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News Releases
AACR CEO Discusses the Global Status of Cancer at Seminar in Turin, Italy
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PHILADELPHIA — Margaret Foti, PhD, MD (hc), chief executive officer of the American Association for Cancer Research (AACR), spoke at the Institute for Cancer Research and Treatment (IRCC) in Turin, Italy, Tuesday, Nov. 25. Her lecture was titled "Reflections on the Global Cancer Research Landscape."

The audience included both senior and junior researchers at the IRCC, a nonprofit scientific and clinical institution in Turin that specializes in all areas of cancer research, especially translational cancer research. Its mission is to fight cancer through understanding the basics of the disease, offering state-of-the-art diagnostic and therapeutic services, and leveraging the interface between molecular biology and medicine.

Foti's comprehensive presentation covered three main points: the global status of cancer, the progress and challenges facing the cancer field, and what the AACR is doing to address global cancer incidence and mortality. Advances in cancer research, she explained, have led to cures for a number of different cancers, a higher quality of life for cancer survivors, and an extension in the lives of patients whose cancer cannot be cured. Yet the global cancer burden will continue to rise unless cancer becomes a global priority, with governments and the general public committing to more funding, education, and improvements in regulatory science and policy. Foti emphasized these points by presenting data on cancer incidence and mortality in the world, Europe, and Italy. Major increases in incidence and mortality from cancer are projected to rise significantly by 2035, unless we stem the tide of this complex set of diseases.

Foti also discussed the importance of collaborations in tackling the toughest problems in cancer. With more than 35,000 members in 97 countries, the AACR has made collaboration a high priority, both in the United States and internationally. In October 2014, the organization opened its first satellite office outside the United States in Shanghai, China, with the goal of developing collaborations to maximize progress in the Asia Pacific region and around the world. Further, as the Scientific Partner of Stand Up To Cancer (SU2C), the AACR collaborates with SU2C and cancer research organizations across the globe in the oversight of a number of meritorious research grants. The AACR also partners with international organizations to host scientific meetings and workshops, including the prestigious series of annual meetings on Molecular Targets and Cancer Therapeutics held along with the U.S. National Cancer Institute (NCI) and the European Organisation for Research and Treatment of Cancer (EORTC).

This seminar is the latest event in Foti's longstanding relationship with the Italian cancer research community. In 2010, Foti was awarded the first Margaret Foti Award, established by the University of Catania PhD Oncology Program and the Italian League Against Cancer of Catania. She received an honorary doctorate in medicine and surgery from the University of Rome La Sapienza in 2003, a second honorary doctorate in medicine and surgery from the University of Catania in Sicily in 2008, and the Italian League Against Cancer Commendation. In 2012, she was given honorary citizenship by the mayor of Riposto, Italy.

Hookah Smoke Exposure Doubles Dangerous Benzene Uptake
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PHILADELPHIA — Hookah smokers and nonsmokers exposed to hookah smoke at social events in hookah lounges had significant increases in uptake of benzene, a substance associated with an increased risk for leukemia, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Hookah tobacco smoking involves the use of burning charcoal that is needed to heat the hookah tobacco to generate the smoke that the smoker inhales," said Nada Kassem, DrPH, MS, RN, MCHES, associate director at the Center for Behavioral Epidemiology and Community Health at San Diego State University. "In addition to inhaling toxicants and carcinogens found in the hookah tobacco smoke, hookah smokers and nonsmokers who socialize with hookah smokers also inhale large quantities of charcoal combustion-generated toxic and carcinogenic emissions."

Urine levels of S-phenylmercapturic acid (SPMA), a metabolite of benzene, were more than fourfold higher in hookah smokers and twofold higher in nonsmokers after attending a hookah-only smoking social event at a hookah lounge. Levels of SPMA were also significantly increased in hookah smokers after attending a hookah-smoking event in a private home.

"Because there is no safe level of exposure to benzene, our results call for interventions to reduce or prevent hookah tobacco use, regulatory actions to limit hookah-related exposure to toxicants including benzene, and include hookah smoking in clean indoor air legislation," Kassem added.

Kassem and colleagues analyzed the levels of SPMA in the urine of 105 hookah smokers and 103 nonsmokers. They obtained urine samples the morning of and the morning after participants attended a hookah-only smoking event at a hookah lounge or a private home.

Uptake of SPMA in hookah smokers increased 4.2-fold after smoking hookah tobacco at a social event at a hookah lounge and increased 1.9-fold after smoking hookah tobacco in a private home. Additionally, nonsmokers' uptake of SPMA increased 2.6-fold after attending a social event in a hookah lounge. However, nonsmokers had similar levels of SPMA before and after attending hookah events in a private home. According to Kassem, pre- and postevent levels were similar because nonsmokers' uptake of benzene before the private hookah event was as high as the levels found in nonsmokers after attending the hookah event in hookah lounges, possibly indicating chronic exposure to benzene.

"In contrast to what is believed, hookah tobacco smoking is not a safe alternative to smoking other forms of tobacco," Kassem said.
The study was supported by the American Cancer Society and Flight Attendant Medical Research Institute. Kassem declares no conflicts of interest.

Genes and Sun Behaviors During Childhood May Play Large Role in Future Melanoma Risk
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PHILADELPHIA — A longitudinal study established a link between different ultraviolet (UV) exposure measures in children, such as the number of waterside vacations or sunburns, and biomarkers of melanoma risk, such as the number of freckles or moles that develop during childhood, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Early-life UV exposure that confers risk for melanoma also plays a role in development of moles or melanocytic nevi, which can be both a biomarker for melanoma risk and occasionally an immediate precursor," said Neil Box, PhD, investigator at the University of Colorado Cancer Center and assistant professor in the Department of Dermatology at the CU School of Medicine in Denver.

The study showed that children with certain combinations of the blue eye-color gene variant and genetic variants that cause red hair are particularly susceptible to the formation of freckles and moles as they take waterside vacations early in life.

"Our research demonstrates that longitudinal studies are a powerful way to find and characterize gene-environment interactions," Box said. "These findings are an important step toward identifying high-risk groups for melanoma based on genotype and sun exposure history.

"Our data could potentially help produce refined guidelines or recommendations for UV exposure behaviors in genetically high-risk children," Box added.

Box and colleagues used DNA samples and information about sun-behavioral patterns from 477 non-Hispanic or Hispanic white children to evaluate the effect of different levels of sun exposure on mole and freckle formation in relation to genetic factors known to be associated with melanoma.

Following the children's behavior from 2004 to 2008, the researchers discovered that the number of moles and freckle density increased among the children in each successive year. Additionally, total number of sunburns, waterside vacations, and chronic sun exposure increased each year. All of the measures of sun exposure contributed to increased freckle counts, and cumulative chronic UV exposure was a major driver of freckle development.

"We also found that children who are homozygous for the major blue eye-color gene variant are particularly susceptible to formation of moles as they take more waterside vacations in early life," Box said. "Those kids with certain combinations of the blue eye-color variant and genetic variants that cause red hair color were also more likely to have larger moles as they sustained more sunburns."

The study also demonstrated for the first time that children who have particular red hair color gene variants display significantly more freckles as they experience more waterside vacations.

According to Box, the results of this study start to identify specific behaviors that can be changed in children who are at high risk for melanoma in later life.

The study was conducted by the Colorado Kids Sun Care Program research team and was supported by grants from the National Institutes of Health. Box declares no conflicts of interest.

Stand Up To Cancer and the Dutch Cancer Society Form an International Dream Team to Improve Early Detection of Colorectal Cancer
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PHILADELPHIA — Stand Up To Cancer (SU2C) and the Dutch Cancer Society, KWF Kankerbestrijding (KWF), along with the American Association for Cancer Research (AACR), SU2C's Scientific Partner, announced today the formation of an international Dream Team of top research scientists with the goal of improving early detection of colorectal cancer, currently the world's fourth-leading cause of cancer death.

"Too many cases of colon cancer escape detection until the disease is in its advanced stages," said Arnold J. Levine, PhD, professor at the Institute for Advanced Study in Princeton, New Jersey, and the Rutgers Cancer Institute of New Jersey in New Brunswick, and co-chair of the selection committee. "Better tests are needed to help detect colon cancer in its early stages when it can be more successfully treated."

The project, titled SU2C-KWF Molecular Early Detection of Colorectal Cancer (MEDOCC), will be funded by a Sta Op Tegen Kanker ("Stand Up To Cancer" in Dutch) Dream Team Translational Cancer Research Grant for 6 million euros (approximately $7.6 million) over four years.

"This collaborative research works very well with the Dutch national colorectal population-screening program, which will provide the Dream Team with 10,000 patients," said Hans Clevers, MD, PhD, a professor at the Hubrecht Institute in Utrecht, the Netherlands, president of the Royal Netherlands Academy of Arts and Sciences, and a co-chair of the selection committee. "Funding from the SU2C-KWF partnership can promote the development of new technologies in diagnostic and prognostic testing that will make real differences in patients' lives."

Gerrit A. Meijer, MD, PhD, professor of pathology at VU University Medical Center in Amsterdam, will serve as leader of the SU2C-KWF Dream Team, with Victor E. Velculescu, MD, PhD, professor of oncology and pathology at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center in Baltimore, serving as co-leader. Meijer will continue as team leader after he moves to the Netherlands Cancer Institute in early 2015.

"We believe that we can reduce death from colorectal cancer by providing a more accurate screening test as well as a disease recurrence test that will be cost-effective and simple for the patient," said Meijer. "Much of the basic work has already been done, so we hope to move rapidly toward perfecting the tests and demonstrating their safety and effectiveness."

The team will focus on validation of highly sensitive molecular tests that detect cancer-specific molecules, called biomarkers, in stool samples, indicating the presence of cancer or precancerous lesions in the colon or rectum. The team will also develop a blood test that will fill a gap in treatment of early-stage colorectal cancer by helping to identify patients who can benefit from chemotherapy after surgery.

"Our work will translate scientific breakthroughs on new 'liquid biopsy' technologies for noninvasive detection of cancer to improve outcomes for colorectal cancer patients," Velculescu said. "The international collaboration will take advantage of the best science on both sides of the Atlantic."

The MEDOCC project is the third collaboration between SU2C and KWF. Teams previously announced focused on the prospective use of DNA-guided personalized cancer treatment and use of tumor organoids—tiny living cell clusters—to study drug sensitivity. The Sta Op Tegen Kanker grants are supported by funds raised in connection with the Dutch versions of SU2C's televised fundraising events, broadcast in the Netherlands in cooperation with KWF .

Background: The SU2C-KWF Molecular Early Detection of Colorectal Cancer Dream Team Translational Cancer Research Project

Colorectal cancer is the third most common cancer (after lung and breast), and the fourth leading cause of death from cancer (after lung, liver, and stomach), in the world, and is second only to lung cancer as a cause of cancer death in developed countries, according to the World Health Organization's International Agency for Research on Cancer. In the United States, for example, it is the second leading cancer killer of men and women combined.

Patients can be effectively treated when the tumor is detected and removed early; however, the disease often develops without symptoms until it has reached an advanced stage. Screening is the most effective strategy for decreasing the rate at which colorectal cancer occurs and number of deaths it causes, with incidence and mortality rates declining in countries where screening has been introduced.

Stool or fecal-based tests are widely used in Western Europe and Asia and increasingly in the United States, with testing for blood (the fecal immunochemical test or FIT) as the standard approach. Although FIT has the potential to reduce colorectal cancer mortality by around 30 percent, improvements are needed urgently as approximately one-third of cancers, and more than two-thirds of precancerous lesions, are missed by this test. The sensitivity and accuracy of testing can be greatly improved using molecular stool tests, which detect cancer-specific biomarkers, such as DNA or proteins from cancer cells that are shed from the colon wall. The U.S. Food and Drug Administration recently approved the first stool-based colorectal screening test that detects blood and cancer-associated DNA changes and was better in clinical trial than FIT for detection of colorectal cancer.

The SU2C-KWF Dream Team's goal is to move highly sensitive molecular testing for colorectal cancer to the next level so it can become available to patients in everyday life. Their first aim is to improve molecular stool-based tests by using the best combination of cancer-associated DNA and/or protein biomarkers, so that these tests can go from the individual level to population screening. This new test will be compared directly against the current test in 10,000 individuals participating in the Dutch national population-screening program for colorectal cancer. Their second aim will be to develop a molecular blood test for circulating cancer-associated DNA in order to improve identification of early-stage colorectal cancer patients with a poor prognosis. Patients in the early stage generally do not receive chemotherapy after surgery because 80 percent survive the disease. The SU2C-KWF Dream Team hopes to develop a molecular blood test that identifies the other 20 percent of early-stage colorectal cancer patients whose survival may be improved by chemotherapy after surgery.

The project is expected to start early in 2015, with development of the new test in the first two years and the screening trial in the third year.

Grant guidelines stipulated that the leader of the project must be from a research institute located in the Netherlands, while co-leaders can be from research institutes in any country. Each project must include at least two research institutes located in the Netherlands and at least one research institute outside the Netherlands. At least 50 percent of the grant funds must be allocated to research conducted in the Netherlands.

In addition to the team leaders, a multidisciplinary group of experts who make up the Dream Team as principals are: Manon van Engeland, PhD, program leader in oncology at Maastricht University Medical Center; Ernst J. Kuipers, MD, PhD, professor of gastroenterology at Erasmus University Medical Center in Rotterdam; Evelien Dekker, MD, PhD, professor of gastrointestinal oncology at the Academic Medical Center of the University of Amsterdam; and Miriam Koopman, MD, PhD, medical oncologist at the University Medical Center Utrecht.

Laypersons serving as patient advocates on the Dream Team are Marcia K. Horn, president and chief executive officer of the International Cancer Advocacy Network (ICAN), and Jolien C.M. Pon, a colorectal cancer survivor and board member of the Foundation for Patients With Cancer in the Alimentary Canal (Stichting voor Patiënten met Kanker aan het Spijsverteringskanaal, SPKS) and president of the SPKS colorectal cancer patient group (SPKS Darmkanker Nederland).

Secondhand Smoke in Vehicles Exposes Nonsmokers to Toxic Compounds
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PHILADELPHIA — Secondhand smoke in the confined space of a motor vehicle resulted in exposure to several tobacco smoke toxins, and may ultimately increase risk for cancer and for respiratory and cardiovascular diseases in nonsmokers, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Secondhand smoke in vehicles resulted in substantial exposure to tobacco smoke toxins and increased risk for cancer," said Neal Benowitz, MD, chief of the Division of Clinical Pharmacology and Experimental Therapeutics at the University of California, San Francisco. "Some states have laws banning smoking in cars with children and this study supports the idea that there should be a total ban on smoking while a child is in the car."

Exposure to these toxins, or volatile organic compounds (VOCs), during even a brief period of time resulted in an intake level that far exceeded Environmental Protection Agency (EPA)-listed acceptable levels.

Benowitz and colleagues exposed 14 nonsmokers individually in the backseat of a car to one hour of secondhand smoke from a smoker in the driver's seat of the vehicle. The smoker smoked three cigarettes at 20-minute intervals. The car was stationary and the windows were kept open by 10 cm. The researchers measured the levels of nine VOCs before secondhand smoke exposure and zero to eight hours after exposure.

"We found significant increases in the levels of several VOCs, the most important ones being 1,3-butadiene, benzene, and acrylonitrile," Benowitz said. "1,3-butadiene and benzene are known human carcinogens and acrylonitrile is a probable human carcinogen."

After one hour of exposure, nonsmokers had a 2.1-fold increase in 1,3-butadiene, a 1.6-fold increase in benzene, and a 1.7-fold increase in acrylonitrile.

The researchers then used these measurements to estimate increased exposure for a nonsmoker exposed to secondhand smoke one hour a day, five days a week for 51 years. At this level of exposure, the researchers estimated that there would be an excess of 16 to 28 cancers per million adults.

"The acceptable risk from the EPA is one excess cancer per million people," Benowitz said. "Just looking at these three VOCs, and not including exposure to other VOCs, we can say that even moderate secondhand smoke exposure far exceeds an acceptable cancer risk."

This study was supported by the Flight Attendants Medical Research Institute, a U.S. Public Health Service grant, and the National Institutes of Health.

Benowitz served on smoking cessation advisory boards for Pfizer, has been an occasional consultant to McNeil and GlaxoSmithKline PLC, and has served as a paid expert witness in litigation against tobacco companies.

Oral Cancer-causing HPV May Spread Through Oral and Genital Routes
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PHILADELPHIA — Oral human papillomavirus (HPV) infections were higher among men who had female partners with an oral and/or genital HPV infection, suggesting that the transmission of HPV occurs via oral-oral and oral-genital routes, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"HPV is the most common sexually transmitted disease in the world and is a risk factor for several cancers, including cervical, vaginal, vulvar, oropharyngeal [throat/tonsil], anal, and penile cancers," said Eduardo L. Franco, DrPH, professor and director of the Division of Cancer Epidemiology and chairman of the Department of Oncology at McGill University Faculty of Medicine in Montreal, Canada.

"Understanding how HPV is transmitted is important because it will help us identify who is most at risk for HPV infection and how we can help them protect themselves and their partners," added Franco. "Our work provides additional evidence that HPV is sexually transmitted to the oral tract through oral-oral and oral-genital contact."

A research team led by Franco looked at HPV infections in 222 men and their female partners and found that among men in the study, the prevalence of oral HPV was 7.2 percent. These numbers were higher for men who were smokers (12.2 percent), those who were in nonmonogamous relationships (17.9 percent), and those who had a partner with oral HPV infection (28.6 percent) and/or genital HPV infection (11.5 percent).

Of the 222 men included in the analysis, 130 had a partner with a genital HPV infection.

The prevalence of HPV16, one of the most common cancer-causing HPV types, was 2.3 percent among all men who participated in the study and 6.1 percent among the 33 men who had partners with a genital HPV16 infection.

For every unit increase in the frequency of oral sex on the female partner (never/rarely, sometimes, or most times/always), men had a more than twofold increase in the prevalence of the specific HPV type present in the genitals of the female partner.

Participants were from the HPV Infection and Transmission Among Couples Through Heterosexual Activity study conducted at McGill University and led by Franco. Female students ages 18 to 24 and their male partners were recruited to the study between 2005 and 2011. Participants completed a questionnaire about their sexual history and provided oral and vaginal or penile/scrotal samples. The researchers analyzed the samples for the presence of 36 mucosal HPV types.

There were no HPV infections among the 52 men who never smoked cigarettes, were in a monogamous relationship, and had a partner without oral or genital HPV.

This study was funded by the Canadian Institutes for Health Research, the U.S. National Institutes of Health, and Merck. Franco declares no conflicts of interest but discloses that he occasionally serves as an adviser for companies involved with HPV diagnostics and HPV vaccination.

Even With Equal Health Care Access, Cancer Survival Rates Are Worse in American Indians and Alaskan Natives
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SAN ANTONIO — Five- and 10-year cancer survival rates were lower among American Indians and Alaskan Natives (AIANs) compared with non-Hispanic whites even when they had approximately equal access to health care, according to data presented at the American Association for Cancer Research (AACR) conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Nov. 9–12.

"Our preliminary analysis suggests that with presumed equal access to health care, five- and 10-year cancer survival among mostly urban-dwelling AIANs was lower than among non-Hispanic whites," said Marc Emerson, MPH, a cancer research training award fellow in the Division of Cancer Control and Population Sciences at the National Cancer Institute in Bethesda, Maryland. "Our study focused on AIANs who live largely in urban areas, a population often hidden to researchers.

"The AIAN population experiences some of the greatest disparities in health and health outcomes, yet this remains an understudied area of research," added Emerson. "Future research should focus on factors other than health care access that may be driving disparity in the cancer outcomes observed."

Emerson and colleagues found that the top four cancer diagnoses among AIANs and non-Hispanic whites were the same: prostate, breast, lung, and colorectal cancer. The fifth most common cancer type among AIANs was non-Hodgkin lymphoma, while it was melanoma for non-Hispanic whites.

The researchers also found that the five-year survival rates for AIANs and non-Hispanic whites were 52 percent and 58 percent, respectively, and the 10-year survival rates were 37 percent and 44 percent, respectively.

The most common comorbidities were the same for both races—chronic pulmonary disease, diabetes, and congestive heart disease—but the rates of these comorbidities were higher among AIANs compared with non-Hispanic whites. "In future analyses, we will examine the extent to which prevalence of comorbidities and other factors may account for the survival differences observed," Emerson said.

The researchers collected data from Kaiser Permanente Northern California electronic health records for 1,022 AIANs and 139,725 non-Hispanic whites diagnosed with primary invasive cancer between 1997 and 2012. They used sociodemographic and health data of the study participants, including age at diagnosis, race, cancer site, type of treatment, comorbidities, and treatment follow-up time, for their study.

This study was funded by the National Cancer Institute. Emerson declares no conflicts of interest.

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Family History of Breast or Ovarian Cancer is Linked to Triple-negative Breast Cancer in Women of Mexican Descent
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SAN ANTONIO — Breast cancer patients of Mexican descent who had a family history of breast or ovarian cancer were almost twice as likely to have triple-negative breast cancer than other subtypes of breast cancer, according to data presented at the American Association for Cancer Research (AACR) conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Nov. 9–12.

"Triple-negative breast cancer is one of the worst breast cancer subtypes in terms of outcomes," said Maria Elena Martinez, PhD, the Sam M. Walton endowed chair for cancer research and a professor in the Department of Family and Preventive Medicine at the University of California San Diego Moores Cancer Center in La Jolla. "So, our finding that family history is related to breast cancer subtype for Hispanic women of Mexican descent has tremendous implications for breast cancer treatment, screening, and prevention among this population. It not only affects decisions around treatment plans for patients, but extends to screening and prevention plans for family members.

"Before our study, we knew very little about the factors that affect Hispanic/Latina women's risk for breast cancer," Martinez continued. "The Ella Binational Breast Cancer Study was initiated to try and address this issue for Hispanic women of Mexican descent."

Martinez and colleagues found that among 1,150 women of Mexican descent with breast cancer who were enrolled in the Ella Binational Breast Cancer Study, 14.9 percent reported that they had a first-degree relative—parent, sibling, or child—who had received a breast or ovarian cancer diagnosis.

Information about breast tumor-subtype was available for 914 participants. The researchers found that women who reported having a first-degree relative with breast or ovarian cancer were almost twice as likely to have received a diagnosis of triple-negative breast cancer compared with another breast cancer subtype.

According to Martinez, other researchers have found that the prevalence of deleterious BRCA mutations among Hispanic/Latina women is higher than it is among women of European descent, by as much as 25 percent. She and her colleagues are, therefore, currently investigating whether BRCA mutations might explain the association they see between family history and triple-negative breast cancer.

This study was supported by funds from the National Institutes of Health, the Avon Foundation, and Susan G. Komen for the Cure. Martinez declares no conflicts of interest.

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HPV Vaccine Uptake Among Girls is Lowest in States With Highest Rates of Cervical Cancer
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SAN ANTONIO — The proportion of adolescent girls receiving human papillomavirus (HPV) vaccines was much lower in states with higher rates of cervical cancer incidence and mortality, according to data presented at the American Association for Cancer Research (AACR) conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Nov. 9–12.

HPV vaccines can prevent individuals from developing several types of cancer, including cervical, anal, vaginal, and vulvar cancers.

"Cervical cancer incidence and mortality rates vary widely by state," said Jennifer L. Moss, MSPH, a doctoral student in the Department of Health Behavior at the University of North Carolina Gillings School of Global Public Health in Chapel Hill. "Our data show that adolescent girls remain vulnerable to disease in areas where women already have a higher risk of developing and dying from cervical cancer. If more adolescents, both girls and boys, in these states received an HPV vaccine, their risk of HPV-related cancers would drop dramatically.

"Teens don't visit their health care providers as often as younger children, so increasing the frequency and efficiency of preventive visits is really important for HPV vaccination and cancer prevention," continued Moss. "We know that a health care provider's recommendation is the single biggest influence on whether an adolescent receives an HPV vaccine. So, we hope that the findings of our study impress upon clinicians, especially those practicing in states with higher cancer rates, that cancer prevention means recommending HPV vaccination to adolescent patients at every visit."

Moss and colleagues collected data on HPV vaccination rates in different states from the National Immunization Survey–Teen and on cancer rates in different states from the United States Cancer Statistics database.

They found that as cervical cancer incidence rates increased, HPV vaccine initiation rates among girls decreased. "For example, in a state like Massachusetts, about 6 per 100,000 women develop cervical cancer each year and 69 percent of teen girls have initiated HPV vaccination," said Moss. "However, in states with higher rates of cervical cancer incidence, such as Arkansas, where the rate is 10 per 100,000 women, vaccination is much lower—41 percent of teen girls."

HPV vaccine initiation was also lower among girls living in states with higher cervical cancer mortality rates, higher proportions of non-Hispanic black residents, and lower proportions of high-income residents. Completion of the three-dose course of HPV vaccine was higher in states with greater levels of adolescent contact with the healthcare system.

According to the researchers, the current patterns of HPV vaccination may not be adequate to reverse the current geographic disparities in HPV-related cancer incidence and mortality. They suggest that strengthening adolescent preventive health care use may be particularly important to increase completion of the HPV vaccine course.

Moss' co-authors on the study are Paul L. Reiter, PhD, assistant professor at The Ohio State University in Columbus, and Noel T. Brewer, PhD, associate professor at the University of North Carolina.

This study was supported by funds from the National Institutes of Health. Moss declares no conflicts of interest.

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Culturally Sensitive, Computer-based Videos Increase Clinical Trial Awareness Among Latina Breast Cancer Patients
http://www.aacr.org/Newsroom/Lists/News Releases/AllItems.aspx

SAN ANTONIO — Latina breast cancer patients provided with information about clinical trials in multiple ways, including a culturally sensitive, computer-based video on breast cancer clinical trials, had much greater awareness of clinical trials compared with patients who received usual-care information, according to data presented at the American Association for Cancer Research (AACR) conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Nov. 9–12.

After receiving the additional information, the proportion of Latina breast cancer patients taking steps toward participating in a clinical trial increased from 38 percent to 75 percent.

"Latinos represent 17 percent of the U.S. population but only 5.6 percent of participants in National Cancer Institute treatment clinical trials," said Patricia Chalela, DrPH, assistant professor of epidemiology and biostatistics at the Institute for Health Promotion Research (IHPR) at The University of Texas Health Science Center at San Antonio. "Underrepresentation of minorities in clinical trials results in disparities of cancer outcomes and limits generalizability of the findings because researchers cannot study how minority patients respond to new treatments.

"Our results showed that intervention participants had significantly higher awareness of clinical trials than control participants," continued Chalela, who is part of the study team led by Amelie G. Ramirez, DrPH, director of the IHPR. "We hope that computer-based videos specifically tailored for Latinos will provide an effective strategy to increase Latina breast cancer patients' knowledge, understanding, and participation in clinical trials, although this needs confirming in larger studies."

The study is in its last year of recruitment. To date, Chalela, Ramirez, and colleagues have enrolled 71 Latina breast cancer patients eligible to participate in a breast cancer clinical trial at the Cancer Therapy and Research Center at the UT Health Science Center San Antonio. Participants are randomly assigned to usual-care clinical trial information or additional information, which is provided through viewing of a culturally sensitive, computer-based video about breast cancer clinical trials, reading a tailored booklet on the topic, and receiving assistance from a patient navigator.

When compared with patients assigned to usual-care clinical trial information, patients assigned to additional information had significantly higher awareness of clinical trials, in particular, the purpose of clinical trials, the requirements for enrollment, the benefits and risks of clinical trials, and the potential of clinical trials as an appropriate treatment for a serious disease.

"These results are encouraging," Chalela said. "We would like to assess the intervention at a larger scale and make the intervention available not only to all breast cancer patients, but expand it to all cancer patients in general."

This study was supported by funds from Susan G. Komen, the Cancer Therapy and Research Center at the UT Health Science Center San Antonio, and Redes En Acción, a National Cancer Institute–funded Latino cancer research network based at the Institute for Health Promotion Research at the UT Health Science Center San Antonio. Chalela declares no conflicts of interest.

#AACRDisp14


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ONE in five of Scots will retire abroad. That seems an astonishing claim. The phenomenon already has a term in estate agency circles - "the silver flight". If the claim is correct, it has vast implications for Scottish business. Many of the effects may be indiscernible now.
If one in five couples, retiring at 60 or 65, flees to sunshine locations, it seems obvious the Scottish property market will have to evolve to accommodate the phenomenon. Yet will people jetting off to Florida or the Canaries sell their homes in Dunblane or Dundee? It seems unlikely they would just leave their primary asset empty. They will either sell up or rent out their homes.
The research was conducted by the Institute for Public Policy Research. They also found what are already the favoured locations for this retiring migration. I was surprised to learn Australia is the most popular destination followed by Canada then the US. America seems to mean mostly Florida, already a retirement state for so many New Englanders.
Spain is the top location for Scots retiring to Europe, followed by Italy and France. The statistics are exhaustive in detail - three Scots have retired to Libya, two to Afghanistan and one to Kazakhstan. Is it possible the figures include immigrants in reality settling back in their homelands ? It does seem that many Pakistanis and West Indians aspire to return to their places or origin, enriched by their time in Scotland and probably carrying UK pension rights which will give them princely incomes compared to those who never worked in Britain.
The phenomenon of emigration from Scotland is nothing new but the texture is quite different. This is no Highland Clearances. This is not destitute Scots migrating to the New World to find employment impossible in Lanarkshire or Fife. Past migrant flows were essentially young people seeking to make their fortunes. The force identified by these researches is affluent retired couples who simply want to escape the raw weather of Scotland and enjoy guaranteed sunshine.
I think it possible technology is at work here too. The internet makes home contact almost instant, constant and intimate. Letters from Tasmania to Tayside can take three weeks. An e-mail arrives in a nanosecond. Satellite TV also keeps us in touch. "Scots Greys", as they are coming to be termed, can tune into BBC Radio Scotland or Reporting Scotland in Fort Lauderdale as easily as Fort William. Indeed there may be a real pang of pleasure at seeing the frost reports and news of traffic snarl-ups while watering your bougainvilleas.
One serious misgiving about living abroad in the past was the loss of your morning copy of The Scotsman but you can read it on line in Tierra del Feugo or Thailand now. Distance is dead.
Come to think of it, I am forgetting my wife and I are part of this new force. We have a home in West Virginia which is a refuge that gives us great pleasure. I can't quite envisage abandoning the UK, but, like most families, we have now seen much of the world and lost the insularity of past generations.
If one in five of those currently in employment flees, it invites questions about those left behind. It seems indelicate to mention it, but Scotland has a sort of under-class on the bigger council estates, largely locked out of employment and often attending schools which impart little education. These people will not be part of any "silver flight". They will stay in Scotland with little prospect of sunshine even though a mere state retirement pension would render them rich in many parts of the world.
One misgiving that may have deterred this migration is the trust and affection in which the National Health Service was regarded. My guess is that, the more we travel, the more we are aware that the NHS is now very far from being "the envy of the world". We observe other nations' medical provisions

subset: commoncrawl


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Australia may have already clinched the series against South Africa but they have the incentive of top spot on the world one-day rankings in Sunday's fifth ODI in Sydney. The Proteas, meanwhile, need to salvage some pride. Follow it here.
It's the second ODI in Chittagong, where the Tigers are looking to extend their series lead and Zimbabwe desperately need to get their form to World Cup standard.
Pakistan received some good news on their injured key players Saturday with opener Ahmed Shehzad set to return for the limited over series against New Zealand.
13 Nov 2014 10:00
India v Sri Lanka
India v Sri Lanka
India won the toss and elected to bat
22 - 26 Oct 2014 08:00
Pakistan v Australia
Pakistan v Australia
Day 2 - Session 1 - Pakistan won the toss and elected to bat
22 Oct 2014 15:00
Momentum One Day Cup
Cape Cobras v Knights
Cape Cobras won by 73 runs
19 Oct 2014 10:00
Momentum One Day Cup
Cape Cobras v Lions
Cape Cobras won by 53 runs
19 Oct 2014 10:00
Momentum One Day Cup
Dolphins v Warriors
Warriors won by 4 wickets (with 3 balls remaining)
Peter Miller read Kevin Pietersen's telling autobiography, despite a plethora of excerpts laden across the internet. It is worth the money, but there isn't enough talk about cricket...


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The fashion spotlight has been on New York this week as the Fashion Week season kicked off and, while all eyes were on the usual suspects (Olivia Palermo, Alexa Chung, Kirsten Dunst) to pull out all the stops for the bi-annual fash-off (its not all about the catwalk looks don't you know?!) one girl in particular grabbed our attention, Poppy Delevigne. The British model and socialite bought some inspiring edge to the front row by mixing key designer pieces like her trophy jacket and printed Brian Reyes skirt with an off-beat studded waistcoat by All Saints and unsuspecting Converse high-tops. Even her softer looks (see the floral DKNY S/S'10 hot-off-the-runway dress) looked effortless with minimal jewellery and her easy flowing locks. What a hot rep for fashionista Brits abroad. Poppy you rule!
- Catherine Nieto


text: Mechanical & Manufacturing Eng (Scholarly Publications) Mechanical & Manufacturing Eng (Scholarly Publications) http://hdl.handle.net/2262/208 2014-11-29T06:07:46Z 2014-11-29T06:07:46Z Observations of Surface Acoustic Wave Strain and Resistive Strain Measurements on Broaching Tools for Process Monitoring ALDWELL, BARRY GERAGHTY, THOMAS DERMOT http://hdl.handle.net/2262/72139 2014-11-25T03:03:38Z 2014-01-01T00:00:00Z Observations of Surface Acoustic Wave Strain and Resistive Strain Measurements on Broaching Tools for Process Monitoring ALDWELL, BARRY; GERAGHTY, THOMAS DERMOT David Dornfeld and Moneer Helu The monitoring of high end material removal processes continues to develop to greater levels of technical sophistication which in turn enable greater levels of insight into the process phenomena occurring at the tool-chip interface. The broaching process is a traditional machining process which is used extensively in the manufacture of some of the most expensive components of the aero engine. As a relatively slow cutting process with low degrees of freedom, broaching could be a target for strain based monitoring. It is well known that strain gauges provide a rich source of data when installed close to the cutting process. This research provides insight into the resistive strain gauge measurements during broaching. The paper also specifically focuses on the use of surface acoustic wave based strain measurement and provides some initial observations on the strain data available during tooth loading and cutting scenarios in broaching PUBLISHED 2014-01-01T00:00:00Z The energy saving opportunity in targeting non-value add manufacturing activities a structured approach O'DONNELL, GARRET EDWARD http://hdl.handle.net/2262/71494 2014-10-15T02:03:03Z 2014-01-01T00:00:00Z The energy saving opportunity in targeting non-value add manufacturing activities a structured approach O'DONNELL, GARRET EDWARD With an ongoing increase in industrial energy demand anticipated in Europe, energy efficiency continues to be an important focus within industrial environments. This paper documents an approach to support the study and analysis of energy optimisation within complex manufacturing process chains. It focuses on generating an energy characteristic for complex discrete part manufacturing equipment and identifying optimisation opportunities based on targeting non value added process states. A structured problem solving approach is used to identify and evaluate risk factors associated with the implementation of improvements with qualitative workforce input supporting the risk assessment. It also develops an assessment of an organisations capability to manage an energy improvement in order to minimise risk to core Overall Equipment Effectiveness metrics thereby ensuring opportunities are feasible and pragmatic. This supports a deeper understanding of energy use and potential operational impacts due to energy based change. This demonstrates the need to consider the implications of energy change to an organisation in terms of operational metrics. The approach has been applied successfully across a range of manufacturing industries including multinational environments such as information and communication technology, pharmaceutical and medical device as well as Irish small and medium enterprises. The case study presented delivered a 51% reduction in energy consumption for targeted manufacturing states used by discrete part manufacturing equipment. PUBLISHED 2014-01-01T00:00:00Z Implant device MURPHY, BRUCE http://hdl.handle.net/2262/71492 2014-10-15T02:03:07Z Implant device MURPHY, BRUCE SUBMITTED Microstructure and Micro Hardness of Friction Stir Welded AA2024-T3 Joints MC FADDEN, SHAUN http://hdl.handle.net/2262/71413 2014-10-02T02:02:30Z 2014-01-01T00:00:00Z Microstructure and Micro Hardness of Friction Stir Welded AA2024-T3 Joints MC FADDEN, SHAUN G. Kelly Macrostructure, microstructure and micro hardness of friction stir welded AA2024 - T3 joints was studied. The influence of tool pin profile on the microstructure and hardness of these joints was examined. Square, triflute and tapered cylinder pins were used in this study. Vickers micro hardness tests and grain size measurements were taken from the transverse plane of welded samples. Distinct zones in the macrostructure were evident. The zones were identified by transitions in the microstructure and hardness of weld samples. 2014-01-01T00:00:00Z


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Lady Gaga Fans at US Airways Center
By Melissa Fossum
The Evolution of the Metal Stage Show and the End of...
By Lauren Wise
By New Times
The Story of Kalliope, Phoenix's Extraordinary Party Car
By Amanda Savage
By Jason P. Woodbury
How a Single Tweet Launched A Cloud for Climbing
By Troy Farah
By New Times
"I always said I hated the Black Crowes," says Mike, sipping a Diet Coke. "Then one day someone put on a Black Crowes album and I was like, 'Who is this?' There were four or five songs I liked — I mean, really liked." I agree with Mike, staring at his vinyl copy of Amorica, complete with original, uncensored artwork. If you can get past the cover of Otis Redding's "Hard to Handle" — all those memories of a time when the Spin Doctors shared bandwidth with Nirvana — and set aside the shameful white-boy blues tag and the fabricated neo-hippie bullshit, the Crowes actually wrote some good tunes. I think of the Crowes listening to Eric Lindell's "Bodega," from his new record, Between Motion and Rest. It's got the same easygoing sensibility and charm. The rest of the disc from the New Orleans-via-San Mateo, California, singer/songwriter splits the difference between the blue-eyed soul of "It's Hard to Believe," the bluesy "Lucky Lucky," and the NOLA groove of "Matrimony." It never sounds forced, suggesting Lindell may have a few LPs by Van Morrison, Dr. John, Ben Harper, and, yeah, the Crowes laying around his place, though Lindell doesn't have any iconic album covers to his name, just yet.


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Hotel Information
Kellogg Conference Hotel at Gallaudet University
800 Florida Avenue, NE
Washington, DC 20002-3695
(202) 651-6000
Located just minutes from Capitol Hill, the Kellogg Conference Center is located on the beautiful gated grounds of Gallaudet University. The Washington, DC campus provides guests with comfortable rooms, platinum-level service, and expertly prepared culinary treats.
Amenities at the hotel include the Outtakes Internet bar, a two-story atrium lobby, ample parking, an enclosed sidewalk café, a fitness center, and access to downtown Washington, DC museums and attractions, such as the Verizon Center and Chinatown.
The NCLR group rate is $169/night, available through Monday, February 10, 2014, 5:00 p.m. EST. You must register to get the discounted hotel code.
Reservation requests received after Monday, February 10, 2014, 5:00 p.m. EST will be accepted on a space available and a rate available basis.
Standard Rooms
Coffee maker with complimentary coffee, iron and ironing boards, TTY (teletypewriter), two phones, Sorenson VP–100 videophone, 27" TV, hair dryer, marble-top desk with ergonomically correct chair, and FREE high-speed Internet access.


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The room choice is plentiful at Armani Hotel Dubai. If only the best is good enough, with 5 stars you'll have all you need. Accessible within a short radius from this location, Burj Dubai and Dubai Fountain can be reached on foot. This accommodation is well located for convenient access to Emaar Square bussiness centre.
Visitors can make use of a bar/lounge and a coffee shop/café in Armani Hotel Dubai. An outdoor swimming pool proves a pleasant addition to the available swimming facilities. The hotel's health and wellness facilities include a sauna, a spa/wellness center and a steam room. Amongst the services you may find beneficial here are a dry cleaning/laundry service, an express check-in/out service and a wedding service. One segment of the shopping opportunities can be found on the premises: in a gift shop. Meetings are possible in one of the 11 meeting rooms. The hotel offers entertainment such as a night club. A paid airport shuttle bus, a paid area shuttle bus and a paid shopping centre shuttle bus are also offered here. For guests that come by car, there is a free valet parking service.
Armani Hotel Dubai is fitted with air conditioning. This accommodation has pleasant rooms that include a housekeeping service amongst other facilities. Internet options are offered via wireless high-speed Internet access (complimentary). Modern touches such as a DVD/VCR player is available in the rooms here. Scrub up to your best with a bidet, a designer toiletries set and a separate bathtub and shower.
Show reviews
|From 15:00 Check-out: Until 12:00
|Wireless high-speed Internet access (complimentary), Free wired Internet
|Free Valet Parking
|Airport shuttle:
|Airport Transportation (surcharge), Paid Area Shuttle Service, Paid Shopping Centre Shuttle
|General facilities:
|Extra common areas:
|Business facilities:
|Wellness facilities:
|Swimming Facilities:
|Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. We are not responsible for any inaccuracies in the photos.
Please provide this reference number to our customer service center representative on request, so we can help you better


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229 North Natchez Trace Road
Mathiston, MS 39752
ph: 800-898-0438
fax: 662-263-8230
alt: 662-263-8202
Proudly supporting the East Webster Wolverines
12700 Sturgis Maben Rd., Maben
Immaculate and move in ready! Offers 3 spacious bedrooms with huge walk in closets. 2 very large and open bathrooms, open kitchen and dining as well. This well maintained home is situated on 1.0 acre with garage, outside storage building, and in ground storm shelter. Concrete drive and large covered front porch. Less than 15 minutes to Starkville! Offered at only $134,900.
1953 Vickers Double Springs Church Rd, Mantee
Beautiful and spacious 5 bedroom/4.5 bath home. This incredible listing is well maintained and ideal for entertaining with grand foyer, large formal dining room, brick patio, 24'x 24' tractor shed,bonus room and more! This property has been very well maintained and is situated on 4.5 acres in East Webster Schools/Sumner money.
Beautifully renovated 3 bedroom/1 bath home with large living room, incredible kitchen, and plenty of storage. This property will qualify for no money down financing. Call today for details. Offered at $89,900. Imagine payments less than rent...
66 Love Hill Road, Maben
Charming 3 bedroom/2 bath home with fireplace and gas logs insert is warm and welcoming. This home has been very well maintained and is in move in condition. Situated on .89 acre and also offers guest house, ouside storage/shop area and wooded views. This property is being offered at an incredible $87,500.
Personal Care Facility!
Located on historic Second Avenue in Maben, this former hospital was successfully used as a Personal Care Home. The property offers almost 8,000. square feet with common areas, public facilities, kitchen and dining areas, and 13 private rooms. Each room featuring an emergency call system as well as individually controlled heating and cooling. This property is being sold as it with all furniture and fixtures remaining. The listing offers incredible income potential! Ideal for a personal care home, children's home, hospice facility, or subdivided as a professional complex. Offered at only $89,900. Call today for additional information and to schedule your tour.
This full service automotive repair business is being offered in total. With over 4000 sq.ft. under roof. 3 functional bays, each with its own lift. In addition to this, there is a 1600 sq.ft. area ideal for working on large equipment repairs. This successful business has been in operation since 1993. It is an established business being sold to include all inventory stocked on site. Also offers 112 sq.ft. office and restroom area for patrons. Located directly on Highway 12 with excellent exposure as well as convenience. This property is being offered in the $250's.
Since this is a working business, we ask that you schedule an appointment to view.
To access additional listings in the area, click on the above link. Tenhet Real Estate can show you any listings. We appreciate you allowing us the opportunity of working with you. We will negotiate on your behalf to get you the best deal available. We are here for you, its what we do!
135 Union Street, Mathiston
Charming 3 bedroom/1 bath home situated on 130' x 200' shaded lot. Partially fenced. Offers central heat/air, hardwood floors, partial basement, and more! This property qualified for Fannie Mae HomePath Mortgage Financing & HomePath Renovation Mortgage. Open to owner occupants only through Aug. 5th. Only $59,900.
1857 Barnett Road, Maben
Bring on the horses, fourwheelers, and family fun. Tucked away on 10 beautiful acres, this property is absolutely incredible! Offers split rail fencing, pond, 3 stall horse barn with tack room. The home is move in ready with 3 bedrooms/2 baths plus bonus room. This property is convenient to EW High School, and Sumner Grant available. Offered at only $189,900.
Former RedCap building has been drastically reduced and is being offered at an incredible new price of only $599,000.
Built in 1990, this property has 72,600 sq.ft. and is situated on 18 acres directly on Highway 82, this property offers incredible potential and could easily have acreage developed in front of the building. The possibilities are endless. Owner will consider possible lease. Spec sheet attached. Click the photo to download.
40 ACRES vacant land. Webster County, (Eupora) Ideal for recreational at only $1199 per acre. Call for details.
229 North Natchez Trace Road
Mathiston, MS 39752
ph: 800-898-0438
fax: 662-263-8230
alt: 662-263-8202


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March 26, 2014 - Industry News
MATS, LOUISVILLE, KY -- A panel discussion of innovative fleet leaders Wednesday illustrated why one size does not fit all is not an approach that works well in the trucking industry.
Tags: Natural Gas, Vehicle Spec'ing, Engines, Mid-America Trucking Show, HDT Truck Fleet Innovators, Frito-Lay, PepsiCo, Meijer, NFI
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from Citgo will answer your questions Ask a question
Video:60 Minutes Report on Crumbling Infrastructure
Detroit Assurance: Collision Mitigation, Assisted Braking, Better MPG
Unsung Documentary Series: Baker Trucking
Ultimate Test Drive Video: SuperTruck A Walk Around
Kenworth Introduces World's Best Trucks 2015 Calendar
East Manufacturing Releases Scale Model Tractor-Dump Trailer
Minimizer Offers Decorated Bracket Kits
Kenworth Cabover Options Expand Applications


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Are Worries about the Health of Democracy Today Overblown?
Joshua Kurlantzick joins the Economist's debate: Are worries about the health of democracy today overblown?
See more in Global; Peace, Conflict, and Human Rights
Joshua Kurlantzick joins the Economist's debate: Are worries about the health of democracy today overblown?
See more in Global; Peace, Conflict, and Human Rights
"In the 667-page world report, its 24th annual review of human rights practices around the world, Human Rights Watch summarizes major issues in more than 90 countries."
See more in Global; Human Rights
The crisis in the Central African Republic has reignited, threatening regional long-term peace and stability unless a neutral transitional administration is formed, says CFR's John Campbell.
See more in Central African Republic; Peace, Conflict, and Human Rights
In keeping with the core mission of the Center for Preventive Action, this meeting evaluates the most worrisome sources of instability and conflict in 2014.
See more in Global; Peace, Conflict, and Human Rights
In keeping with the core mission of the Center for Preventive Action, this meeting evaluates the most worrisome sources of instability and conflict in 2014.
See more in Global; Peace, Conflict, and Human Rights
"It will be nearly impossible for observers to do a credible job under the present conditions in Egypt. And even if the referendum goes smoothly, it is not at all clear that the vote will make a meaningful contribution to getting Egypt back onto a democratic path. Observers and foreign governments, including the United States, would do well to make sure that their engagement and statements keep the focus on the big picture of Egypt's worrisome trajectory."
See more in Egypt; Elections; Democratization
Mark Lagon describes how over three-quarters of trafficking victims in the global economy are exploited for their labor, and explains how much of this modern-day slavery is linked to the fishing industry.
See more in Global; Human Trafficking
Child marriage remains widespread in developing countries, disproportionately affecting girls and endangering their lives and livelihoods. Rooted in cultural tradition and poverty, the practice not only violates human rights laws but also threatens stability and economic development.
See more in Global; Peace, Conflict, and Human Rights; Children
See more in Global; Human Rights
Elliott Abrams writes that Syria will cast a long pall over the Obama record.
See more in Syria; United States; Peace, Conflict, and Human Rights
El Salvador's February 2 election may bring to power former FMLN guerrillas closely tied to the FARC in Colombia and to the regime in Venezuela, writes Elliott Abrams.
See more in Latin America and the Caribbean; Peace, Conflict, and Human Rights
The Global Conflict Tracker is an interactive guide to U.S. conflict prevention priorities in 2014 and is based on the most recent Preventive Priorities Survey (PPS).
See more in Global; Peace, Conflict, and Human Rights
As the crisis in Syria continues in the new year, Gayle Lemmon writes about the tragedies facing one group left out of diplomatic conversations, yet is vital to the country's future: Syria's children.
See more in Syria; Human Rights
The State Department's Bureau of Democracy, Human Rights, and Labor produced this report. The preface states, "Pursuant to the Advancing Democratic Values Act of 2007, the Department of State has prepared this report on U.S. efforts to promote democracy and human rights in nondemocratic countries and countries undergoing democratic transitions worldwide."
See more in United States; Democratization
Despite the administration's much-publicized Asia "pivot," the spreading impact of the Syria conflict and negotiations to limit Iran's nuclear program will continue to top the foreign policy docket, says CFR's James M. Lindsay.
See more in Global; Defense and Security; Peace, Conflict, and Human Rights
The Kremlin source told Reuters that for Putin, Khodorkovsky would have been much more of a headache if he served his sentence and was released as scheduled. If he were to stay in Russia, he would attract more attention for longer, which could empower him, the source said, adding that this way, Putin had closed his way back to Russia.
See more in Russian Federation; Human Rights
Former oil tycoon Mikhail Khodorkovsky, just pardoned after ten years in prison, is unlikely to challenge Putin at the ballot box, but don't rule out a role for him in Russia's political opposition, says expert Dimitri Simes.
See more in Russia and Central Asia; Peace, Conflict, and Human Rights
To help U.S. officials and policymakers focus on the most important conflict prevention demands, CFR's Center for Preventive Action produced its sixth annual Preventive Priorities Survey (PPS), which evaluates ongoing and potential conflicts based on their likelihood of occurring in the coming year and their impact on U.S. interests. Micah Zenko discusses the process, findings, and utility of the PPS.
See more in Global; Conflict Assessment
"The fighting has already claimed thousands, if not tens of thousands, of civilian lives. Hundreds of thousands of South Sudanese have fled into the bush or returned to home villages, according to the UN. The official death toll of 500, which corresponds with the number of dead in a single Juba hospital six days ago, is being dismissed by experts."
See more in South Sudan; Peace, Conflict, and Human Rights
Unrest in the Middle East, brinksmanship in the East China Sea, and instability in Afghanistan and Pakistan top foreign policy experts' concerns for 2014, says CFR's Paul Stares.
See more in Global; Conflict Prevention
The authors argue that it is essential to begin working now to expand and establish rules and norms governing armed drones, thereby creating standards of behavior that other countries will be more likely to follow.
The author examines Pakistan's complex role in U.S. foreign policy and advocates for a two-pronged approach that works to quarantine threats while integrating Pakistan into the broader U.S. agenda in Asia.
The authors assess the political, security, and economic challenges facing U.S. policymakers in Afghanistan and evaluate a range of policy options.
Maximalist finds lessons in the past that anticipate and clarify our chaotic present, revealing the history of U.S. foreign policy in an unexpected new light. More
This clear and authoritative book presents a sweeping account of China's global resource quest and the unrivaled expansion of its economy. More
The story of the tragic and often tormented relationship between the United States and Pakistan, and a call to prepare for the worst, aim for the best, and avoid past mistakes. More
Learn more about CFR�s mission and its work over the past year in the 2014 Annual Report. The Annual Report spotlights new initiatives, high-profile events, and authoritative scholarship from CFR experts, and includes a message from CFR President Richard N. Haass.
Read and download »


text:
Home » News » Politics » Town Meetings
Six percent turnout at Gilmanton's first SB-2 session
Residents amended several articles in the proposed $3.3 million budget during the five-hour meeting, said Debra A. Cornett, the town clerk and tax collector.

It took three times to amend Article 27, which as proposed asked voters for $44,000 to be deposited in the town's Capital Reserve Ambulance Replacement Fund.

One amendment was proposed that would have reduced that amount to $5,000 but that failed. A second amendment that failed would have eliminated the deposit entirely, Cornett said.

After much discussion, a third amendment was passed that changes the amount to be deposited in the ambulance fund to $22,000.

Also amended was Article 28, which proposed $87,000 to be deposited in the Capital Reserve Fire Engine Fund. Residents chose to change the amount to the budget committee's recommended $85,000. The selectmen had not recommended this article.

Residents also sided with the budget committee on Article 32, which would have asked voters for $64,040 to be deposited in the Capital Reserve Highway Equipment Fund. The selectmen did not recommend this article, but the budget committee recommended the amount of $30,000, which was the voter's preference as well.

Voting will take place on March 12 at Gilmanton Academy from 7 a.m. to 7 p.m.

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Renegade & PARANoIR Present: WWE 2006
View Single Post
Made Out Of Nothing
Join Date: Jan 2006
Posts: 11,589
Re: WWE 2006 by Renegade
Well, I never had the chance to review the two weekly shows like I said, so finally I'll be able to return the review I owe you by reading and reviewing this upcoming, major PPV! Yipee! Until then, though, here are my predictions:
WWE Championship; Last Man Standing Match
Triple H vs
Shawn Michaels
- Michaels > God, 'nuff said.
Mixed Tag Match
The Rock & Trish Stratus vs
Edge & Lita
- Gotta go with the heels in this one, as it's more of a feud-advancer match than a real match, and the heels need more of a win in this situation, so Edge & Lita take my pick.
Rob Van Dam
vs Christian w/Tomko vs Shelton Benjamin - Now, this is a tough choice, as really anyone could go through, but I'm gonna go with RVD as he really hasn't had a main event spot yet, while Christian has kinda had his shot and Benjamin isn't ready.
Intercontinental Championship Match
AJ Styles
vs Charlie Haas (c) - Been liking this feud so far, and Haas has retained against a lot of odds (I think he retained at KOTM, but I could be mistaken...hopefully I'm not), so I think it's his time to drop the belt and take the clean loss.
Kane vs
John Cena
- Cena, like Brown, has a better chance of succeeding in this thread than Kane, so gotta go with'em.
World Tag Team Championships
Dudley Boyz
vs Cade & Jindrak (c) - Dudleys > Jesus & Moses, so, they shall win. 'Nuff said.
Hardcore Championship; Clockwork House of Fun Match
RAW vs SmackDown! Challenge
Guest Referee: Mick Foley
Rhyno (c)
vs Hardcore Holly - Rhyno is definitely winning, as I just don't see Holly getting any sort of real push for some reason. I like Holly and wish he'd win, but I gotta go with Rhyno.
Carlito w/Torrie vs
Monty Brown w/The Coach
- Brown has a better chance of going far in this thread, as Carlito hasn't done much of anything while Brown dominated the KOTM match earlier in the year at SummerSlam and since then hasn't slowed down.
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If I had multiple personalities I'd play with myself all day. I wouldn't even leave the house. I'd give my girlfriend a penny every time she correctly guessed which one of me was fondling her.
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November 29, 2014
January 3, 2013
Another state lawmaker is opposing the reappointment of UVa Rector Helen Dragas, following the failed attempted ousting of President Teresa Sullivan.
According to a new report, Senator Barbara Favola declared her opposition on Wednesday.
The Arlington County Democrat says, Dragas didn't demonstrate values needed to lead UVa to new heights.
Several other lawmakers have said they would oppose Dragas' reappointment.
The General Assembly will consider the reappointment when it convenes this month.
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Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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Student Suspended After Fly Over At High School Football Game
Posted: 11/06/2007 - A 17-year-old high school student accused of flying a single-engine plane over a football game has been suspended.
Posted: 11/06/2007 - A 17-year-old high school student accused of flying a single-engine plane over a football game has been suspended.
Posted: 11/06/2007 - Wake County's sheriff is about to get some help making sure his jail's inmates are legal residents of the United States.
Posted: 11/06/2007 - Larry Kissell vowed a rematch against U.S. Rep. Robin Hayes almost a year ago. He made it official Monday, kicking off his campaign for Congress with a day of campaigning in the 8th District.
Posted: 11/06/2007 - The SBI has been called in to investigate the death of a Hendersonville man who had an apparent heart attack after deputies subdued him with a stun gun at the jail.
Posted: 11/06/2007 - In a symbolic move, Duke University is waiving its decades-old rights to prohibit blacks from purchasing property in Duke Forest.
Posted: 11/06/2007 - We're less than a week into November, and there's been a second shooting so far this month in Greenville.
Updated: 11/05/2007 - Some voting officials don't expect a big voter turnout Tuesday.
Updated: 11/05/2007 - Companies that rely on delivery drivers adjust to rising prices.
Posted: 11/05/2007 - Officer faces DWI and speeding charges.
Updated: 11/05/2007 - Beaufort County School officials say the eight students and bus driver taken to the hospital following a Monday accident have been released.
Updated: 11/05/2007 - Methamphetamine is a serious concern that grew dramatically in our state back in 2004 and 2005. The number of meth labs exploded during those years, putting more and more people at risk.
Updated: 11/05/2007 - Deputies say 22 year old Alejandro Garcia grabbed the 12 year old girl and took her to his bedroom. As the victim was yelling, her two friends ran for help.
Posted: 11/05/2007 - The law allows teenagers to drive while talking to their parents or law enforcement, but officers say its difficult if not impossible to estimate the age of young drivers.
Updated: 11/05/2007 - A 17 month investigation by the State Bureau of Investigation has resulted in the indictment and arrest of Lisa Brickhouse of Kill Devil Hills.
Posted: 11/05/2007 - The school system says a nearby traffic accident cut off power to Southside High School, and when emergency power came on part of the school filled up with smoke.
Posted: 11/05/2007 - As most of the country moved their clocks an hour back last weekend, some Alltel customers in North Carolina and three other states saw their cellular phone clocks jump forward instead.
Updated: 11/05/2007 - If you're going to have a heart attack, North Carolina is considered the place where you might survive it.
Posted: 11/05/2007 - Some gas stations in Greenville Monday are posting a price that is just a fraction of a penny away from three dollars a gallon.
Posted: 11/05/2007 - The man accused of setting fire to two churches in Greenville has a scheduled court appearance on Monday.
Updated: 11/05/2007 - The Cherokee Tribal Police Department has found Derrick NMI Taylor.
Updated: 11/04/2007 - It's a mainstay on Main Street in the City of Washington and Saturday night the curtains opened to the Turnage Theater Stage.
Updated: 11/04/2007 - It's a device that can save lives, especially for a person suffering from a heart attack and time is of the essence.
Updated: 11/04/2007 - New Bern Police have identified the man found dead Saturday morning on First Avenue. They say 56 year old Robert Carol Pugh was shot down and left in the street.
Updated: 11/04/2007 - Greenville Police Officers are still searching for one more person who may have information into a fatal shooting on Friday.
Posted: 11/04/2007 - As most of the country moved their clocks an hour back today, some Alltel customers in North Carolina and three other states saw their cellular phone clocks jump forward instead.


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Tag: car service
Car-service app Uber heads for NYC market
Uber is a service that connects an iOS app to a car booking network, so essentially you can use your iPhone to signal that you need a car, and then one shows up, complete with a driver ready to take you to your destination. We've seen taxis do this with Taxi Magic, but Uber is designed to not o...
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- NFL Mobile updated for 2014 Season with new Fantasy Football features, NFL Now integration


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Jennifer wants to be a great mom, plus more from Tracy Morgan, Lindsay Lohan and others
Updated: Friday Oct 12, 2007 | 06:00 AM EDT
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"My wife don't want to let them grow up and leave, 'cause then she's stuck with me!" – Tracy Morgan, on feeling his children, aged 16 to 21, are old enough to leave home on The View
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Sweet family session from back in February….Nicole was a doll. Happy Weekend!
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I see many posts about getting the best distance out of your battery by driving slow speeds on highways with maximum speed limits of 70 or more.
The "don't use cruise control it's to inefficient"
I'll let you know right now in Missouri if you coast up hill at speeds below 60 (actually in most cases under 70 outside the city) then coast down the next one at whatever speed the car will go, you will get run off the road by drivers going up the hill and you will get ticketed going down the hill when speeding. There were 3 cops on hwy 44 on my way back from a road trip last week. I did not get a ticket (I let the cruise do it's job) but they were ALL on the downhill stretch. The highway has two lanes of traffic each way. If you are in the slow lane you are behind a large truck going slow all the way up the hill, no advantage. So even ICE drivers who play this game to conserve fuel use the fast lane to coast up hill. That even annoys me.
Driving the perfect speed for distance:
Few people are going to get excited about buying a Model S for the price it sells at when they see them on the highways with posted speed limits of 70 MPH or more and the car is going 55-60 to conserve battery. The car will get classified as a overpriced large Yugo with good looks.
Driving around in hot weather with the A/C off, windows up or down, is a joke. Again no one is going to want a car for over $70k when they can't use the A/C on road trips.
Don't shoot me. I am just the messenger.
I am severely and sincerely puzzled by those policies. Usually a targetted tax like that is intended to discourage some thing, in favour of an approved alternative. What is the alternative? Public transport? Shank's mare (walking)? Minimizing travel/movement?
Or is the road network especially difficult to maintain, and "long per capita"?
The other major possibility is that the gubmin sees autos as an "inelastic" target that people are going to buy regardless, making them a reliable source of revenue.
Edit: gubmin = gubmint (= governing mint?)
"MandL | SEPTEMBER 20, 2012
While I don't really WANT to drive 300 miles in a day, I often will. I doubt I'm that unusual either."
Don't doubt it, you are unusual. If you don't think so, I'm guessing you must know a lot of truckers or something.
Or Travelling Salesmen. ;)
Or Nomads, Gypsies and Mad Max??
mrspaghet -- How many people want to drive 300 miles per day
I'm not sure where you reside, but 300 miles in Texas will hardly get you out of town. I avoid driving more than 700 miles per day, so I try to make a day's driving 600 to 750 miles.
My wife is wanting to go to Disneyland within a few days of getting the Model S. For us this is a hop of roughly 200 miles then over a significant hill and down into the LA basin with 255 miles. So 200 miles, find a recharge port, then 120 miles to Bakersfield and charge at a Nissan or Mitsubishi dealership (HA!) or an RV park. Then 140 miles including the significant climb and then coast into the LA basin.
The 200 mile hop is to stop by my parents place on the way down. Otherwise I'd plan on a stop by Harris Ranch and have lunch then continue down the road (roughly same difference) to an RV plug near Bakersfield.
Going 55 mph vs 70 mph makes zero difference to these plans. ZERO. I'm only going 200 miles at a hop, not 270 miles.
It is all in the planning. If I was driving my ICE (Jetta TDI) then I'd go the 200 miles, get some diesel, then go over the hill and look for a refill near LA. The main difference for the Model S is worrying about getting over the hill without waiting on a 120V charge. Charging off a J1772 or NEMA 14-50 is the 120 mile recharge point and that's a couple hours just to get ~60 miles of charge for the climb.
@Jerry3: I'm in TX too, and I stand by my prior comments. The driving patterns you are describing are unusual.
@Jason S: "it is all in the planning" - Couldn't have said it better myself.
As it turns out, one of the new supercharge stations is at Laval Rd and I-5... so that's my Bakersfield stop. SWEET!!
I can stop there for lunch and make it easily all the way to Anahiem from there.
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PLSB has been on the uptrend from .40-70 and is looking to really catch steam. I'm initiating a long position as they are a LEGITIMATE company with good #'s. There have been buyout talks and its one year Target has been set at $4-5.
PLSB is likely to double short term and be worth $3-5+ mid term. They have revenues, a hot sexy product, great packaging and just everything going for them.
PLSB is NOT a stock promotion but a LEGIT business with a REAL product and REAL revenues. I wouldn't be suprised to see it trading near 5 dollars by September.
I can really see PLSB being the next vitamin water type product to get bought out within the next year. Mid term this is a HUGE winner and potential is limitless.
PLSB is going to be a staple in the sports beverage industry within the next year. Their products are undeniable.
PLSB is a prime Target for a breakout in the next few weeks and I mean a rampage the way this thing is consolidating.
I have read and heard PLSB has been in recent talks with Coca Cola and Pepsi if this is indeed true this future run up could be tremendous .... Do your DD.
Beverage companies have been some of the biggest % gainers in the history of wall street. I really believe PLSB is a long term winner. Great company!
PLSB is making new highs. Every day its been sneaking upwards. I'm adding to my long term position here in the .70's.
PLSB chart is looking great for the long term with an increase in volume and nice uptrend. Many new highs to be made here
Volume is gradually increasing in PLSB as Long Term investors see the companies potential for growth and to LEGITIMATELY be potentially bought out within the next year.
CocaCola will aquire PLSB within a year, I willing to put my money where my mouth is. Their numbers and products just don't lie. Up and coming company for sure.
I've been holding PLSB from the mid .50's and have added in the high .60's. I set a .60 stop loss and I'm going to continue to add anything under $1.00 and hold long term as I feel huge things arpp coming.


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Nowhere to go? Know where to go!™
Sochi is one of the few cities in Russia that has its own unique, multicultural cuisine, with influences from bordering Georgia. During the 16-days of the Olympics, Washingtonians will enjoy: 1) Shish Kabob ($22), cubes of marinated beef, 2) Solyanka Soup ($11), a spicy soup with cuts of meat and chopped vegetables, and 3) Khachapuri ($21), a traditional Georgian dish of cheese-filled bread.


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wxMP3gain was specially designed as an Open Source automatic MP3 volume normalizer.
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This free mp3 cutter and editor is an extremely simple and handy tool for routine mp3 editing tasks.
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Red cards for goalscorers Wayne Rooney and Paul Scholes marred United's 3-1 victory over FC Porto in the Amsterdam Tournament on Friday night.
The lingering concern is that Rooney and Scholes could now miss the start of the Premiership season. If the referee includes the incidents in his report to the FA then both could receive suspensions.
The Reds were made to work for the win in the team's toughest test so far in pre-season. Ole Gunnar Solskjaer capped off the win with United's third before Pepe grabbed a late consolation. United earned six points for the victory at the Amsterdam Arena due to the competition's scoring system, in which points are awarded for each goal scored.
United were forced into a change before the match had started, with Rio complaining of a sore ankle during the warm-up. John O'Shea replaced him alongside Wes Brown in the centre of defence and performed well.
Porto began the game brightest, with 18-year-old midfielder Anderson dictating play in the middle of the park. But, after 11 minutes United took the lead. New signing Michael Carrick's corner found Scholes on the edge of the box. The in-form midfielder controlled the ball, feigned to shoot, shifted the ball onto his left foot and cracked his shot into the bottom corner. Porto keeper Helton didn't even move.
United were fortunate to be in front, but were even more fortunate after 19 minutes when Brown needlessly put van der Sar in trouble with a weak backpass. Only a sliding challenge from the Dutch goalkeeper prevented an embarrassing equaliser.
A minute later, United doubled the lead thanks to Wayne Rooney's determination. He lost the ball but regained possession and raced through on goal. Helton went to ground early and Rooney delicately lifted the ball over the despairing keeper's reach.