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An apparatus for determining when a patient is susceptible to defibrillation comprises a plurality of electrodes (12, 14) for obtaining an ECG signal from a patient, and data processing means (30, 42) for determining a region of the ECG signal where the signal passes from a first threshold to a second threshold at least equal in magnitude but of opposite polarity to the first threshold while the gradient of the signal remains within certain limits, detecting the next following ECG signal peak, and providing an output signal upon such detection.
1. An apparatus for determining an instant to apply a defibrillation voltage to a patient, the apparatus comprising a plurality of electrodes for obtaining an electrocardiographic (ECG) signal from a the patient, and data processing means for (a) determining a region of the ECG signal where such ECG signal passes from a first threshold to a second threshold at least equal in magnitude to that of the first threshold and of opposite polarity thereto while the gradient of such ECG signal remains within certain gradient limits, (b) detecting the next following ECG signal peak, and (c) providing an output signal upon such detection, wherein said output signal identifies the instant to apply the defibrillation voltage to the patient.
2. An apparatus as claimed in
3. An apparatus as claimed in
4. A defibrillator including an apparatus as claimed in
5. A defibrillator as claimed in
6. A defibrillator as claimed in
7. A defibrillator as claimed in
8. A defibrillator as claimed in
9. A defibrillator as claimed in
10. A defibrillator as claimed in
11. A defibrillator as claimed in
12. A defibrillator as claimed in
13. A method for determining an instant to apply a defibrillation voltage to a patient, the method comprising the steps of obtaining an electrocardiographic (ECG) signal from the patient using a plurality of electrodes, determining a region of the ECG signal where such ECG signal passes from a first threshold to a second threshold at least equal in magnitude to that of the first threshold and of opposite polarity thereto while the gradient of such ECG signal remains within certain gradient limits, detecting the next following ECG signal peak, providing an output signal upon such detection, and applying the defibrillation voltage to the patient upon the occurrence of said output signal.
14. The method as claimed in
This invention relates to an apparatus for determining when a patient is susceptible to defibrillation.
Ventricular fibrillation (VF) is an abnormal rhythm of the heart which proves fatal if left untreated. The only effective treatment in an emergency situation is a high voltage shock applied to the heart either through electrodes applied to the chest wall or through electrodes attached directly onto the heart's surface. This high voltage shock attempts to interrupt the Ventricular fibrillation sequence and thereby restore the heart to a normal activation sequence.
A heart in VF is not effective and circulates very little blood, if any at all. A VF event is therefore probably the most time critical of all medical cases. With no blood circulation, brain tissue death or necrosis is imminent within minutes of the event occurring. The lack of blood supply to the body also compounds the time critical nature of the event because the heart itself requires blood supply via its coronary arteries in order to function efficiently. During VF with the blood supply to the whole body interrupted, the heart begins to experience ischaemia. Ischaemic heart tissue is more prone to VF than normal heart tissue. This means that as the VF rhythm persists, the ability to correct the sequence reduces and the risk of death increases.
There are various different mechanisms by which the Ventricular fibrillation sequence can maintain itself. Unlike Normal Sinus rhythm (a one shot sequence being actively initiated by the Sino-atrial Node), VF is a self sustaining closed loop sequence which is sometimes cyclic in nature but the nature of the sequence and its mechanism invariably changes over time. Furthermore, the mechanism by which any particular VF event is sustained will be related to the primary cause of the event. There are again various cardiac related abnormalities and trauma, which can promote a VF sequence in any human heart. These can be divided into two distinct groups, namely: Primary VF events and Secondary VF events.
Primary events are cases where the VF was an unexpected event. This can either be a sudden spontaneously initiated VF or a VF event due to some other sudden trauma or stress e.g. Acute Myocardial Infarction, Hypoxia, Lighting strike etc. Secondary events are those which occur although suddenly but predictably. These would include VF as a known risk of drug therapy and also patients who have a previous history of spontaneous VF events or rhythms which could promote VF. These two groups are managed differently by modern clinical response.
Secondary events are very well controlled by complex and miniaturised Implantable Cardiac Defibrillators (ICDs) which are surgically implanted within the chest and have electrodes directly connected to the heart. These devices continually monitor the hearts rhythm and deliver a shock to the heart if they detect the abnormal rhythm. Devices such as these have a very high success rate for converting VF since they can respond very quickly.
Primary events however are not so easily controlled. Due to the fact that by nature they are entirely unpredictable, they invariably occur outside hospital and therefore occur in the absence of specialised equipment and or qualified personnel. When they do occur, the response time may be long because an average person will fail to recognise the seriousness of the condition. This means that the event can neither be quickly diagnosed nor effectively treated. The advent of the Portable Cardiac Defibrillator was a significant advance for emergency response teams allowing them access to a very specialised medical instrument outside hospital. The procedure means that primary events can now be treated almost as successfully as secondary events provided the emergency response team can be despatched and reach the patient in time. This delay could be further reduced if the use of Automatic External Defibrillators (AED's) becomes more widespread.
Unfortunately, there is a dilemma associated with external defibrillation. Unlike ICDs, external defibrillators apply the electrical shock across the thorax rather than directly across the heart, requiring much larger voltages in order to deliver the energy to the heart, necessary for termination of the VF rhythm. As a result of this high voltage, very high currents can occur within the thoracic cage and cause significant damage to heart tissue. Clearly this is undesirable and defeats the purpose of the intended treatment. Furthermore, external defibrillation is probabilistic at best. For instance, having established an energy setting which has produced a successful defibrillation in one instance and then attempting to defibrillate with the same or higher energy setting may fail. Of even further interest is the fact that a significantly lower energy setting can be successful, all within the same individual.
For these reasons, low energy defibrillation has been a goal for investigators for many years. The object of the invention discussed here is not however that of low energy defibrillation but rather one of providing a means by which the probability of any defibrillation attempt being successful can be increased. It will become clear later however, that increasing the probability can mean that fewer lower amplitude shocks are actually required to terminate any given VF rhythm. Attempts to reduce the energy delivered to patients requiring defibrillation have evolved from recommended dose protocols, for example a first shock of 200J and if this is unsuccessful then a second shock of 200J and then repeated shocks of 360J until successful or the attempts are to be abandoned; to energy dose based upon patient characteristics, for example changing initial discharge voltage, initial current or the discharge pulse width in order to deliver less energy to patients with a lower Trans-Thoracic Impedance (TTI).
Although these types of refinement have advantages they do not increase the probability of defibrillation success and they can also have serious disadvantages. For example while decreasing the width of a shock pulse and keeping the initial discharge voltage constant for a low impedance patient means the subject receives a lower energy dose, the initial current flow through the subjects torso (and heart) is actually much greater and therefore very damaging.
Present theory projects that the state of the myocardium at the exact instant the shock is applied is actually the determining factor of a successful defibrillation attempt. Experiments changing the shape of the shock pulse itself have shown that different pulse shape characteristics can change the amount of energy required to terminate VF. It is widely accepted that although VF has a random appearance, it is characteristic and can in fact be successfully modelled.
Investigations in this field have shown that the success of a defibrillation attempt is governed by the ability of the applied shock pulse and its shape to successfully organise a critical mass of myocardial cells. Specifically, the critical mass of cells must be placed into the refractory (or recovery) state. If a critical mass can be organised in this way, the heart essentially pauses. The normal sinus pacemaker can then initiate the heart's normal activation sequence and normality is restored.
Recently however, investigators have shown that during VF the heart's organisational state changes over time, and specifically that there are instants during any VF sequence at which the heart is in a more organisational state. Attempts by various investigators to identify these instants (called periods or instants of defibrillation susceptibility ) have only been marginally successful. In 1988 Carlisle et al. synchronised the applied shock to the peaks, troughs and zero crossing points of the ECG during VF, without any significant success.
The object of the invention is therefore to provide a means for determining when a patient is susceptible to defibrillation whereby the probability of any defibrillation attempt being successful can be increased.
Accordingly, the invention provides an apparatus for determining when a patient is susceptible to defibrillation, the system comprising a plurality of electrodes for obtaining an electrocardiographic (ECG) signal from a patient, and data processing means for (a) determining a region of the ECG signal where such signal passes from a first threshold to a second threshold at least equal in magnitude to that of the first threshold and of opposite polarity thereto while the gradient of-such signal remains within certain limits, (b) detecting the next following ECG signal peak, and (c) providing an output signal upon such detection.
The invention further provides defibrillation apparatus in which the occurrence of the output signal is used to trigger the application of a defibrillation voltage across the defibrillation electrodes.
In such case the electrodes providing the ECG signal may be the defibrillation electrodes themselves.
The first and second thresholds and gradient limits may be calculated automatically from measured parameters of the preceding ECG signal, or they may be empirically determined constant values.
In the embodiment to be described the data processing means is implemented in digital circuitry. However, it may alternatively be implemented in analog circuitry or a combination of analog and digital circuitry.
An embodiment of the invention will now be described, by way of example, with reference to the accompanying drawings, in which:
The invention is based on the theory that the instants of susceptibility can be detected and quantified by the average cardiac vector but that the amplitude and velocity of the approaching dominant wavefront is insufficient to accurately determine the instant of susceptibility. The instantaneous direction of the dominant wavefront and the nature of the myocardial organisation responsible for this direction is crucial to identifying the exact instant of susceptibility.
Further considering
This particular activation sequence (with the repolarisation wave following behind the initial depolarisation wave) is typical of atrial tissue. Ventricular tissue actually repolarises in the opposite direction to which it initially depolarises. In terms of the measured ECG and
Now let us consider a VF trace and how myocardial tissue generates such a trace.
If we now return to FIG. 6 and consider again how these individually circulating wavefronts interfere with each other over time, then we can see that the average cardiac vector and it's measurement (the ECG trace) is generated by the activation wavefronts combined. Note also that the act of measuring a threshold or a gradient at that threshold is not sufficient to determine the activation state of the tissue. Since the amplitude of the ECG trace is due to both the mass of tissue activation together with the direction in which it is activating they cannot be separated by a threshold. Furthermore the gradient only reveals the speed at which the overall wavefront is approaching or receding.
Furthermore it is crucial that the polarity of the defibrillation shock is such that the critical mass of cells are depolarised and that the shock is not applied across the tissue in a direction attempting to reverse repolarisation. A reverse polarity shock would require more energy since it would have to both reverse repolarisation and then depolarise the critical mass, a process which is very unlikely since having attempted to reverse repolarisation, the critical mass of cells will be less likely to depolarise properly and the VF sequence would simply persist. Thus, as shown in
The invention is equally applicable to positive-to-negative-going portions of the ECG signal, in which case one would detect a region of the ECG signal where the signal passes from a positive threshold of significant magnitude to a negative threshold at least equal in magnitude to the positive threshold, while the gradient of the signal remains within certain limits, and the optimum point for defibrillation would be at the next following local minimum of the ECG signal
An embodiment of the invention is shown in
Signal Conditioning and Amplification circuit 30 receives the signals from the individual defibrillation electrodes 12, 14 and generates therefrom in known manner the ECG signal for display on the monitor 18. Energy Select circuit 32 is responsive to the setting of the rotary dial 22 to establish the selected energy level and, when the push button 24 is pressed, Charge circuit 34 charges the capacitor to a level corresponding to the selected energy level.
In the prior art, and as indicated by the dashed line, Shock Enable circuit 36 is directly responsive to the operator pressing the push button 26 to provide an input to Shock Delivery circuit 38, causing the latter to immediately discharge the capacitor through the electrodes 12, 14 to deliver a defibrillation shock to the patient. However, in the present embodiment the Shock Enable circuit 36 provides instead an input to Trigger Shock circuit 40 interposed between circuits 36 and 38. The Trigger Shock circuit 40 also receives an input from Shock Point Detector circuit 42 which is responsive to the ECG signal from circuit 30 to detect instants susceptible to defibrillation according to the principles of FIG. 9. The Shock Point Detector circuit 42 provides the said input to circuit 40 when such an instant is detected.
The Trigger Shock circuit 40 is essentially an AND circuit and, when it receives an input simultaneously from both circuits 36 and 42, it provides an input to the Shock Delivery Circuit 38 which causes the latter to immediately discharge the capacitor through the electrodes 12, 14 to deliver a defibrillation shock to the patient. Thus, as compared to the conventional external defibrillator which provides a defibrillation shock immediately the button 26 is pressed, which can occur at any arbitrary point during the ECG cycle due to the rapid changes in the signal and the relatively slow reaction of the human operator, in the present apparatus when the button 26 is pressed the apparatus waits until the Shock Point Detector circuit 42 identifies an instant susceptible to defibrillation and only then administers the shock. Such instant will typically occur a fraction of a second after the button 26 is pressed, and thus the button 26 must be held down until the shock is given. Optionally, if no suitable instant is detected within a predetermined time, say about two seconds, after the button 26 is pressed, the apparatus may be designed to administer a shock at that point anyway. The shock is preferably an n-phasic truncated exponential shock where n is greater than one. That is to say, it consists of several truncated exponential voltage pulses of alternating polarity. In particular it may be a biphasic truncated exponential shock.
The implementation of circuits 30 to 38 is well known in the art and does not need further description. Also, circuit 40 is essentially an AND circuit and is readily implemented by those skilled in the art. The function of the Shock Point Detector circuit 42 is performed in this embodiment by a suitably programmed microprocessor. In order to allow the microprocessor to process the ECG signal an analog-to-digital (A/D) converter (not shown) is used to convert the analog ECG signal to digital form.
The invention has been used to identify the instant of susceptibility in each case. This means that the energy required to defibrillate (either single shock or through multiple sequential shocks) is considerably less than would be required to activate a critical mass at a time instant that is not susceptible.
Although the above embodiment has used the same electrodes for both defibrillation and to provide the ECG signal which is analysed to determine the instant of susceptibility to defibrillation, the ECG signal could alternatively be derived from separate electrodes.
Also, although the foregoing has described the invention in the context of an external defibrillator, i.e. where the electrodes are connected externally to the patient's body, it will be clear to those skilled in the art that the invention may be used to determine the instant of susceptibility to defibrillation in the case of implanted electrodes which are connected directly to the heart's surface.
The invention is not limited to the embodiments described herein which may be modified or varied without departing from the scope of the invention.
Patent Citations
Referenced by
Legal Events
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UEFA Champions League Preview: Manchester United-Real Sociedad
Manchester United has been on everybody's mouth this season as their transition from Sir Alex Ferguson to David Moyes hasn't been as smooth as they thought it might be. However, they will be able to put all of those things aside as they host a Real Sociedad side that needs the three points if they want to keep their Champions League qualification chances alive.
The Red Devils are currently the leaders of Group A with four points in two matches, while the Anoeta side are sitting in fourth place after two losses against Shakhtar Donetsk and Bayer Leverkusen.
The Old Trafford outfit have several key players that can be difference-makers at any given moment, but no one is more important for the team than Wayne Rooney right now. The British international is the undisputed leader of the team both on and off the pitch, and he seems to step his game up every time his team needs him the most. Look for him to have an outstanding performance against a very tough defensive unit.
Real Sociedad are a team that rely heavily on their collective strength, and they are known for employing a very defensive tactic when playing away from home. One of their most consistent performers is goalkeeper Claudio Bravo, and his performance will be key to maintain La Erreala in the game early on when the Red Devils put the pressure against his goal.
Prediction: Manchester United 2-0 Real Sociedad
Despite their early struggles this season, Moyes' men won't have much trouble to get past the challenge of Real Sociedad. A stunning performance from their forwards and a solid outing at the back will be enough for the home side to get another much-needed win in the tournament.
Juan Pablo Aravena is a sports writer for RantSports.com. Follow him on Twitter @jparavenarant or add him to your network on Google
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subset: commoncrawl


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tag:blogger.com,1999:blog-59504869006627653.comments2014-12-22T08:18:52.356-05:00An Enchanted email@example.com:blogger.com,1999:blog-59504869006627653.post-39139067769001973082014-12-05T22:07:50.309-05:002014-12-05T22:07:50.309-05:00What a lovely patio decorations.. I really admire ...What a lovely patio decorations.. I really admire your creativity and I'm sure like me my kids will love to see this in our patio. Thanks for such an inspiration Donna!

Thank you!
Nancy
Window Planet – Superior Quality Windows and DoorsNancy Davishttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-36582169086325011252014-12-05T08:51:46.410-05:002014-12-05T08:51:46.410-05:00oh I love your iron work and the kitty.....of cour...oh I love your iron work
and the kitty.....of courseSuzhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-47339366962399574462014-11-26T07:26:25.294-05:002014-11-26T07:26:25.294-05:00ils sont superbe belle journée Roseils sont superbe
belle journée
RoseRosehttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-1765251962807671922014-11-16T11:00:56.381-05:002014-11-16T11:00:56.381-05:00Glad to see you back blogging. Hope all is well.Glad to see you back blogging. Hope all is well.Chatelainehttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-52658036074829508352014-11-16T10:59:47.878-05:002014-11-16T10:59:47.878-05:00How lucky were we to have had Mayor Menino in offi...How lucky were we to have had Mayor Menino in office for so many years!

He was a role model for so many young people. His status as Mayor never changed him and he knew everyone in the City.

We will all miss his smiling face. RIP Mr. Mayor.Chatelainehttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-31464000895283640732014-11-16T10:57:44.568-05:002014-11-16T10:57:44.568-05:00I would be a nervous wreck too! I am sure she is v...I would be a nervous wreck too! I am sure she is very graceful like most cats but that perch is really high!

I did not know she was a Norwegian Forest Cat. She is beautiful!!!

I won't be long before she is climbing the Christmas tree!Chatelainehttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-39623175706170642202014-11-13T08:53:12.955-05:002014-11-13T08:53:12.955-05:00hello mon chat LOLA se mettait sur les poutr...hello
mon chat LOLA se mettait sur les
poutres de la chambre également
mais maintenant elle ne peut plus
trop d'Arthrose
votre porte est superbe
avec tous les découpes
très jolis décors
à bientôt
tendresse
edith (iris) Franceirishttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-74831881198950002912014-11-11T19:14:16.982-05:002014-11-11T19:14:16.982-05:00Wow! How in the world did Baby get up there?! Two ...Wow! How in the world did Baby get up there?! Two of my cats like to jump from a side table up onto the china cabinet (the other cat is too old now)...I wonder if they'd jump up onto a beam if they had the chance?!Melaniehttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-41778476647834178202014-11-10T09:55:45.466-05:002014-11-10T09:55:45.466-05:00I'd be nervous, too! That Baby - she's a b...I'd be nervous, too! That Baby - she's a bit of a scamp, isn't she?

xo
ClaudiaClaudiahttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-30021878230705534272014-11-08T19:45:41.131-05:002014-11-08T19:45:41.131-05:00Baby looks so content up there! I bet is also one ...Baby looks so content up there! I bet is also one of the warmest places in the house because hot air rises. Cats love a warm spot! What a gorgeous cat!Kc Whttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-19950913349783797332014-11-08T18:00:21.043-05:002014-11-08T18:00:21.043-05:00Good grief, I think that would really make me nerv...Good grief, I think that would really make me nervous! That is WAY up there!Donnahttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-71072734013121940102014-11-08T05:12:05.577-05:002014-11-08T05:12:05.577-05:00I would be nervous too, though she looks like a re...I would be nervous too, though she looks like a regal queen up there :) Deb @ Frugal Little Bungalowhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-91339479236349159002014-11-08T02:00:04.337-05:002014-11-08T02:00:04.337-05:00I'd be a nervous wreck if my cats had that bea...I'd be a nervous wreck if my cats had that beam to climb up onto! They would do it too just to see me squirm. Maureen Wyatthttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-25879672977758184952014-11-07T20:31:21.188-05:002014-11-07T20:31:21.188-05:00Hi!i haven't seen much from you in a while. ...Hi!i haven't seen much from you in a while. Was there a change? I so enjoy your posts and this one is no exception. And I love, love Baby's antics!Heidi Coltonhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-90044602410058049702014-11-07T15:58:58.639-05:002014-11-07T15:58:58.639-05:00Hi Donna....Lovely photos. Imagine that baby! Wh...Hi Donna....Lovely photos. Imagine that baby! What a little acrobat, climbing wayyyyyy up there. What a riot.

Hope your weekend is good, too. SusanSusanhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-47209935301497889662014-11-07T10:30:01.652-05:002014-11-07T10:30:01.652-05:00Looking at the second photo....how does she get up...Looking at the second photo....how does she get up there? I love it, my Mother had a cat who would jump on a tall book case and then jump on unsuspecting shoulders as they passed by.......Maryhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-47620756113927334732014-11-07T08:46:57.268-05:002014-11-07T08:46:57.268-05:00Loved your pictures of those high wire cats! But I...Loved your pictures of those high wire cats! But I would worry about falls too.
One year, our "Orangey" hopped up on the mantle on Christmas eve and systematically knocked down every single nutcracker while we laughed ourselves silly under the influence of several glasses of nice wine!
And I have often freaked out at the sound of an ominous "thump" when I'm home alone. My Charlie loves to climb the bookcase and push heavy volumes off one at a time!Jhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-38746206261688545452014-11-07T07:40:27.301-05:002014-11-07T07:40:27.301-05:00Awww...That is one sweet BABY. We had a Maine Coo...Awww...That is one sweet BABY. We had a Maine Coon and he also LOVED to be up in the air. He could stand beside the refrigerator and in one bound leap straight up on top of it. What a fun post here today- xo DianaNanaDianahttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-48561411921044481852014-11-07T05:02:16.207-05:002014-11-07T05:02:16.207-05:00The view through your FR windows really IS "e...The view through your FR windows really IS "enchanting"!Rebeccahttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-29215236092991431342014-11-04T15:26:22.892-05:002014-11-04T15:26:22.892-05:00Hi Donna...Looks like Mr. Menino earned all of the...Hi Donna...Looks like Mr. Menino earned all of the wonderful tributes he is receiving. Our newspaper today had a big write-up on him, too.

May he rest in eternal peace. SusanSusanhttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-34070044318413371542014-11-03T22:16:33.316-05:002014-11-03T22:16:33.316-05:00My sister lived in downtown Boston for many years ...My sister lived in downtown Boston for many years and thought every highly of the mayor. You wrote a lovely tribute to his good work. I enjoyed the pictures, reminding me of many visits. The Swan Boats are so enchanting!Jhttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-83142126426503316942014-11-03T21:45:25.921-05:002014-11-03T21:45:25.921-05:00What a heartfelt post. He sounds like a wonderful...What a heartfelt post. He sounds like a wonderful man. Blessings- xo DianaNanaDianahttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-15104497449938823912014-11-02T16:40:07.208-05:002014-11-02T16:40:07.208-05:00A lovely New England setting! Yes, that spring sce...A lovely New England setting! Yes, that spring scene did fade away far too rapidly for me too!
Our Halloween was ugly. Pouring rain and so windy that it blew horizontally. Mixed with snow too. Yuck. I keep worrying that this is a sign of what's to come. Boo! - and NOT in a "Halloween way!"Jhttp://firstname.lastname@example.com:blogger.com,1999:blog-59504869006627653.post-2376215587138504102014-11-01T12:17:45.454-04:002014-11-01T12:17:45.454-04:00Hello Donna - I have missed your posts! All our tr...Hello Donna - I have missed your posts! All our trees are bare here now. In fact, my husband is outside right now (probably freezing), cleaning out the gutters and leaf blowing. It's cloudy and cold and I know this is just the beginning of a loong winter. I said to hubby last night, "OK, I'm tired of the cold weather already! Let's fast-forward to April." Ha. I wish.Melaniehttp://email@example.com:blogger.com,1999:blog-59504869006627653.post-52521679962604516312014-11-01T10:20:26.975-04:002014-11-01T10:20:26.975-04:00What a difference in the seasons! I love photo co...What a difference in the seasons! I love photo comparisons like this. Hope you had a nice holiday!Donnahttp://firstname.lastname@example.com


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Anthony Mongiello Photographer
Matt Cali PhotographyPhotographer Male Los Angeles, California, US
Mayhem # 271485
About Me
I'm Matt, I'm a photographer from Seattle. I live in LA now and love it. I shoot headshots, fashion, editorial, commercial, weddings, portraits and street photography. There's a lot of creativity here which keeps me energized. The friends I've made personally and professionally mean the world to me and keep me motivated to be more creative. I'm here to meet fun, up beat creative people to work with, and collaborate on different projects.
I keep my rates reasonable, and my shoots fun. I do limited trades but open to it.
Lets talk soon.
Anthony Mongiello Photographer
Amy sc Model
Alyson Allegra Model
Arshiya Parmar Model
Cherissa Nichole Model
amber may Model
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Tognum backs new bid from Rolls
Tuesday 17 May 2011
Tognum's board is backing a sweetened €26-a-share offer from the car and truck maker Daimler and the engineer Rolls-Royce, marking a decisive step in the suitors' bid for control of the German engine-maker. The offer values Tognum at €3.4bn (£3bn), the equivalent of 11.3 times its recent annual core earnings.
The pair have also lowered the bid threshold from 50 to 30 per cent. A takeover will allow Rolls to expand its marine and diesel power business while Daimler will re-establish closer ties with a major buyer of its diesel truck engines, which Tognum retools for specialist purposes.
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text:
Astronomers Uncover One of the Youngest and Brightest Galaxies in the Early Universe
Hot and Cold in the M100 Galaxy
Scenarios for the Evolution of Asteroid Belts
March of Asteroids Across Dying Star
Powerful, Pulsating Core of Star
A Picture of Unsettled Planetary Youth
Infrared Rose
Is There Anybody Home?
Kepler-69 and the Solar System
Dusty Reflections in the Scorpion's Claws
Highlighting our Tiniest Neighbors
NGC 6744 -- A Sibling of the Milky Way
Birth of an Unusual Planetary System (Artist Concept)
Big Hole Revealed in Infrared
Ancient Galaxy Cluster Still Producing Stars
Slender Galaxy with Robust Black Hole
Diverse Group of Galaxy Types, NGC 3190 Field
The Mysterious Galactic Haze seen by Planck
Horsehead of a Different Color
Space Balls (Artist's Concept)
Tour of Planet with Extreme Temperature Swings
Ancient Supernova Revealed
A Vast Disk of Comets
Two Black Holes on Way to Becoming One (Artist's Concept)
The Invisible Dragon
Cluster of Stars in Kepler's Sight
NASA's Great Observatories Witness a Galactic Spectacle
Sloshing Star Goes Supernova
Ghostly Ring
Classic Galaxy with Glamour
Young Stars Emerge from Orion's Head
Steamy Solar System
Ultraviolet Extensions
The Homes of Quasars
Sedna Size Comparisons (Artist's Concept)
'Honey I Shrunk the Planetary System' (Artist Concept)
Weighing in on the Dumbbell Nebula
Black Hole Simulation
Evolution of a Supernova
Severe Exoplanetary Storm
Adding a New 'Color' to Palate of Cassiopeia A Images
Spitzer Digs Up Hidden Stars
Interacting Galaxies
Galaxy Evolution Explorer Spies Band of Stars
The Universe Comes into Sharper Focus
Solid as a Rock? Porosity of Asteroids
Spitzer's Sunflower Galaxy
The Sword of Orion


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Jaques Solomon Croquet MalletItem # HN-JA035
- Competition mallet designed for John Solomon
- Brass-ringed square head of Lignum Vitae
- English hickory octagonal handle with Takair grip
- Square mallet head: 9L x 2.25W x 2.25H inches
- Handle length: 37.5 inches; Weight: 3 lbs.
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Jaques Solomon Croquet Mallet
The traditional Solomon Croquet Mallet was originally designed for John Solomon, the greatest croquet player of our time. One of the most popular competition models, this mallet has a square head turned from Lignum Vitae, the hardest wood available. Brass rings at either end of the mallet add weight and protect against damage caused by miss-hits.Many professional croquet players prefer the narrower width of the square head as it makes play hoop shots easier. There may also be some advantage some


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The Collectables Cheats for iPhone - iPodHome / iPhone - iPod /
This page contains Cheats for The Collectables organized by sections for iPhone - iPod. The Collectables is a Action General game, made by DeNA Co., Ltd., released on Apr 20, 2014 and published by Crytek. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
- Developer:
The Collectables iPhone - iPod CheatsDeNA Co., Ltd.
- Publisher: Crytek
- Genre: Action General
- Release Date: Apr 20, 2014
- ESRB: Not Set
You can lead the whole group with an easy tap, or specific members by tapping them and directing their paths. Your soldiers will instantly fire at enemies that obstruct, however it is very important to put them into cover as frequently as you can to keep them from taking damage. To use a firecracker...From: DTFIFAMANAGER
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an The Collectables expert then please try to help others with their questions.
The Collectables - Coming Soon Trailer
- Dec 12, 2013, Views: 53
The Collectables - Episode 1: Pilot Gameplay
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HOME > Unan1mous
Tarah Smith wins $382,193 grand prize in Fox's 'Unan1mous' finale
In the end, all of Fox's remaining Unan1mous contestants finally agreed. Even the conniving, double-crossing Jonathan. Full Story
Fox reveals the identities of its 'Unan1mous' reality show contestants
Fox has revealed the identities of the nine contestants who will compete on Unan1mous, its new "open-ended" reality series that will premiere Wednesday, March 22 at 9:30PM ET/PT and air regularly in the network's highly coveted post-American Idol results show time period.
Fox announces new 'Unan1mous' reality show to premiere March 22
Well, it's not the return of either Forever Eden or its Paradise Hotel predecessor that some diehard reality fans have continued to hope for, but Fox has announced that it will air one non-fixed length reality series this spring -- a new show called Unan1mous.
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Personalized New York Sergeant Badge Keychain w/ Your Number & Department
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This authentic looking badge, which is made in our New York City Factory, is available in
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These make for the perfect gift for any and all occasions, especially for graduation or retirement.
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"This was such a great idea! I shopped stores and the internet to find out who would have the most reasonable price for the best quality. I'm glad I ordered my wife's first Mother's Day gift from PicturesOnGold.com. It was a big hit."
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"Love the lip prints and photo of my mother and daughter. This will mean the world to her as they were very close. Thanks so much for your time and understanding you gave me in this process. Your work is amazing. Telling all my friends about you"
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"I have never written a testimonial before, but I was so impressed with the quality of workmanship and speed of service from PicturesOnGold.com that I felt compelled to write. Last year I had been looking for a very special Christmas gift for my sister-in-law in memory of her son who passed away just four months earlier. I saw your website for photo pendants advertising "Guaranteed for Christmas", but to be honest was skeptical ordering it so late. I placed my order online Tuesday 12/7 and was amazed to receive my delivery by Thursday – just two days later. The pendant really is exquisite; it captured the photo of my nephew beautifully and the special message was engraved on the back. My sister-in-law has never taken it off and said she is going to cherish it forever. I have shared your website with many friends and family.
Wishing you All a Joyous Christmas,
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"I had to write in to tell you how pleased I am with my purchase. The quality is amazing and the color photo is crystal clear - I will definitely be ordering from you again. I also want to thank you for making my order a priority. I was concerned that I would not receive my pendant in time and Daniel assured me that it would be ready. He also helped me save money by suggesting I it ship ground (I was going to Next day the item). I received my order 3 days ahead of what I needed and I am extremely pleased! I will be spreading your name around to all my friends and family! Thank you for helping to make my mothers birthday extra special!"
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"I highly recommend this site to everyone, the people were soo friendly and helpful and the service was unbeatable... I will never use another jeweler again"
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"I am 100% satisfied with my purchase. I recived it in 2 days and it is absolutely gorgeous. I will tell everyone I know about u and how wonderful you are. I look forward to doing business with u very soon. Thank you for such wonderful service and gorgeous jewelry."
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"The only thing I can say is that your website comes nowhere near portraying the beauty and the quality of your work...but your customer testimonials certainly do. I make a bet that you guys love your work because you've obviously touched a lot of people and made a positive difference in their lives. Thank you so much for your part in making this a special Christmas day for me.
Kindest regards,
Donna S."
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"I have had a great experience with this company. I am so happy with the product I received and how fast I received it. I have been looking to get a certain charm for my 15 year old son for about two years. I was looking for a number in sterling silver. I have seen quite a few different ones over the two years but they were never what I wanted to get him and I was never happy with them. I have ordered and sent back at least four of them. I by mistake stumble upon your website. And I am so grateful I did. You had exactly what I wanted to get him. I am so pleased. I just know he will love it. I am so grateful. I am also so grateful for the sped of processing my order than making it and getting it to me. When I ordered pre-made numbers from jewelry stores it took anywhere from 2 weeks to a month before I received it. But with you I received it in 3 day total. I ordered it Wednesday and got it Friday. I was amazed. All I want to say is thank you so much for helping me make my son happy this Christmas. It means a lot to me. Thank you again. And marry Christmas."
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"I have probably ordered one or more of most everything you sell and I am 100% happy with everything I am no buying this years birthday presents for my family from you. to anyone wanting to know about this company there wonderful products are beautiful shipping is fast workman ship perfect I will be back for a lot more Items thank you for such great service.
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Animated LeBron
"The LeBrons" (you know, animated LeBron) has arrived
Apr 6, 2011, 12:39 PM EST
"The LeBrons" — now with een more LeBron! Below is the first episode of The LeBrons, the animated spinoff of a commercial. Because if there is one thing we need more of its spin offs of commercials, like turning the GEICO caveman into a sitcom. How'd that work out? But this is going to be…
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Cadbury Milk Chocolate Finger Tin (228g / 8 oz)Cadbury Milk Chocolate Finger Tin contains delicious Cadbury chocolate fingers have a biscuit center coated in layers of chocolate. Cadbury Chocolate Fingers in this festive tin makes a great gift for the holidays. Learn More
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Jacobs Bourbon Creams (200g / 7oz)
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Lutheran High School of San Antonio has named Patrick Maynard its new head of school. Maynard comes to LHS San Antonio after serving as the Principal, Athletic Director and Technology Director at Concordia High School (CHS) in Austin and as an Admissions Counselor at Concordia University Texas.
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Travel Blogs from Alcala la Real
... walking the Camino we had little idea of what we where taking on, no guide book, little walking experience, unfit and clueless. We had the time, the inclination and possibly looking for answers. One week later we miss the Camino - we miss waking to a new experience and new people, different sights, sounds and smells. We miss thinking of nothing but walking, ...
Day 32 1040 k
... station. Say farewells to girl on desk as we are now friends. Off we go, I have best seat on dashboard wheeee . A couple of hours on we stop for refreshment, back in car, dead as a doorpost., She grabs 2 Guys and asks for a push , me and Jim are away engine roaring, she has to run and jump - we are now heading for Madrid. You should have seen us just around ...
Twin Peaks
When we return to Spain we join a fantastic walking group. Thanks to the efforts of Roger and Bill we have enjoyed multiple scenic hikes in the mountains around Alicante. Their frequent scouting walks have helped them to organize many wonderful circular routes that allow us unbelievable views and some good exercise as well. Today's walk was double the effort and just as much fun! We walked on ...
Hiking in Xorret de Cati
... the ridges. We could see some signs of the recent rainfall, there was some erosion and a few puddles of water...generally a rare sight in this part of Spain. Eventually we came to an old ruin where we stopped for lunch. Then we finished our hike, climbing back along the side of the ridge to complete the circle and return to our cars.
It was a great way to restart our walking program. Here are some photos of the day.
La Plaza de Toros
... took a sword from an assistant at the side of the ring. He approached the bull, who was standing still, probably exhausted, and with much concentration on his face, the toreador, with a single stab, plunged the sword into the bull's neck and a fountain of blood spurted out. The kids covered their faces. None of us had expected it. In the film the crowd cheered and the matador faced them with his arms outstretched, while in the background the bull crumpled to his knees, dark ...
Other places to stay in Alcala la Real
Hotel TorrepalmaC/Conde de Torrepalma 2, Alcala la Real | 3 star hotelfrom $77


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text: Open Access Review Review: Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain by Thomas Heinbockel, Ze-Jun Wang and Patrice L. Jackson-Ayotunde Pharmaceuticals 2014, 7(12), 1069-1090; doi:10.3390/ph7121069 - published 17 December 2014 Show/Hide Abstract Abstract: In an ongoing effort to identify novel drugs that can be used as neurotherapeutic compounds, we have focused on anilino enaminones as potential anticonvulsant agents. Enaminones are organic compounds containing a conjugated system of an amine, an alkene and a ketone. Here, we review the effects of a small library of anilino enaminones on neuronal activity. Our experimental approach employs an olfactory bulb brain slice preparation using whole-cell patch-clamp recording from mitral cells in the main olfactory bulb. The main olfactory bulb is a key integrative center in the olfactory pathway. Mitral cells are the principal output neurons of the main olfactory bulb, receiving olfactory receptor neuron input at their dendrites within glomeruli, and projecting glutamatergic axons through the lateral olfactory tract to the olfactory cortex. The compounds tested are known to be effective in attenuating pentylenetetrazol (PTZ) induced convulsions in rodent models. One compound in particular, KRS-5Me-4-OCF3, evokes potent inhibition of mitral cell activity. Experiments aimed at understanding the cellular mechanism underlying the inhibitory effect revealed that KRS-5Me-4-OCF3 shifts the concentration-response curve for GABA to the left. KRS-5Me-4-OCF3 enhances GABA affinity and acts as a positive allosteric modulator of GABAA receptors. Application of a benzodiazepine site antagonist blocks the effect of KRS-5Me-4-OCF3 indicating that KRS-5Me-4-OCF3 binds at the classical benzodiazepine site to exert its pharmacological action. This anilino enaminone KRS-5Me-4-OCF3 emerges as a candidate for clinical use as an anticonvulsant agent in the battle against epileptic seizures. Open Access Review Review: Adoptive Immunotherapy for Hematological Malignancies Using T Cells Gene-Modified to Express Tumor Antigen-Specific Receptors by Hiroshi Fujiwara Pharmaceuticals 2014, 7(12), 1049-1068; doi:10.3390/ph7121049 - published 15 December 2014 Show/Hide Abstract Abstract: Accumulating clinical evidence suggests that adoptive T-cell immunotherapy could be a promising option for control of cancer; evident examples include the graft-vs-leukemia effect mediated by donor lymphocyte infusion (DLI) and therapeutic infusion of ex vivo-expanded tumor-infiltrating lymphocytes (TIL) for melanoma. Currently, along with advances in synthetic immunology, gene-modified T cells retargeted to defined tumor antigens have been introduced as "cellular drugs". As the functional properties of the adoptive immune response mediated by T lymphocytes are decisively regulated by their T-cell receptors (TCRs), transfer of genes encoding target antigen-specific receptors should enable polyclonal T cells to be uniformly redirected toward cancer cells. Clinically, anticancer adoptive immunotherapy using genetically engineered T cells has an impressive track record. Notable examples include the dramatic benefit of chimeric antigen receptor (CAR) gene-modified T cells redirected towards CD19 in patients with B-cell malignancy, and the encouraging results obtained with TCR gene-modified T cells redirected towards NY-ESO-1, a cancer-testis antigen, in patients with advanced melanoma and synovial cell sarcoma. This article overviews the current status of this treatment option, and discusses challenging issues that still restrain the full effectiveness of this strategy, especially in the context of hematological malignancy. Open Access Review Review: Role of Microglial M1/M2 Polarization in Relapse and Remission of Psychiatric Disorders and Diseases by Yutaka Nakagawa and Kenji Chiba Pharmaceuticals 2014, 7(12), 1028-1048; doi:10.3390/ph7121028 - published 25 November 2014 Show/Hide Abstract Abstract: Psychiatric disorders such as schizophrenia and major depressive disorder were thought to be caused by neurotransmitter abnormalities. Patients with these disorders often experience relapse and remission; however the underlying molecular mechanisms of relapse and remission still remain unclear. Recent advanced immunological analyses have revealed that M1/M2 polarization of macrophages plays an important role in controlling the balance between promotion and suppression in inflammation. Microglial cells share certain characteristics with macrophages and contribute to immune-surveillance in the central nervous system (CNS). In this review, we summarize immunoregulatory functions of microglia and discuss a possible role of microglial M1/M2 polarization in relapse and remission of psychiatric disorders and diseases. M1 polarized microglia can produce pro-inflammatory cytokines, reactive oxygen species, and nitric oxide, suggesting that these molecules contribute to dysfunction of neural network in the CNS. Alternatively, M2 polarized microglia express cytokines and receptors that are implicated in inhibiting inflammation and restoring homeostasis. Based on these aspects, we propose a possibility that M1 and M2 microglia are related to relapse and remission, respectively in psychiatric disorders and diseases. Consequently, a target molecule skewing M2 polarization of microglia may provide beneficial therapies for these disorders and diseases in the CNS. Open Access Article: Involvement of the Antioxidant Effect and Anti-inflammatory Response in Butyrate-Inhibited Vascular Smooth Muscle Cell Proliferation by Omana P. Mathew, Kasturi Ranganna and Shirlette G. Milton Pharmaceuticals 2014, 7(11), 1008-1027; doi:10.3390/ph7111008 - published 10 November 2014 Show/Hide Abstract Abstract: Epigenetic mechanisms by altering the expression and, in turn, functions of target genes have potential to modify cellular processes that are characteristics of atherosclerosis, including inflammation, proliferation, migration and apoptosis/cell death. Butyrate, a natural epigenetic modifier and a histone deacetylase inhibitor (HDACi), is an inhibitor of vascular smooth muscle cell (VSMC) proliferation, a critical event in atherogenesis. Here, we examined whether glutathione peroxidases (GPxs), a family of antioxidant enzymes, are modulated by butyrate, contributing to its antiproliferation action on VSMC through the regulation of the inflammatory response by using western blotting, immunostaining methods and activity assay. Treatment of VSMC with butyrate not only upregulates glutathione peroxidase (GPx) 3 and GPx4, but also increases the overall catalytic activity of GPx supporting involvement of antioxidant effect in butyrate arrested VSMC proliferation. Moreover, analysis of the redox-sensitive NF-κB transcription factor system, the target of GPx, reveals that butyrate causes downregulation of IKKα, IKKβ, IkBα and NF-κBp65 expression and prevents NF-κBp65 phosphorylation at serine536 causing inhibition of the expression NF-κB target inflammatory genes, including inducible nitric oxide synthase, VCAM-1 and cyclooxygenase-2. Overall, these observations suggest a link between the antioxidant effect and anti-inflammatory response in butyrate-arrested VSMC proliferation, accentuating the atheroprotective and therapeutic potential of natural products, like butyrate, in vascular proliferative diseases. Open Access Review Review: Recommendations for Probiotic Use in Humans—A 2014 Update by Martin H. Floch Pharmaceuticals 2014, 7(10), 999-1007; doi:10.3390/ph7100999 - published 10 October 2014 Show/Hide Abstract Abstract: Probiotics have gained worldwide use during the last two decades. However, which probiotic to use in which clinical condition has remained confusing in some clinical conditions. We convened a workshop at Yale in conjunction with Harvard in 2005, inviting a spectrum of probiotic authorities to discuss and reach conclusions on recommendations for use in common clinical conditions; the workshop was reconvened again in 2008 and in 2011. Each time the group of authorities was enlarged and varied depending on research studies. This article lists the recommendations updated from 2011 and is amended to bring it up to date in childhood and adult diarrhea, antibiotic-associated diarrhea, necrotizing enterocolitis, inflammatory bowel disorders, irritable bowel syndrome, allergic disorders, and radiation enteritis pending our 4th Triennial Yale/Harvard workshop to be convened in 2015. Open Access Commentary: Ferric Citrate Hydrate as a Phosphate Binder and Risk of Aluminum Toxicity by Ajay Gupta Pharmaceuticals 2014, 7(10), 990-998; doi:10.3390/ph7100990 - published 26 September 2014 Show/Hide Abstract Abstract: Ferric citrate hydrate was recently approved in Japan as an oral phosphate binder to be taken with food for the control of hyperphosphatemia in patients with chronic kidney disease (CKD). The daily therapeutic dose is about 3 to 6 g, which comprises about 2 to 4 g of citrate. Oral citrate solubilizes aluminum that is present in food and drinking water, and opens the tight junctions in the intestinal epithelium, thereby increasing aluminum absorption and urinary excretion. In healthy animals drinking tap water, oral citrate administration increased aluminum absorption and, over a 4-week period, increased aluminum deposition in brain and bone by about 2- and 20-fold, respectively. Renal excretion of aluminum is impaired in patients with chronic kidney disease, thereby increasing the risk of toxicity. Based on human and animal studies it can be surmised that patients with CKD who are treated with ferric citrate hydrate to control hyperphosphatemia are likely to experience enhanced absorption of aluminum from food and drinking water, thereby increasing the risk of aluminum overload and toxicity. Latest articles -


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Halle Berry on Her Past: Traumatic Childhood 'Damaged Me'
The Oscar winner, 44, opened up to CNN recently about what motivates her to work with an organization that supports women who escape violent homes.
Berry recalls being terrified that her violent dad, who physically abused her mom, would turn on her, adding, "I think I've spent my adult life dealing with the sense of low self-esteem that sort of implanted in me. Somehow I felt not worthy." As incredible as that sounds coming from a highly paid, highly photogenic movie star, she explains, "Before I'm 'Halle Berry,' I'm little Halle....a little girl growing in this environment that damaged me...I've spent my adult life trying to really heal from that."
Of her dedication to supporting others trying to escape domestic violence -- including frequent volunteering at Jenesse Center, a Los Angeles shelter, and helping to renovate apartments for women leaving abusive relationships -- she says, "I have a spot in my soul that understands the devastation that this causes a family." Watch Berry opening up more about her past in this CNN clip:
- Filed under:
- Movie News
- Sunday 26 DecemberBy mizmarymay
You've had MAN years to " LET GO AND LET GOD HAVE IT".....IF you are still meserable, It's because you Chose to be.
- Sunday 26 DecemberBy steven
Hey Harlow
Your name should be shallow because that is what you and the other haters on this board are.
- Sunday 26 DecemberBy kjhnvbdfhn
Did she threaten to run away from him and keep him from his kids, Halle? Was she a psycho? Did she deserve his justified hatred? ,My boyfriend and i both think so ...He is almost 11year older than me .i met him via uniform'edmeet.c 'oma nice place for s'ee'king Army, Navy, Mari'nes, Air Force, Police Force and their admires.just love it
- Sunday 26 DecemberBy wbillevans
There is an ancient saying that goes something like this: " Life is full of pain, how much you suffer is up to you." I applaud Halle for using the experience to help others. It is often a mistake to keep bringing the past up and reliving it again and again. In that regard Halle needs to find a way to "let this go".
- Monday 27 DecemberBy cylint
Wanna know where people go to snag a r ich si ngle rel-ations-hip, say, Just for future reference? "we alt hy Central"? "San Carlos" ? or "San Francisco"?
*** CelebMingle C 0/om *** is the real place that is packed with them. ;)
★★★★★★ ;)
- Monday 27 DecemberBy DaynaHigh Rank Vote downVote upReport this
MIZMARYMAY - what are "MAN" years?
- Tuesday 28 DecemberBy wufbdfbdfny
WAW WAW WAW....What a WHINER. shes had the best of the best, and cant keep anyone stable in her life. What about the VICTIMS she has created from her driving!!! and her life in general. What a worthless piece of crap.....Beauty is truly only skin deep. Your a waste of oxygen Girl! WILL NEVER BUY ANYTHING YOU ENDORSEI love this , So does My boyfriend .he is almost 11year older than me .i met him via agelesskiss.c 'om a nice place for seeking age le ss love.which gives you a chance to make your life better and open opportunities for you to meet the attractive young girls and treat you like a king. Maybe you wanna check it out or tell your friends.. Just love it
- Sunday 26 DecemberBy karen
we are sick of hearing about this person childhood, she needs help, it is award season and now the bull is being sold, for attention.
- Sunday 26 December
you may be the sick one.
- Sunday 26 DecemberBy Dawn
I agree, everytime there is a movie on to promote, Halle falls into her "Oh woeth me" drama.
- Sunday 26 DecemberBy Shimmer
hey--responder 'dawn'. it goes like this: "Woe is me."
woeth? hahahaaa..dummy!
- Tuesday 28 DecemberBy g
If I were ever to see Halle walking down the street I would see a beautiful BI-RACIAL woman. Halle does not in any way look like your typical Black woman. Halle is mixed with black and white and should be embracing both of her cultures. She actually owes her stunning looks to being blessed with both genes. I seriouly doubt if she were all of one of either that she would have inherited the beautiful features she has. Be proud of your mixed heritage Halle. It's about time you did!
BTW....I am a proud BI-RACIAL!!!
- Sunday 26 DecemberBy Charlie
Her mother was abused by her black father yet she plays herself off as black.
- Tuesday 28 DecemberBy Redv14
So,are you saying that she is not black? What happened to the rule in the racist USA that one drop of black blood makes you black? Have you suspended that rule? If so, alert the media so that it will be known to everyone from now on that mixed race people can now identify themselves as white.
- Sunday 26 DecemberBy el
So, Charlie, What's your point?
- Sunday 26 DecemberBy Nicole
Plays herself off as black? Charlie, I'd say you play yourself off as human, which you clearly are not. Halle Berry is a lovely, talented actress who is being honest about how living in an abusive home as a child has effected her as an adult. Maybe you don't like what she says because you are guilty of being an abuser yourself.
- Monday 27 DecemberBy Pamela
her father's color has nothing to do with it whatsoever.. GET OFF THE DAMN COLOR SH*T........It's old and makes you look ignorant
- Monday 27 DecemberBy Ginger
Plays herself as black? Look at her. You see her walking down the street, do you see a white woman? No, you see a black woman. Her actual racial make up doesn't matter.
- Tuesday 28 DecemberBy hislonv
She is only black when it suits her to be so. She keeps bringing up race like when she won the OSCAR. Now she brings up her past as if she is different from many many others who could tell similar stories, but choose to put those memories behind themselves.
She needs to do the same. I don't hate her, I am just tired of her crap.
- Sunday 26 DecemberBy Glad to
You are so snide and a hater. People are abused and they have the right to say it no matter when. They own the experience and we love you Hallie.
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Ralph Lauren Black Label
Men's Ralph Lauren Black Label Trim Fit Navy Stretch Wool Suit
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Sharp microchecks pattern an Italian-crafted stretch-wool suit featuring a handsome two-button, notch-lapel jacket. Slim, high-waisted trousers with fit-perfecting buckle tabs on the belt-free waist complete the formal style. Color(s): navy multi. Brand: RALPH LAUREN BLACK LABEL. Style Name: Ralph Lauren Black Label Trim Fit Navy Stretch Wool Suit. Style Number: 427459.See More Details


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Doing It Right for Family
by Mike Stanz
posted Jun 4 2014 3:00PM
Phil Collins – the drummer who started with Genesis and later had a solo career of his own in the 80's – made a special appearance last week at a show for his son's friends.
Phil announced his retirement in 2011, citing back issues and more from years of playing hard on the road, but when family calls, you come back, right? He sang "In The Air Tonight" and "Land of Confusion."
By the way, his son is a middle-schooler at Miami Country Day. Phil is 63 years old.
Hey, there's nothing wrong with being a late bloomer, right?
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State lawmakers want local governments to publish their budgets where no one looks.
The 2015 edition of Business & Industry will focus on the legends who have helped build Elkhart County, as well as the new generation of leaders picking up the mantle.
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Import Purchasing Agent Jobs in Texas
7 Texas Import Purchasing Agent jobs found on Monster.Jobs 1 to 7 of 7
Igloo Houston, TX, 77020
Founded in 1947, Texas-based Igloo Products Corp. is today an international designer, manufacturer and marketer of outdoor products that make the outdoor experience more accessible and fun. So whether it's on the water, near the water, on the trail, on the hunt, in the mountains or just around the house for family fun, Igloo goes where you go and makes the experience better. We are specialists fro...
Position Description The Import Manager is responsible for an overall team of 8 people. This role is critical in that it is our largest and highest revenue producing department. Candidates must have strong leadership skills, managing department staffing and enforcing company policies and procedures. DUTIES & RESPONSIBILITIES: Work with the General Manager to evaluate staffing needs, conduct int...
Position Description The Import Supervisor is responsible for maintaining their own desk as well as taking on additional responsibilities within the department. They will have strong leadership skills, help manage department staffing and enforce company policies and procedures. The Import Team Supervisor will have extensive import operations background and will work closely with the Import Operat...
Position: Inventory Analyst/Customer Service Rep. Reports To: Inventory/Customer Service Manager Location: Houston, TX http://castlebrandsinc.com/ Castle Brands Inc., a producer, importer, and marketer of alcoholic beverages has an opening in its Houston location for an Inventory Analyst to assist with the domestic sales and inventory transactions. The majority of responsibility consists of wo...
Our client is currently seeking a Expeditor. Track all Purchase Orders (POs). Act immediately after the issuance of orders / Letters of Intent to the Supplier for which expediting is required. Follow-up on expediting matters related to Company purchased goods; closely follow-up with Vendors upon PO placement to ensure delivery of items on time.Manage penalties in case of delays in PO obligations...
Honeywell China, TX
Description Customer Service Representative - Catalysts, Adsorbents & Specialties An excellent career opportunity is currently available for a Customer Service Representative within UOP's Catalysts, Adsorbents & Specialties (CA&S) organization located in Mobile, AL. This position will play a key and integral role in the timely and effective execution of all aspects of the customer order fulfillm...
First American Financial Corporation Houston, TX
Job Description: First American Title Insurance Company's National Commercial Services division provides single-point service for simple to multi-property/multi-state national commercial real estate transactions. One of the largest title insurers in the nation, First American offers title services through its direct operations and an extensive network of agents throughout the United States and ab...
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Related Job Titles
Finance Career Tools
Import Purchasing Agent
$25,728.00 - $80,000.00
Typical Salary for Import Purchasing Agent in Texas
(73 Respondents)
Source: Monster.com Careerbenchmarking Tool
Education / Training
Some College Coursework Completed
High School
(47 Respondents)
Source: Monster.com Careerbenchmarking Tool
Import Purchasing Agent
Obtains materials from foreign suppliers by tracking conditions in foreign locations; identifying and qualifying suppliers; negotiating contracts; maintaining records.
Rate of Growth
2.90 %
Size of Industry in 2006:
Source: Bureau of Labor Statistics, May 2006
Related Skills
Customer Service
Decision Making
International Relations
Inventory Control
Related Duties
Locates foreign suppliers by researching producers; visiting facilities; discussing production, price, quality, service, and payment terms.
Analyzes price proposals, financial reports, and other data and information to determine reasonable prices.
Popular Import Purchasing Agent Articles
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text:
The Wisconsin Warriors U14 baseball team will be having tryouts for it's 2015
season. Come join the team that plays competitive regular season
baseball games against quality teams throughout southeastern Wisconsin. We have been selected by The Rock to be 1 of 8 teams to play in their league in 2015. The Wisconsin Warriors were 1 of 3 teams to call The Rock their home field this past 2014 season. Next year will be even better playing all league games at the state of the art facility "The Rock"
Open tryouts for the team will be held Saturday August 2nd at Froemming Park in Franklin. Tryouts will be from 9-11am. Selected players will join the team to play in the first ever U14 Rock Baseball League. We will also play in a minimum of 6 weekend tournaments. With two tournaments to be played at The Rock. The season consists of 40-50 games with all league games at The Rock.
To be eligible, players cannot turn 15 years of age prior to May 1st, 2015.
Please bring bat, glove, helmet and spikes.
Please contact Jeff Mallas at firstname.lastname@example.com to obtain registration
and waiver form.
Froemming Park
8801 S 51st St
Franklin WI
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