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South Omaha Community Outreach Program
The South Omaha Community Outreach Scholarship Program at Bellevue University is designed to enroll, retain and educate residents of South Omaha and Bellevue. This culturally and economically diverse section of the greater Omaha area has many Latino and other ethnic minorities. Bellevue University's main campus is located just a few miles from South Omaha providing a small-school atmosphere close to home, work and family.
By participating in this scholarship program, students receive one-on-one advising throughout degree completion programs. Significant scholarship support and professional career development is available for traditional, non-traditional, and Accelerated Bachelor's Degree Completion Program students.
For more information on the eligibility requirements to apply for this scholarship program, please contact:
Cristina Lamas
Relationship Manager-South Omaha
(402) 557-5079
Johnna Martinez
Scholarship and Grant Manager
(402) 557-7441
For more information on applying for this scholarship, please go to:
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Please reach out to one of our Admission Counselors and they can answer any questions you have at 1-800-756-7920 (option 1). The Admissions office is open Monday through Thursday 8:00 a.m. to 8:00 p.m. (CST) and Fridays from 8:00 a.m. to 5:00 p.m. (CST).
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I have little confusion in the smoke and sanity testing.Still i didn't correct definition for this question?
what is difference b/w smoke and sanity testing?
Any one give correct definition for Smoke and sanity with examples.
Views: 673
I fail to understand why this is the most commonly asked question in testing. The distinction between the two is not generally important. In fact, it's one of the most trivial aspects of testing that I can think of, offhand, but it does point to something important.
Both smoke testing and sanity testing refer to a first-pass, shallow form of testing intended to establish whether something can perform the most basic functions. Some people call such testing "smoke testing"; others call it "sanity testing". "Smoke testing" derives from the hardware world; if you create an electronic circuit, power it up, and smoke comes out, the smoke test has failed. Sanity testing has no particular derivation that I'm aware of, other than the common dictionary definition of the word. Does the product behave in some crazy fashion? If so, it has failed the sanity test.
Do you see the similarity between these two forms of testing? Can someone make a meaningful distinction between them? Maybe someone can. If so, let them make it. If you're talking to them, and they want to make a distinction, go with it. Some organizations make a distinction between the two; some don't. If it's important in your workplace, then ask in your workplace. Otherwise, it's not important.
Here's what is important: whatever organization you go to in your testing career, people will speak a different language that has evolved as part of the culture of that organization. Some consultancies or certification mills or standards bodies claim the goal of providing "a common worldwide standard language for testing". This is as fruitless and as pointless a goal as a common worldwide standard language for humanity. Throughout history, people have developed different languages to address things that were important in their culture and society and environment. This is a good thing. This is not a bad thing.
If you find yourself in conversation with someone who asks you "Do you do X?", and you're not sure what X is by their definition, the smart reply starts with, "I may do X, but not necessarily by that name." After that,
---Michael B.
Thank you very much Michael.
Hi i came across the same confusion but i found this . i guess this distinguishes very clearly between the two.
Smoke Test:
When a build is received, a smoke test is run to ascertain if the build is stable and it can be considered for further testing.
Smoke testing can be done for testing the stability of any interim build.
Smoke testing can be executed for platform qualification tests.
Sanity testing:
Once a new build is obtained with minor revisions, instead of doing a through regression, a sanity is performed so as to ascertain the build has indeed rectified the issues and no further issue has been introduced by the fixes. Its generally a subset of regression testing and a group of test cases are executed that are related with the changes made to the app.
Generally, when multiple cycles of testing are executed, sanity testing may be done during the later cycles after through regression cycles.
Smoke testing originated in the hardware testing practice of turning on a new piece of hardware for the first time and considering it a success if it does not catch fire and smoke. In software industry, smoke testing is a shallow and wide approach whereby all areas of the application without getting into too deep, is tested.
A sanity test is a narrow regression test that focuses on one or a few areas of functionality. Sanity testing is usually narrow and deep.
A smoke test is scripted--either using a written set of tests or an automated test
A sanity test is usually unscripted.
A Smoke test is designed to touch every part of the application in a cursory way. It's is shallow and wide.
A Sanity test is used to determine a small section of the application is still working after a minor change.
Smoke testing will be conducted to ensure whether the most crucial functions of a program work, but not bothering with finer details. (Such as build verification).
Sanity testing is a cursory testing; it is performed whenever a cursory testing is sufficient to prove the application is functioning according to specifications. This level of testing is a subset of regression testing.
Smoke testing is normal health check up to a build of an application before taking it to testing in depth.
sanity testing is to verify whether requirements are met or not,
checking all features breadth-first.
Thank you very much amol
Nice, but someone somewhere will have a different meaning. Feel free to read what I wrote above.
---Michael B.
nice replay.
Nice distinction.
But as michael said, it chnages from organization to organization. we need to go along with our organization's one.

subset: commoncrawl


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Susannite : Pb4(CO3)2(SO4)(OH)2minID: WAK-UQK
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Videoconferencing has been adopted by over 75% of organizations and is common across small, medium and large environments and multiple industry verticals – adoption does not depend on company size.
Companies that have adopted videoconferencing technology are realizing average annual travel reductions of greater than 20% on average. Many are able to justify further investment based on these hard cost savings alone.
We recently polled our clients to find out where they stand on using videoconferencing for business. The results? 52% report that videoconferencing is just as effective as in-person meetings. In the words of one client: "[videoconferencing] has made travel virtually unnecessary."
Immersive telepresence solutions have created considerable buzz in the videoconferencing market, but conventional room systems and desktop clients are much more affordable, flexible and practical for the vast majority of companies.
The business videoconferencing market is highly consolidated and is largely dominated by only five major players: Cisco, LifeSize, Polycom, RADVISION and Vidyo. You can read our complete Videoconferencing Vendor Landscape to get the details on each company's videoconferencing offering – regardless of the vendor you choose for videoconferencing, planning for implementation is the key to achieving measurable benefits with satisfactory ROI.
Planning is the Key to Videoconferencing Success
Like IP voice traffic, video is a real-time network application that is highly susceptible to latency, packet loss and jitter. Enterprises that have not previously managed real-time communications risk identifying network congestion issues only after a solution is deployed.
To reduce these risks, address the following when preparing your network:
- Determine bandwidth requirements. Depending on the solution selected, the bandwidth required per single video stream can range from 256kbps to over 1Mbps for HD quality video.
- Prepare LAN environment. A managed LAN with 802.1q (VLAN tagging) and 802.1p (traffic prioritization) at Layer 2 and DiffServ at Layer 3 is essential to support optimal video performance.
- Ensure WAN performance. To support multi-site conferencing, MPLS or dedicated connectivity, allowing traffic prioritization, are a necessity.
But it's not all about the technology. It's important to look after the room equipment and design elements that contribute to the overall meeting experience. Acoustics, lighting, and display sizes are very important components of conference room and boardroom videoconferencing deployment scenarios.
Things you should take into account regarding your videoconferencing implementation:
- Acoustics. Clear audio is vital – rooms should be isolated from HVAC noise and specific treatments for interior walls and ceilings (e.g. acoustic tiles) may be warranted in some cases.
- Lighting. Ensure that shadows are minimized and avoid rooms with uncovered windows – controlled, soft lighting, positioned away from displays, is a must.
- Displays. Matching display size to average viewing distance will ensure that user engagement and visual cues are optimized.
Don't be afraid to call in the experts. Very few IT shops have specialized A/V experience on staff – using a systems integrator is often central to the success of the project.
End User Adoption is Not a Given – Invest in Training Early
End user uptake of videoconferencing tools is not a given. In fact, 49% of survey respondents indicate that their organizations are not realizing the anticipated adoption for the videoconferencing deployment. Engaging end users early in planning will help ensure that the solution selected will best meet business and team collaboration requirements.
Requiring IT personnel to setup each meeting is a weak proposition – users must be able to independently access and use the equipment in order for uptake to reach optimal levels. A comprehensive end user training plan is critical to ensuring videoconferencing usage, virtual meeting productivity and overall long-term project success.
Plan a pilot project to test the technology in your real-world scenarios. This will help ready users for wide-spread adoption, and can provide opportunities to build confidence in the technology. You should consider:
- Awareness. Showcasing videoconferencing tools and technology in the context of user information sessions can help develop user mindshare and generate interest in real-time collaboration tools.
- Support. While some users may find the tools to be intuitive, others will likely have difficulty acclimating. A pilot stage will help IT understand specific usage barriers and target training accordingly.
- Feedback. Collecting end user feedback throughout the planning process can help IT anticipate future challenges and feature requests and improve its approach to future rollout.
Understanding user collaboration requirements, actual use cases, and daily communications habits will help IT determine the right videoconferencing technology for business needs.
Integration of a videoconferencing solution with existing IT elements – directory services, calendar, UC platforms – and a comprehensive end user training strategy are critical to long term success and widespread usage in the organization.


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Facility Specific Brigg B&B's: - Dog Friendly
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U.S. President Barack Obama (R) shakes hands with Admiral Samuel Locklear as he arrives with his family for their annual Christmas and New Year vacation in Honolulu, Hawaii December 19, 2014. REUTERS/Gary Cameron (UNITED STATES - Tags: POLITICS SOCIETY MILITARY)
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i've put up a real estate website and now set up roles for users as "real estate agents ". but, now when they login they do not get the "wp-property" dashboard. only, administrator can see that part. how can i tweak the permissions to make it visible to "real estate agent" roles and "administrators"
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*May or may not contain any actual "CSS" or "Tricks".


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What are a few examples of symbolism in the book Anthem by Ayn Rand?
1 Answer | Add Yours
There are so many symbols in Anthem that one could turn to any page and find one-- it's that amazing! The whole society that Rand created in the story is symbolic of some ideology that can drive any heated political or social discussion. First, the element of light is both ideologically and temporally discussed. The society uses candles, the most simplistic forms of light, yet Equality discovers electricity. In this example, the types of light also represent the level of knowledge that a person accepts in the story. The Scholars could not accept electricity like Equality did; therefore, they could only accept the lower form of knowledge according to the rules of their society (which also limits their intellectual progression). The following is a list of other symbols and their meanings from the novel.
Uncharted Forest = freedom or uncharted life of choices and free will
Social Meetings = brainwashing forums for acceptance of the society
People's Names = Collective Nouns (singular nouns with plural meanings--just like the society.)
The Cave= this is a Yonic symbol (maternal) where most people spend time being nurtured and learn about the world.
Body language= the state of a man. Most men are hunched over, sad, and won't look into each other's eyes due to fear. But Equality walks uprightly showing his strength of mind.
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All Elena Michaels wants is to live her life as a Toronto-based freelance photographer and lover of sexy, smart ad executive Philip McAdams. Unfortunately, that's not in the cards, because Elena has a secret past: She is the world's only known female werewolf and former member of the North American Stonehaven pack. When a girl's mauled body shows up in upstate New York, Elena is once again forced to plunge back into the life of her pack, and that of her ex-lover, Clay Danvers.
Get to know the books and mythology behind Bitten.
Elena likes to find Philip in bed, but not like this.


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International Mataw-Guro Association Gathering (Phoenixville PA)
Date(s) - 07/27/2013
All Day
Kuntao Club at Franklin Commons
PHOENIXVILLE — With a gathering for a Filipino-American group slated for the last weekend of July, Mayor Leo Scoda took a request to proclaim July 27 Filipino-American Cultural Day in Phoenxville borough.
Spanning both July 27 and 28, the International Mataw-Guro Association gathering is scheduled to take place in the borough and will be hosted by Dale Yeager, the executive director of the Kuntao Club, located in Franklin Commons.
"This is one of the Top 10 Filipino-American events in the United States," Yeager told council and the mayor at a June 11 meeting. "It's actually recognized by the state department. Leadership from the Philadelphia and Chester County Filipino American Associations is set to attend as well as a former senator from the Filipino government.


text: Recorded this this afternoon. It seemed appropriate considering my current marital situation. And I might as well record now that I still have some guitars with which to record! :facepalm: Gear used: Ovation Elite T USB Blue Snowball mic Audacity One take - I don't have another one in me. MojoTwanger - MojoTwanger.com: I can't make you love me on SoundCloud - Create, record and share your sounds for free


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Buell Blast comes to a crushing end, new entry-level sportbike in the offing? [w/VIDEO]
by Jeremy Korzeniewski (RSS feed) on Jul 28th, 2009 at 8:57AM
2010 Buell Blast ottoman - Click above for high-res image gallery For whatever reason, Buell's 2010 lineup is nearly devoid of the firm's long-running Blast model. While never overtly sporty, the Buell Blast has always been considered at least a competent motorcycle. The idea had merit: A relatively inexpensive mount with a seat close to terra firma, unintimidating power delivery and easy availability from Buell and Harley-Davidson dealerships all across the country. Still, something always seemed missing from the 500cc standard – nothing, apparently, that a giant crusher couldn't... Read More


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After seven great years, it finally happend on Wednesday, May 2, 2012
It was a random Wednesday night. I left work around 5:00 pm and headed to Pauls for the evening.
When I arrived, I insisted on working out before we did anything. Paul agreed to do an Insanity workout with me. (In case you don't know, its an intense 60 Day Total Body Conditioning Program, so I couldn't miss a day.)
After a 45 minute workout, we jumped in the car and headed out to grab a bite to eat. On our drive, I reached over and grabbed Pauls hand to thank him for working out with me.
I quickly pulled my hand away and said "eeww why are your hands so clammy?"
Little did I know he had big plans for that night.
We ended up at a small hole-in-the-wall restaurant in Laconia called "Hectors". When we entered, the dining room was pretty empty but the bar area was full. I said "There are a couple seats at the bar, want to sit there and watch the game?" Paul agreed of course.
We ordered a couple appetizers and relaxed at the bar. Before I knew it, Paul was down on one knee, asking me to marry him! I said "YES!"
It was an amazing night and completely unexpected!


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Off-Label Use of Atypical Antipsychotics: An Update
Results and Summary of Benefits: Atypical Antipsychotics for Eating Disorders (Anorexia Nervosa)
Olanzapine was studied in 3 trials with a total of 84 patients, using body mass index (BMI) at 1 and 3 months as the outcome measure. No statistically significant difference between patients treated with olanzapine and those in the placebo group was detected. The strength of evidence in support of this finding is moderate. Likewise, quetiapine was studied in 1 trial of 27 patients, measuring BMI at 3 months as the outcome. No statistically significant difference between treated and control groups was detected. The strength of evidence for this finding is low. In conclusion, olanzapine and quetiapine do not increase BMI in patients with anorexia nervosa.
Keywords: antipsychotics | atypical antipsychotics | off-label | second generation | anorexia nervosa | BMI | olanzapine | quetiapine
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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Normandy Overview
The Department is doing everything in its power to keep schools open in the Normandy district. The only feasible way to do that is to establish a new district under the oversight of the State Board of Education. A fresh start allows the district to break the cycle of persistent low achievement by making deep and fundamental changes to school operations.
After listening to parents, students, staff and community members, the Department staff and Board members believe the Normandy community has been clear on their expectations and wishes, which include:
- Schools in the community
- Quality education for every child
- Support from the Department, the State and others
Therefore, the State Board created the Normandy Schools Collaborative that will operate schools in the same boundary of the current Normandy School District, effective July 1, 2014. The new entity will be governed by a Joint Executive Governing Board with members appointed by the State Board of Education.
Many of the Board's actions and the Department's recommendations came from the Normandy Transition Task Force established in March 2014 to develop a specific plan for the operation of schools in the Normandy School District should the district lapse. Some of its other recommendations include community partnerships, early childhood education and wraparound services for students and their families. The report the task force created can be viewed here: Transition Task Force Report to State Board.
Normandy Staff
All current educator contracts for the district will lapse on June 30. Many teachers will receive one year contracts for the 2014-15 school year. The Department will work closely with Normandy administrators to retain personnel moving forward while balancing the needs and expenditures of the district.
Normandy Schools Collaborative Parents
The state is working to create high quality education opportunities within the Normandy Schools Collaborative. We understand this creates uncertainty for students and families, but we will continue to communicate as information becomes available. Summer school will continue, as planned, in the Normandy Schools Collaborative.
Transfer Students
Only students who transferred in the 2013-14 school year will be eligible for transfer in 2014-15 and will be eligible only to attend the same school district they attended in 2013-14. In an effort to accommodate families, kindergarten students starting school in 2014-15 are eligible for transfer if they have a sibling who is eligible. Any student who transferred from the Normandy School District to an accredited district in the 2013-14 school year but withdrew from that same school district is no longer eligible to transfer. The ability for students to transfer is based on the new tuition rate to be paid to receiving districts. See the policy below for more information.
The district will have accreditation status as a state oversight district under a waiver from the State Board of Education. This status will remain in effect for three years, and is subject to annual State Board review and renewal. The Department will continuously review student progress. The Joint Executive Governing Board will make quarterly reports to the State Board of Education.
General Information
Anyone with questions or in need of general information about the district is asked to call 855-879-3025. Interested parties may also email questions to [email protected].
Related Documents
News Releases
- Normandy Board Holds First Meeting
- Normandy Schools Collaborative Board Members
- Normandy Finishes Year without Additional State Funds
- Work Continues on Normandy Schools Collaborative
- Statement on Francis Howell Refusal of Normandy Transfer Students
- Statement on Normandy Temporary Restraining Order Dismissal
- Normandy Schools Collaborative to Operate with New Leadership
- Normandy Transition Task Force Delivers Report for School District
- State Board Approves Emergency Action for Normandy School District
- Public Hearing Held at Normandy
- State Sets Public Hearings on Normandy School District
- State Board of Education Starts Long-Term Planning in Unaccredited Districts


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Pleurisy (cont.)
George Schiffman, MD, FCCP
Dr. Schiffman received his B.S. degree with High Honors in biology from Hobart College in 1976. He then moved to Chicago where he studied biochemistry at the University of Illinois, Chicago Circle. He attended Rush Medical College where he received his M.D. degree in 1982 and was elected to the Alpha Omega Alpha Medical Honor Society. He completed his Internal Medicine internship and residency at the University of California, Irvine.
Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
In this Article
- Pleurisy facts
- What is pleurisy?
- What causes pleurisy?
- How does the pleura work?
- What are the symptoms of pleurisy?
- How is pleurisy diagnosed?
- How is pleurisy treated?
- Can pleurisy be prevented?
- Find a local Pulmonologist in your town
How is pleurisy diagnosed?
The pain of pleurisy is very distinctive. The pain is in the chest and is usually sharp and aggravated by breathing. However, the pain can be confused with the pain of:
- inflammation around the heart (pericarditis), or
- heart attack (myocardial infarction)
To make the diagnosis of pleurisy, a doctor examines the chest in the area of pain and can often hear (with a stethoscope) the friction that is generated by the rubbing of the two inflamed layers of pleura with each breath. The noise generated by this sound is termed a pleural friction rub. (In contrast, the friction of the rubbing that is heard with pericarditis occurs synchronous with the heartbeat and does not vary with respiration.) With large amounts of pleural fluid accumulation, there can be decreased breath sounds (less audible respiratory sounds heard through a stethoscope) and the chest is dull sounding when the doctor drums on it (termed dullness upon percussion).
A chest X-ray taken in the upright position and while lying on the side is a tool in diagnosing fluid in the pleural space. It is possible to estimate the amount of fluid collection by findings on the X-ray. Occasionally, as much as 4-5 liters of fluid can accumulate inside the pleural space.
Ultrasound is a very method of detecting the presence of pleural fluid.
A CT scan can be very helpful in detecting very small amounts of fluid and trapped pockets of pleural fluid, as well as in determining the nature of the tissues surrounding the area.
Removal of pleural fluid with a needle and syringe (aspiration) is essential in diagnosing the cause of pleurisy. The fluid's color, consistency, and clarity are analyzed in the laboratory. The fluid analysis is defined as either an "exudate" (high in protein, low in sugar, high in LDH enzyme, and high white cell count; characteristic of an inflammatory process) or a "transudate" (containing normal levels of these body chemicals).
- Causes of exudative fluid include infections (such as pneumonia), cancer, tuberculosis, and collagen diseases (such as rheumatoid arthritis and lupus).
- Causes of transudative fluid are congestive heart failure and liver and kidney diseases. Pulmonary emboli can cause either transudates or exudates in the pleural space.
The fluid can also be tested for the presence of infectious organisms and cancer cells. In some cases, a small piece of pleura may be removed for microscopic study (biopsied) if there is suspicion of tuberculosis (TB) or cancer.
Next: How is pleurisy treated?
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text:
Hi all,
I'm planning a 6 foot 125 gallon tank. I'd like to have a sump... not sure how large it will be yet... thinking in the range of 30+ gallons.
I'd like to supply CO2 via a needle wheel pump, which will be situated in the sump. So the outflow of the needle wheel pump will go directly to the tank.
The pump I have in mind is the Danner model 18. I was wondering if anyone has an opinion on using this pump in the sump on this size tank.
Best regards.


text:
Februarities 1: "Trouble" with Ray Lamontagne
February 1, 2012 5:00 PM
On this date in 1898 The Travelers Insurance Company of Hartford, CT issued the first automobile insurance policy. Dr. Truman Martin of Buffalo, NY paid $11.25 for the policy, which gave him $5,000 in liability coverage.
What does this have to do with music?
[photogallerylink id=46257 align=right]Travelers Insurance had a very popular commercial that featured a cute dog and [lastfm link_type="artist_info"]Ray Lamontagne[/lastfm]'s song "Trouble" to great effect.
Tonight's rarity is [lastfm link_type="artist_info"]Ray Lamontagne[/lastfm]'s Circle of Friends performance of "Trouble".
And if you want to check it out, here's the commercial:


text:
Nurse Practitioners
Julia A. Duffy, MS, APRN, FNP-BC
Director, Student Health Center
(203) 254-4000, ext. 2241
Barbara Mulhern MS, APRN, FNP-BC
Terri Pisseri MSN, APRN, FNP-BC
Joanne Zolkowski-Wynne, M.D.
Cornell University, B.A.
SUNY-Syracuse, M.D.
Rhode Island Hospital, Brown University, Residency
Rhode Island Hospital, Brown University, Fellowship in Ambulatory Pediatrics
New England Medical Center, Tufts University, Fellowship in Adolescent Medicine
Registered Nurses
Anne Larcheveque BSN, RN
Susan Valentine, RN
Diane Widak BSN, RN
Per-Diem Registered Nurses
Joan Miller MSN, RN
Lauretta Toomey MPH, RN, NCSN, CHES
Per-Diem Nurse Practitioners
John DiGiacomo MSN, APRN, FNP-BC
Jacinta Renaldi MSN, APRN, FNP-BC
Linda Sapio-Longo MS, APRN, FNP-BC
Operations Assistant
Sheila Dunn
Staff photo (L to R): Anne Larcheveque, Diane Widak, Terri Pisseri, Susan Valentine, Barbara Mulhern, Julia Duffy, Director, Sheila Dunn, Operations Assistant, Joanna Wynne, M.D.


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Preparation, Characterization, and Application of Optical Switch Probes
Optical switches represent a new class of molecular probe with applications in high‐contrast imaging and optical manipulation of protein interactions. Small molecule, organic optical switches based on nitrospirobenzopyran (NitroBIPS) and their reactive derivatives and conjugates undergo efficient, rapid and reversible, orthogonal optically‐driven transitions between a colorless spiro (SP)‐state and a colored merocyanine (MC)‐state. The excited MC‐state also emits fluorescence, which serves as the readout of the state of the switch. Defined optical perturbations of SP and MC generate a defined waveform of MC‐fluorescence that can be isolated against unmodulated background signals by using a digital optical lock‐in detection approach or to control specific dipolar interactions on proteins. The protocols describe general procedures for the synthesis and spectroscopic characterization of NitroBIPS and specifically labeled conjugates along with methods for the manipulation of dipolar interactions on proteins and imaging of the MC‐state of NitroBIPS within living cells. Curr. Protoc. Chem. Biol. 2:153‐169 © 2010 by John Wiley & Sons, Inc.
Keywords: optical switch; nitrospiropyran; imaging
Table of Contents
- Introduction
- Strategic Planning
- Basic Protocol 1: Synthesis of 1′,3′,3′‐Trimethyl‐5′‐(N‐Succinimidyloxycarbonylpropyl)‐6‐Nitro‐Spiro(2H‐Benzopyran‐2,2′,3H‐Indole) (5′‐NHS Ester of NitroBIPS)
- Basic Protocol 2: Synthesis of 1′,3′,3′‐Trimethyl‐6‐Nitro‐8‐Iodomethylspiro(2H‐Benzopyran‐2,2′,3H‐Indole) (8‐Iodo‐NitroBIPS, 7)
- Basic Protocol 3: Absorption Characterization of NitroBIPS
- Basic Protocol 4: Fluorescence Characterization of NitroBIPS
- Basic Protocol 5: Microscopic Characterization of NitroBIPS
- Basic Protocol 6: Actin‐Labeled 8‐Iodo‐NitroBIPS
- Basic Protocol 7: Live‐Cell Imaging of NitroBIPS
- Reagents and Solutions
- Commentary
- Literature Cited
- Figures
Basic Protocol 1: Synthesis of 1′,3′,3′‐Trimethyl‐5′‐(N‐Succinimidyloxycarbonylpropyl)‐6‐Nitro‐Spiro(2H‐Benzopyran‐2,2′,3H‐Indole) (5′‐NHS Ester of NitroBIPS)
Basic Protocol 2: Synthesis of 1′,3′,3′‐Trimethyl‐6‐Nitro‐8‐Iodomethylspiro(2H‐Benzopyran‐2,2′,3H‐Indole) (8‐Iodo‐NitroBIPS, 7)
Basic Protocol 3: Absorption Characterization of NitroBIPS
Basic Protocol 4: Fluorescence Characterization of NitroBIPS
Basic Protocol 5: Microscopic Characterization of NitroBIPS
Basic Protocol 6: Actin‐Labeled 8‐Iodo‐NitroBIPS
Basic Protocol 7: Live‐Cell Imaging of NitroBIPS
Figure 1. Photochromic properties of benzospiropyran. The merocyanine (MC) state was generated by irradiation the spiropyran (SP) state with UV light (365 nm). While the excitation of the MC‐state with visible light (546 nm) generated the SP‐state.
Figure 2. Synthesis of 1′,3′,3′‐trimethyl‐5′‐( N‐succinimidyloxycarbonylpropyl)‐6‐nitro‐spiro(2 H‐benzopyran‐2,2′,3 H‐indole).
Figure 3. Synthesis of 1′,3′,3′‐trimethyl‐6‐nitro‐8‐iodomethylspiro(2 H‐benzopyran‐2,2′,3 H‐indole).
Figure 4. UV absorption spectra of NitroBIPS in the SP‐ and MC‐states in methanol during a single cycle of optical switching.
Figure 5. Fluorescence spectra of NitroBIPS in methanol in the SP‐ and MC‐states.
Figure 6. Schematic represent the inverted fluorescence microscope (Zeiss) adapted for pulse‐probe microscopy.
Figure 7. (A) Fluorescence intensity image of NitroBIPS‐labeled beads. (B) The MC‐fluorescence change corresponding to optical switch cycles of NitroBIPS in individual bead (red circle in A) over eight cycles of optical switching.
Figure 8. UV absorption spectra of NitroBIPS‐G‐actin conjugate in the SP‐ and MC‐state.
Figure 9. (A) Fluorescence intensity image of NitroBIPS in live HEK‐293 cell. (B) The MC‐fluorescence change of NitroBIPS in a region of interest (red circle in A) in live HEK‐293 cell during optical switch cycles.
Literature Cited
|Literature Cited
|Aubin, J.E. 1979. Autofluorescence of viable cultured mammalian cells. J. Histochem. Cytochem. 27:36‐43.
|Bertelson, R.C. 1999. Spiropyran. In Organic Photochromic and Thermochromic Compounds, Vol. 1: Photochromic Families (J.C. Crano and R.J. Guglielmetti, eds.) pp. 85‐109. Plenum Press, New York.
|Betzig, E., Patterson, G.H., Sougrat, R., Lindwasser, O.W., Olenych, S., Bonifacino, J.S., Davidson, M.W., Lippincott‐Schwartz, J., and Hess, H.F. 2006. Imaging intracellular fluorescent proteins at nanometer resolution. Science 15:1642‐1645.
|Chibisov, A.K. and Görner, H. 1997. Singlet versus triplet photoprocesses in indodicarbocyanine dyes and spiropyran‐derived rnerocyanines. J. Photochem. Photobiol. A 105:261‐267.
|Fischer, E. and Hirshberg, Y. 1952. Formation of coloured forms of spirans by low‐temperature irradiation. J. Chem. Soc. 74:4522.
|Flennery, J.B. Jr. 1968. The photo‐ and thermochromic transients from substituted 1′, 3′, 3′‐trimethylindolinobenzospiropyrans. J. Am. Chem. Soc. 90:5660‐5671.
|Hirshberg, Y. and Fischer, E. 1954. Photochromism and reversible multiple internal transitions in some spiropyrans at low temperatures. Part II. J. Chem. Soc. 297:3129‐3137.
|Hobley, J., Pfeifer‐Fukumura, U., Bletz, M., Asahi, T., Masuhara, H., and Fukumura, H. 2002. Ultrafast photo‐dynamics of a reversible photochromic spiropyran. J. Phys. Chem. A 106:2265‐2270.
|Inouye, M. 1994. Spiropyran derivatives as multifunctional artificial receptors for biologically important species. Mol. Cryst. Liq. Cryst. Sci. Tech. 246:169‐172.
|Mao, S., Benninger, R.K.P., Yan, Y., Petchprayoon, C., Jackson, D., Easley, C.J., Piston, D.W., and Marriott, G. 2008. Optical lock‐in detection of FRET using synthetic and genetically encoded optical switches. Biophys. J. 99:4515‐4524.
|Marriott, G., Mao, S., Sakata, T., Ran, J., Jackson, D.K., Petchprayoon, C., Gomez, T.J., Erica, W., Tulyathan, O., Aaron, H.L., Isacoff, E.Y., and Yan, Y. 2008. Optical lock‐in detection imaging microscopy for contrast‐enhanced imaging in living cells. Proc. Natl. Acad. Sci. U.S.A. 105:17789‐17794.
|Medintz, I.L., Trammell, S.A., Mattoussi, H., and Mauro, J.M. 2004. Reversible modulation of quantum dot photoluminescence using a protein‐bound photochromic fluorescence resonance energy transfer acceptor. J. Am. Chem. Soc. 126:30‐31.
|Patolsky, F., Filanovsky, B., Katz, E., and Willner, I. 1998. Photoswitchable antigen‐antibody interactions studied by impedance spectroscopy. J. Phys. Chem. B 102:10359‐10367.
|Sakata, T., Yan, Y., and Marriott, G. 2005a. Family of site‐selective molecular optical switches. J. Org. Chem. 70:2009‐2013.
|Sakata, T., Yan, Y., and Marriott, G. 2005b. Optical switching of dipolar interactions on proteins. Proc. Natl. Acad. Sci. U.S.A. 102:4759‐4764.
|Sakata, T., Jackson, D.K., Mao, S., and Marriott, G. 2008. Optically switchable chelates: Optical control and sensing of metal ions. J. Org. Chem. 73:227‐233.
|Seto, J. 1990. Photochromic dyes. In Infrared Absorbing Dyes (M. Matsuoka, ed.) pp. 71‐88. Plenum Press, New York.
|Song, X., Zhou, J., Li, Y., and Tang, Y. 1995. Correlations between solvatochromism, Lewis acid‐base equilibrium and photochromism of an indoline spiropyran. J. Photochem. Photobiol. A 92:99‐103.
|Yan, Y. and Marriott, G. 2003. Analysis of protein interactions using fluorescence technologies. Curr. Opin. Chem. Biol. 7:635‐640.


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He's known to many as the Ten Commandments judge, but now Roy Moore is back as Chief Justice of the Alabama Supreme Court.
Nearly a decade ago, Roy Moore was stripped of his Chief Justice robes, for refusing to remove a Ten Commandments monument from inside the judicial building.
"The issue was not about the Ten Commandments or rock or stone, it was about the acknowledgment about the sovereignty of God," Moore said after going under oath.
The Chief Justice said God was acknowledged throughout the investiture and oaths of office ceremony by Governor Robert Bentley and all the judges who spoke in front of the audience.
Moore wasn't the only addition to the high court, the newest Supreme Court Justice, Tommy Bryan was sworn in. Bryan has been an Alabama judge since 2005 and lawyer for 20 years.
Governor Robert Bentley oversaw the ceremonies, and said he's appreciated Moore's support, especially after beating him for the republican nomination in the 2010 governor's race.
"[Moore] said that if I had not won, he would not be here but let me say this, had it not been for this man, I would not be here," Governor Bentley said before officially commissioning Moore as Chief Justice.
Once in office, Moore he says he is focused on fixing the courts' funding.
"We've been cut in funding for so many years, that we're down far below adequate funding and we can't get cut any further," the Chief Justice said.
Moore says just as he plans to uphold the constitution, he will continue to support acknowledging God, and he wasn't alone, the Governor had the same idea.
"I truly believe that the people of Alabama are better off when we have men and women who believe there is Someone else who controls their life and this state," Bentley said.
Roy Moore will start his six-year term as Chief Justice Monday, January 14. He previously served from 2001-2003 before being removed for not upholding a federal judge's ruling on the Ten Commandments monument.


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A.P.C. The official thread for APC questions. - Page 723
Styleforum Top Picks
- Borrelli Brown SuitNo reviews yet.
- Posts: 504
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- Posts: 268
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- Posts: 118
- Joined: 6/2009
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Man I am really not digging my PS right now. I got them back in June and have been wearing them a lot. I got them hemmed to try and shorten them but they are still too long. The waist has stretched out considerably and makes the whole top block look really sh!tty. No fading has begun and not whiskering or honeycombs have started to show. I'm hoping they are going through a sort of "awkward teenage phase" and will become really nice if I just push through. I sized down to a 28, normally a 30, but they just look slouchy and have a weird fit. I even went to Gap today to look at their selvedge jeans to see if they had better fits to theirs but they don't carry the selvedge at my store. I'm really contemplating a wash to see if I can get them to shrink, but I know that would ruin them. Help! talk me out of this! Maybe I just need to hem them even more.
sounds like theyve stretched too much, you should've/can size down more..
my true waist is 32.5 and i went with a 29
Yes they shrink to original or early original size and you have to stretch them again. You can just hang dry them to make them shrink less
Thanks. Do they get a lot softer?
If I wanted a pair that is washed even from start, can I achieve a nice color (albeit without personal whiskers and shit) by just washing it like 3 times in a row? I'm asking because I recently purchased a "pioneer" jean, and it made me wonder.
No not 3 times in a row. Dude they're jeans. Wear them. Wash when they get stinky. Leave the beautiful fades up to the jeans and your lifestyle. Give them time and I promise they will come.
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if you don't wear your jeans they wont fade...they may get lighter in color but they wont fade like you see with other peoples pair. If you got the non raw pair you can go ahead and wash when ever you want. But I don't understand why you got a raw pair if you don't like stiff denim and you're trying to wash em before you wear them. If you want a natural look you gotta just wear them man and let them fade over time. If you really want go ahead and wash as often as you want. It would be nice to see a pair that has been washed tons of times compared to someone else who barely washes
NEWSTYLE - I don't see how you don't have any whiskers or combs yet. I've worn my pair maybe 30 times, probably less but I have still have nice combs and wiskers. My whiskers aren't as sharp/set in as my combs tho but you can see em.
I have two pairs of new APC. One is washed and one is raw. I don't like the raw, so I'm wondering how much and how effectively they can be made lighter (With a natural look) even before wearing them. I'm not actually declaring to do this-- I'm wondering if anyone has experience (How does the color change, do the jeans get soft immediately, etc), or if they know of an effective method of doing this. If not, I'll just return the raw jeans.
Edit: Are the back pockets on New Cure longer than the back pockets of New Standards?
Edited by yywwyy - 9/12/12 at 8:20pm


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(HealthDay News) -- If you're among the millions of people who are trying to lose weight, you may not realize that you could be at greater risk of developing gallstones.
The U.S. National Institutes of Health's Weight-control Information Network offers these suggestions to help lower your risk:
Try to lose weight at a slow pace, generally between 1/2 pound to 2 pounds per week.
Eat plenty of fiber-rich foods, such as whole wheat bread, brown rice and oats.
Avoid refined grains and reduce your sugar intake.
Choose healthy fats, including olive oil and fish oil, to help maintain healthy gallbladder function.
Aim for about five hours of exercise per week.


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Torture porn, gorn, splatter horror movies; whatever you call it, it always means the same – extreme violence, graphic torture scenes and sometimes a lot of nudity.
Torture porn is my favourite type of horror movies and I like to believe that it comes from Hellraiser where the road to pleasure is through pain! The aim is to make the deaths as realistic as possible and to make people think they're witnessing a snuff film.
Unfortunately the latest splatter films are made for young people who don't appreciate horror films as much as me and the movies are full of dumb teens who think only about partying, drinking and having sex. Then they die. Some of them have impressive deaths but overall they're pretty much crap.
To defend the gorn movies and show you that they're not made only as money machines, here I present top ten of torture horror films that you may enjoy (or not!).
10. Hostel (2005)
Director: Eli Roth
Writer:Eli Roth
Cast: Jay Hernandez, Derek Richardson, Eyhor Gudohnsson
The only reason why Hostel made the list is that some people actually like this franchise. I was not impressed by any of the Hostel movies but it's still a good watch if you're a gore n00b.
9. Meat Grinder (Cheuuat gaawn chim) (2009)
Director: Tiwa Moeithaisong
Writer: Tiwa Moeithaisong
Cast: Mai Charoenpura, Anuway Niwartwong, Wiradit Srimalai
Meat Grinder is definitely a hard watch and I hope no one will secretly follow the movie and do it in real life! Cannibal movie with a lot of creative deaths. The reason why it's not higher on the list is because some killings didn't look right. Sometimes the blood looked like thick ketchup.
8. Imprint (Masters of Horror episode 13, season 1) (2006)
Director: Takashi Miike
Writer: Mick Garris, Daisuke Tengan
Cast: Billy Drago, Shiho Harumi, Michie
This Masters of Horror episode is so fucked up I didn't know whether to laugh or cry watching it. It touches some of the disturbing social issues and provides unforgettable scenes of torture.
7. The Collector (2009)
Director: Marcus Dunstan
Writer: Patrick Melton, Marcus Dunstan
Cast: Josh Stewart, Andrea Roth and Juan Fernandez
The Collector is one of the most interesting, gripping movies of last years. You will be even happier if I tell you that the sequel is on the way!
6. I spit on Your Grave (2010)
Director: Steven R. Monroe
Writer:Meir Zarchi, Stuart Morse
Cast: Sarah Butler, Jeff Branson, Andrew Howard
I will not argue if this movie is better than the original I Spit on Your Grave (1978) but it's still a great, gory watch. Amazing what a woman can do when you disrespect her and piss her off. A must see for all revenge and torture fans.
5. Martyrs (2008)
Director: Pascal Laugier
Writer: Pascal Laugier
Cast: Morjana Alaoui, Mylene Jampanoi, Catherine Begin
If I could, I would list all the new wave French horrors in here as well. Instead I am limiting myself to Martyrs and if you don't know why it's one of the most controversial horror films then what are you waiting for? Watch it!
You can find 'Martyrs' in Top 10 French horror list
4. Guinea Pig films (Gini Piggu) (1980s)
Director: Satoru Ogura
If you have to prove that none of the actors died shooting your movie, you know you did a good job! Even though it's an old series, Guinea Pig is still considered to be one of the sickest and most gory piece of cinematography ever made.
3. Grotesque (Gurotesuku) (2009)
Director: Koji Shiraishi
Writer: Koji Shiraishi
Cast: Tsugumi Nagasawa, Hiroaki Kawatsure, Shiegeo Osako
Grotesque has been banned in many countries for being the "cruelest Japanese splatter movie ever". This alone should make you curious enough to watch it!
2. Saw franchise (2004 – 2010)
Director: James Wan
Writer: Leigh Whannell, James Wan
Cast: Cary Elwes, Leigh Whannell, Danny Glover
You like it or not, the Saw franchise rules in the torture porn sector. The first movie was so refreshing and original that it was a mother of many films that followed the blood thirst. Every movie has unique deaths with convincing special effects and I watch Saw movies only for the killings (mwahaha). The soundtrack is also worth mentioning, it's just brill!
1. A Serbian Film (Srpski Film) (2010)
Director: Srdjan Spasojevic
Writer: Aleksandar Radivojevic, Srdjan Spasojevic
Cast: Srdjan Todorovic, Sergiej Trifunovic, Jelena Gavrilovic
If you haven't heard of "torture porn" term before you would probably assume that the movie consists of porn and torture scenes (unlike Saw movies – just pure beauty of effective on-screen deaths) and it's just a disturbing invention of bored and sick psychos.
A Serbian Film is just that. The ultimate gorn that will leave your mind fucked for the rest of your life.


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Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
Sort by: Date | Rating | Most Helpful
"This turned out well, but when I reheated it, I added a little salt, one small chopped chile pepper and one cup of chick peas. Then it was really good!"
"Turned out really nice! A little on the bland side, but rose nicely and have a lovely texture. Next time I may try using buttermilk instead of water for a little more flavor."
"Really good! I will try adding a little garlic next time."
"This was good, and filling, but a little bland. It may be partly because I used fresh pumpkin and beans from scratch (not canned.) For the leftovers, I added a little more salt and a little red pepper and simmered another 20 minutes or so. That came out much more to my taste."
"This was really good, but too salty. When I make it again, I'll only use 1 tsp salt. It was also good reheated--I added some leftover lima beans and a about a cup of water and simmered it for another half an hour. That cut down on the salt, and then it was just about perfect."
"This was really great, the first time, and for leftovers! I served it over couscous. The only thing was that it was a little on the bland side. I will double the curry powder next time. Also, it makes a LOT of stew. I couldn't add the green beans because there wasn't room in the pot! It was fine without them, though. Next time I'll halve the..."
"Really good. I used a little more turkey than the recipe called for (because that's how much I had leftover from Thanksgiving) and tossed in a pinch of sage and thyme. I also cut up the vegetables pretty small. I made a homemade whole-wheat crust. The pie held together well, and makes yummy leftovers, too. This will definitely be my staple for ..."
"Really good! I added 1/4 tsp nutmeg for more flavor."
"Really good! I used fresh basil from the garden for extra punch and fresh veggies from the farmer's market. It smelled awesome cooking all day--special bonus."


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Topping Up
Digicel always gives you more! Check out this page for the different ways to top up with the bigger better network
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Digicel Online Top Up allows you to send call credit to family & friends or to your own cell phone, from anywhere in the world! It takes only a few easy steps: R...
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Inclusion Body Myositis – A Problem of Muscles
Posted on Dec 4 2012 at 11:57:58 AM in Health
Inclusion body myositis which is in short referred to as IBM is one of the diseases which involve a group of muscles. This is also known as inflammatory myopathies, and is generally typified by persistent, progressive inflammation in the muscles which are accompanied by weakness in the muscles. The inception of this type of weakness in the muscles in Inclusion body myositis is usually gradual (mostly over months or even years) and does affect both proximal (which means close to the body's trunk) and distal (which denotes further away from the body's trunk) muscles.
Muscle weakness may sometimes affect just one part of the whole body. Falling down and stumbling are typically the first evident symptoms of Inclusion body myositis. In some of the individuals, the disorder is fount to initiate with weaknesses found in the fingers and wrists that cause trouble with gripping, pinching, and buttoning objects. There may also be atrophy (referring to thinning or even loss of muscle mass) of forearm muscles and also of the muscles in the quadriceps in the legs.
Difficulty in swallowing is found in something like half of the Inclusion body myositis cases. Difficulty in swallowing is also observed in patients suffering from this syndrome. This is found to occur more frequently in men than it is found in women. The symptoms start showing up in people after the age of 50; however, the disease may occur earlier than that.
As for diagnostic tests for Inclusion body myositis, any doctor asks for a detailed medical history and the patient will thereafter be required to undergo a thorough physical examination. Blood tests are also specified which can possibly help in proper diagnosis of the disease. One of the most vital diagnostic tests for Inclusion body myositis is biopsy. For biopsy, firstly local anesthesia is applied to get a selected part of the numb. A little portion of muscle is removed mostly from the shoulder muscles or thigh muscles to test for muscle biopsy. This is the most effective way of analyzing if the disease has taken over the patient.
Corticosteroids or more commonly immunosuppressant, and anti – inflammatory drugs are common recommendations for treating Inclusion body myositis. Regularizing exercises and activities, including enough nutrition in the food intake per day, having adequate amount of rest, lessening the amount of stress from daily life and like changes in lifestyle management can also be an approach to treat Inclusion body myositis.
Know more about the problem site here provides the best information related to fibromyalgia and chronic fatigue syndrome.


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Ahead Of The Bell: US Consumer Borrowing
WASHINGTON (AP) â¿¿ Americans likely increased their borrowing in March to buy more cars and attend college, while holding off on more credit card debt.
Economists forecast that consumer borrowing rose $15 billion in March compared with February, according to a survey by FactSet. The Federal Reserve will release the report at 3 p.m. EDT Tuesday.
In February, borrowing rose by $18.1 billion to a seasonally adjusted $2.8 trillion. Nearly all of the February gains were in the category that covers student and auto loans.
Consumers have been more cautious about increasing their credit card debt. It remains 17.2 percent below the peak set in June 2008. Economists believe consumers will stay cautious about adding more high-interest debt this year. One reason is higher Social Security taxes have reduced their take-home pay.The credit report doesn't separate auto loans from student loans. But according to quarterly data compiled by the Federal Reserve Bank of New York, student loan debt has been the biggest driver of borrowing since the recession ended in June 2009. Student loans reached $966 billion in last year's fourth quarter, up $10 billion from the third quarter. During the January-March quarter, consumers increased their spending at the fastest pace in more than two years. However, they had to trim the pace of their savings to finance the faster spending. Their after-tax income dropped by the largest amount since the final three months of the recession in 2009. Part of the drop in after-tax income reflected the increase in Social Security taxes that took effect on Jan. 1. The strong consumer spending helped push overall economic growth to an annual rate of 2.5 percent in the January-March quarter. Many economists believe growth is slowing in the April-June quarter, in part because of automatic government spending cuts that began taking effect on March 1.
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The New York Yankees have officially played 52 games and post a 29-23 record respectively, which makes them now tied for first place with the Boston Red Sox, who are 30-24.
So, how has the 2011 Yankees preformed with 108 games (+two make-up games) remaining on the regular season's schedule?
The starting rotation has been surprisingly better than everyone predicted and the main reasons are solid outings by veterans Bartolo Colon and Freddy Garcia, who both have 3.26 ERAs.
CC Sabathia is the obvious ace and continues to eat innings, posting a 6-3 record, with a 2.98 ERA over 85 innings pitched. The Yankee brass would be smart to not let Sabathia hit the free agent market when he opts out at the end of the season and give him two more years on his current contract.
Also, AJ Burnett has been a different pitcher, as mentally he is in much more control than in the past. Burnett has earned the fans and his teammates trust again, as he hasn't allowed himself to collapse on the mound like we were so used to seeing every fourth or fifth start.
The bullpen has been pretty good considering they have one lefty, Boone Logan. Led by the chief Mariano Rivera, Joba Chamberlain and David Robertson have been solid.
The Yankees line-up is top to bottom stacked, but they have been weaker than anticipated even with the most home-runs in all of baseball, a whooping 80 on the season so far.
The bats also have the most RBIs with 262 and the highest slugging percentage with .447. Still, leaving runners stranded on base is becoming an all to common issue that has to improve as the team heads into the summer months.
Another issue is the lack of small ball which has killed the team, but that seems to be improving.
The players are well aware of these issues and are the first to admit that they need to fine-tune this, which is half the battle right there.
Fact is this line-up has the ability to hit better and the team should not be losing as many games because of the bats.
Catcher Russell Martin has fit in like a glove in New York.
ESPN's Amy K. Nelson recently interviewed Martin and when asked what is most important he said:
"The relationship I have with my pitchers. I want them to have to trust me with their lives."
Not only has he earned the trust of the pitchers, his bat has come up big more than a few times already this season. Martin is posting nine home-runs, six doubles, 26 RBIs, 22 walks and has stolen five bases since donning the pinstripes.
Martin's talent was never in question but whether he still had a wish to play after countless injuries was what no one knew for sure, but now we do and Yankee fans couldn't be happier.
HONORABLE MENTION: Relief Pitcher David Robertson who has dominated under pressure and come up big when the team needed some help. Robertson has a 1.27 ERA, 35 strikeouts, allowed zero home-runs, in over 21 innings of work.
Rafael Soriano, as the $13 million set-up man has only brought negative energy and now he is on the DL with an inflamed elbow for the next two months. Continue reading '2011 New York Yankees: One-Third Season Team Report Card' »


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Amisha Patel – Hot Maxim Photoshoot
Amisha Patel has always had the girl next door image specially due to her roles in her debut movie Kaho Na Pyaar Hai and her second movie Gadar: Ek Prem Katha. For all those who thought of her as 'Miss Goody Two Shoes', Amisha surprises by going outrageous in her photoshoot for the February issue of Maxim (India).
Having shed those extra kilos, the lady doesn't mind flaunting what she's got. The actress also reveals some of her hidden secrets like her ideal guy, her (by now famous) pink fixation and even gives all you men out there the much needed green signal that she is single and very much ready to mingle.
Checkout the pics and get along with your prepartions to sweep miss Amisha off her feet.
Amisha Patel – Hot & Sexy Pictures – Maxim Photoshoot
Related Articles
Fathiya: (March 5, 2008 at 11:57 am)
She doesn't get good rolls in movies, therefore,she would do anything to be noticed and for the sake of fame or money. Amisha's acting is poor, only her roll wasn't bad in her movie "Ankahee"
9 11
angel: (March 5, 2008 at 12:55 pm)
she luks soo cute..
3 6
Mariya: (March 5, 2008 at 4:58 pm)
she nt cute at all its tru wot u sed fathiya shes nt gettin much gud roles which is da reson why shes doin this… 4 money nd fame… i doubt it well help her much if thats wot she thinks… but then again all the actresses are like that they all slowly gettin down to that lane… and amisha's one of them do u agree???
6 4
Fathiya: (March 6, 2008 at 1:54 pm)
The only way for some failure actresses to be noticed is to get naked on some covershoots and look sexy, such as Amisha and Malaaika Arora.
5 5
sanko: (March 8, 2008 at 10:52 pm)
6 7
PRINCE: (March 21, 2008 at 7:13 pm)
3 2
tariq: (April 22, 2008 at 2:52 am)
I like amisha patel and I love amisha patel ager wo meri zendagi me a jay to me os ki poja karon ga
4 4
jithin: (September 7, 2008 at 5:26 pm)
i love u my ami
4 3
ajay: (September 11, 2008 at 12:14 am)
u r eyes is beautiful
4 1
Deepak Marwaha: (September 19, 2008 at 3:21 pm)
you are so cute and i don't forget you becasue i think you are the only one in the world who is like natural beauty.
Deepak (Lucky)
5 4
farhan: (September 24, 2008 at 4:54 pm)
hi guys……………..
acrdng to me she is so cute,having natural beauty,beautiful eyes and much more.
i think their is so mch to say about her bt i have no words to say about her beauty.
i wanna to meet her once in a life.
she is looking marvelous in kaho na pyar hy.
in gadar she is looking so attractive.
4 2
Santosh: (November 4, 2008 at 1:42 pm)
You r looking so beautiful & sexy
6 4
ashu: (December 18, 2008 at 11:16 pm)
Amisha looking very sexy. Her figur mind blowing
Popular 12 14
rohan: (March 18, 2009 at 12:37 pm)
hi friend , amisha is very hot becuse she is very beautyful . my dream is i become amisha waching bikini….
2 3
sharafat Ali: (May 21, 2009 at 11:24 pm)
Hi Amisha u r so beautiful & sexy I Love u. You r my dream
11 5
Shoaib: (June 9, 2009 at 5:40 pm)
H! mainsha u R very sexY I love I like U
5 5
sanju: (July 17, 2009 at 5:06 pm)
I Love You amisha
4 6
Dipak pawar: (August 14, 2009 at 3:48 pm)
you are the best beautiful girl in india and very hotest. I like you, I love you are very sexy girl in bolywood
1 10
aniket: (September 21, 2009 at 1:46 pm)
i love you my sweet heart
3 3
alexandra: (October 23, 2009 at 10:38 pm)
Hy Amisha..you are mi actrres indian preferate in Boolywood.I from Rumania en Europe…you are very beautiful and very very hot and sexy..I liked ver very much Vaada and Humko Tumse Pyaar Hai..You and Arjun Rampal make un coupke veri veri beautful..I love you Amisha Patel!!!
5 0
chandu: (October 26, 2009 at 11:47 am)
she is short otherwise ok
2 2
Cool Snake: (November 5, 2009 at 2:22 pm)
Amisha,a i love you!!!! you have the biggest assets in the bollywood girls, you are so soft and sensual that i cant stop myself from dreming about you,
3 3
nilab: (November 27, 2009 at 4:13 am)
who says that Amisha is not beautiful
she is my life i love her a lot
2 3
patrick aneel: (January 1, 2010 at 10:25 pm)
hi u r so sweet
6 1
Niloy: (January 19, 2010 at 11:21 am)
4 5


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Book your room at Rosen Inn International
Family-friendly hotel with an outdoor pool, in Orlando (International Drive)
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
This family-friendly hotel is located in Orlando (International Drive), close to Titanic the Experience, Phillips Crossing, and Pirate's Dinner Adventure. Also nearby are Sleuth's Mystery Dinner Show and Ripley's Believe It or Not.
Hotel Features
In addition to a restaurant, Rosen Inn International features an outdoor pool. Other amenities include a bar/lounge and complimentary wireless Internet access.
Room Amenities
Televisions come with premium cable channels. Guestrooms also feature complimentary wireless Internet access, refrigerators, and microwaves.Information missing or incorrect? Tell us!
At your hotel
At your hotel
Rosen Inn International features an outdoor pool and a fitness center. The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. High-speed wireless Internet access is complimentary.
Business-related amenities at this 3-star property consist of a business center and limo/town car service. 2 meeting rooms are available. This family-friendly hotel also offers tour/ticket assistance, an arcade/game room, and multilingual staff. For a surcharge, the property provides a roundtrip airport shuttle (available on request) and an area shuttle. A total renovation of this property was completed in January 2012.
Rosen Inn International is a smoke-free property.
- Airport transportation (surcharge)
- Arcade/game room
- Total number of rooms - 728
- Number of floors - 6
- Bar/lounge
- Elevator/lift
- Fitness facilities
- Free Wi-Fi
- Wired (high-speed) Internet access - surcharge
- Grocery/convenience store
- Tours/ticket assistance
- Garden
- Gift shops or newsstand
- Shopping on site
- Luggage storage
- Area shuttle (surcharge)
- 24-hour front desk
- Business center
- Limo or Town Car service available
- Multilingual staff
- Number of meeting rooms - 2
- Smoke-free property
- Dry cleaning/laundry service
- Theme park shuttle (complimentary)
- Laundry facilities
- Restaurant
- Outdoor pool
Stay connected
Available in all rooms: Free Wi-Fi
Available in some public areas: Free Wi-Fi , Wired (high-speed) Internet access - surcharge
In your room
- Pay movies
- Phone
- Premium TV channels
- Cribs/infant beds available
- Microwave
- Refrigerator
- Coffee/tea maker
- Free Wi-Fi
- Air conditioning
- Hair dryer
- Iron/ironing board
- Desk
- In-room safe (laptop compatible)
- Cable TV service
Eat and drink
Fountain View Cafe - This restaurant serves breakfast and dinner.
Recreational amenities at the hotel include an outdoor pool and a fitness center.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- Accessible parking
- Roll-in shower
- In-room accessibility
The fine print for Rosen Inn International
When you arrive
Check-in time starts at 4 PM
When you leave
Check-out time is 11 AM
How you can pay
Your pets
Pets allowed, Maximum number of pets per room 2, Pet maximum weight in lb is 50
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Breakfast fee: USD 7.95 per person (approximately)
- Pet fee: USD 15 per night
- Pet deposit: USD 50 per stay
- Rollaway bed fee: USD 15 per night
We should mention
This property offers transfers from the airport (surcharges may apply). Guests must contact the property with arrival details before travel, using the contact information on the booking confirmation. Children 17 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.
Kids Eat Free
Book a stay in any room or rate category and 1 child age 9 and younger eats free when accompanied by a paying adult.
Details at check-in. Restrictions may apply.


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Orient-Express Hotels Ltd. Second Quarter 2012 News Release And Conference Call
HAMILTON, Bermuda, July 3, 2012 /PRNewswire/ --
Orient-Express Hotels Ltd. (NYSE: OEH, http://www.orient-express.com) will release its second quarter earnings on Wednesday, August 1, 2012 after the market closes and will host a conference call for the investment community on Thursday, August 2, 2012 at 10am EDT ( 3pm BST). Conference ID: 9423387 .
Anyone wishing to join in the call should dial + 1- 877 2 49 9037 (US toll free) or +44(0)20- 3140 8286 (Standard International access). (Phone lines will open 20 minutes prior to the call).
Please note that the call is open to investors only. Media enquiries should be addressed to Vicky Legg at the contact details above.NOTE: A replay of the conference call will be available by telephone until 7pm (EDT) Thursday, August 9, 2012 and can be accessed by calling +1-866-932-5017 (US toll free) or +44 (0)20 7111 1244 (Standard International). The access code is: 9423387#. A replay will also be available on the company's website at: http://www.orient-expressinvestorinfo.com/ Contact - Investors: Martin O'Grady Vice President, Chief Financial Officer Tel: +44-20-3117-1333 E: firstname.lastname@example.com Amy Brandt Director, Investor Relations Tel: +44-20-3117-1323 E: email@example.com Media: Vicky Legg Director, Corporate Communications Tel: +44-20-3117-1380 E: email@example.com SOURCE Orient Express Hotels Ltd
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Brock Huard: Not enough tax money to entice NBA, David Sternon May 16, 2013 @ 8:26 am (Updated: 12:53 pm - 5/16/13 )
Sonics fans hoped that even if the Kings stayed in Sacramento, expansion could be on the table, but Stern said it wasn't.
710 ESPN Seattle's Brock Huard thinks the issue is still about ego: "Don't get this wrong. Seattle, the mayor, the political people, you didn't bow to [David Stern.] You didn't cower to the NBA like many of these other municipalities do."
Huard thinks because Seattle didn't throw a lot of tax money at the NBA, and instead looked to get a majority of the funding privately, the NBA didn't like the proposal.
While other cities, like Sacramento, are using tax money to entice David Stern and the NBA or keep them content, it could really hurt them in the long run. Huard has read the plan that raises money from their parking revenue and garages. He's concerned about what it will do to the city if it spends $250-$350 million that they don't have from parking meters.
Meanwhile, Chris Hansen is laying his chips on the table. Huard is positive with Hansen still intent on purchasing 20 percent of the Kings, it's leverage to find the middle ground with the NBA. That median, Huard said, will be expansion.
Alyssa Kleven is an editor and content producer at MyNorthwest.com. She enjoys doting over her adorable dachshund Winnie - named for Arcade Fire front-man Win Butler.
Return to Dominance
The Seahawks beat Arizona 35-6 to move into tie for NFC West lead
Week in Photos
Cheetahs, penguins and Santa make it in this week's photos
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Space Weapons Concepts Before Their Time: Timeline
Does China have military aspiration on the moon? Its not likely. Science fiction (and Popular Mechanics editors from decades past) have predicted that warfare would make the jump to outer space since the Fifties. Fortunately, this isnt the case today. Here are some of the top ideas on space weapons, from past issues of Popular Mechanics.
By Sam Roudman
Star Wars Concept
An illustration found in the February 1984 issue gives an artist's concept of the U.S.'s Strategic Defense Initiativebetter know as the "Star Wars" program.


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004 ace x porter passport
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Ace Hotel and Japanese malletiers Porter by Yoshida team up to create a beautiful passport wallet for all your identification and travel documents. Made of durable canvas and lined with soft leather, it features a chunky zipper and leather zip pull with pockets for your passport, notes and licenses. It also has an external pocket for your boarding pass. Perfect for you next trip.
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Sighting: Emmy Rossum dines at Sunda
The first place Emmy Rossum had dinner while in Chicago this week to film exterior scenes for the upcoming season Showtime's "Shameless" was Sunda. Rossum dined at Sunda on Sunday and then plugged the Asian restaurant on Twitter, as she is known to do for restaurants she visits.
Luis Gomez
November 13, 2013


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What Did You Think of "The Treasure of Serena Madre"?by Steve Marsi at . Comments
The 11th episode of Season 3 just aired, featuring more Thanksgiving drama on the UES than even we saw coming - and it's our job to see it coming!
Did you love tonight's Gossip Girl? Did it live up to the hype? Was it disappointing? Confusing? Did you find "The Treasure of Serena Madre" boring?
We want to hear what you think!
Share your thoughts on all of this evening's Gossip Girl by leaving comments and voting in our poll below. Tell us if you liked the episode and why!
Oh, that Chuck Bass look.
"The Treasure of Serena Madre" was ...
Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.Tags: Gossip Girl
Serena is and will always be a slut! Nothing new..she can't even hide it anymore, everyone knows and she'll never change. The apple doesn't fall too far from the tree.
How it's named The song at the thanks giving dinner? can anyone tell me? is it Hide and Seek from Imogen, or it's another one?
wow, somebody said Chuck staying with Nate instead of flying to Paris with Blair indicate missing passion in their r'ship. Chuck has grown a lot this season and him staying with Nate is a sensible decision and does not in ANY way indicate Chair lack or absence of passion. But i do agree with ppl saying that Chair is getting boring, not because of the lack of chemistry but they just don't have a story YET, with Serena sneaking around with a married congressman, who can top that? Remember, this season is ALL about SERENA, oh, it's also a season to make Vanessa MATTER, to PUSH Jenny as a stronger main character and REDEFINE Dan. So yeah, CHAIR hotness will have to wait. They have lots of character to put forward this time around. Quit bitching alright?
TFV168 Says:
December 1st, 2009 10:22 AM Nothing says 'Thanksgiving with family, friends, the guy you're having an affair with and his wife' like a catsuit! Seriously?! WORD!
Even though I love the name Stripp - god Serena is a hobag! How could you turn down Man Bangs?? Two of the dumbest beautiful people in the history of TV get together, but they're too dumb to get together (well Serena is too dumb, Nate actually ended up outsmarted her - to be honest... it's not hard). CHAIR - show some more hot Chair scenes, good Chuck is starting to get a little boring...
i don't know why so many people like this epi. all the scenes are rushed through . every 5 seconds i see a different scene I get headache.. i know there are drama brewing, but writers, pls give more time to develop them. and you're trying to squeeze tooooo much into one epi. the writers also have turned Chair into the biggest anti-climate. what a waste after all the built up in S1 & S2. it's unreal that they now act like married couples of 20 years.
I totally agreed with syrelia and mary .. very good points At first, Serena pissed me off but then i realized that it's good that she made horrible decision .. she seem to messed up this season, everything she touched turn out to be bad so she need a lesson to bring her down to the ground again .. and i don't think that they will last if serena decide to go with nate .. They need drama to help their feeling stronger just like Blair and Chuck (at least that's what i think) and I know that what serena did to nate is awful .. a lot of people think that now serena is not deserve nate .. i know that nate said such a sweetest thing to serena but i just wondering why now ?!? Is that because of Nate is lonely?!? they were on a fight and not spoken to each other before his feeling start again .. people said that serena is always jump from guy to guy .. didn't nate do the same?!? .. i think he did .. and now just that serena is having a guy maybe that's why she didn't jump to nate?!? at least she never cheat on her partner but nate did and nate did have affair to married women too so, can we call it even?!?
I loved the touch of "Watcha Say" during the Thanksgiving dinner. Best Gossip Girl song placement, especially with all that drama!


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Reviewed By Larry H (Saint Paul, MN) Reviewed for a 2003 Ford F-150 —9/4/2014 9:43 AM
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Reviewed By David S (COLUMBIA, SC) Reviewed for a 2003 Ford F-150 —7/6/2013 6:48 AM
I ordered this for my 2003 ford f150 FX4. The installation n was a breeze. Just measured where I was going to put it, peeled off the back of the two way tape and stuck it in place. Plugged in to the four way plug on the truck and done. Wow that it. Put the tailgate back on and that's it. Great looking, works grea . Would recommend this product. Very satisfied. Thanks Auto anything
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This unique 15th-century former ducal residence in Bruges is only 305 yards from the Markt. There are 2 people looking at this hotel. More
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Paige Edgemont striped low-rise skinny jeans
- Black and white striped stretch-denim
- Belt loops, five pockets, zipped pockets
- Button and concealed zip fastening at front
- 98% cotton, 2% elastane
- Machine wash inside out to avoid color transfer
Sold Out
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Ripped holes give these slouchy-skinny Paige Denim jeans a worn, grunge-inspired look. Faded wash with hazy whiskering. 5-pocket styling. Button closure and zip fly. Fabric: Denim. 100% cotton. Wash cold. Made in the USA. MEASUREMENTS Rise: 8in / 20cm Inseam: 30in / 76cm Leg opening: 12in / 30.5cm
Paige Denim Jimmy Jimmy Skinny Jeans $229 $68.70
These skinny ankle jeans take on a sleek, leather-like look with a cool coated finish.;Belt loops and button at self waist;Zip front;Four-pocket style;Rise, about 8";Inseam, about 28";Lyocell/cotton/rayon/polyester/spandex;Dry clean;Imported;Model shown is 5'10" (177cm) wearing US size 4.
A mid rise super stretch ultra skinny that hugs the leg down to the leg opening. Features shredding at one knee and finished in a metallic black crinkled foil that's coated to perfection. Undeniably eye-catching and perfect for nighttime. To achieve this unique look, Italian foil is hand-coated onto black denim, then distressed by hand for a textured effect. This jean offers high stretch and holds you in without sacrificing comfort. It moves with you all day and won't bag out. Front Rise: 8 1/8" Inseam: 30" Leg Opening: 10 1/4" 9.7 oz Fabric 98% Cotton, 2% Elastane
54% rayon, 23% cotton, 22% polyester, 1% spandex. Machine wash cold. Imported. Paige Verdugo Ultra Skinny Jean Tristan wash Verdugo Ultra Skinny Jean Five pocket styling Zipper fly with button closure Slight whiskering and fading throughout Skinny silhouette Belt loops Made in the USA Model is 5'9", wearing a size 26 8 1/8" rise 30" inseam 10 1/4" leg opening True to size
Paige Verdugo Ultra Skinny Jean $179 $139.99
These Paige Denim skinny jeans have oxidized zip accents for a hit of edge. A hint of fading accents the dark grey wash. 5-pocket styling. Button closure and zip fly. Fabric: Lightweight stretch denim. 92% cotton/6% elastomultiester polyester/2% elastane. Wash cold. Made in the USA. Measurements Rise: 8.5in / 21.5cm Inseam: 27in / 68.5cm Leg opening: 10in / 25.5cm Measurements from size 27
Paige Denim Jane Zip Ultra Skinny Jeans $239 $167.30
With zip front pockets and a glossy, leather-like coating, skinny jeans mix tough-girl style with a glamorous sheen. Faux front pockets keep a smooth silhouette, and patch pockets detail the back. Button closure and zip fly. Fabric: Coated stretch denim. 42% lyocell/33% cotton/15% rayon/9% polyester/1% elastane. Dry clean. Made in the USA. MEASUREMENTS Rise: 8in / 20cm Inseam: 30in / 76cm Leg opening: 10in / 25.5cm
An edgy coated finish lends sleek second-skin appeal to a pair of ultra-stretchy low-rise skinnies. 28" inseam; 10" leg opening; 8 1/2" front rise; 12 1/2" back rise (size 28). Zip fly with button closure. Faux front pockets. Lyocell/cotton/rayon/polyester/spandex; dry clean. By Paige Denim; made in the USA. t.b.d.
Front zipper details offer edgy appeal to hand-coated, leather-like skinny jeans in a deep black hue. 30" inseam; 10 1/4" leg opening; 8" front rise. Zip fly with button closure. Four-pocket style. 42% lyocell, 33% cotton, 15% rayon, 9% polyester, 1% elastane. Dry clean. By Paige Denim; made in the USA. t.b.d.
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I thought I'd start the title discussion thread for: 12/6 "Amazing Grace, How Sweet The Sound".Ever since I started watching the show, I knew this was going to be the title of an episode someday!I don't know who will say the title, but I will guess at whichever team wins the race says the title, as they run to the mat.
I vote for Elvis