text:
does not include shipping and tax
|The most helpful favorable review
|The most helpful critical review
1 of 1 people found the following review helpful:
By Christopher from USA on 2012-12-07 21:15:19Things I liked:This gun is a hard hitter that makes small game (my experience) think twice
Things I would have changed:metal, metal, metal
What others should know:the right pellet makes all the difference
0 of 0 people found the following review helpful:
By Bret from USA on 2012-11-30 00:40:53Things I liked:Deadly accurate when it fires. Feels good for an adult. I hope that someone comes up with a wooden stock for it. If they get the pellet magazine problem fixed it might be more fun to shoot.
Things I would have changed:The first shot I fired never came out of the barrel. It jammed in the clip. It took me half an hour with a cleaning rod to maneuver the mangled pellet so that I could get the magazine out. This happened repeatedly with several kinds of pellets. It happened with both of the stick magazines. There is a serious problem here. Sometimes the magazine jams and will not come out. I am a fairly experienced air gunner and was following all the instructions carefully.
What others should know:Beware! This is not the gun to carry if you are expecting the zombies to arrive. It has a tough time firing the pellets out of the magazine. The magazine stick or fall out.
|By Ed from USA on 2014-11-28
|By Josh from USA on 2014-03-26

subset: commoncrawl


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The Perfect Puppy
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how to raise a well-behaved dog
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Great Book! I like the training style and such.
This is a very good book, but it is speceficly for training puppies, not dogs, so it is kinda basic training. I would also recommend Gwen Bailey's "Training Your Superdog" because that has more advanced training. Good photos in this book.
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November 24, 2014
Authorities have identified the three people killed in a snowy two-vehicle accident in northwest Nebraska on Friday.
Dawes County Attorney Vance Haug says all three were in an pickup that slid out of control on U.S. Highway 20 about four miles east of Crawford. The truck was hit by an oncoming semi.
Haug says 66-year-old Patsy Baumgarner of Lincoln, 43-year-old Sandra Clark of Phillipsburg, Kansas and 23-year-old Brandon Clark of Lincoln all died. Baumgarner was Brandon's aunt and Sandra's mother. The driver of the semi suffered only minor injuries.
Haug says the snowy conditions contributed to the crash.
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Welcome to Healthy USM, the University's employee wellness program. Our Program offers USM employees, dependents, domestic partners, and retirees, health education programs and services.
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Learn more about this disease that affects nearly 24 million Americans.
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The weather outside may be unsightly, but your skin doesn't have to be. Learn how to banish dry skin and give your winter skin care regimen a boost.
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In a world full of stress, a kind act could uplift one's spirits and put a smile on their face.
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Sarah Ferguson is to appear on Oprah Winfrey's chat show in order to talk about her recent scandal.
The 50-year-old is set to explain the alleged revelations that she offered access to her ex-husband Prince Andrew in exchange for money.
Expected to be taped on Friday, the interview will be broadcast next Tuesday.
The Duchess has been putting on a brave face since the news broke, joking about the incident at a recent book fair in the US.
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HOME MLB Boston Red Sox Gear Boston Red Sox Mens Boston Red Sox Mens Jerseys Boston Red Sox Mens Jerseys Baseball over $60 (29 items) Product ID: 284769
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Sacramento Kings vs. Golden State Warriors
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Northern California's two NBA teams face off as the Golden State Warriors host the Sacramento Kings. The Warriors have gained the upper hand in this rivalry, posting one of the NBA's best records this season. Point guard Stephen Curry has earned a reputation as a rising star in the league, known for his smart passing and deadly outside shooting. He's joined by veteran big man David Lee, a great rebounder and prolific scorer, and several exciting young players. The Kings have some talented youngsters of their own, including unpredictable center DeMarcus Cousins and former Rookie of the Year Tyreke Evans.
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Bring your own snacks. Otherwise it's $15 for a thing of cotton candy or $12 for a nachos.Disney On Ice: Worlds of Fantasy dining • Oct 13 2014 star this tip starred
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How they know this number exactly I don't know, but according to industry analyst Informa Telecoms & Media, worldwide mobile penetration will hit 50% (3.3 billion subscribers) today.
Not tomorrow. Not yesterday. Today.
Amazing that they know this. Funny thing is I was just telling my partner Gary, that the Mayan's predicted the end of the world on December 21st, 2012. I'm not sure how they know this one either.
Whether they are right or wrong is not really what's important (Informa Telecoms… not the Mayans). What's important to note is what an gigantous number that is. 3.3 billion mobile subscribers.
Via Telecoms.com:
"The mobile industry has constantly outperformed even the most optimistic forecasts for subscriber growth," said Mark Newman, chief research officer at Informa Telecoms & Media. "For children growing up today the issue is not whether they will get a mobile phone, it's a question of when.
"It is difficult to imagine how a modern economy could function without mobile telephony and a number of recent studies have shown that the mobile phone is having a hugely positive impact on the economies of emerging markets."
The first cellular network was launched 26 years ago. I still remember my first Radio Shack mobile phone that I used during the 1989 New York City Phone Company Strike. I think I paid $1.50 per minute, and it looked like a World War One field phone.
Informa estimates that mobile networks cover 90% of the global population, and that there are networks in 224 countries.
As of the end of September, 59 countries have mobile penetration of over 100%, with 27 countries having less than 10%.
These are staggering numbers. The reach of the mobile phone continues to grow at an amazing rate.


text:
Broken Arrow Library is closed Oct. 27-Dec. 7 for library improvements. Holds may be picked up at Martin Regional Library.
|Post date
|Storytime with Tulsa Shock Players
|Tue, 07/22/2014 - 10:46am
|Books to Treasure Author/Illustrator to Share His Talents with Families
|Mon, 07/14/2014 - 4:08pm
|Touch-A-Truck Event to Super Size Martin Regional Library
|Fri, 07/11/2014 - 2:54pm
|"Chapters" Literacy Fundraiser to Feature Authors David Berg, John Searles and Laurence J. Yadon
|Thu, 07/10/2014 - 11:24am
|Enjoy an Evening with Author Wendy Corsi Staub
|Wed, 07/09/2014 - 3:52pm
|Annual Jeanne B. Goodwin Storytelling Festival Features Kirk Waller
|Thu, 06/19/2014 - 4:09pm
|Tulsa City-County Library Features Adult Summer Reading Program and One Book, One Tulsa
|Mon, 06/16/2014 - 2:34pm
|Novel Talk: I AM HUMAN: Individual Empowerment from 1920 to Today, Featuring Author Laura Moriarty
|Thu, 06/12/2014 - 9:34am
|"Speakeasy" Fundraiser to Benefit Central Library's Renovation
|Thu, 06/12/2014 - 9:30am
|Digital Festival Rolls to Librarium Featuring Latest eServices
|Thu, 06/05/2014 - 2:22pm
|Tulsa's Channel 8 Reads @ the Library Features Familiar Faces
|Tue, 06/03/2014 - 10:51am
|Join The Friends of the Tulsa City-County Libraries to Promote Literacy and Win Prizes
|Tue, 06/03/2014 - 10:46am
|Celebrate Family History Month in July with the Genealogy Center
|Fri, 05/30/2014 - 9:56am
|Storytime in the Park Begins with Special Debut
|Tue, 05/27/2014 - 2:18pm
|Summer Reading Program Perfect for Children and Teens
|Tue, 05/27/2014 - 2:13pm
|Asian-American Festival to take place June 7
|Tue, 05/20/2014 - 9:54am
|"Tulsa Central Library Renewed" Launches $1 Million Public Fundraising Campaign
|Mon, 05/19/2014 - 3:51pm
|Library Presents Young People's Creative Writing Contest
|Mon, 05/05/2014 - 9:52am
|Ann Patchett to Receive 2014 Peggy V. Helmerich Distinguished Author Award
|Tue, 04/29/2014 - 1:17pm
|"The Bully Plays" Presented by Sun Caste Reader's Theater Group
|Mon, 04/28/2014 - 3:12pm


text:
|15 May 2009
Mouse single click too sensitive...
Has anyone else had the problem of single clicking an object to focus on it but having it execute instead?
Example: I select a music (MP3) to Edit - rather than focus on the MP3 Explorer launchs the file and begins to play.
Possible (though illogical solution) - the speed of the mouse being set to higher movement seems to stop the behavior. ie: slower movement rates of the mouse present the problem.
Just wanted to know if anyone else has seen this behavior.
|My System Specs
|15 May 2009
Hello Rkseagle,
When using single-click, you would just want to let the mouse pointer hover over the file to select it instead of clicking on it. If you are using a touchpad instead of a mouse, then you may need to adjust the tap sensitivity to help prevent tapping when you are just moving.
Hope this helps,
|My System Specs
|15 May 2009
Thanks for the response Shawn.
The problem is that no matter the 'hover' time - the file opens with a click rather than a double click.
I looked into increasing the hover time, no help.
I've set file and folder options to look for double clicks, no help.
There seems to be a sensitivity in there somewhere that takes away my control of the mouse selection process and only by increasing the mouse movement have I been able to find any relief at all.
Probably gonna chuck this Dell mouse for something a little fancier to see if that helps.
Thanks again.
|My System Specs
|15 May 2009
Do you have a setting like this one in the Mouse setting in the Control Panel that you may be able to adjust for this?
|My System Specs
|15 May 2009
Yes, and using it tones down the problem a little bit.
Oddly, increasing the speed seems to work best. The slower settings make the problem almost unbearable as I cannot even select any file in Explorer without it taking off.
|My System Specs
|15 May 2009
Interesting. You would think that it would be the opposite of that.
|My System Specs
|18 May 2009
No, actually, it makes perfect sense. if you set it for slower the time interval between clicks is allowed to be longer, thereby making your problem worse. Obviously your mouse is sending click indications even when it is not clicking. Therefore, setting it to a faster setting lowers the time interval allowed between detected double clicks, thereby making your problem more manageable.
However, the larger problem seems to be your mouse itself - I'd check to see if you need to replace it (if it is a corded mouse) or else check for updated drivers / hardware problems if it is a cordless mouse. battery check might be a good idea as well.
FWIW, it would have helped to know these things ahead of time as well....
|My System Specs
|18 May 2009
Yes, Thanks John...
I've only had one other mouse go bad on me and this took some time to figure out.
I had come to the same conclusion and as time and money permits I'll likely move up to a better mouse...
|My System Specs
|18 May 2009
What mouse do you have, and what is it's age?
I'd find a nice old used PS2 mouse to replace it with in the interim as this will drive you more and more crazy.
Trust me, I have had this happen to me - that is how I know that this was happening - and it took me almost a week before I finally suspected the mouse.
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Steal away to cool temperatures, stunning views, great wine, and the peace that comes from solitude. Make Virginia your autumn playground.
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Windmill Point House
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Who's Who : the essential directory of the noteworthy and influential in all walks of life, in the UK and worldwide, published annually since 1849.
Do you know your Royals? Learn more about them on the Royal Family page.
Plus Who Was Who : over 100,000 entries from the archives of Who's Who dating back to 1897: the definitive roll-call of the last 100 years of British history.
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Use the feature article archive to explore pages on topical events, with famous Who's Who figures highlighted throughout.
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Today in Who's Who
World War One remembrance
On 11 November 1914 few could have imagined that the war would continue for another four years. Who Was Who highlights the lives of politicians, soldiers, leaders and more in this latest feature article, as we remember World War One 100 years on.
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Who's Who includes autobiographical information on over 33,000 influential people from all walks of life. The 166th edition includes a foreword by Sir Francis Richards reflecting on the 'changing face of British society' since the First World War.
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These stars embraced slimmer silhouettes for new roles, onscreen and off
Credit: Sal Bautista /Stargaze; Chris Weeks/WireImage
Updated: Thursday Dec 29, 2005 | 12:00 PM EST
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"She did it on her own – no trainer," a pal says of the Less Than Perfect star (left, in 2004; right, in December), who lost about 30 lbs. One trick? Working out to foreign-language tapes, Rue told Extra.
Copyright © 2014 Time Inc. All rights reserved. Reproduction in whole or in part without permission is prohibited.


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Satya: A Prayer for the Enemy
USA, 1993 (MIFF 1995, Documentary)
Director: Ellen Bruno
Since the Chinese occupied independent Tibet in 1950, more than one million people have been tortured, executed or starved to death for their role in the demonstrations against Chinese occupation.
Tibetan Buddhist nuns have taken the lead in this resistance by fearlessly staging courageous demonstrations for independence and have been brutally treated by Chinese authorities for their role in criticising the Chinese state.
Satya is a gentle film which slowly delivers personal testimonies of these Tibetan nuns. It provides an inspiring inside view into their non-violent actions in a style which oozes with feminine strength.


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text: Week 3: Rumba in a soft and romantic look"I wanted my gown to be soft and romantic. I channeled the iconic, Rita Hayworth, when designing it,? Smirnoff told InStyle.com. As for partner Jacoby Jones, he had a shirt, but then... ?we talked about it and decided that this was the moment to go shirtless!?Read MoreLess


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Find records of Frances Warner
Find birth, death, marriage, military, and other records of Frances E Warner at Ancestry.com.Search for records
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Frances E Warner (1907 - 1993) was born on April 24, 1907. She was born into the Warner family.
There are no known spouses or children on file for Frances. Frances died on February 10, 1993 at 85 years of age.
Frances E Warner's last known residence is at Oklahoma City, Oklahoma County, Oklahoma.
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Dozens Get Sick After Catching Mysterious Illness While Visiting Disney World
Walt Disney World bills itself as "the happiest place on earth," but it was anything but for several dozen people who became ill after visiting a nature tour in June.
Walt Disney World bills itself as "the happiest place on earth," but it was anything but for several dozen people who became ill after visiting a nature tour in June.
In just one more example of the way Christianity is getting kicked out of public and private life, USA Today reports a small hotel in England has taken the Gideon Bibles out of all its rooms, and you won't believe what has replaced them.
There's something inherently cool about a small town. The people are nice (although they all know each other and can be in everyone's business), there's no traffic, and the stress level can be lower. I'm headed to my one-stoplight hometown in Nebraska for a little family bonding time next week and we're planning to sit on the deck and stare at the trees, and ask the local farmers for permission to walk into their fields and pick corn. Why vacation in a tropical location when you can have that kind of fun? Small towns rock.
Rand McNally and USA Today named the best small towns in all of America this week. Did Lufkin and Nacogdoches make the list?
X-ray scanners have caught air travelers with all sorts of strange and embarrassing things in their carry-on luggage. But it would be hard to top the images captured last week at the Shar-Jah Airport in the United Arab Emirates when an Egyptian couple stuffed their five-month-old in a suitcase and tried to sneak him past security.
If you think airport security screenings are already too invasive, you probably won't like this.
Within the next couple of years, the Department of Homeland Security will begin using laser-based molecular scanners at airports and border crossings. And what they reveal could surprise you.
You expect hotels and the nicer "brand name" roadside motels to be clean and healthy places to stay, but don't bet on it. Researchers at the University of Houston School of Hotel and Restaurant Management say hotel rooms are nowhere as clean as they look, and they can even make you sick.


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| Denver, United States Of America
15 June 2014 -18 June 2014
Educational & Professional Training Institutes
National ADA Symposium will provide a professional development opportunity for all interested professionals. The conference will be held every year to make it an ideal platform for people to share views and experiences in technical assistance, information, and training on the Americans with Disabilities Act and related disability laws. The venue of the annual symposium is Hyatt Regency San Antonio. A wide spectrum of professionals engaged in Americans with disabilities act education, experienced as well as newcomers, will attend the conference. It invites distinguished researchers from all parts of the world to discuss exciting current developments and to debate on the future research trends in our field. Come to join this annual symposium.
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Duke vs Mercer in First Round of 2014 NCAA Tournament
More in College Sports
Kansas Jayhawks vs Eastern Kentucky: NCAA Tournament Game Announced
Michigan vs Wofford Men's Basketball: First Round Game of 2014 NCAA Tournament
Arizona Wildcats vs Weber State in NCAA Tournament 2014 First Round
DURHAM, N.C.—Atlantic Coast Conference tournament runner-up Duke will remain close to home to open the NCAA tournament, earning the third seed in the Midwest Region.
The Blue Devils (26-8), who lost to Virginia in Sunday's ACC championship game to Virginia, will face No. 14 seed Mercer (26-8) on Friday in Raleigh, N.C.
Mercer earned its first berth in the NCAA tournament since 1985 with a win over Florida Gulf Coast in the Atlantic Sun tournament championship game.
Duke, led by standout Jabari Parker, was third in the ACC during the regular season. The Blue Devils were a No. 2 seed in last year's NCAA tournament, losing to eventual national champion Louisville in the regional final.


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Any good Chinese or Korean Buffet's anywhere?
- f
- foodluvngal Aug 20, 2006 12:57 AM
My brother and his family, (who I still believe is the family portrayed in the sitcom Roseanne) will be visiting from Arizona in a few weeks and they proudly proclaim their favorite cuisine to be "All You Can Eat." That said, they love Asian cuisine, particularly Chinese and Korean, so I'm trying to find a place to take them that they'll enjoy and that I'll, at the very least, be able to tolerate. Manhattan? Brooklyn? Flushing? (I did try a place on the corner of 60th Street and 17th Avenue in Bensonhurst that was All You Can Eat Korean/Sushi, for like $20/person, but I'm sure they make their money based on the fact that the food is so bad that it's impossible to eat all you can eat. Ugh.)
These two might be worth trying:
1) Arang - inexpensive Korean. Lunch 9.99 Dinner 12.99 My recent review: http://www.chowhound.com/topics/show/...
2) Todai, formerly Minado - Japanese, seafood with some Chinese and Korean dishes. Lunch 13.95, Dinner 23.95. Much larger selection than Arang.
Both are on 32 St in Manhattan.
re: Pupster
Arang is pretty terrible . The sushi looks really suspect, like it's been out there for awhile. The other food is generally dry.
When todai was known as minado it was pretty bad as well.
East buffet in queens is good as the rest of the posters have mentioned.
I haven't been there myself, but East Buffet in Flushing always comes up in these discussions.
East Buffet in Flushing on Main St. is definitely worth a visit. Hundreds of different Chinese fare (particularly good Peking duck that chefs carve by hand when you want it) is around $25/pp. If your family would rather stay within Manhattan, Yakiniku Juju on 28th St. is very popular and also within the same price range, and they serve AYCE Korean/Japanese BBQ. Enjoy!
Thanks, everyone, for all the info. I'm on my way to try them out b4 my brother and his brood arrive.
There is one really good Korean buffet (rare) in Fort Lee NJ.
For $20 I had a feast and it was good quality food. I even got a plate of short ribs from the kitchen. In addition they serve sushi and ice cream. But there was quite a large selection for the buffet. I'm a person that doesn't like buffets, but I would definitely go back here. This place is mostly koreans and is right next to
Plaza Diner Restaurant
2045 Lemoine Avenue
Fort Lee, NJ 07024
You drive in a garage. Once you walk in you have to walk up the stairs and you will see the buffet on your left and to the back. I only went here for dinner. The place is almost all Korean so its authentic. They speak english.
I know that this is a bit late for the "Roseanne" family from AZ, but since foodluvngal included Flushing and Buffet and Korean, the best bargain is Picnic Garden on Northern Blvd in East Elmhurst. The owner claims that this is one of the only Korean Barbecue Buffets in NY and all of the boroughs. Lunch is a bargain at $12.99 and the meat is uncooked, just bring it back to the table and cook it on the grill in your table. I dine alone when travelling on business, so many Korean BBQ's won't light the grill for a single. Plenty of salads, appetizers, soup to go along with the BBQ.
There is a good one for $20 for dinner in Fort Lee, NJ. I don't have the name of the place. But its right next to Plaza Diner on the right (if you are facing Plaza Dineron Lemoine). They got valet parking and you have to walk upstairs. I went on a Sunday and saw this large buffet. They even have sushi and some women bought us over a plate of short ribs. It was a real steal for $20.
Plaza Diner Restaurant
2045 Lemoine Avenue
Fort Lee, NJ 07024
apparently, from what i have heard, the 17th avenue and 65thstreet bbq buffet called big house got shut down for some reason. i think because it's too pricey and no one really want to go to eat buffet for 20 bucks with only little portion of food to choose from. i actually like the little place but whenever i go there, it seems that our table was the only table that exist in the whole restaurant. which is kinda ackward, while everyone keeps looking at you.. too bad it got close.
International in Garden City, Long Island might be the answer for you, if you are willing to travel 30 min out of the city. It's $15 all you can eat and the fare is pretty tasty, they also have oysters, clams, huge crab legs and lobster included.


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Kunis and Kutcher go sightseeing in Sydney. Plus: Eva Longoria, John Cho, Jennifer Garner and more
Credit: Xposure
Published: Friday Nov 02, 2012 | 05:00 PM EDT
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After hitting the town with her rumored new beau, Pippa Middleton enjoys another night out in London on Thursday.
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Lake Buena Vista Condo Rental Photos and Description
2 bedrooms, 2 full bathrooms,sleeps 4-6
Two short miles to the Disney Theme Parks!
2 bedroom suite with 2 full baths, full kitchen and additional sleeping space in living area.
All the comforts of home are offered to you on your getaway vacation. Lake Buena Vista luxury resort offers free shuttle service to your Disney experience. Onsite restaurant, spa,grocery store. Lake Buena Vista Factory Outlets feature 238,000 square feet of brand name stores. Only 4.5 miles to Sea World which your family will love!
- Suitability:
- Long-term Renters Welcome
- children welcome
- non smoking only
Why Pat D'Ambrose chose Lake Buena Vista
Our family comes downto the Orlando area often and this resort id so close to all the them parks its co convenient we just love and you will to


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Developments, news and strategies for drug development specific to phase I through Phase III global clinical trial management, execution, project management and outsourcing. Go→
News, articles and issues specific to clinical trial practice and implementation at the investigative site level. Go→
Strategies and innovations related to how clinical professionals are utilizing technology internal and external to their organizations to advance clinical trials. Go→
News, articles and issues specific to laboratories role in the clinical trial, including ECG, imaging, genotyping, tissue samples and more. Go→
News, developments and strategies for clinical trials conduct in relation to the FDA, EMEA and other global regulatory authorities overseeing the drug development industry. Go→
News, articles and strategies related to clinical trial design which impact postmarketing studies, therapeutic areas, adaptive trials, statistics, protocols and more. Go→
4A: In India, the primary driver for clinical trials is cost-savings, which runs upwards of 50 to 60 percent as compared to trials in the U.S. However, government and regulatory rules are changing very quickly, more quickly than foreign pharmaceutical companies can keep up. Guidelines for audio-video recording of informed consent have been implemented, trial registration has been mandated, a call for compulsory accreditation of independent ethics committees has been answered, panels of experts for clinical trial application approval and serious adverse events reviews have been compiled, GCP compliance is being ensured by India's new clinical trial inspection program, and safety update reports are required to be submitted every six months during the trial. Coupled with lost patent cases by Novartis, Roche, Merck, Gilead, and Pfizer in the country, have led to a decline in trials initiated in India since 2010.
SOURCE: Thomson Reuters Cortellis Competitive Intelligence
Read the full report here.


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Tags indie, indie rock, indie pop, indie electronic, indie dance
Genres indie, rock, alternative, indie rock, singer-songwriter (beta)
(flag as incorrect)
August 11, 2012
Indie- Pendent Music from Bloc Party, The Vaccines, Exitmusic, and a lot more.
Throwback Guiltiest Pleasures Pt. 3 by StraightFromGammaRay
Music from the 70's and 80's.
70s, 80s
Throwback Guiltiest Pleasures Pt. 2 by StraightFromGammaRay
Best of 70's and 80's.
80s, 70s
Throwback Guiltiest Pleasures by StraightFromGammaRay
Selected Music form the 70's and 80's.
80s, 70s, throwback
French Revolt! by StraightFromGammaRay
French Electronic Music from.
french house, french electronic, french house/disco


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Photos and Description of this 1 bedroom holiday apartment in Carre d'Or - Nice Opera Loft
2 full sized beds and a sofa sleeper. Sleeps six comfortably
Best location on the French Riviera. Bright and beautiful loft with all the amenities right in the thick of it. Under one minutes walk to place Messena, the Cour Saleya and Nice beaches. Resturants and shopping are steps from our flat in every direction. The absolute perfect pied de terre for the ultimate Nice experience.
The loft is situated on the second floor of an historic building that once served as a covenant and hospital. It is very near Nice Opera, on the furthest south east corner of Carre d'Or, just 75 feet from Old Town. Major construction for this flat was finished November 2012 and, the design element and finishings we just completed in March 2013. So everything is in brand new condition. Ideal for a family of four. However, there is a sofa bed that could offer two additional persons with a place.
Features include:
4 meter ceilings, in floor heating, 100% LED lighting, built in LAN, 51' flat screen LED TV, WIFI, Apple TV, dual docking station for iPhone 4s and older devices. WASHER/DRYER, dish washer, oven, microwave, induction stove top, glass shower, solid oak flooring and Italian tiles. There are two full sized beds in loft area with sofa sleeper in living area. Everything is brand new!
There is also a fully stocked minibar. Price list can be found in the house manual.
This flat puts the WOW in wow factor. Bright and clean, spacious and comfortable. It really is the best location in town. And, the best location if you're looking to make day trips in the area. Under a minutes walk to the upscale shopping in Carre d'Or. Under a minutes walk to the independently owned shops of Old Town. Steps to the outdoor flower market on the Cour Saleya. Plus, the beaches are all under a minutes walk. More restaurants than you could visit in a year. Grocery stores, boulangerie, dry cleaners are all within a minutes walk. The urban explorers dream come true.
Airport shuttle and tram to train station are just steps away. There are also busses to Monaco and Cannes within a few minutes walk. There are four separate velo bleu bike station under a minutes walk from the flat. Also, there are a couple of Auto Bleu car station both within two minutes walk. The electric cars are great way to explore. They only cost 8 euro an hour and give you 120 kilometres of autonomy. The bicycles are free for the first 30 minutes an 1 euro an hour after that. All busses and tram cost just 1.5 euro! So weather you want to check out the beaches just outside or head to Cannes, Antibes, Ville Franche, Monaco and more, our flat truly puts you right in the centre of all the action.
My family and I have been living in center Nice for eight years now. We're here to point you in the right direction and, we have a great product to ensure you experience is the best possible. Coming from Chicago I am always amazed at how every apartment in Nice is just like the next. We really have gone the extra mile to create a beautiful product. It is a one of kind flat. And, this truly is as good as a location you could get. We are confident that if you are looking for a city center pied de terre than we have a great product for you. If you are coming from a country setting please keep in mind this flat is in the hyper center of town. Come stay with us, we look forward to your booking.
Also included:
Body soap
Hand soap
Bathroom towels
Bed linen
Iron and ironing board
Hair dryer
Pots and pans
Plates and bowls
Drinking glasses
Coffee cups
Knives and cutting board
Kitchen towels
Coffee and tea
Hot water kettle
**Please review house rules for check in and check out times, cash key deposit and other conditions**
Details for holiday apartment Nice Opera Loft, 1 Bedroom, Sleeps 6, 1 Bathroom
- Suitability:
- Events Allowed
- children welcome
- non smoking only
- pets not allowed
- wheelchair inaccessible
About Frank and Aurelia
We are a French American couple with three daughters. When we realized that would not be able to retire before 70 we decided to take action and put our future in our own hands. We spent a considerable amount of time considering several industries that fit our skill set and fit within the framework of our community. One day Aurelia came across this article about new holiday rentals. So we spent several months researching it and another two years finding the right property. Than we spent another six months buying and completely gut rehab'ing this fantastic flat next to the beach and right in the middle of the two best neighborhoods in Nice. We have now been renting the loft since November 2nd of 2012. After our first year we have only had 14 nights without guests and we love it. We have maintained our five star rating from the 30 reviews we have received from our guests. This experience could not be more rewarding. One year later and we finally fee comfortable enough to buy our own advertisement via Homeaway. So as of November 2013 we are here. We hope you and your family will give us the opportunity to earn your business. And, give us the opportunity to show you what everyone loves about our flat and location. We hope to see you soon.
Frank and Aurelia purchased this apartment in 2012
Why Frank and Aurelia chose Carre d'Or
It took us two years of active searching to find this perfectly placed property. It really is the best location in town. We planned out and built an excellent product, as you can see in the pictures. Everything was built with the guest in mind, we have added amenities that just don't exist in any other property in the area. This flat was purposefully build with the holiday guest in mind. It's a trifecta, great flat, great location, and great hosts. Everything is brand new. The furniture, the appliance, everything is new. Through in the 4 meter high ceilings and large spaces and having everything just outside the front door and you will love it here too.
What makes this apartment unique
It is so hard to find a flat in this great of an area. Everything the Côte d'Azur has to offer is right here. But we also have added unique features like Apple TV, Air printing, TV with movies in your native language and a complete kitchen. Plus, you get to enjoy the most well thought out loft in the area. Give us a chance and send us an inquiry today.
Guestbook comments from the owner
We thought the house was very modern and clean. Just be careful when you are using facilities at this place. We ended up paying 40euro for chipping a plate and a tiny scratch on the wall. If you are over 6.2feet tall you will be struggling to be comfortable in this place. Overall good location, close to the beach and wonderful host. *** HOST REPLY*** The 40 euro was for a hole in a wall.


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Latest Posts in Ebay Watch
21 September 2007
Shoes and charity are a way to a conscious woman's heart for sure. eBay are bringing great news for girls with room in their heart for more than just shoe love with their Red Shoe Initiative. The cause aims to promote health and awareness of America's biggest
4 May 2007
I know at Shoewawa we make fun of Jessica Simpson's footwear range almost as much as we make fun of Irregular Choice for having an apt name, but the truth is I actually own a pair of Jessica Simpson shoes...and I love them. I'm not proud of giving in to the cash
17 April 2007
You may be able to get a good bargain on eBay.co.uk, but right now savvy Brit shoppers should be looking across the Atlantic for bargains. Yesterday the pound was worth almost two dollars, the strongest it's been since 1992, meaning we can nab amazing bargains
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- What are the biggest footwear mistakes to make? We discuss...
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All valedictorians and salutatorians are, of course, impressive, if only by virtue of the inherent definition of being at the top of their class. But spend time with Sonoma Valley High School valedictorian Christina Uzzo and salutatorian Jack Murphy, and you're instantly convinced that they are extra special. Their intelligence is obvious, and their optimism is so pervasive, you can't be in their orbit without believing it's a promising world out there and we're blessed to be sharing it with them.
Christina has been number-one since her freshman year, although early on there were others who shared the spot with her. "I'm not competitive," she said, but once she entered advanced placement classes as an upper classman, there was no catching up with her. She is graduating with a 4.27 grade point average.
Jack, on the other hand, said he didn't know and never gave a thought to where he placed, and it wasn't until he examined his transcript while applying to colleges that he realized he was second in his class.
So he humbly said he's not disappointed to be coming in second, with a 4.26 because, "I never knew I was in contention. I always wanted to get good grades but I didn't think I would end up at number two. I was shocked. I didn't think I was that high."
For young adults who would have every reason to be maybe a little bit cocky, these two are brilliant yet understated. Their smiles are constant, and "honored" and "appreciative" seem to be their favorite words.
"I've always been really motivated and I've always loved school," Christina said. She is a lifelong avid reader who attended Sassarini Elementary and Adele Harrison Middle School and can't wait to go to the University of Chicago, her first choice, in the fall. She will major in either English or comparative literature, with a minor in human rights. She hopes to someday be a teacher or an educator with a nonprofit, possibly in a foreign country. She was also accepted to UCLA, but didn't seriously consider going there because she thought it was too big and she was looking for a change by going out of state.
Jack is an athlete who played varsity baseball and basketball, and his favorite high school classes were metal shop and physics. "It seems like physics is everywhere, and I like the applications."
He started school at St. Francis, switching to Prestwood Elementary and Adele Harrison Middle School. He plans on playing intramural sports at the University of Michigan, where he will major in mechanical engineering. He seriously considered UCLA, but like Christina, he wanted to leave California.
They each expressed an intrigue about living in cold weather that one might guess will quickly lose its allure once experienced.
Both Christina and Jack are excited about making their commencement speeches, and neither of them is particularly nervous. Christina, who adores Jane Austin and was never interested in playing sports, has been on the mock trial team since freshman year, giving her many opportunities to speak in front of an audience.
She also gave a speech at Girls State in front of about 600 people, in which she noted, "George Washington said we should avoid partisan politics or it would be the death of this country."
Jack served as the financial advisor on the Leadership team this year, and gained speaking experience when running for the slate last year and while helping to organize the elections this year. "It taught me a lot," he said, and now he is just "a little bit" nervous about his speech tonight. "I do want to make it a bit humorous," he said.
"I am so excited to be able to speak to my class about what high school meant to me," Christina said. She will also be looking to the future in her speech, and is not giving anything away in advance. "I'm keeping it a secret," she said.
Jack describes himself as someone who was "the quiet guy" in his earlier years, but who "at the end of last year and this year I really started to put myself out there and started developing better personal skills." He was pleased and surprised when we was chosen as Homecoming King. "It was really cool to be honored," he said and described the experience of being on the float in the parade as "surreal."
Christina was "shocked" when she was chosen as prom queen. "I felt like I must be liked and it made it easy to think that being a nerd is OK," she said. (Although there also may be genetics involved, because her mother was once the prom queen at Justin Sienna.)
Jack and Christina each heaped praise on their parents for all the support given them towards achieving their academic success.
Christina said her parents, Mark Uzzo and Allyson and Mark Etherington have been wonderful. "They are all very hard working and very kind. They are all very involved in my life. They have really shaped me as a person and gave me their support and worked with me to help me get to where I am," she said. She is also very close to her sister, Kimberly, 14, and has a grandmother, Kaeti Bailey, who lives in the Valley and is always there for her.
Jack had heartfelt praise for his parents, Jim and Kathy Murphy. "They always encouraged me and supported me, but they have never pressured me," he said. "I am an absolutely huge fan of my Dad, he's the best," he said about his father, who is an Academy Award-winning animator at Pixar. "I love my Mom. She laughs at all my jokes and she's never mean to anyone." Jack has a brother he looks up to, William, 19, who is a student at Marquette University, and a "great sister" Louise, 14, who he said is an amazing horseback rider.
Even though they can't wait to get to college, Christina and Jack each talked about how hard it will be to leave their families in the fall.
"I know it will be hard. But I'll be home over the holidays and we'll be in touch a lot with Facetime and texts. We're so close, we'll be able to stay in touch well," Christina said.
Jack knows his parents and sister will be sad to see him go. "I do think they'll miss me, but I don't think they'll miss the amount of food I eat."
Until tonight, no one knows exactly what Christina and Jack will have to say to the graduating class of 2014, but surely somewhere in their sentiments will be their love for Sonoma and how much they enjoyed growing up here. "I love Sonoma," Christina said, and Jack added, "I can't imagine a better place to live."
Even as they head out to Chicago and Michigan, with exciting challenges ahead, Sonoma will always be home.


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Today's favorite place is from Kristin Addis of Be My Travel Muse
Kristin's Favorite Place: Taiwan
Why She Loves it"Many people travel to Asia, but few stop by Taiwan. This island is full of friendly people, amazing food, and beautiful landscape. Taipei is a beautiful mixing of East and West, and the rest of the island offers beautiful beaches in the South, winding canyons in the middle, and beautiful, mystical lakes."
Kristin's Favorite Things to Do and See in Taiwan
About Kristin
I'm a former investment banker who quit my job, sold all of my belongings, and bid the life I knew goodbye in favor of becoming a solo nomad in Asia. I'm a SCUBA addict, humble student of Mandarin, and above all, an adventurer. I plan nothing, and simply let things fall into place.
Find Kristin: http://www.bemytravelmuse.com/ & @bemytravelmuse


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What does LAC mean in US Government?
This page is about the meanings of the acronym/abbreviation/shorthand LAC in the Governmental field in general and in the US Government terminology in particular.
Legislative Audit Commission
Find a translation for LAC in other languages:
Select another language:
What does LAC mean?
- lac(n.)
- a resinous deposit secreted on certain trees by a female scale insect, Laccifer lacca, of S Asia, and used chiefly in varnishes.
Discuss this LAC abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"LAC." Abbreviations.com. STANDS4 LLC, 2014. Web. 27 Nov. 2014. <http://www.abbreviations.com/term/117013>.
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Friday, March 2, at College Park Center, Arlington
At the end of last year, I took back misgivings I had about Drake since his studio debut, Thank Me Later, dropped a couple years back. One of reasons I changed my mind "aboat" the Canadian rapper was the title track from his sophomore album, Take Care, released last year. "Take Care" follows a chai ... More >>
Brides run circles around doomed grooms in DTC's rough 'n' tumble Big Love
Elvis Costello and Burt Bacharach are not such unlikely partners


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New Israeli tech toy takes kids away from screens and into books recorded by parents, grandparents or even themselves.
20 top things to do during the winter in Israel
Ski in the Hermon, watch the migratory birds, see the holiday lights, dance the lindy hop … there's plenty of fun to heat up chilly days.
Oud players string together Arab and Jewish culture
Jerusalem's International Oud Festival marks its 14th year with songs and melodies from a cross-section of traditions.
'We brought Israelis back to the movies'
Renen Schorr explains how Jerusalem's Sam Spiegel Film and Television School saved Israel's film industry and propelled it to international acclaim.
Artsetters, setting global style trends
Lebanese hipsters are wearing Israeli fashion, thanks to a new cross-border ecommerce site based in Tel Aviv.
NightRun Tel Aviv
Tel Aviv has a marathon too, but the NightRun gives a whole different vibe to the scene as thousands of runners hit the streets.
The top eight things to do in Israel on the eight days of Hanukkah
ISRAEL21c brings you eight awesome ideas for celebrating the Festival of Lights in Israel, where it all happened back in the year 165.
Eight fun facts about Hanukkah
Do you know where the word 'dreidel' comes from, and how many calories are in a sufganiya? ISRAEL21c has the answers.
Omri Amrany, sculptor of sports stars
Best known for his iconic images of American pro athletes, the kibbutz-born artist
and his wife run a successful fine-arts studio and school in Chicago.
Dogs go wild on Tel Aviv's first ever four-legged marathon
Tel Aviv's first ever Doggie Run gets pet owners and their dogs out into the sunshine for a good workout and lots of fun.
Bar-Ilan's new haredi dean of exact sciences
Prof. Malka Schaps may be the first ultra-Orthodox woman to climb this high on the professional academic ladder.


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Breaking through the mythology.
The Truth about Abraham Lincoln & Slavery
The Appeaser
The Limits of Power
Herbert Daughtry
Called the "People's Pastor" for his long activist career, Herbert Daughtry in 1953 was convicted of armed robbery and assault charges. In prison, he had a religious conversion to Pentecostalism which led him to become a pastor in Brooklyn, New York. In 1980 Daughtry helped establish the National Black United Front, which helped organize the national campaign for reparations and has worked alongside the […]
Poll: 7 in 10 Afghans support US forces – AP
Jacob Laksin is a senior writer for Front Page Magazine. He is co-author, with David Horowitz, of The New Leviathan (Crown Forum, 2012), and One-Party Classroom (Crown Forum, 2009). Email him at email@example.com and follow him on Twitter at @jlaksin.
Nearly seven in 10 Afghans support the presence of U.S. forces in their country, and 61 percent favor the military buildup of 37,000 U.S. and NATO reinforcements now deploying, according to a poll released Monday. Support for U.S. and NATO forces, however, drops sharply in the south and east where the fighting is the most […]
Religious Climate Rage – by Mark D. Tooley
Mark Tooley is President of the Institute on Religion and Democracy (www.theird.org) and author of Methodism and Politics in the Twentieth Century. Follow him on Twitter: @markdtooley.


text: Custom T-Shirts for ruby princess Life is Better Sliced by Rich - almost 2 years ago "This photo was taken of our children as our two families pulled out of Port Everglades on the Ruby Princess for a New Year's Week Caribbean cruise. I love CustomInk!" view full details Back to the top


text: Is it necessary that I Free and re-Create my various (SW_SURFACE) surfaces if I change video mode? My program seems to work without this step, but the docs aren't explicit and I can't be sure this isn't just a freak of the particular platform I'm developing on . . . -Thomas


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Print Options
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Raspberry Iced Tea >
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Nutritional Facts
Select reviews >
Raspberry Iced Tea
One sip and you'll likely agree this is the best flavored tea you've ever tasted.—Christine Wilson, Sellersville, Pennsylvania
8 Servings
Prep: 10 min. + chilling
8-1/4 cups water,
2/3 cup sugar
5 individual tea bags
3 to 4 cups unsweetened raspberries
In a large saucepan, bring 4 cups water to a boil. Stir in sugar
until dissolved. Remove from the heat; add tea bags. Steep for 5-8
minutes. Discard tea bags. Add 4 cups water.
In another saucepan, bring raspberries and remaining water to a boil.
Reduce heat; simmer, uncovered, for 3 minutes. Strain and discard
pulp. Add raspberry juice to the tea mixture. Serve in chilled
glasses over ice. Yield: about 2 quarts.
Nutritional Facts:
1 serving (1 cup) equals 87 calories, trace fat (trace saturated fat), 0 cholesterol, trace sodium, 22 g carbohydrate, 3 g fiber, trace protein.
© Taste of Home 2014


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- Adult Adventure
- Some Body Parts
- Tools and Tapers
- Straight Barbells
- Accessories
- Curved Barbells
- Replacement Parts
- Captive Bead Rings
- Earlets & Tunnels
- 14k Gold Only
- Ear Plugs
- Segment & Seamless Rings
- Spirals & Claws
- Organics
- Charms
- Hide Your Piercing
- Circular Barbells
- Genuine Diamond Jewelry
- Screwball Rings
- Fixed Bead Rings
This piece is a traditional piece as well. Very popular, and looks wonderful no matter what you are wearing. This piece can be dressed up or worn with a swimsuit and still look good. The gem is 6mm in size and this piece really will go with everything.
The Gold used in this Piece is Totally Nickel Free, and available in either; solid 14K Yellow Gold, or solid 14K White Gold.
The Gems used are Genuine Swarovski Cubic Zircons. They are all hand set, Not just glued in as with most companies.
Naturally we can replace the Cubic Zircons for any Genuine Precious Stones you would like, as you can see on our Genuine Gem Page. Just email us if we can help with anything.
You may also be interested in the following product(s)
Genuine Diamond Ball Set - Curved Barbell
Regular Price: $345.99
Special Price: $311.39As low as: $301.39
Genuine Diamond Double Prong Set - Curved Barbell
Regular Price: $779.99
Special Price: $701.99As low as: $691.99
Genuine Diamond Prong Set Solitaire - Curved Barbell
Regular Price: $289.99
Special Price: $260.99As low as: $250.99
Customer Reviews
- Untitled Review by Amber
Beautiful piece, but I didn\'t measure properly! The chain gang was very accommodating- and I measured this time and I am very excited to see this piece in my piercing!
(Posted on 2/29/12)


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Desert Manor
View property, WalkScore, and Driving Directions
Desert Manor is located in the central area of Las Vegas, NV with easy access to both I-15 and the I-95 freeways. We offer fully furnished studio apartments for rent. Amenities include our friendly on-site management team, free cable, sparkling pool, utility allowance, extra storage, internet access, on-site laundry facility, full kitchens and our gated access community is close to everything Vegas. Fine dining, entertainment and shopping. Small pets are welcome and we are on the CAT Busline.
Furnished Studios in Downtown Las Vegas!
Floorplans and Pricing
|Plan A
|1 Bathroom
|$570 - $610
|Check Availability
Features and AmenitiesBack to Top
Special Features
- On-Site Management
- Furnished Studios
- Free Cable Television
- Gated Access Community
- Sparkling Pool
- Utility Allowance
- On-Site Laundry Facility
- Extra Storage Available
- Kitchenettes
- On CAT Busline
- Close To Everything Vegas!
- Local Telephone Service Included in select units
Community Features
- Bilingual
- Controlled Access
- Corporate Housing
- Courtyard
- Covered Lot
- Disability Access
- Efficiency
- Freeway Access
- Hablamos Espanol
- Laundry Facility
- Pool
- Public Transportation
- Short Term Lease
- Studio
- Surface Lot
Apartment Amenities
- Air Conditioning
- Cable or Satellite
- Cap on Utilities
- Carpet
- Dishwasher
- Extra Storage
- Furnished Available
- Garbage Disposal
- Internet Access
- Water Sewer and Trash
- Window Covering
Additional Information
Apartments in Community: 188
Pet Policy
Your small pet is welcome! Size and breed restrictions apply. One pet per studio
- Cats Allowed
- Pets Allowed
- Small Dogs Allowed
Local Schools
- Howard Hollingsworth Elementary School
- John C. Fremont Middle School
- Rancho High School
We believe school data to be accurate, but do not guarantee that. Please be sure to verify where your children will attend school before making your housing decision.
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.


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This guy's wings are a bit chewed up. I guess he was the loser of a territory battle.
The Eight-spotted Skimmer (Libellula forensis) is a dragonfly of the skimmer family.


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Full CoverageLive Video
Car slams into garage, through fence and into houseUPDATED 6:55 AM CDT May 01, 2013
Ankeny police said a woman was injured inside her home when a driver slammed into it Tuesday night.
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Steve Doocy's file
Journalist from New York
Steve Doocy is a host of the Fox and Friends program on the Fox News channel.
Doocy's statements by ruling
Click on the ruling to see all of Doocy's statements for that ruling.
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"If you make more than $250,000 a year … you only really take home about $125,000."
— PolitiFact National
Steve Doocy
White House Political Director Patrick Gaspard once served as the "right-hand man" for Bertha Lewis, who heads up ACORN.
— PolitiFact National


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Documentary Center brings agony of child marriage to light
By Shant Shahrigian
The word surreal comes from combining the French words for "on" and "real" to signify something that is more than real or beyond mundane life. It also connotes paradox, the concurrence of two or more contradictory realities that can produce disorientation, confusion, nausea.
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Save to My Recipes
Maw Maw Hinson's Tomato Gravy
Servings: 2 cups
- 1 1/2 pounds tomatoes, cut into 2-inch pieces
- 1/4 cup (1/2 stick) unsalted butter, cut into 1/2-inch pieces
- Kosher salt, black pepper
Nutritional Information
1/3 cup per serving, 1 serving contains:
- Calories (kcal) 90
- Fat (g) 8
- Saturated Fat (g) 4.5
- Cholesterol (mg) 20
- Carbohydrates (g) 4
- Dietary Fiber (g) 1
- Total Sugars (g) 3
- Protein (g) 1
- Sodium (mg) 85
PREPARATIONView Step-by-Step Directions
Bring tomatoes and butter to a simmer in a large skillet over medium heat. Cover, reduce heat to low, and simmer gently, stirring occasionally, until tomatoes are softened, 35-40 minutes. Season with salt and pepper.
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The Bagel Whisperer
Chef Alex Bois is churning out some of the country's best bread and bagels. We get a look inside his process
Take the Adventure Path
Camping and picnic food don't need to consist of dried-out potatoes and store-bought macaroni salad. Make dining al fresco fresh again
Out of the Kitchen
Welcome to our ongoing exploration of America's coolest food artisans. We'll be bringing their knowledge and expertise back to our home kitchens—and to yours.
All Hail the Hot 10!
From a food truck to a "pastry luncheonette," these are the Best New Restaurants in America
Turkey GravyThe turkey and dressing may get all the attention, but it's gravy that makes the meal. Our three-step, do-ahead version helps everything taste better.
Hard-Cider GravyYes, gravy should be lump-free (always whisk, don't stir), but it's the flavor of the roux that makes or breaks what gets passed at the table. Toasting flour in butter is what develops its deep, nutty taste. You'll know it's done when it's the color of graham crackers and smells like popcorn.
Olive-Orange Vinaigrette
Mojo Verde
Mojo RojoUse this smoky, chile-based Mojo Rojo sauce to add color and heat to blanched cauliflower, green beans, or broccoli.
Zingy Red Sauce


text: Rose Parade Crowd Boos Occupy Bullies by Susan Swift 2 Jan 2012 post a comment Share This: Boos greeted the post-Rose Parade Occupy protestors on Monday. Boos and empty bleachers. Traditionally, when the last float, band and equestrian unit in the Rose Parade passes and the parade concludes, what follows are janitors scooping up horse manure, along with individuals and groups hyping various political, religious and sundry causes. As reported in earlier articles, this year's post-Rose Parade tag-alongs included a contingent of "Occupy The Rose Parade" malcontents with a hodgepodge of pathetic "floats", including a cheesy plastic bag "octopus of greed." [youtube Vdl6mrVXu7s&context=C3e4267aADOEgsToPDskKFmeHJLLKWSvTQBd3pqYE0] My sister-in-law took video from the stands at the beginning of the parade route. The crowd had not yet had a chance to disperse following the parade, so they booed the Occupy protesters. Further down the route, the crowd simply dispersed and ignored them. My husband and daughter also attended the Rose Parade, and afterward when they attempted to get to their car among the dispersing crowds on Colorado Boulevard, they encountered the oncoming Occupy "paraders". But rather than allow them and other spectators to walk freely, the Occupy mob literally attempted to shove my husband out of the way of their "parade". When he didn't accommodate them, he and my daughter were verbally abused by the Occupiers who walked through them with their banners and silly plastic octopus. And while disgraced lawyer, convicted thief and failed political Democrat candidate claimed a loyal following of 5000, it was obvious that the Occupy mob numbered no more than one or two hundred, many of whom were probably dispersing parade spectators. The Occupy organizer (supposedly trained in crowd safety) tried to shove my husband out of the way, but like a typical bully he stopped when warned against such behavior. Then my husband fumbled to begin taping in the middle of the event (thank Steve Jobs for such amateur video protection devices!). His portion of the amateur video starts inside the belly of the beast. On the audio, you can hear the Occupy mob organizer being derisive. Occupod organizer: "We have a very disabled individual here who doesn't like the parade." "He's having a panic attack." "This poor man doesn't understand what's going on. We've gotta help this poor man out." "There really is actually a fine for disrupting the parade." My husband responded: "Except this isn't the parade, is it?" The Occupod continued (apparently, they don't like their parade disrupted by protesters): "You are really a destructive guy." "Please make way for this individual who is demanding that we part for him. Let's just be gentle with this poor man who doesn't understand what's going on." The shameless hypocrisy of the so called 99% is palpable: they believe that they are the only ones entitled on a public street and all others must make way for them. These are the same people who routinely blocked streets and intersections, disrupted businesses, took over public parks for months, raping and defecating along the way, preventing the free comings and goings of others. What their behavior demonstrates is the shear arrogance of the Occupy activism, their utter disdain for the law and the rights of others. It is they who are the one percent attempting to dominate with their fringe message of socialist control ably aided by the Make-Believe Media.


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|Ramada Hotel Siegen Kampenstraße 83, 57072 Siegen, Germany (2.9 miles from Achenbach)
Score from 308 reviews: GoodThis 4-star hotel is in the heart of the university city of Siegen. A 10-minute walk brings you either to the main train station or the picturesque Old Town. More…
$69 Average price per night
|Hotel-Pension Alt-Heidenberg Achenbacher Straße 120, 57072 Siegen, Germany (1.2 miles from Achenbach)
Score from 32 reviews:Surrounded by mountains and woodland in the picturesque countryside of North Rhine-Westphalia, Hotel-Pension Alt-Heidenberg is located in the town of Siegen. Free WiFi access is available in all... More…
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|Berghotel Johanneshöhe Wallhausenstraße 1, 57072 Siegen, Germany (1.4 miles from Achenbach)
Score from 69 reviews: GoodThis 3-star hotel is located in the Achenbach district of Siegen, with a panoramic view of the city. Berghotel Johanneshöhe offers modern rooms with free Wi-Fi internet. More…
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|Stadt-gut-Hotel Siegboot Eiserfelder Strasse 230, 57080 Siegen, Germany (1.7 miles from Achenbach)
Score from 31 reviews: GoodThis family-run hotel offers free parking and a sauna. The 3-star hotel and the restaurant were renovated in early 2010. It is in southern Siegen, between a business park and a wooded hill. More…
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|Gasthof zur Post Eiserfelderstr 399, 57080 Siegen, Germany (2.1 miles from Achenbach)
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|Hotel Schäfer Roster Straße 111, 57074 Siegen, Germany (2.2 miles from Achenbach)
Score from 74 reviews: GoodJust 5 minutes from the A45 motorway in Siegen, Hotel Schäfer offers welcoming rooms with flat-screen TVs. There is a cosy on-site bar and a restaurant serving regional and international cuisine. More…
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Welcome to The BRIDGE, the social and information hub of the dental lab industry. Connect with industry peers and vendors, ask questions, sign up for events, review products, read LMT articles and industry news and more!
Bennett Becvar, CDT commented on Andre Michel's photo
Really nice case, especially considering the spacing of the maxillary centrals. The layering and contours...(more)
Bennett Becvar, CDT commented on Michael LaRocque's reply
Michael, when you put in as much time as this work requires, you have to get out and see the sun shine...(more)
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Hi Dennis, I have always carried business insurance from a company through the Sebrite Agency (NADL)...(more)
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text: Paradocx moved their tasting room/bar to "The Liberty at Market Place" in downtown Kennett Square. The winery is in Landenberg, PA. Paradocx makes a great variety of local wines and is one of my favorite local wineries. Their new tasting bar is a great place to taste their wines or hang out in the evening and get food and dessert... More


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Limerick City of Culture
»This autumn, get in on the action as Limerick continues its year as National City of Culture.
Autumn adventures
»Whether it's a gentle stroll or a daring dive, autumn's the time to get out and about for the adventure of a lifetime. Find information on adventure tours, climbing and games.
Historic houses
»The historic houses of Ireland offer guests the chance to sample the rich heritage of the countryside.
Search what's on
»This autumn, find an event to suit you, whether it's a day at the races or a film festival.
Explore special offers
»Great value quality breaks await you in Ireland so find the one just right for you.
»Start your search for the perfect Irish break now. What's stopping you?
Clarion Hotel Sligo
WINTER PACKAGES: €129pps – 2 B&B+1 Dinner. This is a weekend offer, valid January 1 to March 31, 2012.
Located on the outskirts of Sligo Town and overlooked by the majestic Benbulben Mountain is the Clarion Hotel, Sligo. Dating back to 1848 and designed by William Dean Butler, the Clarion is a landmark building boasting a striking granite exterior, which has been sensitively restored and remodelled as a beautiful, contemporary, four-star hotel.
All standard rooms and family suites are decorated to create a tranquil atmosphere of modern luxury and sophistication. The rooms are complemented by sleek, pristine bathrooms furnished with soft cotton towels and toiletries. These guest rooms feature a full-range of luxury amenities and the latest in technology, including high speed internet access.
Guests at the Clarion Hotel Sligo can enjoy an excellent range of facilities including a choice of restaurants, Sinergie and Kudos Bar as well as the SanoVitae Health & Leisure Centre and Essence Spa.
The Clarion is about a fifteen minute walk from Sligo town centre. There are several Blue Flag beaches within a 10 minute drive of The Clarion. Strandhill is renowned for its International surfing. Freshwater and Deep sea fishing is also popular during the fishing season. Other activities and attractions in close proximity include horse-riding farms, Sligo Folk Park, Celtic Seaweed baths, Parks Castle and Lisadell House.
Clarion RoadBallinodeSligoSligoRepublic of Ireland
Discover Ireland is not a booking site but below are your booking options


text: We like how Grigio Glass Canisters by Guzzini® stack up - literally! Each lift-off lid is designed to fit into the base of another canister so you can stack them on a countertop or in a pantry. They keep kitchen staples such as sugar, tea, rice and pasta fresh and ready for use, and you can easily see at a glance what is in each. You'll also appreciate their stylish Italian design, adding practical flair to any kitchen.


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Open Yoga Gallery
by Jeff Finley
Art Print
Collect your choice of gallery quality Giclée, or fine art prints custom trimmed by hand in a variety of sizes with a white border for framing.
Designed this flyer for a new yoga studio with a focus on art and community. The studio will open in Cleveland, OH.
- 9Promote


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It's time again for the prestigious Filmfare awards. Watch the video and check out the nominations in the category. Do let us know which are the films you stand for.
Set in the backdrop of the picturesque Goa, 'Finding Fanny' is an English/Konkani movie. The movie stars Deepika Padukone, Arjun Kapoor, Naseeruddin Shah, Dimple Kapadia and Pankaj Kapur. Check out the trailer right here.


text: 1012 Bacon Street Status: Off Market MLS#: 1831537 Contact Email this listing Share on Pinterest Share on Google+ Share on Facebook Share on Twitter Calculate Mortgage Print Flyer Get Directions Request a Showing Off Market 1012 Bacon Street, Durham, NC 27703 is no longer on the market or has been removed from the MLS. Similar to 1012 Bacon Street: Ask an Agent About 1012 Bacon Street * Required fields Send Your Question × Monthly Payment Estimator Price: Down Payment: % Loan Amount: Loan Type: 30 Year Fixed 15 Year Fixed 5/1 ARM Interest Rate: % Est. Tax & Insurance: % ($/mo.) Est. Monthly Payment: $478 per month × Email a Listing 1012 Bacon Street, Durham NC, 27703 From: Name: Email: To: Name: Email: Subject: Message: Take a look at this property I found on FathomRaleigh.com: http://www.fathomraleigh.com/homes/1012-Bacon-Street/Durham/NC/27703/21840206/ Send a copy of this message to me Send Email


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Tags: Piracy, somalia
The Other Surge
By Jeffrey Withington
Well, what do you know? Somalian pirates are adapting to multinational forces. An "unbelievable" spurt of attacks have marked the past couple of days. This past Saturday a German vessel was seized 400 miles off the coast, bringing the total to 5 vessels captured over a span of 48 hours. And of course today the Maersk Alabama was attacked.
Check out this map of pirate attacks for 2008. Attacks are heavily concentrated in the Gulf of Aden with some attacks off of the east coasts of Somalia and Kenya.
Now check out this map for 2009. Attacks still occur primarily in the Gulf of Aden but a quick glance seems to reveal more attacks four months into 2009 off the eastern coasts of Kenya and Somalia than in all of 2008. I'd love to get my hands on the raw data especially distance from coasts but even a qualitative glance reveals the attacks are shifting further from the coast with more action off the coast of Kenya.
They've changed it up. Will we?
Tags: Piracy, somalia
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They share a goal of achieving excellence in radiology.
Now they are leading the way to success for Radisphere and its clients.
Scott SeidelmannCEO and President
Frank Seidelmann, DOCo-Founder, Chairman & Chief Medical Officer
Andrew WebbChief Financial Officer & Chief Administrative Officer
Jonathan HoukChief Technology Officer
Alexandrea FairSenior Vice President & Chief Operating Officer
Josh SensSenior Vice President of Service Operations


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Hotel Francois 1er, Paris
Hotel -7, Rue de Magellan, 75008 Paris, 7 Rue Magellan, 75008 Paris, France, 7, Rue Magellan, 75008 Paris, Île-de-France, France -3 Stars, 4 Stars -40 Rooms (On Ciao since: 02/2006)
User reviews
Travel > Europe > France > Paris > Paris Hotels
Est Hotel, Paris
Hotel -49 Boulevard Magenta, 75010 Paris, France -3 Stars -86 Rooms (On Ciao since: 07/2008)
User reviews
Hotel Residence Foch, Paris
Hotel -10 Rue Marbeau, 75116 Paris -3 Stars -25 Rooms (On Ciao since: 02/2006)
Holiday Inn Paris Republique, Paris
Hotel -10 Place de la Republique, 75011 Paris -3 Stars -318 Rooms (On Ciao since: 07/2003)
Artus Hotel, Paris
Hotel -34, Rue de Buci, 75006 Paris -3 Stars (On Ciao since: 01/2006)
User reviews
Regina Hotel, Paris
Hotel -2 Place Des Pyramides, 75001 Paris -3 Stars -120 Rooms (On Ciao since: 04/2004)
Chateau Frontenac Hotel, Paris
Hotel -54 Rue Pierre Charron, 75008 Paris -3 Stars -104 Rooms (On Ciao since: 03/2006)
Pavillon De Paris, Paris
Hotel -7, Rue de Parme, 75009 Paris -3 Stars -30 Rooms (On Ciao since: 02/2006)
New Hotel Opera, Paris
Hotel -4 Rue De Liege, 75009 Paris, France -3 Stars (On Ciao since: 03/2010)
Rochester Champs-Elysees Hotel, Paris
Hotel -92 Rue La Boetie, 75008 Paris -3 Stars -90 Rooms (On Ciao since: 01/2006)
Radisson SAS Hotel Charles de Gaulle Airport, Paris
Hotel -Rue de La Chapelle, 77990 Paris -3 Stars -240 Rooms (On Ciao since: 02/2006)
La Villa Saint-Germain, Paris
Hotel -29, Rue Jacob, 75006 Paris -3 Stars -32 Rooms (On Ciao since: 11/2006)
Holiday Inn Paris-St. Germain Des Pres, Paris
Hotel -92 Rue de Vaugirard, 75006 Paris -3 Stars -134 Rooms (On Ciao since: 09/2005)
Mon Hotel, Paris
Hotel -1-3 Rue D'argentine, 75016 Paris, France -4 Stars -37 Rooms (On Ciao since: 07/2008)
Bedford Hotel, Paris
Hotel -17 Rue De L Arcade, 75008 Paris -3 Stars -148 Rooms (On Ciao since: 03/2004)
Concorde Lafayette, Paris
Hotel -3, place du General Koenig, 75850 Paris -4 Stars -966 Rooms (On Ciao since: 03/2006)
Sully Saint Germain, Paris
Hotel -29-31 Rue Des Ecoles, 75005 Paris, France, 31 Rue des Ecoles, 75005 Paris -3 Stars, 2 Stars -61 Rooms (On Ciao since: 07/2008)
Hotel Saint Paul Rive Gauche, Paris
Hotel -43 Rue Monsieur le Prince, 75006 Paris, 43 Rue Monsieur le Prince, 75006 Paris, France -3 Stars -31 Rooms (On Ciao since: 02/2006)
Grand Hotel Dore, Paris
Hotel -201 Avenue Daumesnil, 75012 Paris, France -3 Stars -40 Rooms (On Ciao since: 07/2008)
Hotel Cambon, Paris
Hotel -3 Rue Cambon, 75001 Paris -3 Stars -40 Rooms (On Ciao since: 02/2006)
(*) Reviews by Ciao members
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Beautiful hotel in Paris
Advantages: Central location, quiet area, modern and stylish, delicious breakfast, friendly staff
Disadvantages: -
...We recently visited Paris for a few nights following a trip to the Pyrenees. I did loads of research of hotels in Paris and found that accommodation in Paris is expensive, particularly if you want a central location. I found Hotel Le?A which is a cute boutique hotel and decided to book. I booked the hotel online using the hotels official website. We paid ?220 per night which included breakfast...
21.08.2014 15:47 ·
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Ciao members have rated this review on average very helpful
Review of Hotel Le A, Paris
Oh La La debmercury stays in Hotel Bellevue Paris
Advantages: Excellent location and good value for money
Disadvantages: Not suitable for disabled people
...The Hotel
The Bellevue hotel is a three star hotel and has 36 rooms, which are all nicely decorated in either burgundy or blue tones. It is a four storey building with lots of parisian style.
The hotel is a small independantly run hotel which is in a fantastic location 19 Rue d' orsel, 7518 Paris which is at the foot of the Sacre Coeur church in Montmartre.
I had pre-booked a taxi...
16.05.2009 15:13 (21.10.2012 18:07) ·
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Ciao members have rated this review on average very helpful
Review of Bellevue Hotel, Paris
Advantages: Location, size of bedroom, comfortable beds, cheap Paris prices
Disadvantages: Decor, small lift, no mini fridge in room
...Comprador Hotel, Paris
Well, the school holiday season is with us once again, and holidays seem to be in everybody?s thoughts at the moment.
I was able to spend a few days in Paris recently, and I thought I would let you know about the Comprador Hotel in which I stayed in.
For a long time I have wanted to lose myself in Paris for a few days, as I had...
25.07.2010 16:36 (25.07.2010 16:42) ·
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Ciao members have rated this review on average very helpful
Review of Hotel Comprador, Paris
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Meade - 6" LightSwitch Advanced Coma-Free Telescope
The Meade 6" ACF LightSwitch Telescope is built with both portability and features in mind. One of most noticeable is the self alignment system with the touch of a switch.... Learn MoreFREE SHIPPINGModel#: 0610-03-10(48 States)
Regular Price: $1,599.00
Special Price: $1,399.00
Meade - 7-15x35 Mirage Binoculars
High-Quality zoom binoculars with fully multi-coated optics and porro prisms. Includes nylon soft pouch with carry strap and lens cleaning cloth.... Learn MoreModel#: 125060
Meade - ETX-80 Aluminum Hard Carry CaseFully lined with fitted, foam inserts and accepts the complete Meade ETX-80 & ETX-70 telescope, as well as optional accessories ... Learn More
Model#: 07385
Meade - Wireless long range remote temperature sensor #TS34C-M.Wireless long range remote temperature sensor #TS34C-M. Reads outdoor temperature and humidity and transmits up to 328 feet (100 meters). LCD display. ... Learn More
Model#: TS34C-M
Meade - 30mm Series 5000 Ultra Wide Angle 82° Eyepiece - 2"
Only the highest quality materials were selected to create this amazing eyepiece value, offering an unparalleled vista on the Universe... Learn MoreFREE SHIPPINGModel#: 07663(48 States)
Meade - 12" LX850-ACF (f/8) Advanced Coma-Free Telescope
Meade Instruments proudly introduces the new standard in astrophotograhic and visual performance, the LX850.... Learn MoreFREE SHIPPINGModel#: 1208-85-01(48 States)
Meade - Dovetail Plate for 14 " OTA includes 2 radius blocks and mounting hardwareMeade Dovetail Plate for 14" Schmidt-Cassegrain and Advanced Coma-Free telescopes. Part of the Series 5000 Auxiliary Equipment System. Equip your Meade LX90, LX200, or other SCT or ACF telescope with the best and maximize its performance today ... Learn More
Model#: 07924
Meade - LX200 Control Panel AssemblyCompatibility: LX200 8", LX200 10" and LX200 12" models. ... Learn More
FREE SHIPPINGModel#: 37-7240-01(48 States)
Meade - 5-Year Advance 3-Way Shipping PlanMeade Advance 3 way shipping will allow you to take advantage of Meade's safe double box packing material, that will be sent to you along with a call tag to pick up your telescope ... Learn More
Model#: AS501
Meade - Polaris 90mm German Equatorial Refractor Telescope
The Meade Polaris 90mm German Equatorial is a perfect sized refractor for the beginner astronomer and comes with basic accessories and optics to make the first stargazing experience a memorable one!... Learn MoreFREE SHIPPINGModel#: 216003(48 States)
Meade - MAX Mount Instrument Plate Assembly
The Meade MAX Mount Instrument Plate Assembly is a Telescope Accessory for the Meade MAX Robotic German Equatorial Mount.... Learn MoreFREE SHIPPINGModel#: 07625(48 States)
Meade - Wireless Indoor/ Outdoor Thermometer, Atomic Clock.Honeywell Personal Weather Station Atomic Clock. Reads indoor/outdoor temperature with the single included remote TS13C model sensor with 100 foot (30 meter) range ... Learn More
Model#: TE219ELW
Meade - MA 12mm Illuminated Reticle Astrometric Eyepiece - wireless (1.25")A high-precision eyepiece for a wide range of astronomical measurements ... Learn More
Model#: 07069
Meade - Series 5000 HD-60 18mm Eyepiece - 1.25"This Meade Series 5000 HD-60 Eyepiece is presented in a 18mm focal length with a 1.25" barrel. Offers a large 60° apparent field of view and a flat field of view which is tack sharp right to the edge ... Learn More
Model#: 07734
Meade - #607 Power Cord (25ft.)The Meade #607 Power Cord allows you to power a Meade 7in. - 14in. LX-Series telescope, LXD55/75, Starfinder EQ, ETX-EC/AT/PE model telescope from a car. The cord is an ample 25 feet long ... Learn More
Model#: 07043
Meade - 20mm Series 5000 Ultra Wide Angle 82° Waterproof Eyepiece - 2"
Meade Series 5000 Ultra Wide Angle 20mm Eyepiece (2") #07743. Meade Series 5000 Ultra Wide Angle eyepieces offer revolutionary new advances in resolution... Learn MoreModel#: 07743
Meade - #829 ViewfinderMeade #829 Rear-Focus Viewfinder #07829. Easily locate and center deep sky objects with this straight-through Meade Model #828 8x50 Rear-Focus Viewfinder. Includes mounting bracket for Meade LX90 and LX200 models ... Learn More
Model#: 07829_meade
Meade - 12" ACF Advanced Coma-Free (f/8) Optical Tube Assembly - (UHTC)
The Meade Instruments 12" f/8 ACF Optical Tube Assembly (OTA) features a 12" aperture, f/8 optical system with Meade's Advanced Coma Free (ACF) optics and high-contrast baffling that ensures crisp, pinpoint imaging to the very edge of the field.... Learn MoreFREE SHIPPINGModel#: 1208-80-00(48 States)
Meade - Dovetail Plate for 10 " OTA includes 2 radius blocks and mounting hardwareMeade Dovetail Plate for 10" Schmidt-Cassegrain and Advanced Coma-Free telescopes. Part of the Series 5000 Auxiliary Equipment System. Equip your Meade LX90, LX200, or other SCT or ACF telescope with the best and maximize its performance today ... Learn More
Model#: 07922
Meade - LX200 Control Panel Assembly (16" models)Compatibility: LX200 16" models. ... Learn More
FREE SHIPPINGModel#: 37-7255-16LF(48 States)
Founded in 1972 and public since 1997, Meade is a world leader in the design and manufacture of telescopes and accessories for amateur astronomers. The Company's innovative and technologically advanced products are recognized to be among the best in the world.


text:
A Clown And His Pipe Lyrics - Hands Like Houses
There's better ways for us to waste our days,
Than returning stares that we borrowed for too long.
For too long, swallowed up by an empty page.
What starvation feeds you, devourer
Of the words of a thousand authors and poets, alike?
Wells have emptied to whet your thirst,
So I'll shake out to the last, a drop of fluency
To carve ink into these precious words,
To dedicate a thought in desperation.
We could light a fire and forge a silver tongue.
Drawn beneath our blunt remarks,
Fashioned from all of our meaningless change.
What would it take, to pry these ragged teeth, to tear these jaws apart?
What would it prove, to wrench them from my heels, to shed them from my heart?
Swallowing swords, sharpened by turning cheeks between blows.
I feel this is better left a performers art.
It's a narrow throat that keeps a razor's edge from the heart.
I'd rather not speak in tongues.
But I'll take every breath - I'll make every breath a piper, charming flames,
Singing and dancing, out from their smouldering bed.
Swallow the pen, devour the sword.
Inhale the proverbs whole.
Spinning on static, gouged before the peak.
In this chaos of frequencies it's so hard to speak.
This noise is nameless,
Stumbling like a beggar,
Desperate for some kind of change.
Click here to submit the Corrections of A Clown And His Pipe Lyrics
Please Click Here to Print A Clown And His Pipe Lyrics
The following area is only for review, if you want to submit the lyrics or the corrections of the lyrics, please click the link at the end of A Clown And His Pipe Lyrics.


text:
Vince McMahon is a big fan of reality television shows, and he wants that on the new WWE Network. Many are speculating that Tough Enough could be one of the first shows added, especially after Bill DeMott posted a teaser message on his Twitter account.
Mike Bennett made his official debut for ROH at Proving Ground, an event held in Boston. He worked a match against Daniel Puder, the former Tough Enough competitor and WWE star, and lost. Bennett is considered a young guy who should be with the company for the next several years.
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text:
1_News|1_Press_Release|School_of_Medicine|Medical_Center|SLUCare|ResearchSLU, St. Louis University, Saint Louis University, Di Cera, Enrico Di Cera, thrombin, thrombosis, blood clottingUniversitytrue20100621T13:00:00 Carrie firstname.lastname@example.com Saint Louis University Investigators Perfect New Version of Blood-Regulator ThrombinResearch Harnesses Enzyme's Anti-Blood Clotting Abilities New research harnesses an enzyme's anti-blood clotting abilities.
ST. LOUIS - In research led by a Saint Louis University investigator, molecular biologists have discovered a way to harness the enzyme thrombin's anti-blood clotting properties. The finding opens the door to new medications that will treat diseases related to thrombosis, the presence of blood clots in blood vessels, which is responsible for nearly a third of all deaths in the U.S.

Enrico Di Cera, M.D.

"Thrombosis is one of the most prevalent causes of fatal disease," said lead researcher Enrico Di Cera, M.D., chair of the department of biochemistry and molecular biology at Saint Louis University School of Medicine. "If we could develop an anti-thrombotic drug that didn't carry a risk of hemorrhage, it would revolutionize the treatment of cardiovascular disease, the leading cause of death in the U.S. and Western world.

"This research carries us closer to that goal."

Blood clotting has long ensured our survival, stopping blood loss after an injury. On the other hand, if triggered in the wrong conditions, clotting can lead to debilitating or fatal conditions like heart attack, stroke and deep vein thrombosis.

Funded by the National Institutes of Health, and published in the June 18, 2010 edition of The Journal of Biological Chemistry (Vol. 285. No. 25), researchers zeroed in on thrombin, a vitamin K-dependent enzyme key to blood coagulation.

An unusual enzyme, thrombin performs distinct and even opposing functions, acting as a pro-coagulant, pro-thrombotic but also as an anti-coagulant factor depending on which target protein - fibrinogen, PAR1 or protein C - becomes activated in the blood. Researchers studied thrombin to decipher the structure-function code that enables this protein to do so many different things.

Tackling this problem far below the level of tissue and organs, molecular biologists looked deep inside the structure, examining thrombin's amino acids to note how they behave and interact with each other.

Using protein engineering, researchers produced mutations in the enzyme's amino acid sequence, carefully taking out pieces and replacing them, a few at a time, to find the exact locations that influence the function of thrombin. Once they found these "hot spots," researchers went even further - trying each of the 20 natural amino acids to see which mutation would allow them to turn on and off the pro-coagulant, pro-thrombotic and anti-coagulant functions.

"We asked the question, what if we can take this enzyme and dissociate the functions, allowing only the function we want?" said Di Cera.

In earlier research, Di Cera's team did just that. They engineered thrombin to promote activity toward protein C - the anticoagulant target protein - and minimize activity toward fibrinogen and PAR1 - the procoagulant and prothrombotic targets.

"In 2000, we engineered a thrombin mutant with potent anticoagulant properties both in vitro and in vivo and we are moving this mutant to a phase I trial," said Di Cera. "In this study, however, we pressed further. We wanted to optimize this mutant to completely abrogate activity toward fibrinogen and PAR1.

"With this research we optimized the mutant so that there is no clotting at all. Furthermore, we generated a new mutant with exclusive prothrombotic activity, thereby demonstrating that the individual functions of thrombin can be dissociated by replacing a single amino acid in the protein."

Once clinical trials are performed, researchers hope to have developed an alternative to heparin, a blood thinner that is used to prevent blood clots and is often used before surgery, but which also causes allergic reactions, dosage challenges and bleeding.

"Heparin is a brute-force remedy that shuts down all thrombin functions, including its beneficial anti-coagulant role," said Di Cera. "Our approach is a new strategy that like a smart bomb only targets the functions we want to turn off."

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: cancer, liver disease, heart/lung disease, aging and brain disease, and infectious disease.
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