Bolts: Key Concepts of Microbiology and Infection
Leadership in Health and Social Care
Thrive in Biochemistry and Molecular Biology
Extreme Tissue Engineering: Concepts and Strategies for Tissue Fabrication


text: A teacher writes: "I was grading a student's paper last night (4th grade) and was disheartened when he included a sentence about clearing airport security before he could begin on his adventure. How sad, that 'airport security' has become such a big part of our lives that it appears in a 9-year-old's essay about traveling somewhere. We really are 'locked in.'"3:27 pm on December 11, 2012 Email Becky Akers


text:
Just enter your Email address and your zip code and you'll receive the very best money saving deals you can find in Myrtle Beach.
FUN, FEAST & ADVENTURE! Be amazed matey, as pirates battle each other, on deck, in water and in the sky above full sized pirate ships, in a 15 foot deep indoor hideaway lagoon. Landlubbers be prepared for spectacular acrobatic competitions, live animals, beautiful mermaids and more. Join the crew for a delicious four course pirates feast!
Voted 1 of the top 10 water parks by 2011 Tripadvisor. A 16 acre park filled with more than 33 exciting rides, including high-speed slides, fast breaking tides in a wipe out wave pool, 950' lazy river, Kiddie pools and so much more. The park is fully staffed with certified lifeguards and life vest are available at no charge. You can enjoy bumper boats, go carts & miniature golf at Wild Water & Wheels. Your visit will be the most unforgettable expience for the whole family. Parking is always free. Please be sure to ask your desk clerk for a special coupon for discounted rates.
Sea Captain's House Restaurant is a local legend. The oceanfront restaurant, founded in 1962, is home to a diverse selection of menu options featuring chicken, beef, pork and seafood. It has an array of favorites cherished by customers, with the she-crab soup having a rock star following – people travel from near and far just to have a cup or bowl of the famous soup. Open seven days a week for breakfast, lunch and dinner, you certainly don't have to be a local to appreciate this stellar eatery.
Capt. Brant is proud to offer you two identical World Cat 33 TE boats for your fishing comfort and pleasure. These boats feature huge fishing and lounging areas with an overall length of 33 feet and and 11 foot beam. They are smooth, dry, fast and offer the conveniences of a larger boat (cabin/bathroom) and the fishability of a small boat (360 degree walk around fishing). We truly believe these are THE BEST all around boats that we can offer. Join us aboard the OIFC World Cat or Carolina Cat for great fishing adventures.
Grand 14 in Myrtle Beach at The Market Common is a groovy place, and the coolness is apparent even before you set foot in the theatre. At the ticket booth, you meet cinema staff that is not only friendly but also knowledgeable about each movie. Upon entering, your eyes are drawn to a bright décor featuring autumn colors and other vivid hues. The seats in every theatre are exquisite, with each also doubling as a comfy rocking chair.
Broadway at the Beach is the perfect place to spend your Myrtle Beach vacation without driving all over town. Filled with some of Myrtle Beach's best shops, restaurants, bars and attractions, this 350-acre complex has something for everyone in your group. Shop at top national and local chains, dine at excellent eateries, play all day and dance the night away all in one location in the heart of the Grand Strand. Located along Highway 17 Bypass between 21st and 29th Avenues North, Broadway at the Beach is open from 10 a.m. to 11 p.m. daily during the summer months. For more information, call 843-913-5218 or visit www.broadwayatthebeach.com.


text:
Reaching out across the border : Canadian perspectives in adult education
Featured Queue:
Publication Type:Book
Source:New directions for adult and continuing education ; no. 124, Jossey-Bass, San Francisco, p.105 (2009)
Call Number:Cubb LC5254 .R43 2009
Keywords:Adult education--Canada
Contents: Critical adult education in Canada in the time of CASAE / Donovan Plumb -- Literacy lives here : using video and dialogue to promote and celebrate adult and literacy education in the Canadian Western Arctic / Suzanne Robinson -- Social change in historical perspective / Dorothy MacKeracher -- Perspectives on adult education in Quebec / Mohamed Hrimech -- "More universal for some than others" : Canada's health care system and the role of adult education / B. Allan Quigley ... [et al.] -- Critical environmental adult education in Canada : student environmental activism / Elizabeth Lange, Aaron Chubb -- Learning to teach : an illustrative case from the Canadian community college system / Ellen Carusetta, Patricia Cranton -- From manifesto days to millennium days : Canadian perspectives on community development / Leona M. English -- Reaching out across the border / Leona M. English, Patricia Cranton.
Publication Language:


text:
From peeing in public to bribes, everything we wish we'd known about potty training (17 Photos)
Comstock Images/Getty Images
Don't get your hopes up, because the chance of it happening to you is pretty remote, but there most definitely are some kids who take to potty training like ducks take to water. Some kids are just plain ready, and it may surprise you how easily the physical mechanics happen as a result. In other words, all that reward candy you bought in a fit of hope might be completely unnecessary -- which means you can enjoy it all yourself.
Yummy recipes, DIY projects, home decor, fashion and more curated by iVillage staffers.
The very dirty truth about fashion internships... DUN DUN @srslytheshow http://t.co/wfewf


text:
Greetings. You need to upgrade your Flash Player.
Click here to install or upgrade
|Starring: Rick Colt, Jordan Austin
|Stashed: 53 times
|Director: N/A
|Added May 15, 2007
|Studio: Thrust Studios
|Rated 13 times
|Length: 19:23
|Niches: Anal, Athletes, Feature, Hunk, Masturbation, Muscle Men, Nipple Play, Oral, Outdoor, Rimming, White


text:
Gear Question
I have a Suunto Vector watch/altimeter and...
Ted Kuhn
Member since
I have a Suunto Vector watch/altimeter and need a new battery. Suunto has a kit with battery, 0 ring and back of watch. Do you sell those kits including a new back for the battery cover? I damaged mine changing the battery the last time and not sure it is still waterproof.
Member since
Yes. Look here: http://www.backcountry.com/suunto-battery-replacement-kit-for-vector-x-lander-altimax
View More Details on Suunto Vector Altimeter Watch


text:
Snolo Sled
Snolo is a high performance alpine sled made of carbon and designed to bring unprecedented levels of performance, manoeuvrability…and styling! "Lean into corners like a motorcycle while sitting in a race car position. Brush the snow with your hand as you lean into a corner whether its powder or packed, backcountry or resort". It is foldable to be carried like a backpack and will be available on December 7th for $3000. Enjoy!


text:
B & B Canziane Bed & Breakfast Carbonera
Official Contact Details - B & B CanzianePhone: 3492494389
The B & B Canzian is a small villa on two floors. Upstairs are two rooms, both with private bathroom, air conditioner, refrigerator, TV, free internet access. On the same floor is the breakfast room with fireplace.
- Price from 50 EUR / Day
- 2 bedrooms
(click on a photo to view it)
Last updated: 01/21/2009
This is your property ?
The B & B Canzian is a small villa on two floors. Upstairs are two rooms, both with private bathroom, air conditioner, refrigerator, TV, free internet access. On the same floor is the breakfast room with fireplace. The rooms are spacious and you can easily add a third bed on request, or a cot for a child and we both. Everything is well-kept and pulito.Il Canzian B & B also has ample parking and is located Carbonera (TV), in the countryside but only 3.5 km. from the beautiful city of Treviso, a very peaceful and surrounded by greenery.
The B & B Canzian is connected to the city of Treviso bus line number 10, the stop is directly in front of the b & b. From the b & b Canzian Venice is easily reached by train from the station of Treviso in about 30 minutes cheaply and easily, the car is right next to the station. The B&B Canziane is near Treviso and Venice.
Prices & deals
- Lowest Daily Price:
- Highest Daily Price:
- Lowest Weekly Price:
- Highest Weekly Price:
- Cleaning fee:
- Charging Method:
- Payment Types:
- Cash
- Credit Card
- Cheque
- Travellers cheque
- Paypal
- Wire Transfer
Location & area
Beautiful b & b in the green, quiet and without annoying noises, near the beautiful historical city of Treviso and Venice
- Address:
- 54 Via Grande di Carbonera 54, 31030, Carbonera, Italy
- Accommodation located in:
- city, near cultural interest, near fishing area, near historical interest, near restaurants & bars, near shopping area, rural!
Amenities & services
# of Units: 1... and each unit includes:
- Bedrooms: 2
- Bathrooms: 0
- Single beds: 0
- Double beds: 0
- Baby cots: 0
- Single sofa beds: 0
- Double sofa beds: 0
- Bath:
- Hair Drier:
- Shower:
- Towels:
- Washing Machine:
- Work Desk:
- Bed Sheets:
- Bikes:
- Cable/Satelite TV:
- Internet Broadband:
- Internet Dial Up:
- Ironing Board:
- Stereo/Radio System:
- Library:
- Telephone:
- DVD Player:
- Fax:
- Butler Service:
- House Chef:
- Local Guides:
- Local Transportation:
- 24h Concierge:
- Tours & Excursions:
- Fridge & Freezer:
- Crockery & Utensils:
- Dish Washer:
- Microwave:
- Oven:
- American Kitchen:
Living room
- Fireplace:
- Sofa Bed:
- Table & Chairs:
- Private Beach:
- Barbecue:
- Sauna:
- Garden:
- Shared Bathroom:
- Spa / Jacuzzi:
- Swimming Pool:
- Lift / Elevator:
- Disabled Facilities:
- Tennis Court:
- Terrace:
- Parking:
- Pets Welcome:
- Safe:
- Sea View:
- Central Heating:
- City View:
- Daily Cleaning:
- Air Conditioning:
- DVD/Music Collection:
- Ensuite Bathroom:
- Balcony:
Review - B & B Canziane
B & B Canziane - Contact the owner
Important Notice : Avoiding Fraud
It's rare, but some helpful hints to watch out for with regards to fraud:
- It is important to NEVER wire funds or use/employ other fund transfer mechanisms such as western union: Always use a credit card to protect yourself against fraud. If owners pressure you into providing a deposit or refuse to accept credit cards, there is a high probability that this is a scam.
- If at all suspicious of fraud, ask to see their website, or any other literature they can provide or send to you. Ask them for contact details for guests who have previously stayed on their property insisting on telephone numbers. Be suspicious of emails that originate from free email services (yahoo, hotmail, gmail, etc)
- Research the property thoroughly on the internet to see if there is any history or mention of scams associated with the property.


text:
Welcome to my chronological portfolio which showcases my latest freelance projects. At the bottom you can see work created as a response to my Fashion Promotion course briefs as well as freelance work completed whilst at uni. I graduated from BA (Hons) Fashion Design, Styling and Promotion at Middlesex University with first class honours in 2012.
I work in the broad field of Promotion, Art Direction and Visual Merchandising. My skills include photography and editing, video, prop and fashion styling, art direction, visual merchandising, set making, pr, craft and online promotion.
To request a CV or to discuss a collaboration please email email@example.com
Please do not reproduce any of my work without permission.
Visual Merchandising for Task pr Spring Summer 2013 Press Day
Commissioned by Task Pr to act as Visual Merchandiser for their most recent press day which represents both womens and mens casual and luxury brands. Included the creation of small scale decorations (bunting), organisation and style of flowers, signage for most of the brands represented (created by hand), merchandising rails and dressing mannequins and sorting various other props such as candles, frames and jars.
Video creation featuring Assya London for MyFlashTrash
Filming and editing a 3 minute video featuring the behind the scenes of Assya London, as commissioned by MyFlashTrash.com. Video used for promotion of the NottingHill based jewellery brand on both parties' websites.
Shoot Set Making and Video Creation for FlashTrash Girl
Creating the studio set for new brand FlashTrash Girl's first campaign photoshoot. Creating backcloths (tie-dye and confetti curtains) and sourcing props to fit the theme. I also documented the campaign shoot with photography and created the official behind-the-scenes video.
Official campaign imagery by Alex Leese
Official campaign behind – the -scenes video (shortened version)
Trade Show Set Making for FlashTrash Girl
Sourcing and making props and furniture to create a branded set for the trade launch of a new jewellery brand FlashTrash Girl. As well as designing and making the set and point of sale stands beforehand, I set up and merchandised the stand on the day.
See my Flickr album for more.
Wish Magazine Launch Party
Organisation for the launch of my new magazine, Wish of which 1000 copies were sent to print to be sold to girls worldwide. I conceived and organised a party in London to give 70 potential readers and collaborators a taste of the world of Wish. I organised a knitting class, Scent Profiling service with Penhaligon's, live illustrating with university students and fun food. I came up with the theme, sourced props, achieved drinks sponsorship from Hendricks gin plus a cake and goodie bag sponsors and delegated over a team of 6 to create the decorations and food. The night was a huge success, resulting in great praise and many blog posts by guests. See my dedicated blog post about the event here.
Photographs by Miguel Santana
Organisation / Delegation / Art direction / Merchandising / Invitation and Guest-list Management / Food prep / Craft
Wish Magazine Creation and Content
Wish Magazine – a creation of two best friends, sponsored by Penhaligon's. Examples of opening page spreads for content that I created for the new girly lifestyle Magazine Wish. Wish was conceived by my best friend and brought into fruition between us as part of our final major project at university. I also commissioned work and time-managed the project. Half of the 1000 copies ordered were sold during a week long pre-sale online.
Art Direction / Styling / Copy Writing / Planning / Commissioning
Outfitting Britain
The beginning of a Mock T.V show to be aired in the UK to promote British fashion labels and manufacturers today. This was a reaction to an ongoing personal interest with the state of the British Fashion Industry, hope and the idea of Heritage.
Organisation / Editing / Presenting / Making
Fashioning Things
A photography project which looked into the unseen lives of people who help the British Fashion Industry go round. Featuring the personal belongings of Maxine Groucutt at Liberty, Alexis Knox – Stylist, Elizabeth Lau of her own label, Louie Banks – Photographer and Andrea Pfeffer of Pfeffer PR. The project was presented as a series of 5 large prints accompanied by an exhibition catalogue with stories about the belongings by each participant.
Photography / Styling / Editing / Graphics
Richard Nicoll SMOKE
A perfume bottle design and creation to be pitched to Richard Nicoll as his first ever fragrance inspired by the movement of his clothes and the mystery and density of crystals. I created a print advertising campaign to accompany it, taking the bottle back to it's 'roots' of creation – from the discovery and re-appropriation of a series of found bottles in the woods.
Making / Design / Photography / Editing / Art Direction
CellarDoor Magazine – Hide and Seek
Styling and Art Direction published in CellarDoor Magazine. Shot in Goddards House in Surrey. Photography by Stacey Staines.
Styling / Art Direction / Model Scouting / Making / Editing
Visual Merchandising at Liberty, London
Examples of Visual Merchandising as part of freelance work for Liberty. Below are bolts of Liberty fabric pinned into designs to promote the cloth. Underneath shows part of the Home section whereby I helped rearrange and merchandise the whole new season stock.
The Freedom Thought
A newspaper style journal created after the initial internship at Liberty which later lead to Freelance work. It is an A4 sized paper which folds out interestingly to become A3. It documents photographs I took and thoughts I had whilst working there.
Design / Graphics / Copy Writing


text:
2007: Did not race in any events during the indoor and outdoor seasons ... received a redshirt.
2006: Had a successful freshman season as a Blazer, setting the UAB indoor freshman record in the pentathlon with 2,894 points ... also had a multiple personal-bests at the first indoor meet of the year, the Clemson Opener, with career-high marks in the shot put (6.42m), long jump (5.18m) and the triple jump (11.31m) ... finished ninth in the heptathlon at the Alabama Relays with a point total of 4,031 ... placed sixth in the heptathlon at the Conference USA Outdoor Championships with a career-best 4,179 points ... also clocked a personal-best time of 1:03.36 in the preliminaries of the 400-meter hurdles at the C-USA Outdoor Championships, placing seventh in the finals with a time of 1:13.27.
High School: Attended Warwick High School in Newport News, Va., where she ran four years for coach Wendell Kirk Holmes ... finished 21st out of 140 in the state 300-meter hurdles ... finished 30 out of 101 in the state triple jump ... a member of the 4x400-meter relay team that won their heat at the Penn Relays in 2004 and '05 ... also played varsity basketball ... a member of the National Honor Society, the National Honor Roll and the National Society of High School Scholars.
Personal: Full name is Katryce A'Lita Sykes ... born June 18, 1987 in Newport News, Va. ... parents are Karen and Larry Sykes ... major is biology.


text:
|Stratford Shoal, CT
Description: The Stratford Shoal Lighthouse is frequently classified as a New York lighthouse, and the land ("less than one acre") for the lighthouse was indeed ceded to the federal government by the State of New York on May 11, 1874. However, official maps today place the lighthouse on the Connecticut side of Long Island Sound by a good 1,000 feet. With valid arguments on both sides, the debate over whether the lighthouse should be classified as a Connecticut one or a New York one will likely never be settled.
The earliest known maps of Long Island Sound, charted by Adrian Block during his explorations of the area in 1614, show two islands where the Stratford Shoal Lighthouse now stands. Over the following hundred years or so, the sea washed the islands off the map, leaving behind the dangerous Middleground Shoal measuring three-quarters of a mile long. The rocks were located roughly in the middle of Long Island Sound, 5.5 miles from Stratford Point, CT and 5 miles from Old Field Point, NY, and covered by less than two feet of water a constant and dangerous threat to Sound ship traffic.
The earliest known attempt to mark the rocks was around 1820, when a couple of spar buoys were placed on the north and south sides of the shoal. In 1831, a contract was awarded to a man named Hicks to erect an iron spindle on the reef, but no one seems to know whether the spindle was ever put in place.
In 1872, the Lighthouse Board recommended that a lighthouse be built to replace the aging and troublesome lightship, and $150,000 was requested for the project. The schooner Mignonette was being used at the construction site to house men and store supplies. As the lighthouse was nearing completion, the ship was driven onto the shoal by a severe winter storm on November 8, 1877 and sank, although no lives were lost. The crew took up residence in the lighthouse, but due to this and prior weather-related mishaps, the activation of the lighthouse was delayed until December 15, 1877.
The lighthouse's foundation, built with huge undressed blocks of granite attached together with thick cast-iron staples encased in lead, stands nineteen feet tell. The interior of the foundation was filled with concrete, with a space left vacant for a brick lined basement and two storage cisterns.
The architecture used at Stratford Shoal Lighthouse shows a touch of Gothic influence, and the lighthouse is nearly identical to the one at Race Rock in New York. The bottom portion of the tower is square, while the upper section is octagonal. The tower rises three stories high and is attached to the south side of the building. A cast-iron ornamental frieze covers the cornice between the top of the lantern room and the eaves of the roof, featuring panels of embossed leaves, circles, and double lines. The keepers dwelling has a living room, kitchen, five bedrooms, a sitting room, and a supply room. An iron spiral staircase leads up the tower to the lantern room.
LV15 was retired upon completion of the lighthouse and sent to the lighthouse depot at Staten Island, where it was used as a floating barracks during the construction of the Great Beds Lighthouse. Finally, the ship was sold at auction for $1,010 in 1881.
The first keeper at Stratford Shoal was an Irish immigrant named William McGloin, who had previously been captain of the LV15 lightship. Even though the keeper had two assistants, the station was very isolated and windswept, and there was a quick turnover of personnel over the years. Visitors were urged to bring stacks of the latest newspapers with them to help the keepers stay in touch with news on the mainland.
The isolation may have driven at least one assistant keeper mad. In 1905, the head keeper was ashore for vacation, leaving the two assistants to take care of the stations duties. The First Assistant Keeper was 54-year-old Long Island native Morrell Hulse, a former sailor who had just arrived from two years of duty at the Whale Rock Lighthouse in Rhode Island. The Second Assistant Keeper was a Lighthouse Service rookie named Julius Koster, from New York City.
Newspaper reports state that suddenly and without warning, Koster charged at the other man with a razor tied to the end of a pole. Completely surprised, Hulse managed to fight him off, and Koster seemed to calm down for the time being. But similar events reoccurred over the next few days, forcing Hulse to resist falling asleep at any time. Besides fearing for his life and being on the constant lookout for attacks, he had to keep the light going. This went on for five harrowing days, culminating when Hulse found Koster in the lantern room preparing to destroy the lens with an axe. Somehow Hulse prevented the destructive act.
Kosters moods became increasingly suicidal, and when help finally arrived he had a number of self-inflicted wounds on his body. He was returned to his New York City home, where he soon was successful in his suicide attempts. Later keepers at Stratford Shoal reported disturbances at the station that they blamed on Kosters ghost, including doors slamming by themselves, chairs being thrown around, and pots of hot water jumping from the stove.
The original beacon was a fourth-order Fresnel lens showing a flashing white light and powered by a clockwork mechanism. In 1894, a new Fresnel lens powered by a kerosene lamp was installed, and in 1978 the light source was converted to electric with a wet battery supplying the necessary current. The Fresnel lens has been removed and solar-powered batteries run the current aerobeacon. The station was automated in 1970, and much of the interior detailing has been taken out since then. The Stratford Shoal Lighthouse can be seen from a distance aboard the Bridgeport-Port Jefferson ferry.
Head Keepers: Lewis J. Allen (at least 1940).
Located in the middle of Long Island Sound,
over eight miles offshore from Bridgeport
Harbor. The lighthouse is owned by the Coast Guard. Dwelling/tower closed.
The lighthouse is owned by the Coast Guard. Dwelling/tower closed.
Pictures on this page copyright Kraig Anderson, used by permission.


text:
New Music: Nicki Minaj – 'Starships'
Nicki Minaj proved she can still pack a punch with "Stupid Hoe," and now she pleases her pop fans with her crossover single "Starships." The Harajuku Barbie blasts off with super-producer RedOne (Lady Gaga, Jennifer Lopez) on the radio-friendly record, which will appear on her sophomore album Pink Friday: Roman Reloaded, due April 3.
"Starships were meant to fly/ Hands up and touch the sky/ Can't stop 'cause we're so high/ Let's do this one more time," she sings on the infectious party anthem, which features a brief sample of "Twinkle Twinkle Little Star."
An excited Nicki spoke about the song in an interview with Ryan Seacrest. "'Starships' is one of my absolute, absolute favorite records on Pink Friday: Roman Reloaded," she said. "It makes people feel happy and that's all I want. I want to start the year off with making people feel good."
What do you think of "Starships"? Let us know!Tweet
You can leave a response, or trackback from your own site.
313 Comments
Leave a Reply
©Copyright 2014 Rap-Up.com. Rap-Up® is a registered trademark. All rights reserved.
A Member of Townsquare Music | Advertise


text:
Campus to open Monday
Oregon State University in Corvallis will resume normal operations on Monday, Feb. 10, following significant snowfall accumulations and freezing rain over the past four days in Corvallis and surrounding communities. Due to remaining snow and slushy conditions, travel to and on campus may take longer than expected. Caution should be exercised at all times. The university encourages all concerned to be flexible in permitting reasonable tardiness for work or classes resulting from weather-related travel delays. Updates on OSU operations in Corvalliswill continue to be provided on the university website atoregonstate.edu or by calling 541-737-8000. Notifications via social media are through Twitter athttps://twitter.com/oregonstateuniv and Facebook athttps://www.facebook.com/osubeavers


text:
Manx Shearwater
Puffinus puffinus
- Shearwaters, Fulmars, Petrels
- Procellariiformes
- Pardel pichoneta
- Puffin des anglais
Once a rare visitor to North America, the Manx Shearwater has recently established small populations here. This nocturnal, burrow-nesting bird is an excellent flier—its stiff, rapid wing strokes are followed by the shearing glides low over the water that characterizes this species. The Manx Shearwater became known as the first bird to demonstrate long-range homing abilities, when adults taken from their burrows in Wales performed the 5,150-kilometer journey back home from Boston in only 12 days.
Appearance DescriptionManx Shearwaters average 13.5 inches in length, with a wingspan of 33 inches, and a weight of one pound. This medium-sized shearwater is dark above and pale below, with white under-tail coverts extending almost to the tip of the short tail. It is distinguishable from other shearwaters by a pale crescent behind the ears. Black extends from the bill to cover the eye and auricular openings.
Range DistributionAlthough this shearwater breeds locally in Newfoundland and rarely south to Massachusetts, most of the population breeds in the British Isles. The primary breeding range includes the Westmann Islands in Iceland, the Faeroe Islands, Great Britain, Ireland, France, the Azores, Madeira, and the Canary Islands. Middle Lawn Island in Newfoundland contains the largest North American breeding colony.
HabitatOff North America, Manx Shearwaters generally occur over cooler water. They often feed close to shore, and nest mostly on small islands near the mainland. While the Manx prefers cold water, the very similar Audubon's Shearwater prefers warm water.
FeedingThe Manx Shearwater forages by diving into water from low flight, making shallow dives from the surface, or seizing prey at the surface, or just below, then utilizing its ability to swim underwater. It feeds on a variety of common small fish, including herrings, sardines, and sand lance. Squid and crustaceans are also consumed. Adults seem to be attracted to small fishing boats. They may forage as far as 600 miles from their nesting grounds, returning at night.
ReproductionThe birds nest in dense, nocturnally active island colonies. Five year old Manx Shearwaters may begin breeding, and typically mate for life. The pair digs a burrow up to six feet in length, which they may reuse the following year. The nest chamber at the end of the burrow is lined with plant material. The pair spends significant amounts of time in the nest for several weeks before the single white egg is laid. Both parents incubate the egg for up to two months, and feed the chick for another two months, before finally abandoning it. The chick leaves the nest a little over a week later, heading off to sea alone.
MigrationThe breeding season off northeastern North America lasts from May to October. Many shearwaters begin to move north in early spring. European colonies tend to winter off the east coast of South America. Banding studies have shown that British breeders typically winter in the seas off Brazil, although some individuals may wander further afield. There is evidence of increasing numbers wintering in the Magellan Straits.
- 550,000
- 540
Population Status TrendsManx Shearwaters—particularly the larger, protected European colonies—have recently experienced moderate increases. A surplus of potential breeders from Europe may have contributed to range expansion and the establishment of North American colonies. Manx Shearwaters were found nesting in Massachusetts in 1973 (but not since) and nesting attempts are made annually at Matinicus Rock, Maine and more are being reported off the North Carolina coast. However, during the last several centuries, declines have occurred at some North Atlantic colonies. CBC data also show declines.
Conservation IssuesDuring the 1600s, Manx Shearwaters were harvested extensively in Europe; fledglings were extracted from burrows with iron hooks, killed, salted, and barreled for later boiling. Historically, the birds were also used for lighting-oil in lamps, ploughed into soil as fertilizer, and caught for use as lobster bait. Passage of the Wild Birds Protection Act of 1880 in Great Britain eliminated these practices; to a lesser extent, chicks are still hunted for food in Iceland, the Faeroes, and the Balearics.
Manx shearwaters in Scotland have been found to contain organochlorines from pesticides. Heavy metals recorded in shearwater tissue include zinc, cadmium, and mercury. Manx and related shearwaters are highly prone to crashing into structures after being blinded by bright lights. Some drown via entanglement in sardine fishery nets in the Bay of Biscay. On some larger offshore breeding islands in Europe, overgrazing and the resulting erosion has limited available habitat, restricting nesting to cliffs and other inaccessible sites. Introduced animals have been implicated in reducing or eliminating shearwater populations, including pigs in Bermuda, feral cats in Iceland, and rats on the Isle of Man. Burrows may collapse, and incubating shearwaters may desert, after nest inspections by researchers, particularly if frequent.
Due to intense competition for suitable nest sites, the availability of dry, smooth burrow sites is an important factor in shearwater population expansion and breeding success. Population reduction may arise from burrow competition. Shearwaters take readily to artificial burrows; wooden burrows have been used in Newfoundland colonies where natural burrows are in short supply.
Transplanting shearwater chicks to unoccupied islands, with subsequent broadcasting of calling shearwater recordings to attract returnees, has been attempted in Great Britain, with still uncertain results. Abandoning grazing has aided shearwater recovery at several colonies in Great Britain. Gull control has also resulted in lowered shearwater mortality. The shielding of strong white lights, coupled with their replacement by subdued colored lights, and intense rescue efforts for disoriented shearwaters, are effective strategies for mitigating disorientation.
What You Can DoNever let balloons drift off; shearwaters can become entangled in the strings, and marine mammals can mistake the balloons for food.
Join beach cleanups in your area. Properly discarding of debris, particularly plastic, will prevent shearwaters and other seabirds from eating it.
Make environmentally-friendly seafood choices, which helps protect the marine life that Manx Shearwaters and other seabirds depend upon. Learn more at http://seafood.audubon.org/ or http://www.mbayaq.org/cr/seafoodwatch.asp
Reduce your use of fossil fuels and don't discard used oil into city sewers or municipal water supplies. Transporting fuel inevitably results in oil spills, which can end up in the ocean where shearwaters rest and feed; if their feathers become oiled, the birds are no longer waterproof and cannot survive.
Cut up monofilament fishing line, which can entangle seabirds, prior to discarding it.
Find out about actions you can take including Audubon programs and activities.
More Information
Learn more about international seabird conservation efforts at the North American Bird Conservation Initiative, and the North American Waterbird Initiative .
Learn about ocean conservation at http://www.livingoceans.org/index.shtml
Learn more about this species and other birds through these resources.
Natural History ReferencesKaufman, Kenn. Lives of North American Birds. Houghton Mifflin Company, New York, 1996
Lee, D. S., and J. C. Haney. 1996. Manx Shearwater (Puffinus puffinus). In The Birds of North America, No. 257 (A. Poole and F. Gill, Eds.). The Academy of Natural Sciences, Philadelphia, PA, and The American Ornithologists' Union, Washington, D.C.
Sibley, David Allen. The Sibley Guide to Birds. Alfred A. Knopf, Inc., New York, 2000
Conservation Status ReferencesKaufman, Kenn. Lives of North American Birds. Houghton Mifflin Company, New York, 1996
Lee, D. S., and J. C. Haney. 1996. Manx Shearwater (Puffinus puffinus). In The Birds of North America, No. 257 (A. Poole and F. Gill, Eds.). The Academy of Natural Sciences, Philadelphia, PA, and The American Ornithologists' Union, Washington, D.C.
Sibley, David Allen. The Sibley Guide to Birds. Alfred A. Knopf, Inc., New York, 2000