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Lenses / Re: 50 F1.4 durabilty question« on: September 10, 2013, 04:33:56 AM »
Originally, I wanted to ask the OP - "Are you wondering if an L lens would allow you to drop it continuously?", but then I remembered about the warning I've got from the "trolling rights watch" (no offense . So, is it the first time you've dropped it?
Yes, it was the first time I dropped that particular lens, and that was from only one metre high onto a wooden floor. It was however the second time I destroyed a 50F1.4 as the first one died with exactly the same problem when a handheld scanner slipped out of my hands and hit it while it was on a camera. I have lots of other lenses (both L and non-L) and never had any issues with those, even though they are used in averse conditions (having people bump into you, backpack on bike, doorframes. tripod failure,...)
So my question was rather than "can I drop it continuously", "Do the L Lenses with internal focussing offer better protection against deformation" Because If I have to baby the 50F1.4 every time I throw it in a backpack, I might as wel save up for the 50 1.2L as i'll end up destroying more 50F1.4's in the end (Now on my third copy of the lens already)
But no offense taken for your original question, it was more about the fact that the particular lens I have is apparently very prone to issues due to the construction (so Next time, I'll replace it tiwth the L anyway)
That makes sense. However, you would throw away a lot more $ if you destroy a 50L . You've said that you love the manual focusing ring, then maybe a pure manual prime is what you need?

subset: commoncrawl


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Sarasota, located along Florida's Gulf of Mexico, is well known for its white sandy beaches and beautiful architecture. Boasting a diverse collection of shops, restaurants and entertainment, coupled with quaint charm, it's easy to see how Sarasota has become known as the place where, "urban amenities meet small-town living."
Consistently ranked one of the top 100 Fine Art Shows by Sunshine Artist Magazine, The Downtown Sarasota Festival of the Arts is one of the area's biggest and best art events. Meet some of the best artists in the nation, displaying life-size sculptures, spectacular paintings, one-of-a-kind jewels, photography and more.
Take I-75 to exit 39 (State Road 780 or Fruitville Road). Exit #210 Go west to Highway 301, make a left, go south for one block to Main Street and make a right.
Navigational Address
1592 Main St.
Sarasota, FL 34236
Use the interactive mapto find up-to-date directions,hotel information, restaurants,atms & much more.


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COLLIER COUNTY, Fla.- Collier County Sheriff's deputies arrested Hector Mateo Sebastian Matias yesterday, after a single-vehicle rollover on Alligator Alley.
The crash happened on I-75 at mile marker 74, when deputies say Sebastian Matias veered off the roadway and into the median for unknown reasons.
Sebastian Matias and the child were transported by ground to Naples Community Hospital, while Dominga Pablo, a 34-year-old pregnant female, was transported by helicopter to Lee Memorial Hospital in critical condition.
According to the Florida Highway Patrol, neither the 3-year-old nor Pablo were wearing their seat belts, and were ejected from the vehicle. The 3-year-old sustained serious injuries.
Sebastian Matias now faces charges for child neglect and driving without a license.


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Eagle Claw Oval Stick Fixed Spring Float 2.5" - $2.49
Traditionally thought of as a technique for targeting pan fish, bobber fishing has evolved into a sophisticated tool for catching bass. Constructed from durable Balsa wood, the Eagle Claw 2.5" Oval Stick Fixed Spring Float makes for a highly visible bite indicator, even in low light or windy conditions. The fixed spring allows for a speedy and secure connection that's super sensitive to bites. A great way to target suspended fish or avoid tangling in areas with heavy cover, the Eagle Claw 2.5" Oval Stick Fixed Spring Float helps take a time tested method into a new era.
No customer feedback has been added yet! Be the first to write something about this product.
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SEATTLE (AP) - Ever since a University of Washington study published in a major medical journal in 2007 showed baby videos don't make infants smarter, the creators of the Baby Einstein series have been battling the university in court and in the media.
Baby Einstein co-founder William Clark is announcing on Thursday what he feels is a victory in this battle. The university has agreed to pay him $175,000 and turn over the original data from the study that discredited baby videos. And Clark says the data he has been given appears to have some problems.
But the university and a researcher involved in the project stand by the study and the data and say if Clark wants to discredit the research, he should do his own study or reanalyze the data.
(Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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Today we finished up a mini-makeover in the kitchen that injected a bit of color and opened up the space.
I am kicking myself for not having a true before picture, but here is the pantry during the planning process :
You can see that I've already picked out a color in this shot. What you don't see is how Mike had taken off the bi-fold door that used to cover the pantry. Removing the door did a tremendous job of opening up our tiny kitchen.
With a few coats of color on the walls and inside trim and a fresh coat of white on the shelves, the mini-transformation was complete.
- one coat of Kilz2 Latex Primer
- two coats of Behr Premium Plus, color: Corn Husk Green, finish: semi-gloss
- two coats of Behr Premium Plus, color: color-matched to Gallery White, finish: hi-gloss
Though we don't prime everything we paint, it seemed especially important to start with a coat of primer because of the grease, grime and odors that can build up in a well-loved kitchen. In addition, there were a couple food stains on the shelves that benefited from the extra stain protection.
Each coat of paint took about three hours, so be prepared for the time required in the pantry. Nearly every surface is an edge that needs to be cut, and many of the angles were awkward to reach.
De-cluttering the top shelf with a few Le Creuset pieces and our stainless steel bowls also helped in keeping an open feel. I re-arranged other parts of the kitchen to make room for the previous top-shelf tenants. We doubly-benefited by pulling out a colorful dot canvas box to hold tea and other hot drinks (now on the top of the refrigerator, and adding a new color element).
What do you think? Are you ready to infuse some color into your kitchen?


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18 of 37 Items
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Real property -- New York (State) -- New York -- Queens (Borough) -- Maps
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Early Real Estate Atlases of New York
Stephen A. Schwarzman Building / The Lionel Pincus and Princess Firyal Map Division
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Manchester United have recalled striker Febian Brandy from his loan spell at Swansea City.
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The 19-year-old secured a second loan move to the Liberty Stadium last summer, and recorded 14 Championship appearances for the Swans this season.
Brandy's deal was due to expire on Saturday but the Red Devils have opted to recall him early.
The diminutive forward will now be unavailable for Swansea's FA Cup third round tie at Histon on Tuesday evening.


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- Chiefs vet Berry has mass in chest | Teicher
- Source: Red Sox to pay Ramirez $88 million
- NFL will mull fine, not suspension, for Raiola
- Source: Seager, Mariners strike $100M deal
- Taylor apologizes, will not appeal NBA ban
- Manziel involved in hotel altercation | Fowler
- Smith: Didn't put Falcons in position to win
- Brown: Blount's strong Patriots return 'great'
- UNC celebration damages Duke locker room
- Agent: Sandoval to sign with Boston | Law
- Joyner: Sneaky NFL fantasy playoff advice
Week 12 Wrap-upGiving thanks to football. Barnwell »
Upon Closer ExaminationNFL winners and losers. Mays »
Cousin Sal. B.S. Report »
NFL's Unsettling Deal
If the NFL's concussion deal is upheld, CTE sufferers lose out. Column »
FiveThirtyEightJames Smith is America's most common name. Flowers »
The case against early cancer detection. Aschwanden »
Sean Farnham
Travis Haney
Neil Hornsby
As expected, Manny Pacquiao beat up Chris Algieri. He, and we, know whom he must fight next. Dan Rafael »
Hockey icon Pat Quinn, who died Sunday night, garnered deep respect and great success. Pierre LeBrun »
That bizarre delay in the Rams-Chargers game added to Week 12's controversy. Kevin Seifert »
Panthers: Feed Benjamin the ball. Newton »
Giants: Beckham Jr. worth watching. Graziano »
Lydia Ko is doing things most teens just don't do. Her double Sunday was unprecedented. Mechelle Voepel »
Look at when, where and with what Lionel Messi scored his 253 goals in La Liga. Graphic » Top goals »
- Weekend Encore: The best sports images
- O'Neil: Old coaching guard still going strong
- Four-Ball: A fine line with Tiger's new coach
- Schoenfield: M's wise to invest in Kyle Seager
- Rankings: Islanders (yes, the Islanders) No. 1
- Okamoto: Edgar on road to rematch with Aldo
- SweetSpot: Issues on this year's HOF ballot
- Adelson: Inside the ACC operations center
- Book excerpt: Chelios was stunned by trade
- Cockcroft: Pats' backfield is still unpredictable
Watch and participate with "SportsNation" TV weekdays on ESPN2 at 3 p.m. ET.
KISS CAMAfter falling into the crowd, the Nuggets' JaVale McGee planted a kiss on the cheek of a surprised fan. Watch »
After a technical glitch at an NHL game, Canadian fans stepped in and helped the singer finish "The Star-Spangled Banner." Check it out »


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Chemist resumes in Pittsburgh, Pennsylvania
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text:
Originally written on The Cardinal Connect | Last updated 11/2/14
With the 2012-13 college basketball season quickly approaching, The Cardinal Connect will provide a brief preseason player profile for all 15 members of the team. We'll take a look at each player's production from last season and provide what their reasonable expectations should be in 2012-13. Peyton Siva, 6-foot-1, PG, Sr. 2011-12 Season Review: As far as the regular season goes, Peyton Siva slightly regressed from sophomore to junior year. With that said, the regular season didn't matter at all after Siva was able to turn it on and play at an elite level the in post season. It didn't get mentioned much until after the season had ended, but Siva played the majority of the season with a minor injury. His performance in the Big Easttournament sparked Louisville's magical post season. In four games Siva averaged13.8 points, 6.3 rebounds, 5.8 assists and 2.8 steals. He was named the most outstanding player of the Big East Tournament. Siva's solid play continued as Louisville entered t...
Original Story: http://www.thecardinalconnect.com/201...
PLAYERS: Peyton Siva
TEAMS: Louisville Cardinals
TEAMS: Louisville Cardinals
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text:
Review The Song (3)
Some of them are hairy, Some of them are bald
Some are kind of scary, And this is what they're called
They call that thing..vagina
Some belong to virgins, They're really tight and strong
But big or small i love em'all
That's why i sing my song!
They call that thing..vagina
Some of them are smelly, Like clams and fish and such
Some smell like a summer's eve cause they've been douched too much
They call that thing..vagina
They call that thing..vagina
Nothing could be finer than to be in a vagina, in the morning
Click here to submit the Corrections of The Vagina Song Lyrics
Please Click Here to Print The Vagina Song Lyrics
I have it on cassette.... | Reviewer: The Captain | 7/18/2007
It is by Pig Vomit, I have the album on cassette, plenty of other good songs on it including "Did you ever wonder?"
Is this review helpful to you? Yes No
Vagina song | Reviewer: oOdudeOo | 6/17/2007
I think its Rodney Carrington who made the song, but im not 100% sure, check it out, it could be him :)
Is this review helpful to you? Yes No
This is NOT the Bloodhound Gang. | Reviewer: dummy accountus | 4/21/2007
"The Vagina Song" is not on the album "Use Your Fingers" by the Bloodhound Gang. I am not 100% sure who actually sings it, but it's not The Bloodhound Gang, Weird Al Yankovic, NoFX, Monty Python, The Longpigs or Voltaire. There is some belief that it is by a band called Pig Vomit, according to http://free.house.cx/~eil/etc/notal_list.html
But I haven't seen any proof myself.
Is this review helpful to you? Yes No
The following area is only for review, if you want to submit the lyrics or the corrections of the lyrics, please click the link at the end of The Vagina Song Lyrics.


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Holistic physician, author & speaker specializing in "super" nutrition, mind-body medicine & green juicing. Eat more Greens! @mrsvirginia2013 @putonthebrakes


text:
Kerry's advice south on whether Russia might accept Boston bomber's body
By MICHAEL SNEED email@example.com May 7, 2013 6:40PM
John Wayne in "Rio Bravo" (1959)
Article Extras
Updated: June 9, 2013 6:37AM
The Boston Strangler. . .
It's grisly.
Finding somewhere to bury the body of alleged Boston Marathon bomber Tamerlan Tsarnaev has taken an unusual turn.
◆ Translation: Sneed hears rumbles that Secretary of State John Kerry's office is being asked to assist and/or give advice on the possibility of Russia accepting the body of Tsarnaev, who was killed in a shootout with the Boston police.
◆ Claim 'em: No cemetery has yet come forward to accept the body for burial, and his American wife refused to claim it, leaving the task to an uncle.
A goofball abroad. . .
A tale of two Rods: Is basketball bad boy Dennis Rodman becoming the new Rod Blagojevich in a goofball effort to save an American hostage?
Capitalizing on his friendship with North Korean strongman Kim Jong Un, Rodman is trying to free American citizen Kenneth Bae, now imprisoned in the country.
◆ Quoth Rodman: "I'm calling on the Supreme Leader of North Korea or as I call him 'Kim,' to do me a solid and cut Kenneth Bae loose," he tweeted Tuesday.
◆ Backshot: Back in 1999, then-Rep. Rod Blagojevich joined the Rev. Jesse Jackson on a successful mission to free three captured American soldiers in Belgrade, Serbia.
The GOP grid. . .
Pssst! Sneed hears a stealth candidate is emerging for leadership of the Illinois Republican Party: Former Illinois Commerce Commission chief Phil O'Connor, who ran successful campaigns for Governors Jim Thompson and Jim Edgar.
◆ To wit: O'Connor, described as the GOP's renaissance man, spent a stint in Afghanistan as an energy consultant rebuilding the country's grid system. "It's hoped he'll be the guy to rebuild the energy of the Republican Party," a top top GOP source said. At last peek, however, Cook County Board Commissioner Tim Schneider appeared to be the front-runner.
Wayne's world. . .
Former Chicagoan Brian Downes, who now heads movie legend John Wayne's museum in the star's birthplace of Winterset, Iowa, tells Sneed that Wayne's 106th birthday this year will be a blowout with Chicago connections.
◆ Translation: Not only will legendary Irish actress Maureen O'Hara — Wayne's romantic partner in "The Quiet Man" and "McLintock!" — be on hand the weekend of May 24 for the celebration, but Chicago's favorite Irish singer, Catherine O'Connell, and our bagpipe buddies the Shannon Rovers will be participating in the extravaganza.
Burke's law. . .
Watch for Ald. Ed Burke, a Roman Catholic, to work at the behest of the Greek Orthodox church as they struggle to get the state Senate to pass a resolution showing solidarity with the church's ability to choose the head of their faith.
◆ Translation: The Greek Orthodox church, whose Ecumenical Patriarchate (akin to the Vatican) is based in Turkey, is forced to bend to the choices made by the Turkish government. The passage of the resolution — sponsored by state Sen. Bill Brady — would add Illinois to a list of 42 states asking for religious freedom for the Greek Orthodox faithful.
◆ Further translation: Burke plans to introduce a motion at Wednesday's City Council meeting urging the state Senate to pass the resolution as soon as possible.
A Martin memo. . .
Femme power: A $250,000 donation to a University of Illinois fund, established by former Congresswoman Lynn Martin to honor distinguished women teachers, has been made by the AT&T board of directors.
◆ Backshot: Martin, who was Labor secretary under President George H.W. Bush, is a former high school teacher. She graduated from U. of I. and is a former member of the AT&T board.
◆ Puckshot: It's not surprising that Martin majored in English. As a member of Martin's gab group of "High Hens," I've been subject to the cluck puck she dispenses when English is used incorrectly.
Sneedlings . . .
Wednesday's birthdays: Enrique Iglesias, 38; David Attenborough, 87, and Lovie Smith, 55.


text: Top Of The World View full-size image < previous next > Is this photo a winner? "Pathfinder Outdoors Sponsored The 7th annual FJ Summit in Ouray CO. Shirts for the event (including our sons) we printed by CI. This Photo was taken at the Summit of Imogene Pass on a dirt trail that breaks 13k feet. This is the highest road In the US and less than .000001% of all drivers will ever drive here. " - http://www.pathfinderoutdoors.com - Pathfinder Outdoors (Aug 05, 2013) Share this photo on: Twitter Facebook Pinterest Similar Photos: FJ Summit 2013 | retail | event sporting | ouray | co | summit of imogene pass | dirt trail Feeling inspired? Visit the CustomInk Design Lab to start your own group order. Design Your Own


text:
Description: Dan St. Paul on the Bob and Tom Show
First baseball game on Bob and Tom Show - Download MP3 music or MP4 video:
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Follow Me On Twitter: https://twitter.com/HmmJesse Most Vids On Youtube Are Missing The Second Half Which Is Hilarious To. First Debuted On Bob & Tom Show.
Comedian Dan St. Paul recreates the first baseball game ever played on the Bob & Tom Show.
From the Bob and Tom Show, according to Dan St. Paul, Harry Caray was the only commentator alive for the first ever baseball game between the Bethlehem Brave...
Bob and Tom classic bit written and performed by Dan St. Paul live at Ventura Comedy Club in Ventura, CA .
Part 2 of Dan St. Paul's "First Baseball Game" with Dan doing Harry Caray on the Bob and Tom Radio Show.
The first baseball game ever to be played - this is how it Really went down!
A funny impression of Harry Carrey on the Bob and Tom show.
Dan St. Paul's Harry Caray broadcasting the Afterlife All-Star Game on the Bob and Tom Radio Show.
This is a sketh from the Bob and Tom Radio Show, in which comedian Dan Saint Paul does a most hilarius impression of Harry Carey who in the skit is doing a l...
Cal stepped up to bases loaded. Smacked a 2 RBI single to right. Falcons Baseball with all his friends from the japanese grade school. Buddhist Church of San...
Andrew's team is Western Guilford HS and they are playing Northeast Guilford HS in this game. The temperature when the game started at 7pm was 38 degrees. No...
Jordyn Lynn makes here debut on the diamond.
Dodger Stadium 5/26/13.
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Latest Updates
We're thrilled to announce that this year's participants have now been selected for the Oxfam-Monash Innovators and South Africa Student Placement Programs. For more information on the South Africa placement program, click here, and for Innovators, click here.
News, Events and Research Updates
- The Sustainable Development Solution Network is proud to launch SDSN.edu – a new flagship educational initiative offering free online courses on sustainable development, created and ... Read more
- The Partnership is pleased to announce that our Annual Report for 2013-2014 is now available for viewing. The report details what has been a fantastic ... Read more
- This Tuesday, the 15th of July, the Monash Asia Institute and Monash Sustainability Institute host 'Migration: From Threat of Climate Change to Adaptation Tool'. The ... Read more
- Women won't be paid as much as men for another 75 years, Oxfam Australia said today in a new report that urges G20 leaders meeting ... Read more
- This month, the work of OMP Research Fellow Larry Stillman has been featured in the latest edition of Monash Magazine, as part of a feature on Monash's work ... Read more
- On Thursday the 15th of May, the OMP launched 'The Futures Series' with a public forum at Federation Square. The event featured a number of prominent ... Read more
- On the 13th of June, the Monash European and EU Centre and Monash Asia Institute will present The Symposium on Food Security – The Global ... Read more
- Marlene is our new intern helping out with communications at the Oxfam-Monash Partnership. She is a student at Monash University currently studying a Masters in ... Read more
- We're thrilled to welcome home the students who took part in this year's South Africa Student Placement Program, after another successful year of the program. ... Read more
- Join us this Friday as OMP Research Fellow Larry Stillman presents 'Mobiles, billboards, flipcharts, and street drama: prospects for an interactive and multimedia community information ... Read more


text:
Trial record 1 of 1 for: NCT 01983683
Previous Study | Return to List | Next Study
Phase 3 Study With Cadazolid in CDAD (AC061A302)
This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2014 by Actelion
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: November 7, 2013
Last updated: November 12, 2014
Last verified: November 2014
- Full Text View
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- How to Read a Study Record
Detailed Description:
Subjects with CDAD are randomized and then treated with study drug for 10 days. At the end of treatment, cure is assessed; subjects are then followed-up to assess any disease recurrence.
Clostridium Difficile Associated Diarrhea
Drug: Cadazolid
Drug: vancomycin
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
|Official Title:
|AC-061A302, A Multi-center, Randomized, Double-blind Study to Compare the Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD).
Resource links provided by NLM:
MedlinePlus related topics: Diarrhea
Drug Information available for: Vancomycin Vancomycin hydrochlorideU.S. FDA Resources
Further study details as provided by Actelion:
Primary Outcome Measures:
- Clinical Cure at End of Treatment [ Time Frame: End of Treatment(10 days after starting study drug) +2days ] [ Designated as safety issue: No ]Resolution of Diarrhea AND No additional CDAD treatment.
Secondary Outcome Measures:
- Sustained Cure [ Time Frame: End of Treatment(10 days after starting study drug) +28-32 days ] [ Designated as safety issue: No ]Clinical Cure AND No Recurrence.
- Time to Resolution of Diarrhea [ Time Frame: Baseline to End of Treatment(10 days after starting study drug) ] [ Designated as safety issue: No ]The time between the first dose of study drug and Resolution of Diarrhea.
- CDAD Symptoms [ Time Frame: Baseline to End of Treamtent(10 days after starting study drug) +2 days ] [ Designated as safety issue: No ]Change from baseline to End of Treatment +2days in CDAD Symptoms as measured by the DaySyms Patient Reported Outcome (PRO).
|Estimated Enrollment:
|Study Start Date:
|November 2013
|Estimated Study Completion Date:
|December 2015
|Estimated Primary Completion Date:
|November 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Vancomycin
Vancomycin 125 mg qid or matching placebo capsules
Drug: vancomycin
Oral vancomycin 125 mg or matching placebo capsules 4 times daily
Other Name: vancomycin
Experimental: Cadazolid
Cadazolid 250 mg bid or matching placebo granules
Drug: Cadazolid
Cadazolid 250 mg or matching placebo oral suspension twice daily.
Other Name: ACT-179811
Detailed Description:
An interventional study to investigate the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-Associated Diarrhea (CDAD).
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Signed Informed Consent.
- Male or female ≥ 18 years of age. Females of childbearing potential must agree to use an adequate and reliable method of contraception.
- Subject with a diagnosis of mild-moderate or severe CDAD (first occurrence or first recurrence within 3 months) with: Diarrhea: a change in bowel habits with > 3 liquid or unformed bowel movements (UBM) within 24 hours prior to randomization, AND Positive C. difficile toxin test on a stool sample produced within 72 hours prior to randomization.
Exclusion Criteria:
- More than one previous episode of CDAD in the 3-month period prior to randomization.
- Evidence of life-threatening or fulminant CDAD.
- Likelihood of death within 72 hours from any cause.
- History of inflammatory colitides, chronic abdominal pain, or chronic diarrhea.
- Antimicrobial treatment active against CDAD administered for > 24 hours except for metronidazole treatment failures (MTF)
- Known hypersensitivity or contraindication to study drugs, oxazolidinones, or quinolones.
- Unable or unwilling to comply with all protocol requirements.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01983683
Show 85 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01983683
|Contact: Global Medical Information
Show 85 Study Locations
Sponsors and Collaborators
|Study Director:
|Paul McGovern, MD
More Information
No publications provided
Keywords provided by Actelion:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on November 27, 2014
No publications provided
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01983683 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 7, 2013
|Last Updated:
|November 12, 2014
|Health Authority:
|Argentina: Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica
Belgium: Federal Agency for Medicinal Products and Health Products
Brazil: National Health Surveillance Agency
Canada: Health Canada
Chile: Instituto de Salud Pública de Chile
Czech Republic: State Institute for Drug Control
Greece: National Organization of Medicines
Hungary: National Institute for Quality and Organizational Development in Healthcare and Medicines
Israel: Ministry of Health
Slovakia: State Institute for Drug Control
Korea: Ministry of Food and Drug Safety
United States: Food and Drug Administration
Keywords provided by Actelion:
Clostridium difficile infection
Post-antibiotic diarrhea
Additional relevant MeSH terms:
Signs and Symptoms
Signs and Symptoms, Digestive
Anti-Bacterial Agents
Anti-Infective Agents
Pharmacologic Actions
Therapeutic Uses
ClinicalTrials.gov processed this record on November 27, 2014


text:
Wright takes over Midsomer as True-May exits
All3Media has turned to former BBC and Talkback drama exec Jo Wright to take over from Midsomer Murders co-creator Brian True-May as the show's producer.
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Several plunge into chilly water at Rexburg Snow Fest
Saturday around 100 people descended on Smith Park in Rexburg for the annual Snow Fest.
Even though there was less snow than in past years, those who came out still found ways to make the most of it.
"Sled hills are more ice than snow. Looking early December it looked pretty promising we'd have a lot of snow out here, but everybody knows we haven't gotten it," said Snow Fest organizer Bob Yeatman.
There was still plenty to do, including ice fishing, sledding and taking horse-drawn carriage rides.
"Try to get people out in the good old winter. Enjoy our polar winters. Get them out of the house for a day and have some fun," said Yeatman.
The Ricks family say they visit the Snow Fest each year.
"We have four kids and it's free. We just wanted an excuse to get our kids out in the cold," said Krystle Ricks.
The biggest attraction was the Polar Bear Plunge. Plungers loaded onto a machine before plunging into 38-degree water.
"We let them get in the pool and then there's a hot tub we got right here they get into to warm themselves right back up," said Yeatman.
Daniel Mansky, a foreign exchange student from Germany, said he didn't want to pass up his opportunity to take the plunge.
"It's very cold, yes. But the coldest part is waiting for--being up there and jumping in," Mansky said.
Participants in the Polar Bear Plunge were required to sign waivers in which they acknowledged the exposure to cold water could lead to lack of consciousness, hypothermia and heart attacks. Not everyone thought it was worth it.
"I don't need to prove my manliness to get in some really cold water," said Barry Ricks.
The city-sponsored event was free to everyone.
Copyright 2014 NPG of Idaho. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
- [Photos] Welbeck Poses In Arsenal Shirt After Completing £16m Move From Man Utd
- [Photos] Lazar Markovic Poses In Liverpool Kit After Completing €25m Move
- Chelsea Confirm Signing Of €40m Costa On Five-Year Contract
- [Photo] Fabregas Poses In Chelsea Shirt After Sealing Move + Confirms Arsenal Snub
- Agent Confirms Talks With Arsenal + Man Utd Over €37m Ace
- Chelsea Agree €40m Deal For Spanish Hot-Shot
Arsenal Lining Up Summer Move For French Midfield Enforcer
Despite the transfer window now being closed there will still be plenty of gossip doing the rounds in the newspapers, so we'll keep you up-to-date with the latest transfer rumours. Today, Arsenal are linked with Capoue.
Arsenal boss Arsene Wenger is already planning for the summer and is lining up another bid for Toulouse midfielder Etienne Capoue, according to the Telegraph.
We were strongly linked with the France midfielder during the January transfer window and were reported to have failed with a late bid to land the 24-year-old on deadline day.
The Telegraph claim that despite the knock-back, the boss retains a strong interest in the player after having him scouted extensively in recent months and will make another attempt to sign him in the summer when he looks to bring in a defensive midfielder.
The fact is we never really replaced Alex Song after he left for Barcelona last summer. Mikel Arteta has been largely used as the 'defensive' midfielder this season but I think it's important we bring in a powerful and athletic ball-winner in the summer and Capoue would fit the bill nicely.
Read more Arsenal transfer news
The Telegraph also claim Arsenal will have around £70m to spend in the summer due to the up-front payment we'll receive from the new Emirates sponsorship deal and as well as a midfielder enforcer, Arsene plans to bring in a new striker.
While I feel we should have gone the extra mile at signed a defensive midfielder and a striker in January to help with our push for a top-four finish, at least it sounds like Wenger is going to address things in the summer.
Who would you like the boss to sign in the summer? Get involved in the comments section below.


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Using precooked bacon and presliced mushrooms gets this gourmet fare to the table fast.
Oxmoor House JUNE 2007
Reheat bacon according to package directions until crisp; coarsely crumble. Sauté onion in butter in a large skillet over medium heat 5 minutes until beginning to brown. Stir in garlic, mushrooms, and 3/4 tsp. salt. Sauté 10 minutes or until mushrooms are tender and liquid evaporates. Stir in bacon, parsley, and 1/8 tsp. pepper.
While mushrooms cook, sprinkle both sides of steaks with remaining 1 tsp. salt and 1/2 tsp. pepper.
Broil 5 1/2" from heat 7 minutes on each side or until desired degree of doneness. Let stand 5 minutes before slicing. Cut steaks into thin slices; arrange on a serving platter, and top with mushrooms.
Go to Full Version of


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By Helen Pask -
21 August 2007 09:37
Tim Reeves has taken his third consecutive Superside World Sidecar title after taking the win and a third place in the penultimate round of the series in Croatia on Sunday.
Going into the weekend's races Team Eastern Airways rider Tim Reeves was leading the series by 25 points ahead of the Finnish pairing of Pekka Paivarinta and Timo Karttiala and, after winning his heat in the match race went on to take the victory in the final, crossing the finish line just two tenths of a second ahead of the Fins setting a new lap record of 1m 30.802 seconds.
The record had stood for over 10 years and it was always said that a four-stroke machine would not be able to match the speed of a two- stroke – but this theory has now been proved wrong as Tim Reeves shaved a full second from the existing record with his LCR 1000cc four-stroke Suzuki.
Sunday morning saw the temperature soar to 33 degrees with a track temperature of 50 for the start of the 20-lap Gold race. Tyre choice was a nightmare as the searing heat was to affect the performance and most teams opted for the hardest compound tyre they could lay their hands on.
As the race got underway Tim Reeves remained in third place for the first two laps before forging ahead of Paivarinta to slot into second behind race leader Sebastian Delannoy.
By lap seven Tim Reeves had taken control at the front but was unable to shake off Sebastian Delannoy and Paivarinta. The three outfits were all circulating together as one but were homing in fast on the back markers who could affect the outcome.
The three negotiated the backmarkers without mishap but tyre wear was beginning to come into play with all three outfits sliding off line. By lap 16 Sebastian Delannoy began to fade leaving Paivarinta and Tim Reeves locked in battle at the front. Paivarinta took the lead but on the last lap there was a coming together between the two leaders resulting in Tim Reeves losing his wheel arch and Paivarinta his nose cone.
Both outfits continued to the final corner when Paivarinta bumped the back of Tim Reeves' outfit and ran off the track.
Tim Reeves crossed the finish line to take the win followed by Sebastian Delannoy and the Birchall Brothers. But a protest was lodged and upheld resulting in a 20 second penalty for Tim Reeves, which dropped him down to third place behind new race winner Sebastian Delannoy and second place team Ben and Tom Birchall.
"There were two incidents on that last lap," said Reeves. "I had been following Paivarinta closely and was right on his back wheel as we approached the fast lefthander and then the right turn. He went towards the left and left a gap wide enough to drive a lorry through which seemed to me like a written invitation to overtake. But then he turned back in on me and took my wheel arch off and also his nose cone.
"Although both outfits were damaged we were able to continue towards the final corner. But he ran into the back of me causing his fairing to tuck under the front wheel and he ran off leaving me to complete the race for the win.
"But when we got back to the paddock Paivarinta lodged a protest and the jury upheld it. We intend to appeal and are currently gathering some witness reports to back up our case."
Tim Reeves now heads the table by 210 points to Paivarinta's 164, a lead of 46 points and with only 25 points available to the winner of the final round at Le Mans on September 9 Reeves cannot be beaten and will lift his third successive world championship trophy.
This will be the first world title for passenger Patrick Farrance and he said: "It has always been my dream to become world champion and today my dream has come true. I want to thank Tim and all the team and everyone who has helped us."
Tim Reeves added: "I would like to thank all our sponsors and the team for their continued support this year, without them we would have been unable to be in this position."
Meanwhile Eastern Airways teammates Sean and Mark Hegarty from Felixstowe rode to a strong fifth place in the match race final and were lying in fifth place in the Gold race on Sunday when they were forced to pull in with an oil leak.
"That was a shame, " said Sean. "We were gaining ground fast on the outfit ahead of us and were looking at a good finish. But on further inspection we discovered a damaged crank case was the cause of the oil leak and we had to pull off on safety grounds."
The Hegarty Brothers are currently lying in seventh place on 72 points with one race remaining.
The final round of the 2007 FIM Superside World Sidecar Championship is to be held at Le Mans on September 9 where Tim Reeves and Patrick will be crowned world champions.
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14 February 2007
World Sidecars have clinched a championship round at Brands Hatch – sharing the billing with the DTM, the European-based touring car series.
The meeting on June 10/11 gives...
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Other than the fact that it goes on a little thick, there's nothing bad that I can say about this. Does the job, and I can use it on my face without irritation if need be. It's the only sunscreen I'll use.
I have finally found a sunblock I can use on my face! I never like the smell and the feel of sunblock on my skin esp. my face until I found this. It's very lightweight, non sticky, no white mask-like layer on my face.
Update: This product uses chemical sunscreen avobenzone which I am quite comfortable using for health reasons.
I really wanted to like this because it's a great price for its size and especially because CVS is having a 30% off sale (online) on all sun products! Alas, this irritated my somewhat sensitive skin.
I had no problems using the SPF 30 version of this SS (I used an entire bottle last year - took me 8 months so I probably didn't use the recommended 1 T. amt every day) but I don't know if it's something to do with the ingredients but this STUNG my face when I applied it to bare skin! It didn't really make my face red but it was very uncomfortable and I haven't even dared try to put this onto bare skin again.
I tried to use this on top of moisturizer but it still stung my face. Although it has the best finish I've ever tried (LRP Ultra Light SS Fluid was NOT matte at all for me), it's just too irritating.
I say to myself also why such bad reviews and like others this this is officially now my HG sunblock ....I rarely use anything from neutrogena but from the MUA reviews i decided to give this a try since im trying to heal my acne scars and noticed how the sun exposure only make my acne scars more red and scarry lol... but newho i love how it absorbs into my skin leaving a matte finish. I love the smell that's the smelll sunscreen suppose to have neways for all you who say it smells ... I love how this doesnt leave a white film on ur face b/c i really massage it in well to take out the whiteness... My skin overall has improved due to this thanks mua
I received a sample of this as an extra in a swap - I love it! This rivals and maybe even surpasses my Eucerin Extra Protective Face Lotion simply because it has more spf and provides more of a matte finish, and it works well under makeup. The formula is creamy and thick, and a little goes a long way. The only complaint I have is that the scent, while not unpleasant, is pretty strong. But I will still probably purchase the large size of this product when I run out.
it doesnt clog my pores
it DOESNT make me BREAKOUT
has lots of SPF dats sooo good
i will soooo buy more when im done
This was another Dollar General find. I mix this with my Bioelements moisturizer since it doesn't have any SPF. If I'm not careful, I can put on too much and it leaves a white film. I haven't tested this under makeup yet because I don't wear makeup often.
The product doesn't clog or leave a flim when I use it correctly and i haven't experienced any clogging or burning as other reviews have, but I have noticed that my friends with dry skin haaaaate this stuff on their faces. It causes burning and irritation, so be careful if you have dry skin.
I wish it had a flip cap as aopposed to a removeable one, but it's not a huge deal in the long run.
I really hate this sunscreen. I use it for my body and both times I have applied it, it leaves a white film that gets all over my clothes. It just doesn't soak in! Today I have a black skirt on (I am heading out for a mid-day walk) and the bottom half of it now has a whitish cast that is impossible to wipe off. Do yourself (and your clothes) a big favor and don't but this product.
UPDATE: I even hate it more than before (one hour later.) I just went for a walk during my lunch break (it is really hot) and now my leather chair is full of white film and it is getting all over my clothes. I just threw it out. This is the worst stuff ever.
I'm surprised at many of the negative reviews on here. I have combination/normal skin, and for me, this sunscreen is awesome. It is a physical sunscreen (so it shouldn't be irritating...that's weird some said it was), has super-high spf, doesn't clog pores, doesn't cause breakouts, doesn't smell really bad, and best of all has a great feel. It leaves your skin soft and matte. You could totally apply makeup over-top. It's also not too expensive. I would only use it for your face, though. I found that the matte action felt bizarre on my body.
Love it. OMG! I am so loving this ultra sheer dry-tough sunblock SPF 55 with Helioplex. I was using Sonya Dakar 360 for the few years was tired of spending a fortune on sunscreen and having to order it online. Also, by the end of the day my skin was super greasy. My aesthetician recommended that I try the Neutrogena with Helioplex and boy and I glad I did. I wear this every single day on my face. I'm glad it offers UVA and UVB protection. I'm a LLL and I have a lot of freckles. It's light and soaks right into my skin. The scent is very subtle and it's fresh. I really like the scent! It doesn't leave me greasy and even at the end of a hot day, I'm still not shiny. I'm very active, and whether I'm doing Pilates, Yoga, spinning, or running, I can wear this and sweat. It doesn't turn white (Hello Coppertone Sport) and It never EVER burns my eyes. Layers very nicely under my makeup. I actually find it to be a better primer than MAC Prep + Prime 50. The best thing, it's easy to find and you can't beat the price.
1 out of 1 people found this review helpful. Did you? Yes No


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Dispatches From The Road, México: DF Turkey Trot
In November 2005, after having lived in Mexico […]
Giving Thanks for Cheap Wine (and Other Important Stuff)
Broke-Ass Giveaway: 2 FREE Tickets for Messiah…Refreshed! at Lincoln Center on Nov. 25th
We have a great Thanksgiving gift for all of our loyal readers! But first… Distinguished Concerts International New York is ushering in the holiday season this year at
How to Survive Holiday Hype
Alternative Takes on Black Friday
Ok - let's face it, who really enjoys the shit show people go through on Black Friday? I for one, absolutely hate it. Maybe that makes me a
A Broke-Ass Mom Is Thankful For…
Broke-Ass Pop Culture: Thanksgiving Cliches
First of all, I hope you all had a super Thanksgiving. And if you're waiting in the checkout line with a cart full of Black Friday
Robyn O'Neil's "HELL" – FREE Exhibit
Broke-Ass Kitchen,Thanksgiving Edition
Break out the sweatpants and the boxed wine, it's Thanksgiving time, ya'll! (OK, I also feel it's appropriate to do this on any given evening during


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3. Take action that is appropriate to the type of attribute and the purpose of different types of limits.
The action that should be taken when a quality attribute exceeds its specifications is not the same as the action that should
be taken when an attribute exceeds its control limits. Exceeding a specification signals that the product may not be fit for
use, while exceeding a control limit signals that the process may not be in adequate control and should be monitored for shifts
and trends.
4. Treat post-marketing stability studies as a control strategy for the process, rather than an assessment of the lot's stability.
Annual post-licensure stability studies should be designed to monitor stability characteristics of the product, such as changes
in a quality attribute, rather than the level of the quality attribute at points throughout shelf life.
The evaluation of a pharmaceutical products does not end with its approval for marketing. After marketing, sponsors monitor
their products to ensure that they conform to their experience during development. The US Food and Drug Administration generally
requires a commitment to monitor the stability of at least one lot of each approved product produced each year. This approach
to ensuring post-licensure stability could potentially be enhanced to provide increased confidence that the manufacturer produces
product that is safe and efficacious until its expiry. This must be balanced, however, against the risk of a program that
would yield false signals of product instability, resulting in unnecessary effort on the part of industry and regulatory agencies
to ascertain the cause.
The industry and regulators may wish to consider novel models that combine strategic design and analysis for monitoring post-licensure
stability to detect meaningful changes in the stability profile of the product. These models require a shift from the historical post-licensure stability paradigm of requiring that individual stability time-point measurements
meet expiry specifications to a new approach of stability monitoring in which common statistical techniques are used to evaluate
the composite data representing product on the market. A standard regression analysis can be used either to obtain slopes
that can be monitored for shifts or trends in the stability characteristics of the product, or to model ongoing lots for shelf-life
characteristics such as predicted potency at expiry.17
Such a paradigm of stability monitoring promotes data collection. When the data are analyzed using regression analysis, the
inclusion of additional time points or lots provides a more precise estimate of product stability, with less risk to the customer
and manufacturer alike. In contrast, when time-point results are held to specifications, there is an increased risk of "failure"
because of repeat testing, and thus a disincentive for data collection.
The following summarizes the potential opportunities that can result from the design, analysis, and interpretation of annual
stability studies that promote data collection to achieve better control of product on the market:
One or more commercial lots may be enrolled into the post-licensure stability program. A single lot may be used if product
is stable, or if there is an adequate range between product release and predicted value at expiry. More lots might be enrolled
when there is greater risk that commercial lots may fall below their specification limit at expiry.
Standard stability time points, as described in regulatory guidelines, need not be used, if this approach is balanced against
the total number of lots on stability. Studying more lots with fewer time points per lot provides a more representative profile
of product on the market than studying more time points on a single lot.
Data from a single lot, or from all lots currently on stability, might be analyzed using common statistical analysis techniques.
The predicted value from such an analysis will yield a better estimate of the true value of a lot over time than an individual
stability time point measurement will, and the combined analysis from lots on stability provide a reliable forecast of the
quality of product on the market.
The annual stability program might come to be recognized as "quality control on the product," rather than a study of the particular
lots on stability. In this manner, the annual stability program becomes a part of the overall product quality system.
5. Use statistical approaches, where possible, to enhance the design of a study and to obtain reliable product understanding.
Quality by Design (QbD) means that product and process performance characteristics are scientifically designed to meet specific
objectives, not merely empirically derived from performance of test batches. Statistical methods should be used to enhance
the design of manufacturing experiments and to make optimal use of the experimental information.
Multifactor design of experiments (DoE) can be used to identify parameters that affect the process or to define the design
space for the process. Proper analysis of the data provides scientific understanding and empirical confirmation of the process.
Mathematical modeling of the factor responses helps reveal process parameters that affect a critical quality attribute, and
thereby offers a basis for maintaining product quality. Such modeling provides more value than evaluating conformance lots
against specifications.
Likewise, stability studies should be designed to meet the goal of the evaluation. Typically, the goal of the stability study
is to estimate the quality attribute at significant points in time (e.g., at expiry) or the degradation rate at meaningful
temperatures. In these cases, the study should be designed and analyzed to obtain the most reliable (i.e., least variable)
estimate of the parameter of interest. A study to predict the quality attribute at significant points in time will select
intervals that adequately represent the targeted region and will use common statistical methods to forecast response. A study
of the effect of temperature or physical exposure might ideally compare results only at the beginning and end of the exposure
to obtain the most reliable estimate of the effect. These goals, as well as those of validation, are best met using simple
statistical methods rather than comparing results to specifications. Holding stability and validation results to specifications
engenders a disincentive for collecting valuable product and process information.
Senior Director, nonclinical statistics, at Merck Research Laboratories, Merck & Co.
Articles by Timothy Schofield
Scientific Director of analytical and formulation sciences at Amgen Inc.
Articles by Izydor Apostol, PhD
Vice President, quality and compliance biopharmaceuticals, at Boehringer Ingelheim Pharma
GmbH & Co. KG
Articles by Gerhard Koeller, PhD
Biotech quality technology leader at Wyeth Pharmaceuticals
Articles by Susan Powers, PhD
Associate Director, regulatory affairs biopharm CMC, at GlaxoSmithKline
Articles by Mary Stawicki
Director and team leader, biopharma operations, at Pfizer Global Manufacturing
Articles by Richard A. Wolfe, PhD


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Searching for photos of amazing ballpark food is like a self-inflicted wound. At the end of it all, I'm overwhelmed with the pain I've caused myself. Thanks to everyone's inclination to take pictures of food they eat, here's an ode to great ballpark food. (With one caveat: no hotdogs. That's a whole ... More >>
Starring Stephan Pyles, John Tesar, Katherine Clapner, Kent Rathbun, Teiichi Sakurai and a dozen other local chefs.


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A true Jerk. If you want to have a villain who defies all laws of villainry (like speaking in a crass voice, laughing like an idiot) then you have knocked at the wrong door. THIS DOUCHEBAG IS A BLOT ON THE NAME OF CONVENTIONAL VILLAIN. But this bastard is so evil, his douchebaggery has no bounds. Kill your subordinate, your lover, your seniors...May god damn him. Being sealed by Urahara...SERVES YOU DAMN RIGHT, IDIOT.
Why is this fucktard so popular? He's not only one of the worst written villains in history, he also became the most embarrassing anime character ever and went through so many stupid and ridiculous transformations in the end, after beeing cool and quite interesting the whole time before!
BEST ANIME VILLAIN EVEEERRR!!!!! Too bad he showed his true colors as a Butterfly Kami xD
People hate Aizen because he lies, tricks, kills and gives people the wrong idea. I knew he was going to be bad news the first moment I saw him in the episode he first appeared in.
Find it hard that people hate him. I have always used this to rate characters I love and hate the design of. If I am meant to hate a character on a personal level and I do then that character was well designed. Also Aizen is about the only reason I watched bleach past episode 100 if he wasn't so badass I'd have given up way earlier (which I wish I did after they ended it in such a horrible horrible way)
If you liked or , you'd like the other because...


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Is there a rumor you've heard that you would like to track down? Is there something in the community that needs to get fixed? Mary Malahy explains some of the mysteries of life in the Tosa area.
Grassy area in Village isn't too impressive
Issue: A few readers have written to me about the open area in the Village between Harwood and Wauwatosa avenues, noting that the grass is brown there and that the area could use some improvement.
Status: Kathy Ehley, executive director for the Village Business Improvement District, explained that maintaining this area is difficult because there is no water source nearby.
Further, the dirt is only 1½ inches deep. Debris from road construction in the 1970s lies underneath, she said.
These conditions make it difficult for grass or other plants to grow there. Ehley said she spent an entire summer trying to get the grass there to grow - watering it three times a day - but was unsuccessful. She has planted flowers, but they get pulled out, she added. This past summer the BID installed benches and waste receptacles there, and people seem to be enjoying them, Ehley said.
"We want it to be a useful green space, but it really needs to be embraced by the community," Ehley said.
Residents who are interested in helping can join the Wauwatosa Beautification Committee, a volunteer organization that works to improve Wauwatosa's appearance. Visit wbc-wi.org for information.
The city's master plan does not have a definite goal for this area. More discussion needs to happen due to the complexity of the area, Ehley said.
"There rarely is a simple solution if you really look at the ramifications from any changes," Ehley said.
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- Ask Now: What is happening with developments near the intersection of Mayfair Road and Burleigh Street?
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- Wauwatosa Ask Now: Why don't public and parochial schools have the same schedules?
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- Ask Now: Is the size and placement of political signs regulated?
- Wauwatosa Ask Now: Why is construction on Mayfair Road taking so long?
- Wauwatosa Ask Now: Why are the basins in the County Ground never filled with water?
- Ask Now: How to stop medical center employees from smoking on nearby streets
- Ask Now: Why is Pocket Park in such tough shape?
- Ask NOW: Will "The 2100?" ever be built?
- Ask Now: July 3
- Ask Now: Will Wauwatosa develop more recreational land at Hart Park and along the Menomonee River?
- Ask Now: How will Mayfair accommodate parking with its expansion?
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text: Can Romney Win? 'Happy Days' Star Scott Baio Thinks So Print article Send a Tip by Zachary Leeman 16 Oct 2012 post a comment Scott Baio of "Happy Days" fame recently sat down with Fox News to discuss his new sitcom "See Dad Run," and he ended up sharing his thoughts about being Republican in Hollywood and next month's presidential election. After being asked whether he thinks Romney is going to win the election, Baio replied simply, "Sure I do." Baio also spoke of being a part of the small minority of registered Republicans in Hollywood. He believes the community is much larger than people think. They're just not as vocal as their liberal counterparts like Alec Baldwin. "The people who believe what I believe are much quieter about it," Baio said, "I think it's because it's who we are as people. We are less vocal people about what we believe and think." Baio also had some nostalgic thoughts when remembering a candidate he campaigned for many years ago: none other than Ronald Reagan. "When he passed away I wanted to go pay my respects. A producer A.C. Lyles for Paramount, he's worked there for I think 80 years. He was very friendly with the Reagans and I called him and said that I wanted to go. He said, 'Why don't you write a letter to Mrs. Reagan?' So I wrote a letter and faxed it over and she said, 'We'd love to have you,'" Baio recalls. It appears the pool of conservative artists grows deeper with the addition of the clearly grounded and respectable Baio. "See Dad Run" airsat 8 p.m. EST Sunday nights on Nickelodeon.


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Weather Links
Humidity 86%
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Sponsored by: Arceneaux Ford
Humidity 86%
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Dec 11, 2013 1:04 PM by MELISSA CANONE
An official donation site has been set up for a New Iberia family that lost everything in a fire on December 9, 2013. This group effort for the Alexander family has been set to help them recover from this tragic incident. The homeowner also ran a daycare from her residence.
If you would like to help them out call 337-256-0053 or 337-315-2777. You can also drop off items to the official donation site located at 915 E. Pershing Street in New Iberia.
5 hours ago


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This makes sense, when you take a moment to contemplate how lovely autonomy can make you feel – and how miserable its absence can make you.
The Disconnect
As reliably as autumn brings Orion to the night sky, spring each year sends a curious constellation to the multiplex.
Documentaries about punk music often have a political element. But that political element sometimes seems rather contrived.
What is your definition of living life to the fullest?
Austin Icon Leslie is Leaving Town
Leslie, who is about 60, is "arguably the most locally famous street person in Austin" according to his Wikipedia page.
China Laces Up Its Chuck Taylors
Young people with an artistic sense prefer Converse.
Nobody can go back and start a new beginning, but anyone can start today and make a new ending.
In the modeling industry, size 8-10 is the "plus size" range, which is crazy when you consider that Miller is an average (or even slightly below-average) sized woman.
The Life of a Monk… (interview)
In a recent trip to San Antonio, I had the chance to interview a Monk.
Women with sexy eyes in Saudi Arabia may be forced to cover them up.


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Microsoft at a loss in Word patent case?
Time to take a breath following the "landmark" injunction against Microsoft over alleged infringement of an XML patent in Word. Never mind a US jury has found that Microsoft willfully violated an XML patent in its ubiquitous Word application and the case judge fined the company $200m. Microsoft's no stranger to patent …
cocaine is a helluva drug
Wait a min did Rick James write this article.....
"And on a larger scale, it's likely this is the end for Word for Microsoft, its partners, or millions of users."
"This i4i ruling is not the end of the Word or the lucrative Office franchises. "
At a loss
There was a great opportunity for a "Lost for Word" pun here.
I wonder if...
I wonder if this will hurt microsofts plans to get its document format as an industry standard?
I don't think the judge ruled based on the patent case
I think the judge has had to use MS Word 2007 and took this opportunity to try and kill the damn thing whilst he (/she) had the chance....
the end of "word"
You mean something besides the garbage that IS MS Word might kill off MS Word first?
I doubt that the courts will be that fast. What is Word 2007/2008 is such a steaming pile - and it is worse than 2003/2004..... So with the next release, I expect Word to be completely bolloxed.
PH because she has a much better interface.
Perhaps now they'll campaign for software to be excluded from patents? Didn't think so.
Software Patents - Bad!
This is yet another example of why all software patents should not exist. They stifle advances in software development.
What makes the Canadians think anybody here will care?
How do they even have any standing in a Texas court. Let alone the public opinion of a Canadian company trying to battle it out with an American company. Where are our pro-American Texans to set them straight? In a place like that, I'd expect to see the judge personally telling them to go back up to Cannuckland and leave our American software products alone. With all my ranting aside, there should be a limitation on patent claims so the plaintiffs can't wait 6 years after billions of dollars worth of product are sold to step in and say "wait a minute...that's our technology." I'd say if they didn't file this suit by 2004 (more than a year after Word 2003 came out), they shouldn't even be allowed to complain, let alone sue over it.
This would mean
No more MS Office in the USA?
Paris because she prefers Open Office anyways
Never mind Microsoft...
...just tell me if this is likely to impact OpenOffice at all.
Wait, what?
It's early so I may have misread that, but have they patented the X in XML? Because if you can't customise it it ain't eXtensible.
who owns the patent for custom HTML ??? They're sitting on a potential goldmine for the dumbass American legal system!
The patent office that granted this one should be investigated. It is so generic! This could be a problem for FOSS too, as well as the hundreds of products that rely on XML in this way.
It's about time Microsoft got punished for their arrogant failings. Problem is, as always, they'll probably buy themselves out of this one.
Do I still get two more wishes?
The real issue...
..is that this case shows up just show damned stupid software patents are. Ignoring the rights or the wrongs of the judge's decision this case shows that the US patent system is broken. MS have lots of software patents, and just got one for some of the XML manipulation that lies at the heart of the OOXML ISO standard. Many, if not all of these patents should never have been granted.
Microsoft and other large American companies are trying to persuade the EU to embrace software patents claiming that software patents encourage innovation.
I hope that this latest farce, and that is what it is, is enough to make people in the UK and EU realise that software patents are just wrong. If people don't stop the EU changing the law then expect to see this sort of waste of everyone's time and money happening in a court room near you.
Will Microsoft never learn to use open standards?
Will Microsoft ever learn that they don't own the world's computers, and can't just take what they want?
This is only a legal ruling. It won't have much effect.
Normal application of XML
Not knowing the exact details, this 'custom XML' sounds like a normal application of XML Schema with processing in the application. I don't see how this is patentable, or such.
As usual with software patents..
Nobody seems able to report what the patent entails.
Custom XML? Does that mean invalid XML with additional MS features, incompatible with competing products? Or use of valid XML to describe a word processor document?
Is there any chance that the same patent would apply to similar products?
But above all: Who the &*($^ are i4i and what great technological discovery (assuming it's not just using XML to describe arbitrary data, which is what XML is for in the first place) have they been allowed to patent?
Buy it?
Can a patent be bought?
(I'd have thought so - it's just another commodity)
On the other hand if the motivation is mischievous/malicious can MS request some review to protect itself, shareholders, customers, retailers, distributors, ... from effect and consequence of malicious actions?
No great hardship then
"Cannot sell or import..." So licensing and exporting like they've been doing till now are both still okay then?
You mean they are at a loss for Words?
Too bad
If they cant sell Word, theyll have to give it away for free.
Doesn't this just show
how f**ked "Justice" is, if you have the abilty to pick and choose where case is heard in order to get the best result for the client?
Justice should be a level palying field, where no matter you are, where it is tried, the results should be consistant.
But as we all know, justice is never equal.
Banned from Spreading the Word !?!
Now that's a shame ...
The snag for Microsoft here is that customers may be worried what might happen to Word/Office and Microsoft in the future and this may affect their purchasing decisions. Delaying the injunction and seeking to extend the legal process might actually hurt Microsoft more if they start losing customers due to the uncertainty. I would have thought they would be better off stomping up cash quickly to make the whole issue go away.
there goes open office too
guess this applies to open office too.
dont you just love patents -
but hey they cant get money from open source. Sorry forgot to be anti MS
I don't get it...
XML is an open standard that allows people to create structures and custom XML in any way that they want.
Gonna have to look up this patent as I think it affects more than Word. What about XMLSpy, any configurator for anything (hardware/software) that uses XML. What about any XHMTL editors - cause basically they are all XML.
"customers would be forced to find alternative products."
What would they be then? It's my understanding that OpenOffice also infringes this patent.
Maybe we'll be banned from downloading that too. Oh hang on. They haven't got any money have they?
I'm not the to say it...
Bomb Canada!
parasitic lifeforms
where there's a large resource, there'll always be something making use of it. Flease on cats, Rhemoras on whalesharks, patent infringement suits on large Corporates.
How does...
...this ruling affect OpenOffice, AbiWord etc? And how does it affect vendors of applications that integrate with Word and also rely on XML for content/metadata?
may I be one of many to misquote...
It's the end of the Word as we know it and I feel fine.
<<Not being able to sell Word would potentially hurt sales of Office>>
I must be a bit thick, suffering from 'flu - fortunately no smell of bacon yet - but 'potentially'????
It'll fuc*k Office. Can't believe I've missed something here. I really must be in 'flu-mode.
Christ-in-shitty-nappies, Openoffice.org/Sun must be jumping for joy.
Of course they can release it...
... just not in Texas. But even there they can just do mail order from outside the state.
Perhaps finally after this idiotic ruling software companies over there might realise the corner they've painted themselves into with moronic software patents. Still, the only people it will hurt are US software companies, the rest of the world doesn't care and will just leave them at the wayside as other companies fly past unencumbered by a patent system designed by morons.
You have to laugh at how even in such a bad recession the US legal system is still slowly killing its own IT sector.
There's some pretty good commments from Computerworld Blogwatch
It's interesting to see that they went for Vista and .NET but settled to target Word. I'm pretty sure Microsoft will have to settle on this one.
I always knew the Canadians would out manoeuvre the US in something like this!
So what about just trying to overturn the patent?
But maybe that is not a possible avenue to explore, as today just managing to find your own arse in a dark room is considered the mark of the American Genius.
But...i4i have an XML authoring tool based on Word...
"x4o© - The One Step Solution to XML Authoring in Microsoft® Word"
I for one am amazed that these guys are getting away with this. How can you patent the use of data in angle brackets?
This is getting old
Troll against troll . . most money wins. Big troll buys off small troll - settled.
<- Checks her software - pats her BSD boxes - feels sad for the average (l)user - GRINS !
"Side-step the patent whilst paying them off"?
Erm, did I miss something here? The point of the patent is to *get* paid for your invention. i4i said "you owe us this much". MS said "we're giving you nothing". Court said "MS, pay this much". At some point, MS and i4i will meet in the middle. If MS are smart, this will involve paying i4i a price which i4i are prepared to accept. If MS aren't smart, they'll dig their heels in and the court will beat them with a big stick until they *do* pay something.
MS vs. Netscape is a good example of this. It tends to be presented as a victory for MS, which of course it was in terms of user-base. But AOL (who by that point owned Netscape) got a $750m payout from MS in exchange for dropping that one. Had MS settled earlier, that figure would have been a whole lot lower.
And even on American lawyers' rates, I doubt Netscape used three-quarters of a billion on the lawsuit, so that represents a solid profit. Sure you've lost your user-base - but do you really want to own the most widely-used web browser, which has precisely zero income (because you're giving it away) and which still needs a team of developers employed (because there are still new features to implement)? Or would you rather have a tax-free three-quarters of a billion dollars in your back pocket which you can invest somewhere that'll turn a real profit? Hmm, tough call...
I think I've missed something here
but isn't the point of XML that you have that holding your data, use a schema to define it, and XSL to style it!?
And some people say that Americans don't get irony.
Original patent a farce
As much as we may not like Microsoft, the original patent is a farce. XML is designed to represent data, so for Microsoft to do so for a wordprocessing document is not original or novel.
Eolas II - The Revenge
How did anyone seriously get a patent on using XML to store data for a word processing application using a custom schema? That's just a normal application use of XML, like millions of apps use.
I'm not normally one to say this, but go Microsoft. Send in Bill and his mates with their baseball bats.
Office: mac
Maybe the mac office update that broke xml office document compatibility wasn't a bug; it was just released too soon. DUM DUM DAAAAA.....!
@The Douros
"Never mind Microsoft... #
By The Douros Posted Thursday 13th August 2009 04:22 GMT
...just tell me if this is likely to impact OpenOffice at all."
This ruling in theory should affect all Office applications (Excel with xlsx, Powerpoint ppx, etc)
Also Open Office and any other application that reads and writes XML will be affected under this ruling.
you forgot
You forgot that contained in the evidence of the case, are a trail of Microsoft email messages clearly showing that they knew all along they were infringing this specific patent, but made no attempt to contact the owner and negotiate an agreement.
Personally, I hope the decision is upheld all the way. Having a major player, with a major product like this getting hurt that badly, is the only way everyone can finally agree that software patents are completely ridiculous and should be banned. Maybe finally the US Patent system can finally get the overhaul it desperately needs.
Drama? What drama
What happens is the big company try to out-gun the little company with lawyers and money. If the little company still has some fight in it, they may settle out-of-court on a licensing fee. Or they can buy the little company. Whatever. Little company makes some money from their patent and big company carries on as before.
Shame they didn't break up MS years ago, though.
@George Schultz
That would be a "point and lick interface", right...?
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Taste of Iceland in Edmonton 2014
Experience Icelandic culture March 5-8
Thanks to everyone who joined us for Taste of Iceland in Edmonton 2014! Click here to view a recap of the weekend's events, and stay tuned to see what city Taste of Iceland will head to next!
To celebrate Icelandair's inaugural flight to Edmonton, the city plays host to Taste of Iceland! For the second time in Edmonton, this free four-day event will celebrate Iceland's food and music from March 5-8, giving the people of Edmonton a taste of what life is like in Iceland.
Watch our 'Taste of Iceland' video on YouTube to see what this cultural event is all about, and follow our 'Taste of Iceland' Tumblr for updates and event recaps! Check us out on Facebook and Twitter too, and follow along with the #TasteofIceland hashtag. Click here to RSVP on Facebook.
Icelandic Menu at Characters Fine Dining, March 5-8
Enjoy authentic Icelandic cuisine at Characters Fine Dining as award winning Icelandic guest chef Hákon Már Örvarsson collaborates with Canadian chef Shonn Oborowsky to offer diners a special menu showcasing fresh ingredients sourced directly from Iceland.
WHEN: March 5-8, 2014
WHERE: Characters Fine Dining | 105 St. NW | Edmonton | AB T5J 1E6
Reykjavik Calling Concert Series, March 7 & 8
Two FREE Reykjavik Calling concerts celebrate music from both Edmonton and Iceland at Brixx Bar & Grill at the Starlite Room. Over the course of this two night event, three Icelandic musicians will be paired with notable Edmonton-area musicians for two nights of unique musical collaborations! Presented by CITY TV, OMNI TV, SONIC FM and WORLD FM, admission to the two-night concert series is free on a first-come, first-served basis. Must be 18 years or older.
WHERE: Brixx Bar & Grill | 10030 - 102 St. | Edmonton | AB T5J 0V6
WHEN: March 7 & 8, 2014, 8PM
PRICE: Free
Featured Artists - Night One
- I Am Machi (Edmonton)
- Sin Fang (Iceland) & Cygnets (Edmonton)
- Lay Low (Iceland) & Kaley Bird (Edmonton)
Featured Artists - Night Two
- Hermigervill (Iceland)
- DJ Ten-O (Edmonton)
- The Specialist (Edmonton)
- DJ Degree (Edmonton)
Icelandair Breakfast, March 7
Join us for a special breakfast with the Prime Minister of Iceland, Sigmundur Davíð Gunnlaugsson, on Friday, March 7 at 7:30 a.m. Icelandair and Capital Ideas will host a business breakfast in which attendees can hear from the Prime Minister of Iceland and listen to a panel of expert guest speakers discuss the important tourism and business links between Canada and Iceland.
WHEN: Friday, March 7 | 7:30 - 9:00 AM
WHERE: World Trade Center Edmonton | 6th Floor, 9990 Jasper Avenue | Edmonton, AB
REGISTRATION: Click here to register.
Win A Prize By Finding Taste of Iceland's #IcelandSecret!
We've hidden several Icelandic secrets throughout the weekend's Taste of Iceland events and need your help in finding them! Keep your eyes peeled at Characters Fine Dining, Brixx Bar & Grill and elsewhere around Edmonton to discover secrets about Iceland. Whenever you find a secret, share it via Instagram and Twitter using the hashtags #IcelandSecret and #TasteofIceland - think of it as a digital scavenger hunt. At the end of the weekend, we'll pick a secret sharer and send them an Icelandic prize pack! The more you share, the better your chances are of winning!
About Taste of Iceland
Taste of Iceland in Edmonton is presented by Iceland Naturally in cooperation with: Icelandair, Reyka Vodka, Blue Lagoon, Icelandic Glacial Water, Promote Iceland, Characters Fine Dining, Brixx Bar & Grill at the Starlite Room, CITY TV, OMNI TV, SONIC FM, and WORLD FM.
Iceland Naturally is a cooperative marketing organization that promotes the tourism, services, products and culture of Iceland. It represents the true essence of Iceland, its creativity and spectacular natural wonders. The group is comprised of Icelandair, Icelandic Group, Islandsbanki, Reyka Vodka, City of Reykjavik, Icelandic Glacial Water, Blue Lagoon, Keflavik International Airport (KEF), Landsvirkjun, Promote Iceland and the Government of Iceland.


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Nutrition advice
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Gateway Natural Area
Gateway Natural Area is the kind of place you will want to bring your family for a day in the mountains and definitely a place you will be proud to say is part of Fort Collins. Gateway Natural Area (formerly Gateway Mountain Park) is the site of the city's old water filtration plant, where the North Fork of the Poudre River joins the main Poudre River. Visitors enjoy it because its tucked away from the noise of Highway 14 and Gateway is only 15 miles from Fort Collins! You'll find hiking trails, a designated launch area for kayaks and canoes, fishing, picnic tables with grills, informational kiosks and a natural playground.
Most of the materials for the natural playground were reused/ recycled or were found on site. Elements include stepping stumps, a rock streambed, a wooden boardwalk, a sandy area, a carved boat, a rustic log ladder, rock walls and a willow tunnel.
Two picnic shelters are available on a first-come, first serve basis or can be reserved (see below).
The daily parking fee at Gateway Natural Area is $5 (check or cash only). Parking is free in December, January, and February. An annual pass is available and can be purchased at the Natural Areas Department, 1745 Hoffman Mill Road (8-5 M-F, check or credit card only) or at the Gateway Natural Area Office (hours vary, credit card, check or cash).
TrailsAccess to the Black Powder Trail, the North Fork and Seaman Reservoir is OPEN as of Friday, May 23, 3 p.m. The bridge providing access to these areas has been repaired. Trail map >>>
Gateway Natural Area is open from dawn to dusk.
Gateway Natural Area is located at 5216 Poudre Canyon Highway (Hwy 14). Take Highway 287 to Highway 14 West, then travel 5.2 miles on Hwy 14 West. Gateway Natural Area is on the right side of the road.
Events & Activities
- Free educational activities and events in June-October are listed in the Tracks & Trails booklet guide.
- Last minute activity additions, trail recomendations and events offered between November-May are in our free monthly electronic newsletter- sign up in the upper right-hand corner of this page.
- Free educational programs at Gateway Natural Area are available for groups by request, call the Master Naturalist Program at 970-416-2480 or email .
Related Information
- Gateway Natural Area Brochure (PDF 2MB)
- Important Rules (PDF 363KB)
- Group & Event Guidelines (PDF 372KB)
- Shelter Guidelines (PDF 370KB)
- Annual parking pass application (PDF 367KB)
- Fees at Gateway Natural Area


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The Appel Room
Bill Frisell: When You Wish Upon A Star
Music From Film & Television
The role of music in classic film and television has always been considerable. With When You Wish Upon a Star, the ever-versatile guitarist Bill Frisell draws upon the sentimentality of music heard on screen and how it shapes and informs our emotional relationships to what we see. Frisell, whose own music has been featured in major motion pictures like Finding Forrester and The Million Dollar Hotel reflects: "Music is so rich with all the associations that go along with it, whether it's the words or a memory you get when you hear it." Violist Eyvind Kang, bassist Thomas Morgan, drummer Rudy Royston, and singer/violinist Petra Haden - who recently released her musical ode to classic film, Petra Goes To The Movies - will join Frisell in re-imagining time-honored gems like "When You Wish Upon a Star," "Alfie," and "Moon River."
Free pre-concert discussion nightly, 6pm & 8:30pm.
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President Bush sizes up his shoe-attacker, plus more from Jim Carrey, Paris Hilton and other stars. By Christie LaRusso
Credit: Eric Charbonneau/WireImage; Summit Entertainment
Updated: Friday Dec 19, 2008 | 06:00 AM EST
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