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L203 - 1 New Bridge Gardens
Cottage | 3 bedrooms | sleeps 6
|Key Info
on the edge of Loddiswell, a smart, double-glazed town house, 50 yards off a residential cul-de-sac. Built on three levels. Long farmland views from upstairs. Gravelled area in front and small enclosed garden (barbecue) to the side and back. Inside, hall; bright, colourful living/dining room (TV/DVD, iPod dock) with patio doors to garden. Well-equipped fitted kitchen (dishwasher, washer-drier, microwave, freezer) with breakfast bar. On the first floor, two smallish bedrooms – a double (5' zip-linked bed or 2'6" twins), and one with two single beds; bathroom (suite plus bath-shower). On the second floor, a large double (6' zip-linked bed or twin) with wood floor and en suite shower-room (suite). Only 8 miles from Dartmoor or the coast and well placed for walking, especially in the Avon valley. Much praised.
|Sleeps up to 6, 3 bedrooms
|Will consider
|Short breaks (1-4 days)
|Car advised
|Family friendly
|Great for children of all ages
|No pets allowed, No smoking at this property
Features and Facilities
|DVD player
|Kettle, Toaster, Iron
|Dishwasher, Cooker, Microwave, Fridge, Freezer
|3 bedrooms, 2 bathrooms of which 2 Family bathrooms
|Single beds (2), Double beds (2), Cots (1)
|Towels provided, High chair
|Private garden
|Secure parking
|Further details indoors
Please bring your own beach towels.
The agent has its own star rating system to quantify interior quality, comfort and ambience. This property has been rated 4 star.
The West Country region
The South Hams: southernmost Devon; between the river Dart and river Tamar and south of Dartmoor, lush farmland and wooded river valleys turning to beautiful estuaries, its coast very beautiful and remarkably well preserved – sandy beaches and mighty cliffs between those estuaries, amazingly little sprawling modern ugliness. Inland too, away from main roads, it remains surprisingly peaceful.
Among special coastal places are Dartmouth; sheltered Blackpool Sands; Slapton's long curve of pebble beach and nature reserve lagoon; the cliffs about Start Point and Prawle Point, Bolt Head and Bolt Tail; East Portlemouth's beach and Salcombe's location and views; Thurlestone proving that family seaside places don't need to be brash; Bigbury's huge sands and the fun of getting to Burgh Island; waterside, oak-wood-sheltered Noss Mayo/Newton Ferrers; many others, less easy of access, are for you to discover.
Kingsbridge and Totnes, both old, attractive and small, are the towns at the area's heart; Plymouth – the West Country's biggest town, with Naval base, ferry port, theatre, cinemas, history, Hoe (great views) and Barbican (where the life is) – is on the area's edge. Dartington Hall is an arts centre (films, plays, music, dance) with lovely gardens. Pleasure cruisers ply the Kingsbridge estuary and Dart and Tamar rivers.
Loddiswell: little hillside village (pub, essential shops, church) above the beautiful river Avon valley, 3 miles from Kingsbridge, 5 from the sea (beaches) at Thurlestone and Bantham or Bigbury-on-Sea. Fishing lakes and lovely gardens to visit nearby.
Availability Your dates are available
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This holiday home hasn't got any reviews yet. The average rating on Holiday Lettings is four out of five. This place could be newly added or perhaps it's a well kept secret. Either way, it's time to reveal all.
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You're booking with
Bookings Team at Helpful Holidays (Property Manager Helpful Holidays)
- 3 Years listed
100% Response rate
Calendar last updated:31 Oct 2014
Based in United Kingdom
- English
Payment accepted
Credit cards accepted
- Landline
- 08431040730
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Components Report Categories
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This post has been a long time coming. When I wrote Personal Guidance System I had no idea I was about to take a six month sabbatical. I had just hit the six month mark on the Gerson Therapy when life took a turn I could not have foreseen.
First, I was having problems on the therapy (full details forthcoming in another post). Then my husband was laid-off. Finally I was about to have multiple, and unexpected, surgeries. Every sign in my path made it clear that I could not continue the Gerson therapy beyond six months. To say I was devastated would be an understatement, and yet I also felt proud that I was able to do it for as long as I did! It is a hard, yet remarkable, program and I learned so much about myself while on it. Over the last several months, since Gerson, my nutritional healing protocol has ebbed in and out of different therapies. The one constant being my unwavering commitment to nourishing my body to wellness.
I don't mean for this post to be so nebulous. I just wanted to let you all know that I am still here, still kicking, and still working at the office of healing! I'm not quite up and on my feet yet (both literally and figuratively), but hope to at least be able to post once a month or so until I am strong enough to return FT.
I promise to share the details of this wild ride moving forward.
Thinking all the best of you…
All love,


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1/2 Photos of Pimm's Cup
Prep Time:
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This is really great, light and refreshing for those balmy summer days. Garnish with a cucumber spear.
Units: US | Metric
Lavender and Strawberry Fruit Cup from Wolds Way Lavender...By French Tart
Serving Size: 1 (1323 g)
Servings Per Recipe: 1
Make this season merry, bright and manageable with our easy ideas.


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About the Company >
Our CredentialsOur credentials include certification from the Architectural Woodwork Institute, and numerous references.
AWI Certification
Warranty InformationAll of products we provide include the provision of complete shop drawings and details. When approved by the owner and/or architect, they constitute the agreement that they represent the work to be performed. All work so performed will be warranted for the period of one year to be free of defective materials and/or workmanship. Extended warranties can be negotiated. Samples are available: Samples are provided as part of the submittal process under the same parameters as the shop drawing process.
ReferencesWe are proud of the quality of our work, and the professionalism and dedication of our staff, and can provide references from our clients and their agents. Some samples:
"The work in general is excellent. Skagit did a very high quality job, with beautiful material and excellent fit and finish."
From: punchlist / Callison Architecture, Inc.
"I want to personally thank you for your outstanding work on the Bagley Wright Theatre project."
From: job superintendent / W.G. Clark Construction Co.
"[the owners] are extremely satisfied with the finished product and are very impressed with the lack of warranty items encountered to date in comparison to other facilities they have constructed."
From: chairman / Lease Crutcher Lewis Contractors
" it is the intent of this letter to recognize the excellent job that we feel Skagit Architectural Millwork has done on the Cordata Project."
From: field staff / Koll Construction
We would be happy to supply you with copies of the original letters, upon request.
|All content is copyright © Skagit Architectural Millwork, 2001-5


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Wednesday, July 16, 2008
Appearance Is Entirely Misleading
2 comments:
- Peter said...
Heh, assuming that article is a new one it must've took Baggini a long time to write it - the lecture he refers to was back in January!
Anyway, Baggini writes that -
"His peers regard him [Scanlon] as one of the most important moral and political philosophers working today, and he is virtually unknown outside academe."
I thik that all contemporary moral and political philosophers are probably virtually unknown outside academia (there's maybe a few exceptions like Peter Singer). I mean ... Bernard Williams did work for Parliament, but nevertheless I reckon 99 out of 100 non-philosophers couldn't tell you who he is (maybe more would just know him as Shirley Williams' husband?).
- 1:44 pm
- Rob Jubb said...
Just off the top of my head, Dworkin and Sen? Martin O'Neill, given that he has a column in the new Statesman? Nagel, because he writes for things like the LRB and NYRB? Scanlon could be more visible than he is (and that's ignoring moral philosophers, whom I know nothing about really any more). The amicus brief he cites as an example of the difficulties philosophers get in to when they intervene in public debate I remember as being really really unsympathetic, although I may have just totally misremembered it; failures of public reason (he smiles).
- 10:34 pm


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The Royal Baby Gift Guide
Kate Middleton is officially in labor! While you wait for the wee one to arrive, browse our luxurious royal gift guide, filled with items that are fit for a little prince or princess.
By Alyssa Vingan
Hansa Ride-On Giraffe
An exotic toy for a very special boy (or girl).
$456, at Barneys.


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This a condiment prepared with tomatoes and Himalayan spices and herbs.
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The Astor Theatre to Close: (Reblog) Some Clarification
August 25, 2014 § 1 Comment
Melbourne's iconic Art Deco theatre, The Astor, will be no more by May of 2015. This news is saddening to thousands of patrons, including myself. So many memories have been made in this historic theatre, and will certainly continue to be made in the months leading to its close.
Originally posted on The Astor Theatre Blog:
It's been a very difficult and emotional weekend as our announcement has reached far and beyond 100,000 people. We have received thousands of messages across email, twitter, Facebook, this blog, through our website and of course at the theatre itself. There has been an incredible and surmounting support for what we do here at the Astor Theatre, for that we are grateful and humbled.
A number of questions have arisen from those messages and though we do our best to reply personally to every query we receive, we feel that it might be best to address here some of what is most frequently asked.
The building, the land, the 1929 Western Electric amplifier, original screen and original projector are registered. The details of that listing can be found in the Victorian Heritage Database. The building is also listed on the National Trust register. This…
View original 400 more words
#TuesdayTunes: The Civil Wars – "Kingdom Come"
August 9, 2014 § Leave a comment
A not so #TuesdayTune, seeing that it's already early Saturday morning, but anyway, here I am (…♫ once again.)
This week's musical news flash: The incredibly talented folk duo: The Civil Wars, part ways. So I thought, as I dry my tears, that I should share one of their fantabulous tunes.
I've chosen Kingdom Come, a track which also featured on The Hunger Games Motion Picture Soundtrack. This definitely won't be their last #TuesdayTunes appearance.
Fare-de-well Civil Wars, we look forward to solo material in the not so distant future.
#TuesdayTunes: Mcfly – "Love is Easy"
July 31, 2014 § Leave a comment
My apologies! This week's #TuesdayTunes entry is very late; It's already Thursday afternoon here Melbourne. Anyway…better late than never!
Today I'm sharing a bundle of cute-ness: Love is Easy by British band Mcfly, which you may recall being very popular during 2012/2013.
Rather than the oh-so-common "met you in the club" junk, prevalent in today's music, the musical, lyrical combination of Love is Easy captures the light-hearted innocence of true love's beginnings. Two thirds of the way into the song an audio-clipping, or rather a film quote, further characterizes the delight of love's first moments. Within an instant of first hearing it I recognized the quote being from the 1946 film and family favourite: "It's A Wonderful Life":
What is it you want, Mary? What do you want? You want the moon? Just say the word and I'll throw a lasso around it and pull it down. - George Bailey (played by James Stewart)
- from a scene where similar affection, to that of the song's protagonist, is being expressed. The quote rounds off the song, the lover not only expressing his love, and the changes it has made to his outlook on life, but the fact that love is enabling him to do absolutely anything for the good of the beloved. It's beautiful.
Adding to all this, the music video is cleverly filmed and choreographed, the band performing center stage of an old theater in a manner reminiscent of The Cure's "Friday I'm in Love" video (which I will discuss in another edition of #TuesdayTunes,) whilst remaining very sweet; up-keeping with the song itself. After showing it to my youngest sister the first time, she begged me to play it again and again and again in the proceeding months.
I see it as one of the classic love songs of this decade.
Hope you enjoy it! ~
#TuesdayTunes: Simon & Garfunkel – "Benedictus"
July 22, 2014 § Leave a comment
I grew up with the music of Paul Simon and Simon & Garfunkel playing in the background. My parents had the double disc Anthology album; it was quite literally the soundtrack of my childhood. I have fond memories of running about the house, bouncing on my parents bed with my little brother and sister, singing lyrics I didn't understand and confidently pronouncing 80% of them incorrectly. Listening to their songs now I appreciate the stories they tell, as well as having realized what those gobbledygook words I misheard actually were. I take pleasure in their music even more-so than I did as a kid, (and that's a pretty big feet, if you knew just how much the 4 year old Gabby enjoyed them.)
Though I've heard a range of their material over the years I recently came across one recorded in 1964, that I had never heard before. It had, and still has, me captivated. It's name is Benedictus.
There's no denying that this song resembles Chant, and according to wiki (tut-tut Gabby,) "[...]was arranged and adapted from two-part a capella motet by Orlande de Lassus"
The words sung in Latin are,
Benedictus qui veniti in nomine Domini
which translate to:
Blessed is he who comes in the name of the Lord.
It's gorgeous; certainly invites me into a peaceful and prayerful disposition.
I hope it does for you too!
Enjoy #TuesdayTunes ~
#TuesdayTunes ~ Intro + Jessie Ware – "Wildest Moments"
July 16, 2014 § 1 Comment
It has been a while since I've written on my blog. This Tuesday I got to thinking of a way to motivate myself to write here regularly, that is, getting into the habit of posting about a specific topic, on one specific day each week. A music related post came to mind.
The plan is that I would post on twitter, tumblr, FB etc. and *hopefully* feature an in-depth version on my WordPress blog. I have decided that the name of this venture will be #TuesdayTunes.
Music & Me:
I have an eclectic taste in music. I don't feel the need for my preferences to be based solely within a genre, era or to be swayed by popular opinion. This doesn't mean I won't listen to music which is considered popular, but that I will listen to what I enjoy, and not to what I am told I should enjoy by the prevalent culture. This allows me to grow a continuous anthology, enabling me to appreciate all I have come upon over the years – rather than looking back in embarrassment. I'd like to share these discoveries, as well as my old favourites.
So, without further ado, #TuesdayTunes:
#TuesdayTune: Jessie Ware – "Wildest Moments"
Today's #TuesdayTune is Wildest Moments by Jessie Ware. I discovered Jessie Ware earlier this year via the internet.
Previously working as a backing vocalist for a number of musical acts, Jessie emerged as a solo artist in 2011. Jessie possesses a genuine talent which can be heard not only in her studio recordings, but also in her acoustic and live performances (something which isn't seen so often today.)
Some interesting trivia; Jessie's song, Wildest Moments, is based upon the turbulent yet devoted relationship she shares with her best friend:
"…it came after this huge argument with my best friend [...] this song really was like a kind of love song to my best-friend, but also kind of highlighting the fact that we can be the best but we can also be terrible together. I really love that people can relate to it though, for any kind of relationship." *
I find Jessie Ware a perfect listen, when you want to sit back after a long day and unwind.
Enjoy ~
Habemus Pappam!
March 14, 2013 § Leave a comment
We have a Pope!!!!
Viva il Papa Francisco! What a way to start the day, we are all excitement and it won't fade. How I ❤ being Catholic!
PRAYER FOR THE POPE (via xt3.com)
Almighty and Everlasting God, have mercy on Your servant Pope Francis I, our Supreme Pontiff, and direct him, according to Your loving kindness, in the way of eternal salvation, that with Your help he may ever desire that which is pleasing to You and accomplish it with all his strength. Through Christ our Lord. Amen.
Lord Jesus, shelter our Holy Father the Pope under the protection of Your Sacred Heart. Be his light, his strength and his consolation.
God Bless you all,
Conclave 2013: The excitement builds!
March 12, 2013 § 2 Comments
Yes, we are still in "Sede Vacante" but Conclave 2013 is almost here! 5:00pm Tuesday March 12 Rome time (just under 5 hours from now), the 115 cardinals will process into the Sistine Chapel as the election of our next pope will begin. A detailed schedule has been released highlighting the happenings of the conclave. Remember, this may take a while! According to Father Lombardi, the first smoke signal at the Vatican will appear around 8:00pm Rome time. Black Smoke: "No Pope elected yet", White Smoke: "We have a Pope!" (though he stresses it is unlikely that a pope will be elected by the end of the first round.)
Here's a little low-down on what we Catholics believe about the Pope: As Catholics we believe that the pope IS the successor of St. Peter; the apostle of Our Lord Jesus Christ. In the Bible we see Simon-Peter as a man who struggled continuously, but ultimately stayed true to Our Lord and His Church. Jesus himself established Peter as head of the church in Matthew 16:18. Something to get straight is that the pope is a human like you and I, he IS NOT God, therefore the pope is not perfect. As Catholics we believe he is only infallible in matters of faith & morals. In these areas he is under protection of the Holy Spirit, as it is the pope who serves as a guide to the Church on earth. We believe that God IS our Almighty Father, but just as we each have a dad here on earth so too does the pope serve as an earthly dad to the Church. :D
Like many young people this will be the second conclave in my lifetime, and it is terribly exciting! Last time around I remember being upset because our beloved Pope John Paul II had passed away. He had been a constant figure in my life, the only Vicar of Christ I had known, so at 10 years old I couldn't believe that he had passed from this life. The conclave was completely new to me, black smoke, white smoke and the Holy Spirit's guidance in the Cardinals' decision. The wait seemed so long, but when it finally concluded it was Cardinal Ratzinger, who took the name of Benedict XVI, emerging to greet us – it was beautiful to watch.
As so many have said over the past weeks, Papa Benedict's resignation was a shock, (even now.) We have been witnesses to the humility he has displayed in doing so, in understanding his limitations and ultimately God's will for him – it's that which, along with the immense contributions he has made for our faith, will remain with us . Papa Benedetto XVI Emeritus is a great man who did a great deal for the church, and he will always be in our prayers.
We are also reminded in this time that Our Lord Jesus is the head of the church, and that we are but His unworthy instruments.
As a baby I was present at Blessed Pope John Paul II's beatification of St Mary Mackillop of the Cross (I actually don't remember it, though I have seen the photos.) I was also fortunate to have seen Pope Emeritus Benedict XVI when I was 14, at World Youth Day 2008. I pray to one day have the chance see our new pope! Oh, how I'd love to be there at the Vatican to hear and see the new pope emerge, but I know God intends me to join the members of the church in spirit as we wait for our new papa!
Remember to keep Papa Benedict XVI in your prayers. Pray for the cardinals. If you haven't done so already spiritually adopt a cardinal here!
There's a heap of fun things to do online as we wait and pray together for the proclamation "Habemus Papam!" (like the Pope Name Predictor Competition, Conclave App etc. ^.^ ) You can watch live coverage on EWTN at ewtn.com or on xt3.com, receive live updates at various Catholic websites. Be sure to join the #TeamCatholic peeps on Twitter, we're pretty awesome. Do some exploring and be sure to share what you find!
God Bless you all and let's keep praying!
Gabby x


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3 minute long video!
3 minute long video!
Gulliana shows off her delicious body in a couple of outfits them gets rid of them all together so she is ready to take on a cock.
This guy had his camera out so he could keep the memories for a lifetime. He filmed while fucking her in all kind of positions before he shot a load of cum on her face at the end.
Watch the video from this scene here!
Gulliana got furious when her neighbor hosed her down. Her friend got wet as well and he went home with her to change into dry clothes.
This was a blessing in disguise for him cause not only did she strip down in front of him but she let him feel her up as well. Things evolved fast from there and soon enough he was licking her clam. He pulled out his wiener and luckily for him she sucked it before they fucked like mad in bed.
Watch the video from this scene here!
Gulliana gets to handle a huge white schlong in this episode and she has all kind of tricks up her sleeve! She fucked and sucked it and also threw in a footjob for good measure. At the end the dude jizzed on her lovely feet!
Watch the video from this scene here!
Gulliana surprised her boyfriend in bed in some sexy lingerie. He thought it was sexy as well so he kept it on while nailing the living shit out of her. He drilled her in all kind of positions then shot his load all over her smiling face!
Watch the video from this scene here!
Sexy Gulliana strips off her white lingerie and spreads her flawless punani for the camera.
See more hot babes at Hustler!


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Booker TBooker Tio Huffman, Jr.
- Birthdate: 03/01/1961 (age 53)
- Height: 6'3"
- Weight: 256 Ib
Booker T is regarded as the greatest African-Am...
-- WWE will hold their latest NXT taping at Full Sail University in Winter Park, Florida tonight. The first NXT champion being crowned in a tournament final between Jinder Mahal and Seth Rollins.
Also advertised as appearing are The Big Show, Jim Ross, Dusty Rhodes, Richie Steamboat and Kassius Ohno.
You can purchase tickets starting at 4 PM at the Full Sail Box Office (141 University Park Drive, Winter Park, FL).
-- This is the eighth edition of Booker T's "Reality of Wrestling" bring you the top unsigned talent from around the United State and also getting a small peek inside these young men's lives.
-- Wild Talk Radio sent the following along:
Kayfabe Wrestling Radio
Hosted by Alan Wojcik & Spug
Listen Live on Tuesday Nights 9pm ET on www.wildtalkradio.com
Check out the archive- http://wildtalkradio.com/kayfabe/kayfabe072412.mp3
Former TNA Wrestling talents and one of Crossfire Wrestling's hot tag teams, Chase Stevens and Cassidy Riley, The Hotshots, joined Kayfabe Wrestling Radio Tuesday Night. In a nearly 90 minute interview, they discussed Cassidy's college football knowledge and the recent Penn State sanctions, Chase's acting projects and experience, their involvement with the wrestling gaming industry, their views on the TNA product in the post-Russo era, James Storm and how far he's come, how they think they compare against so of the great tag teams of the past, the upcoming August 4th "Once in a Lifetime" event and their pending match with the Diamonds in the Rough, Bret Hart's involvement with Crossfire and his upcoming seminar which they are both a part of and so much more.
If Cassidy's was a part of the WWE 13 game and who they possibly are motion captured as:
CR: "Yeah, yeah I was. I signed a deal to do the UFC game that was coming up; that would be coming out soon. Then three days before I was supposed to go to San Diego to start shooting, I got a phone call that was the THQ San Diego office had closed down and had sold the game to EA Sports, and they were moving production to Vancouver, so that didn't look like it would be going through now… It's not really anything I'm allowed to talk about until the game actually releases. But, I have seen a lot of it and it's going to be awesome. They've started previewing some of the stuff last night in the 1000th episode of RAW. It really was cool sitting back and watch the commercials and just recognize some of the stuff we had done, so that was a good feeling. In a small way, it's kind of like I was a small, minute part of that show last night, with the commercials and all. It was a great experience; Chase has done a lot of work out there too, you know that love him and he's awesome when it comes to mo-cap. It's just been a really good gig for us the past several years."
CS: "It's real cool playing the games when they come out, seeing the character you did, gets to walk down to the ring and you can pick out here and there little things, like how you walk and then you can sit around and call you friends and say 'No, that's really me. That's not Triple H there, that's me.' Yeah, that's fun"
CR: "And that's the neat part too. After we've all been out there and once you get through the commercials, or whatever that they're having advertising for, you can pick out, 'Ok, that was Chase, that was me, that was (Mike) Mondo. Whoever.' You may not exactly remember the shot but you can just tell subtle movements and little ways people do different stuff in the ring. It's easy to figure out so that makes it real cool."
On what they've seen from TNA Recently post-Russo (Pritchard/Lagana Era):
CS: "I do watch, I see it here and there. I travel now on the indys a lot and I am booked Tuesday through Saturday so it's hard for me to just sit and watch it. But I do Tivo it and try to catch little thing here and there. I don't see too much of a charge, really, outside of trying to revive the X Division right now. Bring in some of the old X Division guys and local indy guys and pushing the X Division back up to here it used to be; just trying to revive it. That's what caught on with TNA in the first place, when me and Cassidy were there: these young, high-flyers. That's what that company is about; it wasn't about the main heavyweight materials guys, they...


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I'M GONNA SING Lyrics - Hank Williams
Recorded by Hank Williams, Sr.
Words and music by Hank Williams, Sr.
When [G] I get to Glory, I'm gonna sing, sing, sing
I'm gonna let the [A7] hallelujahs [D7] ring
[G] I'm gonna praise my blessed Saviour's name
When I get to Glory, I'm [D7] Gonna sing, sing, [G] sing.
[G] In this world of sorrow, I've seen trouble and woe
When I get to Glory [A7] I'll see no [D7] more
For [G] I know my prayers have not been in vain
When I get to Glory, I'm gonna [D7] sing, sing, [G] sing.
Sometimes I get so weary inside
Then I recall how my Jesus died
Up there I know, there'll be no pain
When I get to Glory, I'm gonna sing, sing, sing.
Up there no tears will blind my eyes
And I'll walk along by my Jesus' side
I'll meet my loved ones all once again
When I get to Glory, I'm Gonna sing, sing, sing.
Click here to submit the Corrections of I'M GONNA SING Lyrics
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The following area is only for review, if you want to submit the lyrics or the corrections of the lyrics, please click the link at the end of I'M GONNA SING Lyrics.


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Vikings Dynamic Duo At It AgainPosted by on November 16, 2009 – 6:18 am
It was back on October 29 that we first made note of the dynamic duo consisting of RB Adrian Peterson and WR Sidney Rice. At that point, the 2 players had combined for 1,232 of the Vikings 2,475 (49.8%) total yards of offense.
Since that time, the Peterson/Rice duo has not slowed down and they reached another milestone on Sunday. For the 2nd time this season, the dynamic duo set a new team record for most yards by a rushing and receiving tandem in a single game, breaking the mark of 319 yards that they set on 10/18 against the Baltimore Ravens with a 334-yard joint effort against the Lions.
Peterson atoned for 143 total yards (133 rushing, 10 passing) while Rice registered 201 receiving yards. As a team, the Vikings tallied 492 yards, giving the Peterson/Rice duo 70% of the Vikings total yardage.
For the season, the Vikings dynamic duo has collectively gained 1,703 of the team's 3,322 yards (51.2%).
Tags: Adrian Peterson, Sidney Rice
Posted in All, Mike Wobschall | 27 Comments »
27 Responses
to "Vikings Dynamic Duo At It Again"
By Kevin Wilson on Nov 16, 2009 | Reply
"Peterson atoned for 143 total yards " Huh? "Atoned"? Did you mean "accounted"? "Atoned" would suggest he was apologetically making up for those 143 yards, in which case you don't explain how he was atoning (or why).
By Youcef on Nov 16, 2009 | Reply
To Kevin,
lol, I think they misused the Thesaurus.
By rod meidl on Nov 16, 2009 | Reply
i for one hope the packers never retire farve,s number, he doesn,t deserve it. it,s always about how he gave his all , he doesn,t have anything to prove. so he,s got a gripe with the packers org., not once has he ever said thanks to the packer fans. thanks for buying the jerseys, thanks for the 16 years of screaming for him and loving him, he,s a big man alright. he ought to be ashamed of himself. vikes are goin down, sorry to say, no super bowl. your all a bunch of hipocrites. i,ll bet vike fans loved him for the last 17 years huh? even with farve ya still suck.
By Chaz on Nov 16, 2009 | Reply
you know what… this guy is right… our 8-1 team just sucks… haha. that is a lot of spite, and i feel as if it stems from jealousy.
By Puckersux on Nov 16, 2009 | Reply
Stupid pucker rod,
Please note division record. Please note win loss column. let me say respectfully hahahahhahahaha
By Peggy P on Nov 16, 2009 | Reply
To Rod Meidl: Where have you been? Brett has repeatedly expressed his gratitude to the Packers and the fans for his years in Green Bay. It is not only the fans, but also the city of Green Bay and the whole state of Wisconsin who should be grateful for his 16 years as a player, but also for the financial impact he had on the city and state. Seriously, do you really believe he made money on any jersey/merchandise that was sold?
Get over it!
By Popper on Nov 16, 2009 | Reply
Atta girl Peggy, you are 100% right. Being from Wisconsin, just short of Green Bay, I am, and always will be, a Brett Favre Fan. It is unfortunate the other (so called) fans don't appreciate all he did for the Green Bay franchise. I hope he continues to play for as long as he wants to because I thoroughly enjoy watching him from week to week. GO BRETT FAVRE AND VIKINGS!!!!
By RamessesII on Nov 16, 2009 | Reply
Gimme Brett… or gimme deatt…!
By Favrefan on Nov 16, 2009 | Reply
rod, you're an idiot.
By wiscvikingfan on Nov 16, 2009 | Reply
I'm glad to see that each week we have different players that get the top awards for outstanding plays during a game. I hope we keep this up, because it only goes to show the depth the Vikings have and that's what makes a team a Super Bowl winner. Go Vikes Skol Viking
By Brem on Nov 16, 2009 | Reply
Rod, I think you had better keep an eye on your computer…there seems to be a snot nosed little 10 year old typing things under your name… There is no way that a true FOOTBALL fan would say the ignorant things that were said. When Favre was a Packer I hated playing against him as a Vikings fan. With him on the field there was always the chance at a Vikings loss. I was glad that he went to the Jets when we didn't get him last year because we wouldn't have to play him. But now that we do have him…I am excited that there is finally consistency at our QB position. One asset that we have not had since probably Tommy Kramer…and that is pushing it…maybe even since Fran Tarkenton…it has been that long… I actually saw a lot of class from the Packer fans after the Vikings win there in Lambeau last week. Of course he was expected to be greeted with boos and the like…because that is competition. But after the game was over, the TRUE football fans showed their respect and adoration for him.
By bass8 on Nov 16, 2009 | Reply
rod meidl, you obviously got a bug up your butt. Brett has always said that he never had a problem with the Packer fans. I suppose you are one of those fans who hears only what he wants and could never accept that they sent Brett away….I am glad they did because he is in a place where he actually has a coach and G.M. who actually respect him…something he did not have in Green Bay….So keep being a crybaby and keep complaining. Us former Packer fans who are always Brett Favre Fans know the truth
By bass8 on Nov 16, 2009 | Reply
By wiscvikingfan on Nov 16, 2009 | Reply
Now to "Rod Meidl" Normally, I would waste my precious time commenting on idiotic remarks. I've always say you put the best team out on the field. You always try to get the best players on your team if the occasion arises. Let go back to where all this turmoil started with the Packer management and 30% of the fans. The Viking released Randy Moss and Farve wanted management to go after him. My husband and I were in a sports bar when the local news was going with the story. Most of the fans at the bar were saying that they wouldn't want Moss in Green and Gold because he mooned the fans (rubbing his behind on the Goal Post), the year before, after scoring a go ahead TD. Fans should stop looking at players and franchises as one entity. Players are separate entities that make up a franchise. In my opinion, Moss would have been an asset to the Packers back then when the Packers had three new receivers that years. Farve was told to mind his own business and he wasn't running the team. That's when, in the ten week of the season, rumors started about when Farve was going to retire, both in local papers and air time during the game. I think that the Vikings fans are the best and want the best to be playing. WE HAVE THAT and Going All The Way….
By hank on Nov 16, 2009 | Reply
bottom line is farve knows how to read defenses better than most of the qbs that ever played and has the arm to take advantage of it…..this coming from a viking fan who hated him because he did it against my favorite team to many times and burned the vikes
By hank on Nov 16, 2009 | Reply
by the way talent surrounding farve both when he was with the packers and now with the vikes makes him that much better
By Popper on Nov 16, 2009 | Reply
Also looking for Winfield to return, hopefully next week when the Vikings go to 9-1. Would like to acknowledge the offensive line for the protection that they give to Brett Favre. Something that was missing for alot of years in Green Bay and still is. Note: sacks on Aaron Rodgers. As we know Brett's not the fastest quarterback in the league, but giving time will pick apart any defense.
By optimisticskeptic on Nov 16, 2009 | Reply
I feel bad for the Pack, they'd be a 7-2 team if they didn't have to play us twice. SKOL
By BRice on Nov 16, 2009 | Reply
Rod Miedl…..Packer Fan with issues. Ease up, enjoy the ride, Mr Favre is a great player who may well take the Vikes to the Superbowl. I enjoyed watching him as a Packer and I am lucky enough to see him as a Viking. How can you not enjoy watching this guy, no matter whose team he is on? This guy loves football and has a right to be on a winning team.
By 4ever on Nov 16, 2009 | Reply
actually the packers might be undefeated or 8-1 also if favre wasn't on the vikings lol
By J-dog on Nov 16, 2009 | Reply
looks like pack fans are green with envy lmao
By J-dog on Nov 16, 2009 | Reply
Is rice turning into a beast or what people.
By thb on Nov 16, 2009 | Reply
I dont want to rain on the AP parade but he has got to stop putting the ball on the ground. I dont care if he gets 2,000 yards this season it will hurt the vikes in the playoffs if he continues to put the ball on the ground. You will not overcome those mistakes in the playoffs against good teams. I think he has the potential to shatter all the records but he has to hold on to the ball if he truly wants to be considered GREAT!
By PurplePeopleEater on Nov 17, 2009 | Reply
I couldn't agree with you more thb. Granted, the first fumble this week was a botched hand-off on a play that they wouldn't dare try in a situation that matters, he still needs to be able to make that exchange flawlessly in practice if they're ever going to try it in a real game. The second fumble was very unsettling, mostly because AP had already broken past all the defenders and someone caught up with him. I thought he was about the fastest guy on the field. Apparantly the extra bulk he added this year is slowing him down a little, and he needs to be aware of that and protect the ball until he hits the ground or crosses the marker.
By travis bickle on Nov 17, 2009 | Reply
Peterson didn't 'bulk up' for the season. That was talked about before preseason started and he just lost some fat weight, replaced it with muscle weight but didn't gain any extra pounds. You should know this as a Vikings fan, it was a big issue. His dad also told him that defenders wanted him to bulk up because it might slow him down. It was a great play by the defender, he just needed to keep it high and tight. He will in the future, it was a blessing in disguise. Much worse if it happened in the playoffs. He didn't slow down any, there are some other guys in the league with excellent speed too ya know. ;)
By SkolVikings on Nov 17, 2009 | Reply
I always hated and loathed Bret Favre when he was with the Packer's. He was the Packer's QB who lead them to a super bowl, and the Vikings were on their long stretch of recycling washed up QB's for one good season. (Warren Moon, Randal Cunningham, Geoff George, etc style) But I always respected Favre as a player because of the way he played. Now I understand that a lot of Farve's later career problems have more to do with the fact that the Packer's dismantled their team and Favre got the junk kicked out of him, much like what's happening to Rodgers today. So now I root for Bret Favre, and it still feels weird. But even if he strapped on another uniform next season for another go, I'd go back to lathing, but the respect would remain.
By Gene Cyr on Nov 18, 2009 | Reply
new name for the defence line wall of pain


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A view of UCSF's 107-acre Parnassus campus, which is located above Golden Gate Park.
UCSF Campus Planning and Community Relations teams met with Parnassus neighbors Feb. 11 to present the proposed Long Range Development Plan (LRDP), which will guide UCSF's physical development over the next 20 years.
The 2014 plan, which will see the University through the construction of a new hospital and campus housing at Parnassus Heights, as well as new facilities at Mission Bay, has been three years in the making so far in an effort to balance the concerns of our neighbors alongside those of the campus in maintaining the caliber of its research, education and patient care.
The previous LRDP, from 1996, guided development through 2012 and primarily focused on the development of Mission Bay. The 2014 plan covers all of UCSF's campus sites and includes physical development proposals for the Parnassus Heights, Mission Bay, Mount Zion and Mission Center locations, as well as potential consolidations of UCSF space at San Francisco General Hospital and Trauma Center. The Draft 2014 LRDP is scheduled to be published in May 2014 and presented to the UC Board of Regents in November 2014 for approval. For more information about the 2014 LRDP, including the community meeting agenda and presentation, visit www.ucsf.edu/lrdp.
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The download and install was a breeze, the help section is very straight forward and easy to understand, the user friendliness is pretty good (although some improvement is needed), and you can customize it to fit your needs. Very important!
The support is excellent! I did have one issue with the send button but it was my fault. I contacted their support team and they responded immediately and were very friendly and helpful as they helped me resolve the issue.
It's a great extension!


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History of Parliament Trust
Journal of the House of Commons: volume 1: 1547-1629
Year published
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'House of Commons Journal Volume 1: 27 June 1604 (2nd scribe)', Journal of the House of Commons: volume 1: 1547-1629 (1802). URL: http://british-history.ac.uk/report.aspx?compid=5326 Date accessed: 27 November 2014.
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Mercurii, 27o die Junii, 1604
Hatton's Estate.
Parsons, &c.
Attending Church.
Swearing, &c.
Jesuits, &c.
Members Contribution.
THE Bill for the Making good of Leases to be made by Tenant in Tail, according to the Form of the Statute of 32 H. VIII. cap. 28, against him or them in the Reversion or Remainder of the Lands, Tenements, and Hereditaments, so hereafter to be leased : - First Reading.
The Bill against such as sell any Ware for Apparel, without ready Money : - First Reading.
The Bill for Reformation of the common Sin of Swearing and Blasphemy : - First Reading.
The Bill to enable Sir Christofer Hatton, Knight, to dispose of certain Lands,Tenements, and Hereditaments notwithstanding a Limitation, or Clause of Perpetuity, annexed to his Estate ; - First Reading.
The Bill for the Increase of the Livings of Parsons and Vicars having Cure of Souls, brought in from the Committee by Mr. D. James, with Amendments; and ordered to be ingrossed.
The Bill to take away all Excuse of not coming to Church, secondly read, and committed - Mr. Alford, Sir Edw. Lewknor, Sir H. Bromley, Mr. Dammett, D. James, Mr. Nath. Bacon, Sir Fr. Lee, Sir Tho. Freak, Mr. Winch, Mr. Fuller, Sir Herbert Crofts, Mr. Herbert Pelham, Sir James Harrington, Sir Fr. Hastings, Sir Tho. Horseman, Sir Jo. Heigham, Mr. Noye, Mr. Prowse, Sir Edw. Littleton, Sir Edw. Hobby, Sir Rob. Wingfield, Sir Tho. Dorrell, Sir Geo. Vane, Sir Jerome Horsey, Mr. Duncombe, Mr. Johnson, Mr. Solicitor, Sir Tho. Beamount, Sir Jerome Bowes, Sir Jo. Thynne, Sir Edw. Sandys, Sir H. Beamount, Sir Barnard Whytstone, Sir Fr. Barrington: - To-morrow, Temple.
The Bill against Swearing, secondly read, and committed to the former Committees.
Mr. Chapman. -
The Bill for the Execution of the Statutes against Jesuits, Seminary Priests, and Recusants, &c. secondly read, and committed. Much disputed. -
Mr. Duncombe: - That such as limited to come once a Month to Church, might once a Year receive the Communion.
Mr. Tay: - That, " ecclesiastical Persons," intendeth all other Ministers. -
The Committee for Religion: - This Afternoon.
Sir Edw. Hobby moveth, for the common Contribution at the End of every Parliament.
Moved, that all Knights of the House might pay ....
All Knights of Shires, the old Order.
5s. and 2s. 6d. moved. -
Upon a Prorogation, or upon a Dissolution.
Q. Whether every Knight of the Shire, and every Burgess, 10 s. and 5 s.
The House divided:
With the Noe, 126. With the Yea, 119.
Usury : - To-morrow, Chequer Chamber. Sir Cary Rawleighe, Sir Geo. Carye, Mr. Middleton. -
Committees for Pening, - To-morrow, Chequer Chamber.
The Bill for the Disburthening of Clergymen of such Affairs as hinder them in their divine Callings and Cures :
- Third Reading.
The House divided. The Noe yieldeth.
The Bill passed.
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Constance Clare-Newman, M.AmSAT has a private practice in Oakland and San Francisco, teaches classes for actors at the Academy of Art University in San Francisco and gives specialized workshops for equestrians, actors, musicians and for employees in the workplace. With a first career in training dressage horses and riders and a second career in performing and teaching modern dance, she is well acquainted with the needs of athletes and performers. She recovered from chronic back pain and injuries with the help of the Alexander Technique. During her career in Dressage, she competed at FEI-levels, (Federation Equestrian International) in the United States and Europe. As a dancer, she performed professionally and taught with Anne Bluethenthal & Dancers and Purple Moon Dance Project. Constance completed a three-year Alexander training program in San Francisco with Frank Ottiwell, (1800 hours of study) and has since helped hundreds of students bring less effort and more ease into their activities.


text: That's right, laugh it up. Although the title of this post wasn't my idea, I did consume a fair share of noteworthy eats in 2011. Whether crazy-delicious, crazy-exotic, or just crazy-crazy, many have managed to make quite an impression. Here are five of the most significant. 5. Pan-Seared ... More >>


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1991 Mitsubishi 3000GT All-Weather Mats
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Baby Name MeaningsSearch 30,000 Unique Baby Name Meanings
The name Cadao is a baby boy name.
Vietnamese Meaning:
The name Cadao is a Vietnamese baby name. In Vietnamese the meaning of the name Cadao is: Song.
People with this name have a deep inner desire to lead, organize, supervise, and to achieve status, power and wealth.Expression Number: 6
for harmony and balance in their lives, and respond positively to beautiful things.
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Was going through my pictures and deciding what to keep, and what to get rid of. Some of these I ran across seem rather funny now. These are pics I've taken in real life, situations I've been involved in, and I've tagged them with my thoughts.
What can you say? It's a Ford!
Never try to push a Dodge with a Honda!
If we're going the same direction.........is that bad?
Sure I leave the keys in the ignition....this is a low crime neighborhood.
Nothing quite like a warm SIG!


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The Multiple Myeloma Genomics Portal is a part of the Multiple Myeloma Genomics Initiative, a collaboration of The Multiple Myeloma Research Consortium, The Broad Institute of MIT and Harvard, and the Translational Genomics Research Institute (TGen). Funding is provided by the Multiple Myeloma Research Foundation. Development of the portal and data curation was performed by the portal team of the Broad Institute and Dana Farber Cancer Center.
The Multiple Myeloma Genomics Portal (MMGP) has been made available to provide access to and limited analysis of the MMGP portal data sets. These include the MMRC funded reference aCGH and gene expression data and additional public multiple myeloma datasets.
The MMGP will be updated with new features such as additional data and analysis tools as they become available.
Jun 3, 2014: The MMGP will be unavailable from 10AM through 1PM EST Friday June 6th for maintenance.
Mar 13, 2014: Survival data (updated yearly) for the patients in the MMRC reference collection is now available upon request. Please contact us if you would like to have access.
Jan 28, 2014: We have investigated the mutational spectrum and copy number profile of 203 patients with MM and other plasma cell dyscrasias, by whole genome sequencing, whole exome sequencing and high density SNP array profiling. We have determined the mutations that are most likely â??driverâ?? events, and we have determined the cancer cell fraction in which these mutations occur. For a complete listing of the available data and analyses performed, please refer to Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy
Sep 24, 2013: The MMGP can now upload data directly to GenomeSpace. To learn more, see the GenomeSpace blog
Sep 18, 2013: The portal will be unavailable from Thursday October 17 through Sunday October 20th for server maintenance.
Sep 16, 2013: 5 additional publications have been added to the curated list of significant Multiple Myeloma publications
Aug 7, 2013: We have added 15 additional publications to the curated list of significant Multiple Myeloma publications
Please register for full access to the data and analyses tools MMGP provides.
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Tutorials, analysis descriptions and other documentation is available at:
clouds summarizing genes frequently altered in the datasets of this
portal are available in the
Mutation tag cloud
New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG)., Ocio EM et al., Leukemia. 2014 Mar;28(3):525-42. doi: 1, 2014
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma., Bolli N et al., Nat Commun. 2014;5:2997. doi: 10.1038/ncomms3997., 2014
DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors., Salhia B et al., Cancer Res. 2010 Sep 1;70(17):6934-44. doi: 10.1158/0008-5472.CAN-10-0282., 2010
All Publications
The Cancer Therapeutic Response Portal provides profiles of the impact of a small-molecule collection of 185 compounds on a panel of 242 cancer cell lines
The Cancer Cell Line Encyclopedia provides public access to genomic data, analysis and visualization for about 1000 cell lines.
Enter a keyword to search for genes, news items and publications. Search
results for a gene include links to annotations and analyses.
Browse, analyze and download
studies and data sets.
The portal provides the
following analysis tools:
Integrative Genomics Viewer (IGV)
Visualize a data set in the Integrative Genomics Viewer (IGV), a high-performance
visualization tool for interactive exploration of large integrated data sets.
Differential Expression Analysis
Find genes that are significantly differentially expressed between two user-defined classes
of samples from an expression data set available on this portal.
Gene co-expression
View the top 20 genes in a data set that are co-expressed with a gene of interest.
Gene Set Enrichment Analysis (GSEA)
Find pathway gene sets correlated with a gene of interest. Domain
experts curate the pathway gene sets based on data from several online pathway databases.
Create your own sample sets based on a
large number of available criteria and use them in differential expression analysis. CREATE SAMPLE SETS


text:
As you've no doubt seen, Kanye West's Yeezus tour merch features Confederate flags and Native American headresses. Like all things Kanye, people feel strongly about it. Depending on who you listen to he's either a bold and fearless artist/genius unafraid to take aesthetic and artistic risks, or a br ... More >>
Two people had a discussion last night that has been a long time coming. A question was asked and with an answer in the affirmative, their entire relationship changed. Though the description sounds like a delightful marriage proposal, this was actually a television interview. "Yes." With one word ... More >>
Not to steal some thunder from Lance Armstrong before his big confession to Oprah is aired tonight--the Manti Te'o story has already done that--but I must make a confession of my own. I've got to get this monkey off my back. I've got to free myself of the burden I've been carrying around for so long ... More >>
The final act in the Shakespearean drama of cycling great Lance Armstrong is about to begin, with the airing this week of his admission to who else but Oprah Winfrey--the celebrity confessor--that he indeed took performance enhancing drugs during his professional career. This is news only in that ... More >>
The Daily News jumped the gun with its cover this morning -- no, Lance Armstrong has not been stripped of his seven Tour de France titles. Not yet, anyway. Last night, Armstrong threw in the towel with a defensive statement posted to the Internet, saying that he was no longer going to fight the dop ... More >>
Kraftwerk fever might have ruffled many of you the prickly way, what with the Great Unobtainable Online Tickets Ruse blighting the band's series of eight chronological album-by-album shows at MoMA this week. But let's look on the bright side! Over the years the Dusseldorf dance merchants have churne ... More >>
What are you up to this afternoon? If you're anything like us, you'll be watching an illegally downloaded copy of The Smurfs 3D while eating the party sub you've been saving since Bastille Day. If you're feeling a little more active, Lance Armstrong has cordially asked you to run through New ... More >>
Lauren ShockeyBright lights, big city. But where to eat?The Village Voice's Obie Awards are on Monday, celebrating the best Off-Broadway and Off-Off-Broadway theater. So what better time to take in a variety of shows and performances? Yet the Theater District can be confusing culinary wate ... More >>
Cyclingnews.com/SirottiContador, now in yellowThe Tour de France is no longer about Lance Armstrong (except for those keeping an eye on federal subpoenas), but there's still plenty of drama going on, even if American cyclists are somewhat irrelevant to it. Take today, for example, when Spani ... More >>
Cyclingnews.com/Fotoreporter SirottiLance stuck close to Contador yesterdayWith a mountain-top finish in the Alps this morning, Lance Armstrong has an opportunity to make up some time he lost to his main rival, Alberto Contador. Or, he can simply stick with Contador and look for a later oppor ... More >>
JunkieCyclist Floyd Landis has finally admitted to doping, four years after he was caught red-handed and was stripped of the 2006 Tour de France championship. But that news is quickly being overshadowed by Landis's reported accusations against his former teammates, Levi Leipheimer, George Hi ... More >>
Professional cycling goes on even after the Tour de France, but you'd never know if if all you did was follow Lance Armstrong. Even before his comeback, he rarely took part in late-season events after the Tour was finished. So there's little news to report about what Armstrong is up to these days ... More >>
The Tour de France got a lot more interesting today, one day ahead of schedule.We already knew that tomorrow's stage into the Swiss Alps would turn up the fireworks in what has been a "slightly boring" race (according to Armstrong himself).The surprise today was that Lance's old teammate George Hinc ... More >>
After an unplanned collarbone fracture, Lance Armstrong's comeback gets back on track this weekend with one of his big goals: Italy's three-week grand tour, the Giro d'Italia.For most casual Americans fans, cycling means the Tour de France, and Lance will race in that spectacle in July. But the Giro ... More >>
The Times crossed its fingers earlier today, hoping against hope that news of Lance Armstrong's crash and injury in Spain didn't result in a fracture. But that doesn't seem to be the case. Cyclingnews.com is now reporting that Armstrong's collarbone was fractured after a spill today on the first da ... More >>
The New York Post this morning -- and others, including the Associated Press -- are reporting that Lance Armstrong's time trial bike, which was stolen after the Tour of California prologue in Sacramento, was recovered when a man, not the thief, turned it in to Sacto cops.The bike, the story says, wa ... More >>
Lance Armstrong's own website, along with many others watching his comeback, repeatedly refers to January 20 as the big day our hero will return to action.But we noticed that the Tour Down Under, the Australian stage race Armstrong has chosen for the first leg of his comeback, actually begins with a ... More >>
Thoughts on book tours, literary self-promotion, and one published writer's blog spat
German robo-pop legends stand still like mean machines
In a 24-Hour mountain bike race, life begins at 4 a.m.
Rx gains in the race against drugs in sports


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Original German. Refers to products originally manufactured in Germany, often when referring to parts used on vintage Volkswagen automobiles. In a similar context, it may also refer to original.
I just installed an OG front seat in my 1954 Barndoor Kombi.
dodane przez Everett Barnes sierpień 06, 2004
a descriptive characteristic, to be old fashioned, traditional in any sense, can be used for a person or object.
That game Hungry Hungry Hippo is totally OG.
dodane przez Octavian Ken grudzień 19, 1999
1) Orange Gatorade
2) Original Gangsta
2) Original Gangsta
"Hey, hit me up with some of your OG, OG."
dodane przez Jordan Cheng wrzesień 20, 2007
orealginal gangsta: meaning no matter what anotha nigga tell you is gangsta u follow your our g-code.
OG Kyle C has been an OG since age 13 when he became his own man.
dodane przez Kyle Charles maj 29, 2007
- ← Poprzednia
- 1
- …
- 12
- …
- 18
- Następna →


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Blackhawk Dynamic Entry Dynamic Duo including one each:SKU: DE-DD
Manufacturer: Blackhawk Clearance - Up to 70% off
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"This new Wozniak design was created after receiving multiple requests for a durable, easily deployable breaching kit that could be used in the majority of breaching situations. The Dynamic Duo includes a twelve-pound ThunderSledge and The Breacher. Front and rear quick release straps allow for immediate "dumping" of the kit by the wearer and also rapid deployment of tools by fellow breachers. Includes: DE-DDQ Dynamic Duo Quiver DE-TS ThunderSledge DE-TB The Breacher Due to the weight of this product, additional shipping charges will apply. Call or email for details.
Please note: Although we try our best to ensure correct product information on our website, we are not responsible for any mistakes or incorrect information. We welcome you to call us with any questions you may have prior to placing your order.


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Reyataz Side Effects
Generic Name: atazanavir
Note: This page contains side effects data for the generic drug atazanavir. It is possible that some of the dosage forms included below may not apply to the brand name Reyataz.
It is possible that some side effects of Reyataz may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to atazanavir: oral capsule, oral powder
As well as its needed effects, atazanavir (the active ingredient contained in Reyataz) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking atazanavir, check with your doctor immediately:Incidence not known
- Abdominal or stomach discomfort, fullness, or pain
- bloating
- blood in the urine
- blurred vision
- chest pain or discomfort
- chills
- clay-colored stools
- constipation
- dark colored urine
- decreased appetite
- diarrhea
- dizziness or lightheadedness
- dry mouth
- fainting
- fast heartbeat
- fast, shallow breathing
- fever
- flushed, dry skin
- fruit-like breath odor
- gaseous abdominal or stomach pain
- general feeling of discomfort
- headache
- hives, itching, or skin rash
- increased hunger
- increased thirst
- increased urination
- indigestion
- irregular heartbeat
- loss of appetite
- loss of consciousness
- muscle pain or cramping
- nausea
- pain in the groin or genitals
- pain in the stomach, side, or abdomen, possibly radiating to the back
- recurrent fever
- severe nausea or vomiting
- sharp back pain just below the ribs
- sleepiness
- slow or irregular heartbeat
- stomachache
- sweating
- swelling
- tightness in the chest
- trouble with breathing
- unexplained weight loss
- unpleasant breath odor
- unusual tiredness or weakness
- vomiting
- vomiting of blood
- yellow eyes or skin
Some atazanavir side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Back pain
- cough, increased
- discouragement
- extra body fat
- feeling sad or empty
- irritability
- loss of interest or pleasure
- trouble concentrating
- trouble sleeping
- Burning, numbness, tingling, or painful sensations
- difficulty with moving
- muscle stiffness
- pain
- pain in the joints
- sleeplessness
- unable to sleep
- unsteadiness or awkwardness
- weakness in the arms, hands, legs, or feet
- Hair loss or thinning of the hair
- rash with flat lesions or small raised lesions on the skin
For Healthcare Professionals
Applies to atazanavir: oral capsule, oral powder
The most common side effects reported in therapy-naive patients during clinical trials were nausea, jaundice/scleral icterus, and rash. The most common side effects reported in therapy-experienced patients during clinical trials were jaundice/scleral icterus and myalgia.
Elevated total bilirubin (at least 2.6 times upper limit of normal [ULN]), ALT (at least 5.1 times ULN), and AST (at least 5.1 times ULN) have been reported in up to 53%, up to 25%, and up to 10% of patients, respectively.
Most patients taking this drug experienced asymptomatic elevations in indirect (unconjugated) bilirubin related to inhibition of UDP-glucuronosyl transferase. This hyperbilirubinemia was reversible upon discontinuation of this drug.
Very common (10% or more): Elevated indirect (unconjugated) bilirubin (up to 87%), elevated total bilirubin (up to 53%), elevated ALT (up to 25%), jaundice (up to 19%)
Common (1% to 10%): Elevated AST, jaundice/scleral icterus
Uncommon (0.1% to 1%): Hepatitis
Rare (less than 0.1%): Hepatosplenomegaly
Frequency not reported: Hepatomegaly, liver damage, acute hepatic cytolysis, biliary lithiasis, choledocholithiasis
Postmarketing reports: Hepatic function abnormalities, cholelithiasis, cholecystitis, cholestasis
Elevated total cholesterol (at least 240 mg/dL), triglycerides (at least 751 mg/dL), and glucose (at least 251 mg/dL) have been reported in up to 25%, up to 8%, and 5% of patients.
Very common (10% or more): Elevated total cholesterol (up to 25%)
Common (1% to 10%): Elevated triglycerides, elevated glucose
Uncommon (0.1% to 1%): Anorexia, increased appetite, decreased weight, weight gain
Rare (less than 0.1%): Ketoacidosis
Frequency not reported: Elevated LDL cholesterol, elevated HDL cholesterol, hyperkalemia, lactic acidosis, hyperlactatemia, redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance"), hypertriglyceridemia, hypercholesterolemia, insulin resistance
Postmarketing reports: New onset diabetes mellitus, exacerbation of preexisting diabetes mellitus, hyperglycemia
Very common (10% or more): Rash (up to 20%)
Common (1% to 10%): Lipodystrophy
Uncommon (0.1% to 1%): Alopecia, pruritus, urticaria
Rare (less than 0.1%): Vesiculobullous rash, eczema
Frequency not reported: Photosensitivity
Postmarketing reports: Maculopapular rash, erythema multiforme, toxic skin eruptions, drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, angioedema, Stevens-Johnson syndrome
Elevated amylase (at least 2.1 times ULN) and lipase (at least 2.1 times ULN) have been reported in up to 14% and up to 11% of patients, respectively.
Very common (10% or more): Nausea (up to 20%), elevated amylase (up to 14%), elevated lipase (up to 11%)
Common (1% to 10%): Abdominal pain, diarrhea, vomiting, dyspepsia
Uncommon (0.1% to 1%): Dry mouth, flatulence, gastritis, pancreatitis, abdominal distension, aphthous stomatitis
Frequency not reported: Acholia, colitis, constipation, dental pain, esophageal ulcer, gastrointestinal disorder, peptic ulcer, sialolithiasis/parotid gland lithiasis
Nervous system
Very common (10% or more): Headache (up to 14%)
Common (1% to 10%): Peripheral neurological symptoms, dizziness
Uncommon (0.1% to 1%): Syncope, peripheral neuropathy, amnesia, somnolence, dysgeusia
Frequency not reported: Paresthesias
Very common (10% or more): Elevated creatine kinase (up to 11%)
Common (1% to 10%): Back pain, myalgia, arthralgia
Uncommon (0.1% to 1%): Muscle atrophy
Rare (less than 0.1%): Myopathy
Frequency not reported: Bone pain, extremity pain, myasthenia, osteonecrosis
Elevated creatine kinase (at least 5.1 times ULN) has been reported in up to 11% of patients.
Common (1% to 10%): Decreased neutrophils, decreased hemoglobin, decreased platelets
Rare (less than 0.1%): Spontaneous bleeding in hemophiliacs
Decreased neutrophils (less than 750 cells/mm3), hemoglobin (less than 8 g/dL), and platelets (less than 50,000 cells/mm3) have been reported in up to 8%, up to 5%, and up to 5% of patients, respectively.
Common (1% to 10%): Fever/pyrexia, pain, fatigue, asthenia, lipodystrophy syndrome
Uncommon (0.1% to 1%): Chest pain, malaise, gait disturbances
Rare (less than 0.1%): Edema
Frequency not reported: Burning sensation, dysplasia, facial atrophy, generalized edema, heat sensitivity, infection, overdose, pallor, peripheral edema, substernal chest pain, sweating, semicircular canal lithiasis
Common (1% to 10%): Depression, insomnia
Uncommon (0.1% to 1%): Anxiety, disorientation, sleep disorder, abnormal dream
Common (1% to 10%): Scleral icterus/ocular icterus
Common (1% to 10%): Increased cough
Uncommon (0.1% to 1%): Dyspnea
In healthy volunteers and patients, abnormalities in AV conduction were asymptomatic and generally limited to first-degree AV block.
A 59-year-old HIV-infected woman with congestive heart failure and an ejection fraction of 30% started lamivudine, zidovudine, and atazanavir (the active ingredient contained in Reyataz) One month later, the patient presented with syncope and complained of nausea, which had begun 5 days prior. During the month after therapy initiation, the patient experienced slowly progressive shortness of breath. An ECG showed a QTc interval prolongation of 619 min. Prior to starting antiretroviral therapy, an ECG showed a QTc interval of 398 min for the patient. The patient developed continuous ventricular tachycardia and was defibrillated to sinus bradycardia, which worsened her QT interval prolongation. The patient developed torsades de pointes, which reverted after further defibrillation. Treatment to increase her heart rate and decrease her QT interval was started. The patient's antiretroviral therapy was discontinued during her hospitalization and was not restarted due to concerns regarding QT prolongation. The patient's QTc interval decreased to 394 min and she had no additional ventricular tachyarrhythmias. The patient was restarted on lamivudine, zidovudine, and atazanavir and within 2 days, ECG showed QTc interval prolongation to 571 min. The atazanavir was concluded to be the cause of the prolonged QT interval and torsades de pointes. The patient's QT interval returned to normal following discontinuation of her antiretroviral therapy.
Uncommon (0.1% to 1%): Hypertension
Rare (less than 0.1%): Palpitation, vasodilatation
Frequency not reported: Prolongation of the PR interval, abnormalities in atrioventricular (AV) conduction, first-degree AV block, prolonged QT interval, ventricular tachycardia, increased QRS interval, heart arrest, heart block, myocarditis
Postmarketing reports: Second-degree AV block, third-degree AV block, left bundle branch block, QTc prolongation, torsades de pointes
Uncommon (0.1% to 1%): Interstitial nephritis
Rare (less than 0.1%): Acute interstitial nephritis, renal colic, reversible acute renal failure, urolithiasis, kidney pain
Postmarketing reports: Nephrolithiasis, hydronephrosis, renal insufficiency
An analysis of a ureteral stone determined it was 60% atazanavir metabolite and 40% calcium phosphate (carbonate apatite). The stone was not metabolites adsorbed into the apatite but contained atazanavir crystals. Analysis of renal calculi from additional patients determined concentrations of atazanavir ranging from 40% to 100%.
Uncommon (0.1% to 1%): Hypersensitivity
Frequency not reported: Allergic reaction
Uncommon (0.1% to 1%): Hematuria, frequency of micturition/pollakiuria, proteinuria, gynecomastia
Frequency not reported: Decreased male fertility
Frequency not reported: Immune reconstitution syndrome, autoimmune disorders in the setting of immune reconstitution (e.g., Graves' disease, polymyositis, Guillain-Barre syndrome)
More about Reyataz (atazanavir)
Consumer resources
Professional resources
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.


text:
- Home
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- Berne
A pile of rubble was all that remained Friday following the demolition of the sweeper shop/Holthouse Drug building in downtown Decatur.
Fleming Excavating spent 12 or so hours of work over a period of two days razing one of the oldest buildings in the city.
Next up is the cleanup, which is expected to take several days.
Some traffic restrictions remain in place.


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Find records of Mary Canan
Find birth, death, marriage, military, and other records of Mary R Canan at Ancestry.com.Search for records
Biography & Family History Add details
Mary R Canan (1898 - 1970) was born on June 29, 1898. She was born into the Canan family.
There are no known marriages or children on file for Mary. Mary died on May 15, 1970 at age 71.
Mary R Canan's last known residence is at Johnstown, Cambria County, Pennsylvania.
This record of Mary R Canan comes from the United States Social Security Death Index. According to information provided to the SSDI, this death record has been verified by a family member of the deceased. This data can be considered very accurate. What is the SSDI?
This look at Mary R Canan's history was created by AncientFaces members Contribute any information you have to connect to the people who know her. Some things we would like to know about Mary's genealogy:
- Where was Mary born?
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You can add or remove people from this genealogy by clicking here.
History of Mary R Canan Add details
- Given name
- Mary
- Surnames
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- Last Known Residence
- Johnstown, Cambria County, Pennsylvania
- Born
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- Female
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You can add details to this page and share Mary's story.
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Possible Relatives
- William Canan
- ·
- Quentin S Canan
- ·
- Rachel Canan
- ·
- Joseph D Canan
- ·
- Russell Canan
- ·
- C L Canan
- ·
- Ida E Canan
- ·
- Mary Canan
- ·
- Katheryn E Canan
- ·
- William Canan
- ·
- Marguerite E Canan
- ·
- Frances L Canan
- ·
- Charles Canan
- ·
- Lawrence Canan
- ·
- H Canan
- ·
- Jessie Canan
- ·
- Hannah v Canan
- ·
- Edward Canan
- ·
- Edwin E Canan
- ·
- Thomas Canan
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Date: 1972-08-09
Description: Two women stuffing a muskellunge with rice at the Musky Jamboree. Both women wear colorful flower print shirts. One woman wears a Boulder Junction Booster...
Date: 1931 ca.
Description: Gene Mayo, 14, poses in front of double doors holding his cap. He is a student at the Mayo School, District No. 1. On the reverse of the photograph is writ...
Date: 1972-05
Description: Spring scene on Wall Street. The building is the Arbutus Inn, hotel, bar and dining room. It was also the original Snowmobile Hall of Fame. Two boys are st...
Description: Tom Simoc, 14, poses with a Guernsey cow near a log barn. On the reverse of the photograph is written, "Won prizes at Co. Fair, 1930." Tom was the son of N...
Date: 1912 ca.
Description: Photographic postcard of a stand of tall trees in the forest at Trout Lake. A hat is hanging on the trunk of a tree in the center.
Date: 1969-01
Description: A snowmobile rider long-jumps at the Eagle River Snowmobile Derby. According to the notes in the photograph album, this was the "world record long jump". T...
Description: Students pose in front of the Mayo School, District No. 1. There are large pine trees around the one-story building and a low fence in front. A "Mayo Schoo...
Date: 1929
Description: Seven pupils graduating from the Mayo School, District No. 1, pose sitting in a row in their classroom. The room has been decorated with flowers, crepe pap...
Date: 1912
Description: Trout Lake Forest Headquarters, the deer corral, with four fawns. Three of the fawns are eating from a trough, the third from a pail held by a man, who may...
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Description: Overnight camping for automobile travelers.
Date: 1972-01
Description: View from behind of group of spectators watching competitors at the World Snowmobile Championship.
Date: 1954
Description: Ten men stand in row in front of a sign marking the 25th anniversary of the Eagle Scout Forestry Camp. They are each holding an Eagle Scout trophy. C.L. (N...
Description: C.L. (Neal) Harrington standing among the pines (Trout Lake?).
Date: 1983 ca.
Description: Men with rakes and wearing waders work knee-deep in water harvesting cranberries on a flooded marsh.
Description: A Chippewa (Ojibwa) mother with two children, one of whom is in a cradleboard, at the Lac du Flambeau reservation. This image is part of an exhibit about...
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Date: 1931
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text:
2014 Winter Weather Predictions For Eastern Kentucky
2014 long range winter forecast | farmers' almanac, What will the coming winter bring? get our long-awaited 2014 forecast!. Nba: 2014 winter forecast -- east standings - espn, These winter forecast predictions are powered by espn forecast. welcome to our winter forecast! with the midseason upon us, we're taking a fresh look at. Eastern weather - accuweather forecast for ky 41622, Get the eastern weather forecast. access hourly, 10 day and 15 day forecasts along with up to the minute reports and videos for eastern, ky 41622 from accuweather.com.
2014 fishing forecast and tips - kentucky department of, 2014 fishing forecast and tips welcome to the 2014 fishing forecast for kentucky's major fisheries. the forecast is based on 2013 fish population surveys, creel. 2013-2014 winter forecast - wkyt | lexington, kentucky, Chief meteorologist shane smith shares his thoughts about the upcoming winter season. how much snow will we see?. The weather centre: final 2013-2014 winter forecast, Hello everyone, this is the final 2013-2014 winter forecast from the weather centre. this post will finalize my projections for this winter, with 3 month.
Winter forecast: not mild, but wild for eastern u.s., Every year, accuweather.com issues a u.s. winter forecast, highlighting predictions of temperature and precipitation trends. last year, winter was unusually warm for. Eastern, ky weather forecast from weather underground, Get the latest forecast for weather in eastern ky along with updates about temperature, humidity, weather radar and more on weather underground.. 2014 long-range weather forecast - old farmers almanac, Find the old farmer's almanac long range weather forecast..


text:
FORT MYERS, FL-What does the month in which you were born say about your driving skills?
One insurance company claims to have used real statistics to find out.
Not everyone agrees with the findings.
Reporter Sarah Pusateri says, "Forget age, or gender, statistics by Allstate show, the likelihood of someone getting into a traffic crash is written in the stars."
Courtney Fuller, an Aquarius says, "Driving doesn't have anything to do with your Zodiac sign."
Oh but it does, says all state who compiled accident statistics and compared them to the birth month of the driver. One Zodiac sign is more accident prone than most.
Sarah Pusateri says to a Virgo man, "I have a survey here from all state that says Virgos are the worst drivers of anyone."
A shocked Virgo replies, "Is that right really?"
According to Allstate, just last year in Florida Virgos wrecked more than 23 thousand times. One man says he doesn't believe it.
"I don't agree with much Allstate has to say."
Some didn't debate the statistics but had other useful knowledge.
"I don't know about Virgos being bad drivers, but you know what they say about Leos? Tell me. Leos are good lovers."
Allstate doesn't have statistics to support that yet, or this.
"I've got one for you guys, if your birth date and how old you are, it's going to add up to 111."
He's right!
"Can I just cut to the chase?"
That is, no matter what your sign, or what statistics say.
No one wants to be called a bad driver.
The best drivers according to Allstate are Scorpios November 23rd- November 28th- 2,855 accidents in 2010
Ophiuchus (the newest sign) November 29-December 17 Wise, ambitiious, lucky- 9,191 accidents in 2010
Cancer July 21st-August 9th Compassion, sensitivity 10, 605- accidents in 2010
Aquarius February 16-March 11 Progressive, independent 11, 505-accidents in 2010
Libra October 31st-November 22 Cooperative, gracious- 11, 981 accidents in 2010
Aires April 17-May 13th Impatience, determination -11,820 accidents in 2010
Capricorn January 18th-February 15th Resonsible, disciplined 13,731-accidents in 2010
Gemini June 20th- July 20th Short attention span, nervous 14, 390-accidents in 2010
Sagittarius December 18-January 17th Impatient, idealistic 16, 704- accidents in 2010
Pisces March 12-April 16th Fearful, overly trusting 17, 841 accidents in 2010
Taurus May 14th-June 19 Uncompromising, possessive 18,867 accidents in 2010
Leo August 10-September 15th Arrogence, inflexibility -19,334 accidents in 2010
Virgo- September 16-October 20th Worry Shyness -23,273 accidents in 2010


text:
DelAgua Group
based in Marlborough, UNITED KINGDOM
The DelAgua kit was first introduced to overcome the problem of lack of access to testing laboratories. It is now used all over the World by both Government and Non-Government Organisations as the Portable Water testing kit of choice.DelAgua also supplies all manner of water testing & laboratory equipment at heavily discounted prices to companies and individuals all over ...
Dragflow S.r.l.
based in Villafranca, ITALY
Dragflow S.r.l. is a world player in solid pumping solutions with over 25 years of experience in manufacturing heavy duty pumps and complete dredging equipments. Dragflow is focused on the continuous development of its design and manufacturing activities for dredging, mining and industrial sectors. With its distribution network around the world Dragflow is able to give ...
Metrohm AG
based in Herisau, SWITZERLAND
Metrohm is a worldwide leading manufacturer of precision instruments for chemical analysis. In the field of electrochemical ion analysis Metrohm has been the unchallenged world number one for many years. This is reflected in the company's comprehensive product range:• pH meters, ion meters, conductometers • Potentiometric, thermometric and Karl Fischer titration• ...
econ industries GmbH
based in Starnberg, GERMANY
Hazardous and industrial waste technologies are our profession. The VacuDry units - a thermal desorption process working with high temperature and lowest vacuum - are state-of-the-art for treating mercury, hydrocarbon, PCB, solvent polluted sludge and soils. We also offer solidification units to stabilise inorganic ashes, dust and sludge as well as sterilising systems ...
ICL Water Solutions - BK Giulini GmbH
based in Ludwigshafen, GERMANY
Water is the most diverse resource we know and it influences many different areas of life. However, it is a sensitive element and cannot be taken for granted.We as ICL Water Solutions use our expertise and decades of experience to take care of water, wherever it is needed for industrial processes or public purposes. ICL Water Solutions is part of BK Giulini GmbH, an ICL ...
REDWAVE systems, a trademark of BT-Wolfgang Binder GmbH
based in Gleisdorf, AUSTRIA
In order to make an efficient use of increasingly scarce raw materials we are developing new opto-electronic recycling technologies called REDWAVE. The REDWAVE guarantees economic operation, high capacity and superior quality in the sorting technology.
Cerex Monitoring Solutions, LLC.
based in Atlanta, GEORGIA (US) (USA)
Cerex Monitoring Solutions develops and manufactures high-tech CEMs, Process, Open Path Ambient and Portable real-time multi-gas monitoring solutions. Providing simple, effective, customized systems for industry, government and the community, Cerex systems have the capability to perform multi-component analysis with a single instrument.
based in Karmiel, ISRAEL
OPGAL Optronics Industries is a leading global manufacturer of innovative thermal imaging safety systems and infrared cameras. OPGAL developed and manufactured the EyeCGas, a fugitive emission detection thermal imager, capable of gas leak detection from a distance of VOC's and other gases. OPGAL offers the widest selection of infrared cooled and uncooled OEM cameras and ...
Pagani Geotechnical Equipment s.r.l.
based in Calendasco, ITALY
SINCE 1978 WE BUILD COMPLETE SYSTEM FOR GEOTECHNICAL SITE INVESTIGATION.That-is-to-say, running accurate measurements with both static and dynamic tests with automatic anchorage of the rig to the ground or with an innovative fastening system on truck.In a word: flexibility guaranteed by an equipment, which can be used by a single man to run CPT, DP, CPTU as well as SCTPU ...
based in Zoppola (Pordenone), ITALY
EVALED evaporators are a Veolia Water Solutions & Technologies Italia's product. Veolia Italia is the technical Italian branch of Veolia Water, the world leader in water treatment and part of the Veolia Environment Group. A specialist in engineering and turnkey design & build projects, Veolia Water Solutions & Technologies also offers a wide range of technological ...


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Micro- and Nano-Transport of Biomolecules
Biological Signal Analysis
About the book
Connie E. Lindell ★★★★★
This is a good reinforcement especially for me that I find Pharmacology quite difficult. It's detailed yet direct to the point that perfectly matches a student's level of understanding.
All the basic concepts of pharmacokinetics (PKs) are described, with an emphasis on understanding what parameters such as bioavailability, volume of distribution and clearance tell us about the behaviour of a particular drug. The use of PKs in both a drug development and a clinical setting are covered. The essential mathematical basis of PKs is explained, but excessive mathematical complexity is avoided. For all key equations, practical examples of their use are provided. There are plenty of practice questions (along with model answers). Additional spreadsheets are provided on the net.
- ADME – Absorption Distribution, Metabolism and Excretion
- Pharmacokinetics
- Passive diffusion and other mechanisms by which drugs may cross biological membranes
- Rate of drug absorption and the Absorption rate constant (Ka)
- Bioavailability
- Salt factor
- The rate of distribution and compartments
- One compartment model
- Two compartment model
- The extent of distribution
- Volume of distribution
- Using the volume of distribution to calculate dose size
- Practice calculations
- Elimination rate constant and half-life
- Clearance
- Practice calculations
- Concentration versus time graph
- Relationship between time and concentration
- Area Under the Curve (AUC)
- Practice calculations
- Appendix 1
- Appendix 2
- Analysis of clinical trials data
- Analysis of data arising in a clinical setting
- Practice calculations
- Appendix 1
- Appendix 2
- The model to be considered
- Drug concentrations in blood and the rest of the first compartment
- Determining how many compartments a drug occupies
- Drug concentration in the second compartment
- Two compartment systems and therapeutic drug monitoring for digoxin
- The model to be considered
- Concentration versus time curve during infusion
- Relationship between rate of infusion and concentration at steady state
- Loading doses
- The accumulation period
- Practice questions
- Appendix
- The situation to be considered
- Concentration versus time curve
- Changing the rate of absorption
- Cmax and Tmax
- Determination of bioavailability for extravascular doses
- Trapezoidal rule – A practical method to measure AUC
- Practice question
- Appendix
- Pharmacokinetic accumulation and steady state
- Multiple extravascular doses
- Concentrations at steady state
- Loading dose
- Accumulation stage
- Extent of fluctuation in drug concentrations
- Practice questions
- Appendix
- Considering drug metabolism as an enzyme catalysed reaction
- Exceptions to linearity
- Effect of non-linearity on the relationship between dose and drug concentration
- Clinical significance of non-linear kinetics
- Non-linear kinetics and drug development
- The case for non-compartmental methods
- Calculation methods
- More complex situations
- Least squares fitting
- Practice question
- Clearance of creatinine and various drugs
- Digoxin dosing
- Practice questions
- Symbols
- Cockcroft and Gault equations
About the Author
Dr Phil Rowe has spent over 30 years teaching quantitative topics relevant to the pharmaceutical sciences – including pharmacokinetics, pharmaceutical/clinical statistics and epidemiology. His speciality is explaining mathematically based topics to the non-mathematically minded, in both a university and a commercial setting.
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