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Jay Angoff, who returns to Mehri & Skalet after three years with the U.S. Department of Health and Human Services, has devoted his career to protecting the rights of consumers and holding insurance companies accountable. The only person to have served as the lead federal health insurance regulator, the Director of an HHS Region, and a state Insurance Commissioner, he is one of the nation's leading insurance experts.
In March 2010, Mr. Angoff was appointed by HHS Secretary Kathleen Sebelius as the first Director of the HHS Office of Consumer Information and Insurance Oversight—the office responsible for implementing the insurance reform provisions of President Obama's signature legislation, the Affordable Care Act. In that capacity, Mr. Angoff was responsible for the Patient's Bill of Rights, which enables young adults to stay on their parents' policies until age 26; prevents insurance companies from rescinding coverage or cutting off coverage at a numerical lifetime limit; and prohibits insurers from imposing deductibles or co-payments for common preventive services. He was also responsible for implementing the new provision that requires insurers to refund money to policyholders if they spend more than 20% of premiums collected on administrative expenses and profit. This regulation, known as the Medical Loss Ratio or MLR rule, has forced insurers to return more than $1.1 billion to their policyholders in 2011 alone.
Mr. Angoff also oversaw the HHS unit implementing the Exchanges–websites coming on line in 2014 at which people will be able to obtain rate quotes and buy from multiple insurance companies selling four different levels of coverage.
In addition, Mr. Angoff served at HHS as the Senior Advisor to the Secretary and as Regional Director of HHS Region VII, headquartered in Kansas City.
Before serving at HHS Mr. Angoff was in private practice, first in Jefferson City, MO and most recently in Washington, DC with Mehri & Skalet, PLLC where he focused on obtaining refunds for individuals who were overcharged by insurance companies. Class actions in which Mr. Angoff served as counsel include Landers v. Inter-insurance Exchange of the Automobile Club (Los Angeles County, Cal., $24 million settlement), Clutts v. Allstate (Madison County, Ill., $6 million settlement), and Foundation for Taxpayer and Consumer Rights v. GEICO (Los Angeles County, Cal., settlement valued at up to $12 million). He has also represented individuals before state insurance departments, and has consulted for and advised governmental entities, consumer groups, the plaintiff's bar, and other interest groups.
Mr. Angoff is also an expert on non-profit to for-profit conversions. As Missouri Insurance Commissioner he won a five-year legal battle with Blue Cross of Missouri, after which Blue Cross agreed to fund a new healthcare foundation, now one of the nation's largest. In private practice, Mr. Angoff has been retained by various state Insurance Departments faced with proposed Blue Cross transactions and has analyzed and opined on the reasonableness of the Blues' executive compensation. He has also been an expert on charitable trusts, fiduciary duties, antitrust implications and other issues relevant to conversions and other insurance transactions.
Mr. Angoff has advocated for managed competition and successfully implemented systemic reforms. As Missouri Insurance Commissioner and a Director of the Missouri state health plan, Mr. Angoff required insurers to submit competitive bids for a single standardized benefit package. As a result, rates fell by up to 45%.
Prior to serving in Missouri, Mr. Angoff was Deputy Insurance Commissioner of New Jersey and Special Assistant for Health Insurance Policy to New Jersey Governor Jim Florio. In those positions, he played a major role in drafting and implementing New Jersey's individual and small group community rating law.
In 1988 Mr. Angoff helped draft and served as a consultant to the campaign supporting California's Proposition 103, a ballot initiative which rolled back auto insurance rates. The following year he chaired the New Jersey Citizens Auto Revolt campaign to put an initiative on the ballot cutting auto insurance costs. That proposal is still the only initiative to qualify for the ballot in all 21 New Jersey counties.
Mr. Angoff began his career as an antitrust lawyer with the Federal Trade Commission. He also served as a staff attorney for Congress Watch, a public interest lobbying organization, and as counsel to the National Insurance Consumer Organization. He has written for The New York Times, The Washington Post, and The Wall Street Journal, among other publications. He is a member of the District of Columbia, Missouri, New Jersey, and U.S. Supreme Court bars, and is a graduate of Oberlin College and Vanderbilt Law School.


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Make your next business meeting or social event a true delight, with our award-winning and affordable catering menu. Our Southern California Catering offers a plethora of savory American cuisine to match any budget and any size event. Please call 800.589.RIBS or 805.719.9000 ext. 1 to speak with one of our catering coordinators or click here for additional catering information.
Experienced catering staff will work closely with you to create a memorable event for you and your guests, anywhere throughout South California.
Catering Services: Full Service Catering Company, Flexible & Budget-Friendly Southern California Caterers
From "Full Service & Grill on Site" options, to simply picking up your order using our convenient Tailgate Setup, our catering service is outstandingly flexible. We provide catering services seven days a week, 24 hours a day! As one of the finest catering companies in Southern California, we offer remarkably delicious and beautifully presented catering menus, perfect for corporate catering, wedding catering, as well as, any other social event catering.
We are award-winning Southern California caterers! Catering fun parties is our badge of distinction! We'd love the opportunity to cater your next special event, large or small, from 10 to 10,000 guests. As a catering company acclaimed for its excellence, we promise that your event will be well-planned and organized from start to finish and that we will delight you with delicious and plentiful food.
Catering: Large Parties, Event Catering
In addition to our off-premise catering services, we often cater large parties and events in-house. Please call the restaurant directly and ask to speak with a manager. Discover how our celebrated catering service will allow you to be a delighted guest at your own party. When it comes to corporate catering, large party catering and event catering, we are second to none!
We Cater Southern California
Corporate events, birthday parties, anniversaries, social events, weddings, baby showers, bridal showers, receptions, and any other special celebrations in South California will sparkle and delight with our fabulous food, impeccable service, and great prices.
CATERING AWARDS and ACCOLADES
"Best of CITYSEARCH" - First Place Award for: American Food, Barbeque, Steak, Family-Friendly, Lunch, Catering Company, and Group Dining.
"Best barbecue, Best Caterer, Best Take-Out" Conejo Valley TODAY Magazine Readers' Choice Awards
"Best Barbecue," The Los Angeles Daily News
"BBQ King." L.A. Weekly
"Wood Ranch is ecstacy!" Merrill Shindler, KABC Radio

subset: commoncrawl


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Marvel Creativity Studio Stylus And App (Photo: Business Wire)
Disney Consumer Products (DCP) and Marvel Entertainment today announced the launch of the Marvel Creativity Studio Stylus and App, created by eKids, exclusively for iPad. The app delivers a creative space for kids to learn to draw, color and animate their favorite Marvel Super Heroes and villains from Avengers Assemble, The Ultimate Spider-Man and Hulk and the Agents of S.M.A.S.H., while the stylus adds special and enhanced play value.
Marvel Creativity Studio Stylus and App (Photo: Business Wire)
"The Marvel Creativity Studio is an innovative way for fans of all ages to learn how to draw some of Marvel's most popular Super Heroes while allowing them to use their imagination to feel like they're part of the action," said Josh Silverman, executive vice president of global franchise licensing and commercialization at Disney Consumer Products. "Leveraging the comic drawing history of the Marvel brand with the innovation that eKids brings to the table – or in this case, tablet – this product delivers a fun experience with endless play value."
App and Stylus features include:
- Professionally illustrated coloring pages, where you can add your own flare with tons of drawing tools and an extensive color pallet
- Use of the stylus to unlock special tools including the " Reveal" tool to flawlessly color the page like a pro
- An interactive grid system that includes specialty drawing aids such as side-by-side drawing canvas, trace lines and unique "Drawing Scope" – allowing artists of all levels to successfully learn how to draw these characters
- Build and animate action scenes with character stickers, sound effects, speech bubbles and backgrounds
- Create your own custom stickers and add them to animated scenes
In addition to the launch of the Marvel Creativity Studio Stylus and App, the Disney Creativity Studio App has received a content refresh with more drawing tools to use, so kids can now create drawings of even more of their favorite Disney characters including Disney Junior's Sofia the First, Doc McStuffins and Jake and the Never Land Pirates, as well as Monsters University and Disney Princess characters.
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Our Exhibits
The Museum's exhibits are carefully designed to nurture children's imaginations, build their confidence and competence, and encourage them to test, tinker, laugh, create, and wonder!
All of our exhibits and programs are aligned to meet the California state curriculum standards, and are accessible for individuals with developmental, hearing, physical, social/emotional and visual challenges.
All of our exhibits and programs are aligned to meet the California state curriculum standards, and are accessible for individuals with developmental, hearing, physical, social/emotional and visual challenges.
Story Factory
This literacy-focused exhibit serves as a platform to carry out both structured literacy programs and activities and general reading and literacy exploration for our visitors! This exhibit is made possible by a generous grant from the RCA Community Fund.
Water is all around us! We bathe in it, squirt it at friends, fill balloons with it, swim through it, and even grow sea monkeys in it.
In this exhibit, children can experiment with the flow of water, build their own boat, create whirlpools, and more. You will get wet!
Ships Ahoy!
The SS Leo has docked in the SCM harbor! Use your imagination to set sail in Waterways.
Leo's Market and Farmer's Market
Sort fruits and vegetables, stock shelves, help others checkout at the cash register while playing in this child sized market.
This exhibit offers children a fun, role-playing experience, as well as, helps them develop knowledge about nutrition, sorting, measuring, counting, and cooperation. Items in the super market will include foods grown locally, as well as, foods from around the world.
Airways and Raceways
Have a ball playing with velocity, gravity, motion, friction, and acceleration. In Raceways visitors will understand such mysteries as why people don't fall out of a rollercoaster when riding upside down.
This exhibit demonstrates basic principles of objects in motion that were formulated by Sir Isaac Newton and Galileo Galilei.
Baby Bloomers
This space is separated from the rest of the exhibits and is specially designed for babies and toddlers to enjoy safe exploration.
Young children can walk up carefully sized steps, play peek-a-boo, dress-up like a farm animal, plant a flower or even explore the realm of physical knowledge by rolling and kicking.
Studio of the Arts
Prepare to get messy! The art studio provides opportunities for self-expression and creativity. Join us for three activities each month! Become part of the SCM community by adding color to the glass paint wall, create something from recycled, reusable, donated materials at ReCreation Station or participate in our monthly Art Studio Activity.
Children are allowed and encouraged to express themselves, leaving them with a feeling of satisfaction and accomplishment and supports the notion that art can be anything you want it to be.


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With more than 11,000 rooms for rent in the Black Hills and Badlands, visitors can find lodging facilities that range from a rustic cabin in the woods to nationally-recognized 5-star accommodations featuring swimming pools, on-site restaurants and gyms, shuttle service and every imaginable amenity.
Stay at a cozy bed and breakfast tucked alongside a country road, or rent a vacation home to give your family that "home away from home" feeling. You'll find popular hotel and motel chains in almost every community. Stay at a Best Western or relax at a Comfort Inn, Days Inn, Holiday Inn or other recognized name. We've got them all, and they'll leave the light on for you. Several hotels and resorts feature water slides or sprawling indoor water parks.
Stay at a dude ranch to get a real taste of Western life, or experience the Old West in a rustic cabin. Luxury cabins and everything in between are also available.
The following pages list available lodging opportunities.
Bed and Breakfasts
Dude Ranches
Hotels and Motels
Vacation Homes


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Romans love to eat. And they love to eat good food. Despite their easy-going whatever happens, happens attitude, they can become really picky when it comes to food.
The city centre has obviously the highest concentration of tourists so it can quite easy to fall into the tourist traps but if you see a restaurant packed with locals, go for it, as you cant be wrong.
Most likely, it will be a good place.
In Rome, youll find out that Italians are more than just pasta and pizza.
The hundreds and hundreds of restaurants of this city will delight you with all kind of gastronomic specialties:
from the food of Romes tradition to dishes from the different regions of Italy to exotic menu from all around the globe.
There are possibilities for every pocket and for every mood. There are hip spots that attract a fashionable crowds, haute cuisine restaurants, countless pizzerias, those popular eateries called trattorie,
where it is not hard to find an old mama(no, it is not only a stereotype, I have stepped into a couple of those myself!) making fresh hand made pasta or even wine bars where you can nibble while enjoying a glass of wine.
Da Lucia, via del Mattonato 2B, Phone: 06/580301
location area: Trastevere
Opened in 1938, this rustic, family run trattoria serves generous servings of traditional home made Roman cuisine such as Roman style gnocchi and cuttlefish with snow peas
Agata e Romeo, via c. Alberto 45, Phone: 06/4466115
area: Esquilino
A little pricey and elegant, it brings Roman cuisine to the next level: Roman dishes with a bit of an edge, mixing tradition with some creativity. Good wine list.
Giggetto, Via del Portico DOttavia 21/9, Phone: 06/6861105
area: Jewish Ghetto
Set in the Old Jewish Ghetto, only steps away from the Portico D Ottavia and the Synagogue, it is well
renowed for its Roman- jewish dishes.
Checco er Carettiere, via Benedetta 10, Phone: 5817018
area: Trastevere
It is located in the heart of Trastevere district, one of the most characteristic Roman area . It is great for a full immersion in the roman gastronomic culture and true to tradition dishes.
Alfredo ed Ada, Via dei Banchi nuovi 14, Phone:066878842
area: Piazza Navona/ Campo de Fiori
Tiny cozy Rome restaurant is active since 60 years. Tables with paper cloths and a honest menu unchanged in time: amatriciana, carbonara, meat balls with tomato sauce and house wines
Sora Margherita, piazza delle Cinque Scole 30, Phone: 06/6874216
area: Jewish Ghetto
In the heart of the Ghetto, this is the place for people who look for authentic atmosphere and good food. Everything screams Rome here and the Roman-jewish tradition is everywhere: in the pasta soups( with chickpeas, with lentils, with skater or beans), in the second courses, in the desserts.
Armando al Pantheon, Salita Dei Crescenzi 31, Phone: 06/68803034
area: Pantheon
A very welcoming restaurant, whose menu offers many delights such as different kinds of bruschetta and a great selection of second courses and vegetable alla romana.
La Gensola, piazza Gensola 5, Phone: 06/58332758
area: Trastevere
In this fish Rome's restaurant of old tradition, located in a XV th century palazzo, you can savour pasta dishes with sea-urchin, grilled cod with tomato sauce and tuna fish.
Riccioli Cafe, piazza delle Coppelle 10/a
area: Pantheon
Sea food heaven in a high tech atmosphere. Also sushi and oyster bar with international wines list.
Alberto Ciarla, piazza San Cosimato 40, Phone: 06/5818668
area: Trastevere
Be prepared to pay a bit more than usual here but you ll be rewarded with one of the best restaurant in town. The high quality of ingredients and the excellent proposals will definitely please your senses
Akropolis, via San Francesco a Ripa 103, Phone: 06/5833260
area: Trastevere
In a non formal and casual ambience, you can enjoy real greek recipes such as moussaka , spanakopita, wine.
leaves and much more. Open only evenings
Franz, via di Porta Castello 23/24, Phone: 06/6873921
area: Vatican/ Castel San Angelo
Fancy a bavarian snack after a long day spent around the Vatican area? This is the place for you. Dig into a
Bavarian and Austrian feast with their goulash, knodel and luscious desserts like sacher torte.
Mahrajah, via dei Serpenti 124, Phone: 06/4747144
area: Monti
Cozy and quiete even when crowded, it has a very rich menu that includes many northern Indian specials.
Very attentive service.
Doozo Art Books and Sushi, via Palermo 51/53, Phone: 06. 4815655
area: Monti
Here you can have fresh sushi and sashimi while taking a look at their photography and contemporary art
Sciam, via del Pellegrino 55, Phone: 06/68308957
area: Campo De Fiori
You can come here until late at night to enjoy an Arabian night, nibbling on middle eastern courses and
surrounded by candlelight.
Ketumbar, via Glavani 24, Phone: 06/57305338
area: Testaccio
Come here to see and be seen. Local celebrities and Rome soccer players have been spotted here in this sophisticated, minimalist restaurant of Rome where you can try Mediterranean but also fusion courses and sushi and listen to chill out music.
Panattoni, viale Trastevere 53/57, Phone: 06/5800919
area: Trastevere
This place is an institution in Rome. Dont expect anything formal here and be prepared to wait before
you ll find a table but the pizza here is authentic (thin and crunchy) and the offer of fried appetizers is worth
being squeezed between strangers.
Gusto, piazza Augusto Imperatore 9, Phone: 06/3226273
area: via del Corso/ Babuino
This multifunctional space is a very famous address in town. It is a pizzeria but also a restaurant and a wine bar where you can even buy design kitchen tools and precious wines.
Acchiappafantasmi, via dei Cappellari 66, Phone: 06/6873462
area: Campo De Fiori
Many kind of pizza(and toppings) in a ghost shape(after all, the name of this pizzeria means Ghostbusters) and a rich offer of Mediterranean and spicy dishes from the southern Calabria region
Brasia, vicolo delle Grotte 17, Phone: 06/97277119
area: Campo De Fiori
Simple but quite elegant pizzeria and restaurant with several proposals on its menu. Crunchy, crispy roman pizza cooked in wood oven but also grilled meat, pasta and appetizers
Margutta ristorante, via Margutta 18, Phone: 06/32650577
area: Piazza Del Popolo
Well known and refined Rome's restaurant famous for its vegetarian dishes such as cheese ravioli and fava beans soufflé.
Arancia Blu, via dei Latini 55/65, Phone: 06/4454105
area: San Lorenzo area
A bit out of the centre of Rome but located in the lively University area (San Lorenzo), it offers vegetable lasagne, delicious quiches and an interesting wine list.
Alfredo alla Scrofa, via della Scrofa 104/a, Phone: 06/68806163
area: San Eustachio area
Have you ever wondered where the legend of the famous Fettuccine Alfredo started? Right here, since 1907. Beside this worldwide known dish, you can also have here eggplant parmigiana, fish and meat and a tiramisu to finish off your meal.
Capricci Siciliani, via di Panico 83, Phone: 06/45433823
area: Castel San Angelo
Cross the San Angelo Bridge and youll find a little piece of Sicily in the heart of Rome and all the best delicacies of this beautiful island. Let yourself be tempted by their Pasta alla Norma, swordfish roulade, cassata and cannoli
Alfredo al Campidoglio, via dei Fienili 56, Phone: 06/69191024
area: Campidoglio
Overlooking the Campidoglio Hill, this is a place that will welcome you after a long day wandering around the nearby archeological sites. Great selection of cheeses and cold cuts, pasta dishes cooked with a sometimes creative touch and truffle specialties.
La Pentolaccia, via Flavia 38, Phone: 06/483477
area: Via Veneto
Located near Via Veneto and the american Embassy, it is an elegant address( but with good prices) and it has a gastronomic repertoire based on traditional, Italian cuisine. Try their ravioli with mozzarella di bufala while sipping on one of the Italian wines on their list.
Supper Club,via De Nari 14, 06/68301011
area: Pantheon
Warning: this is not a traditional restaurant at all. You can come here to enjoy the amazing, unusual and sometimes cosmopolitan atmosphere and the bare-chested waiters who will serve you creative superb food while you will be seated on snow white lounge sofas while listening to dj sets and enjoying art performance. Booking is essential.
Santa Lucia, Largo Febo 12, Phone: 06/68802427
area: Piazza Navona
Romantic location( it has also some tables outside) for this restaurant that is also a destination for many cinema stars once they are in Rome. Not without a reason: the food here, inspired by Naples and Campania region, is excellent and inspite the show biz guests that may appear here from time to time, the atmosphere is relaxing.
Trimani, via Goito 20, Phone: 06/4469661
area: Termini Station area
A wine temple. Gourmet specialties sold and served here but above all, wines from all over Italy and the world.


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Posted: Friday, March 28th 2014 at 8:42am
New development near Savannah expected to create 10,000+ jobs
By The Associated Press
HARDEEVILLE, S.C. (AP) -- A large new development on the South Carolina side of the Savannah River near Savannah is expected to mean thousands of jobs for Jasper County.
The Island Packet of Hilton Head reports (http://bit.ly/1hhsZIR ) ground was broken Thursday on the 5,000-acre development called Riverport that borders both the river and Interstate 95.
The project is joint public-private development. Developers expect it will attract $875 million in investment and create more than 10,000 new jobs.
Riverport will include a 170-acre industrial park as well as additional space for distribution and warehouse facilities. There also are plans for a retail shopping district, homes, schools and a public safety building.
The property is next to the site where South Carolina and Georgia are working to build a new container ship terminal.
Associated Categories: Homepage, National News, Business News, Local/State News
© Copyright 2014 AccessNorthGa.com
All rights reserved. This material may not be published, broadcast, rewritten, or redistributed without permission.


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We are here for all your auto parts needs. Don't let other sites fool you, AutohausAZ has the best quality and best price on Suzuki X90 Brake Pads parts. Most of our Suzuki X90 Brake Pads parts orders will ship out within 1 business day when you make sure to place your order by 1 pm MST. Our secure online payment system is much safer than using your credit card at your local retailer. Besides offering the lowest prices on the web, our customer service is second to none. Our web store makes it possible to order your Suzuki X90 Brake Pads parts at two in the morning while in your pajamas. We have staff dedicated to helping you order Suzuki X90 Brake Pads parts from our website. Stop searching the internet, you have come to the best place for auto parts on the net.
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text: The Craft Beer Thread Jun 19, 2013 2:08:15 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by Rusty on Jun 19, 2013 2:08:15 GMT -5 Found a great beer store near my new place , and finally tried some of the beers you guys always talk about. I bought this one on a whim because of the name:It's Hoparazzi - by Parallel if you couldn't tell. Has any one else had this...I kind of assumed it was an IPA based on the name, but it turned out to be a hoppy lager...or "India Pale Lager". I really enjoyed it as a "lighter" form of an IPA, thoughts?


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Banking and Finance
Banking and Financial Services
Plot 4, Parliament Avenue
P.O. box:7368, Kampala
+256 4177 00 100/
0312 354 100
At Ecobank Corporate Banking, we know that business success depends on much more than just access to money. We understand the broader needs of enterprises, be they multinationals or entrepreneurial start-ups. Our unrivalled presence across Africa and our experience of helping businesses grow means that we can provide you with practical financing solutions and ongoing support.
It is the knowledge, experience and local insight of our people that distinguishes Ecobank from our rivals and we place their considerable expertise at your disposal. At the heart of our involvement is your dedicated pan-African Relationship Manager who is committed to understanding your business needs and providing responsive, customized lending solutions, with a focus on local empowerment.
Whether you are in need of a trade loan, working capital or longer-term project finance, we are uniquely positioned to deliver a truly pan-African service:
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P.O. box:7368, Kampala
Phone:( 256) 4177 00 100/0312 354 100
Fax:(256) 312 266 079
Houses for Sale Uganda-Looking for Apartments & Houses to buy or sell Kampala Uganda
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Ugandan Souvenirs, Home Decor items, Picture Framing materials, Art & Craft Supplies Direct to your Door


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Dr. David Mattson
Dr. Herman Karl
January IAP 2007
For the last century, precepts of scientific management and administrative rationality have concentrated power in the hands of technical specialists, which in recent decades has contributed to widespread disenfranchisement and discontent among stakeholders in natural resources cases. In this seminar we examine the limitations of scientific management as a model both for governance and for gathering and using information, and describe alternative methods for informing and organizing decision-making processes. We feature cases involving large carnivores in the West (mountain lions and grizzly bears), Northeast coastal fisheries, and adaptive management of the Colorado River. There will be nightly readings and a short written assignment.
Mattson, David, and Herman Karl. 11.959 Reforming Natural Resources Governance: Failings of Scientific Rationalism and Alternatives for Building Common Ground, January IAP 2007. (MIT OpenCourseWare: Massachusetts Institute of Technology), http://ocw.mit.edu/courses/urban-studies-and-planning/11-959-reforming-natural-resources-governance-failings-of-scientific-rationalism-and-alternatives-for-building-common-ground-january-iap-2007 (Accessed). License: Creative Commons BY-NC-SA
For more information about using these materials and the Creative Commons license, see our Terms of Use.


text:
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text:
Tag Archives: Spain
Type 2 Diabetes Opportunities in Europe "Vast", Says Report
By Pharm Exec | Published: February 11, 2014
"Vast" Diabetes Opportunities in Europe, Says Report The European type 2 diabetes market earned revenues of €9.50 billion in 2009 and is estimated to reach €15.46 billion in 2017 (CAGR 3.8 percent), according to new research by Frost & Sullivan. The International Diabetes Federation states that more than 55 million people have been diagnosed with […]
Posted in Europe, healthcare | Also tagged Europe, Finland, Germany, Italy, Norway, Sweden, Type 2 diabetes, UK | Leave a comment
Orphan Drug Adoption: the More Regulation, the Better
By Clark Herman | Published: July 29, 2013
New survey research indicates that a country with a strong regulatory commitment for advancing drugs for rare diseases does better in getting orphan drugs to patients than countries with lesser regulatory frameworks. In his study, 'The Effect of Market-Based Economic Factors on the Adoption of Orphan Drugs Across Multiple Countries,' John Matthews, Associate Director of […]
Posted in Europe, Global, Market Access, Orphan Drugs, pricing, Regulatory | Also tagged economy, France, Germany, UK, US, World Economic Freedoms Index | Leave a comment
Spanish Generics Industry to Government: "Leave Branded Pharma Alone"
By Guest Blogger | Published: October 24, 2012
Just days before the reports that R&D investment in Spanish pharma had fallen to below EUR1 billion ($1.3 billion) in 2011 for the first time since 2007, the country's generic manufacturers association, AESEG, offered some unexpected support for the branded industry. In comments to APM Health Europe described as "rare", AESEG chief Ángel Luis Rodríguez […]
Posted in Europe, Global, healthcare | Also tagged AESEG, Angel Luis Rodriguez de la Cuerda, Cuts, eurozone, Faramindustria, generics | Leave a comment
The Pain in Spain
By Guest Blogger | Published: February 16, 2011
The pain of the Spanish drug-spending squeeze extends way beyond the plain, says Reflector. The cries of anguish at Spanish drug-spending squeezes are coming not only from Madrid, but from many of the autonomous regions around the periphery of the country too. After almost a decade of continual disruption and downward pressure on pricing, the […]
Posted in Europe, Global, Guest Blog, Regulatory | Also tagged Cuts, generics, reference pricing | 2 Comments
Europe's Fiscal Crisis: Can Big Pharma Emerge Unscathed?
By William Looney | Published: June 2, 2010
Europe's current fiscal crisis, symbolized by the meltdown in Greece, is seen by big pharma as a temporary situation to be taken in stride—after all, the EU southern and eastern tier, with its chronically shaky finances and per capita incomes as low as a third of the EU norm, has historically been a marginal player […]
Posted in Europe | Also tagged Andrew Witty, Drug Prices, Europe, Financial Crisis, Greece, GSK | 2 Comments


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Local chef cooks up creative Super Bowl eats
Updated On: Feb 03 2013 08:22:40 AM EST
Forget the chips and dip and chicken wings this year. A local chef shared her take on Super Bowl Sunday snacks with News 8's Norm Karkos.
Nancy Cerny, who co-owns CVC Catering, will demonstrated several recipes during News 8 This Morning.
Cerny said the key is to prepare the foods before the game in order to enjoy the Super Bowl, while it's on TV.
You can find her recipes right here.
Copyright 2013 by WMTW.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Tizen is no Android, but will still play an important role
Steve Patterson (2850575) writes | about a year and a half ago0
Steve Patterson (2850575) writes "Tizen is clumsily positioned directly against Android and iOS. Its backers — Samsung, Intel, the Linux foundation, and a large community of open source developers with experience competing with and against market-leading OS platforms — are not that naive. Naïveté aside, Tizen can play an important role."
Link to Original Source


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Storm Alert
Humidity 41%
Winds 3.5mph
Humidity 41%
Winds 3.5mph
Oct 3, 2011 2:02 PM
WASHINGTON - The Secretary of Veterans Affairs announced Monday that the Department of Veterans Affairs awarded the Pascua Yaqui Tribe a $322,554 grant to establish the Pascua Yaqui Tribe Veterans Cemetery near Tucson.
This grant will pay for the construction of approximately 350 casket gravesites, landscaping and supporting infrastructure on approximately two acres. The cemetery will provide burial options for approximately 188 Pascua Yaqui Tribe Veterans and their families.
The cemetery will be on the Pascua Yaqui reservation southwest of Tucson. Currently, the closest national cemetery is VA's National Memorial Cemetery of Arizona, in Phoenix. The nearest state Veterans cemetery is the Southern Arizona Veterans Memorial Cemetery in Sierra Vista.
19 hours ago


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You are here: Home : Conservation : Kibale National Park
Ecology of Kibale National Park
Photo by Kevin Langergraber
The North Carolina Zoo has supported the research of Dr. Jeremiah Lwanga in Kibale National Park, Uganda for over five years.
Dr. Lwanga works at the Ngogo research site at Kibale and conducts research on rainforest trees and plants used by chimpanzees and is involved with monitoring the Ngogo chimpanzee population.
Support for Dr. Lwanga comes from the donation box at the NC Zoo chimpanzee exhibit.


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Event Overview
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Who Is T-boz Dating In 2010 Discovery
who is t-boz dating in 2010
May 24, 2012
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.. Plus, theyre shutting down the MIA with live NYE performances. Weve got the deets plus pics of T-Boz and her daughter Chase wrapping gifts ...Jan 8, 2013 ... From Yahoo Music: T-Boz said she and late TLC member Left Eye ... guitar in the band Bad Things with a group of buddies that date back to his .
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.. Now Left Eye is dating a dude named Larry.Nov 25, 2013 ... You are here: Home / Archives for Tionne T-Boz Watkins ... her dates have to treat all of her friends to dinner � in case the date doesnt go well.Top tracks from T-Boz: Touch Myself, My Getaway & more. Watkins was born in Des Moines, Iowa on April 26th, 1970. She is of both African American and ...
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Riding off the success of what was a very big 2011, it's no surprise that Apple is looking to expand its business to new areas of the United States and the world at large. And what better way to do that than to create an Apple campus in the biggest state: Texas.
According to Apple spokesman Steve Dowling,, Apple has experienced tremendous growth in their Austin operations, with more than 3500 Apple employees in Austin today. Now Apple wants to build on this by creating a massive $304 million campus in Austin, Texas, which should add 3,600 more jobs over the next decade. For those keeping score at home, that will double the workforce Apple currently has in the city.
Texas Governor Rick Perry said in a statement that, "investments like this further Texas' potential to become the nation's next high-tech hub." According to Perry's office, the new Apple campus jobs will mostly be in sales, customer support, and accounting–although it's possible that in the future, some of the high tech Apple jobs may come to the Austin campus.
As you might recall from a recent article here about Apple's hinting at Corning glass on the new iPhone 5, Apple has boasted of creating roughly 514,000 jobs throughout the United States–a very impressive number considering the fact that a decade ago, Apple employed a mere fraction of that.
Although the idea of a $304 million campus is impressive even for such a large company as Apple, it's likely that this is just the start of what's to come. With the smash success of the new iPad and the upcoming iPhone 5, Apple may be looking to expand in even more areas in the months and years to come. And who knows, maybe your city or state will be next to play host to the high tech goodness that is Apple.


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The Graziadio Experience
The Graziadio School rejects the impersonal, drive-through approach that too often passes for business education. No student slips through the Graziadio School unchallenged or unnoticed. We pride ourselves on giving students personal attention through small classes, world-class faculty, and a tight-knit community of learners and leaders.
Graziadio Hallmarks
Learn about the values and approach to learning that are uniquely Graziadio.
Life at Pepperdine
Personal attention and community make it more than just a degree.
Exceptional real-world and academic credentials… and they'll know you by name.
Internationally recognized and a prestigious member of the AACSB.
Blogs & Podcasts
Meet and interact with the movers and shakers here at Pepperdine.


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She is famous Katy Perry for a lot of hits like "Teenage Dream", "Firework", "Part of me" and so on. Her dresses on stage are really strange just like her and her music style. Let's discover and play the dress up games
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Things to do in New York City: Spring dance shows
Spring dance showcases some of the best things to do in New York City, from French experimentation to the finest in ballet
Fri Feb 21 2014
CommentsAdd +
If you're looking for things to do in New York City, dance comes to the rescue with dueling Lincoln Center seasons featuring both American Ballet Theatre and New York City Ballet—including the return of Justin Peck's wonderful Year of the Rabbit—as well as Danse: A French-American Festival of Performance and Ideas. It's time for a thaw, and spring dance will be fresher than ever.
Faye Driscoll
Driscoll's Thank You for Coming—created with the performers Giulia Carotenuto, Sean Donovan, Alicia Ohs, Brandon Washington and Nikki Zialcita, and designers Nick Vaughan, Jake Margolin and Amanda K. Ringger—reflects on the experience and event of performance. In the piece, the collaborators draw from dance ritual throughout time and genre, from cultural ceremony to story ballets, all while questioning dances influence and influences, including the role of the audience.
- Danspace Project at St. Mark's Church in-the-Bowery 131 E 10th St, at Second Ave
- Thu Mar 6 - Sat Mar 15
Paul Taylor Dance Company
Taylor is the last living modern-dance legend of the 20th century, and he's still going strong. For his troupe's three-week New York season, the company's transcendent dancers perform two new works, as well as a repertory classics, including rare sightings of Fibers, Private Domain and Dust, and favorites such as Esplanade, Cloven Kingdom and Arden Court. The Mar 13 gala showcases New York City Ballet principals Tiler Peck and Robert Fairchild in an excerpt from Airs. On Mar 23, in celebration of the company's 60th-anniversary season, 47 former Taylor dancers—Carolyn Adams, Ruth Andrien and Bettie de Jong are among the mix—revive 1965's From Sea to Shining Sea; tickets are half price.
- David H. Koch Theater (at Lincoln Center) 20 Lincoln Center Plaza, at 63rd St
- Wed Mar 12 - Sun Mar 30
Martha Graham Dance Company 2014
The queen of modern dance's legacy lives on. This season, the company performs a variety of classic Graham works, including the 70-year-old Appalachian Spring and 30-year-old The Rite of Spring. Highlights also include 1990's Maple Leaf Rag—the last work Graham choreographed—and a new one-act version of Clytemnestra (1958), arranged by artistic director Janet Eilber and former Graham company member Linda Hodes. In a new approach to programming, the company will also perform new works by guest choreographers; this year's artists are Nacho Duato and Andonis Foniadakis.
- New York City Center 131 W 55th St, between Sixth and Seventh Aves
- Wed Mar 19 - Sat Mar 22
New York City Ballet Spring 2014
The company's spring season focuses on 21st-century choreographers, with selections by Mauro Bigonzetti, William Forsythe, Peter Martins, Benjamin Millepied, Justin Peck, Angelin Preljocaj, Alexei Ratmansky, Liam Scarlett, Richard Tanner and Christopher Wheeldon. To balance, entire programs are also dedicated to the choreography of Balanchine and Robbins, including works from the company's 1964 inaugural Lincoln Center season: The Four Temperaments, Raymonda Variations, Symphony in C and A Midsummer Night's Dream.
- David H. Koch Theater (at Lincoln Center) 20 Lincoln Center Plaza, at 63rd St
- Tue Apr 29 - Sun Jun 8
DANSE: A French-American Festival of Performance and Ideas
France invades New York for a three-week festival of performances and talks that also unveils two publications: an anthology of existing writing, and a catalog documenting aspects of the festival. Events take place at venues throughout town, and the artists are a diverse, experimental crew, including Christian Rizzo, Cecilia Bengolea and François Chaignaud, David Wampach, Ashley Chen, Cédric Andrieux, Christophe Ives and Lyon Opera Ballet. Visit the website for details.• frenchculture.org
- La MaMa E.T.C. 74A E 4th St, between Bowery and Second Ave
- Thu May 1 - Sun May 18
American Ballet Theatre Spring 2014
The company—including dancers Roberto Bolle, Herman Cornejo, Marcelo Gomes, David Hallberg, Paloma Herrera, Julie Kent, Gillian Murphy, Veronika Part, Xiomara Reyes, Polina Semionova, Hee Seo, Daniil Simkin, Cory Stearns, Ivan Vasiliev, Diana Vishneva and the newest principal, James Whiteside—returns for its spring season. Highlights include the company premiere of Frederick Ashton's Cinderella, as well as a "Shakespeare Celebration," featuring Ashton's The Dream and Alexei Ratmansky's The Tempest. The lineup also features Leonide Massine's Gaîté Parisienne and Kenneth MacMillan's Manon, and guest performers Alina Cojocaru, Maria Kochetkova and Denis Matvienko.
- Metropolitan Opera House (at Lincoln Center) Lincoln Center Plaza, at 65th St
- Mon May 12 - Sat Jul 5
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Applying for Award of the Master's Degree
Enrollment in a Master's program at SJSU does not mean that you will automatically be awarded a degree. You will need to initiate the process by completing the Application for Award of Master's Degree Form. (Available at the Graduate Studies Website). Please refer to the filing deadlines prior to submission. The deadline for submission of this document usually comes right at the beginning of the semester you plan to graduate, so try and file the form the semester before you expect to graduate. (See the Graduate Studies website for deadlines). Presently, there is no fee with this applicaton if you are a current student, but a $10 one if you are not—a reactivation fee. This form need only be signed by you. You must have candidacy approval from the Graduate Studies Office before this application will be accepted.


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Live updates
Thinking of what might have been
Polish skipper gutted after defeat
Poland captain Jakub Blaszczykowski admitted it was a shame that the host nation had been eliminated at the group stage, but said that the experience of a major tournament would stand his side in good stead for the future.
– Polish captain Jakub Blaszczykowski
The positive thing is that we fought to keep things even in all three matches. It was a great tournament, just a shame that we have gone out so early. In the first half we had several great opportunities which we couldn't put away. After the break we knew that we had to attack more. But the Czechs played on the counter and caught us out with one of them. It's very important that we take away big tournament experience.
No laughing matter
Smuda quits as Poland coach
Poland coach Franciszek Smuda has said he will leave his job following the tournament co-hosts' elimination from Euro 2012. The Poles finished bottom of their group after a 1-0 defeat by neighbours the Czech Republic. "This is 100 per cent the end of the road," Smuda told Polish television.
Peter Cech = Freddie Flintoff
Bye, Pole-ar
Highlights: Czech Rep 1-0 Poland
Petr Jiracek's second-half goal ensured the Czech Republic squeaked into the quarter-finals as co-hosts Poland exitRead the full story
It's a shame that Poland are out, it's always difficult when the host goes. Their support was fantastic and they really don't deserve it.
Polish host in Sopot jumped on to the piano to play the death march within 30 seconds of the match finishing. #EUR02012
"My team are out, it's the end of the world. I wish I was de OH LOOK I'M ON A BIG SCREEN! HELLO! HELLO! HAHAHAHAHA I'M WAVING AT MYSELF!"


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The CIR Is On It: Telling the Story of Solitary Confinement for Teens Over, and Over, and Over Again
This week, the Center for Investigative Reporting released a print story, a short animation, and a photo essay about solitary confinement for adolescents in the U.S. prison system. That's in addition to a NewsHour and a public radio piece released last month and to a yet unreleased half hour documentary and graphic novel. By the end of the month, there will be around 10 pieces of the adolescent solitary confinement story circling you on one form of media or another.
It's enough to make you rethink what you've been reporting on all year. CIR reporters Daffodil Altan and Trey Bundy started over a year ago trying to gain access into prisons and report on conditions for teens. Altan says that the access issues surrounding the story seemed "almost insurmountable" at a certain point. Instead of being deterred, they pressed on and worked on thinking of different ways to handle the content. Says Altan:
We started of thinking of ways to tell the story even though we were dealing with essentially invisible sights. That's where the idea for the animation came up. We had met this very compelling young man in New York who told us about his experience at Rikers very powerfully and we had all this tape of him…we decided to try to take 3 hours of interview and see if we could carve that into something smaller and with a narrative arc.
And so the reporting team of two or three turned into a team of somewhere around 15-20, according to Bundy. Bundy says that as they are reporting they're "always having conversations about what else we can do besides what we've already settled on." In this case, there was a written story in mind, with photos to boot. But a colleague who acts as a liaison between the CIR and KQED "heard radio all over this," says Bundy. When New York State started talking about banning the practice of solitary confinement for teenagers, NewsHour suddenly wanted the story sooner. "That wasn't always supposed to be the first piece that was released on this," Bundy adds. Having the story told across platforms means you reach more people. Says Bundy, "There's some overlap between people who listen to public radio or watch NewsHour, or read Medium, but it's not total overlap. The benefit of having multiple platforms is that you are going to catch multiple, different types of audiences, hopefully."


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Wish I was going to Londa for Christmas
We love Christmas at Londa! We don't fuss but instead give guests a chance to unwind and be with family while we offer beautiful food at a good price. So if you want to take the stress out of the holiday, it's time to book your Christmas Eve and Christmas Day celebration meals at Londa Hotel.
The menus are incredible and promise something for the whole family. Vassos Michael, Londa's favourite head chef has put together a veritable virtuosity of tastes but as always he looks to his customers' desires for 'Health and Taste' as inspiration.
He says, "Over the last few years the trend is towards the healthy so I keep things simple. I have fresh ingredients like fish from the Med right next to us and wild mushrooms from Troodos; I don't want to change them too much and lose taste and vitamins in the process."
Why wait till the 25th? Start early and celebrate Christmas Eve
So get ready to lick your lips with a Christmas Eve Réveillon; five courses of the most elegantly prepared dishes, all so nutritious that you can beat the Christmas bulge before it even appears!
Based on the Mediterranean identity of the famous Caprice Restaurant and suited to the still warm temperatures of Cyprus (around 17 C at this time), the dishes served are not only creative – pheasant terrine and seabass being just two of the courses – but they also hold a surprise Christmas twist with an explosion of chestnuts in the Millefeuille for sweet. A great start to yuletide celebrations!
On Christmas Day you'll be completely stuffed!
For the big day, the crackers and party hats make the Christmas Roast Buffet lunch a real family affair. The turkey is unveiled alongside a buffet of 17 other dishes, and an additional dessert buffet. But the pièce de résistance is Vassos' stuffing. It's been presented at Londa every Christmas since Vassos started here 31 years ago, and we have persuaded him to share his Londa stuffing recipe with the world. "It's what I look forward to, it's good honest handmade stuffing and as I only get it once a year, I love it. And yes, I do make a bit extra for me to taste – who wouldn't?"
All wrapped up with a bow on top
How could we forget to tell you about the Christmas package? This could answer all your wishes for that luxury gift you've been looking for all along. It's for two people so you can treat your loved one to a superior side view room looking over the Mediterranean Sea, enjoy afternoon tea, the Christmas Eve Gala Dinner and breakfast the next morning, and you will still have time to get back home to the family for Christmas Day. The only question is – who do you want to thrill this Christmas?
Call us to book for Christmas Eve Tuesday 24 December 5-course Gala Dinner, or Christmas Day Wednesday 25 December Christmas Roast Buffet lunch or the A la carte evening dinner at Caprice Restaurant, or for the Christmas Eve one night package. +357 25 865 555 or email@example.com.
We look forward to seeing you.


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Advanced Search
At the 2007 National Educational Computing Conference (NECC), Inspiration Software kicked off a new online community for educators. The site, dubbed Inspired Learning Community, is designed for educators as "a place to discover and share ideas and resources for effectively using Inspiration Software's visual learning products to develop students' critical thinking skills across the curriculum," according to the company.
Inspiration Software is the developer of education software tools that include Inspiration, Kidspiration, and InspireData, all designed for K-12 institutions.
The new site is designed, according to the company, "to advance the use of visual learning at all age levels and in all subjects." It's available free to all educators and includes forums, blogs, and free lesson downloads. (It also allows educators to upload their own lessons for use by other members of the community.) See link below for more details.
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Proposals for articles and tips for news stories, as well as questions and comments about this publication, should be submitted to David Nagel, executive editor, at firstname.lastname@example.com.
About the Author
Executive Producer David Nagel heads up the editorial department for 1105 Media's education publications — which include two daily sites, a variety of newsletters and two monthly digital magazines covering technology in both K-12 and higher education.
A 21-year publishing veteran, Nagel has led or contributed to dozens of technology, art and business publications.
He can be reached at firstname.lastname@example.com. You can also connect with him on LinkedIn at linkedin.com/profile/view?id=10390192 or follow him on Twitter at @THEJournalDave (K-12) or @CampusTechDave (higher education). A selection of David Nagel's articles can be found on this site.
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George A. Poultsides, MD
Publication Details
An HNF4 alpha-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
2011; 147 (6): 1233-1247
Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629. Moreover, we show that, once this circuit is activated, it maintains suppression of HNF4α and sustains oncogenesis. Systemic administration of miR-124, which modulates inflammatory signaling, prevents and suppresses hepatocellular carcinogenesis by inducing tumor-specific apoptosis without toxic side effects. As we also show that this HNF4α circuit is perturbed in human hepatocellular carcinomas, our data raise the possibility that manipulation of this microRNA feedback-inflammatory loop has therapeutic potential for treating liver cancer.
View details for DOI 10.1016/j.cell.2011.10.043
View details for Web of Science ID 000298148100014
View details for PubMedID 22153071


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Taste Test: Best BBQ Sauce
21 nationally available barbecue sauces, both original and spicy, were evaluated with these 10 emerging as the finalists. Read on to see our tasters top picks:
Annie's Naturals Organic BBQ Sweet & Spicy Sauce ($3.69 for 12 oz.)
Annie's Naturals Organic Sweet and Spicy BBQ sauce was "sweet like ketchup" or "tomato paste." Some volunteers thought it lacked the heat they were looking for, while others felt it had a "good kick of spice at the end."


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Happy belated solstice, dear readers. We're officially in full-blown summer here in Columbus, with days that are sunny until after 9 pm and skies so moist that they're hazy.
Work breaks spent running around outside with the puppy now end with puppy and me collapsed in a panting heap, one of us sweating profusely and the other with tongue lolling sideways. (I'd like to say that we alternate in these roles, but the puppy doesn't sweat.) Humid heat is definitely not my favourite weather. Unfortunately, if temperatures rise into the future, I'll probably have to put up with humid heat more often and for longer periods at a stretch.
As I ponder ways to minimize my discomfort now and in a perpetually sweaty world – better insulation in the house, more shady trees, an industrial-sized fan? – I'm very aware that being sticky may be the least of my worries.
It seems there is growing consensus among climate scientists that we'll see increased variability in response to a changing climate. Increased variability is a technical term that just means less weather that is average and more weather that's extreme, on both ends of the spectrum.
One example of this shift could be that the total amount of rain during the year stays the same, but instead of falling gradually over several months, it'll come in short bursts of intense storms interspersed by long dry periods. That kind of increased rainfall variability was recently predicted for the Indian monsoon, described in this journal article.
Increased variability is generally bad news for us and the systems we depend on. Hurricanes, droughts, fires and floods – directly causing loss of life and injury, not to mention effects on drinking water supplies, crop yields, disease transmission, and so on – could all become more frequent and severe as the climate shifts.
But here's the rub: we don't really know for certain if these events will become more frequent, or how severe they might be if they do get more frequent.
That's the nature of working with the climate system; as the adage goes, climate is what you expect, weather is what you get. When a climate scientist tries to predict what the world might look like 20 years from now, all she can do is tell you what she thinks is likely to happen. She can't give you a precise forecast for a specific day. One source of uncertainty is the limitations in climate models, like parameterization schemes and things we've discussed in previous posts. But other sources of uncertainty are simply gaps in our knowledge due to imperfect observations and the chaotic nature of weather.
There will always be some degree of uncertainty associated with climate projections, no matter how good our science gets or how sophisticated our models become.
Which leads us to the subject of risk. Engineers know a lot about risk. So do farmers, surgeons and anyone else who has to work with a very low tolerance for failure. You want the person who designed the plane you're flying in to have figured out how the structure might fail and then have added a safety factor (or five) to reduce the risk of crashing. We encounter risk management in some form in many parts of our daily lives, whether we know it or not.
Risk is inherently tied to uncertainty. If we knew for certain what the outcome would be, there would be no risk involved in deciding on a course of action. (And Las Vegas might cease to exist.) So when we talk about the uncertainty of future climate changes and increased variability, what we're really talking about is climate risk.
Political rhetoric and standard business practice usually adopt the position that it is too expensive to take actions that mitigate against potential future climate change until we have more certainty about exactly how the climate will change. I interpret this argument as saying that the risk of future climate change currently seems too low to justify any investment that might safeguard against that change.
Now, I certainly don't want to tell people how much risk they should be willing to accept in their lives. I've willingly jumped out of an airplane at 15,000 feet, but I won't drive a motorcycle. Everyone accepts a different level of personal risk.
But, as we've talked about before, the climate system is not a personal issue. It's a regional and a global one. The potential impacts of increased climate variability will be felt by entire communities and countries.
So, how should we be thinking about climate risk? How do we evaluate the risk of future climate changes? What sort of steps, if any, should we be taking to protect ourselves against an unreasonable level of risk? Is there a way to quantify climate risk and incorporate that into our decision-making?
I really don't know the answers, but I think these are the questions that our politicians, engineers and other societal designers and decision-makers should be talking about. Recently, it seems that more scientists are also starting to think in risk language, to think about how climate uncertainty and the risk of climate variability might affect our societies.
For instance, a study published in 2011 examined the sensitivity of the US economy to weather variability. The idea behind that study was to get a quantitative feel for which parts of the US economy might be affected by future climate changes, i.e. to understand how vulnerable the US economy might be to climate risk.
The authors noted right up front that being able to predict the weather (and, implicitly, being able to make accurate climate projections) has important economic implications (see page 1 of this link):
"Weather directly and indirectly affects production and consumption decision making in every economic sector of the United States at all temporal and spatial scales. From very local short-term decisions about whether or not to pour concrete on a construction project to broader decisions of when to plant or harvest a field, to the costs of rerouting an airplane around severe weather, to predicting peak demand electricity generation in response to extreme heat, or to forecasting early season snow for a bumper ski season in Colorado, drought in the Midwest, or wind-fueled wildfires in California, weather can have positive or negative effects on economic activity."
Of course, one industry already thinking about the economic impacts of variable weather is insurance:
- A quick internet search in preparing this article showed insurance companies talking about how they evaluate the risk of future climate changes.
- An article in the New York Times last month quoted a couple of sources in reinsurance as saying that the insurance industry is less amenable to political persuasion than others and follows the consensus in scientific thought that climate change will bring an increase in extreme events.
- A public forum is being held in California on June 28 on the topic, "Insurance in an era of climate change", particularly as it pertains to wild fires, drought and vulnerable homeowners.
Clearly, the insurance industry has added climate change and climate variability to its risk analysis.
The 2011 study I mentioned just before suggests that insurance companies are wise to be thinking about climate risk: the results showed that "weather variability is significantly related to variability in economic activity in every state and sector", with sensitivity for each state and sector ranging from 2% to 14%.
The figure above shows the average economic sensitivity to weather variability for each state. Aggregating across all states and sectors, the study concluded that the range in US annual GDP affected by weather variability is approximately 3.36%, or $485 billion in 2008 dollars.
One way to interpret that result might be that we should be willing to spend up to half a trillion dollars to make our systems more resilient to climate risk, given that's the price tag of weather sensitivity.
Of course, the potential impacts of increased climate vulnerability will not be evenly spread across industrial sectors or geographic regions. One sector that has been the focus of more detailed study thus far is agriculture.
An article published last month investigated ways that policy-makers could make decisions about necessary measures to buffer agriculture against future climate impacts for different levels of climate change over different time frames.
The article noted that scientific data should be helping policy-makers to make better decisions by providing information of two kinds: projections of climatic impacts and assessments of adaptive capacity. These two kinds of assessments are illustrated in the figure at left. These assessments are, in essence, different kinds of risk assessments.
This is but one of an increasing number of articles I'm starting to see being published about how we might take steps to plan for future climate risk.
Uncertainty in general is not a reason for inaction; we take action based on a lack of certainty all the time in other areas of our lives and in society in general. I don't think the conversation should hinge on waiting until scientists have near perfect certainty about how the climate might unfold going forward, especially since we most likely will never have that kind of certainty.
Instead, I think the conversation about climate risk should proceed the same way we talk about other kinds of risk: quantify the type and level of risk as best we can with the knowledge at hand, decide how much we value the systems at risk of impact, and then invest in mitigation measures equal to the potential loss in value if we were to lose those systems.
I realize that climate risk is not just another type of risk in our lives, akin to the chance of a plane crashing. We're talking about the risk of change within an entire system that is much bigger than us, with high levels of uncertainty in some components and more certainty in others, and it's risk that will be felt across political boundaries. It's a larger degree of risk in all regards than anything we've had to deal with before.
But to quote the recent article about agricultural impacts (see page 1 of this link):
"The magnitude of plausible impacts, and costs of inaction or delayed action, mean that individuals and societies must undertake adaptation actions despite uncertainty."
We don't have to wait for 100% certainty about climate variability in order to make our societies more robust to environmental variability, more resilient to future disasters, and maybe even more profitable in the present. Many efficiency and waste reduction measures actually make business sense now, regardless of any environmental outcome. Other actions may provide new jobs, diversify the economy, make infrastructure less vulnerable and prepare people for increased hazards.
A website I came across recently – Climate CoLab – is a neat idea for crowd-sourcing ideas about climate change mitigation and reducing our vulnerability to climate risk. Ideas are split into different topics, such 'Urban adaptation: Climate resilient cities' and 'Enabling adaptation'. If you have a few minutes, it's good food for thought. How would you go about reducing our vulnerability to climate risk?
We've spent the past couple of months in this article series talking about some of the nitty gritty details of climate science and climate modelling. Although it involves a lot of physics, calculus, coding and other difficult subjects, in some ways the science is the easy part. Taking all that information and figuring out what we should do with it is much harder.
I am certain that I don't have the answers, and I'm pretty certain that there isn't one answer to be found. But I also don't think it's in our best interests to ignore the risk and hope it goes away. Humans are smart, resourceful and adaptable. We should act that way.
Yours in the pursuit of spaceships,
Missed what happened last time? Catch up on Episode 9 here.


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UpToDate is one of the most respected medical information resources in the world, used by more than 600,000 doctors and thousands of patients to find answers to medical questions.
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|AuthorFlor M Munoz, MD, MSc
|Section EditorPeter F Weller, MD, FACP
|Deputy EditorsElinor L Baron, MD, DTMHConstanza Villalba, PhD
Contents of this article
Giardia (also called Giardiasis or Giardia infection) is an infection of the gastrointestinal tract caused by a microscopic organism called Giardia lamblia. This parasite, which also goes by the names Giardia duodenalis or Giardia intestinalis, resides in the gut and can cause diarrhea and stomach discomfort (nausea, stomach ache). It is one of the most common gastrointestinal parasites, and it infects roughly 20,000 Americans each year.
Giardia can affect people of all ages, but it is especially common in children younger than five years old. It is also seen in internationally-adopted children of all ages and among people who travel in resource limited settings.
The Giardia organism is found in the feces of infected people and can spread because of poor sanitation or because drinking water or food becomes contaminated. It can also infect animals, such as dogs, cattle, and sheep, but it's not clear whether animals play a role in spreading the infection to humans.
How giardia is spread — Giardia infections can spread in three ways, all of which can be prevented. (See "Treatment and prevention of giardiasis".)
Waterborne transmission — Waterborne transmission is the most common route of infection. People who drink from contaminated streams, reservoirs, or wells can become infected. Contaminated water used to prepare drinks or wash raw food can also be a source of infection.
Waterborne transmission is especially likely among campers and hikers who drink from untreated water sources (streams, lakes), and among people traveling in regions where water sanitation standards may not be adequate to eliminate the organism.
Food-borne transmission — The organism that causes Giardia is killed by cooking, so properly cooked food rarely leads to infection. However, uncooked food or food that is contaminated after cooking can cause Giardia infections. (See "Patient information: Food poisoning (food-borne illness) (Beyond the Basics)".)
Person-to-person transmission — Person-to-person transmission can happen when traces of infected feces travel between two people. This can happen if someone does not thoroughly wash their hands after using the bathroom or after changing the diapers of an infected child. Person-to-person transmission is the cause of outbreaks in families and institutions, such as day care centers and nursing homes. Person-to-person transmission can also happen during anal sex or during sex play involving the anus.
Giardia infections do not always cause symptoms. Some people carry the organism without ever knowing it. What's more, some people develop symptoms and then get better without treatment, because they combat the infection on their own. When symptoms do arise, they can include:
●Diarrhea that comes on suddenly and may be initially watery
●Malaise (a vague feeling of discomfort)
●Foul-smelling and fatty stools
●Abdominal cramps, gas, and bloating
●Nausea or vomiting
●Weight loss
People generally develop these symptoms one to two weeks after being exposed to Giardia, and the symptoms often last at least two to four weeks. Some people develop a chronic form of Giardia that lasts even longer, although symptoms tend to be less severe.
Nutritional problems — Giardia can also interfere with the way the body absorbs nutrients, so it can cause vitamin deficiencies and other nutritional problems. In up to 40 percent of cases, Giardia impairs the body's ability to digest lactose, the form of sugar found in milk, cheese, and other dairy products. Guidance about lactose products is included below. (See 'Recurrence of symptoms' below.)
If your healthcare provider thinks you may have Giardia, he or she will ask you for a stool sample and then send it to the lab. There technicians will examine the stool under a microscope, looking for any parasites that might be present. The test, called the "ova and parasite exam," is important, because it can detect not just Giardia but also other parasites that might be causing or contributing to symptoms. (See "Epidemiology, clinical manifestations, and diagnosis of giardiasis".)
The test is not foolproof, because people infected with Giardia do not always carry the organism in the stool. As a result, you may need to provide more than one stool sample before the infection shows up on a test. Depending on your individual situation, your doctor might also recommend additional tests, such as endoscopy.
Treatment for Giardia involves taking an antibiotic for at least one day or several days. In most cases, that is enough to eliminate the infection and its symptoms. In stubborn cases that do not improve with the first round of antibiotics, doctors sometimes recommend changing the type, dose, or duration of treatment.
If you do not have symptoms of Giardia but testing shows that you are infected, you may not need antibiotic treatment. However, children in daycare and people who handle food should be treated for Giardia, even if they have no symptoms, to prevent the spread of infection.
Avoid swimming in pools, hot tubs, lakes, rivers, and the ocean until one week after you have finished treatment for Giardia. Swimming can contaminate the water and cause others to become ill. Avoid all types of anal sex until treatment has been completed.
If your symptoms resolve after you finish your antibiotic treatment, you do not need to be tested for Giardia again.
Special considerations for children — Antibiotics are the most important part of Giardia treatment both in children and adults, but children sometimes need additional care. Diarrhea can cause dehydration and a salt imbalance, both of which can be especially tough on children. For them, drinks containing electrolytes may be recommended to restore what is lost through diarrhea. Fluid and electrolyte replacement are discussed in detail in a separate topic. (See "Patient information: Acute diarrhea in children (Beyond the Basics)".)
The safety of breastfeeding while being treated for Giardia depends upon which antibiotic is used; some antibiotics are safe to take while breastfeeding while others are not. If you are breastfeeding, ask your healthcare provider if you can safely breastfeed while taking your antibiotics. (See "Patient information: Maternal health and nutrition during breastfeeding (Beyond the Basics)", section on 'Medication safety with breastfeeding'.)
Recurrence of symptoms — After being treated for Giardia and seeing symptoms improve, some people experience a relapse. This can happen because people consume dairy products too soon or because they are still infected with Giardia.
●Giardia can interfere with the body's ability to digest dairy products (see 'Nutritional problems' above). Even once the infection is gone, it can take several weeks before normal digestion returns. For this reason, adults may wish to avoid milk, cheese, yogurt, and any other foods that contain lactose for at least a month following treatment (table 1).
Milk products are an important part of a child's diet. Therefore, if your child continues to have loose stools or gassiness after beginning treatment for Giardia, have the child avoid milk and other dairy products for a few weeks. This is only to avoid symptoms, and does not help eliminate the Giardia infection itself.
●If you or your child develops symptoms again after being treated for Giardia, your healthcare provider will want to run another stool test to determine if Giardia is causing the problem. If Giardia shows up again, it could be that the first round of treatment did not get all the organisms, or it could be that you or your child were re-infected somehow. Work with your healthcare provider to root out the possible source of the infection and ask about how you can prevent future infections.
The key to preventing Giardia and other infections is good hygiene. Here are some good hygiene tips:
●Wash your hands with soap and water before eating and after using the bathroom, and teach children to do the same.
●Wash your hands with soap and water after changing diapers or after tending to anyone who has poor bowel control.
●Dispose of diapers properly and wash any clothes that could be contaminated with even small amounts of feces.
●Try not to swallow water when swimming.
●Pre-treat drinking water when traveling or hiking. This can be done by:
•Boiling drinking water for at least 10 minutes at a hard boil.
•Adding five drops of tincture of iodine to a quart of water and waiting 30 minutes. Iodine is much more effective in eliminating Giardia than chlorine-based (bleach) treatments.
•Using a high quality water filtration system. Information about water purification and a traveler's guide for buying water filters is available from the United States Centers for Disease Control and Prevention (www.cdc.gov/travel/).
●Use proper food preparation etiquette. Food preparation and safety tips are discussed in a separate article. (See "Patient information: Food poisoning (food-borne illness) (Beyond the Basics)".)
Your healthcare provider is the best source of information for questions and concerns related to your medical problem.
This article will be updated as needed on our web site (www.uptodate.com/patients). Related topics for patients, as well as selected articles written for healthcare professionals, are also available. Some of the most relevant are listed below.
Patient level information — UpToDate offers two types of patient education materials.
The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials.
Patient information: Giardia (The Basics)
Beyond the Basics — Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are best for patients who want in-depth information and are comfortable with some medical jargon.
Patient information: Food poisoning (food-borne illness) (Beyond the Basics)
Patient information: Acute diarrhea in children (Beyond the Basics)
Patient information: Maternal health and nutrition during breastfeeding (Beyond the Basics)
Professional level information — Professional level articles are designed to keep doctors and other health professionals up-to-date on the latest medical findings. These articles are thorough, long, and complex, and they contain multiple references to the research on which they are based. Professional level articles are best for people who are comfortable with a lot of medical terminology and who want to read the same materials their doctors are reading.
Antiprotozoal therapies
Epidemiology, clinical manifestations, and diagnosis of giardiasis
Treatment and prevention of giardiasis
The following organizations also provide reliable health information.
●National Library of Medicine
●National Institute of Digestive and Diabetes and Kidney Diseases
●Center for Disease Control and Prevention
●American College of Gastroenterology
All topics are updated as new information becomes available. Our peer review process typically takes one to six weeks depending on the issue.
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Hello. I am completely frustrated trying to temper milk chocolate. I have a tempering machine. It is called the "little dipper" from Hilliards.As soon as I am finished refining the milk chocolate…Continue
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I am having a difficult time looking for equipment to start making chocolate. I've never made any before and don't want to spend thousands to see if I am any good. I also don't want to be too cheap…Continue
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The TV at my grandmother's house. It was grey with wooden panels – or was that the cabinet it was in? – and next to it was a telephone on a table, one of those where you had to pull … (script)
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Health Tip: Shopping for Skin Care Products
(HealthDay News) -- When choosing cosmetics, cleansers and moisturizers, it's important to know your skin type.
The Cleveland Clinic mentions these factors to consider when shopping for skin care products:
Skin type: Is it sensitive, oily, dry, normal or a combination of these?
Complexion: Is it fair and burns easily, a medium skin tone that typically tans and rarely burns, or a dark skin tone that never burns?
Skin problems: Do you want to avoid premature aging, a condition such as acne or rosacea, or problems such as wrinkles or sun damage?
Personal lifestyle and habits: These include: history of smoking, sun exposure, and vitamin and nutrient consumption.
- Having Eczema Won't Make You Shorter
December 10, 2014
- Health Tip: Easing Hand Eczema
November 28, 2014
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Sharp HealthCare is San Diego's health care leader with seven hospitals, two medical groups and a health plan. Learn more about our San Diego hospitals, choose a Sharp-affiliated San Diego doctor or browse our comprehensive medical services.
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Stay Informed! The Open Government to the MAX! system allows the citizens and professionals of Amherst to subscribe to receive meeting notifications via through our Notify Me system, view meetings through iCal, subscribe to RSS feeds, stay informed automatically though Facebook and much more. Check it out!
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text: 4 Visually impressive despite familiar story elementsKevin1075 | 13/08/2013 | See all Kevin1075's reviews (754)Top 100 Reviewer Top 100 DVD Reviewer Top 100 Music Reviewer The four stars is really more of a very high 3.5 as I'm being maybe a little more generous thanks to being a Sci-fi fan, but even at that, 'Oblivion' is one of the more beautifully realised films of the year, even if the final story remains one that you'll realise you've seen elements of before.Several decades in the future the Earth has been left desolated and ravaged after alien invasion. With the last of it's natural resources about to be harvested by humanity Jack (Tom Cruise) remains one of the last people on Earth overseeing the machinery before he evacuates to the space station which the rest of the human race live on. Until, a spaceship crashes in his patrol area revealing inside a women whom Jack has had recurring dreams about. A woman who also seems to know who Jack is.In finding out the answer to this mystery, Jack's entire perception of his world will be changed.Director Joe Kosinski (Tron: Legacy) proves himself to be a developing master of visual science fiction, and 'Oblivion' is truly stunning from an effects and production design perspective. But the thinnish characters and ultimately derivative plot which the visuals mask do undermine some of that effort. It's also got a fantastic music score from M83 that pulses and matches the visuals perfectly at times.I really enjoyed it for what it was, but 'Oblivion' probably thinks it's a slightly better sci-fi film than it actually is.


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Spicy Beer Boiled Shrimp
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Spicy Beer Boiled Shrimp
|Thu, 03-21-2013 - 6:27am
Spicy Beer Boiled Shrimp
1 (12 ounce) bottle beer (not dark or amber)
1 tablespoon hot red pepper flakes
1 tablespoon whole black peppercorn
2 bay leaves
2 lbs raw shrimp, shells on but legs removed
1/2 cup butter
2 tablespoons lemon juice
1/4 teaspoon cayenne pepper
bottled seafood cocktail sauce lemon wedge
Combine the beer, pepper flakes, peppercorns and bay leaves in a large heavy saucepan. Bring to a boil, then boil for 2 minutes. Add the shrimp. Cover and cook until the shrimp are cooked through, about 5 minutes. Drain.
Melt the butter. Stir in the lemon juice and cayenne pepper.
Serve the shrimp with the butter mixture, cocktail sauce and lemon wedges. Peel and eat.


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Jen Ames-Brown
-Serving the Portland Metro Area-
Phone: 858-437-2298
Email: email@example.com
As a labor and delivery doula, I am honored to be able to serve women and families during such a special moment. I believe that no matter what your medical chart says about your child's birth, with a birth team that empowers you, your experience can be positive.
I've been studying and learning about birth for more than five years. My classroom training in Birthingway College of Midwifery's Labor Doula program provided me with the opportunity develop my skills and knowledge on a deeper level. I am well-versed in unmedicated birth, various coping mechanisms, weighing options for interventions and working with providers.
As a labor and delivery doula, I offer the following:
- 2 prenatal visits during which we get to know each other. We discuss your hopes and wishes for your upcoming birth and what sorts of strategies or tools we might use to achieve it.
- on-call support for 2 weeks prior to your due date and 2 weeks after. We'll stay in touch via phone or text or email.
- When you're in labor, I'm available to join you at your home while you labor. When you decide to go to the hospital, I'll be there to support you until the baby is born. I'm able to help with those first breastfeeds. I usually leave about an hour after the birth.
- 1 or 2 postnatal visits during which we'll talk about your transition with the new baby. I can help with breastfeeding. We can also talk about your birth and help you complete that story.
In addition to providing support to families during birth, I enjoy offering photography during your labor and delivery.
I especially enjoy working with LGBTQ couples, VBAC mamas, military families and single parents.
The emotions and perceptions of a child's birth play a very important role in the formation of you as parent and the family as a whole. I look forward to talking with you about your birth and how we can work together!!


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Licensed pharmacies in Mexico are only allowed to sell medications, either brands or generics, from an approved pharmaceutical which has passed testing and has subsequently been authorized by the Mexican Government.
If you look on the left at About US you will see our licenses, permits and our Regulatory Body. Our goal is to offer you the best possible prices with excellent service. When you place an order to ensure our messages reach your mailbox (and not the spam folder), please add email@example.com to your addresses book.
All of our pharmacies are open 24 hours a day, 365 days per year. We speak Spanish and English.
Generic Name: melatonin (meh lah TOE nin) Sublingual tablets.
Melatonin has been used to ease insomnia, combat jet lag, protect cells from free-radical damage, boost the immune system, prevent cancer, and extend life. The use of melatonin in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal/health supplements, consultation with a primary health care professional is advisable.
Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous. Melatonin is naturally produced in the body in response to the perception of light. Melatonin has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of melatonin may not be known. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Melatonin may also have uses other than those listed in this product guide.