text:
The 2011 Observer Music Award Winners
By Pete Freedman
The Best Of Dallas 2011: Food, Bars and More
By Dallas Observer
The Best of Dallas 2011: The Ultimate Guide
By Dallas Observer
Exonerated prisoners say their lawyers are ripping them off.
By Brantley Hargrove
By City of Ate
Presenting: The Best of Dallas Readers Poll!
By Dallas Observer Staff
Smoke's Tim Byres Menu for City of Ate's Supper Club
By Seth Cohn
Flaming Lips' Wayne Coyne On Regionalism, Gummy Skulls...
By Pete Freedman
If you've got Scottish blood and find yourself in dire need of the lowland "tuxedo" of your native land, all you need to do is call Barbara and Charlene McGowan and schedule a visit to their in-home shop in Arlington. Their kilts, commissioned from a kilt-maker in Scotland, are the real deal and come with all the accessories--the sporran (leather purse) and the sgian dhu (the small dagger traditionally worn in the sock). The entire outfit can run as high as $1,000, but who's counting? In business since '91, the McGowans annually hold a July 1 bash to commemorate Scotland's repeal of the ban against kilts back in 1782, serving up food from the homeland and a contest to determine which kilt-wearer has shown up with the best knees.


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The Fabrikam sample company is deployed via GP Utilities. Log into it using the sa account and progress through to the Additional Tasks. In the drop down list select Add sample company data and click :
GP Utilities
Microsoft Dynamics GP 2013 SP2 Web Client Scale-Out Deployment: Installing The Server
Now we have a client installed, we can use this to install the server. To do this run GP Utilities and log in using the sa account:
Microsoft Dynamics GP Utilities – Install Of Database Failed
I was asked to create a new company for a client recently, who is still running Microsoft Dynamics GP 9, which should have been an easy task. However, when I tried to run GP Utilities to create the company I received an error:
I did a bit of exploring and testing of the system, but couldn't identify the problem. I then tried to search online and did come across a Microsoft Knowledge Base article but it was of no help. I finally decided that the problem might be the client installation I was using.
As mentioned, this particular client is still using Microsoft Dynamics GP 9 which had a separate server components install (they are in the middle of an upgrade project to bring them to the latest version) which complicated things a little as I couldn't just use any other client.
Instead, I made a did a backup of their DYNAMICS system database and loaded it onto a VM with SQL 2000 and GP 9 SP3 already installed. I was able to use the GP Utilities in the VM to successfully create the company.
That done, I backed up the system and company database and restored them to the clients live SQL Server before anyone started work in the morning. This approach is a little roundabout, but it was a little easier than reinstalling the client on the server and meant I didn't risk disrupting anything.
How To Install Microsoft Dynamics GP 2013 – How To Create A Company
The Microsoft Dynamics GP sample company, which I showed how to install in the last post, is good for doing a demo or for testing, but in the real world most sites will never deploy the sample company. Instead their efforts will be focused on creating a company to host their own data, which is what we're going to take a look at in this post.
New companies are created using GP Utilities () and login using the sa password;
How To Deploy The Demo Company In Microsoft Dynamics GP 2010
In the last couple of posts, I showed how to configure the server of Microsoft Dynamics GP by creating the System database and how to create a new company. In this post I'm going to run through deploying the Fabrikam, Inc. demo company.
To create the company, open GP Utilities () by right clicking and select Run as Administrator. Log in as the SQL System Administrator (sa);
How To Create A Company In Microsoft Dynamics GP 2010
In the last post, I showed how to configure the server of Microsoft Dynamics GP by creating the System database. In this post I'm going to run through the company creation process.
To create the company, open GP Utilities () by right clicking and select Run as Administrator. Log in as the SQL System Administrator (sa);
How To Install Microsoft Dynamics GP 2010 – Server Configuration
In the last post I explained how to install the Microsoft Dynamics GP client and in this one I'm going to cover the server configuration. There is no server installation as such, as this can all be done from any client installation of Microsoft Dynamics GP.
To configure the Microsoft Dynamics GP server, right click on GP Utilities and choose Run as Administrator () and log in as the SQL System Administartor (sa);
Unknown Error Creating Demo Company
This is another mea culpa post; I've been doing enough of them I'm thinking of giving them their own tag.
I was created a virtual machine with the Fabrikam, Inc. demo company in it. When GP Utilities was processing I got this error pop up;

subset: commoncrawl


text:
The work of the association relies on the many contributions of members such as you. Volunteer leaders are the mainstay of any professional organization.
The Academy's Nutrition Care Manual is a comprehensive online resource that covers all aspects of nutrition management. NCM's user-friendly resources include:
Learn more »
Special Feature
The Nutrition Care Process in Pediatric Practice
This easy-to use guide shows how to incorporate standardized language—the International Dietetics & Nutrition Terminology (IDNT)—into everyday pediatric practice.
« Back To Eat Right Weekly - July 6
Members attending ADA's Food & Nutrition Conference & Expo can maximize their valuable time in the Expo Hall by first learning about the companies who will be exhibiting their products and services in San Diego.
ADA's FNCE website lists more than 300 exhibitors alphabetically, by booth number and by product category. Members can use this information to:
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Photos: Fans and players bundle up with the exception of a few, SMU flag finds home in snow, Mustangs can't finish upset
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text:
The Press Newspaper
The Press Newspaper
Bulletin Board policy
Turkey Dinner & Bazaar Nov. 7, 5-7 p.m., Clark Street Church, 1133 Clark St. Complete dinner including beverage and dessert. Carryouts available.
St. Lucas Annual Kraut and Pork Dinner Nov. 9 at the church, 745 Walbridge Ave., near South and Broadway. Dinner includes mashed potatoes and gravy, noodles, applesauce, dessert and drink. Dine in at 6 p.m.; carry out at 5:30 p.m. For reservations, contact the church office at 419-243-8189.
Waite High School Blood Drive Nov. 9, 8 a.m.-1:30 p.m. in the Field House, East Broadway Street. Walk-ins are welcome but appointments are available by calling the school at 419-671-7000.
"Homespun Holiday Art & Craft Show" Nov. 10 from 10 a.m.-5 p.m. and Nov. 11 from 10 a.m.-4 p.m., Stranahan Great Hall, 4645 Heatherdowns Blvd. Free admission and parking. Featuring handmade crafts, gifts and decorations.
Ohio State/Michigan Chili Cook-Off/Tailgate Party Nov. 16, 7-11 p.m., St. Thomas Aquinas Gym, corner of White and Idaho. Admission includes chili, hot dogs, chips, cheese tray, snacks and more. Entertainment, raffles Big Six/Horserace and more. Bring OSU/Michigan decoration for the Best Dressed Table Contest. Chili registration at 6 p.m. Doors open at 6:30 p.m. Adults only. Call Tim McCrory at 419-343-7798 for info. Tickets also available at the church rectory.
Wine Tasting Dinner & Silent Auction Nov. 16, 6:30-9 p.m., St. George Cathedral Hall, 3754 Woodley Rd. Participants can taste an assortment of wines, foods & desserts. Cost is $50 per couple. Proceeds will go toward the Church School Building Fund. For info, call the church at 419-475-7054 before 2 p.m.
Block Watch Meetings for East Toledo Raymer Elementary area, 410-M (and temporarily also 410-P), are held the 2nd Thursday of each month, at 6 p.m. except Dec. and Jan. or in weather below 20 degrees. Meetings are held at Memorial United Church of Christ, 1301 Starr Ave. Lighted parking is available at the lot off White St.
Mercy St. Charles Hospital Auxiliary Prize Bingo Wed. Nov. 7. Doors open at 6 p.m. Bingo runs from 7 to 9 p.m. Many prizes and raffles. Admission: $5 donation. Info: Bev at 419-836-9146.
All-You-Can-Eat Spaghetti Dinner, Nov. 10, 4-6 p.m., First St. Mark's Lutheran Church, 1121 Grasser St. Includes salad, dessert and beverage. 50/50 raffle. Wheelchair accessible; carryouts available. Info: 419-693-4578.
Theology with Toast meets the 2nd Wed. of the month at 10 a.m. at the Little Sisters of the Poor, 930 S Wynn Rd. Nov. 14, Kathy Haninger will present 'Jesus was a Young Adult.' Coffee and rolls at 9:30 a.m. Info: Alice at 419-698-0405.
Oregon-Jerusalem Historical Society, 1133 Grasser St., is open Thursdays 10 a.m. to 2 p.m. Visitors may browse through the complex at their leisure. Free; donations welcome. Info: www.ojhs.org.
ABLE (Advocates for Basic Legal Equality) Mobile Benefit Bank will be at the Oregon Branch Library the 2nd Wed. of every month from 2:30-5 p.m. to assist people with basic legal issues and applications for public benefits.
One-on-One Computer Training available by appointment at Oregon Branch Library, 3340 Dustin Rd. Registration required by calling 419-259-5250. Classes offered Thurs. at 2 p.m. and Sat. at 9:30 a.m.
Oregon Area Pastors Fellowship Pastors' Luncheon held the first Wed. of every month, noon, American Family Table on Wheeling.
Book Discussion Group meets every 3rd Tues., 1 p.m., Oregon Branch Library, 3340 Dustin Rd. 419-259-5250.
"James Wes Hancock" Oregon Senior Center, 5760 Bayshore Rd., open weekdays 9 a.m.-3 p.m. Daily activities include: bingo, fitness classes, line dancing, exercise, Bunco, Euchre, and health screenings. Lunch served at 11:30 a.m. daily. $2.50 donation is suggested for seniors 60 & older; all others $5.32. Reservations required 24 hours in advance. 419-698-7078.
Sunoco Retirees meet for lunch the 1st Mon. of each month, 11:15 a.m., Bayside Boardwalk, 2759 Seaman Rd. Reservations: Al McEwen 419-893-3075.
East Toledo/Oregon Kiwanis meet the 2nd & 4th Mon. of the month at noon in the basement level at ProMedica Bay Park Hospital. 419-693-4458.
Toastmasters Club meets the 1st & 3rd Tues. of each month, 6:30 p.m., Lake Michigan Room, ProMedica Bay Park Hospital. Visitors welcome. Info: Julie at 419-836-5051/Allen at 419-270-7683 or visit d28toastmaster.org and click on "Great Eastern Club."
Maumee Bay Country Quilters' Guild meets the first Tues. of the month in the Board Room at Mercy St. Charles Hospital at 6:45 p.m. Guest fee for the meeting is $5. Persons having questions concerning this meeting or the guild may call 419-693-8173
Jerusalem Twp. Food Pantry, open 2nd Wed. of every month, 9-11 a.m. at the township hall, 9501 Jerusalem Rd.
Northwood VFW 2984 Feather Party Nov. 10, 6 p.m., Featuring bingo & 50/50 raffles. Turkeys, hams and steaks. Public welcome.
Crafters Wanted for a Holiday Craft Bazaar Nov. 16 and 17 at Unity United Methodist Church, 1910 E. Broadway St. Table rental is $20/table for two days. Info: call Jan at 419-666-0481.
Northwood VFW 2984 Taco Nights Mondays 4-7:30 p.m. Fish Frys featuring fish, chicken, steaks and shrimp are held Fridays from 5 to 7:45 p.m.
Gun Raffle sponsored by Northwood VFW Post 2984. First prize is a WW II commemorative M1911A1 .45 and a Thompson sub-machine gun. Second place wins $500 and third place wins $100. Tickets are $20. Only 1,000 tickets will be sold. Call 419-666-7762 for ticket info.
Storytimes for Preschool-Age Children offered Wed. at 11 a.m., Harris-Elmore Library, 328 Toledo St. Book discussion group meets the 4th Thurs. of each month at 10:30 a.m. New members welcome. Info: 419-862-2482.
Elmore Senior Center-Elmore Golden Oldies, Grace Evangelical Lutheran Church, 19225 Witty Rd. Lunch served Tues. & Thurs. at noon. Reservations required by 10 a.m. the day before. Blood pressure & blood sugar checks the 4th Tues. of the month; bingo the 4th Tues. of the month after lunch. Reservations: 419-862-3874.
Elmore Card Players Meet Thurs. evenings at 7 p.m. at the Elmore Retirement Center.
Free Veterans Breakfast Nov. 11, 9:30 a.m., Genoa Trinity United Methodist Church. Attendees may stay for a special Veteran's Day worship service at 10:30 a.m. RSVP by leaving a message at church at 855-3575.
Our Lady of Lourdes Feather Party Nov. 11, 4-7 p.m. Play bingo in the church hall to win turkeys, hams and chickens. Win raffles and door prizes. Soup, pizza, hot dogs and desserts available for purchase. Kids' bingo with prizes for $2 all night. Proceeds will help fund the Religious Education Program.
Free Computer Classes offered at the Genoa Branch Library through Connect Ohio. Series includes three classes that will meet from 10 a.m. to noon. Topics include: Computer Basics, offered Oct. 25; Internet Basics offered Nov. 1 and Email Basics offered Nov. 8. Class size limited to 10. For info, call 419-855-3380.
Friends of Genoa Branch Library are selling book bags in five different colors at a cost of $4. A bag is included with a paid membership of $15. Info: 419-862-2482.
Preschool Storytime meets Tues. at 11 a.m. at the Genoa Branch Library, 602 West St.
Genoa Civic Theatre & Literary Society is seeking vendors for a Craft Bazaar Nov. 17. For info, call 419-704-5585.
Book Discussion Groups meet the 3rd Thurs. of the month at 9:30 a.m. & the 3rd Tues. at 7 p.m., Genoa Branch Library, 602 West St. Call 419-855-3380 to reserve a book.
Genoa Senior Center 514 Main St., serves lunch Mon., Wed. & Fri., 11:30 a.m. (call 419-855-4491 for reservations). Card playing Mon. & Wed. at 12:30 p.m.; blood sugar checks offered the 3rd Wed. of the month; bingo Mon. at 9:30 a.m. Trinity Thrift Shop, 105 4th St., hours are Fri. 9:30 a.m.-4 p.m. & Sat. 9 a.m.-1 p.m. Clothes & small household items available at reasonable prices. Proceeds benefit mission projects.
Genoa Community Food Pantry Open monthly on the 3rd Thurs.3:30-5:30 p.m. and the following Saturday of the same week, 10 a.m. - noon. Serving those who are in Genoa School District. Proper ID and billing within the district address required. Pantry is located at Trinity United Methodist Church, 4th & Main. Info: 419-855-3575 or 419-855-8539.
Mobile Food Pantry sponsored by the fire department auxiliary every 3rd Mon. of the month, 5-7 p.m., Fire Station 1, 4505 Walbridge Rd.
Lake Twp.Police Officers Association spaghetti dinner, Nov. 2, 5-7 p.m. at the township hall, 27975 Cummings Rd. Carry-outs available.
Free Meal 4th Mon. of each month, American Legion Post 240, 335 Park Dr. Serving 5:30-6:30 p.m.
Food Pantry open to the public the last Wed. of the month, 1-3 p.m. & the last Thurs. of the month 6-8 p.m., Main St. & Krotzer Ave. Contact local church offices for info.
Craft/Vendor Show Nov. 10, 9 a.m.-2 p.m., St. Paul's UMC, SR 795. Building is wheelchair accessible. Free admission. Luncheon available.
Swiss Steak Dinner Nov. 7, 4-7 p.m., St. Paul United Church of Christ, 165 Toussaint St. Serving Swiss steak, mashed potatoes and gravy, corn, applesauce or cole slaw and homemade pie. Children's (half-portion) meals available. For tickets, call the church at 419-898-0852. Dine in or carry out.
Ottawa Co. PERS Chapter 82 Luncheon Meeting Nov. 12 at the Mill Street Brews, 169 Mill St. Speaker will be Mark Shieldcastle from Black Swamp Conservatory. Reservations required by Nov. 9 and may be made by calling 419-898-5544 or 419-855-8131.
Food for Thought Food Pantry at Oak Harbor Alliance Chapel, 11805 W. SR 105, the last Wed. of each month from 5 to 7 p.m. Info: 419-707-3664.
Community Food Pantry at Bethlehem Lutheran Church, 220 Cedar St. open M-Th, 11 a.m.-2 p.m. (excluding holidays). Open to Eastwood School District residents. ID & proof of residency required. Info available at Pemberville churches.
Walbridge Centennial Committee meets the second Tues. of each month at 6:30 p.m. Village of Walbridge hall.
Family Storytimes for children of all ages Tues. 11 a.m., Walbridge Branch Library, 108 N. Main St. Free. 419-666-9900.
Solomon Lutheran Annual Holiday Bazaar, Nov. 17, 9 a.m.-3 p.m. The church's "famous lunch" will be served from 11:30-1 p.m. Visit solomon-lutheran-school.com or call 419-849-3600 for info. Applications for vendor participation are also available on the website.
Sinclair Handbell Choir, from Sinclair Community College, Dayton, in concert, Nov. 30, 7 p.m., Woodville U.M. Church, 201 W. First St. Presenting holiday music played on Schulmerich Handbells and Malmark Choir Chimes. For info, call the church office at 419-849-2400 or Terri Molter at 419-849-3004.
Woodville Senior Center offers lunch M-F, 11:30 a.m. (call 419-849-3636 for reservations). Home delivery also available.
Most Popular
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Christmas spending
Are spending more, less or the same amount this year for Christmas?
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977623603 [{"id":"27","title":"More","votes":"0","pct":0,"type":"x","order":"1","resources":[]},{"id":"28","title":"Less","votes":"1","pct":50,"type":"x","order":"2","resources":[]},{"id":"29","title":"The same","votes":"1","pct":50,"type":"x","order":"3","resources":[]}] ["#194e84","#3b6b9c","#1f242a","#37414a","#60bb22","#f2babb"] sbar 160 160 /component/communitypolls/vote/12-christmas-spending No answer selected. Please try again. Thank you for your vote. Answers Votes


text:
mangle1Line breaks: man¦gle
Pronunciation: /ˈmaŋɡ(ə)l /
verb[with object]
1Destroy or severely damage by tearing or crushing: the car was mangled almost beyond recognition
More example sentences
- The smooth shell of the car was mangled beyond recognition.
- Two crushed and mangled pick-up trucks have been flipped on their side.
- The dais was in the form of a human whose skeleton was mangled beyond recognition.
1.1Ruin or spoil (a text, piece of music, etc.): he was mangling Bach on the piano
More example sentences
- Actually, I don't think they physically cooked anything, they just stood around and watched their recipes being mangled by the in-house excuse for a chef.
- It then goes on to mangle the line 'will things ever be the same again?'
- This got me thinking about how some mangled enunciation has become par for the course in pop music, and we don't really think it's weird anymore.
spoil, ruin, mar, mutilate, bungle, mess up, make a mess of, wreck
informal murder, make a hash of, muck up, screw up, butcher
late Middle English: from Anglo-Norman French mahangler, perhaps a frequentative of mahaignier 'maim'.
- 1
mangler noun
- Example sentences
- Humphrys has now let his rage against the army of word manglers off the leash.
- My resolutions, therefore, are for others, and in particular for some of the many manglers of the English language.
- For each national-anthem mangler, there was only one rendition standing between glory and defeat.
Definition of mangle in:
- US English dictionary
- English synonyms
- US English synonyms
- Spanish dictionary
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mangle2Line breaks: man¦gle
Pronunciation: /ˈmaŋɡ(ə)l /
A machine having two or more rollers turned by a handle, between which wet laundry is squeezed to remove excess moisture.
Example sentences
- 'If I wasn't at school, I had to turn the handle on the mangle while mum put the sheets through,' Peter recalls.
- She does not have a TV and her washing machine is an archaic model involving rubber hoses and a handle-operated mangle.
- The garden also contains a vintage mechanical washing machine as well as antique ploughs, mangles and bacon slicers.
verb[with object] Back to top
late 17th century: from Dutch mangel, from mangelen 'to mangle', from medieval Latin mango, manga, from Greek manganon 'axis, engine of war'.
Definition of mangle in:
- US English dictionary
- English synonyms
- US English synonyms
- Spanish dictionary
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text:
Weather Links
Humidity 80%
Winds 5.8mph
Sponsored by: Arceneaux Ford
Humidity 80%
Winds 5.8mph
Jan 24, 2013 12:55 PM by Ian Auzenne
Ville Platte police are investigating a body found in a residence. Officials say friends of John Early found him dead in his home Monday. Investigators say Early had been drinking the night before and had been involved in a fight before walking home. Autopsy reports are pending, and the case remains under investigation.
10 hours ago


text:
Kiss Crazy, Crazy Nights Lyrics
Last updated: 09/17/2012 02:10:39 PM
(Whoow! Here's a little song for everybody out there)
People try to take my soul away,
but I don't hear the rap that they all say
They try to tell us we don't belong,
that's alright, we're millions strong
This is my music, it makes me proud,
these are my people and this is my crowd
These are crazy, crazy, crazy, crazy nights
These are crazy, crazy, crazy, crazy nights
Sometimes days are so hard to survive,
a million ways to bury you alive
The sun goes down like a bad bad dream
You're wound up tight, gotta let off steam
They say they can break you again and again,
if life is a radio, turn up to ten
[chorus repeats 2x]
And they try to tell us that we don't belong
But that's alright, we're millions strong
You are my people, you are my crowd,
this is our music, we love it loud
Yeah, and nobody's gonna change me,
'cos that's who I am
[chorus repeats out]
Thanks to email@example.com for submitting Crazy, Crazy Nights Lyrics.
one more thing | Reviewer: Natasha | 9/15/12
my dad or uncle had a thing that had KISS music videos on it (i dont know what their called or i cant remember at that moment).they had a bunch of those not justt KISS.tecnically yesterday my mom had to work so we went to my grandmoms house and me and my sisters were alone because my great grandmom is at a old people place cause she had hip surgery and my grandmom was at work at my uncle dropped off food at his girlfriens house so i took a bunch of tapes and what i was talking about earlier.i took a poison one and a KISS one.i wouldve taken more but i didnt want to clear it out in case someone decided to look.i pretty much stole from them but they are family.i was thinkin bout yje episode of tanked with KISS cause it was on when i was writing this and they were having this episode where they go through episodes that have to do with the family and they had scens from the KISS one during the father and son part cause the general lost a bet and had to drrrress up blike gene simmons.
I LOVE KISS!!!!!!!!!!!!! | Reviewer: Natasha | 9/15/12
KISS is my favorite band ever since i saw KISS Meets The Phantom Of The Park when i was like three or something.i was born in August 2000 so i am not growing up with great music.my favorite bands are from the 80's or older.i listen to stuff half the people at my school havent even heard of.i was watching metal mania once and they played this somg and i was REALLY excited!!!anyway today i was watching metal mania and during a commercial break i was telling my sister (who doesn't like music from the 80's that much mainly cause they have long hairr and looked like girls.she sucks.)that they played it and she said she never hard it and i was like WHAT!!??i said it would be wierd if after the break They would have that song abd after the break KISS was on but they wereplaying forever.i was like THATS SO WIERD!!!!
Crazy Crazy Nights | Reviewer: Jenn | 8/10/07
I've been a fan since I was old enough to know who they were, Gene was my first "Hollywood Crush" (no it had nothing to do with the tongue I was 13 for Goddess sake) and my Mom had bought the tape Crazy Nights for me for getting Honor Roll in High School the first time I heard this song, I knew I loved it, it felt as if they were singing about my life. You see I was badly criticized for being a KISS fan in High School, but it never stopped the love of them and their music, finally when I was 17 I saw them live for the first time. When Gene came out on stage, I started screaming to him and he looked at me, I thought I was going to die of joy. That was the best concert I'd ever seen, unfortunately they didn't do Crazy Crazy Nights but it was still a night to remember. I'll never forget it and even though I no longer have the infatuation with Gene I still love their music and Gene will always be my biggest role model, he saved my life a few times (indirectly of course) and he'll always have a special place in my heart, they all will.
KISS IS AWESOME | Reviewer: Bob | 6/29/07
Dude, this song is awesome. It's about how your music sucks and Kiss rocks. Which is true :D
KISS ROCKS | Reviewer: brendon | 2/26/07
I am one of the nights for as long as i live and i will love em for that long, just remember God Gave Rock N' Roll to us all!!!!!!!!
Huge fan brendon
KISS RULE!!! | Reviewer: Jamie | 3/19/05
Kiss rule so every1 go out and buy it coz its fukin mint so rock and roll all nite and party every day :D:D:D


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Girls and Guys, How Fast Can You Cum?
So, I know fast cumming is not generally wanted. If I want to I can go for a long time, but I was talking on the phone with a good female friend of mine today, we were not being sexual at all and I was completely soft, but I wanted to jerk off. We are just friends by the way, but we are open about stuff like this, even tho we would never do anything sexual with each other due to being too good friends. Anyway. So I am talking to her, and she wants me to get online to play this game with her, but I told her no, I want to jerk off first, cause I was planning on doing that. So she tells me I have 5 minutes to do that or else she is going to play without me. So I told her to count to 200 seconds and if I do not come by then I will stop and play. She asks if I am ready, I put my hand in position and she tells me to go. I come after 150 seconds, going from soft to hard then cumming.I know really odd story, but I was really proud I was able to pull that off. So I am wondering how fast can you guys and girls go until you cum.
This question has a poll!
What's Your Opinion?
Most Helpful Opinion
Not at all for some reason.
Have you masturbated? Like nothing may come out, but you should feel a release or something.
Nope it feels good the things that my boyfriend does to me but it doesn't feel like what everyone says it feels like, he has trouble to for some reason ill be going at it for an hour and still he won't cum.
What Girls Said 5
Well the climax gets bigger each time. I find on a regular day, maybe 10 minutes. If I've already had sex the day before or 2 days before it's harder to cum. Since I haven't had sex in about 8 months, I imagine my next one should be quick.
Why wait such a long time, don't you have urge to masturbate?
Well my boyfriend and I are celibacy thing. I'm too lazy to masturbate. It's sad but true. My boyfriend might get a little hand job every once on a blue moon but that's as much sex as I have normally.
That sucks, too lazy to masturbate lol
well , I thought I would try it so I could give you an accurate answer, and it was 1 min 43 seconds. who-hooexcept now I have a really bad wrist cramp...lol
Damn, impressive. Sorry about your wrist, I would probably have gotten one if I did that to you that fast too lol.
Interesting - That is some great turn around time.
i can come in about 5 minutes or less if I really focus. generally though it takes 5 to 15 depending on how turned on I am. ;]
Lol, well we can always try, ill help turn you on! lol
Yeah it doesn't take too much..i get really hot really fast..mmm I'm getting turned on just thinking about it..i might need to make me a booty call! haha =D
LOL well I am here if you need me to talk dirty. I do have a **** don't ya know lol


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Amalfi Waterfront Vacation Rentals Vacation Rentals(16)
16 Results
Recent Amalfi Reviews
Exactly as pictured!
We almost didn't want to go out in the evenings as the view on the patio was fantastic. Lots of stairs but again no surprise as this is Amalfi and the web site indicated this. Some very good suggestions were given for places to eat and all were outstanding and reasonable. It seems that everyone in Amalfi is very friendly. There were 2 couples that rented Afrodite and we all enjoyed the stay. Very nice and quiet location.
Stunning Views
We stayed at this property the first week of May 2014. The provided pictures accurately depict the property and its furnishings. It is not a stand alone villa, but more in the nature of a portion of a larger premises (it is a little hard to describe, as a calling it an apartment is not quite accurate either). In any event, it gives the place an " authentic" local feel. As stated in the description, there is a private patio area as well as balconies off the main bedroom and living room. The views are stunning and will take your breath away. The third bedroom is separated from the main quarters, 10 or 15 steps down with a separate entrance. As clearly stated, the property is not suitable for anyone who has difficulty with steps (102 of them). However, I am over 60 and had no problems whatsoever with them. The GAS Bar is located at the bottom of the steps, where you can buy tickets and take the bus to town. There is a roof top restaurant at the GAS Bar which has good casual food. The roof top views at the restaurant rival any in town. We walked to town. It is about a 20 to 30 minute downhill walk. Probably faster if you don't frequently stop to take pictures or take in the view. You do have to walk on the side of the road in several areas where there is no walkway. This was not an issue, although I would not do the walk in the dark even though we did see others on the road after dark. When you come to the first tunnel, veer to the walkway on the right and you will come to steps that will lead you right to Amalfi's waterfront. We took taxis back (the uphill walk would undoubtedly be harder). For 5 people the taxi cost was usually Euros 15. Since this was our first visit to the area, we were out most of the time. I wish we could have spent more time just sitting on the patio drinking limoncello and taking in those beautiful views. Next time! I would happily return to this property again.
Wonderful Seaside property in Amalfi
We rented the two apartments for our family (top and bottom, separated by about 20 external stairs). The owners stay in the middle flat but we rarely saw them, so privacy was not an issue. They offered to let us pick a few of the lemons growing on the property, which was a treat for us. They knew from our passport info that our daughter was having a birthday that week- Lena (owner) actually surprised her with a homemade and delicious tiramisu cake! The flats were very clean and well maintained. Kitchen was designed for light cooking only (countertop oven). Two of the three beds were very hard, which I found uncomfortable. It was fabulous to be able to go down the steps to jump in the water. There was a ladder to get back up- property is not suitable for young children. I am in my 50s and managed the many steps just fine. The property, including the car parking, is gated. We parked our car and bused to the nearby towns. SITA bus tickets are available from the gas station almost across the road and the bus stop is within 50' of the property. Wonderful property with lovely views of the sea and a great location from which to explore the Amalfi coast.


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Today's Citizen
Tories back down
The federal government will reverse plans to end party funding, Transport Minister...
Canada orders 1,300 smart bombs
$100,000-apiece weapons to be used in Libyan mission
David Pugliese, Ottawa CitizenPublished: Wednesday, May 18, 2011
NATO is operating with the blessing of a UN Security Council Resolution that sanctions force to protect Libyan civilians.
But some countries, such as Russia and China, have raised questions about whether NATO has gone far beyond the mandate authorized by the UN. Russia accused NATO of meddling in Libya's internal affairs.
Defence Minister Peter MacKay said Canada has no intention of sending more planes or expanding its role in Libya. "We know that Gadhafi is now entrenching, but the reality is were going to stay within the parameters of the Security Council resolution and we have put forward, in my view, an exceptional effort on behalf of our country," MacKay said on the weekend.
Canada has committed 560 personnel, seven fighter aircraft, two refuelling planes and two Aurora maritime surveillance aircraft to the mission. In addition, a frigate is also assigned to the conflict and is patrolling the Mediterranean to enforce an arms embargo on Libya.
There haven't been any discussions on how long Canada's efforts will be required. Parliament is expected to re-examine the mission in June.
On April 15, the Washington Post reported that Britain, France and other countries involved in the Libyan war were running low on stocks of laser-guided bombs.
Pike said NATO nations appear to have been caught off-guard in not having enough bombs on hand. He said the focus for such countries is usually on the multibillion-dollar fighter aircraft, but that having enough weapons is key to fighting any war. It's like buying a car without the tires, he said of having aircraft without enough munitions.


text:
The Jonas Brothers and Demi Lovato Sign on for Camp Rock 2: The Final Jamby Matt Richenthal at . Comments
Get ready to scream with excitement, teenage readers:
The Jonas Brothers and Demi Lovato will team up again in a sequel to Camp Rock, the Disney Channel hit from June 2008.
Look for Camp Rock 2: The Final Jam to begin production this summer and debut next year on the same network.
In it, the characters played by Lovato and Kevin, Nick and Joe Jonas return to Camp Rock, only to discover that many of the students and instructors have ditched it for nearby rival Camp Star. Uh-oh!
Other actors returning for the sequel include: Meaghan Jette Martin, Maria Canals-Barrera and Alyson Stoner.
You Might also Like
that was really amazing!!!!!!!!!!!!!!!!
Los y demi son lo mejor
your so cute demi we love you
i am relly so exied to see you.
demmy alexa no teaga tu ere una loca no teapene ere una loca vasosalosieto demmy novato
att;una gete
yes number 2 number2


text:
GU17 repeat as state cup champs.
Xplosion SC © 2013 Privacy Policy
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GU15 state cup champs.
click on the links to see more
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26 January In News – K1 Speed by marcus Tags: anaheim, Debut, Driven, inland empire, irvine, irwindale speedway, K1 Speed, los angeles, ontario, orange county, Race Weekends, Running, Speed Truck, super truck, torrance, Uli
K1 Speed Super Truck
K1 Speed Blog - go karts, karting and go-kart race events
K1 Speed will be sponsoring the #16 super truck, driven by our own Uli Perez for the 2008 season at Irwindale speedway. The K1 Speed truck will be running a few races throughout the year and will be displayed at our K1 Speed locations during off race weekends. The #16 super truck will make its first race debut on Saturday April 26th at Irwindale Speedway.


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Cloisters Restaurant at Bailbrook House Hotel is a fine dining restaurant that promises to be one of the most exciting additions to the Bath dining scene this year.
At a glance
- Fine dining restaurant
- Fresh, locally sourced ingredients
- Extensive wine list
- Perfect for a special occasion
Love it? Share it!
About Cloisters
Set in the original basement of Bailbrook Mansion House the restaurant design takes full advantage of the stunning architectural features of this historic building. The ceiling, made of painstakingly restored Bath Stone, is a set of round domes supported by pillars. Archways have been opened up to provide excellent views of the hotel grounds and the City of Bath in the valley beyond. There is a selection of seating areas to choose from including the logia setting with views of the lawn and the grand wisteria, two raised areas with views of the parkland and a further lower area for a more romantic setting. The lighting is a feature of the room and was sourced from Chad lighting of Birmingham and is modelled on a designed used in Warwick Castle. The restaurant is accessed by a lift down from the hotel lobby. The fine dining menu is supported where possible with ingredients from local suppliers.
Drinks may be enjoyed before and after dinner in one of the stylish lounges on the ground floor of Bailbrook Mansion House. These lounges benefit from unparalleled views over the Avon Valley and the City of Bath.
Opening times:
- Monday - Sunday dinner 7pm till 9.30pm
- Saturday & Sunday breakfast from 8am till 10:30am
- Sunday lunch from 12:30pm till 2pm
Our menu
Brixham Bay Scallops
Cornish Brown Crab & Watercress Risotto £14.00
Guinea Fowl & Foie Gras Terrine
Sherry Vinegar Jelly, Sauce Gribiche £10.00
Goat's Cheese Panna Cotta (V)
Tomato Consommé, Tomato Crostini & Fondue £10.00
Wild Somerset Rocket & Bath Blue Cheese Tart (V)
Toffee Apple & Thyme Purée £11.00
Broccoli & Baby Spinach Soup (V)
Cheese & Chive Scones £7.00
Seared Fillet of Halibut
Rainbow Chard, Tomato & Spring Onion Salsa £30.00
Assiette of Lighthorne Lamb
Slow Roasted Rump, Sweetbreads, Cured and Comfit Shoulder, Heritage Carrots, Lemon and Rosemary Jus £28.00
Slow Roasted Lackham Farm Duck
Braised Red Cabbage, Confit Potato Juniper & Vanilla Jus £27.00
Bromham Cauliflower & Sweet Potato Crumble (V)
Baby leaf spinach Purée, Pickled Cauliflower Sun Blush Tomato £22.00
Wild Mushroom, Spring Onion & Truffle Risotto (V)
Wild Rocket & Toasted Pumpkin Seeds £20.00
Banana & Tonka Bean Panna Cotta
Candied Cherries £9.00
Eton Mess
Meringue, Sweetened Cream, Strawberry Preserve Strawberry & Basil Sorbet, Somerset Strawberries £9.00
Caramel & Chocolate Fondant
Spiced Poached Pineapple £9.00
Orange & Grand Marnier Tart
Raspberry sorbet £9.00
Selection of Locally Produced Cheeses
Chutney, Grapes & Fruit Bread £14.00


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29 May, 2012@1:27 pm
12 comments
It's been five years since El-P's I'll Sleep When You're Dead, his last studio full-length for the currently dormant Definitive Jux imprint. Moving on to Fat Possum, the very prolific emcee/producer has made up for lost time by releasing two side-by-side albums – his own Cancer 4 Cure – and Killer Mike's R.A.P. Music, both of which he produced in full. Released within a week of one another, the two share similarities, but are different projects, end-to-end.
El takes to his own Cancer 4 Cure as a body of work, not something to be listened to on "shuffle". Each track blends into the next, and throughout the course of the album, El builds a solid groove from track-to-track. His production takes the forefront here, as this record is designed more like a rock album, as the tracks abandon the usual 16-bar-verse-then-hook rap song structure. As a matter fact, El boldly starts the album instrumentally on "Request Denied", not providing any lyrics until after the three minute mark. Clearly rooted in the drum programming styles of the 1980′s, El offers a glimpse of an alternate future where hip-hop production stayed pure and evolved naturally. Tracks like "True Story" or "Tougher Colder Killer" clearly borrow elements from hip-hop's golden era and builds atop them with android parts. If Killer Mike's R.A.P. Music was The Bomb Squad meets Ice Cube all over again, then this is Public Enemy meets Nine Inch Nails.
His lyrical content has always been designed in Ghostfacesque, wordy poetics, hardly ever breaking things down into simpler terms. At surface value, what we do get from El's rhymes are that he's sort of a disgruntled, robot war-fearing product of post 9/11 New York, as these reoccuring themes present themselves over and over on songs like the boom-bap heavy "Drones Over Bklyn" or the melodic "Works Every Time". The time to be taken to decipher each line is optional, but El's unique, angst-ridden delivery is better viewed as an instrument in itself. In other words, his voice completes the symphony.
If you've heard El's previous albums, you have an idea of what to expect here, and he certainly delivers on that promise. It's clear that El is hearing things the rest of us are not, as he has demonstrated in his multi-layered production both here and on Killer Mike's R.A.P. Music. In an age where people have forgotten how to make albums, whoring out their album tracklists to 50 different producers and guest artists, El has proven himself to be perhaps the most self-sufficient, endlessly consistent "producto" in hip-hop today.
I wanted to like it but don't. I played it twice. I can only take him lyrically for a few songs. This thing sucks a**. Rather its not for me.
While I appreciate the creativity, hard work and artistry on this LP it's just not the type of music I am into. I listened through it a couple of times and it's just not for me. Honestly I have tried to like El-P since Company Flow's Funcrusher cause so many people were hyped about them. His style is an acquired taste and not palatable for most people, including me. Again I respect what he does but I just can't listen to it. Killer Mike LP is off the hook though!
EL-P is the "Nine Inch Nails" of rap, always has been, you either like it or you hate it, there's no in between but he's always had a following and always will. Only reason I bring this up is because the album is EL-P's highest charting record to date as of today, so congrats to him, well earned, 15 years deep and still rising, not many artists can say that, in any genre
Long live the king!
next month in Bmore son.el-p killer mike mr. x & despot's flow is crank also
Way better than the Killer Mike album.I'm surprised it was rated lower than R.A.P. music.If I hear Mike say motherf****a one more time……!
Leave a Reply
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US transport companies cash in on Mexico trade boom
U.S. rail and trucking companies are making big investments on both sides of the border with Mexico to capitalize on booming trade between the two countries.Every day, about 10 Kansas City Southern trains crisscross the border at Laredo, Texas, hauling everything from cars to chemicals - up from about six trains just three years ago.
The fourth-largest U.S. publicly traded railroad is leading the charge to take advantage of the swelling freight traffic between the countries as manufacturing booms south of the border because of the rising costs of goods from China and other exporters.
Over the past five years, Kansas City Southern has spent about $300 million to lay roughly 90 miles of new track in Texas, buy and update terminals in Mexico and make other network upgrades. The railroad company now generates one-quarter of its revenue moving parts and finished goods across the border.
Union Pacific Corp, the No. 1 U.S. railroad company, owns a 26 percent stake in Mexican railway company Ferromex.
Like rivals CSX Corp and Norfolk Southern Corp , Union Pacific is partnering with Kansas City Southern to haul carloads in the United States to locations not served by the railroad.
As the U.S. economy creaks along, the growing business with Mexico is a cause for cheer: Both Kansas City Southern and Union Pacific are reporting much bigger increases in cross-border shipments than in overall volume.
Two areas that are "just exploding" are transporting automobiles into the United States and intermodal shipping - moving goods in containers that are shifted from truck to train or train to ship - said William Galligan, vice president of investor relations at Kansas City Southern.
The Kansas City, Missouri-based company, which took full ownership of a Mexican railroad now known as Kansas City Southern de Mexico in 2005, has built the first intermodal network between the countries.
Kansas City Southern, which started investing in the Mexican rail company a decade earlier, was betting the North American Free Trade Agreement would significantly alter shipping.
Total cross-border freight by train and truck has surged nearly 35 percent in the past five years, according to U.S. government data.
At $291 billion through September, the volume of goods crossing the border this year is set to top $352 billion in 2011 and $308 billion in 2010.
The Mexican automobile industry's double-digit production and export growth has boosted transportation needs.
Kansas City Southern expects Mexico's vehicle output to leap 30 percent to 40 percent by 2015, citing Wallenius Wilhelmsen Logistics data.
The company, which already serves nine auto plants in Mexico, said Honda Motor Co Ltd, Mazda Motor Corp , Nissan Motor Co Ltd and Audi AG will open plants there in the next two years. Five steel plants are also opening.
Galligan said Kansas City Southern was in talks with Asian and European manufacturers looking for space near the locations it serves in Mexico.
Coping with Drug War
Along with the boom in business come dangers. Companies with operations in Mexico must deal with the ongoing drug war. Kansas City Southern posts guards on trains in high-risk areas and scans cargo as trains cross the border.
But most of the problems are on the roads. The Mexican Council on Northeast Foreign Trade, a private trade association,
said 85 percent of illegal goods sent from Mexico to the United States were found in trucks.
A federal police officer who requested anonymity said it was a very big problem with life-and-death consequences. "Truckers in Tamaulipas state and Monterrey are often threatened with death if they don't transport what they're told to transport, drugs above all," the police official said.
Trains and trucks compete, but they have also partnered to keep up with demand.
"We don't have containers, we don't have intermodal customers. So we approached J.B. Hunt, Schneider and Swift Transportation, to name three big ones, and convinced them that this was a real huge opportunity,
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From Wikipedia, the free encyclopedia - View original article
|Systematic (IUPAC) name
|Clinical data
|Consumer Drug Information
|Licence data
|US FDA:link
|Pregnancy cat.
|Legal status
|Controlled (S8) (AU) Schedule I (CA) CD (UK) Schedule III (US)
|Dependence liability
|IV, IM, Insufflated, oral, topical
|Pharmacokinetic data
|Hepatic, primarily by CYP3A4[1]
|2.5–3 hours
|renal (>90%)
|CAS number
|ATC code
|Chemical data
|Mol. mass
|237.725 g/mol
|Physical data
|Melt. point
|(what is this?) (verify)
|Systematic (IUPAC) name
|Clinical data
|Consumer Drug Information
|Licence data
|US FDA:link
|Pregnancy cat.
|Legal status
|Controlled (S8) (AU) Schedule I (CA) CD (UK) Schedule III (US)
|Dependence liability
|IV, IM, Insufflated, oral, topical
|Pharmacokinetic data
|Hepatic, primarily by CYP3A4[1]
|2.5–3 hours
|renal (>90%)
|CAS number
|ATC code
|Chemical data
|Mol. mass
|237.725 g/mol
|Physical data
|Melt. point
|(what is this?) (verify)
Ketamine is a drug used in human and veterinary medicine, mainly for starting and maintaining general anesthesia. Other uses include sedation in intensive care, as a pain killer (particularly in emergency medicine and patients with potentially compromised respiration and/or allergies to opiate and barbiturate analgesics), and treatment of bronchospasm. This drug is sometimes used recreationally. Like other drugs in its class such as tiletamine and phencyclidine (PCP), ketamine is classified as a dissociative agent.[2] The state it induces is defined as "a trancelike cataleptic state characterized by profound analgesia and amnesia, with retention of protective airway reflexes, spontaneous respirations, and cardiopulmonary stability".[3] Studies have shown that respiratory function is unchanged with the administration of ketamine.[4] Though its impact on respiratory function is favorable, ketamine can still cause adverse effects which will be discussed below.
Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist but it acts at numerous other receptors (including opiate and sigma receptors) as well as indirect interactions with several neurotransmitters.[5] Nonetheless, NMDA antagonism is believed to be responsible for most of its therapeutic effects with other actions being generally related to side effects of the drug. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a health system.[6]
Uses as an anaesthetic:
In medical settings, ketamine is usually injected intravenously or intramuscularly.[7] Since it suppresses breathing much less than most other available anaesthetics,[8] ketamine is still used in human medicine as an anesthetic; however, due to the hallucinations it may cause, it is not typically used as a primary anesthetic, although it is the anaesthetic of choice when reliable ventilation equipment is not available.
Ketamine is frequently used in severely injured patients. It is the drug of choice for patients in traumatic shock who are at risk of hypotension.[9] Hypotension is extremely dangerous in patients with severe head injury[10] and ketamine is anaesthetic agent least likely to precipitate hypotension, often even able to prevent it.[11][12] For years medical myth has held that ketamine was dangerous in patients with head injury over concerns that it might transiently increase the pressure inside the skull. This small transient effect is completely outweighed by the devastation caused by hypotension in severely head injured patients. Air medical services and paramedics are using this drug with increasing frequency.[citation needed]
Ketamine tends to increase heart rate and blood pressure. Because it tends to increase or maintain cardiac output, it is sometimes used in anesthesia for emergency surgery when the patient's fluid volume status is unknown (e.g., from traffic accidents). Ketamine can be used in podiatry and other minor surgery, and occasionally for the treatment of migraine. Research is ongoing in France, the Netherlands, Russia, Australia and the US into the drug's usefulness in pain therapy, depression,[13] and for the treatment of alcoholism[14] and heroin addiction.[15]
It may also be used as an intravenous coanalgesic with opiates to manage otherwise intractable pain, particularly if this pain is neuropathic (pain due to vascular insufficiency or shingles are good examples). It has the added benefit of counteracting spinal sensitization or wind-up phenomena experienced with chronic pain. At these doses, the psychotropic side effects are less apparent and well managed with benzodiazepines.[16] Ketamine is a coanalgesic, so is most effective when used alongside a low-dose opioid; while it does have analgesic effects by itself, the higher doses required can cause disorienting side effects.[16] The combination of ketamine with an opioid may be useful for pain caused by cancer, as suggested in animal models.[17] A review article in 2013 concluded that "despite limitations in the breadth and depth of data available, there is evidence that ketamine may be a viable option for treatment-refractory cancer pain".[18]
The effect of ketamine on the respiratory and circulatory systems is different from that of other anesthetics. When used at anesthetic doses, it will usually stimulate rather than depress the circulatory system.[19] It is sometimes possible to perform ketamine anesthesia without protective measures to the airways. Ketamine is also a potent analgesic and can be used in subanesthetic doses to relieve acute pain; however, its psychotropic properties must be taken into account. Patients have reported vivid hallucinations, "going into other worlds" or "seeing God" while anesthetized, and these unwanted psychological side effects have reduced the use of ketamine in human medicine. They can, however, usually be avoided by concomitant application of a sedative such as a benzodiazepine.[16]
Low-dose ketamine is recognized for its potential effectiveness in the treatment of complex regional pain syndrome (CRPS).[20] Although low-dose ketamine therapy is established as a generally safe procedure, reported side effects in some patients have included hallucinations, dizziness, lightheadedness and nausea. Therefore, nurses administering ketamine to patients with CRPS should do so only in a setting where a trained physician is available if needed to assess potential adverse effects on patients.[21]
In some neurological intensive care units, ketamine has been used in cases of prolonged seizures. Some evidence indicates the NMDA-blocking effect of the drug protects neurons from glutamatergic damage during prolonged seizures.[22]
As part of a cream, gel, or liquid (only available from compounding pharmacies as it is not a branded product, specific formulation and ratios are specified by the prescribing physician) for topical application for nerve pain — the most common mixture is 10% ketoprofen, 5% lidocaine, and 10% ketamine.[citation needed] Other ingredients found useful by pain specialists and their patients, as well as the compounding pharmacists who make the topical mixtures, include amitriptyline, cyclobenzaprine, clonidine, tramadol, gabapentin, baclofen, and mepivacaine and other longer-acting local anaesthetics (e.g. tetracaine, procaine).
Ketamine is a "core" medicine in the World Health Organization's "Essential Drugs List", a list of minimum medical needs for a basic healthcare system.[23]
The dissociative anesthetic effects of ketamine have also been applied for postoperative pain management. Low doses of ketamine have been found to significantly reduce morphine consumption, as well as reports of nausea following abdominal surgery.[24]
Ketamine can be started using the oral route, or people may be changed from a subcutaneous infusion once pain is controlled. Bioavailability of oral ketamine hydrochloride is approximately 20%
Unlike the other well-known dissociatives PCP and DXM, ketamine is very short-acting. It takes effect within approximately 10 minutes,[26] while its hallucinatory effects last 60 minutes when insufflated or injected and up to two hours when ingested orally. The total experience lasts no more than a few hours.[27]
At subanesthetic doses, ketamine produces a dissociative state, characterised by a sense of detachment from one's physical body and the external world which is known as depersonalization and derealization.[28] At sufficiently high doses, users may experience what is called the "K-hole", a state of extreme dissociation with visual and auditory hallucinations.[29] John C. Lilly,[30] Marcia Moore[31] and D. M. Turner[32] (amongst others) have written extensively about their own entheogenic use of, and psychonautic experiences with ketamine. Both Moore and Turner died prematurely in a way that has been indirectly linked to the sedative properties of ketamine.[33]
These include:[34]
Emergence reactions manifest as vivid dreams, hallucinations, and delirium and occur in 12 percent of patients. These reactions are much less common in patients less than 15 years old and greater than 65 years old and when administered intramuscularly. Emergence reactions can occur up to 24 hours postoperatively. The chance of this occurring can be reduced by minimizing stimulation to the patient during recovery and pretreating with a benzodiazepine. If given a benzodiazepine, a lower dose of ketamine than normal should be given. Patients who experience severe reactions may require treatment with a small dose of a short or ultra-short acting barbiturate.[34]
Tonic-clonic movements are reported at higher anesthetic doses in greater than 10% of patients.[35]
As discussed below, current research suggests that acute ketamine exposure does not cause significant neurotoxicity.
Because ketamine is not administered chronically in a typical clinical setting, long-term effects are primarily reported and investigated in recreational ketamine users and in animal models.[36]
In 1989, psychiatry professor John Olney reported ketamine caused irreversible changes in two small areas of the rat brain, which, however, has significant differences in metabolism from the human brain, so may not occur in humans.[37][38][39][40] Indeed, a review published in 2009 found no evidence of ketamine-induced neuron death in humans.[41]
The first large-scale, longitudinal study of ketamine users found that current frequent ketamine users (at least 4 days/week, averaging 20 days/month) had increased depression and impaired memory by several measures, including verbal, short-term memory and visual memory. However, current infrequent (1–4 days/month, averaging 3.25 days/month) ketamine users and former ketamine users were not found to differ from controls in memory, attention and psychological well-being tests. This suggests the infrequent use of ketamine does not cause cognitive deficits, and that any deficits that might occur may be reversible when ketamine use is discontinued. However, abstinent, frequent, and infrequent users all scored higher than controls on a test of delusional symptoms.[42]
Short-term exposure of cultures of GABAergic neurons to ketamine at high concentrations led to a significant loss of differentiated cells in one study, and non-cell-death-inducing concentrations of ketamine (10 μg/ml) may still initiate long-term alterations of dendritic arbor in differentiated neurons. The same study also demonstrated chronic (>24 h) administration of ketamine at concentrations as low as 0.01 μg/ml can interfere with the maintenance of dendritic arbor architecture. These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal maintenance and development.[43][44]
More recent studies of ketamine-induced neurotoxicity have focused on primates in an attempt to use a more accurate model than rodents. One such study administered daily ketamine doses consistent with typical recreational doses (1 mg/kg IV) to adolescent cynomolgus monkeys for varying periods of time.[45] Decreased locomotor activity and indicators of increased cell death in the prefrontal cortex were detected in monkeys given daily injections for six months, but not those given daily injections for one month.[45] A study conducted on rhesus monkeys found that a 24-hour intravenous infusion of ketamine caused signs of brain damage in 5-day-old but not 35-day-old animals.[46] Some neonatal experts do not recommend the use of ketamine as an anesthetic agent in human neonates because of the potential adverse effects that it may have on the developing brain. These neurodegenerative changes in early development have been seen with other drugs that share the same mechanism of action of NMDA receptor antagonism as ketamine.[47]
The acute effects of ketamine cause cognitive impairment including reduced vigilance, verbal fluency, short-term memory, and executive function, as well as schizophrenia-like perceptual changes.[48]
According to a recent systematic review, 110 documented reports of irritative urinary tract symptoms from ketamine dependence exist.[49] Urinary tract symptoms have been collectively referred as "ketamine-induced ulcerative cystitis" or "ketamine-induced vesicopathy", and they include urge incontinence, decreased bladder compliance, decreased bladder volume, detrusor overactivity, and painful haematuria (blood in urine). Bilateral hydronephrosis and renal papillary necrosis have also been reported in some cases.[36][49] The pathogenesis of papillary necrosis has been investigated in mice, and mononuclear inflammatory infiltration in the renal papilla resulting from ketamine dependence has been suggested as a possible mechanism.[50]
The time of onset of lower urinary tract symptoms varies depending, in part, on the severity and chronicity of ketamine use; however, it is unclear whether the severity and chronicity of ketamine use corresponds linearly to the presentation of these symptoms. All reported cases where the user consumed greater than 5 grams per day reported symptoms of the lower urinary tract.[49] Urinary tract symptoms appear to be most common in daily ketamine abusers who have abused the drug for an extended period of time.[36] These symptoms have presented in only one case of medical use of ketamine. However, following dose reduction, the symptoms remitted.[36]
Management of these symptoms primarily involves ketamine cessation, for which compliance is low. Other treatments have been used, including antibiotics, NSAIDs, steroids, anticholinergics, and cystodistension.[49] Both hyaluronic acid instillation and combined pentosan polysulfate and ketamine cessation have been shown to provide relief in some patients, but in the latter case, it is unclear whether relief resulted from ketamine cessation, administration of pentosan polysulfate, or both. Further follow-up is required to fully assess the efficacy of these treatments.[49]
In case reports of three patients treated with (S)-(+)-ketamine for relief of chronic pain, liver enzyme abnormalities occurred following repeat treatment with ketamine infusions, with the liver enzyme values returning below the upper reference limit of normal range on cessation of the drug. The result suggests liver enzymes must be monitored during such treatment.[51]
Other drugs which increase blood pressure may interact with ketamine in having an additive effect on blood pressure including: stimulants, SNRI anti-depressants, MAOIs. Increase blood pressure, increased heart rate, palpitations and arrhythmias may be potential effects. Ketamine alone additionally increases intracranial pressure (ICP)
Ketamine may increase the effects of other sedatives, including but not limited to: alcohols,[52] benzodiazepines,[53] barbiturates,and opioids.[citation needed]
Ketamine is a noncompetitive NMDA receptor (NMDAR) antagonist. It appears to inhibit the receptor by binding both in the open channel and at an allosteric site.[54] The S(+) and R(-) stereoisomers bind with different affinities: Ki = 3200 and 1100 nM, respectively.[55] NMDAR antagonism results in analgesia by preventing central sensitization in dorsal horn neurons; in other words, ketamine's actions interfere with pain transmission in the spinal cord.[35] Ketamine also inhibits nitric oxide synthase, inhibiting production of nitric oxide, a neurotransmitter involved in pain perception, and hence further contributing to analgesia.[56] It also interacts with sigma and opioid receptors, but with lower affinity and without significantly contributing to analgesia.[57]
Ketamine also interacts with a host of other receptors to effect analgesia. It blocks voltage-sensitive calcium channels and depresses sodium channels, attenuating hyperalgesia; it alters cholinergic neurotransmission, which is implicated in pain mechanisms; and it acts as a noradrenaline and serotonin uptake inhibitor, which are involved in descending antinociceptive pathways.[35][58]
Ketamine affects catecholaminergic transmission as noted above, producing measurable changes in peripheral organ systems, including the cardiovascular, gastrointestinal, and respiratory systems:[56]
Ketamine is a chiral compound. Most pharmaceutical preparations of ketamine are racemic; however, some brands reportedly have (mostly undocumented) differences in their enantiomeric proportions. The more active enantiomer, (S)-ketamine, is also available for medical use under the brand name Ketanest S.[59]
Ketamine is absorbable via intravenous, intramuscular, oral, and topical routes due to both its water and lipid solubilities.[60] When administered orally, it undergoes first-pass metabolism, where it is biotransformed in the liver by CYP3A4 (major), CYP2B6 (minor), and CYP2C9 (minor) isoenzymes into norketamine (through N-demethylation) and finally dehydronorketamine.[61] Intermediate in the biotransformation of norketamine into dehydronorketamine is the hydroxylation of norketamine into 5-hydroxynorketamine by CYP2B6 and CYP2A6. Dehydronorketamine, followed by norketamine, is the most prevalent metabolite detected in urine.[62] As the major metabolite of ketamine, norketamine is one-third to one-fifth as potent anesthetically, and plasma levels of this metabolite are three times higher than ketamine following oral administration.[60][63] Bioavailability through the oral route reaches 17–20%; bioavailability through other routes are as follows: 93% intramuscularly, 25–50% intranasally, 30% sublingually, and 30% rectally.[35][61] Peak plasma concentrations are reached within a minute intravenously, 5–15 min intramuscularly, and 30 min orally.[63] Ketamine's duration of action in a clinical setting is 30 min to 2 h intramuscularly and 4–6 h orally.[35]
Plasma concentrations of ketamine are increased by diazepam and other CYP3A4 inhibitors.[35]
Pharmacologically, ketamine is classified as an NMDA receptor antagonist.[5] At high, fully anesthetic level doses, ketamine has also been found to bind to μ-opioid receptors type 2 in cultured human neuroblastoma cells – however, without agonist activity[64] – and to sigma receptors in rats.[65] Ketamine also interacts with muscarinic receptors, descending monoaminergic pain pathways and voltage-gated calcium channels,[66] and it inhibits hyperpolarization-activated cyclic nucleotide–modulated (HCN1) cation channels.[67]
Ketamine is synthesized from 2-chlorobenzonitrile, which reacts with the cyclopentylmagnesium bromide to give (2-chlorophenyl)(cyclopentyl)methanone. The next step is bromination using bromine to the corresponding bromoketone, which upon reaction with an aqueous solution of methylamine forms the methylimino derivative. During this reaction, a simultaneous hydrolysis of the tertiary bromine atom occurs. On heating the reaction product in decalin, a ring-expansion rearrangement occurs, forming ketamine.
Ketamine was first synthesized in 1962 by Calvin Stevens, a Parke Davis consultant conducting research on alpha-hydroxyimine rearrangements.[71] After promising preclinical research in animals, ketamine was introduced to testing in human prisoners in 1964.[71][72] These investigations demonstrated that ketamine's short duration of action and reduced behavioral toxicity made it a favorable choice over PCP as a dissociative anesthetic.[73] Following FDA approval in 1970, ketamine anesthesia was first given to American soldiers during the Vietnam War.[74]
Non-medical use of ketamine began on the West Coast of the United States in the early 1970s.[74] Early use was documented in underground literature such as The Fabulous Furry Freak Brothers. It was used in psychiatric and other academic research through the 1970s, culminating in 1978 with the publishing of psychonaut John Lilly's The Scientist, and Marcia Moore and Howard Alltounian's Journeys into the Bright World, which documented the unusual phenomenology of ketamine intoxication.[75] The incidence of non-medical ketamine use increased through the end of the century, especially in the context of raves and other parties.[76][77][78][79][80] However, its emergence as a club drug differs from other club drugs (e.g. MDMA) due to its anesthetic properties (e.g., slurred speech, immobilization) at higher doses;[80] in addition, reports of ketamine being sold as "ecstasy" are common.[81] The use of ketamine as part of a "post-clubbing experience" has also been documented.[82] Ketamine's rise in the dance culture was most rapid in Hong Kong by the end of the 1990s.[80] Before becoming a federally controlled substance in the United States in 1999, ketamine was available as diverted pharmaceutical preparations and as a pure powder sold in bulk quantities from domestic chemical supply companies.[71] Today much of the ketamine diverted for non-medical use originates in China and India.[71][72]
Related to its purported ability to cause confusion and amnesiac effects, ketamine can leave users vulnerable to drug-facilitated sexual assault.[83]
The increase in illicit use prompted ketamine's placement in Schedule III of the United States Controlled Substance Act in August 1999.[84]
In the United Kingdom, it became labeled a Class C drug on 1 January 2006.[62][85] On 10 December 2013 the UK ACMD recommended that the government reclassify ketamine to become a Class B drug,[86] and on 12 February 2014 the Home Office announced they would follow this advice "in light of the evidence of chronic harms associated with ketamine use, including chronic bladder and other urinary tract damage".[87][88]
The UK Minister of State for Crime Prevention, Norman Baker, responding to the ACMD's advice said that the issue of its recheduling for medical and veterinary would be addressed "separately to allow for a period of consultation."[87]
In Canada, ketamine is classified as a Schedule I narcotic, as of August 2005.[89] In Hong Kong, as of 2000, ketamine is regulated under Schedule 1 of Hong Kong Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals, for university research purposes, or with a physician's prescription.[90] By 2002, ketamine was classified as schedule III in Taiwan; given the recent rise in prevalence in East Asia, however, rescheduling into schedule I or II is being considered.[62]
In December 2013 the government of India added ketamine to Schedule X of the Drug and Cosmetics Act, adding restrictions on who can buy or sell it.[91]
Brand names for ketamine vary internationally:[92]
Some research in rodents has attributed the effects of ketamine to being an NMDA receptor antagonist,[54] which increases the activity of the AMPA receptor, and this boost in AMPA activity may be crucial for ketamine's rapid antidepressant actions.[93] NMDA and AMPA are receptors for the neurotransmitter glutamate. The glutamate system is an emerging target for antidepressant drug discovery and development.[94][95][96]
Acute administration of ketamine at the higher dose, but not imipramine, increased BDNF protein levels in the rat hippocampus. The increase of hippocampal BDNF protein levels induced by ketamine might also be necessary to produce a rapid onset of antidepressant action in rats.[97]
Research on the antidepressant effects of ketamine infusions at subanaesthetic doses has consistently shown rapid (4 to 72 hours) responses from single doses, with substantial improvement in mood in the majority of patients and remission in some. However, these effects are often short-lived, and attempts to prolong the antidepressant effect with repeated doses and extended ("maintenance") treatment have resulted in only modest success.[98]
When treating patients suffering from complex regional pain syndrome (CRPS) with a low-dose (subanesthetic) ketamine infusion, some patients were observed in the early 2000s to make a significant recovery from depression. This recovery was not formally documented, as the primary concern was pain management and it was not possible to quantify to what degree depression recovery was secondary to the patient's recovery from CRPS.[99] This led the investigators to conduct a study in two patients with severe depression, with the dose carefully monitored to prevent hallucinogenic side effects. The patients demonstrated significant, long-term improvement.[99]
A randomized placebo-controlled study in 18 patients conducted at the US NIH and published in 2006, found ketamine significantly improved treatment-resistant major depression within hours of injection that lasted up to one week after the single dose.[100] NIMH director Dr. Thomas Insel remarked:"To my knowledge, this is the first report of any medication or other treatment that results in such a pronounced, rapid, prolonged response with a single dose. These were very treatment-resistant patients."[101]
A 2013 two-site randomized controlled clinical trial of ketamine in patients with treatment-resistant depression found that 64% of the patients responded after 24 hours according to the Montgomery–Åsberg Depression Rating Scale compared to 28% responding to midazolam.[102] A 2014 study found that a series of three or six ketamine infusions had a rapid antidepressant effect in treatment-resistant depression (TRD). 29% of a small sample responded, in a period ranging from six hours to the third infusion; beneficial effects lasted from 25 to 168 days. Some test subjects suffered acute adverse reactions during the infusion (7%) or failure to benefit and increasing anxiety (18%). Ketamine was not associated with memory impairment.[103]
Kudoh et al. investigated whether ketamine is suitable for depressed patients who had undergone orthopedic surgery.[104] Depressed mood, suicidal tendencies, somatic anxiety, and hypochondriasis significantly decreased in the active group as compared with the control. The group receiving ketamine also had significantly lower postoperative pain.
The Russian doctor Evgeny Krupitsky has claimed to have encouraging results by using ketamine as part of a treatment for alcohol addiction which combines psychedelic and aversive techniques.[105][106] This method involved psychotherapy, controlled ketamine use, and group therapy, and resulted in 60 of the 86 alcoholic males selected for the study remaining fully abstinent through one year of treatment. For heroin addiction, the same researcher reached the conclusion that one ketamine-assisted psychotherapy session was significantly more effective than active placebo in promoting abstinence from heroin during one year without any adverse reactions. In a recently published study, 59 detoxified inpatients with heroin dependence received a ketamine-assisted psychotherapy (KPT) session prior to their discharge from an addiction treatment hospital, and were then randomized into two treatment groups.[citation needed]
Participants in the first group received two addiction counseling sessions followed by two KPT sessions (with a single IM injection of 2 mg/kg ketamine), with sessions scheduled on a monthly interval (multiple KPT group). Participants in the second group received two addiction counseling sessions on a monthly interval, but no additional ketamine therapy sessions (single KPT group). At one-year follow-up, survival analysis demonstrated a significantly higher rate of abstinence in the multiple KPT group. Thirteen of 26 subjects (50%) in the multiple KPT group remained abstinent, compared to 6 of 27 subjects (22.2%) in the single KPT group (p < 0.05). No differences between groups were found in depression, anxiety, craving for heroin, or their understanding of the meaning of their lives. Three sessions of ketamine-assisted psychotherapy were found to be more effective than a single session for the treatment of heroin addiction.[107][108]
Krupitsky and Kolp summarized their work to date in 2007.[109]
Ketamine is being used as an experimental and controversial treatment for complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD). CRPS/RSD is a severe chronic pain condition characterized by sensory, autonomic, motor, and dystrophic signs and symptoms. The pain in CRPS is continuous, worsens over time, and is usually disproportionate to the severity and duration of the inciting event. The hypothesis is that ketamine manipulates NMDA receptors which might reboot aberrant brain activity. One treatment modality is a low-dose ketamine infusion of between 25 and 90 mg per day, over five days, either in hospital or as an outpatient, called the awake technique. Open label, prospective, pain journal evaluation of a 10-day infusion of intravenous ketamine (awake technique) in the CRPS patient concluded, "A four-hour ketamine infusion escalated from 40–80 mg over a 10-day period can result in a significant reduction of pain with increased mobility and a tendency to decreased autonomic dysregulation".[110]
Case notes of 33 patients whose CRPS pain was treated by the inpatient administration of a continuous subanesthetic intravenous infusion of ketamine were reviewed at Mackay Base Hospital, Queensland, Australia. A total of 33 patients with diagnoses of CRPS who had undergone ketamine treatment at least once were identified. Due to relapse, 12 of 33 patients received a second course of therapy, and two of 33 patients received a third. There was complete pain relief in 25 (76%), partial relief in six (18%), and no relief in two (6%) patients.
The degree of relief obtained following repeat therapy (N=12) appeared even better, as all 12 patients who received second courses of treatment experienced complete relief of their CRPS pain. The duration of relief was also impressive, as was the difference between the duration of relief obtained after the first and after the second courses of therapy. In this respect, following the first course of therapy, 54% of 33 individuals remained pain-free for three months or more and 31% remained pain free for six months or more. After the second infusion, 58% of 12 patients experienced relief for a year or more, while almost 33% remained pain free for over three years. The most frequent side effect observed in patients receiving this treatment was a feeling of inebriation. Hallucinations occurred in six patients. Less-frequent side effects also included complaints of light-headedness, dizziness, and nausea. In four patients, an alteration in hepatic enzyme profile was noted; the infusion was terminated and the abnormality resolved thereafter. No long-term side effects were noted.[110] This procedure has only recently been allowed in the United States for the treatment of CRPS.
A second treatment modality consists of putting the patient into a medically induced coma and giving an extremely high dosage of ketamine, typically between 600 and 900 mg.[111] This version, previously done in Germany and Mexico, is now currently only preformed in the United States.[112] According to Dr Schwartzman, 14 of 41 patients in the coma-induced ketamine experiments were completely cured. "We haven't cured the original injury", he says, "but we have cured the RSD or kept it in remission. The RSD pain is gone." He added, "No one ever cured it before... In 40 years, I have never seen anything like it. These are people who were disabled and in horrible pain. Most were completely incapacitated. They go back to work, back to school, and are doing everything they used to do. Most are on no medications at all. I have taken morphine pumps out of people. You turn off the pain and reset the whole system."[111]
In Tuebingen, Germany, Dr Kiefer treated a patient who presented with a rapidly progressing contiguous spread of CRPS from a severe ligamentous wrist injury. Standard pharmacological and interventional therapy successively failed to halt the spread of CRPS from the wrist to the entire right arm. Her pain was unmanageable with all standard therapies. As a last treatment option, the patient was transferred to the intensive care unit and treated on a compassionate care basis with anesthetic doses of ketamine in gradually increasing (3–5 mg/kg·h) doses in conjunction with midazolam over a period of five days. On the second day, edema and discoloration began to resolve and increased spontaneous movement was noted. On day six, symptoms completely resolved and infusions were tapered. The patient emerged from anesthesia completely free of pain and associated CRPS signs and symptoms. The patient has maintained this complete remission from CRPS for eight years now. The psychiatric side effects of ketamine were successfully managed with the concomitant use of midazolam and resolved within a month of treatment.[113]
According to a recent report on NPR,[114] Demitri Papolos uses ketamine to treat children with "fear of harm" profile, a condition characterized by: sleep disturbances including frequent and terrifying nightmares; an extreme reaction when anyone tries to control their behavior; and overheating, especially at night. Although "fear of harm" profile has been lumped in with bipolar disorder over the recent decades that understanding is emerging about these concerns, "fear of harm" may be related to an overly-sensitive "flight-or-fight" reaction, which classical bipolar disorder is not.
In veterinary anesthesia, ketamine is often used for its anesthetic and analgesic effects on cats, dogs, rabbits, rats, and other small animals. It is an important part of the "rodent cocktail" a mixture of drugs used for anesthetizing rodents.[citation needed] Veterinarians often use ketamine with sedative drugs to produce balanced anesthesia and analgesia, and as a constant-rate infusion to help prevent pain wind-up. Ketamine is used to manage pain among large animals, though it has less effect on bovines.[citation needed] It is the primary intravenous anesthetic agent used in equine surgery, often in conjunction with detomidine and thiopental, or sometimes guaifenesin.
Ketamine was referenced in several episodes of the television show House. It was first mentioned in the finale of the second season, "No Reason",[115] and was responsible for temporarily relieving House's leg pain.[116]
emcdda was invoked but never defined (see the help page).
|Wikimedia Commons has media related to Ketamine.


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'NBA Rush' pits real NBA players against an alien invasion. Where on earth (or beyond) did this game come from?
Game List
Best New Tablet Games: the Duke returns, Joe gets dangerous, and a double dose of Windows games
Hello Games is releasing 'Joe Danger Infinity' this week despite being ravaged by a flood
Watch the fluid ninja action of 'Shadow Blade' in this gameplay footage
'Rayman Jungle Run' goes free on iOS as some players report erased saves
Game Guide
The 25 Best Windows Games for Tablets


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Google Ads Manager – Easier Way To Handle Web Ads
Official Google Blog recently announced a new service – Google Ads Manager. In a nutshell, it is a control center for all the ads have in your website, or blog. If you need to edit the HTML, templates or blog widgets to get a new ads reflected on the website, this is definitely what you are looking for. It helps you to manage all ads in one central place. Also with Google AdSense the biggest player in the ad network industry, it's pretty convincing that publishers will want a Google Ads Manager account.
Google Ads Manager is currently on invitation only, why not request for an invitation? I've submitted mine.
Author: Alfredo K
Alfredo K is Hongkiat.com's editor. He believes in working hard, and playing hard and hopes to one day publish his own travel guide for the food lover.