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Alopecia Areata Clinical/Translational Research Summit met at Columbia University in New York City on October 22, 2010. The purpose of this summit was to discuss the need for new treatments in alopecia areata patients, to discuss new scientific and translational opportunities that point to new therapies, and to develop a strategy to bring new therapies to clinical trial, and eventually to clinical use in patients with alopecia areata.
Attendees at the summit, front row: Angela Christiano, Vera Price, David Norris, Maria Hordinsky, Wilma Bergfeld. Middle row: Jeff Frelinger, Jenna O'Neill, Marc Glashofer, Jerry Shapiro, Amy McMichael, Elise Olsen, Lynn Petukhova. Back row: Ricardo Cibotti, Carl Baker, Hsin-Pei Shih, Raphael Clynes, David Whiting, Timothy Wiedmann, Irv Katz, Gary Gordon, Howard Fleit, Maureen McGettigan, Julian Mackay-Wiggan
1. The need for treatments for alopecia areata and quality of life issues to prove that need. Review of past clinical studies of alopecia areata to see what worked and what did not work.
As clearly stated by Maria Hordinsky, Hordinsky: "Patient groups are demanding more!!!" The Mission of the Alopecia Areata Clinical Research Task Force is to "Fast track" possible treatments that are both effective and safe. Members of the team are already investigating new promising approaches: Excimer laser (McMichael), Targretin (Duvic), Zithranol (Shapiro), new autoimmune therapies (multiple investigators). Wilma Bergfeld reported that previous Quality of Life ( QOL) investigations have shown that alopecia areata produces significant psychological distress, body image distortion, and dissatisfaction with the treatments and information available. Maria Hordinsky reported that the QOL data obtained by the National Alopecia Areata Registry is now being organized and studied, and shows that the patients perceive that alopecia areata is a significant problem for them. She feels that the alopecia areata QOL data must be compared to results in patients with chronic diseases affecting other organ systems.
Over the past five years, significant effort has been invested in studying promising therapies including modern biologics as treatments for alopecia areata. Vera Price reviewed the outstanding Efalizumab (Raptiva) study, which measured hair regrowth, QOL, and physician and patient assessment. It was expected that this drug, which inhibits T cell function, would be effective in alopecia areata; unfortunately, it showed no effect. Bruce Strober reviewed an alopecia areata clinical trial with Alefacept (Amevive) a soluble LFA3 that inhibits T cell function. Even though the trial showed decreases in circulating T cell levels, there was no effect on hair regrowth in alopecia areata patients. Further trials with the TNF-a inhibitor Etanercept (Enbrel) were also negative. Neither anti-T cell or anti-TNF drugs produced significant responses in alopecia areata.
There was considerable discussion about why these trials were not effective in regrowing hair in alopecia areata. Some suspected that study of AU or AT patients may have been too difficult a challenge; patchy persistent disease might be more appropriate for initial trials (50-75% hair loss on the scalp). Maria Hordinsky felt that prior biopsies establishing the inflammatory phase of alopecia areata are necessary before instituting immunosuppressive drugs. Angela Christiano suggested that studies might need a hedgehog agonsist to stimulate anagen follicle activation. Wilma Bergfeld added that minoxidil might need to be added as an accelerator. David Whiting felt that patients needed to be staged as acute, subacute and chronic before enrollment in studies. It is evident that there is still disagreement on the best clinical stage of disease to enroll in modern treatment protocols
2. Insights into immune targets for alopecia areata to see what drugs might be possible candidates to study
Raphael Clynes provided a detailed discussion of the best drug targets in autoimmunity, and began the discussion of which immune pathways should be targeted in alopecia areata. Three cellular targets are evident from modern research in alopecia areata, and each can be targeted through specific protein or signaling pathways: Innate/NKG2D response (UBLP3, UBLP6, MICA), antigen presenting cells/sentinel (HLA, TAP, IFN-, Adaptive immunity (CTLA4, iCOS, IL-2, IL2R, IL-21). IL-15 drives the NKG2d axis and may itself be a good target. Most of the genes upregulated in alopecia areata at IFN- response genes, so blocking IFN-g effects is a logical approach. CTLA4 inhibition may enhance T reg suppressor cells, inhibit TH1 cytokines, and inhibit CTL – which would block the immune response in alopecia areata. Jak inhibitors might block TH1 cytokines that drive alopecia areata. These treatments fall into 3 broad categories: Blocking natural killer innate immunity, putting the brakes on activated T cells, and jamming the inflammatory cytokine network. These approaches are being used effectively in many autoimmune diseases.
3.New drug treatment opportunities based on the results of Dr. Christiano's genetic studies
Angela Christiano noted that the recently published alopecia areata GWAS study noted 8 strong drugable targets. Outside of HLA loci, these targets were not strongly shared with other autoimmune diseases. Type I diabetes, celiac disease and rheumatoid arthritis all share one NK locus with alopecia areata. She feels that NK-related genes provide some of the most promising targets for future treatment
4. New treatment opportunities based on drugs being developed for other autoimmune diseases
Based on our current knowledge of the genetics and immunology of alopecia areata, there are multiple drugs currently being evaluated for other autoimmune diseases that might be very effective in alopecia areata. Elise Olsen reviewed the possible drug candidates available for topical and systemic use and discussed some of the pitfalls facing drug development in alopecia areata. To repurpose FDA approved drugs, we would need to perform fairly large clinical trials because of the large spontaneous remission rate in alopecia areata. For drugs that are not yet FDA approved, selection of drugs in Phase III of development would be most practical. She also noted that we need better consideration of topical agents such as topical nitrogen mustard, cyclosporine, or imiquimod.
From the discussions of the day, a number of approaches would be reasonable choices for clinical trials in alopecia areata; all of these have drugs in development or already FDA approved:a. Anti CD25: kills activated T cellsb. Anti-CTLA-4 blocks CD86-dependent activation of APCc. Jak 1/2 inhibitor: blocks TH1 responsed. Anti-NKG2D- inhibits natural killer cellse. Syk inhibitor f. Anti-IL-15g. Anti-IL-6 h. Anti-IFNi. Anti-TAP2 (Sundberg mouse model)j. Anti IL-1k. Anti-IL-17l. Anti-PDE4
Most of these are antibodies or peptides that block specific immune functions. Small molecule inhibitors of targets such as Jak and Syk may be ideal drugs for topical use because of their small size and lack of polarity.
5. New treatment opportunities for devices and drugs that might work for alopecia areata patients Amy McMichael reviewed additional approaches that might be effective. Light therapies have been proposed for alopecia areata for years, with questionable effectiveness. New photodynamic therapy using Levulan and blue light is ineffective. However, the Excimer laser is a promising approach, effectives in small pilot studies, that needs further investigation.
6. Review of different drug delivery systems Timothy Wiedmann reviewed the issues involved in drug delivery for topical agents in alopecia areata. Existing means of delivery may be appropriate for small molecules, but larger polar molecules will need enhanced delivery systems, preferably through the hair follicle. Antibodies or peptides will be difficult to deliver unless new approaches are developed for follicular delivery. The practicality of systemic drug delivery will depend on the balance of benefit and risk.
8. How to standardize all future alopecia areata clinical trails in organization, selection of patients, and regrowth measurement. Irv Katz and Jerry Shapiro reviewed the issues involved in clinical trial design and execution in alopecia areata. It is clear that previous studies in alopecia areata have been inadequate; a recent Cochrane review concluded that there is no convincing evidence of lasting effect of any treatment in alopecia areata. It is clear that we need to have better standardized trial design with unambiguous and reliable endpoints, physician and patient evaluations of effect, and biomarkers to quantitate effectiveness.
Although open pilot studies may provide useful information on effectiveness of promising drugs, randomized clinical trial with large numbers are necessary to establish drug effectiveness. "Half-head" topical trials are a unique advantage of alopecia areata as a model for drug assessment and should be more widely used.
9. Session VI: Future Directions David Norris led a discussion of the elements of the meeting, the conclusions reached, and future directions. This included assignments of tasks to the participants.
1. Multiple highly promising drugs are available for testing in alopecia areata, based on findings of the recent GWAS study and on drugs available from other autoimmune disease programs.2. There are abundant excellent choices for topical and systemic therapy for alopecia areata, but we cannot afford another clinical trial from which we learn nothing. 3. The alopecia areata research community lacks a uniform clinical research protocol with validated biomarkers to study clinical and mechanistic response to treatment. 4. We need an alopecia areata biobank with tissues available for study.5. The Cochrane review on alopecia areata treatments did not give proper consideration to "half head" studies that show effectiveness for topical diphencyprone contact sensitization therapy. Such studies will be useful in assessing future topical treatments for alopecia areata.6. Well coordinated multi-center trials using a robust clinical trial protocol with excellent biomarkers and unambiguous endpoints are essential in establishing the safety and efficacy of new drugs for use in treating alopecia areata.
1. Produce the Summary of the Summit to be submitted for publication, submission to drug companies, and NAAF donors. Dr. Norris2. Mine the National Alopecia Areata Registry data and publish quality of life data on alopecia areata. (How does alopecia areata quality of life compare to liver and heart disease patients quality of life? If disease is observable metrics have to be compared to controls) Drs. Duvic and Hordinsky3. Develop a uniform alopecia areata clinical protocol: (Stratify extent, duration. Have crossover component. Develop case report booklets. Design must have an unambiguous end point.) Drs Shapiro and Bergfeld4. Research the literature for all alopecia areata biomarkers and submit a paper for publication. Drs Katz and Hordinsky5. Research and submit to the task force the biomarkers from the Raptiva study: Drs. Price and Whiting.6. Develop a plan for developing a translational platform with biomarkers (Skin, serum, whole blood, RNA, DNA) Drs. Clynes and Christiano7. Develop a plan for approaching the 22 pharmaceutical companies developing drugs that need to be pursued for alopecia areata. McMichael, Kalabokes et al8. Apply for the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Clinical Pilot and Feasibility Studies. Dr. Christiano for November 18 deadline and future submissions not determined as of yet. 9. Schedule regular meetings of the Alopecia Areata Clinical Task Force. Kalabokes10. Change the name of the registry in October 2011 to Alopecia Areata Clinical Trials Registry – Dr. Duvic and Kalabokes


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What do you think of airborne?
- 0Does anyone think airborne improves your chances of not getting viral infections? Has anyone used it with success? Thanks for any input.
- 0Oct 4, '05 by MrsWampthangI have taken it during cold and flu season in the ER and it seemed to really help me not to catch those. Or if I seemed to be coming down with either, I took it as directed on the bottle and the symptoms seemed to go away. Anyway, I liked it.
- 0Oct 11, '05 by NewEnglandRNI love Airborne. It seems to work well on minor colds, but if it's a biggie (like I had last week), it did not do much.
I take it before I go to clinicals 2 days/ week and if I feel like I am coming down with something.
- 0Oct 11, '05 by DutchgirlRNA good friend told me about Airborne just last week and then I saw it at Wally World. I've got the a HA and sore throat this morning. I work Thur & Fri . I better make a run to Wally World. Thanks !

subset: commoncrawl


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main index
She take my money when I'm in needThis is a character who hooks up with a partner, known as a Meal Ticket or Sugar Daddy, specifically to mooch off of said partner's money and status (usually in exchange for sex.) We use "she" because the digger is usually female in modern shows, but not always, and often MUCH more attractive than her partner. Often Distracted by the Luxury quite easily. Generally stunningly beautiful, to explain her success. Often a blonde whose hair is dyed. The golddigger who is deluding herself about her looks is a rarity. Many a golddigger would be happy to marry a man who is old or in bad health, just so long as he'd be so kind as to leave at least some of his inheritance to his spouse when he dies; if she's a Black Widow that could happen much sooner than expected. A common subversion is to have her turn out to a Hooker with a Heart of Gold after all. Another way that works play with this is to have a rich man pretending to be poor, so as to ensure that any woman he becomes involved with loves him for himself and not his money. Yet another way to play with it is to have her genuinely fall in love with her meal ticket. When it comes to interacting with people other than their Meal Ticket, golddiggers are often extremely self-centred, vain, manipulative and bitchy Socialites with no other goal in their life than pampering themselves and buying whichever catches their fancy. In historical eras, male "fortune hunters" were much more common, owing to the bride's lack of say in the matter. This was particularly common in Victorian Britain, when many Peers found that their old way of life had become insufficient to support their way of life (particularly their country estates): their primary source of income had been agriculture, but the main crop (grain) could be far more cheaply grown in the United States, Canada, Russia, and (later) Australia, so the aristocrats (after trying and failing to fix their problem with protectionism) were priced out of the market and started losing income. As a result, many young British nobles married the daughters of self-made industrialists and merchants (who had previously been seen as too low-class for the upper crust to marry), particularly American ones.For instance The Other Wiki even has a list. Another male variant exists in the Japanese Visual Kei subculture: Visual Kei artists, especially lifestylers or current or ex-Delinquents, are almost unemployable outside of their own industry in a culture dependent on conformity as a requisite of traditional employment. As a result, quite a few indies, beginning, or unsuccessful artists will work in a Host Club and/or seek out a mitsukano or mitsukare ("honey woman" or "honey man") to provide for them on a financial level. This is Older Than Steam. Compare Rich Suitor, Poor Suitor. See also Trophy Wife, although the two don't always overlap. Sometimes overlaps with Coattail-Riding Relative. For the opposite type of character, who definitely does not want the rich beau's money, see Not With Them For The Money. Contrast Marry for Love. The idea that all women are golddiggers is the Distaff Counterpart to the idea that All Men Are Perverts. This may also overlap with All Women Are Prudes, resulting in the idea that the only reason women ever have sex is to gain access to a man's money and/or get men to buy them things, while the only reason men even bother to make money in the first place is so that they can have sex with lots of hot women. Important Note: A golddigger is never a Housewife. While both of them stay home, the golddigger has expensive tastes and refuses to dirty her hands. Children and family are almost never part of her priorities, mostly because they would distract her from her life of luxury; though a divorcing golddigger will use the kids as bargaining chips to gain as much money as possible (often seeking to be the custodial parent) without regard for the children's best interests and often without any real affection for the children. The Housewife on the other hand, even though she may live off her husband's paycheck, will concern herself with running the home and raising the kids, money and luxury usually not being in her repertoire other than as byproducts. A golddigger MIGHT turn into a housewife given proper character development. For the comic book series, see Gold Digger. For the people who make a living actually digging up gold, see Prospector.
Yeah, she's a triflin' friend indeed.
She's a gold digger way over town
That digs on me.
— Kanye West ft. Jamie Foxx, "Gold Digger"
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Bataleon at Superpark 18
Jaeger Bailey, Shaun Murphy, Mitch Richmond, and Tor Lundstrom.Read More
Jaeger Bailey, Shaun Murphy, Mitch Richmond, and Tor Lundstrom.Read More
This weeks edit comes all the way from Japan by Amane Ohta.Read More
Superpark Sundays are back and this week's video comes from Alex Martini.Read More
This edit features some serious shots with Superpark 13's heavy hitters. Our man Gary Tyler McLeod captured Lonnie Kauk and Chelone Miller smashing the LOONatic jump, Nico Cioffi getting nasty in the Bear bowl, Austin Hironaka doing his thing on the big hip and that's just for starters. Don't believe us? Watch this edit and you'll be converted.Read More
Our very own Snowboarder Magazine editor Pat Bridges sat down to give us his take on the 13th annual Superpark presented by Gatorade.Read More
3 days of big lips, fast laps, hot landings and high airs took their toll on the majority of the Superpark 13 presented by Gatorade attendants, leaving an abridged field on hill for day four. With less talent on tap, the invited industry members and media had the perfect opportunity to get some of their own.Read More
Clayton Shoemaker and the Bear Mountain crew finally cut the ribbon on their main feature; a perfectly shaped half-bowl with hips into either side and a giant cheese wedge dead center in case you want to send it over the whole thing.Read More
Superparkers who showed up to Superpark 13 presented by Gatorade Day 3 were treated to the nicest conditions of the week, with blue skies and very little wind, it was go time.Read More
As far as action was concerned, the extra large Loon jump saw more hits than a battered housewife and the opening of the extra large hip was a ceremony not to be missed. These day 2 photos of Superpark 13 presented by Gatorade are well, super.Read More
A massive hip finally reached completion after 37 straight hours put in by Pete Colombo and crew on day two of Superpark 13 presented by Gatorade. Once the call was made riders started low, creeping higher and higher up the drop in, and eventually were blowing past the 25-foot high Gatorade measuring stick. The hip itself is parallel with a 50-foot high lift tower to give you some perspective. We caught up with Jake Welch and Pat Moore at the end of the day to get a little insight on the hip "warm up" session.Read More


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Deputies serve the community in more ways than one. Each year, as part of the Tip-a-Cop event, deputies join Red Robin wait staff to serve meals and solicit tips from patrons to benefit Special Olympics. Deputies wear aprons over their uniforms and greet customers during their restaurant visit.
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Definitions for hockey team
This page provides all possible meanings and translations of the word hockey team
Princeton's WordNet
hockey team(noun)
a team that plays ice hockey
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Denver's Info...
I am already neutered, up to date with shots, and good with cats.
Denver is my name and I am looking for a loving home where i can share my sweet purrrrsonality. It takes me a little time to warm up to new people but once you share some treats and we talk i will be won over . I look almost identical to my brother Dallas - so if you are looking for a pair of kitties we would be a cool addition to any home. Please consider a sweet boy like me to join your family.
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About Our Shelter...Brigid's Crossing Foundation is a unique, non-profit, cat rescue & healing sanctuary in Naples, Florida. We are a no-cage, no-kill, nature-oriented center. We are focused on the rescue and care of homeless, sick and abandoned animals while teaching about the path of service and the ways in which it enhances life.
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People who live in a Niagara County mobile home park are crying foul over the foul sight and smell of sewage overflowing in their yards. YNN's Antoinette DelBel reports on the response to the findings.
RANSOMVILLE, N.Y. - Residents of Dorwood Mobile Home Park maintain the bubbling water near their homes is sewage overflowing from a septic tank.
"These are cisterns (septics)," said Stephen Farrell, a tenant. "It has a small leach field, and the leach field's not big enough to hold the amount of sewage that comes from both mobile homes."
Farrell moved into Dorwood Park in Ransomville three years ago. He claims the park's septic system has not been maintained, causing unsanitary conditions.
"There was an open cesspool next to my house for a year and a half," he said. "I stepped in it while mowing the guy's lawn and had to throw away my shoes. They finally fixed it this past year, but after a year and a half, the septic system was pouring all over the yard, you could smell it from houses away."
Dorwood resident Deborah Stewart tells a similar story: septic problems since last spring. "I've been here for seven years and three months and they've never ever looked at my septic," said Stewart. "I can smell all the sewage coming up out of my bathroom, the toilet, the sink."
Stewart showed us her property Thursday morning and said the park's maintenance crew was notified about it three weeks ago. After YNN left her house Thursday afternoon, she told us a crew then came out to fix it.
"They have to dig down to the transfer box, pull the transfer box apart and then stick the hose in there to clean it and then put it back on," said Farrell. "So what they do is they wait until it blows the transfer casing, floods the yard." "Sewage is potentially harmful to humans," said Niagara County Supervising Public Health Engineer Paul Dicky. "There's bacteria within the sewage that could cause different gastrointestinal illnesses."
We're told an inspector from the Niagara County Health Department found ground sewage on site last December, but says there was no evidence of a failing tank and maintenance fixed the septic system the next day.
According to the health department, as long as the system is functional, it does not have to be replaced with current design standards.
"This park was approved in 1958, so the sewer systems that are in there are probably dating back as far as that time," said Dicky. "If the system fails and it needs to be remediated or altered in some manner, then those current standards would have to be applied to it."
Not all who live at Dorwood share the concern.
"I don't smell any sewage, so I would assume we're not having any septic problems," said resident Michael Brungardt.
We spoke with the park's property manager. She did not want to go on camera and said she didn't have a comment at this time.
YNN also reached out to the park's owner in New Jersey for comment. He did not return our calls.
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Player Valuation: £750k, from GPS signal lost
**swings thru**
Yeah I read their grovelling apology. I've got no right to complain. I don't pay. It's just take, take, take with me. I'm off to bed. That took far longer then anticipated so max rep for the previews. They must take a while. Take it easy.
No worries, my previews are usually full of such stuff!
They've had to reset the forum like, they'll have it sorted in a couple of days like, usually happens on transfer deadline day but they're hard at work like.
A bit of chaos is good for the soul mate.
Hahaha. I keep them down on the sly mate.
Really sound report, lids like stuff like that especially our lids who live in different countries. Gives them the authentic feel of the match. Nice one.
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News » Published 2 weeks ago
Is this Scarlett Johansson the Actor?
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11th December 2014 @ 12:03pm
Hollywood superstar Scarlett Johansson has revealed how she is working hard to get her post-baby body back to its best
19th November 2014 @ 09:49pm
Scarlett Johansson is one of the best actresses in the world but she has yet to get nominated for an Oscar so will we ever see her win one?
PAST NEWS Scarlett Johansson shows off new tattoo
25th April 2012 @ 11:52am
Actress Scarlett Johansson is so proud of her roots in the Big Apple, she's had a new tattoo on her wrist to proclaim her love for the city.


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Hotel fires person who recorded Jay Z attack video
NEW YORK (AP) — A hotel where someone recorded security video appearing to show Beyonce's sister, Solange Knowles, attacking Jay Z inside an elevator said…
NEW YORK (AP) — A hotel where someone recorded security video appearing to show Beyonce's sister, Solange Knowles, attacking Jay Z inside an elevator said…
An Ohio County Sherriff Department deputy secures an area in front of the Federal Buildng in Wheeling, West Virginia Wedneday, Oct. 9, 2013, following a shooting outside the courthouse. (AP Photo/Wheeling News Register & The Intelligencer, Scott McCloskey) by Vicki Smith Associated Press Writer WHEELING, W.Va. (AP) — Security was tight Thursday at a West Virginia federal courthouse, a day after it was peppered with gunfire by an ex-police officer who neighbors say had recently revealed that he had cancer.
Mary Italo, center, grieves with other relatives for her son Thomas Abayo Italo, 33, who was killed in the Westgate Mall attack, as they wait to receive his body at the mortuary in Nairobi, Kenya Wednesday, Sept. 25, 2013. Thomas was an accountant and the breadwinner of the family who helped look after Mary who is sick, according to relatives. (AP Photo/Ben Curtis) by Jason Straziuso, Andrew O. Selsky, and Tom Odula Associated Press Writers NAIROBI, Kenya (AP) — Working near bodies crushed by rubble in a bullet-scarred, scorched mall, FBI agents began fingerprint, DNA and ballistic analysis Wednesday to help determine the identities and nationalities of victims and al-Shabab gunmen who attacked the shopping center, killing more than 60 people.
MEXICO CITY — Malcolm Shabazz, grandson of political activist Malcolm X, died in Mexico City after a violent dispute in a bar, Mexican authorities said Friday. He was 28.
By LZ Granderson GRAND RAPIDS, Michigan (CNN) — If September 11, 2001, was the day everything changed, then April 15, 2013, serves as another reminder of that change, of our frailties and of a new reality in which "it can't happen here" has been replaced by "it can happen anywhere."
DOCKED–The cruise ship Carnival Triumph is moored at a dock in Mobile, Ala., Friday, Feb. 15. (AP Photo/Dave Martin) by Brendan FarringtonAssociated Press WriterMOBILE, Ala. (AP) — When their cruise ship lost power, passengers aboard the Carnival Triumph could have been selfish and looked out only for themselves and their loved ones.Instead, they became comrades in a long, exhausting struggle to get home.
CHARRED REMAINS–In this aerial photo, law enforcement authorities investigate the charred remains of a cabin Wednesday, Feb. 13, 2013, where quadruple-murder suspect Christopher Dorner is believed to have died after barricading himself inside during a Tuesday stand-off with police in the Angeles Oaks area of Big Bear, Calif. (AP Photo/The Sun, John Valenzuela) by Greg Risling Associated Press Writer LOS ANGELES (AP) — He styled himself as a Rambo-like guerrilla, someone trained to outwit and outshoot the police at every turn, and while Christopher Dorner left no doubt he could be unforgivingly violent, when it came to keeping ahead of the law during his deadly rampage, he made one mistake after another. The last one — letting one of two people he tied up get to her cellphone and call police as he made off in their purple car — tipped authorities he was coming.
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Four million people die annually from smoke inhalation caused by cooking meals. Two Irvine Valley College students invented a stove to help.
Comments are encouraged, but you must follow our User Agreement
Keep it civil and stay on topic. No profanity, vulgarity, racial slurs or personal attacks. People who harass others or joke about tragedies will be blocked. By posting your comment, you agree to allow Orange County Register Communications, Inc. the right to republish your name and comment in additional Register publications without any notification or payment.


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Establishing the Digital Rate Card
Early adopters share how they've determined value for digital editions.
Digital editions have been positioned as value-added for so long that first attempts at developing an advertising rate card can leave publishers at a loss.
Some publishers don't charge for ads but do charge for extra features (including making ad links live, something some digital vendors frown at). "It is very rare we will offer advertising in a digital edition only," says Graduate Prospects sales director Allan Brown. "If the paper product is the lead we tend to add in the digital as part of the package at no cost (added value) for a straight replica of the ad. Then we up-sell features in the digital edition such as animation."
When digital editions are the lead, Brown says he can charge higher rates for that than other online products.
ITEM Publications' Interference Technology has several digital editions for the Asian market. All ads from the print product are featured in the digital edition but only those advertisers paying a 12 percent optional premium of the print are included in search results and receive reader tracking.
Charging on a CPM basis is risky, since digital editions typically have fewer readers than Web sites (although vendors claim readers are more engaged). When skateboard title SLAP went all digital, the publisher tried to get print advertisers to commit to spending the same monthly ad dollars based on a industry standard, impression-based CPM. "We had a huge amount of Web traffic already in place that easily ate up all those impressions," wrote group creative director Kevin Convertito on FOLIO:'s mediaPRO social network earlier this year. "If you don't already have a Web presence and active community, you probably can't afford to go that route."
Pricing can also depend on the digital format, such as the flip-page style or a vertical scrolling HTML. "For high-traffic, HTML-based sites, you could sell a combo of impression-based, click-through, and time-based sponsored rates, but for smaller, niche stuff in the page-flip format you'd probably do better to try and sell added value like active links and embedded video for much higher CPMs," Convertito added.


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Link: GAO Opinion Agency: Department of the Air Force Disposition: Protest denied. General Counsel P.C. Highlight: GAO denied the protest of Security Management and Integration, Inc. (SMI), based on the rejection of its proposal under a request for proposals (RFP), issued by the Department of the Air Force for mess...Read more
Tennier Industries, Inc., B-403943.2, June 29, 2012
Link: GAO Decision
Protestor: Tennier Industries, Inc.
Agency: Defense Logistics Agency; Small Business Administration
Disposition: Protest Denied.
GAO Digest:
- Protest that Department of Defense agency improperly...
NSR Solutions, Inc., B-406337, B-406337.2, April 18, 2012
Link: GAO Decision
Protestor: NSR Solutions, Inc.
Agency: National Aeronautics and Space Administration
Disposition: Protest Denied.
GAO Digest:
Read more
Explo Systems, Inc., B-404952; B-404952.2, July 8, 2011
Link: GAO Opinion Agency: Department of the Army Disposition: Protest sustained in part, denied in part. Keywords: HUBZone Price Preference General Counsel P.C. Highlight: In a procurement not set aside for HUBZone companies, that procuring agency shall give offers from HUBZone small business concerns a price evaluation preference...Read more


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Villa Cvita Hvar
Official Contact Details - Villa CvitaPhone: ++ 385 21 77 80 80 Fax: ++ 385 21 77 80 81
Villa with pool in Hvar town, Croatia. Nicely arranged with full comfort. Close to the sea in calm environment. 15 minutes walking distance from the city center.
- Price from 297 EUR / Day
- Capacity up to 8 people
- 4 bedrooms & 3 bathrooms
(click on a photo to view it)
Last updated: 01/15/2008
This is your property ?
Villa Cvita is composed of four bedrooms, four bathrooms of which 3 ensuite, spacious kitchen dining and living room and nice exterior terrace with garden furniture and swimming pool.
Villa Cvita is situated in a calm neighborhood less than 50 m from the sea and 15 minutes walking distance from the animated Hvar city center.
Prices & deals
- Lowest Daily Price:
- Highest Daily Price:
- Lowest Weekly Price:
- Highest Weekly Price:
- Cleaning fee:
- Charging Method:
- Payment Types:
- Cash
- Credit Card
- Cheque
- Travellers cheque
- Paypal
- Wire Transfer
Location & area
Villa Cvita is situated in calm west part of the Hvar city Hvar. Near the sea, within walking distance from the city center, restaurants, bars and cultural activities.
- Address:
- Majerovica, 21450, Hvar, Croatia
- Accommodation located in:
- coastal, near cultural interest, near diving spot, near fishing area, near historical interest, near restaurants & bars, near tennis courts, near the beach, near water sports, resort, town, waterfront!
Amenities & services
Villa Cvita is equipped with fully attention of guests comfort.
The kitchen equipment is complete and includes a coffee machine, toaster, electric kettle, electric lemon squeezer, kitchen mixer, full ceramic service, different type of wine, champagne and water glasses and full fish and meat cutlery.
The living room is equipped with flat screen TV, DVD and HIFI equipment. The guests of villa Cvita have direct telephone line to the house and possibility of Internet connection without additional charges.
The complete house is equipped with air condition (including heating).
Villa Cvita's guests receive daily cleaning services and daily exchange of towels. Laundry service is on extra charge (except for house bed linen and towels).
# of Units: 1... and each unit includes:
- Bedrooms: 4
- Bathrooms: 3
- Single beds: 4
- Double beds: 2
- Baby cots: 1
- Single sofa beds: 0
- Double sofa beds: 1
- Towels:
- Bath:
- Hair Drier:
- Shower:
- DVD Player:
- Fax:
- Washing Machine:
- Work Desk:
- Bed Sheets:
- Bikes:
- Cable/Satelite TV:
- Internet Broadband:
- Internet Dial Up:
- Ironing Board:
- Library:
- Stereo/Radio System:
- Telephone:
- 24h Concierge:
- Tours & Excursions:
- Butler Service:
- House Chef:
- Local Guides:
- Local Transportation:
- Microwave:
- Oven:
- American Kitchen:
- Fridge & Freezer:
- Crockery & Utensils:
- Dish Washer:
Living room
- Fireplace:
- Sofa Bed:
- Table & Chairs:
- Tennis Court:
- Terrace:
- Parking:
- Pets Welcome:
- Private Beach:
- Barbecue:
- Garden:
- Sauna:
- Shared Bathroom:
- Spa / Jacuzzi:
- Lift / Elevator:
- Swimming Pool:
- Disabled Facilities:
- DVD/Music Collection:
- Air Conditioning:
- Ensuite Bathroom:
- Balcony:
- Safe:
- Sea View:
- Central Heating:
- City View:
- Daily Cleaning:
Review - Villa Cvita
- Age Group: 1825
- From: United Kingdom
- Traveller type: Sun Seeker
Villa Cvita - Contact the owner
Important Notice : Avoiding Fraud
It's rare, but some helpful hints to watch out for with regards to fraud:
- It is important to NEVER wire funds or use/employ other fund transfer mechanisms such as western union: Always use a credit card to protect yourself against fraud. If owners pressure you into providing a deposit or refuse to accept credit cards, there is a high probability that this is a scam.
- If at all suspicious of fraud, ask to see their website, or any other literature they can provide or send to you. Ask them for contact details for guests who have previously stayed on their property insisting on telephone numbers. Be suspicious of emails that originate from free email services (yahoo, hotmail, gmail, etc)
- Research the property thoroughly on the internet to see if there is any history or mention of scams associated with the property.


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Cars > Andyben's Garage
About Andyben's Garage
About me and my passion for cars
Grew up with Burt Reynolds and Blues Brothers
My first car
Olds Custom Classic
Car I wish I still had
Chrysler PT Chrysler
My dream car
Pontiac Trans Am
Car clubs I'm in
- Type of racing: any
- Driving song: On the Road again
- Car movie: Smokey and the bandit, D.o.H. etc
- Car book: Monstrous Car spotters guide
- Car magazine: Hot Rod,
- Car game: DRIVER SAN FRANSCISCO
— Profile last updated: Apr 15, 2012
Andyben's Garage Comments 1 of 1
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Read comments on Andyben's garage (1)
- Apr 27, 2012 at 10:57 am
- Hey man, add your car
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Cars > Andyben's Garage


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(a) Pursuant to this section, the person in charge of a public place may designate an area for the use of smokers. Notwithstanding the foregoing, a smoking area may not be designated and no person may smoke in any of the following unless the area is enclosed and well ventilated:
(1) Child care facilities.
(2) Hospitals, health care clinics, doctors' offices, physical therapy facilities, and dentists' offices.
(3) Elevators.
(4) Buses, taxicabs, and other means of public conveyance.
(5) Government buildings, except private offices.
(6) Restrooms.
(7) Service lines.
(8) Public areas of aquariums, galleries, libraries, and museums.
(9) Lobbies, hallways, and other common areas in apartment buildings, senior citizen residences, nursing homes, and other multiple-unit residential facilities.
(10) Polling places.
(11) Schools or other school facilities or enclosed school sponsored events for grades K-12.
(12) Retail establishments, excluding restaurants, except areas in retail establishments not open to the public.
(13) Lobbies, hallways, and other common areas in multiple-unit commercial facilities.
(b) If a smoking area is designated, existing physical barriers and ventilation systems shall be used to minimize the toxic effect of smoke, and no more than one-fourth of the total square footage in any public place within a single enclosed area shall be reserved and designated for smokers unless clientele dictates otherwise. No area designated as a smoking area shall contain common facilities which are expected to be used by the public.
(c) Nothing in this section shall be construed to prevent any owner, operator, manager, or other person who controls any establishment or facility from declaring and enforcing a nonsmoking policy in the entire establishment or facility.
(d) Notwithstanding any other provision of this section or this chapter, if any restaurant is deemed by its owner as being too small to have a designated smoking area, it shall be left up to the discretion of the owner if the facility will be a "smoking" or a "nonsmoking" facility.


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RELEASED: Oct. 17, 2005
|Photo by Rick Mickelson, LTS
EAU CLAIRE — A microbiologist at the University of Wisconsin-Eau Claire recently published details of research that may lead to a better understanding of the human immune system, as well as the development of improved antifungal antibiotics to treat the kinds of infections that plague organ transplant recipients, cancer patients receiving chemotherapy and people dealing with immune system disorders such as AIDS.
Dr. Lloyd Turtinen, colleagues and students at UW-Eau Claire have been working for years on research related to understanding how to make antifungal drugs that are both highly effective and less toxic. Prior attempts to decrease the toxicity of these drugs often have led to a corresponding decrease in their effectiveness.
Turtinen and colleagues characterized the expression and release of more than 45 cytokines released from cells exposed to different formulations of Amphotericin B, one of the most commonly used antifungal drugs. Cytokines, first identified in 1974, are small protein molecules involved in the communication between immune system cells and between these cells and cells of other tissue types. Cytokines are actively secreted by these cells in response to external stimuli, such as drug therapy, and can sometimes have effects on the entire body.
When Turtinen and his researchers correlated reported acute side effects in patients treated with the different formulations of Amphotericin B with inflammatory cytokine profiles they generated for each of these formulations, they found that the number of cytokines released by cells were highest in the drug formulations causing acute toxicity in some patients.
"Understanding the innate immune mechanisms and identifying new markers involved in inflammation will help in the development of anti-fungal drugs with better therapeutic indices," said Turtinen.
Two articles detailing these research results were published in the journals Antimicrobial Agents and Chemotherapy, and Immunopharmacology and Immunotoxicology.
For more information, contact Turtinen at (715) 836-3506 or firstname.lastname@example.com.
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Mushroom & hazelnut 'stuff'
Submitted by denzildragon on August 11, 2008 - 11:24pm
Servings:Makes about 2 cups
You can use this mix as a pate, spread, rissoles, burgers or a wrap filling.
Green Burger
Submitted by BmoreRawBoy on June 29, 2008 - 11:33am
Servings:Made 15 burgers, of considerable size
Meaty texture, intense flavor. Satisfying burger with green from celery, jalapenos, zucchini, scallions, pumpkin seeds, and pistachios.
chili-lime fries
Submitted by evergreen on June 24, 2008 - 10:16am
Servings:serves 4 as a side
crunchy fries for your favorite taco or burger
Sizzling Walnut Patties
Submitted by Winona on June 2, 2008 - 9:08am
Servings:Serves 1
Jalapeno adds red-hot flavor to this hefty burger.
broccoli patties
Submitted by LucyP on April 22, 2008 - 1:56pm
Servings:My batch made 10, depends on the size of your veggies.
I fancied a satisfying low fat meal and this is what I came up with.


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Clinical Professor of Emergency MedicineClinical Professor of
Family Medicine
Email: email@example.com
BS, Biology, College of William and Mary MD, Medicine, Eastern Virginia Medical School
Flex Internship, Mary Imogene Basset HospitalFamily Practice, University of IowaMasters of Science in Healthcare Ethics, Creighton University
Advanced Cardiac Life Support CertifiedAdvanced Pediatric Life Support CertifiedAdvanced Trauma Life Support CertifiedMedical License State of IowaMedical License State of New YorkMedical License State of WyomingFamily Practice
Show All
Graber M,
Wilbur J.
Family Practice Examination and Board Review.
3rd edition.
Graber M,
Panko C,
Buresh C.
International Medical Student Rotations: Ethical and Emotional Dilemmas.
Journal of Global Health Perspectives.
2012. Graber M,
Graber A.
Internet Crowdsourcing and Research Ethics-the Case for IRB Review. Journal of Medical Ethics. .
Graber M.
The overlapping roles of the Rural Doctor.
Virtual Mentor (AMA Ethics Journal).
2011. Graber M,
Dachs R,
Darby-Stewart A.
Is telmisartan effective for stroke prevention? .
2009 November 15. 80(10):1042.
Graber M,
Dachs R,
Darby-Stewart A.
Is the San Francisco syncope rule reliable?.
2009 September 15. 80(6):558.
Dachs R,
Graber M,
Darby-Stewart A.
Sample Medications and Overall Prescription Costs.
2009 May 15. 79(10).
Katz D,
Graber M,
Birrer E,
Lounsbury P,
Baldwin A,
Hillis S,
Christensen A.
Health beliefs toward cardiovascular risk reduction in patients admitted to chest pain observation units.
2009 May. 16(5):379-87.
Graber M,
Dachs R,
Darby-Stewart A.
Acyclovir or Steroids as Pharmacologic Treatment of Bell Palsy.
2009 March 15. 79(6).
Graber A,
Graber M.
Wetware, game theory, and the golden rule.
Am J Bioeth.
2008 May. 8(5):30-1.
Date Last Modified: 12/02/2014 -
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text:
BIS Lists to Check
Export Controls & Embargoes
General Overview (130K)
Applying Export Control Regulations to University Research
While export regulations do not apply to most University research efforts, it is essential for faculty to ask questions and contact ORD when one or more of the following apply to their research projects:
Export Administration Regulations (EAR)
EAR, which is enforced by the U.S. Department of Commerce, governs the restriction of items containing a civil and military use (dual-use). Dual-Use Technologies are catalogued in the Commerce Control List (CCL). The complete text of the EAR and CCL are available online - see under "Related Links" on the left column of this page. The CCL has ten specific categories of technologies that are controlled:
International Traffic in Arms Regulations (ITAR)
ITAR governs of items containing a military use and is enforced by the U.S. Department of State. Military-use items are catalogued in the U.S. Munitions Control List (MCL), 22 CFR 121. Complete on-line versions of the ITAR and MCL are available online - see under "Related Links" on the left column of this page - and include items such as:
Export Transactions
Regulations also specify entities and individuals with which transactions are prohibited. Therefore, parties to export transactions must be checked against the most recent lists maintained by the federal government, including:
Access to Export-Controlled Information
Export-controlled information may be disseminated only to U.S. citizens or permanent residents unless a license has been obtained prior to disclosing export-controlled information. Any discussion with a foreign national in the United States, or a person "acting on behalf of a foreign person," constitutes an "export" if it reveals technical information regarding export-controlled technology.
Foreign National
A foreign national is defined as a person who is not a U.S. citizen or permanent resident of the U.S. The term also applies to any foreign corporation, partnership, trust, non-profit organization, or any other organization not incorporated to do business in the U.S., international organizations, foreign governments, or diplomatic entities.
Embargoes - U.S. Department of Treasury, Office of Foreign Assets Control (OFAC)
In addition to export control laws, Universities must also be aware of trade sanctions managed by OFAC. OFAC restrict exports and imports with specific countries through economic sanctions. While the focus of EAR and ITAR is to protect national security by preventing the transfer of certain technologies, OFAC focuses on advancing the foreign policies of the United States. Therefore, restrictions on exports and imports to and from certain countries may apply to a wide range of items, including payment, travel, services, or anything deemed to be of value (review of scholarly work, survey questions).
Penalties for Violations
Penalties for violating U.S. export control laws (EAR, ITAR) or trade sanctions (OFAC) can be severe. The penalty for unlawful export of items or information controlled under the ITAR is up to two years imprisonment, or a fine of $100,000, or both. The penalty for unlawful export of items or information controlled under the EAR is a fine of up to $1,000,000 or five times the value of the exports, whichever is greater; or, for an individual, imprisonment of up to ten years or a fine of up to $250,000 or both.
Export Controls and University Research Fundamental Research Exclusion
Export regulations are not new and have always applied to University research. In the early 1980s the university research community responded to proposed rule changes in order to preserve University values of openness and sharing. There was great concern in the research community that foreign faculty and students not be singled out and prohibited from participating in research activities. This conversation resulted in National Security Decision Directive 189 (NSDD 189), which was issued in 1985.
This directive clarified the definition of fundamental research and stated that fundamental research was NOT subject to the license requirements of export control regulations. It affirmed the long-standing policy of the U.S. government and the Department of Defense not to restrict publication and public presentation of unclassified, federally funded fundamental research results. In effect, under NSDD 189, the only way to restrict dissemination of research results is to classify the project.
Fundamental Research Definition
Fundamental research is defined in NSDD 189 as "basic and applied research in science and engineering in an accredited institution of higher learning in the United States where the resulting information is ordinarily published and shared broadly within the scientific community. Fundamental research is distinguished from proprietary research and from industrial development, design, production, and product utilization, the results of which ordinarily are restricted for proprietary or national security reasons."
The Fundamental Research Exclusion can be lost, however, if a university accepts restrictions on access to or dissemination of information. This includes accepting:
This does not, however, include the reasonable delay of publication for sponsor review in order to protect the disclosure of its own proprietary information, or allow time to file patent application.
Export License
If the fundamental research exclusion is lost and the technology is controlled, a license must be obtained from the cognizant agency (EAR-Commerce Department or ITAR-State Department) before export , including "deemed exports," can occur.
The Fundamental Research Exclusion never applies to the import and export of items restricted by an embargo. As stated earlier, OFAC, the Office of Foreign Asset Control, U.S. Department of Treasury, oversees adherence to these particular trade sanctions. Embargoes may prohibit travel, payment, services, or anything of value to specific countries, individuals, or entities within a country.
While embargoes vary from country to country, six countries have been identified as state sponsors of terrorism and have substantial restrictions on activities. The countries, informally referred to as the T6 countries, include:
Additional countries listed by OFAC as having embargoes include:
In addition to country sanctions, embargoes exist relating to:
Sanctions change quite often, so it is necessary to read actual sanction overviews provided on the OFAC web site.
Eastern Michigan University (EMU) is committed to implementing and maintaining procedures in order to comply with all export control regulations and embargoes.
EMU is committed to disseminating results of its research to the widest possible public audience. It is therefore the practice of the University to accept only research projects that fall within the definition of fundamental research as set forth in NSDD-189. Contractual or program requirements that restrict the use of foreign nationals on grant or contract agreements are inconsistent with the university philosophy of openness of research and non-discrimination. Therefore, such provisions will not generally be accepted.
Export Control Review Committee
The Export Control Review Committee (ECRC) will be established to provide oversight and guidance regarding export control compliance. The committee membership will include one General Counsel representative, two Office of Research Development representatives, one Office of International Students representative, one Business & Finance representative, and two faculty representatives. Members of the committee will be appointed by the Provost and Vice President for Academic Affairs from nominations submitted by heads of the represented units. The Associate Vice President for Graduate Studies & Research or his/her designee will serve as authorized institutional official with authority to secure export licenses when needed.
The committee will review, approve, and monitor technology control plans developed for research that may be export controlled. The committee will also determine when an export license is required or if exception to the law applies. The committee will be responsible for informing all parties of any licensing requirements or prohibitions.
Review Procedures
The Office of Research Development (ORD) will screen all grant and contract proposals and awards for the following:
If one or more of these items apply, the fundamental research exclusion does not apply. Further review by ORD together with the project director is required to determine if the technology is controlled.
It is important to note that export control laws and embargoes apply to all activities undertaken by EMU faculty, staff, and students whether sponsored or not. ORD must be contacted if there are any questions regarding the applicability of export controls or embargoes to non-sponsored research.
If the technology is controlled, a compliance plan must be developed that addresses the following issues:
This plan will be submitted to the ECRC for review and approval, and forwarded to the Project Director, Department Head, and Dean for approval.
Obtaining an Export License
If it is determined that a research topic is a controlled technology, a license may be required before the technology can be shared, disseminated, or exported. This requirement applies to research results as well as tangible items. The processing time for a license is normally four to six months after the application is submitted.
Export Control Compliance Training
The ECRC will be responsible for export control compliance training, informing researchers and administrators about export restrictions and procedures for compliance. A training module will be available on EMU's Responsible Conduct in Research web site.
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The one down side of being in New York for over a week is that I return to find that in two days, the 14th of November is Children In Need night. And anyone who knows me well will know my absolute, total and utter unconditional love for BBC's Children In Need. Over the last few years I've raised thousands of pounds for it, donating my signed personal [&hellip
Last week I was at Houston's ComicPalooza Con, or rather the 'Texas International Comic Con', and it had possibly one of the most awesome beginnings that I've ever had at a convention, and possibly may corrupt any idea in my wife Tracy's mind on what to expect in the future on one of these trips, as on the Thursday before the convention, I [&hellip
I hadn't realised, but as well as my Doctor Who four parter starting at the end of last month, another Doctor Who book of mine has come out – in this case the deluxe hardcover edition of my entire collected first 'season' for IDW, collecting issues #1 to #16 of my Tenth Doctor series, as well as the 2010 annual [&hellip
Sad news today – Tracy and I have had to pull out of attending the ComicPalooza Comic Con in Texas next weekend. It's a 'real world' problem over work conflicts – the chap we rent our flat from is selling it and our 'get out' date has been moved forward from August to the start of June, which means that [&hellip
I knew this was coming out, but I'd been hearing talk of the middle of April. However, today people have been telling me that the new hardcover release of Doctor Who: The Forgotten, with a new cover by original series cover artist Nick Roche and with an extensive afterword by yours truly is already falling through their letterboxes a week [&hellip
Back in 2007, I was invited by IDW to write a six part series for Doctor Who called The Forgotten. To date it has remained my most bought and most printed book, with the paperback trade moving into multiple printings. Well this month, it's returning. Twice. The latter of these is at the end of the month when it's released [&hellip
So. 2012 is finally ending, and the newborn 2013 is already starting to make it's way around the world as I write this, my summary of the year. A year where I began at my lowest ebb and slowly clawed my way back up. Well, that might be a little melodramatic – after all, I wasn't ending the year at the [&hellip


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- Parks (A - Z)
- Addo Elephant National Park
- Agulhas National Park
- Augrabies Falls National Park
- Bontebok National Park
- Camdeboo National Park
- Garden Route (Tsitsikamma, Knysna, Wilderness) National Park
- Golden Gate Highlands National Park
- Karoo National Park
- Kgalagadi Transfrontier Park
- Kruger National Park
- Mapungubwe National Park
- Marakele National Park
- Mokala National Park
- Mountain Zebra National Park
- Namaqua National Park
- Table Mountain National Park
- Tankwa Karoo National Park
- West Coast National Park
- |Ai-|Ais/Richtersveld Transfrontier Park
- Travel
- Reservations
- Conservation
- Wild Card
- Interact
- Contact Us
Honorary Rangers
If you would like to make bookings or view availability for Golden Gate Hotel and Chalets, please click on the 'Make Reservation' button.
You can find more information on the booking process by clicking on 'More Info'.
Public Volunteers in Conservation
The Honorary Rangers as a composite whole, or more frequently in their various regions and national projects organise many participatory events and gatherings around the country.
Some of these are open only to members of the Honorary Rangers while others are open to the public (Public Events) and used to create public environmental awareness, experience the parks or to raise funds for various conservation projects within SANParks.
Those events that are intended for Honorary Rangers participation include:
- The monthly regional or national project meetings (destinations and regular dates differ between the regions/project teams) - contact your local region for details
- Ad hoc project related meetings
- Specified working task group meetings (e.g. coordinated alien invader clearing efforts, game capture, poaching patrols etc.)
- Coordinated learning courses on various environmental topics
- Gatherings of the National Executive Council (NEC)
- Regional Chairman's Meetings (usually once per annum)
- The Corps annual AGM or Indaba


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Along with cleansing autos' interiors and exteriors seven days a week, Hospitality Car Wash & Lube's staffers keep cars healthy and stylish with maintenance and customization services. Ultrasoft lamb's-wool mitts and biodegradable products help hands gently massage away built-up dirt and grime during detailing packages, which range from the exterior-focused express hand wax to the all-inclusive Complete Ultimate detail. Drivers may also roll their rides into Hospitality Car Wash & Lube for a few rounds of standard or synthetic oil or ask a technician to drape their cars' windows with SunTek films that block out ultraviolet rays and thoughts of running a red light.
Before departing on low-riding jaunts, riders must provide a valid motorcycle license and leave a major credit card for a security deposit of up to $5,000. Riders must return cycles with gas tanks filled and emergency parachutes rebundled.
The highly trained technicians at Jiffy Lube tend to about 24 million customers each year with services such as the Signature Service Oil Change package, which promotes the longevity of each vehicle. Staffers acknowledge that oil plays a crucial role in maximizing the lifespan of each car?it cools the motor and prevents moving parts from deteriorating. More than 20,000 technicians who have completed an extensive training program certified by the National Institute Automotive Service Excellence (ASE) nurse vehicles at Jiffy Lube.
In addition to performing oil changes, Jiffy Lube's savants perform air-filtration, electricity, and windshield services, among others. The technicians' quality pledge includes a commitment to transparency, which stipulates that they will inform car owners of any necessary services, only complete a service after it has been approved, and refuse to replace windshields with saran wrap.
Signature service: Tires, wheels, alignments, and accessories
Established: 2012
Reservations/Appointments: Optional
Staff Size: 2?10 people
Average Duration of Services: 30 minutes or less
Brands Used: BFGoodrich, Nitto, Falken, TSW, American Racing
Pro Tip: Free rotations and flat repairs.
What aspect of your job, or the services you offer, most often surprises people?
We service and offer wheels and tires for luxury, tuner, SUV, off-road, and hot-rod vehicles.
Is there anything else you want to add that we didn't cover?
Besides carrying all major brands of tires and wheel lines we also offer many other services for your vehicle. We offer alignments, brakes, lifting, lowering, exhaust systems, cold-air intakes, wheel repairs/machining, and performance upgrades.
No matter how exotic, no car, truck, or SUV is ever turned away at Automotive City, where the technicians offer full-service repairs on all vehicular makes and models. They've provided thorough service since 2010, tuning up cars from moonroofs to tires. When not deftly dealing with complex repairs, techs provide routine-maintenance services, such as oil changes and wheel alignments.
Helping motorists as a test-only smog check facility, Cali Smog gets cars in and out without having to fuss over repairs or study aids. This means shorter waiting times, and a staff of emissions experts that help cars get checked and back on the road. Cali Smog is a State of California-licensed smog check center.


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Tips for mothers with their car keys.
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Never place separate car keys in your pocket. Who remembers each one and how are you going to be aware of any one when you need it ? You will have to use the restroom and in the midst of it all of your automobile keys might eject from your pocket! Car keys are not as easy to replace nowadays as before because of the security systems with the chips. Most new automotive keys have a computer chip that requires a special locksmith pc tool to program it together with your auto's computer. Some of those are a small amount but some are expensive. Get spare car keys before hand and it will definitely save you a lot.
Buying spare car keys reduces the effort if you happen to lose your car keys. Sounds simple ? You'd be surprised how many people don't do it. Dollar stores get me really excited. I actually have lost my car keys multiple times within the dollar store as a result of of seeing some discount. Do you relish yoga or gymnastics? Do you play basketball and leave your garments in an exceedingly far away locker? Have car keys with you? I think you recognize where I'm going with this one. Car keys are an important consideration for athletes that leave valuables in a locker.
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Have a reliable person hold on to a spare set of your car keys. When ordering food for take out try not to place your car keys on the counter at the restaurant. This could be a common sight but you will a lot of times probably forget regarding your car keys again. It is not smart to let kids fake to drive your automobile whereas the secret key is in it. Don't let them know where your spare is. This is dangerous. A heap will happen. Have you looked out side and seen your car driving down the street with your toddler at the wheel ? Your car keys might even get broken not to mention your auto may become the victim of some mishap.
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U.S. Global Investors Reports Results For The Third Quarter Of 2012 Fiscal Year
U.S. Global Investors, Inc. ( NASDAQ: GROW), a boutique registered investment advisory firm specializing in natural resources and emerging markets, recorded net income of $487,138, or 3 cents per share, on revenues of $5.54 million for the third quarter of the 2012 fiscal year. The company's net income increased a modest 19 percent on a quarter-over-quarter basis.
During the third quarter of fiscal year 2011, net income was $2.69 million, or 17 cents per share, on revenues of $11.41 million, based on average assets under management of $3.10 billion.
Average assets under management were $1.97 billion for the quarter ended March 31, 2012, a decrease of 36 percent from the previous year. U.S. Global's assets under management stood at $1.89 billion on March 31, 2012.
"Despite a spectacular first-quarter rally, the investment industry experienced apathy as investors continued to redeem equity mutual funds," says Frank Holmes, U.S. Global Investors CEO.Across the industry, equity mutual funds saw nearly $10 billion redeemed during the first three months of 2012. In 2011, more than $134 billion was redeemed from U.S. equity funds, according to the Investment Company Institute. "While growing the company's assets under management remains challenging in the short term, our reflexive cost structure allows for profitability at a lower asset level. Compared to the same quarter last year, advertising expenses were down 99 percent, employment compensation and benefits decreased nearly 24 percent, and general and administrative costs declined by about 20 percent. In addition, the company owns its headquarters building and carries no debt on its balance sheet," says Holmes. "As U.S. investors were exiting equities, the S&P 500 Index was experiencing its largest first-quarter gain since 1998," says Holmes. "This rise follows government policy changes that allowed money center 'TARP' banks to declare or raise dividend payouts. In fact, at March 31, about 400 companies in the S&P 500 pay dividends now, the largest figure since January 2000."
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First-time writer/director JGL on porn, feminism, and gender
Plenty of eyebrows rose when America's boyfriend, Joseph Gordon-Levitt, announced he was working on a movie about porn addiction. JGL stars in his first outing as writer/director in Don Jon, playing a hyper-sexed, heavily-accented worshipper at the altar of GTL (gym-tan-laundry), with a porn addiction so ingrained that he prefers PornHub over a Snookified ScarJo. (This is the same kid from 3rd Rock from the Sun, teary-eyed Smiths fan who couldn't get over Zooey Deschanel, right?)
"I want to tell a story about how people treat other people more like things," JGL told the Dig. "For me personally, that comes from having grown up as an actor. Actors in our culture often get treated like objects on a shelf. And not just actors; I think we all have a tendency to experience this.
We pigeonhole each other, put each other in boxes with labels, and don't really pay attention to who we're actually talking to."
I thought we were here to talk about porn? Okay, tell me more about this objectification.
"I think the media plays into that. It's something that I've always paid attention to and intrigued me. The [film's] whole opening credit sequence is stuff throughout media: TV shows, movies, commercials, music videos, red carpet, et cetera. All of the above.
I think all of these images serve to teach us that, especially women, are these shiny, pretty things."
When asked if it was a comment on the pornification of culture, Levitt responded "That's one way to put it. I thought it'd be a funny way to get at some of these questions, to have a relationship between a young man who watches too much pornography and a young woman who watches too many romantic Hollywood movies."
But it's alpha male "Don" Jon Martello—not his porn problem—that's the center of the film's attention. "It's definitely a protagonist-structured movie. Even when you're seeing the movies Barbara's (Scarlett Johansson) watching, you see it from Jon's perspective more than from her perspective."
"He's a Don Juan, a classic literary character. He's different than other Don Juan stories in that traditionally, they're tragedies where in the end, the protagonist is destroyed by his shortcomings. I'm more of an optimist, and I like to think that people can change. Even a Don Juan-type of guy can change."
So, the world of Don Jon is soaked in testosterone and bad cologne for a reason. "Both Jon and Barbara are striving very intently towards the dominant norms of what their gender is supposed to be. They're both disappointed.
If you spend all your time and effort trying to fit into a role rather than find what's unique about yourself or your lover or your present situation, you're bound to be disappointed."
Were gender roles an issue for young Gordon-Levitt? "Me personally? No, my mom brought us up instilling in my brother and me the values of the feminist movement. But sure, I've encountered it from people I've known. That's part of day-to-day life. People assume you're this or that, whether it's because of your gender or because of your job or any other number of things. They're always going to try and put you into boxes."
Now the question on everyone's (okay, my) mind: does JGL have a beef against porn?
"I think it depends. I wouldn't make such a sweeping generalization. It depends on what particular medium you're talking about, and the viewer. Esther (Julianne Moore) gives [Jon] a Danish porn film." Was it was modeled after the I Am Curious (Yellow) set of Swedish porn films from the late sixties? "I can't say I've seen those. I had friends who helped us with the title."
A likely story.


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You can tap the collective wisdom of other Microsoft Project users by posing questions in discussion groups, reading Project blogs, or using any of the other community resources mentioned in this article.
For example, you can use discussion groups to access an online group of experienced Project users, including Project Most Valuable Professionals (MVPs), who willingly share their time to answer questions and to provide solutions, tips, and expertise.
Tip Read the Crabby Office Lady's list of tips and tricks to get the most out of the Microsoft Office discussion groups.
Note You need a free Facebook account to join this group.
You can get updates through twitter.com, a third-party tool such as Twitteroo, RSS Feeds, or even your mobile phone.
"I turned to the Project newsgroups five years ago looking for specific information, and I was surprised by the efficiency of the replies I got. Then I found out I could learn even more from troubleshooting other users' issues and answering them, and I ended up being a specialist myself. The newsgroup community has proven to be an invaluable asset in putting me in touch with project managers and others."
— Jan De Messemaeker, Project MVP
Don't have Microsoft Office Project 2007 yet? Download the free Project trial version and discover what you can do with Project.


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A very fresh but slick RSS icon set exclusive to Creative Nerds Readers, the icon set includes a range of various different colours for you to have a play around with. I hope you like the icons, we would love to hear your thoughts and feedback about the icon set.
Licensing Details
The Icon pack made available for free download "Fresh RSS Icons" is licensed under the creative commons license. Which means these icons can be used for personal and/or commercial purposes.
File type: .PNG
Icons in set: 8 Icons
Icon Size: 200x200px


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Adjectives Word Order - Basic
English Grammar Games
This English grammar game is to help you learn the correct Word Order of Adjectives. In this game only two adjectives are used in each example with one of them is a color/colour. The noun is always a toy making this game more interesting for children.
Choose the answer which has the correct word order.
Read our Grammar Rules about Adjective Word Order.
If you found this English grammar game about Adjective Word Order fun, share it with others:


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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"Loved the feel of the matte card, way better than the average paper card or photo card. Was easy to customize. After purchased, received the cards within a week! Will be ordering other cards for our wedding!"
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"We liked this card because we were able to personalize it with the different fonts, and colors for the background. The added picture on the back is a great place to add a personal note to your guests."
"I am extremely happy with the quality of this invitation, it arrived on time, customer service was prompt and everything I ordered arrived - with every detail I requested. Shipping to Australia is pretty pricey, but given the impeccable quality of this product it was worth it to me! Although not something I could afford all of the time."
"Thankyou for providing such a lovely service! We ordered this invite in Stormy Blue with a pearl shimmer - it was a gorgeous Navy and the quality was amazing. We ordered to Australia, and the extra shipping was completely worthwhile - this company was fantastic to work with and our invites arrived very promptly. We will definitely be back for all of our wedding stationary!"


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SMTP Announces Quarterly Cash Dividend Of $0.018 Per Share
CAMBRIDGE, Mass., Feb. 14, 2013 (GLOBE NEWSWIRE) -- SMTP, Inc. (OTCBB:SMTP), a leading provider of cloud-based services to facilitate email deliverability, announces a quarterly cash dividend of $0.018 payable on March 8, 2013 to shareholders of record on February 28, 2013.
During the last quarter of 2012, SMTP made a meaningful investment in digital marketing to increase its online presence, consumer awareness and sales and completed an acquisition of an innovative email testing and analytics business, which was paid for in cash.
"We are very pleased that we were able to make meaningful cash investments in the long-term future of our business, while rewarding our shareholders short-term with significant cash dividends," stated Semyon Dukach, Chairman of SMTP, Inc. "Since our business is stable and growing, and we expect to earn quarterly profits into the foreseeable future, we intend to pay a quarterly dividend on a continuing basis."ABOUT SMTP, Inc. SMTP is a leading provider of cloud-based services to facilitate email deliverability, including bulk and transactional sending, reputation management, compliance auditing, abuse processing and issue resolution. Our services provide customers with the ability to increase the deliverability of email with less time, cost and complexity than handling it themselves. SMTP, Inc. is based in Cambridge, Massachusetts and on the web at http://www.smtp.com . Safe Harbor Statement The information posted in this release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. You can identify these statements by use of the words "may," "will," "should," "plans," "explores," "expects," "anticipates," "continues," "estimates," "projects," "intends," and similar expressions. Forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from those projected or anticipated. These risks and uncertainties include, but are not limited to, general economic and business conditions, effects of continued geopolitical unrest and regional conflicts, competition, changes in technology and methods of marketing, delays in completing new customer offerings, changes in customer order patterns, changes in customer offering mix, continued success in technological advances and delivering technological innovations, delays due to issues with outsourced service providers, and various other factors beyond the Company's control.
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ferent cobest looking Chef jackets different styles and colors for very good prices.
Can't find your city? Try Time Out World for great nights out and all that's going on near you – wherever you are in the world.
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Posted: Thu Oct 18 2012
This family-run uniform emporium hawks professional medical scrubs ($14–$28), catering apparel ($12–$69) and other professional garb from industry-approved brands such as Dickies, Red Kap and Carhartt. Find authentic lab coats ($25), poufy chef hats ($6–$10) and catering tuxedo jackets ($69).
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The Norman Security Suite provides antivirus protection, an intrusion guard, a firewall, parental controls, antispam filters and privacy tools for Windows machines. Norman offers a generous internet security suite license with a year of protection for up to three PCs for one low price. You can also purchase two or three year license packages.
Unfortunately, the software has yet to prove it can protect consistently. The most recent AV-Test scores are quite low. Inconsistent test scores aside, the Norman Security Suite includes a full range of internet protection tools. It also offers a wide selection of configuration options, from hands-off default options to fine tweaking options for advanced users. The homepage provides an easy-to-understand overview of the basics such as the number of items in quarantine, incidences the firewall has blocked, the number of spam emails captured and how many elements the parental controls have blocked. All protection modules include report and log views so you can see the details of what the software has deleted or blocked. This software also has intrusion guard and privacy protection tools to protect your private information from being accessed or accidently shared online. They also have included with the Norman Security Suite an improved ability to run less intrusively and a stronger malware cleaner.
Should you require assistance with your software, you can contact this Norwegian internet security company by telephone or email. However, telephone support is not free; you'll have to pay a per-incident fee for direct telephone support. Free, unassisted support offered online includes FAQs, a PDF user manual, a forum, support articles and a free malware cleaner. You can also follow Norman on Twitter, Facebook, YouTube and LinkedIn.
The most important things to consider in internet security suites is their performance when it comes to preventing and removing infections. Norman Security Suite was not able to perform well enough in tests at AV-Test labs to make it a serious contender. AV-Test labs have a good reputation in the security software industry and they subject products to rigorous tests that establish how well products do at detecting and preventing malware, whether they can remove infections that are already established and whether or not the products falsely flag safe files as malicious. With so many competitors turning in better performance scores, the advantage to purchasing the Norman Security Suite is not obvious to us.
One Norman license can protect up to three computers.
Norman test results are insufficient to make them a contender.
Given Norman's performance at AV-Test labs, it is not the very best product for protecting PCs from malware.