text:
[Bumped For Very Obvious Reasons] 8.5 Things I Rejoice In This Post-Election Day
5) This isn't the Episcopal Church. Our country is far juster, far more interested in the rule of law, far more stable, far more popular, far less vicious, and far more conservative. It is completely within our power as conservatives—with God's help—to transform this country's political landscape if we so choose. It will be very hard and very long. The next two years will be appallingly painful. Every week or month, we'll be reminded of the judgement of God—and our challenge will be not to get angry, or despairing, or inactive, but rather to humble ourselves all over again, repent, acknowledge the horrible consequences of our compromises, corruption, passivity, and loss of principle, and continue turning away from the wrong path and seeking the right one.
Restarting the Game: Archbishop Welby Attempts To Hit The Reset Button
It's not a question of "how will the Communion divide"—that division, albeit internal, has already occurred. The further question is not "how can we all live together in the midst of our profound disagreements" but is rather "what is to be done with the Provinces which have engaged in intrinsically communion-dividing actions?"
Got Ice Water?
The idea that we shouldn't be able to indulge in something silly like the ice-water challenge because millions of African children are dying of thirst, says nothing about the wastefulness of Americans, and everything about the utter inability of Africa to take care of itself.
The utilitarian unity of burning at the stake and abortion
The Church thought it was sparing heretics eternal torment by burning them at the stake. Abortionists tell us they are sparing people from miserable earthly lives. Both ways, "It's for their own good."
Truro Rebirth Credited to Relationship Between the Rev. Baucum and Bishop Johnston
After more than ten years on the front lines of the Anglican wars, I have made a major change. This past Easter vigil, my family and I were confirmed in the Roman Catholic Church.
Is the Creed "the" Sufficient Standard of Orthodoxy?
The Creeds themselves, then, require obedience to Jesus Christ as the One Lord over all things. To profess the Creed but reject the word of God as revealed in the scriptures regarding marriage and sexuality is incoherent.
Stand Firm is 10 Years Old Today
In true Tom Sawyer fence-whitewashing style, I have minions who keep the site humming, while I sit in the shade chewing a blade of grass and complimenting them on their fine efforts.
Three Excuses for Bishop Salmon's Inexcusable Invitation
Can you imagine what Paul might say to this kind of hair splitting? The Galatians respond to Paul's letter: "Dear Paul, you wrote that the Judaizers are accursed and eternally condemned and that we ought not to listen to them because they teach a gospel that damns…but how about we let them preach to our pastors in training?
60 Theses on Real Integrity in the Anglican Church
The refusal to affirm a truth (particularly when it is a truth about God) is often just another way of denying it, but without taking responsibility for your denial. This is therefore a double dishonesty which only compounds the deceit.
"How am I gonna be an optimist about this?"
A modern city provides the visual for words evoking the historic catastrophe. It can happen again, and that isn't just a function of natural cycles. There are moral and even supernatural forces in play. There's always a sense that Pompeii had it coming. It's like Sodom and Gomorrah for folks who don't want to admit to that Old Testament God stuff.
A Declaration of Principles for Reconciliation
There are only two words to be spoken to false teachers: "repent" and "recant" along with the assurance that forgiveness and warm welcome await those who heed the call. We will not take part in the indaba process which results only in providing false teachings and false teachers with equal footing and equal voice alongside the teachings of Christ through his apostles
BREAKING: Welby names Tory Baucum as "Canterbury Preacher"
At Stand Firm we suspect there may be some who will question Tory's "commitment to the present day reformation" given his willingness to affirm Johnston's ministry. It will be viewed by them as a compromised commitment.
Walking and Talking
Let it be a small reminder of how hostile the world is to the Gospel, and a small reminder of what you've signed up for when you agreed to take up your cross. The world - in this case represented by gay activists and the media who kowtow to them - hates you. They hate your family, they hate your values, and they especially hate this Jesus.
Night Thoughts Away from Home during Christmas Season
I share readily in the town's festive mood, smiling at perfect strangers and wishing them all "Merry Christmas." What is it about Christmas that brings out the best in friends and strangers alike?
Grafton Appointment Exposes Massive Differences in the Anglican Church in Australia
Questioning Charismaticism
If Charismaticism is true, God speaks through tongues, words of knowledge, and prophecy, to guide the church but does not give the church an objective measure for determining whether in fact he is speaking.
The Week
Encouraging Thoughts from an NFL Player
1 Ben Watson is a tight end for the New Orleans Saints. Breitbart picked up his facebook post on the Ferguson issue. It's well worth the…
A Thanksgiving to God, for His House
1 Lord, Thou hast given me a cell Wherein to dwell, A little house, whose humble roof Is weather-proof: Under the spars of which I lie …
Atlanta Punishes Fire Chief for Expressing HIs Religious Views
12 Atlanta's fire chief is under heavy attack for expressing his religious beliefs.Atlanta Fire Chief Kelvin Cochran has been suspended without pay for one month because of authoring a religious book…
yesHEis – sharing Jesus online
I'm always looking for useful and effective ways to share Jesus with others so it was a real delight for me yesterday to be introduced to yesHEis. Here's how it works.
ECUSA Denied Leave to Appeal in Quincy Case
13 Today the Illinois Supreme Court posted twenty-eight pages of its recent dispositions of requests made by losing parties for leave to appeal their decision to that Court. On page twelve, at the very…
The Whole Duty of Man
6 Ecclesiastes 12:13 is one of my favorite verses.The end of the matter; all has been heard. Fear God and keep his commandments, for this is the whole duty of man.It cuts to the chase and…
Ephraim Radner on Why I Changed My Mind on Civil Marriage
9 From First Things, where there is more: The following question was forced upon me: What, in fact, is the character of the "marriages" recognized by our society more broadly? Is…
The Supplication
3 No indictment in Ferguson, MO. Social media on emotional overload. Plus all the other "stuff" indicative of widening chaos and descending darkness. This is from the Book of Common Prayer (ECUSA, 1979), p. 152:…
Abandoning the Search for the Gay Gene and Embracing Choice
6 Interesting article over at the Daily BeastAnd as homosexuality approaches a critical mass of cultural acceptance, more and more people are comfortable challenging the dominant "born that way" narrative. In 2012, Sex…
ACNA Primate: Don't sign marriage pledge for now
42 An email circulating. Received via an ACNA friend. Grace and peace to you in the Name of Christ Jesus our Lord!!! I hope this email finds you well and walking in the fullness of the…
UK "journalists" distort study to advocate for LGBT church
6 Right of the top, the headline stands the study on its head: Poll: Children now describe someone who is religious as dangerous or threatening Yes, 1 in 8…
More than 150 Clergy Sign The Marriage Pledge in 48 Hours
8 Surely your rector needs to prayerfully consider it—you can pass on a link to the pledge here. I think Christian clergy are hungry to clearly and publicly differentiate from the faux state redefinition…
Oh Dear—Jim Naughton is peevish again—so give generously to the IRD
11 You can always tell his level of outrage—and the effort to obscure it—by the sidetracking and the red herrings and the straw men. Fun to skim . . . My favorite part of the…
One Black Episcopalian on Ferguson
7 I have a Black friend of several decades. We met in church. He lives in St. Louis. Here's his perspective on the current dynamics in Ferguson - I didn't solicit this and I don't claim…
The Marriage Pledge and the Libertarian Solution to the Marriage Debate
19 Okay—so right on time Mere Orthodoxy posts an analysis of The Marriage Pledge and argues that this is a "surrender" to the culture. You may recall that I'd…
Recent Comments
SC blu cat lady - ECUSA Denied Leave to Appeal in Quincy Case
Mr. Haley, Now that Illinois court ruling is final, how likely is it that Judge Goodstein will learn of the Illinois court decision. And if she does, could it play a part in her judgement?…
helpmelord - Encouraging Thoughts from an NFL Player
Absolutely wonderful!
Katherine - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
I once worked with a man who distributed Mormon literature at work. Someone complained, and he was asked to stop. End of problem. If the fire chief was actively discriminating against any employees because of…
Br. Michael - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
Actually it is perfectly clear that homosexual sex is a perversion and the the Chief was not incorrect in saying so. It is also clear that the homosexuals have the power to intimidate and silence…
tjmcmahon - ECUSA Denied Leave to Appeal in Quincy Case
I definitely am NOT an attorney, but a question I would have along this line is whether the corporate status of the various dioceses makes any difference? San Joaquin, for example, is a corporation sole,…
Words Matter - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
#7 I also missed the part about him distributing the book on the job. That part of the picture changes things from a first amendment issue to employment law. The article says he was suspended…
Charles - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
Jackie #7, I should have been more clear: I would "hope" that the response would be the same if it were a Muslin manager passing out discriminatory materials to fellow public servants.
Cranmerian - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
"I want to be clear that the material in Chief Cochran's book is not representative of my personal beliefs, and is inconsistent with the administration's work to make Atlanta a more welcoming city for all…
A. S. Haley - ECUSA Denied Leave to Appeal in Quincy Case
As a follow-up to my previous comment, I would like closely to examine the question of whether or not the Illinois appellate decision, that has now become final, is res judicata against ECUSA on the…
A. S. Haley - ECUSA Denied Leave to Appeal in Quincy Case
SC bcl (#9) - yes, the decision should have considerable significance in South Carolina. The right to "the name and the trademarks of the diocese" will belong to Bishop Lawrence's Diocese if the court finds…
Jackie - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
I did not think it was clear that he was the distributor of the book although that is certainly a possibility. I thought the punishment prior to an investigation was outrageous. Charles. If you seriously…
SC blu cat lady - ECUSA Denied Leave to Appeal in Quincy Case
Mr. Haley, Very great result for the Anglican diocese of Quincy! As the case in SC is very different in that it only asks who has the right to the name and the trademarks of…
Undergroundpewster - ECUSA Denied Leave to Appeal in Quincy Case
The Beers/Schori opening gambit ain't working out so well at the end of the match.
Undergroundpewster - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
He was "...distributing copies of the book on city property after a number of firefighters said they received them in the workplace."bl;es And I suspect this will be the city's justification for the suspension if…
Words Matter - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
#3 - Public employees are not public property. Because governmental entities are involved, the first amendment is also in play. Unless he wrote his book on city time or used city resources, it's open and…
Charles - Atlanta Punishes Fire Chief for Expressing HIs Religious Views
If a Muslim employee did the same thing he did, I would expect the same response.


text:
Added Mar 11, 2013
by Slotaby
Austin, Texas, U...
Overall a pretty easy project and a cute, basic shirt – I'm planning on making more in different colors. I had some trouble with my machine wanting to eat my fabric at the hems and collar… I think I need a walking foot. The sleeve hems turned out ok, the collar I just folded over and zigzag stitched, and I didn't hem the bottom at all. The shirt was a little too long so I cut the bottom off and it made a cute circle scarf for my cat, which I'm sure he appreciated :)
Mar 12, 2013, 03.37 AMby lovefromsf
So cute!
Mar 11, 2013, 10.43 PMby freaky-philomeen
looks great! the color is cool!
and your cat looks….well, it looks me deep in the eyes and wants to jump out of the screen or something ;)) I also had a completely black cat but of course not with a scarf.
Mar 11, 2013, 07.45 PMby asperge11
Simple but super cute :) I love the colour!
Mar 11, 2013, 05.34 PMby Mary Athey
ITS lovely, well done x
Add to Favorites 8 people added it
Sewing & Techniques
See how Meg made this edgy dress using the Janome Artistic Edge Digital Cutter!
Editors' Pick
No need to go outside… spend the morning in dolled up in this collection of vintage style pajamas.
BurdaStyle Magazine US
Get an inside look at the patterns from the first 4 issues of BurdaStyle US
As an early special Black Friday promotion you can now enroll in the course ($80 value) for $49.99!
Register for Meg's new course, space is limited!
Sewing & Techniques
Learn how to use your bodice sloper to draft this popular collar style
Get the Piped Trench Coat pattern
You must allow our "request for permission" request to login to Burdastyle with Facebook.

subset: commoncrawl


text:
Are you Karl J L Fernandes?Claim your profile
Publications (25)152.68 Total impact
Article: Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis.[Show abstract] [Hide abstract]
ABSTRACT: Environmental enrichment (EE) exerts powerful effects on brain physiology, and is widely used as an experimental and therapeutic tool. Typical EE paradigms are multifactorial, incorporating elements of physical exercise, environmental complexity, social interactions and stress, however the specific contributions of these variables have not been separable using conventional housing paradigms. Here, we evaluated the impacts of these individual variables on adult hippocampal neurogenesis by using a novel "Alternating EE" paradigm. For 4 weeks, adult male CD1 mice were alternated daily between two enriched environments; by comparing groups that differed in one of their two environments, the individual and combinatorial effects of EE variables could be resolved. The Alternating EE paradigm revealed that (1) voluntary running for 3 days/week was sufficient to increase both mitotic and post-mitotic stages of hippocampal neurogenesis, confirming the central importance of exercise; (2) a complex environment (comprised of both social interactions and rotated inanimate objects) had no effect on neurogenesis itself, but enhanced depolarization-induced c-Fos expression (attributable to social interactions) and buffered stress-induced plasma corticosterone levels (attributable to inanimate objects); and (3) neither social isolation, group housing, nor chronically increased levels of plasma corticosterone had a prolonged impact on neurogenesis. Mouse strain, handling and type of running apparatus were tested and excluded as potential confounding factors. These findings provide valuable insights into the relative effects of key EE variables on adult neurogenesis, and this "Alternating EE" paradigm represents a useful tool for exploring the contributions of individual EE variables to mechanisms of neural plasticity.PLoS ONE 01/2014; 9(1):e86237. · 3.53 Impact Factor
Article: Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions.[Show abstract] [Hide abstract]
ABSTRACT: The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that ependymal cells lining the central canal possess latent neural stem cell potential, undergoing proliferation and multi-lineage differentiation following experimental SCI. To determine whether reactive ependymal cells are a realistic endogenous cell population to target in order to promote spinal cord repair, we assessed the spatiotemporal dynamics of ependymal cell proliferation for up to 35 days in three models of spinal pathologies: contusion SCI using the Infinite Horizon impactor, focal demyelination by intraspinal injection of lysophosphatidylcholine (LPC), and autoimmune-mediated multi-focal demyelination using the active experimental autoimmune encephalomyelitis (EAE) model of MS. Contusion SCI at the T9-10 thoracic level stimulated a robust, long-lasting and long-distance wave of ependymal proliferation that peaked at 3 days in the lesion segment, 14 days in the rostral segment, and was still detectable at the cervical level, where it peaked at 21 days. This proliferative wave was suppressed distal to the contusion. Unlike SCI, neither chemical- nor autoimmune-mediated demyelination triggered ependymal cell proliferation at any time point, despite the occurrence of demyelination (LPC and EAE), remyelination (LPC) and significant locomotor defects (EAE). Thus, traumatic SCI induces widespread and enduring activation of reactive ependymal cells, identifying them as a robust cell population to target for therapeutic manipulation after contusion; conversely, neither demyelination, remyelination nor autoimmunity appears sufficient to trigger proliferation of quiescent ependymal cells in models of MS-like demyelinating diseases.PLoS ONE 01/2014; 9(1):e85916. · 3.53 Impact Factor
Article: Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here.[Show abstract] [Hide abstract]
ABSTRACT: In the brains of adult vertebrates, including humans, neurogenesis occurs in restricted niches where it maintains cellular turnover and cognitive plasticity. In virtually all species, however, aging is associated with a significant decline in adult neurogenesis. Moreover, an acceleration of neurogenic defects is observed in models of Alzheimer's disease and other neurodegenerative diseases, suggesting an involvement in aging- and disease-associated cognitive deficits. To gain insights into when, how and why adult neurogenesis decreases in the aging brain, we critically reviewed the scientific literature on aging of the rodent subventricular zone, the neurogenic niche of the adult forebrain. Our analysis revealed that deficits in the neurogenic pathway are largely established by middle age, but that there remains striking ambiguity in the underlying mechanisms, especially at the level of stem and progenitor cells. We identify and discuss several challenging issues that have contributed to these key gaps in our current knowledge. In the future, addressing these issues should help untangle the interactions between neurogenesis, aging and aging-associated diseases.European Journal of Neuroscience 06/2013; 37(12):1978-86. · 3.75 Impact Factor
Article: Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain.[Show abstract] [Hide abstract]
ABSTRACT: Adult forebrain neurogenesis is dynamically regulated. Multiple families of niche-derived cues have been implicated in this regulation, but the precise roles of key intracellular signaling pathways remain vaguely defined. Here, we show that mammalian target of rapamycin (mTOR) signaling is pivotal in determining proliferation versus quiescence in the adult forebrain neural stem cell (NSC) niche. Within this niche, mTOR complex-1 (mTORC1) activation displays stage specificity, occurring in transiently amplifying (TA) progenitor cells but not in GFAP+ stem cells. Inhibiting mTORC1 depletes the TA progenitor pool in vivo and suppresses epidermal growth factor (EGF)-induced proliferation within neurosphere cultures. Interestingly, mTORC1 inhibition induces a quiescence-like phenotype that is reversible. Likewise, mTORC1 activity and progenitor proliferation decline within the quiescent NSC niche of the aging brain, while EGF administration reactivates the quiescent niche in an mTORC1-dependent manner. These findings establish fundamental links between mTOR signaling, proliferation, and aging-associated quiescence in the adult forebrain NSC niche.Journal of Neuroscience 10/2012; 32(43):15012-26. · 6.91 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Neuroblastoma (NB) is the most common and lethal extracranial solid tumor of childhood. Despite aggressive therapy, more than half of the children with advanced NB will die of uncontrolled metastatic disease. After chemotherapy, tumor-initiating cells (TICs) could persist, cause relapses and metastasis. The aim of this study is to demonstrate the tumor-initiating properties of CD133high NB cells and to identify new specific genetic abnormalities. Isolation of the CD133high cell population from NB cell lines was followed by neurosphere formation, soft agar assays, and orthotopic injections in NOD/SCID/IL2Rγc-null mice. A differential genotyping analysis was performed with Affymetrix SNP 6.0 arrays on CD133low and CD133high populations and the frequency of the abnormalities of 36 NB tumors was determined. Our results show that CD133high NB cells possess tumor-initiating properties, as CD133high cells formed significantly more neurospheres and produced significantly more colonies in soft agar than CD133low. Injection of 500 CD133high cells was sufficient to generate primary tumors and frequent metastases in mice. Differential genotyping analysis demonstrated two common regions with gains (16p13.3 and 19p13.3) including the gene EFNA2 in the CD133high population, and two with loss of heterozygosity (16q12.1 and 21q21.3) in the CD133low population. The gain of EFNA2 correlated with increased expression of the corresponding protein. These abnormalities were found in NB samples and some were significantly correlated with CD133 expression. Our results show that CD133high NB cells have TICs properties and present different genotyping characteristics compared to CD133low cells. Our findings reveal insights into new therapeutic targets in NB TICs.Genes Chromosomes and Cancer 04/2012; 51(8):792-804. · 3.55 Impact Factor
Article: Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment.[Show abstract] [Hide abstract]
ABSTRACT: Hippocampal neurogenesis continues into adulthood in mammalian vertebrates, and in experimental rodent models it is powerfully stimulated by exposure to a voluntary running wheel. In this study, we demonstrate that exposure to a running wheel environment, in the absence of running, is sufficient to regulate specific aspects of hippocampal neurogenesis. Adult mice were provided with standard housing, housing enriched with a running wheel or housing enriched with a locked wheel (i.e., an environment comparable to that of running animals, without the possibility of engaging in running). We found that mice in the running wheel and locked wheel groups exhibited equivalent increases in proliferation within the neurogenic niche of the dentate gyrus; this included comparable increases in the proliferation of radial glia-like stem cells and the number of proliferating neuroblasts. However, only running animals displayed increased numbers of postmitotic neuroblasts and mature neurons. These results demonstrate that the running wheel environment itself is sufficient for promoting proliferation of early lineage hippocampal precursors, while running per se enables newly generated neuroblasts to survive and mature into functional hippocampal neurons. Thus, both running-independent and running-dependent stimuli are integral to running wheel-induced hippocampal neurogenesis.Hippocampus 12/2011; 21(12):1334-47. · 5.49 Impact Factor
Article: Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood.[Show abstract] [Hide abstract]
ABSTRACT: Stem cells can exist in either active or quiescent states. In the aging hippocampus, adult neural stem cells (aNSCs) shift into a quiescent state, contributing to age-related reductions in hippocampal neurogenesis. Here, we focused on the subventricular zone (SVZ) stem cell niche of the adult forebrain, asking to what extent quiescence-associated changes in aNSCs are initiated between early and middle-age. Immunohistochemical and label retention experiments revealed that the overall output of the SVZ stem cell system was already highly decreased in middle-aged mice (12-months-old) compared with young adult mice (2-month-old), as measured by reduced marker expression for multiple neural precursor sub-populations and diminished addition of SVZ-derived neuroblasts to the olfactory bulbs (OBs). These changes were associated with significant cytological aberrations within the SVZ niche, including an overall atrophy of the SVZ and accumulation of large lipid droplets within ependymal cells, which are key support cells of the SVZ niche. Importantly, the reduced output of the middle-aged SVZ stem cell system correlated with quiescence-associated changes in middle-aged aNSCs. Specifically, while tissue culture experiments showed that young adult and middle-aged forebrains possessed equal numbers of neurosphere-forming aNSCs, the middle-aged neurospheres exhibited differences in their in vitro properties, and middle-aged aNSCs in vivo divided less frequently. These findings demonstrate that aNSCs begin undergoing quiescence-associated changes between early and mid-adulthood in the mouse SVZ, and serve as a useful framework for further studies aimed at defining the early events involved in aging-associated quiescence of aNSCs.Neuroscience 01/2011; 173:135-49. · 3.12 Impact Factor
Article: Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.[Show abstract] [Hide abstract]
ABSTRACT: Alzheimer's disease (AD) affects cognitive modalities that are known to be regulated by adult neurogenesis, such as hippocampal- and olfactory-dependent learning and memory. However, the relationship between AD-associated pathologies and alterations in adult neurogenesis has remained contentious. In the present study, we performed a detailed investigation of adult neurogenesis in the triple transgenic (3xTg) mouse model of AD, a unique model that generates both amyloid plaques and neurofibrillary tangles, the hallmark pathologies of AD. In both neurogenic niches of the brain, the hippocampal dentate gyrus and forebrain subventricular zone, we found that 3xTg mice had decreased numbers of (i) proliferating cells, (ii) early lineage neural progenitors, and (iii) neuroblasts at middle age (11months old) and old age (18months old). These decreases correlated with major reductions in the addition of new neurons to the respective target areas, the dentate granule cell layer and olfactory bulb. Within the subventricular zone niche, cytological alterations were observed that included a selective loss of subependymal cells and the development of large lipid droplets within the ependyma of 3xTg mice, indicative of metabolic changes. Temporally, there was a marked acceleration of age-related decreases in 3xTg mice, which affected multiple stages of neurogenesis and was clearly apparent prior to the development of amyloid plaques or neurofibrillary tangles. Our findings indicate that AD-associated mutations suppress neurogenesis early during disease development. This suggests that deficits in adult neurogenesis may mediate premature cognitive decline in AD.European Journal of Neuroscience 09/2010; 32(6):905-20. · 3.75 Impact Factor
Article: Acceleration of aging-dependent changes in adult neural stem cell populations in the 3XTg mouse model of Alzheimer's diseaseAlzheimers & Dementia - ALZHEIMERS DEMENT. 01/2010; 6(4).
Article: Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells in the adult mammalian spinal cord.[Show abstract] [Hide abstract]
ABSTRACT: A stem cell's microenvironment, or "niche," is a critical regulator of its behaviour. In the adult mammalian spinal cord, central canal ependymal cells possess latent neural stem cell properties, but the ependymal cell niche has not yet been described. Here, we identify important similarities and differences between the central canal ependymal zone and the forebrain subventricular zone (SVZ), a well-characterized niche of neural stem cells. First, direct immunohistochemical comparison of the spinal cord ependymal zone and the forebrain SVZ revealed distinct patterns of neural precursor marker expression. In particular, ependymal cells in the spinal cord were found to be bordered by a previously uncharacterized sub-ependymal layer, which is relatively less elaborate than that of the SVZ and comprised of small numbers of astrocytes, oligodendrocyte progenitors and neurons. Cell proliferation surrounding the central canal occurs in close association with blood vessels, but unlike in the SVZ, involves mainly ependymal rather than sub-ependymal cells. These proliferating ependymal cells typically self-renew rather than produce transit-amplifying progenitors, as they generate doublets of progeny that remain within the ependymal layer and show no evidence of a lineage relationship to sub-ependymal cells. Interestingly, the dorsal pole of the central canal was found to possess a sub-population of tanycyte-like cells that express markers of both ependymal cells and neural precursors, and their presence correlates with higher numbers of dorsally proliferating ependymal cells. Together, these data identify key features of the spinal cord ependymal cell niche, and suggest that dorsal ependymal cells possess the potential for stem cell activity. This work provides a foundation for future studies aimed at understanding ependymal cell regulation under normal and pathological conditions.Neuroscience 09/2009; 164(3):1044-56. · 3.12 Impact Factor
Article: Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice.[Show abstract] [Hide abstract]
ABSTRACT: Voluntary wheel-running induces a rapid increase in proliferation and neurogenesis by neural precursors present in the adult rodent hippocampus. In contrast, the responses of hippocampal and other central nervous system neural precursors following longer periods of voluntary physical activity are unclear and are an issue of potential relevance to physical rehabilitation programs. We investigated the effects of a prolonged, 6-week voluntary wheel-running paradigm on neural precursors of the CD1 mouse hippocampus and forebrain. Examination of the hippocampus following 6 weeks of running revealed two to three times as many newly born neurons and 60% more proliferating cells when compared with standard-housed control mice. Among running mice, the number of newly born neurons correlated with the total running distance. To establish the effects of wheel-running on hippocampal precursors dividing during later stages of the prolonged running regime, BrdU was administered after 3 weeks of running and the BrdU-retaining cells were analyzed 18 days later. Quantifications revealed that the effects of wheel-running were maintained in late-stage proliferating cells, as running mice had two to three times as many BrdU-retaining cells within the hippocampal dentate gyrus, and these yielded greater proportions of both mature neurons and proliferative cells. The effects of prolonged wheel-running were also detected beyond the hippocampus. Unlike short-term wheel-running, prolonged wheel-running was associated with higher numbers of proliferating cells within the ventral forebrain subventricular region, a site of age-associated decreases in neural precursor proliferation and neurogenesis. Collectively, these findings indicate that (i) prolonged voluntary wheel-running maintains an increased level of hippocampal neurogenesis whose magnitude is linked to total running performance, and (ii) that it influences multiple neural precursor populations of the adult mouse brain.Hippocampus 05/2009; 19(10):913-27. · 5.49 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The isolation and experimental manipulation of multipotent precursors is of increasing therapeutic relevance. We recently reported the generation of cultures of Skin-derived Precursors ('SKPs'), multipotent cells that can be isolated from the dermis of embryonic, neonatal, and adult rodent skin (1), and from adult human skin (2) SKPs have similarities to stem cells of the embryonic neural crest (3), and differentiate into a variety of neural and mesodermal cell phenotypes, including peripheral neurons and glial cells, smooth muscle cells, bone, cartilage, and adipocytes (3-5). Here, we detail the establishment, propagation, neural differentiation, and immunocytochemical analysis of SKP cultures.Methods in molecular biology (Clifton, N.J.) 02/2009; 482:159-70. · 1.29 Impact Factor
Article: The rat heart contains a neural stem cell population; role in sympathetic sprouting and angiogenesis.[Show abstract] [Hide abstract]
ABSTRACT: Nestin-expressing cells were identified in the normal rat heart characterized by a small cell body and numerous processes and following an ischemic insult migrated to the infarct region. The present study was undertaken to identify the phenotype, origin and biological role of nestin-expressing cells during reparative fibrosis. A neural stem cell phenotype was identified based on musashi-1 expression, growth as a neurosphere, and differentiation to a neuronal cell. Using the Wnt1-cre; Z/EG transgenic mouse model, which expresses EGFP in embryologically-derived neural crest cells, the reporter signal was detected in nestin-expressing cells residing in the heart. In infarcted human hearts, nestin-expressing cells were detected in the viable myocardium and the scar and morphologically analogous to the population identified in the rat heart. Following either an ischemic insult or the acute administration of 6-hydroxydopamine, sympathetic sprouting was dependent on the physical association of neurofilament-M immunoreactive fibres with nestin-positive processes emanating from neural stem cells. To specifically study the biological role of the subpopulation in the infarct region, neural stem cells were isolated from the scar, fluorescently labelled and transplanted in the heart of 3-day post-MI rats. Injected scar-derived neural stem cells migrated to the infarct region and were used as a substrate for de novo blood vessel formation. These data have demonstrated that the heart contains a resident population of neural stem cells derived from the neural crest and participate in reparative fibrosis. Their manipulation could provide an alternative approach to ameliorate the healing process following ischemic injury.Journal of Molecular and Cellular Cardiology 08/2008; 45(5):694-702. · 5.15 Impact Factor
Article: Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential.[Show abstract] [Hide abstract]
ABSTRACT: We previously made the surprising finding that cultures of multipotent precursors can be grown from the dermis of neonatal and adult mammalian skin. These skin-derived precursors (SKPs) display multi-lineage differentiation potential, producing both neural and mesodermal progeny in vitro, and are an apparently novel precursor cell type that is distinct from other known precursors within the skin. In this review, we begin by placing these findings within the context of the rapidly evolving stem cell field. We then describe our recent efforts focused on understanding the developmental biology of SKPs, discussing the idea that SKPs are neural crest-related precursors that (i) migrate into the skin during embryogenesis, (ii) persist within a specific dermal niche, and (iii) play a key role in the normal physiology, and potentially pathology, of the skin. We conclude by highlighting some of the therapeutic implications and unresolved questions raised by these studies.Philosophical Transactions of The Royal Society B Biological Sciences 02/2008; 363(1489):185-98. · 6.23 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Multipotent precursors similar to stem cells of the embryonic neural crest (NC) have been identified in several postnatal tissues, and are potentially useful for research and therapeutic purposes. However, their neurogenic potential, including their ability to produce electrophysiologically active neurons, is largely unexplored. We investigated this issue with regard to skin-derived precursors (SKPs), multipotent NC-related precursors isolated from the dermis of skin. SKP cultures follow an appropriate pattern and time-course of neuronal differentiation, with proliferating nestin-expressing SKPs generating post-mitotic neuronal cells that co-express pan-neuronal and peripheral autonomic lineage markers. These SKP-derived neuron-like cells survive and maintain their peripheral phenotype for at least 5 weeks when transplanted into the CNS environment of normal or kainate-injured hippocampal slices. Undifferentiated SKPs retain key neural precursor properties after multi-passage expansion, including growth factor dependence, nestin expression, neurogenic potential, and responsiveness to embryonic neural crest fate determinants. Despite undergoing an apparently appropriate neurogenic process, however, SKP-derived neuron-like cells possess an immature electrophysiological profile. These findings indicate that SKPs retain latent neurogenic properties after residing in a non-neural tissue, but that additional measures will be necessary to promote their differentiation into electrophysiologically active neurons.Experimental Neurology 10/2006; 201(1):32-48. · 4.65 Impact Factor
Article: Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.[Show abstract] [Hide abstract]
ABSTRACT: Precursor cells of the embryonic cortex sequentially generate neurons and then glial cells, but the mechanisms regulating this neurogenic-to-gliogenic transition are unclear. Using cortical precursor cultures, which temporally mimic this in vivo differentiation pattern, we demonstrate that cortical neurons synthesize and secrete the neurotrophic cytokine cardiotrophin-1, which activates the gp130-JAK-STAT pathway and is essential for the timed genesis of astrocytes in vitro. Our data indicate that a similar phenomenon also occurs in vivo. In utero electroporation of neurotrophic cytokines in the environment of embryonic cortical precursors causes premature gliogenesis, while acute perturbation of gp130 in cortical precursors delays the normal timed appearance of astrocytes. Moreover, the neonatal cardiotrophin-1-/- cortex contains fewer astrocytes. Together, these results describe a neural feedback mechanism; newly born neurons produce cardiotrophin-1, which instructs multipotent cortical precursors to generate astrocytes, thereby ensuring that gliogenesis does not occur until neurogenesis is largely complete.Neuron 11/2005; 48(2):253-65. · 15.77 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The molecular mechanisms responsible for inducing gene expression following neuronal injury are not well understood. Here, we address this issue by focusing upon C/EBPbeta, a transcription factor implicated in cellular injury and regeneration. We show that C/EBPbeta mRNA is expressed in neurons throughout the mature brain and that levels of both C/EBPbeta mRNA and phosphoprotein are increased in facial motor neurons following axonal injury. To determine the importance of these increases, we examined the regeneration-associated Talpha1 alpha-tubulin gene which contains functional C/EBP binding sites in its promoter. In transgenic mice, expression of a minimal 176 nucleotide Talpha1 alpha-tubulin promoter:nlacZ reporter gene was upregulated in injured facial motor neurons. This injury-induced transcriptional increase was inhibited in C/EBPbeta -/- mice. A similar inhibition was observed in C/EBPbeta -/- mice that carried a larger 1.1-kb promoter Talpha1:nlacZ reporter construct. Moreover, in situ hybridization revealed that the injury-induced upregulation of the endogenous mouse alpha1 alpha-tubulin mRNA, and of a second regeneration-associated mRNA, GAP-43, was inhibited in C/EBPbeta -/- mice. Thus, C/EBPbeta is essential for the neuronal injury response, acting to transcriptionally activate regeneration-associated gene expression.Molecular and Cellular Neuroscience 09/2005; 29(4):525-35. · 3.84 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: A fundamental question in stem cell research is whether cultured multipotent adult stem cells represent endogenous multipotent precursor cells. Here we address this question, focusing on SKPs, a cultured adult stem cell from the dermis that generates both neural and mesodermal progeny. We show that SKPs derive from endogenous adult dermal precursors that exhibit properties similar to embryonic neural-crest stem cells. We demonstrate that these endogenous SKPs can first be isolated from skin during embryogenesis and that they persist into adulthood, with a niche in the papillae of hair and whisker follicles. Furthermore, lineage analysis indicates that both hair and whisker follicle dermal papillae contain neural-crest-derived cells, and that SKPs from the whisker pad are of neural-crest origin. We propose that SKPs represent an endogenous embryonic precursor cell that arises in peripheral tissues such as skin during development and maintains multipotency into adulthood.Nature Cell Biology 12/2004; 6(11):1082-93. · 20.76 Impact Factor
Article: Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons.[Show abstract] [Hide abstract]
ABSTRACT: Recently, we reported that chronically axotomized rubrospinal neurons survive for up to 1 year in an atrophied state. This finding contrasted previous work suggesting the death of up to 50% of the neurons over time. In the adult mouse, the majority of facial motoneurons appear to be lost as a result of chronic nerve resection. Here, we sought to determine if chronically resected adult mouse facial motoneurons, like rubrospinal neurons, survive in an atrophied state. To test this hypothesis, we asked whether a second nerve injury, 10 weeks after an initial nerve resection, could stimulate a regenerative cell body response. After chronic resection (10 weeks), mouse facial motoneurons underwent atrophy resulting in a loss of countable neuronal cell bodies. In addition, the motoneurons failed to maintain their initial increase in expression of GAP-43 and alpha-tubulin mRNA. Reinjury of 10-week chronically resected facial motoneurons by the removal of the neuroma reversed the atrophy of the cell bodies and increased the percentage of identifiable cell bodies from 36% of contralateral to 79% in C57BL/6-C3H mice and from 28% of contralateral to 40% in Balb/c mice. Moreover, the reinjured motoneurons displayed an increase in GAP-43 and alpha-tubulin mRNA expression. The results of this study indicate that a second axon injury stimulates regenerative cell body responses in chronically resected mouse facial motoneurons and suggest previous studies using this model may have overestimated the number of dying motoneurons.Experimental Neurology 09/2004; 188(2):331-40. · 4.65 Impact Factor
Article: In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons.[Show abstract] [Hide abstract]
ABSTRACT: Axotomy induces apoptosis in motoneurons of neonatal rodents. To identify the key players in motoneuron apoptosis, we assessed the progression of apoptosis at 4 h intervals following facial motoneuron axotomy. The mitochondrial release of cytochrome c, caspase-3 activation and nuclear condensation were first observed in the motoneuron cell bodies 16 h postaxotomy. In vivo application of inhibitors of the mitochondrial permeability transition pore, Bongkrekic acid and cyclosporin A prevented cytochrome c release as well as caspase-3 activation and attenuated motoneuron apoptosis. Similarly, in vivo application of RU360, an inhibitor of the mitochondrial calcium uniporter, also protected axotomized motoneurons from apoptosis. Taken together, our results show that cytochrome c release and subsequent caspase-3 activation are critical events that precipitate the apoptotic death of axotomized neonatal motoneurons in vivo. In addition, these results provide evidence that application of mitochondrial pore inhibitors in vivo can block the induction of apoptosis following motoneuron axotomy.Cell Death and Differentiation 10/2003; 10(9):969-76. · 8.37 Impact Factor
Top Journals
- Experimental Neurology (3)
- Hippocampus (2)
- European Journal of Neuroscience (2)
- Nature Cell Biology (2)
- Neuroscience (2)
Université de Montréal
Montréal, Quebec, Canada
- Department of Pathology and Cell Biology
University of Toronto
Toronto, Ontario, Canada
- Hospital for Sick Children
SickKidsToronto, Ontario, Canada
University of British Columbia - Vancouver
Vancouver, British Columbia, Canada
- • International Collaboration on Repair Discoveries (ICORD)
- • Department of Zoology


text:
Sports & Outdoors
Items 1 to 10 of 74 total
Grid List
Gerber 30-000118 F.A.S.T. Technology Serrated Edge Clip Folding KnifeF.A.S.T. forward action spring technology. G-10 handle for extra grip when wet. Tanto shaped blade is designed for thrusting. Pocket clip, blade length 3.75-Inch, serrated edge. Over all length... Learn More$100.00
Gerber 06 Fast - Tanto, SerratedGerber. 31-000216. Folding... Learn More$100.00
Gerber 07564 Pro Scout Needlenose with Tool Kit - Multi-Plier 600Gerber Pro-Scout Needlenose Multi-Plier with 12 tools including saw coupler and can opener. Stainless steel construction. Tool kit with adapter and six bits. Tools lock for safety. Limited lifetime... Learn More$103.35
Astra Astra4000Rs-Dbp Alarm and Remote Starter with Two 5-Button Transmitters and Data PortComplete Remote Security & Engine Start System. 2 Car Operation With 1-Way Remotes. Plug-In Dual-Zone Impact Sensor. Plug-In User Programmable Coded Override Switch & Led On Antenna. Built-In Programmable Parking Light Relay... Learn More$103.99
Gerber Blades Strata Multi Plier Sheath ClamStrata Multi-Plier w/ SheathSlim, sleek and packed with functionality, the Strata delivers spring... Learn More$104.00
Garmin Foot PodAttaches to shoe.Transmits distance and pace data to Garmin Forerunner... Learn More$106.99
Gerber 22-41545 Black Diesel Multi-Plier with SheathComponents needle nose pliers, wire cutter, partially serrated knife blade, cross point screwdriver, small, medium and large flat blade screwdrivers, can opener, bottle opener, file, saw and scissors. One handed opening. Fully locked blades. Overall length 6.61-Inch, closed... Learn More$107.27
Reflekt Polarized - Tempest - Walnut Tort Frame-Reactor Polarized Brown LensesPolarized Lenses. Case Included.... Learn More$107.99
Reflekt Synth Sunglassesplastic frame.anti-reflective lens.polarized.Lens width:... Learn More$108.99
Pyle Sports PHRM22 Marathon Heart Rate Watch with USB and 3D Walking/Running SensorCaliation function.Chronograph with 100 laps memory record.4 training modes: target distance-2 for user's preset distances, half marathon, full marathon.Time/date daily alarm.4 training modes: 2 for user's preset distances, half marathon & full marathon modes.Current, average,... Learn More$108.99


text:
You must log in to access this feature. Sign in with Twellow or Facebook to get started.
By signing in to Twellow, you indicate your agreement to our terms of service.
Simply connect with Facebook and kiss those password blues away,
or go here to reset your password.
I am originally from Haverhill, MA. I am a US Army veteran of the Military Police Corps. I am a huge Red Sox and Patriots fan.


text:
Nostalgic cakes
Original review seen at: http://www.amiehu.com/2014/10/dong-po-colonial-cafe.html
When you think of nostalgic cafes, the ones that come to your mind are probably Sinpopo Brand, Tian Kee, Sin Lee, CMC Confectionery. There's no reason to miss out Dong Po Colonial Cafe, which specializes in so much cake, you can stuff yourself silly and still keep your wallets happy.
One of the most amusing non-cake items: 3-hole cookie!


text:
Anthony Hopkins to Bryan Cranston: You're the Best Actor Ever!by Hilton Hater at . Updated at . Comments
Bryan Cranston has three Emmy Awards on his mantel.
But it may end up being a framed letter that becomes the actor's most prized possession.
Two weeks after the Breaking Bad finale that rocked the television universe, Cranston received a written message from Sir Anthony Hopkins that gave the AMC show, its crew and its cast the highest of praise.
It also said Cranston put on the "best acting" Hopkins has ever seen.
And this man has seen some acting in his time!
Scroll down to read the full letter from the Academy Award-winning legend:
Dear Mister Cranston.
I wanted to write you this email - so I am contacting you through Jeremy Barber - I take it we are both represented by UTA . Great agency.
I've just finished a marathon of watching "BREAKING BAD" - from episode one of the First Season - to the last eight episodes of the Sixth Season. (I downloaded the last season on AMAZON) A total of two weeks (addictive) viewing.
I have never watched anything like it. Brilliant!
Your performance as Walter White was the best acting I have seen - ever.
I know there is so much smoke blowing and sickening bullshit in this business, and I've sort of lost belief in anything really.
But this work of yours is spectacular - absolutely stunning. What is extraordinary, is the sheer power of everyone in the entire production. What was it? Five or six years in the making? How the producers (yourself being one of them), the writers, directors, cinematographers…. every department - casting etc. managed to keep the discipline and control from beginning to the end is (that over used word) awesome.
From what started as a black comedy, descended into a labyrinth of blood, destruction and hell. It was like a great Jacobean, Shakespearian or Greek Tragedy.
If you ever get a chance to - would you pass on my admiration to everyone - Anna Gunn, Dean Norris, Aaron Paul, Betsy Brandt, R.J. Mitte, Bob Odenkirk, Jonathan Banks, Steven Michael Quezada - everyone - everyone gave master classes of performance … The list is endless.
Thank you. That kind of work/artistry is rare, and when, once in a while, it occurs, as in this epic work, it restores confidence.
You and all the cast are the best actors I've ever seen.
That may sound like a good lung full of smoke blowing. But it is not. It's almost midnight out here in Malibu, and I felt compelled to write this email.
Congratulations and my deepest respect. You are truly a great, great actor.
This is a far stretch. Yes, he's great, but to me an actor is more than a few jobs and hit show. We have actors live Giovanni guy from " The Gift " the man can play all roles! He can play comedy-psycho. Michael Kane. .. is awesome! Sorry but his statement is cheap and compulsive
If I were Mr. Cranston, I think I would die pretty damn happy after that. And he wasn't lying, Bryan is one hell of a talented actor.
Wow what a compliment. Every word of it true. Bryan Cranston is amazing and there will never be another show quite like breaking bad. From start to finish was fantastic.


text:
Unlikely friendship
The Invention of Everything Else
By Samantha Hunt
Houghton Mifflin, 257 pages, $24
I took a journey with "The Invention of Everything Else," a new novel based on the life of inventor Nikola Tesla, by Samantha Hunt. There were the first glorious seven pages of prose: daring and delicious, perfectly calibrated, fresh but not raw, original but neither off-putting nor disconcertingly strange. "Lightning first," the book begins, "then the thunder. And in between the two I'm reminded of a secret." Oh, I thought, I smiled, I'm in the hands of talent.
A shift then, midway through Page 7, to something a bit gushing and idiosyncratic -- precariously forced, it seemed to me, overly precious:
"I forget all thoughts of humans. I even forget about what I was searching for in the wall of drawers until, staring out at the sky, I don't forget anymore."
A greater strangeness then crept in and held, as talking pigeons entered the tale, and time-machine rides, scenes that registered as slapstick to me, descriptions that I'd pause over and parse: "The city began to scream as the rope pulley carrying a square cord of lumber to be used in dock construction gave way and fell to the cobbled street with a terrific crash." Had the city opened its mouth and bellowed? I wondered, I tried to picture it. Is "scream" the right word for this brand of crash and commotion? Or: "Louisa can't make out the words, only that there are words being said in a slow stream that rises and falls like a minister bringing a noisy congregation to order." A stream that rises like a minister, I'd read, and read again. And also: "As he turns to see what hit him, his face has streams of volcanic lava rising through the veins of his neck." Frankly, no matter how hard I tried, I couldn't make this physiology work; I just couldn't see it.
But there were high points, too, places where the language would stop me for all the right reasons -- a beautiful thought, beautifully put: "Azor is half crazy, but a part of her, a tiny room inside, wonders whether there might be a way to recognize someone you will love before you love him." And: "Even better than knowing is not knowing, is wanting to know everything and having to find out very, very slowly, like pulling a fishing line to the surface before you know what's on the hook." These sentences entranced me, I admired them, they made me eager to read on.
I should get to the plot. I should explain that "The Invention of Everything Else" is a history-infused invention, the story of Tesla's final days in the Hotel New Yorker, where the 86-year-old creator of alternating-current electricity and wireless communication has stowed his papers and his tools, is beset by memories and has befriended pigeons. Tesla has lived a long, eccentric life -- bolstered and beset by a kind of brilliance that has put him on the frightening forefront of discovery and often, sadly, left him stranded, so that Guglielmo Marconi would ultimately take the glory and financial rewards for Tesla's work on the wireless transmission of messages and the wireless transmission of energy, so that Thomas Edison would work to circumvent him, and so that the Nobel Prize committee would, at the very last moment, reverse its plan to give Tesla science's high prize. In his final days, Tesla is a lonesome pauper with a heap of unpaid bills, and into his life, in Hunt's creation, comes a curious chambermaid named Louisa who has a habit of digging through the things of hotel patrons and finds herself a treasure trove when she enters Tesla's room.
Much of the novel concerns itself with Louisa, whose mother died during childbirth, whose father, Walter, is a night watchman at the library, and whose love life has recently been amplified by meeting an oddball named Arthur, who possesses a strange prescience, an other-worldly quality. Meanwhile, Walter's dear friend, Azor, is at work on a time machine that may transport Walter back to see his beloved wife once more. Like Tesla, Louisa has had a lifelong passion for pigeons, and this, among other things, forges a bridge between the two, as Louisa snoops her way into Tesla's past, and as Tesla retraces his own breakthroughs, heartbreaks, dreams.
Hunt uses multiple strategies and voices to convey Tesla's life story. At some points, Hunt has Tesla imagining himself in conversation with Samuel Clemens, a device that felt awkward and unnecessary to this reader. At others, Hunt has Louisa reading from old Tesla manuscripts. On other pages, Hunt has embedded scraps of interrogative conversation -- authorities squeezing Louisa for whatever she might know about Tesla, who, some think, could be dangerous, especially given the year, 1943, and the state of the world. On still other pages, Hunt takes us into the laboratories of Edison, whom she renders as a cruel sort whom animal lovers will especially despise.
The facts of Tesla's life are fascinating, and while there's a certain unwieldiness to the plot, and places where the language strains too hard, it's hard not to conclude that Hunt had her heart in the right place with this book, that her highest concerns are with wonder and love, with questions of survival. By the time I reached the last few pages, I was feeling admiration again -- caring about characters I often felt I'd lost midway through the book. Indeed, the book's most touching passage comes just pages from the end, when Louisa is remembering the nights she'd sometimes spend at the library with her father. This, I think, is Hunt at her very best:
"He would lead me into the stacks, seven stories of them, and my head would swoon. How could there be so much, so many lives, so many books that were, each one, filled with stories, filled with letters, as if the library were some sort of tremendous brain. Memories, histories. No wonder he loved it there. Each book was a doorway to the past, to the dead. And there was my father, watchman over all of that. He'd take my hand in his."
Beth Kephart's books include "Flow: The Life and Times of Philadelphia's Schuylkill River." She can be reached at beth-kephart.blogspot.com.Copyright © 2014, Chicago Tribune


text:
2014 Christmas and holiday parades
Find a parade near you!
Find a parade near you!
Learn more about an effort in support of the American Cancer Society.
Find the complete outlook for the 2015-17 state budget as presented by the state Department of Transportation.
Find Nov. 17-21, 2014, National Weather Service snow totals from the Buffalo, New York, area.
Links to websites which claim to have copies of Black Friday ads leaked from major national retailers
Sign up online to ring bells during your community's Christmastime red kettle campaign.
Visit the 511wi.gov website for current travel conditions around Wisconsin.
To register and to find more information on The Case Chase, click here.
Learn more about the deadly toxin, ricin.
Interested in reducing the amount of waste you toss into your trash and helping to minimize your environmental impact?
Learn more about local sales taxes and the possibility of Brown County adding one.
Find links to current maps of power outages.
Find the nomination form for the Golden Apple Awards.
Learn about when an Amber Alert will or will not be issued.
Click here for more information from the National Highway Traffic Safety Administration.
Click here to learn more about how to plan for your retirement.
Statewide, year-round program where citizens, students and the department work together to monitor wildlife with a network of trail cameras.
Learn more about a recent report on booster seat safety.
Find trick or treat times for Northeast Wisconsin communities.
Take a look at FVTC's new Public Safety Training Center, as seen from the air.
Some baby wipes have been recalled because of potential bacteria.
Learn more about the organization.
Evenflo is recalling more than 202,000 rear-facing infant seats because the buckles can become difficult to unlatch.
Learn more about Asian carp and what is being done to try to keep them out of Wisconsin waters.
Find complete information, rules and regulations on deer hunting in Wisconsin.
Catch up on the latest political news from FOX 11.


text:
Australian beef has been implicated in a recall of mince in the US after the meat tested positive for the potentially deadly E. coli bacteria.
Topics: food-safety, beef-cattle, livestock, rural, business-economics-and-finance, food-and-beverage, health, diseases-and-disorders, united-states, australia
Posted| Updated
A peace activist has been committed to trial on charges relating to an attack on a helicopter during a military exercise in central Queensland last year.
Topics: courts-and-trials, army, activism-and-lobbying, rockhampton-4700
Posted| Updated
A home in Esperance has been destroyed by fire.
Topics: residential, esperance-6450, kalgoorlie-6430
Mal Meninga and Ricky Stuart react to the controversial decision to award Greg Inglis a try in the Origin opener
Posted| Updated
Residents of the Tasmanian town of Ross hope a new convict interpretation centre will boost tourism.
Topics: rural-tourism, tourism, travel-and-tourism, ross-7209
Posted| Updated
The latest SA Health data shows blood lead levels among children at Port Pirie are on the rise.
The number of children with lead levels above the World Health Organisation's recommended limit increased to 29 per cent in the first three months of the year.
The news comes as the Environment Protection Authority prepares to impose tougher emission standards at the Nyrstar smelter.
Topics: child-health-and-behaviour, environmental-health, health-policy, environment, port-pirie-5540, adelaide-5000
Posted| Updated
The State Opposition and the Greens have lashed out at the Government's new drug awareness campaign targeting teenage cannabis users.
Topics: drugs-and-substance-abuse, wa, albany-6330, bunbury-6230, denmark-6333, esperance-6450, geraldton-6530, kalgoorlie-6430, karratha-6714, broome-6725, katanning-6317
Posted| Updated
Acid attack survivors who featured in an Oscar-winning documentary now fear reprisals if the film is broadcast in Pakistan.
Topics: documentary, arts-and-entertainment, film-movies, law-crime-and-justice, human, women, world-politics, pakistan
Posted| Updated
Union delegates want certainty for the safety of workers at the Mount Lyell Copper mine on Tasmania's west-coast after a rock fall last week.
Topics: mining-industry, mining-rural, queenstown-7467
A Yenda ammunition factory is proposing to double its production, manufacturing up to 20 million shotgun cartridges a year.
Topics: local-government, regional-development, yenda-2681, griffith-2680, wagga-wagga-2650
The inquest into the death of a toddler, has heard staff at Broken Hill Base Hospital did not weigh the boy before administering powerful drugs.
Topics: courts-and-trials, infant-health, health, law-crime-and-justice, broken-hill-2880
Musicians from across Australia and overseas are performing at the annual 'Blues on Broadbeach' festival on Queensland's Gold Coast, which begins today.
Topics: community-and-multicultural-festivals, blues, broadbeach-4218
Posted| Updated
French company Total says Darwin has the potential to develop as a major hub for the oil and gas industry but better infrastructure is needed for it to do so.
Topics: oil-and-gas, regional-development, sea-transport, darwin-0800, broome-6725
Tasmania's library service has defended security on its public computer systems, after a Hobart man admitted accessing child pornography at the State Library in Hobart.
Topics: crime, hobart-7000
The western Riverina town of Hillston is booming with this year's cotton harvest.
Topics: cotton, crop-harvesting, regional, hillston-2675, carrathool-2711, wagga-wagga-2650
A mining conference in Broken Hill has heard resources companies are in a good position to take advantage of growth in China.
Topics: mining-industry, business-economics-and-finance, economic-trends, broken-hill-2880
Australian researchers have discovered why people can develop life-threatening allergies after getting treatment for conditions like epilepsy and AIDS.
Topics: medical-research, research, allergies, drug-use, melbourne-3000
Deniliquin Police are trying to track firearms sold by a guns dealer at Koraleigh, near Swan Hill.
Topics: koraleigh-2735, wagga-wagga-2650, deniliquin-2710
There is concern a new flight schedule in Broken Hill will mean increased travel costs for local business people.
Topics: air-transport, business-economics-and-finance, small-business, broken-hill-2880
An offensive email sent to a Wagga councillor has sparked a proposed no confidence motion in the Mayor Kerry Pascoe and Deputy Mayor, Yvonne Braid.
Topics: local-government, wagga-wagga-2650
Broken Hill City Council says it is confident it will not have to pay the carbon tax.
Topics: local-government, pollution, tax, broken-hill-2880
Posted| Updated
Firefighters have put out a blaze at a major inner Brisbane charity store for the second time in as many months.
Topics: industrial-fires, charities-and-community-organisations, woolloongabba-4102
As excitement grows in Azerbaijan ahead of Eurovision, reports about alleged rights violations are capturing international attention.
Topics: arts-and-entertainment, popular-culture, music, human, azerbaijan
Posted| Updated
A senior federal Coalition figure has raised the prospect of holding public hearings as part of Parliament's investigation into crossbench MP Craig Thomson.
Topics: federal-parliament, government-and-politics, parliament, federal-government, australia
Posted| Updated
Hewlett-Packard has announced plans to slash 8 per cent of its global workforce by 2014 to save around $US3.5 billion a year in a major restructure.
Topics: computers-and-technology, company-news, business-economics-and-finance, united-states


text:
Promotion Terms & Conditions
- There is a limit of one coupon per order.
- Offer expires 11/24/2014 at 11:59PM ET.
- On sale items, NFL, MLB and NHL jerseys, World Series Championship Locker Room apparel, Nike Holiday Fleece, NFL Salute to Service apparel, MLB and NFL on field headwear, NASCAR die-cast, Under Armour apparel, gift cards, online gift certificates and select memorabilia are excluded from promotion.
HOME NFL San Francisco 49ers Gear San Francisco 49ers Gameday & Tailgate $20 to $40 (94 items) Product ID: 1077501
Main Content
- 18" Silver-tone Rollo chain accented with dangling team-colored beads
- Adjustable extender chain
- Lobster claw closure
- Lucite pendant displays polished team logo etched in black enamel
- Made in China
- NFL® necklace
- Officially licensed
- Textured silver tone metal circles offset pendant
49ers Fanatics also liked:
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


text:
Travel Hosts Exposed, Week of July 13, 2011
Tony sets his sights on Hong Kong, Andrew makes a shout out to Ruth Bourdain, the Ghost Adventure guys gas up and more.Filed under:
"Hong Kong from the Star Ferry." - Anthony Bourdain
Please forgive us, this gallery is really popular.
We sent a note to our support staff about the glitch you just experienced. Please click the button below to reload your content.
You May Also Like
Travel Hosts Exposed, Week of July 6, 2011
See what your favorite TV hosts were up to over the 4th of July weekend.
Top 10 No Reservations Moments
Anthony Bourdain and the crew have been traveling for nearly 8 years and during that time they've laughed, cried and laughed some more.
We Recommend
Travel Hosts Exposed, Week of May 18, 2011
(19 Photos)
Wildman's Top 5 spots in LA
Most Popular
Extreme Pools: Las Vegas
Check out some of the most extreme pools in Las Vegas, including Rehab ...
Views of Vegas
From a gondola ride through the canals of the Venetian to the laser ...
Behind the Scenes in the Ozarks
Join Tony as he hunts, arm-wrestles, and of course eats his way ...
Travel Pests
At home or on the road, insects and critters can be a pain when we ...
Week of November 4, 2011
A flooded Saint Mark's Square in Venice, the New York City Marathon ...
More Travel Inspirations
GAC America's Amusement Parks
Buckle up and take a tour of the most thrilling amusement parks in America.
3-Ingredient Apps for Thanksgiving
Try Food.com's quick and easy apps for a stress free turkey day.
Food Network's Top Turkey Day Tips
Plan Your Menu with easy, how-to videos from Bobby, Sunny and more.


text:
Aquatic Invasive Species Specialists
RNT Consulting Inc. was established in 1998 to serve the needs of industries coping
with Aquatic Invasive Species. We have a unique combination of expertise including
engineering, biology, environmental science, and vulnerability assessment. Our specialty
is to apply a multidisciplinary approach to environmental problems, and we have just added
a terrestrial ecologist to our team.
We have extensive experience with the control and mitigation of biofouling, as well
as solving problems caused by aquatic invasive species. We apply both proven and
innovative technologies appropriate to the situation, and we work closely with our
clients to develop solutions best suited to their needs.
Contact us for more information on how to deal with aquatic
invasive species.


text:
Nick Cannon Regrets His Mariah Carey Tattoo
Nick Cannon and Mariah Carey have called time on their marriage and Nick is now regretting his decision to have the singer's name tattooed onto his back. It's a tough lesson, but never get someone's name tattooed onto your skin.
Nick said that it has been a pretty painful process in covering up the ink that he got done in honor of his estranged wife. Recently, photos of the TV host appeared online showing his partial coverage of the "Mariah" tattoo with what appears to be Jesus Christ.
During an interview with Meredith Vieira, Nick revealed of his new ink, "It's like a whole work of art, my entire back and my arm and everything. I was leaving the gym going into the studio just having had that work done and they [the paparazzi] got me. It's going to be a big reveal eventually, but it's not finished, it's half-way done. It's a lot of pain."
He then told Meredith to never get a tattoo of someone's name after she asked him what kind of ink she should get. Fitting advice, no?
Source, Photo Credit: Fame/Flynet
Filed under Mariah Carey, Nick Cannon | No Comments


text:
Recreational and commercial blue crab traps in state waters from the Palm Beach-Broward county line to the Pasco-Hernando county line must be removed from the water before July 10, the first day of a 10-day trap closure. This closure will give groups authorized by the Florida Fish and Wildlife Conservation Commission the opportunity to identify and retrieve lost and abandoned blue crab traps from the water.
Traps can be placed back in the water on July 20. Until then, blue crabs may be harvested with other gear, such as dip nets and fold-up traps. Blue crab harvesters may also use standard blue crab traps during the closure if the traps are attached to a dock or other private property.


text:
Story: Nov 24, 2014
Artist-in-residence Chi-Yu Liao appreciates CIA reception
CIA Exhibition: Nov 07, 2014
Fall 2014 Exhibitions
Story: Nov 15, 2014
Students capture two of the top prizes in museum's surreal d...
Events: Dec 01, 2014
The Art of Designing Everything
Social: about 4 hours ago via Facebook
Further evidence that CIA folks are all over the creative economy: Cleveland public radios David C. Barnett drills down into a recent 110-page report on the ec...
Story: Nov 04, 2014
New CIA building taking shape; set for December completion
Events: Dec 05, 2014
Student Holiday Craft Sale
Story: Aug 18, 2014
CIA again named to "Best in the Midwest" list
Academics . Community Works
Cleveland Institute of Art dedicates its 2014-15 academic year to an in-depth look at the many roles of art and artists in society with Community Works: Artist as Social Agent.
Community Works: Artist as Social Agent is a multilayered, year-long effort exploring the nature of art and social engagement through:
From September 2014 through May 2015, these events and people will help the CIA community explore new opportunities for artists, designers, urban neighbors, and other community partners to work together in order to effect positive civic engagement and social change.
"By bringing in visiting artists and speakers who represent a variety of perspectives and backgrounds, we hope to present a comprehensive look at the range of expression that may be considered socially engaged art," said Bruce Checefsky, director of CIA's Reinberger Galleries.
In addition to the elements listed above, Community Works: Artist as Social Agent will also include a community partnership in which medical students at the Cleveland Clinic Lerner College of Medicine will take a portraiture class taught by CIA faculty.
Artists and designers have a unique opportunity, and perhaps responsibility, to address social and civic concerns, engaging their talents and skills to bring about positive transformations and connections focused on civic engagement, community organizing, social change, social justice, participatory democracy, community building, and community development. Artists and designers can lend a voice – or an image, or meaning – to complex social and public processes and spaces, creating an ever-evolving community dialogue. Public engagement and urban revitalization are at the heart of this yearlong series of Community Works activities that CIA is undertaking.
Over the course of the year, CIA in partnership with other members of the community will openly seek answers to questions such as:
Addressing these questions will enable the CIA community to spark public discourse on the underlying theories, politics, and feasibility of social engagement projects in Greater Cleveland.
The programs included in Community Works are examples of Cores + Connections, CIA's academic mission in which core values of faculty mentorship, studio and academic rigor, and state-of-the-art curriculum, all power extensive connections for student engagement in field-based experiential learning, real-world professional projects, and social practices in art and design.
CIA thanks its sponsors, Cuyahoga Arts & Culture, The George Gund Foundation, and the Cleveland Foundation through its Creative Fusion initiative. CIA's George P. Bickford Fund and its Louis D. Kacalieff Visiting Artists and Scholars Endowment are providing crucial support to Community Works. CIA also thanks the following community partners for their cooperation: Cleveland Clinic, and the Cleveland Metroparks.
Creating. Connecting. Building better futures.
September 26, 2014
Wilson Fellow, visiting artists, exhibitions, conference, and new courses reimagine the roles of artists in society more


text:
Clean and friendly hotel in a good location in Thollon les memises centre. We were close to the ski lift and I see that the hotel is also in a good position for the mountains in the summer as well. The hotel has parking inside and out and a tennis court. You can walk to a bakers, supermarket, restaurants and... More
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Hotels.com, Despegar.com, Priceline, TripOnline SA, Odigeo and Tingo so you can book your Bon Sejour Hotel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text:
looking for a ule body to finish up a pump build, post or pm me if you have one for sale. Pump milled is a plus. Thanks
It doesn't matter if someone made it and wants to sit on it. I know someone who made a gun, did all the work to get it up to a working gun, but it failed.
Yeah Keith have to agree with ^
Send me the VER and i will put on something nicer. Have a nice M86 frame i can trade you, so you won't be


text:
Browser does not support script.
Courses Home
Studying at Solent Home
International Home
Business & Community Home
Research Home
About Home
In addition to the courses below we run a broad range of credit-bearing Professional Development Units (PDUs).
Find out how PDUs work and see the full list of available courses|
What people are saying
"Study what you love, hone your craft and get out there. If you have talent, people will swarm to you."
Craig DavidInternational RnB star,Honorary Doctor of Music
Connect with us
Facebook Like us |
Twitter Follow us |
YouTube Watch us |
How to change the text size - A A A |
How to change colours |
Read more about accessibility|
Find out more about cookies|
Disclaimer| | Privacy policy| © Southampton Solent University
Main switchboard tel: 023 8201 3000


text:
This is a beautiful 1928 Packard 526 Sedan short base. It has been fully restored to original. Some modifications that has been done are the... More
1952 Packard Henney Pro street hearse. nut and bolt restoration, frame off. newly finished and professionally built by priest/mechanic. the car was in storage... More
1949 Packard belonged to my Grandfather. Runs smooth. Engine has been overhauled and gas tank has recently been removed and cleaned. New paint. Great... More
1935 Packard 1203 Sedan Super 8 Income potential for weddings, picnics, tours and studio photo shoots. Read more at http://nwcam.com/ClassifiedAds.html?cid=1&pid=6980&step=4#03U8MQ4x32dopuLy.99 Northwest Classic Auto Mall advertises this vehicle for the... More
A Rare Find—1926 Packard Single Six This fully restored (frame off) Packard is rarer than hen's teeth! Our '26 Packard is the convertible coupe (yes,... More
1934 Packard Model 1107 Victoria, re-creation, 225 miles, ps, pb, original Packard drivetrain, only 1 of 4 exist, build by coachbuilder Bayliff Coach Corp, sacrifice at... More
1955 Packard Clipper Custom four- door with torsion bar suspension and Power Bar radio. Overhauled engine, brake system, power steering cylinder, starter, torsion bar... More
1935 Packard 2 dr Coupe – Rumble SeatLS1 fuel injected motor. Automatic Overdrive transmission with Lokar shifter. Freshly painted Black base / clear coat.... More
This 1949 Packard 22nd series Custom 8 received a frame off restoration in the mid 80s and has held up well. The paint has... More
1953 Packard Mayfair 300 2 door hardtop, 8 cylinder in-line, ultramatic transmission, power steering, power brakes. Interior is newly redone to match sales document. New... More
Preservation 1950 Packard Super 8 Sedan; Califorina car and rust free. The car is in orginal condition except for paint and uphstery. For the... More
This 1927 Packard Phaeton -5P Model 301 Convertible features a Flat Head 6 Cly 6cyl Gasoline engine. It is equipped with a 4 Speed... More
1935 Packard Eight 1201 Victoria - Concours Restoration. Scored 96.5 out of 100. Near Perfect. Call for pricing.... More
Top of the line Super Custom Clipper. Former show winner still in excellent condition.... More
1930 Packard Series 733 Coupe For Sale Exceptional 1930 Packard Series 733 coupe. Two owners since new. The car was originally purchased by a father... More


text: tag:blogger.com,1999:blog-61596234926219767992014-11-27T04:05:00.641-06:00coffee with a canineMarshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-55728135029015548532014-11-27T04:05:00.000-06:002014-11-27T04:05:00.647-06:00Kristen Weber & SampsonWho is in the photo at right? I'm Kristen Weber, and this is my 8-year-old male pug, Sampson. I'm a freelance book editor and I run Shelf Pleasure, a website for women who love to read. What's the occasion for Coffee with a Canine? Sampson is my co-editor and cuddling companion while I read. He'll take every chance he can get to sit on my lap. I usually put a pillow on top of him and then my Marshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-18708961116274767892014-11-24T04:05:00.000-06:002014-11-24T04:05:00.747-06:00Michelle Larsen & SpokaneWho is in the photo at right? I am Michelle Larsen, a small animal emergency veterinarian and field veterinarian for VPI. That's Spokane aka my Spokie girl. She's a 5 year old female Border Collie Mix. What's the occasion for Coffee with a Canine? Spokane joined me at work today while dad is out of town. What's brewing? Fall favorite pumpkin spice latte with soy. Any treats for you or Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-34852214086020181662014-11-20T04:05:00.000-06:002014-11-20T04:05:00.467-06:00Meg Rosenburg & SimonWho is in the photo at right? That's me, Meg Rosenburg, and Simon, my 10-year-old mini schnauzer, hanging out on campus at Caltech. What's the occasion for Coffee with a Canine? Simon normally keeps me company at home while I brew myself coffee with our pourover setup, but Caltech's Red Door Cafe has a lot of outdoor seating and Simon's always up for a field trip! What's brewing? My go-to Marshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-40006732984770042242014-11-17T04:05:00.000-06:002014-11-17T04:05:00.263-06:00Kathy Hewitt & LucyWho is in the photo at right? Hi, that's me, Kathy, in the photo. I live in San Diego, CA with my favorite canine companion, Lucy and my husband, Bill. I'm also a new author of the mystery-suspense: A Life Unbroken: The Alex McKay Series by K.M. Hewitt. My dog's name is Lucy, and when I come home I often announce: Lucy, I'm home! Those of you who remember the 'I Love Lucy' show will thoroughly Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-60293486781223320572014-11-13T04:05:00.000-06:002014-11-13T04:05:00.033-06:00Laura Lane McNeal & AbbyWho is this in the photo? That's me, Laura Lane McNeal, author of the novel Dollbaby, letting my dog Abby have a go in my mother-in-law's garden after her morning walk. I live in New Orleans, where in mid-October it's still eighty-eight degrees, so we're about to head inside and enjoy the air-conditioning and a cold drink. Too warm for coffee, I'm afraid. Abby is a three-year-old West Highland Marshal email@example.com:blogger.com,1999:blog-6159623492621976799.post-3658609567416031962014-11-10T04:05:00.000-06:002014-11-10T04:05:00.749-06:00Karen Miller & Seiko, Wilson, and MillieWho is in the photo at right? So, the person in the photo not a zombie canine is Karen Miller, speculative fiction author. And the zombie canines are from left to right: Seiko (aka Psycho), cocker spaniel/poodle, male, 18 months; Wilson, Maltese terrier/jack russell, male, 5 years and Millie, Maltese terrier/poodle, female, 6 years. What's the occasion for Coffee with a Canine? Since I don't Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-64016016652760327572014-11-06T04:05:00.000-06:002014-11-06T09:58:15.591-06:00Peg Kehret & LucyWho is in the photo at right? I'm Peg Kehret, children's book author and a long time volunteer with animal rescue groups. My biggest claim to fame is that my books have won fifty state young reader awards. My dog, Lucy, is twelve, a mixed breed rescued dog. What's the occasion for Coffee with a Canine? We're celebrating the release of my new book, Dangerous Deception (Dutton Children's Books)Marshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-70761051968458110482014-11-03T04:05:00.000-06:002014-11-03T04:05:00.268-06:00Lisa Russo & LuluWho is in the photo at right? That's me and my shadow, having a morning snuggle and kiss. I'm Lisa Russo, a fine art photographer. You can find me at Lisa Russo Fine Art Photography. My furry friend is Lulu, our little girl bulldog who turned 6 this summer. What's the occasion for Coffee with a Canine? Just saying goodbye before I head off to the gym before returning home for my workday. Marshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-29580260818057206712014-10-30T04:05:00.000-05:002014-10-30T04:05:00.174-05:00Jane Isaac & BolloWho is in the photo at right? Jane Isaac, UK based author of psychological crime thrillers, An Unfamiliar Murder and The Truth Will Out. And four-year-old Lab cross, Bollo, my fun-loving trusted companion. What's the occasion for Coffee with a Canine? I have my morning brew with Bollo every morning before the rest of the household awakes. In the summertime, if it's fine we'll take it out into Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-492221313606735382014-10-27T04:05:00.000-05:002014-10-27T04:05:00.603-05:00Yona Zeldis McDonough & Willa and HoldenWho is in the photo at right? Yona Zeldis McDonough, a novelist and children's book author. Dogs are Willa, a female Pomeranian who is about eight, and Holden, a male Pom who is seven. What's the occasion for Coffee with a Canine? I always have a morning latte and in the warm weather, an iced coffee late in the afternoon. I have to feed Willa and Holden before I have my morning brew because Marshal email@example.com:blogger.com,1999:blog-6159623492621976799.post-44904394483323243172014-10-23T04:05:00.000-05:002014-10-23T11:51:37.892-05:00Kevin Lee Jacobs & LilyWho is in the photo at right? I'm Kevin Lee Jacobs, the creator of the food and lifestyle blog A Garden for the House. In my arms is Lily the Beagle, my 6 1/2-year-old best friend. She's also my sous-chef and, on occasion, my taste-tester. A more enthusiastic kitchen-helper doesn't exist. What's the occasion for Coffee with a Canine? Just now we're enjoying the morning sunshine in the Herb Marshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-71777563784874007582014-10-20T04:05:00.000-05:002014-10-20T13:14:54.018-05:00Dan Richards & FreddyWho is in the photo at right? Hi! My name is Dan Richards. I'm a children's author. My debut picture book The Problem With Not Being Scared Of Monsters came out August 1st of this year. Next to me is my 7 year old Golden Doodle buddy Freddy. What's the occasion for Coffee with a Canine? To be honest, neither of us drink coffee so we got together to prove it was possible to take a photo with usMarshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-62998846357403022762014-10-16T04:05:00.000-05:002014-10-16T04:05:00.460-05:00Catherine Reef & NandiWho is in the photo at right? Greetings! I am Catherine Reef, a hardworking author of nonfiction books for young people and adults. The gentleman with me is Nandi, an eleven-year-old Italian greyhound. What's the occasion for Coffee with a Canine? We are taking a break to check on the progress in our garden. What's brewing? Nothing fancy. I am having my usual half-caff blend brewed with Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-86595205869699101432014-10-13T04:05:00.000-05:002014-10-13T04:05:00.144-05:00Tania Malik & DeuceWho is in the photo at right? The photo is of me, Tania Malik, and my dog, Deuce, an eight-year-old cockapoo. I am mother to a teenage daughter and a writer. What's the occasion for Coffee with a Canine? After our morning walk, Deuce and I take up our usual positions. I am on my laptop, sitting at my desk or on the couch. Deuce sleeps nearby or is curled up next to me. What's brewing? A cup Marshal firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-4722303895640953812014-10-09T04:05:00.000-05:002014-10-09T04:05:00.148-05:00Holly Schindler & JakeWho is in the photo at right? Me (Holly Schindler, author of both YA and MG novels, most recently the YA Feral, which received a starred review from Publishers Weekly) and my Pekingese, Jake. What the occasion for Coffee with a Canine? Every day is coffee with a canine. We've been together for eleven years—that's a whole lotta coffee and a whole lotta manuscripts between us. What's brewing? Marshal firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-67508479073871441572014-10-06T04:05:00.000-05:002014-10-06T04:05:00.225-05:00J.M. Hayes & Kacy and AllieWho is in the photo at right? That's our formal family portrait, left to right, Jalepenio Kacydilla (Kacy), J.M. Hayes (me), and Allielujah (Allie). Kacy is six, Allie, five. I'm a little older and I write mystery novels for Poisoned Pen Press. The girls are both German Shepherds. I'm of Anglo-Irish descent with a little Neanderthal DNA. What's the occasion for Coffee with a Canine? We're Marshal firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-42431418244011506932014-10-02T04:05:00.000-05:002014-10-02T04:05:00.762-05:00Steve Caplan & GingerWho is in the photo at right? Allow me to introduce Ginger, my great friend and ~5 year old female Vizsla-Labrador retriever, pointer and setter! Oh, and I'm Steve Caplan, a professor of Biochemistry and Molecular Biology at the University of Nebraska Medical Center in Omaha, Nebraska. I study membrane trafficking, but in addition, I'm a published author of fiction who has written 3 novels that Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-82086125246669053192014-09-29T04:05:00.000-05:002014-09-29T07:40:04.839-05:00Dori Hillestad Butler & MouseWho is in the photo at right? The cute one is Mouse. He's a 102-pound golden retriever mix. I'm Dori Hillestad Butler and I'm a children's book author. What's the occasion for Coffee with a Canine? Launching my new children's book series, The Haunted Library. What's brewing? A perfect cup of coffee. Black. My husband orders green coffee beans from all over the world and then he roasts them Marshal email@example.com:blogger.com,1999:blog-6159623492621976799.post-80106536457196750652014-09-25T04:05:00.000-05:002014-09-25T04:05:00.175-05:00Andi Cumbo-Floyd & Bella, Boone and MeanderWho are in these photos? And what's the occasion for Coffee with a Canine? I'm Andi Cumbo-Floyd — writer, a teacher, an editor, and a reader. Today, the pups and I are sharing coffee because, well, because it's today, and every day is a good day to spend with a dog. I've come out to the pasture — where Bella and Boone, the Great Pyrenees live — and Meander, our house dog, has wandered out, tooMarshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-57539792293300144862014-09-22T04:05:00.000-05:002014-09-22T04:05:00.131-05:00EJ Hanagan & Brody and BaxterWho is in the photo at the right? Brody and I are goofing off in the photo at the right. The other picture is Baxter posing for the camera on one of our car rides. Both boys are going on 7 years old. They are Newfoundlands. Baxter, the black and white one is called a Landseer Newfoundland because of his markings. My name is EJ Hanagan, author of Saving Jason. What's the occasion for Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-64596623105376821652014-09-18T04:05:00.000-05:002014-09-18T04:05:00.409-05:00Holly Menino & KeelWho is in the photo at right? The one with less hair is me, Holly Menino, author of mysteries and a good bit of nonfiction. The one with all the curly black stuff is Keel, a Portuguese Water Dog. Now that she's ten she doesn't like to give her age. Thinks she might be expected to act it. What's the occasion for Coffee with a Canine? The occasion is morning, and it happens every day. But it Marshal firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-37622250886284291452014-09-15T04:05:00.000-05:002014-09-15T04:05:00.198-05:00Michelle Rae & EvaWho is in the photo at right? This is a picture of me and my ten-year-old Jack Russell Terrier, Eva, on my wedding day at the Richard Nixon Library in Yorba Linda, California. We had to have written permission from the government to have her there that day. My name is Michelle, a Midwest girl living in Southern California. Most of my week is spent working in the training department at the Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-79719557180910296522014-09-11T04:05:00.000-05:002014-09-11T04:05:00.034-05:00Monica Medina & Henry and Oliver TwistWho is in the photo at right? That's me, Monica Medina, with my boys. I'm holding Oliver Twist, a one-year-old Maltipoo street urchin I literally found on the streets of San Diego. On the bench is Henry, my Cavalier King Charles Spaniel who recently was traumatized when he turned seven and heard the vet refer to him as a "senior dog." Henry, who claims he descends from royalty, insists he's not Marshal Zeringuehttp://email@example.com:blogger.com,1999:blog-6159623492621976799.post-21743647624247294582014-09-08T04:05:00.000-05:002014-09-08T04:05:00.224-05:00Lisa R. Petty & Sophie and LolaWho is in the photo at right? I'm Lisa R. Petty. I use the R. because there is another Lisa Petty who writes beauty books -- so not me. I'm a blogger who also writes realistic YA Fiction. I am also an online English professor. I'm with Sophie, my Black Lab Great Dane, and Lola, my Maltese who fears thunder and needed to be held for the picture. What's the occasion for Coffee with a Canine? Marshal Zeringuehttp://firstname.lastname@example.com:blogger.com,1999:blog-6159623492621976799.post-44130420968878075232014-09-04T04:05:00.000-05:002014-09-04T04:05:00.551-05:00Matthew Gilbert & TobyWho is in the photo at right? Matthew Gilbert, TV critic at the Boston Globe, author of the new book Off the Leash: A Year at the Dog Park, and human Pez dispenser for a male yellow lab named Toby, age 9. What's the occasion for Coffee with a Canine? I can't function happily without coffee, and I can't function happily without Toby. So this is double pleasure. What's brewing? I'm a Marshal Zeringuehttp://email@example.com


text:
Vladimir can get out of Jarvan's ult with the pool, he just walked straight through it, it looked kinda glitchy, but managed to get out fast. This happened repeatedly throughout the game, so it's not a one time bug
Unfortunatly, its just the way his ult works. Ghost lets you run though his ult as well. Any ability/effect that lets you pass through units will let you out of his ult. I think Hecarium can NEVER get stuck in his ult, but i'm not sure on that
Lord Gildarts
Senior Member
Oh god just think about anyone with a phantom dancer.
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


text:
Friday, April 3, 2009
How Autofocus Works
What to know about today's autofocus technologies
Labels: Cameras, Still Cameras, DSLRs, How To
Phase-detection AF systems are found in SLR cameras. In digital SLRs, phase-detection technology uses an additional sensor (separate from the imaging sensor) to achieve focus. In modern D-SLRs, the reflex mirror is partially transparent so that light coming in through the lens can reflect down onto a sub-mirror, which reflects that bounced light onto the AF sensor.
On top of the AF sensor is a set of precision optics that splits incoming light into two separate beams. Based on where these two beams strike it, the sensor can determine how far out of focus your image is and whether focus is in front of or behind the focal plane. Once the AF sensor does this calculation, accurate focus is established. The calculation is performed in milliseconds and can be done repeatedly at a very fast rate, giving the camera the ability to continually change focus or automatically track a fast-moving subject.
Panasonic Lumix DMC-FS15
Contrast-detection autofocus is the primary AF system used in compact point-and-shoot cameras; many D-SLRs also use it for autofocusing in Live View mode. This form of autofocus differs because it uses the same sensor—the image sensor—for both autofocus and image capture. The AF system analyzes the scene and tries to find contrast.
It typically starts with the lens at the infinity position and moves step by step to the close end of the focusing range, gauging the contrast to see if it increases or decreases.
As the contrast increases, the system knows it's getting closer to an accurate focusing point. Once it passes this point and the contrast begins to decrease, the system has identified the peak of contrast and locks down focus at the peak.
Page 1 of 2