text:
We do not have any parts, guns, or info related to the old Iver Johnson name. Please contact your local gun dealer for any questions related to old Iver Johnson products. Thank you.
Iver Johnson manufactures and imports a full line of 1911 style pistols, and pump shotguns. If an Iver Johnson gun is not listed on this website as something we carry, then we do not have any information or parts related to the gun. We do carry a few older model magazines. Click on the "magazines" page for details.
1911A1 Boa 45acp
Eagle LR Zombie
Click "1911 Zombie" for info
Hawk Digital Navy 45acp
Click "1911 Digital Camo" for details
1911A1 Digital Snow 45acp
PAS12 PG-R/C Digital Navy
Click "Pump shotguns > PAS12 Digital Camo" for more details
PAS12 PG-R/C w/ 2 piece pistol grip stock
- With stock attached -
- With stock removed -See "Pump Shotguns" for more details.
Not available for order until further notice


text:
the finest girls pooping on the net
pictures of chihuahua tea cup poodle
infected wound in swimming pool
pool party baby boy attire
wheaten terrier cross poodle uk
boys pooping in pvc
pool in hotel room massachusetts
computer pool water tester
public pooping pics
my baby ate rabbit poop
teacup poodle full grown puppy for sale
school girls poop videosAction...
pool etiquette in italy
teacup parti poodles for sale in ga
free printable 1st birthday invitations winnie the pooh
anime poops movies
x porn pooping wc
chi poo for adoption in houstondea
classic pooh piggy bankutiliza
girl pooping pants at school
austin small backyard pool designs
pooping spycam clips
bich poo puppies in nc
mustard colored toddler poopENTER SITE
winnie the pooh baby car seat covers
maltese toy poodle rescue newport beach ca
swimming pool for dogs in canada
girl pooping on chest
Quality First Training Services
hidden shitting pooping abe rich pool cues for sale japanese discoteque poop
hidden shitting pooping
abe rich pool cues for sale
japanese discoteque poopFor information on our services click the Enter Site link above
Copyright © Quality First Training Services 2003. The contents of this site are registered and licensed to Quality First Training Services® as owned and operated by George Woodley. All images, graphics, logos and slogans are protected by the Strategis Intellectual Property Office and may not be reproduced without permission. Contact Webmaster.

subset: commoncrawl


text:
Do you want to download WinRAR for Windows 7? Apparently, WinRAR is not as popular as many think it is. I recently received a couple mails from some of you who did not know what .rar files are. You definitely need to know how to open RAR files in Windows 7 , because many sites offer them (You will find only .zip on here with a few exceptions).
Instead of downloading WinRAR for Windows 7, I often recommend people to give 7zip for Windows 7 a try. 7zip is a tool that can open RAR files and plenty of other file formats.You can find 7zip on our list of TOP10 Windows 7 Applications
WinRAR is only available as a free trial and that means that you can only use it for 30 days without annoying messages. Although WinRAR is one of those tools that allow you to use the trial shareware for longer than that you will receive a notice every time you start WinRAR. So, basically it's pretty annoying.
Download WinRAR for Windows 7
You can download WinRAR for Windows 7 over at rarlabs.com, here's the download site:
WinRAR 3.93 is the latest WinRAR edition that can be downloaded from their site (last update March 15th), it includes a couple bugfixes and other important updates.
Download WinRAR Windows 7 Themes
The only advantage of WinRAR might be that there are plenty of WinRAR themes. Yep, there are themes for WinRAR, but I suppose that 7zip will soon offer something similar.
(WinRAR Theme)
WinRAR 3.93 supports both Windows 7 x86 and x64 (pick the correct edition). If you don't know the difference, I suggest you read this article: What Windows Version do you have?
Oliver is the founder and lead editor of this site. He is interested in finding new ways to break Windows, find common errors and help others to fix them. Aside from that, he loves to fully customize systems with Rainmeter and Dreamscene, find out more about ancient civilizations like the Chachapoya, sharpen his digital photography skills and create software with a small group of selected developers. If you would like to connect with him to discuss anything, send him a mail!
Follow me on Twitter for daily updates:
Contact The Author:


text:
The WTF Hour
Comedy Bang Bang #217May 2, 2013
Lock the gates! We have an incredible one on one, getting into the actors pain interview with Marc Maron of the WTF podcast on today's special Thursday episode of Comedy Bing Bong! Marc tells us what we can expect on his new show "Maron," takes us through his past TV deals, and shares what advice he would give to a younger Marc Maron. Will things get deep enough to make Marc shed tears? Tune in to find out!
Hear the Episode
Episode Photos
Newsletter Signup
Sponsored by
Click here to find out more about the new comedy Maron on IFC!
Get a free audiobook and free trial by visiting Audible


text:
1941 Cadillac 62 Series Convertible 4 year high point restoration just completed. Gorgeous restoration of a rare classic 346 cubic in. Flathead Engine - Whisper quiet New XYZ... More
Recent high-quality frame-on restoration of 41,000 original mile California car. Ultra-rare dealer-installed continental kit. Stunning! This 1949 Cadillac Series 62 convertible is a life-long California... More
1959 CADILLAC SERIES 62 4-WINDOW HARDTOP MAGNIFICENT ORIGINAL CONDITION! 2-OWNER'S FROM NEW! ONLY 54,738 ACTUAL MILES! ARIZONA CAR! INCREDIBLE MINT ORIGINAL INTERIOR! GORGEOUS COLOR COMBINATION! DRIVES BEAUTIFULLY! TRULY ONE OF THE NICEST... More
1954 Cadillac 62 Convertible, Motor needs rebuild from long time storage. Power Top, Seats, Windows, Steering, Brakes, Autronic-eye. Work is ongoing and we do... More
Great custom ... Cinnamon Brown exterior ... Tan interior ... 394 CID V-8 ... Automatic ... Dual exhaust ... Don't miss out on this opportunity... More
1955 Cadillac Series 62 Four-Door Sedan Chassis Number: 5562130541 All original 2 owner car! Same owner from 1955 – 2013! Powered by its original 331 cubic... More
1961 Cadillac Series 62: Beautiful, elegant, low and long, this series '62 4 door hard top is a survivor. It's been given exceptional care and... More
The series 62 was the first Cadillac to enter production after World War II, and there was high demand for them. In 1947 they... More
THE 1941 CADILLAC SERIES 62 COUPE YOU ARE VIEWING IS FROM A VERY PROMINENT COLLECTION. THE VEHICLE HAS EXCELLENT DASH AND SURROUNDS WITH A... More
1957 Cadillac 62 Series Sedan, Full body work and repaint, All doors fenders, Hood and trunk removed, All door seals replaced, Re-chrome front and back bumpers,... More
Please call 989-891-0900 or email us for photographs and the details about this fine car. The car you are inquiring about is available through us... More
1947 Cadillac Series 62 Conv The first postwar Cadillac appeared in October 1945 and was virtually identical to those manufactured before the onset of World... More
YOU ARE VIEWING POSSIBLY ONE OF THE NICEST AND RAREST 1946 CADILLAC SERIES 62 CONVERTIBLES AVAILABLE FOR SALE. AT THE CONCLUSION OF WWII CADILLAC... More
1960 Cadillac Series 62 Convertible For Sale or Trade. California car, exceptionally well maintained by longtime owner. Finished in Olympic White with Red and... More
1961 CADILLAC SERIES 62 HARD TOP. . . . NEWER BEIGH PAINT ON A STRAIGHT BODY. . . . TAN INTERIOR. . . .... More


text:
Ballet Goes Broadway: Christopher Wheeldon makes his directorial debut with An American in Paris
The 2014 Dance Magazine Awards: Congratulations to this year's honorees
You vs. Your Reflection: Improve your relationship with the mirror
Choreography Knocks: Opportunities for choreographers at all levels
A Growing List of Living Female Choreographers
We want your feedback!
posted by Siobhan Burke on Tuesday, Jan 15, 2013
Show all blogs
Paul Taylor fans, mark your calendars: the Paul Taylor Dance Company is selling $5 tickets for all seats to its March 6 performance at Lincoln Center, in honor of the 25th anniversary of Taylor's Brandenburgs and Speaking in Tongues. Ticket prices for the rest of the three-week run (March 5–24) range from $10 to $160, so this is quite the steal. Here's the catch, though—you have to show up in person to get them, at one of the following places and times:
Tuesday, January 22, Noon - 2 p.m.
Chacott by Freed of London
20 East 20th Street
Between Park Avenue and Broadway
Friday, January 25, 5:30 - 7:30 p.m.
Mexican Radio
19 Cleveland Place
Between Spring and Kenmare Streets
Sunday, January 27, 2:00 - 4:00 p.m.
Paul Taylor Dance Company Studios
551 Grand Street
Between Jackson and Lewis Streets
Monday, January 28, 4:00 - 6:00 p.m.
Dancers Responding to AIDS' Dance from the Heart
Cedar Lake Theater
547 West 26thStreet
Between 10th and 11th Streets
For more information, see www.ptdc.org/five.


text:
Click any word in a definition or example to find the entry for that word
90% of the time, speakers of English use just 7,500 words in speech and writing. These words appear in red, and are graded with stars. One-star words are frequent, two-star words are more frequent, and three-star words are the most frequent.
The thesaurus of synonyms and related words is fully integrated into the dictionary entries. Click on the T button in an entry to review the synonyms and related words for that meaning.more
There's a shortage of people competent in math, science, and technology.
Chris is studying science at school.
a science teacher
the earth sciences
the modern science of ecology
This is the American English definition of science. View British English definition of science.
Change your default dictionary and thesaurus to British English.
a paid holiday given to a new employee before they start their jobBuzzWord Article
Open Dictionary
an expandable stick which you attach to a mobile phone or camera to help you take a selfie …add a word
More submissionsview entries
A must for anyone with an interest in the changing face of language. The Macmillan Dictionary blog explores English as it is spoken around the world today.global English and language change from our blog


text:
Swim Meet Saturday January 7th
Saturday January 7th, the Waukee YMCA Aquatic Center will be closed at 11:00AM and the Main Gym at 10:00AM to welcome area swim teams to participate in a swim meet. All other areas of the Waukee Y will be open regular hours.
Posted by WesleyLife
2 comments:
- AnonymousJanuary 5, 2012 at 9:25 PM
Is it possible, as a regular user of the Waukee pool, to utilize the pool at the Healthy Living Center on Saturday?ReplyDelete
Thanks for this comment. I apologize that it was not read in advance of the 7th. In order to use the Y-HLC you do need to have that membership type. All other branches of the YMCA of Greater De Moines would be available to you, with the next closest location being the Walnut Creek YMCA. Schedules can be found at www.dmymca.orgReplyDelete
Subscribe to: Post Comments (Atom)


text:
(0 Reviews) Read Reviews
Questions & Answers
Low Price Guarantee
Pinklock Clear Shields are useable with the helmets listed above or any helmet using the HJ-09 ratchet system. Simply purchase a Clear Pinlock Shield and pick from five different optional Pinlock inserts to create the Ultimate Fog-Resistant System. Shields come with a Joe Rocket Decal.
Same Day Shipping.For Most OrdersPlaced by 4pm EST.
Contact us | About us | Giveaways |Site Map |
Privacy Policy |
Affiliate Program
- Available only for FedEx Ground for 48 US contiguous states for retail customers.
- Price is before any taxes or additional shipping fees
- Not applicable for orders being shipped to an International address


text:
414 members63 Comments 55 Likes
80 members17 Comments 18 Likes
316 members63 Comments 19 Likes
Started this discussion. Last reply by Brad Churchill Jun 28, 2013. 1 Reply 0 Likes
i am new to raw chocolate but have worked a lot with couverture. The raw chocolate I have been asked to make includes cocoa mass, cocoa butter, agave and coconut oil. Has anyone had any experience…Continue
© 2014 Created by Clay Gordon.


text:
Sights & Attractions
KanchanaburiOperating day:
DailyOperating time: 09.00 - 17.00
Contact Details
Kirdkao Observatory
Category : Educational gardens
Attraction Details :
This is where you witness and gain better knowledge about stars and astronomy. Opened in 1996 to promote astronomy science, the observatory lets visitors try watching the stars through their 16-inch telescope along with guidances and lectures.
How to get there :
By Other
take Highway 323 and turn into Highway 3086 (Kanchanaburi-Bo Phloi). At Km 49
The closest destination to this result :
See & Do in Kanchanaburi :


text:
Trent Lott: White Feather-waving wannabe?
~ For the latest breaking news, be sure to join Michelle's Email List:
Posted in: Iraq,Trent Lott,White Flag Democrats
State Dept's Marie Harf: Hey, the spread of ISIS surprised even ISIS
September 29, 2014 10:03 PM by Doug Powers
Obama on 60 Minutes: US responding militarily with few global partners part of 'how we roll'
September 29, 2014 07:56 AM by Doug Powers
Obama fires up Air Force One, Marine One, huge motorcade to deliver climate change warning at UN
September 23, 2014 01:33 PM by Doug Powers
Obama announces lack of strategy against ISIS; Strategy firmly in place for Friday's fundraisers
August 28, 2014 07:05 PM by Doug Powers
Eric Holder's Justice Dept. opens 'criminal investigation' into ISIS beheading of James Foley
August 21, 2014 10:11 AM by Doug Powers
Categories: Al Qaeda, Barack Obama, Gitmo, Iraq, Media


text:
Monday, September 21, 2009
My Lime
5 comments:
- Aaron Ludwig said...
Wow! That looks absolutely photo-realistic. I licked my computer monitor.
- September 21, 2009 at 8:00 PM
- kwistin said...
Joe, that's awesome! The color and light are great, and I especially really like the texture.
The only part that gave it away for me (before I licked the computer monitor) was the end on the right side. The lines were a tad predictable when I zoomed in. But really- fantastic. I can't do this...yet....
- September 21, 2009 at 10:55 PM
- Rachael Thomas said...
It makes me want to eat at Cafe Rio... It's a good looking lime.
- September 22, 2009 at 1:06 AM
- Joel Deehr said...
no one does limes like you joe. NO ONE.
- September 22, 2009 at 9:08 PM
- Mary said...
I know I told you this in person, but dude that is one piece of citrus right there! I support you continuing your education.
- September 23, 2009 at 11:01 AM
Subscribe to: Post Comments (Atom)


text:
Current Articles
Don't miss the Golden Moose Awards on Outdoor Channel, as well as exciting red carpet interviews with outdoor celebrities on their website.
At this year's ceremony, Buckmasters's own Jackie Bushman received an honorary Pioneer Award for his decades of contribution to outdoor television. The 2013 season will make Buckmasters the longest-airing hunting show of all time, with 26 years.
The 90-minute Golden Moose Awards special will air twice. Once on Tuesday, April 2, 2013 at 10:30 p.m. (EST) and again on April 4, 2013 at 7 p.m. (EST), so set your DVRs!
Beginning Friday, March 29, look for the red carpet interviews on Outdoor Channel's website.
For more on Jackie's Pioneer Award, as well as a list of other winners:
Customer Service • Email Us • Advertise
© Buckmasters.com, All Rights Reserved. • 10350 Highway 80 East • Montgomery, AL • 36117 • 334-215-3337


text:
I'm 23 and currently living in Florida. I'm a southern girl. I spend most of my time working and traveling.
Join OkCupid
Find better matches with our advanced
Find better matches with our advanced
matching system
—% Match
—% Enemy
23 • Vero Beach, FL • Woman
I'm looking for
- Women
- Ages 19–30
- Near me
- Who are single
- For new friends, long-term dating, short-term dating
My Details
- Last Online
- Dec 9
- Orientation
- Gay
- Ethnicity
- White
- Height
- 5′ 5″ (1.66m)
- Body Type
- Curvy
- Diet
- —
- Smokes
- No
- Drinks
- Rarely
- Drugs
- Never
- Religion
- —
- Sign
- Gemini, but it doesn't matter
- Education
- Working on university
- Job
- Other
- Income
- —
- Relationship Status
- Single
- Relationship Type
- —
- Offspring
- Doesn't have kids, but wants them
- Pets
- Has dogs
- Speaks
- English
Similar Users
My self-summary
Write a little about yourself. Just a paragraph will do.
What I'm doing with my life
Don't overthink this one; tell us what you're doing day-to-day.
My job is my life right now and I'm working on graduating college.
I'm really good at
Go on, brag a little (or a lot). We won't judge.
I'm really good at helping people. That's my job and I enjoy it very much!
The first things people usually notice about me
I'm an empty essay… fill me out!
I'm pretty funny and can be outgoing. I love to have a good time.
The most private thing I'm willing to admit
I'm an empty essay… fill me out!
I'm very open, so I'll probably answer any question you ask me. I have nothing to hide :)
You should message me if
Offer a few tips to help matches win you over.
You find me attractive, aren't ancient, and think I might be interested in you.
Connect your existing OkCupid account
Sign in
Welcome Back!
Restore your account to continue meeting new people.
Reset your password
We'll email you a link to reset it.
Email sent!
An email is on its way to . If you don't see it, try checking your Spam folder.


text:
Your browser doesn't have support for real-time updates. Please install flash or upgrade your browser.
Universities & Education Event ·
Columbia Journalism School and The New York World are convening journalists and journalism educators from across the U.S. for a one-day conference on the growing role of academic institutions and their students and faculty as news-reporting resources in their communities and beyond. Panels will cover effective practices in teaching through the production of journalism; the experiences of professional newsrooms that have collaborated with journalism programs; making the most of opportunities for innovation and public engagement; and the legal issues that educators and institutions of higher education must navigate in their roles as content generators. For more infomation http://www.journalism.columbia.edu/event/861/14


text:
Attention all cats, New Zealand is teaching dogs how to drive
Dogs can do all sorts of amazing things from leading the blind, to sniffing out drugs, but now it looks like they may soon take over behind the wheel too. Best of all, unlike those robotic Google drivers, these guys will shower you with doggie kisses when you get to your destination.
To show just how smart and useful their shelter dogs can be, the New Zealand SPCA has taught three dogs how to drive a car. As if that wasn't cool enough by itself, the car also has a manual transmission, requiring the dogs to change gear as they cruise. Heck, my 16 year old niece hasn't even mastered that skill yet.
The Mini Clubman has been modified for canine control, with a padded steering wheel and gear shift, and
hand paw controls for the brake and accelerator. At first the dogs were trained using a mockup of the driving controls, but once they had mastered that, they hit the track for a little on-the-road action.
Porter, Ginny and Monty are all rescue dogs that had been abandoned, but now that they have wheels, I would suggest moving if you happen to be one of their abusive former owners.
Check out the video to see Porter driving around the track.


text:
Posts Tagged: queen bee
Hail to the Queen
Oh, to be a queen bee...
Her Royal Highness (HRH) is quite pampered. She's always surrounded by her royal attendants, called the retinue. They tend to her every need. They feed and groom her. They keep her warm or cool, depending on the temperature inside the hive.
They know it's her and not an imposter. Her Excellency releases a pheromone (chemical) that identifies her.
The retinue--with attendants circling the queen--reminds me of a NFL quarterback huddle. Form a tight-knit circle. Strategize. Criticize. Motivate. Win the game. Celebrate.
The queen bee, however, is no quarterback.
The worker bees (females) run the hive. They're the builders, architects, foragers, guards, royal attendants, coolers and heaters, nurse maids, nannies and undertakers.
The queen's only duty is to lay eggs. In peak season, she lays as many as 2000 eggs a day. She's the mother of all the bees in the hive, which can amount to 45,000 to 60,000 in the summer.
Ever seen a "classic retinue" photograph? Bee breeder-geneticist Susan Cobey, manager of the Harry H. Laidlaw Jr. Honey Bee Research Facility at UC Davis, shared this photo (below). Note that ALL the royal attendants are facing her, which is what makes this a "classic retinue" instead of a your basic everyday retinue.
Hail to the queen.
But the real salute, the real applause, the real credit, should go to the workers.
They do all the work.
Classic Retinue
Queen Bee
Not All Sweetness
The honey bee hive is not all sweetness.
The first virgin queen bee to emerge from her cell (each queen cell resembles a peanut shell) will rid the colony of her competition.
After emerging, the queen makes a mark on the other queen cells. That's an indication--or really, an order--for the worker bees to destroy the developing queen inside, says Cooperative Extension Apiculturist Eric Mussen of the UC Davis Department of Entomology faculty..
There can, after all, be only one queen bee in the hive.`
"The queen bee develops from a fertilized egg that hatches three days after being laid," wrote authors Eric Mussen, Len Foote, Norman Gary, Harry Laidlaw, Robbin Thorp and Lee Watkins in the UC Agriculture and Natural Resources booklet, Beekeeping in California, published in 1987. "Nurse bees, a class of worker bee, feed developing queen larvae a special diet consisting mostly of the royal jelly that they secrete from their glands. This special diet shortens the time spent to reach maturity to 16 days, compared with 21 days for the worker bee and 24 for the drone (male). The result is a bee larger than any others, with fully developed ovaries and a very large abdomen."
"The queen," they explain, "is reared in a large cell resembling a peanut shell that hangs vertically from the comb and about 10 days after emerging, she becomes sexually mature."
Then she takes one or more mating flights, mates with 10 to 20 drones, and returns to the hive to spend the rest of her life laying eggs. In her two-to-three-year life span, she'll lay about 1000 eggs a day. In peak season, she'll lay about 2000 eggs a day.
She's queen for the day, and every day.
Queen Cell
The Queen Bee
If you were a queen bee, you'd be laying about 1500 to 2000 eggs today. It's your busy season.
"She's an egg-laying machine," said bee breeder-geneticist Susan Cobey of the Harry H. Laidlaw Jr. Honey Bee Research Facility at UC Davis. "And she's the mother of all the bees in the hive." During the peak season, that amounts to about 50,000 to 80,000 workers (sterile females) and 1000 to 2000 drones (males).
Worker bees take care of her every need. They feed her, groom her and protect her, Cobey said, "and then they have the additional tasks of rearing and feeding her young."
The queen bee is easy to spot in the hive; she's the biggest bee. And wherever she goes, you'll see her court (workers) surrounding her.
Beekeepers mark her with a colored dot on her thorax so she's easily visible. (School children, when asked to single out the queen bee, say "She's the one with the dot!")
On her maiden flight, the queen bee mates with some 12 to 25 drones and then she heads back to the hive to lay eggs for the rest of her life, "usually two or three years," said Cobey, who is internationally renowned for her classes on "The Art of Queen Rearing" and "Instrumental Insemination and Bee Breeding."
The queen bee destroys any and all competitors for her "throne" by stinging and killing them. Unlike worker bees, she does not die after she stings.
Interestingly enough, only female bees can sting. Drones, or male bees, have no stingers (despite what Jerry Seinfeld's character said in The Bee Movie). Their only purpose is to mate with the queen. Then they die.
It's a matriarchal society. The girls (worker bees) do all the work; they serve as nurses, guards, grocers, housekeepers, construction workers, royal attendants and undertakers. It's not surprising, then, that during the summer, their life span is only four to six weeks.
Meanwhile, if you're the queen bee, there's no reproductive rest for you! You have about 1,999 more eggs to lay today.
The queen bee and her court
A Marked Queen Bee


text:
Author Archives: Malea
Chinese Foreign Aid: Can It Help the World's Women?
All eyes turn to China this week, as it hosts the summer Olympics, but many look with deep suspicion. Many in the West – including the media, policymakers, and the general population – don't know how to approach such a … Continue reading
Posted in International Policies Tagged International Policies Leave a comment
Global Climate Change: What Does it Mean for the World's Women?
Malea Hoepf Young is a Research Associate at PAI. It's apparent from recent news that climate change is finally getting the attention it deserves, even if the United States is still dragging its heels on addressing the issue. But even … Continue reading
Posted in Climate Change Tagged Climate Change Leave a comment


text:
With the Verso Mill in Bucksport, Maine having a tentative closure date of December 1st, area rail followers and photographers are putting a lot aside in order to get Bucksport Branch trains befor... (more)
The railcar has 32 seats and was built by Billard in 1938.
It could be a picture of the sixties: Just a few passengers in the railcar, and a trailer for baggage and small goods.
Steamrail charter train enroute from Newport to Southern Cross.
313,956,and 957 work into Aqaba Depot with a failed U17, 957. The failed loco will be taken off before the train continues to the unloading terminal in the port, This shot was taken from the depo... (more)
I chased the Plover Way Freight the 15 miles from Plover to Wisconsin Rapids hoping to a low-sun nose shot of the 313. It wasn't until the train entered Wisconsin Rapids yard that the huge cloud t... (more)
#4 rolls into Wisconsin Rapids in the last rays of sunlight. Normally, this train operated with just one unit, but on this day, #2's crew wasn't told to drop #313 at Wisconsin Rapids prior to depa... (more)
Grain train to Hodos, Slovenia
First color shot: northbound CV66 (running ahead of schedule as X313North).
In a heavy rain, L&N #66 leaves Appalachia, VA en route to Corbin, KY
Transfer from Wisconsin Rapids stops at depot for paperwork. 11:00 AM


text:
Please log in or register to manage your account
Model: 105818LCC Item: HON105818LCC
Hard-working, good-looking and built to survive a lifetime of overtime. Durable abrasion- and stain- resistant laminate. Grommet on worksurface for cable management. Full-height modesty panel for privacy. For use with Curved Corner Workstation only. Not freestanding. Color: Harvest; Pedestal Count: 1; Drawer Configuration: Left: Box/File; Overall Width: 42".
HON® 10500 Series Two-Shelf End Cap Bookshelf, 24w x 24d x 29-1/2h, Mahogany
$332.26$22594 / each
HON® 10500 Series Laminate Bookcase, Two-Shelf, 36w x 13-1/8d x 29-5/8h, Mahogany
$251.99$17891 / each
HON® 10500 Series Kneespace Credenza With Full-Height Pedestals, 72w x 24d, Harvest
$977.26$60590 / each


text:
The New York Knicks lost to the Detroit Pistons on the road, recording their seventh straight loss. The Knicks now sit 19 games under .500 and their playoff chances are fading away day-by-day.
- If you want to have a career night on the court just circle the Knicks on your NBA calendar if you're an opponent. The question lately is becoming which opposing player is going to go off? Last night it was Andre Drummond who torched the Knicks with 17 points, 26 rebounds, 3 blocks and 2 steals. Detroit has been a disappointment this season given the talent on their roster, but Drummond has a really bright future and continues to grow every time he takes the court. For the Pistons the win snapped a four-game losing streak of their own and kept them within striking distance of a playoff shot.
- Carmelo Anthony put up another 28 points in a losing effort to go along with 5 rebounds and 2 assists, but he also had six turnovers which is a lot for a front-court player. Anthony shot 11-21 from the field and continues to play a high volume of minutes night in and night out, but his effort is more than commendable thus far. At this point it even seems like Anthony has thrown in the towel on this season.
- Coming into this game I said Brandon Jennings would have a major impact on the game, but I was wrong. Granted he finished with 9 points and 11 assists on the night, but he's still struggling with his shot as he has throughout the year. Instead the backup guards WIll Bynum and Rodney Stuckey combined for 32 points, 16 apiece, and both shredded any Knicks guard all night. Most of their points came from drives to the basket, which just goes to show you it's not just the Knicks perimeter defense that is struggling, but the interior defense as well. Which, then, equals the whole defense.
- Mike Woodson elected to change his starting lineup looking for a scoring punch so he inserted Amare Stoudemire and J.R. Smith. Stoudemire played very well finishing with 22 points at 6 rebounds, but continues to be a terrible defender. At this point, we all know who Stoudemire is and he'll never play solid defense. J.R. Smith continues to have a terrible season and it doesn't matter if he starts or comes off the bench. Smith finished with 16 points, but shot just 5-17 from the field including 4-11 from three.
The plan ultimately backfired on Mike Woodson because by taking away all the scoring from the bench, that second unit came on the floor and couldn't score whatsoever. As a matter of fact the bench finished with a total of 7 points, all of which came from Iman Shumpert and Pablo Prigioni. The young guns, Jeremy Tyler and Tim Hardaway Jr., both finished with zero points and played decent minutes.
- Raymond Felton continues to struggle as well and just seems to have lost his game completely. Personal life aside, Felton hasn't been this bad since his days in Portland with the Blazers, and the way he is talking to the media you have to think his head just isn't in the game right now. Felton scored 4 points on the night along with 5 assists, but also had 4 turnovers. He shot 1-9 and his defense continues to plague the Knicks, but unfortunately they don't have many options at the starting point guard position at this point.
-Stat of the night: No Knicks player who played above twenty minutes played, had a positive grade in the plus minus category. The lowest player in that department was Carmelo Anthony with a -17. A lot of people don't take this statistic seriously, but to me it shows just how inefficient the Knicks are as a team, they have no balance or continuity on the court as a team and their record shows this. Case and point the Pistons are among the worst defenses in the league and the Knicks only managed to score 85 points as a unit.
Coming up next for the Knicks is a trip to Minnesota to play the Timberwolves followed by a game at MSG to play the Utah Jazz. They finish the week on Saturday with a game at the Cleveland.


text:
The domain fashiongames.biz may be for sale by its owner. Click here to make an offer.
Related Searches
Fashion Games
Shooting Game
Dress Up Game
Fashion Show
Dress Up Girl
Girl And Fashion
Game Fashion Designer
Car The Game
Game Fashion Barbie
Game Fashion Solitaire
This domain may be for sale.
Buy this Domain
Privacy Policy


text:
Home ›
Air Date:Tuesday, Dec 17th - 7:00pm
Episode Title:The Copper Country Strike of 1913
An epic labor strike that devastated Michigan's Copper Country in 1913 haunts the American labor movement to this day. Among the notable elements of that strike was the death of 73 children at a union Christmas party, a tragedy immortalized by Woody Guthrie in his ballad "1913 Massacre," performed in the film by Steve Earle.The event remains the deadliest unsolved manslaughter in U.S. history. This program traces the Copper Country strike from its hopeful start to its heartrending conclusion. Between those endpoints, it explores the intensifying battle between organized labor and corporate power, as well as issues of immigration and technology. Richard Harris narrates.
- Home
- Support
- TV Schedules
- Community
- Education
- Productions
- Inside WCTE
- WCTE Public File


text:
Mine was July 25, 2006 with Dr. Sawyna.
I get to see him again next Wednesday for gall bladder surgery.
I am scheduled for July 30. Anyone else?
Post-Op, Dr. Holland, 7/30/07, Down 100 lbs
I have been reading the forum but not posting. My name is Lisa and I am also scheduled for July 30th with Dr. Holland.
It was so nice to hear from you. Since you are scheduled for surgery on the same day as me, you probably will be at the Team Meeting on July 16 (9:00 am)? I am looking forward to meeting you. Will you be at the Support Group meeting on July 11? I will be seeing Dr. Holland in the morning; then go to the meeting at night.
It is so much fun to check this forum and talk back and forth with everyone. I think that I have become addicted to the forum. It's the first thing I check when I turn on the computer in the morning! Our "big day" will soon be here. I am so excited about it!
I leave for a vacation tomorrow and won't be back until the 23rd. I already had my team meeting and my last appt. with Dr. Holland is on the 25th. I am so glad that I am going away so that the wait doesn't seem so long until the surgery. Hopefully we will meet at the Aug. or Sept support meeting.
July 2, 2007 with Dr. Holland
Oct 31, 2008 Twisted Bowel and Double Hernia Repair with Dr. Holland
I am almost home!
Keep up the good work! So glad that you are doing so well. Keep us posted!
I am still on clear liquids, but tomorrow I begin the full liquids. So tomorrow I get a few more
delicioustreats. I am doing well except the back pain I have from not moving and lying a certain way in bed. That will pass though.


text:
Covering the latest concepts, theories and methods from both applied and theoretical aspects of the social sciences, this resource provides indexing and abstracts for a wide assortment of the most important English-language social science journals.
Broad Subject Coverage
Subject coverage in Social Sciences Abstracts covers a wide array of areas, including addiction studies, ethics, public welfare, urban studies and much, much more.
Advanced Search, with its elegantly laid-out tool set for crafting very precise search strategies, gives the user great control over the whole search process.– Library Journal


text:
El Jardín Secreto - The Secret Garden
Federica & Co. Calle de Hermosilla, 26. Madrid.Taken by susielomovitz with an Olympus Pen EE-2 loaded with Lomography Color Negative 400 (35mm) film (available in our Online Shop) in Madrid, Spain. These tags describe this photo: frame, half, pen, olympus, madrid, co, &, federica, secret, secreto, garden, and jardin. Date: 2013-02-09. Time: Morning. This photo can also be found in the album EL JARDÍN SECRETO.
Please login to get more out of this site
You are currently not logged in, do so now to add comments, like articles as well as photos, submit to competitions, translate articles and gain access to unlimited photo upload! If you are not registered yet, go here to find out more about Lomography and join now! If you just want a limited account for now you can use Twitter or Facebook. We would love to have you as a member here!
29 people like this photo
Liking photos helps us to present the best ones to you and others. 29 people like this photo. 29 people like this photo: happygaivot, carmengraphy, isabel_mebarak, triky76, magic_isolette, wuxiong, weleasewoger72, kelvin_wx, stefbystef, paula412, mafiosa, funfun, jaalvarez, pogolomo, myfolkway, alisanri, guanatos, vgzalez, domemerson, littlekoala, alexyz, yomimmo1, ibone, clickiemcpete, bisilala, happytea, rik041, blueskyandhardrock, and pearlgirl77.


text:
Karran Laguna Double Bowl Self-Rimming Drop-In Sink
Shown in White
Available in White and Bisque
Price $252.50
No Sales Tax, Except CT
Product Reviews
The Laguna Double Bowl Self-Rimming Drop-In Double Sink by Karran offers a clean and simple kitchen sink look with a lot of function for your kitchen. Our kitchen sink features two bowls perfect for preparing food, washing dishes and more. With a tough acrylic and resin construction reinforced with a polyester & fiberglass mix for added durability, our ultra-functional Laguna kitchen sink from Karran offers a versatile kitchen sink surface that is virtually stain proof, sure to last for years. These tough, yet elegant sinks are heat resistant up to 365 degrees and can withstand thermal cracking for the highest quality look possible. Our drop-in kitchen sink is suitable for all styles of countertops, whether its granite, laminate or other, with your choice or white or bisque finishes to best match your color scheme. With its non-porous surface, the Laguna Double Bowl Kitchen Sink is bacteria resistant, making it a clean, safe and smart sink choice for you and your home. Enjoy the easy maintenance of our Karran sink; simply wipe down with a cloth or sponge for a sink for truly simple cleaning.
(W = side to side) (D = front to back) (H = top to bottom)
Overall: 33" W x 22" D x 9 / 7-1/2" H
Inside dimensions:
LB: 17" x 17-1/4" x 9"
RB: 10-1/4" x 16" x 7-1/2"
Ship Method:


text:
April 30, 1994 Does America Need Masters Of Wine? By Matt Kramer We Americans have always had a fondness for British ways of doing things. Partly, it is the sheer exoticism. Partly, it is the reward of a successful revolution: We can afford to love them.
For the full article, check out the new issue of Wine Spectator, on newsstands April 30, 1994.
Do you have a Wine Spectator magazine subscription? Save 50% on your Online Membership right now!
Sips & Tips | Wine & Healthy Living
Video Theater | Collecting & Auctions
» View samples
» Or sign up now!
» Manage my newsletter preferences
The marketplace for all your wine needs, including:
Wine Storage | Wine Clubs
Dining & Travel | Wine Auctions
Wine Shops | Wine Accessories


text:
My sister loves this ride
Sehr schön wie das Sperma aus ihrer Möse tropft. Würde mich zu gerne darunter legen und es mit dem Mund auffangen ;))
thanks that was hot u could tell how much she enjoyed it
OH my god his testicles hang so looooooow!! My dick is getting soooo hard watching his nuts dangle and sway while he knot-fucks that generous lady. Thank you for posting this!
MM it feels good i did it with my dog
She sure was working her pussy trying to hold on to that cock
lucky girl!
i like this video
how i wish i was that dog. I would mount her every day,that ass is worth it.It diserves it........... over and over and.....
trade places lucky girl!


text:
This past weekend a few of us AkkenCloud® staff members got a chance to visit Montreal for the Formula 1 Grand Prix. While we were excited for the race, we couldn't help but think about the scale, and logistics needed to staff a massive event like this. Thousands of employees are required to staff the many vendors, security, hosting, catering, and hospitality roles that a world-class event like this requires. With the venue for Formula 1 races changing constantly, traveling from different cities in different countries every few weeks is a must. However, moving employees from one race to another would be financially impossible, so temporary staffing provided by local companies is the only practical way an event like this could be put on without spending a lot of time and expense.
The Grand Prix is no ordinary sporting event. No matter what the city, the race may be the highlight, but dozens of events from concerts, parties, and more are put on to entertain race goers for the three days of racing and you cannot do all this without social recruiting software. The race attracts a global fan base wherever it goes. The Montreal Grand Prix reliably attracts over 300K avid race fans to the city, and this year was no exception. The city and racetrack were packed for the spectacle of the race.
Events like the Grand Prix may be rare, but they offer excellent opportunity for staffing agencies with great recruitment tools. The influx of tourists to a city, and the number of events that are going on during the Grand Prix means that demand for temporary employees will increase not just at the racetrack, but also all over the city. The Grand Prix depends on these local temp agencies to fill the majority of the positions, as few full time employees (other than racers, and crews) actually travel, and work each of the events.
Major sporting events—even minor sporting events, provide a huge market for temporary staffing companies who can utilize social recruiting. These events don't provide enough steady work for most employees to be hired full time. Venues may have schedules of events that take place days or weeks apart, and this forces a stadium to rely on temp workers to fill the roles that are required.
So the next time you are at a major event, or if you are lucky enough, the Grand Prix, think about the role staffing companies and recruitment tools and the hundreds of temporary employees they represent play in bringing these shows to life.


text:
Home / Contact Us
Arca Solutions, Inc.7004 Little River TurnpikeSuite OAnnandale, VA 22003 USAFone: +1 703 914 0770
Please enter the text you see in the image at the left into the textbox. This is required to prevent automated submission of contact requests.
Copyright © 2014Arca Solutions, Inc. All Rights Reserved


text:
Unlock the entire Houzz
62 Freeland, PA Environmental Services and Restoration
Has your Freeland, PA home been damaged by a flood? Or do you have to deal with mold removal? Environmental services and restoration professionals can help with everything from supplying you with mold test kits to helping restore and rebuild your home, returning it to its original condition. More
Dries Properties LLC (610) 297-5761
Dries Properties LLC, your Lehigh Valley Remodeling Contractor, is as dedicated and professional with every remodel project as we are with any custom home building project. Our... Read More
Non-profit housing design & development of single family homes Read More
List your business here for free - Learn More


text:
This event brings together friends, neighbors & families with food music & fun. Enjoy a collection of Northern Colorado restaurant fares, vendor booths, children activities & live music. Bring your picnic blanket, lawn chairs and favorite friends for a summer night out. Plan on enjoying dinner & desserts from an array of food vendors. Beer garden available on site.
Date: Thursday July 17th, 2014
Time: 4-8:30pm
Location: Boardwalk Park
Free admission, Free parking, Free music!
2014 band: EUFoQUESTRA
An ever-evolving sound that has been igniting dance floors across the country, blending the roots of funk, soul, afrobeat, reggae & dub to create a sound that is energy & rhythm personified.
Contact information:
The Tribune 970.352.0211
Vendor Information:
Learn more about becoming a vendor »


text:
Introducing myself and my journal: Happening People
About Me:
Worked with the British and Irish Agencies Afghanistan Group (BAAG) from 2001 to 2004 and after September 11th provided daily information to Government departments on the situation in Afghanistan.
Seconded to the Agency Coordinating Body for Afghan Relief (ACBAR) in Kabul where Jeanne assisted the new Director with office systems, website, training and the ACBAR newsletter.
Produced the AfghanLinks e-newsletter – and wrote the editorial (published since October 2004) that provided up to date information on security, cultural issues and humanitarian needs the Media, NGOs and researchers.
First visited Afghanistan in 2000. Went to Badakhshan, to report on agricultural projects, and Kabul; last visit to Kabul and Kandahar in April 2008. Visit to Kabul organised for January 2012.
Brief Career History and Education
In addition to Afghan work and writing I have many years of experience in business, in particular in marketing, selling and buying. For four years I worked for Zambia Engineering Services on copper and coal mine contracts funded by the European Union, the International Reconstruction and Development Bank and the African Development Bank.
BA (Hons) 2.1 - from the University of Kent at Canterbury - in the History of Central Asia since the Moghul era through to the Partition of India; her university education included the study of Islam.
Member of the Front Line Club in Paddington www.frontlineclub.com
My Passions:
Justice and Human Rights
My Challenges:
Helping women and children in Afghanistan
My Vision for the Future:
Security for women (and men) to walk and talk freely
My Areas of Expertise:
Afghanistan Writing
Welcome to World Pulse Jeanne
A warm welcome to you Jeanne. I am sure you will find the World Pulse community worthwhile! Reading through your profile, I realized that you would have a lot to share and I look forward to learning more about you and your work through your journal entries on World Pulse. There's so much to explore in this community and I wish you the best of times here.
Warm regards!
Hello and welcome!
Hello and welcome to our online community, Jeanne!
Wow, you have a tremendous wealth of experience! I am thrilled to see you're with us here, in our network of activists and change-makers from 190+ countries. I am sure you'll enjoy connecting with some new people and sharing some ideas for making our world a better place.
I look forward to hearing your voice here! I imagine you have an amazing set of stories to share.
Let me know if you have any questions about the site, or you can check our Getting Started Guide for some helpful advice (http://worldpulse.com/pulsewire/about/guide).
Again, welcome!
Kind regards,
Scott Beck
World Pulse Online Community Volunteer


text:
Welcome to Termo Records
Out September 19th 2014:
The absolutely monumental debut from Norway's dark electronica sensation Three Winters, Chroma. If you like John Carpenter, Tangerine Dream, Zombi or anything else electronic and cool, you'll want this.
Press here to hear Three Winters on youtube.
White Willow Ex Tenebris and Sacrament reissues. Remastered, w/bonus materal! Also out September 19th.
Press here to hear White Willow on youtube.
Go to our links to find your nearest distributor or go to our termo-shop to buy it directly from us.


text:
Bruno Senna says there was nothing he could have done to prevent his accident after aquaplaning on standing water in Friday's second practice.
Attempting to learn as much as possible in the treacherous conditions in Friday's second practice for the British GP, the Williams driver lost control of his car when he hit a patch of standing water.
Senna aquaplaned off the track and into the barriers, causing significant damage to his Williams.
"Unfortunately we didn't have a very productive day in the end," said the Brazilian.
"The weather was poor weather with puddles on the track during second practice.
"On my second run, I aquaplaned on some deep water at the high speed Becketts section of the track and from that point was I a passenger until the car hit the wall.
"It was quite a heavy accident but I am okay.
"There is a lot of damage to the car but the Williams team will, I'm sure, do a great job of getting it back into shape."
Any reproduction, publication or redistribution of this material without the written agreement of 365 Media Group is strictly forbidden.


text:
Not a Member? Forgot Password?
Join our free gold club to start saving £££ on your table bookings and orders. Join today and we will give you coupons for the following offers:£2.50 Off Takeaway£10 Off your Meal
To start a table booking please enter your details below...
First Name(*):
Last Name(*):
You may enter booking notes and choose any offers in the next step.
We think you may already be a member, if so please login:
Powered by Order Wizard - Restaurant Marketing - ©2014 Arbutus Ridge Ltd - Terms of use - Privacy statement - Mobile Site


text:
The Eighth Day of Creation: Makers of the Revolution in Biology
Simon and Schuster, 1980 - Science - 686 pages
This historical account of the revolution in molecular biology discusses the important, far-reaching discoveries, the scientists who made them, and their immense promise for research, for medicine, and for industry
From inside the book
28 pages matching lactose in this book
Where's the rest of this book?
Results 1-3 of 28
What people are saying - Write a review
User ratings
|5 stars
|4 stars
|3 stars
|2 stars
|1 star
Review: The Eighth Day of CreationUser Review - Ian - Goodreads
I found it enthralling. An indepth reportage of the events, research and personalities leading to the elucidation of the structure of DNA in 1953 by Watson and Crick. Read full review
Review: Eighth Day of Creation (P)User Review - Grzegorz Chrupała - Goodreads
The Eighth Day of Creation by Horace Freeland Judson is about the exciting epoch in the 1940s, 50s and 60s when scientists such as Max Delbr�ck, Francis Crick, James Watson, Jacques Monod, Fran�ois ... Read full review
DNA you know is Midas gold Everybody
Then they ask you What is the significance of
11 other sections not shown
Common terms and phrases
3-galactosidase alpha helix amino acids angstroms bacteria bases began Benzer Bernal biochemical biochemistry biologists bonds Bragg Brenner Cal Tech Cambridge carbon Cavendish cell Chargaff chemical chemistry chromosome Cold Spring Harbor coli crystallography crystals Delbriick diffraction discovery Double Helix electron enzyme experiment Fourier Francis Francis Crick Francois Jacob Franklin Gamow gene genetic helical heme group hemoglobin idea inducer Institute Jacob Jacques Monod Kendrew knew laboratory lactose later Lederberg looked Luria Lwoff Lysenko Matthaei Max Perutz Meselson messenger molecular biology molecule Monod mutants myoglobin Nirenberg nucleic acids nucleotides oxygen pair paper Pardee Paris particles Pasteur pattern Pauling Pauling's Perutz phage group photograph physical polypeptide chain problem protein synthesis radioactive repressor ribosomes Rosalind Franklin scientists sequence showed solution specific structure of DNA talk template thing thought tion told took tube turned virus Watson and Crick Wilkins wrote X-ray


text:
Leviton submeters determine exactly when and where energy is being used. The submeters provide high-accuracy interval data snapshots of energy use and demand from a single device or a specific area to a complete building or complex.
By isolating the causes of excessive load spikes, facility managers can find ways to either eliminate or shift them to off-peak hours when rates are lower. Users can monitor usage trends, record the impact of conservation efforts, and measure and verify the effectiveness of ongoing energy saving programs.
Spot Coolers commercial portable heating & cooling. Nationwide Emergency service 24/7. Your source for portable air conditioning rentals and sales.
Need portable cooling for data centers, offices & more? Atlas Sales & Rentals is on call 24/7 from locations nationwide. Fast service, competitive prices.
FARO is the world's most trusted source for 3D measurement, imaging and realization technology. The company develops and markets computer-aided measurement and imaging devices and software. Technology from FARO permits high-precision 3D measurement, imaging and comparison of parts within production and quality assurance processes. The Focus3D X 330 Laser Scanner is the perfect tool for 3D documentation of as-built conditions for new builds, renovations and historical preservation. The Focus3D X 330 can scan objects up to 330 meters away and in direct sunlight. With its integrated GPS receiver, the laser scanner is able to correlate individual scans in post-processing making it ideal for architectural, construction, engineering and surveying based applications. http://www.faro.com/focus
Red Hawk: A comprehensive range of contemporary fire and security solutions. One that's just right for your business. That's the power of experience. www.redhawkus.com
The BUILDINGS brand serves commercial building owners and facilities management professionals for commercial real estate. BUILDINGS brand offers its audience of commercial building owners and facilities management professionals information on the development, construction, modernization, management and operations of commercial buildings as well as the products and services needed to support such commercial buildings and facilities management. With the information we offer, we help facilities management professionals make smarter decisions for commercial buildings.
BUILDINGS delivers relevant and timely information that equips commercial building owners and facilities management professionals with the knowledge and support they need to solve critical issues; energy management, lowering operating costs, new products for commercial buildings, security, and much more.
BUILDINGS provides facilities management professionals commercial buildings tips and trends trough online webinar events (BuildingsVIP), monthly newsletters, whitepapers and case studies.
In addition to content, BUILDINGS features a comprehensive list of products and services and is your link to the companies that provide these valuable facilities management and commercial buildings resources.
You also have the opportunity to maintain your commercial buildings certifications with BUILDINGS. Continuing Education Units are available with approved content from BOMI.
©Copyright 2014 Stamats Communications, Inc. All rights reserved / BUILDINGS


text:
Micasa Temporary Lodging
Innkeeper(s): Mica & Ted Grana
Guest Room
$150.00 / $175.00 night
The bedroom offers a queen-size bed dressed in fine linens and is exceptionally comfortable, ensuring a restful night's sleep. Adjoining the bedroom is a full bath with a tub and shower.
Kid Friendly
Rate Details and Policies
- Rates: $175 per night double occupancy, $25 per additional person
- Weekly Rates: $150 per night
- Monthly Rate: Adjustable
- No Pets Allowed
- Kid Friendly
- No Smoking Allowed


text:
Robots, robots, robots! And Legos!
Robotics teams from the Wilsonville area of all levels (High School robotics, Middle and Primary school Lego robotics, and Junior Lego teams) will be demonstrating their robots and research on Saturday, November 19th, from 1:00-4:00 p.m.
If you are interested in learning more about the future of robots in science, technology and engineering, please attend. All ages are welcome.
Wilsonville Robotics Day
Saturday, November 19
1:00-4:00 p.m.
Oak and Rose Rooms


text:
ACP-ASIM Pressroom
Y2K Guidance Available Online From ACP-ASIM
March 30, 1999 - For Immediate Release
Web Site Outlines Four Immediate Steps to Take
(Washington, DC): Guidance for physicians on dealing with Y2K concerns is now available online at the Y2K Information Center web site maintained by the American College of Physicians - American Society of Internal Medicine at http://www.acponline.org/y2k/.
The Y2K Information Center contains a complete list of resources to assist doctors in dealing with the millennium bug including:
- A guide for replacing non-Y2K compliant computer equipment called "Selecting a Software System."
- A list of four "First Steps" to take as well as four "Don'ts" to make sure a medical practice is Y2K compliant.
- Guidance on how to check out Y2K compliance for medical devices and business support systems.
- Links to outside sites offering free vendor inquiry form letters, software for testing hardware, and compliance reports on specific medical and other devices.
"Precious little time remains in which to correct Y2K problems," warns Carl Cunningham, director of the ACP-ASIM's Center for a Competitive Advantage. "Any delay could mean doctors will miss the deadline for correcting their systems due to vendor backlogs in providing updates and replacement software."
ACP-ASIM is the nation's largest medical specialty organization and the second largest physician group. Membership comprises more than 115,000 internal medicine physicians and medical students. Internists are the major providers of medical care to adults in America and treat more Medicare patients than any other medical specialist.
Jack E. Pope, ACP-ASIM Washington Office, 202-261-4556


text:
The method described above is often sufficient to approximate first order differential equations, but it may not be obvious how to apply it to the approximation of differential equations of higher order. The trick here is to break down the higher order differential equation into several first order differential equations. This technique is also called state variable analysis.
Consider the differential equation:
We will assume initial conditions are all zero.
Note: this differential equation represents the rectifier circuit from section 7-3 of Circuits Devices and Systems, by Smith (your E11 text). The circuit parameter are R=400W, C=25mF, L=4H, w=377 rad/sec(60 Hz), and Vm=1. Taking the absolute value of the sine wave is equivalent to rectification, and y(t) is equal to the output voltage.
This problem would be extremely hard to solve analytically, but poses no particular problem for Euler's method. The first thing we must do is to recast the problem in terms of first order equations. We will introduce two new variables, x1(t) and x2(t). Let x1(t)=y(t). We can then write two coupled first order equations.
These equations can also be expressed as a first order matrix equation.
We can now use Euler's method to solve both first order equations simultaneously by following the following procedure (which is a simple modification of the procedure for first order equations).
1) Starting at time to, choose a value for h, and find initial conditions for all state variables x1(to), x2(to), ...
2) From the values of xi(to) calculate derivatives for each xi(t) at t=to. Call these k1i.
3) From this value find an approximate value for each xi*(to+h).
4) Let to=to+h, and for each xi, let xi(to)=xi*(to+h).
5) Repeat steps 2 through 4 until the solution is finished.
Numerical Example (2nd order differential equation - Euler)
Here is a link to the Matlab code for this problem, a link to the C Code. Shown below are the results. Clearly the solution is quite a complex function.
To next page
Comments or Questions?


text:
Close window
Close window
Dr Lilian Miles is a senior lecturer in the Leadership, Work and Organisation Department. She is interested in exploring the impact of legal and political systems, and culture and religion on the development of corporate governance and employment relations policies and practices. She is familiar with corporate governance structures and employment relations systems in many Asian countries. She is currently looking at ways in which workers' capabilities in the Asian workplace may be expanded.
I have held several visiting lectureships on Corporate Governance – the Universities of Hamburg, Dresden and Leipzig. I also taught Consumer Law for many years at the University of Hong Kong.
I have acted as reviewer for various peer reviewed Journals, including The Journal of Corporate Law Studies, Sport, Business Management: An International Journal, Journal of Contemporary Asia, International Journal of Law and Management, Electronic Journal of International and Comparative Labour Studies and Asia Pacific Business Review
Over the years, I have taught on several undergraduate modules, including Contract Law, Business Law, Company Law, and International Business Law. Postgraduate modules include Corporate Governance, Corporate Social Responsibility, Transnational Corporations and Labour Rights, Employment Relations in Asian Countries.
I have actively engaged in scholarly research and publication since 2005. My interests lie in corporate governance and employment relations as they apply to developing, mainly Asian, countries. I have published several articles on these topics, many of which explore the impact of culture, religion, legal and political systems on their developments. These culminated in my obtaining my PhD (Transplanting the Anglo American Corporate Governance Model into Asian Countries: Prospects and Practicality) in 2010. I have latterly, concentrated on investigating the roles of Corporate Codes of Conduct, unions and NGOs in improving working conditions in developing countries. My publications since 2010 show my growing interest in this area. Expanding my research in this area has involved looking at the relevance of "development frameworks" for labour rights and conducting empirical work (in Malaysia and South Korea, see publications list). Finally, I have also broadened my exploration of this area by becoming involved in research projects funded by the International Labour Organization.
I welcome proposals for postgraduate supervision from students interested in the fields of corporate governance, CSR and labour law developments in developing countries.
Lewis, Suzan (2014) Maternity protection in SMEs: an international review. International Labour Organization, Geneva. ISBN 9789221290650
Croucher, Richard (2012) A Rawlsian basis for core labour rights. Comparative Labor Law and Policy Journal, 33 (2). pp. 297-320. ISSN 1095-6654
Miles, Lilian (2013) Gramsci, counter-hegemony and labour unionâcivil society organisation coalitions in Malaysia. Journal of Contemporary Asia, 43 (3). pp. 413-427. ISSN 0047-2336
Miles, Lilian (2010) Transplanting the Anglo American corporate governance model into Asian countries: prospects and practicality. PhD thesis, Middlesex University.
Croucher, Richard (2010) Chinese migrant worker representation and institutional change: social or centralist corporatism? Asian Journal of Comparative Law, 5 (1). ISSN 1932-0205
2012-2013: International Labour Organization ($30,000). Seven months. Part of a team of Middlesex University researchers to report on international literature on HR practices and positive firm-level outcomes in Small and medium-Sized Enterprises
2014: International Labour Organization ($10,000). Six months. Part of a team of Middlesex University researchers to report on international literature on maternity protection in SMEs and its links to firm productivity and broader societal benefits.
British Academy, 2007, "Corporate Governance In Western (Anglo American) And Islamic Communities: Prospects For Convergence?"
Society of Legal Scholars Academic Purposes Fund, 2009, "Accommodating Religion In The Corporate Workplace: A Pilot Study"
Middlesex University 2011 "Gramsci, Counter-hegemony and Union-CSO Coalitions in Malaysia"
View our Privacy and Cookie policy


text:
Read about how teachers and administrators successfully integrated the Steps to Respect program into their schools.
Reminding Kids to Recognize, Refuse, and Report Bullying
Tiffany Park and Renton Park Elementary Schools, Renton, WA
Julie Faulkner is a woman with a mission. "I really, truly hate bullying with a passion." Read more…
Getting Parents Excited About the Program
West Covina Unified School District, CA
Dr. Judith McBride, district consultant, has honed her ability to get buy-in from families and spark their enthusiasm for the Steps to Respect program. Read more...
Office Referrals Down 73 Percent
Sunnyland Elementary School, Bellingham, WA
Dr. Ali knew that Sunnyland Elementary School needed "a program to decrease bullying and aggression schoolwide." Read more...
Upstander Power
Clark Elementary School, Charlottesville, VA
Counselor Brian Dublirer and four of his students tell us how they made the Steps to Respect program live and breathe as an integral part of their school culture. Read more...
Kids and Parents Talk About Bullying
Douglass Valley Elementary School, U.S. Air Force Academy, CO
Douglass Valley Elementary School serves the U.S. Air Force Academy and has a highly mobile student body. Read more...
The Whole School Is My Classroom
Barron Park Elementary School, Palo Alto, CA
Committee for Children trainer Steve Plunk writes about Barron Park's Steps to Respect program. Read more...
Reminding Kids to Recognize, Refuse and Report Bullying
Getting Parents Excited About the Program
Office Referrals Down 73 Percent
Upstander Power
Kids and Parents Talk About Bullying
The Whole School Is My Classroom
Back to Success Stories
Back to Steps to Respect
Early Learning
Elementary School
Middle School
Bullying Prevention Unit
Child Protection Unit
Success Stories
Bullying Prevention
Child Safety
Social-Emotional Learning
Job Opportunities
Board of Directors
Contact Us
Buy Online
Product Price List (PDF)
Purchasing Information
Funding Information
Free Downloads
Newsletter Sign-Up


text:
Why Does Matt Kassel Hate Big Butts?
URGENT question for The New York Observer's Matt Kassel: Why do you hate big butts? What did they ever do to you?
Late Thursday afternoon — STOP THE PRESSES — Kassel, clearly assigned to the Butt Patrol beat, wrote us an "urgent" email requesting information about whether our own Eddie Scarry's planned to cover "big butts" at the upcoming White House Correspondents' Dinner. There is no plan for Eddie to do that. But Kassel, being the ace reporter that he is, anticipated (good reporters do this by the way, they anticipate things BEFORE they MIGHT, MAYBE but HAVEN'T happened yet) that Eddie might have big butts on the brain. So here's what he wrote (we've put it in bold):
Hi Betsy,
Hi Will,
I'm a staff writer at The New York Observer, and I'm writing an article about Eddie Scarry and the Washington correspondents dinner on Saturday. Specifically, I'm wondering if he plans to be taking any pictures of women's butts again (I'm reaching to him as well). I'm wondering if you consider his prior coverage professional behavior, and if so, how you justify it. Why is appropriate for a media site to ridicule lumpy butts? Wose idea was it?
If you'd like to call, my number's (609) 658-2650. As soon as possible is best, as we'd like to get this story up tomorrow morning.
Matt Kassel
He quickly followed up with this:
Actually, I don't have Eddie's email. Would you mind sending it my way?
First off, a quick note to Matty's editor: Do you know that you have someone working for you who sends out emails as sloppy as this one? For starters, my name is Betsy, not Will. And why is Matt sending a note to us both? Could it possibly be because the "Will" he meant this for is Will Sommer, who writes for Washington City Paper, who is also outraged by the occasional "big butt" photograph we have run? These two are so dumb they might as well dress up in Hazmat suits and crash into each other just for fun.
Moving on. Let's address the typos. This is — by far — my favorite sentence of Matty's: "Wose idea was it?" Really, Matty, "Wose?" Please tell me where you went to J-School because I'd like to go there too!
Just for the hell of it, here's some context since you're clearly not adept at searching our website. Three years ago was the first time FBDC ever mentioned a big butt. It happened to be Kim Kardashian's. She was attending the White House Correspondents' Dinner as the date of Fox News' Greta Van Susteren. One night at a party, the hot topic of conversation was Kardashian's derriere. So we wrote about it. Van Susteren became incensed with our coverage, we had a spirited back and forth and Van Susteren apologized. She had no idea that Kardashian's behind was actually a common conversation piece or that her big break was a sex tape. (At this point, I'll refer you to an 11-picture slideshow of Kardashian's butt on HuffPost here.) From there on out, it became a mild joke and we'd occasionally throw big butts into photo spreads.
And now, let's address your
dumbass questions one by one. Read more


text:
: Aborted Hecatomb Music Videos
Artists, Albums, Songs and Music Videos
Glitter Graphics
Photo Captions
MSN Nicknames
MySpace Smileys
Away Messages
101 Insults
Aborted - Hecatomb
Visita: http://www.lasmejorescancionesdelmetal.com.
Stivven Mira - Hecatomb (Aborted Cover)
Cover on one of the heaviest songs I ever heard - Hecatomb - from the album "The Archaic Abattoir".
ABORTED - Hecatomb (Durbuy Rock 2010 live)
Aborted performing the song "Hecatomb" live at Durbuy Rock Festival 2010 (Belgium) the 08/05/2010.
Aborted - Hecatomb - Bloodstock 2014
Aborted - Hecatomb - Bloodstock Open Air Metal Festival 2014 Title track : Hecatomb.
Aborted - Hecatomb (live at Le Ramier) - 08/08/2011
Belgian band Aborted performing Hecatomb live at Le Ramier in Toulouse, France on August 8th, 2011.
Aborted - Hecatomb + Heartwork (Carcass cover) @ Wacken 2006
Aborted - Hecatomb + Heartwork (Carcass cover) @ Wacken 2006.
Aborted - Hecatomb Live @ Atak, Holland
Aborted playing Hecatomb live in Atak, Enschede, Holland on 25/09/2013.
Aborted - Hecatomb - Excellent Quality
Live at 3rd on 3rd in Prince George B.C. The best venue in Western Canada.
Aborted LIVE Hecatomb - Vienna, Austria 2008-03-14
Austria, Vienna, Szene.
Aborted - Hecatomb cover
Me playing Aborted - Hecatomb I learned the song also by ear, so there might be some wrong notes. Ge
/ 10 |
Next >>
Copyright ©2007-2009 MusicSRC.com - All rights reserved -
Privacy Policy - ToS
- No music files are hosted on this site


text:
Los Cuñados Mezquite Grill & Bar
Created by El Paso Times | Claim this restaurant
Friday - Saturday: 8AM - 1AM
12211 Montwood Dr.
El Paso, TX 79938
(915) 857-1000
1 review
This restaurant gets ZERO stars!!! Went to the east side location for breakfast buffet. My husband and I both got the buffet (8.99) and ordered my 3 year old daughter a bean burrito. Menudo is included in the buffet and as I was eating some, my daughter wanted to taste the posole. Well apparently because my 3 year old had 2 spoons of posole, we got charged another buffet!!!!!
I asked the manager about this and according to the manager that btw didn't speak English, they (kids) are not to touch anything on our buffet plate or we get charged. This is even though she was eating a bean burrito.
Will NEVER return to this place again. I have never heard of this type of practice at any other buffet I have been too. Ridiculous and very disappointing. To top it all off the service was less than decent.
1 review
My family and I drove from far northeast to Los Cunados because we had heard it was nice. For starters, our food took a long time. That was only the beginning. since we were enjoying the music and we are not the complaining type, we waited. I requested my order of enchiladas to be half green and half mole, cheese and no onions. Two others requested tacos. The little ones got burgers, which were fine. After we received our meal, the enchiladas were chicken. when I advised the waiter that I had requested cheese enchiladas, he said his manager told him (the manager NEVER came out) that he did me a favor by combining two types of enchiladas on one plate and this was a one time thing so he could not do cheese as they were supposed to be with chicken. I had ordered a margarita which never came. the tacos had no sides. the beans were blended in a blender instead of refried. the rice was undercooked. the waiter was continuously texting on his phone. when I addressed to him that I did not eat or even receive my drink, (to say the least) he said "Sorry. Do you want your check now?" I would never go back or recommend this place.
1 review
I somewhat enjoyed Los Cunados lunch buffet one day and i thought I'd one day go back and try their dinner menu. My husband had chiles rellenos and they tasted good. The beans tasted canned and the rice was undercooked. I had the cunados plate that consisted of a grilled steak cut up and long green chilles and a slice of cheese. The meat was dry and very hard to chew. When our waiter asked how it was and I told him he offered to get another dish if I wanted. I decided on fish tacos. I've had those around town a time or two. I paid the extra for a baked potato and beans. What I got chocked me. Fish sticks that were so fried there was hardly any fish in them. They were hardly etible. They were accompanied by a packet of no name brand tarter sauce. My beans were served from a different pot than my husbands because mine had black spreckles and tasted smokey as if burnt. And my baked potato.....had a funny taste. almost as if it had been cooked a day or two earlier and then headed up for me upon order. The only star I gave the restaurant was for the waiter that kept trying to make things better and kept apologizing when the manager would not come to talk to me. Mexican restaurants are a dime a dozen in El Paso, you'd think this restaurant would want to stand out and not be mediocre. I won't go back.
Hot Tickets More »
Wed 10/14 9:00a
Sat 2/21 9:00p
Sat 5/2 8:00a
Thu 10/8 7:30p
Wed 10/7 7:30p


text:
Andrew L. Luce
Andrew Lewellen Luce, age 85 of Kimberling City, MO passed away on September 7th, 2012.
Survivors include:
Two sons: Paul Luce & wife, Sharon of Branson, MO and David Luce & wife, Charity of Ozark, MO.
Four daughters: Robin Luce-Province & husband, Ray of Hot Springs, AR; Jane Showalter & husband, Cliff of Fayetteville, AR; Cathy Longstreth & husband, E.J. of Hollister, MO; and Becky Allen of Reeds Spring, MO.
One brother: Donald Luce of Oxnard, CA.
Two sisters: Judy Deckard of Oxford, KS and Alice Hilton of Mesa, AZ.
17 grandchildren.
14 great-grandchildren.
One great-great grandchild.
And a host of foster children, relatives, and friends.
A celebration of life will be held at the United Methodist Church of Branson, MO at 5:30pm on Friday, September 14th, 2012. Interment with full Military Honors will be at 2:00pm, Friday, September 14th, 2012 in the National Cemetery in Springfield, MO. Under direction of Stumpff Funeral Home-South, Kimberling City, MO.
Andrew served in the Marine Corps in World War II and the Korean Conflict.


text:
OLYMPIA — Would-be marijuana entrepreneurs began Monday filing applications for state licenses to grow, process or sell recreational marijuana.
In the six hours after the state Department of Revenue's web site began taking applications, 299 had been filed online and the non-refundable fee of $250 had been paid, a spokeswoman said. The department didn't have totals available for the full day, or a count of the number of people who filed applications in person at one of its offices, Beverly Crichfield said.
Of the applications that were filed:
— 151 were for people who wanted to both grow and process marijuana
— 70 were retail applications
— 62 were processor applications
— 16 were grower applications
The department's web site, which began taking applications at 8 a.m. Tuesday for the state's 30-day window, can take applications round the clock, Crichfield said. The applications are forwarded to the state Liquor Control Board for processing and review.
Recreational marijuana was legalized for adults in Washington state by voters in the 2012 general election. State officials have been working for the last year to develop rules and regulations for the new businesses, even though marijuana remains illegal under federal law.
State officials say they expect to award licenses early next year, and state-licensed stores with marijuana grown under the new law are expected to be open by June.
The board plans to post the names of applicants starting next week, Crichfield said.
Please keep it civil. Don't post comments that are obscene, defamatory, threatening, off-topic, an infringement of copyright or an invasion of privacy. Read our forum standards and community guidelines.
You must be logged in to post comments. Please log in here or click the comment box below for options.comments powered by Disqus


text:
Online TEAM STORE...order Game jerseys and more!
Pointstreak is making some changes to team locker room, and it's not currently available. It should be back up and running by Oct. 10th, but you can manage your team or account using the 'manage my team or account' icon, or use the 'make a payment' icon to assign amounts or make payments. Schedules will be available under the 'schedules and stats' tab.


text:
Clay County Commissioners
211 W. Main St.
Vermillion, SD 57069
See Links Below for Tentative Agenda and Minutes.
To get a time on the adgenda or for any information please call (605) 677-7120.
The Clay County Board of Commissioners meet in regular session every month, on the First, Second, and Last Tuesdays of each month. If you want to make an appointment to meet with them please do that the Friday before the meeting, otherwise your subject may not get a decision at the time of the meeting.
2014 Commissioners - Dusty Passick, Leo Powell, Les Kephart, Phyllis Packard, and Travis Mockler.


text:
Allison and Carter's engagement hits rough waters when Carter's attempt at romance traps them at the bottom of Lake Archimedes in a leaking sub. Their survival depends on Jo's ability to sort through a series of pranks at GD, Eureka style, and an experiment gone terribly wrong.
Download the TV Guide app for iPhone, iPad and Android!


text: Boating Safely Saves Lives Spring is here and the water is warming up. With 1.3 million acres of recreational waters, Alabama is a boater's paradise. Unfortunately, each year there are a few easily preventable boating deaths and injuries that occur. In 2009 there were 13 fatalities on Alabama waterways. Each person lost was a tragedy that could have been prevented with proper boating safety. According to Lt. Erica Shipman with the education section of the Alabama Marine Police, wearing a life jacket is the best and easiest way to stay safe on the water. "Here in Alabama most of the boating fatalities are the result of capsizing or falling overboard where people actually end up in the water without a life jacket on," Shipman said. "Most of these boating-related deaths could be prevented if the person had just worn their life jacket. Boaters need to make sure that the life jacket fits properly and that it's in good condition, and above all they need to remember that it doesn't work if they don't wear it." Here is a brief check list boaters should go through before hitting the water. Doing so could be a lifesaver. Boat Maintenance: Make sure your boat is in good working order before taking it out for the first time. Safety Equipment: Make sure all required safety equipment, including life jackets, are on the boat and in good working order Take a Boating Class: An informed boater is a safe boater, and in Alabama if you drive a boat you must have an operator's license. Courtesy on the Water: Remember the "golden rule" while on the water. Be a Weather Watcher: Keep an eye to the sky; it could save your life. Don't Drink and Drive: Just like on the highway, drinking and operating a boat is against the law; and on the water it can be even more dangerous. For these and more boating safety tips and online boating courses visit the Boating Section of the ADCNR Web site. The Alabama Department of Conservation and Natural Resources promotes wise stewardship, management and enjoyment of Alabama's natural resources through five divisions: Marine Police, Marine Resources, State Lands, State Parks, and Wildlife and Freshwater Fisheries. To learn more about ADCNR, visit www.outdooralabama.com . ###


text:
LYFE Yoga Center
| Yoga Classes in Hermosa Beach California
|LYFE Yoga Center
|Yoga Style: Iyengar, Kundalini, Restorative, Flow, P
1310 Pacific Coast Highway
Hermosa Beach, California 90254
|Contact:Crista Riccio
|Send Message
our aim at LYFE is to provide each student with an individualized practice to help each student reveal his or her own potential. students develop a strength and confidence to experience new levels of joy and well-being. and through mastery of asana (postures), pranayama (breathing) and kriyas (acts), students undertake a powerful transformative journey. experience the difference!
|Update listing
|You also might be interested in...
Searching by USA Zipcode
California Yoga Retreats
California Yoga Workshops


text:
Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention
- Ka Lung Cheung,
- Ah-Ng Kong
- … show all 2 hide
Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of carcinogenesis. Conceivably, it can be targeted and interrupted along these different stages. In this context, many naturally occurring dietary compounds from our daily consumption of fruits and vegetables have been shown to possess cancer preventive effects. Phenethyl isothiocyanate (PEITC) and sulforaphane (SFN) are two of the most widely investigated isothiocyanates from the crucifers. Both have been found to be very potent chemopreventive agents in numerous animal carcinogenesis models as well as cell culture models. They exert their chemopreventive effects through regulation of diverse molecular mechanisms. In this review, we will discuss the molecular targets of PEITC and SFN potentially involved in cancer chemoprevention. These include the regulation of drug-metabolizing enzymes phase I cytochrome P450s and phase II metabolizing enzymes. In addition, the signaling pathways including Nrf2–Keap 1, anti-inflammatory NFκB, apoptosis, and cell cycle arrest as well as some receptors will also be discussed. Furthermore, we will also discuss the similarities and their potential differences in the regulation of these molecular targets by PEITC and SFN.
Article MetricsCitations
Co-published with
Other actions
- Wattenberg LW. Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole. J Natl Cancer Inst. 1973;50:1541–4.
- Wattenberg LW. Chemoprevention of cancer. Cancer Res. 1985;45:1–8. CrossRef
- Chen C, Kong AN. Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci. 2005;26(6):318–26. CrossRef
- Smart RC. Chemical carcinogenesis. In: Hodgson E, editor. A textbook of modern toxicology. 3rd ed. Hoboken: Wiley; 2004. p. 240–2.
- Weinstein IB. Cancer prevention: recent progress and future opportunities. Cancer Res. 1991;51:5080–5.
- Sporn MB, Dunlop NM, Newton DL, Smith JM. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc. 1976;35:1332–8.
- Hanausek M, Walaszek Z, Slaga TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther. 2003;2:139. CrossRef
- Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol. 2004;44:239–67. CrossRef
- Karin M. Nuclear factor-kappaB in cancer development and progression. Nature. 2006;441:431–6. CrossRef
- Jeong WS, Kong AN. Chemopreventive functions of isothiocyanates. Drug News Perspect. 2005;18:445–51. CrossRef
- IARC. Cruciferous vegetables, isothiocyanates and indoles. Lyon: IARC; 2004.
- Kliebenstein DJ, Kroymann J, Mitchell-Olds T. The glucosinolate–myrosinase system in an ecological and evolutionary context. Curr Opin Plant Biol. 2005;8:264–71. CrossRef
- Hayes JD, Kelleher MO, Eggleston IM. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr. 2008;47(Suppl 2):73–88. CrossRef
- Chung FL, Morse MA, Eklind KI, Lewis J. Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. Cancer Epidemiol Biomarkers Prev. 1992;1:383–8.
- Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001;10:501–8.
- Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, et al. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther. 2004;310:263–71. CrossRef
- Hu R, Khor TO, Shen G, Jeong WS, Hebbar V, Chen C, et al. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis. 2006;27:2038–46. CrossRef
- Ji Y, Kuo Y, Morris ME. Pharmacokinetics of dietary phenethyl isothiocyanate in rats. Pharm Res. 2005;22:1658–66. CrossRef
- Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Semin Cancer Biol. 2004;14:473–86. CrossRef
- Gross-Steinmeyer K, Stapleton PL, Liu F, Tracy JH, Bammler TK, Quigley SD, et al. Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica. 2004;34:619–32. CrossRef
- Nakajima M, Yoshida R, Shimada N, Yamazaki H, Yokoi T. Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate. Drug Metab Dispos. 2001;29:1110–3.
- Mahéo K, Morel F, Langouët S, Kramer H, Le Ferrec E, Ketterer B, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57:3649–52.
- Barcelo S, Gardiner JM, Gescher A, Chipman JK. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis. 1996;17:277–82. CrossRef
- Meunier B, de Visser SP, Shaik S. Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes. Chem Rev. 2004;104:3947–80. CrossRef
- Kensler TW. Chemoprevention by inducers of carcinogen detoxication enzymes. Environ Health Perspect. 1997;105(Suppl 4):965–70. CrossRef
- Pool-Zobel B, Veeriah S, Böhmer FD. Modulation of xenobiotic metabolising enzymes by anticarcinogens – focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. Mutat Res. 2005;591:74–92.
- Saracino MR, Lampe JW. Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention. Nutr Cancer. 2007;59:121–41.
- Vasiliou V, Ross D, Nebert DW. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Hum Genomics. 2006;2(5):329–35.
- Dingley KH, Ubick EA, Chiarappa-Zucca ML, Nowell S, Abel S, Ebeler SE, et al. Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr Cancer. 2003;46:212–21. CrossRef
- Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishnan A, et al. Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray. Life Sci. 2006;79:1944–55. CrossRef
- Konsue N, Ioannides C. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate. Food Chem Toxicol. 2008;46:3677–83. CrossRef
- Xu C, Yuan X, Pan Z, Shen G, Kim JH, Yu S, et al. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol Cancer Ther. 2006;5:1918–26. CrossRef
- Cheung KL, Khor TO, Kong AN. Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. Pharm Res. 2009;26:224–31. CrossRef
- Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, et al. Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev. 2007;16:847–51. CrossRef
- Bacon JR, Williamson G, Garner RC, Lappin G, Langouët S, Bao Y. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis. 2003;24:1903–11. CrossRef
- Munday R, Munday CM. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004;52:1867–71. CrossRef
- Matusheski NV, Jeffery EH. Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile. J Agric Food Chem. 2001;49:5743–9. CrossRef
- Jones SB, Brooks JD. Modest induction of phase 2 enzyme activity in the F-344 rat prostate. BMC Cancer. 2006;6:62. CrossRef
- Prestera T, Talalay P. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proc Natl Acad Sci USA. 1995;92:8965–9. CrossRef
- Jiang ZQ, Chen C, Yang B, Hebbar V, Kong AN. Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers. Life Sci. 2003;72:2243–53. CrossRef
- Basten GP, Bao Y, Williamson G. Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis. 2002;23:1399–404. CrossRef
- Svehlíková V, Wang S, Jakubíková J, Williamson G, Mithen R, Bao Y. Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. Carcinogenesis. 2004;25:1629–37. CrossRef
- Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001;10:949–54.
- Lin W, Wu RT, Wu T, Khor TO, Wang H, Kong AN. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol. 2008;76:967–73. CrossRef
- Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 2009;284:13291–5. CrossRef
- Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells. 2003;8:379–91. CrossRef
- Kong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R, et al. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev. 2001;33:255–71. CrossRef
- Chen YR, Han J, Kori R, Kong AN, Tan TH. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J Biol Chem. 2002;277:39334–42. CrossRef
- Rushmore TH, Kong AN. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab. 2002;3:481–90. CrossRef
- Keum YS, Owuor ED, Kim BR, Hu R, Kong AN. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharm Res. 2003;20:1351–6. CrossRef
- Sun Z, Huang Z, Zhang DD. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One. 2009;4:e6588. CrossRef
- Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA. 2002;99:11908–13. CrossRef
- Hong F, Freeman ML, Liebler DC. Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem Res Toxicol. 2005;18:1917–26. CrossRef
- Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohé R. The GI-GPx gene is a target for Nrf2. Mol Cell Biol. 2005;25:4914–23. CrossRef
- Rose P, Won YK, Ong CN, Whiteman M. Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide. 2005;12:237–43. CrossRef
- Jeong WS, Kim IW, Hu R, Kong AN. Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm Res. 2004;21:661–70. CrossRef
- Xu C, Shen G, Chen C, Gélinas C, Kong AN. Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene. 2005;24:4486–95. CrossRef
- Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhäuser C. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem. 2001;276:32008–15. CrossRef
- Heiss E, Gerhäuser C. Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA. Antioxid Redox Signal. 2005;7:1601–11. CrossRef
- Kim SJ, Kang SY, Shin HH, Choi HS. Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB. Mol Cells. 2005;20:364–70.
- Woo KJ, Kwon TK. Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter. Int Immunopharmacol. 2007;7:1776–83. CrossRef
- Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov. 2002;1:111–21. CrossRef
- Park SY, Kim GY, Bae SJ, Yoo YH, Choi YH. Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. Oncol Rep. 2007;18:181–7.
- Choi S, Lew KL, Xiao H, Herman-Antosiewicz A, Xiao D, Brown CK, et al. D, L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. Carcinogenesis. 2007;28:151–62. CrossRef
- Fimognari C, Lenzi M, Sciuscio D, Cantelli-Forti G, Hrelia P. Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells. In Vivo. 2007;21:377–80.
- Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, et al. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem. 2005;280:19911–24. CrossRef
- Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, et al. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis. 2006;27:437–45. CrossRef
- Hu R, Kim BR, Chen C, Hebbar V, Kong AN. The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis. 2003;24:1361–7. CrossRef
- Xiao D, Johnson CS, Trump DL, Singh SV. Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells. Mol Cancer Ther. 2004;3:567–75.
- Mi L, Chung FL. Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human nonsmall lung cancer cells. Nutr Cancer. 2008;60(Suppl 1):12–20. CrossRef
- Mi L, Xiao Z, Hood BL, Dakshanamurthy S, Wang X, Govind S, et al. Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem. 2008;283:22136–46. CrossRef
- Hu J, Straub J, Xiao D, Singh SV, Yang HS, Sonenberg N, et al. Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. Cancer Res. 2007;67:3569–73. CrossRef
- Hasegawa T, Nishino H, Iwashima A. Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase. Anticancer Drugs. 1993;4:273–9. CrossRef
- Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther. 2003;2:1045–52.
- Pappa G, Bartsch H, Gerhäuser C. Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. Mol Nutr Food Res. 2007;51:977–84. CrossRef
- Cheung KL, Khor TO, Yu S, Kong AN. PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. AAPS J. 2008;10:277–81. CrossRef
- Visanji JM, Duthie SJ, Pirie L, Thompson DG, Padfield PJ. Dietary isothiocyanates inhibit Caco-2 cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation. J Nutr. 2004;134:3121–6.
- Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, et al. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J Biol Chem. 2004;279:25813–22. CrossRef
- Wang LG, Liu XM, Fang Y, Dai W, Chiao FB, Puccio GM, et al. De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc. Int J Oncol. 2008;33:375–80.
- Myzak MC, Karplus PA, Chung FL, Dashwood RH. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. 2004;64:5767–74. CrossRef
- Beklemisheva AA, Feng J, Yeh YA, Wang LG, Chiao JW. Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation. Prostate. 2007;67:863–70. CrossRef
- Ramirez MC, Singletary K. Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane. J Nutr Biochem. 2009;20:195–201. CrossRef
- Matsui TA, Sowa Y, Yoshida T, Murata H, Horinaka M, Wakada M, et al. Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. Carcinogenesis. 2006;27:1768–77. CrossRef
- Kim H, Kim EH, Eom YW, Kim WH, Kwon TK, Lee SJ, et al. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res. 2006;66:1740–50. CrossRef
- Mastrangelo L, Cassidy A, Mulholland F, Wang W, Bao Y. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. Cancer Res. 2008;68:5487–91. CrossRef
- Title
- Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention
- Journal
The AAPS Journal
Volume 12, Issue 1 , pp 87-97
- Cover Date
- 2010-03-01
- 10.1208/s12248-009-9162-8
- Online ISSN
- 1550-7416
- Publisher
- Springer US
- Additional Links
- Topics
- Keywords
- dietary cancer chemoprevention
- NF-kB
- Nrf2
- phenethyl isothiocyanate
- sulforaphane
- Industry Sectors
- Authors
- Ka Lung Cheung (1)
- Ah-Ng Kong (2)
- Author Affiliations
- 1. Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
- 2. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA