text:
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
; ; et al
in Retrovirology (2012), 9
BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) and type 2 both target T lymphocytes, yet induce radically different phenotypic outcomes. HTLV-1 is a causative agent of Adult T-cell leukemia (ATL ... [more ▼]
BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) and type 2 both target T lymphocytes, yet induce radically different phenotypic outcomes. HTLV-1 is a causative agent of Adult T-cell leukemia (ATL), whereas HTLV-2, highly similar to HTLV-1, causes no known overt disease. HTLV gene products are engaged in a dynamic struggle of activating and antagonistic interactions with host cells. Investigations focused on one or a few genes have identified several human factors interacting with HTLV viral proteins. Most of the available interaction data concern the highly investigated HTLV-1 Tax protein. Identifying shared and distinct host-pathogen protein interaction profiles for these two viruses would enlighten how they exploit distinctive or common strategies to subvert cellular pathways toward disease progression. RESULTS: We employ a scalable methodology for the systematic mapping and comparison of pathogen-host protein interactions that includes stringent yeast two-hybrid screening and systematic retest, as well as two independent validations through an additional protein interaction detection method and a functional transactivation assay. The final data set contained 166 interactions between 10 viral proteins and 122 human proteins. Among the 166 interactions identified, 87 and 79 involved HTLV-1 and HTLV-2 -encoded proteins, respectively. Targets for HTLV-1 and HTLV-2 proteins implicate a diverse set of cellular processes including the ubiquitin-proteasome system, the apoptosis, different cancer pathways and the Notch signaling pathway. CONCLUSIONS: This study constitutes a first pass, with homogeneous data, at comparative analysis of host targets for HTLV-1 and -2 retroviruses, complements currently existing data for formulation of systems biology models of retroviral induced diseases and presents new insights on biological pathways involved in retroviral infection. [less ▲]Detailed reference viewed: 14 (2 ULg)
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection
; ; et al
in PLoS ONE (2009), 4(6), 6093
The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus ... [more ▼]
The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these cells together with an efficient HAART has been proposed as an adjuvant therapy aimed at decreasing the pool of latent viral reservoirs. Using the latently-infected U1 monocytic cell line and latently-infected J-Lat T-cell clones, we here demonstrated a strong synergistic activation of HIV-1 production by clinically used histone deacetylase inhibitors (HDACIs) combined with prostratin, a non-tumor-promoting nuclear factor (NF)- kappaB inducer. In J-Lat cells, we showed that this synergism was due, at least partially, to the synergistic recruitment of unresponsive cells into the expressing cell population. A combination of prostratin+HDACI synergistically activated the 5' Long Terminal Repeat (5'LTR) from HIV-1 Major group subtypes representing the most prevalent viral genetic forms, as shown by transient transfection reporter assays. Mechanistically, HDACIs increased prostratin-induced DNA-binding activity of nuclear NF-kappaB and degradation of cytoplasmic NF-kappaB inhibitor, IkappaBalpha . Moreover, the combined treatment prostratin+HDACI caused a more pronounced nucleosomal remodeling in the U1 viral promoter region than the treatments with the compounds alone. This more pronounced remodeling correlated with a synergistic reactivation of HIV-1 transcription following the combined treatment prostratin+HDACI, as demonstrated by measuring recruitment of RNA polymerase II to the 5'LTR and both initiated and elongated transcripts. The physiological relevance of the prostratin+HDACI synergism was shown in CD8(+)-depleted peripheral blood mononuclear cells from HAART-treated patients with undetectable viral load. Moreover, this combined treatment reactivated viral replication in resting CD4(+) T cells isolated from similar patients. Our results suggest that combinations of different kinds of proviral activators may have important implications for reducing the size of latent HIV-1 reservoirs in HAART-treated patients. [less ▲]Detailed reference viewed: 72 (9 ULg)
Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated ?
Chau, Tieu-Lan ; Gioia, Romain ; et al
in Trends in Biochemical Sciences - Regular Edition (2008), 33
The IKKs, IKKa and IKKb, and the IKK-related kinases TBK1 and IKKe, play essential roles in innate immunity through signal-induced activation of NF-κB and IRF3/7, respectively. Although the signaling ... [more ▼]
The IKKs, IKKa and IKKb, and the IKK-related kinases TBK1 and IKKe, play essential roles in innate immunity through signal-induced activation of NF-κB and IRF3/7, respectively. Although the signaling events within these pathways have been extensively studied, the mechanisms of IKK and IKK-related complex assembly and activation remain poorly defined. Recent data provide insight into the requirement for scaffold proteins in complex assembly; NEMO coordinates some IKK complexes, whereas TANK, NAP1 or SINTBAD assemble TBK1 and IKKe complexes. The different scaffold proteins undergo similar post-translational modifications, including phosphorylation and non-degradative polyubiquitylation. Moreover, increasing evidence suggests that distinct scaffold proteins assemble IKK and potentially TBK1 and IKKε sub-complexes in a stimulus-specific manner, which might be a mechanism to achieve specificity. [less ▲]Detailed reference viewed: 126 (10 ULg)
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK epsilon-dependent lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
; Gioia, Romain ; Chau, Tieu-Lan et al
in Journal of Biological Chemistry (2007), 282(43), 31131-31146
Type I interferon gene induction relies on IKK-related kinase TBK1 and IKK epsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins ... [more ▼]
Type I interferon gene induction relies on IKK-related kinase TBK1 and IKK epsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins that assemble these kinase complexes are poorly characterized. We show here that TANK/ITRAF is required for the TBK1- and IKK epsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex. Moreover, TANK is dispensable for the early phase of double-stranded RNA-mediated IRF3 phosphorylation. Interestingly, TANK is heavily phosphorylated by TBK1-IKK epsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKK epsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKK epsilon kinase activity. Thus, we have identified TANK as a scaffold protein that assembles some but not all IRF3/7-phosphorylating TBK1-IKK epsilon complexes and demonstrated that these kinases possess two functions, namely the phosphorylation of both IRF3/7 and TANK as well as the recruitment of an E3 ligase for Lys63-linked polyubiquitination of their scaffold protein, TANK. [less ▲]Detailed reference viewed: 73 (18 ULg)
Interacting surface of the receptor-binding domain.
; ; et al
in Société Belge de Biochimie et de Biologie moléculaire. (2002, February 22)Detailed reference viewed: 9 (1 ULg)
A critical cysteine residue of bovine leukemia virus SU protein interacts with zinc and plays a role in viral infectivity.
; ; et al
in The 2001 meeting on Retroviruses. (2001, May)Detailed reference viewed: 15 (2 ULg)
Implication de la protéine transmembranaire d'enveloppe du virus de la leucémie bovine dans la fusion cellulaire et l'infectivité virale.
; ; et al
in Séminaire de la Recherche Télévie (1999, March 16)Detailed reference viewed: 16 (2 ULg)
Mutations in the immunosuppressive peptide of bovine leukema virus affect fusion and infectivity in vivo
; Kettmann, Richard ; et al
in Virus Research (1997), 47(2-Special Issue), 103Detailed reference viewed: 9 (2 ULg)


text:
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text:
Detroit Primary Election Guide 2013
- Written by The Michigan Chronicle
- Published in Detroit
On Tuesday, August 6, 2013 Detroit voters will get the chance to have their voices heard by voting in the primary elections for city mayor, city council and other offices.
Voter's Information:
- Polls open: 7 a.m. to 8 p.m. Tuesday. Anyone in line before the polls close will be allowed to vote.
- Absentee ballots: They are still available at the city's Department of Elections, 2978 W. Grand Blvd., from 8 a.m. to 4 p.m. Monday. Where to vote: Find your polling precinct location here.
- For more info: Call the city's Department of Elections at (313) 876-0190 or visit the department online.
In addition, Detroit Public TV collaborated with the University of Michigan-Dearborn and the League of Women Voters to develop a comprehensive voter guide at MiVotes.org.
Read more http://www.michronicleonline.com/index.php/news-briefs-original/13872-detroit-primary-election-guide-2013


text:
I Wonder What Was Michael's Favorite Books To Read
I have have heard on numerous occassions that Michael was an avid reader. I find that to be a very wonderful and cool thing, because that shows that he was an intelligent man. So me being the literary buff and bookworm that i am, i figure that that i read his favorites. So what was the titles of Michael's favorite books? I know it may sound strange that i would want to read the same books as Michael did.
Comments (36)
Here is a list of some of the books he read. http://rhythmofthetide.com/michael-jacksons-library-favorite-books/
Michael was an extremely intelligent human being. I heard he had a brilliant memory as well. I enjoy reading as well. I love reading biographies about important people in history. I think it's sad that people don't give Michael enough credit. He was capable of many things in his life. Michael loved music but most people don't know he loved classical music. Michael loved to dance but most people don't know he knew how to tap and swing dance. Michael had more intelligence and talent in one finger than most people will ever experience. He should be known as one of the great minds.
Hello jompsl! Glad to share. Your LlNK was to the second artlcle. l couldn't do lt because, as you notlced, there's a problem wlth my "eye" key so l have to get creatlve. l wasn't home when one of my nleces's came by to vlslt along wlth her 2-year old son. She used my laptop but dldn't close lt up and turn lt off when she flnlshed. So of course her LlTTLE MONSTER got on lt and somehow or another he removed the "eye" key from my Sony Valo. l feel that my nlece should replace the key, but so far she hasn't done lt and lt has been a real lnconvenlence because everythlng l type looks strange plus there are a lot of thlngs that l can't do because of the mlsslng key. So l guess l'm golng to have to replace lt myself. Oh well.....
l'm an avld reader myself, and l came across some lnterestlng lnfo regardlng MJ and hls love of books. l read that Mlchael Jackson was "Extremely well-read" and that hls "majestlc" Llbrary at Neverland had 10,000 volumes on lts shelves (the reason they knew how many books there were ls that durlng the 2005 trlal the Santa Barbara DA's offlce had Neverland ralded and searched three tlmes clalmlng that there was evldence hldden ln MJ's home that they needed. The agents went lnto the LlBRARY and took every last one of the books down and went through them all, supposedly searchlng for "CHlLD PORNOGRAPHY." The thlrd tlme they came was unannounced and Mlchael was there wlth hls klds, who wltnessed the rald. lt was after thls unnecessary lntruslon lnto hls PRlVATE LlFE that he sald, "l can't take thls anymore" and he declded to move out of Neverland
l found thls and more ln an artlcle that l had prlnted out and saved qulte some tlme ago. l had come across a reader blog at seattlepl.com entltled "Mlchael Jackson "Extremely Well-Read", Had 10,000 Books". There were also two LlNKS wlthln the blog entry:
1) LA Tlmes artlcle wrltten by staff wrlter Carolyn Kellog dated June 27, 2009 entltled "Mlchael Jackson, the bookworm."
2) LA Weekly artlcle by Randall Roberts dated Thur. June 25, 2009 entltled "Mlchael Jackson's Lawyer, Bob Sanger, Talks to West-Coast Sound About the Pop Star, Hls Llfe---and Hls Readlng Hablts." Durlng a rather lengthy lntervlew Sanger sat ln court wlth MJ every day for four months and got to know hlm and how hls mlnd worked. Mr. Sanger glves the lmpresslon that rather than belng a drugged out zomble as the medla would have us BELlEVE, Mlchael was there and fully engaged. He just gave the appearance that he was not.
Sorry l can't provlde the Llnks due to a problem wlth my laptop, but you can google them. You'll flnd out a lot of lnterestlng and surprlslng facts about Mlchael and you'll come away wlth new found respect and admlratlon for thls wonderful man. l laugh every tlme l thlnk about people who thought they "knew" hlm as "CHlLD-LlKE" and not very brlght. Funny that there ls hardly anythlng wrltten about hls lNTELLlGENCE and how he was able to converse on a wlde varlety of subjects and that more than shopplng for antlques and objects of art, he loved to shop for BOOKS. Probably one reason for hls sadness and LONELlNESS was that lt was dlfflcult to flnd someone (a woman)lntellectually and splrltually equal to hlm. Oh there were many BEAUTlFUL women, but that wasn't what he longed for and needed.
And flnally, he never lost hls CURlOSlTY and THlRST FOR KNOWLEDGE, because hls last home, the one ln HOLMBY HlLLS, had a wood paneled LlBRARY where he no doubt spent lots of tlme.
All book lover will read anything, I ship home 36 book when I was in the USA. A few month ago.
But i am in to ebook too, I just got peter pan ebook and I have a old copie from 1936.
I think MJ would read and collect any and all good books.
And then read them that is what I do.
All book lover will read anything, I ship home 36 book when I was in the USA. A few month ago.
But i am in to ebook too, I just got peter pan ebook and I have a old copie from 1936.
I think MJ would read and collect any and all good books.
And then read them that is what I do.
Michael is a great reader He likes to read a Bible daily , he likes History and interesting people analogy books . I Love to read too specially dancing the dream is my second Bible he is also a good writer . nice thred Tiff thanks so much
tiffany... as i know it was "The Old Man and the Sea a novella by Ernest Hemingway " =)
@MJCUTIEPIE That is a funny pic of Michael reading but am wondering why is he reading that book upside down? LOL
@MJCUTIEPIE That is a funny pic of Michael reading but am wondering why is he reading that book upside down? LOL
He liked reading books on art, poetry, different religions. Here's a few of his favorite books that's listed on the MJ fan club site...
Favorite Books: 'Peter Pan' by James Matthew Barrie, 'Jonathan Livingstone Seagull' by Richard Bach, 'The Old Man And The Sea' by Ernest Hemingway
Yes am going to get the book "They Caged The Animals At Night" . That was a very touching interview that Michael did with the auhor of that book. I also read in an interview that he read numerous books on Walt Disney and the Disney empire. Michael was an amazing man indeed.
One book that I know that he liked is called "They Cage the Animals at Night"
by Jennings Michael Burch. Michael interviewed him on one of the special features of the movie "Miss Castaway." The book is about a boy and his only friend in the world, a stuff animal named Doggie. It is a very touching story. I know that you will like it. Here is a synopsis of the book:
One rainy day in Brooklyn, Jennings Michael Burch's mother, too sick to care for him, left him at an orphanage, saying only, "I'll be right back." She never returned. Shuttled through a series of bleak foster homes and institutions, he never remained in any of them long enough to make a friend. Instead, Jennings clung to a tattered stuffed animal, his sole source of warmth in a frightening world. This is the poignant story of his lost childhood. But it is also the triumphant tale of a little boy who finally gained the courage to reach out for love-and found it waiting for him.
He was also seen reading this book, Animal Language by MIchael Bright. Funny pic!!
Michael was very intelligent. Although he did not officially attend college, he was given an honorary PH.D in Humanities by Fiske University in 1988 at a United Negro College Fund ceremony. Whitney Houston was his date but Liz, Liza and Christie Brinkley attend to support him as well. The UNCF dedicated the Michael Jackson Scholarship Fund in his name in 1986 for all his generous donations. He wanted to make sure that others could afford to learn and become educated. That is the kind of wonderful man that he was. I love him so much.
Deleted, double post
I would have thought he'd be into reading books about ghosts and haunted places.
I red that Michael was interested in everything;he loved to read and even enjoyed perusing the libraries of people he visited.Michael's favorite subject was literature;he was keen on learning and books were the way for a busy man to gain knowledge.
He said he would read anything he could get his hands on. Can't remember which interview that came from. He is well read and quite the bookworm. That makes him even more hot. He is unbelievably special and precious.
history books , science fiction, the bible
I was thinking it may be the Bible. There were reports that he read his Bible everyday. I am sure he read many, many books but to read one every day. I think it may have been the Bible. Just my thoughts.
Hello Tiffany,
Todd Gray wrote this about Michael......
'He especially loved books on Hollywood glamour from the 1930s, richly illustrated children's books, and coffee-table books on photography'.
"Michael Jackson Before He Was King" by Todd Gray
Wow thats amazing Michael was both artistic and good with words.
He said in Moonwalker (I think, some book anyway) that he would write short stories when he went to school and the teacher liked them so much that she would have him read them to the class
And I know that he used to get A's in English and Art in school. That's no surprise though, his artwork is amazing and Dancing the Dream is beautiful.
If michael wouldve went to college i reckon that he wouldve gotten all a's
They say he had tons of books, he loved to read anything.
Wow these are some very interesting books by some wonderful authors. I can tell that Michael had great taste in reading materials. I think thats another thing that me and Michael shared. WE both are very intelligent bookworms that love books.
In one ebony interview he said he read the dictionary, I found this very amusing, always awesome MJ!
It is said that one of his fave authors is Ralph Waldo Emerson.
Hello Tiffany,
I think that it would be safe to assume that one of Michael's favourite books would have been
'Peter Pan' by J.M.Barrie
Yeah, I have also read that he loved History books, and the "They Cage The Animals At NIght"....His body guards have talked about how much he read. That his library had 100s and 100s of books and that they had all been read! Such an intelligent man he was
I remember reading somewhere that his favourite poet was Ralph Waldo Emerson. He wrote a poem called Earth Song which might have inspired Michael's song!
Nice thread Tiffany


text:
November 26, 2014
SULPHUR SPRINGS, Texas (AP) - Three members of singer Willie Nelson's band have been hurt when their bus hit a bridge pillar in East Texas during rainy conditions.
The Texas Department of Public Safety says Nelson was not aboard in the weather-related accident before dawn Saturday on Interstate 30 near Sulphur Springs.
Trooper Sylvia Jennings says seven people were on the westbound bus, including the driver.
Two band members have minor injuries but the third was seriously hurt. Jennings says all three were transported to a Sulphur Springs hospital. Their names and further details on conditions weren't immediately released.
Jennings says the driver was dealing with wet roads and high winds. The bridge sustained minor damage. Traffic was briefly diverted from the accident site about 75 miles northeast of Dallas.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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text:
The three Democratic candidates for state treasurer talked casinos, financial literacy and the state Lottery at a forum Thursday at Stonehill College in Easton.
The pilot of an F-15 jet that crashed this week in remote Virginia mountains was killed, military officials said...
Trying to come up with some positive ideas about the 2015 Red Sox is sketchy exercise.
Watch video of the attorney general and treasurer candidates' political forum sponsored by GateHouse Media, WCVB and the Martin Institute for Law and Society.
Customers filled the aisles of stores in Brockton, West Bridgewater and Raynham on Thursday as Market Basket nation celebrated the return of ousted CEO Arthur T. Demoulas and an end to the six-week walkout that followed his removal.
Photo sent in by a reader. Entries go in the comments. Godspeed:
A six-week standoff between thousands of employees of the New England supermarket chain and management has ended with the news that the beloved former CEO is back in control after buying the entire...
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A company run by former U.S. Rep. William Delahunt is suing the Department of Public Health's commissioner in an effort to get licensed to operate medical marijuana dispensaries in Taunton, Plymouth and Mashpee.Medical...
Our top moments of the week:13. Best Response: In case you were living under a rock, or, you know, watching something else on TV Monday night,
The graduate student will be one of four captains for the Eagles, who begin their season on Saturday afternoon in Foxboro against the University of Massachusetts.
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I live in Montreal and my school is called Gerald McShane. I love doing ballet. My teachers are Ms. Sabrina and Ms. Paquin. My class is 6 (b). I am 12 years old. In my family there is my brother Adam, my mother, my father and me Sofia.


text:
S'pore tech shines at CommunicAsia 2010
Summary: photo At CommunicAsia 2010, local innovations get showcased by Singapore's Agency for Science, Technology and Research (A*Star) and the Infocomm Development Authority.
TOPICS: Networking, Hardware, Mobility, Storage, IT Employment
10 of 10Image
The digital signage detects when a passer-by has fixed his or her attention on the screen using the Web camera located at the top of the screen. The program then detects the age and gender of the audience and displays age and gender-targeted ads. The ad shown here is a shampoo commercial targeted at females.
The technology is currently implemented by Singapore Press Holdings at locations including Far East Square, the demonstrator said, adding that advertisers can benefit by paying only for the ads displayed.
Photo by Liau Yun Qing
Near-field communications (NFC) technology was also demonstrated by IDA at the show. The Apple iPhone used in the demonstration has an NFC-dongle attached. The photo above shows the dongle reading information from the NFC chip--a video of how to make yummy tiramisu is then pushed to the phone. The phone shown in the lower half of the picture is used as a charge card, with the receipt terminal printing out the amount paid.
NFC will not yet be available for the mass market in Singapore because of a lack of infrastructure ranging from NFC-equipped phones to NFC terminals, said the demonstrator. IDA hopes to promote the technology and is now in discussions with telcos and banks.
Photo by Liau Yun Qing
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text: Jimmy LaSalvia and Chris Barron Share This: Print Latest News The End of GOProud When we founded GOProud in 2009 people thought we were nuts. We wanted to provide a strong voice for gay conservatives and their conservative allies. We had this crazy idea that you could have a group that represented gay and straight people that was authentically conservative. We had this crazy idea that maybe there was room for one gay group that would talk about the issues that REALLY impact gay Americans--jobs, the economy, taxes, retirement security, and healthcare--and do some from a strongly conservative place. Jun 8, 2014 9:17 AM PT


text:
We know that earning a degree is an investment in your future.
The RN-BSN program is competitively priced and is a more affordable option than many other RN-BSN programs in the area. Even more valuable? The program is designed so that you can continue to work while attending class.
Credit Hours:
120 total*
$380/credit hour (on-site)**
$410/credit hour (online)**
*MNU requires a minimum of 30 credit hours to graduate. Most RN-BSN students will need only approximately 40-42 hours to graduate. We offer complimentary transcript evaluations to determine how many hours will transfer into MNU.
**Prices effective July 1, 2014 for new starts.
We have different types of payment options available. Total cost, including fees and tuition, will be calculated based on your program, and can be divided into multiple payments.
Group pricing is another option available for students enrolled in a program within Professional & Graduate Studies. Enroll as a group with your co-workers and receive a tuition discount.
Group of 3-5 co-workers = 5% off entire tuition
Group of 6-9 co-workers = 10% off entire tuition
MNU offers a 10% discount to employees of selected healthcare systems who wish to enroll in our program. Please inquire to see if your healthcare system is eligible for this discount.
The RN-BSN program at MidAmerica Nazarene University is approved for the Federal Direct Student Loan Program. Information and applications may be obtained from the Student Financial Services Office at (913) 971-3298 or email@example.com.
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text:
Dow hits record, erasing recession lossesBy BERNARD CONDON
The Associated Press | March 06,2013AP Photo
A board on the floor of the New York Stock Exchange shows the closing number for the Dow Jones industrial average Tuesday setting a record, beating the previous high it set in October 2007.NEW YORK The stock market is back.
Five and a half years after the start of a frightening drop that erased $11 trillion from stock portfolios and made investors despair of ever getting their money back, the Dow Jones industrial average has regained all the losses suffered during the Great Recession and reached a new high. The blue-chip index rose 125.95 points Tuesday and closed at 14,253.77, topping the previous record of 14,164.53 on Oct. 9, 2007, by 89.24 points.
It signals that things are getting back to normal, says Nicolas Colas, chief market strategist at BNY ConvergEx, a brokerage. Unemployment is too high, economic growth too sluggish, but stocks are anticipating improvement.
The new record suggests that investors who did not panic and sell their stocks in the 2008-2009 financial crisis have fully recovered. Those who have reinvested dividends or added to their holdings have done even better. Since bottoming at 6,547.05 on March 9, 2009, the Dow has risen 7,706.72 points, or 118 percent.
The Dow record does not include the impact of inflation. Adjusted for that, the Dow would have to reach 15,502 to match its old record.
The Standard and Poors 500, a broader index, closed at 1,539.79, 25.36 points from its record.
The last time the Dow was this high, George W. Bush still had another year as president, Apple had just sold its first iPhone, and Lehman Brothers was still in business.
But unemployment was also 4.7 percent versus 7.9 percent today, a reminder that stock gains have proved no elixir for the economy.
Still, the Dow high is another sign that the nation is slowly healing after the worst recession since the 1930s. It comes as car sales are at a five-year high, home prices are rising, and U.S. companies continue to report big profits.
The stock gains have helped retirement and brokerage accounts held by many Americans recover. That, in turn, has helped push U.S. household wealth nearly back to its peak before the recession, though many in the middle class are still deep in the hole. Most middle-class wealth is tied up in home values, which are still a third below their peak.
Good economic news Tuesday helped lift stocks. Retail sales in the 17 European countries that use the euro rose faster than expected, Chinas government said it would support ambitious growth targets, and a report showed U.S. service companies grew last month at their fastest pace in a year.
It feels great, says Marty Leclerc, chief investment officer at Barrack Yard Advisors, an investment firm. In early 2009, when stocks were plummeting, it looked like Armageddon was nigh. Its a lot more fun to be in a rising market.
In the depths of the recession four years ago, few investors would have predicted such a fast recovery. Some feared another Great Depression. Banks were collapsing, lending was frozen, world trade was plunging, and stocks were in free fall.
People thought we were going to relive the 1930s, says Robert Buckland, chief global stock strategist at Citigroup. He calls the stock gains since pretty remarkable.
From its peak in October 2007 to its bottom in March 2009, the Dow fell 54 percent. That was far less than the nearly 90 percent drop in the Great Depression but scary nonetheless. There had been 11 previous bear markets since World War II and none had reached 50 percent.
One man who stayed calm and didnt sell was Jay Sachs, 70, a retired computer consultant. In fact, as others scrambled to exit stocks in late 2008, he plunged in more scooping up drug maker Ely Lilly and Co., health-care products giant Johnson & Johnson and food company General Mills.
You have to be greedy when others are fearful, he says, quoting a famous line from billionaire Warren Buffett, who also bought in the panic. Sachs adds, People are still fearful and thats a good sign. Theres room for growth.
He says his portfolio has doubled in value in four years.
As stock rebounds go, this has been an unusually quiet and uncelebrated one. Typically, bull markets are accompanied by rising trading volume, a surge in young companies going public and Internet chatter over hot stocks.
The past four years, none of that has happened.
Adding to the chastened mood is lingering fear among many investors that stock gains can disappear in a flash. Burned by two stock-market crashes in less than a decade, Americans have sold more U.S. stocks than theyve bought the past four years, nearly unprecedented in a bull market since World War II.
In this run-up, nearly all the buying has come from companies repurchasing their own stock in an effort to boost its value. Companies in the S&P 500 have bought $1.5 trillion since the Great Recession began in December 2007.
Dow records are dismissed by some investors as unimportant because the index comprises just 30 stocks. Many professional investors prefer to follow the S&P 500, which, as the name implies, tracks 500 companies. But the Dow has closely followed the ups and downs of its broader rival over the years, and is a good proxy for how big companies are doing.
The S&P 500 is up 128 percent from its March 9, 2009 low, about the same as the Dow.
The Dow record is a victory of sorts for Federal Reserve Chairman Ben Bernanke. Under his aegis, the Fed launched an unprecedented campaign to lift stocks by making their chief rival for investor money bonds less attractive.
Under a program called quantitative easing, the Fed has bought trillions of dollars of bonds to drive their yields down. The idea was that the puny yields would so frustrate investors, theyd have no choice but to shift into stocks. That, in turn, would push up stocks and make people feel wealthier and more willing to spend, helping the economy.
Just as Bernanke had hoped, American household wealth, or assets minus liabilities, has risen, though the gains havent been shared equally.
In the recession, household wealth fell $18.9 trillion, or 28 percent, as the prices of assets like stocks and homes tumbled. But after bottoming in the first quarter of 2009 at $48.5 trillion, wealth rose $16 trillion through the third quarter of last year and was within striking distance of its peak of $67.4 trillion, according to the latest data from the Federal Reserve. Gains since then may have pushed wealth to a new high.
The rich have been the biggest winners of this bull market. Eighty percent of all stocks are held by the wealthiest 10 percent of households.MORE IN National / World BusinessBRUSSELS European Union institutions are piling pressure on Google to change the way it... Full StoryHELSINKI, Finland European Central Bank head Mario Draghi says the euro currency union remains... Full StoryBUCKSPORT, Maine The road to the middle class in Maine might not be paved with paper any longer. Full Story
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Hands-on: LG Optimus 4X HD & LG Optimus 3D Max
LG follows suit in the quad-core race with its flagship LG Optimus 4X HD and beefs up its 3D smartphone portfolio with the Optimus 3D Max. Let's take a quick look, shall we?
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A Way of Life Yoga & Body Works LLC
| Yoga Classes in Madison Wisconsin
|A Way of Life Yoga & Body Works LLC Website
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|Madison, Wisconsin 53719
|Yoga Style: Hatha Yoga
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Group classes in Hatha, Yin & restorative styles. Specialty classes/workshops - Family/Kids Yoga, Yin Yoga, Core Conditioning and more. Specialty offerings include Corporate Yoga, Private/Small Group, and community youth.
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Democratic Congressional hopeful Brendan Mullen was campaigning in South Bend Wednesday talking about his hopes for Indiana's future.
Dozens gathered for his speech, including some special guests. Veterans stood in support behind the candidate. Members from every branch were present.
A veteran himself, Mullen's says he is honored to have their support. He says veterans feel he'll have a Hoosier voice in Washington.
"Right now we are thirsty for folks to have a chance to move our communities and our families forward," says Indiana 2nd District Candidate Brendan Mullen. "The only way to do so is with bipartisanship and moving our communities and families forward without trying to squeeze the air out of each other."
Mullen is running for Congress in Indiana's 2nd Congressional District. He faces Republican Jackie Walorski this November.


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Calvin Johnson is one of the candidates in my Top 5. Matt Bowen
At the midway point of the 2011 NFL season, let's talk about the MVP award. Here are my top five (plus five more that just missed the cut) as we head into the Week 9 schedule.
ICONIt was easy to make Green Bay's Aaron Rodgers my No.1 MVP candidate.
1. Aaron Rodgers, QB, Packers: The Green Bay QB has thrown 20 TD passes and only 3 INTs to lead the Packers to a 7-0 record, but look beyond the numbers with Rodgers. He is the playing the best football in the NFL. And when you break down this offense, I still can't come up with a solid game pan to match the Packers' personnel and the skill set of Rodgers. Blitz-man, zone pressure, Cover 2, etc. Right now, Rodgers is beating every scheme you can throw at him.
2. Fred Jackson, RB, Bills: Take a step back and really look at Chan Gailey's system in Buffalo, because Jackson is the key player in this offense. The RB has posted over 1,000 yards of total offense (721 rushing, 353 receiving) and has 6 TDs to go along with it. Jackson has shown top tier ability to cut back, exploit the second level of the defense and is a tough matchup for a SS/LB in the passing game. Take him out of that offense and we aren't talking about the Bills as a first place team with a 5-2 record.
3. Calvin Jonson, WR, Lions: Why can't we put a WR on the list? In my opinion, the Johnson is the most explosive weapon in the NFL and he forces you to adapt your defensive game plan. The fade route inside of the 10-yard line vs. press-man, the deep dig, the post, 7 (corner route) and double-move vs. Cover 2, etc. Johnson can run the entire route tree, beat man coverage and get on a safety's cushion in the deep half. Through eight games, Johnson has 11 TDs and 47 receptions for 804 yards. However, the key stat from a defensive perspective: Johnson is averaging 17.1 yards per catch for the 6-2 Lions.
4. Tom Brady, QB, Patriots: Rodgers has better numbers this season, but if there is a QB I am going to pick to go win a game for me in the fourth quarter, it is still Brady. The Patriots' QB has thrown 18 TDs and 8 INTs this season along with 2,361 yards. Maybe I do have him too far down my list, but the key with Brady remains the same: if you want to beat him, you better be near perfect from a pressure and coverage standpoint. That will never change.
5. Matt Forte, RB, Bears: How many wins do you give to the Bears without Forte in the lineup? One? Maybe two? The Chicago RB has accounted for almost 50% of the total offense in the Bears' playbook, can run the screen game and has consistently shown the ability to make defenders miss in the open field. 672 yards rushing and 419 yards receiving for the all-purpose back in Chicago. An ideal fit for what Mike Martz wants to see from the RB position--and the numbers are legit.
My next five….
- Frank Gore, RB, 49ers
- Eli Manning, QB, Giants
- Terrell Suggs, OLB, Ravens
- Ben Roethlisberger, QB, Steelers
- Drew Brees, QB, Saints
Follow me on Twitter: @MattBowen41
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Ghost Adventures: Alcatraz Pictures
The guys explore Alcatraz, America's most famous prison, and the Golden Gate Bridge, the site of more than 1,600 suicides, in an attempt to communicate with lost souls.Filed under:
The guys get a private boat ride through the waters of the San Francisco Bay to Alcatraz Island after the tourists have left.
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Fred Hammond Everything To Me Lyrics
Last updated: 08/23/2013 08:34:26 AM
Ooh, ooh, ooh...
(Verse 1)
My future and my history
My freedom and my liberty
My strength my joy
My life, my peace
Oh Lord You're everything to me
(Verse 2)
My flame, my light
My lamp, my heat
Brighten my path to guide my feet
Anoint my head and fill my cup
Oh Lord You're everything to me
Everything to me
Everything to me
Everything to me
When I felt lost and alone
You came and changed my story
On the pages of my life
You have revealed Your glory
Oh Lord You're everything to me
(Verse 3)
My start, my now
My close, my end
The Lover of my soul, my friend
Oh Lord You are my everything
My Father, God
My Lord and King
(Verse 4)
You heal and cause
Life to increase
You are the cure for my disease
My purpose and destiny
Oh Lord You're everything to me
(Repeat Verse 3 & 4)
Everything to me
Thanks to Ashley for submitting Everything To Me Lyrics.
I couldn't help but cry | Reviewer: jthreehill | 8/22/13
each time I listen to this song by fred hammond, I can't help but cry... I mean every single time.
Just humming the melody lines alone does something in me. It's a perfect description of a heart-felt love song.
Awesome lyrics, I must say.. I sing this song whenever I feel God seems so far away. Again, its just a feeling, because He's never far since truelly He's everything to me!
Thank you Fred for blessing me with this song.
Love song from Heaven | Reviewer: Na' | 5/10/13
Awesome. I been dealing with a lot of things all at once, not to metion Mother's day coming up and my MOM and Grandmother are both deceased. I came across this song without seeking. Oh!, but Jesus, knew what I needed. I've been playing it over-and over-and -over. I feel so peaceful and calm. Not to metion, I knew he was everthing to me, My cup runneth over-and over- and over again. I this is printed. I am overwhelmed....
On the Pages of My Life... | Reviewer: Tope James | 6/20/11
...Jesus came and revealed His glory through this song. When I felt lost and alone, Christ Himself comforted me. There is something beyond the ordinary about the lyrics of this song coupled with the vocal delivery and the entire arrangement. Each time I feel like pouring myself before God, I pick up my phone and plug my spirit through my earphones to heaven on the threashold of this life provoking song. I'm yet to recover from the healing this piece of divinely crafted work has done to my worship paradigm.
Everything | Reviewer: Sonya Green | 8/29/08
There are times when I just listen to this song over and over on repeat and I can I feel the manifest presents of the Holy Spirt and it just brings tears to my eyes to just thing about the goodness of the LORD. It helped me through a lonely time in my life where I was reminded that with Jesus we are never alone. I can't discuss my problems and what I am going through with anyone at times b/c it is so personal but Jesus is truely a friend in the time of need. The song hits home. I love Fred Hammonds music. Everything he puts out is Fire!
This is all we need | Reviewer: Anonymous | 6/14/07
Songs rarely encompass God in such a personal way. It's laced with the guidance of His word, the intiamcy of His frienship, yet still being the King of glory.
awesome song | Reviewer: dave omofuma | 6/4/07
fred hammond is the best lyrist the world have ever seen..it only shows how close he is to God..his such an inspiration to me..i hope to see him play live someday..
I dont know | Reviewer: Nthabeleng Mohapi | 9/5/06
I have no Idea what was going in the mind, spirit or head of Fred Hammond when He wrote this song. The only thing I know is the impact it Had on my life.
This song helped me stop looking at God as the one who has everything, but as THE ONE WHO IS EVERYTHING!
Thank you!