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Dr. Goldstein has five offices in New York.
Specializing in the field of Internal Medicine, Dr. Goldstein is prepared to provide care to adult patients suffering from a wide range of illnesses and diseases, ranging from the very common to the very rare. Dr. Goldstein is also trained in general medicine, and is capable of treating patients for diseases that may have overlapping symptoms or complications. Dr. Goldstein is also trained to practice Pulmonary Critical Care, Pulmonology and OBGYN / Obstetrics & Gynecology.
Dr. Goldstein works with twenty-four doctors including Dr. Bryan Green and Dr. Ari Paley.
Treats adult diseases – internists are known for diagnostic skills and the ability to manage multi-system diseases.
Offers care for patients with critical respiratory complications (mainly the lungs, trachea and diaphragm).
Provides care for disorders of the respiratory system, such as asthma.
Provides care for the female reproductive system in both the pregnant (obstetrics) and non-pregnant (gynecology) states.


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Persistent Systems
ADCC Infocad Pvt. Ltd.
Spandan is an annual event organised by Yeshwantrao Chavan College of Engineering (YCCE), Nagpur since last fourteen years. It is a National Conference on Advances In Engineering, Technology and Applied Sciences. This year the conference is organised by Department of Computer Technology on 21st and 22nd of March, 2014. The event includes keynotes addresses by eminent personalities, paper presentation sessions and poster exhibition.
The conference is intended to provide a platform for researchers, student of engineering and applied sciences to exchange their ideas and to share the emerging technological developments in their repective areas. Every year about 500-800 students participate in this conference. It provides the platform to the students of UG, PG programs and Ph.D. scholars for exhibiting their research talent. It is one of the most popular conferences among students in different parts of India.
Yeshwantrao Chavan College of Engineering was established in 1984 by Nagar Yuwak Shikshan Sanstha, Nagpur is an Autonomous Institution affiliated to Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur. YCCE is renowned for engineering education and research. For over 29 years, it has successfully nurtured young engineering professionals, becoming a sought after destination for students aspiring pursue higher technical education and placement in the competitive software and core industry.
The college is guided by Academic Advisory Board consisting of eminent academicians from prestigious technical institutions in India and different parts of the world. The college is having well qualified and experienced faculty members.
YCCE has become the first private engineering college to acquire "Autonomous Status" in the Central India. The institution is implementing autonomy in progressive manner from academic session 2010-11.

subset: commoncrawl


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Monday, December 22, 2014
2011-08-23 11:25:00
ClubWPT Membership Review - Enter Bonus Code 'THEKING' and Get 2 Weeks Free
The World Poker Tour (WPT) is a high-profile poker tournament series that attracts the top professional players from all around the world. Each year, it's one of the biggest and most prestigious international poker events.
In 2008, WPT launched a subscription-based serviced called ClubWPT. ClubWPT allows anyone, including all those under served US players, to get in on the action by participating in a WPT series of online poker tournaments.
The WPT often markets their ClubWPT product as "the best legal US poker room," and this is what has distinguished them from so many of the other options. So how does ClubWPT beat the system in order to cater to US players?
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Posted on: 2014-03-24 20:59:00
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Rather than another shirt, why not hand out a book, such as Ben Hogan: The Man Behind the Mystique? Better yet, for about $40 to $50 per person (with a minimum order of 100 books), bring in one of the authors for a BOOK SIGNING. The author might even have time to stick around and speak to the group, says Martin Davis, editor and publisher (and co-author) at The American Golfer, Greenwich, Conn. Also from the company: The Golfer's Book of Yoga, by Drew Greenland. The book ($28) shows how ...
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A classic costume made even more creepy! The Skeleton Zombie costume includes Skeleton mask with gauze, Shirt with showing through rib cages and gauze, pants with gauze and leg bone showing through, and gloves to make your hands look like skeleton bones. 4-piece set. Polyester. Hand wash. Imported.
Does not include shoes.
Retail Value: $74.99
Our Price: $59.99
Product ID: #68384
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Title: The Hit of the Party
Date: Nov 04, 2011
when i first saw the costume I thought it would be ok .. When I received it I was amazed at the quality and appearance. Everyone wanted to know where i got it.. And I was very pleased to tell then celebrateexpress.com Everyone at the party had to take a turn getting their picture taken with me in it.. It was a hit..
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Post-Civil War Texas was a land of opportunity due to a vast amount of farming and grazing land, coupled with the newly built railroads. Many immigrants came here to start a new and hopefully prosperous life. John Campbell, an immigrant from Ireland, built a one-room cabin that he later enlarged for his twenty-three family members when they came to Texas around 1850. Descendants of the Campbell family lived in the cabin until 1952. In the late 1970s, the Hoermann family donated it to the Conservation Society. In 1979 it was moved to its present location at 211 E. Live Oak Street. It houses numerous interesting artifacts, including a 145 year-old quilt and a 1908 icebox.
Kay Martin, SCS member, says her favorite thing about the cabin is the feeling she gets when she steps on the front porch. "It feels like you just stepped back in time; like you are at a home, not a museum." She also says that people should remember that the porch at the Log Cabin is a great place to take photos. "The trees and porch are quaint and rustic, and best of all, it's free!" she says.
For a guided tour of the Campbell-Hoermann Log Cabin, call Marty Keil at 830-560-6291. The Log Cabin will be open for Seguin's Birthday Party on August 11th, so come see this and all the historic buildings the Conservation Society is privileged to maintain.


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TV Account Executive- £26K - Beauty FMCG!!!
Ultimate Asset London (Central), London (Greater)£22000 - £28000 per annum
The Role
This is truly fantastic opportunity to work with big spend clients on fantastic brand campaigns across predominately TV but also VOD, cinema and Sponsorship. The client list is one of a kind ranging from top sports brand to high class automotive brand. This is one of the most sort after TV roles in the market and will not be around for long. You will be sitting in a division which is dedicated to getting the best out of each person and pushing creative boundaries.
- Predominantly TV planning and buying.
- TV is the main platform but there is opportunity to work across other platforms including VOD, Cinema and Sponsorship.
- Planning with Budgets in excess of £12million across different campaigns.
- Negotiating rates with award winning media owners.
- A very client facing role- building up longstanding relationships with top media owners throughout.
- This is the perfect role for someone who is ready to take on more of a challenge in a supported environment.
The Person
- 18 months- 2 years TV buying within a media agency experience is required and a good understanding of planning is also a must.
- A solid understanding of industry related tools.
- This role demands someone who is incredibly analytical and organised.
- An understanding of planning and buying across different TV platforms.
- A true passion for TV!
The Company
My client are an award winning global media agency, currently looking for someone who has the same passion as they do to join their team. Working across multiple big budget client accounts, this is not an opportunity to miss out on. Although this is a global media agency it still holds a close knit family feel, whilst also offering fantastic career progression.
Apply now for this cracking opportunity to work as a TV Account Exec!
- Posted
- 21 June 2014
- Closes
- 19 July 2014
- Ref
- Contact
- Emily Brennan
- Sector
- Advertising, Advertising Agency, TV
- Function
- Media Planner / Buyer
- Hours
- Full Time
- Contract Type
- Permanent
About Ultimate Asset
Ultimate Asset recruits at all levels across offline and digital. We recruit for leading media owners and media agencies. We believe in developing long-term, trusted relationships.


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Tuscan Chocolate Valley producers Paul de Bondt and Cecilia Iacobelli are the stars of this video. Kristina Feb 15, 2010 252 views
© 2014 Created by Clay Gordon.


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Find a Doctor
With over 400 board-certified physicians, Albany Med Faculty Physicians
are some of the most expert in their field. Find the right
physicians who meet your medical needs.
Joseph Roglieri DO
Board Certification:
American Board of Internal Medicine, 2006
American Board of Internal Medicine, 2004
(Internal Medicine)
Contact Information:
Northeast Nephrology Associates, PC
258 Hoosick Street
Suite 101
Troy, NY 12180
Tel: (518) 274-5660
Fax: (518)274-5666
07/01/2004 - 06/30/2006
Winthrop University Hospital
Mineola, NY
Internal Medicine
07/01/2001 - 06/30/2004
Winthrop University Hospital
Mineola, NY
Medical Education
- 06/03/2001
Philadelphia College of Osteopathic Medicine
Philadelphia, PA


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Why is it so easy to power through a day of teaching/practicing Yoga, Pilates, or other fitness classes, but so difficult sometimes to go to the grocery store or think about planning and executing a simple meal?
Every now and then my husband has to have "the talk" with me. We've been together over 20 years and married for 13. He definitely knows how I am and what he was getting into. I admit I used to be better when we lived in the suburbs and drove a car to the grocery store. It was easy to just load up & buy a ton of stuff then think later how we wanted to put it all together. Now, living in various cities the last several years have really presented me with a new challenge. The challenge of walking or riding my bike to and from teaching 15 classes a week plus my own personal practice leaves not that much time or should I say desire to then walk back out to get the damn groceries. After all, we always have time for what's most important to us right? I know, I know…just pair the grocery trip after a class on the way home. That's a great idea, but I'm usually hungry, tired, already have some sort of heavy bag with me and forget about even thinking about a shower or trying to do something different with my hair besides the "maybe if I leave it in a pony tail it won't look as greasy" look.
Yes I try to keep some sort of bar in my bag for the post-class snack so that if I do make it to Trader Joe's I'm not ravaging the shelves in some sort of feeding frenzy then later having to stop on the way home to drop the bags and take a break while thinking "why did I buy all this crap at once?!" Because I was in a post-class hunger trance, that's why (hence the Garlic & Parmesan Pita & Everything Bagel Chips). Let's face it, some days I'm just lucky to get myself out the door without having to sprint to class and maybe, just maybe do I remember my water bottle!
How do some of you do it with kids? I really don't get it!
A natural response might be "Why can't your husband do the groceries?"
He too is a sports enthusiast and in the summer was cycling 250 miles to and from work per week. Now with the colder weather he's doing the train/carpool combo making his commute about 3 hours a day. Let's just say given that he works 50 hours a week at a high stress job while I work less than 20 teaching Yoga & Pilates there's really no feeling sorry for me! I'm just a deadbeat. That's all there is to it and admitting it is the first step towards recovery. I don't cook (although I like to when the ingredients are handy), I clean some, but it's certainly no hobby. I do laundry once a week (hey, there's a plus). While I'm thinking about the positives…I do juice several times a week. That's huge! Doesn't that balance out some of the not so greats?
Let me make this clear. I'm not looking for pity. I'm simply voicing a frustration…a challenge I struggle with… another step towards finding that balance that we at YOGANONYMOUS seek. I figure there's probably others out there like me who'd rather sweat it out on the mat hours than set foot in a freezing cold grocery store that plays hideous music while some unsavory character touches your veggies…no I got it, thanks! [Disclaimer – that was NOT a Trader Joe's reference].
So, thanks for listening. Who would have thought the path of transformation would include trips to the grocery store?


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Use Drug Development Data More Intelligently
FDAs Critical Path initiative outlines ways to bring more efficiency to the drug development process. The key to better knowledge management during this critical period is utilizing data more intelligently. Michael Eckstut and Sam Venugopal of the IT firm Conformia outline the challenges and potential solutions in this 7-page PDF document.
Author: Michael Eckstut and Sam Venugopal, Conformia | File Type: PDF
Find more white papers on Process Operations, Automation & Control


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MidiYodi 3.0 released.
MidiYodi 2.6.1 released.
MidiYodi in the world.
MidiYodi on Facebook.
MidiYodi 2.6 released.
MidiYodi is an application that allows examination, playback, editing and conversion of MIDI files.
MidiYodi is available on all major platforms including Windows, Mac and Unix.
MidiYodi contains a rich set of features such as:
MIDI File Examination
MidiYodi provides various tools to examine the layout and content of a MIDI file.
MIDI File Editing
MidiYodi offers a rich set of tools to edit the content and structure of a MIDI file.
MIDI File Playback
MidiYodi offers several navigation and playback controls.
Jukebox - Playlist Management
MidiYodi provides a Jukebox that allows several MIDI files to be managed in playlists and played sequentially.
MidiYodi Customization
MidiYodi offers some useful and nice customization features. (View)


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Getting good video footage of these relatively small but very fast models is difficult. But here are a selection we have found or have created ourselves.
F5D is faster than F3D
- Details
- Written by Darron Rodrigues
Here's a short video from Wings and Wheels 2010.
The BMPRA were lucky enough to have a stand and some flying slots, so we put both an F5D and F3D model up at the same time to entertain the crowds.
I think that out of a dive F5D is significantly faster, but doing the short laps they were about the same, which if you consider how the tuned pipes and electric motors work makes some sense.
Video - Barkston June 2010
- Details
- Written by Darron Rodrigues


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Superheroes Fancy Dress
Here our Superheroes Fancy Dress come to save the day! Welcome to our range of child superhero fancy dress costumes suitable for boys and girls. This category includes some very popular kids fancy dress costumes, such as Supergirl, Batman and Robin and everyone's favourite, Superman. Years ago we would have to make do with a cape made from old bed sheets which called for a huge amount of imagination. Fancy dress has come on leaps and bounds since then, so whoever the character, we are sure to have the outfit to transform them into the spitting image of their hero. Often derived from comic books, superheroes make a great choice for a world book day outfit. Whether its for school, as a gift or to simply top up the dressing up box, these Superhero costumes are sure to be adored.
Child Superman Returns Super Hero Costume
£9.95 Show me more
Child Muscle Shirt
£9.49 Show me more
Child Hulk Costume
£11.45 Show me more
Child Man of Steel Reversible Cape (Superman/General Zod)
£8.99 Show me more
Child Deluxe Zorro Hat
£8.49 Show me more
Child Man of Steel Superman Cape
£5.99 Show me more
Child The Dark Knight Rises Batman Cape & Mask
£8.99 Show me more
Child Supergirl Super Hero Costume
£16.49 Show me more
Child The Flash Super Hero Costume
£12.49 Show me more
Child Amazing Spider-Man 2 Deluxe Costume
£17.99 Show me more


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Only one game was on the tip of everybody's respective tongue this week and that was Grand Theft Auto V. In a typically ballsy style Rockstar released the debut trailer for what has to be the most anticipated game on the planet and even though the finer details are still to be confirmed, that didn't stop the internet from exploding with speculation.
However there were some other cool videos released over the past seven days and for your convenience we've catalogued them right here in this week's Something for Sunday. How nice are we? So without further ado here are our picks:
GTA V Looks Slightly Better Than San Andreas –
It's been seven years since GTA: San Andreas was released, so it's about time Rockstar revisited what is arguable most people's favourite entry in the series. One particular fan has tried to recreate the trailer for GTA V using only the tools present in San Andreas and the comparison is surprisingly apt. Although we're sure the 2004 release didn't look quite that bad when we played it all those years ago.
Battlefield 3 may currently be everyone's favourite online pastime, but spare a thought for Halo. The first shooter which truly popularised competitive online play on consoles has been celebrated utilising only LEGO bricks before, but this short trailer gave us a stark reminder of online arenas we haven't visited for a while now. We don't miss the trash-talking teenagers occupying servers or the regular humiliation that accompanied a good tea-bagging, yet for some reason we still have the urge to occupy a power suit and head online once more. How bizarre…
After constant rumour and speculation Ubisoft has finally unveiled the next game in the Rainbox Six series and it looks to be a very sobering experience if this lengthy gameplay demo is anything to go by. The graphics shown in this footage are only target visuals, but still this looks to be a relatively original voice in the increasingly crowded FPS genre.
Last but certainly not least we have another long gameplay video, only this time supplemented by commentary from IO Interactive's Christian Elverdam and Tore Blystad. These guys seem very proud of their work on the next game in the beloved Hitman series and frankly we can see why. The new engine offers up far superior visuals to anything seen in the series before and that trademark griefing gameplay style which has won so much acclaim in the past seems more than accounted for. Forget all the speculation about Absolution being a more casual experience – just check out the gameplay footage for yourself and make your own conclusions.
As always if you see anything worthy of a mention in this feature on your internet travels, be sure to send an email to email@example.com describing your selection and we'll give you a shout out to recognise your contribution.
Tags: GTA V, Halo, Hitman Absolution, Rainbow Six
GRID Autosport, The Evil Within, Valiant Hearts, Space Hulk, Supraball and Homefront: The Revolution star in this intriguingly varied issue of our free-to-read .Download Now!


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May 29, 2014
Celebs Around the World!
Share with your friendsOur favorite celebs LOVE to share cool pictures on Twitter and Instagram, especially of themselves traveling the world. Whether for work or fun, celebs visit the most incredible places! Check out some of these amazing views! Share with your friends What do you think of this post?LOL (18) OMG (22) Luv it (48) meh (9)


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Kadner: Real mystery of the Robbins murders
By Phil Kadner email@example.com February 3, 2014 10:44PM
A shooting in the 13600 block of Pulaski in Robbins is being investigated by Robbins Police and the Cook County Sheriff's Department. | NVP
Updated: March 5, 2014 6:16AM
It was about 10:30 p.m. when the 14-year-old boy heard a "pop" from the lower level of his Robbins home.
He was in an upstairs bedroom, ran downstairs and "saw smoke coming from the head of a 17-year-old (boy) and blood coming out," Cook County Sheriff Tom Dart said.
It's such a small house, Dart would say more than once during the course of a conversation Monday morning.
"Such a really tiny house and such a horrible, horrible scene inside," he said. "Blood everywhere."
In all, four people in the house would die. Michael Worsham, 43, was standing over the body of his 17-year-old son, holding a gun when the 14-year-old (who told police he was a stepson) arrived on the scene.
Worsham then went upstairs to a bedroom, where his wife of 12 years, Michelle Ollie, 42, was in bed with her 5-year-old grandson.
"He pulled them out of bed and shot his wife," Dart said.
The 14-year-old began fighting with the father in an apparent attempt to save the life of the 5-year-old.
"He grabbed the gun and wouldn't let go," Dart said, "and at some point the husband promised he wouldn't shoot and would let the 14-year-old leave with the 5-year-old unharmed if he would just stop fighting him."
The boy released the gun, grabbed the 5-year-old and ran through the front door of the home. A 15-year-old daughter of Worsham attempted to follow them out.
"That's when he shot her in the back, and she fell on the front stoop," Dart said. "Of course, all of this is coming from the 14-year-old, but all of the evidence inside the house seems to verify his version of events."
You wonder what it must have been like for that young boy to see so many people die and to engage in a life-or-death struggle with an armed man with homicide in his heart.
"He's a strong kid," one law enforcement official told me. "I mean mentally and emotionally strong."
As the teen fled the house with the 5-year-old in tow, witnesses had gathered in the street outside the home. Worsham fired some shots at them.
"He then either shot the 15-year-old in the head while she was still lying on the stoop or dragged her body back inside and shot her in the head. In either case, he dragged her back inside the house," Dart said.
The 14-year-old took the 5-year-old to a neighbor's house, where police eventually would find them.
Robbins and Cook County sheriff's police arrived, went inside the home and found Worsham slumped over on a bed dead. There were no indications he was shot, stabbed or otherwise physically harmed.
Police are awaiting a medical examiner's report on the cause of death "because at this point we don't know what his motive might have been, and we don't know the cause of his death," a sheriff's spokesman said.
The principal at Shepard High School in Palos Heights, where all the teenagers in the house went to school, said there were no reports of family troubles.
"By all accounts, these were good kids, well liked by their classmates," Principal Josh Barron said. "We had their older siblings here in school as well before they graduated.
"We knew Michael and Michelle as responsive parents. By that I mean if we had anything we needed to discuss with them about the children, they were here. They were involved in their kids' lives. This is not something you would expect to happen to this family."
There were no reports of domestic violence at the home before the shootings Sunday night, police agencies report, and no one there had a criminal record. Relatives and neighbors told newspaper reporters that everything seemed all right.
Worsham was a security guard who had a valid firearm owner's ID card, required to legally own a gun in Illinois, and a PERC card, which is issued by the state and used to assure employers that a person has passed certain background checks through the use of his fingerprints.
"We don't have any motive right now," Dart told me, "but we're going on the assumption it was some sort of domestic dispute that escalated. We're really hoping to expedite the ME's report on the shooter because that could tell us a lot about what happened in that house."
People like their murder mysteries solved. It's not enough to know whodunit, but we've got to have a motive.
If someone snapped, there had to be a reason. Drugs. Alcohol. Infidelity. Financial problems. A history of mental illness.
No one wants to consider the possibility that someone (who appears quite normal) could one day grab a gun and suddenly murder his wife and two of his children.
Why let the other two kids go? Why keep his promise to let them escape?
He could have killed the 14-year-old and the 5-year-old just as he gunned down the girl.
Maybe something else will be learned in the next few days, details that will satisfy the curious and allow the rest of us to exhale a sigh of relief.
"It couldn't happen to my family," everyone wants to say. "Not in my neighborhood."
And then we can all forget that alcoholism, drug abuse, mental illness, financial woes and all the other boxes that get checked off during a murder investigation happen — even in the best of families, in the nicest of suburbs.
If you're waiting for me to blame the availability of guns, well, that isn't going to happen.
But anyone who dismisses the argument that guns make it easier to kill people is delusional.
The murder of three people in Robbins eventually will disappear from the headlines and our thoughts.
There will be another "horrific" murder of another family somewhere that will grab headlines and draw our interest for a few minutes.
Sometimes, it seems more like the stuff of science fiction rather than "Murder She Wrote."
Yes, another person murdered his family. Happens all the time.


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TGIF- Thank goodness it's fishy!
And let's never talk of that pun again.
This week in the oceans,
… NPR has a gorgeous photo slideshow from The Netherland Antilles reefs.
… if you are planning on vacationing on the beach, check out some helpful tips on what you can do to keep our reefs healthy.
… one Canadian council is fighting the good fight against shark finning.
… humans aren't the only ones that get grumpy with age. Moko, a dolphin famous in New Zealand for playing with swimmers, is getting aggressive as he matures. Just a reminder that though they are cute, dolphins are wild animals and not household pets.
… Migaloo, the albino humpback making a splash off the eastern Australian coast, likely has a tumor and low sperm count. Ouch.
… AJ, the Georgia Sea Turtle Center's spokes-loggerhead, is being released to the wild two years after he was rescued.
… a lucky leatherback in New York escapes from an encounter with a trawl net. If only all his brethren were so lucky.
… last week, 83 loggerhead hatchlings were poached from a North Carolina beach. The U.S. Fish and Wildlife Service is now offering a $5,000 reward for information leading to the culprit.
… an explosion in jellyfish populations causes trouble for the Monterey Bay Aquarium. The likely culprit behind the stinging swarm? Pollution.
… while some Monterey Bay Aquarium staff are fighting off jellies, others are researching the potential affects of ocean acidification on deep-sea animals. Learn more about ocean acidification and watch Plant Green's Blue August feature Acid Test: The Global Challenge of Ocean Acidification. Catch a sneak peek and check showtimes on their website.


text:
1911 Encyclopædia Britannica/Lee, Ann
From Wikisource
|←Ledyard, John
|1911 Encyclopædia Britannica, Volume 16
Lee, Ann
|Lee, Arthur→
|See also Ann Lee on Wikipedia; and our 1911 Encyclopædia Britannica disclaimer.
LEE, ANN (1736-1784), English religious visionary, was born in Manchester, where she was first a factory hand and afterwards a cook. She is remembered by her connexion with the sect known as Shakers (q.v.). She died at Watervliet, near Albany, New York.


text:
Representative Garcia is committed to transparency and accessibility in Colorado's government - and an important part of the legislative process is hearing from constituents.
If there is a particular bill that you care about, or an issue that you feel needs to be addressed at the state level, reach out to Representative Garcia using the contact information below.
Office of Representative Leroy Garcia
200 E. Colfax Ave
Denver, CO 80203
(303) 866-2968


text:
The Follow Fashion bloggers battle is almost coming to an end. This week outfit number 3 is in the spotlights. The theme was Sporty Chic this time and frankly, I didn't have a clue what to wear. Normally I'm not that sporty so it was quite hard to pull off a theme based outfit. Eventually, this is the result. Hope you guys will vote for me again!!
Thank you!
Vote here for my first look 'Leahter Touch' and here for my second look 'Autumn Outfit'.
iWear/ H&M pants & tee, RIVER ISLAND platform shoes, BIKBOK leather jacket, WEEKDAY hat


text:
Ex-Fla. House Speaker Suing State for Legal Costs
TALLAHASSEE, Fla. (AP) - Former Florida House Speaker Ray Sansom is suing the state for more than $800,000 in legal expenses after beating corruption charges.
His lawyer, Robert A. Harper, said Tuesday that he'd like to see the money come from the state attorney who prosecuted Sansom. But Harper conceded that's unlikely.
Harper said it was coincidence that Florida law requires such lawsuits against the state be filed against Tallahassee-based State Attorney Willie Meggs, who filed charges against Sansom and later dropped them.
The Destin Republican faced grand theft and other charges over earmarking $6 million so Northwest Florida State College could build an airport building allegedly for use by a co-defendant. The school then gave Sansom a $110,000 job. Sansom resigned from the college job and stepped down as speaker.
Related Stories
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- Fla. House set to approve $69.2 billion budget
- National blind convention speaker to address wages
- Support for Legalizing Marijuana at All-Time High
- Zimmerman's Attorneys Asking State to Cover Legal Expenses
- Average Cost for Thanksgiving Dinner
- Costly Crime Solving
- The Cost of FCAT Testing
- John Lewis Keynote Speaker for Get Out the Vote Rally


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ABiz presents:
Whitney Bank and The Allen & Gooch Law Firm return as presenting
co-sponsors for this prestigious event.
ABiz is pleased to announce that respected journalist Steven Coll will be the keynote speaker for the 2012 Top 50 Business Luncheon on Thursday, August 23, at The Cajundome Convention Center at noon.
|Whitney Bank Lafayette / Cenla Commercial and Mid Market Bankers: Seated left to right: Kenray Landry, Larry Attenhofer, William Hendrix, Duayne Richard, Byron Breaux, Jeff Blum and Nancy Trahan. Standing left to right: Brannon Menard, Nicholas Richard, Brent Benoit, Jonathan Richard, Kevin Shipp, Matt Bruyninckx, Greg Zaunbrecher, Mike Williams, Craig Pontiff, Harold Smith and Clegg Caffery
Whitney Bank and The Allen & Gooch Law Firm return as presenting
co-sponsors for this prestigious event.
ABiz is pleased to announce that respected journalist Steven Coll will be the keynote speaker for the 2012 Top 50 Business Luncheon on Thursday, August 23, at The Cajundome Convention Center at noon. This is the fourth annual event produced by the magazine in honor of the top executives who preside over the region's largest companies, ranked by gross revenues and based on research exclusive to the magazine.
|Allen & Gooch: Back Row: David Ayo, Keith Landry, Brian Perry, Mike Parker, Troy Broussard, Alan Meche, John Hughes. Front Row: Randy Theunissen, Raymond Jackson, Emile Joseph, Jody Zaunbrecher, Frank Flynn, Billy Parker and Clay Allen
Along with the law firm of Allen & Gooch, Whitney Bank returns as a presenting co-sponsor of the Top 50 Luncheon again this year. "On behalf of our directors, officers, and employees, I would like to congratulate all the top 50 recipients," says Duayne Richard, president of Whitney's Central Louisiana/Lafayette Region. "From Texas to Florida, throughout the Whitney/Hancock footprint, it is my observation that Acadiana is by far the most entrepreneurial area and this attributes to our amazing growth and prosperity. This is the reason America considers this area one of the most desirable places to live and work. We appreciate the recipients who allow us to serve their financial needs and welcome the opportunity to help others achieve their financial goals."
Allen & Gooch managing partner Clay Allen says his firm is pleased to be part of an event that recognizes Acadiana's business leaders and the unique qualities that drive their success. "We have had the privilege of working with many of Acadiana's top businesses and we have witnessed first-hand the innovation, the work ethic, and the bold vision that is a hallmark of our region's economic leadership," he observes. "We congratulate the Acadiana Top 50 Businesses for their corporate citizenship and for their role in our region's economic vitality."
Supporting sponsors for the event are The LHC Group and The Acadiana Economic Development Council, who will announce the winner of The Acadiana Honors Awards that day. The Pinnacle Group Financial Services returns as VIP Parking sponsor and Vidox Productions will again produce the Top 50 video report for the luncheon. Table sponsors include Fire & Safety Systems and Alford, Staples, Lapeyre & Robicheaux.
|Steven Coll
Keynote speaker will be Steven Coll, a two-time winner of The Pulitzer Prize, current president of the non-partisan New America Foundation and a staff writer for The New Yorker magazine. Coll previously spent 25 years at The Washington Post, where his roles included foreign correspondent, senior editor and managing editor. He won his first Pulitzer (with David A. Vise) in 1990 for an account of the SEC's battle with Wall Street (later published as a book Eagle on the Street). Coll was awarded a second Pulitzer in 2005 for his book Ghost Wars: The Secret History of the CIA, which received three additional prestigious awards for coverage of international affairs. In May, Coll published the most recent of his seven books: Private Empire: Exxon Mobil and American Power. Critics at BusinessWeek, The Washington Post and USA Today-Money describe Coll as one of the few journalists in the world who could tackle such a daunting topic and laude his impartiality in telling the tale. The New York Times calls Coll's work "meticulous, even-handed and valuable." Last month he announced that that he will transition into a Senior Fellow role at The New America Foundation to pen a follow up to Ghost Wars.
Barnes & Noble will provide books for sale and signing at the event.
Tickets are $50 per person or $450 for a reserved table for eight.
For more information or to download a ticket order form online, go to www.theind.com/indevents or contact Robin Hebert at 337.769.8603 by phone
or by email at firstname.lastname@example.com


text:
Back To The Great Warming.com
Climate Change Fact Sheet
The Scientific Consensus on Climate Change
What individuals can do!
Do something about Global Warming
Join our allies and support their local and national efforts
to curb global warming
Energy Star Action Guide
Global warming solutions through community dialogue!
How to Talk to a Climate Skeptic
We can all make a difference – by changing our behavior, by urging our leaders to act, and by endorsing
and using the products of environmentally-responsible companies like our sponsors. Find out more about them here.


text:
You must earn 10,000 points to post other members' whiteboard
You may be interested in calculating / viewing / comparing electric costs here at: http://michaelbluejay.com/electricity/cost.html
May our dependence on oil continue to decline. Happy Holidays to you & yours!
Thanks for becoming my newest buddy, especially from Prince Edward Island! I do appreciate all GasBuddies throughout the USA and Canada! Have a nice weekend! Ron
ROFL; Just between you and me, some people are right all the time. ;/)
Would you be interested in: a new one with twist in rules: Counting backwards from 100-0 by 2's. SAME one post-per person-per day. The TWIST is when the game is done and a new game starts everyone also starts again following the one post-per person-per day. Remember it is a game so have fun and good luck. See you in the winners circle. Ed. http://www.winnipeggasprices.com/Forum_MSG.aspx?master=&category=1235&topic=589810&page_no=1&FAV=Y
To satisfy your curiosity as to why your story was removed you can find the answer here:
Now you see it, now you don't...went to comment & it was gone...
Oops. Posted a blank.
I just saw the article you posted, and as I was reading the article, they took your article down. Do they send a message to tell you why?
Write to orphancarguyPE's whiteboard
Just had a news story I posted wiped away in less than an hour -- a Daily News clip about the Rosebud Sioux calling the House vote on Keystone XL an act of war. Interesting a news story gets nuked, but the mod still lets commentary from a number of debunked sources stay alive forever.


text: Tutor Notes – private teacher assistant is an app that focuses specifically on a private teacher's needs, making it quick and easy to navigate through. With one tap teachers can open new lesson cards, save current cards, view previous lesson cards and student's contact details, and much more. Tutor Notes says it gets straight to the point to save time and keep things as easygoing as possible.


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You have to convince them they do. I thought advertising was a dirty word and promotion was something that only sellouts (in the bad sense) worried about.
Then I produced my first show with my own money. Lesson learned.
From a producer's standpoint, the Fringe is a dream because costs are low, but also because there is a huge potential audience. Potential. Because while there are thousand of people who go to the Fringe anxious to gorge on theater for a week and a half, stuffing themselves with dance, improv, comedy, kid's shows, monologues, anything, anything, ANYTHING they do have one, from the artist's standpoint, one critical flaw. They want it to be good (Bastards!).
And I'm the same way. I don't care if your Fringe show is your life's work, the honest expression of your soul. Am I going to be entertained? Is it going to be worth 45-60 minutes of my life when I could be sitting at another venue? What's in it for me?
So here's how you convince me to come see your show:
This is the single most important part of your advertising. This is a big freaking fish hook that can spear an audience member and reel them in. You can tell a good title to someone without any other description and have them see the show in their head instantly. I'll give you an example from a previous year: Kung Fu Hamlet. I hear that title and know instantly that I have to see it.
On the opposite end, there are two kinds of bad title. The boring and generic (e.g. My Wacky Ethnic Family!, Relationships! They're Crazy!) and titles that let you know the show is just going to be Hell on the audience. On a long car trip my wife and I played a game where we tried to come up with the worst Fringe title imaginable. I thought I came up with some good 'uns with Have You Ever Really Looked at a Leaf? and Can I Play This Banjo? but of course my wife trumped them all with My Plantation of Hope, which is so gloriously awful, laying there like a marble turd. And you just know it's the last line of the play, too; "And I knew that it was now my plantation... my plantation of hope."
The show title tells you everything you need to know about the show, and the producer, in just a few words.
This is the second biggest thing that will draw me to a show, or let me know that I should skip it. Whether at a Fringe For All or the online trailers, this gives me a taste for a show and lets me, for the first time, see how good the actual performance might be. I say "might" because it is possible to give away the best three minutes (or the only good three minutes) of your show to get me in the door, but as an audience member, that's the risk you take. There were several shows that I might have ignored had I not gotten a taste at the Fringe For All: The First Five Minutes Are Slow (which told me nothing about the show's story but was so visually arresting) and the trailer for Rachel Teagle Believes in Ghosts which, while the video wasn't that great, let me know how good her storytelling ability is.
Word of Mouth
"So what have you seen?" About 36 hours in to the Fringe there will start to be a consensus on what's good. People can game the online reviews, creating new identities and getting their family to post five kitty reviews, but it's a lot harder to lie to someone's face at Fringe Central, especially when they're drinking with the cast of the show they're pimping. And while not everyone wants to sit and type out a review, anybody with a Summit in their hand will tell you their opinion of a show.
It's been a while since I've gone to see a show because they had a great postcard. Back in the day, a glossy four-color print said something about the amount of money (and, indirectly the professionalism) a company was putting into a show, but now the cost has come down so much that it's practically required. It's now a measure of how good your graphic designer is. But postcards are vital as the second stage: people stuff them in their pocket, pull it out at the end of the day and it reminds them to ask about it, look online, find out more.
It's easy to have a bad photo. It's easy to have a well-shot photo. It's hard to have a great photo, one that, like a title, expresses the idea of the show with a kick to the eyeball. Zombie High School (which is also a good title) nails this: because not only does it have a well-shot photo of young man with horrible wounds (visually arresting, even on a table full of other cards), he's smiling, which throws me for a loop and makes me look at the title, and at this point I'm hooked. Because the photo, along with the title, tells me that the people putting this show together probably know what they're doing.
This is actually the biggest reason I go to see a show: because I know someone who's in it, and like I say it's hard to lie to someone's face about how good a bad show was, but it's even harder to lie about how good a show you didn't even watch was. I, of course, don't have this problem because all my friends are ridiculously talented and fabulous and I doubt I could take any of them in a drunken fist fight in the Bedlam parking lot.
So this is the list of why I might go to see a show, which does no one any good this year because everything they can control has been locked down for weeks, and word-of-mouth is out of their hands. Huh. So, while being completely useless, it gives you some idea of where I'm coming from.
Next up, a look at some of the shows that have hooked me in, including with one which has a bad title but a great preview, and the two parts of a show's promotion you can ignore.


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One of the best (not best) jokes I've ever read on Twitter was when someone, apropos of nothing, tweeted: "So when are we ever going to find out how he met their mother?" LOL. LOOOOOOOOOL. What I liked about it was how it was like everyone was thinking it, but this guy was the only one who said it. Haha, ugh. Ugh to me. The amount that I think about and hate that tweet is definitely wrong and I don't remember who tweeted it but I'm sorry if it was you. But the point I'm getting to is that I didn't realize that meeting the mom on that show was a real thing? I've never seen it, which is my first problem, but I thought that was just the name. It turns out it's also the frame story! You learn something new that I'm sure everyone else knows every day. Anyway, in a panel discussion at the Television Critics Association co-creator Carter Bays revealed that the show — currently in its 7th season — may not conclude for a while. From Deadline:
We totally might want to go beyond Season 8. Obviously, it won't just be our call. It will also be about what our actors want and of course what CBS wants. But right now the network is delighted with the numbers we're getting. If everyone's game to go beyond Season 8, it will be a matter of how much story is left. We have that big ending planned, and we know how we need to get the characters in place to make it there.
Aarrrrggggh, BUT WE NEED TO KNOW HOW HE MET THE MOTHER! Is there any HIMYM ending speculative fan fiction out there? Have you guys ever written any for yourselves? I know I somehow just heard about this now, but knowing that there IS an ending already planned I really can't wait until like 2015 to find out. Did he meet her through a mutual friend? Did they go to college together? Were they both late for a flight? GUYS! WHAT'S THE DEAL WITH THIS SHOW? WHY CAN'T THEY JUST TELL US?! (Via Pajiba)
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"Seasons 9 and 10 are definitely my favorite." – nobody about anything, ever
plus Ted always refers to her as "your aunt Robin" when he's talking to the kids.
He met her through the adoption agency, but the contract clearly stated that only she could decide if she wanted the children to know her identity.
They haven't even done the time travel season yet, so yeah, we've got a ways to go.
I think they met on HOT or NOT.
The thing is: Nobody cares anymore. People stopped caring when the show turned into Barney's Bimbo Bingo around season five or so.
i dont get why people are surprised or pissed about this. don't they realize the end-game isn't necessarily the point?
The name of this show is "How I Met You Mother?" I thought it was "How I Met You Otter," and I've been waiting eight years for the show to make even one otter joke. Thank god, I thought I was going mad.
Who cares? Ted is the worst.
"It's basically Friends 2.0 now." A horrible thing to say about any show. But chances are pretty much 100% it'll end up as a blurb on the cover of the next DVD release of this show.
I read your comment with Charlie Brown's voice in my head and I'm still chuckling.
Not only has it taken his dad 8 years to tell a story that should've take 2 minutes, but his parents are already divorced by now…
When are we going to find out if Chelsea is there?
It's been 7 years and Ted still hasn't begun to sound like Bob Saget yet.
The way the series should end is in the last 30 seconds of the last episode, he is just standing next to a lady waiting for the bus and he says, hi how's it going? And then it ends.
Nailed it.
And then the sound of a gunshot.
SPOILER ALERT: Marshall dies (very, very sad) and then Ted marries WillowLily and raises their kids. The last moment of the series turns the camera from the kids to Bob Saget where he says, "I'm not your father."
Hahahaa drewgaze
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|Writing Resources
|World Flags Project
|Working Remotely - What You Need to Know
|Witold F. Krajewski
|Wireless Network in SC
|WinRAR to Extract and Compress Files
|Windows Security Patches
|Windows Patching Policy
|Wind Energy Working Group
|Wind Energy Training and Education
|Wind Energy Resources
|Wind Energy Research
|Wind Energy Employer Services
|Wind Energy Corporate/Community Partners
|Wind Energy Contact
|Wind Energy Competitive Advantages
|Wind Energy Collaborative Projects
|William Jennings
|William Easton
|William E. Eichinger
|William D. Ashton Professorship in Civil Engineering
|William D. Ashton
|Wilfrid A. Nixon
|Why Visit The Hanson Center for Technical Communication?
|What We Do
|What Makes the College of Engineering Unique?
|What is Ethnic Inclusion?
|What Goes on in the Engineering Electronics Shop?
|Wendy D Brentner
|Welcome to the ECE Survey page
|Welcome to Academic Information & Forms
|Welcome from the DEO (MIE)
|Welcome from the DEO
|Welcome Back to the College Reception
|Welcome (ECE)
|Weiyu Xu
|Webmail: Purge Deleted Mail
|Webmail: Filtering Email
|Webmail - How to Use
|Web Page Tools
|We are sorry
|Ways to Support
|Wayne Paulson
|Wayne L. Paulson
|Waiving of Mechanical Engineering (ME) Seminars


text:
2 people found this helpful
"The best option for an airline job, if you're crazy enough to get an airline job "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at JetBlue
Great benefits, (insurance, free flights for you and family, 401k, 100 percent matching up to 8 percent of pay),
Better pay than other airlines,
Being a flight attendant is pretty cool,
Job security (they don't do layoffs, just buyouts),
Being a flight attendant is also really stressful,
The uniforms suck,
The life of a reserve flight attendant at JetBlue is way harder than other airlines,
Huge difference in quality of supervisors, some are great, some are horrible.
More consistent training for supervisors, make sure they have inflight experience.
Better, non-polyester uniforms, fewer minimum rest layovers.
Send all Embraers back to the factory.
308 Other Employee Reviews for JetBlue (View Most Recent)Sort: Rating Date
"A fun company with limited opportunities "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at JetBluePros
Flight Benefits, Work/Life Balance, interesting industry, innovative at timesCons
a very competitive industry known for poor management, mergers, and unions
a lot of politics
some people get put in jobs that they don't know have experience in
professionalism is questionable with some peopleAdvice to ManagementAdvice
Keep striving to be innovative and implement a training program to develop talent to move into other areas of company.RecommendsApproves of CEO
1 person found this helpful
"Great company, unless it's IT. "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at JetBluePros
Rapid growth fuels lots of work and constant challenges. If you're looking for excitement, airlines have plenty and JetBlue is one of the best. I would recommend working at JetBlue as long as you are not considering IT.Cons
I would not recommend working for the JetBlue IT department under the current senior leadership. Fear and intimidation are not leadership skills. Critique publicly and compliment never is also unacceptable. Additionally, even herculean achievement will not result in career advancement despite the definite challenge IT Crewmembers have with work life balance given workload and staffing. The company overall has had a very difficult time with performance management and IT has been at the head.Advice to ManagementAdvice
Judge leadership on their organization's Net Promoter Score. NPS says it all. If you're not listening to it you're either not listening to your people or not treating IT like the rest of the company.Doesn't RecommendDisapproves of CEO


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After I read the first three sentences, I wanted to delete this assignment. However, my feelings about the genre should not hinder me from reading further.
Like fleas jumping erratically on a dog after it were sprayed with flea treatment, The End was confusing and hard to follow. I will not blame your grammatically errors for my lack of understanding, my lack of understanding rears its head from the simple fact- the plot or story line was not clear. One problem with your story line was the transition between different scenes. The asterisk * as a symbol for transition needs to be abolished, eliminated, destroyed, as a writer you must take the time to find a better and smoother way to make transitions.
Another confusing part of your short story was the Japanese, why are they in the story. It appears the story setting is outer space. I have this strange feeling that you use Microsoft grammar and spell check in rush. (Ive done that myself. It was a huge mistake.)
Review of: The End
reviewed by dreamtowrite on 02/03/2011
Credited Review
Review ID: 3620328
Other Reviews by dreamtowrite 22
A review of Glassby dreamtowrite on 11/28/2011I enjoy the idea of the short story, but unfortunately it does not reach its true potential. Because you did not spend enough time developing your characters and storyline. I don't know who is the main character, Henry, Marla, or the young mother. Or Maybe the main character is the mirror who shows the people innerself. I would love to see you expand on your idea because I... read
A review of Malevolenceby dreamtowrite on 04/21/2011I really, really, really love your short story. Your story held my attention from start to finish. I didn't want it to end. The suspense. The mystery. Pull me in. The ending it surprise the heck out of me. Just wow. Every last one of your character fit in the short story. I never ask myself why is that person in this story. Your characters had life and meaning. None of them... read
A review of Dr. Tower's Babelby dreamtowrite on 02/01/2011Your short story held my attention. However, I do not remember the main character's name. Despite my lack of memory, I must admit that your idea that Science and God are one in the same was quite intriguing. This review is not a debate on whether I agree with you or not. I won't do that to you. The reading level of your short story is college-level perhaps high school honors... read


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The next time you talk with your publisher, you might want to ask about what tools you can use to improve your author website.
See, your publisher is in the business of selling books and the web is an increasingly important marketing tool for any author or publisher. Many publishers are quickly becoming acquainted with what works – and what doesn't – when it comes to selling books online.
Micheal Hyatt was until recently, the Chairman of Thomas Nelson Publishers, the largest Christian publishing company in the world and the seventh largest trade book publishing company in the U.S. Just prior to a meeting with one of his biggest authors – he decided to run the author's website through a few online tools he had found which take a look "under the hood" of any website. In his blog post 4 surprising conclusions about author websites he writes:
I was reminded again how many authors think that by just hanging a website in cyberspace they are somehow building their brand. As it turns out, not so much.
This blog post is 2 years old and a few of the SPECIFICS in this article are outdated but the basis for his argument remains the same today as it was then.
For example, his first observation about author websites is "Having a really slick, graphically-clever website does not necessarily correlate with more traffic" use to be true all the time but now it's not some of the time today.
It's always been true that the most visually attractive websites are designed using flash. It wasn't so long ago that most websites designed with flash were virtually invisible to the search engines. Back in those days – having a beautiful website often meant sacrificing search engine visibility.
Fortunately, those are the "not so good old days" when it comes to author web design. Today – you can create a stunning, beautiful flash website that is search engine friendly
– and by using this link you can do it for free.
Hyatt's other observations help to prove a singular point – the best author websites are the ones that are search engine friendly!
If you thought a nationally aired television or radio program would help your author website's performance – think again. Hyatt found that one of the authors with the biggest media platforms was dead last during his research.
Think having a large organization behind you will help? Think again – some authors with large organizations were near the top while others were near the bottom.
In the end- the tool Hyatt shares with readers simply measures the ability of the search engines to index a particular author's website. As a publisher, he wants his authors to form a strong internet presence and build their brand online. Building an author website that can be found by the search engines is an essential part of building that brand- and ultimately selling more books.
Micheal Hyatt ends his blog post with this word of encouragement:
The good news is that it is not that difficult for authors to build a powerful, online presence. Nor does it cost much.
Today – you can not only build your great author website for free – you can build one that looks like you paid tens of thousands of dollars to have it designed!


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Internet Satellite TV Player 1.2
Internet Satellite TV Player offers access to more than 1300 channels and it does not require a PCI card or a satellite dish. The only pre-requisite is Internet access, seeing as it establishes connections with various servers in order to stream the channels.
Clear-cut interface
Internet Satellite TV Player features a very straight-forward user interface, with all the options in plain view. On the left side of the main window, a list of countries is displayed with the available broadcast channels, while the right panel is reserved for viewing purposes.
As a result, it becomes quite clear that all types of users can find their way around it, without encountering any issues.
Look for a channel and control assigned bandwidth
A real-time search function in Internet Satellite TV Player lets you easily find a specific channel. Just below, there is a section that deals with the settings of the application.
To be more accurate, you can adjust two major options for channels before selecting them: bandwidth quality and buffering time (from 1 to 60 seconds).
Watch a TV channel, pause the stream and add it to Favorites
Videos can be toggled to full screen mode, and also added to the Favorites folder. Most of the channels work, although we could not spot the difference in the quality of the image, whether we selected the lowest bandwidth or the highest quality.
Information such as station name, bandwidth and description is available in the main window, while it is also possible to adjust the stream's volume, as well as play, pause or stop it with the built-in controls.
To sum it all up, Internet Satellite TV Player is a breath of fresh air in its software category. The list of channels is updated twice a week and every time, the channel list grows with about 25 items. It is simple enough to appeal to all user categories and it is not pretentious requirement-wise.
Reviewed by Elena Opris, last updated on July 14th, 2014
- file size:
- price:
- $14.95
- license type:
- Demo
- developed by:
- Chama Digital Media
- operating system(s):
- Windows All
- category:
- C: \ Internet \ Internet Radio/TV Player
- download hub:
- Play Online TV
In a hurry? Add it to your Download Basket!
- New Interface
- Supports flash video playback
- Bugs fixed
Application descriptionInternet Satellite TV Player will allow you to watch more than 1300 TV channels worldwide, FREE, wherever you are, onl...


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microRNA Prognostic Marker Identified in Acute Leukemia
Distinguished University Professor, the William Greenville Pace III Endowed Chair in Cancer Research, and cancer scholar/senior adviser to the OSUCCC – James
A study led by researchers at The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC – James) has identified microRNA-3151 as an independent prognostic marker in certain patients with acute leukemia.
The study involved patients with acute myeloid leukemia and normal-looking chromosomes (CN-AML). It found that when microRNA-3151 (miR-3151) is overexpressed in CN-AML, the disease responds poorly to treatment, and patients experience shorter remissions and survival periods.
This effect is independent of other gene mutations that may be present. Additionally, miR-3151 is encoded within a gene called BAALC, which itself is an independent marker of poor survival when overexpressed in CN-AML.
The findings provide insight into the nature of AML and might help determine the best therapy for individual patients, further personalizing AML therapy.
"Patients with high levels of both miR-3151 and BAALC had the poorest outcome compared with those showing high expression of
either miR-3151 or BAALC alone, or those expressing low levels of both," says principal investigator Clara D. Bloomfield, MD, a Distinguished University Professor and cancer scholar/senior adviser to the OSUCCC – James. "This suggests that miR-3151 and BAALC may act through different mechanisms to enhance poor outcome of CN-AML patients."
The study involved 179 patients of age 60 or older with CN-AML who were treated on Cancer and Leukemia Group B (CALGB) clinical trials.
MicroRNAs are small molecules that cells use to help regulate the kind and amount of proteins they make. About a third of human microRNAs are encoded within host gene sectors called introns, short stretches of DNA that are not used when genetic information is translated to make a protein.
First author Ann-Kathrin Eisfeld, MD, a postdoctoral researcher in the laboratory of study co-author Albert de la Chapelle, MD, PhD, and Bloomfield, says this study provides "the first description of interplay of an oncogene and its intronic, and possibly oncogenic, microRNA."
Published in the Journal Blood
professor and chair of the Department of Radiation Oncology, co-director of the Brain Tumor Program at the OSUCCC – James and the Max Morehouse Chair in Cancer Research
Radiation oncology researchers have revised the system used by doctors since the 1990s to determine the prognosis of people with glioblastoma, the most devastating of malignant brain tumors.
The outdated system, which was devised for glioblastoma and related brain tumors that were treated by radiation therapy only, relied on clinical signs and symptoms, and it divided patients into six prognostic groups. The new system accommodates advances in treatment, particularly the use of radiation therapy plus the chemotherapy drug temozolomide, and incorporates molecular biomarkers as well as clinical variables.
"The new model is more relevant and contemporary, and it should do a better job of identifying patients who require the most aggressive therapy," says Arnab Chakravarti, MD, the study's chair for translational research.
Chakravarti, professor and chair of the Department of Radiation Oncology at Ohio State and co-director of the Brain Tumor Program at the OSUCCC – James, presented study findings at the 2012 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
To devise the new system, Chakravarti and colleagues compared tumor and healthy tissue from 162 glioblastoma patients who were treated under the Radiation Oncology Group clinical trial 0525 (RTOG 0525). The investigators profiled protein, messenger RNA and epigenetic changes in patients' tumor cells while looking for alterations in key signaling molecules.
They showed that high expression of the proteins pAKT, c-met and MGMT was associated with poor prognosis, while methylation of the MGMT gene, which codes for a DNA repair protein, was associated with a better prognosis.
"We hope to begin further studies to validate our classification system soon," Chakravarti says.
To refer a patient, please call The James Line New Patient Referral Center toll free: 1-800-293-5066.
Inherited DNA Alteration Explains Overactive Leukemia Gene
MD, PhD,
co-leader of the Molecular Biology
and Cancer Genetics Program and the
Leonard J. Immke, Jr. and Charlotte L.
Immke Chair in Cancer Research Fund
A new study shows that a small inherited change in DNA is largely responsible for overactivating a gene linked to poor treatment response in people with acute leukemia.
The study, led by researchers at the OSUCCC – James, focused on the BAALC gene, which is often overexpressed in acute myeloid or acute lymphoblastic leukemia. This work indicates that these diseases
will likely respond poorly to standard therapy.
Researchers discovered that BAALC overexpression is caused by a small change called a single nucleotide polymorphism (SNP) in the gene's DNA. The SNP alters the gene's "on" switch, allowing a different molecule to keep it "running" when it shouldn't.
"This SNP doesn't raise risk of developing leukemia, but it predisposes to overexpression of the BAALC gene, which is associated with leukemia development and poor response to treatment," says principal
investigator Albert de la Chapelle, MD, PhD, co-leader of the Molecular Biology and Cancer Genetics Program at the OSUCCC– James.
The findings suggest this SNP could be a useful prognosis marker and help guide therapy in acute leukemia patients.
Researchers say the DNA change caused by the SNP creates a binding site for an activating molecule called RUNX1, which is also involved in forming normal and malignant blood cells. The scientists showed that patients with high levels of RUNX1 protein also had high BAALC expression, while those with low RUNX1 protein had low BAALC gene expression.
For this study, de la Chapelle and colleagues used DNA sequencing to examine the genomic region of BAALC in 253 patients with cytogentically normal AML treated in Cancer and Leukemia Group B clinical trials. The analysis revealed nine SNPs of interest, but the researchers focused only on one called rs62527607[T].
"We doubt that this SNP is entirely responsible for BAALC overexpression, but we believe it is a major contributor," de la Chapelle says.
Published in Proceedings of the National Academy of Sciences.
Supported in part by NIH/National Cancer
Institute grants CA098933, CA101140,
CA33601, CA16058, CA77658, and
Marker Distinguishes Aggressive Form of Chronic Leukemia
director of the Division of Hematology; professor of Medicine, of Medicinal Chemistry and of Veterinary Biosciences; and the D. Warren Brown Designated Chair in Leukemia Research
Researchers have identified a prognostic marker in the most common form of chronic leukemia that can help distinguish patients who should start treatment quickly from those who can safely delay treatment, perhaps for years.
The study, led by researchers at the OSUCCC – James, focused on chronic lymphocytic leukemia (CLL). Examining a gene called ZAP-70 in CLL cells for a chemical change called methylation, they found that, when this gene in leukemia cells is methylated, patients are likely to have the slowprogressing form of CLL. When the ZAP-70 gene is unmethylated, patients are likely to have aggressive disease and should consider immediate treatment.
Currently, doctors must simply observe newly diagnosed patients to determine which type of CLL they have. This can delay the start of treatment in patients with aggressive disease, or it can lead to treating patients who don't yet require it.
"This study demonstrates that ZAP-70 methylation status is a highly predictive, reproducible biomarker of poor prognosis in this disease, and a clinically useful prognostic test for CLL," says principal investigator John C. Byrd, MD, a CLL specialist who directs the Division of Hematology at Ohio State.
The presence of mutations in a gene called IGVH and the amount of protein produced by the ZAP-70 gene in CLL cells are sometimes used to predict prognosis and response to treatment in people with this disease, "but these assays are expensive and difficult to perform," says study co-author and researcher David Lucas, PhD.
"In all cells, some areas of DNA undergo methylation, which controls how that DNA is used," Lucas says. "In cancer cells, the pattern of DNA methylation is often different from that of healthy cells, and this influences how much protein is produced by ZAP-70 and other genes."
Published in the Journal of Clinical Oncology
microRNA Loss May Power Malignant Transformation in CLL
director of Human Cancer Genetics and the John W. Wolfe Chair in
Human Cancer Genetics
Loss of a particular microRNA in chronic lymphocytic leukemia shuts down normal cell metabolism and turns up alternative mechanisms that enable cancer cells to produce the energy and build the molecules they need to proliferate and invade neighboring tissue.
The findings come from a study led by researchers at the OSUCCC – James, who showed that microRNA-125b (miR-125b) by itself regulates many enzymes and other molecules that allow cells to make building blocks for their growth and proliferation, such as DNA and lipids needed for cell membranes.
The study also showed that miR-125b is often lost in chronic lymphocytic leukemia (CLL), and that the loss is associated with higher rates of glucose metabolism. This is a characteristic of cancer cells called the Warburg effect, and it alters how cancer cells use glucose to generate energy. This finding suggests that loss of miR-125b is an early step in CLL development.
The researchers say the study provides a more comprehensive understanding of how cancer develops and identifies potential targets for CLL drug development.
"Our findings indicate that miR-125b is downregulated in both aggressive and indolent forms of CLL, and that this downregulation is associated with metabolic adaptation to cancer transformation," says principal investigator and corresponding author Carlo Croce, MD, director of Human Cancer Genetics at Ohio State and a member of the OSUCCC – James Molecular Biology and Cancer Genetics Program.
"By identifying the metabolites that are changed, as we have here, we can propose to use drugs that target them and perhaps control the leukemia," Croce says.
Scientists have known for some time that, as normal cells become cancerous, different metabolic pathways are switched on and support the enhanced growth and energy needs of malignant cells. This study reveals one way that can happen.
Published in the journal Blood.
People With Allergies May Have Lower Risk of Brain Tumors
JUDITH SCHWARTZBAUM, PhD,
a member of the OSUCCC – James Cancer Control Program and the study's lead author
An Ohio State University study adds to growing evidence that links allergies and reduced risk of a type of brain cancer. The study suggests the reduced risk is stronger among women than men, but men with certain allergy profiles also have a lower tumor risk.
Because these tumors, called gliomas, can suppress the immune system to allow themselves to grow, researchers have never been sure whether allergies reduce cancer risk or if, before diagnosis, these tumors interfere with the hypersensitive immune response to allergens.
In this study, scientists analyzed stored blood samples taken from patients decades before they were diagnosed with glioma. Men and women whose blood samples contained allergy-related antibodies had an almost 50-percent lower risk of developing glioma 20 years later compared with people without signs of allergies.
"This is our most important finding," says Judith Schwartzbaum, PhD, a member of the OSUCCC – James Cancer Control Program and the study's lead author. "The longer before glioma diagnosis that the effect of allergies is present, the less likely it is that the tumor is suppressing allergies."
The researchers analyzed stored blood samples from 594 people in Norway who were diagnosed with glioma (including 374 with glioblastoma) from 1974-2007, then compared them – for date of blood collection, age and sex – with 1,177 samples from people not diagnosed with glioma.
They next measured levels of two types of proteins called IgE, or immunoglobulin E – antibodies produced by white blood cells that mediate immune responses to allergens. In each sample, they determined whether the serum contained elevated levels of IgE specific to common allergens in Norway, as well as total IgE.
Among women, testing positive for elevated allergen-specific IgE was associated with a 54-percent decreased risk of glioblastoma compared with women who tested negative for allergen-specific IgE. The researchers did not see this association in men.
"There is definitely a difference in the effect of allergen-specific IgE between men and women," Schwartzbaum says.
Published in the Journal of the National Cancer Institute
Download the print issue here.
The Ohio State University300 W. 10th Ave. Columbus, Ohio 43210
© The Ohio State University


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US/Canada (Toll Free): 1 877 772 6672
UK (Toll Free): 0800 731 5567
Spain: + 34 615932620
Home / Southern Charms
Classic Kerala Tour with Backwaters and Luxury Houseboats Trip of Kerala
Duration: 10 DaysBreathtaking vistas, idyllic hills, serene beaches and rich backwaters make up the tropical landscape of Kerala. Enjoy misty mornings in the sleepy plantation town of Munnar, lazy afternoons in the privacy of the backwaters of Kerala, adventurous evenings in the company of enchanting wildlife in Periyar and romantic nights in the solitude of Mararikulam. Kerala, also known as God's own country, holds in its heart tales of eras gone by and precious moments to be uncovered by the avid traveler.
Destinations: Cochin / Munnar / Thekkady / Kumarakom / Alleppey / Mararikulam / Cochin
Destinations: Cochin / Munnar / Thekkady / Kumarakom / Alleppey / Mararikulam / Cochin
Day 1-2: Cochin
Day 3-4: Munnar
Day 5-6: Periyar
Day 7: Houseboat
Day 8-9: Mararikulam
Day 10: Back Home
- Farewell dinner,
- Mobile phone during your tour,
- Harbour cruise in cochin,
- Kathakali dance presentation in cochin,
- Visit to tea estate in munnar,
- Day package at periyar with bamboo rafting,
- All meals in the houseboat,
- Unlimited mineral water and tissues during drives and
- Dedicated tour manager / coordinator for tour.
© Compass Tours. -'A Holding of Compass India Holidays Pvt. Ltd.'.All Rights Reserved


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Mad Men
Cannes Film Festival 2014: Robert Pattinson & Kristen Stewart Movies Make the Lineup
Originally posted 04/17/2014 01:25PM
Robert Pattinson and Kristen Stewart could end up in very close proximity next month.
The exes are among the scores of stars slated to attend the famed Cannes Film Festival, which runs from May 14 to 25 and revealed its lineup in a press conference Thursday.
Pattinson, 27, has two films in contention: The Rover, a gritty drama set in a near-future Australia, and Maps to the Stars, a Hollywood-skewering drama costarring Julianne Moore and John Cusack. Stewart, 24, will be seen in the drama Clouds of Sils Maria with Juliette Binoche.
Christina Hendricks & Geoffrey Arend's Date Night with Michael Cera
Originally posted 07/12/2013 08:10AM
Christina Hendricks and hubby Geoffrey Arend were the picture of a happy couple on Tuesday night.
The Mad Men starlet and Body of Proof star were joined by a big group of friends, including Michael Cera, at Stone Rose lounge in New York City.
"They were acting cute and she was giggling," an onlooker tells PEOPLE of the pair. "It was adorable how Geoffrey was being sweet with her and totally doting. I was surprised Michael was with them, but they must know each other well because it seemed like they were close."
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