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Summary: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
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Publications248 found, 100 shown here
- Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosaA P Fonseca
Department of Microbiology, Faculty of Medicine, University of Porto, Portugal
J Med Microbiol 53:903-10. 2004..This study investigated the ability of sub-MIC piperacillin/tazobactam (P/T) to interfere with the bacterial virulence parameters of adhesiveness, cell-surface ..
- Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shockFabio Silvio Taccone
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
Crit Care 14:R126. 2010..The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients ..
- Clinical efficacy of continuous infusion of piperacillin compared with intermittent dosing in septic critically ill patientsMohammad Reza Rafati
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Iran
Int J Antimicrob Agents 28:122-7. 2006..of continuous infusion therapy, we evaluated the outcomes for 40 septic critically ill patients who received piperacillin either continuously (2 g intravenously (i.v.) over 0.5 h as a loading dose followed by 8 g i.v...
- Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusionLeonardo Lorente
Intensive Care Unit, Hospital Universitario de Canarias, Ofra s n, La Cuesta, La Laguna 38320, Tenerife, Spain
Int J Antimicrob Agents 33:464-8. 2009The standard mode of administration of piperacillin treatment is by intermittent infusion. However, continuous infusion may be advantageous as beta-lactam antibiotics exhibit time-dependent antibacterial activity...
- Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategyThomas P Lodise
Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208, USA
Clin Infect Dis 44:357-63. 2007b>Piperacillin-tazobactam is frequently used to treat Pseudomonas aeruginosa infections in critically ill patients...
- Efficacy and tolerability of piperacillin/tazobactam versus ceftazidime in association with amikacin for treating nosocomial pneumonia in intensive care patients: a prospective randomized multicenter trialF Alvarez-Lerma
Intensive Care Unit, Hospital del Mar, Autonomous University of Barcelona, Passeig Maritim 25 29, 08003 Barcelona, Spain
Intensive Care Med 27:493-502. 2001..and bacteriological efficacy as well as tolerability of two regimens of broad-spectrum antibiotics (ceftazidime versus piperacillin/tazobactam) combined with amikacin in the treatment of nosocomial pneumonia in intensive care patients.
- Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosisSabah El-Ghaiesh
Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, Sherrington Building, Ashton Street, University of Liverpool, Liverpool, L69 3GE, United Kingdom
J Pharmacol Exp Ther 341:597-610. 2012..The objective of this study was to use cloned T-cells expressing a single T-cell receptor from five piperacillin-hypersensitive patients to characterize both the cellular pathophysiology of the reaction and antigen ..
- Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infectionChonghua Li
Center for Anti Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
J Antimicrob Chemother 56:388-95. 2005We investigated the population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam in hospitalized patients.
- Endocarditis caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibilityOren Zimhony
Division of Infectious Diseases, Kaplan Medical Center Rehovot, Hebrew University and Hadassah, Jerusalem, Israel
Antimicrob Agents Chemother 50:3179-82. 2006..The second isolate developed resistance to ciprofloxacin and the third isolate to piperacillin-tazobactam (PIP-TZ) following sequential therapy with each agent...
- Distinct synergistic action of piperacillin and methylglyoxal against Pseudomonas aeruginosaSayanti Mukherjee
Department of Microbiology, Herbicure Healthcare Bio Herbal Research Foundation, 7 and 8 Metro Garden City, D H Road, Pailan, Kolkata 700 104, India
Indian J Exp Biol 49:547-51. 2011..aeruginosa infections. Results revealed that the strains were resistant to many drugs at high levels, only piperacillin, carbenicillin, amikacin and ciprofloxacin showed resistances at comparatively lower levels...
- A randomized trial of the efficacy and safety of sequential intravenous/oral moxifloxacin monotherapy versus intravenous piperacillin/tazobactam followed by oral amoxicillin/clavulanate for complicated skin and skin structure infectionsInge C Gyssens
Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Antimicrob Chemother 66:2632-42. 2011The primary aim of the RELIEF study was to evaluate the efficacy and safety of two sequential intravenous (iv)/oral regimens: moxifloxacin iv/oral versus piperacillin/tazobactam (TZP) iv followed by oral amoxicillin/clavulanate (AMC).
- Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin-tazobactam monotherapyA Cometta
Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
Clin Infect Dis 37:382-9. 2003..in neutropenic patients with cancer who had persistent fever 48-60 h after the initiation of empirical piperacillin-tazobactam monotherapy...
- Expanded studies of piperacillin/tazobactam formulations: variations among branded product lots and assessment of 46 generic lotsGary J Moet
JMI Laboratories, North Liberty, IA 52317, USA
Diagn Microbiol Infect Dis 65:319-22. 2009The experience with analyzing the potency of piperacillin/tazobactam generic formulations by a precise multiorganism in vitro assay was expanded to 46 lots (29 manufacturers, 17 countries)...
- Risk factors for piperacillin-tazobactam-resistant Pseudomonas aeruginosa among hospitalized patientsAnthony D Harris
Department of Epidemiology and Preventive Medicine, University of Maryland VA Maryland Health Care System, Baltimore, Maryland 21201, USA
Antimicrob Agents Chemother 46:854-8. 2002..This study determined risk factors for the recovery of piperacillin-tazobactam-resistant P. aeruginosa from clinical cultures from hospitalized patients...
- Impact of antibiotic restriction on broad spectrum antibiotic usage in the ICU of a developing countryShahla Siddiqui
Department of Anaesthesia, Aga Khan University, Karachi
J Pak Med Assoc 57:484-7. 2007..To reduce rates of nosocomial pneumonia and cost of antibiotic therapy...
- First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsisJason A Roberts
Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
Int J Antimicrob Agents 35:156-63. 2010..of this study were (i) to compare the plasma concentration-time profiles for first-dose and steady-state piperacillin administered by intermittent or continuous dosing to critically ill patients with sepsis and (ii) to use ..
- Pharmacokinetics of piperacillin-tazobactam: intermittent dosing versus continuous infusionChristine Buck
Department of General Internal Medicine, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Int J Antimicrob Agents 25:62-7. 2005..treatment were randomly assigned to receive the beta-lactam antibiotic/beta-lactamase inhibitor combination piperacillin-tazobactam either as an intermittent or as a continuous infusion...
- Replacement of broad-spectrum cephalosporins by piperacillin-tazobactam: impact on sustained high rates of bacterial resistanceCarlos Bantar
Committee for Prevention and Control of Nosocomial Infection, Hospital San Martin, Parana, Entre Rios, Argentina
Antimicrob Agents Chemother 48:392-5. 2004..Therefore, we sought to determine whether replacement of CEP by piperacillin-tazobactam might be useful in reducing sustained high rates of CEP resistance by this organism...
- A randomized, open-label, multicenter comparative study of the efficacy and safety of piperacillin-tazobactam and cefepime for the empirical treatment of febrile neutropenic episodes in patients with hematologic malignanciesE J Bow
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Clin Infect Dis 43:447-59. 2006..This study was performed to demonstrate the noninferiority of monotherapy with piperacillin-tazobactam, compared with cefepime.
- Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing EnterobacteriaceaeK S Thomson
Center for Research in Antiinfectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
Antimicrob Agents Chemother 45:3548-54. 2001There is little information about the clinical effectiveness of cefepime and piperacillin-tazobactam in the treatment of infections caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens...
- Serological studies of piperacillin antibodiesRegina M Leger
American Red Cross Blood Services, Southern California Region, Pomona, California 91768, USA
Transfusion 48:2429-34. 2008..Antibodies to piperacillin, a semisynthetic penicillin, would be expected to react similarly; however, antipiperacillin can be detected by ..
- Influence of renal function on trough serum concentrations of piperacillin in intensive care unit patientsJean Marie Conil
Laboratoire de Cinétique des Xénobiotiques, UMR 181 Physiopathologie et Toxicologie Expérimentale, Faculté des Sciences Pharmaceutiques de Toulouse, Toulouse, France
Intensive Care Med 32:2063-6. 2006To explore the effects of renal function estimated by measured creatinine clearance (Cl(CR)) on trough serum concentration (C(min)) of piperacillin given to critically ill patients.
- Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteersJ B Bulitta
Institute for Biomedical and Pharmaceutical Research, Nürnberg Heroldsberg, Germany
Antimicrob Agents Chemother 51:2497-507. 2007..Treatment of Pseudomonas aeruginosa infection is often very problematic. Piperacillin-tazobactam has good activity against P...
- Clinafloxacin versus piperacillin/tazobactam in the treatment of severe skin and soft-tissue infections in adults at a Veterans Affairs medical centerFlora S Siami
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212 2637, USA
Clin Ther 24:59-72. 2002..Thus, there is a continuing search for reasonably safe, well-tolerated, and effective antimicrobial agents that are less susceptible to the development of resistance than older agents...
- The use of piperacillin-tazobactam in neonatal and paediatric patientsMaria F Wolf
University of Bonn, Children s Hospital, Medical Center, Department of Pediatric Hematology and Oncology, Adenauerallee 119, 53113 Bonn, Germany
Expert Opin Drug Metab Toxicol 5:57-69. 2009b>Piperacillin-tazobactam (PIP/TAZO) has been extensively used in adults with nosocomial infections and with fever and neutropenia. The available data considering the use of PIP/TAZO have not been reviewed in detail.
- Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shockAndrea Giacometti
Institute of Infectious Diseases and Public Health, Clinica delle Malattie Infettive, Universita Politecnica delle Marche, c o Ospedale Regionale, Via Conca, 60020 Torrette AN, Ancona, Italy
Peptides 24:1747-52. 2003..animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin...
- A prospective, randomized study comparing cefozopran with piperacillin-tazobactam plus ceftazidime as empirical therapy for febrile neutropenia in children with hematological disordersTomonobu Sato
Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan
Pediatr Blood Cancer 51:774-7. 2008The aim of this randomized study was to evaluate the efficacy of cefozopran monotherapy and piperacillin-tazobactam plus ceftazidime (PIPC/TAZ + CAZ) combination therapy in pediatric neutropenic patients.
- Influence of renal function on the pharmacokinetics of piperacillin/tazobactam in intensive care unit patients during continuous venovenous hemofiltrationAlazne Arzuaga
Laboratorio de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Paseo de la Universidad no 7, 01006 Vitoria Gasteiz, Spain
J Clin Pharmacol 45:168-76. 2005The pharmacokinetics of piperacillin/tazobactam (4 g/0.5 g every 6 or 8 hours, by 20-minute intravenous infusion) were studied in 14 patients with acute renal failure who underwent continuous venovenous hemofiltration with AN69 membranes...
- Lack of pharmacokinetic drug interactions following concomitant administration of telavancin with aztreonam or piperacillin/tazobactam in healthy participantsShekman L Wong
Theravance, Inc, 901 Gateway Blvd, South San Francisco, CA 94080, USA
J Clin Pharmacol 49:816-23. 2009..study in healthy participants assessed pharmacokinetic interactions between telavancin, aztreonam, and piperacillin/tazobactam...
- Enhanced liposome-mediated antibacterial activity of piperacillin and gentamicin against gram-negative bacilli in vitroM C Nacucchio
, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
J Microencapsul 5:303-9. 1988This study showed that encapsulation of piperacillin (PIP) and gentamicin (GE) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) enhanced the antibiotic activity against gram negative bacilli...
- Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjectsGurudatt Chandorkar
Cubist Pharmaceuticals, Inc, 65 Hayden Avenue, Lexington, MA 02421, USA
J Antimicrob Chemother 67:2463-9. 2012..epithelial lining fluid (ELF) penetration of ceftolozane/tazobactam, which has potent in vitro activity against many Gram-negative pathogens causing nosocomial pneumonia, with that of piperacillin/tazobactam in healthy adult volunteers.
- Piperacillin-tazobactam monotherapy in high-risk febrile and neutropenic cancer patientsC Viscoli
University of Genova and the National Institute for Cancer Research, Genoa, Italy
Clin Microbiol Infect 12:212-6. 2006..In the present study, 763 eligible patients with fever and neutropenia received piperacillin-tazobactam monotherapy...
- Comparison of intravenous/oral ciprofloxacin plus metronidazole versus piperacillin/tazobactam in the treatment of complicated intraabdominal infectionsS M Cohn
Department of Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA
Ann Surg 232:254-62. 2000..the safety and efficacy of intravenous (IV) ciprofloxacin plus IV metronidazole (CIP+MET) with that of IV piperacillin/tazobactam (PIP/TAZO) in adults with complicated intraabdominal infections, and to compare the efficacy of ..
- Daily serum piperacillin monitoring is advisable in critically ill patientsNicolas Blondiaux
Pole de Microbiologie, Centre de Biologie Pathologie, Centre Hospitalier Régional Universitaire CHRU de Lille, Boulevard du Pr J Leclercq, F 59037 Lille, France
Int J Antimicrob Agents 35:500-3. 2010The aim of the present study was to evaluate the benefit of monitoring serum piperacillin concentrations in critically ill patients...
- A beneficial interaction between imipenem and piperacillin possibly through their renal excretory processHiroshi Saitoh
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, and Department of Pharmacy, Health Sciences University of Hokkaido Hospital, Japan
Biol Pharm Bull 29:2519-22. 2006In order to assess the beneficial mechanism of the concomitant use of imipenem (IPM) with piperacillin (PIPC) for the treatment of serious infectious diseases such as sepsis, the effects of PIPC on the uptake of IPM by rat renal cortical ..
- Treatment with a broad-spectrum cephalosporin versus piperacillin-tazobactam and the risk for isolation of broad-spectrum cephalosporin-resistant Enterobacter speciesMitchell J Schwaber
Department of Medicine, Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts, USA
Antimicrob Agents Chemother 47:1882-6. 2003..We compared the risk conferred by broad-spectrum cephalosporins to that conferred by piperacillin-tazobactam, alone or in combination with an aminoglycoside or a fluoroquinolone...
- Piperacillin-associated pulmonary infiltrates with eosinophilia: a case reportOlivia Ling I Tseng
Department of Internal Medicine, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia
Can Respir J 17:e24-6. 2010A case of pulmonary infiltrates with eosinophilia attributed to piperacillin tazobactam therapy is described. A 54-year-old woman was treated for a suspected severe urinary tract infection with piperacillin tazobactam...
- Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitisRoberto Ghiselli
Department of General Surgery, INRCA IRRCS, Universita Politecnica delle Marche, Ancona, Italy
Crit Care Med 36:240-5. 2008To investigate the efficacy of piperacillin/tazobactam combined with indolicidin in the prevention of lethality in two rat models of polymicrobial peritonitis.
- Piperacillin/tazobactam: a pharmacoeconomic review of its use in moderate to severe bacterial infectionsM Young
Adis International Limited, Auckland, New Zealand
Pharmacoeconomics 19:1135-75. 2001b>Piperacillin/tazobactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity against most Gram-positive and Gram-negative aerobic bacteria and anaerobic bacteria...
- Imipenem/cilastatin versus piperacillin/tazobactam plus amikacin for empirical therapy in febrile neutropenic patients: results of the COSTINE studyMiguel A Sanz
Servicio de Hematologia, Hospital Universitario La Fe, Valencia, Spain
Curr Med Res Opin 21:645-55. 2005..However, it is not clear whether such combinations are advantageous over therapy with a broad-spectrum antibiotic...
- Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?Jason A Roberts
Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
Crit Care Med 37:926-33. 2009To describe a pharmacokinetic model of piperacillin concentrations in plasma and subcutaneous tissue when administered by bolus dosing and continuous infusion in critically ill patients with sepsis on days 1 and 2 of antibiotic therapy ..
- Efficacy and safety of IV/PO moxifloxacin and IV piperacillin/tazobactam followed by PO amoxicillin/clavulanic acid in the treatment of diabetic foot infections: results of the RELIEF studyN C Schaper
Department of Internal Medicine, Division of Endocrinology, CARIM and CAPHRI Institute, Maastricht University Medical Center, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
Infection 41:175-86. 2013..The aim was to compare the efficacy and safety of two antibiotic regimens in patients with diabetic foot infections (DFIs)...
- Continuous infusion of piperacillin/tazobactam in ventilator-associated pneumonia: a pilot study on efficacy and costsWieslawa Duszynska
Department of Anesthesiology and Intensive Care, Wroclaw Medical University, Borowska Street 213, 50 556 Wroclaw, Poland
Int J Antimicrob Agents 39:153-8. 2012..b>Piperacillin/tazobactam (TZP) is currently recommended in the empirical treatment of VAP, but intermittent dosing may result ..
- Prospective drug utilization evaluation of three broad-spectrum antimicrobials: cefepime, piperacillin-tazobactam and meropenemD Raveh
Infectious Disease Unit, Shaare Zedek Medical Center, Jerusalem 91031, Israel
QJM 99:397-406. 2006Cefepime, piperacillin-tazobactam and meropenem are among the broadest-spectrum and most expensive antimicrobials.
- Therapeutic drug monitoring of piperacillin-tazobactam using spent dialysate effluent in patients receiving continuous venovenous hemodialysisMichael J Connor
Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio, USA
Antimicrob Agents Chemother 55:557-60. 2011..Here we present the first data demonstrating this approach for piperacillin-tazobactam...
- Low-dose beta-lactam plus amikacin in febrile neutropenia: cefepime vs. piperacillin/tazobactam, a randomized trialL Gomez
Infectious Diseases Unit, Hospital Universitari Mutua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain
Eur J Clin Microbiol Infect Dis 29:417-27. 2010..randomized trial to evaluate the efficacy of low-dose cefepime plus amikacin (C-A) compared to low-dose piperacillin/tazobactam plus amikacin (PT-A)...
- In vitro efficiency of the piperacillin/tazobactam combination against inhibitor-resistant TEM- and complex mutant TEM-producing clinical strains of Escherichia coliFrederic Robin
CHU Clermont Ferrand, Centre de Biologie, Laboratoire de Bactériologie Clinique, Clermont Ferrand, France
J Antimicrob Chemother 66:1052-6. 2011We investigated the bacteriostatic and bactericidal activities of piperacillin/tazobactam against 16 clinical Escherichia coli producing inhibitor-resistant TEM β-lactamases (IRT; 13/16) and complex mutant TEM enzymes (CMT; 3/16).
- Sequential intravenous/oral moxifloxacin versus intravenous piperacillin-tazobactam followed by oral amoxicillin-clavulanate for the treatment of complicated skin and skin structure infectionPhilip Giordano
Orlando Regional Medical Center ORMC, Orlando, FL, USA
Int J Antimicrob Agents 26:357-65. 2005..v.)/oral (p.o.) moxifloxacin (400 mg once a day) or a control regimen of i.v. piperacillin-tazobactam (3.0/0.375 g every 6 h) followed by p.o...
- False positive galactomannan Platelia due to piperacillin-tazobactamM P Gerlinger
Unite de Parasitologie, Service de Biologie, Hopital Andre Mignot, Le Chesnay, France
Med Mal Infect 42:10-4. 2012..But galactomannan detection may be falsely positive, and this false positivity has been associated with piperacillin-tazobactam treatment, the main antibiotic combination used in clinical hematology.
- Thrombocytosis under ciprofloxacin and tazobactam/piperacillinJosef Finsterer
Neurological Department, Krankenanstalt Rudolfstiftung, Vienna, Austria
Platelets 14:329-31. 2003Whether the simultaneous administration of ciprofloxacin or tazobactam/piperacillin increases the risk of thrombocytosis is unknown...
- Piperacillin/tazobactam-induced seizure rapidly reversed by high flux hemodialysis in a patient on peritoneal dialysisChin Sheng Lin
Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R O C
Am J Med Sci 333:181-4. 2007Despite popular use of piperacillin, the dire neurotoxicity associated with piperacillin still goes unrecognized, leading to a delay in appropriate management...
- Inhibition of flucloxacillin tubular renal secretion by piperacillinCornelia B Landersdorfer
IBMP Institute for Biomedical and Pharmaceutical Research, Nürnberg Heroldsberg, Germany
Br J Clin Pharmacol 66:648-59. 2008To explore the extent, time course, site(s), mechanism and possible clinical relevance of the pharmacokinetic (PK) interaction between piperacillin and flucloxacillin.
- Proteomic analysis of Escherichia coli with experimentally induced resistance to piperacillin/tazobactamKênia Valéria dos Santos
Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Caixa Postal 486, 30 161 970 Belo Horizonte MG, Brazil
Res Microbiol 161:268-75. 2010..The aim of the present study was to identify changes in the subproteome of a laboratory-derived piperacillin/tazobactam-resistant strain of Escherichia coli (minimal inhibitory concentration [MIC] = 128 mg/L) as compared ..
- Anaphylaxis to piperacillin-tazobactam despite a negative penicillin skin testM A Rank
Allergy 62:964-5. 2007
- Piperacillin-tazobactam-induced drug hypersensitivity syndromeSimone Fahim
Division of Dermatology, Department of Medicine, University of Ottawa, Ontario, Canada
Cutis 77:353-7. 2006..The syndrome is a triad of fever, skin eruption, and internal organ involvement. Prompt identification and discontinuation of the offending drug with symptomatic treatment of toxic effects is the mainstay of therapy for DHS...
- Comparative study of the effects of ceftizoxime, piperacillin, and piperacillin-tazobactam concentrations on antibacterial activity and selection of antibiotic-resistant mutants of Enterobacter cloacae and Bacteroides fragilis in vitro and in vivo in mixeLorna E T Stearne
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Antimicrob Agents Chemother 48:1688-98. 2004The effects of ceftizoxime (CZX), piperacillin (PIP), and PIP-tazobactam (PT) concentrations on the antibacterial activity and selection of resistant mutants of Bacteroides fragilis and Enterobacter cloacae were investigated in vitro in a ..
- Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneumMichael Bette
Institute of Anatomy and Cell Biology, Philipps University of Marburg, Marburg 35033, Germany
Shock 25:23-9. 2006..We evaluated the prophylactic effect of O3/O2-PP combined with tazobactam/piperacillin (TZP) in polymicrobial lethal peritonitis...
- Differences in the changes in resistance patterns to third- and fourth-generation cephalosporins and piperacillin/tazobactam among Klebsiella pneumoniae and Escherichia coli clinical isolates following a restriction policy in a Greek tertiary care hospitaGeorge Petrikkos
First Department of Propaedeutic Medicine, Infectious Diseases Laboratory, G K Daikos, Laikon General Hospital, Aghiou Thoma 17, Goudi, Athens 11527, Greece
Int J Antimicrob Agents 29:34-8. 2007The aim of the present study was to investigate whether replacement of broad-spectrum cephalosporins (CEPs) by piperacillin/tazobactam (TZP) as first-line empirical therapy may have an effect on beta-lactam resistance among Klebsiella ..
- Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters: evaluation of the sieving coefficientA Arzuaga
Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Vitoria Gasteiz, Spain
Blood Purif 24:347-54. 2006b>Piperacillin-tazobactam is commonly used to treat infections in ICU patients. Controversial data have been published about the sieving/saturation coefficient (Sc/Sa) of piperacillin during continuous renal replacement therapies (CRRT)...
- Antibiotic policy and prescribing strategies for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae: the role of piperacillin-tazobactamL R Peterson
Department of Pathology and Laboratory Medicine, Division of Clinical Microbiology, and Department of Medicine, Division of Infectious Diseases, Evanston Northwestern Healthcare and Northwestern University, Evanston, IL 60201, USA
Clin Microbiol Infect 14:181-4. 2008..monobactam antimicrobials, but as susceptible to beta-lactam-beta-lactamase inhibitor combinations, including piperacillin-tazobactam, when they test as such...
- Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infectionsGita Wasan Patel
Medical Center of Plano, TX 75075, USA
Diagn Microbiol Infect Dis 64:236-40. 2009This comparison of intermittent versus extended-infusion piperacillin-tazobactam among patients with Gram-negative infections revealed similar mortality and length of stay. Outcomes remained similar when stratified by MIC value.
- Acute generalized exanthematous pustulosis caused by piperacillin/tazobactamTeresa Grieco
J Am Acad Dermatol 52:732-3. 2005
- Ciprofloxacin plus piperacillin compared with tobramycin plus piperacillin as empirical therapy in febrile neutropenic patients. A randomized, double-blind trialJames E Peacock
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1042, USA
Ann Intern Med 137:77-87. 2002..Therapy with an aminoglycoside and a beta-lactam remains common empirical therapy for febrile neutropenic patients. Concerns of aminoglycoside-induced ototoxicity and nephrotoxicity have led to studies of alternate regimens...
- Antipseudomonal activity of piperacillin/tazobactam: more than a decade of experience from the SENTRY Antimicrobial Surveillance Program (1997-2007)Ronald N Jones
JMI Laboratories North Liberty, IA 52317, USA
Diagn Microbiol Infect Dis 65:331-4. 2009We evaluated the susceptibility rates for piperacillin/tazobactam tested against Pseudomonas aeruginosa isolates from the Asia-Pacific (APAC), Europe (EU), Latin America (LA), and North America (NA) for 1997 to 2007...
- Delayed hypersensitivity to piperacillinA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit C I Columbus Rome, Italy
Allergy 57:459. 2002
- Piperacillin-induced immune hemolysis: new cases and a concise review of the literatureBeate Mayer
Institute for Transfusion Medicine, Charite University Medicine, Berlin, Germany
Transfusion 50:1135-8. 2010In this study, the data of eight new patients in conjunction with previously reported cases with piperacillin-induced immune hemolytic anemia (PIHA) are described.
- Haemolytic anaemia caused by piperacillin-tazobactamI Dapper
Intensive Care Unit, AZ Monica, Antwerpen, Belgium
Acta Clin Belg 64:517-9. 2009We report a case of haemolytic due to the use of piperacillin-tazobactam in a 50-year-old woman. Since 2002 4 other cases were reported. Either the presence of piperacillin as tazobactam can induce haemolysis...
- Piperacillin/tazobactam versus cefepime as initial empirical antimicrobial therapy in febrile neutropenic patients: a prospective randomized pilot studyA Bohme
Department of Hematology Oncology, Johann Wolfgang Goethe University Frankfurt Germany
Eur J Med Res 3:324-30. 1998..presented prospective, randomized study was to compare the efficacy of empirical antimicrobial monotherapy with piperacillin/tazobactam (PIP/TAZ) to cefepime (CEFP) for treatment of infections in neutropenic patients...
- Cefepime plus amikacin versus piperacillin-tazobactam plus amikacin for initial antibiotic therapy in haematology patients with febrile neutropenia: results of an open, randomized, multicentre trialMiguel A Sanz
Servicio de Hematologia, Hospital Universitario La Fe, Av Campanar 21, 46009 Valencia, Spain
J Antimicrob Chemother 50:79-88. 2002..The aim of this study is to evaluate the efficacy and safety of cefepime plus amikacin compared with piperacillin-tazobactam plus amikacin for initial empirical treatment of fever in adult haematology patients with severe ..
- Immune-mediated severe hemolytic crisis with a hemoglobin level of 1.6 g/dl caused by anti-piperacillin antibodies in a patient with cystic fibrosisS Kunzmann
University Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Infection 38:131-4. 2010..6 g/dl after 7 days of treatment with piperacillin, consistent with an immune-mediated hemolytic crisis...
- Pharmacokinetics of piperacillin and tazobactam in critically ill patients with renal failure, treated with continuous veno-venous hemofiltration (CVVH)T S van der Werf
Department of Internal Medicine, University Hospital Groningen, The Netherlands
Intensive Care Med 23:873-7. 1997Kinetics of piperacillin (pip), in combination with the beta-lactamase inhibitor tazobactam (taz) have been studied in volunteers and patients in relatively stable conditions...
- Elimination of the piperacillin/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failureM Valtonen
Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland
J Antimicrob Chemother 48:881-5. 2001The elimination of the piperacillin/tazobactam combination was studied in six patients with acute renal failure undergoing either continuous venovenous haemofiltration (CVVH) or continuous venovenous haemodiafiltration (CVVHDF) at 1 L/h ..
- Delayed hypersensitivity to acylureidopenicillins: a case reportF Gaeta
Unità di Allergologia, Complesso Integrato Columbus, Via G Moscati, 3100168 Rome, Italy
Allergy 63:787-9. 2008
- Clinical efficacy and pharmacoeconomics of a continuous-infusion piperacillin-tazobactam program in a large community teaching hospitalEdward M Grant
Ortho McNeil Pharmaceutical, Inc, Raritan, New Jersey, USA
Pharmacotherapy 22:471-83. 2002To compare continuous versus intermittent administration of piperacillin-tazobactam with regard to clinical, microbiologic, and economic outcomes.
- Pharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysisSilke C Mueller
Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Rostock, D 18057 Rostock, Germany
Antimicrob Agents Chemother 46:1557-60. 2002The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination half-life of piperacillin was 4.3 +/- 1...
- Efficacy and safety of ertapenem versus piperacillin-tazobactam for the treatment of intra-abdominal infections requiring surgical interventionArturo S Dela Pena
Philippine General Hospital, Manila, Philippines
J Gastrointest Surg 10:567-74. 2006..The aim of this study was to demonstrate that ertapenem was not inferior to piperacillin-tazobactam for the treatment of community-acquired intra-abdominal infections...
- Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment--a retrospective analysis in 38 children with cystic fibrosisP Reichardt
Children s University Hospital, University of Leipzig, Germany
Infection 27:355-6. 1999..Recently it was suggested that piperacillin/tazobactam (PT) also may cause bone marrow toxicity. We retrospectively analyzed 100 i.v...
- A multicenter, double-blind, placebo-controlled trial comparing piperacillin-tazobactam with and without amikacin as empiric therapy for febrile neutropeniaA Del Favero
Istituto Medicina Interna e Scienze Oncologiche, Universita di Perugia, Perugia, Italy
Clin Infect Dis 33:1295-301. 2001In a prospective, multicenter, double-blind, randomized clinical trial, we compared the efficacy of piperacillin-tazobactam (4.5 g 3 times daily intravenously) plus placebo versus piperacillin-tazobactam plus amikacin (7...
- Electrolytes imbalance: a rare side effect of piperacillin/ tazobactam therapyShakir Hussain
Department of Trauma and Orthopaedics, The University Hospital Birmingham NHS Foundation Trust, United Kingdom
J Coll Physicians Surg Pak 20:419-20. 2010..We report a case of severe hypokalemia secondary to piperacillin/tazobactam in a patient with normal renal function and normal serum potassium level who had presented with a ..
- Prospective comparative study of cefotetan with piperacillin for prophylaxis against infection in elective colorectal surgeryM J Hershman
Department of Surgery, Hammersmith Hospital, London, UK
J R Coll Surg Edinb 35:29-32. 1990This study compared one dose of cefotetan with three doses of piperacillin as prophylaxis against wound infection in 153 patients undergoing elective colorectal surgery...
- Randomized, multicenter, double-blind study of efficacy, safety, and tolerability of intravenous ertapenem versus piperacillin/tazobactam in treatment of complicated intra-abdominal infections in hospitalized adultsNicholas Namias
Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
Surg Infect (Larchmt) 8:15-28. 2007Complicated intra-abdominal infections are a common problem in surgical practice. This study compared the effectiveness of ertapenem (1 g qd) and piperacillin/tazobactam (3.375 g q6h) in the treatment of these infections.
- Antimicrobial prophylaxis for transrectal prostatic biopsy: a prospective study of ciprofloxacin vs piperacillin/tazobactamL Cormio
Department of Urology, Di Venere Hospital, Bari Carbonara, Italy
BJU Int 90:700-2. 2002To compare the efficacy of short-term parenteral prophylaxis with piperacillin/tazobactam (P/T) with long-term oral prophylaxis with ciprofloxacin in preventing infective complications after transrectal prostatic biopsy (TPB).
- Acquisition of resistant bowel flora during a double-blind randomized clinical trial of ertapenem versus piperacillin-tazobactam therapy for intraabdominal infectionsMark J DiNubile
Merck Research Laboratories, P O Box 4, BL3 4, West Point, PA 19486, USA
Antimicrob Agents Chemother 49:3217-21. 2005..clinical trial, adults with complicated intraabdominal infection requiring surgery were randomized to receive piperacillin-tazobactam (3.375 g every 6 h) or ertapenem (1 g once a day) for 4 to 14 days...
- Activity of piperacillin/tazobactam in combination with amikacin, ciprofloxacin, and trovafloxacin against Pseudomonas aeruginosa by time-killD S Burgess
College of Pharmacy, The University of Texas at Austin, Austin, Texas, 78712, USA
Diagn Microbiol Infect Dis 38:37-41. 2000..We compared the activity of piperacillin/tazobactam in combination with amikacin, ciprofloxacin, or trovafloxacin at different concentrations against P...
- Piperacillin/tazobactam vs imipenem/cilastatin in the treatment of nosocomial pneumonia--a double blind prospective multicentre studyD V Schmitt
Universitatsklinikum, Herzzentrum Leipzig, Herzchirurgie, Russenstrasse 19, 04289 Leipzig, Germany
Infection 34:127-34. 2006b>Piperacillin/tazobactam (P/T) with its broad spectrum of antibacterial activity is used widely for the treatment of moderate to severe polymicrobial nosocomial infections.
- Outcomes of bacteremia due to Pseudomonas aeruginosa with reduced susceptibility to piperacillin-tazobactam: implications on the appropriateness of the resistance breakpointVincent H Tam
University of Houston College of Pharmacy, Houston, Texas 77030, USA
Clin Infect Dis 46:862-7. 2008..Recent studies have emphasized the importance of appropriate empirical therapy, but controversy arises when piperacillin-tazobactam is used against isolates with reduced susceptibility.
- Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for treatment of nosocomial pneumoniaManjari Joshi
University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD 21201, USA
Respir Med 100:1554-65. 2006This randomized, double-blind, multicenter study compared the efficacy and safety of piperacillin/tazobactam (P/T) and imipenem/cilastatin (IMP), both in combination with an aminoglycoside, in hospitalized patients with acute nosocomial ..
- High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniaeL B Rice
Medical Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 44:362-7. 2000We describe Klebsiella pneumoniae 15571, a clinical isolate resistant to ceftazidime MIC = 32 microg/ml) and piperacillin-tazobactam (MICs = 1,024 and 128 microg/ml). K. pneumoniae 15571 expresses a single beta-lactamase with a pI of 7.6...
- In vitro activity of piperacillin/tazobactam versus other broad-spectrum antibiotics against nosocomial gram-negative pathogens isolated from burn patientsE Mokaddas
Department of Microbiology, Ibn Sina Hospital, Kuwait
J Chemother 10:208-14. 1998..Tazobactam, a potent inhibitor of beta-lactamases, extends the spectrum of piperacillin to include many beta-lactamase producing bacteria...
- Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patientsKatherine M Shea
Infectious Diseases, Seton Family of Hospitals, University Medical Center at Brackenridge, Austin, TX, USA
Ann Pharmacother 43:1747-54. 2009..Prolonging the infusion of a beta-lactam antibiotic enhances the time in which unbound drug concentrations remain above the minimum inhibitory concentration (fT>MIC)...
- Controlled trials of double beta-lactam therapy with cefoperazone plus piperacillin in febrile granulocytopenic patientsD J Winston
Department of Medicine, University of California, Los Angeles 90024
Am J Med 85:21-30. 1988The efficacy and safety of double beta-lactam therapy with cefoperazone plus piperacillin in febrile granulocytopenic patients were compared with moxalactam plus piperacillin, ceftazidime plus piperacillin, and imipenem alone in two ..
- Treatment of polymicrobial infections: post hoc analysis of three trials comparing ertapenem and piperacillin-tazobactamJoseph Solomkin
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
J Antimicrob Chemother 53:ii51-7. 2004..complicated intra-abdominal, complicated skin/skin-structure and acute pelvic infections was compared with piperacillin-tazobactam 3.375 g every 6 h in a post hoc analysis of data from three large randomized double-blind trials...
- Antimicrobial activity of isepamicin (SCH21420, 1-N-HAPA gentamicin B) combinations with cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, imipenem, mezlocillin and piperacillin tested against gentamicin-resistant and susceptible gram-negative bacilli R N Jones
Department of Pathology, University of Iowa College of Medicine, Iowa City
J Chemother 3:289-94. 1991..The rank order of synergy (complete or partial) was; cefotaxime = ceftazidime = ceftriaxone = mezlocillin = piperacillin (75% to 80%) greater than imipenem (66%) greater than ciprofloxacin (38%)...
- Bacteremia due to extended-spectrum beta -lactamase-producing Escherichia coli in the CTX-M era: a new clinical challengeJesús Rodríguez-Baño
Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Sevilla, 41071, Spain
Clin Infect Dis 43:1407-14. 2006..Bacteremia caused by these organisms represents a clinical challenge, because the organisms are frequently resistant to the antimicrobials recommended for treatment of patients with suspected E. coli sepsis...
- [A multicenter clinical trial of piperacillin/tazobactam in burn infection]Weishi Xu
Burn Institute, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, P R China
Zhonghua Shao Shang Za Zhi 18:75-7. 2002To evaluate the efficacy of piperacillin/tazobactam in the management of burn infection.
- In vitro synergy testing of levofloxacin, ofloxacin, and ciprofloxacin in combination with aztreonam, ceftazidime, or piperacillin against Pseudomonas aeruginosaSusan L Pendland
The University of Illinois at Chicago, Department of Pharmacy Practice, Microbiology Research Laboratory, Chicago, IL, USA
Diagn Microbiol Infect Dis 42:75-8. 2002The synergistic potential of levofloxacin, ofloxacin and ciprofloxacin combined with aztreonam, ceftazidime, or piperacillin was compared using 24 strains of Pseudomonas aeruginosa with varying susceptibility profiles...
- Efficacy and safety of doripenem versus piperacillin/tazobactam in nosocomial pneumonia: a randomized, open-label, multicenter studyAlvaro Rea-Neto
Hospital de Clinicas da Universidade Federal do Parana, Rua General Carneiro, Curitiba, Brasil
Curr Med Res Opin 24:2113-26. 2008..This prospective, randomized, open-label, multicenter study was designed to establish whether doripenem was noninferior to piperacillin/tazobactam in NP.
- Comparative costs of ertapenem and piperacillin-tazobactam in the treatment of diabetic foot infectionsAlan D Tice
John A Burns School of Medicine, University of Hawaii, Honolulu, USA
Am J Health Syst Pharm 64:1080-6. 2007To evaluate potential cost savings, trial data were used to determine the clinical outcomes for i.v. ertapenem given once daily and i.v. piperacillin-tazobactam given every six hours daily in treating diabetic foot infections.
- Ertapenem once a day versus piperacillin-tazobactam every 6 hours for treatment of acute pelvic infections: a prospective, multicenter, randomized, double-blind studySubir Roy
Keck School of Medicine at USC, Los Angeles, CA, USA
Infect Dis Obstet Gynecol 11:27-37. 2003To compare ertapenem therapy with piperacillin-tazobactam therapy for the management of acute pelvic infections.
- False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactamAnnie Sulahian
N Engl J Med 349:2366-7. 2003
- General microbiology and in vitro susceptibility of anaerobes isolated from complicated skin and skin-structure infections in patients enrolled in a comparative trial of ertapenem versus piperacillin-tazobactamEllie J C Goldstein
R M Alden Research Laboratory, Santa Monica, CA, 90404, USA
Clin Infect Dis 35:S119-25. 2002In a recently completed study of once-a-day ertapenem versus piperacillin-tazobactam every 6 h in the treatment of complicated skin and skin-structure infections, 540 patients were randomized in a 1rcolon;1 ratio and assigned to 1 of 2 ..
Research Grants52
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS--MECHANISMSKIM BROUWER; Fiscal Year: 2000....
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2004..The merit of this work is realized when one considers the number of xenobiotics that undergo hepatic elimination, and the potential for alterations in hepatic transport of these agents. ..
- Pharmacokinetics and Pharmacodynamics of Antibiotics in Premature InfantsMichael Cohen Wolkowiez; Fiscal Year: 2010..b>Piperacillin/tazobactam and metronidazole are two antimicrobials commonly used in the nursery for which few pharmacokinetic ..
- Ampicillin resistance mechanisms in E. faeciumLouis Rice; Fiscal Year: 2006..abstract_text> ..
- Ampicillin resistance mechanisms in E. faeciumLouis Rice; Fiscal Year: 2005..abstract_text> ..
- Ampicillin resistance mechanisms in E. faeciumLouis Rice; Fiscal Year: 2008..abstract_text> ..
- REGULATION OF AMPICILLIN RESISTANCE IN E FACEIUMLouis Rice; Fiscal Year: 2002..They will also yield important new information on mechanisms of cell wall synthesis in E. faecium and other Gram-positive bacteria as well as on the mechanisms by which ampicillin resistance in E. faecium is regulated. ..
- Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faeciumLouis B Rice; Fiscal Year: 2010..This project aims to identify and characterize the complex and redundant mechanisms of ?-lactam resistance in an effort to better understand enterococcal physiology and promote identification of novel therapeutic targets. ..
- REGULATION OF AMPICILLIN RESISTANCE IN E FACEIUMLouis Rice; Fiscal Year: 2001..They will also yield important new information on mechanisms of cell wall synthesis in E. faecium and other Gram-positive bacteria as well as on the mechanisms by which ampicillin resistance in E. faecium is regulated. ..
- Ampicillin resistance mechanisms in E. faeciumLouis Rice; Fiscal Year: 2007..abstract_text> ..
- REGULATION OF AMPICILLIN RESISTANCE IN E FACEIUMLouis Rice; Fiscal Year: 2004..They will also yield important new information on mechanisms of cell wall synthesis in E. faecium and other Gram-positive bacteria as well as on the mechanisms by which ampicillin resistance in E. faecium is regulated. ..
- REGULATION OF AMPICILLIN RESISTANCE IN E FACEIUMLouis Rice; Fiscal Year: 2003..They will also yield important new information on mechanisms of cell wall synthesis in E. faecium and other Gram-positive bacteria as well as on the mechanisms by which ampicillin resistance in E. faecium is regulated. ..
- Novel Targets for Treatment of Pseudomonas aeruginosaPhilip Lister; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- HOST RESPONSE TO TRAUMA RESEARCH TRAINING PROGRAMJoseph Solomkin; Fiscal Year: 2007..D. or D.Sc.). We have demonstrated that the trainees participating in this program have a high likelihood of success in becoming university-based researchers. ..
- New Nosocomial Interventions to Decrease Antimicrobial Resistance TransmissionAnthony Harris; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Therapy for Liver Cancer by Targeting Energy MetabolismJean Francois Geschwind; Fiscal Year: 2007..This translational study combining the use of radiological and basic science research tools is both necessary and fundamental to firmly lay the groundwork for clinical trials. ..
- Epidemiology of imipenem-resistant P.aeruginosaAnthony Harris; Fiscal Year: 2007..unreadable] Aim 4: Determine the cost-effectiveness of three different infection control interventions. [unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- New Nosocomial Interventions to Decrease Antimicrobial Resistance TransmissionAnthony Harris; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2010..An important goal is to develop tools to predict and assess altered drug transport in humans. Results of these studies will impact drug development, improve outcomes of drug therapy, and help prevent drug-induced liver injury. ..
- Epidemiology of emerging pathogens among hospitalizeds patientsAnthony D Harris; Fiscal Year: 2010..The reasons for the emergence of A. baumannii are unknown and no interventions have been successful at curbing this emergence. For these reasons, A. baumannii is a significant public health problem. ..
- The Role of TGF-beta in the pathogenesis of Experimental Biliary AtresiaEvan Nadler; Fiscal Year: 2008..This proposal is designed to help determine which mediators are important in the development of the liver failure associated with biliary atresia, and whether blocking these mediators may be useful in preventing liver failure. ..
- New Nosocomial Interventions to Decrease Antimicrobial Resistance TransmissionAnthony Harris; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2007..abstract_text> ..
- Novel Targets for Treatment of Pseudomonas aeruginosaPhilip Lister; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Epidemiology of imipenem-resistant P.aeruginosaAnthony Harris; Fiscal Year: 2008..unreadable] Aim 4: Determine the cost-effectiveness of three different infection control interventions. [unreadable] [unreadable] [unreadable]..
- HOST RESPONSE TO TRAUMA RESEARCH TRAINING PROGRAMALEX LENTSCH; Fiscal Year: 2008..We have added junior researchers in these groups who have recently obtained NIH funding, and have organized a leadership transition plan for this program. ..
- Therapy for Liver Cancer by Targeting Energy MetabolismJean Francois Geschwind; Fiscal Year: 2006..This translational study combining the use of radiological and basic science research tools is both necessary and fundamental to firmly lay the groundwork for clinical trials. ..
- REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMAJoseph Solomkin; Fiscal Year: 2003..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2003..The merit of this work is realized when one considers the number of xenobiotics that undergo hepatic elimination, and the potential for alterations in hepatic transport of these agents. ..
- REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMAJoseph Solomkin; Fiscal Year: 2002..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2002..The merit of this work is realized when one considers the number of xenobiotics that undergo hepatic elimination, and the potential for alterations in hepatic transport of these agents. ..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2001..The merit of this work is realized when one considers the number of xenobiotics that undergo hepatic elimination, and the potential for alterations in hepatic transport of these agents. ..
- REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMAJoseph Solomkin; Fiscal Year: 2001..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS--MECHANISMSKIM BROUWER; Fiscal Year: 1999....
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2002..The merit of this work is realized when one considers the number of xenobiotics that undergo hepatic elimination, and the potential for alterations in hepatic transport of these agents. ..
- Regulation of Cellular division in M. tuberculosisRICHARD SLAYDEN; Fiscal Year: 2003..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..
- Regulation of Cellular division in M. tuberculosisRICHARD SLAYDEN; Fiscal Year: 2004..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..
- Epidemiology of imipenem-resistant P.aeruginosaAnthony Harris; Fiscal Year: 2006..unreadable] Aim 4: Determine the cost-effectiveness of three different infection control interventions. [unreadable] [unreadable] [unreadable]..
- Regulation of Cellular division in M. tuberculosisRICHARD SLAYDEN; Fiscal Year: 2006..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. [unreadable] [unreadable] [unreadable]..
- ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS-MECHANISMSKIM BROUWER; Fiscal Year: 2005....
- DEVELOPMENT OF A MODEL TO PREDICT DRUG HEPATOTOXICITYKIM BROUWER; Fiscal Year: 2005..g., dog, monkey) as well as from humans is a particularly attractive feature of this novel in vitro model, and will be developed during the scale-up phase of this model system in a subsequent R33 application. ..
- Epidemiology of imipenem-resistant P.aeruginosaAnthony Harris; Fiscal Year: 2005..Aim 4: Determine the cost-effectiveness of three different infection control interventions. ..
- Study design importance in analyzing emerging pathogensAnthony Harris; Fiscal Year: 2005..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
- Regulation of Cellular division in M. tuberculosisRICHARD SLAYDEN; Fiscal Year: 2005..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..
- REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMAJoseph Solomkin; Fiscal Year: 2004..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..


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A Sweet Answer to Battery Power
Organic battery created from local Malaysian ingredients
Did you know brown sugar and leaves can produce electricity? A Malaysian Intel International Science and Engineering Fair1 (Intel ISEF) finalist combined these locally sourced ingredients to create an organic battery.
Organic battery
The inspiration for 17-year-old Mohammad Dzarul Dol Malek's Intel ISEF project came from an unusual source: a cow—or rather, what the cow produced—on his grandfather's sugarcane farm in Malaysia.
Inspiration for battery of the future
Because the farm is located far from electrical sources, Dzarul decided to try to create an "organic" battery using inexpensive, locally sourced materials. "When I first thought about the organic battery, I thought I should use cow dung," he said. But his father encouraged him to consider what happens in a cow's stomach—where enzymes break down leaves to create energy.
Dzarul replicated the cow enzyme using brown sugar, a resource that is plentiful on the family farm, and began using it to break down different types of leaves. The resulting solutions fermented and ultimately produced electricity. Of the leaves he tested, the plant that produced the highest voltage was Chromolaena odorata, an invasive plant also available in abundance on the farm.
From Malaysia to Los Angeles
Dzarul traveled close to 9,000 miles from Kuala Lumpur to Los Angeles to showcase his organic battery at the 2011 Intel ISEF competition. Though his Intel ISEF research did not immediately yield a battery viable for production, he set a goal to continue developing the idea. Now studying science and engineering in college in Malaysia, he hopes to someday patent an eco-friendly, locally sourced organic battery to replace conventional dry cell batteries that pollute the waste stream with mercury and other toxic materials. "When I saw the other students' projects at ISEF, it really inspired me," he says. "It made me want to do bigger and better things."
2011 Intel ISEF
Traveling to Los Angeles as a finalist in the 2011 Intel ISEF further inspired Dzarul to continue his battery research in college.
Intel competitions
Intel supports and encourages young scientists, engineers, and entrepreneurs with world-class science, math, and technology competitions.
Intel education
Intel is helping to transform the lives of millions worldwide through education, technology, and programs that challenge and inspire.
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subset: commoncrawl


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Bellowhead Melkweg Tickets
Want to see Bellowhead at Melkweg? Experience the exhilaration of Bellowhead at Melkweg in 2015. Don't miss the opportunity to get your Bellowhead tickets at Melkweg. Select a date to view the range of Bellowhead tickets available. Buy your Bellowhead Melkweg tickets here!
You might have been looking for one of our bestsellers below:


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In today's world, people want to be healthy, they want to be happy, but instead they are getting stressed out , depressed, getting less sleep, more negative thoughts and feeling isolated.
Laughter Yoga is a unique concept where any one can laugh as a form of exercise in a group. Which soon turns into real & spontaneous laughter. Find out more about benefits of Laughter Yoga on your body & mind.
I was suffering with severe Parkinson's which made me feel helpless and dependent. But, a year ago, I joined the laughter club and since then my condition improved by almost 50 per cent. I used to go through...
Meet new people and practice laughter yoga togetherFind a club
Become a Certified Laughter Yoga Leader, Teacher & MasterClick Here
Keep Up-To-Date with Latest News around the worldClick Here
What Laughter Yoga can do for You and Your BusinessFind Out More
Read articles on Laughter Yoga activities around the world.Discover More
Training DVD's, CD's, Books and audio-video downloadsClick Here
Continued Education for Laughter Yoga ProfessionalsDiscover More
Find out more about worldwide Laughter Yoga eventsSee Events


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Kingdom- Bank Head ft. Kelela
Posted by Ben Friedlander
"Bank Head" originally debuted back in January as one of the stand out tracks from the Night Slugs All Stars Volume 2 compilation. Now, Night Slugs soldier and Fade to Mind general Kingdom is re-releasing a vocal version of the track alongside F2M singer Kelela as part of Vertical XL, his first official release for his own label. The EP is due out on May 28th, while the vocal version of "Bank Head" will also appear on a forthcoming mixtape from Kelela. Keep your ears peeled for more work from this girl. We saw her perform a bunch of her unreleased material at SXSW this year and she blew us away.
No. 1


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Rohit Bharadwaj, who was last in Star Plus' Navya is all set to be back on screen with a bang in the role of Yudhisthir in Siddharth Kumar Tiwary's upcoming mythological show Mahabharat. Rohit has prepared himself well to get involved in the character of Yudhishthir. TellyBuzz here unveils the first look picture of Rohit as Yudhishthir in Mahabharat.
Talking about the preparations he has done to play this character perfectly, he told us, "I started off with the basic step and that too reading books not only related to Mahabharat but also about the people who talk about dharma as Yudhishthir is known as Dharmaraj. I have also watched few scenes of the older version of Mahabharat."
When asked about his costumes in the show, whether he is comfortable wearing costumes or not, he laughed and said, "No one feels comfortable with their costumes here but the costume is very beautiful and gracious. As an actor, its feeling wonderful to be a part of the show and wearing heavy costumes, jewellery and Mukut. It's looking grand visually but it's very difficult to wear all these things and perform but we have forgotten about the difficulties because the kind of show it is."
Rohit shared about the bonding with his co-actors on the sets, "My earlier co-actor Shaheer Sheikh, whom I love a lot is here on this show. We are sharing the same room and he calls me Bhai and I call him Chote. I am enjoying with him. We meet and make new friends at a new place but nayi jagah par purana dost mil jaye toh thoda easy ho jata hai (Chuckles)."
He is very excited about the launch of the mythological show Mahabharat, "I am feeling very excited about the launch of this show. Initially,
I didn't realize that how huge this show is going to be but I have now realized
that this show is going to be very big. People are going to love the show. If they don't
like the content, they will like the accessories like jewellery, if they don't like the
jewellery they will like the acting and if they don't like the acting, they
will love the visuals," concludes Rohit.
Anwesha Kamal
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Dear Readers,
Rohit love ur chemistry with Shaheer both on screen & off screen. Love dis intw...Nyc answer by u Rohit..U r doing gr8 job as Yudhistir.
10 more days to go! So the countdown begins... :)
Rohit bhardwaj ur rockstar man...luv ur role in Navya n many many heartiest congrats for winning the best actor award...eager to watch you as yudhishtir in mahabharata...m sure u vil rock this time as welll...all the best
waiting to see shaheer sheikh as arjun in mahabharat
god bless u both waiting to see shaheer sheikh as arjun in mahabharat
Edited on:06 September 2013 at 1:54am
Congrats rohit...i m sure u will rock in this role too...
Rohit u r a rockstar man...great wrk done in navya..congrats Fr ur best actor award in waapsi...u deserve man...eagarly waiting Fr this role
Lookng amazing as usual...desperately waiting to c u as yudhister...u rock :-) <3
God bless u both! :)) Eagerly waiting for Yudhishthir and Arjun's arrival on television.
u rock dude...heartiest congratulations for the work u have done in the film Waapsi and won best actor award!!!! And best of for this new role of Yudhishthir.God bless you...
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Web posted and Copyright © October 1, 1998, American Bankruptcy Institute.
§103. Any party in interest would be allowed to challenge any debtor's eligibility based on ability to repay.
Any party in interest would be allowed to move for such dismissal or conversion, unless the debtor's income was
below a specified level. Where the debtor's household is four or less, the threshold would be the national median for
a household of the same size. Where the debtor's household is larger than four, the threshold would be the national
median for a household of four, increased by $583 for each member of the debtor's household beyond four.
§508. All debts covered by §523(a)(1) (certain tax obligations) would be non-dischargeable in chapter 13 as well as
in chapter 7.
No change is made in current law, under which §523(a)(1) applies only in chapter 7 cases.
§117. Congress would express its sense that states should develop course in personal finance for grade school and
high school students.
§129. All bifurcation of secured claims would be based on the debtor's cost of replacement, without deduction for
costs of sale. For household and personal goods, this would be retail price.


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STAVANGER -- Wintershall, the largest internationally active German crude oil and natural gas producer, announces an oil discovery in the southern part of the Norwegian North Sea about 200 km off the coast of Stavanger. The own-operated Asha Noor appraisal wells 16/1-16 and its delineation 16/1-16 A in production licence PL 457 were drilled about 3 km east of the 16/1-9 discovery well in the Ivar Aasen discovery and about 3 km north of the Edvard Grieg field.
Preliminary resource estimates range between 20 and 40 MMboe. Extensive coring, sampling and data acquisition have been carried out. The results will now be evaluated to further determine resources and the commerciality of the discovery.
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Posted by Nicole
I'm finally done with the semester! Such sweet relief.
My morning started at 6 AM, which gave me plenty of time to shower, eat breakfast, and calmly walk to campus.
Not gonna lie, I always feel productive when I wake up to a sunrise!
Then, I did a few last minute practice problems and took my test. All the build-up definitely made turning in the exam even better.
I was extra excited to finish my final because the rest of the day was filled with fun plans.
1- Post-final Starbucks trip. Deserved it!!!
2- Our dance team recently got a makeup sponsor and today we got all the goods to make us beautiful. New mascara, eyeshadows, lipstick, skin care products, and bronzer. Also, we each got a consultation and complimentary concealer/powder and blush specific to our skin tones. It was like an early Christmas!
3- Soraya, one of the dance captains, and I went to the mall afterwards so she could pick up a Secret Santa gift for tonight. I love the view from the Beverly Center – the Hollywood sign and Downtown LA skyline all in one place.
4- After a late lunch, I headed to the gym to half-ass a workout. 4 miles of incline walking (6%) while reading blogs did the trick. It felt good to move.
5- Now it's time for me to get dolled up for our dance team dinner, gift exchange, and Christmas party! Dressing up is always so fun and it feels like forever since I put on a fancy dress and heels. I'm actually bringing my real camera out tonight instead of just my iPhone, so the next post will surely be filled with some good photos. Woo!
Hope your week is going well… 6 days till Christmas!
Question: Since this was a kinda girly post- What is your favorite makeup brand and/or product?
Some of my favorites:
- Benefit Coralista blush and Hoola bronzer – these come especially in handy during the paler winter months
- Mac eyeshadows are great too – I used to collect them!
- Maybelline Ultra Liner liquid eyeliner – affordable and it lasts a long time!
- Urban Decay eyeshadow palettes – good for travel because they have a bit of everything
5 Responses to Makeup Madness
MALL MADNESS!! (ok, now I'll actually read this post.)
Jordan @ food, sweat, and beers recently posted..Bacon, Bacon Everywhere (And not a drop to drink)
Chanel is my favorite, though I only receive it as gifts. As I'm a grad student and am currently SPONSORLESS!! Brutal, but true.
Jordan @ food, sweat, and beers recently posted..Bacon, Bacon Everywhere (And not a drop to drink)
Melissa Johannesen says:
SO glad I stumbled upon this blog….TOO CUTE.
Melissa Johannesen recently posted..Guest Post!
Megan @ runningonjava says:
So pumped that we're both done. Question…how is it drinking a hot drink out of a straw? I've seen so many people who do it, but I've always wondered haha. Hope your Christmas festivities were a blast!
Megan @ runningonjava recently posted..I'm home!!!
Sugar Coated Sisters says:
It took a while to get used to, but it's not bad! I'm just worried about staining my teeth so I try to drink as much tea, coffee, and soda out of a straw as I can!
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University of Wisconsin Stout | Wisconsin's Polytechnic University
Academic Programs
Get Your Hands on Your Future
Student-centered learning in degree programs that fully engage you in the classroom and in the real world.
Get Your Hands on Your Future
Student-centered learning in degree programs that fully engage you in the classroom and in the real world.
Psychology is the systematic study of behavior, particularly the behavior of individuals, their actions, reactions and motivations. The goal of this program is to prepare you to contribute to the improvement of the human condition. If you care about people, and want to help them, a bachelor's degree in Psychology is a great place to start.
The major, in combination with course work in communications, mathematics, humanities and natural and social sciences, fulfills the requirements of a liberal arts degree, which meets the criteria for graduate school or for an entry-level position in the work force.
As a student entering the program, you should realize you must obtain graduate-level education or other advanced training before being accepted as a professional psychologist. The majority of students continue their education at the graduate level. The Psychology program at UW-Stout is designed to enable you to select the courses and experiences which best match your personal interests and your planned career path.
As one of our 350 to 400 students, you'll be exposed to a strong foundation in psychological theory and application, and a wide variety of viewpoints for understanding behavior.
Algebra, writing and science are recommended as important course background if you want to study in the psychology program. Advanced math instruction can be useful in understanding research. Computer skills and work experience also prove valuable.
As a beginning freshman, you'll meet with the program director and your first-year advisor during your summer orientation and receive information and assistance regarding appropriate courses and scheduling needs. The required course work is begun the first semester and built upon each semester after. You are advised to enroll in courses in a timely fashion. This provides continuity for development of knowledge.
Each course in the curriculum has been developed to build upon previous knowledge, providing you with the opportunity to learn and grow as you master the concepts and principles of psychological thought. You also have the opportunity to investigate specific professional applications such as clinical, counseling, developmental, experimental, social and applied psychology.
As you progress to more advanced course work, you'll develop a strong foundation in research methodology. Opportunities for hands-on learning are available in the research and experimental laboratories, and include faculty support for you to design and develop personal research projects. Possibilities for personalized learning through field experience and work cooperatives also exist. One of the unique aspects of the undergraduate program is the opportunity for you to learn through personalized experiences under the guidance of a faculty member.
A high percentage of graduates go immediately into graduate programs, either for master's degrees in school counseling, mental health, human resource management, or into programs in clinical or cognitive neuroscience or experimental, developmental or applied psychology. A small percentage of graduates go into professional studies in law, medicine or science.
Because the program offers an opportunity for students to develop strong critical thinking and problem-solving skills, many graduates go directly into the work force and are employed in a variety of areas. Many find employment in the human services areas of preprofessional counseling or social work. Others go into management, sales, business or human resource management.


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Updated: March 11, 2005
Lyme disease is caused by infection with Borrelia burgdorferi, a spiral-shaped (spirochetal) bacterium carried by deer ticks and western black-legged ticks. The ticks are often infected by feeding on the blood of the white-footed mouse, the white-tailed deer, and various species of birds, though these animals do not spread the disease to humans.
Most (80% to 90%) of people infected with Lyme disease develop one or more red, slowly expanding "bulls-eye" skin rashes at the tick bite sites (these are called erythema migrans), often accompanied by fatigue, fever, headache, stiff neck, muscle aches, and joint pain.
If diagnosed early, Lyme disease can be treated successfully with antibiotics. If the disease is left untreated, some people will develop more serious health problems such as arthritis, problems with the nervous system, pain in the large joints, and rarely, heart problems.
Lyme disease was first recognized in the United States in 1975. The number of annually reported cases of Lyme disease in the U.S. has increased approximately 25-fold since national surveillance began in 1982; during 1993-1997, a mean of 12,451 cases annually were reported by states to the CDC, and the incidence is increasing. The disease is mostly found in the northeastern, mid-Atlantic, and upper north-central regions of the U.S., and in several areas in northwestern California. Lyme disease is the most common vector-borne (spread from one host to another through a carrier such as a mosquito, fly, louse, or tick) disease in the U.S.
In 1998, the Lyme disease vaccine, LYMErix, was approved for use in people 15 to 70 years old. However, the vaccine was removed from the market by the manufacturer (GlaxoSmithKline) in February 2002 due to lack of demand.
The majority of those immunized (about 70% of those age 15-70 years) experience no side effects. Of those who do have a side effect, most are mild and limited to the injection site, including soreness (in 24.1% of vaccine recipients) and redness and swelling (in less than 2% of vaccine recipients).
Approximately 3% of those immunized experience fever, chills, or a general sense of feeling unwell that lasts for one to two days.
Though concern has been raised regarding the potential for vaccine-induced arthritis in recipients with the HLA-DR4 gene, no serious reactions have been confirmed.


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You can buy alli online or in store. For a limited time, print a $10 off coupon and you can save $10 off your next in store purchase of alli.
To buy alli online simply click one of the logos below, or to find your nearest retailer, just enter your address or zipcode.
Remember, for the best results, start at the beginning – the alli starter pack contains the support and information you need to help alli work for you.
Just enter your address or zip code to find alli near you.
©2013 GSK. All Rights Reserved. This site is intended for U.S. residents only. alli, myalliplan, Shuttle, the Shuttle Carry Case, and other designs are trademarks of the GSK group of companies. alli® (orlistat 60mg capsules) is a weight loss aid for overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet. Follow label directions.


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Identical Twins Do Not Have Identical DNA
A study that was published in 2008 blows away the belief that monozygotic twins, also called identical twins, have the same DNA. Geneticist Carl Bruder of the University of Alabama at Birmingham and his colleagues studied the genomes of 19 pairs of adult identical twins and found sites of genetic divergence in each pair. Such divergences occur when there are a different number of copies of the same gene, a genetic state called "copy number variants." For example, one twin in Bruder's study had a genetic marker for leukemia – specific genes on particular chromosomes were missing. While this twin did indeed suffer from leukemia, the other twin did not.
This complicates the numerous twin studies that take place in the scientific world, including ones that explore the root of sexual orientation. While it doesn't necessarily nullify conclusions reached during said studies, it does contradict the belief that any difference found in identical twins could only be attributed to factors that were epigenetic (having to do with the way genes are expressed during development) or otherwise environmental (the "nuture" factor).
Organizations like NARTH who claim to have science on their side will eagerly point to studies that show up to a 50% twin concordance for homosexuality, claiming that anything less than 100% "proves" that a "gay gene" doesn't exist. And even Exodus International, a Christian organization that focuses on spiritual healing of homosexuality is an affiliate of NARTH and has this blurb on their site:
Current scientific research simply does not support the "gay gene" theory.
Researchers from all points of view have not found a 100% correlation among identical twin studies in their study groups. If homosexuality is solely a genetically based trait, there should be no variance among identical twins that share the same genetic history.
A search for the term "gay gene" on Exodus' site yields 20 results, all in articles ranging from outright denial of genetic influence to defensive posturing that genes might determine some aspects of our lives, but not our morality.
The term "gay gene" is of course an archaic and scientifically inaccurate one, not used by anybody trying to propose a serious argument for the biological origin of non-heterosexual orientations. There is no gay gene just as there is no "left-handed gene," though the latter trait is accepted unquestionably as biologically originated. Additionally, no serious scientific claim has been made that sexual orientation is "solely a genetic trait." close attention has been paid to factors that influence gene expression, exposure to hormones in the womb, and physiological traits found to be common among those of a particular sexual orientation.
But now thanks to this research, scientists in all fields have a better understanding of why identical twins are so rarely completely the same – and a better understanding of why, despite genetic factors influencing to a point, one twin may be gay while the other is not.


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StreamAPI API
StreamAPI enables users to incorporate live streaming video into their website or application. StreamAPI keeps track of viewership through reporting and analytics services. High definition video (HD) is supported using Flash technology, including support for full HD using VP6 and H.264 with 16:9 widescreen aspect ratio. The Stream API allows developers to embed videos into their websites.
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text:
Dream Angels Desire
Eau De Parfum
WFor Women
Item #
Dream Angels Desire
Eau De Parfum
WFor Women
Item #
Other Brands by Victoria's Secret
- Breathless
- Dream Angels Divine
- Dream Angels Heavenly Flowers
- Sexy Little Things Heartbreaker
- Sexy Little Things Love Rocks
- Sexy Little Things Noir
- So In Love
- Very Sexy
- Very Sexy 2
- Very Sexy Dare
- Victoria By Victoria
- Victoria Secret
- Victoria Secret Basic Instinct
- Victoria Secret Body By Victoria
- Victoria Secret Bombshell Forever
- Victoria Secret Dark Orchid Seduction
- Victoria Secret Fearless
- Victoria Secret Forbidden
- Victoria Secret Glamour
- Design House: Victoria's Secret
- Fragrance Notes: ivy, magnolia and freesia mixed with yellow plum, frangipani and pink peony
- Year Introduced: 2006
- Recommended Use: casual
No reviews written for this product
I purchased the Dream Angels DESIRE by Victoria's Secret. I am very happy with the product, for the size it was a bargain & got it pretty fairly timely.
Written by G. G. Rojas on June 23, 2014Read Review details ►
I love this scent. It has flowery undertones but kind of powdery, too. It will not disappoint you or your special someone! I get lots of compliments on this.
Written by Simply Me on June 16, 2014Read Review details ►
Victoria's Secret, Desire, is an absolutely amazing fragrance! You won't be disappointed with this purchase. I get at least 2 compliments from total strangers everytime I wear it!
Written by Amanda on July 26, 2012Read Review details ►
Dream Angels Desire is the perfect scent for everyday use. I work at a casino so obviously there is a lot of smoke at my job but this parfum last all day/night and I get a lot of compliments from guest. I would highly recommend this fragrance if you want a lasting sexy scent.
Written by Tiff on December 22, 2011Read Review details ►
An excellent floral perfume that is one of my favorites that I'll always keep buying. I get a lot of good compliments about it. You can't go wrong with this one for personal use or as a gift.
Written by Sonya on November 29, 2011Read Review details ►


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I didn't
enjoy this book as much as I thought I would. The conflicts
were few and shallow; they didn'yave much to do with the
story. However, this would be a good book for new readers.
The language isn't very difficult, and the plot is easy to
follow. Most of the characters seemed to be shifting and
occasionally, they would do something unnatural for their
character. I would recommend this book to a lower age and a
lower reading level.
Reviewer Age:14
Reviewer City,
State and Country: Shippensburg, Pennsylvania USA
Cassel teen books middle school books ya books ya series books book books fantasy books history books newbery newbery books newberry books newberry read author reading Young Adult teen teen reading reading lists summer reading lists summer books vocabulary teen travel young adult travel new books new teen books book reviews new book releases new books new young adult books fiction nonfiction historical nonfiction Penguin books penguin books puffin classics civil war books antietam middle school projects good books used books donate old books donate books used baseball cards advance book reviews pengun pengin teen gifts young adult gifts middle school reading list electronic dictionaries electronic dictioneries electronic dictionarys


text:
Browning BR-1030-UHF 3-5/8-Inch Magnet - NMO Mounting with Rubber BootChromed-zinc Magnet Housing. Solid Brass-chromed Nmo. Gold Contact Pin. Soft Rubber Boot On Magnet For Scratch Protection. 17 Ft. Rg-58 A/u Cable With Tinned-copper Braid 95% & Tinned-copper Stranded Center... Learn More$27.99
Browning BR-140 CB Land Mobile AntennaTop Quality, Manufactured by BROWNING.. Part Number:... Learn More$33.99
Browning BR-1024-UHF Adjustable NMO Trunk MountAdjusts Mount For Uneven Surfaces. Stainless Steel Mount. Chrome- Plated Solid Brass Nmo. Fits Up To 3/8" Surfaces. 17 Ft. Rg-58 A/u Cable With Tinned Copper Braid 95% & Tinned, Copper-stranded Center... Learn More$29.99
Out of stock


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|24th May 2011, 20:32
Sorta New Member
JM Hammerhead
ISC Hammer-MEG
Join Date: Mar 2007
Location: Norfolk, VA USA
Posts: 660
Trimix Fills in Virginia Beach, VA
Visited Joel Michello today, who runs Dive Services Inc in Virginia Beach, VA, and was I impressed. He dives + supports RBs too, so he's a good man to know if you're diving VB or coming this way. Here's his site: Dive Services Home
As you can see from the pixs, he runs a very clean operation. IANTD certified (or whatever you call it) and is very professional. He will also pick up your tanks from the dive boat and deliver them filled for your next morning dives (we usually stay on the boat at the dock when we're diving the next day).
Sorry if I sound excited , but a good fill shop around here (these days) is a rare find. Most of us have had to resort to building our own fill stations at home.
Bill Ripley
Rebreathers are something that we have to go to in order to dive the way we want to dive. They are not something we go to for any other reason.
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Fancy Colored Diamond Engagement Rings
Think of a precious diamond and what comes to mind would be a perfect stone and colorless. But the truth is that fancy colored diamond is actually more expensive and precious than any jewel traditional elite. There are several factors that determine the credit worthiness of colored diamond engagement rings as the inherent perfection, color and a certain intensity and rarity of the gem.
In principle, a pure diamond, the crystalline form of carbon and would be free of additional minerals or elements that may distort the stone and its structure. However, certain other elements in the chemical composition of most natural diamonds are incorporated as they form. These additional elements that add color stones. The stone color varies, what are other elements of the crystal structure dependent. Absorption of radiation is another way in which the color of the diamond profits. This happens when the crystals deformed rock or bent to absorb light in different ways. Thus, the stone in different colors are even in the absence of other chemicals.
The quality and value of fancy colored diamond engagement rings is determined by different criteria. In general, all diamonds, regardless of the color for its carat weight, clarity and precision cutting and the fourth factor is the color can be assessed. In fantasy colored diamond, the tone is obviously the most important factor in assessing quality. Know there are three elements of the stone, meaning the total value of the particular shade of color, texture and intensity. To be precise, we can say that the stone would have more value if the color is deeper. This is more efficient in bright colors like yellow and pink. A fancy colored diamond elegant appearance in the sense of bold colors is not affected by gradients or other variations. However, deficiencies are evident in the colored diamonds, which are not confused with the refraction of light into colors.
The stone quality and clarity that the price determined by rhinestones. A small stone, with rich colors would be more useful than a large stone with an average quality. Therefore, the colored stones are more expensive than comparable colorless diamonds. So many couples go for colors and so affordable alternatives.
If you want to make the best use of colored diamond engagement rings, you need a simple ring design choose not detract from the beauty of the stone. The setting should not to conquer high point of the stone. In addition, emphasis should also block the main color diamond competition. Although choice of the metal ring make sure to avoid the contrast. Normally, white and platinum are preferred because they are strong enough to protect a precious stone. And its neutral color would not be the diamond in the ring.
Since colored diamond engagement rings rare and prestigious, the desire by the engagement rings and other fine jewelry. Couples can choose wisely budget diamonds input for understanding the reasons for the color of diamonds and how the color has a special value.
Also read about heart shaped diamond engagement rings and engagement ring designers


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Sacramento County District Attorney
Jan Scully
I began my legal career as a deputy district attorney in this office in 1979. Before being elected district attorney in 1994, I worked my way up through the ranks and was proud to supervise teams in our Felony and Sexual Assaults and Child Abuse bureaus.
Throughout the years, I have been very proud of the hard work, integrity, and dedication to public service that have characterized my colleagues. As district attorney, I appreciate their long hours, their energy and ingenuity, and their unfailing good humor.
We are committed to providing the highest level of public protection in Sacramento County, both in the courtroom and in our community. This office prosecutes cases brought to us by almost 40 state federal and local agencies, with the Sacramento Sheriff's Department and Sacramento Police Department accounting for the great majority of these cases. I am proud of the strong, positive, working relationships we have with all these agencies and their leaders.
We have designed this website in an effort to better inform the public we serve. I hope it will help you to learn about the work performed at this office, as well as enable you to have your individual questions and concerns addressed.
In these times of shrinking financial resources, we have endeavored to form a partnership with communities, businesses, and other agencies in order to make Sacramento a safer place in which to live, work and raise our children. Ingenuity, integrity and hard work by this office have paid, and will continue to pay, dividends in public safety.


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Morgan Stanley: Euro Rebound Winner
By Philip van Doorn - 07/27/12 - 4:39 PM EDTTheStreet) -- Morgan Stanley
The shares trade for 1.4 times their reported June 30 tangible book value of $5.30, and for nine times the consensus 2013 EPS estimate of 84 cents. The consensus 2012 EPS estimate is 75 cents. Based on a quarterly payout of eight cents, the shares have a dividend yield of 4.43%. Interested in more on First Niagara Financial Group? See TheStreet Ratings' report card for this stock.
Interested in more on Morgan Stanley? See TheStreet Ratings' report card for this stock.
Email. Follow @PhilipvanDoorn
Latest news from section
Regional Banks Shine at End of Rough Week for Sector
Capital One, Wells Fargo Rise While Most Big Bank Stocks Fall
Bank Stocks End Mixed as Investors Look Ahead to Capital Plan Announcements
State Street Leads as Bank Stocks Investors Look to Wednesday
See all news From Financial Winners & Losers


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Medium Wavy Casual Hairstyle
This fun and flirty hairstyle has jagged cut layers through edges to allow a textured finish and lightens the ends for a weightless look. Smoothed out bangs are added to frame the face and completes the look perfectly.
- Hair Category: Casual
- Hair Length: Medium
- Hair Elasticity: Wavy
- Gender: Women
- Face Shape: Oval, Oblong, and Diamond
- Hair Density: Thin/Medium
- Hair Texture: Fine/Medium
- Age: Under 21, 21 - 30, 31 - 40, and 41 - 50
- Height: Any
- Weight: Thin/Average/Large
- Glasses: Without glasses suits best
- Styling Time: 30 minutes
- Products: Mousse, Wax, and Hair Spray
- Styling Tip: Using the wax, piece out sections with your fingertips to achieve this look.


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Check the Office of International Education out on. . .
"EducationUSA centers are the U.S. State Department's network of hundreds of advising centers in 170 countries designed to assist local students find the appropriate college or university in the United States. Click on the link below to find your center!"
Health care in the United States is very expensive. A simple visit to a doctor can cost hundreds of dollars and staying in the hospital for a couple of days may cost a fortune. Therefore, health insurance is required at IPFW for ALL international students. A health insurance plan offered by IPFW is available to ALL international students, therefore, a foreign health fee will be added to your bill each semester. Your insurance card will be available for you to pick up from the International Student Services Department two weeks after it has been ordered.
IPFW offers Rust & Associates health insurance to ALL international students. The current insurance rate is $86 per month. You will be billed for the health insurance per semester at the following rates:
Fall semester (coverage from August 1 to December 31): $490
Spring semester (coverage from January 1 to July 31): $686
If your spouse and/or children are accompanying you on F-2 visas, you can list cover them under your rust International insurance policy. The extra cost for spouse coverage is $248 per month. The extra cost for each child is $124 per month.


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|Product #: EMC6311072_TQ
Multiples of 8 (multiplication) (Resource Book Only) eBookGrade 3|Grade 4
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Please Note: This ebook is a digital download, NOT a physical product. After purchase, you will be provided a one time link to download ebooks to your computer. Orders paid by PayPal require up to 8 business hours to verify payment and release electronic media. For immediate downloads, payment with credit card is required.
A math activity in which a student colors a square that contains a multiple of 8, finds the name of a sea creature, and draws a picture of the creature
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It's Cultural Deviancy NOT Guns
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Optimum Homo
Tactical Neck.
Join Date: Jan 2005
Location: Colorado
Posts: 22,732
Due to some interesting report this post emails from this thread, I am feeling compelled to post this, yet again, as a reminder about this particular subforum:
Goooo "team that reflects my political ideology!" WARNING! This is a loosely moderated forum. Frankly, moderating political discussions is about as fun as sitting in on Raider court proceedings.
This is the descriptor for the WRP forum. This forum is loosely moderated BECAUSE it is a religion and politics subforum. The mods will not handhold certain posters because other posters are being mean to them.
Which brings me to another reminder for certain posters, from the OM Guidelines:
Moderators are volunteers who have demonstrated a love for the Denver Broncos, as well as the Orange Mane community at large. They are tasked with being the standard bearers of this community – though they are all fallible. The mods are just people who love the Broncos, love this discussion forum, and are trying to do the best they can with the tools they have.
If you never have anything nice to say about a mod, then you probably shouldn't say anything at all – and frankly, you might consider finding another community where you think the mods and guidelines are more to your liking.
This forum is not going to tolerate the faithful servants of this forum being publically ridiculed for their service any more than it will tolerate the posters being punished arbitrarily. We strive for balance in everything we do – and most of the time, we succeed (nobody is perfect).
We now go back to your regularly scheduled slap fight.
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