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Wednesday, January 29. 2014
There's a good piece by Jim Davies called 'Academic Obfuscations: The Psychological Attraction of Postmodern Nonsense' which you can read at the Skeptic Society's Lectures site.
Davies discusses why people read obscure passages in academic articles that make little if any sense. In essence, his answer is that because readers have to work hard to extract meaning from the obscurity they value the meaning they think they have found all the more.
I'm sure this is correct. And the unfortunate corollary is that writing that is clear and easy to understand is less likely to gain acceptance for ideas that the reader doesn't agree with already.
Still, I remain an advocate of clear writing. In this I agree with the late F.L. Lucas, whose book Style has been my guide for how to write for many years. Lucas valued clarity above everything else and was scornful of writers who sought to dazzle their readers with pseudo-profundity. Here are a few quotes from his book.
Posted by Anthony Campbell in sceptical stuff at 10:34 | Comments (0) | Trackbacks (0)
Sunday, April 21. 2013
Book review: Paleofantasy, by Marlene Zuk
There is a widespread belief that many of our modern ills, physical and mental, result from a mismatch between our genes and the artificial environment that we have created for ourselves. Books, magazine articles, TV programmes, and numerous websites popularise the view that we were shaped over many thousands or millions of years to live a hunter-gatherer existence in small groups, yet now we live in huge cities with millions of inhabitants. In this 'unnatural' environment we encounter an abundant supply of food and drink of kinds that we are not evolutionarily adapted for. A critical point in our path to all this was the adoption of agriculture a 'mere' ten thousand years or so ago. The path to salvation lies in returning to the habits and diets of our palaeolithic ancestors.
This is an intuitively appealing story, but is it true? According to Marlene Zuk many of the assumptions on which it is based are questionable. While not rejecting the importance of evolution in shaping us - quite the opposite - Zuk picks the presuppositions of the 'paleofantasists' to pieces and shows how ill-founded many of their ideas are. In me, this prompted the thought that the current enthusiasm for life in the palaeolithic really a modern version of the myth of the Noble Savage or a secular version of the legend of the Garden of Eden. [More]
Posted by Anthony Campbell in books, sceptical stuff at 11:03 | Comments (0) | Trackbacks (0)
Saturday, December 29. 2012
Precognitive dream?
Opening today's Independent I read an article about a surf-boarder in Australia who had two fingers bitten off by a shark. I then remembered that last night I had dreamt of a man who had his nose bitten off by a shark.
There have been numerous claims for precognition in dreams. Mine would appear to be an example and I have had similar dreams in the past. But are they really precognitive? The usual counter-argument is that millions of people in Britain dream every night and by chance there will sometimes be some dreams that coincide with events. I think this must be the right explanation.
At a more trivial level, I sometimes have the radio on when I'm at the computer, and from time to time I find myself typing a word at the exact moment I hear the same word spoken on the radio. Sometimes this has been a very unusual word. These coinidences are obviously just that - concidences - and I think the same must be true of apparently precognitive dreams.
We find this difficult to accept because we tend to attach significance to dreams, even if we are not Jungians. For many dreams, like this one, there has been no identifiable precipitating event in the previous day and this makes the coincidence seem more spooky. But if I could identify some trigger for the dream in something I had experienced or read during the day, the spookiness would largely disappear. Such a trigger presumably does exist; it's just that I don't know what it is.
Posted by Anthony Campbell in sceptical stuff at 12:28 | Comments (2) | Trackbacks (0)
Friday, December 28. 2012
Telomeres - the latest "scientific"(?) way to tell your fortune
Today's Independent has a piece about having your telomeres measured. These sequences at the ends of chromosomes are alleged to give an indication of how far your biological age differs from your chonological age. The longer they are, the longer you are likely to live. The test is now available commercially; it's still expensive but is forecast to become increasingly cheaper in coming years, to the point where everyone will be able to afford it.
The one prediction I'm prepared to make is that it will be a money-spinner for the Spanish company that markets it. Professor Carol Greider, who won a Nobel Prize for her work on telomeres in 2009, is sceptical about the value of the test but that won't prevent many thousand or millions of people from taking it. Another egregious example of useless screening. Plenty more about this in my blog - search for "screening" with the search button on the right for links.
Posted by Anthony Campbell in medical, sceptical stuff at 12:09 | Comments (0) | Trackbacks (0)
Wednesday, December 19. 2012
Looking forward to the end of the world (Mayan calendar)
I'm looking forward with pleasurable anticipation to next Friday, 21 December, to see how people who believe that the world will end then, courtesy of the Mayan calendar, will react when nothing happens. Judging by historical precedents offered by previous unfulfilled predictions of the kind, few believers will admit to having been fooled and ways of reconciling fact and faith will be found.
Posted by Anthony Campbell in sceptical stuff at 07:58 | Comments (0) | Trackbacks (0)
Friday, December 14. 2012
Scepticism, homeopathy, and the Swiss Government report
For some reason the fact that the Swiss Government had produced a favourable report on homeopathy had escaped my notice until today, but when I learnt of it I looked it up on the net. This brought me to the Quackometer site, which has a discussion of the report called The Swizz report on homeopathy.
Well, of course, you'd expect the Quackometer to be critical of a report that supports homeopathy, but fortunately their piece contains some quotations from the Swiss article which help us to make up our own minds..
This passage is a complete give-away, particularly the reference to spiritual science. This will no doubt puzzle many readers, but anyone who knows anything about Anthroposophy, the so-called "Spiritual Science" founded by the philosopher and mystic Rudolf Steiner in the first half of the twentieth century, will recognise the term at once. It seems certain that Anthroposophical influences helped to shape the authors' conclusions.
So Newton is outmoded and a waste of time but science is not a total washout, it seems. Further on, predictably, we are told that homeopathy is supported by quantum physics.
Since few of us who are not trained physicists have any deep understanding of quantum mechanics or relativity we mostly have to rely on non-mathematical descriptions of these things written for readers like us. Some of these are very good, but physicists assure us that verbal accounts cannot give an in-depth understanding of the matter. Quantum mechanics is often invoked to explain the action of highly dilute homeopathic medicines. Often, I think, this amounts to little more than asserting that quantum mechanics and homeopathy are both mysterious, so they ought work in the same way. Moreover, if science can tolerate the paradoxes of quantum mechanics, why baulk at homeopathy?
Just to round off, I should point out that we even get the long-discredited idea of the vital force.
I admit I haven't read the whole of this (long) report and perhaps some parts of it are better. But at least it seems clear that its authors are hostile to the values of the Enlightenment, which is enough to move it a long way down my reading list.
Posted by Anthony Campbell in medical, sceptical stuff at 16:31 | Comment (1) | Trackbacks (0)
Wednesday, October 24. 2012
Getting away with it: Jimmy Savile, Laurens van der Post, and Eric Gill
The current furore over the unmasking of the late Jimmy Savile as a paedophile reminds me of two other once-revered figures who also 'got away with it' by dying before their misdemeanours came to light.
One was Sir Laurens van der Post (1906-96). Storyteller, J.D.F. Jones's biography of this erstwhile guru, informs us that his numerous sexual liasons were conducted with little apparent regard for the feelings of the women concerned. More than once, it seems, an unwanted pregnancy was the signal for Laurens to decamp hurriedly and disappear. But the most startling episode of the kind occurred when, at the age of 43, he seduced and made pregnant a 14-year-old South African girl who had been placed in his care. This event, which would have ruined Laurens if it had become known in his lifetime, was not revealed until after his death.
The other figure was Eric Gill (1882-1940). He was a renowned sculptor and designer, a group of whose sculptures can be seen on the front of BBC Broadcasting House in London. Like Savile, he was a Roman Catholic. He was deeply religious but his personal diaries recount repeated episodes, not merely of paedophilia, but of incest. As his entry in Wikipedia states, 'Gill sexually abused his own children, had an incestuous relationship with his sister and performed sexual acts on his dog. This aspect of Gill's life was little known until publication of the 1989 biography by Fiona MacCarthy. The earlier biography by Robert Speaight mentioned none of it.
The Tibetans, it is said, hold that you should not expect a guru to be a guru all the time. Instead, you should recognise that all gurus are flawed and should try to catch the guru when he is being a guru. This may be true, but these three individuals do seem to have take matters to extremes.
Posted by Anthony Campbell in sceptical stuff at 16:26 | Comments (0) | Trackbacks (0)
Monday, September 12. 2011
Nice iconoclastic article in BMJ
This week's BMJ (10 Sept 2011) has a nice article by Nigel Hawkes expressing doubt about the validity of much of the dietary advice we are so often regaled with.
Hawkes is making the same point as Gary Taubes in The Diet Delusion. Both repay reading by anyone of a sceptical turn of mind.
Posted by Anthony Campbell in medical, sceptical stuff at 16:13 | Comments (0) | Trackbacks (0)
Friday, May 20. 2011
End of the world on my birthday?
An American preacher, Harold Camping of Oakland, California, is predicting the Second Coming and the 'rapture' for tomorrow, 21 May. As this is my birthday I suppose you could say this will be an unexpected birthday present for me, except that, as a non-believer, I don't think I shall be among the two per cent of the population who qualifies for immediate translation to heaven. Oh well ...
Posted by Anthony Campbell in light relief, sceptical stuff at 08:26 | Comments (0) | Trackbacks (0)
Monday, February 7. 2011
Did the ancients know about the precession of the equinoxes?
The "precession of the equinoxes" refers to the slow shift in the Earth's axis of rotation, which produces a gradual change in the positions of the constellations. The axis of rotation of the Earth is wobbling, like a spinning top. A complete revolution of the axis takes approximately 26,000 years. This is known to astrologers as the Platonic Great Year.
I was listening today to the BBC programme Start The Week, in which the astrophysicist Jocelyn Bell Burnell was talking about the current Internet flap concerning a Mayan prophecy of the end of the world on 21 December next year. She did a good job of showing this up as an egregious example of pseudoscience, which of course it is. She is due to give the Faraday Lecture on the subject at the Royal Society.
But she also mentioned that the Mayans, along with a number of other ancient peoples, including the Babylonians and Sumerians, all knew about this 26,000 year cycle. But did they?
According to Gary D. Thompson, whose scholarly website on ancient astronomy is the place to go for information about such questions, the idea of ancient Mesopotamian knowledge of the cycle is a myth. In his extensive discussion, The Myth of Babylonian Knowledge of Precession, he writes:
Wikipedia is equally dismissive of claims for knowledge of precession on the part of the Babylonians and ancient Egyptians, and indeed the Mayans. "There has been speculation that the Mesoamerican Long Count calendar is somehow calibrated against the precession, but this view is not held by professional scholars of Mayan civilization."
Dr Bell is a most eminent scientist, who discovered the first radio pulsar as a postgraduate student, although, controversially, she was not listed as a co-recipient for the subsequent award of a Nobel Prize. Perhaps she has information about the Mayans and others that I don't know of, but is it possible that in this case she has not been sufficiently sceptical?
I'm interested in the question because I was myself taken in at one time by pseudo-scholarship about ancient knowledge of the precession. I was drawing on a strange book, Hamlet's Mill, by de Santillana and von Dechend. I included their ideas in my own book The Assassins of Alamut. Thanks largely to Thompson, I now know that those authors' claims are invalid, and I deleted the discussion from my book.
Posted by Anthony Campbell in sceptical stuff at 16:25 | Comments (0) | Trackbacks (0)
I'm WEIRD
A recent New Scientist article by Laura Spinney (16 November 2010) says that the chances are that, as a reader of the magfazine, I am "western, educated, industrialised, rich and democratic, aka WEIRD." In this respectit appears, I am in a minority: seven out of ten of the world's population think differently. Analytic thinking, psychological research suggests, is a minority pursuit.
The serious message for psychologists is that they need to expand their subject pool before they start drawing conclusions about human psychology, or else restrict those conclusions to the subpopulation whose members they have recruited for their study. As for you, the next time you watch a documentary about the San people or Amazonian foragers, try to remember that you're the exotic one.
I don't find this idea surprising, because I've often thought something of the kind, but I do find it disturbing. This way of thinking became dominant in the West as a result of the Enlightenment movement and it is probably essential for science to work. It also underpins the rejection of religion, which, again, is an unusual feature of modern life, at least in Western Europe.
An important difference between WEIRD individuals and those in other societies is how they think about individuality. Westerners typically attach a lot of importance to individual autonomy, whereas people in east Asia seem to think of themselves more as members of a community. I certainly recognise this trait in myself. For example, I have little interest in any team games, whereas I enjoy watching tennis and boxing.
The article seems to assume that these differences are culturally determined; "all humans have the same kind of brain." But do they? in What's New? Matthew D. Lieberman has an interesting discussion of why certain ideas, such as mind-body dualism, seem to be so deeply ingrained in our consciousness. He suggests that the answer may be found in Terrence Deacon's important hypothesis about the way languages are transmitted. Deacon believes they have evolved to be easily grasped by the human brain, especially the brains of children. In the same way, Lieberman suggests, "Big Ideas" correspond to brain structure and function and evolve over time to fit even better.
Lieberman goes on to show that there may be genetic differences between East and West in the way such ideas are taken up by the brain. Eastern cultures tend to favour ideas of the interrelatedness of individuals in society, whereas the West inclines more towards individualism. This difference may not be purely cultural in origin but may be connected with genetic differences in the regulatory portion of the serotonin transporter gene. People in the East tend to have a version of the gene that makes them more dependent on a social framework of mental health; if the framework is lacking they become depressed. Westerners, in contrast, mostly have a different genetic make-up which renders them less dependent on social and family support. Lieberman concludes that differences of this kind may help to account for differences in religion.
I can't escape from the way I see the world and I don't want to. I'm a passionate advocate of the values of the Enlightenment. But I am willing to admit that I'm in a minority, and I also think that even in the West we are witnessing a reaction against those values. They are not guaranteed to endure for all time.
Posted by Anthony Campbell in sceptical stuff at 14:50 | Comments (0) | Trackbacks (0)
Wednesday, May 12. 2010
Correcting the error in retinal design
I still remember how surprised I was as a medical student when I learnt that the mammalian eye is designed back to front. I thought I must have misunderstood. The fibres of the optic nerve are placed in front of the photoreceptors (rods and cones) instead of behind them, so that the light has to traverse the fibres before it reaches the light-sensitive area. This arrangement also produces the blind spot, where the optic nerve leaves the eye.
My surprise was of course based on a misunderstanding about evolution. Natural selection has no foresight and the structure of the eye wasn't planned; it was simply cobbled together bit by bit. According to today's New Scientist (8 May), however, the mammalian eye was later modified to compensate for this. The Müller cells support and nourish the overlying cells in the retina but also collect, filter and refocus the light to give a clearer image. So evolution first botched the design and then took steps to put things right.
What this puts me in mind of is the Hubble space telescope. Initially this was sent into space with a design fault, which had to be corrected later by a mission from earth. In that case there were of course human designers behind the telescope. If creationists wish to apply the same logic to the eye to infer the existence of a Creator they must also conclude that said Creator was as fallible as were the telescope designers. At most, this would be evidence, not for an omniscient Creator in the Christian sense, but for a Platonic demiurge - a superhuman being who did his best with what he found to hand but made a bit of a mess of things. The suggestion that this world is a computer simulation by a superhuman civilisation would also fit the facts for anyone who wishes to reject Darwinian natural selection.
Posted by Anthony Campbell in medical, religion, sceptical stuff at 14:36 | Comment (1) | Trackbacks (0)
Tuesday, April 13. 2010
Book review: The Diet Delusion, by Gary Taubes
I've just posted my review of Gary Taubes's book The Diet Delusion. This is an in-depth critical examination of the received wisdom about diet. Taubes makes a good case for rejecting the alleged link between dietary fat and heart disease and instead attributes obesity to carbohydrates. It's an excellent piece of science writing - strongly recommended.
Posted by Anthony Campbell in books, medical, sceptical stuff at 15:37 | Comments (0) | Trackbacks (0)
Sunday, April 11. 2010
David Cameron's fallacy
I was glad to hear an item on yesterday's Today programme pointing out the logical error in David Cameron's claim that couples who are married are more likely to stay together and have healthier and more successful children. The obvious fallacy in this is that the correlation, even if true, does not prove cause and effect. It is surely more likely that those couples who marry are already in a more stable relationship.
Posted by Anthony Campbell in sceptical stuff at 09:00 | Comments (0) | Trackbacks (0)
Tuesday, December 29. 2009
New light on a 'miracle'
In 1875 a Flemish labourer called Pierre de Rudder visited a local replica of the Lourdes Grotto, and apparently experienced the instantaneous healing of an ununited and infected fracture of the tibia and fibula. A section of bone was entirely missing, yet a photograph shows the leg not only whole but equal in length to the opposite leg. The healing was certified by physicians and, when Rudder died, post-mortem examination showed the bones were united and of normal length.
In her book on Lourdes, Lourdes: Body and Spirit in the Secular Age, Ruth Harris, who is not a Catholic, says that the case "dismays and perplexes".
I agree it does, but it happened a long time ago and it is always difficult to know what to say about one-off cases. Fortunately, new light is shed by an article by Joe Nickell in the current issue of Skeptical Inquirer (Vol. 34, No. 1). Nickell twice visited Belgium to investigate alleged miracles. One of these was the de Rudder case.
In outline, he has found documentary evidence which, together with the bones themselves (which show impaired alignment at the fracture site), suggest that the healing was not in fact instantaneous and might have occurred naturally before de Rudder visited the shrine. Prior to the visit he used to perform a stunt in which he demonstrated almost 180 degree rotation of the leg at the fracture site, but this was always with the limb clothed and Nickell thinks that he may have simply had unusually lax ligaments and that there may have been an element of malingering . De Rudder was in receipt of a pension from the viscount who employed him but this ceased when the viscount died; a 'miraculous' recovery would allow him to return to work without admitting he had been a fraud.
I'm glad to have this information, because I have elsewhere published my view that apparently miraculous healings are usually of disorders (including cancer) that may on occasion recover naturally. The de Rudder case might have posed a challenge to this view, but Nicholl's research offers the possibility of a plausible natural explanation.
Posted by Anthony Campbell in medical, religion, sceptical stuff at 14:29 | Comments (4) | Trackbacks (0)
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Make your own crazy creature money box to keep your pocket money safe.
Print the Crazy Creature Money Box Fact Sheet
Stick the bottom of the egg box to the bottom of the plastic bottle with tape. The egg box will make the head of your crazy creature and the bottle will make the body. Make sure your bottle has as wide a neck as possible.
Draw fins, fangs and a tail on stiff card. Cut these out and stick the fangs to the front of the egg box (forming your creature's face) and the fins to the sides of the bottle. Unscrew the lid from the plastic bottle and stick the tail to the top of it.
Scrunch old newspaper into two balls. Cover the balls in masking tape to secure them and stick them onto the top side of the plastic bottle just behind the egg box – these will form the eyes of your crazy creature.
Using PVA glue, stick small strips of newspaper all over your creature's body, tail and front of its head (this enable you to paint your creature). Once the glue has dried, paint your creature in crazy colours and patterns. You can now put your pocket money inside its bottle body, screwing its tail back in place to keep your money safe.
Try using different shaped bottles to make a collection of crazy creatures.
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text:
Relevance of ESD for key sustainable development challenge
(Cluster coordinated by Charles Hopkins, York University, Canada; International Advisory Group for the World Conference)
ESD can contribute substantially to addressing key sustainable development challenges. Indeed, without reorienting education, successfully confronting issues like water and climate change, among many others, will not be possible. Moreover, introducing sustainable development issues into all areas of education will help to make education more relevant. Engaging students and learners in contemporary questions related to development brings education closer to life and enhances the learning experience by stimulating motivation and interest. The following workshops were held in this thematic cluster:
Workshop 1: Education for Water Sustainability
Workshop 2: Strengthening the educational response to climate change internationally?
Workshop 3: Advancing sustainable lifestyles and responsible consumption through ESD
Workshop 4: ESD and disaster risk reduction: building disaster-resilient societies
Workshop 5: Educating for Food Security: the contribution of ESD
Workshop 6: AIDS, Health and Education for Sustainable Development
Workshop 7: Mainstreaming Biodiversity into education and learning
Workshop 8: The economic pillar of Sustainable Development: Educational Approaches
Workshop 1: Education for Water Sustainability
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part Place: Deutsche Post Tower (No. 4 on map)
Organizer: Miguel Doria, Division of Water Sciences, UNESCO; Charlotte van der Schaaf, UN-Water Decade Pro-gramme on Capacity Development (UNW-DPC); Almut Nagel, German Federal Environment Ministry
Documents: Background Document, Workshop Report
The workshop was based on experiences from many fields of education around the world, especially school education, vocational education and training, higher education and community and stakeholder education. The workshop included the various outcomes from regional water education workshops, national developments of member countries, examples from NGOs, among others.
The main objective of the workshop was to overview the current status of water education and identifying the way forward via recommendations to strengthen water education approaches at all levels.
The water and education workshop also demonstrated and strengthened the links between the two decades, the United Nations Decade of Education for Sustainable Development and the International Decade for Action 'Water for Life'.
UNW-DPC, UNESCO's International Hydrological Programme and the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) were cooperating in the organization of the workshop on "Education for Water Sustainability".
Workshop 2: Strengthening the educational response to climate change internationally
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Place: UN-Campus, Room 2712 (No. 2 on map)
Organizer: Laurence Pollier, UNFCCC; Philippe Saugier, Carboschools; Reuben Sessa, FAO
Documents: Background Document; Workshop Report
There has been a large bloom of educational initiatives related to climate change but so far with not much coordination/cooperation among them and there are still a large number of structural obstacles for a real integration in curricula and daily classroom work. In addition there are still big disbalances between regions of the world.
To give input to a roadmap for accelerating/deepening/strengthening the integration of climate change in curricula worldwide, through concrete proposals to the UN-system & other major international players. The workshop was therefore not only an opportunity to share experiences and expectations, but was also an action-oriented process towards a strategy for mainstreaming the educational response to climate change and reducing the obstacles which currently prevent this mainstreaming.
Key challenges related to ESD
- how can educational action progress from "raising awareness" to "understanding" and finally "acting for change"? (i.e. going from learning the facts to acting in the society).
- in formal education, how to mainstream and integrate (i) the interdisciplinary nature of CC in a subject-dominated school tradition and (ii) the development of values, new behaviors, new citizenship skills in curricula dominated by the transmission of knowledge?
- how to improve access to resources and materials and better coordination for both formal and non-formal educational purposes?
Expected output
Recommendations for a work plan (tasks, calendar, steps, actors, costs) rather than a formal/conceptual declaration.
Workshop 3: Advancing sustainable lifestyles and responsible consumption through ESD
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Place: Federal Network Agency (No. 5 on map)
Organizer: Fabienne Pierre, UNEP DTIE; Victoria Thoresen, Consumer Citizenship Network (CCN)
Documents: Background Document; Workshop Report
Consumption has become the socio-economic driving force and the core value of an increasing number of societies worldwide. While standing for a more and more important component of socio-economic models and lifestyles overall, both in developed and developing countries, patterns of consumption also have serious impacts on people and the environment when unsustainable. For this reason, and given its cross-cutting dimension, responsible consumption, otherwise called sustainable consumption, is certainly at the core of Education for Sustainable Development (ESD). ESC is indeed oriented towards critical thinking and behavioral changes, and plays a key role in the main social and environmental challenges addressed in this conference. Through the parameters of equity and sustainability, ESC contributes to turn consumption into a bearer of well-being, peace and human development.
This workshop focused on Education for Sustainable Consumption (ESC) in formal, non-formal and informal education as an integral part of ESD, building on the values upon which ESD is founded: the training of responsible citizens and consumers, aware of their fundamental rights and freedoms, informed to participate in the public debate and oriented towards a conscientious participation in the market. Through creative and interactive discussions, the workshop provided participants with the opportunity to share experiences, gain insights and consult on ways forward for the next five years of the UN Decade on ESD on how to formulate, stimulate, carry out and evaluate education for sustainable consumption. In this framework, it considered how the recent guidelines presented in Here and Now: Education for Sustainable Consumption, jointly developed by the United Nations Environment Programme, the Marrakech Task Force on ESC led by Italy and the Hedmark University College, stands as a tool to assist policymakers, teachers and parents in achieving ESC implementation.
Workshop 4: ESD and disaster risk reduction: building disaster-resilient societies
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Place: Deutsche Welle, Room Brussels (No. 3 on map)
Organizer: Olivier Schick, French National International Strategy for Disaster Reduction platform – AFCPN; Christel Rose, UN ISDR; Kristine Tovmasyan & Badaoui Rouhban, UNESCO
Documents: Background Document; Workshop Report
Every year, more than 200 million people are affected by natural hazards. In recent years, the risk of being affected by natural disasters has significantly increased, especially in developing countries due to an increased vulnerability and global climate change, which is expected to exacerbate the impact of hydro-meteorological hazards. One important aspect of sustainable development comprises the mitigation of the destructive effects of natural disasters on societies through a focus on people's vulnerability reduction. In this respect, education has been recognized as an essential component of disaster risk reduction strategies for empowering vulnerable communities and building societies more resilient to disasters through basic knowledge and skills. Knowledge and education play the pivotal role in the ability of future generations to understand and take appropriate action to minimize hazard impacts. The Decade on Education for Sustainable Development (DESD) provides a unique window of opportunity and potential turning point in history for improving formal and informal education for building a culture of disaster resilience in every community. Education and knowledge for disaster risk reduction was also recognized as one of the five priorities of the "Hyogo Framework for Action: Building the Resilience of Communities and Nations to Disasters, 2005-2015" (HFA 3).
This workshop was organized as a follow-up to a number of activities undertaken by UN International Strategy for Disaster Reduction (ISDR) Thematic Platform on Knowledge and Education in promoting education for disaster risk reduction. It consisted of multidisciplinary discussions on education and disaster risk reduction, focusing on national and local implementation of disaster risk reduction projects, which provided an opportunity for participants to exchange good practices, lessons learnt and to provide policy guidance on education for disaster reduction strategies.
Expected output
This workshop built on the ongoing dialogue and existing good practices on education for disaster risk reduction at the global, regional and local levels to enhance exchange of experiences and cooperation in developing effective strategies towards disaster prevention education implementation. The session involved a broad range of actors from the education and disaster risk management sectors and fostered an interaction between experts in disaster risk reduction, education decision makers, educators, public authorities and the non-governmental community.
Workshop 5: Education for Food Security: the contribution of ESD
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Place: UN-Campus, Room 2705 (No. 2 on map)
Organizers: Lavinia Gasperini, FAO; Benedikt Haerlin, Foundation on Future Farming
Documents: Background Document; Workshop Report
The high food prices crisis has pushed an additional 40 million people into hunger this year bringing the overall number of undernourished people in the world from 923 to 963 million. The ongoing financial and economic crisis could draw even more people into hunger and poverty (FAO 2008). The structural problems of hunger, under nutrition, illiteracy lack of access to land, credit and employment, combined with high food prices remain a dire reality. The workshop highlighted the two sided relation between education and food security and discussed positive action to promote ERP.
The objective of the workshop was to highlight that Education and specifically Education for Rural People, is essential for reducing poverty and hunger, improving living conditions of rural people, enhancing agriculture and for building a sustainable and food secure world. People – not institutions or technology - are the driving force of development. Education for Rural People, is the neglected key to food security and to achieving the MDGs.The workshop was part of the international actions aiming at contributing to eradicating extreme poverty and hunger and promoting sustainable development by increasing access to quality education. It focused both on the impact of education for rural people (ERP) on food security and on achieving universal primary education (MDG 2) and addressed ERP as a sustainable development tool and a basic human right. As a matter of fact, a recent study conducted by FAO and The University of Rome 3 found that the correlation between food security and primary education for rural people is very high.
Workshop 6: AIDS, Health and Education for Sustainable Development
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Place: Federal Ministry for Economic Cooperation and Development, Filmsaal (No. 8 on map)
Organizer: Chris Castle, UNESCO; Donald Bundy, World Bank
Documents: Background Document; Workshop Report
The impact of ill health, including AIDS and malnutrition, needs to be approached as part of a multi-sectoral development issue to which education must respond, and national authorities, civil society and donor agencies can collaborate to establish strategies to enhance the role of education in promoting sustainable development. The AIDS epidemic, in particular, is systematically eroding the capacity of the education sector, causing shortages of teachers and education staff, increasing the vulnerability of children and learners, and adding new difficulties for planning. Education for Sustainable Development (ESD) goals and methodologies provide a useful framework for developing effective responses to the causes of ill-health including AIDS. However, this framework requires adjustment to explicitly include the main causes of ill health including HIV and AIDS issues, otherwise the ability of education sector to contribute to sustainable development will be undermined.
The workshop showcased creative and sustainable educational initiatives, including through school health programmes, in response to HIV and AIDS and other health issues, and explored examples of how multi-sectoral educational programmes mobilise schools, international and community partners in responding to the needs of learners and communities, especially those heavily affected by AIDS. The importance of a holistic approach to including HIV and AIDS considerations and other major causes of ill health in ESD strategies was discussed.
Expected output
Resource people drawn from the World Health Organization, Education International, and from among those participating in the workshop, will help to set the scene by presenting case studies and aspects of relevance to the session.
Partricipants achieved an enhanced understanding of how ESD can contribute to addressing the causes is ill health, including HIV and AIDS, and the workshop has resulted in the documentation of lessons and good practice shared by participants.
Workshop 7: Mainstreaming Biodiversity into education and learning
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Organizer: David Ainsworth, Convention on Biological Diversity (CBD), Bernard Combes (UNESCO Biodiversity working group)
Place: Haus der Geschichte (No. 6 on map)
Document: Background Document; Workshop Report
Biodiversity is the foundation of human well-being. Without genetic diversity and the diversity of species and ecosystems, we would not enjoy clean water, a variety of food stuffs, protection from extreme weather, inspirational, aesthetic and spiritual experiences and other goods and services.
For this reason it is important to raise awareness of the critical role that biodiversity plays in ensuring environmental sustainability, economic prosperity and social and cultural well-being. Mainstreaming the notion of biodiversity into all forms of learning will contribute to the enhancement and/or the development of sustainable development actions, including ways of organizing thoughtful consumption and production behaviours that are sustainable from local to global levels.
During the workshop, participants engaged in group exercises to reflect on the following concepts:
- Importance of biodiversity conservation and sustainable use for sustainable development and ESD illustrated with examples from their own national experience.
- Possible ways/mechanisms to mainstream biodiversity into different contexts of learning, in the framework of ESD, focusing on identification of relevant partners and modes of engagement with these.
- Development of recommendations/guidance for action plans focused on mainstreaming biodiversity into concrete thematic settings.
Expected output
The main output of the workshop has been a set of recommendations, for an action plan on mainstreaming biodiversity in education and learning processes. This last session concentrated on producing such recommendations based on the inputs from the working groups and the plenary discussion on this subject. In this exercise, particular attention was given to the crosscutting themes of all the workshops and relevant contribution to the major objectives of the Conference: the relevance of ESD to all of education; promote international exchange on ESD and develop strategies for the way ahead.
Workshop 8: The Economic Pillar of Sustainable Development: Educational Approaches
Time: 31 March: 15.00 - 18.00h (first part), 1 April: 11.00 - 13.00h (second part)
Place: Federal Ministry for Economic Cooperation and Development, Nelson Mandela Hall (No. 8 on map)
Organizer: Dr. Manzoor Ahmed, Institute of Educational Development, BRAC University; Gisele Mankamte Yitamben, ASAFE
Documents: Background Document; Workshop Report
In line with the goal of the Decade of Education for Sustainable Development (DESD) to promote sustainable and just society for all through education as well as the objective of the mid-decade Bonn conference to take stock of progress, the workshop on the economic pillar of sustainable development and its educational dimensions, one of 22 such workshops, sought to clarify and enhance the contribution of education and learning to address key sustainable development challenges.
The focus of the workshop was on education and knowledge dimensions of the paramount economic challenge related to sustainable development, viz., sustainable poverty reduction. Empirical studies and observation have indicated key components of poverty reduction in the developing world – a) marginalization and disparity and claiming a stake for all in economic and social development; b) overcoming feminization of poverty; c) promoting sustainable production and consumption in the context of poverty reduction; d) globalization – winners, losers and threats to sustainable development; and e) developing learning and knowledge network and technology for sustainable development within the framework of lifelong learning.
Expected output
In addressing the knowledge aspects of the identified economic challenges, the workshop analyzed the status, trends and innovative initiatives in this respect and indicated the way forward. The examined action points at the workshop included establishing or strengthening learning and knowledge network and linkages, improving quality of teaching-leaning and bringing the ESD perspective into educational content and method; overcoming the digital divide; and promoting the achievement of EFA goals and MDGs – all in relation to poverty reduction.


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Down 2.2% to $6.15, CBIZ (NYSE:CBZ), is one of today's notable movers. The Dow is down 0.9% to 14,469 and the S&P is currently down 1.0% to 1,544.
In the past 52 weeks, CBIZ share prices have been bracketed by a low of $5.07 and a high of $6.63 and are now at $6.15, 21% above that low price. Over the last five market days, the 200-day moving average (MA) has gone up 0.3% while the 50-day MA has advanced 0.8%.
CBIZ, Inc. provides professional business services to companies throughout the United States. The Company provides accounting and tax, employee benefits, wealth management, property and casualty insurance, payroll, and HR consulting services. CBIZ also provides internal audit, litigation advisory, healthcare consulting, medical practice management, and other services.
There is potential upside of 30.1% for shares of CBIZ based on a current price of $6.15 and an average consensus analyst price target of $8.00. The stock should find resistance at its 50-day moving average (MA) of $6.28, as well as support at its 200-day MA of $5.89.


text:
As of Thursday, January 26, 2012
© Copyright 2014 Gwinnett Daily Post
ATLANTA (AP) -- A flash flood watch has been issued for much of north Georgia as heavy rain was expected to push into the state from Alabama.
Forecasters say rainfall of one to three inches is expected in the area Thursday evening and during the overnight hours on ground already saturated by previous rains.
The National Weather Service says the flash flood watch would be in effect from Thursday evening to late Thursday night.
It covered nearly two-dozen counties in north Georgia and included the cities of Blairsville, Calhoun, Cartersville, Chatsworth, Cleveland, Dahlonega, Dalton, and Rome.
The flash flood watch also covered parts of metro Atlanta, including Cobb and Cherokee counties.
More like this story
- Flash flood watch issued as heavy rain continues ( February 11, 2013 )
- Flash flood watch posted in parts of northeast Ga. ( September 17, 2012 )
- Rainfall, flooding expected ( November 9, 2009 )
- Flash flood warning issued for Gwinnett until 7 p.m. ( August 8, 2013 )
- Flash flood watch issued for Gwinnett ( August 7, 2013 )


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Touch Twin Marker Wood 12 Pen Set
A wood colour collection of 12 high quality Shinhan Touch Twin Markers - ideal for designers and illustrators across a wide range of industries. These pens are alcohol-based and non-toxic and are a great value alternative to the more expensive Copic and Tria markers.
The Twin Marker comes with one standard marker nib for colour coverage and one slimmer precision nib for running colour up to lines and tight colour breaks.
91 Natural Oak
92 Chocolate
93 Burnt Orange
94 Brick Brown
96 Mahogany
97 Roase Beige
98 Chestnut Brown
99 Bronze
100 Walnut
102 Rsw Umber
103 Potato Brown
104 Brown Grey
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text:
Business Partnerships:
Join Ventures
Join Ventures
Forming a
Successful Joint Venture
Important Factors to be Considered Before a
Joint Venture is Formed
Synergized from
various sources and adapted.
Most Common Causes of JV Failure
According to a recent survey, only 44% of
The most common causes of failure cited by
CEOs are:
Differences (49%)
Joint Ventures
Common Reasons for Joint Venture Difficulties
Causes for Joint Venture Failure
Forming a Successful Joint Venture
Choosing a Joint Venture Governing Structure
Joint Venture Human Resources Strategy
HR Action Steps to Prepare for a Successful JV
Model Agreements and Contracts
A preliminary MoU Between Joint
Venture Partners
Joint Venture Agreement: a
Business Partnerships
Strategic Alliances
Structuring a
Strategic Alliance: 10 Questions To Answer
Mergers & Acquisitions
Getting People Issues Right in Mergers and
Building Trust Between
Wise Negotiation DOs and DON'Ts
Negotiation Tips
Wise Negotiation DOs and DON'Ts
Negotiation Tips
Conduct During Negotiations
Managing Cross-Cultural
Cultural Intelligence
Factors To Be
screening of prospective partners
joint development of a detailed
business plan and shortlisting a set of prospective partners based on
their contribution to developing a business plan
diligence - checking the credentials of the other party ("trust and
verify" - trust the information you receive from from the prospective
partner, but it's good business practice to verify the facts through
interviews with third parties)
development of an exit strategy and terms of
dissolution of the joint venture
most appropriate structure (e.g. most joint
ventures involving fast growing companies are structured as strategic
corporate partnerships)
availability of appreciated or depreciated
property being contributed to the joint venture; by misunderstanding the
significance of appreciated property, companies can fundamentally weaken the
economics of the deal for themselves and their partners.
special allocations of income, gain, loss or
deduction to be made among the partners
compensation to the members that provide
Wise Agreement
Choosing a JV
Governing Structure
There are
three possible JV
governance arrangement: full equality; policy equality, and lead parent
Preparing for a Successful
JV: HR Action Steps
Konosuke Matsushita the legendary founder of Panasonic, put it,
"Business is people. Business success is achieved by getting each and every
person in the organization to be more successful in the job they do...
The Role of the
Business Architect
Business Architect is a person that initiates
new business ventures or leads
business innovation, designs a
winning business model, and builds a
balanced business system for a lasting success.
Model: 1+6 Elements
Business architects can be found in a multitude
of business settings: corporate change leaders, initiators of
joint ventures, managers of
radical innovation projects,
in-company ventures,
spin-outs, or
new start-up ventures.
Although the settings in which business
architects act are different, they all design and run a new venture to
achieve its
sustainable growth.
Joint Ventures / Partnerships,
Joint Ventures: Minimizing Risk and Maximizing Success,
Close Connections, Ranjit Shastri
Trusted Partners, Jordan D. Lewis
Joint Ventures Revealed, PlugInForProfit
Mastering Alliance Strategy: A Comprehensive Guide to Design, Management, and
Organization, James D. Bamford, Benjamin Gomes-Casseres, Michael S.
Strategic Alliances: Three Ways to Make Them Work (Memo to the Ceo),
Steve Steinhilber
About Joint-Venturing: The 8 Key Critical Factors of Success,
Valerie Orsoni-Vauthey
Ваш обозреватель не поддерживает встроенные рамки или он не настроен на их отображение.


text:
PEI Fire Service Study – Report Released
The fire service advisory committee implemented by Minister Doug Currie in 2011 to identify and implement measures to ensure the sustainability of the volunteer fire service in Prince Edward Island has recently received the "Environmental Scan & Gap Analysis" report on the PEI Fire service.
This study was designed to document the current state of the fire service in PEI and identify any issues. "We were previously aware of some items that have been identified over the years, but this study provides us with facts rather than speculation. The committee will be meeting in the coming weeks to review the report and see where we can make recommendations going forward. There are no big surprises." Said committee co-chair Tim Jenkins.
PEI Fire Service Study Download
New advisory committee will support the future of fire services
advisory committee will be set up to identify and implement measures to
ensure the sustainability of the volunteer fire service in Prince Edward
Island, says Public Safety Minister Doug Currie.
"Among the challenges facing the volunteer fire service throughout Canada today are recruitment, retention, service delivery, risk management, funding and training," Minister Currie said at a workshop with nearly 70 firefighters this past Saturday. "The time has come for us not only to ask questions about our future, but to start creating solutions."
Minister Currie, Robert Simonds, president of the Canadian Association of Fire Chiefs (CAFC) and Tim Jenkins, past president of the PEI Firefighters Association and the Fire Marshal's Office, met with members of the Island fire service on the weekend to identify issues and discuss ways to address the challenges.
Chief Simonds commended the province, the PEI Firefighters Association and the Fire Marshal's Office for bringing together representatives of fire services from across the province to work together to find made-in-PEI answers. He spoke about the efforts of the CAFC to lobby the federal government to implement a tax credit for volunteer firefighters and congratulated the members of Prince Edward Island Legislative Assembly for supporting this initiative.
The minister said details will be available in the coming weeks on the new advisory committee, including the committee composition and goals. He said the fire service will have ample opportunity to provide input to this board and he assured them that their input will be valued.
"Volunteer firefighters are the backbone of our province," Minister Currie said. "I am honoured to have this opportunity to work with our local Chiefs, Deputy Chiefs and firefighters to ensure the best possible service to our One Island Community, for today and for future generations."
Street Address
68 Miles Boulter Drive
Miltonvale Park, PE
Mailing Address
Charlottetown, PE
School Phone# 902-569-7660
Chief Training OfficerMiles Boulter - 902-393-1881
Proudly Canadian


text:
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Sponsored Deals
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It's whatever you want it to be.
Pretty much, anyway. This is where you find the deals that wooters like you have ferreted out and brought to light. We're thinking it'll turn into a massive database of discounted products from around the Web, constantly expanding to absorb the newest deals from the very moment their prices are slashed, with each deal immediately rated by hordes of savvy voters to spotlight the very greatest deals in the world today. Hey, we can dream, right?
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text:
HUGE NEWS THIS MORNING! Our guy LUCIANBLOMKAMP is one of the winners of FBi Radio's Northern Lights Competition! He's heading to play at Iceland Airwaves Music Festival in November!
In partnership with Iceland Airwaves Festival, LUCIANBLOMKAMP was selected from just under 600 incredible entries from all around the country (including some of their youngest entrants yet). The winners will be playing showcases at the 15th annual festival in Reykjavik this November, spending time in the studio, meeting and networking with international industry professionals and taking in the breathtaking scenery of Iceland.


text:
Caton Auto Clinic
6013 Baltimore National Pike, Catonsville, MD 21228 Map & directions
Call Now: (410) 849-0680
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"They have been taking care of our cars for about 20 years. As soon as they are off of warranty we take them..."
"Great knowledge, professional service, Kenny took great care of me during my visit. I will definitely return...."
About Caton Auto Clinic
RepairPal's Comprehensive Evaluation
Assessment Summary
Caton Auto Clinic was founded in 1975 and over the years, they have grown into the impressive auto mall they are today. You can rest assured that when you bring your vehicle in for service or repairs, the work order will be handled by one of their experienced service writers and directed to the technician most capable of taking care of the necessary repairs. Their staff of technicians is first rate, with years of experience, and many have ASE certifications. Their tools and diagnostic equipment are state of the art, providing their technicians with everything they need to get your vehicle repaired accurately and efficiently.
Message from the Shop
We have been family owned and operated since 1975! We provide an award winning service to our customers and are one of the original 7 AAA Approved Automotive Repair Shops in MD. We are Female Friendly and are sensitive to your needs with your vehicle. To see why we have won "The Best in Catonsville" two years in a row, come see us!
Auto Makes We Service
Quality Affiliations
|Check Engine Light
|Muffler & Exhaust
|Oil Change & Lube
|Roadside Assistance
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|Timing Belts
|Tire Sales/Repair
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Customer Reviews 22 verified reviews (23 total)22 Sort by: Date | Helpful
Replaced the Valve Cover Gasket that was supposed to take care of the exhaust feed back we were getting in the car. Well it didn't!! Also, did not realize that this repair was done just 11,000 miles ago at another repair shop before they did it. I have paid for this now twice and still have a problem. I guess they don't check their work.....
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text:
What is the Usain Bolt's top speed in MPH?
Usain Bolt's top speed in MPH is 23 mile. Contrary to popular opinion, Usain Bolt cannot fly. However, he does run extremely fast.
As the track and field events ramp up, Bolt will take center stage and give the world a glimpse of superhuman speed.
The questions remain: how fast and how much faster can he go?
According to Fox News, humans—who top out at roughly 23 mph—may one day be able to reach phenomenal speeds of up to 40 miles per hour.
That study showed that speed is based more on contracting muscle fibers than it is negated by sheer force of running.
If the muscle fibers that get feet off the ground are maximized, top speeds of 40 miles per hour could be reached.
Although it's interesting to know how quickly humans may one day run, what about the current crop of top runners?
Bolt may have shown his best efforts at the 2008 Beijing Games with a 100-meter time of 9.69 seconds, but he crushed that time at the 2009 World Championships.
There, he set two world records with a 100-meter time of 9.58 and a 200-meter time of 19.19. From there, we can gauge how fast truly fast can be.


text:
York's Affinity™ series has added a new dimension to the HVAC category—style. The company's 3S and 8T series 13 SEER and 15 SEER heat pumps come standard in Champagne with a choice of six other exterior colors, including Terra Cotta, Jet Black, Stone, Bermuda, Chocolate, and Gun Metal, to complement consumers' homes and landscaping.
Working with design firm Fitch: Worldwide, York designed its Affinity units to be "sleek and contemporary," with a functional but decorative metal coil guard, along with a polymer mesh for the coil protection and to extend the life of the system.
According to York, the units' steel cabinet is powder painted to withstand a rugged 1,000-plus hr salt spray test, and the new rustproof base pan is made out of an advanced composite material to provide durability and noise reduction.


text:
Frame Rating: High End GPUs Benchmarked at 4K Resolutions
Our 4K Testing Methods
You may have recently seen a story and video on PC Perspective about a new TV that made its way into the office. Of particular interest is the fact that the SEIKI SE50UY04 50-in TV is a 4K television; it has a native resolution of 3840x2160. For those that are unfamiliar with the new upcoming TV and display standards, 3840x2160 is exactly four times the resolution of current 1080p TVs and displays. Oh, and this TV only cost us $1300.
In that short preview we validated that both NVIDIA and AMD current generation graphics cards support output to this TV at 3840x2160 using an HDMI cable. You might be surprised to find that HDMI 1.4 can support 4K resolutions, but it can do so only at 30 Hz (60 Hz 4K TVs won't be available until 2014 most likely), half the refresh rate of most TVs and monitors at 60 Hz. That doesn't mean we are limited to 30 FPS of performance though, far from it. As you'll see in our testing on the coming pages we were able to push out much higher frame rates using some very high end graphics solutions.
I should point out that I am not a TV reviewer and I don't claim to be one, so I'll leave the technical merits of the monitor itself to others. Instead I will only report on my experiences with it while using Windows and playing games - it's pretty freaking awesome. The only downside I have found in my time with the TV as a gaming monitor thus far is with the 30 Hz refresh rate and Vsync disabled situations. Because you are seeing fewer screen refreshes over the same amount of time than you would with a 60 Hz panel, all else being equal, you are getting twice as many "frames" of the game being pushed to the monitor each refresh cycle. This means that the horizontal tearing associated with Vsync will likely be more apparent than it would otherwise.
I would likely recommend enabling Vsync for a tear-free experience on this TV once you are happy with performance levels, but obviously for our testing we wanted to keep it off to gauge performance of these graphics cards.
Continue reading our results from testing 4K 3840x2160 gaming on high end graphics cards!!
Throughout the story I'll have videos of our 4K footage on YouTube and to download natively. The videos include our Frame Rating overlay on them but otherwise are simple H.264 nearly 100 mbps 3840x2160 videos.
If you just want some screenshots, I have put together a ZIP file of them that you can download right here.
Also worth noting is our continued use of our Frame Rating capture-based performance testing. As far as I know, no other outlet or company (including AMD or NVIDIA) has figured out how to capture video reliably at 3840x2160 @ 30 Hz. The current maximum that was supported by the FCAT-ready reviewers was 2560x1440 @ 60 Hz. Here is a comparison:
- 1920x1080 @ 60 Hz - 124.4 Mpix/s
- 2560x1440 @ 60 Hz - 221.1 Mpix/s
- 2560x1600 @ 60 Hz - 245.7 Mpix/s
- 3840x2160 @ 30 Hz - 248.8 Mpix/s
So for the time being at least, we think we are the only ones providing you with accurate, capture-based performance testing results for high end graphics cards at 4K resolutions. I hope you find the results informative!
|Test System Setup
|Intel Core i7-3960X Sandy Bridge-E
|ASUS P9X79 Deluxe
|Corsair Dominator DDR3-1600 16GB
|Hard Drive
|OCZ Agility 4 256GB SSD
|Sound Card
|Graphics Card
AMD Radeon HD 7990 6GB
AMD Radeon HD 7970 GHz Edition 3GB
NVIDIA GeForce GTX TITAN 6GB
NVIDIA GeForce GTX 690 4GB
EVGA GeForce GTX 680 4GB
NVIDIA GeForce GTX 680 2GB
|Graphics Drivers
AMD: 13.5 beta
AMD: Frame Pacing Prototype 2 (HD 7990)
|Power Supply
|Corsair AX1200i
|Operating System
|Windows 8 Pro x64
What you should be watching for
- HD 7970 vs GTX 680 vs GTX Titan - We have combined the top end single GPU solutions in a single graph to see how they stack up and included the Titan even though it is twice the price of the HD 7970 and GTX 680.
- GTX 680 2GB vs GTX 680 4GB - Our friends at EVGA were kind enough to send us some 4GB versions of the GTX 680 so we could test how much the additional frame buffer affects performance and potentially stutter in SLI configurations.
- HD 7970 CrossFire vs GTX 680 SLI vs GTX Titan SLI - In reality, we should only be comparing the HD 7970 in CF and GTX 680s in SLI but we tossed in the Titan as well just to mix things up.
- HD 7990 vs GTX 690 vs GTX Titan - For this test we are calling the "$999 Level" I wanted to see how all the currently available thousand dollar graphics cards held up against one another, regardless of their single or dual-GPU status.
- HD 7990 13.5 beta vs HD 7990 Prototype 2 - Even though we know the frame pacing problems with the HD 7990 will continue at 4K resolutions, I have included results using the very early prototype driver from AMD with the HD 7990 as well as the currently available 13.5 beta driver.
So as I understand this new 4k tech - for desktop use only - does HDMI 1.4 spec only support 30hz refresh rates? If so, that would mean some very stuttery mouse movements (such as the difference between using 1080i and 1080p on the desktop). Very jittery mouse movement.
I am far less interested in what this new "inexpensive" new Seiki monitor can do for me in gaming and more for what it is capable of as far as desktop productivity. If my mouse if jumping around, or when trying to relocate a window, is terribly jittery and craptacular - then I will be waiting for the next gen of graphics support that will enable smooth desktop useage.
I am inclined to believe that it "should" be smooth, considering that 'eyefinity" can handle 6x1080p monitors smoothly. I would certainly love to replace the need for 6 monitors with 2 of these - which would technically provide more usable space.
Any input on this greatly appreciated. Thanks in advance.
I found this just now browsing my bookmarks.
It amuses me that the 30hz limitation is unimportant in the review. It shows a fundamental lack of understanding on people's computing needs. Get back with me when we have DisplayPort 1.2 on the thing and some real bandwidth to push practical hz.
I have this display hooked into a WC titan/ OC 3770K rig. Once you get into the service menu and turn off the TV signal processing crap and adjust the lighting, the Seiki works wonderfully as a monitor for anything windows 2D... No mouse lag or skipping whatsoever. So its QED from that perspective... Simply astonishing clarity and real estate.
Gaming? Again, disable all the tV SP crap... You are still limited by 1) signal transmission tech, and 2) this $1100 panel (yes... Search for it) can only do 30Hz refresh at UHD. At lower rez it does much higher refresh. 60Hz UHD will be a year or more before it's "affordable". At 1440p this panel looks amazing when gaming.
Question for you...
I purchased this TV and have a 4K up-scaling receiver. I would like to try it on my computer but my GTX 550 can't run that resolution. I am not a gamer but do a lot with photoshop & video editing. Is there a less expensive solution for video cards (must have HDMI out)? There isn't a lot on the internet about this subject.
Question for you...
I purchased this TV and have a 4K up-scaling receiver. I would like to try it on my computer but my GTX 550 can't run that resolution. I am not a gamer but do a lot with photoshop & video editing. Is there a less expensive solution for video cards (must have HDMI out)? There isn't a lot on the internet about this subject.
For desktop work, any low end 7-series AMD or 6-series NVidia should do it. You really do not need a high end card for windows desktop work.
Seiki just pubed a firmware update that some say addresses occasional (and very panel specific) handshake loos (1sec) BUT it knocks out the audio! Seiki responded that they are working on the problem. Seems like a lot of postprocessing and special EFX pros are buying these. (see reduser.net forum).
check reduser.net forum
Which Radeon 7990 did you use and did it require an adapter to do HDMI?
I grabbed on these Seiki TV's and currently am using it as a monitor. I have a GTX680 and am looking at upgrading to a GTX690.
What I wanted to make sure is that the DVI-D to HMDI adapter is enough to run the full resolution of the TV? I am sure that it is as you have tested it as I dont think that GTX690's have HDMI do they?
Hope you can advise?
Who would "invest in a 4K TV", taking into consideration that prices will only go down over time?
My seiki 39" can do 2560x1440 @100hz
1920x1080 @120hz using gtx 680 4gb sli. I have come across this website a lot and watched the lengthy videos without ever finding this important piece of information. (create the resolutions and test them on the NVidia control panel).
AA is useless in 4K screen, even most of ps3 games don't use aa at 720P.
No point in running 4k? Haha what a joke I run quad sli GTX690's and a 4k panel and there is no way in hell I would ever consider dropping back to a lower resolution. The difference is massive
LOL try and play at 5760x1080
I got a seiki 4k tv 39in led and with vsync off yes I get screen tearing in some parts but with the 7990 it scales extremely well. It looks fantastic batman arkham origins looks phenomenal and it plays great. Crysis 3 I had to limit to medium settings and it played great as well. As long as you disable vsync you'll get similar fps to playing in 60hz. I got the tv on sale at tigerdirect for 300 bucks! Hell might as well try it! If you have the gpu to push it you will see a difference. All of my friends that came over did they were highly impressed.
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The X-Sail is a 3.5 or 4.5m stainless steel mini land yacht that folds down into a suitcase sized bag and stows easily in your boot or under the stairs. Witness 75 year-old grannies shrieking gleefully as they overtake their grandkids, and watch as dads and mums go head to head - but most of all watch the enamel come off everyone's teeth as the grins grow ever wider. The X-sail is very simple to use; hand steered like a bike and with only one sheet - the ropey bit - to control speed. It's so easy to learn that even small kids will be proficient enough to X-sail unattended in about ten minutes. A great introduction to the wind.
The X-Sail featured in Issue #25
Kitesurfing Test - Boards 2013
Airush The Slayer
Kitesurfing Test - Kites 2013
Airush Varial-X 9 & 6M
Kitesurfing travel directory
Lake Garda


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Kid's Spaceship Bed: To Sleep and Beyond!
December 27th, 2012
There are cool dads and there are awesome dads. Redditor JeremiahGordon is the awesome type. You see, he built this cool spaceship his son Finn's fifth birthday – and it is completely amazing.
He made a loft platform for the bed, with portals that look out into space, and then created a spaceship control room in the space below the bed. Most dads would have stopped at the loft platform. Dad pieced together the master control board from junk he found in a television station's dumpster. They weren't using the stuff anymore.
It has so many switches and levers that this kid will never go to bed on time again. I hope he grows up to be an Astronaut, or at least do something this cool for his own kids when he's older. Though he could just grow up to be a TV director.
Check out more pics of the build over on imgur.
[via Gizmodo]
MORE:Geek Art + Craft | Just Plain Fun | bed | diy | kids | nasa | spaceship


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Eingang zum VolltextHome | Suche | Browsen
Bitte beziehen Sie sich beim Zitieren dieses Dokumentes immer auf folgende
URN: urn:nbn:de:kobv:517-opus-33847
URL: http://opus.kobv.de/ubp/volltexte/2009/3384/
Krahé, Barbara ; Semin, Gün R.
Explaining perceived cross-situational consistency : intuitive psychometrics or semantic mediation?
Kurzfassung auf EnglischRecent studies at the interface of social cognition and personality theory have stressed lay persons' ability to 'function as intuitive psychometricians' (Epstein and Teraspulsky, 1986). This research argues that lay persons not only show a substantial degree of accuracy in estimating cross-situational generality of behaviour, but also take into account principles of aggregation over time. In contrast, it is argued here that lay persons' perceptions of the degree of relatedness of different behaviours are mediated largely by the decontextualized semantic relationships between behavioural descriptions. This argument finds support in two experimental studies which demonstrate that the main source for subjects' judgments of 'cross-situational consistency' can be found in an abstracted knowledge base which is represented and mediated through language. The implications of the findings are drawn out for personality research. in particular with reference to domain and item selection in questionnaires for research.
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Available Colors/Styles
Detail Pics
The Spy Discord Sunglasses offer a modern, squared-off take on a classic throwback shape. The super-versatile fit works for a huge range of head shapes and sizes, and shatter-resistant polycarbonate lenses protect you from UV rays, spitballs, and the occasional rabid squirrel attack.
- Polycarbonate lenses block 100% of ultraviolet rays
- Medium to large frame size fits damn near err-body
Share your thoughts
What do you think of the
Spy Discord Sunglasses
? Share a...
- Familiarity: I've put it through the wringer
Loving these shades. I bought the tort grey which fit about a medium size (a slight bit bigger than the Spy Helm's) and would normally say too big for my face but these frames hold it together. I've gotten many compliments as they are subtle yet stylish and durable to boot. Would buy again.
Blue Heaven
Rolling Hills
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Career Center
Data Science Lecturer— Open Until Filled – Initial Review Date 4/15/14
The School of Information at the University of California, Berkeley welcomes applications for a pool of part-time, non-tenure track lecturer positions. Open until filled: The initial review date for Fall 2014 instructor candidates will be April 15, 2014, but we will be hiring additional lecturers as needed, so applications received after that date will be considered for subsequent semesters. This pool will be open until December 31, 2015; applicants who still wish to be considered after that date will need to reapply.
Applicants will be selected from this pool throughout the 2014-15 year (including summer semester) as well as the 2015-16 year, when there is curricular need. The number of positions varies from semester to semester, depending on the needs of the School. Positions typically start at the beginning of the semester, and appointments may be renewable based on need, funding, and performance. Please contact email@example.com with any questions.
We are seeking outstanding lecturers who can teach 15-person sections in our web-based Master's program in Data Sciences (datascience.berkeley.edu).
Minimum Basic Qualifications
Successful candidates will have earned an advanced degree and/or have at least five years of relevant professional experience in a technical, social science, or interdisciplinary field such as Information, Information Science, Statistics, Computer Science, Engineering, Political Science, Sociology, Law, or Economics at time of application.
Additional Qualifications
The Data Science lecturer will have research and teaching experience in at least one of the following core areas:
Preferred Qualifications
Preferred qualifications include: a record of superior academic or professional performance; the ability to be self-directed with broadly-defined limits on assignments; excellent communication skills, both oral and written; and a demonstrated ability to interact efficiently with diverse people in a highly multidisciplinary environment.
The salary per course will be determined by level of education and experience (in teaching, research, and practice).
Application Materials
A complete application requires the following: 1) a cover letter; 2) a curriculum vitae; 3) a statement of teaching experience; 4) three letters of recommendation. All letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality (http://apo.chance.berkeley.edu/evalltr.html) prior to submitting their letters. Optionally, you may also choose to provide a statement of research, interests, and experience; and pdf copies of one or more recent publications.
The University of California is an Equal Opportunity/Affirmative Action Employer. The School of Information is interested in candidates who will contribute to diversity and equal opportunity in higher education through their work.
All materials and information should be submitted electronically. To apply, go to the following URL: https://aprecruit.berkeley.edu/apply/JPF00354
About The I School
UC Berkeley's newest school, the School of Information (I School), was created in 1994 to address one of society's most compelling challenges: the need to organize and make sense of the abundance of information that we can now collect, store, and share without regard for cost or distance. The way we organize, represent, govern, and make sense of this information will shape our ability to achieve public as well as private goals.
The I School educates professionals and scholars to understand the problems and possibilities of information, to develop models of information practice, and to design useful and usable information applications, services, and solutions. This requires insights from diverse fields. Our faculty includes scholars and professionals with deep expertise in information and computer science, social sciences, management, law, design, and policy, as well as related fields.
We offer professional master's degrees and an academic doctoral degree. Our on-campus master's program (MIMS) trains students for careers as information professionals and emphasizes small classes and project-based learning. Our web-based master's program (MIDS) is the first and only degree available completely online to train data science professionals. Our Ph.D. program equips scholars to contribute to knowledge and to the policies that influence the organization, use, and sharing of information.
Our graduates work at well-known Bay Area companies that include Apple, Google, Facebook, Salesforce, Twitter, and LinkedIn, as well as at nonprofits like Kaiser Permanente and established businesses like Wells Fargo and Chevron. Many of our graduates take advantage of the opportunity to get in on the ground floor to create or work for start-ups.


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As you know, October is Breast Cancer Awareness Month, which is a time when all of the planets in the retail universe align and present us with an opportunity to shop for all things pink and wonderful while making a contribution to breast cancer research and awareness.
Breast cancer, a subject that is very close to my heart, touches so many people. My Nana is a survivor, and my Mom was just diagnosed 2 weeks ago. And so many other women who I know have faced this scary and difficult personal challenge in their lives. Now is a fantastic time to help get even closer to finding a cure. Women are amazing, and what better way to show your support for them than to rock some pretty pink?
Betsey Johnson Carryall, $75, www.betseyjohnson.com
I love everything about this tote- the pop art piece declares, "I'm a survivor!", and Betsey Johnson sure is. A breast cancer survivor of 11 years, she continues to inspire and empower women with her fearless fashion.
Redflower Candle, $34, www.redflower.com
A huge longtime fan of Redflower candles, this beautiful pink version is scented with japanese peony and topped with succulent petals (perfect for dropping into a calming bath or in a small dish as potpurri). The best part? Redflower will donate 100% of the profits of this candle to cancerandcareers.org.
Hunter Boot Original Tall High Gloss Rain Boot Limited Edition, $125, www.nordstrom.com
These Hunter Boot wellies in limited edition fuchsia have the power to liven up any damp and dreary day (or mood). Save them for a rainy day.
Estee Lauder Pink Ribbon Lucidity Translucent Pressed Powder Jeweled Metal Compact, $55 , www.esteelauder.com
Beautiful both inside and out, this gorgeous compact holds inside a magical translucent powder that brightens and airbrushes your visage in a snap.
Limited Edition Cashmere Mist for Breast Cancer Awareness, $90.00, www.bergdorfgoodman.com
A timeless fragrance for a timeless cause. Donna Karan will donate $15,000 in connection with the sales of the fragrance to benefit The Breast Cancer Research Foundation.
Ralph Lauren Pink Pony Long Sleeved Polo, $155, www.ralphlauren.com
A Pink Pony over your heart is now a symbol of compassion and a glamorous nod to all the women in your life who you love and admire. I plan to wear this chic piece with a leather skirt (and maybe those shades!). The Pink Pony Fund for Cancer Care and Prevention will receive 10% of the proceeds from each Pink Pony sale.
Forever21 Breast Cancer Strength Sweatshirt, $17.80, www.forever21.com
Whether you're lounging on the weekend or sweating it out at the gym, this comfy sweatshirt is sure to give you a little more strength! Forever21 will donate 10% of the proceeds to Susan B. Komen for the Cure and has many other adorable styles available, including nighties and robes.
BCBG Susan B. Komen Pink Ribbon Beaded Bracelet, $18.00, www.bcbg.com
Show your support with this BCBG beaded bracelet, a simple and strong statement that can be worn everyday. And 20% of the proceeds go to Susan B. Komen for the cure.
Bobbi Brown Pink Ribbon Collection Pallette, $44.00, www.lordandtaylor.com
I am a huge fan of anything Bobbi Brown touches. And like many of her other palletes which are necessities for me, this one works with all skin tones and is perfect for eyes, cheeks, and lips. The sale of each pallette will contribute $10 to the Breast Cancer Research Foundation.
KitchenAid Artisan Stand Mixer, Cook for the Cure Edition, $400, www.macys.com
Attention Domestic Divas everywhere: now you can cook for the cure with this beautiful pink kitchen accessory! You'll be the envy of the neighborhood with this baby on the counter. Not to be outdone, KitchenAid will donate a minimum of $450,000 to Susan B. Komen for the Cure in 2011.


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BEGIN:VCALENDAR PRODID:-//Systems Alliance//SiteExecutive//EN VERSION:2.0 METHOD:PUBLISH BEGIN:VEVENT CLASS:PUBLIC CREATED:20141222T112704Z DESCRIPTION:Childbirth Education Class\n DTEND:20140514T020000Z DTSTART:20140514T000000Z DTSTAMP:20141222T232704Z LAST-MODIFIED:20141222T232704Z LOCATION:Clinical Sciences Building, 2 West Classroom PRIORITY:5 SEQUENCE:0 SUMMARY:Childbirth Education Class UID:3F832778335B29F3AD8E6F1CB81A9327 X-ALT-DESC;FMTTYPE=text/html:\n\n\n\n
Address: 96 Jonathan Lucas Street
Charleston, SC
View Map Link
Childbirth Education Classes are held for four consecutive weeks, beginning with the first Tuesday of the month. Each four-week session costs $50.00 and can be paid in cash or check at the beginning of the first class. Call 843-792-5300 to register.
The Clinical Science Building is located at 96 Jonathan Lucas Street on the MUSC campus. Parking is available in the Jonathan Lucas Street Garage at 97 Jonathan Lucas Street.
Contact Name: Adina Garner, RNC
Contact Email: email@example.com
Contact Phone: 843-876-6280\n END:VEVENT END:VCALENDAR


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Jugs B5135 4 Dozen Small Balls with Bucket
Be sure to select a color, size and quantity below
Item # 3097213
|Eligible for Free Shipping, No Minimum! (see promotion details)
|Members of The League get 5% back when you spend $100! (see promotion details)
Product Details
You can load up on your back leg and drive the head of your baseball bat at these Jugs B5135 4 dozen small balls with bucket. The 5-in, 5-oz small balls are constructed of polyurethane foam.
- 48 balls
- 5 in/.5 oz
- Polyurethane foam


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My motherhood by Jenny Jacoby
01 11 2013 • My Motherhood
The decision to try for a baby came quickly and easily. For us, the pregnancy came easily too, and the whole nine months (OK, the last six months) were a dreamy happiness. In meetings at work I'd stroke my bump and think, I've got a future here inside me, and I've got company.
I didn't know what my attitudes as a mother would be like and I certainly never had a plan, but it turned out I became quite the hippy. Pregnancy yoga kept me sane and brought me very, very good friends, and I found myself planning for a drug-free labour.
Pregnancy, for me, was a journey towards giving birth. Not the bit that comes afterwards though, our lives as parents. After an afternoon of heavy contractions there were suddenly three midwives at my feet screaming at me to 'PUSH! PUSH!' and all I could think was, wait – do I really want this to be over? I'm not ready to actually have a baby!
I'm a hippy but I'm a realist too. Motherhood can be boring, frustrating, a chore – and that's after the first month of living hell. The hardest thing, once the zombie sleeplessness is done, is switching from functioning person with a useful job, to being an underpaid personal assistant for the most demanding and impatient little people. I don't mean the switch pre- and post-baby. I mean, every day of your life as a mother.
You have to be zen; only since parenthood have I really understood the importance of enjoying each instant as it comes. The heaven of your child smiling up at you and reaching for your hand will be replaced at any moment by a banshee in an inexplicable tantrum – but that too will pass. Children are programmed to love their parents, and being on the receiving end of that… there's nowhere better.
Jenny is mama to Flora, two, and a writer and editor.
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American Business Media Cuts Staff, Looks to ŌĆśNew Strategic PlanŌĆÖ
EVP Nick Ferrari out; trade group reduces workforce by 40 percent since January.
American Business Media has reduced its workforce again.
Since the beginning of the year, ABM has been forced to trim its staff by about 40 percent, according to president and CEO Gordon Hughes. The most recent cuts include HughesŌĆÖ assistant, video editor Mark Flythe and business development executive vice president Nick Ferrari.
ŌĆ£Nick was tasked with recruiting new members, which proved to be too costly,ŌĆØ Hughes told FOLIO:. Over the last six months, Hughes said five other ABM staffers left the group and their positions ŌĆ£have not been replaced.ŌĆØ ABM currently carries a staff of 12.
ŌĆ£WeŌĆÖre experiencing the same difficulties all of our members are facing right now,ŌĆØ said Hughes. ŌĆ£WeŌĆÖve always been a small operation, so any downsizing is difficult and emotional.ŌĆØ
Hughes said ABM is eyeing a ŌĆ£new strategic planŌĆØ to help prepare the group for when the economy begins to turn around. ŌĆ£ItŌĆÖs what every business should be doing,ŌĆØ he said.
Depsite cutting its video editor, Hughes said ABM will not ŌĆ£go off the air,ŌĆØ but will instead outsource its webcasting operations. ŌĆ£We also plan to take the very best of what our members are doing in digital and showcase that,ŌĆØ he said. ŌĆ£In fact, we hope to bring Mark back.ŌĆØ
Earlier this year, ABM altered its annual Digital Velocity conference, transforming the two-day, e-media-focused event into a half-day series of live Webinars, produced at the association's offices. Hughes said ABM eventsŌĆöexcluding the Neal Awards, Top Management and annual meetingŌĆöwill be produced in on-demand video format.


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Valhalla Blackpool Pleasure Beach (UK)
Sarner conceived the masterplan design for a new £15 million dark ride attraction at Blackpool Pleasure Beach. Named Valhalla this was to become a landmark ride which combines a white knuckle flume with theatrical dynamics of powerful storyline sequences. Special effects included scenic theming, fire and ice, wind and rain, mechanical and lighting
The ride incorporates fire, water, snow, thunder and lightning effects with riders experiencing extremes of temperature from minus 20C to plus 40C.
The water flume recycles more than 100,000 gallons of water a minute which is used to propel up to 2,000 riders per hour. Approximately 35,000 cubic feet of gas an hour is used to provide the flame effects. Valhalla is the worlds largest indoor ride.


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Lady Gaga Wears Gun Bra On Stage (PICS)
By Daniel Gates | 4:23 pm, January 14th, 2013PHOTOS
Lady Gaga is under fire for her latest unusual on-stage costume choice.
On Friday, the singer's Born This Way Ball tour hit Vancouver, and at one point Gaga donned a special bra with two (fake) assault rifles attached to it.
While the pop star wore a similar outfit in her video for "Alejandro," the recent spate of high-profile gun violence in the United States has led many observers to criticize Gaga's violent wardrobe.
Her weapon-adorned brassiere called to mind Madonna's on-stage rifle antics in Israel last spring.
Check out PHOTOS of Lady Gaga's gun bra performance here.
What do you think of her controversial fashion choice?
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Speed Up Google Analytics
Submitted by apachedude (Contact Author) (Forums) on Wed, 2007-03-28 17:59. :: Apache | Apache
Speed Up Google Analytics
This method uses crontab to execute a shell script that downloads an updated urchin.js file every 24 hours and saves it into your local sites directory. Thats it!
The problem occurs when google-analytics.com/urchin.js is requested by billions of web users all over the world at one time, it can cause your sites pages to load at a snails pace. Especially if you are using WordPress or a similar CMS.
Official Google Position on locally hosting urchin.js
Setup crontab by typing
crontab -e
at a unix-style command prompt (ssh) then add:
11 12 * * * /home/user/websites/urch.sh >/dev/null 2>&1
Shell script example:
#!/bin/sh rm /home/user/websites/askapache.com/z/j/urchin.js cd /home/user/websites/askapache.com/z/j/ wget http://www.google-analytics.com/urchin.js chmod 644 /home/user/websites/askapache.com/z/j/urchin.js cd ${OLDPWD} exit 0;
There are 2 pretty major things that you accomplish by hosting urchin.js locally:
One problem with remote hosted urchin.js is the server that the urchin.js file is served from does not allow persistant connections.
Another big big reason is that even though Cache-Control headers are correctly set by google-analytics when serving urchin.js, instead of responding to an If-Modified-Since header correctly with a 304 Not Modified header, indicating the file has not been modified, google-analytics instead returns the entire urchin.js file again, thus rendering the cache-control void.
You can see this problem clearly with a wireshark capture.
GET /urchin.js HTTP/1.1
Note: You will need a caching scheme on your server for optimum results.
Pretty sweet bit of overkill!


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[225] Combined Proteomic-Transcriptomic Profiling of Laser Capture Microdissected Normal and Breast Cancer Epithelium Reveals Systematic Biochemical Network Alterations
M Imielinski, S Cha, EA Richardson, D Thakur, T Rejtar, S-L Wu, B Karger, D Sgroi. Massachusetts General Hospital, Boston, MA; Northeastern University, Boston, MA
Background: Global profiling studies in solid tumors are ideally carried out on purified cell populations, such as those obtained through laser capture microdissection (LCM). Proteomic analysis of LCM samples has been traditionally limited by the sensitivity of standard analytic methods and the small amounts of tissue isolated through LCM. We have recently optimized an analytic method employing nano-LC-MS/MS to globally profile proteins in LCM tissue with a high degree of sensitivity and quantitative resolution.
Design: We profiled the proteomes of 10 estrogen receptor (ER) positive invasive ductal breast carcinoma (IDC) and 10 mammoplasty LCM specimens. We analyzed significant proteomic alterations in the context of known biochemical networks obtained from the Ingenuity Pathway database and global gene expression profiles measured in a parallel LCM breast cancer dataset.
Results: We identified 468 proteins significantly altered (289 up and 179 down) between IDC and normal epithelium (FDR<0.1). These proteins were related via multiple canonical pathways and biochemical networks obtained from the Ingenuity pathway database. IDC proteomes were altered in cavolear mediated endocytosis signaling (P<10-10) and small molecule metabolism (P<0.05) pathways. An ensemble of the most significant (P<10-30) protein-derived Ingenuity networks was significantly enriched for genes exhibiting differential mRNA expression between LCM IDC and normal breast epithelium (P<0.05). The network with the highest concordance between protein and gene expression profiles was centered at the angiotensin-II receptor, a druggable target recently implicated in breast carcinogenesis (Figure 1). Figure 1 Combined proteomic-transcriptomic analysis identifies an altered network around the angiotensin II receptor.
Conclusions: Combined proteomic and transcriptomic profiling of LCM dissected tissue revealed molecular alterations associated with breast cancer. These alterations cluster into networks that suggest novel pathophysiology and diagnostic / therapeutic targets.
Category: Breast
Monday, March 22, 2010 9:30 AM
Poster Session I Stowell-Orbison/Surgical Pathology/Autopsy Awards Poster Session # 20, Monday Morning