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Chicago Fire Review: An Honorary Heroby Carissa Pavlica at . Comments
I was really torn which direction to take in my review of "A Coffin That Small."
There was a lot happenings at the firehouse and a lot of it will be relevant in coming weeks... but none of it really stands out against what I took away while I watched, as tears streamed down my face several times during the hour.
It's interesting that this particular episode was aired on the day NBC announced a possible spinoff series, based upon a Chicago police department, because I don't see how any show about the police could pack as powerful of a punch as one hour of Chicago Fire does. The biggest reason for this comes from something Herman said in this Chicago Fire quote:
We're not cops. People are happy to see a firefighter arrive. | permalink
The horrific nature of the first scene they were called to by the brother of a victim trapped in a laundry shoot just down the street from the firehouse set the tone for the entire episode. Upside down, his head at an unnatural angle making it difficult to breathe, we were already clued in by the title of the installment that he wasn't going to make it.
It shook everybody to their core, but even more so when they learned from the victim's mother one of his proudest moments had been when his class took a field trip to the firehouse. Upon his return home, he announced he would one day be a firefighter himself. She carried that memory with her because she knew his dream would always keep him away from the gangs so close on his heels, always trying to find a way to drag him in. Even at that young age, they come calling.
Mouch, Hermann and Boden attended a funeral for an old friend, a retired firefighter. On the way there, we got to learn a bit more about them. I never knew Mouch and Hermann grew up together. Hermann complained that he had lost touch with his older brother and father because they had a special bond he couldn't share since his brother followed his father into the sock business and he went his own route to be a firefighter. Mouch urged him to call his father, but the hurt of the un-returned call was more than he could bear.
They got to the funeral - and it was empty. Hermann was shocked. The man had family. He was a hero. Where was the truck? Where were his sons, the men to honor him? Another great quote:
He deserved a funeral with respect for all of his service, and just because he waited a dozen years to die and moved out to the sticks doesn't mean he wasn't a hero. | permalink
My own grandfather was a fire commissioner. He was retired, but remained active with his house until he died. I know the feeling you have when your loved one receives the honor of a heroes funeral. My grandfather didn't have a hearse, but rode on the back of a firetruck he restored. We rode past the house with the flag flying at half staff. To be a fireman and know what your friend had achieved, but see him so alone at the end must be very distressing. It certainly was to Hermann.
The next day they received the news that the little boy hadn't survived. His mother delivered his picture to the house, knowing he would want them to have it. He was dressed as a firefighter. Boden used it as a rally call to pull together and put all of their crap behind them. Once they saw him, it was easy to recall his smiling and excited face from the class trip. Everyone was touched.
Hermann decided to call his father, but his call wasn't returned. Mouch kept in better touch with Hermann's family than he did, so he took him over to the family business where his brother welcomed him with open arms. While Hermann's father was out of town, his brother took him into his office and showed him something he needed to see. An entire wall in dedication to his son, the firefighter. Framed newspaper articles, awards, family photos - apparently it was hard to shut him up about how proud he was. If Hermann hadn't been so afraid to make the call, he might have found out the same was true from his father.
In the last scene, as the local gang bangers stood around looking at the funeral procession driving by, a mother and a son looked out their window and saw an entire firehouse in full dress blues, flag flying at half staff, in a salute to their lost son. The boy who would never join a gang because he wanted to be a firefighter, and an honorary hero.
Firefighters change lives. They save them, provide safe haven when needed and don't pass judgement. In order to do their jobs, they must all support each other and work as a family. If they don't the unit starts to break. It's happening in Firehouse 51, but it it will still be happening next week, and those darker discussions can be saved for then. This week is about the good. The honor. The lifesaving.
I don't know how they can pull that off with a series about police, but I wish them the best.
Carissa Pavlica is the managing editor and staff writer for TV Fanatic. Follow her on Twitter and on Google+.Tags: Reviews, Chicago Fire
The Cardinals are tied for second in the NFC West with the 49ers, but why does this game feel like it will once again reveal the gap between San Francisco (and by extension, Seattle) and the rest of the division is significant. Perhaps that s because the 49ers have won seven of the past meetings in this series, and outscored the Cardinals by a 51-16 margin last year.
arizona cardinals nike uniforms http://www.webvidal.ru/Gastro/...
I thought this was the best and most touching episode of the Season. Was Hermanns Brother the actor who plays Archie from ONCE UPON A TIME? If not he is a dead ringer for him.
Very emotional closing scene. When Hermann said, "I have an idea", I thought we were going to see the engine in the funeral procession. Having the company line up outside the firehouse, in their dress uniforms, with the flag hanging down from the ladder, seemed to show even more respect for the little boy and his family. I was describing it to a co-worker this morning, and the tears started coming down again. Well done.
I don't understand why Severide was unable to believe Casey about Heather. "I know what I saw." What exactly did he see? Nothing. He saw Casey and heard Heather ask about mouthwash. Why in the world would he assume they were sleeping together from that? The rest of the episode was great. The last scene was heartbreaking and amazing.
Fire departments all over the country should be applauding this show...great public service in letting us know just what First Responders do,the risks they take, the compassion they show, and the respect we all should have for them.I feel I've learned so much since the Fall. I agree that Severide was out of line in regards to Casey. And Shay's description of what would take place with Severide....I was laughing outloud!
I'm not a person to get emotional enough for a tear but thischanged that because they showed anyone who would stay away from the pressures of gangs to be a firefighter deserve to be honered by those who would be his or her fellow firefighters
Love this episode and I am not going to lie but I did cry a little bit lol. As for cop shows my fix is rookie blue so another cop show lol anyway keep coming with good episodes thanks;)
I really love this show and it gets better and better each week. I don't know about the spin off either. We have enough cop shows. The only thing I like about the spin off is that maybe that means NBC will renew CF for next year. I tell all my girlfriends this is a great show because it has a man for every taste and it is a well written show. I think Severide likes Shay and I think Shay may like him because she gets jealous every time he is with another women. Shay girl you just don't know how many women would do plan "b" with Severide and enjoy it! I don't understand why Severide is so mad at Casey and doesn't believe Casey when he says there is nothing going on between him and Heather. I was crying at the end with the funeral for the little boy. It will be interesting to see what happens with the stupid drug fools. Herman quote: We're not cops. People are happy to see a firefighter arrive. Amen brother!
I love Casey but I think it was a little crazy to go talk to the gang members alone, first Voight now the gang members, I hope his luck getting out alive does not come to an end.
I also hope that the new paramedic is Shay's love interest too!
This show is so fantastic! Last night just solidified that even more!
The ending made me cry! I loved them all standing in their dress (blues/Black). That was such a great scene.
I also cried when Hermann went to his dad and brothers office. I really like Hermann, I am glad we saw a lot of him this week.
I like Severide but I wish he would ease up on Casey. He should take his word that he is not sleeping with Heather.
I loved all the scenes with Severide and Shay, I saw a little look of disappointment on his face when Shay said her dad would pay for the procedure and they would not have to sleep together.
I still like Mills and Dawson and I will not be happy if Dawson and Casey hook up.
I am looking forward to next week.


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Welcome to Floyd's Auto Sales - Your Stillwater Used Cars Lot. Floyd's Auto Sales is your Stillwater, MN Used Cars lot serving Saint Paul, Minneapolis and the surrounding areas
More people buy their Used Cars inventory from Floyd's Auto Sales than any other Used Cars lot in the MN region including . At Floyd's Auto Sales in Stillwater, MN we treat the needs of each individual customer with the utmost concern. We know that you have needs, and as a Used Cars lot we enjoy the challenge of meeting and going above your needs each and every time. Whether it's used cars for sale, used vehicles, usedcars, pre-owned cars you can easily search our Stillwater Used Cars inventory online by checking our Used Cars inventory online. If you don't see exactly what you need there, you can also fill out the simple online form in our CarFinder and we will locate what you're looking for and contact you when we do. It's simple, quick and easy. If it's Used Cars inventory you're in the market for, Floyd's Auto Sales has you covered as well. Check our used cars for sale, used vehicles, usedcars, pre-owned cars website to get all the details of what we have in stock or you can also use the CarFinder for searching Used Cars inventory as well.
Floyd's Auto Sales's experienced staff is eager to share its knowledge and enthusiasm with you. We encourage you to browse our online inventory, schedule a test drive, or contact our knowledgeable experts. Whether you are from Stillwater, Saint Paul, Minneapolis, , or anywhere else in the MN region, Floyd's Auto Sales is there for you. We look forward to serving you! Floyd's Auto Sales is your Stillwater Used Cars lot in Stillwater and serving Saint Paul, Minneapolis. As a Stillwater Used Cars lot, we offer used cars for sale, used vehicles, usedcars, pre-owned cars to customers from Saint Paul, Minneapolis.
We hope that you find our website helpful to your needs. Although Floyd's Auto Sales of Stillwater in MN doesn't stay open 24 hours a day, our dealership website is always open all day, every day! On our website which serves Stillwater area customers, you can research our Used Cars, Used Cars, used cars for sale, used vehicles, usedcars, pre-owned cars. Search the extensive inventory of all the Floyd's Auto Sales Used Cars that we offer at great prices, request a vehicle price quote, view pictures and data about the Used Cars or learn about our Used Cars that we currently have. Give us a call at 651-429-6009.
Stillwater Used Cars | Saint Paul MN Used Cars | Minneapolis Used Cars

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Monthly Health E-News January 2012
January 2012
NCH publishes monthly newsletters covering several health topics that may be of interest to you. Please click on a newsletter below:
Breast Health News
This month's featured topic:
Drinking Raises Risk for Breast Conditions
Young women with a family history of breast cancer are at higher risk of developing other types of breast conditions if they also drink alcohol, a new study says.
Read More
Diabetes Health News
This month's featured topic:
Kidneys Benefit from Tight Control of Blood Sugar
People with type 1 diabetes who maintain good control of their blood sugar levels may be able to halve their risk for kidney complications.
Read More
For Your Child News
This month's featured topic:
Diagnosis of Autism Varies Widely Across U.S.
Researchers have found that health care providers at different autism centers are inconsistent in determining whether a child should be diagnosed with autistic disorder or a subtype, such as Asperger syndrome.
Read More
Heart Care News
This month's featured topic:
Healthy Habits May Help Heart and Block Cancer
Want to prevent both heart disease and cancer? Here's how: Don't smoke, maintain a healthy weight, and control blood pressure and cholesterol levels
Read More
Men's Health News
This month's featured topic:
Construction Workers at High Risk for Injury and Illness
Despite steps taken to reduce injuries on construction sites, a new report found that workers have a 75 percent chance of suffering a disabling injury over a 45-year career and a one-in-200 risk of being fatally injured on the job.
Read More
Mind & Body News
his month's featured topic:
Do Certain Blood Types Boost Stroke Risk?
In an intriguing study, researchers found that people with blood type AB had a 26 percent increased risk for stroke compared with those with blood type O.
Read More
Women's Health News
This month's featured topic:
'Broken Heart' Syndrome More Common in Women
Broken heart syndrome - a temporary heart condition brought on by extreme physical or emotional stress - is far more likely to occur in women than in men.
Read More
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The NCH Healthcare System is a not-for-profit, multi-facility healthcare system located in Naples, Florida, United States. The System is more than just two hospitals (referred to as the NCH Downtown Naples Hospital, and NCH North Naples Hospital) with a total of 715 beds. The NCH Healthcare System is an alliance of 650 physicians and medical facilities in dozens of locations throughout Collier County and southwest Florida. The services offered by the NCH Healthcare System are extensive. Inpatient services include: medical, surgical, cardiac, orthopedic, obstetric, pediatric, rehabilitative, psychiatric, oncology, emergency treatment, and diagnostics. Outpatient services include: rehabilitation, home care, walk-in centers, wound healing, and more. This year the system had 37,284 admissions, 87,100 emergency room visits, 3,033 births, 416 open heart surgeries, 11,282 surgical procedures, and 3,000 employee colleagues. NCH is a member of the Mayo Clinic Care Network.
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Narrow your search
Get root access for your Android device.
News, analysis and tips on the Google Android operating system, and devices and apps that use it.
With an ever-growing selection on Google Play, it can be near impossible to cut through all the
This nifty system connects your Android phone to your computer's desktop so you can answer phone calls and reply to text messages remotely.
Although its ability to use GPS to track your run is handy, its poor screen, uninspiring design and lack of a heart-rate monitor means the SmartWatch 3 doesn't impress over its more luxurious Android Wear competitors.
Our most popular How Tos published in 2014.
The tech giants finally relinquish their hold on the highly-coveted technology rights, possibly marking the end of a patent fight between Android phone manufacturers and competitors.
ZTE's latest flagship phone doesn't need dual cameras or fingerprint sensors -- it comes packing integrated voice control for a hands-free experience.
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CNET member Nate650 shares with us his thoughts on why BlackBerry is well-positioned to rebound.
Here are seven things we could see from Apple in the coming year, ranging from services to new, bigger iPads.
This clutter-busting Android app helps keep your email organized.
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The new 5.5-inch phone from Chinese smartphone maker Huawei packs an octa-core processor, a full-HD display and two 8-megapixel rear cameras.
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As far as free theft-deterrent and motion-notification systems go, Salient Eye has the lock on simplicity.
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Definitions for henbaneˈhɛnˌbeɪn
This page provides all possible meanings and translations of the word henbane
Random House Webster's College Dictionary
an Old World plant, Hyoscyamus niger, of the nightshade family, that has hairy foliage and possesses narcotic and poisonous properties.
Category: Plants
Origin of henbane:
Princeton's WordNet
henbane, black henbane, stinking nightshade, Hyoscyamus niger(noun)
poisonous fetid Old World herb having sticky hairy leaves and yellow-brown flowers; yields hyoscyamine and scopolamine
A poisonous plant, Hyoscyamus niger, used sometimes as a drug that causes at least hallucinations, dilated pupils, restlessness, and flushed skin.
Any other plant of the genus Hyoscyamus.
Origin: From hen + bane.
Webster Dictionary
a plant of the genus Hyoscyamus (H. niger). All parts of the plant are poisonous, and the leaves are used for the same purposes as belladonna. It is poisonous to domestic fowls; whence the name. Called also, stinking nightshade, from the fetid odor of the plant. See Hyoscyamus
Hyoscyamus niger
Hyoscyamus niger, also known as stinking nightshade or black henbane, is a plant of the family Solanaceae that originated in Eurasia, though it is now globally distributed.
Find a translation for the henbane definition in other languages:
Select another language:
Discuss these henbane definitions with the community:
Use the citation below to add this definition to your bibliography:
"henbane." Definitions.net. STANDS4 LLC, 2014. Web. 19 Dec. 2014. <http://www.definitions.net/definition/henbane>.


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Broad Comedy
Touring all over the U.S.and internationally for the last 15 years, these Broads get around. They have been seen at the following locations, causing audience members to complain that their cheeks hurt from laughing so much: A gazillion performances for fundraisers for Planned Parenthood and other women's health non-profit organizations... Performances at Caroline's Comedy Club on Broadway... Colleges across the nation... A two-month run at the Acme Comedy Theater in West Hollywood... A three-month run at the Stuart Street Playhouse in Boston... A nomination for the White House Project Emerging Artist Award... A month in Scotland with their Edinburgh Fringe Festival debut, where they were a "Top-Ten Sketch Comedy Pick" (FringeReview)... Winner of The Vancouver Fringe Festival... This troupe of Broads performs a high-energy, musical satire and sketch comedy show, tackling soccer moms, the right wing, abstinence-only education, homphobia, MILFs, various anatomical shenanigans, and things you should never discuss with your mother-in-law.
The lovechild of Co-Authors and Co-Directors Katie Goodman and Soren Kisiel, Broad Comedy has been a smash hit performing to sold-out audiences around the world. See the huge list of rave reviews here.
Their CD is available on itunes, and their music videos on youtube. (See also, the link above for Katie Goodman.)
- Home
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Not a square
A flat pack fruit presenter. The flexibility of the elements allow the corners of the square to curl up and create a bowl shape.
Who would have thought a square could be so curvy...?
Not a square is semi-transparent and almost looks like it's not there. As if your fruit is floating above your table, the bowl itself does not draw more attention then necessary.
Not a square is 100% recyclable. And, unlike other materials, maintaining its quality during the recycling process. To emphasize this the elements are covered with a subtle print of the universal recycle logo for the material PP, combining information and decoration.
photo's: Tim Stet
Price: € 39,00 *
* excluding shipping
* excluding shipping


text:
Friday, April 15 2011
Battlefield 3 'My Life' Trailer by Craig D at 14:16
Here's another Battlefield 3 trailer, this one is titled 'My Life' and is a bit of a montage of the three fault lines series trailers with very little new footage to be seen.
You can watch it in HD though if you like.
You can watch it in HD though if you like.
Tags: Battlefield 3
|Battlefield 3: Aftermath Launch Trailer
|Battlefield 3: Armored Kill Trailer
|Battlefield 3 Premium Launch Trailer
|Battlefield 3 Close Quarters 'Donya Fortress' Trailer
|Battlefield 3 'Close Quarters' Screenshots
|Battlefield 3 'Ziba Tower' Trailer
|50% Off Battlefield 3 on Origin
|Battlefield 3 'Back to Karkand' Launch Trailer
|Battlefield 3 'Wake Island' Gameplay Trailer
Why not register and have your say?
Dec 15 22:25 by Maz
BF2 and Life since
BF2 and Life since
Nov 19 07:26 by bibi123
Duke Nudem
Duke Nudem
Feb 26 11:23 by johnenla
pc for sale
pc for sale
Feb 26 11:16 by johnenla
Merry Christmas Everyone!!
Merry Christmas Everyone!!


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Teen Crying After Intruder Roughly Fucked Her And Cummed On Her Face
Unfortunately, crying will not make her feel any better.
Slutty ass needs rough hardcore banging
Two Guys Roughly Fucked Busty Housewife
Busty italian milf gets dp
Busty Asian Girl Fucked in Public Train
She should not use public train so late.
Innocent Sexy Girl Roughly Anal Fucked
After this anal punishment she could not walk as before
Dirty Black Guys Roughly Banged Sweet Teen Girl
Gangsta Bang - full movie
Asian Teen Girl Attacked In Public Bus
Using bus in Japan may be the wrong idea
Hot Ass Asian Babe Will Never Fuck Stranger Again
This rough guy fucked her for long remembering
Drunk Asian Business Woman Gave Blowjob in Public Train
She is totally drunk and train toilet could be dangerous place, especially in such situation
Sexy Teen Roughly Fucked By Two Guys In Public Toilet
She definitely, after this bad experience will never again use public toilets
Poor Girl Attacked in the Wood and Roughly Fucked
She should know that walk alone through the woods can be dangerous
Skinny Slutty Teen Tied Up And Fucked Hard
Well hung dude has no mercy for girls mouth and pussy
Sexy Girl Having Rough Sex With Enormous Guy
I guess her pussy will never be so tight after this!
Tight Ass Teen Roughly Fucked In The Classroom
She will never teasing her experienced dirty teacher
Dubm Tourist Girl Tricked Into Having Sex In Public Park
Who can blame them, dude was horny and girl was so naive.
Bored Booty Chick does Something she Regrets
Boredom can make people do strange things
Angry Milf Punished Her Husband With Rough Face Sitting
He will never cheat her again after this dirty fucking
Horny Guy Roughly Banged Mature Asian Ass
Only rough sex can satisfy this mature slut
Perv Boss Used His Position To Blackmail Young Booty Secretary
Her only mistake was that she came to work in such a short skirt.
Sexy Ass Slut Will Never Tease Black Guy Again
She learned good lesson after this rough fucking
Naughty Boy Roughly Fucked Sexy Ass Neighbor Mom
Hot milf shouldnt trust this dirty young man
Teen Chose Bad Shortcuts In The Woods
Crazy Guy Jacks Off While Girl Talking On The Phone
Warning, Hot Ass Babe Grabbed and Fucked Very Rough
This poor girl gets fucked beyond repair
Cute Asian Teen Groped and Fucked in Public Subway
Who would say that something like this can happen in public subway. Frightened girls did not know what hit them
New Milf Neighbor Walks Around Without Panties
Unfortunately for booty MILF, this wasnt neighborhood which she expected when she decided to buy house...
Teen Asian Girl Roughly Fucked In Public Library
Creepy maniac knew that girl couldn't scream in full library and used this opportunity to fuck teen girl.
Booty Mom Will locked Door Next Time While Sleeping
Naughty boys made dirty fucking party with wasted friends mom
Walking Around Without Panties Isnt Smart Idea
Girl learn to stay in her room when she is alone with stranger...
Public Bus Is not Safe Anymore
Girl should never take a drive with unknown guy
Blonde Teen Forgot to Lock The Door
She payed with pussy for making such a big mistake


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Dr. Michael Treece's Ratings
Dr. Treece is very knowledgeable and well informed, patient and kind with kids and parents alike. He is very approachable, easy to reach on the phone, and encourages questions. I couldn't ask for more in a pediatrician. He is flexible and respectful of our nontraditional parenting choices, and never undermines our confidence as parents. He is strongly pro-breastfeeding but again is respectful of individual parents' choices and does not push his agenda in a negative way at all. I cannot recommend him highly enough.
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text:
If you are looking for a LIGHT duvet, and want the option to add a nice blanket- this is the perfect all season solution. Alone it may not be enough, but in a duvet cover or with sheets (and possibly a nice cotton blanket) it is fine for our climate. Decent construction, nice balance of filling and well stitched- this came in way under most feather/down duvets and keeps you as warm if not warmer than a traditional down duvet. I have told others to get this if they are looking for a solid layering piece.
I comparison-shopped and found that Overstock had the best deal for an all-season comforter. A couple of things that affected my decision: I live in FL, so even in "winter," it's not really wintery weather, which means I didn't need a heavy comforter. I knew I'd be using a duvet cover, so I didn't splurge on a high-thread count for the comforter itself. With those things in mind, this works great for me.
heavy duty on those cold nights, feathers start to fall out after your first wash, you have to put a duvet on it or else be prepared to sweap feathers from your floor everyday.
Could have been just a bit thicker, just to give the appearance of more comfy. However, it is just what we needed. My husband gets too hot, and I get too cold. This works well for both of us.
I was expecting a lightweight microfiber comforter, and this one WAS lightweight. However this comforter had a strong chemical odor that was not noticable right away; the odor intensified the longer you had it covering you. The chemical smell was suffocating and unbearable after an hour of lying under it. I held it up to the light, and could see a scattering of dark brown feathers (no down, which is white and soft). I don't know what was in this thing, but I returned it immediately. I think it is dangerous to your health!
his item was returned since the filling would not fill out the pockets & was not good cover
Not sure why but my comforter has yet to completely expand. After fluffing every other day or so some of the boxes are filled and the others are completely flat. It looks awful and not presentable. The instructions stated it would take 48 hours to do so, but it has been almost a month. It is noisy as I'd read in other reviews prior to purchasing. Guess I should've followed my first instinct and not purchased it at all.
I have purchased 4 goose down pillows and a goose down king sized mattress topper from overstock and absolutely loved the products. Wish this was the case with this purchase. It started out arriving like a pancake so I laid it out for 48 hours on a king sized bed flat fluffing it several times a day. Noticing a steady worsening odor coming from the comforter??? Began to stink up the room so I placed it in my front loader on special setting of down pillow setting where I was hoping the smell would be eliminated. I was wrong. The smell got so severe I almost threw it away, it smelled like a dead body!! I'm in the medical field bad smells don't usually both me but this one almost took me down and out! I have no clue what to do with this nasty smelling comforter! I'm pretty sure its going back to overstock!!!
Love this comforter! It is very warm and was a great price. I use it every night inside of a duvet cover and am very satisfied with the product.
very pleased, fluffed up well and is a good weight for us.
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text: Hola Amigos! I just returned from a transformative week in gorgeous Uvita, Costa Rica where I was living la pura vida and working at an event called Envision Festival. As you may recall from my last blog post, I was a little apprehensive about going on vacation and sticking to the plan. I left on day …Read more »


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Congress is finally give nursing homes the attention
- 0Mar 25, '09 by rabbitgirrl"Nursing Homes, like deteriorating public schools, crumbling bridges and other pieces of our societys essential infrastructure have been neglected for a long time."
- 1Mar 26, '09 by Ginger's PersonI hope this new found interest in nursing homes will result in more federal funding funding for nursing education! While penalties for under performing and abusive institutions are important, you can't punish the nursing home system into excellence. We need to train up better leaders than the MBA's who are in charge now
People are terrified of getting bad medical care, so we spend billions to train MD's. It looks like people are finally learning how frightened they should be about bad or not enough skilled nursing care, so maybe they'll start thinking about that when the write the next medicare education budget.
- 3Mar 26, '09 by rabbitgirrlI think you have made a great point, but here is the really scary part of the article-
"Roughly two-thirds of U.S. nursing homes are now owned by for-profit firms, and many worry that the top priority for these new private-equity owners would be profits, rather than providing the staffing and resources necessary to ensure top quality care for our loved ones, Pawelski explains. Frequently, they use complex corporate structures, separating the nursing home real estate from the operating companies and putting multiple layers of limited liability partnerships between themselves and the day-to-day operations of the nursing home.
Ownership structures with multiple stakeholders have been used by other private-equity firms to minimize liabilities and shield them from regulator inquiries such as when cutting staff is made to improve profit margins. This is how they avoid taking responsibilityeven while when taking control of the nursing homes.
Private equity is buying up this industry and then hiding the assets, he adds and when residents die from lack of proper care, there is little the courts or regulators can do. Meanwhile the private investors skim off the profits to line their pockets -- or to plow the money into separate ventures that have nothing to do with nursing home care."
- 1Mar 26, '09 by Ginger's PersonWhoa I just skimmed past that part. That is repulsive.
- 4Mar 27, '09 by BradleyRN"the Bush administration wanted to deregulate nursing homes"
Did the bush administration ever do one uncorrupted thing? Every time his name comes up, it seems to be linked to evil. How long will that criminal walk free?
- 3Mar 27, '09 by rabbitgirrlQuote from BradleyRN"the Bush administration wanted to deregulate nursing homes"
Did the bush administration ever do one uncorrupted thing? Every time his name comes up, it seems to be linked to evil. How long will that criminal walk free?
A-men to that!
- 1Mar 27, '09 by LexnursingstudentAnother nursing just went all LPN staff. WOOOOOOO!!!!! wait a minute, now what is going on here.
Why no more RN's? does anybody know??
I am going to ask the ANA about this?:typing
- 4Mar 28, '09 by WYDiceDancerQuote from LexnursingstudentAs an RN, there is no way I would work in a nursing home. I worked in several as an LPN and the things I saw other things LPN's doing was wild (IV push Lasix, phlebotomy on feet, the list goes on and on). When you work in a nursing home as an RN, you are usually the ONLY RN in the building, therefore are responsible for the actions of the LPN's and CNA's working at that time. How are you, as the only RN in the building, supposed to "supervise" the other staff in a 100+ bed facility when you have your own assignment of 25-30 residents? I WILL NOT put my license on the line like that. Acuity of the residents is so different (much higher) than when the "regulations" were put in place. Add that to that the fact that the management does not want to staff even minimally, it's a wonder that ANY RN will work LTC. The whole system needs to be re-evaluated for what's needed today, not 50 years ago.Another nursing just went all LPN staff. WOOOOOOO!!!!! wait a minute, now what is going on here.
Why no more RN's? does anybody know??
I am going to ask the ANA about this?:typing
- 3Mar 28, '09 by gdpawelTreasury Secretary Timothy Geithner said that "new rules of the game" are necessary to restore confidence in the financial system after credit markets seized up and stocks fell the most since the Great Depression. He proposed requiring private-equity firms to register with the U.S. Securities and Exchange Commission and to disclose information about their holdings.
After opposing increased federal oversight for years, David Rubenstein, co-founder of private-equity firm Carlyle Group, admitted that they are not going to be able to stand in the way of including them in an overhaul of U.S. financial regulation.
The government would have the power to peer into the inner workings of companies like the Carlyle Group that currently escape most federal supervision. Private-equity funds operate almost entirely outside the regulation of either the Securities and Exchange Commission or the Federal Reserve.
Regulation of Carlyle's Manor Care nursing homes is good and necessary, particularly since the company accepts taxpayer funds for the majority of the residents of their facilities. The private-equity for-profit operators of these nursing homes need to hire the best caregivers available and pay them a living wage. They need to provide clean, well-kept facilities that meet all state and federal standards, with good food and good access to healthcare services.
More and more, nursing homes are letting LPNs in charge of floors. The state nursing practice act dictates what a RN and LPN can do. Now I'm not saying that I have anything against LPNs - actually some of them are better nurses than some RNs, it's just that they are not formally trained to do the job of a RN yet they are placed in that role in nursing homes because they are much cheaper to hire.
As far as I remember, LPNs do not receive training in nursing school on how to be a charge nurse. A RN has about 3 months of training in leadership on a floor (some as many as 60 patients). Therefore, in my opinion, the nursing homes are being run by untrained staff, if you will. The RNs hired in the nursing home my mother lived in made sure the "paperwork" was perfect. I truly believe care in nursing homes would improve greatly if all charge nurses were RNs, or LPNs had the formal training in school for that position.
- 0Mar 28, '09 by LexnursingstudentIt depends on how many residents the facility holds--- ya know????? Me and a finance specialist were talking yesterday, and we discussing layoffs in nursing, it is inevitable, like any other business, like police departments. Here it is inevitable that 100, yes, there will be a layoff of 100 police officers and firefighters July 2009. I just read the minutes of our cities town meeting. And why would that be? To put more money in the city's big wig's pockets.
Hey congress do not care about nursing more than anything else. They care right now about the banking business, where the REAL money situaition is. Don't look for anything special for nursing, and this goes for other busineses too, becuase this mess about the banking and CEO incentives has to be straightened out, and that is going to take another year for all these hearings. So, while these hearings are going on businesses like hospitals, retailers, school nurses, and big resturant chains are going to go bust! There will even be some of the most bigges retail businesses CLOSE. Right now one of the most biggest retailers is not a 24 hours business, some stores close early. People just simply do not have the money to but stuff. Personally, I think that Wal Mart is one of the most expensive places to shop. I have seen Wal Mart's prices go up, and up, and up. The other day, I thought that their produce, KIWI was too expensive, and it was all mushy. No, my post is not about Wal Mart. but......my point is, people cannot afford to go to the hospital either, and so there will be no patients to take care of. There has to be patients (the business part of a hospital) for nurses to have a job.
Get a VISA and travel to another country, like Scotland, Israel, CANADA (pay nurses good money) Alaska, to make good money as a nurse. Here in the US, we are seeing RN wages fall , 18.00 dollars an hour. That is sad sad sad!!! My little neice works in a nursing home, when she works extra hours a week-night shift with diferential pay, she makes more than the RN's. SAD SAD SAD
Do not believe congress at this time about anything. That is politics!!!!!!!


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Just over half of the population of Chad is Muslim, with Christians comprising a sizeable minority of around a third. Islam is dominant in the north, while most southerners practise Christianity or indigenous religions. Over the last three decades, Islam has extended its influence into the south; increasing numbers of Muslims are found there, with mosques and Muslim schools in predominantly Christian areas to serve them.
Chad is made up of many ethnic groups, and there is a constant threat of conflict between rebel groups and the government.
Despite being only a slight majority in Chad, Muslims are dominant politically and economically, leaving Christians marginalised. In a country where 80% of people live below the poverty line and where droughts can be severe, the Christian community is in need of practical help.
Foreign Islamic groups and nations are backing a number of Islamist movements in Chad, and membership of these more extreme Islamic groups is growing. The Church needs support and training to reach out to Muslim communities and to withstand Islamisation.
The country is a secular state, and the constitution and other laws protect religious freedom. Chad is one of the very few Muslim-majority countries where Christian workers are welcome and evangelism is not restricted. However, there are occasional tensions between Christians and Muslims.
Related Articles
- Editorial: Rising tide of Islamism in North Africa threatens Christians - Thursday 02 May 2013
- Barnabas Persecution Update 02 May 2013 - Thursday 02 May 2013
- Prayer Focus 11/12 - Thursday 01 November 2012
- Help us bring aid to forgotten Christian flood victims in Chad and Cameroon - Thursday 25 October 2012
- Barnabas Persecution Update 25 October 2012 - Thursday 25 October 2012
- Barnabas helps Christians hit by heavy flooding in Chad and Cameroon - Thursday 18 October 2012
- Barnabas Persecution Update 18 October 2012 - Thursday 18 October 2012
- Reaching the unreached through Christian workers supported by Barnabas - Thursday 18 August 2011
- Praying for the Persecuted Church in Lent - Evangelists - Sunday 28 March 2010
- Chad - Radio Station Generator 08-1173 - Thursday 01 January 1970
- Barnabas Persecution Update 02 May 2013 - Thursday 02 May 2013


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Photo #: 19-LC-38-L-2
USS Marcus (DD-321)
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Offer: Now Accepting Applications: 2011 Bologna, Italy Symposium on Conflict Prevention, Resolution, and Reconciliation
In cooperation with Johns Hopkins University Paul H. Nitze School of Advanced International Studies (SAIS), the 2011 Bologna Symposium will bring together the globe's brightest young minds from top graduate institutions, international organizations, grassroots peace movements, and the armed services. Over a four-week period, participants will undergo intensive training by the field's premier political leaders, academic experts, practitioners, and advocates in the practical skills necessary to foster peace and security in their communities and the world. In addition, participants may apply to earn graduate-level course credit from SAIS, one of the world's top graduate schools for international affairs.
The course work includes modules on conflict prevention, conflict management and resolution, and post-conflict reconciliation and reconstruction. Participants graduate from the program with the knowledge to effectively confront violent conflict – be it ethnic, social, political, religious, or economic – through learned mediation, negotiation, facilitation, social entrepreneurship, leadership, and societal transformation techniques and a clearer understanding of the dynamics of contemporary conflicts.
The Bologna, Italy Symposium on Conflict Prevention, Resolution, and Reconciliation will take place from June 26 – July 22, 2011.
The IPSI Bologna Symposium strives to attract a diverse and accomplished student body from across the globe, especially peace and security leaders from conflict and post-conflict countries. A balanced and effective student body will draw from a broad spectrum of regions, religions, and ethnicities. IPSI will accept up to 80 young professionals, graduate students, and accomplished rising seniors, based on one or more of the following criteria:
* Stellar academic and/or professional achievement
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To be considered for matriculation, you will need to provide the following materials via our online application form:
* Résumé or Curriculum Vitae
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o WHY you would like to attend the Bologna Symposium & WHAT you intend to do with the training received
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* $25.00 application fee (waived for full scholarship applicants)
Scholarship applicants are responsible for submitting an additional short essay on "why you are uniquely suited to utilize IPSI's trainings to foster peace & security in your country/region."
IPSI will accept applications in three rounds from November 18, 2010 – April 25, 2011. Early Decision Deadline is January 31st!
LIMITED SCHOLARSHIPS: IPSI will carefully select a number of participants from conflict and post-conflict countries to receive partial-to-full scholarships for the Bologna Symposium. To achieve a diverse and balanced group, IPSI will consult with embassies, universities, international organizations, NGOs, and other contacts on the ground to seek out participants that have the greatest ability to influence policy and/or impact the grassroots. IPSI will place special emphasis on recruiting participants that work for peace, understanding, and reconciliation on opposing sides of any given conflict.


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Hello Dr. Lam
I recently relocated to Dallas from Washington DC, and while I was there I visited a couple of Dermatologists/Plastic Surgeons to address two issues: puffy bags around my eyes and a scar on the top part of my ear. I inquired about eyelid surgery for my eyes, and was told I did not qualify bc it wasn't severe. However, I am constantly told that I look like I am tired (when I am not) or that I am sad (when I am not). I was wondering if there is something (alternatively) you could recommend for my situations (i.e. there is not pronounced puffiness under my eyelids, but around my eyelids) if that makes sense. As for my ear, the scar gives it a pointy look, which has always made me self-conscious. I am an African American male who spends a lot of time interacting with others in my career, and would like to have these issues successfully addressed. I would really love to have insight from you or maybe even schedule a visit to your office.
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The Tampa Port Authority has announced that Geneva-based Mediterranean Shipping Co. will start offering its global container service at the Port of Tampa.
The service will be provided in partnership with Zim Integrated Shipping Services using five vessels, each with a capacity of 3,000 20-foot-equivalent units, with three ships provided by MSC and two provided by Zim. The service will include direct calls at Caucedo, Dominican Republic; Kingston, Jamaica; Veracruz, Mexico; and Altamira, Mexico.
MSC will open up new destinations and options for exporters and importers via the Port of Tampa, Paul Anderson, the port's director and CEO, said in a written statement.


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Results tagged "Al Qaeda East Africa"
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Shabaab suicide assault team attacks Somali presidential compoundShabaab fighters dressed in military uniforms attacked a mosque inside the presidential palace. Two government officials are reported to be among those killed.
US justifies Somalia raid under AUMF, which Obama seeks to repealThe US Navy SEALs raid that targeted a Shabaab leader known as Ikrima was justified under the 2001 Authorization to Use Military Force. President Obama has called for the repeal of the AUMF, and support to do so is gaining in Congress.
Shabaab claims it 'repelled' raid by Western special operations forcesShabaab claimed that its fighters stopped a Western-led nighttime raid from the sea in the costal town of Barawe. The US special operations forces killed a top al Qaeda and Shabaab leader in Barawe four years ago.
Shabaab plot to attack London planned to be 'similar to ... Mumbai'A document found after Somali troops killed Fazul Abdullah Mohammed, al Qaeda's former leader in East Africa and a senior Shabaab commander, details a plot to conduct multiple Mumbai-like attacks that target civilians in London.
UN warned of Shabaab ally's 'new and more complex operations' in KenyaA report published by a UN Monitoring Group in July warned that Al Hijra, Shabaab's affiliate in Kenya, was planning more complicated attacks utilizing fighters who had returned from Somalia. The report also revealed that the US has been funding the "Al-Shabaab/East Africa Al-Qaida Disruption Initiative," which has targeted Al Hijra's leaders.
Shabaab emir praises group's assault on Kenya mallSheikh Mukhtar Abu Zubayr threatened further attacks in Kenya if its military is not withdrawn from southern Somalia. He also noted that the assault on the Westgate Mall was "just 10 days after the anniversary date of the blessed 911 operations."
Kenyan forces end Shabaab's siege at mallPresident Kenyatta said that five Shabaab fighters were killed and 11 more were captured. Sixty-two civilians and six Kenyan troops were killed during the attack on the Westgate Mall.
Shabaab executes French hostage Denis Allex"With the rescue attempt, France has voluntarily signed Allex's death warrant," the terror group said in an official statement. Shabaab later announced he was executed. The French intelligence agent has been held by Shabaab since July 2009.
Shabaab releases photos of French commando captured in failed rescue missionShabaab displayed the body and equipment of a French commando who was wounded and captured late last week following a failed hostage rescue in Somalia, and later died. The terror group also said the "fate" of hostage Denis Allex will be announced soon.
Shabaab kills, captures French soldiers during failed rescue mission in SomaliaFrench commandos from the General Directorate for External Security attempted to rescue Denis Allex, one of their operatives captured in 2009. The French said they believe Allex was killed in the raid; Shabaab denied the claim.
Shabaab rebukes American commander Omar HammamiAl Qaeda's affiliate in Somalia has broken its nearly year-long silence on the American jihadist who has claimed that deep divisions exist between foreign fighters and local jihadists.
Kenyan Muslims riot after murder of Shabaab-linked clericSheikh Aboud Rogo Mohammed was shot and killed as he was driving in Mombasa. The US added Rogo to the list of Specially Designated Global Terrorists on July 5 for his direct support for Shabaab.
7 Shabaab leaders added to Rewards for Justice most wanted listShabaab emir Sheikh Mukhtar Abu Zubayr's reward of $7 million puts him at number six on the Rewards for Justice list of wanted terrorists.
Shabaab suicide bomber kills 3 members of Somali parliamentThe al Qaeda affiliate has executed 10 suicide attacks in Somalia already this year.
Shabaab claims bombing at Mogadishu theaterTwo top sports official were among 10 people killed. Somalia's defense minister claimed the attack was carried out by a female suicide bomber, but Shabaab denied the claim.
Shabaab denies top leader granted interviewShabaab said that a purported interview with Sheikh Abu Mansur Robow that was published two days ago by Somalia Report is "entirely fictitious."
Omar Hammami 'not endangered by the Mujahideen,' Shabaab claims"HSM is surprised by the video of Abu Mansoor #AlAmriki that surfaced on the internet," Shabaab said on its Twitter page.
Shabaab suicide bomber strikes at presidential palace in MogadishuShabaab continues to be able to penetrate high-security areas in the Somali capital. At least four Somalis were killed in the attack.
Somali Islamist group formally declares allegiance to Shabaab, al QaedaSheikh Mohammed Said Atom's forces in Puntland, which have operated under the aegis of Shabaab for years, have officially declared allegiance to the terror group.
Moroccan jihadist killed in Somalia airstrikeAbu Ibrahim was one of three foreign jihadists killed in today's strike south of Mogadishu. The attack was likely carried out by the US.
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Wednesday, August 15, 2012
Epic Food Company, Wilmington, NC
The picture above is salmon on a flatbread with cilantro, grilled scallions and a few other things. The best way to describe it is simply amazing and say that you really have to go to Epic Foods in Wilmington.
The service was warm and friendly, and helpful. The ambiance is bright and inviting with a surfer theme. The prices are downright reasonable. The food is fresh and delicious. Overall, a winner that I will be going to often.
Posted by Chris Forman at 8:44 PM
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Treatment of endothelial dysfunction in diabetic patients
United States Patent: 7,956,035
Issued: June 7, 2011
Inventors: Stroes; Erik S.
G. (Amsterdam, NL)
Assignee: CSL Limited
(Parkville, Victoria, AU)
Appl. No.: 11/712,404
Filed: March 1, 2007
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A method for the treatment of endothelial
dysfunction in a diabetic patient, including both diabetes induced
macrovascular disorders and diabetes induced microvascular disorders,
comprises administration, preferably parenteral administration, to the
patient of an effective amount of high density lipoprotein (HDL).
Description of the
This invention relates to a method for the treatment of endothelial
dysfunction in diabetic patients. In particular, this invention relates to
a method for improving endothelial function in treatment of disorders
which are related to endothelial dysfunction, both macrovascular and
microvascular, in diabetic patients.
In the chronic disease diabetes mellitus (diabetes), the body loses the
ability to properly produce or respond to the hormone insulin so that
cells of the peripheral tissues fail to actively take up glucose from the
blood for use or storage. In the diabetic individual, the level of glucose
in the peripheral blood can become elevated (hyperglycaemia) and typically
remains so unless some form of intervention is employed (e.g.,
administration of exogenous insulin) to return glucose in the blood to
normal levels. Left unchecked, the hyperglycaemia of diabetic individuals
can result in shock, organ degeneration or failure (e.g., kidney failure,
blindness, nerve disease, cardiovascular disease), tissue necrosis (e.g.,
requiring foot amputation), and even death.
Two major forms of diabetes are type 1 and type 2 diabetes. Type 1
diabetes, which was previously known as insulin-dependent diabetes
mellitus (IDDM) or juvenile onset diabetes, is an autoimmune disease in
which the body destroys the insulin-producing .beta. cells (islet cells)
of the pancreas resulting in an absolute requirement for daily
administration of exogenous insulin to maintain normal blood glucose
levels. Type 1 diabetes usually is diagnosed in children and young adults,
but can occur at any age. Type 1 diabetes accounts for 5-10% of diagnosed
cases of diabetes.
By far the more prevalent form of diabetes is type 2 diabetes, which was
previously known as non-insulin-dependent diabetes mellitus (NIDDM). Type
2 diabetes was also previously known as adult-onset diabetes, however,
this form of diabetes is becoming increasingly prevalent in the growing
population of overweight and clinically obese children and young adults.
Type 2 diabetes accounts for approximately 90-95% of all diagnosed cases
of diabetes. Type 2 diabetes typically begins with insulin resistance, a
disorder in which the body's cells do not respond to insulin properly,
followed by a gradual loss on part of the pancreas to produce and secrete
insulin. Type 2 diabetes is associated with a variety of factors including
older age, obesity, family history of diabetes, history of gestational
diabetes, impaired glucose metabolism, physical inactivity, and various
races or ethnicities. Individuals with type 2 diabetes must attempt to
control their blood glucose level with careful diet, exercise and weight
reduction, and additional medications.
Major factors contributing to the pro-atherogenic state in diabetes,
particularly type 2 diabetes mellitus (DM2), include dyslipidemia,
hyperglycemia, hypertension, visceral obesity and insulin resistance
(1,2). Observational studies have clearly demonstrated the importance of
diabetic dyslipidemia in contributing to atherogenesis in diabetes,
illustrated by the fact that the correlation between low density
lipoproteins (LDL) as well as high density lipoproteins (HDL) versus
cardiovascular events outweighs that of fasting plasma glucose (3). Statin
intervention studies have revealed a clear benefit of statin treatment on
reduction of cardiovascular events in DM2 (4, 5); however, in spite of
this impressive achievement, the majority of DM2 patients will still
suffer from cardiovascular events even when using statins (6).
During the last two decades, endothelial dysfunction has emerged as one of
the earliest stages of atherogenesis. Endothelial dysfunction, which is a
hallmark in all diabetic patients (ie both type 1 and 2) has been shown to
have predictive value for future cardiovascular events (7-9). In line with
the multifactorial pathogenesis of diabetes-induced vascular disease (10,
11), numerous therapeutic interventions have been evaluated for their
potential to improve endothelial function in DM2 patients (9, 12).
Surprisingly, whereas endothelial function could be fully restored by
statin therapy in dyslipidemic patients (13), several studies have
demonstrated that even intensive statin treatment cannot normalize
vascular dysfunction in DM2 (14, 15). The latter emphasizes possibilities
for additional therapeutic modalities in this high risk group.
High-density lipoproteins (HDLs) represent a broad group of mostly
spheroidal plasma lipoproteins, which exhibit considerable diversity in
their size, apolipoprotein (apo) and lipid composition. HDL particles fall
into the density range of 1.063-1.21 g/ml (16) and as they are smaller
than other lipoproteins, HDLs can penetrate between endothelial cells more
readily allowing relatively high concentrations to accumulate in tissue
fluids (17). The major apolipoprotein of almost all plasma HDLs is apo
A-I, which in association with phospholipids and cholesterol, encloses a
core of cholesteryl esters (16). Nascent (i.e. newly synthesised) HDLs
secreted by the liver and intestine contain no cholesteryl esters and are
discoidal in shape (16). The negative association of plasma HDL
concentration with coronary artery disease has been well documented in
epidemiological studies (18). Although experiments in animals have
demonstrated an anti-atherogenic activity of HDLs (19), it is not yet
known whether this protective effect is related to the role of the
lipoprotein in reverse cholesterol transport or to a different mechanism.
The mechanism/mechanisms via which HDLs provide these cardioprotective
actions are not clearly understood, but may include a role for HDLs in
reverse transport of cholesterol from peripheral tissues to the liver,
inhibition of the oxidation of low-density lipoproteins, or modulation of
vasodilatation and platelet activation mediated by changes in the
production of prostacyclin (20). HDLs can also activate endothelial nitric
oxide (NO) synthase subsequent to its interaction with scavenger
receptor-B1 (SR-B1).
In view of the emerging data on the NO promoting effects of HDL, compounds
with HDL-increasing capacity are of particular interest (21-24). Indeed,
in DM2 patients HDL is positively associated with endothelium-dependent
vasomotor responses (8). In work leading to the present invention, the
inventors have evaluated whether and to what extent HDL increase upon
infusion of exogenous reconstituted HDL (rHDL) would translate into an
improvement of vascular function. ApoA-I levels and endothelial function
were assessed both acutely (4 hours after infusion) as well as 7 days
after infusion of rHDL in DM2 and matched controls.
Bibliographic details of the publications referred to in this
specification are referenced at the end of the description. The reference
to any prior art document in the specification is not, and should not be
taken as, an acknowledgment or any form of suggestion that the document
forms part of the common general knowledge.
Throughout this specification and the claims which follow, unless the
context requires otherwise, the word "comprise", and or variations such as
"comprises" or "comprising", will be understood to imply the inclusion of
a stated integer or step or group of integers or steps but not the
exclusion of any other integer or step or group of integers or steps.
In one aspect, the present invention provides a method for the treatment
of endothelial dysfunction in a diabetic patient, which comprises
administration (preferably parenteral administration) to the patient of an
effective amount of high density lipoprotein (HDL).
In another aspect, the present invention provides the use of high density
lipoprotein (HDL) in the manufacture of a medicament for administration
(preferably parenteral administration) to a diabetic patient for the
treatment of endothelial dysfunction in the patient.
In yet another aspect, the present invention provides an agent for
administration (preferably parenteral administration) in the treatment of
endothelial dysfunction in a diabetic patient, which comprises high
density lipoprotein (HDL).
Patients with diabetes, particularly type 2 diabetes mellitus (DM2), are
characterized by a marked increase in cardiovascular risk. Systemic
endothelial dysfunction, a hallmark in DM2, predicts future risk for
cardiovascular events. In view of the relation between HDL and the NO
pathway, the present inventors have evaluated the effect of rHDL infusion
on endothelial function in DM2. Specifically, in 7 DM2 patients and 7
normolipidemic controls, endothelial function was assessed using venous
occlusion plethysmography. Forearm blood flow (FBF) responses to
intra-arterial infusion of the endothelium-dependent and independent
vasodilators serotonin (5HT) and sodium nitroprusside, respectively, and
the inhibitor of nitric oxide synthase NG-monomethyl-l-arginine (L-NMMA)
were measured, both before, 4 hours after and 1 week after infusion of
rHDL (80 mg/kg based on protein).
At baseline HDL was similar in DM2 versus controls (1.1.+-.0.2 vs.
1.2.+-.0.3 mmol/L, ns). 5HT-induced vasodilation (max 17.+-.10%) and L-NMMA
induced vasoconstriction (max -17.+-.15%) were reduced in DM2 versus
controls (5-HT 114.+-.22 and L-NMMA -48.+-.5%, both p<0.05). rHDL infusion
raised apoA-I levels (1.2.+-.0.2 to 2.8.+-.0.4 vs. 1.2.+-.0.2 to
2.7.+-.0.4 g/L, p<0.01) in DM2 and controls, respectively and restored FBF
responses to 5HT (86.+-.22%, p<0.05) and L-NMMA (-45.+-.9%, p<0.01) in
DM2. This effect persisted 7 days after infusion (5HT; 80.+-.25%, p<0.05
and L-NMMA -37.+-.7%, p<0.01 compared to baseline). rHDL infusion had no
effect in controls. Accordingly, this work demonstrates that acute HDL
increase improves endothelial function in DM2 and that the improvement
persists for at least 7 days in spite of return-to-baseline of HDL
In one aspect, the present invention provides a method for the treatment
of endothelial dysfunction in a diabetic patient, which comprises
administration to the patient of an effective amount of high density
lipoprotein (HDL).
Preferably, the administration is parenteral administration.
Reference herein to "treatment" is to be considered in its broadest
context. The term "treatment" does not necessarily imply that a subject is
treated until total recovery. Accordingly, treatment includes amelioration
of the symptoms of a particular condition or disorder as well as reducing
the severity of, or eliminating a particular condition or disorder.
As used herein, references to "treatment of endothelial dysfunction" are
to be considered as references to improvement of endothelial function in
treatment of disorders which are related to endothelial dysfunction. Such
disorders include both macrovascular disorders (relating to the large
blood vessels) such as transient ischaemic attack, stroke, angina,
myocardial infarction, cardiac failure, and peripheral vascular disease,
as well as microvascular disorders (relating to the small blood vessels)
such as diabetic retinopathy (non-proliferative, proliferative, macular
oedema), microalbuminuria, macroalbuminuria, end stage renal disease,
erectile dysfunction, autonomic neuropathy, peripheral neuropathy,
osteomyelitis and lower limb ischaemia.
References herein to a "diabetic" patient are to be understood as a
reference to a patient suffering from either type 1 diabetes (DM1) or type
2 diabetes (DM2).
In accordance with the present invention, HDL is administered to a
diabetic patient. The term "HDL" as used herein relates to all forms of
high density lipoproteins and includes mature HDL, nascent HDL or
reconstituted HDL (rHDL) or any mixture thereof, as well as rHDL produced
from recombinant apolipoprotein or an analogue thereof with functional
relationship to nascent or reconstituted HDL. Such analogues include
functional peptides derived from the apolipoprotein (Apo) structure such
as those described in International Patent Publications Nos. WO 99/16459
and WO 99/16408, the contents of which are incorporated herein by
The high density lipoproteins comprise a protein component, and lipid. The
proteins are preferably apolipoproteins, e.g. human apolipoproteins such
as apolipoprotein A-I (apoA-I), apolipoprotein A-II (apoA-II) or
apolipoprotein A-IV (apoA-IV) or recombinant apolipoproteins, or
functionally homologous peptides with similar properties. Suitable lipids
are phospholipids, preferably phosphatidyl choline, optionally mixed with
other lipids (cholesterol, cholesterol esters, triglycerides,
sphingolipids, or other lipids). The lipids may be synthetic lipids,
naturally occurring lipids or combinations thereof.
Preferably, the HDL is reconstituted HDL.
Production of reconstituted HDL is described, by way of example, in U.S.
Pat. No. 5,652,339 and by Matz and Jonas (25) and Lerch et al. (26).
Production of rHDL with recombinant apolipoproteins is described, by way
of example, in European Patent No. EP 469017 (in yeast), U.S. Pat. No.
6,559,284 (in E. coli), and International Patent Publications Nos. WO
87/02062 (in E. coli, yeast and Cho cells) and WO 88/03166 (in E. coli).
The contents of each of these documents are incorporated herein by
The HDL is administered in an effective amount. An "effective amount"
means an amount necessary at least partly to attain the desired response,
or to delay the onset or inhibit progression or halt altogether, the onset
or progression of the particular condition or disorder being treated. The
amount varies depending upon the health and physical condition of the
individual to be treated, the racial background of the individual to be
treated, the degree of protection desired, the formulation of the
composition, the assessment of the medical situation, and other relevant
factors. It is expected that the amount will fall in a relatively broad
range that can be determined through routine trials.
Preferred HDL dosage ranges are from 0.1-200 mg, more preferably 10-80 mg,
HDL (weight based on apolipoprotein) per kg body weight per treatment. For
example, the dosage of HDL which is administered may be about 0.2-100 mg
HDL per kg body weight (weight based on apolipoprotein) given as an
intravenous injection and/or as an infusion for a clinically necessary
period of time, e.g. for a period ranging from a few minutes to several
hours, e.g. up to 24 hours. If necessary, the HDL administration may be
repeated one or several times. The actual amount administered will be
determined both by the nature of the condition or disorder which is being
treated and by the rate at which the HDL is being administered.
Preferably, the patient is a human, however the present invention extends
to treatment and/or prophylaxis of other mammalian patients including
primates, livestock animals (e.g. sheep, pigs, cattle, horses, donkeys),
laboratory test animals (e.g. mice, rabbits, rats, guinea pigs), companion
animals (e.g. dogs, cats) and captive wild animals.
In accordance with the present invention, the HDL is preferably
administered to a patient by a parenteral route of administration.
Parenteral administration includes any route of administration that is not
through the alimentary canal (that is, not enteral), including
administration by injection, infusion and the like. Administration by
injection includes, by way of example, into a vein (intravenous), an
artery (intraarterial), a muscle (intramuscular) and under the skin
(subcutaneous). The HDL may also be administered in a depot or slow
release formulation, for example, subcutaneously, intradermally or
intramuscularly, in a dosage which is sufficient to obtain the desired
pharmacological effect.
Compositions suitable for parenteral administration conveniently comprise
a sterile aqueous preparation of the active component which is preferably
isotonic with the blood of the recipient. This aqueous preparation may be
formulated according to known methods using suitable dispersing or wetting
agents and suspending agents. The sterile injectable preparation may also
be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable
diluent or solvent, for example as a solution in a polyethylene glycol and
lactic acid. Among the acceptable vehicles and solvents that may be
employed are water, Ringer's solution, suitable carbohydrates (e.g.
sucrose, maltose, trehalose, glucose) and isotonic sodium chloride
solution. In addition, sterile, fixed oils are conveniently employed as a
solvent or suspending medium. For this purpose, any bland fixed oil may be
employed including synthetic mono- or di-glycerides. In addition, fatty
acids such as oleic acid find use in the preparation of injectables.
The formulation of such therapeutic compositions is well known to persons
skilled in this field. Suitable pharmaceutically acceptable carriers
and/or diluents include any and all conventional solvents, dispersion
media, fillers, solid carriers, aqueous solutions, coatings, antibacterial
and antifungal agents, isotonic and absorption delaying agents, and the
like. The use of such media and agents for pharmaceutically active
substances is well known in the art, and it is described, by way of
example, in Remington's Pharmaceutical Sciences, 18th Edition, Mack
Publishing Company, Pennsylvania, USA. Except insofar as any conventional
media or agent is incompatible with the active ingredient, use thereof in
the pharmaceutical compositions of the present invention is contemplated.
Supplementary active ingredients can also be incorporated into the
Other delivery systems can include sustained release delivery systems.
Preferred sustained release delivery systems are those which can provide
for release of the active component of the invention in sustained release
pellets or capsules. Many types of sustained release delivery systems are
available. These include, but are not limited to: (a) erosional systems in
which the active component is contained within a matrix, and (b)
diffusional systems in which the active component permeates at a
controlled rate through a polymer.
The present invention also provides the use of high density lipoprotein (HDL)
in the manufacture of a medicament for administration, preferably
parenteral administration, to a diabetic patient for the treatment of
endothelial dysfunction in the patient.
In yet another aspect, the invention provides an agent for administration,
preferably parenteral administration, in the treatment of endothelial
dysfunction in a diabetic patient, which comprises high density
lipoprotein (HDL).
Claim 1 of 11 Claims
1. A method for the treatment of
endothelial dysfunction in a Type 2 diabetic patient, which comprises
administering to a Type 2 diabetic patient suffering from endothelial
dysfunction associated with a diabetes induced microvascular disorder
selected from the group consisting of diabetic retinopathy (non-proliferative,
proliferative, macular oedema), microalbuminuria, macroalbuminuria, end
stage renal disease, erectile dysfunction, autonomic neuropathy,
peripheral neuropathy, osteomyelitis and lower limb ischaemia, an amount
of high density lipoprotein (HDL) effective to treat said endothelial
dysfunction and improve endothelial function.
If you want to learn more
about this patent, please go directly to the U.S.
Patent and Trademark Office Web site to access the full


text:
Allison Janney
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Steve Jobs
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Leslie Jordan
Nicholas Katzenbach
Anna Kendrick
Caroline Kennedy
Patrick Kennedy
Ted Kennedy
John Kerry
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Coretta Scott King
Gayle King
T.R. Knight
Rabbi Peter Knobel
Jim Kolbe
Liz Krueger
Dennis Kucinich
Lisa Kudrow
Tony Kushner
Lady Gaga
Padma Lakshmi
Nathan Lane
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Convert OST Outlook 2010 in System Utilities / File & Disk Management
If your Exchange Server user as yet your Exchange OST file gets corrupt due to highly corruption then try OST converter software of PCVITA which is most popular tool to recover OST file completely. This OST converter software easily recover OST file as yet convert OST file Outlook 2010. The OST converter software convert OST Outlook 2010 including email, contacts, calendars, journal, task etc. This software easily support entire Exchange Server editions as yet convert OST Outlook 2010, 2007 and 2003. You can try free demo version of OST converter software which is free to evaluate as yet allows to convert 5 OST file items FREE. If you need to convert complete OST file components then you have to buy full version of OST converter software. Full version of OST converter is available at only $99.
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text:
Neverwinter's Control Wizard flexes its magical fury to control battles and damage enemies in a new montage trailer.
Valindra Shadowmantle raises an undead army to wage war against the living in new Neverwinter trailer.
Neverwinter will open up for its second closed beta event this weekend. Get all the details after the jump.
Dwarves, ice giants, frost goblins, and more fight it out in Neverwinter's wintery cold zone of Icespire Peak.
Neverwinter's Great Weapon Fighter will be available to play for attendees at PAX East along with a few other surprises.
Perfect World delves into the design of mounts and their various incarnations in the realm of Neverwinter.
Neverwinter's new trailer reveals a look at the one enemy that all fantasy games must have – the orcs.
Get a look at Neverwinter's Devoted Cleric in action and try it out this weekend during the first beta event.
Neverwinter's first Beta Weekend starts Friday and Cryptic has unleashed the third "Siege of Neverwinter" trailer ahead of the event.
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text:
Brooklyn Zine Fest
Various venues
Until Sun Apr 27
- Free
Photograph: Jessica Lin
Time Out says
Posted: Mon Apr 9 2012
Some say print media is dying a slow, ignominious death (we respectfully disagree), but the self-publishing scene is undeniably thriving. Whether out of nostalgia, vanity or boredom, folks are printing pamphlet-size periodicals by the ream (remember those?). As one of the form's strongest champions, the Brooklyn Zine Fest has established itself in three short years as a publishing expo par excellence. The two-day affair takes over the Brooklyn Historical Society, with 154 creators from around the world, including plenty from the five boroughs, filing in to sell their wares. Here's a selection of our favorites. As a warm-up to the fair, the venue hosts a panel discussion, "Zines from the Borderlands: Storytelling About Mixed-Heritage," on Thursday 24 at 7pm (free) and Chicago-based performative-reading event Brain Frame on Friday 25 at 8pm ($8).
ReviewsAdd +


text:
When it comes to finding a career that's right for you and good for the world, you have to know your strengths. A key to the success of our Echoing Green Fellows, for example, is their ability to uncover and focus on what they rock at. (They often fill in the holes in their expertise by supplementing them with talented people on their team.) It's a simple formula for impact. With that in mind, we want to know, what are you good at?
Photo: joelkelly
I am good at vividly painting pictures in my mind. Although these pictures may often represent anxious thoughts, or be my window of escape from unpleasantries in the world around me, I create alternate visions that feel as real as the world around me. I am, and have always been a dreamer. I am also an eternal optimist. I firmly believe that every experience that we have was meant to happen for a very specific reason. With that in mind, I always look for the sweetness that is knowledge in every situation. If you have a positive outlook on life, you are always ready to make the most of any situation. We only have one life to live, so why not soak up all the sun and reap all the sweetness there is to reap?


text:
Show Preview: Amputees and She Sir @ Hotel Vegas – Tonight!
|Thursday, January 16th
|Hotel Vegas
Looking at this show line-up, attending this set on a Thursday night seems like a no-brainer to me. You get the Amputees, who will be playing a three day residency in Austin, plus other really incredible acts that should already be on your radar at this point. There's She Sir, who we've already told you are set for a big year with their up-copming release, Go Guitars. And, you'll get to see Ruby Fray, who won tons of people over during her Free Week appearances, so there's really no reason to skip it. Make it a fun night, and hit up the show.
Download: She Sir – You Could Be Tiger [MP3]


text:
The Burbank Tournament of Roses Association's website has a page dedicated to the process from the point Richard Burrow submitted the original design to where it is now. The page also congratulates him for being picked. See the page by visiting burbankrosefloat.com/history/2013/2013float.html.
The Pasadena Tournament of Roses airs on local television channels on New Year's Day.
Read the Register's first story on Burrow here: ocregister.com/news/burrow-344634-float-parade.html.
MISSION VIEJO – Richard Burrow has always had a creative side. It's a side that let him down many times, but he never gave up on it.
Almost 30 years later, his determination is paying off.
On New Year's Day, a Rose Parade float based on his design of a girl piloting a submarine on a journey undersea, built for the Burbank Tournament of Roses Association, will glide down the streets of Pasadena.
The theme of the 2013 Pasadena Tournament of Roses is "Oh the Places You'll Go!" based on Dr. Seuss' book.
In 1983, while a student at Cal Poly Pomona, Burrow submitted a Rose Parade float design to the school's Rose Float club, which works with a group from Cal Poly San Luis Obispo to design and built a Rose Parade float every year.
Though Burrow was a member of the club, his design was turned down.
He moved on, built a family and a career as an architect, but kept watching the Tournament of Roses every first day of each year, he said.
His job as an architect gave him some room for creativity. Burrow, 53, said he once entered a competition to design a Christmas card for his company and his sketch won the judges' hearts.
His duty as a father, too, led him to use his imagination. He designed his family's baby announcements, he said.
But as the years went by and as the economy slowed down, he longed for a project to heighten his imagination.
"I like to create things," Burrow said. "And lately, I haven't had that many original design opportunities ... and I've been praying to God to give me a design opportunity to do something. I missed that creative part."
Burrow submitted three designs to Cal Poly Pomona in 2011 for the 2012 Rose Parade. Once again, he was turned down.
"I was disappointed, but I thought, 'I will try again,'" Burrow said. "I think that some of the designs that I had come up with were good. I felt confident that they were good."
This year, he submitted his design to the Burbank Tournament of Roses Association, which is one of the few parade participants that solicit designs from the public and build their own floats, he said. He also submitted two other designs to South Pasadena and Sierra Madre, he said.
Burrow learned in February that his design won preliminary approval by the Burbank association.
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text:
Galena Discloses SEC Investigation Focused on Stock-Touting Campaign
LAKE OSWEGO, Oregon (TheStreet) -- Galena Biopharma (GALE) is under a federal investigation by the Securities and Exchange Commission, according to regulatory filing Monday night.
"In February 2014, we learned that the SEC is investigating certain matters relating to our company and an outside investor-relations firm that we retained in 2013. We have been in contact with the SEC staff through our counsel and are cooperating with the investigation," Galena disclosed in its 10-K Monday night.
Galena shares are down 16.5% to $2.68 in Tuesday trading.
On Feb. 12, TheStreet published a story documenting how Galena paid an investor relations firm, The DreamTeam Group, to engage in a stock-promotion campaign on behalf of the company. The DreamTeam's work for Galena included publishing promotional articles written under false names on the investor web site Seeking Alpha.
Aided by this promotional campaign, Galena shares tripled in value from last summer. Coincidence or not, Galena insiders, including CEO Mark Ahn, made millions of dollars by selling company stock in January.
In addition to the SEC investigation, five lawsuits have been filed against Galena in federal and state court, accusing the company of violating federal securities laws and breaching fiduciary duties. All the lawsuits pertain to Galena's involvement in the stock-promotion campaign and the insider stock sales.
"Based on the very early stage of the litigation, it is not possible to estimate the amount or range of possible loss that might result from an adverse judgment or a settlement of these matters," Galena said in its 10-K.
Galena also issued a statement: "We intend to vigorously defend against the recent claims against us, and recognizing the impact that it has had on our shareholders, we are taking every possible step to address the situation," said Ahn.
Irving Einhorn, a former SEC enforcement attorney, was appointed to Galena's board of directors, the company said.
Net sales of the cancer pain drug Abstral were $1.3 million in the fourth quarter, below analyst consensus expectations of $1.8 million. Galena forecast 2014 Abstral sales in the range of $11-15 million, which brackets current consensus expectations of $12.3 million.
Net loss for the fourth quarter was $48.5 million, including $38.9 million in non-cash charges.
-- Reported by Adam Feuerstein.
Follow Adam Feuerstein on Twitter.
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Description & HighlightsBe the first to Write a Review
Metrokane Barware in Stainless Steel and Faux Black Leather
Metrokane introduces their new VIP barware collection that combines the eye-catching shine of stainless steel with the rich look of leather. Crafted from 18/8 stainless steel, the VIP Bar Tool Set includes all the tools you need for a complete home bar.
The tools and stand are wrapped with fine-stitched faux black leather.
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The tools and stand are wrapped with fine-stitched faux black leather.
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