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The new musical Chaplin is bringing the silent film era to Broadway, starring Rob McClure as the legendary screen icon. Find out if new Broadway.com Word of Mouth panelists Elissa, Yiping and Brian enjoyed their bittersweet journey to Hollywood.
If/Then star James Snyder heads to the airport, a coffee house, a recording studio and his dressing room for a fun chat with Jackie Burns.October 3, 2014
Almost Home star Jonny Orsini talks about the show's authenticity in portraying a Marine returning to the Bronx in 1965.October 2, 2014
Money Grubbin' Whores star Adam Mucci on the heart, foul language and emotional center of the new off-Broadway play about marriage, divorce and communication.October 2, 2014
As the stars of Side Show, Erin Davie and Emily Padgett are Broadway's newest dynamic duo. Find out why in this exclusive music video of 'I Will Never Leave You.'October 1, 2014
In this week's episode, we gear up for a load of new shows, celebrate Broadway romance, cheer for a Hollywood star's awesome debut and get a glimpse at a special Saigon performance.October 1, 2014
You Can't Take It With You is back on Broadway, starring James Earl Jones, Rose Byrne, Kristine Nielsen and Annaleigh Ashford. See what the stars had to say on opening night!September 29, 2014
Watch Isabel Rose preview a song from her CD release show at 54 Below.September 29, 2014
The Curious Incident of the Dog in the Night-Time has arrived on Broadway, featuring Alex Sharp as Christopher, a peculiar teenage boy who sets out to solve a murder. Click for clips from the new production, opening October 5!September 29, 2014
The "gender-flex" star of Hedwig and the Angry Inch talks about her hard-rock image, her uncool other side and her long Broadway journey to Tony glory.September 26, 2014
You know the one about the bread? The stars of Rock of Ages totally do as the explain Les Miserables in the latest episode of Drunk Broadway.September 26, 2014
Nick Blaemire chats with Broadway.com about the ambitious new musical Found, which tells the story of a man finding his connection to the world through discarded notes and flyers.September 26, 2014
The cast of Second Stage Theater's revival of Terrence McNally's Lips Together, Teeth Apart (America Ferrera, Tracee Chimo, Michael Chernus & Austin Lysy) meet the press.September 25, 2014


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Estrella Tassel Necklace
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text: No. 3 Michigan State had to battle on Tuesday night to hold off Indiana 71-66 in East Lansing. The Spartans have won 11 in a row and remain unbeaten in conference play at (7-0). MSU is 18-1 overall. Gary Harris scored 20 of his 24 points in the second half, while Branden Dawson added 13 points in the win. Michigan State will host Michigan on Saturday.


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George Ryan to be released to halfway house in late January
By MICHAEL SNEED firstname.lastname@example.com January 19, 2013 3:26AM
George Ryan
Article Extras
Updated: February 21, 2013 6:48AM
The Ryan report...
Inmate #16627-424 is going home. Well, almost.
Sneed has learned former Gov. George Ryan, who has spent a little more than five years in federal prison on corruption charges, is scheduled to be released on Jan. 30 and sent to a halfway house on Chicago's West Side.
◆ Backshot: Ryan, whose formal release date is July 4, lost his beloved wife, Lura Lynn, to cancer, and his brother, Tom, the former mayor of Kankakee, to pneumonia while the ex-governor was in prison at a facility in Terre Haute, Ind.
◆ Upshot: It's not unusual for inmates to leave prison six months early to enter a halfway house closer to their home. Although the Federal Bureau of Prisons will not comment on the release plans, Sneed has verified the date through numerous sources familiar with friends Ryan has made in prison.
◆ However, Sneed reported last August — via Ryan's lawyer, former Gov. Jim Thompson — that Ryan would begin serving the last leg of his sentence in January when he enters a work release program.
◆ Backshot: "He's been sad, he lost a vital segment of his family," said a close Ryan friend who asked to remain anonymous. "How would you feel? He was married to Lura Lynn for 55 years, and she was his childhood sweetheart."
Since entering prison, Ryan has spent his time reading books, working in the prison shop, and walking miles each day.
Last September, Ryan's only son, Homer, told Sneed: "But I know the first thing he'll do when he gets out is to visit Mom's grave and take care of the house [in Kankakee]. He'll be 79 years old when he comes home [from the halfway house]."
◆ Back story: Ryan and his wife, whom he courted while walking miles to her farmhouse, raised their brood of six children in an old Victorian house in Kankakee where he enjoyed power-washing his porch and making homemade beef vegetable soup.
◆ Back chat: Ryan once told Sneed he left behind two notes to his gubernatorial successor, former Gov. Rod Blagojevich, who is now serving a 14-year prison sentence on corruption charges in a federal prison in Colorado.
◆ Quoth Ryan to Sneed years ago: "One note he [Blago] was to open when things get tough. It contains my best personal advice, which is: 'When things get tough, blame me.' "
◆ The second envelope: "It contained my final advice: 'When things really get tough, get two envelopes.' "
◆ Ryan also told Sneed he left Blago a six-pound can of spinach at the governor's mansion "just in case he needs a little bit of Popeye's strength."
◆ The irony: Since then, the man who chastised Ryan for corruption is now in prison on corruption charges.
It's now time for Ryan to come home.
Pat's chat...
Sneed's scoop on former U.S. Attorney Patrick Fitzgerald being named a new trustee at the University of Illinois, which has been plagued by a student admissions scandal, netted this comment from Fitzgerald, Gov. Pat Quinn's personal pick:
"I am terrifically excited to join the board and help in any way to make a better institution. I'd love to do it and I start next week. But there is no special assignment. My assignment is showing up. But I will be showing up with both ears open."
Over and out.
A Tiger's tale...
Scratch the tabloid twaddle Tiger Woods proposed over the Christmas holiday to ex-wife Elin Nordegren, who allegedly claimed she'd do it for a pre-nup — including a $350 million anti-cheating clause.
A friend of Nordegren tells Sneed the story is "farcical, bogus, absolutely fiction, false and that she is spending her time being a lovely mom raising her lovely kids." So there.
Inaugural musings ...
At last peek, Oprah Winfrey will not be going to her good buddy President Barack Obama's inauguration ... and neither was Illinois House Speaker Mike Madigan planning to go.
Sneedlings ...
Saturday's birthdays: Desi Arnaz Jr., 60; Dolly Parton, 67; and Luc Longley, 44... Sunday's birthdays: Bill Maher, 57; Lorenzo Lamas, 55; and David Lynch (right), 67.


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Submitted by CubicleZombie
CubicleZombie (2590497) writes "As part of last year's U.S. federal debt increase deal, the Department of Defense will take a $55 billion budget cut on January 2nd. That's a lot of IT jobs. By law, companies are required to give 60 days notice before mass layoffs. Only this time, they're not, because the Obama administration has directed companies to ignore the law and has pledged tax dollars to cover their legal defense. These notices would have come out days before the November election."
This discussion was created for logged-in users only, but now has been archived. No new comments can be posted.


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This where the flash should stand...
Geneva International Music Competition 2011 : Breguet rewards young talents2011.11.20
For the tenth consecutive year, Breguet chose to lend its support to the Geneva International Music Competition,where talented young musicians are honoured and some are even offered a chance to record a CD. Several prizes areawarded annually.
In the String Quartet final held on November 20th, and for the first time in the competition's history, two First Prizeswere awarded: one to the Armida Quartett from Germany; and the second to the Quatuor Hermès from France. Theseeight youthful talents each enjoyed the privilege of receiving a Breguet watch.
The jury, composed of Gene va International Music Competition judges and discerning music -lovers, also made apoint of rewarding the Quatuor Hermès for its magnificent interpretation of "Ainsi la nuit" for string quartetcomposed by Henri Dutilleux and of Beethoven's Quartet N°12 in E flat major Op. 127, by awarding it the "Coup deCoeur Breguet" Special Prize. This prize offers the winners a chance to record a CD in order to develop their alreadypromising artistic career.
Within this context of fostering burgeoning vocations, the young Korean pianist who won the "Coup de CoeurBreguet" Special Prize in 2010, Hyo Joo Lee, was officially presented with her CD during the Gala Dinner of this 2011edition.
Quatuor Hermès – France
Omer Bouchez, aged 22, first violin
Elise Liu, aged 24, second violin
Yung-Hsin Chang, aged 25, viola
Anthony Kondo, aged 26, cello
Armida Quartett – Germany
Martin Funda, aged 26,first violin
Johanna Staemmler, aged 24, second violin
Teresa Schwamm, aged 23, viola
Peter-Philippe Staemmler, aged 25, cello


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text: DIGITAL TREASURES : Item Viewer home : browse : advanced search : preferences : my favorites : about : help add to favorites : reference url back to results : previous : next Hopkinton Firemen, Image 2 TitleHopkinton Firemen, Image 2 Full Size Imagehttp://dlib.cwmars.org/cdm4/images/full_size/hopkinton/42.jpg SubjectFire fighters-Massachusetts-Hopkinton;Fire engines-Massachusetts-Hopkinton; Centennial celebrations, (Hopkinton, Mass.); Parades-Massachusetts-Hopkinton DescriptionTwelve standing firemen in uniform and one seated in a horse-drawn fire engine, pose for a photograph during Hopkinton's 200th Anniversary Celebration in 1915. A sign behind them reads 'I fought for Hopkinton 1882 & 1900', referring to two major Hopkinton fires. There are other uniformed men standing in the rear. An inscription on the left refers to the 200th anniversary, on the right refers to 'Willard photo #18'. PublisherC/WMARS http://www.cwmars.org Date1915 Typeimage Formatimage/jpg IdentifierCloset Box 8, File #16 Source3.5 x 5 in. photo postcard Languageen-US RelationFrom The Hopkinton Public Library Treasure Room Coverage42.22861N; 71.52306W RightsPlease request permission in advance to use image by contacting add to favorites : reference url back to results : previous : next powered by CONTENTdm ® | Contact: June Stokoe ~ Digital Initiatives ~ C/W MARS ^ to top ^


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Medal of Honor Blu-ray
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- Format: Blu-ray
- Rating: TV-PG
- Number of Discs: 2
- Run Time: 4 Hours 4 Minutes
- Studio: Mill Creek Ent
- Blu-Ray Release Date: April 3, 2012
- Genre: Documentary
This 6-part documentary chronicles the highest award given to military personnel for their extreme bravery, valor and harrowing sacrifices. Covering the Civil War through the wars in Iraq and Afghanistan, learn about the most courageous acts performed by the people who fight for American freedom. These are their stories"¦
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Part 1: The Civil War
Part 2: World War One
Part 3: World War Two Europe
Part 4: World War Two Pacific
Part 5: The Korean War
Part 6: The Vietnam War
Celebrate Our Nation's Heroes in Spectacular High Definition


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Thank you for entering me
What a gorgeous layout!
Congrats Mocamom!
Gorgeous LO Rachel and I'm sure the kit is too!
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Josh and the team decide to try a touristy Vampire haunted house before the investigation and realize sometimes that's scarier than the real thing.
Josh talks about why sometimes slowing down during your travels is the best course of action.
Josh gives you a sneak peek as to what to expect from the Hanging Coffins investigation.


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Satorri's talks about stuff like this on his new 'guide' in this exact forum. I suggest that you go read it.
I personally run my spec with RT/IRT because I like the extra little "health stone" if you will. I know alot of DKs say that your healers should be healing you, but every top DK Tank I can find, uses RT/IRT.
Personally if I was to take those 4 points out, I'd dump them in Necrosis for extra threat, but what do you guys say?
I probably won't change my spec because it currently works for me, but I'm always looking for tips/tricks to see if something could work better.
Satorri's talks about stuff like this on his new 'guide' in this exact forum. I suggest that you go read it.
You should definitely put a point into shockwave.
True Knowledge exists in knowing that you know nothing.
Agg's tanking guide
amg, I LOVE shockwave.
Here's where I'd put those points:
The (Old) Book on Death Knight Tanking
The New Testament on Death Knight Tanking
Only on my Blood Tank, because that's how Blood Tanks work. Doing it for Frost Spec means you're sacrificing valuable threat tools.
Whether you take it depends entirely on the content you are doing, and how much you trust your healers.
Normal modes and farm content I never touch RT, but on the fun progression night wipe-a-thons I watch my runes carefully to manage my DS and RT.
Personally I love RT and the dps is never on my heels for threat, so I don't mind putting the four points into it for more survivability.
[ vine's TankUI & HealUI ] *UPDATED*
Honestly, 4 points is a huge investment. I'm usually far too distracted maintaining good threat, watching adds, moving out of fire, and being ready to interrupt to even begin thinking about watching my health and having a blood rune ready to go to heal.
My healers invest nearly all their time watching my health bar ready to pop a heal. I really don't see how I could be any better with an every once in a while heal. It really comes back to 4 points though.
Which top DK tanks are you talking about?
Personally, rather than dropping Rune Tap, we drop a healer or two for content where I just don't require as much healing. =)
Nice steps up in dps, adding more damage dealers, ya know.
The (Old) Book on Death Knight Tanking
The New Testament on Death Knight Tanking
I like Rune Tap as "just in case" sort of thing. normally it's not an issue- but what a healer gets hit by Bone spikes and someone else can't get to you in time... BUT WAIT! you've got Rune Tap and can use it push yourself up enough to not die on the next hit! I only use it if it looks like something good go bad and if I feel myself getting really low and sitting there for a while before a heal.
My guild normally runs with one or two heals- three on certain fights in ICC ( cough DBS cough).
Most "top" DK tanks don't take it, and you will see a lot more people switch to Frost specs as armor gear is accumulated.
I don't take it myself because in every situation where I would die, I am stunned, incapacitated, or the burst comes before a global would reset. If I did heroics or 10 mans were progression for me, I would definitely use it. The less bosses hit for, the more valuable it becomes.
talents depends on guild content, i don't use it too, i don't use mark of blood either, i build my spec to do good threat, since i have tons of survival just from gear
armory : The World of Warcraft Armory
I actually don't find Rune Tap to be a very good clutch tool at all. There are times in which I use it as such and it works wonderfully, but that's not why I take it. Rune Tap is taken, by me, for Blood spec, because it's part of how a Blood Tank works in my opinion. The mitigation for Blood Tanks comes from a reactive response in healing much of the damage they take in. Death Strike is nice, Vampiric Blood is nice, but Rune Tap is also added to those and it should be used as often as possible without wasting it on overheals. It lightens the stress on your healers by putting you on par with the damage on you that they should be healing had you had your healing as mitigation instead.
People seem to forget something about RT regarding threat: it may not be as good as 4 points in necrosis or wherever but it's not 0 threat either. If you use regularly and it heal you for full it's a good amount of threat.
At least it's not a lost to use a rune on it, regarding threat; as long as you are not full health and it's not an AOE situation.
I smell crack smoke in this thread..
If you need RT to stay alive gkick some healers and get better ones >.>
Personally if things get that bad that I need to top up beyond a DS, VB+DP..
I personally dropped the talent since i stopped leveling i always saw it more as a solo tool and then an optional one aswell.
I never had the need for it and i believe it's more personal play style then anything else.
I can see it's purpose as a raid heal tool however but then it's more of a ninche for certain fights then a must have still in my eyes, such as anub'arak heroic.
I find mark of blood, vampiric and IBF to be enough.
It's never a matter of need, but a matter of survival value you can offer.
If your health drops, as it always does, the tank who can instantly restore a third of their health will save their healers work, often remove the risk of a sudden dip-gib, and generally appear less squishy.
Not everyone chooses to gear, spec, or use all the tools available to survive better, some people would rather focus on threat and leave the survival to their healers.
It's a choice, but there isn't a right one and a wrong one.
So long as you are holding threat off your team and not capping their dps with your threat, you're doing enough threat.
So long as you're living through the fight, you clearly have enough survival value.
What you buff after that is your call and really it's just a matter of how you're trying to support your team.
The (Old) Book on Death Knight Tanking
The New Testament on Death Knight Tanking
I get Satorri's point, although I'm not a fan of RT either.
But this:Is not true.Death Strike is nice, Vampiric Blood is nice, but Rune Tap is also added to those and it should be used as often as possible without wasting it on overheals. It lightens the stress on your healers by putting you on par with the damage on you that they should be healing had you had your healing as mitigation instead.
RT is for emergencies and not to pop it when it is off it's cd...that won't reduce overheal and won't increase your survivability.
Maybe in a fight with really really massive group damage, if your healer needs to heal group as well...but can't really imagine that situation...
If I want to rely solely on my healers, I'll tank in Frost, why bother with Blood? Isn't the whole point of Blood the self healing?
=) Unless you like Blood's threat style, which many people do.
The (Old) Book on Death Knight Tanking
The New Testament on Death Knight Tanking


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SPONSORED: Bloggers Decorate with Target's Threshold Collection
See how seven StyleCoalition bloggers use Target's new pieces in their homes
By ELLE DECOR Promotions
White Honeycomb Vase - The City Sage
"I've been steadily building a collection of ceramic containers, and this honeycomb vase from the Threshold line at Target is the latest addition to the family. It's that just-right shade of white and sits in the 'not too modern, not too traditional' camp. I recently did an easy bouquet with flowers I picked up at the grocery store and kumquats branches from the yard."
Anne Sage, Spring Flower Arrangement DIY: White Honeycomb Vase


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Heather Brady, wtop.com
WASHINGTON - A few weeks after its season opening, Salt Lake City's Ballet West is making a mid-season shift to the East Coast to perform "The Nutcracker" at the Kennedy Center.
The Utah dance company's production is America's oldest full-length ballet and was lauded as the best "Nutcracker" in the United States in 2010 by The New York Times.
This season marks the first time Ballet West will perform "The Nutcracker" in Washington. Ballet West artistic director Adam Sklute says he suspects the glowing Times review of their "Nutcracker" captured the Kennedy Center's attention and spurred an invitation to perform.
Logistically, packing up a ballet midseason and shipping it east presents a challenge. The company timed every step of the transition and worked closely with "The Nutcracker's" show designer to move it effectively without losing any of its charm.
Four casts will perform in Washington, and the production features 75 children who perform alongside the company's adult dancers. For the shows in D.C., Sklute worked with a local ballet teacher to choose children for the roles and teach them the steps. All but two children in the Ballet West shows at the Kennedy Center are from the D.C. area.
The company traveled east Tuesday and starts performing Wednesday, leaving time for only one full dress rehearsal onstage and a few smaller run-throughs.
Sklute and the show's production director have danced and worked at the Kennedy Center before, which gives them an advantage. The sets, costumes and other show materials were shipped to D.C. in advance, with Sklute praying that the trucks wouldn't be hindered by unexpected weather conditions.
Ballet West: "The Nutcracker"
Where: Kennedy Center Opera House
When: Dec. 5-9
Cost: $45-$150
Website: http://www.kennedy-center.org/events/?event=BNBSD
Despite extensive rehearsals in Salt Lake City, dancers are fretting about the short turn-around.
"I can't talk myself down from it," says Christiana Bennett, Ballet West's principal artist who has played the role of the Sugar Plum Fairy since 2000. "That's the one thing that I'm really nervous about, but I'm very lucky. I've been dancing with my partner for years, and years and years now, so I have that comfort level going with me."
Bennett has danced in D.C. before, but she says any disruption of a dancer's meticulously crafted daily routine can be nerve-wracking.
"We're very regimented people -- we like schedule, we like things a certain way," Bennett says.
The production is based on a version created by Willam Christensen for the San Francisco Ballet in the early 1940s.
"When he moved back here to Utah and founded Ballet West, he brought his version (with him)," Sklute says.
Bennett says the company's roots in American ballet's beginnings remind her how important it is that dancers never forget where they came from. The energy Ballet West brings to the stage reflects the dancers' passion, she adds.
"We have a lot of personality, and we have a lot of love for what we're doing," she says. "I think that definitely transcends the footlights."
The history and tradition of "The Nutcracker" is what keeps audiences coming back year after year, Sklute says. Christensen created his production without seeing the original Russian version, so Ballet West's "Nutcracker" is also unique.
Tom Mattingly, a first soloist in the company, says it is easy to follow the storyline.
"Children can come to the ballet and see the beautiful costumes, and the tutus and something sparkling and beautiful dancing, but also seeing real people onstage and seeing the party scene, seeing the battle scene," Mattingly says. "It has everything, but nothing that it doesn't need."
For the performances in D.C., the company is looking forward to dancing at sea level. Mattingly, who dances the notoriously difficult pas de deux with the Sugar Plum Fairy in addition to several other roles, says the steps will be easier at a lower altitude compared to Utah.
For Bennett, the trip east provides a special chance for her parents to see her. They are traveling from Massachusetts to watch her perform.
"It's not every day that they get to come and see us, so being on the eastern seaboard for me is particularly special," Bennett says. "I feel like this is a little bit of Christmas for me."
Follow @WTOPLiving on Twitter.
(Copyright 2012 by WTOP. All Rights Reserved.)


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Paula Wolfson,
WASHINGTON - The U.S. is a nation of soda-holics. Nearly half of all Americans drink soda daily, and not just one glass or can. The average American drinks 2.6 glasses of soda a day, a Gallup survey indicates.
Each 20-ounce serving of regular soda contains up to 15 added teaspoons of sugar, and nutritionist Margo Gladding says many drinkers don't even know it.
"People are drinking them in excess and they are getting extra calories that ultimately harm their health," she says, citing an increased risk of cardiovascular problems, obesity, diabetes, tooth decay and bone loss.
New York City has banned the sale of extra large sized sugary sodas, and the Center for Science in the Public Interest recently filed a petition urging the Food and Drug Administration to set safe limits for the amount of added high-fructose corn syrup in beverages.
Meanwhile, questions are being raised about the chemicals in diet soda, including concerns that artificially sweetened beverages can actually cause someone to crave sugar-laden foods.
"It is tricking the body into thinking more sugar is actually coming, that addiction of wanting sweet, sweetness is still there," says Gladding, who believes diet soda is just as bad as the full sugar kind, maybe worse.
So what is a poor soda drinker to do?
Gladding says the best course is to quit cold turkey. But she acknowledges it is tough to kick the soda habit.
"For some people, slowly weaning themselves off is the best approach," she says. "It is about replacing and eliminating."
She says there are great alternatives. Start with plain carbonated water to keep the fizz and add some lemon, lime, a bit of ginger or some mint.
Gladding says tea is a great choice, hot or cold. Some teas, including ginger, chai, or licorice, have a bit of natural sweetness.
She also says the best thing parents can do for their kids is to never give them soda in the first place.
At a busy table in the Union Station food court Tuesday, Debby, a mom from Connecticut, says she strictly limits her children's soda consumption.
"It is only when we are out of the house. We are on vacation now. It's for special occasions, but we don't really have it in the house," she says.
At the University of Maryland, the student union offers plenty of sodas on tap. A student named Sarah sips on her Dr. Pepper and acknowledges that while she has thought of quitting, "it normally doesn't happen."
Her friend Chelsea nods in agreement.
"I like the taste, also the caffeine," she says.
But other students nearby drink water and juice. And the beverage industry is aware of their non-soda preferences too.
The American Beverage Association says the industry is working to increase options for consumers, and major companies are campaigning hard against their critics.
Related Stories:
- Coca-Cola to address obesity for first time in ads
- Scientists ask FDA to act: Coke and Pepsi are unsafe
- Studies more firmly tie sugary drinks to obesity
- New York City's new sugary drink rules
WTOP's Julianne Pelusi contributed to this report. Follow @WTOP and @WTOPliving on Twitter.
© 2013 WTOP. All Rights Reserved.


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Form and Substance: Designer Faye Toogood's Poetic Objects
After a career at the British magazine The World of Interiors, Faye Toogood is finding acclaim as a designer of stark yet poetic objects
By Stephen Patience
Spade chair in patinated bronze
Reworkings of her signature Spade chairs are dotted around her canal-side studio in the London borough of Islington. True, the original blond-wood design does have a certain English-country-garden quality, with three slim legs that suggest cricket stumps and a distinctive backrest based on the silhouette of a gardening tool. But its later iterations are darker, in both hue and inspiration—the chair has been recast in rough, anodized aluminum, sewn up in a leather sheath, sealed in black rubber. A recent version in patinated bronze, available exclusively through Phillips de Pury, recalls the iridescence of an oil slick.


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Valid Dec. 9, 2013 - March 31, 2014. Voucher can be used at Malcolm's or Brandon's on the Beach at The Omphoy Ocean Resort. Reservations required; subject to availability. Valid Sunday-Thursday during merchant's operating hours. Please tip on the full value; 18%-20% is customary for good service. Limit two vouchers per table. Not valid on holidays or holiday weekends. Limit two purchases per person; may buy two additional as gifts. If limit is exceeded, voucher subject to forfeiture.See all terms
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Loved the spa and hotel faciliteis, i can't wait to go back!
|Jul 21, 2014 Natasha FL, United States
The food, the view but the special service by Greg and professional courtesy by Walker
A must for your weekend!!
|Jul 14, 2014 Susan Fl, United States
The food, service and ocean view all wonderful! Thanks to Helen the manager for making an exception when i called to ask, if they would accept our voucher a day late.
Always a great experience. We spent out wedding anniversary her in June, also enjoyed a couple's massage and a steak dinner with yet another incredible view of the ocean and good food/service.
|Jul 14, 2014 Dawn FL, United States
The buffet was not available .We had to choose from the regular breakfast menu The choices were limited.There is a $10 service charge. A breakfast at any local restaurant would have been superior and less cost.
|Jul 11, 2014 herbert FL, United States
A bit disappointed as they had discontinued the brunch a couple weeks prior to our visit. They did honor the voucher for full value towards the regular menu.
|Jul 08, 2014 Joseph Florida, United States
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LomographySF - Portraits PhotowalkThis photo was shot on film. Taken by sixsixty with a Bronica SQ-B loaded with Ilford HP5 Plus 400 film in San Francisco, California, United States. These tags describe this photo: 2012, lomographysf, blackandwhite, and b&w. Date: 2012-07-14. Time: Afternoon. This photo can also be found in the album LomographySF - Portraits Photowalk.
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Trains Unlimited: Great Train Disasters DVD
Sale Price: $19.99
To Order by Phone Call 1-800-933-6249
- Additional Details
- Format: Color, DVD-Video, NTSC
- Rating: Not Rated
- Number of Discs: 1
- Run Time: 50 Minutes
- Region: Region 1
- Aspect Ratio: 1.33:1
- Language: English
- Studio: History Channel
- DVD Release Date: December 1, 1997
Graphic footage and the testimony of survivors is featured in this troubling look at railway accidents from the dawn of the steam age to today.
In the early days of the railroads, as robber barons rushed to lay more track than their rivals and the lure of commerce pushed the rails further into the wilderness, accidents were commonplace. In 1890 alone, over 6,000 people were killed and 35,000 injured in train accidents. Today, rail travel is much safer, but a surprising number of train trips still end in disaster.
GREAT TRAIN DISASTERS is a riveting, disturbing journey through the dark side of rail travel. Period reports and photographs detail the many problems that dogged railroads in their infancy, from exploding boilers to washed-out track. See stunning footage of more modern accidents and their aftermath, and explore what can be done to make trains safer with officials and experts. And hear harrowing tales of disaster from those lucky enough to survive.


text: 2 Am I playing the right game???reinhard | 27/04/2008 | See all reinhard's reviews (3)Well, it says on the box gears of war and also on the disc itself but this weak attempt seriously cannot be the game that i have heard people raving about for so long. I would really like to ask the other people who have given this game such good reviews if they have ever played BLACK on the xbox or even Halo 1 which is almost 5 years old now. Both of these games are far superior to GOW. As somebody who has been a fan of shoot em ups for 15 years I was amazed at how the gameplay is so weak even in comparison to goldeneye on the nintendo 64 and even further back than that Duke Nukem on the PC. THOSE were games with real playability. Graphics are ok but nothing special. I think the main problem is that you are controlling a clumsy oaf who likes to slam into walls and do forward rolls with the elegance of a hippo. I had to try and force myself to play it just to give it a try but it never got any better. I found myself plugging in my old x box after a very short period of time and playing a real game like Hitman, Blood Money. This game has the advantage that you can actually control the person in the game. This tends to help when people are attacking you with machine guns. As an older gamer I feel sorry for the younger generation who have never experienced real gameplay. If this game is supposed to be one of the best there is, it is a sorry state of gaming indeed.


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January 10-11, 2015 BVFF Western Idaho Fly Fishing Expo, Expo Idaho in Boise, Idaho, http://www.bvffexpo.com/
January 31, 2015 IFFF North Coast Fly Fisher's Northern Ohio Fly Fishing Expo Cuyahoga Career Center, Brecksville, Ohio. http://www.ncff.net/
January 31, 2015, FlyBuy, Long Beach Casting Club. Contact Michael Schweit 818-601-9702
February 7, 2015, Greater Cincinnati Fly Fishing Show by Buckeye United Fly Fishers, Oasis Conference Center, Loveland OH http://www.buckeyeflyfishers.com
February 28-March1, 2015 Chesapeake Council's Learning Center at the Fly Fishing Show Lancaster PA. Contact: Ken Tidy email@example.com
March 4-8, 2015, Visit the SWC at Fred Hall Show, Long Beach Convention Center, www.SWC-FFF.org
March 13 & 14, 2015 Oregon Council's 2015 Fly Tyer Expo in Albany, Oregon , www.nwexpo.com
March 20-21, 2015 The North Idaho Fly Fishing Expo, Clearwater River Event Center, Lewiston, ID www.niffe.org
May 1 & 2, 2015 Washington Fly Fishing Fair, Ellensburg, WA http://www.washingtoncouncilfff.org
May 30, 2015 Chesapeake Council Learning Day for Families, Isaak Walton League, Pylesville MD, email@example.com
August 11-15, 2015 50th Anniversary of the International Federation of Fly Fishers, Bend OR, www.fedflyfishers.org/FlyFishingFair.aspx or firstname.lastname@example.com
Event: North Idaho Flycasters Benefit, Auction & Dinner
When: April 27, 2013
Sponsored by: North Idaho Fly Casters
Website: http://www.northidahoflycasters.org


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Lightweight Travel Hip Pack
In Stock Product Number: 30317
The Patagonia Lightweight Travel Hip Pack is like a toolbox for life's little indispensables. This lightweight, stuffable hip pack keeps everything you need for a day of discovery within reach. The main pocket holds larger items like sunglasses and a point-and-shoot camera; it has a secure pocket inside for valuables and a passport. The zippered exterior pocket provides quick access to lip balm, a subway pass and a map. An internal key clip secures your hostel key, and the soft, flexible webbing belt lets you carry the pack around your hips or off-the-shoulder, bandolier style. Stows into its own pocket when not in use. Made from 1.8-oz 40-denier 100% nylon double ripstop with a polyurethane coating and a silicone finish. Reinforced with 6.3-oz 210-denier 100% nylon double ripstop that has a polyurethane coating.
* This product does not qualify for shipping to all countries.
- Main zippered compartment has zippered security pocket, which doubles as a stuff pocket when hip pack is not in use, and a key clip
- Soft herringbone webbing lets you carry hip pack comfortably on the hips or bandolier style
- Body: 1.8-oz 40-denier nylon double-ripstop with a polyurethane coating and silicone finish. Base: 6.3-oz 210-denier nylon double-ripstop with a polyurethane coating
Gender: Unisex
Weight: (6.6 oz) 187 g
Volume: 5 L / 305 cu in
Season: F14
Vendor ProductId: 48450
Review ProductId: 30317


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April 1, 2013 at 6pm to September 30, 2013 at 7pm – Kauai Hawaii Aloha, E Komo Mai Welcome to the first chocolate club of Hawaiian chocolate. We now have started a chocolate club where you will receive 4 one ounce bars a month. The 4 bars will be from a wide… Created by Koa Kahili | Type: chocolate, of, the, month, club
July 1, 2013 to July 31, 2013 – USA The Good Food Awards is excited to announce the launch of its fourth year with a call for entries July 1-31! The Good Food Merchants Guild invites food producers from across the country to submit the… Created by Clay Gordon | Type: competition, festival
© 2014 Created by Clay Gordon.


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Laptops: At home. At office. Everywhere. On-the-go
Laptops have certainly changed the way we worked. In the past few years, laptops have evolved too. Their functions, performance, size and capacity have changed radically. Nowadays, these come loaded with entertainment features such as HD viewing experience, splendid graphics, gaming support and Bluetooth. The performance features have been enhanced as well to meet computing and multimedia requirements. There are 2-in-1 laptops too which can be converted to tablet for easier viewing and handling.
Best Laptops. Best Prices in India.
Snapdeal brings you the best deals on laptops online. Your one-stop destination to find best budget laptops in India, Snapdeal offers you huge discounts. You can view complete information and compare the laptop models. If you want detailed information about a laptop model, you can use the 'know more' feature to make an informed decision about the purchase. Moreover, you can also compare laptops up against each other for technical specifications, prices and availability. You can also scroll down the product pages for authentic laptop reviews. Shopping online at Snapdeal in accordance with laptop price in India is relatively easy. Sort out laptop brands for prices and find various search results for laptops under 30000, laptops under 25000 and so on. Now you can get the best laptop under 20000 as well. Acer brand launches Acer C720 Chromebook which has great technical specification.
Why choose Snapdeal?
At Snapdeal, best laptop brand meets best laptop prices. Browse through this exclusive range of laptops online for best deals from Dell, Lenovo, Acer, HP, Mac, Sony and many more. For huge discounts, EMI offers and option of free shipping of laptops in India, there is no place better than Snapdeal! Every purchase at Snapdeal is covered under TrustPay and 7-day easy return entitling you of 100% money back guarantee. It also ensures that every product listed on the website is 100% authentic and the brand which it claims to be.


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Honeywell ST 3000 Series 900 Differential Pressure Transmitters Provice Repeatable Flow Measurement
- Category: Measurement & Sensing
- Product Type: Pressure
- Manufacturer: Honeywell Process Solutions
ST 3000 Series 900 differential pressure transmitters bring proven, smart technology to pressure measurement applications from furnace combustion airflow rate to hydrostatic tank gauging. They can be used with any primary flow element to provide repeatable flow measurement and offer greater turndown ratio than conventional transmitters. They can be used in hazardous environments.


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Keeping it Fresh with Listerine
Our bloggers include LISTERINE Antiseptic in their regular oral health routine. See why and get a chance to win $100. Read more
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Kraft Desserts
Create these wonderful dessert recipes made with Kraft products for the holidays. Your family will enjoy them! Read more
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Bienvenido a Vincci Granada!
This stunning Granada hotel is a perfect choice for visitors looking for quality of service, excellent locations and modern facilities as well as design that respects the local environment.
The Vincci Granada Hotel is located on the Avenida de la Constitucion, one of the main thoroughfares in town. This delightful 4 star hotel prides itself on guaranteeing an attention to detail that will ensure an unforgettable stay for their valued guests.
Granada is renowned world-wide as the site of some of the most impressive examples of Moorish art, monuments and structures.
The military fort of The Alhambra, which began construction in the 13th century is the best-know Arab construction in the world.
Gardens were later added that have successfully added to the opulence and grandeur of the complex, making it a real treat for sight-seers.
The Moorish quarter of Albayzin has been declared a UNESCO heritage site and represents the true soul of Granada town, maze-like streets with beautifully crafted stone buildings overlooking the majesty of the Alhambra itself.


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New Arrivals
mouse over photo to zoom click for larger image
Arria Chandelier Clip Earring
Mixed-metal medallions show off tribal style with a geo-patterned corrugated finish.
- Metal.
- Clip-on styling.
We're so sorry: this item sold out sooner than expected. For an equally chic substitute, please call our Personal Service Associates at 1.888.855.4986. Or click on Chico's Chat below for immediate assistance.


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Black Friday Shopping Tips
It takes quick decision-making to get the best deals on Black Friday. Here, advice from experts at the Good Housekeeping Research Institute (GHRI) on exactly what to look for so you can get in and out of the store — plus a few of our favorite picks. For more great product recommendations, be sure to check out our top Black Friday sale picks
By Nicole Price Fasig
Sewing Machines
- You don't need to spend thousands of dollars to get a good machine; most models will get the job done. Price differences come into play more when it comes to ease of use, high-end automatic features, and getting the right tension for a specific fabric.
- Look to see what accessories come standard with the machine. It may make a huge price difference if you need to buy a lot of extras after the fact.
- Consider what features you'll be using. Is top speed a priority, or maybe automatic needle threading? Many sewing machines come with a lot of features and functions, so figure out which ones are relevant to you.
- If you're familiar with one brand of sewing machine, you'll most likely be familiar with a different model of the same brand — most companies stick to similar threading, bobbing winding, and controls across all their models.
Our favorite sale sewing machines: Brother SQ-9000 ($199), Singer 4411 Heavy Duty Sewing Machine ($230), Husqvarna Viking Emerald 116 ($400).


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John C. Goodman on Stossel
Recorded: Thursday, June 21, 2012
Research Fellow John C. Goodman, author of Priceless: Curing the Healthcare Crisis, joins a panel on Stossel to speak on today's healthcare issues.
Experts: John C. Goodman, John StosselType: TelevisionIssues: Free Market Economics, Health Care, Public Health/ Consumer Protection
John Stossel: Why Government FailsBut Free Individuals Succeed
Recorded: Thursday, April 19, 2012
Part 1 |
Part 2
John Stossel of Fox Business Network speaks about his new book, No, They Cant: Why Government FailsBut Individuals Succeed.
Experts: John StosselType: Independent Institute EventIssues: Culture/ Society, Free Market Economics, Freedom, Government Power, Government Waste/Pork
Michael Crichton on States of Fear: Science or Politics?
Recorded: Tuesday, November 15, 2005
The late Michael Crichton, author of Jurassic Park and State of Fear, along with a panel of distinguished scientists, examine the increasing politicization of science.
Buy this event on DVD
Experts: Sallie Louise Baliunas, Michael Crichton, William M. Gray, George H. TaylorType: Independent Institute EventIssues: Energy, Environment, Science, Technology


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Sound Reel (previously Adamantium Studios) is a full service recording studio specialized in composing music for film and games.
We produce and compose music for movies, games and other medias. No matter what your needs are - classic, electronic or rock - our four talented composers can create music and soundscapes exactly for your needs.


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CENTRAL CITY, Ky. (4/12/13) – The "Fight like a Foster" Benefit 5k walk/run will be held this Saturday, April 13th, at the Central City Convention Center.
Check-in begins at 8am. Starting time is 9 am.
All proceeds go to benefit 12 year old Tyler Foster as he battles osteosarcoma, a rare bone cancer. The first 25 participants to register receive a free t-shirt.
Lindsay Ward of the Central City Convention Center said "We are inspired and humbled to host this event to help this courageous young man and his family in this battle. For the community to come together, I think it says a lot that so many can come together to show their support."
Find out more about the event by contacting Tammy Piper or Lindsey Ward at the convention center for more details at 270-757-1723.
Paul McRee
SurfKY News
Photo provided by Fight Like a Foster
© Copyright 2014 SurfKY News Group, Inc. All rights reserved. This material may not be published, broadcast, or rewritten without permission. SurfKY News encourages you to share this story by using one of the social media links below.
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Nanoscience and nanotechnology have been referred to as the Industrial Revolution of the 21st century. Nanoscience refers to the scientific phenomena that occur at sizes around a nanometer, which is one billionth of a meter. An example of scale is the walls of cells, which are five nanometers thick. Demand for graduates in nanotechnology has been increasing steadily, but currently, only a few universities offer degree programs. UNM's interdisciplinary Nanoscience and Microsystems degree program is offered jointly by the College of Arts and Sciences and the School of Engineering, evolving from the traditional disciplines of solid state physics, chemistry, biology, materials science and engineering. More than 70 faculty in nine academic departments worked together to develop the Nanoscience and Microsystems degree program. This program is a great example of how our faculty's leading-edge research benefits graduate as well as undergraduate students in a formal curriculum.
October 3, 2014: Amber completed her PhD in the Nanoscience and Microsystems Engineering program in August 2014. Her primary research mentor was Pavan Muttil in Pharmacy. She will shortly move to a postdoctoral position at Sandia National Laboratories.
October 1, 2014: NSMS student Matt Graus was awarded a one year Careers in Immunology Fellowship from the American Association of Immunologists. The program was launched in April, 2014 and supplies regular AAI members with one year of salary support for a graduate student or postdoctoral fellow. View more information about this year's recipients »
September 25, 2014: A research discovery was born from great frustration when Eric Peterson, a graduate student in Nanoscience and Microsystems Engineering at UNM, set out to learn a new measuring technique four years ago as part of his Ph.D. Read the full text of "Researchers discover catalytic converter breakthrough in automobiles" »


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This page contains Cheats for Love Gift Shooter HD organized by sections for iPad. Love Gift Shooter HD is a Miscellaneous Puzzle General game, made by Loyalmoonlight, released on Oct 9, 2013 and published by Loyalmoonlight. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
- Developer:
Love Gift Shooter HD iPad CheatsLoyalmoonlight
- Publisher: Loyalmoonlight
- Genre: Miscellaneous Puzzle General
- Release Date: Oct 9, 2013
- ESRB: Not Set
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an Love Gift Shooter HD expert then please try to help others with their questions.
Don't forget to Bookmark this page for the latest Love Gift Shooter HD Cheats. At this moment there are no cheats or walkthroughs available for Love Gift Shooter HD. If you know cheats, secrets, hints or glitches for this game then please Submit them.Submit Cheats
Doodle Fit 2: Around The World - Gameplay Review Trailer
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- Munin - Official Launch Trailer, (iPad)


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CENTRAL NEW YORK -- Two campaigns are launched to celebrate Dunkin Donuts' history in Syracuse and to help save lives.
The store launched a "Celebrate 81" campaign Friday as a way to celebrate its first store in Syracuse in 1981. Customers can expect to find promotions like an 81 cent coffee along with contests this month in the Syracuse area.
In addition, the annual "Give a Pint, Get a Pound" campaign encourages blood donations during the month of January. All blood donors will receive a coupon for a free pound of coffee.
"It's very important to give back to the community and we look forward to doing it every year. And, it's very special for us to be part of this great program," said Lane Rodgers, Dunkin' Brands Operations Director.
"They've donated 435,000 pounds of coffee which has potentially impacted one point three million patients both in Central New York and across the northeast so it's a significant impact that Dunkin' is making," said Maureen Wellman, American Red Cross Communications Manager.
All blood donors in Central New York this month are also eligible to win 81 pounds of coffee.
Dunkin' will soon be opening its 81st restaurant in the Syracuse area.
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Comes in its box. What a great gift!The Indian Head Nickel coin was designed in the early 20th century to honor the proud heritage of Native Americans and the spirit of the American West. Minted only from 1913 to 1938, this favorite among coin collectors...More info Email a friend
BUYING UNITED STATES COINS, CURRENCY, STAMPS, COMIC BOOKS & COLLECTIBLES at the highest prices. Call us for great service and prices. 305-505-1842More info Email a friend
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- Mobile Phones
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We were unable to find an exact match for the model you entered.
Based on your entry it appears that you may have one of the models listed below. Please be aware that information for similar products may not be fully applicable to your model.


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Tested by the Good Housekeeping Research Institute
Raintec 5-Section Micro Mini #602 Umbrella
Product Review
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Good Housekeeping Research Institute (GHRI) ratings are based on laboratory tests conducted by our scientists at the U.S.'s foremost consumer products evaluation laboratory, and incorporate consumer feedback. GHRI is situated on the 29th floor of the Hearst Tower in New York City and is staffed by chemists, engineers, nutritionists, textile specialists, culinary experts, and other scientists.
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This Raintec doesn't weigh much and is easy to stash in a bag or glove compartment. And while it may not weather a heavy windstorm, it should get you through a gentle shower or quick walk from the car to the house. A 38-inch span offers enough protection for one person. The plastic handle, however, may be tough to grip in wet weather. Folds down to a petite 5 inches and weighs 0.45 pounds. In black, red, green, blue, fuchsia, and lavender. raintecumbrella.com
Manufacturer's warranty: Raintec will exchange defective umbrellas within 15 days of purchase; consumers pay all shipping costs.
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Click on term to view description.
- adenine (A)
- One of the four types of base that spells out our DNA code. When a base is attached to a phosphate and sugar, it makes up a nucleotide, one of DNA's 'building blocks'. In the double-helical structure of DNA, A (adenine) pairs with T (thymine). A is also present in RNA.
See also: base, DNA, thymine (T)
- amino acid (AA)
- The components or building blocks of protein. There are twenty different amino acids that join together in long chains to make proteins. These are (with 3 letter and 1 letter abbreviations in brackets): alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), Glutamine (Gln, Q), Glycine (Gly, G), Histidine (His, H), Isoleucine (Ile, I), Leucine (Leu, L), Lysine (Lys, K), Methionine (Met, M), Phenylalanine (Phe, F), Proline (Pro, P), Serine (Ser, S), Threonine (Thr, T), Tryptophan (Trp, W), Tyrosine (Tyr, Y), Valine (Val, V)
See also: protein
- anticodon
- A sequence of three unpaired nucleotides or bases on an 'adaptor' transfer RNA (tRNA) molecule. The anticodon can bind, following the rules of base pairing, to a triplet of nucleotides (a codon) in a messenger RNA (mRNA) molecule.
See also: codon, complementary, base, base pair
- bacterial artificial chromosome (BAC)
- A length of DNA with sequences that allow it to be maintained and reproduced in bacteria. DNA libraries for genome sequencing can be made using BACs: the DNA of interest is inserted into the BAC, and the package is taken up by bacteria. As the bacteria grow and divide, the BAC and the DNA of interest is also copied. BACs were the cornerstone of sequencing the human genome; at the time, they could hold 100,000 - 200,000 base pairs of DNA (100-200 kb); now they can hold double or triple that amount.
See also: DNA, sequencing
- base
- The basic unit of our genetic instructions: DNA instructions are encoded in the sequence of its chemical 'letters' or bases. There are four bases: adenine(A), cytosine(C), guanine (G) and thymine (T). Another base, uracil (U) replaces T in RNA.
See also: base pair, cytosine (C), adenine (A), guanine (G), thymine (T), uracil (U), DNA, RNA
- base pair (bp)
- Two bases on opposite strands of a DNA molecule that are held together by weak chemical bonds. In DNA's double helical structure, a base pair forms one 'rung' of the DNA 'ladder'. The rules of base pairing are that A always binds to T and C always binds to G. The bp is also the measurement unit of DNA; the human genome contains more than 3,000,000,000 bp. 1,000 bp = 1 kilobase pair and 1,000,000 bp make up 1 megabase pair. The word 'pair' is often dropped when referring to the genome sequence of an organism; a bacterium could be said to have 4.09 Mb (megabases) in its genome.
See also: base, DNA, RNA
- bioinformatics
- The science of using computer technology to gather, store, analyse and merge biological data. Expertise in bioinformatics is key to handling the enormous amounts of data produced by the Human Genome Project and other sequencing projects, and serving it out to the researchers who use the data. Advances in computer research are as important as the biology for such large scale projects.
- catalyst
- A chemical that initiates or accelerates a chemical reaction. A biological catalyst is an enzyme (usually a protein) with active regions which bind the components of a reaction.
See also: enzyme
- cell
- The basic component of living things. Our bodies are made up from about 100 million million cells. In humans and other complex organisms, these watery bodies contain a range of chemicals, individual components called organelles and copies of the organism's genome.
See also: nucleus, cytoplasm
- chromosome
- A threadlike structure in our cells, made of a long DNA molecule, wrapped around a protein scaffold. Other organisms also have chromosomes: most bacterial chromosomes are loops or circles of DNA. The smallest human chromosome has around 50 million DNA letters and the largest has more than 240 million.
See also: DNA, RNA
- clone
- An exact copy of something. In sequencing work, this refers to copying molecules, such as DNA, rather than whole cells or organisms. Small pieces of DNA are stitched into carrier molecules (vectors) that can be copied in bacteria or cells. This means that many copies can be made of any DNA segment as the bacteria grow and divide. Each unique combination is called a clone.
- codon
- A sequence of three DNA bases that specifies one amino acid (building block) of a protein. The DNA code for proteins is written in 'words' of three letters. Four DNA letters provide 64 different combinations of 3 letter words; 61 of the 64 possible combinations code for an amino acid. The 'start codon' signals the beginning of amino acid chain production beginning with methionine (Met). The 'stop codon' signals the end of the assembly of amino acids. There are three different codons which can act as 'stop codons'.
See also: base, amino acid
- complementary
- The preferential binding of bases A to T (or U) in DNA or RNA. For example, if there is a GTC on the DNA strand, the complementary RNA or DNA sequence will be CAG. This complementarity maintains the double helical structure of DNA, and makes cellular processes such as transcription (when an RNA copy is made of a DNA strand) or replication (where complementary copies of the existing DNA strands are made).
See also: base, DNA, RNA
- copy number variation (CNV)
- Copy number variation refers to differences in the number of copies of a particular DNA segment between two or more genomes. Variations in copy number have been found within individuals, between individuals and between humans and other mammals. CNVs can result from simple duplications of DNA segments or may involve complex gains or losses of similar sequences at many sites in the genome.
- cystic fibrosis (CF)
- An inherited disorder that makes it hard to breathe and digest food. CF is caused by mutations in a gene called the cystic fibrosis transmembrane conductance regulator (CFTR); a thick, sticky mucus clogs the lungs and digestive system of people with the faulty gene. In the UK, 1 in 2500 people have CF and although there is no cure, physiotherapy, medication and exercise allow most to live 30-40 years.� CF is a recessive disorder: if a person has only one faulty copy of the gene, they are said to be a 'carrier'; if they have two faulty copies, they will have CF. All newborn babies in the UK are screened for CF, and a mouthwash test can show whether you are a carrier. The name cystic fibrosis refers to the characteristic 'fibrosis' (tissue scarring) and cyst formation within the pancreas, first recognized in the 1930s.
See also: CFTR
- cystic fibrosis transmembrane conductance regulator (CFTR)
- The product of the CFTR gene is a chloride ion channel important in creating sweat, digestive juices, and mucus. Alterations or mutations in the gene can responsible for causing the inherited disorder cystic fibrosis (CF). In CF, the ion channel is not working properly, leading to a water-shortage outside of the cells and a thick, sticky mucus which fails to move bacteria away, often resulting in infection and inflammation of the lungs. People with CF have two working copies of the CFTR gene, only one is needed to prevent cystic fibrosis. CF develops when neither gene works normally. Therefore, CF is considered an autosomal recessive disorder.
See also: cystic fibrosis
- cytoplasm
- The fluid-filled area of the cell in animals, plants and fungi that surrounds the nucleus and acts as the factory-floor of the cell. Instructions from the DNA and messages from outside the cell are interpreted by molecules in the cytoplasm.
See also: cell, nucleus
- cytosine (C)
- One of the four types of 'base' that spells out our DNA code. When a base is attached to a phosphate and sugar, it makes up a nucleotide, one of DNA's 'building blocks'. In the double-helical structure of DNA, C (cytosine) pairs with G (guanine). A is also present in RNA.
See also: base, DNA, guanine (G)
- deoxyribonucleic acid (DNA)
- The long molecule that encodes our genetic instructions. Two strands of DNA are twisted together into the double helix. The base-pairs between A and T and between C and G hold the two strands together. In our cells, DNA is usually packaged into chromosomes.
See also: base pair, helix, chromosome
- diabetes
- Diabetes mellitus is a metabolic disorder of the pancreas being unable to produce sufficient insulin (a hormone that regulates carbohydrate metabolism) to maintain a healthy level of blood sugar. This results in hyperglycaemia (high blood sugar) which can cause increased risk of heart disease, chronic kidney failure, blindness, nerve damage and damage to blood vessels.
See also: insulin
- dominant
- The 'stronger' version of a pair: this type of gene or characteristic will appear or be 'expressed' even if there is only one copy.
See also: recessive
- Down's syndrome
- Down's syndrome (Down syndrome or trisomy 21) is a genetic condition caused by the presence of all or part of an extra chromosome 21. It is named after John Langdon Down, a British doctor who described it in 1866. Often Down's syndrome is associated with delays in or impairment of learning and physical development as well as a distinctive facial appearance.
See also: chromosome
- egg
- A female reproductive cell. Also called an ovum. Combines with male reproductive cell (sperm) during fertilisation.
See also: sperm, fertilisation
- enzyme
- An enzyme is usually a protein (although some exceptions are made from RNA) that can initiate, facilitate or speed up a reaction. Enzymes have a variety of functions in the body, including digesting food, transmitting nerve impulses and making our muscles work.
See also: polymerase, catalyst
- exon
- The part of a gene that has the instructions to make a protein.
See also: intron
- expression
- Process of making molecules from the instructions in DNA. The amount of RNA and protein produced from a gene is referred to as its level of expression.
- fertilisation
- Union of egg and sperm in the creation of a new being of the same species.
See also: egg, sperm
- fingerprinting
- A method that detects the variation in DNA sequence between individuals. Short, variable sequences in the DNA are reproduced and their sizes are compared. The differences are seen as bands on a gel.
See also: DNA, gel electrophoresis, polymerase chain reaction
- gel electrophoresis
- A technique which uses a thin block of jelly-like material (gel) to act as a sieve to separate molecules. Fragments of DNA or proteins are separated based on their size by applying an electrical field across the gel. The smaller molecules move more quickly than the larger molecules.
See also: fingerprinting
- gene
- A sequence of DNA that carries the information required to make a molecule, usually a protein. It includes sequences that define the beginning and end of the protein (start and stop codons) and signals that control when the protein should be made. In humans and other complex organisms, genes are split into coding (exons) and non-coding sequences (introns). These split sections allow some genes to make more than one type of protein.
See also: DNA
- genetic code
- The genetic code is written in 'words' of three letters in DNA (such as ATG, CCG, TAA and so on). This code must be 'transcribed' and then 'translated' by the cell into the building blocks of molecules such as proteins. Other parts of the code are 'switches' to turn genes on or off, or to increase or decrease the amount of protein produced.
See also: codon
- genome
- A copy of all the DNA instructions used to make an organism. Our genome is approximately 3,000,000,000 base-pairs or genetic letters; most of our cells carry two copies of our genome, packaged into 23 pairs of chromosomes. The genomes of some plants are five times bigger than ours, while some bacteria have only 1,500,000 base-pairs in one chromosome.
See also: base pair, chromosome
- guanine (G)
- One of the four types of 'base' that spells out our DNA code. When a base is attached to a phosphate and sugar, it makes up a nucleotide, one of DNA's 'building blocks'. In the double-helical structure of DNA, G (guanine) pairs with C (cytosine). G is also present in RNA.
See also: base, DNA, cytosine (C)
- haemoglobin (Hb)
- Protein which carries oxygen in the blood.
See also: sickle cell anaemia
- haemophilia
- A genetic disorder that reduces the ability of a person's blood to clot and can result in uncontrolled bleeding. Haemophilia usually occurs in males and less often in females as the genes mutated in the two forms of haemophilia are on the X chromosome.
- helix
- Twisted shape in the form of a spiral, coil or screw. Can turn to right (clockwise) or left (anticlockwise), referred to as an alpha helix or a beta helix, respectively. DNA has an alpha-helical (right-turning) structure.
See also: DNA
- homology
- In genetics, when two or more DNA sequences are highly similar.
- human immunodeficiency virus (HIV)
- Human immunodeficiency virus (HIV) is a retrovirus that can lead to acquired immunodeficiency syndrome (AIDS, a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections).
- Huntington's Disease
- A progressive neurological disorder that causes uncontrollable muscle spasms. Also known as Huntington's chorea. Huntington's disease is caused by multiple 3-letter repeats within the huntingtin (HD) gene. This expansion produces an altered form of the Htt protein, mutant Huntingtin (mHtt), which results in neuronal cell death in select areas of the brain.
- hypertension
- Condition of high blood pressure. Usually refers to arterial hypertension. Hypertension has been associated with a higher risk of heart attack or stroke.
- insulin
- A small protein hormone that regulates glucose levels in the body. Insulin is secreted by the pancreas and stimulates cells to take up glucose from the blood for use in energy production.
See also: diabetes
- intron
- Part of a gene that is not used to make protein and is cut out from from the RNA between transcription and translation.
See also: exon
- inversion
- An inversion is a chromosome rearrangement in which a segment of a chromosome is reversed end to end. An inversion occurs when a single chromosome breaks and rearranges itself. If there's no missing or extra genetic information, inversions usually don't affect the cell or the organism.
- junk
- 'Junk' DNA refers to sequence regions of DNA without known function, that is, it does not contain instructions for making proteins. About 97% of the human genome has previously been designated as "junk". As researchers find out more about the function of this DNA, it is now more appropriately referred to as "noncoding DNA".
- kilobase (kb)
- One thousand bases, or pairs of bases (1000 b or 1000 bp). In molecular biology, commonly used to describe the length of a DNA/RNA molecule. A Mb (megabase) is one million bases and Gb (gigabase) is one thousand million bases.
See also: megabase, base pair, nucleotide
- leukaemia
- A cancer of the blood or bone marrow. Leukaemia, like other cancers, result from changes to the DNA which activate cancer-causing cells or deactivate cancer-suppressing cells. These changes may occur spontaneously or as a result of exposure to radiation or carcinogenic substances and can be influenced by genetic factors. Studies have linked exposure to petrochemicals, such as benzene, and hair dyes to the development of some forms of leukaemia.
- library
- In molecular biology, a collection of isolated DNA sequences is called a library (or bank). The DNA sequences are often held in bacteria, which serve as factories to store and make copies of the DNA.
See also: bac
- malaria
- Malaria is one of the most common infectious diseases and a global public-health challenge. The disease is caused by protozoan parasites of the genus Plasmodium. Malaria parasites are transmitted by female Anopheles mosquitoes. The parasites multiply within red blood cells, causing symptoms that include symptoms of anaemia (light headedness, shortness of breath, racing heartbeat), as well as other general symptoms such as fever, chills, nausea, flu-like illness, and in severe cases, coma and death.
- mapping
- Biologists identify specific sequences or 'landmarks' on chromosomes or the DNA they contain. These may be visible landmarks based on pictures of chromosomes that have been stained to show 'stripes', or landmarks based on DNA sequences that can be detected using fluorescent markers. The maps help us to work out where a particular DNA sequence of interest is located.
See also: sequencing
- megabase (Mb)
- One million bases or base pairs (1,000,000 b or 1,000,000 bp). In molecular biology, commonly used to describe the length of a DNA/RNA molecule. A Mb (megabase) is one million bases and Gb (gigabase) is one thousand million bases.
See also: kilobase, nucleotide
- messenger RNA (mRNA)
- A single stranded molecule that acts as the template for protein assembly. When a protein is made, the DNA instructions are transcribed into messenger RNA (mRNA). The mRNA then moves out of the cell's nucleus to be read by molecular machines (called ribosomes) that assemble the protein. The product is a chain of protein building blocks (amino acids) that have been assembled according to the order of the bases along the RNA. In animals and plants, the mRNA copy is also 'edited' to remove sequences that won't become part of the protein (see intron).
See also: nucleus, cell, ribosome, amino acid, protein
- mutation
- A change in DNA sequence. Mutations are relatively common in our DNA, but most have no detectable effect.
- nucleic acid
- A complex molecule found in all living cells and viruses. Nucleic acids, in the form of DNA or RNA, carry the genetic information to make an organism, which is passed between generations.
See also: DNA, RNA
- nucleotide (nt)
- A nucleotide is a base, such as, adenine, guanine, cytosine or thymine, attached to a sugar and one or more phosphate groups. These are the 'building blocks' of DNA and RNA.
See also: base
- nucleus
- The central subcompartment of a cell that contains genetic information.
See also: cell, cytoplasm
- pharmacogenetics
- Studying an individual's genetic make up in order to predict responses to a drug and guide prescription.
See also: pharmacogenomics
- pharmacogenomics
- Analysing entire genomes, across groups of individuals, to identify the genetic factors influencing responses to a drug.
See also: pharmacogenetics
- polymerase
- DNA polymerase is the enzyme that makes new copies of DNA from a template strand and available nucleotides. RNA polymerase is the enzyme that makes an RNA copy of a DNA strand during transcription.
- polymerase chain reaction (PCR)
- A technique to make large quantities of a specific fragment of DNA. It is often used in DNA testing and fingerprinting to amplify small amounts of DNA so that scientists have enough to work with. Used in DNA profiling, testing and in some sequencing work.
See also: fingerprinting, sequencing
- polypeptide
- A protein is made from one or more chains of amino acids, known as polypeptides. Peptide bonds describe the links between amino acids as they are assembled to form a poly (meaning multiple) peptide.
See also: aminoacid, protein
- protein
- A molecule made from chains of amino acid building blocks, the order of which is coded in DNA. The order of amino acids is different for different proteins - the sequence determines properties of the protein. Major proteins include keratin which makes hair and nails, actin and myosin which make muscle, globin which carries oxygen and makes blood red, and antibodies which protect us from disease.
See also: aminoacid, ribosome
- radioactive
- A substance emitting ionizing radiation is said to be radioactive. This form of radiation can penetrate cells and create ions in the cell contents. These, in turn, can cause permanent alterations/mutations in DNA.
See also: x-ray, mutation
- recessive
- The 'weaker' one of a pair. A recessive disorder will only appear if two copies of the mutated gene are inherited. Otherwise, the characteristic encoded by this gene is overwhelmed by a dominant gene.
See also: dominant
- ribonucleic acid (RNA)
- Ribonucleic acid (RNA) is composed of nucleotides, as is DNA, but its structure is a single strand not double. In transcription, a transportable copy of the code for a particular molecule or protein is produced, called messenger RNA. This means the code can move from the nucleus to other regions of the cell where the protein assembly occurs. RNA exists in different forms, including mRNA (messenger RNA), tRNA (transfer RNA) and ribosomal RNA (rRNA).
See also: base, codon, messenger RNA (mRNA), transfer RNA (tRNA)
- ribosome
- Protein-making factory of the cell. Made of protein and RNA, ribosomes coordinate the reading of the mRNA template. They add new amino acids to the translated protein chain according to the nucleotide sequence of the mRNA.
See also: aminoacid, protein
- rough endoplasmic reticulum (RER)
- Subcellular structure in the cytoplasm of a cell where proteins destined for export are assembled.
See also: cell
- sequencing
- The method of determining the order of letters or bases in DNA, or the order of amino acids in a protein molecule.
See also: base, codon, DNA, RNA
- sickle cell anaemia
- A blood disorder in which red blood cells can become sickle-shaped under certain conditions. This is due to a mutation in the haemoglobin protein which is responsible for binding oxygen. The condition is a recessive genetic disorder meaning one copy of the mutated gene must be inherited from each parent for the individual to have sickle cell anaemia.
See also: haemoglobin
- sperm
- Male reproductive cell. Combines with a female reproductive cell (ovum) during fertilisation.
See also: fertilisation, egg
- thymine (T)
- One of the four types of 'base' that spells out our DNA code. When a base is attached to a phosphate and sugar, it makes up a nucleotide, one of DNA's 'building blocks'. In the double-helical structure of DNA, T (thymine) pairs with A (adenine).
See also: base, DNA, adenine (A)
- transcription
- The process of making a complementary (RNA) copy of a region of DNA. As in writing, transcription is essentially the copying of a string of text; in the cell, the information is copied into a form that can act in various ways. Some RNA copies -- of sections of DNA that encode proteins -- move out of the cell's nucleus to be translated. Other RNA copies -- non-coding RNAs -- can act directly on other parts of the DNA or become part of the protein-translation machinery.
See also: complementary, RNA, DNA
- transfer RNA (tRNA)
- Transfer RNA is a small RNA chain (73-93 nucleotides). It acts as a kind of 'adaptor molecule' during translation. Three RNA bases (the anticodon) of tRNA binds to a complementary sequence on the messenger RNA template to deliver a new amino acid to add to the growing polypeptide chain. Each type of tRNA molecule can be attached to only one type of amino acid.
See also: RNA, translation
- translation
- The process of turning the sequence of bases in a messenger RNA (mRNA) molecule into a protein. In a cell, translation occurs at structures called ribosomes in the cell's cytoplasm. There, the mRNA is read by 'adaptor molecules' called transfer RNAs (tRNAs) and amino acids are assembled according to the sequence of bases in mRNA.
See also: base, RNA, DNA, ribosome, messenger RNA (mRNA), transfer RNA (tRNA)
- translocation
- A chromosome translocation is a mutation caused by rearrangement of parts between different chromosomes.
See also: mutation
- uracil (U)
- One of the four types of 'base' used to encode information in RNA. When a base is attached to a phosphate and sugar, it makes up a nucleotide, one of RNA's (and DNA's) 'building blocks'. RNA uses the three standard bases of A, C, G, but substitutes U for T. When RNA is bound to DNA, U (uracil) pairs with A (adenine).
See also: base, RNA, thymine (T)
- virus
- Infectious particle containing DNA or RNA and sometimes a protein coat. Generally not considered a living organism as it requires infection into another organisms living cells to replicate.
- x-ray
- X-rays are a form of ionizing radiation primarily used for radiography and crystallography. They are a form of electromagnetic radiation with a wavelength in the range of 10 to 0.01 nanometers, corresponding to frequencies in the range 30 to 30 000 PHz (1 PHz = 1015 Hertz).
See also: radioactive


text:
If you have spent a sleepless night, you know it can be debilitating. Most people get less sleep per night than is necessary to stay healthy and alert. However, you can get help catching those Z's. By improving your sleep hours, your waking hours should improve as well.
Doug, a teacher in his late 40's, complains of fatigue, dozing at his desk in the middle of the day, and practically falling asleep at the wheel. He admits he has never had "good sleep" and is fed up with his lack of energy and its impact on his work and social life.
Doug is one of many Americans who suffer with insomnia.
What Are the Symptoms?
Many adults complain of excessive sleepiness and tiredness during the day, and they may readily fall asleep when reading or watching TV. Other symptoms include:
- Taking a long time to fall asleep
- Trouble with memory and concentration
- Irritability
- Decreased work productivity
- Waking up fatigued, with a headache and feeling unrefreshed
- Waking up frequently and having trouble falling back to sleep
With sleep apnea, the sleep partner often reports loud snoring and pauses in breathing followed by gasping, a choking sound, or coughing. Doug's wife complains about his loud snoring, but says he does not seem to gasp or cough at night. Even so, he does not feel refreshed when he gets up in the morning and wonders if he should have it checked out. Sleep apnea may be associated with a number of chronic conditions like cardiovascular disease and high blood pressure.
What Are the Causes?
Physical Causes
Sleep apnea, often due to increased body weight, may also be due to problems with the airway, such as enlarged tonsils, or weak throat muscles. Jawbone abnormalities that impair airflow at rest, even in people who are thin, can also disrupt sleep.
Other health problems that may disrupt sleep include restless leg syndrome, gastroesophageal reflux, and chronic pain.
Taking certain medicine can also increase the risk of insomnia. Some examples include medicines used to treat high blood pressure, depression, Parkinson's disease, and thyroid disorder.
Psychological Causes
While sleep problems can be due to an underlying medical disorder, it is also important to consider a mental health condition. Psychological causes of sleep disorders include stress, depression, anxiety, and drug abuse.
Lifestyle Causes
Caffeine, alcohol, and smoking are common culprits in sleep disturbance as well. Even the habit of having a nightcap to relax in the evening can impair your sleep. While a glass of wine or beer may seem to help you sleep, the caffeine in your cup of coffee rears its head just as your blood alcohol level drops.
The same can be said for nicotine. How long you can go without a smoke after you wake up? If you cannot go more than 30 minutes, you may awaken at night with nicotine withdrawal.
Night-shift work or rotating shifts can throw off your normal sleep-wake rhythm. Working long hours and having jet lag can also lead to insomnia. A disrupted schedule often includes irregular diet and exercise, both of which are important for good rest.
How Are Sleep Problems Diagnosed?
Diagnosis of sleep problems are identified based on how you answer certain questions. Questions include:
- How long has this sleep problem lasted?
- How much has it interfered with your normal day?
- Are there any underlying problems—stress, relationship issues?
- Do you have an odd work schedule?
- Have you had recent or frequent travel?
- Are you a smoker? How heavy?
- Do you drink alcohol? How much and how often?
If your doctor suspects a serious physiological cause, such as in sleep apnea, you should be referred to a sleep specialist.
What Are the Treatments?
There are a range of treatments for insomnia. For example, if you are like Doug and are diagnosed with sleep apnea, your doctor may recommend treatments like losing weight, using a continuous positive airway pressure (CPAP) machine, or undergoing surgery. For other causes of insomnia, your doctor may recommend that you make lifestyle changes, such as improving your sleep hygiene. This involves strategies like:
- Doing relaxation therapy
- Getting regular exercise
- Having regular bed- and wake-time hours
- Keeping the bedroom dark and quiet
- Limiting alcohol and caffeine consumption
There are many other treatments to help you get a good night's rest. In some cases, medication may be prescribed to aid you in falling asleep and staying asleep through the whole night. Also, if you have an underlying condition, like depression, getting proper treatment can improve insomnia.
What Should You Do If You Have a Sleep Disorder?
As a rule, if you are not waking up as refreshed as you used to, pay attention. It is not normal to wake up tired and worn out. Will cutting back on caffeine and alcohol do the trick? Or, is something else—such as a physical problem—disrupting your sleep?
If your sleep problems persist for longer than a week and are bothersome, or if sleepiness interferes with the way you feel or function during the day, a doctor's help may be needed. To get the most out of your doctor's visit, you will find it helpful to keep a diary of your sleep habits for about 10 days to identify just how much sleep you are getting over a period of time and what you are doing that interferes with your sleep time.
- Reviewer: Michael Woods, MD
- Review Date: 06/2013 -
- Update Date: 06/12/2013 -


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Follow The Strokes
Oct 21
Check out Nikolai's interview with author Jay Griffiths on her book Wild: An Elemental Journey, published by Penguin UK, for The Rumpus.
Oct 03
Get the details at The Merch Table.
Aug 25
The Strokes are set to perform at The 2011 Reading and Leeds Festivals. The band will hit the main stage at the Reading Festival on Saturday, August 27th and the Leeds Festival on Sunday, August 28th. Check out more info here. BBC Three will also be broadcasting live from the Reading Festival at 10 PM GMT. Tune in.
Aug 23
Happy Birthday, Julian!
Aug 04
The Strokes will be performing at Summer Sonic in Tokyo, Japan on August 13th and in Osaka, Japan on August 14th. Check out more details on The Strokes Events page.
Jul 29
Now Playing @6Music's topic is The Strokes in celebration of the 10th Anniversary of Is This It Visit the BBC 6 Music Facebook page to tell discuss all things Strokes. Add a comment or drag your favorite track into their Spotify list - http://bit.ly/ntZMXH
Jul 20
Strokes are hitting up Switzerland for The Paleo Festival Nyon on Thursday, July 21st. For more of Strokes' upcoming festivals, click here.
Jul 19
Strokes will be performing at Le Zenith in Paris at Parking Pte de la Villette on Wednesday, July 20th. Are you going to the show? Strokes are also play at Paleo Festival Nyon in Switzerland on July 21st. Check out more of their upcoming events here.


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