text:
Don't Have an Account? Join the IHG® Rewards Club
Redeem when you want, for what you want. Your points never expire and there are no blackout dates.
Reward Nights
When redeeming points for a Reward Night, you may only book one room at a time.
Once you complete your Reward Night reservation you will be given the option to duplicate this reservation.
* Requires affiliation in the respective organization.
** Best Available Rate Search does not include affiliation rates.
To book more than 9 rooms for one stay or request a quote, please use our Easy Meetings tool or call 1-800-MEETING (in United States, Mexico and Canada).
Situated in the suburbs of North Austin, the Candlewood Suites® Austin Arboretum - Northwest hotel offers the most comfortable accommodations for your extended visit to Texas. Whether you're here for business or pleasure, you can have a carefree stay as our hotel's guest.
In North Austin, the hotel is surrounded by major employers, such as IBM, Motorola, Freescale & Microsoft. We've got free Wi-Fi and wired
View More
In North Austin, the hotel is surrounded by major employers, such as IBM, Motorola, Freescale & Microsoft. We've got free Wi-Fi and wired access throughout the hotel, so you can connect to home and the office. For your extended stay, our hotel's suites in Austin, Texas help you stay productive with amenities like an executive desk & two separate phone lines.
You can enjoy the convenience of nearby shopping and dining when you choose our hotel's location in north Austin. We're within blocks of Arboretum Mall, The Domain & Arbor Walk Shopping Center. Check out Austin's famous live music venues on 6th Street in downtown Austin. If you're looking for outdoor fun, beautiful Lake Travis is a short 15-mile drive.
When looking for extended stay hotels in Austin, Texas, remember we've got some of the best amenities around. Work off stress in the 24-hour Fitness Center, or relax in the evening with a movie from the complimentary DVD library. In the Candlewood Cupboard, you can purchase meals, snacks, & sundry items at value prices. Call today to enjoy our well-appointed extended stay accommodations in Austin, Texas!
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A & P supermarket
|Click here to view the item (new window)
|Black-and-white photographs
|A & P supermarket
|A & P Supermarket, 1950s. Photograph taken in the 1950s of the A & P which was one of the first supermarkets to locate in Gainesville. The A & P was located on 331 West Washington Street and the corner of Grove Street. By 1974, it had relocated to a shopping center.
Caption: "Hall County Library Photo Collection (0629) Gainesville, Georgia."
Digitized by: Digital Techniques, Inc.
Electronic version made available through a federal Library Services and Technology Act Grant and Georgia Public Library Services.
|Great Atlantic & Pacific Tea Company | Supermarkets--Georgia--Gainesville | Chain Stores--Georgia--Gainesville | Grocery trade--Georgia--Gainesville | Hall County (Ga.) | Gainesville (Ga.)
|Hall County Library System (Ga.)
|Online Publisher:
|[Gainesville, Ga. : Hall County Library System], 2001
|Original Material:
|1 photograph : b&w ; 23 x 18 cm. | Forms part of: Hall County, Georgia historical photograph collection.
|Rights and Usage:
|Cite as: [Name of photograph], Hall County, Georgia historical photograph collection, Hall County Library System.
|Persistent Link to Item:
|Related Institutions:
|Hall County Library System (Ga.)
|Collection Information:
|Hall County Georgia Historical Photograph Collection

subset: commoncrawl


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Just thought I'd send a picture of the beautiful rainbow during the storm tonight just outside of Leonardsville
Bright Spot in the storm
By: djakub517Subscribe Channel: News Location: Leonardsville NY
+ Comment!
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Speed up your app with Method Cacheable
Method Cacheable allows you to cache any Ruby method easily in memcache. It makes calls to the cache in your code explicit so you know whats going on at all times.
nice information.. thanks for sharing it...
ruby rails developeropenwave - April 20, 2012 14:01


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Eine und Kleine - Chapter One
Use your arrows to move Eine and Kleine through the game. Collect every gold star you can as you need a minimum number of them on each level to get to the next. When you're ready for a fun adventure, you'll have an incredible time playing Eine und Kleine - Chapter One!


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- About DSU
Akiah S. Powell (left), a senior political science major who passed away on Feb. 4, was close friends with Samantha Holsey, also a DSU senior political science major.
DSU Mourns the Loss of Honors Student Akiah S. Powell
Posted: February 12, 2012
The DSU community is mourning the loss of Akiah S. Powell, a senior political science major who passed away unexpectedly on Feb. 4 due to natural causes.
The death of Ms. Powell was made all the more poignant by her projected graduation this upcoming May and her plans to enter law school immediately afterward.
Formerly of the Bronx, N.Y., her family had moved to Bushkill, Pa., about five years ago, according to her mother, Marilyn Powell. By all accounts, Akiah was a dedicated student who was known to be service oriented, a faithful friend and destined for success. She was on the Dean's List throughout her entire academic journey at DSU.
Akiah S. Powell would have graduated in May and expected to enrolled in law school in the fall.
A political science major with a minor in pre-law, Ms. Powell had already taken the Law School Admissions Test (LSAT) and applied to a number of law schools. "When it came to legal studies, I believe that Akiah found her niche and a path to a successful career," said Dr. Sam Hoff, the director of the DSU Law Studies Program. "She had demonstrated the requisite skills to become an attorney and she was on the precipice of being accepted to law school."
Dr. Hoff noted that Akiah possessed strong opinions about certain cases he taught in her Constitutional Law and Civil Liberties class.
"She had a sort of righteous indignation about injustices that cannot be taught," Dr. Hoff said. "It is a trait that made me confident that she would have been a stellar attorney and would have contributed significantly to the legal profession."
Akiah had been a McNair Research Scholar since the spring of 2011 and within that program had demonstrated a passion for education and her love for fellow students, according to Tonia P. Conley, director of the DSU McNair Program. Ms. Conley said upon becoming a McNair Scholar, Akiah quickly bonded with her peers in the program and demonstrated her leadership and innate strengths among them.
"We could always depend on the warmth of her personality and the beauty of her smile," Ms. Conley said. "Akiah epitomized our program's slogan: 'Pursuing Excellence Without Excuse.' She was certainly more than a student… she was a scholar!"
She said as a McNair scholar, Akiah had conducted research with Dr. Hoff (also a professor of political science) on a project entitled "The Continuing Impact of Religion on Public Policy," and was to have presented that paper at a research event in Nashville, Tenn., in March 2012.
Dr. Akwasi Osei, chair of the Department of History, Political Science and Philosophy, as well as another advisor of Ms. Powell, said that she was a grounded and focused student who always had a smile and was eager to help.
"She had a quiet strength," Dr. Osei said. "She was strong in a quiet way and she made her presence felt quietly."
During Akiah's undergraduate journey, she distinguished herself as an inductee of both the Pi Sigma Alpha National Political Science Honor Society/Upsilon Chapter, as well as the Pi Gamma Mu International Social Science Honor Society/Delaware Alpha Chapter. She was a co-recipient of her academic department's 2011 George Washington Leadership Award, a Thurgood Marshall scholar, and was a member of the DSU Honors Program. She had been selected to be an alternative legislative fellow at the Delaware General Assembly.
Ms. Powell also worked in the Division of Academic Enrichment as a supplemental instruction leader and Writing Lab specialist/tutor during the 2011-2012 school year. According to Kenneth Hunt, a supplemental instruction coordinator, Akiah showed exceptional knowledge in the field of English; and as an English SI Leader and writing lab specialist, she demonstrated outstanding leadership and dedication to each student.
"In addition to the students gaining a strong sense of confidence, the overall class average increased as a result of her method of teaching," Mr. Hunt said. "She gracefully served both positions within the division with honor and distinction."
Akiah S. Powell (2nd from the right) enjoys a fellowship moment with some friends.
Jean H. Gilroy, academic support coordinator, added that "Akiah was a role model to all the students with whom she worked. Many lives have been touched, and many students will succeed and graduate from DSU due to her efforts."
Among her student peers she was good friend and someone who could always be counted on to be helpful.
Samantha Holsey, also a senior political science major, has been a close friend of Akiah ever since their freshman year when they shared an honors suite in Wynder Towers. Ms. Holsey described her good friend as "very genuine and independent" and as being one who was interested in others' success as well as her own.
"Instead of trampling over you to get to first-place, she would bring you with her," Ms. Holsey said.
Akiah Shekira Powell was born to Hillary (Piper) and Marilyn Powell on March 12, 1990, in Bronx, N.Y. Akiah loved the Lord and was a member of the Smyrna Seventh-Day Adventist Church located in the Bronx. She attended the R. T. Hudson Elementary School and graduated from Northeastern Academy in New York City. She began her academic career at DSU in August 2008.
Akiah S. Powell
The following is an excerpt of a personal statement that Akiah wrote concerning her motivations and goals for her life:
"One of my favorite quotes by Aristotle says, "We are what we repeatedly do. Excellence then, is not an act, but a habit." This quote inspires and motivates me throughout my educational journey and helps to remove the negative connotation and assertion by some that people are the product of their environment. Rather, I am committed to ongoing studies, research, improving myself, and sharing and encouraging others to do the same; by doing so, I hope to impact not only my community but that of others." – Akiah S. Powell
Funeral services will be held on Sunday, Feb. 12, with a viewing from 3-5 p.m. and a homegoing service immediately afterward at 5 p.m. at Ephesus Seventh Day Adventist Church, 101 W. 123rd St., in the Harlem in New York City. The burial will take place the following day, Monday, Feb. 13) at 10 a.m. at the George Washington Cemetery, Paramus, N.J.


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Whether you are looking to celebrate a family event, wedding rehearsal, baby or bridal shower, birthday, anniversary, a corporate meeting or event, or need a special place to celebrate the holidays, Cascone's & Johnny Cascone's provide unique spaces that are conducive for any event. With a reputation for outstanding food, hospitality & service the Cascone family is prepared to provide outstanding private dining or meeting opportunities for you and your guests. Please call or email for quotes from either of our restaurants below.
Johnny Cascone's Italian Restaurant
6863 W. 91st St
Overland Park, KS
Cascone's Italian Restaurant
3733 North Oak Trafficway
Kansas City, Missouri
Site Design by: Creative Impressions
All rights reserved. Copyright Cascones Family Restaurant 2011
Receive valuable coupons for dinners and up to date information on our restaurants by joining our Email List
for Cascones North
for Jonny Cascones
Italian Restaurants
60 Years


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Chicken Curry with Veggies on Whole-Grain Couscous
Epicurious | May 2007
Makes 2 servings
This tasty curry goes wonderfully on top of couscous and makes for a filling meal.
Ingredientsadd to shopping list
- 2 tablespoons extra-virgin olive oil
- 1/2 onion, chopped
- 1 tablespoon peeled and chopped ginger
- 1 garlic clove, minced
- 1 tablespoon turmeric
- 1 tablespoon curry powder
- 1 tablespoon brown sugar
- 2 (5- to 6-ounce) skinless, boneless chicken breasts, sliced into 1-inch pieces
- 1 floret broccoli, chopped
- 1 small floret of cauliflower, chopped
- 1 carrot, chopped
- 1 cup whole-grain couscous, prepared according to instructions on the box
1. Combine the oil, onion, ginger, garlic, turmeric, curry powder, and brown sugar in a large skillet and cook over medium heat until onions turn clear and smell sweet, about 5 minutes.
2. Add the sliced chicken breasts and cook until the meat is done, about 57 minutes.
3. Add 1 cup of water along with the broccoli, cauliflower, and carrot. Cook for about 15 minutes, or until the vegetables are tender. Add water as needed to maintain a saucy consistency.
4. Serve over hot, freshly cooked couscous.
Reprinted with permission from Bikini Bootcamp: Two Weeks to Your Ultimate Beach Body, © 2007, by Melissa Perlman and Erica Gragg, Broadway Books
my notes
Nutrition Informationper serving (2 servings) POWERED BY Edamam
- Calories856
- Carbohydrates98 g (33%)
- Fat30 g (46%)
- Protein50 g (100%)
- Saturated Fat6 g (32%)
- Sodium200 mg (8%)
- Polyunsaturated Fat5 g
- Fiber12 g (50%)
- Monounsaturated Fat16 g
- Cholesterol100 mg (33%)
recipe featured in
recipe at a glance
type: Quick & Easy
main ingredients: Broccoli, Chicken, Vegetable, Cauliflower, Couscous, Curry, Ginger
cuisine: Indian


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Not much of our software currently requires activation over the net, as long as its as automated as possible I don't normally mind(if we could add the details to the msi that'd be great).
It must support automatic proxy detection and authentication - I've found a few programs that don't, having to resort to email/phone or other manual forms of activation isn't fun if it needs doing for a decent amount of workstations
Make sure the activation carries accross between users - I've encountered one program that required activation per user and pc, this is the only software I've so far refused to install - fourtunatly the company has since fixed this issue.
Oh and if your going to ask for things like address, phone number that need to be entered per workstation please keep it short... software that asks for loads of info other than the serial/email address tends to get false info returned.


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A Concept on the Rise
If you're an entrepreneur looking into becoming a franchise business owner for the first time, or adding a new concept to your growing portfolio of proven businesses, you're savvy enough to demand the following:
- An industry that is growing
- Within that industry, a segment that's thriving
- Within that segment, a concept with the goods to be a leader
We get it. And we've got it. So do the experts. In fact, Franchise Business Review named Einstein Bros.® as one of the Top 50 Franchisee Satisfaction Award Winners.
And at Einstein Bros.®, we're focused on developing markets that capture and/or enhance efficiencies in marketing, advertising and operations oversight. In addition, we seek those markets that meet with our demographic and psychographic customer profiles.


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Milwaukee Electric Tool 6390-21 - Tilt-Lok™ 7-1/4 in. Circular Saw with Case
The Tilt-Lok™ handle on Milwaukee's 6390-20 is the most revolutionary concept for circular saws in years. The eight position cushioned top handle adjusts to any cutting application maximizing comfort and control. Weighing in at 10.4 pounds and delivering 3.25 maximum horsepower, this tool offers the best power to weight ratio in the industry. The blade can bevel to 50 degrees and offers superior visibility and a clear sight line from either side. Helical steel gears and a 22 amp switch are just two of the features that ensure the Milwaukee's reputation for durability.
We are currently offering FREE SHIPPING on Milwaukee orders over $150!
Circular Saw Blade, Hex Blade Wrench 48-55-9166 Carrying Case
Burns Tools
Contact & Directions


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Things to do Wednesday: 11.07.12
CORPUS CHRISTI - Diabetes classes
Coastal Bend Health Education Center will host diabetes education classes from 9 a.m. to 4 p.m. Wednesdays and 6 to 8 p.m. Thursdays in November at Del Mar College West, 4101 Old Brownsville Road, Health Sciences 1 Building, Room 262. Cost: $25. Information: 825-2804.
Stress seminar
Dr. Nestor Praderio will present strategies for avoiding and relieving stress during the holiday season from 6 to 7 p.m. at Mirador, 5857 Timbergate Drive. Praderio is the medical director of the Behavioral Medicine Department and director of the Geropsychiatric Unit at Christus Spohn Hospital. Free. Information: 236-4281.
Editor's note: An earlier version of this item incorrectly listed the cost for diabetes education classes hosted by the Coastal Bend Health Education Center each Wednesday and Thursday in November. The classes are $25.


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See, I always picked you to be 21-25ish. Definitely not as young as 17 but you're still older than I expected. :O
Also, I must confess to being... somewhat of a keyboard turner but this is entirely because my set-up is funky and I got myself used to raiding Ulduar on a laptop and not always having a mouse, and well, touchpad turning is far far worse than keyboard turning. Being very left-handed, I can't use a mouse with my right hand, and as a result, I can't comfortably used wasd to move, so have my numpad set up for movement (8456 for up/left/back/right, 79 for strafe left/right) but still use my mouse for most things. The only problem I have with using my mouse is the inability to backpedal when I need to.
Also, an ingame example of keyboard turning vs mouse turning would've been more helpful :P


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Ariel Pink's Haunted Graffiti
Mature Themes
Despite the title, Ariel Pink's new album revels in its juvenile impulses. It's filled with choruses of "Who sank my battleship?", references to video games, and odes to schnitzel, nymphos, and "yummy pink slime." Mature Themes is more defiantly quirky than 2010's remarkable Before Today, but it's also less successful. The ebullient "Only In My Dreams" and affecting "Farewell American Primitive" are among the best things he has recorded, but this batch of hazily produced, keyboard-driven songs are frequently hit-or-miss. It's never a good sign when an obscure cover—Emerson's "Baby," a slinky and soulful duet with DamFunk—proves to be the album's highlight. Ariel Pink has been rightfully touted for his ability to seamlessly blend shards of '80s pop music into eccentric songs that sound naggingly familiar, but here his combination of sophisticated arrangements and sarcastic humor evokes Frank Zappa's early recordings more than anything else.
—Jeff Jackson
Black Moth Super Rainbow
Cobra Juicy
(Rad Cult)
I want to set my iPod to wake me up to this album. "Black Moth Super Rainbow" is less a random collection of words, more an accurate description of the impression the music leaves you with. Cobra Juicy is the band's fifth album, coming after a three-year hiatus. The tracks spin around, lighting up in Technicolor electric sound. There is darkness, too, an edge that shows up in beats and in raspy lyrics. On "Psychic Love Damage" you can't understand the words, but it really doesn't matter—the occasional coherent word enhances the feeling of fuzzy disorientation that the rest of the music creates. Cobra Juicy feels and sounds like the best kind of bad decision—it's partially nostalgic, partially trippy, and fully seductive.It pulls from the '70 and '80s, but stays true to its times.
—Kathleen Broadhurst
Pilot Machines
(Planetary Group)
Combining watery pop progressions with clever melodies, state-of-the-art looping techniques and strange, somewhat otherworldly lyrics, this recording delivers rich, thought-out music that's in no hurry to go in any particular direction. There are ballad-ish numbers, dancy rockers and wandering odes often embellished with the band's trademark string arrangements. The common thread seems to be a progressive, trance-y element that recalls mid-career Yes or Peter Gabriel albums, replete with hypnotic arpeggios achieved via plucked violin strings, loopy 12-string guitar Fripperies and Bela Fleck-flavored banjo parts, with a very skilled, high tenor voice weaving a distant but beckoning elvish cantrip through the music's stratosphere. Complex vocal harmonies are equally impressive on this effort, and the production (by local-ish rock royalty Nathaniel Kunkel) is simply outstanding. "When Fortune Comes," while not likely to be a "hit single," is a moving, exceptional song in every aspect.
—Tom Sturm


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The Driver with Wolf Wigo
Quantity in Basket:none
"In The Driver, Wolf Wigo shows why he is one of the best players in the world and he does a great job
of sharing his secrets. This video is not only a great educational tool for coaches and players - from
novice to the international level, but its also highly entertaining. If you are serious about water polo,
you need to buy this tape."
Dante Dettamanti, former coach at Stanford.DVD PREVIEW:


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Hardware news tagged Sharp
Monday, December 24, 2012
Sharp Demonstrates 6" Screen with 2560*1600 Resolution, Opens Doors to Extreme High-Definition Displays.
Sharp: IGZO Display Panels to Revolutionize Resolutions and Pixel Density of Displays
Tuesday, December 4, 2012
Sharp Set to Sell TV Factories to Foxconn for $667 Million – Report.
Sharp to Sell Overseas TV Assembly Plants to Foxconn to Get Cash
Qualcomm Confirms Investment into Sharp
Monday, December 3, 2012
Qualcomm May Become Largest Shareholder of Sharp.
Qualcomm and Sharp Could Jointly Develop Displays
Wednesday, November 28, 2012
Sharp to Introduce 4K Professional Display with IGZO Panel.
Sharp Set to Release 4K IGZO Display for Japanese Market
Tuesday, November 13, 2012
Intel and Qualcomm May Team Up for Sharp Investment.
Intel and Qualcomm In Talks to Invest $378 Million into Sharp
Tuesday, October 2, 2012
Sharp Initiates Production of 5" Full-HD Screens.
Sharp Pixel Density Record with 5"/1080p Display
Monday, October 1, 2012
Sharp Produces Adequate Volumes of iPhone 5 Screens - Company.
Sharp Insists in Adequate Production of Apple iPhone 5 Screens
Thursday, September 6, 2012
Apple Cuts Orders on Samsung's Components for iPhone 5 - Reports.
Apple to Reduce Orders from Samsung to Diversify Supply Chain
Wednesday, August 15, 2012
Foxconn Plans to Build $10 Billion Manufacturing Facilities in Indonesia - Report.
Hon Hai to Build Additional Factories in Indonesia to Boost Output of Smartphones, Tablets and TVs
Wednesday, August 1, 2012
Sharp to Start Shipping Screens for New Apple iPhone This Month.
Sharp Confirms Manufacturing of Screens for Apple iPhone 5
Monday, July 30, 2012
Price and Screen Sizes to Restrict OLED TVs to Less Than 1% of Market Through 2013 - Analysts.
OLED TVs Will Not Become Popular in Coming Years Due to Prices, Screen Sizes
Thursday, June 21, 2012
Panasonic and Sony to Team Up for OLED TVs Next Week - Reports.
Panasonic and Sony to Announce Joint Plans for OLED TVs Next Week


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Quotes & Info
|RGDX > SEC Filings for RGDX > Form 10-Q on 14-Nov-2013
|All Recent SEC Filings
Quarterly Report
Special Note Regarding Forward-Looking Statements
Certain information included or incorporated by reference in this Quarterly Report on Form 10-Q for the period ended on September 30, 2013 contains or may contain forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, as may be amended from time to time. Statements that are not historical facts, including statements that use terms such as "anticipate," "believe," "should," "expect," "intend," "plan," "project," "seek" and "will" and that relate to our plans, objectives, strategy and intentions for future operations, future financial position, future revenues, projected costs and prospects are forward-looking statements but not all forward-looking statements contain these identifying words. Forward-looking statements relate to future periods and may, for example, include statements about our expectation that, for the foreseeable future, a significant amount of our revenues will be derived from ResponseDXź product sales; our ability to maintain revenue from pharmaceutical clients; the factors that may impact our financial results; the extent of our net losses and our ability to achieve sustained profitability; our business strategy and our ability to achieve our strategic goals; our expectations regarding revenues from ResponseDXź products; the amount of future revenues that we may derive from Medicare patients; the potential or intent to enter into distribution arrangements; our ability to sustain or increase demand for our tests; our sales forces' capacity to sell our tests; plans for the development of additional tests; our expectation that our research and development, general and administrative and sales and marketing expenses will increase and our anticipated uses of those funds; our ability to comply with the requirements of a public company; our ability to attract and retain qualified employees; our compliance with federal and state regulatory requirements; the potential impact resulting from the regulation of our tests by the U.S. Food and Drug Administration; the impact of new or changing policies or regulation of our business; our belief that we have filed adequate patent and trademark applications to protect our intellectual property rights; the impact of accounting pronouncements and our accounting policies, estimates, assumptions or models on our financial results; and anticipated challenges to our business.
Forward-looking statements are subject to significant inherent risks and uncertainties that could cause actual results to differ materially from those expected. For us, these risks and uncertainties include, but are not limited to, our ability to develop and commercialize new product without unanticipated delay; the risk that we may not maintain reimbursement for our existing tests or any future tests; the risk that reimbursement pricing may change; the risks and uncertainties associated with the regulation of our tests; our ability to compete; our ability to obtain capital when needed; and our history of operating losses. In light of the risks and uncertainties inherent in all forward-looking statements, including the above, the inclusion of such statements in this Quarterly Report on Form 10-Q for the period ended on September 30, 2013 should not be considered as a representation by us that our objectives, projections or plans will be achieved. These statements are based on current plans, estimates and expectations. Actual results may differ materially from those projected in such forward-looking statements and therefore you should not place undue reliance on them. The forward-looking statements included in this Quarterly Report on Form 10-Q for the period ended on September 30, 2013 speak only as of the date hereof and we expressly disclaim any obligation or undertaking to publicly update any forward-looking statements contained herein to reflect any change in our expectations with regard thereto or any change in events, conditions or circumstances on which any such statement is based.
The following discussion of our financial condition and results of operations should be read in conjunction with our unaudited financial statements and related notes to the financial statements included elsewhere in this Quarterly Report on Form 10-Q for the period ended September 30, 2013 and our audited financial statements for the year ended December 31, 2012 included in our Annual Report on Form 10-K for the period ended December 31, 2012 previously filed with the Securities and Exchange Commission.
Response Genetics, Inc. (the "Company") was incorporated in the State of Delaware on September 23, 1999 as Bio Type, Inc. for the purpose of providing molecular profiling services of tumor tissue that has been formalin-fixed and embedded in paraffin. In August 2000, we changed our name to Response Genetics, Inc.
Our Approach
Clinical studies have shown that not all cancer chemotherapy works effectively in every patient, and that a number of patients receive therapy that has no benefit to them and may potentially even be harmful. Our goal is to provide cancer patients and their physicians with a means to make informed, individualized treatment decisions based on genetic analysis of tumor tissues. We are focusing our efforts in the following areas:
Ć Continued commercialization of our ResponseDXź tests;
Ć Developing additional diagnostic tests for assessing the risk of cancer recurrence, prediction to therapy response and tumor classification in cancer patients; and
Ć Expanding our testing services business by pursuing new technologies through collaborations and in-licensing to expand our business.
Our technologies enable us to reliably and consistently extract the nucleic acids ribonucleic acid ("RNA") and deoxyribonucleic acid ("DNA") from tumor specimens that are stored as formalin-fixed and paraffin-embedded, specimens and thereby to analyze genetic information contained in these tissues. This is significant because the majority of patients diagnosed with cancer have a tumor biopsy sample stored in paraffin, while only a small percentage of patients' tumor specimens are frozen. Our technologies also enable us to use the formalin-fixed paraffin embedded ("FFPE") patient biopsies for the development of diagnostic tests.
The outcome of cancer therapy is highly variable due to genetic differences among patients. Some patients respond well with tumor shrinkage and increase in life span. Other patients do not obtain benefit from the same therapy and may actually experience toxic side effects, psychological trauma and delay in effective treatment.
At present, most cancer treatment regimens are administered without any pre-selection of patients on the basis of their particular genetics. However, recent development of very sensitive molecular technologies has enabled researchers to identify and measure genetic and biochemical factors in patients' tissues that may predict the probability of success or failure of many currently used anti-cancer agents. In order to increase the chances of a better outcome for cancer patients, we have and continue to expand our development of genetic tests for measuring predictive factors for tumor response in tumor tissue samples. We offer tests for non-small cell lung cancer ("NSCLC"), colorectal cancer ("CRC") and gastric and gastroesophageal cancer ("GE"), and melanoma cancer patients' tumor tissue specimens through our ResponseDX: Lungź, ResponseDX: Colonź, ResponseDX: Gastricź and ResponseDX: Melanomaź test suites at our laboratory located in Los Angeles, California, which is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA"). These tests serve to help oncologists make optimal therapeutic decisions for cancer patients. The results from our tests may help oncologists choose among therapies to treat their cancer patients. As of September 30, 2013, our sales team consisted of 23 members located in the West Coast, Midwest, and East Coast areas of the United States.
Diagnostic Tests for Other Cancers
In August 2013, the Company acquired substantially all of the assets of Pathwork Diagnostics, Inc. including its FDA-cleared Tissue of Origin cancer test. The acquired Tissue of Origin test uses a proprietary microarray platform and proprietary software to compare the expression of 2,000 genes in a patient's tumor with a panel of 15 known tumor types that represent 90% of all cancers. The test received FDA clearance in June 2010.
In addition to ResponseDX: Lungź, ResponseDX: Colonź, ResponseDX: Gastricź, ResponseDX: Melanomaź, and the newly acquired Pathwork Tissue of Origin test that we will offer as ResponseDx: TOOTM, we intend to develop and commercialize tests for other types of cancer. In the third quarter of 2013, we added four new tests: MET by FISH, cKit mutation by sequencing, UGT1A1 by sequencing and HER2 mutation by sequencing. We also are identifying genetic profiles of tumors that are more or less responsive to a particular therapy. Following the development of tests to determine the most active therapy regimen for the individual patient at risk, we intend to leverage our relationships in the healthcare industry to market, sell or license these tests as a means for physicians to determine the courses of cancer treatment.
Pursue Additional Collaborations and In-licensing to Expand Our Business
We intend to pursue additional collaborations and services with pharmaceutical companies or in-licensing of products or technologies that will enable us to accelerate the implementation of our plans to expand the services we provide to oncologists and pathologists. We expect to implement this plan by way of licensing of technology and know-how, investments in other companies, strategic collaborations, and other similar transactions. We expect these collaborations to provide us with early access to new technologies available for commercialization.
There are no assurances that we will be able to continue making our current ResponseDXź tests available, or make additional ResponseDXź tests available; or that we will be able to develop and commercialize tests of other types of cancer; or that we will be able to expand our testing service business through collaborations.
We anticipate that, over the next 12 months, a substantial portion of our capital resources and efforts will be focused on sales and marketing activities related to our ResponseDXź diagnostic tests, research and development to expand our series of diagnostic tests for cancer patients, and for other general corporate purposes.
Research and development expenses represented 10.5% and 9.6% of our total operating expenses for the three months ended September 30, 2012 and 2013, respectively, and 13.6% and 9.6% of our total operating expenses for the nine months ended September 30, 2012 and 2013, respectively. Major components of the $426,105 and $391,592 in research and development expenses for the three months ended September 30, 2012 and 2013, respectively, and of the $1,695,851 and $1,136,478 in research and development expenses for the nine months ended September 30, 2012 and 2013, respectively, included supplies and reagents for our research activities, personnel costs, occupancy costs, equipment warranties and service, patent fees, insurance, business consulting and sample procurement costs.
Critical Accounting Policies and Significant Judgments and Estimates
This discussion and analysis of our financial condition and results of operations is based on our consolidated financial statements, which have been prepared in accordance with U.S. generally accepted accounting principles ("U.S. GAAP"). The preparation of these financial statements requires management to make estimates and judgments that affect the reported amounts of assets, liabilities and expenses and the disclosure of contingent assets and liabilities at the date of the financial statements, as well as revenues and expenses during the reporting periods. We evaluate our estimates and judgments on an ongoing basis. We base our estimates on historical experience and on various other factors we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results could therefore differ materially from those estimates under different assumptions or conditions. We believe the following critical accounting policies reflect our more significant estimates and assumptions used in the preparation of our financial statements.
Revenue Recognition
Pharmaceutical Revenue
Revenues that are derived from pharmacogenomic testing services provided to
pharmaceutical companies are recognized on a contract specific basis pursuant to
the terms of the related agreements. Revenue is recognized in accordance with
ASC 605, Revenue Recognition, which requires that four basic criteria must be
met before revenue can be recognized: (1) persuasive evidence of an arrangement
exists; (2) delivery has occurred and title and the risks and rewards of
ownership have been transferred to the client or services have been rendered;
(3) the price is fixed or determinable; and (4) collectability is reasonably assured.
Revenues are recorded on an accrual basis as the contractual obligations are completed and as a set of assays is processed through the Company's laboratory under a specified contractual protocol and are recorded on the date the tests are completed. Certain contracts have minimum assay requirements that, if not met, result in payments that are due upon the completion of the designated period. In these cases, revenues are recognized when the end of the specified contract period is reached.
In March 2010, the Company entered into a non-exclusive license agreement with GlaxoSmithKline, LLC, which calls for payments to be made to the Company when certain events specified in the agreement occur, specifically GlaxoSmithKline, LLC submitting an application to use the license to the FDA, the FDA approving the application, and issuance of certain patent applications to the Company. The Company has no further obligations related to these events and therefore records the amount due into revenue at the time the event occurs. The Company incurs no additional cost related to these revenues at the time these events occur.
ResponseDX ź Revenue
Net revenue for the Company's diagnostic services is recognized on an accrual basis at the time discreet diagnostic tests are completed. Each test performed relates to a specimen encounter derived from a patient, and received by the Company on a specific date (such encounter is commonly referred to as an "accession"). The Company's services are billed to various payors, including Medicare, private health insurance companies, healthcare institutions, and patients. The Company reports net revenue from contracted payors, including certain private health insurance companies, and healthcare institutions based on the contracted rate, or in certain instances, the Company's estimate of the amount expected to be collected for the services provided. For billing to Medicare, the Company uses the published fee schedules, net of standard discounts (commonly referred to as "contractual allowances"). The Company reports net revenue from non-contracted payors, including certain private health insurance companies, based on the amount expected to be collected for the services provided. The Company analyzes historical payments from payors as a percentage of amounts billed by the Company to estimate expected collections for purposes of recording net revenue.
The Company has its Medicare provider number which allows it to invoice and collect from Medicare. Invoicing to Medicare is primarily based on amounts allowed by Medicare for the service provided as defined by Common Procedural Terminology ("CPT") codes. In January 2013, the initial 2013 annual Medicare fee schedule update was announced which included proposed changes to Medicare reimbursement rates that significantly reduced the reimbursement rates for certain of the testing services we provide. The Company participated with other impacted organizations to provide guidance to the local Medicare Administrative Contractor ("MAC") that may result in adjustments to the proposed reimbursement rates to better reflect the value of the services being performed. As a result of this guidance, the local MAC updated certain pricing through September 2013 which reflected an increase in many of the tests originally priced in January 2013. On October 1, 2013, the Centers for Medicare and Medicaid Services ("CMS") issued fees for some, but not all, of the CPT codes used by the Company. It is uncertain if continued guidance provided to Medicare and the local MAC by impacted organizations will result in additional fee increases during 2013. If, however, the current level of reduction in reimbursement rates is adopted as is, it may have a material adverse effect on the Company's operations.
As a result of these CPT code changes and Medicare price changes, we have experienced a departure from our normal reimbursement patterns with Medicare and other payors. Specifically, we have experienced delays in certain reimbursements for services and an increase in initial denials of claims for certain services provided. Accordingly, we re-evaluated the assumptions employed in our model for estimating revenue to be recognized for ResponseDXź testing. We view the code and price changes described above as affecting only the assumptions we used in pricing our services. The nature of the testing we provide, the evidence we gather to establish the creditworthiness of our payors and the delivery method of our services have not changed from prior periods, and there are no indicators that these assumptions require change.
We performed an analysis that considered our historical patterns of revenue by payor in conjunction with the fluctuations we experienced in the nine months ended September 30, 2013 to arrive at the revenue recorded during 2013. We believe that the changes in CPT codes and pricing that are causing confusion and erratic payment experience in the payor community will take some time to resolve. The time needed for resolution will depend upon Medicare and the local MAC releasing additional pricing changes and potentially, revisions to previously revised prices, and upon the private payor community adopting the new CPT codes and some level of revised pricing. Accordingly, our revenue recognition estimates could be materially affected in future periods as pricing and payments patterns change and develop, and we may be materially affected by future or retroactive price changes.
On July 8, 2013, the Centers for Medicare and Medicaid Services ("CMS") released a new proposed rulemaking entitled "Medicare Program; Revisions to Payment Policies under the Physician Fee Schedule, Clinical Laboratory Fee Schedule & Other Revisions to Part B for CY 2014". This proposed rule contains a number of provisions that may adversely impact the level of reimbursement for a variety of tests for which the Company receives reimbursement from the Medicare program beginning in 2014. Among other things, CMS has proposed examining approximately 1,200 laboratory tests that appear on the Clinical Lab Fee Schedule ("CLFS") over a period of five years to determine whether advances in technology may have reduced the cost of providing such tests and whether or not the level of reimbursement should be revised. The Company is currently performing molecular testing which is reimbursed using CPT codes that fall on the CLFS. CMS has also proposed changing the methodology used to determine reimbursement rates for the technical component of certain tests reimbursed off of the Physician Fee Schedule ("PFS"). Among other provisions, CMS has proposed limiting the Relative Value Units (RVUs) ascribed to the Practice Expense component of their reimbursement formula for tests performed in "Non-Facilities" (which would include most clinical laboratories like the Company) to the RVUs that have been ascribed for the same procedures under the Hospital Outpatient Prospective Payment System, or the Ambulatory Payment Classification ("APC") system which are used to reimburse "Facilities" (such as hospitals and ambulatory surgery centers). The Company currently performs FISH testing, which may be impacted by this PFS rule change if it is enacted. CMS has not yet proposed any specific rates for 2014 and the Company is examining the potential impact that a reduction in the level of reimbursement for the tests the Company offers may have on its operations. The final CLFS and PFS for 2014 are expected to be issued this month. Although we are unable to quantify the impacts of the proposed rules at this time, if they are enacted with a reduction in the level of reimbursement for the tests the Comany offers, they may have a material adverse impact on the Company.
License Fees
We have licensed technology for the extraction of RNA and DNA from FFPE tumor specimens from the University of Southern California ("USC") in exchange for royalty fees on revenue generated by use of this technology. These royalties are calculated as a fixed percentage of revenue that we generate from use of the technology licensed from USC. Total license fees expensed in cost of revenue under the royalty agreement with USC were $98,740 and $49,407 for the three months ended September 30, 2012 and 2013, respectively, and were $231,180 and $240,421 for the nine months ended September 30, 2012 and 2013, respectively. We also maintain a non-exclusive license to use Roche Molecular Systems, Inc.'s ("Roche") polymerase chain reaction ("PCR"), homogenous PCR, and reverse transcription PCR processes. We pay Roche a fixed percentage royalty fee for revenue that we generate through use of this technology. Royalties expensed in cost of revenue under this agreement totaled $105,170 and $47,158 for the three months ended September 30, 2012 and 2013, respectively, and were $249,057 and $221,665 for the nine months ended September 30, 2012 and 2013, respectively.
We are subject to potentially significant variations in royalties recorded in any period. While the amount paid is based on a fixed percentage from revenues of specific tests pursuant to terms set forth in the agreements with USC and Roche, the amount due is calculated based on the revenue we recognize using the respective licensed technology. As discussed above, this revenue can vary from period to period as it is dependent on the timing of the specimens submitted by our clients for testing.
Accounts Receivable and Allowance for Doubtful Accounts
We invoice our pharmaceutical clients as specimens are processed and any other contractual obligations are met. Our contracts with pharmaceutical clients typically require payment within 45 days of the date of invoice. We maintain allowances for doubtful accounts for estimated losses resulting from the inability of our clients to make required payments. We specifically analyze accounts receivable and historical bad debts, client credit, current economic trends and changes in client payment trends when evaluating the adequacy of the allowance for doubtful accounts. Account balances are charged-off against the allowance when it is probable the receivable will not be recovered. To date, our clients have primarily been large pharmaceutical companies. Bad debts to date have been minimal and there is no allowance for doubtful accounts for our pharmaceutical revenue at December 31, 2012 and September 30, 2013.
We bill Medicare and private payors ("Private Payors") for ResponseDXź upon completion of the required testing services. As such, we take assignment of benefits and the risk of collection with Medicare and Private Payors. We continue to monitor the collection history for Medicare and Private Payors. Based on the historical experience for our Medicare and Private Payor accounts, we have determined, based on a detailed analysis, that accounts receivable associated with certain billings are unlikely to be collected. Therefore, we have recorded an allowance for doubtful accounts of $991,990 and $1,159,756 as of December 31, 2012 and September 30, 2013, respectively.
An allowance for doubtful accounts is recorded for estimated uncollectible amounts due from the Company's various payor groups. The process for estimating the allowance for doubtful accounts involves significant assumptions and judgments. Specifically, the allowance for doubtful accounts is adjusted periodically, and is principally based upon an evaluation of historical collection experience of accounts receivable for the Company's various payor classes. After appropriate collection efforts, accounts receivable are written off and deducted from the allowance for doubtful accounts. Additions to the allowance for doubtful accounts are charged to bad debt expense. The payment realization cycle for certain governmental and managed care payors can be lengthy, involving denial, appeal, and adjudication processes, and is subject to periodic adjustments that may be significant.
We cannot guarantee that we will continue to experience the same credit loss rates that we have in the past. Measurement of such losses requires consideration of historical loss experience, including the need to adjust for current conditions, and judgments about the probable effects of relevant observable data, including present economic conditions such as delinquency rates and financial health of specific customers. We consider all available information in our assessments of the adequacy of the reserves for uncollectible accounts.
Income Taxes
We estimate our tax liability through calculations we perform for the determination of our current tax liability, together with assessing temporary differences resulting from the different treatment of items for tax and accounting purposes. These differences result in deferred tax assets and liabilities, which are recorded in our balance sheets. Our management then assesses the likelihood that deferred tax assets will be recovered in future periods through future operating results. To the extent that we cannot conclude that it is more likely than not that the benefit of such assets will be realized, we establish a valuation allowance to adjust the net carrying value of such assets. The carrying value of our net deferred tax assets assumes that we will be able to generate sufficient future taxable income, based on management's estimates and assumptions. These estimates and assumptions take into consideration future taxable income and ongoing feasible tax strategies in determining recoverability of such assets. Our valuation allowance is subject to significant change based on management's estimates of future profitability and the ultimate realization of the deferred tax assets. The Company has established a full valuation allowance against its net deferred tax assets due to the uncertainty surrounding the realization of such assets.
Results of Operations
Quarters Ended September 30, 2013 and September 30, 2012
Revenues: Revenues were $4,092,277 for the quarter ended September 30, 2013, as compared to $5,403,537 for the quarter ended September 30, 2012, a decrease of $1,311,260 or 24.3%. The decrease was primarily due to decreases in pharmaceutical revenues of $829,157 or 34.8% and ResponseDXź revenue of $482,103 or 16.0%. ResponseDXź revenue accounted for 62.1% of total revenue for the quarter ended September 30, 2013 compared to 56.0% for the quarter ended September 30, 2012. The decrease in ResponseDXź revenues primarily relates to our continued refocusing of the sales efforts toward larger accounts during 2013 and the correspondingly longer time period required to develop these relationships. Also contributing to the decline were continuing fluctuations in remittance rates from payors due to confusion in the payor community with respect to the new molecular testing CPT codes introduced in 2013. The decrease in pharmaceutical revenues was primarily due to a $500,000 milestone payment received during the quarter ended September 30, 2012 and for which no corresponding payment was received in the current quarter ended September 30, 2013.
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Grupo Radio Centro Reports Fourth Quarter And Year-End Results For The Period Ended December 31, 2009
MEXICO CITY, Feb. 24 /PRNewswire-FirstCall/ -- Grupo Radio Centro, S.A.B. de C.V. (NYSE: RC, BMV: RCENTRO-A) (the "Company"), one of Mexico's leading radio broadcasting companies, announced today its results of operations for the fourth quarter and year ended December 31, 2009. All figures were prepared in accordance with the Mexican Financial Reporting Standards ("MFRS") issued by the Mexican Board for Research and Development of Financial Information Standards.
Fourth Quarter Results
Broadcasting revenue for the fourth quarter of 2009 was Ps. 260,873,000, an increase of 12.8% compared to Ps. 231,342,000 reported for the fourth quarter of 2008. This increase was mainly attributable to higher advertising expenditures by the Company's clients in Mexico during the fourth quarter of 2009 compared to the same period of 2008, as well as broadcasting revenue from the Los Angeles radio station KXOS-FM. The Company began to sell advertising time on KXOS-FM in April 2009 pursuant to a local marketing agreement (the "LMA") with Emmis Communications Corporation.
The Company's broadcasting expenses (excluding depreciation, amortization and corporate, general and administrative expenses) for the fourth quarter of 2009 were Ps. 172,883,000, 38.5% higher than the Ps. 124,842,000 reported for the fourth quarter of 2008. This increase was primarily due to (i) broadcasting expenses incurred in connection with KXOS-FM, and (ii) higher commissions paid to the Company's sales force due to higher broadcasting revenue in the fourth quarter of 2009 compared to the same period of 2008.For the fourth quarter of 2009, the Company reported broadcasting income (i.e., broadcasting revenue minus broadcasting expenses, excluding depreciation, amortization and corporate, general and administrative expenses) of Ps. 87,990,000, 17.4% lower than the Ps. 106,500,000 reported for the fourth quarter of 2008. This decrease in broadcasting income was mainly attributable to the increase in broadcasting expenses, as described above.
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Photograph courtesy Museum of the Rockies via SI
Published October 16, 2013
National Fossil Day, an annual celebration of all things fossil, has come around again. But not everyone is jubilant. As the government shutdown ticks on—with debate fossilized, you might say—a mighty Cretaceous carnivore has been left in limbo on the day it was supposed to be acclaimed. There is no joy in Washington, D.C., for mighty T. rex has struck out.
The dinosaur in question, fondly known as the Wankel rex, was due to arrive today, shipped off from the Museum of the Rockies in Bozeman, Montana, for a ceremonial greeting at the Smithsonian's National Museum of Natural History. That warm welcome is delayed until the spring.
Even amid the other victims of the federal shutdown, the Wankel rex truly deserved fanfare. The skeleton is one of the most important Tyrannosaurus rex fossils ever found.
To date, fossil hunters have excavated roughly 50 T. rex skeletons, ones anywhere from 5 to 80 percent complete. (That's not counting all the isolated bones and teeth that have turned up.) That's actually quite impressive, making T. rex remarkably well represented by fossil standards.
But not all of these specimens are equally important. Some are literal rock stars. The Wankel rex is one of them.
A Rock Star Is Born
Discovered in 1988 by rancher Kathy Wankel, the fossil of this imposing predator was not only large, but the skeleton also included the first complete T. rex forelimb discovered by paleontologists. Based on past finds, they had expected that T. rex had short, stocky, two-fingered arms, but the Wankel rex finally gave researchers a complete look.
Mocking the dinosaur's puny arms would have been a mistake, though. A recent study found that the Wankel rex would have weighed in the neighborhood of nine tons, making it one hefty carnivorous customer.
Some Dinosaurs Are Bigger Than Others
But which was the most impressive and important T. rex ever found? There's no shortage of candidates, and each has its own charms.
One of the first distinctive T. rex skeletons ever found is now across the Atlantic at London's Natural History Museum (NHM). Discovered in 1900 in Wyoming, and later sold to the U.K. museum during the 1960s, the partial skeleton was originally given a different name.
American Museum of Natural History (AMNH) paleontologist Henry Fairfield Osborn first called the NHM skeleton Dynamosaurus imperiosus in the same paper that he named a different skeleton Tyrannosaurus rex. When he saw his mistake and realized both skeletons were the same species, he selected T. rex as the preferred name for the animal. Where old Dynamosaurus stands in relation to other T. rex isn't totally clear. "I don't think we have an accurate length estimate, as it's pretty fragmentary," says NHM paleontologist Paul Barrett. But one of the lower jawbones of this dinosaur is on display at the museum to give visitors some idea of the animal's size.
The One and Original
Much better known is the skeleton that Osborn originally dubbed Tyrannosaurus rex. That skeleton was sold by the AMNH to the Carnegie Museum of Natural History in Pittsburgh, Pennsylvania, in 1941 for the equivalent of $110,000 in today's dollars. As the representative fossil, it reigns as what Carnegie paleontologist Matthew Lamanna calls "the world's first specimen of the world's most famous dinosaur."
And the Carnegie T. rex is a big one. The complete femur of the dinosaur is about 4.2 feet long, and the latest analysis of the whole animal estimates that it was just over 39 feet long and weighed a little more than eight tons. "The holotype is estimated as a big, but not the biggest, known T. rex individual," Lamanna says. Still, the dinosaur will always hold the pride of place as the name-holder for the species.
Only One Can Claim the Crown
Of course, the NHM and Carnegie T. rex fossils were both early finds of important historical significance. They helped outline the image of what T. rex was like. But multiple specimens have been found since then, and they continue to be uncovered in the 68- to 66-million-year-old rock strata of western North America.
"While it is true that we are learning something from all the specimens," says University of Maryland tyrannosaur expert Thomas Holtz, Jr., "the most informative specimens have been Sue and Stan." Found in 1990 and 1987, respectively, these T. rex skeletons are the most complete found so far and nicely complement each other.
Sue, on display at Chicago's Field Museum, has become a fossilized atlas of T. rex anatomy by dint of being the most complete. And the virtue of Stan, kept at the commercial Black Hills Institute of Geological Research in South Dakota, is that the dinosaur "had a nicely disarticulated but complete skull, thus allowing us access to all sides of the various bones inside," Holtz says.
Who is the king of all T. rex is trickier to answer. "Sue does seem to be the largest one, or at least the largest one we can clearly determine the size for," Holtz says. This famous T. rex stretched approximately 40 feet long and is estimated to have weighed about nine and a half tons. But the largest T. rex may have been even bigger still.
Based on clues inside the microstructure of the dinosaur's bones, Holtz says, Sue was fully grown at the time of death. But individuals vary in how large they can get, and chances are that Sue represents the average full-grown T. rex rather than an extreme example. Given the way that animals vary in terms of size and growth, Holtz suggests that "it is very reasonable to suspect that there were individuals that were 10, 15, or even 20 percent larger than Sue in any T. rex population."
So, the biggest and baddest of the tyrant dinosaurs may yet be awaiting discovery by some lucky bone sharp.
Follow Brian Switek on Twitter.
I have heard that way back then, girls were bigger than boys. True??
@Charlaine Boa Girls are STILL bigger than boys in most species of animals - we mammals are kind of unusual. Fish, reptiles, birds... anything that lays eggs, pretty much, the females tend to be larger. So we can assume the same about dinosaurs, just like we'll assume the same about prehistoric fish. Girls larger than boys seems to be the "default" for vertebrates - it's only flip-flopped in mammals due to male/male competition (physical fighting) for mates.
Large size must be clearly beneficial in order to evolve, and since females are the ones that produce the babies and feed them, they generally need more calories and so must be able to hunt larger prey. That's why female hawks and owls can be up to 30% larger than the males!
@Charlaine Boa Exactly right
@Charlaine Boa Even though that theory is popular, I've to say no, obviously.
@Charlaine Boa ...but we haven't conclusively determined sexual dimorphism in any species of dinosaur. The few specimens we have that we KNOW are female, due to the presence of a special bone tissue we only see in pregnant, egg-laying females today, like birds (check out Mary Schweitzer's work on a T. rex called "B-rex," in North Carolina), are quite large though.
@Peo Huang @Charlaine Boa But are there any strong evidence that females are bigger than the males?
@Peo Huang @Charlaine Boa Are there any strong evidence that show females are indeed bigger than the males?
@Mohammad Abdullah @Peo Huang @Charlaine Boa Since it happens in all animals that the dinosaurs are closely related to, like reptiles and birds, we're kind of assuming that but exceptions could certainly occur. We don't know, because we can't yet determine males from females except in special circumstances, like Mary Schweitzer's research I mentioned above. Larger females is the default in vertebrates, so it's better to assume that for dinosaurs, rather than that they are like us unusual mammals.
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22 Feb 2013
Beauty Releases I'm Excited For #1
Unless you've been living under a rock, you will know that these beauties are being released next month.
Models Own Ice Neon Collection – These just jump out at me. They're bright and scream SUMMER is coming (hurry up). I've always wanted the perfect yellow polish but have never found one that I loved. This might be it!
There are five shades Pukka Purple, Bubblegum, Pink Punch, Luis Lemon and Toxic Apple.
I've loved so many Models Own releases and the recent Wonderland Collection was beautiful not to mention the Mirrorball Collection – they just always seem to have great collections. These are slightly different from previous collections as Models Own are recommending that you keep them in your fridge to stop the bright fluro colour from fading.
This new Ice Neon Collection is available online at modelsownit.com from March 20th (pre-order from March 1st for guaranteed March 20th UK delivery) Also available exclusively in the Bottleshop at Westfield on March 9th then will in Boots nationwide from March 22nd.
I will be picking up a few colours and popping them in the fridge – wonder what the hubby will say? Are you thinking of buying any? What colour are you most excited for?
11 Responses to "Beauty Releases I'm Excited For #1"
I'm the same with yellow polishes, have never found a really good one! I like the colours of these but not sure about storing them in the fridge x
I am so excited for these to launch. x
These look amazing! Too bad there are no boots stores near me =(
I'm so excited about this range from Models Own, bright neons are going to be perfect for spring, especially when worn with a monochrome outfit x
Models own always have such amazing collections! I'm excited to see & wear some bright colours this spring & summer! <3
These colours are amazing!! Really like the look of that purple shade!!
I really like the look of the purple shade, not really keen on yellows or greens. May check out Westfields next week then


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"Rise early, work hard, strike oil" - J. Paul Getty
Avanti Energy Inc. is a newly formed oil and gas company, listed on the TSX-V Exchange in Canada. Led by former YPF and Forest Oil senior executive, John McIntyre, Avanti has assembled a highly experienced team of international oil and gas professionals, formerly affiliated with Forest Oil. Avanti's mission will be to re-develop existing onshore oil fields in mature basins in the Lower 48 States and to apply such expertise in other parts of the world that have high netbacks and where incumbent national oil companies have begun to shift their focus away from maturing onshore oil fields in favor of larger opportunities offshore or in frontier areas.About Us


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Waukesha Springs Health Rehab in Waukesha Wisconsin has a 77% occupancy rate with 142 residents using its 185 beds. They are part of a multiple nursing home ownership and are a Non Profit nursing home.
Waukesha Springs Health Rehab has a below average registered nurse per resident per day of 37 minutes compared to the Wisconsin state nursing home average of 59 minutes. They had 22 deficiencies in its past 2 state inspections compared to the WI average of 10 and 15 complaints compared to the WI average of 3. Waukesha Springs Health Rehab had 19 fire safety deficiencies in the past 2 state inspections which is worse than the Wisconsin state nursing home average of 11.
Below is general facility information for Waukesha Springs Health Rehab in Waukesha, WI. More facility details are available on your free report.
Below are services offered at Waukesha Springs Health Rehab Additional services details and additional information are available on your free nursing home report.


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Cocktail Quiz
As cocktails become increasingly popular, gone are the days of the basic cocktail menu. Mixologists from across the globe are letting their culinary imaginations run wild as they concoct ever-more complex and delicious drinks. Did you get an A+ in mixology? Examine each list of ingredients and name that cocktail!
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Olivia Maxweller left her 9-to-5 job as a cake decorator and picked up art brushes and paint and embarked on another version of the sweet life: the life of a painter and sculptor. Her work is regularly displayed at the popular Kathy Womack Gallery in downtown Austin. In addition to still life and natural studies, Maxweller paints bar and music scenes, recalling her nights as a club promoter. "All of these experiences have inspired me artistically, and my work reflects them," says Maxweller. View all of Olivia Maxweller's work.
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Monday, December 13, 2010
Brett's Donutz
There's a new donut shop in town. My daughter, Brett has opened Brett's Donutz and it seems to be exactly what Gaffney has been waiting for.
Posted by Stephanie Earls at 7:09 AM
4 comments:
- Lynsey said...
YAY! I wish her the best of luck. Wish I could be there to support her in person...I love me a good donut!
- December 13, 2010 at 7:44 AM
- vendinggroup said...
i have tried the doughnuts! so good!
- September 26, 2011 at 5:22 PM
- Asian bride said...
When will Brett's Donutz" bob the footnote? Brett's Donutz" thinks over a kettle. The musical curse scraps the blessed. Brett's Donutz" hesitates in a picture.
- March 5, 2012 at 5:59 PM
- what is a mail order bride said...
Stephanie Earls sings an ignorance. Stephanie Earls ruins the mount over an intellectual abandon. Stephanie Earls hyphenates a research over every theory. Stephanie Earls muddles the console in whatever drill.
- March 5, 2012 at 10:11 PM
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The heat of summer is finally over! While that does mean the end of berries, lemonade and cobblers, the season of pumpkins, mulled cider and, of course, apple pie is now in full swing. To celebrate the season, I wanted to bake a non-traditional apple pie using only New England products (and, sneaking in one sweet addition from Brooklyn). The end result was an apple pie with a caramel lavender sauce and cheese crust. And to drink? Mystic Brewery's Mystic Descendant, a dry stout just bitter enough to offset the sweetness of the pie, with notes of caramel and toffee to complement. (more…)
Archive for the 'Desserts' Category
A Taste of New England: Pawlet Cheese and Lavender Caramel Apple Pie
Posted in Bakery Supplies, Cheese, Desserts, Grains, Rice, Flours & Beans, Local, Recipes, United States, tagged apple pie, baking, caramel, caramel sauce, Cheese, Consider Bardwell Farm, food, Four Star Farms, lavender caramel sauce, Mystic Brewery, Mystic Descendant, New England, Pawlet, recipe, Recipes, Spoonable, Vermont Butter & Cheese Creamery on October 27, 2013 | Leave a Comment »
Summertime Blues: Blueberry Pancake Ice Cream
Posted in Desserts, Recipes, tagged blueberries, dairy, food, ice cream, local produce, Maine blueberries, recipe, Recipes, summer desserts, wild blueberries on August 14, 2013 | 2 Comments »
We are in the throes of summer and our produce tables are teeming with blueberries! We have both local, cultivated berries and the wild Maine variety. I love blueberries. The tiny fruits burst with memories of childhood summers spent foraging for the sweet berries to bake muffins and pies.
There are so many ways to be creative with blueberries. One of my favorite treats as a child was a blueberry pancake breakfast. Of course, often during the summer there is less desire for a large breakfast. We spend our summer days soaking in as much outdoor air as possible, then relax with dinner and dessert. And, what makes a better summer dessert than ice cream? (more…)
Liège Waffles: Starring Belgian Pearl Sugar
Posted in Bakery, Bakery Supplies, Belgium, Breads, Desserts, Recipes, tagged Belgian Pearl Sugar, Belgian waffles, breakfast, dough, Liège waffles, sugar, waffles, yeast on April 3, 2013 | 30 Comments »
Growing up, my favorite waffles were, of course, Eggos. Flavorless, with a fun catch-phrase, they were the perfect vehicle for syrup and butter. It's no wonder that I always preferred pancakes at renowned breakfast restaurants, like IHOP and Denny's. In college, our cafeteria was equipped with a flip-waffle iron and a bowl of batter. You could make waffles at any time of day. But, after eyeing the thin batter and tasting the outcome, it was clear that these were merely pancakes posing as waffles.
Then, I moved to Massachusetts, where I learned a lot about food (Aunt Jemima's isn't real maple syrup!?). I worked at a creperie as a barista who didn't drink coffee. The crepes were filled with strange, exotic ingredients I had never heard of, like arugula and Brie. I also learned that the owner actually specialized in a variety of waffle called "Liège waffles" (also sometimes known as Belgian waffles). I had no interest in trying one – I knew what waffles were all about. But an extremely enthusiastic coworker convinced me to give it a go. She took the deep-pocketed rectangle, toasted it, got out the whipped cream and strawberries and impatiently watched as I took my first bite. And then my taste-buds exploded (with flavor, not literally exploded). Sweet, dense, yeasted, chewy, filled with sweet crunchy pockets of sugar that also caramelized on the surface of the waffle – why ruin this with whipped cream and strawberries? Eggos were no competition – in fact, I wasn't even sure if they were really waffles at this point – these were the best waffles I had ever had!
Capturing California Citrus: Candied Blood Orange Peel
Posted in Candy & Confections, Desserts, Produce, Producer Profile, Recipes, tagged Bill Zaiser, blood orange, candied blood orange peel, candied fruit peel, citrus, food, Linda Zaiser, Moro blood oranges, preserving, Rancho del Sol, recipe on March 12, 2013 | Leave a Comment »
Last Wednesday morning, as we received our weekly delivery of California produce, the wind was picking up and the clouds were grey and churning – a sure sign of snow on the way. As we hurriedly brought in the fresh greens, jewel-like lemons and first-of-the-season strawberries, the juxtaposition between the impending New England storm and spring produce from California was increasingly apparent. Unpacking a box of Moro blood oranges from Rancho del Sol, I was immediately hit with a rich, balsamic fragrance that was only matched in richness by the oranges' bright ruby appearance. Having yet to preserve any of this season's citrus fruit, I immediately decided to snap up a pound to juice and candy. (more…)
An Autumnal Taste Test: 10 Apple Varieties and 10 Apple Crisps
Posted in Bakery, Desserts, Produce, Recipes, tagged apple crisp, apples, baking, baking apples, crisps, eating apples, food, heirloom apples, pie, pie apples, raw apples, Recipes, taste test on October 17, 2012 | 6 Comments »
Inter-departmental cooperation? We've got that in spades! Two Sundays ago, this manifested itself in a team effort between the bakery and the produce departments. Emily, produce buyer and home chef extraordinaire, brought the apples: 10 different kinds, most of them heirloom varieties. I represented for the bakery and turned each variety into an individual mini-crisp and sliced extras for a "raw" tasting. Our goal? To find out which were the best baking and which were the best eating apples. (more…)
A Friend's Finishing Touch: Goat Milk Caramel
Posted in Dairy (non-cheese), Desserts, Recipes, tagged Beltane Farm, caramel, dessert, food, goat milk, goat milk caramel, recipe on May 5, 2012 | 1 Comment »
On weekends, we often have 12-16 people over for dinner. Since neither Ihsan nor I are big dessert eaters, someone else usually brings dessert. A couple of weeks ago, our good friend, John "Doc" Willoughby, brought a gingerbread cake and homemade goat milk caramel sauce. I have long been a big fan of anything made with goat milk, so I was thrilled with the dessert. Suffice it to say, we ate everything. (more…)
In the Bakery: Chocolate Fondue
Posted in Bakery, Chocolate, Desserts, Recipes, Valentine's Day, tagged bittersweet, Chocolate, fondue, test kitchen, Valentine's Day on February 13, 2010 | 2 Comments »
Yesterday, after I finished work, I popped into the back of the bakery and experimented with chocolate fondue. I wanted to do a test run because today, in preparation for Valentine's Day, we are sampling out fondue to customers. While chocolate fondue is not difficult to make, I wanted to make sure we had just the right ratios before preparing a large batch!
First off, I decided to use our Callebaut 60% bittersweet chocolate. Personally, I tend to like dark chocolate but, my own preferences aside, the acidity of chocolate is somewhat mitigated by the secondary ingredient in fondue: heavy cream. As a result, it is better to err on the darker end of the chocolate scale. (more…)


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Listening to the Inner Voices
Men were unattainable, almost otherworldly creatures given unlimited freedoms. I was always surrounded by females. My life was centered on women. My family, including relatives, is made up of entirely of women. The women in my family are all confident, strong women who made running family life, providing even essentials an unending act of love. But that feminine confidence did not pass to me, I thought, as I had my life centered on men, trying to emulate the males I knew.
My family life would set the pace for the rest of my life. My school life from kindergarten years to tertiary education consisted of more women than men. I had more female than male teachers. My classroom showed more girls than boys especially during secondary school where I attended an all girls school. University should have shown some improvement; however, my lectures and tutorials were consisted mostly of females as the university population illustrated a 8:2 ratio of women to men.
I lived in an all girls dormitory for most of my years at university. Two years ago, a few females and a female administrator from the university took up the task of improving the lives of young girls outside the university most girls especially within inner-city and rural communities. They created the I'm Glad I'm a Girl Foundation, an organization by young women for young female adults aimed towards giving young girls ages 13 to 17 with skill sets for protecting themselves, to change and impact their young charges they adopted, giving them positive role-models that they can emulate, creating a safe haven with females close to their age that they can relate and share experiences and providing the support they needed to be young females.
It is becoming a part of this group that I understood the importance of females in the world, their significance was undervalued, under appreciated and even underestimated and in some way I had contributed to a cycle. By socializing with young females, I realized that they too had been disillusioned into the belief that they were worth less that they thought, that their hair was not of what society deemed "quality", their skin was not of a standard that was considered beautiful, their body was an object for sexual gratification or displeasure to used as another believed, and their minds were depressed, negative and under appreciated.
Thus began the challenge to publicize the organization, to gain aid in continuing our foundation and be spokespersons for the girls and females and join in the world in empowering and celebrating females and World Pulse was the perfect avenue to begin. After scouting the website, we came across the Voices of Our Future competition and I decided to enter. In entering, it is considered that the journey toward the future has begun. It is sensitization of governments, organizations, businesses and citizens, male and female, on the significance of women and girls, the power of their worth and contribution that they can may towards all areas of life.
This lovely Latoya. Keep writing!
The Power of role Models
Dear Latty,
You write of a powerful internal transformation from a life you felt was too circumscribed by women to one where women are essential. I want to learn more about the I'm Glad to be a Girl Foundation. It targets a critical time in the development of young women, ages 13-17. I imagine that the biological sisters as well as the social sisters in your life have had a profound impact on you, an impact that you will continue to uncover as the years pass.
In your "journey toward the future" you will be an inspiration for the next generation.
Your sister in the US,
Jan Askin
Jan Askin
Interesting story
Dear friend,
Thanks for sharing these valuable insights in a creative manner. Look forward to more from you.
You are creating a new world
Dear Latty -
YOu are a wonderful writer - what a journey! Thank you for devoting your life to create safe havens for girls.
Jensine Larsen
World Pulse


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MidEast sukuk issuance seen over $14B in 2012 – HSBC
The issuance of Islamic bond, or sukuk, in the Middle East could reach over $14 billion this year, according to HSBC, as investor demand and the relatively lower volatility of the asset class drive sales.
March 7, 2012 2:02 by Reuters
HSBC forecasts global sukuk volumes of $44 billion in 2012, of which the Middle East region could comprise just over 30 percent, the bank's Islamic arm Amanah, said on Tuesday.
Malaysia will continue to dominate sukuk issuance, with about 60 percent of total volumes forecast globally.
"One of the key drivers of this will be the continued level of liquidity within the overall Islamic investor base, whether in Middle East or Asia, the market is still very much characterised by a high degree of liquidity and relatively limited levels of supply," said Mohammed Dawood, managing director of Islamic global markets for EMEA.
"From a volume, country, and issuer perspective, 2012 is going to be a year when this market will continue to make its mark."
Asked whether a possible sukuk default by UAE's Dana Gas would affect forecast sukuk issuance this year, Dawood said it wouldn't be "helpful".
Dana Gas has a $920 million sukuk maturity due in October. It has hired Deutsche Bank to advise on the Islamic bond and address investor concern on a repayment plan.
The United Arab Emirates and Saudi Arabia are likely to dominate the regional sukuk issuance landscape. So far this year, Emirates Islamic Bank and First Gulf Bank , as well as private corporate and a first-time issuer, Majid Al Futtaim Holding, have issued sukuk.
In Saudi Arabia, the General Authority for Civil Aviation (GACA) issued a $4 billion equivalent riyal-denominated bond in January. The government-backed bond, on which HSBC acted as arranger, is the largest single tranche sukuk to date.
"We increasingly expect that businesses consider sukuk as a reliable and permanent source of capital (in Saudi Arabia) … and the number of investors and the appetite for sukuk is growing," said Muhammad Farhan, head of Islamic Finance at HSBC Saudi Arabia. (Reporting by Rachna Uppal; Editing by Firouz Sedarat)
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