text:
Crown Castle Announces Final Results Of Cash Tender Offer For 9.00% Senior Notes Due 2015
HOUSTON, Jan. 10, 2013 (GLOBE NEWSWIRE) -- Crown Castle International Corp. ("Crown Castle") (NYSE:CCI) announced today the final results of its previously announced cash tender offer ("Tender Offer") for any and all of its outstanding 9.00% Senior Notes due 2015 (CUSIP Number 228227 AZ 7) ("9% Notes"). The Tender Offer expired at 11:59 p.m. (EST) on January 9, 2013 ("Expiration Date"). The terms and conditions of the Tender Offer are described in the Offer to Purchase and related Letter of Transmittal dated December 11, 2012, distributed to holders of the 9% Notes.
In accordance with the terms of the Tender Offer, Crown Castle previously accepted for purchase approximately $515,458,000 aggregate principal amount of 9% Notes, which were validly tendered on or prior to 11:59 p.m. (EST) on December 24, 2012 ("Early Tender Date"). An additional $839,000 aggregate principal amount of the 9% Notes have been validly tendered after the Early Tender Date but on or prior to the Expiration Date and accepted for purchase by Crown Castle in connection with the final settlement of the Tender Offer. Holders who validly tendered their 9% Notes after the Early Tender Date but on or prior to the Expiration Date and whose 9% Notes were accepted for purchase will receive $1,032.30 per $1,000 principal amount of 9% Notes (plus accrued and unpaid interest), subject to the terms and conditions set forth in the Offer to Purchase and related Letter of Transmittal.
Acceptance of the 9% Notes for purchase was subject to the satisfaction or waiver of certain conditions as set forth in the Offer to Purchase and the related Letter of Transmittal.On December 24, 2012, Crown Castle delivered to the holders of the 9% Notes a notice of redemption. Accordingly, all of the remaining then outstanding 9% Notes (approximately $313,331,000 aggregate principal amount) will be redeemed on January 23, 2013.
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text:
Welcome to the Vermont Human Rights Commission
The mission of the Vermont Human Rights Commission is to promote full civil and human rights in Vermont. The Commission protects people from unlawful discrimination in housing, state government employment, and public accommodations.* We pursue our mission by:
- Enforcing laws
- Mediating disputes
- Educating the public
- Providing information and referrals
- Advancing effective public policies on human rights
* A place of public accommodation is any establishment, such as a school, restaurant, office, or store that offers facilities, goods or services to the general public.
The Vermont Human Rights Commission envisions a society in which:
- People treat each other with dignity and respect
- Communities promote equality, fairness, understanding and acceptance of all
- Citizens act effectively to end discrimination.
We envision the Commission as a dynamic leader in the pursuit of social justice. To this end, the Commission will:
- Collaborate with public, private, and non-profit organizations
- Conduct efficient and effective enforcement
- Provide an authoritative voice with respect to civil rights in Vermont.
Please see the links below and in the lefthand column for more information:
File a Complaint
Disability Issues
Click here for information about how to file a complaint.
Click here for information, materials, and resources about disability issues in employment, housing, and public accommodations.
School Harassment
Housing Issues
Click here for information, materials, and resources about school harassment.
Click here for information, materials, and resources about fair housing.


text:
Database Manageability
Database Manageability
Oracle Database 12c is the next generation self-managing database that helps businesses lower their IT operational costs while providing maximum performance and availability. This self-managing database automatically monitors, diagnoses and tunes itself. The Oracle Database 12c manageability features allow DBAs to become more productive, and helps their organizations reduce management costs and scale to manage the Enterprise Computing Grid.
Upgrading to Oracle Database 12c is faster and easier than ever before. The database upgrade process has been streamlined over the past several releases and the development effort required to upgrade, test, and verify an application has been greatly reduced. For more information on the right planning, preparation, and upgrade steps, please go to the Oracle Database Upgrade page on OTN.
Some of the features referenced below are part of separately licensed Diagnostic Pack, Tuning Pack and Real Application Testing Option. Please refer to the Oracle Database Licensing Documentation for more details.
News and Views
|Data Masking Total Cost of Ownership Study: Oracle Data Masking Delivers 242% ROI
|Database Manageability and Productivity Cost Comparison Study : Oracle Database 11g Release 2 vs. IBM DB2 Enterprise 9.7
|Managing the Rapid Rise in Database growth : 2011 IOUG Survey on Database Manageability
|Active Reports: Real-Time SQL Monitoring
|Technical comparison of Oracle Database 11 g and Microsoft SQL Server 2008: Focus on Manageability


text:
Groups > Overview | New | Recently Active | Random
Group Administrator
Calgary, AB
Join Group
Invite Others to Join
Group Overview
This group was started on October 7th, 2013 and currently has:
RSS Feeds
About This GroupHow many holidays are there? Each country has different holidays and themes as well as similar holidays and themes.
This group is to highlight the international/national holidays of our great big globe.
All media is accepted except adult content.
Please submit three images to group. Make it your very best of the best!
No abuse of members in group
Feel free to put a description on your work to highlight just how good you are
I will put up contests each month but they will be for the more recognized holidays. I will put up a list of the worlds celebrations every month in the discussion area so you can get an idea of what goes on and when submitting regular work for the gallery you can add your description to let us know what holiday or celebration you are adding.
Have fun!
Just want to say in advance to all who are featured I have the honour of doing this for you not because of me but because of your fine and great talent so in advance I thank each and everyone for joining this group and submitting your work and rest assured I do look at each image and although I would love to feature all of them I try to pick what I feel is the very best out of them to display on the home page.
I also want to thank all members who submit any work that is not put on feature page as they are all great and it is very hard for me to decide sometimes which ones should be featured. You make up this group I am just the person who gets to enjoy and be amazed at all your wonderful talent.
Best regards!
Featured Images
Michelle Frizzell-Thompson
Lucinda Walter
Christine Wiegand
Charline Xia
Fineartist Ellen
Michelle Frizzell-Thompson
Anne Gilbert
The Creative Minds Art and Photography
The Creative Minds Art and Photography
Inspired Nature Photography By Shelley Myke
Janette Boyd
Miriam Danar
Dan Sproul
Lucinda Walter
Miriam Danar
Chad and Stacey Hall
Christi Kraft
Fineartist Ellen
Darrell Young
Thomas Woolworth
Michelle Frizzell-Thompson
Anne Gilbert
Thomas Woolworth
Alexander Senin
John Malone
Jennifer Doll
LeeAnn McLaneGoetz McLaneGoetzStudioLLCcom
LeeAnn McLaneGoetz McLaneGoetzStudioLLCcom
Alexander Senin
LeeAnn McLaneGoetz McLaneGoetzStudioLLCcom
Inge Riis McDonald
Michelle Frizzell-Thompson
Anne Gilbert
Thomas Woolworth
JoNeL Art
Jean Hall
Dan Sproul
Jeffrey Koss
Janette Boyd
John Malone
Thomas Woolworth
Jim Fitzpatrick
Jeffrey Koss
Please Wait...


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18-21.04.2014. in double room with half board and bunny programs ( funny Easter eggs hunting in the garden, puppet-show)
|Single room
|63,80 €/prs/nights
|Comfort Plus double room
|43,80 €/prs/nights
|Premium Style double room
|49,80 €/prs/nights
|Premium View double room
|50,80 €/prs/nights
31.03.2012. Easter-Sunday with rich child programs
|Local tax
|above the age of 18
|Single room
|+20€ /pers. /night
|Comfort Plus Double room
|instead of +6€/pers./night
only just gratis
|In 2012 renewed room for 2 persons
(1 extra bed may be added),
partly with air condition.
|Premium Style Double room
|+12€ /pers. /night
|In 2012 renewed rooms for 2 persons,
with unique and attractive exterior (Pink or Orange),
partly with air condition.
|Premium View Double room
|+14€ /pers. /night
|Renewed rooms for 2 persons, with unique and
attractive exterior (Pink or Opal), balcony with
a panoramic view, partly with air condition.
|2013-03-08 14:28:29
Takes the opportunity try out our Xbox games!
Information at reception desk.
|Family and Child-friendly Services
|2013-12-09 09:55:08
Szállodánk gyermekes családok részére a következő szolgáltatásokat kínálja:
|Read more...


text:
Makita 18V Compact Drill/Driver Hot
Product Info
• Variable 2-speed (0-400 & 0-1,500 RPM) covers a wide range of drilling and driving applications
• Compact and ergonomic design at only 7.5" long and weighs only 3.3 lbs. for reduced operator fatigue
• Built-in LED light with afterglow illuminates the work area
• Rubberized soft grip provides increased comfort on the job
• Makita 18V Compact Lithium-Ion batteries charge in only 15 minutes
• Accepts Makita 18V LXT 3.0-amp-hour lithium-ion battery for even longer run time
• 3-year warranty on tool and 1-year warranty on batteries and charger
Editor review
Last updated: January 04, 2012
Top 500 Reviewer - View all my reviews
Best torque, long run time, light weight
This test-lightest drill (of 8 compacts) works as hard as a heavyweight. It topped our lag-screw driving test, had the second-highest run time, and the fastest battery recharge time. The clutch and speed selections click positively into place. (And the charger entertains you with strains of classical music when the battery
tops off.)
User reviewsView all user reviews
Average user rating from: 7 user(s)
|Overall rating
|4.7 (7)
|5.0 (7)
|Ease of Use
|5.0 (7)
|4.7 (7)
Top 50 Reviewer - View all my reviews
Love this Drill/Driver
I got this in Jan. of 2009. It is the best, bar none, cordless drill I have ever had. It runs for a long time between charges, is super strong, and super light. It's the only cordless drill I will ever buy new batteries for, instead of a new drill. I have purchased new batteries for this, and I feel they are priced very high. My first battery failure was after 2 years. Lastly as stated in other reviews it does charge extremely fast.
Last updated: October 21, 2012
#1 Reviewer - View all my reviews
Makita does it again
The usual flawless Makita performance. I've used this drill now for at least two or three years and have had no issues with it at at all. I've owned Panasonic, Ryobi and Bosch drills in the past but this is the best so far. Part of that I'm sure is due to the fact that most of the cordless drills on the market now are Lithium Ion batteries. So much more reliable than the old NiCads. I like the light on this one. It helps a whole lot when your working inside a dark cabinet. It comes on when you activate the trigger and stays on for a few seconds afterward.You can just touch the trigger momentarily and the light comes on. This helps you to see where your about to drill or drive. The light om my new Porter Cable Lit Ion only stays on while the trigger is activated and turns off when its not. Makita did the light right too! Fast recharge , light weight, and long battery run times puts this drill at the top.The belt clip is also a real plus !
Top 100 Reviewer - View all my reviews
3rd time not a charm
I'm on my third drill like this. The first two have lasted an exceptional number of years. The third one, which was recently bought, has a severe problem with the chuck. It seems loose and wobbly. Very annoying on certain applications.
Top 50 Reviewer - View all my reviews
Best Drill I Have Ever Used
Great Drill. The main reason I bought this drill was how light it is, yet so very powerfull. I can use it overhead and not run out of steam myself. It will do just about and thing a hand drill should do, and do it better than any other drill that I have ever used. The recharge time is faster than I can use up the second battery so I am never without power and can run nonstop.
Last updated: June 02, 2012
Top 10 Reviewer - View all my reviews
I Love this Drill!
I've had several drills over the years, and this one is a far superior unit. I bought it as a set with the impact driver. It's lightweight so it doesn't aggravate my chronic Tennis Elbow. It has a secure, comfortable grip, and is well balanced. It has plenty of boring power for my needs (woodshop, home carpentry, and some home improvement projects). The Li ion battery life is longer than several other brands I've used. I also love the fact that the charger plays you a little classical tune when a battery pack is fully charged. A very classy touch! Someone had a sense of humor when designing it. This is the one I reach for first, and it is a real pleasure to use.


text:
Stateside, the headlines are filled with news from the political conventions, but Cameron Sinclair turned down both to go to Venice for the 13th International Architecture Exhibition. Many of the people who arrived in Venice for the biennale preview are beginning to leave, but others are still reveling in the limelight of winning awards, and public visitors are still taking in the 55 national pavilions and myriad other exhibitions on display.
Click here for ARCHITECT's complete coverage of the 2012 Venice Biennale.
Sponsored EDUCATION
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ARCHITECT Staff
Please read our Content Guidelines before posting.
Check out these stories, which take a close look at innovative projects that are using wood in creative ways. Proudly sponsored by reThink Wood.
ARCHITECT offers architecture news, market intelligence, business and technology
solutions, continuing education, building products, and other resources for practicing
Copyright ©
2014 Hanley Wood Media, Inc. All rights reserved.


text:
You must log in to access this feature. Sign in with Twellow or Facebook to get started.
By signing in to Twellow, you indicate your agreement to our terms of service.
Simply connect with Facebook and kiss those password blues away,
or go here to reset your password.
Official twitter feed for Jane Fonda - Actress, Author, Activist, Fitness Advocate. Like me on Facebook! http://t.co/si3qUNa0. Or visit http://t.co/izyKmyiC


text:
Multiplex SNP Assays
The SNPWave technology can detect several to 30 SNP loci simultaneously. A multiplexed SNP detection assay reduces the costs per SNP datapoint considerably compared to monoplex SNP detection assays. SNPWave is therefore most suitable fro high-throughput diagnostic purposes.
How it works
Figure 1: Basic principle of SNPWave Multiplex allele-discrimination based on ligation using probes with unique stuffer (green), differing 2 basepairs (bp) between alleles of a SNP locus and 3 bp between SNP loci.
Figure 2: Example of a SNPWave assay. Reconstruction of a gel image of SNPWave reaction products from 16 individuals. Each column shows a different fingerprint that represents a specific haplogroup. (Column x represent an example fingerprint as a demonstration of a forensic case matching profile #13).
- Genotyping;
- variety determination;
- allelic variation detection;
- diagnostic assays;
- micro-organism detection;
- Mixed population detection.
- Multiplex allele discrimination;
- full design based on single pair of primers per allele;
- Detection on several platforms.
- Design based on a set of 10-30 SNP's;
- delivery of fully tested SNPWave assay within 3 months;
- 10,000 reactions are delivered at the first order.
- Multi marker assay in vegetables
- Multi marker assays in field crops
- Y-Chromosome
- Coeleac Disease diagnostic assay
More info
Herco van Liere
Vice-President Business Development


text:
General G-MAX AS-03 Tires
Our inventory changes frequently so please check back soon or search. Some tires may be discontinued and not available.
General G-MAX AS-03 P245/45ZR18 Tire Specifications
All-season ultra-high performance tire developed to deliver precise response in dry and wet conditions with excellent light snow grip.
The TireTeam Difference
- We have over 200,000 new tires in stock. We do not sell 'seconds' or used tires.
- Orders received before 3pm EST M-F ship same day.
- Save on thousands of name brand and inexpensive tires when purchasing from a factory direct distributor.
- When interlocked, the tread blocks work together to improve handling and reduce heat for increased treadlife
- Channel and direct water out of the tread for excellent resistance to hydroplaning
- Replacement Tire Monitor (RTM®) and Vicual Alignment Indicators (VAI®) alert drivers of misalighment and treadwear conditions
- Expose more biting edges to enhance traction in wet and snowy conditions
- 3-D Sipes
- V-Shaped pattern with aqua-cleave groove elements
- Monitor technology
- Strake grooves
Please Note: Specifications of the General G-MAX AS-03 tires shown above are listed to be as accurate as possible based on the information provided to us by General tires.
Other Sizes For G-MAX AS-03
Related Tires by Size
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Saul Ludwig reports to Modern Tire Dealer that many manufacturers are scrambling to increase productio …Read More . . .
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For the second time in 2010, Continental tires Tire the Americas is raising prices on its passenger …Read More . . .
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Continental Tire the Americas introduced a new tire, the Continental ProContact with Eco Plus Techn …Read More . . .


text:
72-7385 - 3MHz Function Generator/Counter
3MHz Function Generator
The 3MHZ GFG-8216A utilizes proven, traditional function generation technology with a frequency counter, TTL/CMOS output and VCF (Voltage Control Frequency), the GFG8250A is a reliable, feature rich instrument. Operating at up to 3MHz the...
Mfr Name: GW Instek
Mfr Number: GFG-8216A
See all items in Function Generators
72-7380 - 3MHz Function Generator
3MHz Function Generator
Entry level function generator offers a complete solution for generating signals up to 3MHz. The GFG-8215A features standard functions such as TTL/CMOS/Ramp outputs and external voltage controlled frequency (VCF). The GFG-8215A operates at...
Mfr Number: GFG-8215A
72-7360 - 3MHz Sweep Function Generator with AM/FM Modulator
3MHz Function Generator with AM/FM Modulation
The 3MHZ GFG-8219A is one of the most feature rich function generators in the GFG-8200 range. It is embedded with standard functions such as TTL/CMOS/Ramp output, external Voltage Controlled Frequency (VCF), as well ...
Mfr Number: GFG-8219A
115-TL074CD - 3Mhz 16V/Us SOIC-14 Op-Amp
STMicroelectronics SemiconductorsOriginally created as SGS Thomson Microelectronics in 1987, from a merger of SGS Microelettronica and Thomas Semiconductors, and renamed to STMicroelectronics in 1998. ST is among the world's largest semiconductor manufacturing com...
Mfr Name: STMicroelectronics
Mfr Number: TL074CD
See all items in Audio Power Amplifiers
115-TL074IN - 3Mhz 16V/Us DIP-14 Op-Amp
Mfr Number: TL074IN
107-FEP16DTA - RF Power Trans PNP -80v 3mhz To220
Fairchild SemiconductorsFairchild Semiconductor's portfolio of power semiconductor, discrete semiconductor, analog signal and switch, logic, and optoelectronic products serves diversified markets and applications, including mobile, computing, communications, consu...
Mfr Name: Fairchild Semiconductor
Mfr Number: FEP16DTA
See all items in General Purpose
123-TIP31BG - Power Trans NPN 80V 3mhz To-220
ON Semiconductor is a premier supplier of high performance silicon solutions for energy efficient electronics. The company's broad portfolio of power and signal management, logic, discrete and custom devices helps customers efficiently solve their design challenge...
Mfr Name: On-Semiconductor
Mfr Number: TIP31BG
123-TIP32BG - Power Trans PNP -80v 3mhz To220
Mfr Number: TIP32BG
123-TIP32CG - Power Trans PNP -100v 3mhz To-220
Mfr Number: TIP32CG
123-TIP42CG - RF Transistor PNP -100v 3mhz To-220
Mfr Number: TIP42CG
123-TIP36CG - RF Transistor PNP -100v 3mhz To-218
Mfr Number: TIP36CG
24-14390 - 1000FT RG6Q Plenum 18AWG BC 60/40 AL BRAID;SPOOL;White
1000ft RG-6 Quad-Shield 3MHz Plenum Coax Cable
Plenum rated (CMP) RG6 quad shield coax cable for digital HDTV, CATV,
MATV and digital satellite RF distribution cable drops
in ceilings and tray runs where building codes require low smoke and flame.
Mfr Name: Structured Cable
Mfr Number: RG6/UQ-P-SPL
See all items in RG6
24-14385 - 1000Ft RRG6 Direct Burial 18Awg BC 60/40 Al Braid;Spool; Black
1000ft RG-6 Quad-Shield 3MHz Direct Burial Coax Cable
Direct burial rated RG6 quad shield coax cable for digital HDTV, CATV,
MATV and digital satellite RF distribution cable drops
in high moisture areas.
Mfr Number: RG6/UQ-DB
Great as always. No trouble to place order and no problems with it. It was delivered on time just as they said it would. I have ordered here several times and will continue to do so!


text:
give me what i want or there's gonna be a riot
More surveys for you kiddos. last cigarette || at the ashley's firemans bazaar.. a couple weeks ago.last kiss || hmpf. i'm pathetic. never.last good cry || couple days ago.last library book || the one emily recommended. what was it called? something about a queen.last movie seen || at a movie theater? hmm. can't remember. last book read || harry potter and the order of the phoenix. hehe.last cuss word uttered || shit?last beverage drank || iced tea.last food consumed || shrimp salad. last crush || neil.last phone call || mollie and emily. last tv show watched || infomercials.last shoes worn || flip flopslast time showered || this afternoon, around 1:00.last cd played || waiting for sunset - at sixes and sevens hehe.last item bought || does ice cream count? no? okay then that ^last thing downloaded || yellowcard - rough draft, 'cause everyone is saying it's good.last annoyance || having to sit outside with my mom, mike, their friends, and their son.last disappointment || myself hah.last soda drank || diet pepsi.last thing written || my name on a reciept.last key used || house key.last word spoken || "yeah."last sleep || from 3:45ish am to 12:20 pm. last weird encounter || hmm. the other day. weird men harrassing us. last time you fell in love || i've never been in love.last time resentful || it seems like i always resent something.last lipstick used || i don't use lipstick, i use lipgloss. ;)last chair sat in || this one, my computer chair. last underwear worn || pink ones.last bra worn || a white one.last shirt worn || pinkish t shirt.last time dancing || haha, me and emily dancing to gc and sean paul the other night.last poster looked at || my dc one.last show attended || local- courage is for cowards, come monday, nor the arrow, waiting for sunset, and of all days. last website visited || sf forumlast song heard || yellowcard - rough draft last injury || geez, i don't know. i guess that's a good thing.last word you said ||||| "yeah."last song you sang ||||| catch 22 - "dear sergio"#E6E6FAlast thing you laughed at ||||| something my mom and mike were saying.last time you said i love you ||||| to my mom.. when i don't know.what color socks are you wearing ||||| none.FAstory behind your journal username ||||| bad_star = part of a finch song. favorite place to be ||||| home? a sf show? with my friends.. yeah, anywhere with them.least favorite place to be ||||| with family.strong in mind or strong in body ||||| strong in mind.time you wake up in the morning ||||| i wake up in the afternoon.. anywhere from 12 to 3.favorite color ||||| black, white, or blue.Ado you like these colors ||||| yes, i do. do you believe in an afterlife ||||| i'm not sure.how tall are you ||||| 5'7"favorite words ||||| kid toucher, closet freak, interesting (just 'cause i say it a lot) there's others, but i can't think of any at the moment. favorite season ||||| summer.one person from your past you wish you could talk to ||||| hmm, i'm not sure.E6E6FAfavorite day ||||| friday.random lyric ||||| i sleep so i don't have to feel.kindergarten teacher's name ||||| ms. quick. (is that how you spelled her name?)first grade teacher's name ||||| mrs. nardiello.second grade teacher's name ||||| mrs. ostroski.third grade teacher's name |||| why can't i think of her name? i have to get my 'school memories' book out for this one. oh yeah, mrs. keating.fouth grade teacher's name ||||| mrs. middleton. (i'm just going to name my homeroom teachers)fifth grade teacher's name ||||| ms. jordan. sixth grade teacher's name ||||| mrs. rossFAseventh grade teacher's name ||||| mrs. middletoneighth grade teacher's name ||||| mrs. martinhigh school teacher's names ||||| alright.. mr. barno [h.r. (ricardo)], sr. janice, mr. milz (bill), mrs. fisher, fr. asante, mr. krehely, mr. barno (juan), mr. faust, ms. pawlenok, mrs. flaherty, and ms. manganiello. high school classes ||||| so far -- theology 1, christian service hah, spanish 1, latin 1, honors algebra 1/algebra 2, honors physical science, honors english 1, honors western civilization, health/pe, music appreciation, intro to art, and freshman writing seminar.And while I'm making a public post, I might as well say this. I want some male blurty friends. I have all girls. Not that that's bad or anything, I just want to mix it up a bit. So if any guys come across my journal, you best add me. -miller
(Reply to this) (Parent) (Thread)
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text:
Spectacularly sandwiched between the Strait of Georgia and the soaring Coast Mountains, Vancouver is Canada's most westerly metropolis. The city plays dual roles—it's both a luxury resort town and a bustling industrial seaport—and it mixes a dynamic high-rise skyline with expanses of natural beauty. Vancouverites are a genial bunch, and it's no wonder—when they're not relaxing at coffeehouses, they can be found rollerblading along the ocean around Stanley Park or doing yoga on the beach. The greater Vancouver area is home to a diverse mix of cultures—traditional Native/First Nations and European heritages mix here with Chinese, Japanese, and Indian communities—and the international spirit was only reinforced in 2010, when the city hosted the Winter Olympic Games.
Don't Miss
Taking a sunset stroll along the seawall from English Bay Beach to Stanley Park's Second Beach Pool.
Exploring the dynamic public market and many artisans' studio-shops on Granville Island.
Sushi—it's everywhere, and nobody can agree on a favorite place. Just pick a spot near your hotel and go in and try some.


text:
Willmar, MN 56201ph: email@example.com
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I took these on Thanksgiving Day. Starlings on the power lines across the street from my son's house made great silhouettes. Reminded me of Rita Coolidge's song from her "The Lady's Not for Sale" album.
Bird on a Wire
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Association For Molecular Pathology et al v. United States Patent and Trademark Office et al
Filing 62
MEMORANDUM OF LAW in Support re: 61 MOTION for Summary Judgment.. Document filed by American Society For Clinical Pathology, College of American Pathologists, Association For Molecular Pathology, Haig Kazazian, Arupa Ganguly, Wendy Chung, Harry Ostrer, David Ledbetter, Stephen Warren, Ellen Matloff, Elsa Reich, Breast Cancer Action, Boston Women's Health Book Collective, American College of Medical Genetics, Lisbeth Ceriani, Runi Limary, Genae Girard, Patrice Fortune, Vicky Thomason, Kathleen Raker. (Hansen, Christopher)
Association For Molecular Pathology et al v. United States Patent and Trademark Office et al Doc. 62 UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF NEW YORK --------------------------------------------------------------------------x ASSOCIATION FOR MOLECULAR PATHOLOGY; AMERICAN COLLEGE OF MEDICAL GENETICS; AMERICAN SOCIETY FOR CLINICAL PATHOLOGY; COLLEGE OF AMERICAN PATHOLOGISTS; HAIG KAZAZIAN, MD; ARUPA GANGULY, PhD; WENDY CHUNG, MD, PhD; HARRY OSTRER, MD; DAVID LEDBETTER, PhD; STEPHEN WARREN, PhD; ELLEN MATLOFF, M.S.; ELSA REICH, M.S.; BREAST CANCER ACTION; BOSTON WOMEN'S HEALTH BOOK COLLECTIVE; LISBETH CERIANI; RUNI LIMARY; GENAE GIRARD; PATRICE FORTUNE; VICKY THOMASON; KATHLEEN RAKER, Plaintiffs, 09 Civ. 4515 (RWS) ECF Case v. UNITED STATES PATENT AND TRADEMARK OFFICE; MYRIAD GENETICS; LORRIS BETZ, ROGER BOYER, JACK BRITTAIN, ARNOLD B. COMBE, RAYMOND GESTELAND, JAMES U. JENSEN, JOHN KENDALL MORRIS, THOMAS PARKS, DAVID W. PERSHING, and MICHAEL K. YOUNG, in their official capacity as Directors of the University of Utah Research Foundation, Defendants. --------------------------------------------------------------------------x PLAINTIFFS' MEMORANDUM OF LAW IN SUPPORT OF MOTION FOR SUMMARY JUDGMENT Daniel B. Ravicher (DR1498) Public Patent Foundation (PUBPAT) Benjamin N. Cardozo School of Law 55 Fifth Ave., Suite 928 New York, NY 10003 (212) 790-0442 Christopher A. Hansen (CH6776) Aden Fine (AF5241) Lenora M. Lapidus (LL6592) Sandra S. Park (SP6817) American Civil Liberties Union Foundation 125 Broad Street 18th Floor New York, NY 10004 (212) 549-2606 Dockets.Justia.com TABLE OF CONTENTS TABLE OF AUTHORITIES ............................................................................................. iii INTRODUCTION AND STATEMENT OF FACTS .........................................................1 ARGUMENT.......................................................................................................................7 I. CLAIM CONSTRUCTION OF THE PATENT CLAIMS IN SUIT ..........7 A. The Legal Framework............................................................................7 B. The Claim Language..............................................................................9 1. Claims to "isolated DNA" (`282 patent claims 1, 2,5, 6 and 7; `473 patent claim 1; and `492 patent claims 1, 6, and 7 ............9 2. Claims to methods of "comparing" or "analyzing" (`282 patent claim 20; `999 patent claim 1; `001 patent claim 1; `441 patent claim 1; and `857 patent claims 1 and 2........................15 II. HUMAN GENETIC SEQUENCES AND THE SCIENTIFIC INQUIRY OF LOOKING AT A GENE OR COMPARING TWO HUMAN GENES CONSTITUTE NATURAL PHENOMENA, LAWS OF NATURE, AND ABSTRACT IDEAS AND THUS ARE NOT PATENTABLE SUBJECT MATTER UNDER 35 U.S.C. § 101 .........................................................19 A. The BRCA1/2 genes and their mutations are natural phenomena, products of nature, and manifestations of laws of nature ....................20 1. The claimed gene sequences are products of nature.............20 2. The claimed gene sequences are a manifestation of laws of nature ................................................................................26 B. A claim over any method of looking for naturally-occurring mutations in human genes that does not specify any particular method of analysis is invalid under 35 U.S.C. § 101...........................29 C. Claims over comparing two genes monopolize laws of nature and abstract ideas and thus are not patentable processes under 35 U.S.C. § 101....................................................................................30 D. Comparing the growth rates of two cells is not patentable subject matter ...................................................................................................31 i III. IV. THE PATENT CLAIMS ARE UNCONSTITUTIONAL UNDER THE FIRST AMENDMENT..............................................................................32 THE PATENT CLAIMS ARE INVALID UNDER ARTICLE 1, SECTION 8, CLAUSE 8 OF THE CONSTITUTION..............................37 CONCLUSION..................................................................................................................38 ii TABLE OF AUTHORITIES Cases American Fruit Growers, Inc. v. Brodgex Co., 283 U.S. 1 (1931).............................................................................................21, 24 American Wood Paper Co. v. Fibre Disintegrating Co., 90 U.S. 566 (1874).....................................................................................22, 24, 25 Amgen, Inc. v. Chugai Pharmaceutical Co., 927 F.2d 1200 (Fed. Cir. 2001)..............................................................................20 Ashcroft v. Free Speech Coalition, 353 U.S. 234 (2002)...............................................................................................33 Attia v. Society of the NY Hosp., 201 F.3d 50 (2d Cir. 1999).....................................................................................37 Bell Communications Research, Inc. v. Vitalink Communications Corp., 55 F.3d 615 (Fed. Cir. 1995)....................................................................................8 In re Bergstrom, 427 F.2d 1394 (C.C.P.A. 1970) .............................................................................24 In re Bilski, 545 F.3d 943 (Fed. Cir. 2008) (en banc), cert. gr. ___ U.S. ___ (2009).........29, 30 Cochrane v. Badische Anilin & Soda Fabrik, 111 U.S. 293 (1884)...................................................................................23, 24, 25 Corning Glass Works v. Sumitomo Elec. U.S.A., Inc., 868 F.2d 1251 (Fed. Cir. 1989)................................................................................7 DeMarini Sports, Inc. v. Worth, Inc., 239 F.3d 1314 (Fed. Cir. 2001)................................................................................8 Diamond v. Chakrabarty, 447 U.S. 303 (1980)....................................................................................... passim Diamond v. Diehr, 450 U.S. 175 (1981).........................................................................................26, 27 Eldred v. Ashcroft, 537 U.S. 186 (2003).........................................................................................33, 37 iii EMI Group N. Am., Inc. v. Intel Corp., 157 F.3d 887 (Fed. Cir. 1998)..................................................................................8 Epperson v. Arkansas, 393 U.S. 97 (1968).................................................................................................33 Ex Parte Latimer, 1889 Dec. Comm'r Pat. 123 (1889).......................................................................23 Funk Bros. Seed Co. v. Kalo Inoculant Co., 333 U.S. 127 (1948)....................................................................................... passim General Electric Co. v. De Forest Radio Co., 28 F.2d 641 (3rd Cir. 1928) ....................................................................................23 Gottschalk v. Benson, 409 U.S. 63 (1972)...........................................................................................27, 29 In re Grams, 888 F.2d 835 (Fed. Cir. 1989)..........................................................................29, 31 Griswold v. Connecticut, 381 U.S. 479 (1965)...............................................................................................33 Grosjean v. American Press, 297 U.S. 233 (1936)...............................................................................................34 Harper and Row v. Nation, 471 U.S. 539 (1985).........................................................................................32, 33 Hoechst Celanese Corp. v. BP Chems. Ltd., 78 F.3d 1575 (Fed. Cir. 1996)..................................................................................8 Hormone Research Found., Inc. v. Genentech, Inc., 904 F.2d 1558 (Fed. Cir. 1990)................................................................................8 In re Kubin, 561 F.3d 1351 (Fed. Cir. 2009)..............................................................................20 Kuehmsted v. Farbenfabriken of Elberfeld Co., 179 F. 701 (7th Cir. 1910) ......................................................................................25 Laboratory Corp. of America Holdings v. Metabolite Labs., Inc., 548 U.S. 124 (2006).........................................................................................19, 31 iv Mantech Envtl. Servs., Inc. v. Hudson Envtl. Serv., Inc., 152 F.3d 1368 (Fed. Cir. 1998)................................................................................8 In re Marden, 18 C.C.P.A. 1046 (C.C.P.A. 1931) ........................................................................24 In re Marden, 18 C.C.P.A. 1057 (C.C.P.A. 1931) ........................................................................24 Matsushita Elec. Industrial Co. v. Zenith Radio Corp., 475 U.S. 574 (1986).................................................................................................1 Maxtone-Graham v. Buttchaell, 631 F. Supp. 1432 (S.D.N.Y. 1986).......................................................................33 Merck & Co. v. Olin Mathieson Chemical Corp., 253 F.2d 156 (4th Cir. 1958) ............................................................................24, 25 In re Merz, 25 C.C.P.A. 1314 (C.C.P.A. 1935) ........................................................................24 In re Meyer, 688 F.2d 789 (C.C.P.A. 1982) ...............................................................................26 Netword, LLC v. Centraal Corp., 242 F.3d 1347 (Fed. Cir. 2001)................................................................................7 Nippon Electric Glass Co. v. Sheldon, 539 F. Supp. 542 (S.D.N.Y. 1982)...................................................................27, 28 O'Reilly v. Morse, 56 U.S. 62 (1853)...................................................................................................27 Palko v. Connecticut, 302 U.S. 319 (1937)...............................................................................................33 Parke-Davis & Co. v. H.K. Mulford Co., 189 F. 95 (S.D.N.Y. 1911).....................................................................................25 Parker v. Flook, 437 U.S. 584 (1978).............................................................................20, 26, 27, 32 Phillips v. AWH Corp., 415 F.3d 1303 (Fed. Cir. 2005)................................................................................9 v Prometheus Labs. v. Mayo Collaborative Services, 2008 WL 878910, No. 04 Civ. 1200 (S.D. Cal. Mar. 28, 2008), argued, No. 2008-1403 (Fed. Cir. 2008) .........................................................31, 32 Salinger v. Colting, 2009 U.S. Dist. LEXIS 56012 (S.D.N.Y. 2009)..............................................33, 38 Scott v. Harris, 550 U.S. 372 (2007).................................................................................................1 Stanley v. Georgia, 394 U.S. 557 (1969)...............................................................................................33 Union Carbide Co. v. American Carbide Co., 181 F. 104 (2d Cir. 1910) ......................................................................................25 U.S. v. Reidel, 402 U.S. 351 (1971)...............................................................................................33 United States Surgical Corp. v. Ethicon, Inc., 103 F.3d 1554 (Fed. Cir. 1997), cert. denied, 522 U.S. 950 (1997)........................7 Vitronics Corp. v. Conceptronic, Inc., 90 F.3d 1576 (Fed. Cir. 1996)..................................................................................8 WeddingChannel.com, Inc. v. Knot, Inc., 66 Fed. R. Evid. Serv. (Callaghan) 375 (2005) ...............................................7, 8, 9 Statutes 35 U.S.C. § 101.......................................................................................................... passim 35 U.S.C. § 112..................................................................................................................36 Constitutional Provisions U.S. CONST. art. I, § 8, cl. 8 .....................................................................................1, 32, 37 U.S. CONST. amend. I................................................................................................. passim Miscellaneous Authorities H.R. Rep. No. 1923, 82nd Cong., 2d Sess., 7 (1952)..........................................................22 Utility Examination Guidelines, 66 Fed. Reg. 1092 (Jan. 5, 2001).........................4, 10, 24 vi INTRODUCTION AND STATEMENT OF FACTS This case challenges the legality and constitutionality of certain patent claims that seek to patent natural ("wild type") human genes, mutations in those genes caused by nature, and correlations between those mutations and an increased risk of breast or ovarian cancer, a correlation also caused by nature.1 These patent claims violate the Patent Act, 35 U.S.C. § 101, because they are not patentable subject matter. They also constitute patents on thought, knowledge, and ideas in violation of the First Amendment. Because they patent basic scientific principles, not inventions or discoveries, they have impeded rather than advanced science and thus also violate the U.S. Constitution, Article 1, Section 8, Clause 8 (the intellectual property clause). Plaintiffs include four prominent, national organizations including pathologists, clinical laboratory scientists, other medical professionals, and researchers, with a combined membership of over 150,000 members. SMF ¶¶ 1-4.2 Plaintiffs also include six of the nation's preeminent geneticists. SMF ¶¶ 5-10. In addition, two genetic counselors, two breast cancer and women's health advocacy organizations, and six individual women are plaintiffs. SMF ¶¶ 11-20. Defendants include the U.S. Patent and Trademark Office ("USPTO"), which granted these patents pursuant to official written policies and practices permitting the patenting of natural human genes, naturally mutated genes, and the correlations created by nature between mutated genes and an increased risk of disease. Defendants also include Myriad Genetics and the University of Utah Research Foundation, the exclusive licensee and owner of the patents. 1 The patent claims being challenged are identified in the Complaint ¶¶ 32, 55-80. The patents themselves are submitted with Plaintiffs' Motion for Summary Judgment. 2 A complete list of all of the material facts is contained in the Statement of Material Facts (SMF) filed pursuant to Local Rule 56.1. As required by the Rule, each paragraph in the SMF includes a supporting citation to one or more declaration or other document, filed herewith. 1 Each defendant has moved to dismiss on procedural grounds, and plaintiffs have filed oppositions to those motions. This memorandum is filed in support of plaintiffs' separate motion for summary judgment. Summary judgment shall be granted if the papers show that "there is no genuine issue as to any material fact and that the movant is entitled to judgment as a matter of law." Fed. R. Civ. Pro. 56(c). "[F]acts must be viewed in the light most favorable to the nonmoving party only if there is a `genuine' dispute as to those facts." Scott v. Harris, 550 U.S. 372, 380 (2007). "Where the record taken as a whole could not lead a rational trier of fact to find for the nonmoving party, there is no genuine issue for trial." Matsushita Elec. Industrial Co. v. Zenith Radio Corp., 475 U.S. 574, 587 (1986) (internal quotation marks omitted). Every human body contains genes that determine, in part, the structure and functions of the body. D. Sulston ¶¶ 10-11;3 D. Mason ¶ 4; SMF ¶¶ 40-41. Genes are created by nature. D. Sulston ¶ 10; D. Mason ¶ 33; D. Chung ¶ 25; D. Ledbetter ¶ 27; D. Leonard ¶ 15. Through a natural process in the body, the genes instruct the body to create proteins and those proteins do the work of the body. D. Mason ¶¶ 7, 11-12; D. Sulston ¶ 17. Although every person has genes, and there is enormous similarity between the genes of one individual and another, sometimes genes become altered. SMF ¶ 51. These alterations can be inherited or can occur after birth, but in both instances it is nature that causes the alterations. D. Sulston ¶¶ 19, 27; D. Mason ¶¶ 1417; D. Chung ¶ 10; D. Ledbetter ¶ 26; SMF ¶¶ 51-54, 60. Some of the alterations appear to be unimportant. Others correlate with an increased risk of disease or disorder and are called mutations. For others, the significance of the alteration is unknown ("variant of unknown significance"). D. Mason ¶ 19. The significance of the alteration is created entirely by nature. D. Sulston ¶ 27; D. Chung ¶ 10; D. Mason ¶ 20; D. Ledbetter ¶ 26. The designation "D. ____" refers to the declaration of the identified individual attached to Plaintiffs' Motion for Summary Judgment. 3 2 Because some alterations are of clinical significance, it is useful for pathologists, clinical laboratory scientists, other medical professionals, and researchers4 to look at a particular person's genes to see if he or she has alterations known to be of clinical significance. D. Sulston ¶ 18; D. Mason ¶¶ 21, 23; D. Chung ¶ 10; D. Swisher ¶¶ 23-26; SMF ¶¶ 55-58. This process is called genetic testing. There are a variety of methods by which medical professionals and researchers can examine genes, including sequencing. D. Sulston ¶¶ 20-21, 23, 25; D. Mason ¶¶ 24-30; D. Chung ¶ 10; D. Swisher ¶¶ 23-24; D. Kant ¶ 5; D. Ledbetter ¶¶ 21-22. Thousands of medical professionals and researchers around the world sequence genes every day, and the processes by which gene sequencing is done are not at issue in this case. D. Sulston ¶¶ 21-22; D. Chung ¶¶ 10-11; D. Ostrer ¶¶ 4, 8-9; D. Hegde ¶¶ 6-7; D. Hubbard ¶¶ 3-6; D. Mason ¶¶ 22, 31; D. Ledbetter ¶¶ 9-10, 22. At the end of the sequencing process, the medical professional or researcher has a long string of four letters (A, C, T, and G) that correspond to the four nucleotides (adenine, cytosine, thymine, and guanine) that form the basic elements of DNA and genes. D. Sulston ¶¶ 15-16; D. Mason ¶¶ 13, 23; D. Chung ¶ 10; SMF ¶ 55. For example, claim 2 of patent `282 is for DNA with "the nucleotide sequence set forth in SEQ ID No. 1." SEQ ID No. 1 consists of 5914 nucleotide base pairs and functionally begins with ATGGAT. This nucleotide sequence represents the human gene known as BRCA1. After sequencing, the clinician or scientist looks to see if there are variants. For example, claim 7 (a) of patent `282 claims the BRCA1 gene in which there is a variant consisting of a "T at nucleotide position 4056." In SEQ ID. No. 1, Many professionals are affected by the patent claims at issue in this case. They include molecular pathologists, geneticists (molecular, biochemical, clinical, and cytogenic), genetic counselors, research doctors and scientists, physicians, medical technologists, laboratory professionals, and other health care professionals. Hereinafter, the phrase "medical professionals and researchers" is intended as a short-hand reference to encompass all of those who seek to take actions in their professional capacity but are prevented from doing so by the patent claims at issue in this case. 4 3 position 4056 is ordinarily a C. Nature sometimes causes that C to be changed to a T. The patent claim is over the DNA as changed by nature. D. Sulston ¶ 27; D. Chung ¶ 10; D. Mason ¶ 20; D. Ledbetter ¶ 26; SMF ¶¶ 86-100. Several of the claims at issue in this case consist essentially of looking at genes. SMF ¶¶ 101-112. For example, claim 1 of patent `999 claims the act of looking at the patented gene. It does not specify or claim any particular method of looking at the gene. The only unique part of this claim is that the gene being looked at is the BRCA1 gene. Claim 1 of patent `001 involves comparing a natural gene, such as that patented by claim 2 of `282, with a sample from a patient to see if variants exist. Again, the claim does not specify or claim any particular method of obtaining or comparing the sequences; it simply covers the act of looking at the two sequences and concluding they are the same or different. Claim 2 of patent `857 similarly involves comparing two gene sequences, but at the end, the person concludes not only that the sequences are different (if they are) but that the sequence does or does not correlate with an increased risk of breast and/or ovarian cancer. Although the sequences are dictated by nature, the variants are dictated by nature, and the significance of the variants is dictated by nature, the USPTO has a policy and practice of issuing such patents. Utility Examination Guidelines, 66 Fed. Reg. 1092 (Jan. 5, 2001). For patents on the genes themselves, the USPTO's theory is that the genes involved have been "isolated," by which the USPTO means that they have been removed from the body and separated from surrounding cellular material. Id. The claims in this case describe the gene being patented as "isolated" and the gene patents in this case were granted pursuant to the USPTO's policy. "Isolation" means nothing more than a gene that has been removed from the body and separated from surrounding cellular material, and such a gene is functionally and informationally 4 identical to that in the body. D. Sulston ¶¶ 16-17, 26-27; D. Mason ¶¶ 23, 29, 32, 33; D. Chung ¶ 10; SMF ¶¶ 64-65. For example, claim 1 of patent `282 is for "isolated DNA coding for a BRCA1 polypeptide, said polypeptide having the amino acid sequence set forth in SEQ ID No. 2." But the gene as it exists in the body codes for (creates) the exact same BRCA1 polypeptide (protein). D. Sulston ¶¶ 11, 14-15; D. Mason ¶¶ 7, 11-12. Isolating the gene does not change its function. SMF ¶¶ 95-96. For some of the patent claims, defendants may assert additionally that they have transformed the gene from DNA into cDNA (complementary DNA) and it is thus a new thing. For example, SEQ ID No. 1, referred to in claim 2 of patent `282 claims cDNA. cDNA is functionally and informationally identical to DNA. D. Sulston ¶¶ 16-18, 26-27; D. Mason ¶¶ 29, 32-33; D. Chung ¶ 10. Although there are certain structural differences, such as removal of the regions that are not used in creating the protein, the cDNA structure simply mirrors the RNA structure in the body, both of which are dictated by nature. D. Mason ¶¶ 29, 32. Moreover, the structural differences are irrelevant to the function of the gene in the body or in the lab or when used by medical professionals or researchers to determine if the gene has variants of clinical significance. Id.5 The patent claims in this case have had a negative impact on both breast and ovarian cancer research and clinical practice. D. Sulston ¶ 37-38; D. Cho ¶ 24. The patent claims permit defendants to preclude all research into genes known to correlate with an increased risk of breast and/or ovarian cancer. The patent claims have deterred research into this area critical for women's health. Id. The patent claims have also prevented other labs from looking at the genes Additional details concerning genes, gene variants and mutations, gene sequencing, and gene analysis are contained in SMF ¶¶ 40-85 and the declarations cited therein. Additional details concerning the patent claims at issue in this case and their scope are contained in SMF ¶¶ 86-124, the declarations cited therein, and in section I.B. below. 5 5 involved. See, e.g., D. Kazazian ¶¶ 4-7; D. Ganguly ¶¶ 4-11; D. Chung ¶ 15; D. Hegde ¶ 10; D. Matloff ¶ 5; D. Ostrer ¶¶ 4-7, 9; D. Swisher ¶ 28; D. Hubbard ¶¶ 7-8; D. Kant ¶ 6; D. Ledbetter ¶¶ 13, 18; D. Reich ¶¶ 3, 5.6 In some instances, the effect has been devastating, as defendants utilized methods of looking at the genes over a period of years that failed to identify all variants of clinical significance and advised women that no deleterious mutations were found, when other methods could have been utilized that could have found additional mutations. See D. Limary ¶ 7; D. Thomason ¶ 6; D. Raker ¶¶ 7-8; D. Swisher ¶¶ 25-27. Defendants do not share the data gathered as a result of their monopoly with other researchers, which means that advances in understanding the significance of variants, advances that could save women's lives, have been slowed. D. Swisher ¶¶ 15-21; D. Chung ¶¶ 20-22; D. Ostrer ¶¶ 12-13; D. Limary ¶ 8; D. Sulston ¶¶ 36, 38; D. Matloff ¶ 9; D. Ledbetter ¶ 20. Clinical practice has also been harmed. Many women cannot afford the tests. D. Ceriani ¶¶ 5-7; D. Fortune ¶¶ 4-5; D. Thomason ¶ 8; D. Raker ¶¶ 7-11; D. Reich ¶¶ 6, 8, 10, 13; D. Kazazian ¶ 8; D. Matloff ¶¶ 7, 12, 14; D. Ostrer ¶ 8. Further, women cannot get a second opinion to confirm the accuracy of the testing or the meaning of the results. D. Girard ¶¶ 5-9; D. Ceriani ¶¶ 9, 11; D. Fortune ¶ 7; D. Ostrer ¶ 11; D. Swisher ¶¶ 32-33. No other diagnosticians can evaluate or ensure the quality of the testing done by defendants by attempting to replicate it. D. Chung ¶ 23; D. Ledbetter ¶ 23; D. Reich ¶ 9; D. Ostrer ¶ 11. In addition, Myriad refuses to do some critical tests. D. Chung ¶ 24. Labs have been deterred from developing new tests as a result of the patent. D. Cho ¶ 10; D. Ledbetter ¶¶ 14-15.7 Additional details concerning the enforcement of the patents are contained in SMF ¶¶ 125-141 and the declarations cited therein. 7 Additional details concerning the harms caused by these patent claims are contained in SMF ¶¶ 142-210 and the declarations cited therein. 6 6 The patent claims in this case cover products of nature, laws of nature, and abstract ideas, knowledge and even thought. These patents should never have been granted. The effect has been harmful for science, medicine, and women's health. The patents should be declared invalid. ARGUMENT I. CLAIM CONSTRUCTION OF THE PATENT CLAIMS IN SUIT A. The Legal Framework Patent analysis involves two steps. "In the first step the court determines the proper construction of the patent claims by establishing the scope and boundaries of the subject matter that is patented, as a matter of law, and in the second step the trier of fact determines issues of validity...." WeddingChannel.com, Inc. v. Knot, Inc., 66 Fed. R. Evid. Serv. (Callaghan) 375, 2005 WL 165286, at *1 (S.D.N.Y. 2005) (citing Markman v. Westview Instruments, Inc., 52 F.3d 967, 976 (Fed. Cir. 1995) (en banc), aff'd, 517 U.S. 370, 384-85 (1996)). "A claim in a patent provides the metes and bounds of the right which the patent confers on the patentee to exclude others from making, using, or selling the protected invention." Corning Glass Works v. Sumitomo Elec. U.S.A., Inc., 868 F.2d 1251, 1257 (Fed. Cir. 1989). The purpose of construing patent claims is to define the scope of the coverage of the claim by interpreting the words and terms of art used as they would be understood at the time the claim was made by one reasonably skilled in the relevant art. Claim construction is "the judicial statement of what is and is not covered by the technical terms and other words of the claims." Netword, LLC v. Centraal Corp., 242 F.3d 1347, 1352 (Fed. Cir. 2001); see also United States Surgical Corp. v. Ethicon, Inc., 103 F.3d 1554, 1568 (Fed. Cir. 1997), cert. denied, 522 U.S. 950 (1997). 7 In determining the proper construction of a claim, courts generally rely on two broad categories of evidence: (1) intrinsic evidence (i.e., the patent claims, the patent specifications, and the prosecution history), and (2) extrinsic evidence (i.e., expert and inventor testimony, dictionaries, treatises, and all other evidence external to the text of the patent and the prosecution history.) 2005 WL 165286 at *2; See Markman, 52 F.3d at 979-80. A court should examine the intrinsic evidence first, as it is "the most significant source of the legally operative meaning of disputed claim language." Vitronics Corp. v. Conceptronic, Inc., 90 F.3d 1576, 1582 (Fed. Cir. 1996). A court should look to extrinsic evidence only where necessary to resolve any ambiguities in a disputed claim term, and where the court requires assistance in understanding the technical aspects of the relevant art. See DeMarini Sports, Inc. v. Worth, Inc., 239 F.3d 1314, 1323 (Fed. Cir. 2001) (citing Mantech Envtl. Servs., Inc. v. Hudson Envtl. Serv., Inc., 152 F.3d 1368, 1373 (Fed. Cir. 1998); EMI Group N. Am., Inc. v. Intel Corp., 157 F.3d 887, 892 (Fed. Cir. 1998)). In examining the intrinsic evidence, a court should look first to the plain language of the claim itself. WeddingChannel.com, Inc., 2005 WL 165286 at *3 (citing, e.g., Bell Communications Research, Inc. v. Vitalink Communications Corp., 55 F.3d 615, 619-20 (Fed. Cir. 1995)). "Although words in a claim are generally given their ordinary and customary meaning, a patentee may choose to be his own lexicographer and use terms in a manner other than their ordinary meaning, as long as the special definition of the term is clearly stated in the patent specification or file history." Vitronics, 90 F.3d at 1582 (citing Hoechst Celanese Corp. v. BP Chems. Ltd., 78 F.3d 1575, 1578 (Fed. Cir. 1996); Hormone Research Found., Inc. v. Genentech, Inc., 904 F.2d 1558, 1563 (Fed. Cir. 1990)). As a result, "it is always necessary to review the specification to determine whether the inventor has used any terms in a manner inconsistent with their ordinary meaning." Vitronics, 90 F.3d at 1582; see also Markman, 52 8 F.3d at 979 (stating that "the description may act as a sort of dictionary, which explains the invention and may define terms used in the claims"). Shortly after this Court issued its WeddingChannel.com opinion, an en banc Federal Circuit confirmed this legal framework for claim construction. Phillips v. AWH Corp., 415 F.3d 1303 (Fed. Cir. 2005) (en banc). B. The Claim Language At issue in this case are 15 claims across 7 patents. The claims can be organized into two groups: (i) composition of matter claims for "isolated DNA," and (2) method claims for "comparing" or "analyzing." The table below sets forth all of the claims in suit divided into these two groups. The discussion below is based on what the claim terms would have meant to one of ordinary skill in the art at the time of application for the patents (presumed to be August 1994 for the '282, '473, '999, '001 and '441 patents and December 1995 for the '492 and '857 patents). D. Grody ¶¶ 6-7; D. Leonard ¶¶ 26-27. U.S. Patent No. 5,747,282 ("the '282 patent") 5,693,473 ("the '473 patent") 5,709,999 ("the '999 patent") 5,710,001 ("the '001 patent") 5,753,441 ("the '441 patent") 5,837,492 ("the '492 patent") 6,033,857 ("the '857 patent") 1, 6, 7 1, 2 Composition Claims 1, 2, 5, 6, 7 1 1 1 1 Method Claims 20 9 1. Claims to "isolated DNA" ('282 patent claims 1, 2, 5, 6 and 7; '473 patent claim 1; and '492 patent claims 1, 6 and 7) Claim 1 of the '282 patent is representative of the group of composition of matter claims and reads: 1. An isolated DNA coding for a BRCA1 polypeptide, said polypeptide having the amino acid sequence set forth in SEQ ID NO:2. Several of the terms found in this claim merit discussion. "DNA" The term "DNA" means a sequence of nucleic acids, also referred to as nucleotides. Each nucleotide is one of four possibilities: A, C, T or G. "DNA" is, thus, a "nucleotide sequence" or a "polynucleotide," although DNA is not synonymous with those terms, as not all polynucleotides are DNA, but all DNA is a polynucleotide. Determining the precise arrangement of A's, C's, T's and G's in a polynucleotide, such as DNA, is called "sequencing." D. Grody ¶¶ 1-12; D. Leonard ¶¶ 33-35. "isolated"; "isolated DNA" The term "isolated DNA" means a fragment of DNA substantially separated from other cellular components and other DNA. There were several known techniques for performing such separation at the time, so this term is not inherently limited to any particular method of "isolation." The specification of the '282 patent adopts this definition. '282 patent, col. 19, ll. 8-18. D. Grody ¶¶ 13-15; D. Leonard ¶¶ 33-35. "coding for" The term "coding for" means DNA that naturally translates into amino acids according to the well known genetic code. "Coding for" is synonymous with "encodes." A set of three nucleotides is known as a "codon" and individual codons naturally translate into one of twenty standard amino acids. A string of amino acides is called a "polypeptide." Nature determines which codons translate into which amino acids and when this genetic code was cracked it was heralded as a monumental scientific breakthrough. Thus, a DNA "codes for" a 10 certain polypeptide when it has a nucleotide sequence that will naturally translate into that polypeptide sequence. It is known that multiple codons translate into the same amino acid, so there can be multiple versions of DNA that "code for" the same polypeptide. It is also known that some portions of nucleotide sequences do not actually code for any amino acid. The specification of the '282 patent adopts this definition. '282 patent, col. 19, ll. 1-5. D. Grody ¶¶ 16-18; D. Leonard ¶¶ 36-38. "BRCA1" The term "BRCA1" refers to a particular fragment of DNA found on chromosome 17 that relates to a person's predisposition to develop breast and ovarian cancer. This particular fragment of DNA is referred to as "the BRCA1 gene." The specification of the '282 patent adopts this definition. '282 patent, col. 1, ll. 21-22. D. Grody ¶¶ 19-21; D. Leonard ¶¶ 39-41. "polypeptide"; "amino acid sequence" The term "polypeptide" means a string of amino acids. Thus, the terms "polypeptide" and "amino acid sequence" are synonymous. The specification of the '282 patent adopts this definition. '282 patent, col. 21, ll 3-5. D. Grody ¶¶ 25-27; D. Leonard ¶¶ 45-47. "having the amino acid sequence" The phrase "having the amino acid sequence" inherently means "having all of but no more than the amino acid sequence," because interpreting that phrase to allow for more than just the identified amino acid sequence would result in it encompassing up to an entire human genome, which would defeat the purpose of identifying the specific sequence. Similarly, to construe the phrase to include less than the entire identified sequence would potentially leave out important components, which could have substantial functional effects, as a partial amino acid sequence can and usually does function much differently than the complete sequence from which it is taken. D. Grody ¶¶ 28-30; D. Leonard 11 ¶¶ 48-50. "SEQ ID NO:2" This term has no ordinary meaning. Rather, it is a generic phrase that refers to a specific sequence given elsewhere, usually somewhere in the document making the reference. The specification of the '282 patent sets forth what is identified as "SEQ ID NO:2" in a "Sequence Listing" section in the back. '282 patent, cols. 79-90. The sequence is an "amino acid" (i.e. polypeptide) sequence having a total of 1863 amino acids. D. Grody ¶¶ 31-33; D. Leonard ¶¶ 51-53. Claim 2 of the '282 patent depends from claim 1 and adds the limitation "wherein said DNA has the nucleotide sequence set forth in SEQ ID NO:1." As discussed above, it is possible for there to be several DNA polynucleotide sequences that code for the same amino acid / polypeptide sequence. As such, claim 1 could cover a number of isolated DNA's, because it is only limited to DNA that codes for a particularly given amino acid sequence. Claim 2, on the other hand, depends from claim 1 and identifies a specific DNA polynucleotide sequence. Therefore, there is only one polynucleotide sequence that is covered by claim 2 and it is identified in the claim as SEQ ID NO:1, which is set forth in the "Sequence Listing" section in the back of the specification. '282 patent, col. 67-80. The sequence is a "nucleic acid" sequence having 5,914 nucleotides (the patent uses the term "base pairs", which is synonymous with nucleotide for double stranded sequences like SEQ ID NO:1). Claims 5 and 6 of the '282 patent claim an "isolated DNA having at least 15 nucleotides of the DNA of" claims 1 and 2 respectively. As discussed above, claim 1 is directed to an isolated DNA that codes for an amino acid sequence having 1863 amino acids. Because it takes three nucleotides to code for an amino acid, the isolated DNA of claim 1 must have at least 5,589 nucleotides. Thus, claim 5, directed to "isolated DNA having at least 15 nucleotides of the DNA 12 of claim 1" means any 15+ nucleotide portion of an isolated DNA that satisfies claim 1. These portions could have 15, 16, 17, etc. nucleotides and, thus, claim 5 is a much broader claim than claim 1, because there are a large number of portions of DNA satisfying claim 1 that could have at least 15 nucleotides. Similarly, claim 6, directed to "isolated DNA having at least 15 nucleotides of the DNA of claim 2," would also be much broader, because there are a large number of portions of that polynucleotide sequence that have at least 15 nucleotides, because the DNA of claim 2 has 5,914 nucleotides. Claim 7 of the '282 patent is an independent claim directed to isolated DNA that contains the polynucleotide sequence set forth in SEQ ID NO:1 except for having one of a set of identified differences (a substitution of one nucleotide for another at a particular location, an additional nucleotide at a particular location, or a deletion of certain nucleotides at a particular location). In essence, the isolated DNA in this claim is exactly the same as that claimed in claim 2, except for having one of four identified differences. Claim 1 of the '473 patent is an independent claim and reads: 1. An isolated DNA comprising an altered BRCA1 DNA having at least one of the alterations set forth in Tables 12A, 14, 18 or 19 with the proviso that the alteration is not a deletion of four nucleotides corresponding to base numbers 4184-4187 in SEQ. ID. NO:1. "altered"; "alterations" This term means being different from the most common form. With respect to DNA, the most common form of a gene is known as the "wild-type." Any persons who have differences in their genes from the "wild-type" are said to have "alterations" or "an altered gene." D. Grody ¶¶ 37-39; D. Leonard ¶¶ 57-59. Thus, claim 1 of the '473 patent is directed to isolated BRCA1 DNA that has at least one of a list of specified differences from the normal or "wild-type" BRCA1 DNA. Those differences are set forth in the specification of the '473 patent in the cited tables. '473 patent, col. 61, ll. 1-5 13 (Table 12A), col. 66, ln.15 col.67, ln. 20 (Table 14), col. 69, ll. 1-51 (Tables 18 and 19). While the claim does not expressly identify a sequence listing to define the term "BRCA1 DNA," the specification of the '473 patent states that, "the coding sequence for a BRCA1 polypeptide is shown in SEQ ID NO:1." '473 patent, col. 19, ll. 43-44. Thus, claim 1 of the '473 is virtually identical to claim 7 and the '282 patent, except for listing a different set of genetic alterations (claim 7 of the '282 patent identifies four alterations, while claim 1 of the '473 patent identifies several tables that each contain a number of alterations). Claim 1 of the '492 patent is an independent claim that is virtually identical to claim 1 of the '282 patent discussed above. The only differences are that claim 1 of the '492 is directed to "BRCA2," not "BRCA1," and the amino acid sequence set forth as SEQ ID NO:2 in the '492 patent is not the same as that set forth in the '282 patent (this is because BRCA1 and BRCA2 are completely different genes existing at entirely different places on our chromosomes). "BRCA2" The term "BRCA2" was known at the time to refer to a particular fragment of DNA found on chromosome 13 that related to a person's predisposition to develop breast and ovarian cancer. This particular fragment of DNA is referred to as "the BRCA2 gene." The specification of the '492 patent adopts this definition. '492 patent, abstract. D. Grody ¶¶ 22-24; D. Leonard ¶¶ 42-44. Claim 6 of the '492 patent is an independent claim and reads: 6. An isolated DNA molecule coding for a mutated form of the BRCA2 polypeptide set forth in SEQ ID NO:2, wherein said mutated form of the BRCA2 polypeptide is associated with susceptibility to cancer. "mutated"; "mutation" This term means an alteration or altered substance that causes or results in a meaningful (typically harmful) effect. Many alterations are benign and have no effect on the operation of the cell within which they exist. Other alterations do have an effect 14 (usually harmful) on the operation of the cell within which they exist. These types of alterations are typically called "mutations." Mutations can exist in either a nucleotide sequence or an amino acid sequence. D. Grody ¶¶ 46-48; D. Leonard ¶¶ 66-68. Claim 6 of the '492 patent, therefore, broadly claims any and all nucleotide sequences that would translate into any BRCA2 amino acid sequence that correlates to a greater likelihood of getting cancer because, unlike the claims discussed above, this claim is not limited to any particular list of alterations. Claim 7 of the '492 patent depends from claim 6 and adds the limitation, "wherein the DNA molecule comprises a mutated nucleotide sequence set forth in SEQ ID NO:1." Because multiple DNA polynucleotide sequences can code for the same amino acid sequence, claim 6 could cover multiple DNA nucleotide sequences. Claim 7 limits that range to just one specific nucleotide sequence, that set forth in the '492 patent as SEQ ID NO:1. However, there are multiple ways in which that nucleotide sequence can be "mutated" and still code for a mutated form of BRCA2 polypeptide. Thus, claim 7 is not limited to a single mutated form of that nucleotide sequence. 2. Claims to methods of "comparing" or "analyzing" ('282 patent claim 20; '999 patent claim 1; '001 patent claim 1; '441 patent claim 1; and '857 patent claims 1 and 2) Claim 1 of the '999 patent is representative of the group of "method" claims. It is independent and reads: 1. A method for detecting a germline alteration in a BRCA1 gene, said alteration selected from the group consisting of the alterations set forth in Tables 12A, 14, 18 or 19 in a human which comprises analyzing a sequence of a BRCA1 gene or BRCA1 RNA from a human sample or analyzing a sequence of BRCA1 cDNA made from mRNA from said human sample with the proviso that said germline alteration is not a deletion of 4 nucleotides corresponding to base numbers 41844187 of SEQ ID NO:1. 15 This claim relates to a method for determining whether there is an alteration in a BRCA1 gene and includes only one step: "analyzing a sequence." This is because a BRCA1 gene, a BRCA1 RNA from a human sample, and a BRCA1 cDNA made from mRNA from said human sample all have the same polynucleotide sequence. D. Grody ¶¶ 52-57; D. Leonard ¶¶ 72-77. The "analyzing" performed in this claim merely requires one to look at the sequence and see if it contains one of the identified alterations. D. Grody ¶¶ 43-45; D. Leonard ¶¶ 63-65. This claim presumes that the sequence is already provided, as it does not include a step of first sequencing the gene before "analyzing" it. The tables referenced in the claim are all set forth in the specification of the '999 patent and contain lists of alterations. '999 patent, col. 61, ll. 36-51 (Table 12A), col. 66, ln.32 col.67, ln. 38 (Table 14), col. 69, ln. 31 col. 70, ln. 22 (Tables 18 and 19). "germline" This term means hereditary, or received from genetic parents. D. Grody ¶¶ 49-51; D. Leonard ¶¶ 69-71. Thus, claim 1 of the '999 patent is nothing more than a method for detecting whether a particular BRCA1 gene has an inherited alteration that is listed in one of the referenced tables. Claim 1 of the '001 patent is a similar independent claim. It relates to a method for determining whether a tumor sample from a human contains a BRCA1 alteration and includes only one step: "comparing a first sequence ... with a second sequence" to see if there is a difference between them and, if there is, then concluding that such "indicates a somatic alteration" in the tumor sample. The "comparing" performed in this claim merely requires one to look at the two sequences, see if there is a difference between them and then conclude that a difference means there is an alteration. D. Grody ¶¶ 40-42; D. Leonard ¶¶ 60-62. This claim presumes the sequences are already provided, as it does not include a step of first "sequencing" 16 the BRCA1 gene, BRCA1 RNA, or cDNA made from mRNA, or otherwise acquiring the nucleotide sequences. D. "somatic" This term means created within the body, not inherited. D. Grody ¶¶ 58-60; D. Leonard ¶¶ 78-80. It is the opposite of "germline." Somatic alterations are created within the body at a particular place, and often lead to tumors at that location. As such, other parts of the body will not have the somatic alteration. Thus, claim 1 of the '001 patent is nothing more than a method for detecting if a tumor sample from a human contains an altered BRCA1 gene that was created within the body, not inherited, by comparing the BRCA1 sequence from the tumor with the BRCA1 sequence from a non-tumor sample from the same person. Claim 1 of the '441 patent and Claim 1 of the `857 patents are similar independent claims, differing only as to BRCA1 (`441) or BRCA2 (`857). They relate to a method for determining whether a human has an inherited BRCA1 genetic alteration and include only one step: "comparing" a nucleotide sequence from the human to what is known to be the "wild-type" nucleotide sequence. D. Grody ¶¶ 46-48; D. Leonard ¶¶ 66-68. The "comparing" performed in these claims merely requires one to look at the two sequences, see if there is a difference between them and then conclude that a difference means there is an alteration. These claims presume the sequences are already provided, as they do not include a step of first "sequencing" the BRCA1/2 gene, BRCA1/2 RNA, or cDNA made from mRNA, or otherwise acquiring the nucleotide sequences. Thus, claim 1 of the '441 patent and claim 1 of the `857 patent are nothing more than a method for determining if a person has an altered BRCA1 or BRCA2 gene by comparing his or her inherited BRCA1 or BRCA2 gene to that which is previously known to be the normal or most common typical version of the gene. 17 "allele" This term means one member of a pair of genes at a specific location on a chromosome. Double stranded DNA has one allele on each strand at each location. Thus, a DNA could have a wild-type allele and a mutated allele at the same location. When this occurs, one of the alleles may be dominant while the other is recessive. Thus, for the purposes of the patents in suit, the term "allele" and the term "gene" are practically synonymous. D. Grody ¶¶ 46-48, 61-63; D. Leonard ¶¶ 66-68, 81-83. Claim 2 of the '857 patent is a similar independent claim. It relates to a method for determining if a human is predisposed to getting breast cancer and has only one step: "comparing" the BRCA2 nucleotide sequence from the human with the known nucleotide sequence for the normal, most-typical version of the BRCA2 gene and concluding that a difference between them means the human has an alteration that predisposes him or her to breast cancer. The "comparing" performed in this claim merely requires one to look at the two sequences, see if there is a difference between them and then conclude that the person has an alteration that predisposes him or her to breast cancer. This claim presumes the sequences are already provided, as it does not include a step of first "sequencing" the BRCA2 gene or its mRNA, or otherwise acquiring the nucleotide sequences. Claim 20 of the '282 patent is an independent claim that relates to a method for determining whether a potential cancer therapeutic actually is a cancer therapeutic and includes only four steps: (i) growing a cell containing an altered BRCA1 gene that is known to predispose the cell to cancer in the presence of the potential therapeutic; (ii) growing the same cell in the absence of the potential therapeutic; (iii) calculating the respective growth rates of those two cells; and, (iv) concluding that a slower growth rate for the cell in the presence of the potential therapeutic indicates the compound is indeed a cancer therapeutic. The growth of cells in the 18 presence or absence of a potential therapeutic is a natural process and does not result in a transformation of the cells in any way that would not occur naturally. Determining the growth rate of such cells is a simple task. The final step is a purely mental conclusion of comparing two growth rates to determine if they are different and then concluding that it was the presence of the potential therapeutic that caused any such difference. D. Grody ¶¶ 34-36; D. Leonard ¶¶ 54-56. II. HUMAN GENETIC SEQUENCES AND THE SCIENTIFIC INQUIRY OF LOOKING AT A GENE OR COMPARING TWO HUMAN GENES CONSTITUTE NATURAL PHENOMENA, LAWS OF NATURE, AND ABSTRACT IDEAS AND THUS ARE NOT PATENTABLE SUBJECT MATTER UNDER 35 U.S.C. § 101. The patenting of human genes, the concept of looking at or comparing human genes, and correlations found in nature between mutated genes and an increased risk of breast and/or ovarian cancer violates long-established Supreme Court precedent that prohibits the patenting of laws of nature, physical phenomena, and abstract ideas. Diamond v. Chakrabarty, 447 U.S. 303, 309 (1980) (citations omitted). The Court has explained repeatedly that products and laws of nature and abstract ideas cannot meet the threshold for qualifying as "inventions patentable" under 35 U.S.C. § 101 because "[s]uch discoveries are `manifestations of . . . nature, free to all men and reserved exclusively to none.'" Id. quoting Funk Brothers Seed Co. v. Kalo Inoculant Co., 333 U.S. 127 (1948). "[T]he reason for the exclusion is that sometimes too much patent protection can impede rather than `promote the Progress of Science and useful Arts,' the constitutional objective of patent and copyright protection." Laboratory Corp. of America Holdings v. Metabolite Labs., Inc., 548 U.S. 124, 126-27 (2006) (J. Breyer, dissenting). Relying on this principle, the Supreme Court has rejected patent claims even when the purported invention was highly beneficial or novel, or the research and work that went into identifying it was costly or time-consuming. "The obligation to determine what type of 19 discovery is sought to be patented must precede the determination of whether that discovery is, in fact, new or obvious." Parker v. Flook, 437 U.S. 584, 593 (1978). While the Court has not yet considered the patentability of human genes, its precedents support only one conclusion: BRCA1/2 gene sequences and the thought of comparing genes are so fundamental to human nature and scientific inquiry that these patent claims cannot pass muster under section 101.8 A. The BRCA1/2 genes and their mutations are natural phenomena, products of nature, and manifestations of laws of nature. This case challenges claims over BRCA1/2 wild-type (or normal) genetic sequences and BRCA1/2 genetic sequences containing naturally-occurring mutations [collectively, "the composition claims" or "the gene sequence claims"]. Some of these claims are over genes in the exact same structure as they exist in the human body, and other claims may be limited to DNA without their non-coding sections DNA that has the exact same function and informational content as the genes as they exist in the body. All of these claims embody products and laws of nature. D. Sulston ¶¶ 10, 16-17, 19, 27; D. Ostrer ¶ 14; D. Chung ¶¶ 10, 25; D. Mason ¶¶ 20, 29, 32-33; D. Ledbetter ¶¶ 26-27; D. Leonard ¶ 15. 1. The claimed gene sequences are products of nature. Supreme Court precedent establishes that merely extracting, purifying, or changing a natural product does not render that product patent-eligible, unless a fundamentally new product is created. Because the composition claims patent genes that simply have been removed from Some lower courts have looked at gene patents without examining the patentable subject matter question under section 101. A Federal Circuit case looking at patents on the DNA sequence that encodes human erythropoietin (EPO) assumed that isolated and purified genes were patentable. Amgen, Inc. v. Chugai Pharmaceutical Co., 927 F.2d 1200 (Fed. Cir. 1991). Amgen did not engage in a section 101 analysis, but merely upheld the gene sequence claims against prior art and best mode challenges. A more recent case concluded that claims on DNA molecules encoding for a protein known as "NAIL," thought to help activate cells that can play a major role in fighting tumors, were obvious. In re Kubin, 561 F.3d 1351 (Fed. Cir. 2009). The court held that it was "obvious to try" to identify the gene sequences given the previous disclosure of a protein identical to NAIL and a method for obtaining the DNA sequence for NAIL. Id. at 1361. Neither of these cases dealt with whether genes are patentable subject matter. 8 20 other cellular materials or genes whose non-coding sections have been removed, this case law mandates the invalidation of these claims. In 1931, the Court rejected the patenting of a fruit, the skin or rind of which carried mold-resistant borax. American Fruit Growers, Inc. v. Brodgex Co., 283 U.S. 1 (1931). Although the "complete article is not found in nature," and despite the "treatment, labor and manipulation" that went into producing the fruit, the Court held that the fruit did not become an "article of manufacture" unless it "possesses a new or distinctive form, quality, or property" distinct from nature. Id. at 11. In 1948, the Court concluded that a mixture of several naturally-occurring species of bacteria was not patentable, despite the special commercial utility shown by the combination. Funk Bros. Seed Co., 333 U.S. at 128-31. Each species of bacteria in the mixture could extract nitrogen from the air for plant usage. While the patent holder had created a mixture by selecting and testing for strains of bacteria that did not mutually inhibit one another, the Court concluded that the patent holder did "not create a state of inhibition or of non-inhibition in the bacteria. Their qualities are the work of nature. Those qualities are of course not patentable." Id. at 130. Just as the fruit and the bacteria strains were works of nature, so, too, are the genes in this case. D. Jackson ¶ 34. Fully consistent with this precedent, the Court recognized the patentability of geneticallyengineered bacterium capable of breaking down crude oil in Diamond v. Chakrabarty, 447 U.S. 303 (1980). There, the "patentee has produced a new bacterium with markedly different characteristics from any found in nature and one having the potential for significant utility. His discovery is not nature's handiwork, but his own; accordingly it is patentable subject matter under § 101." Id. at 310. Unlike the gene sequences at issue here, the Chakrabarty bacterium 21 was a product that was engineered by man to serve an entirely innovative function. D. Jackson ¶ 41. Chakrabarty often has been cited for the proposition that "anything under the sun that is made by man" is patentable, id. at 309, but that phrase cannot support the notion that anything created by human effort survives section 101 scrutiny. The legislative history of the Patent Act of 1952, from which Chakrabarty only partially quotes, clearly acknowledges the statutory limitations. "A person may have `invented' a machine or a manufacture, which may include anything under the sun made by man, but it is not necessarily patentable under section 101 unless the conditions of the title are fulfilled." H.R. Rep. No. 1923, 82d Cong., 2d Sess., 6 (1952) (emphasis added). In this case, the claimed gene sequences and mutations are neither machine nor manufacture. Chakrabarty itself reaffirms that the case does not "suggest that § 101 has no limits or that it embraces every discovery . . . a new mineral discovered in the earth or a new plant found in the wild is not patentable subject matter." 447 U.S. at 309. Funk Brothers and Chakrabarty teach that the conditions of section 101 cannot be satisfied by naturally-occurring products, even when human ingenuity led to their packaging in a more useful form whose function is identical to that found in nature. "Purification" also does not make a product of nature into something patentable. Starting as early as 1894, the Supreme Court recognized that simply purifying a natural substance is insufficient to create a "new composition of matter." In American Wood Paper Co. v. Fibre Disintegrating Co., the Court held that refined cellulose, consisting of purified pulp derived from wood and vegetable, was unpatentable because it was "an extract obtained by the decomposition or disintegration of material substance." 90 U.S. 566, 570 (1874). There are many things well known and valuable in medicine or in the arts which may be extracted from divers substances. But the extract is the same, no matter from what it has 22 been taken. A process to obtain it from a subject from which it has never been taken may be the creature of invention, but the thing itself when obtained cannot be called a new manufacture. Id. at 593-94. D. Jackson ¶¶ 17-25. The principle that one cannot patent a purified product of nature was further explained in Cochrane v. Badische Anilin & Soda Fabrik, 111 U.S. 293 (1884). There, the Court rejected a patent on an artificial version of a natural red dye called alizarine that was produced by manipulating another compound through acid, heat, water, or distillation. Id. Although the artificial version of the dye was of brighter hue than observed in nature and prepared through a new, man-made process, it was unpatentable because of its similarity to the natural product. D. Jackson ¶¶ 7-16. This precedent has been applied to prohibit patents on naturally-occurring products that have been extracted, distilled, or purified. In Ex Parte Latimer, the Patent Commissioner refused to allow a patent on pine needle fibers that were better suited for textile production, even though it was necessary to remove the needle from its sheath and other resinous material. 1889 Dec. Comm'r Pat. 123, 125 (1889)("Nature made them so and not the process by which they are taken from the leaf or needle"). Similarly, the Third Circuit held that a patent applicant named Coolidge could not patent "substantially pure tungsten having ductility and high tensile strength," despite the superiority of purified tungsten over its naturally-occurring, brittle form. General Electric Co. v. De Forest Radio Co., 28 F.2d 641 (3d Cir. 1928). Naturally we inquire who created pure tungsten. Coolidge? No. It existed in nature and doubtless has existed there for centuries. The fact that no one before Coolidge found it there does not negative its origin or existence. The second part of the claim reads: `Having ductility and high tensile strength.' Did Coolidge give those qualities to `substantially pure tungsten'? We think not for it is now conceded that tungsten pure is ductile cold. If it possesses that quality now it is certain that it possessed it always. 23 Id. at 643; D. Jackson ¶¶ 38-40. General Electric confirms that a naturally-occurring substance does not transform into a synthetic product when isolated and purified, as the characteristics of a purified substance are inherent to nature rather than created by the researcher. See also In re Marden, 18 C.C.P.A. 1046 (C.C.P.A. 1931) (rejecting patent on purified uranium); In re Marden, 18 C.C.P.A. 1057 (C.C.P.A. 1931) (rejecting patent on purified vanadium); In re Merz, 25 C.C.P.A. 1314 (C.C.P.A. 1935) (rejecting patent on purified ultramarine). "[M]ere purification of known materials does not result in a patentable product," unless "the product obtained in such a case had properties and characteristics which were different in kind from those of the known product rather than in degree." Merz, 25 C.C.P.A. at 1316. The USPTO's policy of treating genes as patentable misses this important distinction. The USPTO policy allows patents on "isolated and purified" DNA that has the same sequence as a naturally occurring gene because 1) "the DNA molecule does not occur in that isolated form in nature" and 2) the purified state of synthetic DNA preparations "is different from the naturally occurring compound." 2001 Utility Guidelines at 1093. Thus, according to the PTO, one can patent a "gene excised from the natural chromosome," id., although that would simply entail removing the gene from its natural environment. If this erroneous analysis had been applied in the Supreme Court cases discussed above, then the cellulose at issue in Wood Paper, the dye of Cochrane, the fruit of American Fruit Growers, and the combination of bacteria species of Funk Brothers could have been patented because they did not occur in nature in their claimed form. Some lower courts have committed this same error by mistakenly focusing on novelty and utility rather than patentability. For example, in In re Bergstrom, 427 F.2d 1394 (C.C.P.A. 1970), the court upheld patents on purified prostaglandins as useful without citing to any case law supporting the rejection of the section 101 arguments. In Merck & Co. v. Olin Mathieson 24 Chemical Corp., 253 F.2d 156 (4th Cir. 1958), the court upheld a patent on the purified B-12 vitamin because the natural form "has no utility, therapeutically or commercially, until converted into compositions comparable to the patented products." Although apparently thinking utility the only relevant question, the Merck court did note that "[t]he claims of this patent do not reach pure, crystalline vitamin B(12)" or "vitamin B(12) compositions derived from liver or any source other than the specified fermentates." Id. at 160. It was thus interpreted not to reach all B-12, but only one type, manufactured from a single source. D. Jackson ¶¶ 35-37. All of the claims in this case reach genes from any source. Indeed, claims 6 and 7 of `492 encompass all the mutated forms of the BRCA2 gene, without specifying mutation type or location, and whether discovered at the time of the patent or in the future, by Myriad or someone else. Some of the mutations claimed by Myriad were found by others. D. Sulston ¶¶ 30-32. The court in Parke-Davis & Co. v. H.K. Mulford Co., 189 F. 95 (S.D.N.Y. 1911), also erroneously justified its finding that purified adrenaline was patentable based on its commercial utility. In reaching this conclusion, the court relied on Kuehmsted v. Farbenfabriken of Elberfeld Co., 179 F. 701 (7th Cir. 1910), and Union Carbide Co. v. American Carbide Co., 181 F. 104 (2d Cir. 1910), two inapposite cases, as both dealt with the purification of human-made chemicals that did not exist in nature. Parke-Davis also is unpersuasive in the gene patent context for scientific reasons. Whereas the human body does not possess a natural process for purifying adrenaline, the human body does possess a natural process for isolating and purifying genes. D. Jackson ¶¶ 26-29; D. Mason ¶¶ 11-12. All four Supreme Court cases (American Wood Paper, Cochrane, Funk Brothers, and Chakrabarty) hold that patentability requires more than removing a natural product from its environment and purifying it. There must be a change in function. Genes are products of nature 25 and sequencing genes does not produce something with a new function. Indeed, sequencing is designed solely to reveal the functions of the gene dictated by nature. D. Mason ¶¶ 23, 29, 32, 33; D. Sulston ¶¶ 16-17, 18, 26-27; D. Chung ¶ 10. 2. The claimed gene sequences are a manifestation of laws of nature. Patent law has long held that scientific truths and natural phenomena cannot be patented. "The Supreme Court has recognized that scientific principles and laws of nature, even when for the first time discovered, have existed throughout time, define the relationship of man to his environment, and, as a consequence, ought not to be the subject of exclusive rights to any one person." In re Meyer, 688 F.2d 789, 795 (C.C.P.A. 1982). "The rule that the discovery of a law of nature cannot be patented rests, not on the notion that natural phenomena are not processes, but rather on the more fundamental understanding that they are not the kind of `discoveries' that the statute was enacted to protect." Parker v. Flook, 437 U.S. 584, 593 (1978). Examples of nonpatentable subject matter include Newton's law of gravity, Einstein's e=mc2, and the Arrhenius equation. See Chakrabarty, 447 U.S. at 309; Diamond v. Diehr, 450 U.S. 175 (1981). The Supreme Court applied this doctrine in Funk Bros., 333 U.S. at 130: The qualities of these bacteria like the heat of the sun, electricity, or the qualities of metals, are part of the storehouse of knowledge of all men. They are manifestations of laws of nature, free to all men and reserved exclusively to none. He who discovers a hitherto unknown phenomenon of nature has no claim to a monopoly of it which the law recognizes. If there is to be invent


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Meaning and name origin
Harloe \ha(r)-loe\ as a boy's name has the meaning "army hill" and is a variant of Harlow (Old English): place name.
Harloe has 1 variant form: Harlo.
Harloe is also pronounced similarly to Harlea, Harlee, Harley, Harly and Hurlee. Another suggested similar baby name is Marloe.
Harloe is not a popular first name for males and an equally uncommon surname or last name for all people (2000 U.S. Census).
Displayed below is the baby names popularity of Harloe name for boys (2012 statistics). Compare Harloe with its variant form and related boy baby names.
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