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ClinicalKey replaces MD Consult. It delivers all of Elsevier's medical and surgical content in one resource and is not limited by number of users. It provides physicians access to over 900 books, 500 journals, thousands of videos and millions of images. (Source: Producer Web Site)
Dates Covered: Not listed.
Update Frequency: Not listed.
Producer: Elsevier, Inc.
Provider: Elsevier, Inc.
Format: Web site
Access: Available from off campus to current ETSU students, faculty, and staff.

subset: commoncrawl


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Blag Hag has moved!
Monday, February 15, 2010
I literally screamed with nerdy glee
Seriously, this is freaking amazing. I just had biggest nerdgasm since I found out Dumbledore was gay or that Alan Rickman was doing the Voice for Marvin, the Paranoid Android. This is a thousand times better than my Darwin/Pokemon mash up. I'm just sad I didn't think of it first.
There goes eighteen more dollars from my wallet.
13 comments:
What a geek you are. ;-)ReplyDelete
OMG! I just nerdgasmed, too!ReplyDelete
This is possibly the best shirt ever.ReplyDelete
The real question is what six Pokemons does Darwin carry around with him at all times?ReplyDelete
- WarofartFebruary 15, 2010 at 2:19 PM
Ok, that is actually deseverving of the much overused word epic.ReplyDelete
I do believe I need this shirt. Badly. o.0ReplyDelete
Ahahahaha... Seriously, Pokemon was made for a Mashup with Darwin...ReplyDelete
I've made this for Darwin's B-Day 8D
Damn you, making me wish I had money. ;_;ReplyDelete
The real question is what six Pokemons does Darwin carry around with him at all times?ReplyDelete
I don't think he would have had Mewtwo - or would he?
- Svlad CjelliFebruary 16, 2010 at 1:43 AM
Err - a Blastoise shell the same size as a Charizard skull? o_OReplyDelete
I, too, loved that Alan Rickman was Marvin...AND I need this shirt. I've banned myself from Threadless due to excessive spending, but I may need to temporarily lift the ban... :-PReplyDelete
Svlad Cjelli said:ReplyDelete
Err - a Blastoise shell the same size as a Charizard skull? o_O
Maybe it's a model. Blastoise is huge; it would be difficult to have an actual shell around for reference...
- AnonymousFebruary 21, 2010 at 9:11 AM
On the other side... http://www.2pstart.com/2010/02/18/the-first-pokemon-trainer/ReplyDelete


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Separate names with a comma.
Discussion in 'Nuttin' but Net' started by InstiGATOR1, Jul 2, 2013.
Here is his top seeds:
and here is the link to the article and entire field:
NO Kentucky?
Hey...I'll take it!!!
They were listed as a 2 seed. He mentioned in the article that he gave Florida a slight edge over UK for the 1 seed based on experience.
I think UK gets a 1 seed, but I guess I wouldn't be blown away if it was a 2.
What I don't get are people like this writer who just can't picture anything happening for the first time. First it was no team could win a title depending heavily on freshmen. Well, until it happened I guess. Now it has shifted. Now its "Well you CAN win with freshmen, but you NEED returning talent that contributed heavily on a past team..." Well, that IS how it worked for UK's 2012 team. Does that mean its absolutely required? I don't think so.
This doesn't mean UK will, undoubtedly, be dominant next year. But I don't agree with the guys logic. It doesn't stand up.
Unfortunately, I think he underrates Louisville as well.
I agree with this article. I think Florida wins the SEC (again) and takes the #1 seed.
However, it is possible that the SEC could get two #1 seeds but only if both teams have 3-4 losses or less.
One other thing, only three sec teams make the NCAAs? I would think LSU (having a strong front-court) can make it along with a few others (i.e, Missouri, Ole Miss, Alabama?, ?Vandy, Arkansas, etc.).
Interesting points from the article,
For the SEC to get two #1 seeds, I think that both Florida & Kentucky will have to do very well in non-conference play. To do so, UF will have to defeat all of the high profile teams on their slate (i.e, Kansas/Wiggins, UConn, Wisconsin, Memphis & FSU) and so will Kentucky need to do so (i.e, Michigan St, Louisville, North Carolina, Baylor, etc.). With Wilbekin's suspension, it could be more difficult for the Gators if Hill struggles at point guard. Similarly for the wildcats, it will be difficult for an all-freshman squad to defeat top veteran teams like the Spartans in November and Cardinals in December.
UK non-conference schedule
Obviously, now is a far better time to do such crazy projections than before NBA draft depletion has had it's effect.
Nonetheless, we really haven't much of a clue as to how well any team will play next year.
Heck, even 4 weeks into next year's conference schedules is far too early to make "quality" projections.


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My name's Ella and I'm the Alpha Pet around here (that's me on our page headers).
When my Human Friend (HF) suggested that we set up an online shop so that other pet partnerships could also benefit from all the beautiful accessories that have been bought for me, I wasn't sure that I liked the idea. I mean, why would I want other dogs walking around wearing the same bling as I do. (O.K. I don't always bling myself up, but you get my drift.)
My HF pointed out that there are lots of supermarkets and pet supermarkets that most people buy their pet accessories from so it would be a very select group who would buy our chosen merchandise.
That made sense to me, so I've been helping my HF to trawl the cyber-marketplace for some stylish accessories so you don't have to.
We're constantly updating and expanding our range, depending on my mood, time of year, special occasion etc etc. So we'll always have lovely things that you (probably) won't be able to find in the supermarkets. But we know there will be things we haven't included in our range that you may be looking for. So please let us know if there's something you'd like us to stock – or if you have any suggestions or comments we'd love to hear from you. We'd especially like to see your furry friends dressed in their finest AlphapetOnline accessories – so send us your pictures and we'll build a photo gallery for you. You may even be featured on our front page.
Oh, BTW, there are two other pets in this organisation who, I hate to admit, are pretty cool for cats. They choose their own accessories. It has nothing to do with me (see below).
Lovingly paws
EllaPS: I'm wearing my Princelet red velvet collar in the photo. Pawjus!
Hello. My name's Max and I just keep my head down.
I may be twice the size of Archie, but he's no push-over I can tell you. I've tried. Anyway, I'm a lover - not a fighter.
I'm in touch with my feminine side. I love all the bling, cos I know it really suits my colouring and brings out the glow in my eyes. Big Ella (as I call her) seems to have a lot more stuff than we do, but she does a lot more visiting and parading up and down the high street so she 'has to look her best at all times' (her words, not mine).
Still, I know that our HF has someone in America who is on the look out for some good stuff for us. So come back and visit us often and see what's been added. And send in your pussy cat pics too. Can't let the dogs have all the glory can we? BTW, I'm wearing a Felix cat collar, which looks pretty cool don't ya think? Only problem is the bell does have a habit of alerting any mice in the area that I'm on their tail. Still, I guess it's a small price to pay for star quality.
Felinely yours
Yeowww! I'm Archie Smart. New kit on the block. I love to play, jump on Max's back, and give big Ella the run around. I guess I'll have more to say when I'm a bit more grown up. At the moment my job at AlphapetOnline is to have fun and look cute on the website banner. Yowzahs!
High fives my friends x
Hi. I guess I must be the Human Friend - aka HF to Ella, Max and Archie.
I am also responsible for making sense of all their ramblings and translating them for the web site into something you can understand.
The gang tell me what they think of the products, how it feels, how it looks (through their eyes), what they like, what they don't like. If it's good quality, value for money and stylish it gets a big paws up from the team, which is where my work begins; sourcing, buying, adding to the web site and letting everyone else know about it.
So we hope you enjoy browsing our web pages, and we hope you'll enjoy shopping with us too.
Please sign up for our newletter and be the first to know about special offers and special products that will be coming this-a-way very soon.
Your faithful servant,


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New pieces of luggage are an investment that had best last for a long span. Shopping for high caliber baggage is the foremost method to secure this. It is far better to pay out the funds on a high quality luggage set that will endure many years than to purchase a cut-rate one and have it fall apart after the initial or next trip. It may appear as if you are saving dough if you purchase low-priced suitcases, but you end up paying a lot more in the long run. Suitcases take excessive amounts of ill-treatment when you go touring. After they have been checked in at the airport, they are frequently tossed around and have other suitcases lying on top of them. This manner of abuse will quickly show the worth of the bag you have bought. Bargain pieces of luggage will fall apart or will begin to have tears or destroyed zippers and so forth after just a few trips. The more costly, higher quality bags are much more likely to handle this type of overuse smoothly, and will last you a myriad of years.
To ordain whether or not a bag is of high quality, there are a smattering of things you should look for. The way the suitcase has been constructed is highly paramount. The things you need to examine are the seams, the strength of the fabric weave, what the frame is manufactured of, whether or not the handles stick out and if it comes with portable or adjustable straps, what form of wheels are on the luggage, the size of the zippers, the size of the compartments, and how chunky the piece of luggage itself is.
Besides, depending on how usually you go on vacation and how far, you need to probe the heftiness of the suitcase. Airlines are somewhat uptight on their weight restrictions, and everything over will cost you additional money. If you are an extensive international explorer, or are absent from home for extended periods of time, you will need to pack tons of things. Non-heavy suitcases are the excellent choice for these types of travelers. They will allow for more things to be packed before the weight limit is reached. However, if for those worried about their belongings or are transporting breakable objects should consider purchasing a hard-sided suitcase. These suitcases are generally heavier than their fabric or leather counterparts, but they add an extra piece of mind that the luggage and all belongings will arrive safe and sound.
No matter which option you prefer, make sure to inspect your new suitcase amply before you purchase it. Even if you want to acquire a bargain one, it can still save you time and coin. Appraising it closely will allow you to catch problems before they cause you problems and will help you get the perfect value for your dough. Keep in mind that a piece of luggage is a big and valuable expenditure and not one that need to be pressed.
When looking for information on Suitcase sets, please visit us.


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Designed specifically with small-business needs in mind, these digital, corded office phones offer cost-control features such as toll restriction, an intercom and a message waiting light for improved user productivity, and after-hours attendant controls with a Night Mode. There is also plenty of room for growth: These phones can handle up to six lines and are Computer Telephone Integration (CTI) ready for hassle-free linking to your computer system when used with Vodavi's Discovery CT.
Like this article? Get this issue right now on iPad, Nook or Kindle Fire.
This article was originally published in the April 1998 print edition of Entrepreneur with the headline: Good Calls.


text:
Fall's 50 Best Shoes and Boots for Under $200
An affordable guide to this season's new footwear.
Skip to content, or skip to search.
Skip to content, or skip to search.
They're the perfect complement to cropped pants and full skirts.
From stacked heel boots and geometric pumps, to pointy flats and patterned brogues: see them in all their enlarged glory.


text:
Vertex Advances One of Two Hep C Drugs
CAMBRIDGE, Mass. ( TheStreet) -- Vertex Pharmaceuticals (VRTX) is advancing one experimental hepatitis C drug into mid-stage clinical trials while shutting down work on a second drug due to poor efficacy, the company announced Tuesday.
Both Vertex drugs, ALS-2200 and ALS-2158 belong to the class of hepatitis C drugs known as nucleotide (or nucleoside) polymerase inhibitors -- commonly referred to as "nucs" -- which have the potential to become the backbone of new, all-oral combination regimens.
The current superstar of the "nuc" drug class is Gilead Sciences' (GILD) GS-7977, but Bristol-Myers Squibb (BMY) was forced to abandon its nuc BMS-094 because it caused heart failure. The fallout from Bristol's drug has since spread to Idenix Pharmaceuticals (IDIX) and its nuc IDX-184, which is on clinical hold until U.S. regulators are assured the drug is safe.
The combination of ALS-2200 plus ribavirin yielded a 4.2 log10 reduction in viral load after seven days of dosing in previously untreated, genotype 1 hepatitis C patients. Eight patients were treated, of which five were able to achieve undetectable levels of the hepatitis C virus, Vertex announced Tuesday.Vertex also disclosed that the "uridine" chemical structure of ALS-2200 is the same as Gilead's GS-7977. This is important since the recent safety issues related to nucs appear to be limited to those drugs with a "purine" chemical structure. Based on these results, Vertex plans to move ALS-2200 into two, phase II studies. One study will evaluate ALS-2200 in combination with ribavirin, the other study will combine ALS-2200 with Vertex's currently marketed hepatitis C drug Incivek. Vertex is discussing the new studies with regulatory agencies and hopes to begin enrollment before the end of the year. While Vertex is making progress towards developing an all-oral regimen for hepatitis C, the work being done by Gilead and others is still considerably in the lead. Vertex's ALS-2200 may also be less potent than GS-7977. Vertex's ALS-2158 will not be moving ahead into new studies due to insufficient antiviral activity, the company said. Vertex shares were down 1.5% to $57.86 in early Tuesday trading. --Written by Adam Feuerstein in Boston.
>To contact the writer of this article, click here: Adam Feuerstein. >To follow the writer on Twitter, go to http://twitter.com/adamfeuerstein.
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text: Excursion Inlet Unincorporated in the Haines Borough Community Details Area Type Place of Interest Current Population 8 Population Comment 2013 Department of Labor Estimate Pronunciation/Other Names Census Designated Place (CDP) Yes Borough/Census Area FIPS Code 100 Place FIPS 23900 Economy Subsistence Yes Local Labor Market Info URL http://live.laborstats.alaska.gov/alari/index.cfm?r=5&b=9&p=94&goplace=go Economy - Fisheries Participation, and Earnings CDQ Participant No CQE Eligible No Count of Seafood Processors 1 All Fisheries, Permit Holders 0 All Fisheries, Permits Issued 0 Election, Recording, and Judicial Districts Senate District Q House District 33 Judicial District 1 Recording District Juneau Facilities and Amenities Broadband Internet Available Yes Broadband Cell Phone Services Yes Cell Phone Service Available Yes Max Upload Speed Available 3 Mbps to 6 Mbps Max Download Speed Available 10 Mbps to 25 Mbps Geography and Climate Location Excursion Inlet is located in the Haines Borough, on the west coast of Lynn Canal, 38 miles northwest of Juneau. Community Map Available No Latitude 58.4214 Longitude -135.4367 Sq Mi Land 0.00 Sq Mi Water 0.00 Climate The area has a maritime climate characterized by cool summers and mild winters. Average summer temperatures range from 46 to 76 °F; winter temperatures range from 13 to 36 °F. History and Culture History The community was first settled as a cannery at the mouth of Excursion Inlet. The name was first reported in the 1943 USC&GS Coast Pilot. During World War II, Excursion Inlet became a resupply point for the Aleutian campaign. Culture A number of the residents are retired. Federally Recognized Tribe No Housing - 2010 Census Total Housing Units 71 Total Occupied Housing Units 6 Occupied Housing Units (%) 8.5 Owner Occupied Units (%) 66.7 Renter Occupied Units (%) 33.3 Total Vacant Housing Units 65 Vacant Housing Units (%) 91.5 Vacant Due to Seasonal Use (%) 92.3 Municipal Powers Transportation Transportation The area is not accessible by road. A public seaplane base is available. Harbor/Dock No State Ferry No Cargo Barge No Road Connection No Coastal Yes


text:
Richard Wellington Swift, MD
Ratings based on 4 reviews
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Thank you traveller, for finding your way to Qubenzis's own music store. Here you can buy high resolution audio files, loops and samples directly from the artist(s). Choose from a multitude of tracks and several sample packs optimized for professional electronic music production.
Music player :: Can be used to hear many of the newer tracks created by Qubenzis Psy Audio. Additionally there are smaller players found on the individual song and sample pack product pages.
All Samples and Loops are delivered in lossless audio 16Bit / 44.1Khz / WAV! Songs and tracks are mostly in FLAC and mp3 320kbps audio format. The FLAC audio files can easily be expanded into WAV again. You can read more about that on the About page, which also contains some background on what's going on here in Qubenzis Download Store.


text:
This 2-day course provides the information needed to convert applications to run on the Integrity NonStop systems and the Integrity NonStop BladeSystem. The course starts with an overview of the hardware architectures and then covers program migration information for each of the main languages. Other topics include the debuggers that are available on the new systems including the new Native Inspect debugger, the new linker, the changes to the ETK, the EPE, and the new Code Coverage and Code Profiling tools. Hands-on labs are used at various points to provide reinforcement of the lecture.
At the conclusion of this course you should be able to:
Module 1 - TNS/E Architecture Overview
Module 2 - Compilers
Module 3 - Linking and Accelerating Applications
Module 4 - Debuggers
Module 5 - Workstation Tools
Module 6 - Code Profiling Utilities
Module 7 - Application Migration
Appendix - J06.12
Onsite Delivery Equipment Requirements


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Lisa Rosenthal has over twenty-five years of experience in the fertility field, including her current roles as Coordinator of Professional and Patient Communications for RMACT and teacher and founder of Fertile Yoga, a class designed to support, comfort and enhance men and women's sense of self. Her experience also includes working with RESOLVE: The National Infertility Association and The American Fertility Association, where she was Educational Coordinator, Conference Director and Assistant Executive Director
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The Holiday season is here. Maybe you believe that it doesn't begin until Thanksgiving. For me, Halloween ushers in the roller coaster of up's and down's that don't end until after the beginning of January. The almost endless gatherings and celebrations for family and friends.
A time where it feels impossible to get away from the questions, comments and uncomfortable silences. The questions are eerily similar, regardless of your ethnic background or religion. The questions conform easily to those asked of an investigative reporter. Who, what, where, why and when.
Who is having them. (Not us right now!)
What are we waiting for? (Ummm…. For it to happen???)
Where do we fit as a family, marriage, partnership without them? (Perhaps the loneliest question to wonder about.)
Why aren't we pregnant yet? (Made me burst into tears on more than one occasion.)
When are we going to give our parents the grandchildren they are hoping and wanting? No one's getting any younger! (In case infertility is not challenging enough, let's throw a little guilt at it!)
How sad is it that those are only a single variation on a theme that most of us are very familiar with. It's very possible to create scores of different questions based on the 5 W's above; all pierce the heart of those of us trying to build our families.
Holidays are also a great time to gain weight. For a few of us, that's a plus. For many of us, not so much. Dr. Cynthia Murdock and Carolyn Gundell, MS, (both from RMACT) will be speaking at the seminar this weekend, open to the public. Information on how to attend is below.
What I can share about this seminar is that last year I made sure to attend as I was tired of the eat too much, gain weight, feel guilty, have to lose weight holiday season. Carolyn spoke eloquently and compassionately about the issues around hunger, food, weight and the holidays; she gave realistic, helpful and new outlooks on how to cope with all reasons that I had for gaining weight. What I know is that I gained no weight during the holidays last year. In fact, I lost two pounds.
I'll be there this year. Hope to see you there as well.
Fall 2010 Fertility Seminar Series
Seminars held at our Norwalk office: 10 Glover Avenue, Norwalk, CT
Please check our website or call to confirm date, time and/or location as they are subject to change
Saturday November 13th 11:00 AM -12:30 PM
Taking the Guilt and "Weight" Out of Holiday Eating
The Holidays can be filled with warm memories, family and friends, but are often stressful due to endless delicious food tasting opportunities. This seminar will provide you with a non-dieting, guilt free approach to holiday eating - share in recipe ideas and tips on how to get through the holidays without the typical 10 lb weight gain. Led by Carolyn Gundell, MS and Cynthia Murdock, MD.
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Affording Treatment|News/Events|Resources|About Us|IVF Success Rates|IUI Success Rates|Fertility Success Rates|Contact|Site Map
70 Maple Avenue, Rye, New York (NY) 10580
600 Westage Business Center Drive, Fishkill, New York (NY) 12524
Yonkers | Greenburgh | New Rochelle | Mount Vernon | White Plains | Rye | Mount Pleasant | Yorktown | Ossining | Eastchester |Mamaroneck | Port Chester | Harrison | Peekskill | Baldwin | Somers |Bedford | Scarsdale | Jefferson Valley | South Salem | Pelham | Dobbs Ferry | Tarrytown | Mount Kisco |Sleepy Hollow
Carmel | Lake Peekskill | Southeast |Kent
Patterson | Putnam Valley | Mahopac | Brewster
Poughkeepsie | East Fishkill | Wappinger Falls | Fishkill | Hyde Park | LaGrange | Beacon | Arlington |Red Hook
10 Glover Avenue, Norwalk, Connecticut (CT) 06850
67 Sand Pit Road, Suite 300, Danbury, Connecticut (CT) 06810
1290 Summer Street, Suite 3200, Stamford, CT 06905
Bridgeport | Stamford | Norwalk | Danbury | Greenwich |Fairfield
Stratford | Shelton | Trumbull | Newtown | Westport |Ridgefield | Darien | New Canaan | Monroe | Bethel | Wilton |Brookfield | New Fairfield |Weston
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Call 800-865-5431 to schedule an appointment
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text:
Weed Biology
Part 2, Section 1: Pest Management
Pest Management
Weed Management
Weed biology
Weeds are grouped into three categories based on their life cycles. Annuals complete their life cycle within one year and reproduce from seed. Winter annuals germinate in the fall and complete their reproductive cycle in the spring or early summer. These weeds are more likely to be found in alfalfa, winter-sown grains, no-till crops, or pastures where the soil is not disturbed over the winter. Summer annuals germinate in the spring and set seed in late summer or fall. Summer annuals thrive when summer annual crops like corn or soybeans are grown. They compete directly with the crop for resources.
Biennials live during two growing seasons. The first year consists of vegetative growth, while the second year involves both vegetative and reproductive growth. Biennials also reproduce from seed. Because these weeds require two years to complete their life cycles, they are found in areas of low soil disturbance such as waterways, pastures, alfalfa, and fence rows.
Perennial plants live for more than two years. Reproduction can occur by seed production or vegetatively by structures such as rhizomes, tubers, bulbs, or budding roots. Although perennial weeds are most prevalent in areas of reduced soil disturbance, some are well adapted to row crops. Managing perennial weeds is generally more difficult because of their multiple reproductive systems.


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Tag Archives: iPharmaConnect
Pharma's Chaos Scenario: Why the Old Commercial Model Just Won't Cut It
By Guest Blogger | Published: March 2, 2012
By Peter Houston, Director of Content, Advanstar Communications. A couple of years ago I spoke at a Life Sciences Forum organized by Oracle. The audience was 100-percent life science and IT professionals, but I spoke about the magazine business. Why? Cynics say because I don't know enough about science or IT, but really it was […]
Posted in Guest Blog, social media, Technology | Also tagged Chaos Scenario, digital pharma | Leave a comment


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- Visit the Aquarium
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Join us - and some of our African penguins - Saturday, February 15, 2014 from 6:30 pm to 9:30 pm for a South African Wine Dinner amidst our beautiful indoor exhibits.
Enjoy exceptional South African wines, passed hors d'oeuvres and a 4-course sit-down plated dinner by Ocean Blue Catering. Cost is $59.95 per person, all-inclusive.
Please note that this event is sold out.
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One of the most popular private detectives ever, red-haired Miami P.I. MICHAEL SHAYNE has had a long, successful, multi-media career. Shayne was created and first appeared in the 1939 novel, Dividend on Death, by Davis Dresser, published under the pseudonym Brett Halliday. Dresser wrote fifty Shayne novels (with a little help from ghostwriters such as Ryerson Johnson) and twenty-seven more were written by Robert Terrall and published as paperback originals by Dell, still under the pseudonym Brett Halliday. So that's 77 novels, over 300 short stories, a dozen films, radio and television shows and even a few comic book appearances.
Because of his omnipresence, more than one wag has ventured to call Mike the "Generic Private Eye" but that may be missing the point. The Everyman Detective might be more apt.
According to author L.J. Washburn, "Shayne may have ended up that way, but he certainly didn't start out like that. The first half-dozen or so Shayne novels are unlike anything else in the genre I've read, a cross between hard-boiled private eye, screwball comedy, and fair-play detection. The screwball angle comes from Phyllis Shayne, Mike Shayne's beautiful young wife, and their relationship is much like what would have happened if Sam Spade had married Pam North (for those of you who remember Pam and Jerry North). The books are very well plotted, and Shayne even gathers the suspects in the end to explain the crime and name the murderer, just like Nero Wolfe or Ellery Queen. However, Phyllis was something of a limited character, so Dresser got her out of town (and off screen) in a couple of books, then killed her off when he sold the movie rights to the series. However, that led to maybe the best book in the series, Blood on the Black Market, in which all the comedy angles disappear and Shayne has to deal with Phyllis's death. Shayne's characterization in this book is a definite forerunner to such characters as Nameless and Matt Scudder.
Of course, after that the Shayne novels do tend to become more standard private eye fare, but I think some of those early novels are very worth of rediscovery." Washburn can certainly claim to know her stuff, having written, or co-written (with her husband, fellow crime writer James M. Reasoner) thirty-seven Mike Shayne stories under the pseudonym of Brett Halliday for Michael Shayne Mystery Magazine (later to be known as Mike Shayne Mystery Magazine) which had been introduced in 1956 by Renown Publications. It continued for almost three decades as one of the few digests to offer detective fiction of a noticeably harder type than was generally available. Each issue featured a Mike Shayne story by Brett Halliday, ranging from 7500 word short stories to 20,000 word novellas.
However, this "Brett Halliday" was not Davis Dresser, but a house name used by a variety of other writers, several of them quite accomplished detective writers themselves, including Dennis Lynds (aka Michael Collins, the most prolific, with 88 stories), Sam Merwin Jr. (the magazine's first editor), Michael Avallone, Richard Deming, Robert Turner, Robert Arthur, Frank Belknap Long, Bill Pronzini and Jeff Wallman, Edward Y. Breese, Peter Germano, Hal Blythe and Charlie Sweet, Hal Charles and James Reasoner.
In fact, Halliday also gave up writing the Shayne novels in 1958 with Murder and the Wanton Bride, although of course it continued, being ghosted by such other writers as Robert Terrall, Ryerson Johnson and Dennis Lynds. One of the ingredients of the formula Halliday had concocted in 1939, and to which he had faithfully adhered during his tenure as Shayne's writer, was a certain timeless quality. This fact allowed Shayne's other writers to bring him well into the 1980s.
But no matter who was doing the writing, Michael Shayne proved to be a popular character, not only in print, but in film, radio and even television. In 1940, the first of a long string of films, with Lloyd Nolan playing Shayne as a cocky, wise-cracking chucklehead, made its debut and set the pattern for a dozen or so more, although later on in the series High Beaumont took over the role.
A radio show featuring Mike debuted on Mutual as a West Coast regional in October 1944 with Wally Maher in the lead. Although mystery writer Brett Halliday got the credit for creating this detective and bringing him to radio, he never wrote any scripts but was happy enough to pick up the royalty checks. There were three separate versions of this show over the years.
In October 1946 it went coast-to-coast, lasting until November 1947. It was resurrected on Mutual in July 1948, under the title of "New Adventures of Michael Shayne" with Jeff Chandler in the lead, and it ran for two years. The last version began in October 1952 on ABC, first with Donald Curtis playing Shayne, and later with Robert Sterling. This third and last series went off the air in July 1953.
In all versions, Shayne was "that reckless, red-headed Irishman" Halliday originally described, who used brain and brawn equally, though the writers tended to have Mike take the physical approach to solving most problems. Easier to write, I guess. His assistant, a lovely blonde named Phyl Knight, was not prominent in most of the episodes. About 30 programs (most starring Chandler) are in trading currency today.
And in 1960, Michael Shayne moved onto television, with Richard Denning playing Shayne.
The television show was popular enough that a Dell comic book soon followed, a tie-in with the show, although the comics were actually based on Brett Halliday novels, not mere adaptations of T.V. episodes. The first issue adapted The Private Practice of Michael Shayne; the second adapted Bodies Are Where You Find Them, wherein a woman ends up dead in Shayne's bed amid speculation on what she was doing there in the first place (They always claimed "Dell Comics are GOOD comics."); and the third issue featured Heads...You Lose, where Phyllis dies in childbirth. I've always wondered what made Dell choose to go this route. Those early Halliday novels contained material that wasn't normally found in "good" comics -- drugs abounded, adultery was rampant, and the shortages in America during World War II were noted. Dell made similar decisions with Ed McBain's 87th Precinct comics.
Respectfully submitted by Kevin Burton Smith. Radio information contributed by Jack French, and comic info contributed by Don McGregor. And thanks for the "Gotcha!"'s from J. Ken MacDonald, Brendan Riley and Adam Lounsbery.
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Daily entries from the 17th century London diary
The overlays that highlight 17th century London features are approximate and derived from:
Chitterne is a village and parish in the County of Wiltshire, in the south west of England. The village lies in the middle of Salisbury Plain, to the south of the abandoned village of Imber. Its closest major settlements are Warminster and the city of Salisbury....Chitterne was one of the many Wiltshire estates owned in the 12th century by Ela, 3rd Countess of Salisbury. http://en.wikipedia.org/wiki/Chitterne
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Samsung Galaxy S III to launch in April?
The official word on the most hotly anticipated phone for 2012 is that it will launch in the first half of 2012. When exactly is anyone's guess but clever money would be on June to coincide with any Apple releases that may or may not happen.
There are rumours a plenty about the new god-phone, capacitive changing, incredible displays etc. etc. but so far not even a squeak of "official" confirmation.
However unofficially there is discussion that a launch could be as soon as April. The news comes via Maeli Business News, which cites Samsung Greater China President, Kim Young-Ha.
The revised timescale was mentioned during a press conference.
Rumoured Samsung Galaxy S III specs are: display: somewhere in the 4.6-4.8in region, camera: 8-12MP , NFC for contactless payments, a quad-core Exynos processor, and Ice Cream Sandwich (Android 4.0).


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Imagination is the formation of mental images and/or concepts that are not present to the senses. It is the process of thinking of things in a different way than they actually exist. It is a creation of the mind that normally does not have a direct correspondence to actuality.
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Members are reminded that entries for the Youth/Master/Veteran and Open State Target events close this Monday 22nd September.Read more
This year, both the open championships and youth, veteran, masters championships will be shot in reverse order (shorter distances first). All distances will be shot using 6 arrow ends. Target allocations...Read more
Results now available.Read more
Free car parking space at Sydney Olympic Archery Park is limited. To assist participants Sydney Olympic Park Authority are providing a flat daily rate of $14 at the P5 parking. ...Read more
On Saturday there were 13 State and National Records shot for the Unmarked field. Today there was record and one equal record shot in the Marked field. Westlakes Archers should be...Read more
Target Allocations now available...Read more
Archery NSW is proud to announce that Benson Archery has come on board as a sponsor.Read more
The Short Corse Championship is rescheduled for 8th September 2013. Previous registered entrants are requested to reconfirm they are entering the rescheduled event.Read more
7pm, 30th August 2013. Tasman Room, Sports House, 6 Figtree Road, Homebush.Read more
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GRAPHIC DESIGN NEEDED TO HELP WITH DESIGN IMAGES (UNPAID) School Credit AvailableAlzerina.com
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KayKin Music
DescriptionKayKin Music, an independent record label and music publishing company that fosters timeless music. Through artist development, quality production, marketing and sound business acumen, KayKin Music's presence will be felt throughout the entertainment industry.
With that said, KayKin Music is looking for candidates who are in search of an opportunity to express their creativity as it relates to Website Design, Logo Design and Promotional Items. I know what I want, but more importantly, I want to know what you have to offer. When it is all said and done, you will be credited with every success that comes with your work. I am just giving an opportunity for potential candidates to shine.
Responsibilities- Assists in the design and development of layouts for marketing materials, using appealing graphics that are well organized
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30th Oct 2001, 02:38 PM
I'm writing a little something (I don't want to make a joke of myself by mentioning what it actually is and then failing to complete it) and I need to check whether it's currently on top of something else, especially the world geometry. Checking whether Base is None didn't work; neither did tracing downwards a little bit further than the CollisionHeight, the latter logically because the thing could be standing on top of something with only part of its cylinder, but not its center. Can anybody help?


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We've spent quite a bit of time trying to develop a framework to understand and frame the Drupal7 Audience in such a way as we can successfully design for them. We thought you might be interested in seeing some of our thinking to date, so we recorded a quick chat about it in the video above. (I really should do my hair before videoing myself!)
As an overview, here is the outline of what we're thinking:
There are three important user attributes: role, type of site, and size/complexity of the user ecosystem(number of users in the system and no. of different roles defined).
Important roles:
- end user (define here)
- editor
- site builder
- site administrator
Important site types:
- blog
- news/publishing
- groups
- events
Important ecosystems
- single user
- 2-5 users
- 5-15 users
-more than 15 users
(need to work out a way to define number of user roles as well)
This is still very much work in progress and there is more thinking to be done – stay tuned. Meanwhile, I think we need to come up with a fancy word for our little audience prototype thingy.
[x-posted at http://groups.drupal.org/node/20073]


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Oven-baked sweet potato fajitas
By Lucy Netherton
Cooking timePrep: 10 mins Cook: 40 mins
Skill levelEasy
ServingsServes 4
Vegetarians needn't miss out on the joy of tortilla wraps- we use peppers, onions and sweet potato topped with feta and soured cream
Nutrition and extra info
Additional info
- Vegetarian
Nutrition info
Nutrition per serving
- kcalories
- 544
- protein
- 16g
- carbs
- 96g
- fat
- 10g
- saturates
- 5g
- fibre
- 9g
- sugar
- 26g
- salt
- 2.9g
- 2 large sweet potatoes
- 1 onion
- 2 red onions
- 1 large red pepper, deseeded
- 1 tbsp vegetable oil
- 2 tbsp cider or white wine vinegar
- 30g sachet fajita seasoning
- 8 small tortilla wraps
- ½ small pack coriander, chopped
- ½ small pot low-fat soured cream
- small iceberg lettuce, shredded
- 100g reduced-fat feta cheese, crumbled
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- Heat oven to 200C/180C fan/gas 6. Chop the veg into chunky wedges and toss in a large bowl with the oil, vinegar and fajita seasoning. Arrange in a single layer on a large baking tray and cook for 40 mins, turning halfway through.
- Meanwhile, warm the wraps following pack instructions. Once the veg is cooked, sprinkle with coriander, then roll up in the wraps with a dollop of soured cream, some lettuce and crumbled feta on top.
Recipe from Good Food magazine, September 2013
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Evaluation of a Human Bio-Engineered Skin Equivalent for Drug Permeation Studies
- Charles Asbill,
- Nanhye Kim,
- Ayman El-Kattan,
- Kim Creek,
- Philip Wertz,
- Bozena Michniak
- … show all 6 hide
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Purpose. To test the barrier function of a bio-engineered human skin (BHS) using three model drugs (caffeine, hydrocortisone, and tamoxifen) in vitro. To investigate the lipid composition and microscopic structure of the BHS.
Methods. The human skin substitute was composed of both epidermal and dermal layers, the latter having a bovine collagen matrix. The permeability of the BHS to three model drugs was compared to that obtained in other percutaneous testing models (human cadaver skin, hairless mouse skin, and EpiDerm™). Lipid analysis of the BHS was performed by high performance thin layered chromatrography. Histological evalulation of the BHS was performed using routine H&E staining.
Results. The BHS mimicked human skin in terms of lipid composition, gross ultrastructure, and the formation of a stratum corneum. However, the permeability of the BHS to caffeine, hydrocortisone, and tamoxifen was 3-4 fold higher than that of human cadaver skin.
Conclusions. In summary, the results indicate that the BHS may be an acceptable in vitro model for drug permeability testing.
Article MetricsCitations
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- R. L. Bronaugh and H. I. Maibach. In Vitro Percutaneous Absorption: Principles, Fundamentals and Applications, Boca Raton, Fl, CRC Press (1991).
- R. Panchagnula, K. Stemmer, and W. A. Ritschel. Animal models for transdermal drug delivery. Methods Find Exp. Clin. Pharmacol. 19:335–341 (1997).
- M. Ponec, M. Haverkort, Y. L. Soei, J. Kempenaar, and H. Bodde. Use of human keratinocyte and fibroblast cultures for toxicity studies of topically applied compounds. J. Pharm. Sci. 79:312–316 (1990).
- D. A. Godwin, B. B. Michniak, and K. E. Creek. Evaluation of transdermal penetration enhancers using a novel skin alternative. J. Pharm. Sci. 86: 1001–1005 (1997).
- I. V. Yannas, J. F. Burke, M. Warpehoski, P. Stasikelis, E. M. Skrabut, and D. P. Orgill. Design principles and preliminary clincial performance of an artificial skin. In Biomaterials: Interfacial Phenomena and Applications. 1982, pp. 476–481.
- J. F. Morgan and M. L. Yarmush. Bioengineered skin substitutes. Science & Medicine. 6–15 (1997).
- M. Muhart, S. McFalls, R. Kirsner, F. Kerdel, and W. H. Eaglstein. Bioengineered skin [letter]. Lancet. 350:1142 (1997).
- T. J. Phillips. New skin for old: Developments in biological skin substitutes [editorial; comment]. Arch. Dermatol. 134:344–349 (1998).
- J. F. Trent, R. S. Kirsner. Tissue engineered skin: Apligraf, a bilayered living skin equivalent. Int. J. Clin. Pract. 52:408–413 (1998).
- J. G. Rheinwald and H. Green. Serial cultivation of strains of human epidermal keratinocytes. The formation of keratinizing colonies from single cells. Cell 6:331–343 (1975).
- E. Bell, H. P. Ehrlich, D. J. Buttle and T. Nakatsuji. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science 211: 1052–1054 (1981).
- M. Rosdy, B. Grisoni, and L. C. Clauss. Proliferation of normal human keratinocytes on silicone substrates. Biomaterials 12:511–517 (1991).
- V. H. Mak, M. B. Cumpstone, A. H. Kennedy, C. S. Harmon, R. H. Guy, and R. O. Potts. Barrier function of human keratinocyte cultures grown at the air-liquid interface. J. Invest. Dermatol. 96:323–327 (1991).
- N. Kim, M. El-Khalili, M. M. Henary, L. Strekowski, and B. B. Michniak. Percutaneous penetration enhancement activity of aromatic S, S-dimethyliminosulfuranes. Int. J. Pharm. 187:219–229 (1999).
- B. B. Michiak, M. R. Player, J. M. Chapman, and J. W. Sowell. In vitro evaluation of a seies of Azone analogs as dermal penetration enhancers: I. Int. J. Pharm. 91:85–93 (1993).
- L. C. Fuhrman, B. B. Michniak, C. R. Behl, and A. W. Malick. Effect of novel penetration enhancers on the transdermal delivery of hydrocortisone: an in vitro species comparison. J. Control. Rel. 45:197–204 (1996).
- I. H. Blank, R. J. Scheuplein, and D. J. MacFarlane. Mechanism of percutaneous absorption. 3. The effect of temperature on the transport of non-electrolytes across the skin. J. Invest. Dermatol. 49:582–589 (1967).
- C. A. Squier, P. Cox, and P. W. Wertz. Lipid content and water permeability of skin and oral mucosa. J. Invest. Dermatol. 96:123–126 (1991).
- D. T. Downing, M. E. Stewart, P. W. Wertz, S. W. Colton, W. Abraham, and J. S. Strauss. Skin lipids: an update. J. Invest. Dermatol. 88:2s–6s (1987).
- P. W. Wertz and D. T. Dowing. Stratum Corneum: Biological and biochemical considerations. In Transdermal Drug Delivery, J. Hadgraft and Richard H. Guy. Eds, Markel Dekker Inc., New York, 1989, pp. 1–22.
- M. Ponec, A. Weerheim, J. Kempenaar, A. M. Mommaas, and D. H. Nugteren. Lipid composition of cultured human keratinocytes in relation to their differentiation. J. Lipid Res. 29:949–961 (1988).
- M. Ponec. Reconstruction of human epidermis on deepidermized dermis: Expression of differentiation-specific protein markers and lipid composition, Toxicol. in Vitro. 5:597–606 (1991a).
- P. W Wertz, and D. T. Downing. Glucosylceramides of pig epidermis: Structure determination. J. Lipid Res. 24:1135–1139 (1983).
- P. W. Wertz and D. T. Downing. Acylglucosylceramides of pig epidermis: structure determination. J. Lipid Res. 24:753–758 (1983).
- Title
- Evaluation of a Human Bio-Engineered Skin Equivalent for Drug Permeation Studies
- Journal
Pharmaceutical Research
Volume 17, Issue 9 , pp 1092-1097
- Cover Date
- 2000-09-01
- Print ISSN
- 0724-8741
- Online ISSN
- Publisher
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Topics
- Keywords
- drug delivery systems
- skin alternatives
- transdermal drug delivery
- permeability
- Industry Sectors
- Authors
- Charles Asbill (1)
- Nanhye Kim (1)
- Ayman El-Kattan (1)
- Kim Creek (2)
- Philip Wertz (3)
- Bozena Michniak (4)
- Author Affiliations
- 1. Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, South Carolina
- 2. Children's Cancer Research Laboratory, Department of Pediatrics and Department of Pathology, University of South Carolina School of Medicine, South Carolina
- 3. Dows Institute, University of Iowa, Iowa
- 4. Department of Basic Pharmaceutical Sciences College of Pharmacy, University of South Carolina, 700 Sumter Street, Columbia, South Carolina, 29208


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The Empire State Building The Empire State Building, once again the tallest skyscraper in town, seems lonely. But the 1931 Art Deco landmark (which survived a 1945 crash by a B-25 bomber) continues to anchor Midtown with dignity, sturdiness and style.
For the full article, check out the new issue of Wine Spectator, on newsstands April 30, 2002.
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Guide to Monroe Ave N & Belknap
The energy behind downtown's rebirth isn't just limited to the heart of the city; it's also beginning to make its way into the Belknap-Monroe area located just to the north. Bordered by the Grand River to the west, Leonard Street on the north and College and Crescent to east and south, the neighborhood is home to three unique sections.
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John Edwards' affair was reported in the National Enquirer last October. Why doesn't the mainstream media ever give credence to a single story based on unsubstantiated rumors? (3:11)
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Smarter Decisions,
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UpToDate synthesizes the most recent medical information into evidence-based practical recommendations clinicians trust to make the right point-of-care decisions.
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|AuthorsRavi I Thadhani, MD, MPHSharon E Maynard, MD
|Section EditorRichard J Glassock, MD, MACP
|Deputy EditorVanessa A Barss, MD, FACOG
Topic Outline
In non-pregnant individuals, abnormal total protein excretion is typically defined as greater than 150 mg daily. In normal pregnancy, urinary protein excretion increases substantially, due to a combination of increased glomerular filtration rate and increased permeability of the glomerular basement membrane [1]. Hence, total protein excretion is considered abnormal in pregnant women when it exceeds 300 mg/24 hours [2].
Proteinuria is one of the cardinal features of preeclampsia (table 1), which is a common and potentially severe complication of pregnancy. However, two important points should be noted. First, the severity of proteinuria is not indicative of the severity of preeclampsia and should not be used to guide management [3-5]. Second, although part of the formal diagnostic criteria of preeclampsia, proteinuria may be absent. Studies have shown that 10 percent of women with clinical and/or histological manifestations of preeclampsia have no proteinuria and 20 percent of women with eclampsia do not have significant proteinuria prior to their seizure [6,7].
Although less prevalent, primary renal disease and renal disease secondary to systemic disorders, such as diabetes or primary hypertension (formerly called "essential" hypertension), are also usually characterized by proteinuria and may first present in pregnancy. To further complicate this picture, 20 to 25 percent of women with chronic hypertension and diabetes develop superimposed preeclampsia [8,9].
It is important for clinicians caring for pregnant women to understand how to identify proteinuria, and how to determine whether preeclampsia or renal disease (or both) is the cause. This topic will discuss the approach to the evaluation of pregnant women with proteinuria and management of nephrotic syndrome in pregnancy. The evaluation of proteinuria in nonpregnant individuals and measurement of protein excretion are discussed in detail separately. (See "Assessment of urinary protein excretion and evaluation of isolated non-nephrotic proteinuria in adults".)
Glomerular filtration rate (GFR) and renal blood flow rise markedly during pregnancy, resulting in a physiologic fall in the serum creatinine concentration. As discussed above, urinary protein excretion increases substantially due to a combination of increased GFR and increased permeability of the glomerular basement membrane [1]. Women with uncomplicated twin pregnancies have greater increases in urinary protein excretion than do women with singleton pregnancies [10]. Additional information on pregnancy-related changes in renal function and the urinary tract can be found separately. (See "Renal and urinary tract physiology in normal pregnancy".)
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The U.S. Environmental Protection Agency has $1 million available to assist tribal governments in reducing emissions from older diesel engines, including from school buses, as part of the Diesel Emissions Reduction Act.
EPA said this year's program is the first time it has offered a separate Request for Proposal opportunity to these communities. EPA added the program resulted from feedback from these tribal communities for their own specific grants. Proposals must be received by Aug. 12. Information can be accessed on the National Clean Diesel Campaign Tribal page.
EPA is also hosting informational webinars about the DERA Tribal RFP on June 12, 17, and 19 at 3 p.m. Eastern.
Meanwhile, proposals for $9 million in other DERA money are due June 17.


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In its latest attempt to postpone Wednesday's trial of the former military commander of the Bosnian Serbs, the defence team for Ratko Mladic appealed Monday for a six-month delay in the start of his war crimes trial, saying delays by prosecutors in disclosing evidence could lead to a miscarriage of justice. The move follows their calls last week for presiding Judge Alphons Orie to be replaced.
By Maaike van Breevoort, Hilversum
Mladic's defence "respectfully moves for the disqualification of judge Orie in order to restore the integrity of the proceedings," said lawyer Branko Lukic in a petition published on the website of the International Criminal Tribunal for the former Yugoslavia (ICTY) in The Hague.
The defence team called for the postponement of the opening of the trial to allow time for its request to be considered. But Tribunal officials say the trial is on schedule to start Wednesday.
According to the defence request, presiding Judge Orie cannot be impartial because he has been involved in the convictions of several former Mladic subordinates for the same crimes Mladic is now charged with. Defence lawyers argue that Orie has a "personal interest" to see that his findings in previous cases remain intact.
Who is Alphons Orie?
Alphons Orie started working for the ICTY as a defence lawyer for Bosnian Serb Dusko Tadic, the first person tried and convicted by the ICTY.
In one of its 17 complaints against Orie's suitability to preside over the trial, Mladic's lawyers argue that there is a conflict of interest because the current case is partly based on the same allegations for which his former client was convicted.
Mladic's lawyers also suggest that Orie should withdraw from the case because his Dutch nationality makes him too biased to handle the Srebrenica genocide charges against their client.
More than 7,000 Muslims were killed during the 1995 Srebrenica massacres. Prosecutors say Mladic commanded the troops who massacred them in warehouses, forests, fields and cultural centers over five days in July 1995.
It was Dutch UN troops who were on guard when the massacres took place. Some of them were taken hostage by the Bosnian Serbs--crimes Mladic now stands charged with. Because Orie is Dutch, Mladic's lawyers argue he is unfit to hear the case.
Radovan Karadzic, the former political chief of Mladic, made a similar complaint in 2008. Judge Orie was then removed from the trial by the court in what officials termed "administrative" reasons and not in response to Karadzic's complaint.
The removal from Karadzic's case also occurred in a more preliminary phase of the proceedings, not mere days before the opening of the trial.
Mladic has repeatedly attempted to postpone the beginning of the trial in which he faces 11 counts of international crimes including genocide, crimes against humanity and war crimes.


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Star 15SG Sneeze Guard for 15NCPW Popcorn / Nacho Warmer
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Star 15NCPW 15" Popcorn / Nacho Warmer
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Diddy presents at CMA Awards
JUST ADDED: 5 Seconds of Summer will be rocking the stage at this year's iHeartRadio Music Festival Village in Las Vegas! The band sat down with Ryan Seacrest to break the news.�Click here to buy your tickets now, before they sell out!
Check out the full lineup for this year's iHeartRadio Music Festival
Listen to Diddy on iHeartRadio
Diddy is declaring his support for country music. At Wednesday's 47th Annual CMA Awards on ABC, the hip-hop mogul helped present the award for Vocal Group of the Year with Kellie Pickler and revealed that he's been a country fan in hiding.
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Diddy didn't pass up the opportunity to plug his newly launched TV network Revolt TV. He explained to the country crowd that he started the network to promote all genres of music because today's young people aren't picky about what type of tunes they listen to.
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Dubbed the "new number one name in music," Diddy promises that Revolt will be dedicated to connecting artists with their fans.
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