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Rx drug information, pharmaceutical research, clinical trials, news, and more
AFINITOR (everolimus), an inhibitor of mTOR, is an antineoplastic agent.
AFINITOR® is indicated for the treatment of patients with advanced renal cell carcinoma after failure of treatment with sunitinib or sorafenib.
FDA OKs New Kids' Dose of Cancer Drug Source: MedPage Today Product Alert [2012.08.30]WASHINGTON -- The FDA has approved a pediatric dosage of the cancer drug everolimus (Afinitor Disperz) for the treatment of a rare brain tumor.
Unsuspected mutations caused patient's dramatic response and resistance to cancer drug Source: Endocrinology News From Medical News Today [2014.10.10]The DNA of a woman whose lethal thyroid cancer unexpectedly "melted away" for 18 months has revealed new mechanisms of cancer response and resistance to the drug everolimus, said researchers from...
Efficacy and safety of everolimus for subependymal giant cell astrocytomas
associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised,
placebo-controlled phase 3 trial. [2013]subependymal giant cell astrocytomas associated with tuberous sclerosis complex... INTERPRETATION: These results support the use of everolimus for subependymal
Everolimus for advanced pancreatic neuroendocrine tumours: a subgroup analysis
evaluating Japanese patients in the RADIANT-3 trial. [2012]enrolled in the RADIANT-3 study... CONCLUSIONS: These results support the use of everolimus as a valuable treatment
Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib. [2011.12]A 70-year-old man with metastatic renal cell carcinoma developed progressive liver metastases after 8 weeks of treatment with the multitargeted tyrosine kinase inhibitor (TKI) sunitinib... This case illustrates the potential for patients with metastatic renal cell carcinoma, a malignancy with historically poor prognosis, to derive long-term benefit from everolimus when used in a manner consistent with its approved indication (after TKI therapy with sunitinib or sorafenib).
Impact of Lesion Length and Vessel Size on Clinical Outcomes After Percutaneous Coronary Intervention With Everolimus- Versus Paclitaxel-Eluting Stents Pooled Analysis From the SPIRIT (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System) and COMPARE (Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice) Randomized Trials. [2011.11]OBJECTIVES: The aim of this study was to investigate the impact of reference vessel diameter (RVD) and lesion length (LL) on the relative safety and efficacy of everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES). BACKGROUND: Lesion length and RVD are well-known predictors of adverse events after percutaneous coronary intervention... CONCLUSIONS: Patients with short lesions in large vessels have low rates of MACE at 2 years after treatment with either EES or PES. In higher-risk patients with long lesions and/or small vessels, EES results in significant improvements in both clinical safety and efficacy outcomes. (A Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Patients With de Novo Native Coronary Artery Lesions; NCT00180310; SPIRIT III: A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With de Novo Native Coronary Artery Lesions; NCT00180479; SPIRIT IV Clinical Trial: Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Subjects With de Novo Native Coronary Artery Lesions; NCT00307047; A Randomized Controlled Trial of Everolimus-eluting Stents and Paclitaxel-eluting Stents for Coronary Revascularization in Daily Practice: The COMPARE Trial; NCT01016041). Copyright (c) 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Biodegradable polymer versus permanent polymer drug-eluting stents and everolimus- versus sirolimus-eluting stents in patients with coronary artery disease: 3-year outcomes from a randomized clinical trial. [2011.09.20]OBJECTIVES: The aim of this study was to compare the 3-year efficacy and safety of biodegradable polymer with permanent polymer stents and of everolimus-eluting stents (EES) with sirolimus-eluting stents (SES). BACKGROUND: Biodegradable polymer drug-eluting stents (DES) offer potential for enhanced late outcomes in comparison with permanent polymer stents. In addition, there is increasing interest in the comparison of EES (Xience, Abbott Vascular, Abbott Park, Illinois) versus SES (Cypher, Cordis Corporation, Miami Lakes, Florida)... CONCLUSIONS: Biodegradable polymer and permanent polymer DES are associated with similar clinical outcomes at 3 years. In addition, EES are comparable to SES in terms of overall clinical efficacy and safety. (Intracoronary Stenting and Angiographic Results: Test Efficacy of 3 Limus-Eluting STents [ISAR-TEST 4]: Prospective, Randomized Trial of 3-limus Agent-eluting Stents With Different Polymer Coatings; NCT00598676). Copyright (c) 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Everolimus (RAD001) in Metastatic Transitional Cell Carcinoma of the Urothelium [Recruiting]
The purpose of this study is to learn what effects, good and/or bad, Everolimus has on
advanced urothelial cancer.
The goal of this clinical research study is to learn if the study drug Everolimus can shrink
or slow the growth of urothelial cancer. The safety of this drug will also be studied. The
patients physical state, changes in the size of the tumor, and laboratory findings taken
while on-study will help us decide if Everolimus is safe and effective.
RAD001 (Everolimus) + Docetaxel + Cisplatin as Induction Chemotherapy in Patients With Local-Regional Advanced Head and Neck Cancer [Recruiting]
The purpose of this study is to test the safety of RAD001 (everolimus) tablets at different
dose levels, when added to docetaxel and cisplatin. We want to find out what effects, good
and/or bad, that everolimus has when added to docetaxel and cisplatin as treatment for head
and neck cancer.
Everolimus (RAD001) in Primary Therapy of Waldenstrom's Macroglobulinemia [Recruiting]
The purpose of this research study is to determine the safety of RAD001(Everolimus) and the
highest dose of this drug that can be given to people safely. RAD001(Everolimus) is a drug
that works by preventing cells in the body from growing and dividing. Information from basic
and Phase I clinical research studies suggests that RAD001 also may help to prevent tumor
growth in people with relapsed or refractory lymphoma.
Radiation Therapy (IMRT) + RAD001 (Everolimus) + Cisplatin for Patients With Head and Neck Cancer [Recruiting]
The purpose of this study is to determine the best doses of RAD001 (everolimus) tablets and
cisplatin to give to patients who are receiving radiation therapy for head and neck cancer.
Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict Sensitivity [Recruiting]
For patients with malignant pleural mesothelioma that has grown despite treatment with
standard chemotherapy, no treatment has yet proven beneficial. The purpose of this study is
to find out what effects, both good and bad, that everolimus has on the cancer. Everolimus
works by blocking a protein that helps the cancer grow. The goal of this clinical research
study is to learn if the study drug everolimus can shrink or slow the growth of
mesothelioma. The safety of this drug will also be studied. The patients' physical state,
changes in the size of the tumor, and laboratory findings taken during the study will help
us decide if everolimus is safe and effective.
Neoplasm Malignant (362),
Neoplasm Progression (337),
Death (296),
Fatigue (196),
Dyspnoea (190),
Pyrexia (173),
Diarrhoea (150),
Cough (123),
Pneumonia (119),
Anaemia (113), more >>
All Rights reserved - Copyright DrugLib.com, 2006-2014


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For the first time some indians have arranged recitation of !sampurna ram charitra manas! in 24 hours with the cooperations of indians of seven countries starting from dulles(usa)) on 23rd may, then california, fizi,australia,singapore, varanasi,delhi ad mumbai (india)maritus, nigeria, london and back to dallas through video conferencing?is it not a unique attempt and first of its kind?how do you like it?
Asked by Ramesh Agarwal, 23 May '09 08:35 pm
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Answers (4)
Yes it is a great thing to have happened, which I didnot think can happen even in dreams. Thanks for the information.Answered by rajnikant raiyarela, 23 May '09 08:52 pm
Make no diff to me. let them do what they like to do. you tell me how does it touvh my life or life of any other indian ??????Answered by iqbal seth, 23 May '09 08:42 pm
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What purpose does it serve? Does it help anybody\'s spiritual journey? wasting resources ! Thats my view !Answered by Shunmugham, 24 May '09 10:30 am
This is gr8 news for ram bhaktasAnswered by Dinesh C S, 23 May '09 08:52 pm

subset: commoncrawl


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Alex Yancher, one of the Pantry founders, has a post on Food+Tech Connect about innovation in the food space. It's a great read and further evidence that the hardware renaissance extends past PCBs and devices to impact huge markets like food preparation and delivery.
The first funding announcement was from Airware. They raised a $25 million Series B from Kleiner Perkins. Over the past two years venture and overall interest in drones has increased a staggering amount. Jonathan Downey, CEO of Airware, has assembled the best team in the world for drones and is designing the core platform that will power the coming drone revolution. Watching the drone business mature around Airware and others is and will be a fascinating voyage, but we and others strongly believe Airware will be a hub in that revolution.
The second funding announcement was Spire, formerly Nanosatisfi, who raised a $25 million Series A led by RRE. Peter Platzer and team left Lemnos Labs in early 2013 after raising a seed round and since then have launched four cubesats into orbit. They have redefined the cost structure for acquiring novel, global, proprietary data. We can't wait to see what their customers do with the information coming from the dozens of cubesats to be launched in the coming year. The Spire team's success is especially poignant for us as they were one of the first companies to graduate from Lemnos, and they influenced our program as much as we hopefully influenced them.
Airware and Spire are proving aerospace companies can be created for a fraction of the time and cost it took existing market players, creating tremendous opportunities and customer value. They do this by focusing on a Minimum Flyable Product (h/t to Amir Hirsch, CEO of Flying Selfie). Spire built and launched their first two cubesats 15 months after the company was founded for less than $1M. To put this in perspective, the F-35 program is approaching its its 20th anniversary ($10's of billions of dollars later) and the first operational unit isn't expected until December of next year!
We're looking forward to continued disruption in the aerospace market, from drones to near space. We expect to make another half dozen investments in these sectors in the coming years, starting with strong entrepreneurs like Peter and Jonathan and their bold plans. If you are an engineer interested in joining the aerospace revolution, check out our portfolio companies' job listings or send an email with your qualifications to firstname.lastname@example.com]]>
Today's guest is Adam Ellsworth, the founder of 8-Bit Lit and leader in the hardware entrepreneur community.
If you have questions or comments about this podcast, send email to firstname.lastname@example.com.
Eric Klein – Twitter : @lemnoslabs, email : firstname.lastname@example.com
Adam Ellsworth – Twitter : @azellsworth, email : email@example.com
To subscribe to this podcast in iTunes, click here]]>
Episode 7′s guest is Dave Merrill, co-founder of Sifteo, creators of the award-winning interactive game system.
If you have questions or comments about this podcast, send email to firstname.lastname@example.com.
Eric Klein – Twitter : @lemnoslabs, email : firstname.lastname@example.com
Dave Merrill – Twitter : @merrill, email : firstname.lastname@example.com
To subscribe to this podcast in iTunes, click here]]>
DO your research. Use tools like Angellist and Crunchbase to identify investors by stage and market. Read bios and click through portfolios.
DON'T cold email. Warm intros from portfolio CEOs are best, but if you are new to the startup landscape, search your personal network for industry, academic or peer connections. Intros from other investors work too, but make sure they are putting their money where their mouth is.
DO personalize your email. Explain why you think the investor is a good fit for your startup. Mention common interests, maybe you are alumni of the same university.
DON'T send mass emails. I wish I didn't have to list this, but at least once a year I get a mass email that was obviously sent to hundreds of investors. Don't be that asshole.
DO include information about your startup. At minimum include a brief paragraph about your team, product, market and traction to date. It's better to attach a deck.
DON'T argue if the intro was declined. Perhaps there is a portfolio conflict or it's just not a good fit. This is why it's a good idea to do your research first.
DO propose specific dates & times for an initial phone call or meeting. We're all busy people and we don't need to exchange 4 emails to schedule something when 1 would suffice.
DON'T be rude to associates. Many associates are part of the investment team and they can be your biggest advocates. Plus, you'll want them on your side because they will probably be making most of the reference calls.
DO keep track. Share a google spreadsheet with your co-founders and advisors. Monitor the progress of your raise, how many intros are converting to meetings, how many meetings are converting into commitments, etc.
DON'T be afraid to follow up. I like to include a column for last contact and next steps. If you were expecting feedback and didn't receive any, it may be helpful to shoot over a friendly reminder email after a week or two. If after three weeks you haven't heard anything, well, they are probably not interested.
DO update folks on your progress. Every raise has a "tipping" point, maybe it's a commitment from a prominent investor or crossing the 50% mark. Investors can be uncomfortable taking funding risk and all it takes is a demonstration of momentum to give them confident that you are going to cross the finish line.
Episode 6′s guest is John Stanfield, founder and CEO of Local Motion, who is developing car-sharing technologies for fleets.
If you have questions or comments about this podcast, send email to email@example.com.
Eric Klein – Twitter : @lemnoslabs, email : firstname.lastname@example.com
John Stanfield – Twitter : @getlocalmotion, email : email@example.com
To subscribe to this podcast in iTunes, click here]]>
I'm trying to hear my co-founder, Scott, walk me through our detailed product development roadmap but it is hard not be distracted: in the background someone is flying a mini drone in the middle of the Lemnos warehouse, across the room a team is assembling dozens of units for field testing, a neighboring team fills a whiteboard with complex equations. Welcome to Lemnos Labs – the home of 6SensorLabs for the last 6 months, which have flown by faster than any drone I've seen.
What happens at Lemnos? You get inspired. You get real. You get it done.
You get inspired. We walked through the doors of Lemnos with an idea to enable people to trust their food by developing a portable food sensor, starting with the rapid detection of gluten to support the estimated 30 million people in the US with gluten intolerance. We had a proof of concept that worked – you could take a piece of food and place it in a disposable capsule to see if gluten was present. We were inspired to do something big but Lemnos inspired us to go huge. And we see the path to huge by visiting Lemnos companies like Airware, Nanosatisfi, Momentum and Sproutling who have graduated from the nurturing confines of Lemnos to founding new offices, growing teams and building products that will change our world.
I am inspired by the stream of experience that pours through Lemnos in the form of mentors, who have spent hours with me discussing topics ranging from marketing strategy to manufacturing. The person providing my team advice on marketing strategy ran one of the most prolific brands in American kitchens: Pillsbury. That's one small example of dozens of similar encounters. We are soaking it up like a gluten-free sponge cake.
You get real. When you start something that doesn't exist life's normal highs and lows are amplified. The delta between the extreme high and extreme low can feel like a terrifying free fall towards rock bottom or a rocket ship launch towards glory, depending on the swing of the week/day/hour. The importance of picking the right co-founder to survive those swings is key – I'm so thankful for Scott. I also have the Lemnos family. I have regular meet-ups with an amazing and experienced CEO of another portfolio company, and it's an opportunity to be frank and ask for advice from someone who has gone through this before and who is completely kicking ass.
Once a month the CEOs of Lemnos companies gather to share what's working, what's challenging and how we can help each other. Insights from these meetings have significantly changed how I approach 6Sensor's culture, hiring strategy and fundraising strategy. These gatherings also illuminate the simple fact that everyone goes through a free fall from time to time – that's just real.
You get it done. A day at Lemnos feels like a week. In the last 6 months at Lemnos, we have done lots of planning and developing: gathered primary consumer feedback on preliminary product designs, published a robust product requirements document shared with our development partners, crafted the beginning of a brand identity, developed sensing technology that is 10X faster than existing methods for gluten detection, raised seed funding and doubled our team. With the infrastructure in place, we are pushing to build the next iteration of our product by June of this year. When the team needs a little boost of inspiration we simply absorb the current scene of the warehouse. When we need an extra boost of inspiration, we turn to Revolve Robotics and Bia, watching the teams ship hundreds of product a week to customers. We get inspired, we get real and we get it done.
Shireen Yates
CEO, 6SensorLabs
Episode 5′s guest is Cheryl Kellond, founder and CEO of Bia, who is creating an iconic sports brand for women. Their first product is the Bia Sport watch.
If you have questions or comments about this podcast, send email to email@example.com.
Eric Klein – Twitter : @lemnoslabs, email : email@example.com
Cheryl Kellond – Twitter : @XXfounder, email : email@example.com
To subscribe to this podcast in iTunes, click here]]>
It is really our founders that deserve thanks. It was because of their big ideas that we were able to raise our new fund, largely by the success they have achieved to date. It's still early for metrics, but our first portfolio has raised over $35M as a group (including three A rounds) and we expect this number to double by the summer.
The way that we invest is still the same ($100k for 10% is typical), but we're now able to tackle more ambitious hardware ideas with a larger initial check ($250k) and reserve capital for later rounds. What we've found is that some companies, especially high tech ones, may need more money to hit their first milestone.
Our focus will continue to be on quality over quantity. We make sure that we have enough partner bandwidth (and enough space in the warehouse) to ensure success at the earliest stage of hardware. To this end we will invest in 8-12 companies a year and spend 6-15 months with them. Our definition of hardware remains broad — anything that involves moving atoms or electrons — but we're specifically focused on aerospace, robotics, transportation, agriculture and IoT (both consumer and B2B).
Although it's exciting to see the huge uptick of hardware startups, it's still not for the faint of heart. It still takes an experienced multi-disciplinary team with knowledge of mechanical engineering, electrical engineering, firmware, software, manufacturing, logistics, marketing, fundraising…and that's just the tip of the iceberg. But we're here to make it a little less hard.]]>
We're looking for someone who has a diligent work ethic, excellent critical thinking skills, and the burning desire to help startups create world-changing hardware. Lemnos Labs is the early stage hardware fund bringing Silicon back to the Valley, and you'll be at ground zero of the renaissance.
· Marketing and Outreach
Our warehouse is a hub in the San Francisco hardware startup scene. Whether it's a meet-up group needing space, a Lemnos conference deep-diving into technology, or a co-sponsored event with our strategic and venture partners, you'll be integral in organizing and executing these soirees. You'll get to know everyone working on hardware startups, giving you insights and connections few others have.
We maintain an active presence on the inter-webs, and we're looking for someone who enjoys connecting with our followers via email, Twitter, Facebook, AngelList, podcasts, etc. You'll be part of our digital voice.
· Office Manager
Making sure our office, the Forge, is in top form for our startups, visitors, and partners is a critical part of this role. The startups themselves help keep the Forge in good condition, but you are ultimately responsible for the quality of our working environment.
· Partner Assistance
The three Lemnos Labs partners are fairly self-sufficient, but we could definitely use help with scheduling meetings, filtering common digital inboxes, ordering items, and greeting our guests. You'll also assist with our mentor program.
· Special Projects
While our utility player has plenty of important tasks, we know this person is motivated and ready to learn. As you ramp up, there will be opportunities to execute research under partner tutelage, be the representative for Lemnos at industry events, and other top secret things.
Our ideal candidate is well-educated, motivated to learn, and has a infectious positive attitude. We're ideally looking for a college graduate with a degree in marketing or engineering who wants to learn the inner workings of an early stage hardware fund. You have excellent communication skills, both written and verbal. A demonstrated ability to organize great events is a big plus.
This full time role is open today and based at our office in San Francisco's Dogpatch neighborhood. Lemnos Labs has a market competitive compensation package including benefits. If you are interested in applying, please send your resume and cover letter to email@example.com.]]>


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Table 3
Repeated measures analysis of carotid plaque score
Data are mean (SD) unless otherwise stated. Analyses are for modified intention-to-treat analyses of participants with at least one measurement after baseline; baseline data missing for one patient in placebo group, therefore not analysed. Figure 1 shows number of patients attending the relevant visits.
* Adjusted for age, sex, smoking status, systolic and diastolic blood pressure, HDL-cholesterol, LDL-cholesterol, and estimated glomerular filtration rate.
† Sensitivity analysis.


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Press Release #188 (5/23/14)
Movies On Demand on Cable Schedule Update – June 2014
As we are all revving up for summer, Movies On Demand on cable is revving up your viewing enjoyment with five top action movies, all making their television premieres this month.
Lone Survivor, starring Mark Wahlberg as a Navy SEAL ambushed in Afghanistan, is based on a New York Times bestseller and directed by Peter Berg (Friday Night Lights). The next chapter in an epic saga is 300: Rise of an Empire, based on Xerxes, a graphic novel from author Frank Miller about an ancient battle between Greece and Persia.
Liam Neeson and Julianne Moore star in Non-Stop, a suspense thriller aboard a transatlantic flight in which a U.S. Air Marshall (Neeson) receives threatening texts that passengers will be killed every 20 minutes unless a huge cash deposit is made in an off-shore account. In this reboot of the sci-fi classic, RoboCop pits a part-man, part-robot police officer against the corporation that created him with profits in mind. Finally, Director Kenneth Branagh brings us Jack Ryan: Shadow Recruit with Chris Pineplaying a CIA analyst turned spy in this post-9/11 terrorism spy thriller, also with Kevin Costner.
For action of a completely different kind, for the kids and all those who are young at heart, MOD premieres The LEGO Movie, a huge hit at the box office, and adored by fans and critics alike (96% positive reviews on Rotten Tomatoes).
Cable is the nation's powerhouse in delivery of movies via the On Demand platform, representing about half of all paid movie rentals in the U.S., far outpacing satellite, iTunes, Amazon and all others.* When combined, cable, telco and satellite represent 84% of the market share, while only 16% of movie orders come from digital storefronts. Movies On Demand on Cable (MOD) is the easiest, most convenient way to rent movies from home instantly, with just a click of the remote. Most titles are in HD, and in 3D where indicated. It is part of digital cable service.
June 2014 Movies On Demand on Cable Major Studio Television Premieres**
Lone Survivor – Premieres 6/3, (same day as DVD, weeks before Netflix & Redbox), R, Action, Mark Wahlberg, Taylor Kitsch
RoboCop – Premieres 6/3, (same day as DVD), PG-13, Action, Joel Kinnaman, Gary Oldman
Jack Ryan: Shadow Recruit – Premieres 6/10, (same day as DVD), PG-13, Action, Chris Pine, Keira Knightley
Non-Stop – Premieres 6/10, (same day as DVD, weeks before Netflix & Redbox), PG-13, Thriller, Liam Neeson, Julianne Moore
The LEGO Movie – Premieres 6/17, (same day as DVD, weeks before Netflix & Redbox, available in 3D), PG, Animated, voices: Chris Pratt, Will Ferrell
Son of God – Premieres 6/17, (weeks before Netflix & Redbox), PG-13, Drama, Diogo Morgado, Sebastian Knapp
300: Rise of an Empire - Premieres 6/24, (same day as DVD, weeks before Netflix & Redbox), R, Action, Sullivan Stapleton, Eva Green
Winter's Tale – Premieres 6/24, (same day as DVD, weeks before Netflix & Redbox), PG-13, Drama, Colin Farrell, Jessica Brown Findlay
June 2014 Independent Studio & Other Titles of Note** (just a selection)
We have curated a wide variety of films from the top indie studios for Movies On Demand audiences this month. They can see many of June's new releases from indie studios either before or the same day they premiere in theaters.
Pierce Brosnan and Toni Collette star in A Long Way Down, about four suicidal strangers who meet at the precipice of their undoing on a London Tower (hence the film's name,) and form a pact to find ways to keep on living. Dakota Fanning andElizabeth Olsen star as Very Good Girls, who set out to lose their virginity before they go off to college. Also with Demi Mooreand Richard Dreyfuss.
Opposites attract in a new film that is already developing a cult following. They Came Together, starring Paul Rudd and Amy Poehler, is from the same writer/director team as Wet Hot American Summer (David Wain and Michael Showalter).
Indie Films on MOD highlights:
The Pretty One – Premieres 6/3, (same day as DVD), R, Comedy, Zoe Kazan, Jake Johnson
A Long Way Down – Premieres 6/5, (before theatrical release), R, Comedy, Pierce Brosnan, Toni Collette
Ping Pong Summer – Premieres 6/6, (same day as theatrical release), TV-14, Comedy, Susan Sarandon, Joseph McCaughtry
Repentance – Premieres 6/10, (weeks before DVD, Netflix & Redbox), R, Thriller, Forest Whitaker, Anthony Mackie
Tim's Vermeer – Premieres 6/10, (same day as DVD), PG -13, Documentary, Tim Jenison, Penn Jillette, Teller
Hellion – Premieres 6/13, (same day as theatrical release), TV-MA, Drama, Aaron Paul, Juliette Lewis
Lullaby – Premieres 6/13, (same day as theatrical release), R, Drama, Garrett Hedlund, Amy Adams
Ernest & Celestine – Premieres 6/17, (same day as DVD), PG, Animated, voices: Forest Whitaker, Mackenzie Foy
The Final Member – Premieres 6/17, (same day as DVD), R, Documentary
Venus in Fur – Premieres 6/20, (same day as theatrical release), TV-MA, Drama, Emmanuelle Seigner, Mathieu Amalric
Rob the Mob – Premieres 6/24, (same day as DVD), R, Drama, Michael Pitt, Ray Romano
Very Good Girls – Premieres 6/24, (before theatrical release), R, Drama, Dakota Fanning, Elizabeth Olsen
Happy Christmas – Premieres 6/26, (before theatrical release), R, Comedy, Anna Kendrick, Lena Dunham
Radio Free Albemuth – Premieres 6/27, (same day as theatrical release), TV-PG, SciFi, Shea Whigham, Alanis Morissette
They Came Together – Premieres 6/27, (same day as theatrical release), R, Comedy, Paul Rudd, Amy Poehler
*Source, The NPD Group. 1H 2013
**Schedule subject to change. Titles, dates and availability may vary by system. HD and 3D not available in all systems.
These movies are distributed to U.S. cable systems by iN DEMAND, www.indemand.com. For more information about Movies On Demand on Cable, go to www.rentmoviesondemand.com, on-screen guides or cable system websites.
# # #
Contact: firstname.lastname@example.com


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Very interesting details you have noted , thankyou for posting . "The thing always happens that you really believe in and the belief in a thing makes it happen." by Frank Lloyd Wright.


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Laura Bush is the Editor in Chief for BioPharm International
Today?s plenary is the Biemann Medal Lecture, which will be given by Lingjun Li of the University of Wisconsin-Madison. Li is awarded the 2014 Biemann Medal for the number and depth of her contributions in the field of mass spectrometric study of neuropeptides and functional peptidomics.
Today's workshops cover a variety of topics, including protein analysis, -omics, data analysis, a few specific areas of application, and career development.
Today?s plenary is an award lecture by Richard M. Caprioli of Vanderbilt University. Caprioli is the recipient of the 2014 ASMS Award for a Distinguished Contribution in Mass Spectrometry for the development of matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry and its application to molecular mapping of tissues in biology and medicine. His award lecture today will be held in Exhibit Hall AB, at 4:45 pm.
In today?s free tutorials, several very practical topics will be covered, including theoretical and practical aspects of UHPLC, the role of dwell volume in UHPLC method transfer, and how regulations are changing the role of separation sciences
In today?s program, Ron Majors of LCGC, Fabrice Gritti of the University of Tennessee, and David S. Bell of Supelco/Sigma-Aldrich will each present a free tutorial session.
Today, three free tutorial sessions are offered to HPLC conferees. Today?s talks, from Steven Soper, Emily Hilder, and Chris Pohl, cover microfluidics, monoliths, and ion chromatography.
This morning, the ACS Division of Analytical Chemistry Award for Young Investigators in Separation Science will be presented to Michael Roper of Florida State University.
This morning at 8:30, award sessions will be held for two important awards of strong interest to scientists working in chromatographic and mass spectrometry techniques: The Dal Nogare Award from the Chromatography Forum of the Delaware Valley and the Pittsburgh Conference Achievement Award.
A tribute to John Dolan, who is celebrating 30 years of writing the "LC Troubleshooting" column.
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Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies
MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis
LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase
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Lightning One Step Closer To Final Roster
By Matthew Sardo
Managing Editor
Follow @ MatthewSardo
Managing Editor
Follow @ MatthewSardo
Tampa Bay Lightning head coach Jon Cooper spoke to the media Friday after practice about finalizing the roster and who will make the squad.
Cooper continues to stress defense and toughness.
"We instilled want we needed to, a standard of how we want to play," Cooper said.
Tags: Tampa Bay Lightning


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November 26, 2014
MEXICO CITY (AP) - Teachers' protests that have snarled traffic, blocked government buildings and prompted the cancellation of sports events in Mexico City have prompted President Enrique Pena Nieto to change the date of his state-of-the-union address.
The address traditionally delivered around the start of Congress' fall session was scheduled for Sunday. That's the same day a dissident teachers' union plans the latest in a series of protests against the president's proposed education reform. The protests have hampered passage of the reform and Pena Nieto canceled a Monday trip to Turkey in order to push through the legislation.
He told reporters that required a rethinking of the rest of his schedule. His office said Thursday that the speech would be Monday. Mexican media widely interpreted the move as an attempt to avoid the protests.
Copyright 2014 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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Justin Masterson Rumors
Free Agent Profile: Justin Masterson
In 2013, Justin Masterson turned in a career season for the Indians as he pitched to a 3.45 ERA with 9.1 K/9 and 3.5 BB/9, earning an All-Star Game nod and piquing the attention of baseball people everywhere. No one knew where he would wind up after the 2014 season, but everyone agreed that he was in line for a massive contract. Masterson might not get the same long-term haul he once envisioned thanks to a lackluster 2014, but he still figures to get paid this winter.
Everything came together for Masterson in 2013. His power sinker was clicking, he was striking batters out at a career-high rate, and his 3.33 xFIP indicated that he was just flat out good, not lucky. With an aggressive approach on the mound and a 58.5 percent ground-ball rate, Masterson truly realized his potential with the Tribe.
Of course, the main difference between the 2013 and 2014 versions of Masterson was health. Fortunately, he's on the mend from his injuries and should be 100% on all fronts by the start of Spring Training. While others in his position – banged up in a contract year – might have chosen to rest up, Masterson mostly pitched through the pain. At 29, Masterson is younger than most of the quality pitchers available on the open market. And, thanks to the midseason trade that sent him to St. Louis, Masterson can't be hit with the qualifying offer and won't have draft pick compensation tied to him.
His 2014 numbers – a 5.88 ERA with 8.1 K/9 and 4.8 BB/9 – aren't so hot, but the fact that he managed to make 25 starts and 3 relief appearances despite it all is pretty impressive. The righty logged four straight seasons of at least 180 innings for Cleveland and while his ERA yo-yoed – 4.70 in 2010, 3.21 in 2011, 4.93 in 2012, and 3.45 in 2013 – he was solid on the whole and his 11.7 fWAR in that stretch placed him among the top thirty starters in the game. Masterson also hasn't had a ground ball percentage lower than 55.1% in the last five years and he's been around 58% over the last two seasons.
GMs will ask their team doctors to do a thorough check on Masterson before putting pen to paper, but they probably won't fret about the right-hander resting on his laurels and counting his money. It's also worth mentioning that the 29-year-old's xFIP (4.06) and SIERA (4.03) were far kinder to him this year than ERA and his 8.1 K/9 is actually stronger than the average of his previous four seasons. Given time to heal up and iron out the kinks in his delivery, Masterson could get back to his old self rather quickly.
His troublesome right knee, which plagued him for a good chunk of the season, is partially to blame for the down year. That problem seems to be in the rear view mirror but shoulder impingement and a nagging left oblique injury have held him back and adversely altered his mechanics. He's expected to fully recover from all of those injuries with some rest, but teams will certainly be wary and especially thorough in their examinations. Clubs will want to be sure that they're more likely to get the 2010-2013 version of Masterson than the 2014 version.
During Masterson's 2010-2013 run, his fastball had an average velocity of about 92.9 MPH. This season, Masterson threw his heater at a decidedly less warm 90.3 MPH. Faulty mechanics brought on by injury are believed to be culprit for the drop, but teams will still view the decreased velocity as a concern.
Masterson's struggles landed him in the Cardinals' bullpen to finish out the regular season and that's obviously not how St. Louis saw things shaking out when they traded for him at the deadline. The hurler was viewed as a top-of-the-rotation piece just a year ago and he will wind up with relief appearances as the most recent work on his resume. Masterson actually did well in his grand total of 3 and 1/3 innings of bullpen work, but he's obviously looking to join someone's starting five next season.
Earlier this year, Justin and his wife Meryl welcomed twins to the world, a boy and a girl, making their three-year-old daughter a big sister. Justin, the son of a pastor, spends much of his downtime aiding in humanitarian causes both here and abroad with Meryl. This offseason, he'll be heading to Uganda and Kenya on a mission trip to help with water projects and to build orphanages for needy children. The Mastersons founded a non-profit organization (the Fortress Foundation) in 2013 to help extremely impoverished people from all around the world. In Cleveland, they volunteered and donated to Laura's Home, a local battered women's shelter. It's no surprise that the Indians made Justin a repeat nominee for the Roberto Clemente Award.
In the clubhouse, Masterson is known a supportive teammate and someone who is always willing to help out the younger pitchers. At 29, Masterson is still young, but he also has lots of valuable experience to draw from.
If the medicals check out, a team could very well come away with one of the best pitching bargains of the winter. Back in January, when Masterson was coming off of his career year, Tim Dierkes pegged his extension value around $65-$85MM over a five year stretch. Like any free agent, the 6'6″ hurler has his question marks, but he could be a very solid value after an offseason of rest.
Last last month, Patrick Mooney of CSNChicago.com wondered aloud if Masterson could be a fit for the Cubs. His history with former Red Sox GM and current Cubs president Theo Epstein could lead to a union and, as Mooney notes, coach Chris Bosio has a track record for taking his pitchers to the next level. Speaking of the Red Sox, Nick Cafardo of the Boston Globe wrote back in August that Boston will have interest in Masterson in the offseason.
Outside of those old friends, teams in bigger parks with pitching needs like the Twins, Angels, Marlins, and Braves might be in the mix for Masterson.
Expected Contract
Because Masterson's four consecutive strong years were followed by a spotty walk year, it's hard to gauge what kind of contract he'll net this winter. A one-year deal to reassert himself as a top starter could put him in line for a substantial long-term deal. At the same time, it's not hard to envision a team coming to the table with a multi-year offer to Masterson's liking.
If Masterson opts for a one-year deal in order to restore his value and go for a monster contract after the 2015 season, a one-year, $12MM contract could make sense.
Steve Adams contributed to this post. Photo courtesy of USA Today Sports Images.
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Full Story | Comments | Categories: 2014-15 Free Agent Profiles | Justin Masterson | MLBTR Originals | St. Louis Cardinals
Cafardo On Astros, Darvish, Gallardo, Bautista, Kang
The firing of Astros manager Bo Porter and bench coach Dave Trembley was a clash of old-school baseball versus the new-school of analytics and old-school lost, according to Nick Cafardo of the Boston Globe. For that reason, Cafardo opines GM Jeff Luhnow's next hires will need to be data savvy, know their way around a laptop, put numbers ahead of traditional baseball, and accept daily interference. Trembley, who found out he was fired from the ESPN news ticker, wasn't surprised by the dismissals because there was a disconnect with the front office from "the computer leaks to the draft and the Mark Appel situation where the manager wasn't told (top prospect) Appel was coming up to throw. I think (owner) Jim Crane nailed it when he said that there was a personality clash and sometimes people just don't get along."
In other items from Cafardo's Sunday Notes column:
- There is a financial component to placing Yu Darvish on the disabled list. The Rangers can deduct $5,228.75 per day in bonuses over 30 days on the DL and, since the right-hander has been moved to the 60-day disabled list, the savings realized will be nearly $136k on Darvish's $800K roster bonus.
- Justin Verlander's struggles this year should give teams pause about giving large contracts to older pitchers. Cafardo, however, doesn't see this cautionary tale dampening the market for Jon Lester, Max Scherzer, and James Shields because there are franchises which cannot resist the temptation and feel it's the cost of doing business.
- Cafardo views the Red Sox as players for the services of free agents Jason Grilli and Justin Masterson this offseason.
- There is some debate within the Brewers organization about exercising Yovani Gallardo's $13MM option for 2015 with some feeling the money might be better spent elsewhere.
- Expect the Rangers to engage the Blue Jays in trade talks for Jose Bautista, but Cafardo notes Texas may not have the pitching prospects to pry the All-Star slugger away from Toronto.
- Joel Hanrahan, who suffered a setback in his rehab from Tommy John surgery, will not need another operation and will attempt to continue his comeback in 2015. Hanrahan had signed a $1MM deal with the Tigers in May, but never pitched an inning for the organization.
- Korean shortstop Jung-ho Kang will be posted this winter and should be in line for a substantial contract given the lack of available impact power hitters. The 27-year-old, who measures six feet and 180 pounds, hit 38 home runs and drove home 107 runs in 107 games for Nexen of the KBO. Cafardo notes the Cardinals have shown interest in Kang previously, but a few more teams (not named by Cafardo) are now in the mix.
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Full Story | Comments | Categories: Boston Red Sox | Houston Astros | Jason Grilli | Joel Hanrahan | Jose Bautista | Justin Masterson | Milwaukee Brewers | St. Louis Cardinals | Texas Rangers | Toronto Blue Jays | Yovani Gallardo | Yu Darvish
Cafardo's Latest: Bogaerts, Bradley, Phillies, Masterson, Uehara
In the latest edition of his Sunday column, Nick Cafardo of the Boston Globe writes that the early struggles of Xander Bogaerts and Jackie Bradley Jr. have left many around the game wondering how good each player truly is. Bogaerts' youth makes his scuffles more understandable, but one NL adviser said that Bradley has fallen from a prospect that would be the centerpiece of a trade to a "throw-in." The 24-year-old is a standout defender, but he's hit just .208/.284/.303 in 470 big league plate appearances and has shown "absolutely no sign of the hitting getting better," said the adviser. Boston will commit to Bogaerts for next year regardless of his finish, writes Cafardo, but he concludes that Bradley will have to show improvement over the final seven weeks in order to handed the center field job in 2015.
More from his column…
- In 30 years covering baseball, Cafardo says he cannot recall an instance of a team scouting another club as much as the Phillies scouted the Red Sox without pulling the trigger on a trade. The Phillies have continued to send scouts to all three of Boston's post-deadline series, and Cafardo wonders if the team could be preparing for offseason negotiations regarding Cole Hamels. He hears that the Sox, Rangers, Angels, Dodgers and Cubs will be the big players for Hamels this winter.
- The Red Sox will have interest in bringing back right-hander Justin Masterson back to the organization as a free agent this winter.
- James Shields will be one of the most sought-after free agents on this year's market, and while his age presents risk, one AL GM tells Cafardo that being older than Jon Lester and Max Scherzer actually has some appeal: "He's thrown a lot of innings and pitched a lot of games and there's always the possibility of breakdown, but the fact you might be able to get him at a shorter term reduces that big risk."
- "The Phillies are just unreasonable in their demands," an AL official said when discussing the trade market for Jonathan Papelbon. Still, that official feels that Papelbon will indeed be traded in August, though it may not happen until the end of the month when the Phillies will be forced to "get a bit more realistic."
- The Red Sox want to retain Koji Uehara, but they don't want to go as high as the approximately $15MM qualifying offer. It appears that Uehara wants to return, though Cafardo notes that the Orioles could be a factor, as the closer's family makes its home in the Baltimore area.
- The Mariners' Chris Young just picked up his 10th win, but he tells Cafardo that the statistic doesn't mean much to him these days. "Earlier in my career, I think it's something I'd get excited about," he said. "But at this point in my career, I know that wins are so far beyond a pitcher's control. One day, the media will stop evaluating us on that."
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Full Story | Comments | Categories: Baltimore Orioles | Boston Red Sox | Jackie Bradley Jr. | James Shields | Jonathan Papelbon | Justin Masterson | Koji Uehara | Philadelphia Phillies | Xander Bogaerts
Cardinals Acquire Justin Masterson
The Cardinals have bolstered their starting rotation depth by acquiring Justin Masterson from the Indians in exchange for top outfield prospect James Ramsey. Both teams have officially announced the deal. Right-hander Michael Wacha has been moved to the 60-day DL to make room on the Cardinals' 40-man roster.
Masterson, 29, is currently on the disabled list (he's set to be activated this weekend) and in the midst of a down season as he heads into free agency. He's earning $9.7625MM this season, of which roughly $3.3MM remains.
Masterson looked the part of a top-of-the-rotation starter in 2013, posting a 3.45 ERA with 9.1 K/9, 3.5 BB/9 and a 58.5 percent ground-ball rate in 193 innings. He's battled a knee issue for most of this season, which could very likely have contributed to his 5.51 ERA and bloated walk rate (5.1 BB/9).
Masterson's fastball velocity has declined significantly this season, falling from an average of 91.6 mph in 2013 to 89.1 in 2014. However, Masterson's now former pitching coach Mickey Callaway said earlier in the month that he felt Masterson's knee injury had altered his mechanics, which could explain the dip in velocity as well as the increase in walks.
The Cardinals have been on the lookout for rotation help for weeks now, having also been connected to Jake Peavy as well as aces David Price and Jon Lester. Masterson comes with upside, to be sure; FIP, xFIP and SIERA all feel his skill-set should have resulted in an ERA in the low 4.00s this season, and he's had a good deal of past success. However, his injury and ineffective results will leave some Cardinals fans wondering if he's truly an upgrade over internal options.
That remains to be seen, but the Cardinals felt that Masterson could bolster their starting pitching in light of Michael Wacha's injury and the struggles of Shelby Miller. While Adam Wainwright and Lance Lynn are reliable arms atop the rotation, Joe Kelly has been injured for most of the season, and Carlos Martinez would shatter last season's innings total were he to remain in the rotation over the final two months (to say nothing of the postseason).
As for the Indians, they'll receive Ramsey, a 2012 first-round pick that ranked seventh among Cardinals prospects on Baseball America's midseason list and ranked sixth according to Jim Callis and Jonathan Mayo of MLB.com. The 24-year-old is hitting .300/.389/.527 with 13 homers in 281 Double-A plate appearances this season. Callis and Mayo note that Ramsey has the speed to play center field (though he's not a huge threat on the bases) and the arm to play right field if a change is needed. He draws a fair amount of walks and has shown more power than some anticipated coming out of college, the MLB.com duo adds.
Peter Gammons first reported that Masterson was headed to St. Louis (on Twitter), and Joel Sherman of the New York Post was the first to report Ramsey's involvement in the trade (Twitter link).
Photo courtesy of USA Today Sports Images.
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Full Story | Comments | Categories: Cleveland Indians | James Ramsey | Justin Masterson | Newsstand | St. Louis Cardinals | Transactions
Indians Ready To Move Cabrera, Masterson
TUESDAY: Industry perception is that the Indians are ready to move Masterson and shortstop Asdrubal Cabrera, tweets ESPN's Buster Olney.
Cabrera makes for an interesting target, because unlike Masterson, he's enjoying a relatively productive season. Cabrera is hitting .249/.309/.392 as of this writing, and while that's hardly elite, park- and league-adjusted metrics like OPS+ (99) and wRC+ (98) peg him as just slightly below league average. That, of course, is relative to all hitters around the league, but middle infielders come with a lower offensive standard, making the switch-hitting Cabrera's production more valuable.
Defensively speaking, Cabrera doesn't offer much; he's never posted a positive UZR in a sample of 100+ innings, and Defensive Runs Saved feels that he's cost Cleveland 28 runs over the past three seasons at short. However, he's graded out better in his career at second base, albeit in a much smaller sample size (1341 innings compared to 6282 innings at short). Cabrera has about $3.44MM of this season's $10MM salary remaining, and he is a free agent at season's end.
MONDAY: Though he won't be activated from the disabled list until this Friday, the Indians are "very willing" to trade Justin Masterson, sources tell Jeff Passan of Yahoo Sports (Twitter link). Cleveland's preference would be to obtain controllable starting pitching in return for their embattled right-hander.
Masterson has struggled for much of the 2014 season, posting a 5.51 ERA with 8.5 K/9, 5.1 BB/9 and a 58.5 percent ground-ball rate. More concerning, perhaps, is the stark decline in his fastball velocity; after averaging 91.6 mph on his heater in 2013 (and 91.9 mph in 2012), Masterson averaged just 89.1 mph before being placed on the disabled list with a knee injury. Pitching coach Mickey Callaway said before the All-Star break that he felt Masterson's knee injury forced him to alter the way he landed coming off his delivery, which got his mechanics out of sync and could have been partially to blame for the velocity issues.
The 29-year-old is set to become a free agent at season's end, and it seems unlikely that a team would surrender top talent to acquire a two-month rental that has struggled so greatly in 2014. As such (and this is my own speculation), Masterson might be more of an August trade candidate. If he can come back healthy and effective, scouts might be willing to overlook some of his early-season struggles (to an extent).
Masterson is earning $9.7625MM this season after avoiding arbitration for the final time this offseason. Cleveland had interest in extending its now-former ace (Corey Kluber likely holds that distinction now), but even when Masterson himself suggested seemingly below-market two- and three-year deals at $17-18MM annually, the Indians didn't bite. Of course, at this point, that looks like it could have been a shrewd move on Cleveland's behalf.
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Full Story | Comments | Categories: Asdrubal Cabrera | Cleveland Indians | Justin Masterson | Newsstand
AL East Rumors: Lackey, Blue Jays, Masterson
The Red Sox are willing to move one or both of John Lackey and Jon Lester, depending on the returns, sources tell WEEI's Alex Speier. However, while the club is willing to move Lester within the division because he is a free agent at season's end, they're less inclined to move Lackey within the division, as he is controlled through 2015.
Here's more on Lackey and the AL East…
- In a second piece, Speier writes that it will be difficult for the Sox to move Lackey, though, as he's expressed an understandable hesitance to pitch at the league minimum next year, and it would leave the Red Sox with little to no stability in their rotation. Speier suggests a one-year, $16.5MM extension (the AAV of Lackey's current deal, prior to his league-minimum option kicking in), which could feel fair to both clubs. Essentially, it would amount to a two-year, $17MM deal, of course.
- A trade of Lester could impact Lackey's willingness to return to the Red Sox, tweets Ken Rosenthal of FOX Sports. Lackey and Lester are close, and Rosenthal suggests that Lackey may not want to sign an extension or play for $500K next year if Lester is gone.
- Yesterday's acquisition of Danny Valencia may prove to be the biggest move that GM Alex Anthopoulos makes prior to the non-waiver trade deadline, writes Brendan Kennedy of the Toronto Star. The Blue Jays are getting contributions from two of their biggest trade chips — Aaron Sanchez and Marcus Stroman — and the platoon of Steven Tolleson and Munenori Kawasaki has hit well to this point. Anthopoulos is still looking for a right-handed platoon partner for Adam Lind, but Nolan Reimold could fill that void. It seems to me that it's a stretch to count on that many question marks, but Kennedy speculates that the team's payroll limitations may be more significant than Anthopoulos has admitted to the public. Kennedy runs down the pros and cons of some speculative Jays targets.
- While Justin Masterson is similar to Yankees acquisitions Brandon McCarthy and Chase Headley — all are formerly productive players with sizable salaries and diminished production in 2014 — the Yanks aren't interested in acquiring him, reports Joel Sherman of the New York Post. Sherman points out that teams could be more open to acquiring Masterson in August if he clears waivers and begins pitching better following a DL stint, but the Indians, who are still in the Wild Card hunt, may just hang onto him then. Cleveland is "very willing" to move Masterson, who has reportedly drawn trade interest from other clubs.
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Full Story | Comments | Categories: Boston Red Sox | Cleveland Indians | John Lackey | Jon Lester | Justin Masterson | New York Yankees | Toronto Blue Jays
AL Central Rumors: Miller, Gomes, Danks, Sox, Indians, Twins
The Royals are interested in Andrew Miller but aren't currently pursuing Jonny Gomes, Major League sources tell Rob Bradford of WEEI.com. Multiple reports have previously connected the Royals to Gomes, but it appears their interest has waned for the time being. Miller, of course, is being pursued by many teams due to his dominant numbers and relatively inexpensive salary. He'll be a free agent at season's end but could alter the composition of a bullpen and be a vital postseason piece. Miller tells Bradford that if he's traded, he'll harbor no hard feelings toward an organization with which he has "loved" his time. "I sincerely hope it doesn't come to an end in the next couple of days, but if it does it won't spoil it for me," said Miller. "If it does I'm certainly not going to burn a bridge on the way out of town." Earlier this morning, K.C. was also linked to John Lackey.
Here's more from the AL Central…
- Despite reported interest from the Yankees, the White Sox might have a difficult time moving John Danks, a source tells Daryl Van Schouwen of the Chicago Sun-Times. "Anybody who throws 200 innings in the big leagues is worth his weight in gold," the source said. "But I don't think his weight is worth $30 million worth of gold." Van Schouwen's source feels that the Sox would let Danks go if he were to be claimed on waivers next month in order to free themselves of his remaining salary obligations.
- As for Chicago's other tradeable pieces, Van Schouwen notes that Adam Dunn, Gordon Beckham, Alejandro De Aza and Dayan Viciedo have limited markets due to contractual obligations (Dunn) or poor performance (the others). Alexei Ramirez would fetch a nice return, but the ChiSox don't have an in-house replacement for the 32-year-old.
- Paul Hoynes of the Cleveland Plain Dealer looks at the Indians' current situation and feels that the team could sell some veterans without hurting their chances in the Wild Card hunt. Justin Masterson has underperformed, and Asdrubal Cabrera has been decent at best, but both have drawn trade interest, Hoynes reports. He suggests calling Oakland and San Francisco about Cabrera to peddle him as a second base option. Ultimately, the Indians could benefit from relying more on names like Jose Ramirez, Danny Salazar and Zach McAllister than their declining stars, Hoynes writes.
- Glen Perkins made no effort to hide his feelings on whether or not the Twins should extend Kurt Suzuki when asked by Mike Berardino of the St. Paul Pioneer Press over the weekend: "That would be the ideal. I think everyone else would agree. Not even just pitchers. He's fit in this clubhouse great, too, with everybody." GM Terry Ryan told Berardino that he's been happy with Suzuki's contributions, though he acknowledged that Suzuki rates poorly in terms of pitch-framing. Berardino noted that the Orioles, Blue Jays and Giants had scouts in attendance at Twins games over the weekend.
- In more Twins news, Ryan is sending assistant GM Rob Antony on the team's current road trip to Kansas City and Chicago while he settles in with VP of player personnel Mike Radcliff and special adviser Wayne Krivsky to work out deadline deals, writes La Valle E. Neal III of the Minneapolis Star Tribune. Ryan acknowledged the team's position as sellers, telling Neal: "As long as it stops in the near future, then it is worthwhile. … This isn't what anyone signed up to do. Nobody wants to watch a club get into late July and be in a position where you don't have a chance." Neal lists several Twins trade candidates, including Suzuki, Josh Willingham, Brian Duensing and Casey Fien.
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AL Notes: Hamels, Peavy, Yanks, Masterson, Tigers, Angels
Here's the latest out of the American League:
- The Red Sox could be involved as both buyers and sellers, according to reports from ESPN.com's Jayson Stark (Twitter links). After inquiring with the Phillies on lefty Cole Hamels, Philadelphia has sent scouts to watch Boston's Double-A affiliate. Meanwhile, the Red Sox have sent their own "top scouts" to take a look at the Cardinals' New York-Penn League club over the last few days, suggesting that a deal sending Jake Peavy to St. Louis could still be in the offing.
- Though recent reports may (to some extent) suggest otherwise, Yankees GM Brian Cashman said earlier today that the team's priority at this point is to add an "offensive piece," as Bryan Hoch and Jake Kring-Schreifels of MLB.com report. "It still feels like the pitching needs more help, but honestly, the offense has been consistently poor throughout the entire year." Cashman added that, while second base prospect Rob Refsnyder could be the team's "second baseman of the future, maybe as early as next year," he would potentially only see time in the outfield at the MLB level this year and would not represent an immediate upgrade over incumbent Brian Roberts at the keystone.
- Justin Masterson of the Indians may still be working through a rehab assignment, but that has not stopped teams from inquiring as to his availability, Paul Hoynes of the Plain Dealer reports. Hoynes writes that the interest in Masterson suggests both that the trade market for starters is wanting for quality and that teams value players differently, with some potentially willing to bet on a return to the righty's results from 2013. Of course, as manager Terry Francona notes, a healthy and productive Masterson could also provide a significant boost to Cleveland's own chances.
- As they peruse the market from the buy side, the Indians are looking for players with future control rather than rentals, tweets ESPN.com's Jim Bowden. That is unsurprising, given the team's careful resource management and somewhat long postseason odds.
- We learned earlier today that the Tigers are expected to pursue a left-handed reliever. The club does not appear to be in the market for a left-handed hitting outfielder or an infielder to play on the left side, as Chris Iott of MLive.com reports. "I don't know that either one of them would be real high on our priority list at this point," said GM Dave Dombrowski.
- The Angels are unlikely to deal for a starter in advance of the trade deadline, Ken Rosenthal of FOX Sports reports on Twitter. Though the club has some payroll available to make an addition, it is hesitant to ship out more prospects after a series of recent moves.
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Central Links: Alcantara, Bailey, Worley, Masterson, Sox
Originally recalled for a two-day period with Darwin Barney on paternity leave, Cubs second baseman Arismendy Alcantara has been informed that he will be with the team at least through the All-Star break, reports Gordon Wittenmyer of the Chicago Sun-Times. Alcantara, who ranked 33rd on Baseball America's midseason list of the game's Top 50 prospects, says he was surprised by the news. Manager Rick Renteria offered praise for the 22-year-old, who collected his first four Major League hits in today's contest.
Here's more from the game's Central divisions…
- Reds right-hander Homer Bailey left today's game after five innings due to a slight strain in his right knee, but he won't see his name added to the list of significant injuries that have stricken contending teams today. The Reds have announced that he is expected to make his next start.
- Twins GM Terry Ryan tells Mike Berardino of the St. Paul Pioneer Press that he's glad to see Vance Worley performing well with the Pirates, though he did imply that it's too early to say that the Twins gave up on Worley too soon: "Give him a little time to see what he does over the course of starts. We'll talk about that in October. See how it goes. I know he's done well."
- The Indians are hopeful that Justin Masterson's two weeks on the disabled list will not only give him a chance to heal, but to help him get his mechanics back in line, reports MLB.com's Jordan Bastian. Pitching coach Mickey Callaway feels that Masterson's knee has affected the way he's been able to land during his delivery, which would explain the sharp decrease in velocity Masterson has seen this year.
- White Sox GM Rick Hahn would need to receive an offer that knocks his cell phone out of his hands in order to trade Chris Sale, Jose Quintana, Avisail Garcia or Jose Abreu, writes Scott Merkin of MLB.com. However, Hahn notes that oftentimes, a trade will come together when a rival club's initial inquiry is on a player that is unavailable, as it leads to the suggestion of alternative options.
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Full Story | Comments | Categories: Arismendy Alcantara | Avisail Garcia | Chicago Cubs | Chicago White Sox | Chris Sale | Cincinnati Reds | Cleveland Indians | Homer Bailey | Jose Abreu | Jose Quintana | Justin Masterson | Minnesota Twins | Pittsburgh Pirates
AL Central Notes: Masterson, Rodon, Tigers
Indians starter Justin Masterson has been dealing with a "nagging" knee issue since early in the season, reports Paul Hoynes of the Cleveland Plain Dealer. Soreness in his right knee has lingered since his second start of the year, says Masterson, and now will cause him to miss at least one outing. It remains to be seen what this could mean for Masterson's status as a pending free agent (and possible qualifying offer recipient or even trade candidate). The righty has seen his ERA jump from a 3.45 mark over 193 innings last year to the 5.03 level in his 93 frames in 2014, though his peripherals and ERA estimators show less cause for concern. The larger issue, perhaps, is the fact that his average fastball velocity has dropped from 93.1 mph last year down to 90.5 mph this season.
Here's more on Masterson and the rest of the AL Central…
- Meanwhile, in response to a reader question, MLB.com's Jordan Bastian writes that Masterson's diminished velocity may have played a role in the club's decision not to come up to the righty's asking price for an extension. The hurler's historical inconsistency may have been the greater factor, says Bastian.
- White Sox GM Rick Hahn says that recent draftee Carlos Rodon (who went third overall) could be in the club's rotation as early as next year, reports Dan Hayes of CSNChicago.com. "Based on our scouting evaluation that's certainly a possibility," said Hahn. "But until you get a guy in and get to know him and spend day in and day out with him, I think it's a little risky to put time frames on guys." Of course, the first step will be to complete a deal with the lefty, who must sign by July 18.
- Tigers GM Dave Dombrowski acknowledged his team's need for bullpen help to hosts Jim Bowden and Casey Stern on the Inside Pitch show on MLB Network Radio on SiriusXM (via MLB.com's Jason Beck). Dombrowski did note, however, that the team would be looking for more of a middle-relief type of arm than a late-inning option, as they're comfortable with Joba Chamberlain and Joe Nathan in the eighth and ninth innings. Nathan has struggled to a 6.28 ERA this season and briefly looked to have turned a corner, fanning five in a pair of scoreless innings, but he's allowed two runs in two innings since.
- In a mailbag piece with readers, James Schmel of MLive.com writes that he expects the Tigers to acquire some bullpen help this July and suggests Chad Qualls as an ideal candidate. He also opines that if the Rays end up designating Erik Bedard for assignment, the veteran lefty would make a logical addition to Detroit's pitching staff. He also feels that Don Kelly is the most likely roster casualty when Andy Dirks is activated from the disabled list, as that would allow Detroit to keep both Dirks and the surprising J.D Martinez on the roster.
Steve Adams contributed to this post.
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Full Story | Comments | Categories: Carlos Rodon | Chicago White Sox | Cleveland Indians | Detroit Tigers | Justin Masterson


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When the Cullens, including her beloved Edward, leave Forks rather than risk revealing that they are vampires, it is almost too much for eighteen-year-old Bella to bear, but she finds solace in her friend Jacob until he is drawn into a "cult" and changes in terrible ways.
I purchased this book as a gift for the teen of a friend. Unfortunately she had already read it but was very excited to have received the final book in the trilogy. She said she loved the book and the series and would recommend them to any of her peers (she is 13)
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Zoltán Till, Database consultant and developer, Hatekonysag.hu Ltd. Since 2001 he has given more than 100 trainings, in the topics of Access database-development, advanced level Excel, and Excel programming, MS Project and ECDL, among others. Besides that, as a freelance developer and consultant, he has taken part in a number of Excel and Access developments.


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Slide the pieces to move Khun Phaen past all the guards into the position on the right from which he can escape to freedom.
A useful visualising exercise which offers opportunities for
discussion and generalising, and which could be used for thinking
about the formulae needed for generating the results on a
A package contains a set of resources designed to develop pupils'
mathematical thinking. This package places a particular emphasis on
"visualising" and is designed to meet the needs. . . .
Can you maximise the area available to a grazing goat?
In the game of Noughts and Crosses there are 8 distinct winning
lines. How many distinct winning lines are there in a game played
on a 3 by 3 by 3 board, with 27 cells?
What would be the smallest number of moves needed to move a Knight
from a chess set from one corner to the opposite corner of a 99 by
99 square board?
It is possible to dissect any square into smaller squares. What is
the minimum number of squares a 13 by 13 square can be dissected
How could Penny, Tom and Matthew work out how many chocolates there
are in different sized boxes?
ABCD is a regular tetrahedron and the points P, Q, R and S are the midpoints of the edges AB, BD, CD and CA. Prove that PQRS is a square.
A cylindrical helix is just a spiral on a cylinder, like an ordinary spring or the thread on a bolt. If I turn a left-handed helix over (top to bottom) does it become a right handed helix?
Imagine you are suspending a cube from one vertex (corner) and
allowing it to hang freely. Now imagine you are lowering it into
water until it is exactly half submerged. What shape does the
surface. . . .
If you have only 40 metres of fencing available, what is the maximum area of land you can fence off?
A 3x3x3 cube may be reduced to unit cubes in six saw cuts. If after
every cut you can rearrange the pieces before cutting straight
through, can you do it in fewer?
A bus route has a total duration of 40 minutes. Every 10 minutes,
two buses set out, one from each end. How many buses will one bus
meet on its way from one end to the other end?
On the graph there are 28 marked points. These points all mark the
vertices (corners) of eight hidden squares. Can you find the eight
hidden squares?
Lyndon Baker describes how the Mobius strip and Euler's law can
introduce pupils to the idea of topology.
What shape has Harry drawn on this clock face? Can you find its
area? What is the largest number of square tiles that could cover
this area?
A huge wheel is rolling past your window. What do you see?
Every day at noon a boat leaves Le Havre for New York while another
boat leaves New York for Le Havre. The ocean crossing takes seven
days. How many boats will each boat cross during their journey?
These are pictures of the sea defences at New Brighton. Can you
work out what a basic shape might be in both images of the sea wall
and work out a way they might fit together?
Can you find a way of representing these arrangements of balls?
A game for 2 players. Can be played online. One player has 1 red
counter, the other has 4 blue. The red counter needs to reach the
other side, and the blue needs to trap the red.
What is the greatest number of counters you can place on the grid below without four of them lying at the corners of a square?
What happens to the area of a square if you double the length of
the sides? Try the same thing with rectangles, diamonds and other
shapes. How do the four smaller ones fit into the larger one?
Start with a large square, join the midpoints of its sides, you'll see four right angled triangles. Remove these triangles, a second square is left. Repeat the operation. What happens?
What is the shape of wrapping paper that you would need to completely wrap this model?
A 2 by 3 rectangle contains 8 squares and a 3 by 4 rectangle
contains 20 squares. What size rectangle(s) contain(s) exactly 100
squares? Can you find them all?
Can you mark 4 points on a flat surface so that there are only two
different distances between them?
Here are four tiles. They can be arranged in a 2 by 2 square so that this large square has a green edge. If the tiles are moved around, we can make a 2 by 2 square with a blue edge... Now try to. . . .
Can you fit the tangram pieces into the outlines of these clocks?
Take a rectangle of paper and fold it in half, and half again, to
make four smaller rectangles. How many different ways can you fold
it up?
Exchange the positions of the two sets of counters in the least possible number of moves
Can you fit the tangram pieces into the outline of the child walking home from school?
Mathematics is the study of patterns. Studying pattern is an
opportunity to observe, hypothesise, experiment, discover and
Can you fit the tangram pieces into the outline of this shape. How would you describe it?
Draw some isosceles triangles with an area of $9$cm$^2$ and a vertex at (20,20). If all the vertices must have whole number coordinates, how many is it possible to draw?
Can you fit the tangram pieces into the outlines of the chairs?
Can you see why 2 by 2 could be 5? Can you predict what 2 by 10
will be?
Show that among the interior angles of a convex polygon there
cannot be more than three acute angles.
Can you fit the tangram pieces into the outlines of the lobster, yacht and cyclist?
Can you fit the tangram pieces into the outline of this plaque design?
Can you fit the tangram pieces into the outline of Little Fung at the table?
The whole set of tiles is used to make a square. This has a green and blue border. There are no green or blue tiles anywhere in the square except on this border. How many tiles are there in the set?
How many DIFFERENT quadrilaterals can be made by joining the dots
on the 8-point circle?
Can you fit the tangram pieces into the outline of the rocket?
Can you fit the tangram pieces into the outline of the telescope and microscope?
A tilted square is a square with no horizontal sides. Can you
devise a general instruction for the construction of a square when
you are given just one of its sides?
Can you fit the tangram pieces into the outline of this telephone?
Can you fit the tangram pieces into the outline of Little Ming playing the board game?
Use the lines on this figure to show how the square can be divided into 2 halves, 3 thirds, 6 sixths and 9 ninths.


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Rick Ross Speaks On Jay-Z Collaboration, Updates On Health
Ricky Rozay calls his duet with Hov "our biggest collaboration yet."
Rick Ross previously revealed that he netted a collaboration with Jay-Z for his upcoming album God Forgives, I Don't, which he claims is "our biggest collaboration ever." Speaking with Sucker Free's DJ Envy, Ricky Rozay discussed the duet and confirmed it will appear on his 2012 LP.
"You know, whenever me and the homie come together to collaborate, we gotta make it something special for Hip Hop," he said. "We always make sure we have fun with it, but this record right here, this is our biggest collaboration ever. It will be featured on God Forgives, I Don't."
He also reflected on his health scare and pair of seizures, explaining that he's trying to get his life in order and take it easier. The MMG boss says that he couldn't wait to get back to the studio after getting out of the hospital and now has a clean bill of heath.
"Coming out the hospital, you be ready to get back to work. I'm a grinder, I'm a hustler. That's the next order of business. You're so used to moving at 80 miles per hour. I gotta get rest now. Well, I'm supposed to. I try to. That's what it was. I'm blessed, man. I went in and had my MRI and everything came back straight. It was just a case of me being overly exhausted."
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LIVE: Makeover home revealed today
Who is going to pay the increased PROPERTY TAXES. This family is going to be victims of the tax system. Everyone I have spoken to wants to know the answer to this question. Revove this comment again and I will call Channel 9.
'Extreme'-ly at home
How will the family be able to afford the property taxes on this home? Certainly there was a great deal of money put into the renovation of a house which had a mortgage. How can a family with such medical expences expences pay the property taxes and insurance? I have read that most of the people that get the extreme makeover lose thier homes to foreclosue.
Making the Makeover
What happens to the Mortgage on the old house? I understand it was a $50K house that had an increased Mortgage of 200K. The mortgage on the old house will not go away. How will this family be able to pay property taxes on such an adventure with tremendious medical bills? Can anyone explain how this works?
Craft's attorneys file a motion for full custody of children
Ms. Craft will not have to ever work again. Good for her.
Tonya Craft's fate now in jury's hands
I would like to see the faces and hear the grammer of the girls parents. Little girls are known for lying. Little Brittny Spears and Madonna wannabes. Confiscate the kids teen magazines, hardrives, movies and see what Premium channels their parents subscribe to. I can hear the parents now: I'll get you my pretty, and your nice little teaching job too!
Tonya Craft: 'I'm here because I've been falsely accused'
The Basics: You can say anything to DFACS. They Call DA. By Law they are obligated to bring case to trial. You must prove you are not guilty. I think the bottom line is these parents are jelous of the fact the Ms. Craft is single. This is a total waste of money and time.
Defense challenges interviews of children in Craft trial
The children are coached by DFACS. Those ladies at DFACS should be put on trial.
Craft trial entering 4th week
I sat on a case like this as a juror a few years back. The prosicution stacks up the charges. The defendant may be totally innocent but the STATE is obligated to bring the case to trial. Even if it is determined that the people doing the prosecuting are lying, the case goes on. In the case I was on the DA thanked us for bringing a NOT Guilty Decision. Tonya Craft is the real victim in all this. The children are coached by DFACS. The children are coached by DFACS. I think the parents are jelous of Tonya because she is single. On the case I was on the mother was in nursing school and pregnant. Her little 7 year old saw the photos in a TEXT book of male and female parts. She knew what the female part looks like in real life but not the male. The little girl ran and opened the shower door while her father was showering and touched his privite part. The couple was already separated and the wife was bitter. You know how that goes. DFACS + DA + Stupid Parents = Waste of tax payers money.
Get involved to combat gangs, McGary says
Buy a gun and defend your family.
Chattanooga: Budget cut would mean layoffs
If Chattanooga lays off 100 police officers, then I made the right choice in buying a handgun and getting the permit to carry. I had an attempted home invasion 2 years ago but was able to hold the front door shut while they were kicking it. Thanks to the quick action of Fort Oglethorpe Police and Catoosa Co. Sheriff the b a s t a r d s ran away.