text:
I don't know about anyone else but I believe that Joel just bit! As we say here in America Hook, line and sinker! Yeah he is in!
Sorry no THEM I need yo get a new phone! Or read my comments BEFORE I post them!
Yay yup posted more! I love it as always :) Thank you for the dedication too! <3
@RaeKitano Thank you so much for the dedication. I was so surprized and happy. You are so sweet.
Add to your private libraryMy Library
Add this story to your public reading lists


text:
Thank Pokémon for the Cool Transparent 2DS Handhelds
I've always thought the Nintendo 2DS looked, well, terrible. These new 2DS handhelds don't. »
I've always thought the Nintendo 2DS looked, well, terrible. These new 2DS handhelds don't. »
If cute could kill, these two little girls would strike you dead. »
An image that's been circulating since early last month when Square Enix's Bravely Default came out for European 3DS demonstrates how Japan's nearly naked 15-year-olds become Europe's slightly more sensibly dressed 18-year-olds. »
That's not my opinion, mind you. That's what people online in Japan are saying. »
Last Friday, the PS4 launched in Europe. Gamers in Germany were very excited to get the new PlayStation console. Very. »
Some people - who you'd think should know better - got excited last week when they learned that Sega had filed a trademark in Europe for "Shenmue III". The only problem: it wasn't actually Sega who filed it. »
Friday saw the launch of the PlayStation 4 in the U.K., and The Sun's notorious Page 3 treated blokes there to a new model—one much less curvy than usual. »
The PS4 just went on sale in Italy, and the launch event Sony put on in Rome - at the historic Castel Sant'Angelo - looked bananas. »
Those in North America got to do this days ago, but for a lot of other people, the PS4 is something they haven't been able to get their hands on. Until today. »
Last month, Kotaku published images of Taiwanese special forces. They were totally frightening. But Taiwan doesn't have a monopoly on scary troops. Other countries are ready to terrify you, too. »
Wii Karaoke U is a service that's been available in Japan for a while, a built-in app for Nintendo's console that lets users play a basic singing game using their Miis. The game - developed by Joysound - went and hit Europe last month, converted to a downloadable title, and the song selection is...interesting. »
Strange that Nintendo killed the Wii, huh? It just stopped making the console [UPDATE: in Japan, at least]. So sudden! Odder when you consider that the Famicom, released in 1983, was on sale in Japan until 2003. »
In Europe, Nintendo is releasing a new Legend of Zelda themed 3DS XL. It sure is pretty. »
Time for another tale—albeit unconfirmed—of the inside workings of Nintendo, though this one's a little saucier than the last. Because of Europeans and sex shops. Read it here via a 2011 translation of an account that originally appeared on fan site Classic-Zone. A fascinating read about what it might be like to be in… »
A journalist says she was "completely dehumanised" on stage during an Xbox One Event at Eurogamer Expo 2013, by a comedian who made degrading jokes about her gender. Eurogamer Expo says it is investigating the matter. »
The heir to a €50 million fortune has confessed to killing his father with a spiked bat he said was inspired by the weapon in Dead Rising 2. Other ties to video gaming, to say nothing of the wealth involved, have helped in riveting Spain's attention to the June 30 slaying of Andreu Bennasar Coll. »
Microsoft is saying some pricing changes seen by U.K. Xbox Live customers trying out the new Xbox Live beta—in which Microsoft Points are converted to local currency—are an error, and these users will be compensated for the difference. »
When Danny was sixteen, he started collecting Japanese swords. But after he saw The Last Samurai as an adult, he knew swords weren't enough. He wanted his own suit of samurai armor. So, he spent two years of his life making one. »
Somewhere between comics, cartoons, and real life, PaperChildren exist. These are 2D drawings, thrown into 3D space. And they're often adorable. »
The Wii Mini—aka the "most pointless console upgrade of all time"—goes on sale in Europe next month. »

subset: commoncrawl


text:
Castellet Cottage Rental Photos and Description
House just opened; 4habit double, wonderful views, 2 yards, solarium / pool
The 140m2 house RENT WHOLE. His rehabilitation has received citations in recognition of their fine architecture. It is very comfortable. Two floors: On the floor of 70 m2 two bright rooms with two separate environments kitchen, living room and library, and fireplace in the center designed especially for this place. There is also a toilet. And the first floor of 70m2 of great natural light has 4 double bedrooms and a bathroom. A spacious and sunny front yard with great views of the countryside divided into two spaces, one less to eat, play children, make the barbecue and a pergola higher terrace with stunning views of the countryside, l'Arboç with reproduction of 1906 at 1:50 of the Giralda in Seville, lake and river Foix and forests, and a solarium and refreshment and relaxation pool exclusively for guests and where drink nicely on summer nights. In the back there is another patio, cozy and cool is coming from Barcelona airport by car Part AP-7 or by train from Sants station to station
- Suitability:
- Long-term Renters Welcome
- children welcome
- pets considered


text:
Humidity 35%
Winds 6.9mph
Humidity 35%
Winds 6.9mph
Humidity 62%
Winds 3.5mph
Dec 15, 2010 1:12 AM by Lee Douglas
NEW YORK (AP) - Nine teams have been eliminated from playoff contention as the NFL heads into Week 15.
Out of the running are Washington, Minnesota, Detroit, Dallas and Carolina in the NFC. Gone from the AFC are Buffalo, Cincinnati, Cleveland and Denver.
On the verge of elimination are Houston (5-8), Tennessee (5-8) and Arizona (4-9). Although San Francisco also is 5-8, it trails first-place St. Louis and Seattle by only one game in the NFC West with three remaining.
New England (11-2) has secured a playoff berth.
(Copyright 2010 by The Associated Press. All Rights Reserved.)
1 hour ago


text:
DECEMBER 1-4 Tel Aviv, Israel Annual Mtg. of the Israel Medical Assn. Info: Israel Medical Association, c/o The Stier Group Ltd. 28 Hayetzira St. Ramat Gan, 52521 Israel, Ramat Gan, Israel Middle Eas. (972) 3-7516422/3/5/7 1-5 Sarasota, Fl Infectious Diseases in the Outpatient and Inpatient Settings. Info: American Medical Seminars, Inc., PO Box 6129, Sarasota, FL 34278. (941) 388-1766 3 Kingston, Ontario, Canada Back Pain. Info: Continuing Medical Education, Queen's University, 78 Barrie ...
Register for Complete Access (Valid Email Required)
By registering on MeetingsNet now, you'll not only gain access to Printer-friendly, you'll get exclusive access to a large archive of premium content.
Already registered? Log In here.


text:
This is a condition resulting from motility disorders of the esophagus ranging from absent
With time, this disorder may evolve into
Ever had a pain in the butt? No, I am not talking some crazy family member who cannot keep the mouth shut. I am talking about a real pain... Read more »
Learning to live with MS on the long haul is a bit like growing pains within a new relationship. You may be familiar with little MS... Read more »
Esophageal spasms can cause a lot of pain, problems swallowing as well as vomiting. Unfortunately they are also more common in people... Read more »
Full Question:I have had migraines for as long as I can remember. About 4 years ago I started getting muscle spasms only on the left side... Read more »
Last week, I had my monthly massage with Ruth. I love going to see her because (a) she's become a friend; (b) massages (for the most... Read more »
Source: ADAM Encyclopedia
Esophageal spasms are abnormal contractions of the muscles in the esophagus (the tube that carries food from the mouth to the stomach). These spasms... Read more »
Source: ADAM Encyclopedia
Coronary artery spasm is a temporary, sudden narrowing of one of the coronary arteries (the arteries that supply blood to the heart). The spasm slows... Read more »
Source: ADAM Encyclopedia
A vascular spasm is a sudden, brief tightening of a blood vessel. Causes, incidence, and risk factors Vascular spasms (and heart attacks)... Read more »


text:
The penultimate awards night of the North American Irish Dancing Championships saw several new faces being crowned champs at the Disneyworld Resort as the contest entered into its final day.
Bridget Albrades of New York took home first prize in the Girls U8 category, while Farran Dougherty of New Jersey followed immediately after to capture the Girls U9 Bs.
Emily Marino of popular dancing school Rinca na Tiarna in New York, won the Girls U9 As directly afterwards.
Next up was the Girls U11As which Julia O'Rourke from the prestigious Petri school won, then Laoise Curtis from Irish dancing powerhouse Belfast won the Girls U11Bs.
Ellen Kennedy O'Connor from Sligo, Ireland (or 'Eire' as the event organisers prefer to call it) won the Girls U14As, then Ann Paigi Tuilli was crowned winner of the Girls U14Bs after a short interval.
The last result of the night were the Girls U16A age-group which was taken by Sinead Carson of Doherty dancing school in Belfast
Log in with your social accounts:
Or, log in with your IrishCentral account:
Don't have an account yet? Register now !
Join IrishCentral with your social accounts:
Already have an account ? Log in
Or, sign up for an IrishCentral account below:
Make sure we gathered the correct information from you
You already have an account on IrishCentral! Please confirm you're the owner.
Our new policy requires our users to save a first and last name. Please update your account:


text:
Ce Fiore v. Pinkberry
- Bon Vivant May 24, 2007 01:56 PM
I've only been to Pinkberry once (only because I thought that their yogurt was good but not something that I would really crave and think about constantly like Bulgarini's Crema di Limone gelato that reminds me of the Limoncello gelato from Renato Bar in Mondello, Sicily) but when I was in J-Town last night I noticed that a Pinkberry was opening up across the street from Ce Fiore.
I had never been to Ce Fiore but since I like to be counter to what's popular, I decided to become Ce Fiore's best customer. Was I pleasantly surprised! I thought that their frozen yogurt was great! It had a nice balance of tart and sweet (the time that I had Pinkberry it was more on the tart side) and the texture was creamier and not watery like Pinkberry (disclaimer: Pinkberry was a bit watery when I got it).
I topped my frozen yogurt with red beans - fabulous!
re: hazelnutty
It's in Little Tokyo, in the Japanese Village Plaza there in the middle of 1st and 2nd.
re: hazelnutty
There is CeFiore on Lankershim and Magnolia, across the street from the Millenium dance studio. North Hollywood.
I'm like you, I tend to like what's not the most popular. I prefer Fiore to Pinkberry (although I like both). If Fiore was as plentiful as Pinkberry, I'd go to Fiore every time. I like the slightly more variety of flavors at Fiore and the texture/smoothness of the Fiore yogurt is just perfect.
I went last week to CeFiore and also thought it was creamier (less "icy") and not as tart as Pinkberry. I also love that they offer other flavors - blackberry and raspberry/pomegranate.
My sister on the other hand preferred the tarter and icier Pinkberry.
To each his own :)
re: MeowMixx
do they have chocolate flavor or chocolate toppings
re: hazelnutty
They had chocolate chips and white chocolate chips.
re: MeowMixx
Pinkberry will mix flavors, but only in their largest size portion; CeFiore will mixflavors in any size, and has more and better flavors. When the Chowspouse inquired, at a Pinkberry location within the last week, as to any possible reason for the "No Swirl" policy, (other than to extract maximum additional dollars from customers) the explanation was basically "That's the policy".
No avatars, and not refusing to eat at any Pinkberry without an adequate parking lot
re: silverlakebodhisattva
Mix flavors, Pinkberry only has two and frankly I don't consider the green tea a flavor...it does nothing for me.
re: silverlakebodhisattva
Well I dunno if it's just an odd thing with the MDR location, but one possible reason is that they charge more for the Green Tea flavor. Another point for Fiore, all their flavors cost the SAME!
re: Dommy
I was hoping that to be the case when I went yesterday, but seemed to have developed the same policy as PB. They charge more for flavoreds, but I just ordered the plain. Had it with red beans, mochi, and coconut - the guy behind the counter seemed pleased that I tried that combo - gave me a nod of approval. I can easily say that the yogurt and toppings at CF are to my preference, and the mochi did taste like mochi. I still don't know what PB puts on their mochi but it tastes like a dusting of something bitter with a chemical aftertaste. Thumbs up to CF.
re: MeowMixx
Limelight in Sherman Oaks has multiple flavors. In addition to plain and green tea, it has chocolate and mango. I'm not a fan of the other flavors because I find that the flavoring does not mesh with the tartness. However, I love their plain yogurt, and they have more toppings than Pinkberry.
re: pocketsked
I like CF way better. Less crowded, a little less pretentious (although that has changed somewhat with their recent remodel)
That being said, 6 bucks for yogurt? Christ. I used to work at goldenspoon, buck forty five for a cone with almonds!
re: ns1
Stopped by Cefiore/Fiore/If (whatever it's called) in J-town a few week's ago after dinner in the area.
I got the regular with blueberries. I took a nice, big bite only to find out the BLUEBERRIES WERE BAD. They were completely bitter and brown on the inside.
I was so disgusted I felt like my dinner was going to come back up. I told the manager and he didn't seem to care too much, didn't do anything about it.
Can't wait to try Red Mango when it opens...
re: Twinkies
I'm not quite sure what you mean, as there are (at least one) locations (minus the s, perhaps) in the city?
I doubt the Pinkberry franchises would care either
re: Twinkies
Personally, I like Red Mango better than Pinkberry. There definitely is a difference. Whereas Pinkberry is more tart and "icey," Red Mango is creamier, thicker, and less tart.
re: ns1
Golden Spoon is now $1.75 for a mini with no toppings. Still not a bad value, but it's a traditional sweet flavored nonfat yogurt, not a tart yogurt like Pinkberry clones.
Of course nothing beats 99 cents for a Thrifty choc malted crunch ice cream on a sugar cone.
Too bad about those bad blueberries. They didn't offer to remake the order for you with something else? The one time I went to Ce Fiore in Little Tokyo the toppings looked really good, although I just went with the greentea/pomegranate swirl neat.
re: neo949
hahha! i believe they are coming to hollywood as well. right across the chinese mann theatre
re: neo949
The cold war has begun -- LOL. I stopped at pinkberry and brought it out to my wife in the car. She took one spoonful and pushed it away saying, "No, don't eat that. It has gone bad." I told her it is supposed to taste tart. She said, "Tart is tart but that is sour." I finished it but the sour aftertaste stayed with me for several hours -- bad! Once for pinkberry and never again.
I noticed signes all over the Santa Anita Mall in Arcadia "Cifiore coming soon." I also noticed a new Dairy Queen in the food court and I had a really smooth frozen treat there. Not FroYo but neither is pinkberry -- right?
This cefiore web page below list Huntington Beach, Rowland Hts., and Westwood as coming soon. If a download appears just click cancel and then skip the intro. This group is going also heading world-wide.
BF and I tried Ce Fiore in Little Tokyo tonight...
Although the selection of flavors, swirls, and creaminess was nice, we both like the tartness of Pinkberry more. To me, the green tea flavor of Ce Fiore tastes just like green tea ice cream.
We noticed that a Pinkberry store is about to open right across the street from Ce Fiore...
If we had to choose, we would go for Pinkberry, but with the outrageous prices, I'm glad we don't have to. The greek yogurt from Trader Joes or even the Vietnamese yogurt at Banh Mi Che Cali with a variety of fruits and berries from the farmer's market will do just fine for us.
re: Me so hungry
Here's another thread on Pinkberry locations which also discusses Cé Fiore. See my final post with link to recent LA Times article on what's in Pinkberry's product.
re: Me so hungry
i actually think cefiore's yogurt is creamier. pinkberry feels too icy for me.....
re: fergusmccool
The tartness in PB's is not normal... it's ascorbic and citric... my friend who is a nutritional consultant says it's probably citric acid added to the powder...
re: SauceSupreme
Same here. CéFiore is the gold standard. However, I do sneak away to Cantaloop once in awhile for a change. A friend got some of my Cantaloop at work yesterday and enjoyed its unique style: "That's like real yogurt that's been frozen!"
CF definitely. I had CF before ever trying Pinkberry. I was expecting a better consistency and flavor than CF because I bought into the Pinkberry machine. Absolutely no comparison. The blackberry was perfect by itself. Went back a week later to try the raspberry/pomegranate and was impressed all over again at the creaminess and fresh clean flavor. Not a sour note between either of the flavors. The counter help at CFare much more on the ball when you order toppings. Everytime I go to the Pinkberry in Rolling Hills the counter folks have to double check after every ingredient. (And it's never the same person either.) How freakin hard is it to remember three toppings? And what is with only five reaspberries when you order the medium? Oh how I wish they would open a CF in the South Bay. A girl can only dream . . .
After trying Pinkberry in Studio City and Ce Fiore in NoHo, we prefer Pinkberry. Why? The fruit toppings (pineapple, raspberry,coconut) are much fresher at Pinkberry. At CeFiore, the pineapple was brown and not as sweet, the berries were not as good and the shredded coconut was dry, not moist like Pinkberry. As fas as the yogurt taste, we like Pinkberry original the best. The only downside is the hollow center once you eat through the swirl.
re: rad818
Don't you think that going to a frozen yogurt shop for the fruit is like going to a bar for the coasters? I mean, I'm not saying that there's anything wrong with that, but this is the first time I've ever heard this used as the reason.
re: SauceSupreme
You are the wind beneath my wings.
re: SauceSupreme
I look at the yogurt as a blank canvas and the toppings complete the masterpiece. Doesn't the quality of the toppings on a pizza/hot dog/burger/taco/salad/baked potato make a difference to you?
re: rad818
That's still like saying you think Cloris Leachman is hotter that Heidi Klum because she's wearing a better jacket.
re: Woolsey
ROFL! Great analogy!
re: rad818
The quality of the toppings are definitely paramount when talking about the characteristics of an individual food item (a frozen yogurt cup or a pizza or what have you).
But when comparing two food items, the toppings only come into play when I feel the main product itself is close enough.
Take Vito's Pizza for instance. Many people like it. I prefer Village Pizzeria in Larchmont. Why? The toppings. I feel the crust and the sauce and the cheese between the two are similar enough that it comes down to the toppings at Village.
And that's what I'm trying to get at. If you think CeFiore and Pinkberry are similar enough in chilly bliss minus toppings, then I totally respect your opinion, but I just want to make sure that's what you mean.
re: rad818
I'm not trying to be mean or anything; I'm just confused. Normally I'd go to peripheral flavors like toppings only if I've decided that the main flavors are close.
So while you prefer Pinkberry's original flavor the best, do you think that Pinkberry and Ce Fiore's flavors are close enough that the fruit is the differentiator?
re: SauceSupreme
I've had poor-quality fruit at Stinkberry before, too. Just because the shops don't schedule their produce off-days doesn't mean one should be considered uniformly better solely on fruit quality. Moreover, the cheap-o ice milk at Stinkberry has a terrible texture that has only gotten more and more bargain basement as they've expanded their Evil Empire global domination scheme. They've clearly taken to watering down the who-knows-what-it-is even more than they did just eight or nine months ago, to where it's akin to getting a soft-serve sour snow cone. Ick.
Other than Ce Fiore and Pinkberry, there's also Red Mango and Kiwiberri joining into this frozen yogurt battle...
http://www.redmangousa.com/ - vesus -
http://www.cefiore.com/ - vesus -
http://www.pinkberry.com/ - vesus -
http://www.kiwiberri.com/ - vesus -
Who will win? :-)
re: jocey
I need to try Pinkberry's competitors. I haven't had PB in a few months, but I liked it a lot when I had it. The only frozen yogurt I'd had before PB was Penguin's long ago and TCBY more recently. TCBY is sugar paste to me. It's awful. PB was a nice surprise after swearing off TCBY style froyo.
For a taste reference, my perfect refrigerator yogurt is Straus vanilla whole milk yogurt.
re: jocey
I was at Big Chill the other day and had their lemon tart yogurt ("chillberry"). It was yummy, & you can have it on a cone (much better when driving).
I have only had Ce Fiore once & was not persuaded to switch from PB which I love. And yes the quality of the fruit is important to me - that's one of the reasons I like PB so much. I had fabulous blueberries the other day (WH location).
re: kek is khmer
i would also have to vouch for cefiore. there is just no comparison. cefiore is definitely creamier..can't say much for pb, who's i've always said was icier (though people still like to claim it's creamier ?!?!?!?) and what's up with the hole in the middle? as for toppings...i've always found cefiore's to be pretty ripe. and while we're comparing toppings. pb's mochi's are the worst.
CeFiore so far is my favorite after checking out Pinkberry, Kiwiberri and Bliss. Love their mochi topping. I liked the fact that they use stevia instead of sugar.
On limoncello gelato (original note) - recently had a great one at Gelato Paradiso at Fashion Island. I had the Bulgarini's crema di Limone but I have to say Paradiso's better (more tart-lemony).
re: SarahM
I second this strongly. I'm obsessed with their sour cherry syrup stuff. My god. For further proof, do a quick search here on sno la to see that we aren't the only believers.
re: SarahM
Tried Sno:LA. Didn't like it.
For chocolate flavors and other flavors Bliss is better. For creaminess and different flavors Golden Spoon's better (although some of their flavor tasted a tad 'artificial').
For original tart w/ fruit and mochi I much prefer Ce Fiore.
The wood spoon they provided really gave the food an off taste. I applaude their 'greeness' but can't they use some utensil derived from corn instead?
Here's the thing. It seems that people who actually overlook the HYPE of these titles, and actually honestly choose the better place in their opinion, really dig CeFiore. Now, I bet anything that if you took all the insides of CeFiore, and branded it the title, "PINKBERRY" everyone would be madly in love with PINKBERRY. In other words, the title of "Pinkberry" has become such a hype, that people don't even care if CeFiore is so called "better" than pinkberry or whatever... especially young people, they'll go to PB because it's the TITLE and the "THING." I agree though, I think PB is low quality in disguise. When Pinkberry first opened up in Koreatown, i thought it was great. Now that it has expanded, i DO realize the flavor going down a bit. It can't be helped. PB has won the title. In franchises like this, its ALL about winning the name, and they certainly did. CeFiore will probably NEVER be as popular... but those who know it's good, can enjoy it. Besides, why complain that it's not as popular, as long as you KNOW it's better right? ;)
re: AKlRA
The only problem is there's only so many customers and with all the froyo stores popping up like mushrooms after the rain some of them will have to go out of business.
I just hope Ce Fiore will get enough customers to survive.
Saw all the hype of Snola and I have to try it, but if you need a fix near your house/business unless you live near BH it's really either Pinkberry, Kiwiberri or Ce Fiore.
Although PB is indeed watery, a lot depends on the location. I've found that the West Hollywood PB is consistently better than the Abbot Kinney PB. The Abbot Kinney branch looks sickley and transluscent every time.


text:
Behold, the TITCHY T-REX that prowled the warm Arctic of long ago
Paleontologists have discovered the head of a new pigmy breed of Tyrannosaurus rex that roamed the Arctic more than 70 million years ago. The remains of Nanuqsaurus hoglundi, or polar bear lizard, were dug up in 2006, but it is only now that a team from the Perot Museum of Nature and Science in Texas has managed to identify it …
Just to ward off the obvious comments.
Yes, the arctic was subtropical during the cretaceous. No, it was not due to anthropogenic global warming. It was due to Antarctica having not yet drifted into position at the south pole, and to eurasia and north america being stuck together (the atlantic ocean didn't exist yet). This meant that the sea circulated freely at both the north and south pole, which evened-out global temperatures, so the polar areas did never get as cold as they are today. The climate at the most polar areas was of a type which no longer exist: you still had midnight sun / polar nights, but it was never really biting cold, and the area was forested, not tundra.
Yes, this does mean that as the atlantic ocean keeps getting wider and antarctica eventually moves away from the south pole, climate will get warmer again. No, none of this proves that anthropogenic climate change is a fraud committed by tens of thousands of scientists to embezzle the imaginary vast mountains of cash being thrown at science.
Re: Just to ward off the obvious comments.
I thought the most obvious comment was Tiny T-Rex - Marc Bolan?
Re: Just to ward off the obvious comments.
I thought the most obvious comment was this?
And this is filed under Security?
The fossil is securely locked in rock?
Re: And this is filed under Security?
Well would you break into premises guarded by a polar bear lizard?
Re: And this is filed under Security?
Finger trouble. Security and Science look so similar in our publishing system.
Re: And this is filed under Security?
> would you break into premises guarded by a polar bear lizard?
Not more than once anyway.
Re: And this is filed under Security?
Depends if it suffers from the same, "if you fall over, you die" issue big brother had.
Scientists & Marketing
So, Wife is a fancy scientist person who, among other things, works with several foundations that provide funding to many areas of research and she constantly complains that biomed research gets so much of the available funding. She's not alone in thinking there's too much money thrown into that. Promising research is regularly discarded because everybody wants to establish themselves as a 'leader' and years of mindnumbingly boring lab work isn't sexy.
I tell her that the biomed people have such a successful fundraising machine because sick/dying people generate both empathy and sympathy without the need for in-depth marketing strategies. Unless there's some really wonky wiring in your head that kind of stuff just reaches out and kicks you in the shins. Even if you aren't the giving type, sick people at least cause most people to think about things for a minute.
I'm not in anyway trying to say biomed research is taking advantage of sick people, but if somebody throws you an one like that you're really only taking advantage of the sick people if you don't use it to at least try to help.
Regardless, that's what paleontologists (or any non-biomed researchers) have to compete with. You've really got to be on top of your game if you're going to get up in front of a crowd and explain to them that funding your dinosaur research is not a death sentence for the sick child from the earlier presentation. It's obviously a false choice situation, but 'sick and alive' vs 'millions of years dead' is a pretty tough sell (they shouldn't make small grant applicants compete openly with each other if you ask me, but they do, but that's an entirely different issue).
Anyway, the only way you're going to walk out of there and not be seen as the Heir Apparent to The Henry Ford Eugenics Institute is if you move past the false choice mess really quick. Excitement (and tits) are always winners and guess what's exciting? Well, it ain't the 'Polar Bear Lizard'. I'm dead fucking sure of that. If it can't be 'King Lizard' (T-Rex hates sharing glory) make it the Napoleon Lizard (cause it's little, like people think Napoleon was) or the Emperor Lizard. Honestly, it makes absofuckingloutely no difference what you call it, just don't take everything we know about biology and taxonomy and mash them together. They did that with the Platypus and look what that got us. A poisonous Quack Beaver that doesn't even taste good.
Can you imagine Jurassic Park with the 'polar bear lizard' as the final boss? Or any of the worlds great natural history museums with the fucking polar bear lizard as the main attraction. Nobody is going to buy polar bear lizard merchandise and that shits crucially important for covering museum operating costs.
Look, just the other day, STEM focused classes were all over the news. Well, you know that 'S' at the beginning, that's for science. What kind of kid is going to grow up and give any shits about a field where specifics are important if you can just mash shit together as you please. If the kid is intelligent enough to know the meaning of polar, bear and lizard, that kid is also intelligent enough to realize his time of retribution has finally come and he's about to steal your lunch money about .76ms after you say polar bear lizard to him.
I guess the tradition is you get to name what you discover, OK, I'll accept that. But if you're going to call it a polar bear lizard you better make damn sure the 'artists rendering' communicates how badass a polar bear lizard would have to look. You know, posed all angry and covered in the blood of 17,000 natives with blood spurting from the paw that's in the process of regenerating. For a moment I was thinking a saddle too, but that could give the false impression that polar bear lizard gave enough fucks about anyone to let them ride on its back. So I'm going to say a helmet instead. It's a well known fact that you can't trust anyone who wears a helmet, so that should some ummmph to the overall image.
Alternatively, raffle off the naming rights and give the proceeds to some sick kid, maybe even let the kid name it. I bet it would be a better name than 'polar bear lizard'. Getting to name something is a pretty big honor you know. Sure, some dinosaur guy who has been on a peyote induced dream quest for half a decade will think it's funny. But in 3000 years this is exactly the sort of thing that historians will point to and say: 'On your timeline, you will see a sharp decline in education, Human lifespans, and other important indicators of a declining society. What we now call 'The Naming' and the resultant devastation that event caused is why we now execute those who fail to take the science of marketing and brand attribute building seriously'.
Re: Scientists & Marketing
"polar bear lizard" is a dumb name. Got it, thanks.
Re: Scientists & Marketing
It's Biomedical then Engineering(*) and then "others". Between Biomedical and Engineering the rest of the funding is little more than a rounding error.
* Engineering includes topics such as carbon nanotubes and graphene.
Lets clone it.
I want one as a pet to deal with the neighbours cat that keeps shitting in my garden.
Re: Lets clone it.
It's probably like keeping a horse. You need lots of time and space, and it will eat you out of house and home.
Re: Lets clone it.
Probably cost you an arm and a leg too.
Re: Lets clone it. @MrDamage
Have you tried shitting in the neighbour's cat's garden?
(It won't stop the cat shitting in yours, but it might make you feel better)
Re: Lets clone it. @MrDamage
Let me know if you plan on pursuing this approach. I can provide you with a recipe for some nice curried lentils and beans.
Re: Lets clone it.
"You need lots of time and space, and it will eat you out of house and home."
And its leavings are probably far, far worse. And substantially larger than what a domestic cat would leave.
Or a great cat, for that matter.
So, you'd be trading little cat for big scat.
That doesn't sound like a really great deal.
Re: Lets clone it. @MrDamage
Probably best to shit on the neighbour's cat instead.
Re: Lets clone it.
It's probably like keeping a horse. You need lots of time and space, and it will eat you
out of house and home.
Re: Lets clone it.
Yes, but how noisy is the critter? It must somehow live in a quiet cul-de-sac...
Clearly this must have formed part of the Australian mainland during the cretaceous period. Probably killed off by the drop bears.
+1 for the drop bears!!
Very good, but last I checked, the Arctic isn't that close to Australia. (Although, granted, geography was a little different back then)
Drop bears? That wasn't Australia
it was just a place that is very, very, ..... well, ... Australian, except that it had few snakes because they were almost all killed by the spiders (according to Dangerous Mammals, Reptiles, Amphibians, Birds, Fish, Jellyfish, Insects, Spiders, Crustaceans, Grasses, Trees, Mosses and Lichens of Terror Incognita, Volume 29c, Part III).
Nice bar though in Didjabringabeeralong, and I like the way they jailed every prime minister the moment he got himself elected (saves time).
Still, no worries, she'll be right!
Re: (Pendantry)
You're all missing the obvious source of the confusion. The person making the Dropbear statement is incredibly ancient, and things like pole shifts are easily forgotten details when you've got millions of years of things to think about.
You don't have to explain what's cool about a 'Pygmy T-Rex'.
Obvious innit?
See, that's what happens with research.
Find a tiny T. Rex. and someone gets 'rested for crapping in neighbour's garden and animal protection people get uppity 'bout a cat wearing human turd part of which is presently being tested by environment & health for its potential to harm due to combination of curry n beans also presently being researched by several nations warlike development bods as a potentially new biohazard type weapon.
Well, would you like it if that thing that went off covered you in foul smelling poo-like stuff that looked like recently or not so recently digested food?
Although I am a microbiologist and work with things you can't see, I have always been drawn to research on dinosaurs, especially the Tyrannosaurus rex, my favorite. I had an opportunity to witness the development of the Sue exhibit at the Field Museum. When they finally put Sue together in her current erect posture, she was a sight to behold. I still love to imagine the T. rex at the top of its game, even it it was a pygmy version.
I dunno how I am supposed to make any sense of that comparison chart when there is no Double-Decker Bus shown to give me an idea of absolute scale.
Usual shoddy job by El Reg.
Re: Bah!
Absolutely agree.
The Arctic was warm
before the advent of humans - how could this possibly be :-)
Re: The Arctic was warm
What do you mean, before the humans. Get a book.
There's evidence that...
there were periods of global warming before humans too. And actually there was a time when parts of either South America and/or Antarctica poked into the present polar region, and although it got really dark part of the year, was so warm there was jungle then too. This intersected one of the warming periods. The dinos were generally smaller but had huge orbital size for their eye sockets - hence the theory - although geology also confirms much about the weather and plate tectonics position at any time-frame in earth history.
"B" in the infographic....
Is one big-ass scary lizard! I could probably take it at arm-wrestling though.
Re: "B" in the infographic....
As long as Mr. T-Rex doesn't eat you first...
Most read
- Product round-up Too 4K-ing expensive? Five full HD laptops for work and play
- Review We have a winner! Fresh Linux Mint 17.1 – hands down the best
- Vid Antarctic ice THICKER than first feared – penguin-bot boffins
- 'Regin': The 'New Stuxnet' spook-grade SOFTWARE WEAPON described
- You stupid BRICK! PCs running Avast AV can't handle Windows fixes


text:
Adventures of Biscuit :
Black ice
Breaking point
Clifford the big red dog : the show-and-tell surprise
Clifford's best school day
Dancing with the star
The mayor : how I turned around Los Angeles after riots, an earthquake, and the O. J. Simpson murder trial
Michael Vey : Hunt for Jade Dragon :
Mom's best made easy
The...Oak Leaves : the yearbook of Meredith College, Raleigh, North Carolina.
Taste of home simple & delicious cookbook
Too cool for rules
Your dog : the owner's manual : hundreds of secrets, surprises, and solutions for raising a happy, healthy dog
A is for Airplane/A Es Para Avion
Amor verdadero
Apagar el Incendio! = Fight This Fire!
Arrorro, Mi Nino
Barefoot to Billionaire: Reflections on a Life's Work and a Promise to Cure Cancer
Betrayed : a Rosato & Associates novel
Cantame una Cancion [With CD (Audio)]
Cha-Cha-Cha en la Selva [With CD] = The Animal Boogie
Clifford keeps cool
Clifford's best friend : a story about Emily Elizabeth


text:
To think it must be me - re friends etc(49 Posts)
Ann44 Tue 12-Feb-13 19:24:13
Ann44 Thu 14-Feb-13 13:46:06
Ann44 Thu 14-Feb-13 13:43:39
MonstrousPippin Wed 13-Feb-13 18:41:25
glenthebattleostrich Wed 13-Feb-13 17:44:50
THERhubarb Wed 13-Feb-13 17:00:22
THERhubarb Wed 13-Feb-13 16:53:16
Pigsmummy Wed 13-Feb-13 16:52:31
paulapantsdown Wed 13-Feb-13 16:38:58
DontEvenThinkAboutIt Wed 13-Feb-13 16:24:04
SoleSource Wed 13-Feb-13 14:20:49
Ann44 Wed 13-Feb-13 10:46:50
HoleyGhost Wed 13-Feb-13 10:31:29
glenthebattleostrich Wed 13-Feb-13 10:26:45
mayihaveaboxofchoculaits Wed 13-Feb-13 10:18:55
Ann44 Wed 13-Feb-13 09:35:46
Longtalljosie Wed 13-Feb-13 06:20:28
Imaginethat Wed 13-Feb-13 06:09:37
HoleyGhost Wed 13-Feb-13 05:57:36
LilMissSunshine9 Wed 13-Feb-13 00:47:02
SoleSource Tue 12-Feb-13 22:57:48
Tulahoob Tue 12-Feb-13 22:24:44
FeeFiFoMum Tue 12-Feb-13 22:17:36
Whitegrenache Tue 12-Feb-13 22:04:32
Ann44 Tue 12-Feb-13 22:02:01
SoftKittyWarmKitty Tue 12-Feb-13 21:20:32
Join the discussion
Registering is free, easy, and means you can join in the discussion, get discounts, win prizes and lots more.Register now
Already registered with Mumsnet? Log in to leave your comment or alternatively, sign in with Facebook or Google.
Talk: Customise | Unanswered messages | Getting started | Acronyms | FAQs
Threads: Active | I'm on | I'm watching | I started | Last 15 minutes | Last hour | Last Day
Please login first.


text:
Damascus House Rental Photos and Description
4 BR, 2 1/2 Baths, Commercial Kitchen, Fireplace, Private Decks and Porches
Only 2 hours from Manhattan nested between the Catskills and Pocono's, this spectacular home is located on a private and gated 144 acre 'one of a kind' park like setting and has a private mile of Delaware River waterfront.
This breathtaking property is perfect for quaint memorable family gatherings, and activities such as fly fishing retreats.
If you can pull yourself away, there are several quaint local towns (Callicoon, Narrowsburg and Jeffersonville, NY) or (Damascus and Tyler Hill, PA) within a 10 minute drive for antiques, groceries, farmers markets, boutiques, golfing, tennis, canoeing, kayaking, skiing, snow shoe, sleigh riding, bowling, movie theater, Fort Delaware, fine dining and The Bethel Woods Arts Center (original Woodstock site) featuring well know performances.
Activities are limitless! Hiking, biking, horseback riding, swimming, playgrounds, and true Fly Fishing waters (Guides available). The most difficult part of your stay will be leaving paradise.
Paradise: Imagine being surrounded by a mile of Delaware River shore wrapping around you on a 144 acres of endless views, open hay fields, wooded trails to roam and a private mile of waterfront to relax and play! There is even a quaint private playground on the property for kids. Unforgettable wildlife that surrounds you. Eagles flying above, deer roaming the meadows and you may even see a reindeer...we did!
Activities: Game Room on lower level with ping pong, pool table and large screen TV.
Campfires with fire wood and cooking grill at a special campsite available
Playground, sand box and swing set near by on property
Guided Fishing available (reservations required)
Relax: After a day of site seeing, fishing, hiking and activities, come home to a massive cozy fireplace and enjoy the timberframe, lodge like setting
- Suitability:
- Minimum Age Limit for Renters
- children welcome
- non smoking only
- pets considered
About David and Desiree
David and Desiree grew up locally both connected to family farms and continue to raise their family and farm in Damascus. They co-own and direct several well established specialty manufacturing and related service companies associated with television, film, corporate, public spaces and museums.
We both wandered this property as teenagers not together but separately. Ironically, after marriage, we had an odd opportunity to purchase this beautiful farm which was once all cornfields as we remember back when we were kids and now lush hay fields. We still walk the land reminiscing with each other how special it was for both of us back then and now. It's a special moment as you continue through the gate and come around the corner...Its hard to describe.
We decided to purchase the property with dear friends of ours and constructed a magnificent custom passive solar timber frame home for them doing much of the work ourselves. Our friends since have moved out west giving us first option to keep the land intact but decided not to move into this home because our current home and stables are very special and hand crafted from a design done in high school.
When we travel with our four children, we always seek accommodations that are most like home and clean. We manage, care for and clean this home ourselves as a family, with care we would want and with the goal you will never forget your stay at Waterside. Many Guests say 'that our words and pictures can't explain this place' We take great pride in the hand craftsmanship, its cleanliness and presentation. In the winter...we even try to take time to welcome you a warm glow in the fireplace upon your arrival as we do in our own home after a long day on the road.
David and Desiree purchased this house in 2005
Why David and Desiree chose Damascus
Waterside is a 'one of a kind' equisite hand crafted Passive Solar Timber Frame Log Home on gated 145 prestine acres with a mile of private Delaware River Front. Most guests cant imagine it until they arrive. Many of guests often tell us, 'your words pictures DO NOT do this home justice'. One guest figured out it was like having a home all by itself in the middle of the town of Hoboken along the river.
What makes this house unique
Comfort, amazing kitchen, massive cozy fireplace, radiant heat and warm feet, endless views, seclusion, privacy, wildlife, the fish stories, paddling home, freedom...most guests have plans but never leave the front gate after check in....
Guestbook comments from the owner
I have wanted to plan a family trip with my family, in-laws, nephews and all the dogs for about 4yrs. Finally the moment came when I found the Boyce home on Homeaway.com. It accommodated everything for everyone, which as I'm sure some know is difficult to find, plus tack on having a space for all our dogs was a job in itself to seek. So when I was able to put this together and spend 7 days in a beautiful home with all that I love, it was truly a blessing and having all the memories to hold on to, will simply be something that I will stay with me forever, or at least till next year so we can continue on in our chapters of our lives! It was wonderful, breath taking, peaceful and magical in many ways! A place to me better than a dry hotel, or an over crowed anything anywhere! Family is a blessing and Nature is a gift, so enjoy and embrace both to the fullest!
Best Wishes to all that come through the doors of the Boyce Home!


text:
Purveyors of Good Times
Welcome to Spirited Wines. We are a UK wine merchant offering a fantastic range of wines and spirits from around the world which can be purchased online or from one of our many stores around the country.
We believe choosing a wine or spirit should be fun so we have designed this website with that in mind. Feel free to use our Aromatags or food pairings to help guide your choice.
- Camillo de Lellis Biferno Riserva 2009Aglianico, Montepulciano, TrebbianoSausages
- Steak
- Petites Récoltes Vin de Pays de la Vallée du Paradis 2013Cabernet Sauvignon, Carignan, Cinsault, Grenache, Merlot, SyrahPork Chops
- Les Champs Clos Sancerre Blanc 2013Sauvignon BlancGoat's Cheese Tart
- De Gras Sauvignon Blanc 2013Sauvignon Blanc
- La Poussie Sancerre 2013Sauvignon BlancGoat's Cheese Tart
- Petites Récoltes Vin de Pays des Maures Rosé 2013Cinsault, GrenacheSoft Cheese
- Domaine Ott 'Cuvée Marine' Bandol Rosé 2013Cinsault, Grenache, MourvèdreRabbit
- Château Cavalier Provence Rosé 2013Cinsault, Grenache, SyrahSoft Cheese
- Roast Pork
- Pork Chops
- Soft Cheese
Wine of the week
- Champagne Henriot Brut SouverainChardonnay, Pinot Meunier, Pinot Noir
White Fish
- £27.28
- 75cl
News from Twitter
follow @spiritedwines
- Do you need to smell wine to enjoy it? - via @Telegraph http://t.co/NzkBm4bKKw
- $15 million Colorado mansion has a wine cellar that looks like a mine tunnel via @BuzzSumo http://t.co/E4aHxsaFaA
- Beaujolais on the go - http://t.co/12ei1w1B0J
- Do you know what makes a wine organic or biodynamic? #SpiritedChristmas http://t.co/8dGS5066zX
- RT @SWofEnglandsLn: Hello folks ! our new #Christmas magazine has just landed in-store. It is indeed very informative and fun ! http://t.c…


text:
Ecotoxicology is an international journal devoted to presenting fundamental research on the effects of toxic chemicals on populations, communities and terrestrial, freshwater and marine ecosystems. It elucidates mechanisms and processes whereby chemicals exert their effects on ecosystems, and examines the impact caused at the population or community level. The journal is not restricted with respect to taxon or biome, presenting papers that indicate possible new approaches to regulation and control of toxic chemicals and that formulate ways of conserving threatened species. The journal includes not only original research papers but technical notes and review articles, both invited and submitted. A strong, broadly based editorial board ensures as wide an international coverage as possible.
- 23 Volumes
- 150 Issues
- 1,899 Articles
- 56 Open Access
- 1992 - 2014 Available between
Latest Articles
Influence of BBP exposure on nervous system and antioxidant system in zebrafish
Can Zhang, Xue Yang, Zhen He, Qiu Zhong, Jia Guo, Xiao-jing Hu, Li Xiong… (December 2014)
Effect of triclosan on reproduction, DNA damage and heat shock protein gene expression of the earthworm Eisenia fetida
Dasong Lin, Ye Li, Qixing Zhou, Yingming Xu, Di Wang (December 2014)
Preliminary study of interactivity between mercury and cells labeled with carboxymethyl chitosan coated quantum dots
Zhenyu He, Honghao Zhu, Peijiang Zhou (December 2014)
- Journal Title
- Ecotoxicology
- Coverage
- Volume 1 / 1992 - Volume 23 / 2014
- Print ISSN
- 0963-9292
- Online ISSN
- 1573-3017
- Publisher
- Springer US
- Additional Links
- Topics
- Industry Sectors
Continue reading...
To view the rest of this content please follow the download PDF link above.


text:
Find records of Nassima Makdessi
Find birth, death, marriage, military, and other records of Nassima Makdessi at Ancestry.com.Search for records
Biography & Family History Add details
Nassima Makdessi (1908 - 2002) was born on October 1, 1908. Nassima was born into the Makdessi family.
Nassima had no-known spouses. Nassima died on December 22, 2002 at 94 years of age.
Nassima Makdessi's last known residence is at Upland, San Bernardino County, California.
We were able tolocate a death record for Nassima Makdessi in the United States Social Security Master Death Index (SSDI). According to information provided to the SSDI, this death record has been verified by a family member of the deceased. This data can be considered very accurate. What is the SSDI?
This look at Nassima Makdessi's history is a collaborative effort by AncientFaces members Share what you know to reach the people who knew her. Some things we would like to know about Nassima's genealogy:
- What gender was Nassima?
- Where was Nassima born?
- Where did Nassima die?
- Who was Nassimas family?
- What did Nassima look like? Add some photos of their life.
Family Tree & Genealogy Add / Edit People
You can add or remove people from this genealogy by clicking here.
History of Nassima Makdessi Add details
- Given name
- Nassima
- Surnames
- Makdessi family history
- Last Known Residence
- Upland, San Bernardino County, California
- Born
- Death
Do you know more about Nassima Makdessi?
You can add details to this page and share Nassima's story.
Obituary Add details
We don't know details regarding the obituary records of Nassima Makdessi. You can add obituary information about Nassima Makdessi by clicking "Add Details".
Discuss Nassima
Share your memories below with the rest of Nassima's family. We'll notify anyone else who is searching for Nassima of your message.
Find records of Nassima Makdessi
Find birth, death, marriage, military, and other records of Nassima Makdessi at Ancestry.com.Search for records


text:
Pool fence, portable crib, portable highchair, baby monitor, and stroller available for your use!!
(ask for pictures please)
Beautiful beaches just 5-7 minutes away!!!!!
Located in an upscale gated community offers fantastic shopping, awesome restaurants and only 15 minutes from the airport (RSW/Ft Myers)!
Newly remodeled! Approximately 3100 feet all together! Beautiful updated kitchen with gorgous granite tops and attached bar.
Once a model home, this beautifully landscaped house has a huge partially covered screened in lanai (seats many!) that overlooks a large lit pool and beautiful private views of the lake and golf course. The most scenic view in the community!
Totally awesome beaches are just 5 to 7 minutes away. They offer para-sailing, jet-ski rental, volleyball and much more!!
Want to enjoy a nite in? Check out our board games. Fun for the entire family!l!
Beautiful Sanibel and Captiva Islands are less than an hour away!
Drive into old Naples, (20 min) and enjoy fine dining and quaint shopping.
Ft Meyers has much to offer only 20-25 minutes away!
Try your luck at a newly remodeled, (and new addition too) casino just a quick 45 minutes away!
Dog track only a 5 minutes drive!
Coconut Point has great shopping as well as lucious restaurants. 3 other malls, as well as an outlet mall are all within 10-15 minutes away.
Like hockey? See them live at the Germain Arena (just 10 min away)!
Two gigantic putt-putt courses are only a mile away down Bonita Beach Rd.
You will love it! A good time will be had by all!
|Rate Period
|Weekend Night
|Monthly *
Apr 1 2015 - Jun 1 2015
30 night minimum stay
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.
Jan - April- $5500 per month
Nov - Dec- $5200. per month
May - $4000 per month
June - August $3750 per month
September - October $4000. per month
November - December $4500 per month
Holidays- prices may vary
11% Florida rental tax
$250. Cleaning/exit fee
$1000-$1500 Security Deposit
Full payment due 60 days prior to rental
Please. No pets or smoking.


text:
Please login to visit this page or feature. If you are not a member, please click SignUp to register first.
Sign Up
CAPTAINS!! *Please read all the sign up procedures*. To completely sign up a team you must:
*For instructions on using imleagues go to cwu.edu/rec/registration
*ALL PARTICIPANTS will be required to sign a waiver agreement before they are able to participate. Waivers will be made available to participants at their first game.
*Follow us on Twitter @CWUIMSports for more opportunities to win prizes!
The Intramural Sports staff can be reached at 509-963-3511 or email@example.com.
Alder Recreation Complex
1015 East 18th Avenue, Ellensburg, WA 98926, USA
Sun-Sat: 8:00 AM to 5:00 PM


text:
decision levels of the operational hierarchy are fully integrated through the shared use of consistent, robust models. Models serve as the central repository of process knowledge. Information flows from the lower levels to the higher levels to ensure that decisions fully consistent with the status and capacity of the production resources are made.
The third area of need is in the development of tools to support the overall business decision processes. The objective is to expand the envelope beyond the process itself and to encompass the business processes that are essential to driving manufacturing and the entire supply chain. The tools include improved sales and market forecasting methodologies, supply and logistics planning techniques, methodologies for quantitative risk assessment, optimization-based plant scheduling methods, business modeling frameworks, and approaches to dynamic supply chain optimization. Optimization-based scheduling requires the solution of very high dimensionality models expressed in terms of discrete 0-1 variables. The key need is to be able to solve scheduling problems with hundreds of thousands of such variables reliably and quickly. Such capabilities need to be extended to allow treatment of models that encompass the entire supply chain and to quantitatively address business issues such as resource and capital planning associated with the supply chain, siting of new products, and the impact of mergers and acquisition on the supply chain.
Finally, in order to realize the benefits of the developments in the other three areas, it is necessary, indeed essential, to create training methodologies for the work force. These computer-based training methodologies must make efficient use of students' time, recognize differences in levels of expertise, and employ extensive visualization tools, including virtual reality components. Methods must also be developed to aid process staff in the understanding of models and the meaning of the solutions resulting from the various decision support tools that are based on these models. Such understanding is critical both to the initial adoption of such models and to the continuous improvement process, as it is only from understanding the constraints of the existing operation and their implications that cost-effective improvements can be systematically generated.
In conclusion, the process-operations-specific information systems and technical computing developments outlined above are essential to the realization of the goal of the dynamically optimized supply chain. Continuing increases in computing power, network bandwidth, and availability of faster and cheaper memory will no doubt facilitate achievement of this goal. However, the scope and complexity of the underlying decision problems require methodological developments that offer effective gains orders of magnitude beyond the likely increases in raw computing power and communication bandwidth. Process-oriented technical computing really does play the pivotal role in the future of process operations.


text:
Review Summary
Lilyette® Comfort Devotion Strapless - 0822
$37.99 Original Price $38.00
Savings: $0.01 (0%)
- Stay-put technology
- Convertible and adjustable straps for wardrobe versatility.
- Super soft hook and eye closure
- Nylon/Elastane
- Hand Washable
- Imported
Shipping your purchase is easy on belk.com. Depending on the destination of your package, you can expect it to arrive within 4-7 business days. Shipping Information
Returns are easy on belk.com. Easy returns
More from: Lilyette®


text:
Search pictures and profiles of Senior Singles near you right now. Discover how online dating sites make finding singles in the United States, Canada, and all over the world simple, safe and fun! Once you browse profiles and pictures start flirting, messaging and connecting with other members of the SeniorPeopleMeet.com community. Search today and find other sexy, intelligent singles for casual dating or a serious relationship in your area.Search Single Senior Men | Search Single Senior Women
A little about me...
I will tell you later - send me a message.
About the one I'm looking for...
I am looking for a pretty face, a shapely body and a sharp mind. Also I am very active. You know the old saying work hard play hard. I work out 3 to 4 + days per week. Going out to movies, dinners and community functions are things best done with company. Agree :)
I do travel a lot with my job so am not a permanent fixture but recurring presents.Will treat a lady as she needs to be treated. Not a great dancer but like to get out there and do my best.
I'd just like to add...
Send me a message.
Meet Senior Singles
in your State


text:
There's a reason you associate our accent with fashionable music of the last fifty years. We've produced some great bands. The thing is, there's a whole undercurrent you're missing out on over there. You know you have favorite obscure American bands, who you'd go and see whenever they come through t ... More >>
Mind Spiders, Lenguas Largas, Occult Detective Club Monday, October 8, at Rubber Gloves Rehearsal Studios When Mind Spiders' front man Mark Ryan transitioned from the studio to a live band in 2010, it was a breath of fresh air for the DFW punk scene. Since then, he's steered clear of the one-man sho ... More >>
Sunday, April 22, at FC Dallas Stadium
With the 22nd annual Edgefest approaching this Sunday, we started to get a little cultural vertigo looking at the lineup: Garbage, Cake, Evanescence? The Black Keys are the big draw, sure, but it brought us back into that late '90s vortex, where the pants were wide and pop music was at its cavity-ti ... More >>
Usually with this column, we might interview one or two people from a band. With Darstar, all five members were kind enough to share the first shows they saw and played. And, if you wanted a reminder of how effective Smashing Pumpkins were in their heyday, listen to what Lisa Hardaway has to say.
A pretty slow Wednesday evening musically, but at least there's a nice triple-bill of up-and-comers at Andy's for anyone who wants to head to Denton. And, if you're feeling sentimental, you can head to the arts district and catch a Peter Cetera-less Chicago playing with the DSO...
Your daily dose of national music news for Tuesday, November 2, 2010...Sure, Kim Kardashian is hot, but, being hot doesn't mean you're a singer, right?You know you've made it when Cracker Barrel is distributing your new album! Since her acting career didn't quite take off the way she had hoped, Shi ... More >>
Well, the weekend's here, thank the Lord. And, as always, we're here to present you with your concert-attending plans. First, as always, the shows we've already hyped...Tonight, Bill Callahan stops by the Granada Theater, Colourmusic pops on in to The Cavern and The Edge Steals Christmas out at t ... More >>
No one loves Vic Chesnutt like Vic Chesnutt
November 12 - 18, 1998
No, the Toadies haven't broken up. They're just taking their own sweet time
The man who made a career out of ugly music makes a beautiful record
Some sticky PR won't hold Slow Roosevelt back


text:
For us, the accessories we use are an extension of who we are and the magic we perform. The Fly Trap is not only a replacement to the popular Goshman Coin Pouch, but a bold leap forward in design, rich with possibilities previously un-imagined in the world of coin tricks. We dare you to think different.
"Great design. I liked it the moment I saw it." - David Roth, Expert Coin Magician
Leather craftsmanship by Avund Goods in Southern California.
Available in two sizes designed to hold four coins each.
Need some of those antique coins? We offer those as well.
Dan and Dave have been called "visionaries" in the art of magic and cardistry. They are world renowned for their unique style and transformation of the craft into visual art. As professional instructors of magic with years of experience authoring books and producing DVDs, they understand the core concepts and techniques used by today's most acclaimed magicians and can help you become the next.
Reviews (2)
2 Item(s)


text:
By Megan O. Read | Friday, January 08, 2010
We recently had two new staff authors join lynda.com and would like to introduce them to you. In addition to the talented Garrick Chow, Dave Rivers, and Jan Kabili, who we count on regularly for their expert content, we have just added James Williamson and Simon Allardice to the team. Welcome!
Left: James Williamson; Right: Simon Allardice.
You might recognize James from any one of his EIGHT Dreamweaver courses already in the lynda.com library. I caught up with James to see what he was most looking forward to.
"I'm really excited to be on board as a full-time author," James told me. "To be honest, I'm probably most excited about the opportunity to take my titles further and go into projects in more detail. I'm always very interested in teaching WHY we do things, in addition to HOW. I think understanding the 'why we do this' can make people better designers."
I asked veteran language coder Simon Allardice the same question.
"The feedback from my recent iPhone SDK course has been fantastic—and everyone wants more!" he replied. "So it wouldn't surprise me if more advanced SDK titles appeared on the horizon. But you won't see me being just 'the iPhone SDK guy'; expect a lot of different subjects. Sure, they'll all skew to the technical side, but I love jumping between technologies. Apple to Microsoft to Linux, iPhone to SharePoint to .NET, it's all good. I'm a sucker for a new device, piece of software, or system, and always interested in finding the quickest way to learn and teach it. If I'm feeling generous, I'll say I'm a renaissance geek; it's entirely possible I just have a really short attention span."
We look forward to lots of great training from these two valued additions to our team, and hope you all enjoy!
By Megan O. Read | Thursday, October 29, 2009
This week at lynda.com was wall-to-wall authors! In the booths we had authors recording training on Photoshop, Cinema 4D, Mac OSX Server, audio apps, Dreamweaver, and digital photography. Quite a mix! It's a great group with some familiar faces, and talented new faces as well. To unwind from recording, and celebrate these inspiring authors, all went out on Wednesday night with Ms. Lynda.
From left to right: author G.W. Childs, acquisitions manager Joe Randeen, author James Williamson, author relations manager (your's truly) Megan Read, producer Tom Mueller and wife Sally, author Sean Colins, producers Nick Brazzi, Kirk Werner, Max Smith, Senior Director of Education and Content Planning Laurie Burruss, author Ian Robinson, author Chris Orwig, co-owner Lynda Weinman, and author Deke McClelland.
You can change your email preferences at any time. We will never sell your email. More info
Follow lynda.com:
Thanks for signing up.
We'll send you a confirmation email shortly.
Sign up and receive emails about lynda.com and our online training library:
Here's our privacy policy with more details about how we handle your information.
Keep up with news, tips, and latest courses with emails from lynda.com.
We've updated our terms and conditions (now called terms of service).Go Review and accept our updated terms of service.


text:
Accomplished career educator, writer, editor, historian will happily assist students of any age to write, read, learn basic math, science, or language, or for test prep of various kinds (GED, SAT, PSAT, etc.). Will gladly offer structural or editorial suggestions for revision or improvement of writ...
33 Subjects: including Italian, reading, LSAT, ACT English
Oakland, CA
...Before that I worked for two years at a United Nations agency in Rome, Italy, where I used Italian and Spanish. While completing my B.A. Degree in Spanish (Cum Laude Honors), I studied both Italian and French during college.
4 Subjects: including Italian, English, Spanish, French
San Francisco, CA
...I earned a B.A. at UC Berkeley, and an Master's in Education at Harvard University. I will teach you to communicate effectively in English, and give you the tools to continue to learn English throughout your life. I specialize in pronunciation, and pronunciation correction.
13 Subjects: including Italian, Spanish, English, writing
San Leandro, CA
...I'm a strong reader, and I can help you improve your reading skills, no matter how old you are! As a native speaker of English who learned fluent Spanish without living abroad, I am in a unique position to assist English speakers who need to improve their Spanish skills. My strength in Spanish grammar comes directly from my strength in English grammar.
25 Subjects: including Italian, Spanish, reading, English
San Ramon, CA
...I am currently working on my PhD in Romance Linguistics from UC Berkeley (2011-Present).
I hold a BA in Spanish from Indiana University-Bloomington (2011), and am currently working on my PhD in Romance Linguistics at UC Berkeley (2011-Present). I began learning Spanish fifteen years ago, and too...
5 Subjects: including Italian, Spanish, Latin, Portuguese
Albany, CA


text:
Village Crossing Apartments
View property, WalkScore, and Driving Directions
Fax: (352) 373-7683
Village Crossing offers affordable one bedroom apartment homes. Apartment features include spacious floorplans, superior grade flooring, private patio, vertical blinds, walk in closets, dishwasher/garbage disposal, kitchen pantry, linen closet and so much more! Move in today and enjoy our wonderful community amenities including sparkling pool with new sun deck, refurbished clubhouse with new business computer center, laundry facility, fitness center, roving courtesy patrol and much much more!
Ask About Our Great Specials!
Floorplans and Pricing
1 Bedroom
|1 Bedroom 1 Bath
|1 Bathroom
|$480 - $606
|Check Availability
2 Bedrooms
|2 Bedroom 2 Bath
|2 Bathrooms
|Check Availability
Features and AmenitiesBack to Top
Special Features
- One Bedroom Apartments
- Fitness Center
- Swimming Pool
- Business Center
- Picnic Pavilion
- Public Transportation
- On site laundry facility
- Near Shopping
- We Accept Pets Under 25 Pounds
- Walk-In Closets
Community Features
- Apartment
- Business Center Onsite
- Club House
- Disability Access
- Fitness Center
- Freeway Access
- Housing Vouchers Welcome
- Laundry Facility
- Market Rate
- Pool
- Public Transportation
- Standard
- Surface Lot
- View
Apartment Amenities
- Air Conditioning
- Broadband Internet Access
- Cable or Satellite
- Carpet
- Dishwasher
- Garbage Disposal
- Internet Access
- Patio or Balcony
- Walk In Closets
- Washer Dryer Hookup
- Water Sewer and Trash
- Window Covering
Additional Information
Apartments in Community: 91
Pet Policy
We accept pets under 25 pounds. Please call for details.
- Cats Allowed
- Pets Allowed
- Small Dogs Allowed
Local Schools
- Abraham Lincoln Middle School
- Eastside High School
- Lake Forest Elementary School
- Williams Elementary School
We believe school data to be accurate, but do not guarantee that. Please be sure to verify where your children will attend school before making your housing decision.
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.


text:
- freely available
- re-usable
Biosensors 2012, 2(4), 396-404; doi:10.3390/bios2040396
Published: 9 October 2012
Abstract: Angiotensin II is a key regulator of blood pressure and cardiovascular function in mammals. The conversion of angiotensin into its active form is carried out by Angiotensin I-Converting Enzyme (ACE). The measurement of ACE concentration in plasma or serum, its enzymatic activity, and the correlation between an insertion/deletion (I/D) genetic polymorphism of the ACE gene have been investigated as possible indicators of superior athletic performance in humans. In this context, other indicators of superior adaptation to exercise resulting in better athletic performance (such as ventricular hypertrophy, VO2 max, and competition results) were mostly used to study the association between ACE I/D polymorphism and improved performance. Despite the fact that the existing literature presents little consensus, there is sufficient scientific evidence to warrant further investigation on the usage of ACE activity and the I/D ACE gene polymorphism as biomarkers of superior athletic performance in humans of specific ethnicities or in athletes involved in certain sports. In this sense, a biomarker would be a substance or genetic component that could be measured to provide a degree of certainty, or an indication, of the presence of a certain trait or characteristic that would be beneficial to the athlete's performance. Difficulties in interpreting and comparing the results of scientific research on the topic arise from dissimilar protocols and variation in study design. This review aims to investigate the current literature on the use of ACE I/D polymorphism as a biomarker of performance in humans through the comparison of scientific publications.
1. Introduction
The aim of this review is to discuss the current applications of the ACE I/D genetic polymorphism as an indicator that individual athletes possess characteristics which are advantageous from the perspective of achieving better athletic results, or better training outcomes.
In this context, the word "biomarker" is utilized to indicate a substance, its activity (in the case of enzymes), or a genetic characteristic which provides an indication that an individual possesses certain characteristics. Specifically, that ACE concentration, activity, or genetic polymorphism can be used as a form of identification of individuals with improved athletic ability, or who achieve better results in certain athletic competitions.
In regard to the term "superior athletic performance" some explanation is required. Due to the variety of methods utilized in the papers included in this review, this term is loosely applied in the text as an indication that individuals demonstrated improved results during exercise training and/or athletic competition. Parameters utilized in the assessment of this improvement include well established variables such as ventricular hypertrophy as a result of controlled exercise, VO2 max, competition results, heart rate, standardised exercise testing, and time to recovery after exercise.
Genetic polymorphism: Although several genetic polymorphisms for the ACE gene have been identified in humans, the insertion (I)/deletion (D) polymorphism of a 250 base pair alu fragment on intron 16 of the ACE gene, which is located on chromosome 17, accounts for 47% of the variation in ACE activity in circulation [1]. Therefore the focus of this review is on this particular I/D polymorphism in humans, although two other polymorphisms are briefly mentioned.
2. Materials and Methods
In preparation for a Doctoral thesis [2], articles found on the University of Melbourne search engine associated with the keywords Angiotensin Converting Enzyme and athletic performance; Angiotensin Converting Enzyme and genetic polymorphism and athlete, dating from 1978 to 2011 were initially acquired for inspection. The University of Melbourne search engine includes databases such as Scopus, Medline (ISI), and CAB. Reading of the abstracts of approximately 3,000 journal articles returned from the initial search led to the separation of 551 articles of some relevance to the topic of ACE as an indicator of superior athletic activity in various forms. In the preparation of this review, only articles directly related to the use of the ACE I/D genetic polymorphism as a biomarker of athletic performance in humans, dating from 1997 to 2011 were included. Older references were included in the section detailing the renin angiotensin system.
3. The Renin-Angiotensin System
The main interest in ACE arose from the fact that its activity was easily determined from blood samples and that variations from expected levels were found in certain diseases. The other major source of interest was the fact that certain drugs could inhibit the action of ACE, helping modulate the vasopressor response originating from the production of ANG II and aiding in controlling hypertension. More recently ACE activity has been demonstrated to correlate to genetic components and to athletic aptitude, which enlarged the clinical importance of ACE as a biomarker for performance prediction [3,4,5,6].
The Renin-Angiotensin System (RAS) is a peptidergic system that possesses endocrine characteristics. Renin is secreted by juxtaglomerular cells of the kidneys, mostly in response to reduced renal blood flow. Sodium depletion and direct adrenergic stimulation can also produce renin release [7].
Renin is a protease responsible for cleavage of the tetradecapeptide angiotensinogen, produced in the liver, into the active Angiotensin I (ANG I) [7,8]. Cleavage of Angiotensinogen occurs at the Leucine10-Valine11 in humans [9]. Once Angiotensin I is formed, it is converted into Angiotensin II (ANG II) mainly in the lung circulation [8,10] but also in other vascular beds [7]. The enzyme responsible for conversion of ANG I into ANG II is Angiotensin I-converting enzyme (ACE).
Both ANG I and ANG II have vasoconstrictive properties and are involved in the control of mean arterial pressure both at rest and during exercise [10], although ANG II is more potent than its precursor. Angiotensin II, in conjunction with potassium levels, stimulates production and release of aldosterone and stimulates thirst and drinking reflexes [10]. Angiotensin II activates specific receptors in the vascular smooth muscle causing release of calcium from the sarcoplasmic reticulum. This calcium binds to calmodulin and causes vasoconstriction through contraction of vascular smooth muscle [7].
4. ACE Genetic Polymorphism and Performance in Humans
The characteristics of the ACE gene and the insertion/deletion polymorphism on intron 16 were described in the early nineties [2,11,12] but it was only in 1997 that a possible correlation between ACE I/D polymorphism, ACE activity in blood and factors affecting athletic performance was suggested [3]. Based on previous knowledge that the RAS regulates left ventricular growth, Montgomery and his collaborators [4] decided to test the association between ACE genetic polymorphism and improved athletic performance [3,5,6]. Since these first publications, several more addressed the issue of a possible association between ACE and individual characteristics which could result in better results from exercise training or better performance in athletic competitions [3,4,5,6,13,14,15,16,17]. The literature review suggests, although not unanimously, that athletes who present the ACE DD genotype, and therefore higher ACE activity in blood, demonstrate better results in sports which require speed, such as sprint running. On the other hand, individuals with the II genotype, and therefore a lower ACE activity in blood, demonstrate better results in sports requiring endurance, such as cross-country skiing, and mountaineering. However, there is impressive variation in the populations of athletes studied, their training regimes, and the sports practiced.
What seems to emerge from the publications is that certain ethnicities appear to demonstrate a stronger association between ACE activity or I/D polymorphism and athletic results. It also seems evident that individuals participating in certain endurance sports demonstrate more benefit from having the II genotype in comparison to other endurance sports. The key to the problem seems to be the separate investigation of ethnicities and sports, utilizing measurements of performance that can be utilized regardless of the type of training instituted.
Table 1 summarizes the work conducted by research groups which focused on the measurement of ACE I/D polymorphism in association with ventricular hypertrophy, the latter being a measurement of appropriate response to training.
|Table 1. Summary of publications addressing the association between the I/D ACE polymorphism and ventricular hypertrophy as an indication of improved athletic ability and/or training in a variety of athletic modalities, athlete quality and ethnicities. Table adapted from previous work by the authors [1].
|Number of subjects
|Variable assessed as indicator of superior athletic ability
|Measurements remarks
|Special training protocol
|308 Caucasian soldiers
|10 weeks military training
|left ventricular hypertrophy
|pre-training versus post-training
|DD genotype associated with left ventricular hypertrophy post training
|80 Finish athletes
|4 different sport modalities with different training regimes
|left ventricular hypertrophy and ventricular mass
|compared a sedentary group with the athletes in a single measurement
|No association between ACE I/D polymorphism and ventricular hypertrophy
|43 runners
|left ventricular hypertrophy
|single measurement
|D allele associated with greater left ventricular hypertrophy
|28 professional footballers
|left ventricular hypertrophy
|pre-training versus post-training
|D allele associated with greater left ventricular hypertrophy
Three of the four studies found a positive association between the presence of the D allele (or the DD genotype) and greater ventricular hypertrophy in response to exercise, despite the variation in sport, and training regimes. Only one of the studies [13] had a training protocol designed specifically to test improvement in fitness during the experiment, while the others [4,14,18] utilized whatever training the athletes were being subjected to, as part of their routine.
The study utilizing Finish athletes [18], did not find an association between the I/D polymorphism and ventricular hypertrophy, however they found that another polymorphism (M235T) in the ACE gene actually correlates to greater ventricular hypertrophy. This was however the only published study focusing on the M235T polymorphism.
Other studies investigated the association between ACE and other indicators of improved athletic ability, such as VO2 max, and observed no differences between the distribution of ACE genotypes in endurance athletes in comparison to sedentary subjects [19]. However, the same research group has included the ACE gene as a potential source of physical characteristics of interest in athletes [20,21,22]. A different ACE polymorphism (T allele for the ACE T-3892C) was found to be associated with an improvement in the VO2 max of Korean women submitted to 12 weeks of endurance training [23], although the I/D polymorphism was not investigated. It is very unlikely that a single genetic polymorphism would be positively associated to all established measurements of superior athletic ability, which does not invalidate the use of the I/D polymorphism as an indicator of the degree of cardiac hypertrophy in response to exercise.
A summary of publications investigating the use of ACE I/D genetic polymorphism as a predictor of superior athletic performance in high calibre athletes can be found in Table 2.
|Table 2. Summary of studies that focused on performance results and its association with the ACE I/D polymorphism, or frequency of I/D alleles, in athletes, in comparison to controls.
|Number of subjects
|Variable assessed as indicator of superior athletic ability
|Measurements remarks
|high altitude mountaineers
|number of successful climbs above 8,000 m
|single measurement compared to achievement
|I allele associated with improved endurance
|60 Spanish athletes
|cycling, running, handball
|frequency of alleles in elite athletes
|single measurement compared to competition result
|I allele more frequent in athletes in comparison to controls
|64 Olympic athletes
|frequency of alleles in professional athletes
|single measurement
|I allele more frequent in elite rowers
|91 Olympic athletes
|frequency of alleles in elite athletes in comparison to controls
|single measurement
|I allele more frequent in elite runners
|447 athletes
|frequency of alleles in association with performance results
|single measurement
|I allele associated with best finishing times on South African born Ironman athletes
|88 Turkish athletes
|frequency of alleles in association with performance results
|single measurement
|D allele associated with better performance in short sprints
|192 athletes
|6 different modalities
|frequency of alleles in athletes in comparison to controls
|single measurement
|No difference in the frequency of the alleles between athletes and controls
|56 elite athletes
|frequency of alleles in elite athletes grouped by distance
|single measurement
|D allele present in higher frequency in short distance swimmers
|281 Kenyan athletes
|long distance running
|frequency of alleles in athletes in comparison to controls
|single measurement
|No difference in the frequency of the alleles between athletes and controls
|121 elite Israeli runners
|79 Marathon runners and 42 sprinters
|frequency of alleles in elite athletes grouped by distance
|single measurement
|D allele in higher frequency in Israeli sprinters
What emerges from the analysis of the studies listed in Table 2 is that the ACE I/D polymorphism seems to imprint positive characteristics in athletes devoted to certain sport modalities, and certain ethnicities. The studies which failed to demonstrate that certain alleles were more frequent in athletes in comparison to the general population usually included various ethnicities, and multiple sports modalities were grouped together when the comparisons were made. Again it seems unlikely that the ACE gene would have a "blanket" effect in conferring superior qualities to all athletes, from all ethnicities, in whichever sport. The key to the applicability of the ACE gene in detecting better athletes seems to lie in determining in which sports, and which ethnicities, the correlation is strong enough to warrant further investigation.
Another interesting observation is that of the frequency of alleles according to the characteristics of the sport modality: In general, it appears that the I allele is more frequent in athletes competing in longer events, while the D allele seems to be seen in excess in athletes participating in short duration competitions.
Most of the publications found a positive association between the alleles in the I/D ACE polymorphism and a characteristic that allowed some athletes to be more successful than others. In some studies the use of superior performance as a variable might be arguable, since the definition of superior performance is subject to interpretation. For that reason, a better definition of improved or superior performance, or of "elite athlete", is warranted in future studies.
The most common finding was that the D allele, and even more so the DD genotype was associated with greater ventricular hypertrophy [4,13,14], therefore contributing to better cardiac output. In relation to the I allele, the most common findings related to better outcomes in training and competition in sports such as Triathlon [15], distance running [24], and Olympic sports requiring endurance [6,25]. However, a study focusing exclusively on Kenyan athletes failed to demonstrate the association between the polymorphism and quality of the athletes [17].
Studies involving Olympic athletes [6,25], regardless of the sport category found that the I allele was associated with better performance, again in sports requiring endurance. The study investigating triathletes [15] also found an association between the I allele and better finishing times, although the study found marked differences regarding ethnicity of the individuals and the ACE polymorphism results. These results may reflect that the DD and II genotypes affect a variety of factors, not just through blood pressure, but have other effects on cardiac size, tissue perfusion and muscle oxygen transport, and that these differences may be partially influenced by ethnicity. It is obvious from the results concerning the I/D polymorphism of the ACE gene, as most genetic factors are, that the situation is much more complex than a linear positive correlation between a polymorphism and better performance, but that does not exclude benefits to be gained in increased knowledge about interactions between the ACE gene and environmental factors that might contribute to a more appropriate phenotype for the execution of a specific sport.
5. Conclusions
There is a considerable amount of information available relating to ACE and its genetic polymorphism in humans, including its potential use for identification of elite athletes. However, repeatability is lacking and the variation in study design and the population studied has prevented a final conclusion to be drawn regarding the usefulness of ACE as a biomarker of performance in human beings. However, there seems to be more evidence supporting the fact that ACE II polymorphism (and lower ACE activity) has a correlation with aptitude for sports requiring endurance, while the DD polymorphism (and higher ACE activity) relates to sprint ability. Similar correlations between ACE genotype and activity and improved athletic performance have been demonstrated in other species, such as horses [2]. Several paradoxes still need investigation before a definite answer regarding the value of I/D polymorphism in predicting athletic ability can be presented. These include: the effects of ethnicity, sport modality, variables influencing post-translational shedding of ACE, and the effects of local RAS in athletes.
- Rigat, B.; Hubert, C.; Alhenc-Gelas, F.; Cambien, F.; Corvol, P.; Soubrier, F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990, 86, 1343–1346, doi:10.1172/JCI114844.
- De Mello Costa, M.F. Angiotensin-Converting Enyzme (ACE) in Horses and Its Relationship to Performance and Fitness. Ph.D. Thesis, The University of Melbourne, Melbourne, Victoria, Australia, 2010.
- Montgomery, H.; Marshall, R.; Myerson, S.; Clarkson, P.; Dollery, C.; Haynard, M.; Holliman, D.E.; Jubb, M.; World, M.; Thomas, E.L.; Brynes, A.E.; Saeed, N.; Barnard, M.; Dell, J.D.; Prasad, K.; Rayson, M.; Talmud, P.J.; Humphries, S.E. Human gene for physical performance. Nature 1998, 393, 221–222, doi:10.1038/30374.
- Montgomery, H.E.; Clarkson, P.; Dollery, C.M.; Prasad, K.; Losi, M.A.; Hemingway, H.; Statters, D.; Jubb, M.; Girvain, M.; Varnava, A.; World, M.; Deanfield, J.; Talmud, P.; McEwan, J.R.; McKenna, W.J.; Humphries, S. Association of angiotensin-converting enzyma gene I/D polynorphism with change in left ventricular mass in response to physical training. Circulation 1997, 96, 741–747, doi:10.1161/01.CIR.96.3.741.
- Montgomery, H.; Clarkson, P.; Barnard, M.; Bell, J.; Brynes, A.; Dollery, C.; Hajnal, J.; Hemingway, H.; Mercer, D.; Jarman, P.; Marshall, R.; Prasad, K.; Rayson, M.; Saeed, N.; Talmud, P.; Thomas, L.; Jubb, M.; World, M.; Humphries, S. Angiotensin-converting enzyme gene insertion/deletion polymorphism and response to physical training. Lancet 1999, 353, 541–545, doi:10.1016/S0140-6736(98)07131-1. 10028982
- Myerson, S.; Hamingway, H.; Budget, R.; Martin, J.; Humphries, S.; Montgomery, H. Human angiotensin I-converting enzyme gene and endurance performance. J. Appl. Physiol. 1999, 87, 1313–1316. 10517757
- Bowen, I.M.; Marr, C.M.; Elliot, J. Drugs acting on the cardiovascular system. In Equine Clinical Pharmacology, 1st ed.; Bertone, J.J., Horspool, L.J.I., Eds.; Elsevier: London, UK, 2004; pp. 193–215.
- McKeever, K.H.; Gordon, M.E. Endocrine alterations in the equine athlete. In Equine Exercise Physiology; Hinchcliff, K.W., Geor, R.J., Kaneps, A.J., Eds.; Saunders Elsevier: Philadelphia, PA, USA, 2008; pp. 274–300.
- Robertson, J.I.S.; Nicholls, M.G. The Renin-Angiotensin System; Gower Medical Publishing: London, UK, 1993; Volume 1, p. 511.
- McKeever, K.H.; Gordon, M.B. Endocrine alterations in the equine athlete. In Equine Sports Medicine and Surgery, 1st ed.; Hinchcliff, K.W., Kaneps, A.J., Geor, R.J., Eds.; W.B. Saunders: Philadelphia, PA, USA, 2004; pp. 793–814.
- Rigat, B.; Hubert, C.; Corvol, P.; Soubrier, F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase1). Nucl. Acid Res. 1992, 20, 1433.
- Hubert, C.; Houot, A.M.; Corvol, P.; Soubrier, F. Structure of the angiotensin I-converting enzyme gene. J. Biol. Chem. 1991, 23, 15377–15383.
- Fatini, C.; Guazzelli, R.; Manetti, P.; Battaglini, B.; Gensini, F.; Vono, R.; Toncelli, L.; Zilli, P.; Capalbo, A.; Abbate, R.; Gensini, G.F.; Galanti, G. RAS genes influence exercise-induced left ventricular hypertrophy: An elite athletes study. Med. Sci. Sport Exercise 2000, 32, 1868–1872, doi:10.1097/00005768-200011000-00008.
- Nagashima, J.; Musha, H.; Takada, H.; Awaya, T.; Oba, H.; Mori, N.; Ohmiya, K.; Nobuoka, S.; Murayama, M. Influence of angiotensin-converting enzyme gene polymorphism on development of athlete's heart. Clin. Cardiol. 2000, 23, 621–624, doi:10.1002/clc.4960230814.
- Collins, E.; Xenophontos, S.L.; Cariolou, M.A.; Mokone, G.G.; Hudson, D.E.; Anastasiades, L.; Noakes, T.D. The ACE gene and endurance performance during the South African Ironman triathlons. Med. Sci. Sport Exercise 2004, 36, 1314–1320, doi:10.1249/01.MSS.0000135779.41475.42.
- Cam, F.S.; Colakoglu, M.; Sekuri, C.; Colakoglu, S.; Sahan, Ç.; Berdeli, A. Association between the ACE I/D gene polymorphism and physical performance in a homogenous non-elite cohort. Can. J. Appl. Physiol. 2005, 30, 74–86, doi:10.1139/h05-106.
- Scott, R.A.; Moran, C.; Wilson, R.H.; Onywera, V.; Boit, M.K.; Goodwin, W.H.; Gohlke, P.; Payne, J.; Montgomery, H.; Pitsiladis, Y.P. No association between angiotensin converting enzyme (ACE) gene variation and endurance athlete status in Kenyans. Comp. Biochem. Physiol. 2005, 141, 169–175, doi:10.1016/j.cbpb.2005.05.001.
- Karjalainen, J.; Kujala, U.M.; Stolt, A.; Mäntysaari, M.; Viitasalo, M.; Kainulainin, K.; Kontula, K. Angiotensin Gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes. J. Amer. Coll. Cardiol. 1999, 34, 494–499, doi:10.1016/S0735-1097(99)00199-0.
- Rankinen, T.; Wolfarth, B.; Simoneau, J.A.; Maier-Lenz, D.; Rauramaa, R.; Rivera, M.A.; Boulay, M.R.; Chagnon, Y.C.; Perusse, L.; Keul, J.; Bouchard, C. No association bewteen the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J. Appl. Physiol. 2000, 88, 1571–1575. 10797114
- Rankinen, T.; Perusse, L.; Rauramaa, R.; Rivera, M.A.; Wolfarth, B.; Bouchard, C. The human gene map for performance and health-related fitness phenotypes. Med. Sci. Sport Exercise 2001, 33, 855–867, doi:10.1097/00005768-200106000-00001.
- Perusse, L.; Rankinen, T.; Rauramaa, R.; Rivera, M.A.; Wolfarth, B.; Bouchard, C. The human gene map for performance and health-related fitness phenotypes: The 2002 update. Med. Sci. Sport Exercise 2003, 35, 1248–1264, doi:10.1249/01.MSS.0000078938.84161.22.
- Bray, M.S.; Hagberg, J.M.; Perusse, L.; Rankinen, T.; Roth, S.M.; Wolfarth, B.; Bouchard, C. The human gene map for performance and health-related fitness phenotypes: The 2006-2007 update. Med. Sci. Sport Exercise 2009, 41, 35–73.
- Bae, J.S.; Kang, B.Y.; Lee, K.O.; Lee, S.T. Genetic variation in the renin-angiotensin system and response to endurance training. Med. Princip. Pract. 2007, 16, 142–146, doi:10.1159/000098368.
- Álvarez, R.; Terrados, N.; Ortolano, R.; Iglesias-Cubero, G.; Reguero, J.R.; Batalla, A.; Cortina, A.; Fernádez-García, B.; Rodríguez, C.; Braga, S.; Alvarez, V.; Coto, E. Genetic variation in the renin-angiotensin system and athletic performance. Eur. J. Appl. Physiol. 2000, 82, 117–120, doi:10.1007/s004210050660.
- Gayagay, G.; Yu, B.; Hambly, B.; Boston, T.; Hahn, A.; Celermajer, D.S.; Trent, R.J. Elite endurance athletes and the ACE I allele- the role of genes in athletic performance. Hum. Genet. 1998, 103, 48–50, doi:10.1007/s004390050781.
- Woods, D.; Hickman, M.; Jamshidi, Y.; Brull, D.; Vassiliou, V.; Jones, A.; Humphries, S.; Montgomery, H. Elite swimmers and the D allele of the ACE I/D polymorphism. Hum. Genet. 2001, 108, 230–232, doi:10.1007/s004390100466.
- Amir, O.; Amir, R.; Yamin, C.; Attias, E.; Eynon, N.; Sagiv, M.; Sagiv, M.; Meckel, Y. The ACE deletion allele is associated with Israeli elite endurance athletes. Exp. Physiol. 2007, 92, 881–886, doi:10.1113/expphysiol.2007.038711.
© 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).