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Immune Diseases
This page is updated frequently with new Immune Diseases-related patent applications. Subscribe to the Immune Diseases RSS feed to automatically get the update: related
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List of recent Immune Diseases-related patents
Sirt 1 activator including syringaresinol
The present invention relates to a compound of formula 1, and an sirt 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the sirt 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases..
Method for the controlled intracellular delivery of nucleic acids
The present invention relates to a method for the controlled intracellular delivery of nucleic acid molecules into one or more target cells, in particular tumor cells, the method comprising: providing a polymeric complex formed between one or more nucleic acid molecules to be delivered and one or more cationic carrier molecules, wherein at least a part of the one or more carrier molecules in the polymeric complex are covalently attached to hydroxyalkyl starch, and wherein the hydroxyalkyl starch is shielding the polymeric complex; allowing the shielded polymeric complex to get into contact with the one or more target cells; deshielding the polymeric complex by removing the hydroxyalkyl starch; and allowing the deshielded polymeric complex to internalize into the one or more target cells. Removal of the hydroxyalkyl starch can be accomplished enzymatically by exposing the polymeric complex to amylase.
Therapeutic compounds
The invention provides compounds of formula (i) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (i), processes for preparing compounds of formula (i), intermediates useful for preparing compounds of formula (i) and therapeutic methods for treating cancer or treating autoimmune diseases or preventing transplant rejection using compounds of formula (i)..
Azathioprine oral suspensions and methods of use
Compositions of azathioprine oral suspensions are disclosed. Disclosed azathioprine oral suspensions may be used to administer azathioprine to subjects such as children and geriatric patients that may have difficulty in swallowing solid dosage forms.
Novel compounds useful for the treatment of metabolic and inflammatory diseases
These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example inflammatory conditions, infectious diseases, autoimmune diseases, diseases involving impairment of immune cell functions, cardiometabolic diseases, and/or proliferative diseases.. .
Modified epitopes for boosting cd4+ t-cell responses
The present invention relates to immunogenic peptides comprising a t-cell epitope. Said peptides are modified such that cd4+ t-cell responses are obtainable that are much stronger than the cd4+ t-cell responses obtained with the same peptides not comprising said modification.
Methods for the treatment or prevention of systemic sclerosis
The invention is in the field of molecular immunology, more in particular, in the field of the prevention or treatment of autoimmune diseases, more in particular, systemic sclerosis or scleroderma. The invention is based on the observation that ssc patients have an elevated plasma level of cxcl4.
Preventive and/or ameliorative agent for diseases, stamina enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them
A purple non-sulfur bacteria useful in preventing and/or ameliorating at least one disease selected from the group consisting of inflammatory diseases, allergic diseases, and autoimmune diseases and having high safety is provided. A preventive and/or ameliorative agent is for at least one disease selected from the group consisting of inflammatory diseases, allergic diseases, and autoimmune diseases and includes at least one of a purple non-sulfur bacteria and a culture material obtained by culturing the purple non-sulfur bacteria.
Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by h4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.. .
Method of making monomethyl fumarate
Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis..
Triazolopyridine derivatives as a tyrosine kinase inhibitor
Provided is a novel triazolopyridine derivative having irreversible tyrosine kinase inhibiting activities, and a pharmaceutical composition comprising the same which can be useful for prevention or treatment of inflammatory diseases, autoimmune diseases, proliferative diseases or hyperproliferative diseases, immunologically mediated diseases, cancers or tumors.. .
Antispasmodic 1,2-diols and 1,2,3-triols
The present invention is directed to pharmaceutical compositions comprising antispasmodic c4-c8aliphatic-1,2-diols and c4-c8aliphatic-1,2,3-triols and their use to relieve the spasms associated with pain. These agents may be administered topically or orally and may be combined with anti-inflammatory agents such as a non-steroidal anti-inflammatory drug or a corticosteroid.
Method for increasing specificity of diagnostic tests for autoimmune diseases
Provided is a method for increasing the specificity of an antibody-based test to help in the diagnosis of autoimmune diseases by contacting a subject's sample with a blocking antigen prior interfering antibody present in the sample. More specifically, a method for increasing specificity of an antibody-based autoimmune disease assay comprising the steps of providing a sample from a subject, contacting the sample with a dfs70 derived antigen, reacting the sample with an autoimmune disease target and detecting antibodies to the autoimmune disease target is disclosed..
Core-shell particle formulation for delivering multiple therapeutic agents
A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, core-shell particle formulation configured to independently release therapeutic agents from the core and the shell.
Nanocell drug delivery system
Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent.
Oxidized cardiolipin as a novel pro-inflammatory factor
Low levels of antibodies reactive with oxidised cardiolipin (oxcl) in mammals are related to an increased risk of developing cardiovascular diseases, auto-immune diseases or inflammatory conditions. High levels can have a protective function and in general there is a negative association between manifestations of these conditions and antibodies against oxcl.
Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
The present invention relates to processes and intermediates useful in the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of formula (ia) and salts thereof, an s1p1 receptor modulator that is useful in the treatment of s1p1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).. .
Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine h4 receptor
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as h4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by h4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.. .
Novel urea and thiourea derivatives
The present application discloses compounds of formula (i) wherein x is ═o, ═s, ═nh, ═noh and ═no-me; a is —c(═o)—, —s(═o)2—, —c(═s)— and p(═o)(r5)—; b is, —o—, —(ch2)3-6—, and o—(ch2)2-5—; d is, —o—, —cr7r8— and —nr9; m is 0-12, n is 0-12, m+n is 1-20; p is 0-4; r1 is opt.sub. Heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof.
Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases
The invention provides modulators for the orphan nuclear receptor rorγ and methods for treating rorγ mediated diseases by administrating these novel rorγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of formula (1) and the enantiomers, diastereomers, n-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof..
Therapeutic agent for autoimmune diseases or allergy, and method for screening for the therapeutic agent
Disclosed is a therapeutic agent for treating a cellular immune disease, comprising as an active ingredient a substance that inhibits binding between sema3a and a neuropilin-1/plexin-a1 heteroreceptor. The substance includes, for example, a sema3a neutralizing antibody, a neuropilin-1 neutralizing antibody, or a soluble neuropilin-1 or derivative thereof.
Novel phytosphingosine derivatives, and composition comprising same for preventing and treating inflammatory skin diseases, autoimmune diseases, and hyperkeratosis diseases
A phytosphingosine derivative of chemical formula ia or ib, and a composition comprising the phytosphingosine derivative for preventing and treating inflammatory skin diseases, autoimmune diseases, and hyperkeratotic diseases. The phytosphingosine derivatives of the present disclosure are involved with transcription factors related to inflammation, autoimmune diseases and hyperkeratotic diseases, the expression and the generation of inflammatory mediators, signal transduction mechanisms, and the expression and the activity of relevant enzymes and the like..
Mutant hsp70i to prevent autoimmune disease
A vaccine and method of treatment suitable for treating autoimmune diseases, such as vitiligo, by using variant peptides representing a sequence of amino acids found in heat shock protein 70. The vaccine includes a peptide derived from inducible heat shock protein 70 and a plasmid containing a full inducible heat shock protein 70 dna sequence encoding the peptide..
Use of pdl1 expressing cells to convert t cells into regulatory t cells
The present invention provides methods and compositions for converting a t cell into a cell that exhibits at least one regulatory t cell phenotype. The converted t cell is generated by contacting a t cell with a cell that is modified to comprise an agent capable of activating pd1 signaling in a t cell.
Human-derived bacteria that induce proliferation or accumulation of regulatory t cells
Species of human-derived bacteria belonging to the clostridia class have been shown to induce accumulation of regulatory t cells (treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases..
Inhibitors of bruton's tyrosine kinase
Disclosed herein are pyrazolo[3,4-d]pyrimidines that form covalent bonds with bruton's tyrosine kinase (btk). Also described are irreversible inhibitors of btk.
Crystalline forms of a bruton's tyrosine kinase inhibitor
Described herein is the bruton's tyrosine kinase (btk) inhibitor 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the btk inhibitor, as well as methods of using the btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions..
Silicon-containing fumaric acid esters
The present invention is directed to silicon-containing fumaric acid esters of the formulae i-iv. The silicon-containing fumaric acid esters of formulae i-iv are useful in transplantation medicine and for the treatment of autoimmune diseases and autoimmune-related diseases.
Utility of insulin-like 6 (insl6) for the treatment of autoimmune diseases
The present invention is directed to compositions and methods to treat an autoimmune disease in a subject, comprising an insulin-like 6 (insl6) agent, such as an insl6 polypeptide or variant or fragment thereof, or a nucleic acid encoding insl6 poly peptide or variant or fragment thereof. Aspects of the present invention relate to use of insl6 agents to reduce t-regulatory (treg) cells in the subject and to reduce pro-inflammatory cytokines in a subject with an autoimmune disease such as a muscle autoimmune disease.
Immunoglobulin constant region fc receptor binding agents
Ivig replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function.
Small molecule inhibitors of stat3 with anti-tumor activity
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of stat3 signaling, stat3 dimerization, stat3-dna binding, stat5-dna binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, nsc 74859 (s31-201), nsc 42067, nsc 59263, nsc 75912, nsc 11421, nsc 91529, nsc 263435, and pharmaceutically acceptable salts and analogs of the foregoing.
Inhibitors of c-fms kinase
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
Her2/neu-specific antibodies and methods of using same
This invention relates to antibodies that specifically bind her2/neu, and particularly chimeric 4d5 antibodies to her2/neu, which have reduced glycosylation as compared to known 4d5 antibodies. The invention also relates to methods of using the 4d5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease..
Mesenchymal stem cells and uses therefor
Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, repairing epithelial damage and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.. .
Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
Which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-fms (csf-1r), c-kit, and/or pdgfr kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-fms, c-kit, or pdgfr kinases..
Materials and methods for modulating immune responses
The present invention provides nanoparticle-coupled tolerogenic treg cell therapy for treatment of immune and/or autoimmune disorders. In certain specific embodiments, the present invention can be used in the prevention and/or treatment of autoimmune diseases including, but not limited to, type 1 diabetes, lupus erythematosus (sle), multiple sclerosis (ms), inflammatory bowel disease (ibd), rheumatoid arthritis, oophoritis, and autoimmune pathology associated with graft versus host disease (gvhd) following hematopoietic stem cell transplantation..
Bi-specific antibodies for medical use
A bispecific antibody format devoid of an active fc moiety comprising a monovalent binding site for a death receptor and at least one binding site for a cell surface antigen expressed on b-cells, for use in the treatment or prevention of b cell mediated autoimmune diseases.. .
Il-12 p40 monomer, monoclonal antibody against p40 homodimer and the combination of the two for autoimmune disease treatment
A novel approach to discover new drugs against ms and other autoimmune diseases is disclosed. The p40 family of cytokines has four members which include interleukin-12 (il-12), the p40 monomer (p40), the p40 homodimer (p402), and the il-23.
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Maruti to pay royalty to Suzuki in Rupees for future modelsThe country's largest car maker Maruti Suzuki India Ltd. will pay royalty on its future models to parent Suzuki Motor Corp in Indian rupees instead of Japanese yen to insulate from forex fluctuations. Addressing shareholders at its annual general ... OnCars.in, 1 month ago
The Alto K10 redefines the concept of a makeover - Deccan Herald, 4 days ago
Maruti Launches Revamped Alto K10 - Businessworld India, 1 month ago
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Suzuki Motor's China sales up 11.5% in Nov
(China Knowledge) Suzuki Motors Corp, Japan's second largest mini car maker, has said that its auto sales in China grew 11.5% year on year to 22,587 units in Nov this year. The figure for last month was higher than the 22,100 units it realized in a ...China Knowledge Online, 1 week ago Maruti Suzuki, Tata Motors November Sales Go Up; Mahindra Lags NDTV Profit, 2 weeks ago TABLE-India's Maruti Suzuki Nov vehicle sales up 19.5 pct y/y Wards Auto.com, 2 weeks ago Monthly sales figures to drive auto stocks Hindu Business Line, 3 weeks ago
Suzuki Hustler Minicar wins 2015 RJC Car of the Year Award
TOKYO — Suzuki Motor Corp's Hustler minicar has won 2015 RJC Car of the Year award, the fifth win for Suzuki. The award was given by the Automotive Researchers and Journalists Conference of Japan (RJC). Hustler has pioneered a new genre as a ...Japan Today, 1 month ago Suzuki Motor second quarter profit falls 14% as tax hike hurts Livemint.com, 1 month ago Suzuki profit falls for 1st time in 8 quarters KiniBiz, 1 month ago Suzuki Motor profit falls for first time in 8 quarters as tax hike hurts Sharenet, 1 month ago
More from: Reuters, NDTV Profit...and 21 other sources
Suzuki Hungary unit to return to double shifts - report
BUDAPEST, Nov 19 (Reuters) - The Hungarian unit of Japanese automaker Suzuki Motor Corp will return to two-shift production in December from one shift, according to national news agency MTI. The Suzuki unit is one of the major auto companies that ...Wards Auto.com, 1 month ago Suzuki Hungary to return to two-shift production in December TeleTrader.com, 1 month ago
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Document Format Files Seq Description Document Type Size 1 FORM F-6EF t1401958x63_f-6ef.htm F-6EF 45825 2 EXHIBIT (A) t1401958x63_ex-a.htm EX-99.(A) 68409 3 EXHIBIT (D) t1401958x63_ex-d.htm EX-99.(D) 6835 4 EXHIBIT (E) t1401958x63_ex-e.htm ...SEC Filings, 2 months ago
Toyota asks Daihatsu minicar to help in India
TOYOTA Motor Corp is struggling to crack the affordable end of India's car market and has called on mini-car affiliate Daihatsu for help — a tacit admission that the Japanese auto giant doesn't always get it right in emerging markets. A similar ...Shanghai Daily, 1 month ago Toyota may rope in Daihatsu to boost Indian small-car presence Domain-B, 1 month ago Toyota in India Reuters India, 1 month ago EXCLUSIVE-Struggling in India, Toyota asks Daihatsu minicar unit to help - sources CNBC, 1 month ago
Maruti Ciaz and Hyundai Elite i20 price hike in the offing
Two of the largest car manufacturers in India, Maruti Suzuki and Hyundai Motors are planning to increase price of their cars, including their latest cars Ciaz and Elite i20 respectively. Hyundai Elite i20 was launched less three months ago, while ...Rush Lane, 1 month ago Mahindra Bumps Up Vehicle Prices by up to Rs 11,500 International Business Times India, 1 month ago Car Makers Mull Price Hike in India; Ciaz, Elite i20 May Get Costlier International Business Times India, 1 month ago Hyundai i20 Elite, Maruti Ciaz may become pricier Economic Times, 1 month ago
Toyota Aqua stays No. 1 in vehicle sales for 2nd mth
Jiji Press Toyota Motor Corp.'s Aqua subcompact hybrid was Japan's top-selling vehicle for the second consecutive month in November, industry data showed Thursday. The gas-electric vehicle sold 16,520 units. Suzuki Motor Corp.'s Wagon R ...The Japan News, 2 weeks ago The Top-Selling Japanese Cars 24/7 Wall St, 3 weeks ago
Nikkei rises on weak yen, ECB stance; Suzuki Motor, Takata fall
* Suzuki Motor tumbles to 1-week low on weak earnings * Nikkei prone to profit-taking when it nears 17,000 - traders * Takata falls after NYT says company hid risks TOKYO, Nov 7 (Reuters) - Japan's Nikkei share average rose on Friday ...CNBC, 1 month ago
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Hero To Launch 2 Scooters & 2 Bikes Next With Non-Honda Engine [Scoop]
Hero is betting big on the scooter segment in the country You read it first on MotorBeam. Hero MotoCorp has made big promises but we are yet to witness much action from India's largest 2-wheeler manufacturer. After firing new engines and ...MotorBeam.com, 3 days ago
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Dr. Lawrence Yao specializes in diagnostic radiology, radiology in Bethesda, Maryland.
Dr. Lawrence Yao has been compared 11 times. Details of Dr. Yao's 29 years experience as an MD, his hospital affiliation and education at Brown University are available on your free doctor report.
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Dr. Lawrence Yao has been identified as specializing in Diagnostic Radiology and Radiology.
He obtained board certification from The American Board of Radiology for Radiology.
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Dr. Lawrence Yao has been confirmed to have a license in Virginia , Ohio , Maryland , California , Texas and Washington DC
Dr. Yao attended medical school at Brown University Alpert Medical School and graduated in 1985 having 29 years experience.
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2nd Think Space UNCONFERENCE 22 - 24 Feb, 2013, Zagreb, Croatia.
The video refers to the project "Peak eye" which was awarded with the
second prize by the jurors Zaha Hadid and Patrik Schumacher within the
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Simple question: Do you have any plans for a Linux port? This looks sweet and I'd like to play this on my preferred OS.
I Shall Remain is a Post Apocalyptic ARPG game with Survival aspects. Located in the old New York city at the end of WW2, when Nazis managed to release a deadly virus over US territory, the game puts you in charge of finding a cure and at the same time, keeping alive Humanity's hope of survival.
0 comments by florinudrea on Dec 4th, 2014
Note: Since a lot of logical changes have been made to Doctrines and Weapons, it is suggested to start a new game in order to have it working correctly (the game won't crash but the doctrines and weapons won't do what people were used to have them doing)
Key features in the I Shall Remain Sixth update.
- Ellis Island map extended and updated
- Two new maps are in (Holland Tunnel Subway and Alphabet City)
- Doctrines have been revamped and updated, 28 new doctrines have been added (128 in total now to shape your character)
- New doctrine effects (avoid explosives, max encumbrance, pierce armor, more scraps from weapon dismantling)
- Weapons have levels now, the level influencing their characteristics (damage, repair cost, most of the weapon effects, serum cost)
- We can now upgrade our weapons by spending scraps/serum (Enhance ammo, Increase rarity, Increase Level, Add random weapon bonus). This opens up new possibilities to upgrade and improve your weapons
- Weapon Enhancer loot items added (these represents an effect we can apply on a weapon, from range to damage or inflict weakness). This opens up endless possibilities to customize your weapons
- 10 new Infected mutations added (Regeneration, Burden, Drain, Osmosis, Enrage, Rejuvenation, Acute sense, Aura, Armor, Crowd), each with its own logic to improve the infected behavior and statistics. We have now 22 mutations the Infected can have in any combination)
- Added "Unique' rarity. 8 new Unique weapons created, all given as quick-events rewards. Some of them have special names :)
- Large texture overhaul. Recreated many textures and adjusted others. Generally higher resolution, new normal mapping and sharper details overall
- Main and secondary quests and content added and updated (new quests from Andrea, Thomas, Jim, Chain, Jay, Cathy)
- 12 new music pieces are in
- New teammate - CJ Hodges (Sibling and Commander abilities)
Other changes
- Secondary textures and materials for all Infected types are in
- We can now fight other humans (will continue to improve over the AI in the next releases)
- Doctrines UI updated
- Weapons loot drop from Infected increased
- Support for teammates to signal they want to talk to you
- Many of the maps adjusted with more bosses, most bosses updated to use some of the new mutations
- Two new common zombie types added (Lurker, Strider)
- Tiredness renamed to Fatique
- Tommy's flashlight ability replaced with Chemist (improves blood to serum conversion)
- After rain preset specular adjusted
- Reverted specular power in sewers (was wrong since the rainy days specular was changed)
- Adjusted damage calculation.
- Fixed "reading a book doesn't unlock Apprentice doctrine" issue.
- Fixed reflection parameters (it was marked as 3d but we were using only 2d one, reflection factor is back to 1 now)
- "highest" option added for Shadowing (difference between high - highest is the Lightning shadows), default is Highest now
- All infected have glowing in the dark eyes now based on their rank (default, Elite, Boss)
- Fix not showing 0 damage for invulnerable teammates.
- Bosses always drop at least rare weapons
- Adjust infection/fatigue hints
- Now leaders have 1-2 additional mutations and bosses have 3-4 additional ones
- Stamina damage floating text support added
- Adjust loot generation algorithm
- Mutations parameters adjusted
- Do not apply penalty for chance to hit in case of low stamina.
- Coloth doesn't use the Defense mutation from now on
- Add more experience to Survival skill from blood-serum conversion action.
- Add floating text for weapon losing durability and repair weapon.
- More hints added
- Dialog changes to have multiple characters talking with the same NPC
- Adjust boss location trigger size in cp1 (to match special event trigger size and position).
- Increase time for Beizel quick event.
- Switch Tommy's abilities (now he starts with Cartographer and unlocks Chemist after 3 levels in squad)
- Update monster UI info while shooting from tank.
- Reduce leaders weapon loot chance from 33% to 25%.
- When we die, teammates current's command defaults to regroup (since we restart the scene or from a checkpoint)
- Show correct heal value as floating text in case of heal using medical kit.
- Add more info in mutations tooltips.
- Adjustments to bazooka projectile
- Fixed the character translation in fixed camera character controller in some of the maps (looked bad when walking/running)
- Grass updated in some of the scenes
- Give random loot for teammates also (not only the main character).
- NPC material in survive mode adjusted (was looking bad)
- Adjusted the font size for teammates tooltips.
- Adjusted weapon contextual menu (inventory and equip slots).
- Adjust upgrades tooltip.
- fix for zombie baby dying with explosion (they weren't going through the same code other zombies did when die so there was no loot thrown and boss music never stopped because of that)
- Add filters buttons for skill doctrines.
- Health mutation will only add 100% health, not 200% how is currently setup
- Health level adjustments for normal zombies
- Instant rejuvenation adds 15% for bosses, 25% for the rest now
- Adjusted teammates health in UI after load.
- Add Medical kit and Water to doctrine traders in safe havens.
- Mines won't get activated by barrels anymore
- We do not show doctrines in skill info window anymore
- We do not flicker skill UI in character window anymore
- Show how many upgrades are available for each skill in doctrines window.
- Use loot bonus from doctrines for loot weapons.
- Upgrade doctrine's prices.
- Apply noise inhibitor for snipe rifle.
- Increase next serum shot value when using Infection Kit.
- Several adjustments to scene from a list of issues reported by a player
- Fix "cannot replace a weapon bonus when the weapon already have 4 bonuses" issue.
- Add Z0M81 Virus item.
- Increase the time for cp1 Infants quick event.
- Adjust Infected window to show more mutations
- Infected tissue items added
- Adjust the "Morgue", "Ammunition stash" and "Investigate the shooting" quests to start them when enter in certain locations.
- Made Julia a trader.
- By default newlyborn halflings have regeneration mutation on
- Mantis has 25% chance to leg hit
- Added option for an NPC to show/hide as told by the spawner
- Added "go to main menu" fail condition to quick events.
- Set Can_be_controlled_by_player property for teammates spawners in existing scenes.
- Reinforce cost is now equal with the weapon's level / 2
- Enhance ammo using serum cost is now equal with the weapon's level / 2.
- Adjusted weapon bonus item price regarding the effect.
- Adjusted the loot chance for weapon bonuses.
- Mouse cursor fix to show after we exited and re-entered from the desktop
- Fixed "Do not use monster resistances in case of teammates". This made teammates level up a lot slower, this should improve that.
- Knife larger hit angle 45, it is possible to fight correctly with the knife now
- Maximum number of bonuses is rarity dependent: 3 for Uncommon, 4 for Rare and 5 for Elite.
- Gain experience from upgrade weapons operations.
- Show messages for starting, completed and failing quests.
- Send "goto main menu" event when changing scenes to fail defend area quests and quick events.
- Made Beizel less powerfull
- Correction when show the damage for weapons in weapon tooltip.
- Mutations reset correctly when we exit the game now
- Overall mutations parameters adjusted
Simple question: Do you have any plans for a Linux port? This looks sweet and I'd like to play this on my preferred OS.
Tell you what, if there's continued interest in a Linux build we will definitely do it! A few people have asked us already about it, if you guys keep it up we're gonna have to do it for ya! : )
I am also keen to see a Linux client, will feature it on www.gamingonlinux.com :)
I'd be keen to see a Linux client.
irc.freenode.net/#steamlug is watching you. I know this because a bunch of other Linux users told me to post here. My guess is, be prepared for a horde.
Thanks for the Linux consideration!
+1 for Linux :)
Sign me up. Just remember to have a x64 build please!
+1 for linux port
The game looks good. It would look even better to me if it ran on Linux.
New voicework has started today! We are so excited! Teresa Lim from Australia and Robert Burton from Washington are bringing two of our characters to life!
Stay passionate my friends in the things you do!
(isr fanpage)
I've just had two really great interviews, Nick from Structure gaming interviewed me from Afghan-land and wrote up a great article and Tony Lombardo put us on the cover of the Marine Corps times. Thank you so much for your support.
Fans! Production continues. We're about 1/3 of the way done with the next release. This next release will be our make or break so we're putting in a lot of new content. We can't wait to share it with you. And hey, I hope you don't mind building barriers- there's gonna be quite a bit of this in episode 1's final mission.
Thanks again! Stay passionate about the things you do, never give up and play ISR!
(link to facebook fan page)
Check out my interview with ISRgame's Jake Way:
Nice! Good interview!
when will the full game be out?
Hey thanks for your interest! We're working on the next episode, I expect there to be about 5 hours of gameplay depending on how much you utilize the free roam aspect on it. A fantastic story + script, voice acting and some new features will come with it. We can't wait to share it with you.
The game will be released in episodes, the next episode is planned to be out in about a month!
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News International Could Face Bribery Charges in U.K. (Report)
LONDON – News Corp.'s News International, Rupert Murdoch's British publishing division, could face corporate corruption charges over alleged bribery of public officials.
According to a report in The Telegraph Friday, the possibility emerged after it wasreported that journalists being investigated over alleged payments to public officials are being put under pressure to implicate senior executives at News International.
More than 20 journalists at News International's tabloid The Sun have been arrested as part of the police's Operation Elveden, the codename for the bribery investigation.
Some hacks have been apparently asked to identify bosses at News International who may have known about or condoned payments to public officials in return for information.
Operation Elveden was launched by the police in the wake of the phone-hacking scandal that engulfed News International.
According to The Telegraph, one of the journalists is said to believe that police are looking for evidence that could implicate News International at a corporate level in the alleged corruption.
The 1906 Prevention of Corruption Act allows charges to be brought at a corporate level.
For the law to be brought into play it would require that a "controlling mind," likely to be board member, was aware of the illegality.
Charges could also be brought under the 2010 Bribery Act, but this is unlikely to be used against News International, as the relatively new law can only be applied to illegal acts committed after July 2011.
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What does PSU mean in Unclassified?
This page is about the meanings of the acronym/abbreviation/shorthand PSU in the Miscellaneous field in general and in the Unclassified terminology in particular.
Pre Screen Unit
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"PSU." Abbreviations.com. STANDS4 LLC, 2014. Web. 22 Dec. 2014. <http://www.abbreviations.com/term/168789>.
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- Aug 13, 2008
Hyundai Genesis gets introduced to DUB
Who says you need to wait for Hyundai's Genesis Coupe to get your tuning freak on? Not the rims and system folks over at DUB, who took two Genesis (Geneses?) and kitted one out like, well, KITT, and the other kind of like a Stormtrooper from Star Wars. For an interior we can't exactly describe as attractive, the white one's not that bad -- certainly not as bad as it could have been. Still, following Wesley Snipes' advice from Passenger 57, we're going to bet on black. Check out the gallery of hi-res images below. Thanks for the tip, Hyundaifan!
[Source: Bobaedream via Hyundai Blog]


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By Jason Ford
As expected, Godolphin's new recruit Discreet Cat ran out the facile winner of a mile conditions race on the Nad Al Sheba dirt Thursday night to secure his berth in the UAE Derby (UAE-II) in just over two weeks time.A good performance in that classic, over nine furlongs on the same dirt surface, could see him take his chance in the May 6 Kentucky Derby (gr. I). The 3-year-old son of Forestry, a good winner for Stanley Hough on his sole previous outing, was never extended to win on Thursday, albeit a weak race, but he posted a fair time given the ease of his victory. Trainer Saeed Bin Suroor was delighted: "He is a very nice colt and has been improving all the time in his work. We were very hopeful of a big run and he has done it very well. That will have done his confidence the power of good and next step is the UAE Derby. How he gets on there will determine whether he goes to Kentucky or not." Godolphin racing manager Simon Crisford added: "We are really pleased and that is a very nice introduction. Hopefully he will come back for the UAE Derby as long as he is okay in the morning. He is a really nice colt who had been training well and we were hopeful he would win well. It is a relief when they actually do it though."
Discreet Cat Victorious in UAE Derby Prep
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text: We're sorry, Rainbow Swirly Lollipop is out of stock Why not try one of these instead? Red And White Swirly Lollipops by 3 Blonde Bears £1.50$2.86€1.97$2.51 Party Sweetie Bag by Chocolate by Cocoapod Chocolate £1.85$3.52€2.43$3.09 Set Of Two Wedding Couple Favour Biscuits by Shortbread Gift Company £1.75$3.33€2.30$2.93 can be personalised Whirly Candy Lolly For Party Bags by Chocolate by Cocoapod Chocolate £1.60$3.05€2.10$2.67 Rainbow Swirly Lollipop by The 3 Bears One Stop Gift Shop £1.50$2.86€1.97$2.51 14 customer reviews(14) This item is currently unavailable free gift wrap £1.75$3.33€2.30$2.93 mainland UK delivery £1.75$3.33€2.30$2.93 mainland UK delivery £5.70$10.87€7.50$9.54 Two Day Delivery Express delivery available International delivery available personalisationpersonalisation (required)lollipop onlywith personalised tag (+ £0.50)personalisation (required)lollipop onlywith personalised tag (+ $0.95)personalisation (required)lollipop onlywith personalised tag (+ €0.65)personalisation (required)lollipop onlywith personalised tag (+ $0.83) name for personalisation we're sorry we're sorry, This item is currently unavailable it will be available on 24-12-2014 quantity buy a gift voucher related categories baby & child > children's parties > goodie bags & gifts for goodie bags baby & child > children's parties > little party extras food & drink > sweet treats by The 3 Bears One Stop Gift Shop Location: West Sussex, GB read seller's profile see seller's complete range more items from this seller Animal Or Monster Hand Temporary Tattoos £5.50$10.49€7.24$9.20 Christmas Peppermint Candy Cane £0.65$1.24€0.85$1.08 Balloon Modelling Party Kit £9$17.17€11.85$15.06 Crochet Ice Cream Rattle Soft Toy £6$11.44€7.90$10.04 Scary Halloween Hand Temporary Tattoos £5.50$10.49€7.24$9.20 Finger Printing Art Set £9.50$18.12€12.50$15.90 view all you may also like PRODUCT DETAILS CUSTOMER REVIEWS DELIVERY RETURNS can be personalised free gift wrap Bright and colourful we love these rainbow swirly lollipops. A delicious treat for anyone with a sweet tooth! Watch childrens eyes light up when they see them! Why not use them to brighten up your party table, in party bags, as Christmas tree decorations, or even as favors at you wedding. Or simply as a scrumptious treat for all candy lovers! Their uses are endless. Who wouldn't want one! Fancy having these personalised as well? We can add a gift tag with a printed name on it. Just select personalised from the drop down menu and add name in the text box. made from: Made in China. Rock ingredients: Sugar, Glucose Syrup, Citric Acid, Flavouring and one or more of the following Colours: E100, E102, E122, E124, E132, E133, E153, E155 and E171. dimensions: Each lollipop is 6.4cm diameter and is sealed in cellophane. product code: 143588 14 customer reviews Thu 19 Jun 2014 No comment supplied. Wed 12 Mar 2014 Perfect. Tue 04 Feb 2014 Look great. Will be a real treat! Thu 30 Jan 2014 No comment supplied. 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Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. The 3 Bears One Stop Gift Shop's return policy


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Drugs, the Olympic Games and amazing blunders on sport's biggest stage. Simon Plumb takes you inside our golden girl's nightmare.
Part I: Val-Gate...Sunday August 5, London
"Valerie is not an automatic qualifier for the Olympic shot put final. She should be on the list. She's not on the list. Management are aware of it and are attempting to rectify the situation. That's all I'm prepared to comment on."
That short phone call to Valerie Adams' manager, Nick Cowan, confirmed breaking news so dumbfounding it was barely believable. The story was urgently emailed back to New Zealand: "Kiwi officials fail to register Valerie Adams for London 2012."
It was hours before Adams was due to defend Olympic gold, the start of incredible controversy and a series of screw-ups so unacceptable that Minister of Sport Murray McCully would call for a formal investigation.
Attempting to hush global embarrassment, the New Zealand Olympic Committee issued a statement citing "an administrative error" but that Adams had been added to the start list. Apparently the matter had been "fully resolved".
But that was only the start of it.
After an out-of-sorts Adams won silver, beaten by Belarusian rival Nadzeya Ostapchuk, it would later emerge she had to beg officials just to print her name bib and be granted access to athlete rooms inside the Olympic stadium. Before Adams could approach media in the tunnel, an NZOC official intercepted - seemingly giving instructions while Adams was looking at the floor nodding.
Interviewing Adams the following morning was delicate, she hadn't slept and was clearly distraught. But she agreed it was time for answers. How could she have been so badly let down?
In a private room in the back of Kiwi House, Adams detailed events through tears and demanded accountability. There was to be a press conference that afternoon fronted by NZOC secretary-general Kereyn Smith, chef de mission Dave Currie and Cowan.
Currie fumbled for answers to simple questions and at one point Smith grabbed the microphone off him. Major inconsistencies were emerging in Currie's story over what had happened with the start list, with Adams' shared accommodation and then, despite agreeing with Adams not to, he proceeded to blame official Raylene Bates for the start-list error.
Part II: The Belarusian...Monday August 13, London
The Games are over, hotel check-out and a two-week holiday are an hour away, and an email from the International Olympic Committee lands: "Ostapchuk disqualified, Adams awarded gold".
The drug story so widely suspected in the run-up to the Games had finally been confirmed by the most solid source possible, and a whole new twist emerged in an already bizarre tale.
While Adams cleaned up on the world track and field circuit in the months before London, Ostapchuk disappeared, traceable only by reports of monstrous throws out of her native Belarus. Ostapchuk had not beaten Adams head-to-head in more than two years and then, all of a sudden, she's booming past her - but behind closed doors.
Many observers sensed exactly what was going on in Minsk.
Questioning of Ostapchuk's results in a July 19 column and pointing to "magical measuring tapes" the day before the Olympic showdown prompted one reader to reply: "Are you suggesting she somehow cheated? Either come out and say it and explain yourself or zip it with the insinuation! How much experience have you got in reporting on shot put anyway, Simon? Rubbish journalism in my opinion."
Cheating was precisely the insinuation. Doping, to be exact.
It was off to Switzerland that night to catch up with newly crowned Adams and coach Jean-Pierre Egger and, for the first time, their doubts over Ostapchuk went on record.
Egger, a highly respected veteran of four decades in elite sport, said he'd long harboured drug suspicions over Ostapchuk. He even asserted Belarus was actively helping its athletes skirt anti-doping rules.
"I am an old fox. I know when people are cheating," he said.
The interview with Adams was understandably much happier than seven days before. There was a party at the Swiss Olympic HQ that afternoon.
But still the saga rolls on, even now Adams has her second gold medal. Four months after Ostapchuk was given a one-year ban for steroid abuse, the IAAF are yet to challenge the light sentence handed down by Belarusian officials - meaning Ostapchuk could be back for the 2013 world championships.
- Sunday Star Times
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Review: Linux Mint 4.0
Mint has struck again! The developers of this elegant Linux distribution are back with a new version of their elegant Linux distribution for you to enjoy. As you may remember, in our previous review of Linux Mint, we introduced you to a Linux desktop that was both elegant and practical for both the new and experienced Linux user. We explored their motto of "From freedom came elegance" and found it to be true in many ways. We even looked at a lot of features that eventaully won Linux Mint a place on our short list of recommended Linux distributions. But now that a new version has arrived on the scene, we're left with one nagging question. What makes Linux Mint 4.0 better than the existing 3.0 version we previously reviewed? Well, a number of things apparently. So let's look at each of these new improvements and see what they have to offer you and if they can truely make Linux Mint 4.0 better than its predicessor.
Initial Impressions
The latest version of Linux Mint, codenamed "Daryna" (don't ask me how to pronounce that because I still haven't figured it out myself) is based on both the Celena version of Linux Mint (version 3.1) and Ubuntu Gutsy Gibbon (version 7.10 of Ubuntu). For those worried about the interface changing a lot, don't fear, because it really hasn't. All the familiar features and organization of Mint are still there, including in the Mint menu. But aside from its familiarity, Mint 4.0 isn't without it's problems. One of the things I found early on was a fair degree of instability in the general system. While it wasn't crashing all over the place, it was still a bit unstable. I even had the background crash and die at least once on me taking the desktop icons and all desktop features with it, which is almost unheard of in other distributions, including Ubuntu.
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More in Tux Machines
Paper: New Material Design Inspired GTK Theme
Paper is a new material design inspired GTK theme, which is currently in beta. "Its design is mostly flat with a minimal use of shadows for depth", mentions its website, and it was developed primarily for the GNOME (Shell) and other desktops that make use of header bars.
Leaving KO
Inge, Tobias and I founded KO GmbH in 2007 in Magdeburg. We named it KOfficeSource, because we believed that KOffice, which is Calligra these days, was getting ready for the big time, especially on mobile. Nokia was beginning to invest heavily into open source, Intel joining in with Moblin, the times were heady and exciting! After a bit of rough-and-tumble about the name, we renamed KOfficeSource GmbH to KO GmbH and from 2010 on, we were in business! Also: Krita and KO GmbH
Second generation Android One phones to arrive in Q1 2015
Karbonn Mobile is preparing to release its second-generation Android One smartphone, according to the Executive Director of Karbonn Mobiles, Shashin Devsare, who recently spoke at the Dream 500 Million Smartphones event in New Delhi. The successor to the Karbonn Sparkle V is scheduled to arrive in the first quarter of 2015.
Open Source Has Won: Now What's Your Strategy?
Nonetheless, open source is here to stay. If your organization isn't using open source software in mission-critical applications, you're in the minority. Even then, I suspect you are using open source software and just don't know it. Even Microsoft has embraced open source by including open source versions of big data repository Hadoop on Azure, and they count Hortonworks and Cloudera among their valued partners. And if you're really one of those rare open-source-free enterprises, you might want to reevaluate your situation: you're in an increasingly small minority.


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Kimpton Plans Hotel Monaco in Pittsburgh
Wednesday September 11th, 2013 - 10:25AM BGP
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SAN FRANCISCO—Kimpton Hotels & Restaurants will expand into Pittsburgh, PA, with the conversion of a Beaux Arts-style building into a new Hotel Monaco.
An adaptive reuse of the city's historic James H. Reed Building, originally built in 1903, the new Hotel Monaco Pittsburgh will feature 247 rooms, nearly 9,000 sq. ft. of meeting and event space and a 120-seat restaurant.
Slated for a late 2014 opening, the nine-story property is located across from Mellon Square and in the heart of the city's Golden Triangle area.
The new hotel's interiors will reflect a locally inspired and distinctive take on the Hotel Monaco style, according to the company.
"We've had great success throughout the Northeast and in Pennsylvania, and Pittsburgh is a logical choice for expansion, especially given the relative lack of boutique-style properties and high demand for that here," stated Kimpton CEO Mike Depatie.
A joint venture with Philadelphia developer PMC Property Group, Kimpton's KHP Fund III owns a 50% stake in the new hotel, making it the company's third owned and operated property in Pennsylvania, along with the Hotel Monaco Philadelphia and Hotel Palomar Philadelphia.
Tags: Kimpton Hotels Restaurants • Hotel Monaco • Hotel Monaco Pittsburgh • Pittsburgh • adaptive reuse • PMC Property Group • Hospitality • Brands • Construction/Renovation • Openings •
When you hear all the lodging industry projections for the months and years to come, much of the robust growth is forecast to be the result of the expected influx of travelers from China. In what could only be seen as good news for the industry, that expectation moved a little closer to reality when President Obama signed a visa waiver extension for Chinese travelers earlier this month.
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Sox-Yanks Score Highest Ratings of Season for Sunday Night Baseball
Neil Best of Newsday is reporting that the overnight numbers for last night's Red Sox-Yankees game on ESPN were the highest for Sunday Night Baseball this season, with 3.6 percent of homes in major markets tuning in. Boston led the way with 17 percent, while New York posted 8.6 percent.
Boston beat New York 3-2 in 10 innings on Sunday to move one game ahead of New York in the standings. Yankees closer Mariano Rivera blew the save in the 9th inning, and Sox right fielder Josh Reddick won it in the 10th on a walk off single off Phil Hughes that scored Darnell McDonald. It was Rivera's 14th blown save against the Red Sox, his most versus any team. Boston has won 10 of 12 versus New York this season.
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Hockey: Great Britain coach dares to dream after win over Pakistan
Ian Herbert
Ian Herbert is Chief Sportswriter at The Independent.
Friday 03 August 2012
Great Britain coach Jason Lee could last night begin to contemplate "shooting for the stars" – meaning qualification for the men's hockey semi finals – declaring after a comfortable 4-1 win over Pakistan that progress was in his own side's gift, despite the brooding presence of world champions Australia, on Sunday.
"It's in our destiny. I don't think I'm worried about topping the group. Top two will do nicely," Lee said and the prime reason for his optimism was the player whom every hockey buff will tell you is the player of this tournament so far. Ashley Jackson, whose penalty corner flicks and a breathtaking piece of goal creation cut Pakistan to pieces, is not generally bigged up by his coach. "I've seen him play better. He tends to play better when the team is better," Lee said of his number 7. "He is someone who will be scoring goals throughout this tournament and his career. Long may it continue!"
But Jackson's goals at the at the Riverbank Arena revealed his pre-eminence in the world game as a corner flicker. Historically, many of the game's finest corner flickers have had to be hidden in teams because they have nothing else to offer but while Jackson has mastered this specialist position with a very unusual technique, powering the ball through his wrists, he delivers other qualities. The breathtaking run which set up James Tindall reverse stick opener, in four minutes, proved the point. Jackson was also involved in the build up to Jonty Clarke's 26th minute strike and contributed his punishing flicked strikes after the break.
World champions Australia's surprising 2-2 draw with Argentina yesterday gives Britain encouragement. "They had 27 shots and they scored one," Lee said of a side whose match intensity is on a another level. "Australia often have funny, odd games and they have had one today." Defeat on Sunday may leave Lee requiring a win in their last game, against unfancied Spain, if the Pakistanis beat South Africa in their own penultimate game.
Pakistan were poor, offering minimal trouble to goalkeeper James Fair who produced a fine double save from two successive Sohail Abbas corner flicks. Their general manager insisted that they are not done yet: "The tournament is still open, it's not closed."
But Abbas sees something striking in Lee's side. "They have changed a lot. You see this team has totally changed. They are playing like a champion team. The name of GB hockey is coming up. I've played hockey against them for 14 years so I have seen a lot."
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- magical costume! Review by Farah
Just adorable. My daughter barely took it off after Halloween!
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How to Decorate for a Roaring 20's New Year's Eve Party
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Make Your Holiday Parties Merry and Bright with Holiday Hats!
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No New Year's Eve Party is complete without a few accessories! Add a hat, beaded necklace and a noisemaker to your New Year's party attire for a fun night.


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The state shows a candidate's ability to win support in the heartland. It could help Romney in his effort to peel back states Obama won in 2008, or help Obama put Romney away.
Obama has already spent more than $2.6 million on advertising, a pace as aggressive as in any other battleground state. He's been a regular visitor, and was making his second trip in a month.
Yet the president's approval rating here has been stuck below 50 percent for over two years, softened in part by criticism from Republicans campaigning for Iowa's leadoff caucuses.
Republican Terry Branstad took back the governorship easily from Democrat Chet Culver in 2010, as the GOP won back the state House and came close in the Senate.
Polls show Iowans also have become increasingly bothered by federal spending, an issue Romney stoked in Des Moines last week in a visit where he promised to shrink the deficit.
Iowans, many of whom met Obama in the 2008 campaign, also are disappointed by what they hoped would be a transcendent presidency, said J. Ann Selzer, the longtime director of The Des Moines Register's Iowa Poll.
"You hear disaffection. You hear them say, 'This isn't what I paid for,'" Selzer said. "The guy they sent there to recast things wasn't able to do it."
Obama made his latest trip to a swing state while his campaign manager, in Washington, privately updated Senate Democrats on the state of the race. Officials said Jim Messina told lawmakers the president has several possible paths to collecting the 270 electoral votes he needs for victory in November.
But Messina also noted that Romney, the Republican Party and allied super PACs are likely to have a great deal of money to spend. Obama vastly outspent Republican John McCain in winning the White House four years ago, an advantage that Democrats appear unlikely to command in 2012.
Romney senses the opening.
He, too, has cultivated an Iowa network. Indeed, he campaigned aggressively for the 2008 caucuses during his narrowly losing bid for the state's delegates. And his campaign has begun running television ads in Iowa.
Romney and the Republican National Committee have hired state directors and are hiring staff to run a dozen or more offices planned for Iowa.
While Obama campaigned here, Romney spent Thursday visiting an inner city charter school in west Philadelphia. Romney was to spend the weekend in La Jolla, Calif., with his family.
AP Special Correspondent David Espo in Washington contributed to this story.
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The Cornetto Trilogy ft. Edgar Wright, Nick Frost, and Simon Pegg!
in Film
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in Movies
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Plus, reviews of Lee Daniels' The Butler and Kick-Ass 2!
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in Sports
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Live, Love, Laugh Presents Deacon Erica Wright and the U First Project
The Heart of Love Radio Show with G. Wright
Please come through and listen to some great music and inspirational conversation and leave refreshed.
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Considered by many to be one of the leading thinkers in human development, Dr. Bob Wright (www.drbobwright.com) is an internationally recognized visionary, educator, program developer, author, speaker, relationships expert, entrepreneur, consultant, and executive coach.
Dr. Bob founded the Graduate Institute for the Realization of Human Potential and the Foundation for Transformational Leadership. Dr. Bob Wright's degrees include a BA in Sociology, MA in Communications, MSW in Clinical Social Work, and a Doctorate in Education, Leadership, and Change.
Getting Closer to Your Partner over the Holidays
in Romance
It's about that time of the year again where you drag the kids to his parents, and then her parents... and she doesn't want you bringing up dad's new hobby, and he just wants to relax this year... and how long are we going to stay with so-and-so with the kids?
Wait a second... what happened to the spirit of the season?
Listen to this episode of Bring Out The Best with relationships expert Dr. Bob Wright as he coaches individuals on how to talk with your partner over the holidays so that you both reach unison and agreement and can get back to enjoying and celebrating.
Do you want to be on an upcoming show of Bring Out The Best? Call 312.645.8300 or email firstname.lastname@example.com to secure your spot to get coached by Dr. Bob Wright!
In this episode, listeners will be receiving:
A free gift of Two Free Chapters of Transformed! The Science of Spectacular Living
$200 off the TTBundle valued at $1,200 and currently sold for $297. Plug in limited time holiday code blogbundle to receive your package for only $97!
Joy Keys chats with Author Bridgett M. Davis about her book Into the Go-Slow
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It's 1986, and twenty-one-year-old Angie is adrift in her hometown of Detroit. Her older sister, Ella, had disappeared in Lagos a decade earlier, and Angie decides to retrace her steps. Against a backdrop of Nigeria's infamous go-slow—traffic as wild and surprising as a Fela lyric—Angie begins to unravel the mysteries of the past, and opens herself up to love and life after Ella.
BRIDGETT M. DAVIS's debut novel, Shifting Through Neutral (Amistad 2004), was a finalist for the 2005 Hurston/Wright Legacy Award. Davis is the books editor at Bold As Love Magazine, a black-culture website, and her work has appeared in the Washington Post, Essence, O, The Oprah Magazine, and The Root.com, among other publications. She is a professor at Baruch College, City University of New York, where she is the director of the Sidney Harman Writer-in Residence Program, and she is the curator of the popular monthly Brooklyn reading series, Sundays @ . . .http://bridgettdavis.com/
Chely Wright / Shawn Levy / Christian Kane // The Matthew Aaron Show
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Goodbye 2014, Merry Christmas and Happy Holidays!!
in Sports
The #1 Trading Card Talk Show, now in its 14th season. Join us for 90 minutes of trading card talk with industry pros, athletes, entertainment stars and collectors from around the globe. Hosts Doug Cataldo, Rob Bertrand, Russ Cohen and David Wright will take you into the wild world of trading cards and memorabilia.
Panini America
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Visit the Cardboard Connection for all of your trading card needs.
Also, be sure to visit the hosts' blogs:
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Long Fly Ball
Multiple award-winning crime fiction author Tim Hallinan on Authors on the Air
in Books
Authors on the Air Host Pam Stack welcomes author Timothy Hallinan to the studio. Edgar, Shamus, Macavity and Lefty nominee Timothy Hallinan has written 16 published novels, all thrillers and mysteries. He currently writes two series, one set in LA and the other in Bangkok.In the 1990s he wrote 6 mysteries featuring the erudite private eye Simeon Grist, beginning with "The Four Last Things," which made Ten Best lists, including The Drood Review. The other books in the series were well reviewed, and several were optioned for motion pictures. The series is now a cult favorite. Since 1982 he has divided his time between Los Angeles and Southeast Asia, the setting for his Poke Rafferty novels. Visit Tim's website at http://timothyhallinan.com. On Amazon at http://www.amazon.com/Timothy-Hallinan/e/B000APW06C.
Thank you to author Robert Gregory Browne who composed and plays our theme music. Underwriting generously provided by Michal Lowndes at PML Media, Inc & Author Marketing Hub, building SEO , mobile device friendly websites exclusively for authors. Sponsorship comes from Lindsay MCKenna author of military romance; JCarson Black, author of intelligent crime fiction and 2014 BOOK OF THE YEAR winner; D.D. Corbitt, author of "The Amaretto". Local sponsorship given by Discount Pets & Supplies; order online at http://discountpetsandsupplies.com.
This is a trademarked copyrighted podcast solely owned by the Authors on the Air Global Radio Network LLC.
Bossman Show (12-13-14 Branson Wright Interview Replay)
in Sports
JR The Bossman (@JRTheBossman) and John Beckler (@JDBeckler) were joined by Cleveland Plain Dealer Writer Branson Wright (@BransonWright).
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vt jobs
Locumtenens.com- Vermont
Hospitalist - Vermont Fulltime IM trained hospitalist, employed position, 12 shifts in 28 days, 10 hour shifts, malpractice paid, good health benefits, good retirement, very...2 days ago from LocumTenens.com
VT- Nocturist - Hospitalist openingNEW
Locumtenens.com- Vermont
Hospitalist - NocturnistWe are looking for an Internal Medicine Hospitalist to join our team of fifteen. We are the second largest hospital in the state and licensed for 188 beds.2 days ago from LocumTenens.com
VT - Co-Manager
Hobby Lobby- Vermont
Job Description: ARE YOU LOOKING FOR A COMPANY THAT VALUES PEOPLE? Hobby Lobbys success begins with our people, and that beginning could start with you! Our company is growing and...20 days ago from Hobby Lobby
Travel ER Nursing Job in Middlebury, VT (42449202)
Soliant Health- Middlebury, VT
In Middlebury, Vermont we have a urgent ER Travel Nursing Job for a 13 week assignment. This job is offering same day interview and offers! You can't beat that! Soliant Health...9 days ago from Soliant Health
Join growing employed group in VT and make strong comp and full bennies - 216336NEW
CompHealth- Vermont
Join a well-established group in an employed capacityWork in state-of-the-art facility with the latest diagnostic technologyReplace a physician who has built up a full practiceSee...2 days ago from Locum Jobs Online
SLP (Speech Language Pathologist) Job in Pittsford, VT - Part Time!
Procare Therapy- North Chittenden, VT
We have a contract job opening for a part-time Speech Language Pathologist (SLP) with their licensure in the state of Vermont! Apply now as the opening is for an immediate need.9 days ago from ProCare Therapy
Locumtenens.com- Vermont
We are looking for a general adult Psychiatrist to practice at our hospital based, outpatient Psychiatric Clinic, which opened in October 2008 Hospital employed physicianAssist...3 days ago from LocumTenens.com
Sales Management Trainee Bennington VT (Enterprise)
Enterprise Rent-A-Car- Bennington, VT
Location: Bennington, VT Job ID: 123097 Regardless of college major or professional experience, nearly 100% of our full-time employees start out in our Management Training...5 days ago from Enterprise Rent-A-Car
Retail Store Manager VT Newport
CVS Caremark- Derby, VT
Successful candidates can move from the CVS/pharmacy Retail Management Development Program as a Store Management Trainee to an Assistant Store Manager to a Store Manager in 1-3...16 days ago from CVS Caremark
Hospitalist - Vermont - Physician Needed - Central VT - $185k+
Staffphysicianrecruiter.com- Vermont
Non - profit critical access community hospital seeking BE/BC Internal Medicine, Pediatrics or Family Practice physicians for expanding hospitalist program. Schedule is 7days on...30+ days ago from StaffPhysicianRecruiter.com
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Pork News
News on Pork continually updated from thousands of sources around the net.
Scandinavian food is for sale across from Spanish food
9 hrs ago | The News-Star | Comment?
Montco pork producer to open Michigan plant
10 hrs ago | Philly.com | Comment?
Pork demand rising globally as industry continues fighting PEDV
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Azul's Interactive Cooking Classes: Preparing Three Courses With William Crandall
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23 hrs ago | Sys-Con Media | Comment?
Helen Frear: My favourite Xmas foods are the small treats
Yesterday | Nottingham Evening ... | Comment?
The Humble Pot Pie Gets a Decadent Makeover
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Try this sweet and savory pork chop with apply chutney dish
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A big herd: Dairy cattle numbers on rise
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