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Publications (118)247.97 Total impact
Article: Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.[Show abstract] [Hide abstract]
ABSTRACT: Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited.JAMA The Journal of the American Medical Association 07/2014; 312(3):249-58. · 29.98 Impact Factor
Article: Anti-HMGCR Autoantibodies in European Patients With Autoimmune Necrotizing Myopathies: Inconstant Exposure to Statin.[Show abstract] [Hide abstract]
ABSTRACT: Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-exposed patients. Here we report what is to our knowledge the first European cohort of patients with NAM.The serum of 206 patients with suspicion of NAM was tested for detection of anti-HMGCR aAb using an addressable laser bead immunoassay. Forty-five patients were found to be anti-HMGCR positive. Their mean age was 48.9 ± 21.9 years and the group was predominantly female (73.3%). Statin exposure was recorded in 44.4% of patients. Almost all patients had a muscular deficit (97.7%), frequently severe (Medical Research Council [MRC] 5 ≤3 in 75.5%). Subacute onset (<6 mo) was noted for most of them (64.4%). Nevertheless, 3 patients (6.6%) had a slowly progressive course over more than 10 years. Except for weight loss (20%), no extramuscular sign was observed. The mean CK level was high (6941 ± 8802 IU/L) and correlated with muscle strength evaluated by manual muscle testing (r = -0.37, p = 0.03). Similarly, anti-HMGCR aAb titers were correlated with muscular strength (r = -0.31; p = 0.03) and CK level (r = 0.45; p = 0.01). Mean duration of treatment was 34.1 ± 40.8 months, and by the end of the study no patient had been able to stop treatment.This study confirms the observation and description of anti-HMGCR aAb associated with NAM. The majority of patients were statin naive and needed prolonged treatments. Some patients had a dystrophic-like presentation. Anti-HMGR aAb titers correlated with CK levels and muscle strength, suggesting their pathogenic role.Medicine 05/2014; 93(3):150-7. · 4.35 Impact Factor
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ABSTRACT: Objectives We studied the clinical phenotypes and tolerance to treatments in a series of patients affected by both inflammatory joint diseases and mastocytosis. Methods This retrospective multicenter study was conducted on behalf of 3 networks, focused on mastocytosis, pediatric and adults' inflammatory joint diseases respectively. Patients who displayed both mastocytosis and inflammatory joint diseases were included. Results Thirty-one patients were included. They had spondyloarthritis (SpA) (16 patients), rheumatoid arthritis (6 patients), juvenile idiopathic arthritis (2 patients), and undifferentiated arthritis (7 patients). The median ages at diagnosis of arthritis rheumatism and mastocytosis were 44 and 40.5 years respectively. Disease-modifying anti-rheumatic drugs (DMARDs) were required in 22 patients, comprising mostly methotrexate (13 patients), salazopyrine (8 patients), anti-tumor-necrosing-factor agents (7 patients) and corticosteroids (9 patients). They were well tolerated. Adverse events occurred in 2/24 patients receiving non-steroidal anti-inflammatory drugs. The prevalence of SpA among the 600 patients included in the mastocytosis cohort was 2.33%, which is significantly higher than the prevalence of SpA in the French population (p< 0.001). Conclusions This study suggests that mastocytosis is associated with a higher prevalence of SpA than expected, and that DMARDs, notably anti-TNFα agents, are well tolerated in patients with mastocytosis. Mast cells might be involved in the development of SpA.Seminars in Arthritis and Rheumatism. 01/2014;
Article: European League Against Rheumatism Sjögren's Syndrome Disease Activity Index and European League Against Rheumatism Sjögren's Syndrome Patient-Reported Index: A Complete Picture of Primary Sjögren's Syndrome Patients[Show abstract] [Hide abstract]
ABSTRACT: Objective The European League Against Rheumatism (EULAR) Sjögren's Syndrome (SS) Disease Activity Index (ESSDAI) and the EULAR SS Patient-Reported Index (ESSPRI) were recently developed. We aimed to determine whether patients' symptoms differed between patients with and without systemic involvement and if the disease-specific indices correlated with each other in primary SS. Methods Fifteen French centers included 395 primary SS patients in the Assessment of Systemic Signs and Evolution in Sjögren's Syndrome Cohort. At enrollment, physicians completed the ESSDAI, the SS Disease Activity Index (SSDAI), and the Sjögren's Systemic Clinical Activity Index (SCAI), and patients completed the ESSPRI, the Sicca Symptoms Inventory, and the Profile of Fatigue and Discomfort. All scores were compared between patients with and without systemic involvement. Correlations between scores of systemic activity and patients' symptoms were obtained. ResultsAt enrollment, 120 (30.4%) patients had never experienced systemic complication and 155 (39.2%) patients and 120 (30.4%) patients had, respectively, only past or current systemic manifestations. Past or current systemic patients had higher levels of symptoms, except dryness. The ESSDAI did not correlate with the patient-scored ESSPRI (rho = 0.06, P = 0.30), whereas the SSDAI and the SCAI, which include subjective items, did correlate (rho = 0.28 and 0.25, respectively; P < 0.0001 for both). Conclusion Alterations of common patient-reported outcomes are present in all patients with primary SS, including those with systemic complications. However, patient symptoms and systemic complications are 2 different facets of primary SS. Therefore, the use of both systemic and patients' indices, such as the ESSDAI and ESSPRI, are useful. Since these 2 facets weakly overlap, one should identify which of both components is the main target of the treatment to test, when designing clinical trials in primary SS.Arthritis Care & Research. 08/2013; 65(8).
Article: Adalimumab for steroid sparing in patients with giant-cell arteritis: results of a multicentre randomised controlled trial.[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the effect of adding a 10-week treatment of adalimumab to a standardised treatment with corticosteroids on the ability to taper more rapidly corticosteroid doses in patients with newly diagnosed giant cell arteritis (GCA). Patients included in this double-blind, multicentre controlled trial were randomly assigned to receive a 10-week subcutaneous treatment of adalimumab 40 mg every other week or placebo in addition to a standard prednisone regimen (starting dose 0.7 mg/kg per day). The primary endpoint was the percentage of patients in remission on less than 0.1 mg/kg of prednisone at week 26. Analysis was performed by intention to treat (ITT). Among the 70 patients enrolled (adalimumab, n=34; placebo, n=36), 10 patients did not receive the scheduled treatment, seven in the adalimumab and three in the placebo group. By ITT, the number of patients achieving the primary endpoint was 20 (58.9%) and 18 (50.0%) in the adalimumab and placebo arm, respectively (p=0.46). The decrease in prednisone dose and the proportion of patients who were relapse free did not differ between the two groups. Serious adverse events occurred in five (14.7%) patients on adalimumab and 17 (47.2%) on placebo, including serious infections in three patients on adalimumab and five on placebo. Two patients died in the placebo arm (septic shock and cancer) and one in the adalimumab group (pneumonia). In patients with newly diagnosed GCA, adding a 10-week treatment of adalimumab to prednisone did not increase the number of patients in remission on less than 0.1 mg/kg of corticosteroids at 6 months. NCT00305539.Annals of the rheumatic diseases 07/2013; · 8.11 Impact Factor
Article: Thalidomide in systemic mastocytosis: results from an open-label, multicentre, phase II study.[Show abstract] [Hide abstract]
ABSTRACT: Mastocytosis can lead to organ failure as well as systemic symptoms that can be disabling, with considerable deterioration in quality of life. Beside symptomatic treatments, interferon-α and purine analogues have been shown to be effective but complete or long-term remission is rarely obtained with these drugs. We conducted a phase II, multicentre, study to investigate thalidomide in severely symptomatic indolent and aggressive systemic mastocytosis. Twenty patients were enrolled of whom 16 were analysed for response. The overall response rate was 56%. Responses were observed in the skin in 61% of patients with a significant decrease in the pruritus score. Mast cell mediator-related symptoms responded in 71% of cases and 25% of aggressive systemic mastocytosis patients had a response in terms of B/C findings (borderline/cytoreduction needed). Bone marrow mast cell infiltration decreased in five of the eight evaluable patients. There was no significant improvement in the AFIRMM (Association Française pour les Initiatives de Recherche sur le Mastocyte et Les Mastocytoses), Quality of Life or Hamilton scores. Grade 3-4 toxicities consisted of peripheral neuropathy (11%) and myelosuppression (neutropenia: 5%; thrombocytopenia: 11%). In conclusion, thalidomide might be useful in mastocytosis and in the treatment of mast cell-related symptoms. It might be considered in selected patients, taking into account the benefit/risk balance and the individual patient evaluation.British Journal of Haematology 02/2013; · 4.94 Impact Factor
Article: Q fever and Mediterranean spotted fever associated with hemophagocytic syndrome: case study and literature review.[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Hemophagocytosis during Q fever (QF) and Mediterranean spotted fever (MSF) is rare and only a few cases have been reported. We aimed to investigate the characteristics, outcome, and treatment of QF/MSF-associated hemophagocytosis. METHODS: We retrospectively reviewed all patients with a diagnosis of QF or MSF and suspected hemophagocytic syndrome (HS), according to Henter's criteria, between 2002 and 2011, and compared the latter to patients without HS or with lymphoma-associated HS. RESULTS: Seventeen patients with HS (median age 42 years, range 5-68 years; five females (29%)) with QF (n=8) and MSF (n=9) were included in this study. When comparing patients with QF- and MSF-associated HS with patients without HS (n=11), HS-associated signs (splenomegaly, ferritinemia, hypertriglyceridemia, and cytopenia) were significantly more frequent in patients with histological HS (p<0.05), along with a greater number of Henter's criteria. Despite the presence of HS-associated signs, treatment was similar in these two subgroups, including the time to recovery and the outcome. When compared to lymphoma-associated HS (n=10), the outcome in QF/MSF-associated HS was significantly different, with mortality in 70% of lymphoma patients versus none in QF- and MSF-associated HS (p<0.05). CONCLUSION: Hemophagocytosis is a rare occurrence during the course of QF and MSF. The presence of profound cytopenia is quite unusual in QF and MSF and should bring to mind the presence of associated HS. Nevertheless, hemophagocytic syndrome is associated with a good outcome in this condition.International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 02/2013; · 2.17 Impact Factor
Article: Serum Levels of Beta2-Microglobulin and Free Light Chains of Immunoglobulins Are Associated with Systemic Disease Activity in Primary Sjögren's Syndrome. Data at Enrollment in the Prospective ASSESS Cohort.[Show abstract] [Hide abstract]
ABSTRACT: To analyze the clinical and immunological characteristics at enrollment in a large prospective cohort of patients with primary Sjögren's syndrome (pSS) and to investigate the association between serum BAFF, beta2-microglobulin and free light chains of immunoglobulins and systemic disease activity at enrollment. Three hundred and ninety five patients with pSS according to American-European Consensus Criteria were included from fifteen centers of Rheumatology and Internal Medicine in the "Assessment of Systemic Signs and Evolution of Sjögren's Syndrome" (ASSESS) 5-year prospective cohort. At enrollment, serum markers were assessed as well as activity of the disease measured with the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI). Patient median age was 58 (25(th)-75(th): 51-67) and median disease duration was 5 (2-9) years. Median ESSDAI at enrollment was 2 (0-7) with 30.9% of patients having features of systemic involvement. Patients with elevated BAFF, beta2-microglobulin and kappa, lambda FLCS had higher ESSDAI scores at enrollment (4 [2]-[11] vs 2 [0-7], P = 0.03; 4 [1]-[11] vs 2 [0-7], P< 0.0001); 4 [2]-[10] vs 2 [0-6.6], P< 0.0001 and 4 [2-8.2] vs 2 [0-7.0], P = 0.02, respectively). In multivariate analysis, increased beta2-microglobulin, kappa and lambda FLCs were associated with a higher ESSDAI score. Median BAFF and beta2-microglobulin were higher in the 16 patients with history of lymphoma (1173.3(873.1-3665.5) vs 898.9 (715.9-1187.2) pg/ml, P = 0.01 and 2.6 (2.2-2.9) vs 2.1 (1.8-2.6) mg/l, P = 0.04, respectively). In pSS, higher levels of beta2-microglobulin and free light chains of immunoglobulins are associated with increased systemic disease activity.PLoS ONE 01/2013; 8(5):e59868. · 3.53 Impact Factor
Article: Efficacy of rituximab in systemic manifestations of primary Sjogren's syndrome: results in 78 patients of the AutoImmune and Rituximab registry.[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVES: To evaluate the efficacy and safety of rituximab in patients with primary Sjögren's syndrome (pSS). METHODS: The AutoImmune and Rituximab registry has included 86 patients with pSS treated with rituximab, prospectivey followed up every 6 months for 5 years. RESULTS: Seventy-eight patients with pSS (11 men, 67 women), who already had at least one follow-up visit, were analysed. Median age was 59.8 years (29-83), median duration of disease was 11.9 years (3-32). Indications for treatment were systemic involvement for 74 patients and only severe glandular involvement in four patients. The median European Sjögren's Syndrome disease activity index (ESSDAI) was 11 (2-31). 17 patients were concomitantly treated with another immunosuppressant agent. Median follow-up was 34.9 months (6-81.4) (226 patient-years). Overall efficacy according to the treating physician was observed in 47 patients (60%) after the first cycle of rituximab. Median ESSDAI decreased from 11 (2-31) to 7.5 (0-26) (p<0.0001). Median dosage of corticosteroid decreased from 17.6 mg/day (3-60) to 10.8 mg/day (p=0.1). Forty-one patients were retreated with rituximab. Four infusion reactions and one delayed serum sickness-like disease resulted in rituximab discontinuation. Three serious infections (1.3/100 patient-years) and two cancer-related deaths occurred. CONCLUSIONS: In common practice, the use of rituximab in pSS is mostly restricted to patients with systemic involvement. This prospective study shows good efficacy and tolerance of rituximab in patients with pSS and systemic involvement.Annals of the rheumatic diseases 12/2012; · 8.11 Impact Factor
Article: Rituximab in central nervous system manifestations of patients with primary Sjögren's syndrome: results from the AIR registry.[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the efficacy of rituximab in central nervous system (CNS) manifestations of patients with primary Sjögren's syndrome (pSS). Prospective data from patients with pSS and CNS involvement included in the French AutoImmunity and Rituximab registry were analysed. All patients had diffuse white matter T2-weigted hypersignals. Neurological response was defined as improvement or disappearance of neurological signs. Eleven patients (mean age 55 years [38-77]) were treated with rituximab for their neurological involvement. The mean duration of pSS was 9 years (4-24). Mean baseline ESSDAI score was 17 (5-25). Neurological features were progressive multiple sclerosis-like manifestations (n=6), transverse myelitis (n=1), anxiety and depression disorder (n=1) and cognitive dysfunction (n=3). Mean Expanded Disability Status Score (EDSS) before rituximab was 4 (3-5.5). The mean follow-up was of 13 months (6-58). No neurological change occurred in all 6 patients with multiple sclerosis-like symptoms, in 2/3 patients with cognitive dysfunction or in the patient with anxiety-depression. One patient with depression and cognitive dysfunction disclosed subjective improvement. One patient with transverse myelitis, refractory to cyclophosphamide had an improvement of his walk perimeter (160 meters vs. 116). Mean EDSS score and ESSDAI remained stable. Rituximab does not seem to be effective in progressive multiple sclerosis-like manifestations of patients with pSS-related CNS involvement.Clinical and experimental rheumatology 02/2012; 30(2):208-12. · 2.66 Impact Factor
Article: [Management of orbital inflammation in internal medicine: a retrospective case series of 29 patients].[Show abstract] [Hide abstract]
ABSTRACT: To describe a case series of patients investigated in internal medicine for an inflammation of the orbit and to clarify the clinical and pathological features of patients with idiopathic orbital inflammatory syndrome (IOIS). Forty patients were consecutively referred by a specialized center where an orbital biopsy was performed in case of accessible lesion. Eleven patients were excluded because of missing data or diagnosis of lymphomas, periorbital xanthogranulomas, or Graves' disease. Patients with systemic disease (SD) or auto-immune disorder (AID) that validated the international criteria, or those having an IOIS in the absence of local or systemic etiology, were included. The clinicopathologic and immunologic characteristics of IOIS patients, their treatment and their evolutionary profiles are reported according to the histological types described by Mombaerts. Of the 29 patients enrolled, eight had a dacryoadenitis revealing a SD/AID, mainly a necrotizing vasculitis, seven patients had a presumed IOIS and 14 an IOIS histologically documented. The presentation of IOIS was dominated by a diffuse involvement of the orbit. Corticosteroids were administered alone or with an immunosuppressant in 57 and 24% of IOIS patients, respectively. The incidence of relapse/resistance was higher than that of remission, particularly in case of presumed IOIS or in its classical form. All four patients with a stage III-IV of Chisholm were relapsing or resistant. A dacryoadenitis may reveal some types of SD/AID. Unlike the severe sialadenitis, the form of sclerosing IOIS may not be a factor associated with relapse or resistance.La Revue de Médecine Interne 01/2012; 33(2):69-75. · 0.90 Impact Factor
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ABSTRACT: Vascular manifestations of Cogan's syndrome are rarely reported. We report the case of a young woman followed for typical Cogan's disease. Serious vascular involvement was found only during work-up for arterial hypertension. This case highlights potentially asymptomatic nature of extensive vasculitis affecting large and medium-sized vessels in Cogan's disease. Careful screening is required to prevent life-threatening complications.Journal des Maladies Vasculaires 12/2011; 37(1):19-21. · 0.24 Impact Factor
Article: Efficacy and safety of rituximab in the treatment of refractory inflammatory myopathies in adults: results from the AIR registry.[Show abstract] [Hide abstract]
ABSTRACT: To assess the efficacy and safety of rituximab (RTX) in patients with refractory idiopathic inflammatory myopathies (IIMs). RTX efficacy was based on improvement in three criteria: creatine phosphokinase (CPK) level, daily CS dose and physicians' opinion. A decrease in CPK level or CS dose was significant if it was >25%. Thirty patients were studied (21 women; age 52.5 years, disease duration 6.1 years). All had previously received immunosuppressors (ISs). Twenty-five patients received 1 g of RTX twice 2 weeks apart and five received 4 weekly RTX infusions (375 mg/m(2)). RTX was given in association with IS in 21 patients. Twenty-eight patients received CS (mean dose 21.2 mg/day). Mean follow-up was 17.2 months. Thirteen adverse events were reported, including seven infections and one serious infection (pyelonephritis). RTX was effective in 16 patients. Duration of efficacy was 15.5 months. Of the 20 patients with baseline CPK level ≥2 × upper limit of normal (ULN), 11 (55%) improved. The main level fell from 20.7 to 11 × ULN. CS decreased in 15 patients, stopped in 4, remained stable in 8 and increased in the remaining 3. The CS dose decreased from 21.2 to 9.9 mg/day. The physicians' opinion was favourable in 21 patients. Manual muscle testing was performed in only five patients: it increased from 87 to 91/100 at 6 months. RTX was well tolerated and had some beneficial effects on patients with IIM, the main limitation of this study resulted in a lack of manual muscle testing.Rheumatology (Oxford, England) 12/2011; 50(12):2283-9. · 4.24 Impact Factor
Article: Efficacy and safety of rituximab in common variable immunodeficiency-associated immune cytopenias: a retrospective multicentre study on 33 patients.[Show abstract] [Hide abstract]
ABSTRACT: Patients with common variable immunodeficiency (CVID) are at high risk of developing immune thrombocytopenia (ITP) and/or autoimmune haemolytic anaemia (AHA). Given their underlying immunodeficiency, immunosuppressive treatment of these manifestations may increase the risk of infection. To assess efficacy and safety of rituximab in patients with CVID-associated ITP/AHA, a multicentre retrospective study was performed. Thirty-three patients, 29 adults and four children, were included. Patients received an average of 2·6 treatments prior to rituximab including steroids, intravenous immunoglobulin and splenectomy (21%). The median ITP/AHA duration at time of first rituximab administration was 12 months [range 1-324] and the indication for using rituximab was ITP (22 cases), AHA (n = 5) or both (n = 7); 1 patient was treated sequentially for ITP and then AHA. The overall initial response rate to rituximab was 85% including 74% complete responses. After a mean follow-up of 39 ± 30 months after rituximab first administration, 10 of the initial responders relapsed and re-treatment with rituximab was successful in 7/9. Severe infections occurred after rituximab in eight adults (24%), four of whom were not on immunoglobulin replacement therapy. In conclusion, rituximab appears to be highly effective and relatively safe for the management of CVID-associated severe immune cytopenias.British Journal of Haematology 11/2011; 155(4):498-508. · 4.94 Impact Factor
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ABSTRACT: The aims of this present study were to: 1) assess the characteristics of hematological malignancies in polymyositis/polymyositis (PM/DM) patients; and 2) determine predictive variables of hematological malignancies in PM/DM patients. We retrospectively reviewed the medical records of 32 patients (14 PM, 18 DM) associated with hematological malignancies. In our 32 PM/DM patients, hematological malignancy was concurrently identified (18.8%) or occurred during the course of PM/DM (31.2%); although, PM/DM more often preceded hematological malignancy onset (50%). We observed that the types of hematological malignancies varied, consisting of: B-cell lymphoma (n=20), T-cell lymphoma (n=4), Hodgkin's disease (n=2), multiple myeloma (n=1), myelodysplastic syndrome without excess of blasts (n=3), hairy cell (n=1) and acute lymphocytic leukemia (n=1). In 21 patients of our 32 patients with PM/DM-associated hematological malignancy (65.6% of cases), PM/DM paralleled the course of hematological malignancy. Finally, we observed that patients with PM/DM-associated hematological malignancies had a poor prognosis, the survival status ranging from 96.9%, 78.1% and 51.4% at 1, 3 and 5years, respectively. Interestingly, we found that patients with hematological malignancies, compared with those without were older and more frequently had DM; on the other hand, these patients less commonly exhibited: joint involvement (p=0.017), interstitial lung disease (p=0.06) and anti-Jo1 antibody (p=0.001). Taken together, our study underscores that the association between PM/DM and hematological malignancy, especially lymphoma, should not be ignored. Our findings also suggest that antisynthetase syndrome may be a protective factor of hematological malignancy in PM/DM patients.Autoimmunity reviews 10/2011; 11(9):615-20. · 6.37 Impact Factor
Article: Efficacy of rituximab in primary Sjogren's syndrome with peripheral nervous system involvement: results from the AIR registry.[Show abstract] [Hide abstract]
ABSTRACT: To evaluate rituximab (RTX) in primary Sjögren's syndrome (pSS) with peripheral nervous system (PNS) involvement. Patients with pSS and PNS involvement who were included in the French AIR registry were analysed. 17 patients (age 60 years (44-78 years); 14 were female) were analysed. Neurological improvement was noted in 11 patients (65%) at 3 months. Rankin scale decreased from 3 (1-5) to 2 (1-5), 2 (1-5) and 2 (1-6) after 3, 6 and 9 months (p=0.02). European Sjögren's Syndrome Disease Activity Index decreased from 18 (10-44) to 11 (5-20), 11 (5-29) and 12 (5-30) after 3, 6 and 9 months (p<0.05). RTX was effective in neurological involvement in 9/10 patients with vasculitis or cryoglobulinaemia (90%) (group 1) at 3 months and in 2/7 cases (29%) without cryoglobulinaemia and vasculitis (p=0.03). Rankin and European Sjögren's Syndrome Disease Activity Index scales decreased significantly in group 1. RTX seems effective in cryoglobulinaemia or vasculitis-related PNS involvement in pSS.Annals of the rheumatic diseases 09/2011; 71(1):84-7. · 8.11 Impact Factor
Article: Prevalence and clinical significance of Küpffer cell hyperplasia with hemophagocytosis in liver biopsies.[Show abstract] [Hide abstract]
ABSTRACT: Hemophagocytic syndrome (HS) is a rare life-threatening condition due to uncontrolled macrophagic activation. Liver involvement is constant in HS, characterized by Küpffer cell hyperplasia with hemophagocytosis. Conversely, the specificity, frequency, and clinical significance of this histologic lesion remain poorly investigated. We aimed to evaluate the prevalence of this elementary lesion in liver biopsies (LB) to attempt to identify its clinical significance and to investigate its potential association with perforin expression deficiency. Küpffer cell hyperplasia with hemophagocytosis has been systematically searched for in consecutive LBs in a 6-year period. In positive cases, clinical, biological, and outcome characteristics have been retrospectively recorded. The ratio of perforin to CD3(+) lymphocytes was assessed on immunostained LB sections. This histologic lesion was detected in LB of 69 of 5194 patients (1.3%). It was not associated with hepatotropic viral infection, alcohol-related chronic liver disease, or autoimmune chronic liver disease. Although only 36% of patients with this histologic lesion had a complete HS (association of fever, splenomegaly, bicytopenia, hypertriglyceridemia, hyperferritinemia, and/or hypofibrinogenemia), almost all patients had similar underlying diseases (human immunodeficiency virus infection, malignant hemopathy, and autoimmune disease) and/or acute ongoing infections (tuberculosis, cytomegalovirus, and Epstein-Barr virus). A decrease of the perforin to CD3(+) lymphocytes ratio was specifically associated with this lesion. Küpffer cell hyperplasia with hemophagocytosis in LB is a rare finding; although it does not necessarily denote a complete HS, it is associated with the same underlying disease and/or infection, with a decrease in intrahepatic perforin-positive lymphocytes.The American journal of surgical pathology 03/2011; 35(3):337-45. · 4.06 Impact Factor
Article: Safety and efficacy of rituximab in nonviral cryoglobulinemia vasculitis: data from the French Autoimmunity and Rituximab registry.[Show abstract] [Hide abstract]
ABSTRACT: Management of nonviral cryoglobulinemia vasculitis has yet to be defined. Rituximab has emerged as a novel and promising therapeutic alternative, but data are scarce. Our objective was to evaluate the safety and efficacy of rituximab in nonviral cryoglobulinemia vasculitis in off-trial real-life patients. Prospective data from the French AutoImmunity and Rituximab (AIR) registry, which includes data on patients with autoimmune disorders treated with rituximab in off-label conditions, were analyzed. Twenty-three patients received treatment with rituximab for cryoglobulinemia vasculitis. Tolerance was marked by the occurrence of side effects in almost half of the patients, including severe infections in 6 (26%) of 23, with a rate of 14.1 per 100 patient-years. These infections occurred in a particular subset of patients ages>70 years, with essential type II mixed cryoglobulinemia and renal failure with a glomerular filtration rate of <60 ml/minute, and receiving high-dose corticosteroids. Three of these patients died. In contrast, clinical and immunologic efficacy was noted in all evaluable patients. Clinical relapses occurred in half of the patients after a median time of 13.5 months following rituximab administration, and were more frequent in patients refractory to previous immunosuppressive therapy than in previously untreated patients. Data from the AIR registry show a dramatic efficacy and a steroid-sparing effect of rituximab, but also show the occurrence of severe infections in elderly patients with renal failure and high-dose steroids. The role of rituximab in nonviral cryoglobulinemia vasculitis remains to be defined in well-designed randomized controlled trials.Arthritis care & research. 12/2010; 62(12):1787-95.
Article: Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registry.[Show abstract] [Hide abstract]
ABSTRACT: A number of open-label studies have suggested the potential benefit of rituximab (RTX) in systemic lupus erythematosus (SLE). However, in 2 recent randomized controlled trials (RCTs) of RTX, the primary end points were not met. We undertook this study to evaluate the safety and efficacy of RTX in off-trial patients with SLE seen in regular clinical practice. We analyzed prospective data from the French AutoImmunity and Rituximab (AIR) registry, which includes data on patients with autoimmune disorders treated with RTX. One hundred thirty-six patients received treatment for SLE. The mean +/- SD score on the Safety of Estrogens in Lupus Erythematosus: National Assessment (SELENA) version of the SLE Disease Activity Index (SLEDAI) was 11.3 +/- 8.9 at baseline. Severe infections were noted in 12 patients (9%), corresponding to a rate of 6.6/100 patient-years. Most severe infections occurred within the first 3 months after the last RTX infusion. Five patients died, due to severe infection (n = 3) or refractory autoimmune disease (n = 2). Overall response was observed in 80 of 113 patients (71%) by the SELENA-SLEDAI assessment. Efficacy did not differ significantly between patients receiving RTX monotherapy and those receiving concomitant immunosuppressive agents (who had higher baseline disease activity). Articular, cutaneous, renal, and hematologic improvements were noted in 72%, 70%, 74%, and 88% of patients, respectively. Among responders, 41% experienced a relapse of disease, with a response in 91% after retreatment with RTX. Data from the AIR registry show a satisfactory tolerance profile and clinical efficacy of RTX in patients with SLE. The contrasting results with those from recent RCTs leave open the question of the therapeutic use of RTX in SLE. Additional controlled studies with new designs are needed to define the place of RTX in the therapeutic arsenal for SLE.Arthritis & Rheumatology 08/2010; 62(8):2458-66. · 7.48 Impact Factor
Article: Traitement par immunoglobulines intraveineuses des syndromes d'activation macrophagique d'étiologie infectieuse : analyse de 32 casRevue De Medecine Interne - REV MED INTERNE. 01/2010; 31.
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French Institute of Health and Medical ResearchLutetia Parisorum, Île-de-France, France
Université Paris-Sud 11Orsay, Île-de-France, France
Unité Inserm U1077Caen, Lower Normandy, France
Centre Hospitalier Universitaire RouenRouen, Upper Normandy, France
Université Paris 13 NordÎle-de-France, France
Hôpital Avicenne – Hôpitaux Universitaires Paris-Seine-Saint-DenisBobigny, Île-de-France, France
Centre Médico Chirurgical Paris VLutetia Parisorum, Île-de-France, France
Assistance Publique – Hôpitaux de ParisLutetia Parisorum, Île-de-France, France
Hôpital FochLutetia Parisorum, Île-de-France, France
Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
Paris, Ile-de-France, France
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"Showing without force."
USA 18-May-2001UK N/AAustralia 28-Jul-2001
Directed by
Stanley Kwan
Written by
Jimmy Ngai
Li Huatong
Jun Hu
Shuang Li
Fang Lu
Jin Su
Liu Ye

subset: commoncrawl


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Forum topics mossjon participated in
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The Easiest Pizza You'll Ever Make Rating: 5 Recommend: Y Comments: I cut this recipe in half and it worked very well. It's just my husband and I s...


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November 26, 2014
Posted Friday, June 14, 2013 --- 11:06 a.m.
Sauk Co. deputies say an adult novelty store has been selling synthetic marijuana.
Deputies executed a search warrant Thursday at Cupid's Novelties and Lingerie in the Township of Delton.
Deputies say they found a large amount of synthetic marijuana being sold as "Potpourri."
Authorities also seized drug paraphernalia they say was used for smoking the synthetic marijuana, along with cash and other documents.
Paul Synder and Jerry Davis are scheduled to appear in court next month for "Possession with Intent to Distribute a Hazardous Substance."
Deputies say abuse of synthetic marijuana can cause a variety of severe health problems, including exhaustion, hallucination, increased heart rate, body over-heating, seizures, hospitalization, suicidal tendencies and death.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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Cdc – 2013-2014 flu season | seasonal influenza (flu), Seasonal influenza (flu) 2013-2014 flu season. vaccine selection; what you should know; influenza – flu basics. key facts about seasonal flu; influenza viruses.
Farmers' almanac – official site, Farmers' almanac provides free long range weather forecasts, home and garden advice, astronomy and full moon information, natural cures and cooking..
Health news & articles | healthy living – abc news, Get the latest health news from dr. richard besser. here you'll find stories about new medical research, the latest health care trends and health issues that affect.
Norovirus : cruise law news, Cruise law news : maritime lawyer & attorney : james m. walker : walker & o'neill law firm : admiralty law, cruise ship accidents & injuries published by.
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Test your winter stomach bug iq: 6 facts and myths of norovirus, Winter is the season for norovirus! norovirus is a virus that's the most common cause of "stomach flu," or gastroenteritis. it strikes fast; those with it.
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Draftexpress – nba draft, ncaa/international basketball website., Julius randle has been dominant at times nine games into his freshman season, averaging 18 points and 12 rebounds per contest thus far, shooting 55% from 2-point.


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Here in the Heartland, you know the natives, because they are well acquainted with "bars". Not the booze-drinking bars, but the neighborhood friendly cookie "bar". Wikipedia gives this description of a "bar"… consisting of batter or other ingredients that are poured or pressed into a pan (sometimes in multiple layers), and cut into cookie-sized pieces after baking. Bars are something you take to a social gathering, to an ailing neighbor, a church potluck or to a new mom just home from the hospital. The advantage of baking bars, is that to make them look nice on a plate, you need to slice off a thin edge all the way around the pan, and then these are free for the nibbling!
Several weeks ago, I purchased some Medjool dates, just because it is something that I had never purchased before! I knew that they are naturally high in sugar, so I thought I could come up with a dessert bar without having to add refined sugar. After tweaking a few recipes, I came up with this one! I began by pitting and chopping 1 c. of dates.
After gathering the rest of the ingredients, I started whisking and stirring.
In a small bowl, whisk eggs, oil, honey and vanilla.
In a separate bowl, whisk dates with almond flour. This took a few extra tools, because I tried to separate the chopped dates so they weren't in one big hunk. Add salt, baking soda and walnuts. Stir into egg mixture.
Lay a piece of parchment paper in an 8×8 pan. Spray oil lightly over paper, then spoon mixture over paper, smoothing it out into the corners. This is a great way to keep the dough from sticking to the edges! (Saves on washing dishes too!)
Bake in 350 oven for 20-25 minutes. Remove from heat.
Let set in pan for about 10 minutes, then remove by lifting on the parchment paper. Cool for at least 30 minutes, then slice into desired sizes.
These look good enough for a ladies tea, however my honey keeps snitching them out of the freezer, so they must be good enough for a manly man too!
Walnut Date Dessert Bars
1/1/2 c. flour (I used almond flour to make these gluten free)
1/2 t. baking soda
1/4 t. salt
3 eggs
1/4 c. light olive oil
1/4 c. raw honey
1 T. vanilla
1 c. chopped walnuts
1 c. chopped dates
Mix dry ingredients together, making sure the dates are well distributed and not clumped together. Whisk eggs, oil, honey and vanilla together. Stir into dry ingredients. Lay a piece of parchment paper in an 8×8 pan, with an inch or so overhanging pan. Lightly spray with oil. Spoon dough into pan, smoothing into each corner. Bake in 350 oven for 20-25 minutes. Remove from heat and let set for 10 minutes. Then bars out of pan using the parchment paper. Cool for 30 minutes before slicing into desired sizes.


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Information on the HS&E test, as well as health & safety training and publications
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Sunday, November 7, 2010
Culinary Adventures
6 comments :
- Elisa @ What the Vita said...
Haha! Definitely a foodie in the making - he looks so happy!
- Sunday, November 07, 2010
- christine, just bella said...
Haha, how cute! 'A+' for effort, right?
- Sunday, November 07, 2010
- Katherine said...
These are so cute !! If you're going to put up the "first-taste-of-food" face, you have to put up the first "I-don't-like-it" face. Those are classics...
- Sunday, November 07, 2010
- Sara @ Russet Street Reno said...
Adorable! Pretty soon you will have to feed him naked, when he realizes how fun it is to throw his food.
- Sunday, November 07, 2010
- Jennifer said...
Have been reading your blog for a few months...your basement renovations and nursery are fantastic. Our house is of similiar size, gave me some great ideas. Your sweet baby is adorable.....I'll keep on reading. Jennifer from inieandione.com
- Sunday, November 07, 2010
- Megan {Honey We're Home} said...
Love your little guy!!
- Monday, November 08, 2010
Subscribe to: Post Comments ( Atom )


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Cucumber Water
Prep Time: 3 minutes
Cook Time:
Servings: 8
This is a cool and refreshing alternative to water. Add a few lemon slices for a citrus twist.
2 cups ice
4 cups cold water
1/4 cup cucumber, peeled and sliced
Place the ice into the pitcher and lay sliced cucumbers on top of ice. Pour the water on top of the cucumbers and let it sit for about 1 hour before serving. Fresher cucumbers are best. To re-make, just pour water on top of the cucumber bed.


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Featured Entry
Food Fun
See what we mean about girls and ice cream?
Since the beginning of time and MTV, musicians have known that food translates well into videos - get a sexy girl in...
Gastronomic Gatherings
Maybe you can buy her a drink this week.If you're a pilot or flight attendant or just have a thing for little tiny liquor bottles and airplanes, come out to...
Truck Tracker
Health Hazard
Allergic to peanuts? Zap 'em with UV rays!Are you tired of signs everywhere saying "This cookie/ice cream/coffee/hamburger/goat stew has been processed in a plant that uses peanuts"?
So are we, which is...
B.C. Tacos is heading out to Broward County this weekend.If you love the south Florida food truck scene but hate the drive down to Miami (with gas prices hitting close...
Restaurant Opening
All photos by Laine Doss
The City Hall main dining roomCity Hall, the planned Biscayne Boulevard restaurant, missed its April opening date. Driving by yesterday, we saw a light on...so we...
Favorite Dishes
Restaurant News
Conan O'Brien beat his pork too hard on last night's show.On last night's Conan, Top Chef Masters Aussie hunk, Curtis Stone, tried to teach Conan how to score on date...
Booze Hound
Whole Foods Market
The WFM Wine Guys will be at Coral Springs to taste...and tweet!This Thursday, June 9th, you can taste...and tweet featured summer wines at Whole Foods Market in Coral Springs with...
Restaurant Closings
Emeril Lagasse will close his South Beach restaurant...but will be back for the South Beach Wine & Food FestivalEmeril's Miami Beach, the southernmost outlet of Chef Emeril Lagasse's restaurant empire,...
Chef on the Small Screen


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2013: Participated in eight games … Registered a total of four shots with one on goal.
Prep: Four-year letterwinner at Marana High School … Team captain junior and senior years … Team's Most Valuable Player both junior and senior years … First-team all-city as a junior and senior … First-team all-state as a senior, second-team all-state as a sophomore and junior and honorable mention as a freshman … Led team to two-time state semifinals … Played club for Tucson Soccer Academy … Honor Roll student.
Personal: Daughter of Salvador Pimienta and Alicia Hernandez … Has one brother, Marlon and two sisters, Priscilla and Estefania.


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CSS with IO EchoFine Line Music Cafe, MinneapolisTuesday, June 25, 2013"Let's rule this place with lots of love and respect and hair!" Lovefoxxx exclaimed Tuesday night as she was brushing her Morticia Adams-like wig out of her face. She sure did rule the place. The lead singer of the Brazilian band ... More >>
Jennifer JespersonPeter Jesperson's resume includes stints with Oar Folkjokeopus (now Treehouse Records), Jay's Longhorn Bar, Rev 105, and myriad other music-related jobs. Perhaps best known for co-founding Twin/Tone Records with Paul Stark and Charley Hallman, Jesperson signed such seminal ... More >>
'Cannibalism' director Lizzie Borden feeds on her own extremities


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Posts Tagged 'church'
5 Ways To Improve Your Church YouTube Channel
There's no question that a great number of churches and ministry organizations should be addressing today's "Digital Mission Field." And one of the key platforms is YouTube. Most churches just think YouTube is for randomly posting short video clips of the pastor's message. So I asked my friend Sean Cannell, to give us some examples of how churches and ministry groups can use YouTube more effectively. Here's what he said: Read the full article »
Leaders: The Problem With Valuing Everyone Equally
The Bible is clear – everyone has intrinsic value and worth. God loves us all and there are no favorites in His kingdom. As leaders, we try to live that out every day. The problem is, we get into trouble when we use that principle when evaluating our team. Every church, ministry, nonprofit, or business has employees or volunteers, and while we should appreciate them all equally, some of those employees bring greater value to the table. Throughout the Bible, God chose different people for Read the full article »
Are "Honorary" Doctorates Real Academic Degrees?
When it comes to overblown titles, one thing that's rampant in the Christian world (besides mail order degrees) are pastors and other leaders using honorary doctorates as if they were actual Ph.D. degrees. In case you were wondering – authoritative sources say they shouldn't. While there are only a few instances I could find of written policies such as this one from Brandeis University, many, many university presidents, and highly regarded professors agree: Read the full article »
People are More Valuable Than Technology
I was reading in 2 Kings 12:13-15: "The money brought into the temple was not spent for making silver basins, wick trimmers, sprinkling bowls, trumpets or any other articles of gold or silver for the temple of the Lord; it was paid to the workmen, who used it to repair the temple. They did not require an accounting from those to whom they gave the money to pay the workers, because they acted with complete honesty." It's interesting that the writer actually Read the full article »
Adultery And The Power of a Glass Door
Over the last year, there's been a rash of pastors and other Christian leaders stepping down because of moral failings – usually infidelity. Years ago, I met a pastor in Chicago who was serious about preventing anyone on his staff from engaging in immoral behavior on the job, so he made a brilliant decision – install glass doors in every office in the church. The fact is, Read the full article »
How To Tell Your Project is Failing
Business, nonprofit, and church leaders across the country invest in new projects everyday. The level of risk varies, but one thing is common to all – at some point, the leader needs to make a decision to stay in for the long haul, or cut the losses and call it quits. The problem is – how do you know if your project is in trouble? What are the key indicators that something serious is going wrong? Read the full article »
Why Your Boss Is The Key To Your Future
At some point or another, everyone has boss problems. I've worked for bosses who were the owner's son or daughter, and were completely incompetent. There are fine leaders out there who are second generation, but in my career, I've worked for some real losers. I've had other bosses that were insecure, others who were egomaniacs, and still others who wanted to be somewhere else. As a result, sooner or later, most employees dream of Read the full article »
Porn's Frightening Impact on the Media Industry
Way back in 2006, the Los Angeles Times tracked the impact of the pornography industry on the emerging technology of the time. I've written before on the history of the battle between industry giants VHS and Betamax, back in the early days of home video. Back then, when home video was new, someone could purchase an X-rated video on the phone, and have it mailed to his doorstep in a plain, brown wrapper. For the first time, you could purchase sexually explicit videos without being seen publicly, and the industry literally Read the full article »
Shocking News About Complainers
You'd be surprised at how many times I start working with a new client, only to have someone on their team pull me aside to complain about how the organization is run, or the incompetent leadership, or the mission. I know other people who constantly complain about their job, co-workers, schedule, and more. The bottom line is that there are far too many people complaining and not nearly enough making things happen. Here's a shocking statistic I read recently: Read the full article »


text: The Gibson County Sheriff's Department says footprints in the snow leading away from a burglarized home in Patoka led to the home of one of two juvenile suspects in the break-in. Police followed the tracks to a nearby home in Patoka. A second juvenile from Princeton was taken into custody later in the day. The homeowners called police early Saturday morning after finding their back door wide open and a television unplugged. Police say items taken from the Patoka residence were found in the home of the Princeton juvenile. Both were taken to the Southwest Indiana Youth Village in Vincennes.


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Lebanon's government rejected a U.N. cease-fire plan backed by President Bush on Monday, demanding Israel immediately withdraw even before a peacekeeping force arrives and promising to send 15,000 troops to take control of the Hezbollah stronghold along the border.
Meanwhile, renewed clashes broke out early Tuesday between Hezbollah guerrillas and Israeli forces near the Lebanon-Israel border. Fifteen guerrillas were killed, along with one Israeli soldier, in fighting in the town of Bint Jbail, the army said.
Hezbollah's television station, Al-Manar, claimed the guerillas had inflicted casualties on Israeli forces near the city of Naqoura. It did not mention the fighting at Bint Jbail.
A Progressive Journal of News and Opinion Publisher, Zuade Kaufman Editor, Robert Scheer
© 2014 Truthdig, LLC. All rights reserved.


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More reviews by LLyouvegotmail
I have color treated hair and this is by far the best product I have ever tried. My hairdresser Imelda at Ambiance Salon in Springfield pa, used this on me once and I have forever since been addicted to it. It's not too expensive. The larger size is a great bargain, and it doesn't give me the greasy look. I have received ENDLESS compliments EVERY time I wear it,", from men, women and teens. TRY IT!
More reviews by goldrauschengel
In the beginning I received a trial size in the glossybox and I really liked this hair oil and bought a full 100 ml, I also gave smaller samples to my mother and sister to try... I liked the scent and my hair did feel softer after use (which is saying something because my hair is thick and dry and will always feel rather coarse), but it also had a bit of a darkening effect and I am not sure it´s really the best option for me...Right now I am testing some cheap drugstore serums and actually find them quite good...
More reviews by innerbeauty4eva
i have very knotty hair so after my shower i smear it and it makes brushing a lot easier and less hair falls out.yay!! plus IM OBSESSED LIGIT OBSESSED WITH THE SMELLL mmmmmm i wish they made a perfume with that aroma!!
I echo the other negative reviews on here, and also want to stress that this stuff is STRONGLY scented in a perfumey/incense kind of way that will trigger a migraine if you're prone to them!
Still on the fence. Just bought this and have only used it a couple of times. My hair generally responds well to oil (I will slather it in organic sesame oil and sleep in it). Putting a product in and leaving it after styled has me a bit on the fence.
It does make my hair light and airy (in a good way). The only down side for me is that I often like to curly my ends under a bit. And it seems to want to prevent my hair from wanting to hold a curl. I think maybe when I flat iron it, it will work a bit better. I'm not too sure. Or perhaps I'll trying applying it after I style.
I havn't given up on it yet. But I'm definitely not in love with this stuff right out of the gates.
My hair stylist was using this product on my hair and I absolutely loved how it smelled and the fact that it helped cut down on drying time. I went out and purchased it and used it for a few weeks. When I went back to my stylist she ran her hands through my hair and could not believe how much healthier it felt and asked what I had been using. I have very thick, wavy, color treated hair and while I find I still need some extra product this stuff helps tremendously and smells oh so yummy. I use it super sparingly as it is so pricey. Will purchase again if I can snag a coupon or will ask for it in my stocking ;) Should also mention that it is a huge plus not having alcohol in it which seems to be in so many similar products.
The argan oil thing is a gimmick. This is a silicone product with a little argan oil, and a hugely jacked up price. Do yourself a favor and buy yourself real argan oil.
17 out of 18 people found this review helpful. Did you? Yes No
I was using a moroccan argan oil from Pro Naturals that I ordered online from Beyas, but after reading so many positive reviews on MO I got myself a bottle. It made my hair really heavy and eventually greasy (only used a small amount), so I checked out the ingredients and suprise surprise SILICONES. Went back to pro naturals and my hair was soft and supple again, so no, MO is NOT all its made out to be.
3 out of 3 people found this review helpful. Did you? Yes No
I didn't expect a miracle from Moroccal Oil, and I didn't get one, but it's still a decent product. I apply a tiny amount, a glob about the size of my pinky nail, onto just the ends of my wet hair. I've been using it about twice a week for 3 months, and I think my ends are not as dry as before, but also not miraculously moisturized. I still need a heavy duty moisturizing conditoner, like the Joico KPak line.
With trial and error I developed a prejudice of considering hyped products as 'over-hyped'. So I did not think of buying this. My hair is thick and normal. And normally shampoo is enough. But because of heat styling and a bad highlight job I received a while ago, the ends of my hair turned straw-like and I got lots of broken and split ends. No conditioner or mask provided relief. So I bought this. In the first application Moroccanoil smoothed away all the roughness and sealed most of the split ends. I thought my hair would get oily quicker than usual but it did not make my hair oilier and the best is.Like most other cosmetics, you only benefit when you use it.


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Jurors get case in Jodi Arias murder trial
Alexander suffered nearly 30 knife wounds, was shot in the head, and had his throat slit. Arias' palm print was found in blood at the scene.
Arias said Alexander grew physically abusive in the months before she killed him, but there was no evidence or testimony during the trial to corroborate her allegations.
The defense has portrayed Alexander as a womanizer who used Arias for sex and abused her physically and emotionally. Prosecutors depicted Arias as an obsessed ex-girlfriend.
Arias' grandparents had reported a .25 caliber handgun stolen from their Northern California home about a week before Alexander's death - the same caliber used to shoot him. Arias was staying with them at the time, and the burglary occurred two days after the two exchanged text messages that indicated Alexander no longer wanted anything to do with her. Arias denies taking the gun, but prosecutors say she staged the burglary to get the murder weapon.
Martinez told jurors that Arias had been stalking Alexander and arrived armed and unannounced on the day she killed him, sneaking into his home at about 4 a.m. The two went to sleep together, then awoke and had sex.
At some point, Martinez said, Arias decided it was time to carry out her plan.
Nurmi told jurors on Friday that the state's theory is "nonsensical."
He pondered out loud: If Arias had planned the attack in advance, why not kill him right when she arrived at Alexander's home? Why leave a paper trail, starting with the police report from the burglary? Why rent a car instead of borrowing one from friends or family? Why use her debit card for gas and other purchases instead of cash?
"It doesn't make sense if you're on a covert mission," Nurmi said, adding Arias had numerous other opportunities to kill Alexander.
"But she didn't," he said.
Nurmi acknowledged his client is a liar. But he explained she isn't on trial for lying.
"Nowhere, nowhere in your jury instructions are you asked to convict Jodi Arias of lying," he said.
Arizona criminal defense lawyer Benjamin Taylor, who sat in on closing arguments, said the defense did a good job at raising reasonable doubt about premeditation.
"Nurmi showed she had plenty of time if she really wanted to kill him," Taylor said. "After today, it's going to be hard to get 12 jurors to agree unanimously on premeditation."
The judge previously instructed jurors that if they couldn't unanimously agree on premeditation but believed the killing was carried out with malice and not in self-defense, they could settle on a second-degree murder conviction.
Arias said she recalls Alexander attacking her in a fury on the day he died. She said she ran into his closet to retrieve a gun he kept on a shelf and fired in self-defense but has no memory of stabbing him.
Follow Brian Skoloff at https://twitter.com/bskoloff
The Associated Press


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Under The Sight Of Horus Lyrics - Varathron
Look in the sky the wingrd angels
Beyond the invisible horizon
The kingdom of isolted angels
Where stoneshaped shadows mourn (what they're lost!)
The mystic vision of Osiris
The mighty god of Sevia
Till, the promising truth of horus
(As) predicted by priest mefantha
You laugh for darkness domination
You laugh for living plagues
The owner of curse once covered the city
Transform the demon inside you.
Under the sight of horus
The chosen one
The lord of sacred pain
The king of desolation
Hail erebus, lord of death.
Beyond the southern seas
Where mortal search your path
A gate to underworld
The vision of thousand priests
Under the sight of horus
The stone valley of death
There, you will find the truth
From the sacred book of invocation
(And then) you will open the gates for them.
Click here to submit the Corrections of Under The Sight Of Horus Lyrics
Please Click Here to Print Under The Sight Of Horus Lyrics
The following area is only for review, if you want to submit the lyrics or the corrections of the lyrics, please click the link at the end of Under The Sight Of Horus Lyrics.


text:
The Fort Myers Police Department is looking for the following people:
- Jacques Leaphart (d.o.b. 9-9-75) Retail Theft
- Tracey Brock (d.o.b. 5-4-65) Sale of Cocaine
- Michael Savage (d.o.b. 1-12-82) Grand Theft
- Justin Hall (d.o.b. 10-13-81) Grand Theft Auto
- Terry Williams (d.o.b. 12-4-67) Sale and Possession of Cocaine
- Wendell Dawson (d.o.b. 2-27-87) Sale and Possession of Cocaine
Releasing most wanted lists allows the community to actively participate in making their neighborhoods safer places to live. Chief Doug Baker says, "The Police Department is only as successful as the community allows us to be. We need more citizens to help us put criminals in jail and report suspicious activity." Chief Baker has put many programs in place to encourage citizen participation: Operation Safe Neighborhood focuses on removing guns from City streets. A task force assigned to the unit is enhanced by intelligence gathered from citizens and informants. Also, the Illegal Gun Bounty Program, with the assistance of Crime Stoppers, provides an anonymous tip line and offers cash to anyone who provides information of a person illegally in possession of a firearm.
If you have information about these individuals or any other crime, please call FMPD at 321-7700, Crime Stoppers at 1-800-780-TIPS or text a tip to C-R-I-M-E-S (274637) Keyword: FMPD. You can remain anonymous. You can always find an updated list of the City's most wanted at www.fmpolice.com.


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Watch Ed Sheeran Perform Epic 'Runaway'/Backstreet Boys Mashup [VIDEO]
Here's a simple math equation for you: Ed Sheeran + Backstreet Boys = LOVE.
The best-selling boy band in history, the Backstreet Boys became superstars in the '90s and are still going strong. Formed in Orlando, Fla., in 1993, BSB consists of A.J. McLean, Howie Dorough, Nick Carter, Kevin Richardson and Brian Littrell. Their self-titled debut U.S. album was released in 1997 and peaked at No. 4 on the Billboard 200. Hits including 'Quit Playing Games (With My Heart)' and 'As Long as You Love Me' led to the album's eventually being certified an amazing 14-times platinum. Their next full-length release, 1999's 'Millennium,' featuring the worldwide smash single 'I Want It That Way,' nearly equaled the feat, at 13-times platinum. Richardson left the group in 2006, while the group went on to record two albums without him. He returned to the fold in 2012, in time to celebrate BSB's 20th anniversary.
Here's a simple math equation for you: Ed Sheeran + Backstreet Boys = LOVE.
The Backstreet Boys have canceled their upcoming concerts in Israel due to the "security situation" in the country, they announced on their website yesterday (June 20).
As a special treat for fans, Michael Buble has been doing song requests on Instagram for his pre-show warmups during his world tour. Some of the more recent examples include covers of *NSYNC, Backstreet Boys, Kanye West and Jason Mraz.
Thanks in part to the recent trend of boy band revivals, 2014 is starting to feel like 1997 all over again, rivalries and feuds included. Verbal shots were fired between 'N SYNC's Joey Fatone and the Backstreet Boys' Nick Carter, but at least one member of this conflict is ready to forgive and forget for old times' sake.
Get ready to shriek, NKOTBSB fans -- we have some unbelievable news for you! Nick Carter and Jordan Knight have just announced that they will be releasing an album together and embarking on a fall tour. Say whaaaat!
With the recent resurgence of boy bands both new and old, we've decided to look back at our favorite boy bands of the '90s, the decade where those sweet, sweet harmonies (and even sweeter dance moves) all really started.
It may be 2014 but the '90s rivalry of Backstreet Boys vs. *NSYNC has been briefly resurrected through a war of words started by *NSYNC alum Joey Fatone. Yesterday, Backstreet Boys' Nick Carter took to Twitter to respond to Fatone's comments.
Joey Fatone's new title is "Crusher and Destroyer of Dreams." The former member of 'N Sync took all of a minute to crush the hopes and dreams of 'N Sync fans the world over and to throw a little shade at Backstreet Boys' doorstep.
Aaron Carter, the former bone of contention between Hilary Duff and Lindsay Lohan, missed his big brother Nick's wedding to longtime girlfriend Lauren Kitt this weekend. WTF?
The last bachelor of the Backstreet Boys has finally tied the knot. PEOPLE reports that Nick Carter married Lauren Kitt at a ceremony in California.


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2005 Subaru Legacy 2.5i AWD 4dr Wagon (2.5L 4cyl 5M)
First Subaru and boy I am impressed. In 1.5 years of ownership I have had zero problems. In combination driving average about 28 mpg. On a trip depending on how fast we drive we can get around 32 mpg. The car can be a little cramped on a log trip especially if you have more than one passenger. Rear seat room is tight. I am 6-1" and wish that there was a little more leg room for the driver. In summary, great car.
the full review
Last year I purchased the 2005 Subaru Legacy 2.5i wagon. I have been very impressed with the overall fit and finish of this vehicle. Its safety features were excellent and numerous. Its projected resale value was excellent. This vehicle has met and exceeded all of my expectations. I will be a Subaru owner for life.
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This is Subaru #6 for us. Seems great so far, lots of features, quiet and smooth. Best mileage of the six, avgeraging over 30 mpg in the first 3,000 miles. It doesn't feel quite as fast as our '01 GT was. Nice alloy wheels. Storage is good. Love the black metal flake paint. Headlights are awesome, providing great lighting. Also enjoy the trip computer, outside temperature and two resetable odometers. And the fact that you can't lock the keys in the ignition anymore. Most outstanding is the value for the dollar. There is nothing that comes close for less than $20K. One friend said "that looks like a seriously expensive car!" Probably less than half the cost of her SUV!
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Flaxseed For Hiv
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
FlaxseedHello, recently I was told by a fellow gym-goer that flaxseed is a great supplement to take for a variety of reasons. The reason that peaked my interest was that it can help remedy joint (shoulder in my case) problems. I have some lipodystrophy and...
Response from Keith Henry, M.D.
University of Minnesota, School of MedicineFlaxseed may be helpful in lowering some lipid levels. I have not seen much published on its use in HIV-related lipid elevations in regards to efficacy and safety. I am not aware of a good study demonstrating a benefit with safey for joint or... Read more »
benefit of flaxseedCan you safely take flaxseed with the medication you take for AIDS?Thanks, Anne... Read more »
omega-3 fish oil and flaxseed with diet and medsI have borderline high cholesterol, my good HDL is 47, and LDL 125,TRIGLYCERIDE 171 , and i take... Read more »
Exercise: The Best Therapy for Managing Side EffectsThere are many benefits of exercise in HIV disease. Besides the evident improved self-image, energy level, and mental outlook, several research studies performed with HIV-positive people have found the following clinical benefits in body composition... Read more »
Just the Flax, PleaseJust leave it to me to overwhelm you with information on yet another dietary supplement that might have benefits for people living with HIV. But wouldn't it be great if there were a legitimate supplement that has been shown to decrease your risk for... Read more »
Fighting the Fire: HIV and Chronic InflammationYour immune system on overdrive, and that can wear down vital body systems over time. -- Nelson Vergel, 55 HIV treatment activist Diagnosed with AIDS in 1986 Nelson Vergel (Illustration: A.E. Kieren) Both HIV and aging can cause... Read more »
Why Nutrition Matters in HIV Patient CareNutrition has been referred to as one of the great "black boxes" that remain in HIV patient management. Long overshadowed by dramatic advances in antiretroviral therapy and more medicine-oriented approaches to disease management, we frequently... Read more »
Connect With Others
Macular Rash inside mouth? Please respond.
Posted by Anonymous, 3 RepliesI recently had one red spot on the hard palate of my mouth and one on my shoulder that only last a day or two. Could this be a sign of macular rash associated with HIV acute reaction? I am concerned since I came across pictures of rash's on the web... Read more »
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PLYMOUTH — Michelle Bougher wants area residents wishing to get into shape to come to attention.
Bougher is offering a fitness "boot camp" in a very unique setting. The four week program is for those who are willing to jump in boots first.
"It's a little different than just going to the gym," said Bougher of the program. "This is for people who want to make a little more commitment to the program. It's not just the workouts but also nutrition and a full healthy lifestyle."
The setting isn't just going to the gym either. The sessions — held three times a week — are set at Centennial Park in Plymouth.
"We get together right there by the big wooden playground (on the park's west side near Michigan Street)," said Bougher. "We have all the equipment we need right there. If the weather gets bad as we head into winter we will move the sessions to Plymouth Family Tae Kwon Do (in downtown Plymouth.)"
The time requires some commitment as well. Sessions begin at 5:45 a.m.
"That lets anybody who has to get the kids to school or get off to work have a chance to get a great work out in right away," said Bougher. "Then they have plenty of time to get everybody off to school and have the whole day to look forward to."
There will also be evening sessions beginning at 6 p.m. for those who can't make the early morning.
Bougher is certified in group fitness as well as having an Aerobics and Fitness Association of America certification in personal training and has seen great results with the program.
"Lots of people want to have magical results – work out once a week, eat whatever they want and still get fit," said Bougher. "People committed to this program – the nutritional information and the lifestyle – have seen really great results."
For more information or to sign up you can visit http://www.plymouthfitbootcamp.com/


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Washington, DCThe Endocrine Society is pleased to announce the recipients of the 2014 Early Investigators Awards and the Future Leaders Advancing Research in Endocrinology (FLARE) Internship Awards.
The Early Investigators Awards, supported by the Endocrine Society, were established to recognize the achievements of early career investigators in endocrine research. The FLARE Program, which launched in August 2012, provides training and professional development opportunities for underrepresented minority senior graduate students, postdoctoral and clinical research fellows in hormone health research. The FLARE Awards are supported by the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
This year's Early Investigators and FLARE Awards will be presented at the joint meeting of the International Society of Endocrinology and the Endocrine Society ICE/ENDO 2014 in Chicago, IL on June 21-24.
The 2014 winners of the Endocrine Society's 2014 Early Investigators Awards for Accomplishments in Endocrine Research are listed below.
Additional information on this award and award recipients is located on the Society's Awards and Grants site at http://www.endocrine.org/awards/student-and-early-career-awards/early-investigators-awards.
The Endocrine Society's 2014 FLARE Internship Award winners are listed below. FLARE Interns will serve as leaders on Society-based governance committees for one year and as mentors to undergraduate students in the Minority Access Program, which is designed to encourage underrepresented minority undergraduate students to pursue advanced degrees in the biomedical sciences.
FLARE is supported by the NIDDK under Award Number R25DK096937. Details about this award and recipients are available on the Society's Awards and Grants site at http://www.endocrine.org/FLARE.
Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 17,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Washington, DC. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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School of Nursing
The School of Nursing is seeking qualified candidates for the following;
Assistant/Associate Professor
The School of Nursing of Auburn University in Auburn, Alabama invites applications for a full-time, 12 month, tenure- track position to begin August 16, 2014. Candidates with expertise in an area of Adult Health, Mental Health, Pediatrics, Maternal/Infant or Community Health are sought to teach our highly qualified student body. Responsibilities include: Classroom and clinical teaching, scholarly productivity in a supportive environment for clinical research and participation in college and university committees. Minimum qualifications: Master's degree in nursing with a specialty in an area of Adult Health, Mental Health, Pediatrics, Maternal/Infant or Community Health, and significant progress toward completion of doctorate. Doctorate in nursing or related field is required for tenure. Must have current clinical and teaching experience along with current clinical skills. Desired qualifications: Earned doctorate in nursing or related field, baccalaureate, graduate and on-line teaching experience in nursing and evidence of scholarly productivity. Record of funded research.
All applicants must be eligible for an Alabama RN license, meet eligibility requirements to work in the U.S. at the time the appointment is scheduled to begin and continue working legally for the proposed term of employment; must be able to communicate effectively.
Rank and salary commensurate with education and experience.
Submit letter of application, vita, official undergraduate and graduate transcripts, three letters of reference and any other optional supporting materials on-line via the link listed below. Review of applications will begin April 20, 2014 and will continue until the position is filled.
All applicants should be submitted through the online application:
For more information, please visit our website at:
Auburn University is an Affirmative Action/Equal Opportunity Employer.
Minorities and women are encouraged to apply.
Count Your Blessings at Thanksgiving
5 Ways to Handle the Holidays When Your Life's in Chaos
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Lung Cancer Awareness
Movember: New Face of Men's Health
Соруright 2014Minority Nurse is Registered in the U.S. Patent and Trademark OfficeSpringer Publishing Company, LLC


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As federal policy makers push for GHG regulation and transparent markets, the California experience shows what works and what doesn't work.
Greening Connecticut
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Daniel P. Venora is a partner in the law firm Wiggin and Dana in New Haven, Ct., where he specializes in energy and utilities.
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In the event you're an enthusiastic gamer that prefers to get a brand new television, you are in somewhat of a situation that is difficult. Television manufacturers in Sydney move to great pains to offer their displays' film- and television-viewing possibility, but do not actually talk about how gaming computer or PS4 blocked in or how they execute with an x-box One.
You produces big screen gambling, and can discover a video that highlights your games console, , however an activity that is enjoyable; it is also not entirely impossible be trapped using an inferior encounter and to choose a poor one. Here are three essential factors you will must tackle when you are choosing an excellent television for computer or games console gambling.
1. Is there a-game Style?
This feature's title has become the sole fair point that television producers have resolved on in the past couple of years. Television sets' sport ways, more often than not, flip off image-processing that is just as much as potential — movement blur decrease and color managing devices and all the border honing which make your bluray pictures seem not bad. These attributes working in the movie processing pipe each of your television set introduce their particular small delay prior to the screen is really hit by the image.
A Game style that is good will turn off all of this frivolity and produce a photo that's as near as you possibly can to what games console or your computer is delivering. This might seem just like an awful point — and image-processing chicanery is very good for pictures, of program — but you're going to have to to stop some eyecandy, in case your aim is a screen that is reactive. Significant: if your games console or computer working by means of a radio, this will do a unique image-processing, improving feedback insulate, should youn't eliminate it.
The most interesting are 32 inch TV deals at WB20TV
2. Are there Input Lag?
That is one thing that is not always signified in specs on the web site of a television manufacturer. Enter lag is the complete bane of gambling — it is the gut- delay between typing an activity and it being reproduced onscreen. A great deal of feedback lag signifies that when you are enjoying with a fast game, or one which needs input signal that is subtle, you are in a drawback.
Therefore, your objective would be to find a television set using the best input lag that is possible. Your selection should be restricted by that largely to LCDs, which have more rapid processing than plasma screens between screen and input signal, even though you can find several plasma screens that execute quite pretty much. You're going to have to depend on on third party assessments since feedback insulate is not an amount that manufacturing companies assess in specs. The feedback lag database of HDTVTest UK is priceless — simply locate the foreign product that matches with the British record, you can buy 60 smart TV at WB20TV.
3. Is there A Natural Refresh price that is Quick?
This is not a problem since their subfield refresh prices are in the in the region of Hertz and above. In the event you're choosing a liquid crystal display, you are going to need a 100Hz or 200Hz refresh rate cell that is native — it is the one thing that matters. Just about all television manufacturers have software body interpolation capabilities — Sony's is MotionFlow, Samsung's is obvious movement — However, these waste running period duplicating and doubling structures that are personal, raising feedback insulate.
Whether there's an enormous distinction between a 50Hz indigenous screen as well as a 100Hz indigenous screen is a subject of some disagreement — with television sets, that natural refresh price is not as easy as you'd believe, with all input signals over HDMI arriving at 50Hz in the very first location (also your over-powered gambling computer is secured to 50fps). Image-quality does enhance without affecting reaction time, that will be its primary advantage over an applications framerate enhancer.
A fast notice On Plasma Screen Versus LED-LCD
Lcd TVs have black levels and much better contrast compared to greater part of LCD TVs, so when you are really viewing television or playing with games both of these measurements are enormously more significant than the indigenous quality or the quality of your screen of the game. In most cases, though, lcd shows do have more more built-in feedback lag than LCDs, making them less sensitive for twitch gambling. I am able to recall the-hell of trying to play with Guitar Hero -inch Pioneer plasma screen — it is maybe not worth the heart-ache.
Therefore, while I am careless to imply anybody purchase liquid crystal display over a plasma screen that is lovely, in the event that you're going to be performing lots of gambling, and while plasma do not appear as great they are the selection that is more intelligent.
What Are a few Great gambling TVs at this time?
With these three significant points in your brain, move out and find your-self a television that is new. In case you need some propositions, I could anecdotally attest to the gambling operation of the 2013 W700A and especially the W800A set of Sony. Plasma TVs and Samsung.com's Series 8, if they can be found by you on a clearout selling someplace, are just partially worse when it comes to reactivity and input lag, but provide a pleasant increase to comparison. I will be examining loads of 2014 TVs soon, so stay tuned and check at wb20tv.…


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Senior Member
i sacrifice a teemo to the great gank queen evelynn... o dark goddess, please summon forth a mighty red!
i guess i didn't sacrifice enough teemos ;_;
bump for reds
last bump for the night
I've been playing for a year and a half, never understood how the attack speed % worked until now.
Systems Designer
Sure, I can forward this along to people working on HUD stuff. Summon the power of Brackhar to look at it.
There could be some concern with the amount of clutter that goes on in the stats window - that's my primary concern - but if the hover tooltip is also wrong that's kind of a downer.
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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For horse lovers this is a great series about life and living with horses.
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Songs for Idols: Just don't let Sanjaya sing any of them
Here's some guy's list of songs that should be sung on American Idol. The suggested artists are Journey, the Pretenders (other than "I'll Stand By You," which Gina sang so very well last night), Boston, Poison, Heart, and Ted Leo and the Pharmacists. Ted Leo? Really? Oh, I guess that was a joke.
As for the rest, well, Heart has already made at least two appearances — both Carrie Underwood and Gina Glocksen gave "Alone" a good effort. But somebody should try "Dog and Butterfly" or "Straight On." And if Gina really wants to be a rocker, she should go for "Barracuda."
But I agree with the other ideas, especially the Pretenders — though I remember Alaina Alexander butchering "Brass in Pocket" during early rounds this season. Here are some more I'd like to hear:
(Click "read more" for a list of groovy tunes.)
1. Anything by Garbage. But I'm sure Shirley Manson would rather not see her songs turned into rubbish.
2. "Cruel to Be Kind" by Nick Lowe. Because it rocks.
3. "Not a Virgin" by Poe. Yeah, that would never fly. But wouldn't it be fun?
4. Anything by Bill Withers — but who's up to the task? Phil Stacey, maybe.
5. "Any Place I Hang My Hat Is Home" by Barbra Streisand. Wait. That might be sacrilege. But Melinda, give it a try anyway, OK?
6. Anything by the Carpenters. I mean, come on.
7. "Where Do I Begin?" by Shirley Bassey. I'm looking at you again, Melinda.


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The name of a cool ninja dude from CAPCOM's Street Fighter and Final Fight. He's a master of the Bushin style of martial arts.
Bushinjuu Power!
The term for a male person who is not a boy anymore but not yet a man. Can be used to describe junior-highers.
Tina: Yeah, so there's that guy I told you about...
Sara: OMG, that's the guy??!
Sara: OMG, that's the guy??!
作者 Annonymous Person Number 1000 2008年12月31日
A ninja that is the master of "Bushin".
作者 Samurai Katsu 2003年9月03日
In the language of the dark side, a "guy" is anybody or any group at the depot. Usually used as the first word in a sentence and often used consecutively in a sentence to give it a more pronounced effect. sloth, dum dum and handy are examples of the guy.
"Guy, GUY, GUYYYY! Go tell the guy that the guy who sands yesterday left the guy on the liff with too much travail todays!"
作者 The Conehead 2005年1月24日
Best Street Fighter character after Ryu. He is a ninja that lives in the present and has mastered the Bushin style. He originates from the legendary Beat-em'up game "Final Fight".
He's coming to Capcom Fighting Jam :p
作者 Seta_Soujiro 2004年9月04日


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I've had very few moments, while photographing, that could take my breath away…this is one of them. "Now that you have purified yourselves by obeying the truth so that you have sincere love for each other, love one another deeply, from the heart." ~ 1 Peter 1:22 { Houmas House Plantation Wedding | Plantation Wedding Photographer | […]
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|List A - Z | Top 1000 | Random | Origins
VedaRate Veda: Do you like this name?
Get creative with Veda | Add to list (0)
Veda meaning and name origin
Veda \v(e)-da\ as a girl's name is of Sanskrit origin, and the meaning of Veda is "knowledge, wisdom". The Vedas are the four sacred books of the Hindus.
Veda has 5 variant forms: Vedis, Veeda, Veida, Veta and Vida.
For more information, see also the related name Laveda.
Veda is also pronounced similarly to Vieda. Other suggested similar baby names are Beda, Heda, Leda, Meda, Neda, Reda, Veeta, Vega, Velda, Vena, Vera, Verda and Vita.
View a list of the 3 names that reference Veda.
Popularity of Veda
Veda is a very popular first name for females (#1138 out of 4276) but an uncommon surname or last name for all people (2000 U.S. Census).
Displayed below is the baby names popularity of Veda name for girls (2012 statistics). Compare Veda with its variant forms and related girl baby names.
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Best & Worst Dressed - 'The Company You Keep' Premiere
The company on the red carpet certainly kept things stylish for 'The Company You Keep' premiere — if only in black and blue.
Ireland Baldwin
Aspiring modelIreland Baldwin showed off her model-esque stature in leg-legthening skinnies and a tailored blazer. Sand-colored peep-toes and a printed scarf finished things off.
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