text:
This page is for collecting feedback from Wiktionary readers. It should be cleaned out regularly, as new comments are constantly being added. Feel free to reply to and discuss comments here, though bear in mind that the people who leave the feedback may never come back to read replies.
- Links: Collected feedback • Wiki Javascript (for adding to your WMF Wiki.)
- 1 October 2014
- 1.1 Special:Search like Wikipedia
- 1.2 hypo-
- 1.3 Category:Translingual punctuation marks
- 1.4 Wiktionary talk:Shortcut
- 1.6 Appendix:English pronunciation
- 1.7 chimici
- 1.8 Foreign word of the day: anataño
- 1.9 thematize
- 1.10 malefactorum
- 1.11 Wiktionary:Word of the day
- 1.12 presentato
- 1.13 Category:Requests for quotation/Donne
- 1.14 приняться
- 1.15 Category:English words prefixed with ex-
- 1.16 Word of the day: croggy
- 1.17 arraigar Verb table correction
- 1.18 Special:Search
- 1.19 violenti
- 1.20 osteotropic
- 1.21 Foreign word of the day: πρέπω
- 1.22 Wiktionary talk:Requested entries (English)
- 1.23 Talk:passé
- 1.24 Special:RecentChangesLinked/Wiktionary:Frequency lists/Norwegian Bokmål wordlist
- 1.25 maritus
- 1.26 ljóðlist
- 1.27 Wiktionary:Main PagePronunciation
- 1.28 Umwelt
- 1.29 Word of the day: sparge
- 1.30 innamorato
- 1.31 interstice
- 1.32 przynosić
- 1.33 Word of the day: unciform
- 1.34 nuclear power plant
- 1.35 Layout
- 1.36 Special:Search
- 1.37 Foreign word of the day: رجاrzwe
- 1.38 Wiktionary:Feedback
- 1.39 moribundus
- 1.40 Word of the day: miniver
- 1.41 comprenc
- 1.42 primates
- 1.43 Wiktionary:Frequency lists/Serbo-Croatian wordlist
- 1.44 Wiktionary:Translation requests
- 1.45 Brownie point
- 1.46 Special:Search
- 1.47 frugi
- 1.48 breathe
- 1.49 trimestre
- 1.50 Appendix:Latin third declension
- 1.51 hippopotomonstrosesquipedaliophobia
- 1.52 capisce THANX ALOT,
- 1.53 Wiktionary talk:Main Page
- 1.54 كوكب
- 1.55 Talk:provoto
- 1.56 raster
- 1.57 Appendix:Proto-Germanic/sunþaz
- 1.58 survivour
- 2 November 2014
- 2.1 allopathic
- 2.2 Foreign word of the day: comprehendō
- 2.3 Appendix:Proto-Germanic/snidaz
- 2.4 criminalizar
- 2.5 criminalizar
- 2.6 Special:translators
- 2.7 Word of the day: mara
- 2.8 trance
- 2.9 Special:Search
- 2.10 CHF Correct Writing?
- 2.11 Category:English words prefixed with post-
- 2.12 technical
- 2.13 Australia
- 2.14 δεν
- 2.15 Special:Search/Aran Economic Region
- 2.16 religion
- 2.17 Special:Search खानदान
- 2.18 chock full
- 2.19 cuid
- 2.20 duende
- 2.21 fluidl
- 2.22 shit-eating grin
- 2.23 Special:Search
- 2.25 Wiktionary:Main Page
- 2.26 prendersela
- 2.27 circle jerk
- 2.28 Good web site
- 2.29 Wiktionary:Main Page
- 2.30 Jógvan
- 2.31 Lookups Should Be Quicker, With Default Language
- 2.32 osculate
- 2.33 breca
- 2.34 Category:English words prefixed with semi-
- 2.35 Category:Italian phrases
- 2.36 píka
- 2.37 dum dumi want list of voters current area subhashnagar south dumdum
- 2.38 screw the pooch
- 2.39 vand
- 2.40 Special:Search
- 2.41 Appendix:Proto-Germanic/habrô
- 2.42 spring tide
- 2.43 Special:Categories
- 2.44 Category:French words suffixed with -eau
- 2.45 Talk:droga
- 2.46 Appendix:Proto-Germanic/kelþą
- 2.47 mind one's ps and qs
- 2.48 barbecue
October 2014[edit]
Special:Search like Wikipedia[edit]
If I type the title of an existing entry correctly, why are you making me do the clicking too? Can it not be as it is on Wikipedia? Correct search term => here's the page. Thanks. --Matija, 08:11, 1 October 2014 (UTC)
- You did not give us a real life example, so we have to guess at what you mean. So, if you type biggest, you either want it to automatically redirect to big, or you want a complete entry at biggest, including definition? We experimented with this years ago, and people complained about misspellings such as concieve automatically redirecting to conceive, because then they did not realize that they were misspelling it. They wanted to see the page that explained that it was a misspelling of conceive, and then they can knowingly click on conceive. If a Latin student types permittere, you want it to automatically redirect to permittō. If that happened, it would be much harder for the student to find out what part of speech permittere was. We tested exhaustively many different scenarios until we settled on what we have now. So the answer to your question is, no, it cannot be as it is on Wikipedia. On Wikipedia, you're just want to reach the article, however you might spell it or misspell it, so you can read the information in the article. Here we are a dictionary, and misspellings and various parts of speech are a big part of what we are about. Furthermore, we are a dictionary not just of English words, but of words in any language. A misspelling in English is sometimes a real spelling in another language; a finite verb in English may be an infinitive in another language. So we generally do not have automatic redirects here. Redirects conceal information that is important to our readers, and redirects often end up at the wrong word, or even the wrong language. —Stephen (Talk)
11:18, 1 October 2014 (UTC)
- That's in a large part caused by Wiktionary's limited software though. There's no reason computers cannot state spelling errors, parts of speech and so on and the definitions in one go.
Thanks for this awesome website! Keep up the awesome work!
Just want you to know you guys are the most amazing website ever.
Category:Translingual punctuation marks[edit]
Emoticons are punctuation marks? Are you serious? --188.8.131.52 02:52, 2 October 2014 (UTC)
Wiktionary talk:Shortcut[edit]
How can I get Wiktionary removed from my computer? Every time I try to close all my windows, I have to deal with this one showing up and I can't figure out a way to make it go away. I would gladly have it as an icon on my toolbar, but this situation is quite annoying. Thank you for a response. Patricia Gray <redacted email>
- It is nothing that we are doing to your computer. It depends on the kind of computer and operating system, and what exactly you did to put Wiktionary on your computer. If it is a PC with Microsoft Windows, and you have something like "['w] https://en.wiktionary.org/wiki/", then hover your cursor over it, then right-click, delete. In any case, this is something that your computer and operating system have done for you, or to you, and we have nothing to do with it. —Stephen (Talk) 19:49, 2 October 2014 (UTC)
THANK U FOR HELP[edit]
Appendix:English pronunciation[edit]
Super helpful. Thanx!
The Italian word "chimici" is also an adjective.
Foreign word of the day: anataño[edit]
Antaño. No anataño.
Could you please add any synonyms? Would be great!
phoney post, read discussion on page
- I wonder why no one told w:Plautus that he was using a word that wouldn't be invented until 2000+ years after his death- I guess they didn't have very good internet access in those days... ;) Chuck Entz (talk) 13:26, 6 October 2014 (UTC)
- The talk page says it should be removed from Wikipedia, so that doesn't affect us. Renard Migrant (talk) 17:15, 6 October 2014 (UTC)
Wiktionary:Word of the day[edit]
Wiki LIVES!
The Italian word "presentato" is also an adjective.
- I fixed the verb form presentato, it:presentato doesn't list an adjective. What do you think it means? Renard Migrant (talk) 17:17, 6 October 2014 (UTC)
Category:Requests for quotation/Donne[edit]
The quotation from Donne would be as follows: "if this child of mine, inanimated by your gracious Acceptation, may so long preserve the Memory of ... JOHN DONNE." from Devotions 3.
PROBLEM: The conjugation randomly switches to заня́ться
- Thank you both! --Anatoli T. (обсудить/вклад) 04:11, 7 October 2014 (UTC)
Category:English words prefixed with ex-[edit]
your pages are fantastic i use them all the time. GOOD ON YA!
Word of the day: croggy[edit]
It would be helpful if you would discriminate between English variants for certain words. For example, I've never heard of the word "croggy". Is it British?
- I haven't heard of it here in northern England, and the OED haven't included it in any of their dictionaries yet, but I assume that they are considering it to include in their next update, or perhaps it is just in their database and will never make it into the dictionary. (The fact that Wiktionary has picked up the word makes it more likely that it will enter the language.) Looking at the authors who use it, I guess that it is restricted to the dialect of north-east England. This would explain why I've never heard it here in the north-west.
- I find the suggest etymology most unconvincing since the limpet sense is Cornish. I suggest that it is just a corruption of crossbar, but I have no more evidence for this than for the limpet suggestion. Dbfirs 10:01, 7 October 2014 (UTC)
arraigar Verb table correction[edit]
The conjugation table is incorrect for the verb "arraigar" in Portuguese. To it, as with other verbs ending in '-gar', a silent 'u' is adding after the 'g' to maintain its "hard" pronunciation, [ɡ] or [ɣ], rather than the pre-palatal [ʒ]. Therefore, the forms listed on the table ending in '-gei', '-ge', '-ges', '-gemos', '-geis', and '-gem' should be written '-guei', '-gue', '-gues', '-guemos', '-gueis', '-guem'.
Can you add some of your own ideas instead of posting stuff? thanks 4 reading my comment
The Italian word "violenti" is also an adjective.
- These are useful of course, but any chance you could add these yourself to save time? Renard Migrant (talk) 12:02, 10 October 2014 (UTC)
Thank you
Foreign word of the day: πρέπω[edit]
Kinda weird y'all leave out definition #3 on the page in the foreign word of the day blurb when that's how I see it used most often.
Wiktionary talk:Requested entries (English)[edit]
make it easier to add words steatohepatosis
Please include mp3 files in the html5 video and audio tags. Unable to play audio in IE V11.
- Most of our audio files are in .ogg format, so that would require a massive project to convert thousands of files. You just need to get a plugin that can handle the .ogg format. Chuck Entz (talk) 19:00, 13 October 2014 (UTC)
Special:RecentChangesLinked/Wiktionary:Frequency lists/Norwegian Bokmål wordlist[edit]
Many Danish words
Thanks, great.
The declension table under this word gives a plural form for the word, but the information given next to the word itself says that there is no plural (as with the word tónlist.) This makes the page unclear.
Wiktionary:Main PagePronunciation[edit]
I believe that there should be an explicit reference to the pronunciation key - it is not immediately obvious to the layman that you are using IPA characters, and it's not really that easy to find out even that.
- I'm pretty sure anyone who uses any respectable dictionary is aware that IPA exists. People who (for whatever reason) don't know can simply look up "Wiktionary pronunciation" or "Wiktionary pronunciation key". Tharthan (talk) 23:46, 15 October 2014 (UTC)
Kind of harsh...
- "One's surroundings or environment; the outer world as perceived by organisms within it." Who is this harsh to? Renard Migrant (talk) 16:59, 21 October 2014 (UTC)
Word of the day: sparge[edit]
I'm not very tech savvy but have a suggestion for a very commonly used Australian slang word to add to your Wiktionary... DILLIGAF: Do I Look Like I Give A Fuck... Trust me, it will only take a little research to find this to be true. Nominate as WORD OF STRAYA!... ELCY78 (talk) 10:11, 16 October 2014 (UTC)
On the understanding that I am not a great wordsmith and don't speak Italian... I edited innamorato adding the "Related terms" inamorato inamorata
I then noticed how unsynchronised the definition innamorato is with related terms and feminine equivalents It would be great if a more knowledgeable wordsmith than I would tidy this up Specifically I refer to the definitions of and "Related terms" listed for; inamorato inamorata innamorato innamorata
Sorry to say that given my current priorities and time constraints it is unlikely that I can make the necessary edits
- The one-n spellings "inamorato" etc. are English words, not Italian ones, so they shouldn't be added as Related terms to an Italian-language entry. —Aɴɢʀ (talk) 13:11, 16 October 2014 (UTC)
First time I saw this word was "the interstices of space" while reading Clarke's explanation of "2001". He was probably right. Of course, he was probably right about everything. Something to think about with a comet headed towards Mars. Glad to see it here. Thank you.
I think that the future tense here is not the future but the present tense.
Word of the day: unciform[edit]
I love how u always out the word of the DAY!!!! Keep on doing it!!!😄😄😜😜😋'
nuclear power plant[edit]
It is very practical .
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
I have a couple of observations about the layout of the entries in Wiktionary. It seems to me that it is confusing in two ways:
First, although there is a table of contents which is intended to help locate different sections within the entry, the section containing the meaning of the word (and which therefore forms the hyperlink in the contents), is not headed "meaning", but with the type of word it is, e.g. "adjective" or "noun". This means that the section heading does not actually say what is in the section, and that it is not consistent between entries. You may say that approach would not work when a word can form different parts of speech, but these different uses of the word should then be sub-sections within an overall "meaning" section. (Also, the section headings do not have the numbering which is used in the contents, which would also help useability).
Second, the section containing the meaning of a word is halfway down the list. Surely the meaning of the word would be the objective of a large majority of users, and should therefore be first in the list.
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Usage of computers and phones with small screens are forcing users to scroll down to see the meaning of words and this inconvenience is being saved into web pages and screen captures. As you do not pretend to be "didactic" at all costs, one would expect the meaning, etymology (and pronunciation) to be delivered at once and then go on to list the Contents as the display has become smaller as mentioned. Also the vertical space occcupied by Contents could be less, it seems.
- I have an android and it just collapses everything. If I want only the definition of the noun I just click on the section 'Noun' and I don't see anything else. Renard Migrant (talk) 14:55, 23 October 2014 (UTC)
- Oh, mine doesn't. Is there a special setting for small screens? Dbfirs 16:17, 23 October 2014 (UTC)
- We've had this discussion here before, in more detail, but nothing will come of it because Wiktionary uses the standard Wikimedia layout and that won't change. It should change, and it could, but it won't happen.
- Oh, mine doesn't. Is there a special setting for small screens? Dbfirs 16:17, 23 October 2014 (UTC)
Foreign word of the day: رجاrzwe[edit]
wguhf iwheiajh ihks jrhheztwh0 k89343 804309 z 5803207 8402 ÃĕÜÙ
very impressed with Wicking. Plan on making use of it. If allowed. Thank you and have a good day.
i think u r v good
Word of the day: miniver[edit]
Thanks for the word of the day! Now i know what the miniver is:
Don't parleu Catalanglish!
- Definitions are always in English, for definitions written in Catalan, go to ca:. However comprendre is Catalan of course, we can't put an English word in there without making it false now can we! Renard Migrant (talk) 18:07, 27 October 2014 (UTC)
Wiktionary:Frequency lists/Serbo-Croatian wordlist[edit]
It would be important to put the occurrence of lexems into the context of the totality of words, so everybody can calculate the percentage of appearence. Thank, otherwise a excellent work.
Wiktionary:Translation requests[edit]
it is a very nice program but there is no malayalam translation
- That's right. At the moment, we do not have anyone here who is doing Malayalam. We used to have a good Malayalam editor, but he left. Hopefully another one will come soon. —Stephen (Talk) 12:18, 26 October 2014 (UTC)
Brownie point[edit]
The Etymology section here gives the impression that the origin of this phrase is definitely known, whereas according to the Wikipedia article ([1]) it is anything but.
- Thank you. Perhaps someone didn't like the unpleasant truth. I've adjusted the entry, putting the most likely brownnose origin back, leaving the junior Girl Guide details as a likely influence. I don't think we need include all the other guesses, though it would be interesting to know if there is any early evidence for Kodak points. Dbfirs 21:58, 3 November 2014 (UTC)
good to have such things on the net upgrade our knowledge!!!!!!!!!!!!!!!
Frugi is also an adjective, see french version http://fr.wiktionary.org/wiki/frugi
Please put an OBVIOUS BOX next to OR NEAR the "word" that can be clicked on to HEAR the correct pronunciation of the word. I've found audio pronunciations before in the past but it has to be searched for and all too often I can't seem to locate it. I'll try searching elsewhere now. The history and meaning are important BUT so is how to say it correctly. Thanks.
- Did you click the box labeled "Audio (US)" in the Pronunciation section of breathe? I can't think how to make it more obvious. —Aɴɢʀ (talk) 18:03, 27 October 2014 (UTC)
Portuguese is missing?
Appendix:Latin third declension[edit]
capisce THANX ALOT,[edit]
Wiktionary talk:Main Page[edit]
There is no expression in Arabic called "كوكب سينمائي" to refer to "film star". "كوكب" is mostly used to refer to a planet, not a star. So in Arabic "نجم أفلام" is used, but not "كوكب سينمائي". I hope this get corrected.
Provoto was the name my husband and I made up one day it has no meaning we have the url and we used the name for our company -- my husband and I have made up many many names that we use -- so before you saw Provoto, it was not -- it became once we made it.
It means something
totally different that what you are saying, it is what it is and it is what it will be, single, plural, male, female, past, present, "It is PROVOTO"
Cindy Sanders
- Sorry, Cindy from Fort Wayne, Indiana, we don't recognise words that you and your husband have made up. They are called protologisms, and we don't have entries for them until they get used independently (not by you or your company). I think your company name has a capital letter which makes it different from the Esperanto word. Dbfirs 21:13, 30 October 2014 (UTC)
- I had a hamster called Tipperary, so what? Renard Migrant (talk) 23:19, 30 October 2014 (UTC)
Jumbling the letters in an anagram on each word's page is providing trivial information. It lowers the quality of the dictionary as a whole and interferes with searches.
- As a long-time Scrabble player, I wouldn't include them either! Anagrams reduce words (or phrases) to their mathematical properties. They're literally 100% divorced from meaning. Renard Migrant (talk) 23:16, 30 October 2014 (UTC)
- Pronunciation also has nothing to do with meaning, but we include those. Equinox ◑ 21:22, 1 November 2014 (UTC)
- But pronunciation is useful, as are homophones. Anagram I believe are not. Renard Migrant (talk) 12:19, 6 November 2014 (UTC)
- Pronunciation also has nothing to do with meaning, but we include those. Equinox ◑ 21:22, 1 November 2014 (UTC)
Hello, Should this not be *sunþą (neuter a-stem) to match the other cardinal points (*austą, *nurþą, *westą)? Also would you consider expanding the directional adverbs category to include further words ending in *-anē, such as:
- nurþanē, *sunþanē, *austanē, *westanē; *haimanē (< *haimaz); *undanē; *hwanē, *hinē, *þanē (these last 3 from Kroonen) — that is, if they are sufficiently attested in the daughter languages. I suppose the problem becomes one of match the above ablative adverbs with matching locative and allative equivalents. If I knew more I would attempt it myself, but I don't have the depth of knowledge or the confidence.
- The coverage of the Germanic compass points is a bit inconsistent and has been for a while. It is a confusing topic because there are clearly several forms that presumably once had distinct meanings, but the meanings have shifted around quite a bit so it's hard to determine what meant what. I would definitely appreciate it if someone would offer to get together some editors and sort it all out! —CodeCat 20:54, 1 November 2014 (UTC)
This needs to be corrected or removed.
November 2014[edit]
good job!!!!!!!!!!!!!!!!!!!!!
Foreign word of the day: comprehendō[edit]
The 3rd definition makes no sense. How do I arrest or detain a place?
- Did you overlook the semicolon? It does not say arrest or detain a place, it says occupy, capture (of a place). Punctuation is important; it is there for a reason. —Stephen (Talk) 20:53, 1 November 2014 (UTC)
- I messed up the pipes. It's been fixed. — Ungoliant (falai) 21:21, 1 November 2014 (UTC)
Hi There is a mismatch for the entry in PGmc *snidaz. Surely the entry should be *snidą, to match the declension given.
- @Leasnam:, what do you think? —Aɴɢʀ (talk) 08:07, 3 November 2014 (UTC)
- Koebler gives the reconstruction a masculine gender (*snidaz), yet none of the attested descendants are masculine. Oftentimes a pgmc lemma will descend masculine in WGmc and oddly enough descend as neuter in Old Norse. And in such cases his reconstructs for pgmc are Masc. But in the case with this word, the OE shows neuter. I would say best to err on the safe side and agree with koebler: that pgmc was masc (*snidaz), but add a note on the entry explaining why, noting that masc descendants of this word either died out, were possibly changed (in the case of OE) due to influence from Ngmc, or were simply never recorded. Leasnam (talk) 16:21, 3 November 2014 (UTC)
Hola. Desde hace dos meses recibo comentarios en portugués, a pesar de que he señalado el español como el idioma en el que debo recibir la información. Soy traductora de inglés a español. Dolores Carreras Rosario
Dolores Carreras Rosario, Fémina, Español-Inglés, Traductora de inglés a español, Correctora de pruebas, vivo en San Juan, Puerto Rico.
Special:translators [edit]
Add translator English to Urdu Add translator English to Urdu Add translator English to Urdu Add translator English to Urdu Add translator English to Urdu
- Rather than repeating the same phrase several times, why don't you add translations into Urdu yourself? --Anatoli T. (обсудить/вклад) 12:25, 4 November 2014 (UTC)
Word of the day: mara[edit]
Hello! I think it would be very interesting if you added the connection of "mara" with " -mare" in nightMARE (english) and "merry" in nachtMERRY (dutch). Is there an ethymological relation? Thank you very much!
- It was already there. Renard Migrant (talk) 12:20, 6 November 2014 (UTC)
Dear Wiktionary I really appreciate your hard work. Whatever I may need is found here. You have helped me in everything and have saved my time. I donot know how can i thank you MAY GOD BLESS YOU, LIVE LONG THANKS VERY MUCH Yours Truly, Fiona Stacy Willton
So are you married and not been with your wife gor 26 years WOW
CHF Correct Writing?[edit]
Dear Sirs How do I correctly write this: CHF 120 or CHF 120.- or CHF 120.00
Thank you in advance for indicating the correct form.
- In an English-language context both "CHF 120" and "CHF 120.00" are correct. —Aɴɢʀ (talk) 20:00, 4 November 2014 (UTC)
Category:English words prefixed with post-[edit]
awsome place to look for words
- Glad to hear you found it useful ! And, Thank you for letting us know. It's always encouraging to know someone got something that helped them ! :)
please make a page in Bengali language. It is one of the most popular language in earth almost 240 million people can read and speak bengali
- I'm not sure I understand. If you mean a Bengali Wiktionary, it's bn:. If you mean a Bengali page for technical it would be bn:echnical but it doesn't exist yet. If you mean Bengali entries on the English Wiktionary, see Category:Bengali parts of speech. Renard Migrant (talk) 12:16, 6 November 2014 (UTC)
- The last two links should be bn:technical and Category:Bengali lemmas. —Aɴɢʀ (talk) 21:21, 6 November 2014 (UTC)
- We suffer of a shortage of Bengali editors. Would you like to become one? --Hekaheka (talk) 12:24, 8 November 2014 (UTC)
- The 't' on my keyboard is a bit broken, apologies! Renard Migrant (talk) 21:07, 15 November 2014 (UTC)
- We suffer of a shortage of Bengali editors. Would you like to become one? --Hekaheka (talk) 12:24, 8 November 2014 (UTC)
- The last two links should be bn:technical and Category:Bengali lemmas. —Aɴɢʀ (talk) 21:21, 6 November 2014 (UTC)
i didnt understand even one word
- Not even a and in? —Aɴɢʀ (talk) 13:57, 9 November 2014 (UTC)
- Some jerk in Singapore replaced the whole page with some kind of inventory data about 8 hours ago, but that was only there for about 13 minutes, so I'm not sure if that's what they're talking about. Chuck Entz (talk) 15:32, 9 November 2014 (UTC)
This is a wonderful website. Thank you for all your hard work. I know it is a work in process but an extremely valuable worldwide community resource. I often want to add information but do not understand the laws governing copyrights. I personally know so little and I don't want to violate someone's legal rights. Please know that your work is extremely important and will be a priceless legacy to all who follow you. Thank you. Milt Riggs.
- Thank you! If you want to add something and don't know how, post on my talk page at User_talk:Equinox and I may be able to help you with it. Equinox ◑ 02:11, 10 November 2014 (UTC)
Special:Search/Aran Economic Region[edit]
Aran economic region locate at central Azerbaijan.It has 2 million population about
i would like to see the obsolete definition of "religious" become more commonly recognized and used:)
- We don't have any control over that. We only record the words that people use; we don't encourage or discourage usage. —Stephen (Talk) 03:10, 11 November 2014 (UTC)
Special:Search खानदान[edit]
खानदान Its meaning and variations, please? Khandaq too. 22.214.171.124 07:31, 10 November 2014 (UTC)!
chock full[edit]
tjokvol (Flemish)
Did I misunderstand? CUID is it a medical problem affecting the body with poor longevity? I did not see this on this page.
In DEEP SONG, Federico Garcia Lorca writes:"The duende is a momentary burst of
inspiration,the blush of all that is truly alive,all that the performer is creating at a certain moment."
A fluid may be defied as a substance which is capable of flowing
- Isn't that what our definition says? Dbfirs 11:12, 14 November 2014 (UTC)
shit-eating grin[edit]
Thank you this helped a lot
I have always found the search engine easy to use until today when I visited and tried to search for an entry. It is horrible to navigate now and I could not understand the logic behind the change. A list of possible results used to be displayed in an easy to read format. I am not even sure what the current mishmash of information that is now displayed is.
Please review the decision to make a simple task rather awkward and ugly.
FED, FE[edit]
FED - front end developer
FE - front end
Thank you, Zvi Lanis <email redacted>
Wiktionary:Main Page[edit]
Shouldn't the IPA for Wiktionary have an "i" as the last sound instead of the I like milk? I love Wikipedia's use of IPA, especially compared to Google.
- That's the pronunciation of the person who created the logo, and it's not uncommon in at least parts of England. Chuck Entz (talk) 02:02, 14 November 2014 (UTC)
- Yes, it's quite common in the UK for the two "i" vowels to be pronounced the same (both as /ɪ/ as in city: /ˈsɪtɪ/), but /ˈwɪkʃən(ə)ri/ is also common in the UK. Dbfirs 11:09, 14 November 2014 (UTC)
Proprio che quello stavo cercando! Grazie.
circle jerk[edit]
Do women ever do this? Do women and men ever do it together? I don't know if there's a name for it. --220.127.116.11 23:44, 15 November 2014 (UTC)
Good web site[edit]
it is a good website but it doesn't have every meaning in my language Sinhalese. thank you.
- Thanks. Unfortunately we have no editors knowing who know Sinhalese and online resources are extremely poor. Why don't you help the project by adding some contents? You don't need to worry about transliteration, if you use templates. --Anatoli T. (обсудить/вклад) 03:00, 19 November 2014 (UTC)
Wiktionary:Main Page[edit]
The IPA of "Wiktionary" under the top left title is incorrect. That would be pronounced like "wik-shun-rih", where the R is rolled and the last vowel sounds like the first i. It should be "wɪkʃənɛɹi". —This unsigned comment was added by 18.104.22.168 (talk) at 23:28, 17 November 2014 (UTC).
- We seem to get this feedback every damn week. Can we just get rid of the stupid logo and replace it with an apple or something. Equinox ◑ 00:21, 18 November 2014 (UTC)
- This time the question was (presumably) asked by a Canadian student at the University of Colorado. I agree that it gets rather tiresome to have to answer the same question repeatedly (and to say that it's shown almost exactly as I pronounce it). One wonders why users cannot look up the word in Wiktionary to see the wide variety of ways in which it can be pronounced. Whether the r should be upside down is a matter of convention. It's common to see it transcribed as /r/ in English pronunciation guides but I assume that we have a policy to use /ɹ/. Dbfirs 02:12, 18 November 2014 (UTC)
- Why not replace it with the "Scrabble tiles" logo already available as an option under Preferences? —Aɴɢʀ (talk) 15:52, 18 November 2014 (UTC)
- I'm in favour. (And if it gets tiresome that the same feedback is given over and over again, well maybe that should be a hint that something needs to change.)
- Why not replace it with the "Scrabble tiles" logo already available as an option under Preferences? —Aɴɢʀ (talk) 15:52, 18 November 2014 (UTC)
- This time the question was (presumably) asked by a Canadian student at the University of Colorado. I agree that it gets rather tiresome to have to answer the same question repeatedly (and to say that it's shown almost exactly as I pronounce it). One wonders why users cannot look up the word in Wiktionary to see the wide variety of ways in which it can be pronounced. Whether the r should be upside down is a matter of convention. It's common to see it transcribed as /r/ in English pronunciation guides but I assume that we have a policy to use /ɹ/. Dbfirs 02:12, 18 November 2014 (UTC)
Correct and informative article. It might be added that the change from "Jóan" to "Jógvan" is Holtzmann's law. Another Faroese name with Holtzmann's law is "Rógvi" (Rói). Also, Jógvan is the most popular Faroese name by far.
Source: http://www.hagstova.fo/en/statbank/demographic-statistics/population-and-elections/names
The most popular Faroese last name "Joensen" correlates with Jógvansson and Jógvansdóttir, which the Danish priests wrote as Joensen in the end of 19th century.
Lookups Should Be Quicker, With Default Language[edit]
Wiktionary is a great service with great functionality. My biggest wish is for Wiktionary to allow users to set a default lookup language. For example, if I'm studying German and only interested in translations, I would like to type in "melden" and have the German entry come to the top of the screen--not the Dutch entry. I also would like to be able to set the site to go to the "best guess" match automatically, with suggestions for other entries at the top of the screen in case it is not the right entry.
In short Wiktionary is a great dictionary, but making lookups quicker would make it even better. —This unsigned comment was added by 22.214.171.124 (talk) at 00:25, 19 November 2014 (UTC).
- Other web dictionaries allow you to select from and to languages after you type the word and then display the appropriate information.
- Most of our users have no account, so settings aren't actually all that useful.
- It's also a problem that Wiktionary's layout needlessly wastes a lot of screen space. —This unsigned comment was added by 220.127.116.11 (talk) at 20:16, 19 November 2014 (UTC).
- If you have an account, try using the "Tabbed Languages" tool (at Special:Preferences under "Gadgets"). This divides the page so it only shows one language at a time, and it remembers which language you've looked at last so that the next time you visit a page, that language is displayed. So if you look at melden and select the German tab, then when you go to golden, you'll see German again automatically. Smurrayinchester (talk) 20:21, 19 November 2014 (UTC)
- And if not, you can enable it at Wiktionary:Preferences/V2. — Keφr 20:25, 19 November 2014 (UTC)
- If you have an account, try using the "Tabbed Languages" tool (at Special:Preferences under "Gadgets"). This divides the page so it only shows one language at a time, and it remembers which language you've looked at last so that the next time you visit a page, that language is displayed. So if you look at melden and select the German tab, then when you go to golden, you'll see German again automatically. Smurrayinchester (talk) 20:21, 19 November 2014 (UTC)
thank you
This is a Portuguese word, but I cannot find the definition here.
- Added. The most common uses are as an inflection of brecar and as part of the idioms com a breca and levar a breca. — Ungoliant (falai) 22:39, 19 November 2014 (UTC)
Thanks, your trouble is much appreciated!
Category:English words prefixed with semi-[edit]
this is incredible!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Category:Italian phrases[edit]
I love this Italian language ..thanks big up guys
Is the etymology of Old Norse píka known?
- I can't answer your question, but why do we have two almost identical definition lines in the entry? Dbfirs 18:22, 20 November 2014 (UTC)
dum dumi want list of voters current area subhashnagar south dumdum[edit]
screw the pooch[edit]
Hi Guys, this etymology seems to contradict itself.
The term was first documented in the early "Mercury" days of the US space program. It came there from a Yale graduate named John Rawlings who helped design the astronauts' space suits. The phrase is actually derived from an earlier, more vulgar and direct term which was slang for doing something very much the wrong way, as in "you are fucking the dog!" At Yale a friend of Rawlings', the radio DJ Jack May (a.k.a. "Candied Yam Jackson") amended this term to "screwing the pooch" which was simultaneously less vulgar and more pleasing to the ear.
The second sentence says John Rawlings coined the term and the last sentence says it was his friend DJ Jack May.
Thanks for all your good work!
For the Danish word, the IPA and the sound don't match.
Thank you for giving me the meaning of difficult words!
Hi, in reference to PGmc *habrô, the head word shows a weak masculine (or an-stem) in -ô, but the declension cited is a masculine a-stem in -az.For the sake of consistency, I suggest they should both refer to the same inflectional class, and any doubts about inflection be referenced in an added note.
- Thank you for bringing that to our attention. I have corrected the entry. It must have been an oversight. Leasnam (talk) 02:23, 24 November 2014 (UTC)
spring tide[edit]
The information is not sufficient.
- What more were you looking for? If you want encyclopedic information, see Wikipedia:Spring tide. —Stephen (Talk) 10:42, 24 November 2014 (UTC)
I can't read his mind of course, but at a first glance this is missing: pronunciation, etymology, oldest attested usage, citations, quotations and translations.
Fergusoning is new verb needed to picture what is happening right now in Ferguson USA. You can decide what it means, descripe and make it happen!
Respect all victims of law and unlawfulness
could someone ad this word to Wiktionary please.
Category:French words suffixed with -eau[edit]
This is brilliant, just one addition, the gender, would have been the icing on the cake
I cant find nothing about Droga , please help me to find something for that is important to me , cuzz i have to do a exam about this and i will be so thankful if you will help me.Tis is all i wanted to say
I see there are entries for both *kelþaz and *kelþą. The *kelþaz entry is straight forward, a neuter z-stem. The *kelþą entry is that of a neuter a-stem, but the suggested declension is *kelþaz (gen. *kilþiniz), the neuter z-stem. Is the *kelþą entry an older entry, superceded by the *kelþaz entry, or are there grounds to suggest that *kelþaz and *kelþą were in free variation and we are hedging our bets by suggesting both reconstructions?
Also, if *kelþą is withdrawn, its etymological data should be transferred to *kelþaz.
Although PGmc is not a language I know well, I am simply going through the lemma list checking for consistency. I strongly endorse the project of placing such a list online, and especially the need for promoting a standard orthography for PGmc, considering that each of the major authors 'freezes' their reconstruction at a different time period. Let's rally around Ringe. Dave crowley (talk) 23:59, 25 November 2014 (UTC)
- In Old English it could have been either, as the plural was cild , or cildru/cildra. Cognates in other languages, namely Old Swedish kolder arent much help either, but Germanic lexicon project gives *kilþiz / *kelþaz, a derivative of *kilþīn "womb" (--sorry for the -n; i dont have the ogonek n symbol on my android). It looks as though the two entries were created independent of each other by 2 separate editors. Leasnam (talk) 00:27, 26 November 2014 (UTC)
- The *kelþą entry was originally created as *keldaz, a z-stem...during the move the declension table was never updated. I have done so. I dont know if we need to keep both, but if the possibilty that this was two closely related words that coalesced into OE cild leaving traces of both in the plural i leave that to consensus to decide. Leasnam (talk) 00:51, 26 November 2014 (UTC)
- In Old English it could have been either, as the plural was cild , or cildru/cildra. Cognates in other languages, namely Old Swedish kolder arent much help either, but Germanic lexicon project gives *kilþiz / *kelþaz, a derivative of *kilþīn "womb" (--sorry for the -n; i dont have the ogonek n symbol on my android). It looks as though the two entries were created independent of each other by 2 separate editors. Leasnam (talk) 00:27, 26 November 2014 (UTC)
- If you haven't already, take a look at WT:AGEM to see what our current standards are for Pgmc entries. Chuck Entz (talk) 02:56, 26 November 2014 (UTC)
mind one's ps and qs[edit]
To whom it may concern, re: Mind one's P's and Q's. The real definition according to the Royal Navy. Rum rations on HMS ships are measured in pints and ale rations are measured in quarts for 1 each daily ration to ordinary seamen and other ratings and ranks. These two drinks were usually combined to make grog. Many sailors did not drink and traded their rations for food or favors to fellow sailors. Thus allowing other swabs to drink more. The more they drank the more tongues waged and usually the conversation strayed to this F'n officer or that. This caused the ships master at arms to warn drunk sailors to, "Mind your p's(pints) and q's(quarts).)
What was a barbecue called before it was called 'barbecue'?
- Well, grill goes back to the seventeenth century. Before that, in Middle English, it seems to have been called a broilour (according to the Middle English dictionary), which is related to the modern word broiler, or a rost iren (roasting iron). Smurrayinchester (talk) 08:39, 27 November 2014 (UTC)


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text:
Monday's edition of the San Francisco Chronicle has a breakdown of each of the Golden State Warriors' potential trade partners. Apparently, the only team that the Warriors have not been linked to is themselves. One of the curious rumors mentioned by the Chronicle is one with the Boston Celtics—a swapping of point guards Stephen Curry for Rajon Rondo. It is reported that the Dubs declined the notion of dealing away Curry.
read more
WARRIORS TRADE: Stephen Curry and Andris Biedrins CELTICS TRADE: Rajon Rondo The Golden State Warriors have reportedly offered anyone and everyone on their roster to the Orlando Magic in hopes of acquiring superstar center Dwight Ho... Read Post
Swirling trade rumors usually mean that the Golden State Warriors will find themselves on the short hand of acquiring a marquee potential franchise-changing player. This year, the Warriors, for lack of a better term, don't need any ... Read Post
NBA Trade Rumors Swirl, But What Moves Could Be In Store For Golden State After the Season? According to Rusty Simmons of the San Francisco Chronicle, if the Golden State Warriors cannot find the big man they are looking for at the ... Read Post


text:
Diners paying big bucks for dirt soup
POSTED: Tuesday, June 18, 2013 - 6:50am
UPDATED: Tuesday, June 18, 2013 - 7:17am
Tokyo, Japan (KTSM) — A new trend in high-end Japanese food is bringing customers closer to nature. An acclaimed chef in Japan is now known for his signature dish, "Soup of the Soil." It's made by chopping up burdock root, pan-frying it with dirt, then simmering and straining the resulting mixture. It's heated without any additional salt or seasoning. The idea is to give customers a true taste of the earth.
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Quotes & Info
|BPHX > SEC Filings for BPHX > Form 8-K on 27-Mar-2014
|All Recent SEC Filings
Results of Operations and Financial Condition, Financial Statements and
On March 27, 2014, BluePhoenix Solutions Ltd. (the "Registrant") posted an earnings release to the investor relations page of its website (www.bphx.com) announcing its results of operations for its fiscal quarter and full year ended December 31, 2013. A copy of the earnings release concerning the foregoing results is furnished herewith as Exhibit 99.1 and is incorporated herein by reference.
The Registrant is furnishing the information contained in this Report, including Exhibit 99.1, pursuant to Item 2.02 of Form 8-K promulgated by the Securities and Exchange Commission (the "SEC"). This information shall not be deemed to be "filed" with the SEC or incorporated by reference into any other filing with the SEC unless otherwise expressly stated in such filing. In addition, this Report and the press release contain statements intended as "forward-looking statements" that are subject to the cautionary statements about forward-looking statements set forth in the press release.
(d) Exhibits. Exhibit Number Description 99.1 Press Release, dated March 27, 2014, entitled "BluePhoenix Solutions Reports 2013 Fourth Quarter and Annual Financial Results"


text:
All branches of Marin County Free Library will be closed on Thursday, Nov 27 & Friday, Nov 28 for Thanksgiving.
Corte Madera Library will be closed for upgrades Nov 27 - Dec 15, reopening on Dec 16. More details.
It's Apple Harvest Time!
How about apple books at your library:
Who knew applesauce could be so cool? Check out this Applesauce Rap:
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417 Third Avenue Albany, Georgia 31701(229) 312-1000
2000 Palmyra Rd. Albany, Georgia 31701(229) 434-2000
126 Hwy. 280 West Americus, Georgia 31719(229) 924-6011
807 S. Isabella St. Sylvester, Georgia 31791(229) 776-6961
361 Randolph St. Cuthbert, Georgia 39840(229) 732-2181
FRIDAY, Jan. 3 (HealthDay News) -- Downhill skiing is a great way to enjoy winter, but you need to prepare your body beforehand to reduce the risk of injuries, an expert suggests.
"Most of us don't train before going on vacation, but it's important for skiers to work out because they tend to fall more when they are tired," Dr. David Lintner, chief of sports medicine at Houston Methodist Hospital, said in a hospital news release.
"Cardiac conditioning, leg strengthening and agility exercises are simple ways to increase endurance," he added.
Of the nearly 144,000 skiing injuries in the United States each year, the most common are a type of knee injury known as an anterior cruciate ligament (ACL) tear, and ulnar collateral ligament (UCL) tears, also known as skier's thumb.
To prevent ACL tears, start by jumping rope and then play basketball or tennis. That will strengthen the knee and familiarize the body with the motions of skiing, Lintner explained.
Skier's thumb happens when skiers fall on their hands while holding a ski pole awkwardly. It can't be prevented, but many companies have created safer equipment to help skiers protect their hands.
It's also important to properly prepare your ski equipment. This includes getting the bindings checked by an expert to ensure they are properly adjusted, Lintner said.
Skiers also need to pay attention to snow and sun conditions.
"Few shadows on a cloudy day make it hard to see the slope's contours and even harder to avoid the bumps that can lead to falls," Lintner said. "Also, check the snow conditions. If the snow is heavy and lumpy, check to see which slopes are groomed that day."
If you do suffer an injury while on a ski vacation, have it checked by a doctor before you return home, Lintner advised.
More information
The American Academy of Orthopaedic Surgeons has more about ski injury prevention.
SOURCE: Houston Methodist Hospital, news release
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Home Office – Townsend, MA
Marketing Assistant
contact us
Home Office – Townsend, MA
Marketing Assistant
We are currently seeking a highly-motivated individual to join our team of marketing and design professionals at our corporate office located northwest of Boston, in Townsend, MA. The ideal candidate is someone who is eager to learn and thrives in a fast-paced work environment. Strong decision-making and time management skills are needed. Having the ability to work independently as well as with others at all levels within the organization will be key to achieving successful results.
The position assists with a wide range of Marketing activities that include retailer reviews, merchandising strategies, new product launches, and product line management. This position is also directly responsible for tasks related to understanding the dynamics of the plastic housewares and storage industry. This is an outstanding opportunity for a recent college grad to gain Consumer Marketing experience and grow within the organization.
Specific Skills:
Strong attention to detail
Able to communicate effectively both verbally and written
Team player
Knowledge of Microsoft Office applications (Excel, Word, PowerPoint, Access)
Ability to focus, prioritize and manage multiple tasks
Bachelor's Degree – Marketing concentration, GPA 3.0+ strongly preferred; and 0 – 1 years of relevant experience. Microsoft Office experience needed. Travel, including air, may be required.
As member of the Sterilite team, you will enjoy a starting rate commensurate with your experience. This position entitles you to Sterilite's excellent benefit program that includes paid vacation time, health insurance, Health Savings Account (HSA), dental, vision and life and AD&D insurance, short-term disability, 401(k) retirement plan with a match, product discounts, and educational reimbursements.
Select here to apply on-line
Or to apply via e-mail, send a resume and salary requirements to:
No phone calls please. Local candidates only. There is no relocation assistance offered for this position.
Sterilite Corporation is an Equal Opportunity Employer.
Home Office – Townsend, MA
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Way to the Dawn
Edit Page Last Edit: 1 year ago
Riku has used more than one Keyblade in his time. He has used Soul Eater, Keyblade of People's Heart, Oblivion, and even the Kingdom Key. However, his main and more recent Keyblade is an evolved form of the Soul Eater known as Way to the Dawn. It represents both Light and Dark.
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Christian Bale
Christian Bale Admits Wanting To Play Batman Again
What could have been...
Ben Affleck Better Batman Than Christian Bale Because He's American?
Affleck vs. Bale. Here we go...
Watch A New Behind-The-Scenes Exodus: Gods And Kings Featurette
Ridley Scott talks about production and more.
8 More Exodus: Gods and Kings High-Res Images
Christian Bale, Ben Kingsley and more.
New Behind-The-Scenes Look At Exodus: Gods and Kings
Stars Christian Bale directed by Ridley Scott.
New High-Res Christian Bale Exodus Image
Bale stars as Moses.
32 The Dark Knight Set Photos With Heath Ledger
With commentary from director Christopher Nolan.
Comic-Con Dark Knight LEGO Set Revealed
First time Heath Ledger Joker is in LEGO form.
Exodus: Gods And Kings (2014) Trailer Now Online; Stars Christian Bale
Ridley Scott's epic tale hits this December.
Three New Posters For Ridley Scott's Exodus; Stars Christian Bale
Bale as Moses, and Edgerton as Rhamses.


text:
No deal for Thunder's Scott Brooks
While the focus as of Sunday will be on free-agent NBA players, the Oklahoma City Thunder are still hoping to keep their coach, Scott Brooks, from entering the same waters.
As of Friday, the only certainty is that for the tale of the Thunder's feel-good rise to continue, general manager Sam Presti and agent Warren LeGarie have to find a middle ground. Soon.
"We're not close," a source familiar with the negotiations said, "and the clock is ticking."
It's a sign of the times that the Thunder and Brooks have not been able to work out an extension, considering how much success they've had together. Since Brooks succeeded P.J. Carlesimo after a 1-12 start to the former Seattle franchise's first season (2008-09) in Oklahoma City, the Thunder's trajectory has been nothing but skyward. In his first full season as coach, they qualified for the 2010 playoffs. The next season, they reached the 2011 Western Conference finals. Now, of course, they're coming off a trip to the Finals, where they lost to the Miami Heat in five games.
The crux of the problem is that Brooks, based on the team's accomplishments, has been vastly underpaid the past two seasons, making $1.9 million and $2.1 million, respectively. The Thunder originally offered him a three-year extension worth between $11 million and $12 million before this past season. In light of this year's success, they increased the offer to roughly four years for $16 million.
Those figures are in line with the NBA's new economic model, where championship-winning Heat coach Erik Spoelstra made $3 million this year, according to sources, and last year's championship-winning coach, Rick Carlisle of the Mavericks, signed an extension that netted him only a $100,000 raise -- from $4.5 million to $4.6 million -- in the first year of his new deal.
While Presti and LeGarie both declined to comment on the negotiations, the Thunder's view seems to be they are giving Brooks a hefty raise and, based on the latest deals -- including the Bulls keeping Tom Thibodeau in the $2 million range by exercising a one-year option despite Chicago posting the East's best record the past two seasons -- are paying him top dollar. Randy Wittman, recently named head coach of the Washington Wizards, is making less than $2 million. LeGarie, of course, can counter that Brooks maneuvered the coltish Thunder past both Carlisle and Spurs coach Gregg Popovich, who is believed to be making close to $6 million a year.
The decision facing the Thunder is putting a price on Brooks' importance in the continued growth and development of the team's impressive collection of young talent, led by Kevin Durant and Russell Westbrook. For Brooks, it's weighing the value of coaching that championship-caliber talent against possibly starting over with the rebuilding Portland Trail Blazers, who plan to pursue Brooks if he's available. LeGarie also represents the Blazers' new GM, Neil Olshey.
Ric BucherNBA Reporter, ESPN The Magazine Senior Writer
- Senior writer for ESPN The Magazine
- Co-authored "Yao: A Life in Two Worlds"
- Full-time beat writer/NBA analyst since 1992
- LeBron, Cavs get back to .500 with Wiz rout
- Wall: Always going to be rivals with Irving, Rose
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Baxter Holmes »
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- Haberstroh: Dallas is Lob City | CP3 talks lobs
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- Doolittle: Can the Raptors sustain success?
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- Ford: Top 30 NBA prospects | Stock watch


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Latest Issue
Latest Issue
PharmTech Europe
|Email Newsletters from Pharmaceutical Technology and Pharmaceutical Technology Europe
Providing the latest business, scientific, and regulatory news for the pharmaceutical and biotech industries.
News from Europe's pharmaceutical manufacturing industry coupled with upcoming events, and exclusive articles and interviews from industry experts.
Investigating the Influence of Glycosylation on Protein Conformation and Dynamics
Structure and structural dynamics are important attributes that enable proteins to perform many different activities in vivo. Although most of the unique structural and functional properties of a protein are dictated by its amino-acid sequence, there are many changes, called post–transitional modifications (PTMs) that can alter a protein as it is expressed, folds, and ages (1). These alterations can significantly change and control the specificity and strength of protein interactions, as well as influence the physico–chemical properties of the protein (e.g., stability, solubility, immunogenicity) (2). Probably one of the most common and important of these PTMs is glycosylation—the attachment of oligosaccharides to proteins.
During recent years, it has become increasingly apparent that glycosylation is important in controlling the function and solution behavior of proteins in solution (3, 4). More than half of all eukaryotic proteins are glycoproteins (5). The oligosaccharides, also referred to as glycans or carbohydrates, commonly found on a protein exist as either N–linked or O–linked oligosaccharides and typically consist of 2 to 14 monosaccharides chemically linked in a linear or branched configuration. N–linked oligosaccharides are chemically linked to asparagines (and to a lesser extent arginine) within the consensus sequence –Asn–Xaa–Ser/Thr (6), while O–linked oligosaccharides are chemically linked to any serine or threonine (7).
To date, most of the progress in characterizing the carbohydrates on glycoproteins has focused on studying their structure and composition. These results have shown that a diversity of oligosaccharide structures can exist at any given glycosylation site on a protein. This diversity is one of the major causes of the microheterogeneity observed in proteins and is one of the major challenges biopharmaceutical companies face in demonstrating lot–to–lot comparability in manufacturing a glycosylated protein biopharmaceutical. Differential glycosylation on proteins will also be an important factor in determining similarity between innovator products and their follow–ons.
Brief history of H/DX–MS
Hydrogen exchange (HX) is a phenomenon that was identified in the 1950s by Hvidt and Linderstrom–Lang (13) and was used in developing the technique of hydrogen/deuterium exchange (H/DX). Later developments in H/DX coupled this technology with various spectroscopic techniques, which included NMR and FTIR to help better study and understand protein structure (14, 15). The eventual coupling of H/DX to MS (H/DX–MS) came in 1991 through the work of Katta et al. (16) and was further enhanced by the work of Zhongqi Zhang and David L. Smith while they were at Purdue University. They paired H/DX–MS experiments with proteolytic digestion (17). This latter union provides localized information concerning the relative amount and rate of H/DX in different parts of a protein. Such H/DX information can achieve peptide resolution as low as 5–10 amino–acid residues with nearly complete sequence coverage. H/DX–MS also has low sample requirements (down to a few picomoles) and can be performed in native or formulated buffer conditions. In addition, more recent advances in terms of both hardware and software now enable H/DX–MS experiments to be completed in a few days or less (12). As a result of these developments H/DX–MS has steadily gained in popularity as a technique for studying the higher–order structure of proteins.
The basics of H/DX–MS
The mechanisms of HX have been reviewed before in detail (18, 19). Briefly, HX occurs in a protein when labile hydrogen atoms change places with hydrogen atoms in solution. If an H2O solution is replaced with D2O (that is with deuterium instead of hydrogen), the labile hydrogen atoms in the protein will switch with deuterium atoms. In proteins, there are several different types of hydrogen atoms (e.g., aliphatic, hydroxyl, etc.), however, only the backbone amide hydrogen atoms exchange within a timeframe that can be monitored in a typical H/DX–MS experiment. Because every amino acid has a backbone amide (except for proline), these hydrogens act as sensors for monitoring the local conformational environment of the protein backbone (18). H/DX information can provide significant indirect insight into the conformational status of the protein polypeptide backbone. This information is especially informative in comparison studies of protein variants (19, 20).
The insertion of a digestion step just after quenching (17), but prior to LC–MS (see Figure 2) cuts the protein into smaller pieces (peptides). During the digestion step, quench conditions must be maintained to preserve the deuterium label; therefore an acid protease (usually pepsin) is used for proteolytic digestion. After digestion, the peptic peptides are separated by reversed phase LC, and the mass of each peptide is measured by the mass spectrometer. Both digestion and chromatographic separation steps are carried out on–line. The reversed phase chromatography step not only functions to separate peptides, it also serves the important function of removing buffer salts and other excipients not compatible with MS.
Following the chromatographic separation, the peptides are analyzed by mass spectrometry, and the amount and location of the deuterium are determined (electrospray is most commonly used, although MALDI has also been used (21)). Typically, the protein and amino-acid sequence are known, and the resulting pepsin peptides are unambiguously identified by tandem MS. The solvent used in the digestion and chromatography steps are pure (100%) H2 O. As a result, deuterium that was incorporated in the protein starts to exchange back to hydrogen during these steps. To minimize this, and to supply enough time for analysis, the temperature of the quench, digestion, and separation steps is dropped, and the chromatography is done as quickly as possible under acidic pH conditions. At 0 °C and pH 2.5–2.6, in a properly controlled experiment, only about 20%–30% of the deuterium is lost during analysis. If desired, control experiments can be performed to correct for this loss (17).
Using the deuterium uptake information, a comparison study can be conducted on a protein and its variant forms (i.e., a protein with and without different oligosaccharides). The main feature monitored in such comparisons is the difference in the locations and extent of deuterium incorporation as a function of time. These results provide indirect information concerning conformational changes in the polypeptide backbone of a protein as a result of a PTM. We have noted that protein deglycosylation can result in greater deuterium incorporation in some areas, and less in others.
Effect of deglycosylation on the conformation of an IgG1 antibody
Recombinant monoclonal antibodies (rmAb) are an important class of biopharmaceutical proteins. Antibodies are used to treat a wide array of medical conditions from autoimmune diseases to cancer to various other diseases (22). Today, more antibodies are in biopharmaceutical development pipelines and in clinical programs then are any other class of protein (23). The most common therapeutic rmAb is the immunoglobulin gamma 1 (IgG1). The IgG1 is made up of two identical subunits, a so–called homodimer. It is also a glycosylated protein with an apparent molecular weight approaching 150 kDa. An IgG1 is composed of two identical heavy chains and two identical light chains that are covalently connected by disulfide bonds. On each heavy chain (typically on residue Asn298), there is a single N–linked biantennary type oligosaccharide (6, 24). For IgG1 antibodies, glycosylation is a major source of heterogeneity, as most antibody expression systems (such as Chinese Hamster Ovary cells (25)) are incapable of producing an antibody containing a glycan with a uniform structural composition. Changes in IgG1 glycosylation (i.e., different levels of sialic acid, galactose, fucose, high mannose structures) have been shown to induce thermal destabilization, influence effector function, drug clearance, and may also provoke an immunogenic response (3, 26). Therefore, understanding the impact that glycans have on the conformation of an IgG1 (or any other glycosylated protein) is very important.
Effect of fucosylation and galactosylation on the conformation of an IgG1 antibody
In another experiment, a subtle change to the IgG1 glycan was made, and the conformation and dynamics of the IgG1 were investigated using H/DX–MS. IgG1 samples were compared in various combinations with and without galactose and fucose (27). Previous published work reported that decreased levels of fucose and increased levels of galactose increase effector function responses, and that these effects appear to be additive (27–28, 32). It was also shown that neither fucose nor galactose is directly involved in Fc receptor interactions (29, 33). If this is indeed the case, how is it that the addition of galactose or subtraction of fucose affects the effector functionality? Experiments using H/DX–MS showed that the deuterium incorporation into the IgG1 backbone with or without fucose was essentially the same, indicating no difference in the conformation of the IgG1 backbone. The fact that no change in H/DX–MS was seen when comparing the IgG1 with and without fucose indicates that the change in protein conformation may involve the repositioning of amino-acid side chains, which cannot be detected by H/DX–MS. It is also possible that segments of the protein's polypeptide backbone are repositioned to an environment that does not directly affect the solvent exposure of the backbone amide. In H/DX–MS experiments comparing IgG1 with and without galactose, the only difference that could be detected involved the reduction in deuterium incorporation in the IgG1 Fc heavy chain at residues 240–250 when galactose was present. The direct involvement of these IgG1 Fc residues with Fc receptors has been shown to be unimportant (27). These findings coupled with X–ray crystallography data that indicate that the Fc glycans form several contacts with a number of amino acids on the IgG1 Fc (29) are puzzling.
To better understand these data, H/DX MS binding experiments were performed to investigate the interaction between an Fc receptor, FcγRIIIa, and two IgG1 variants (27). In this work, an IgG1 with no fucose and complete galactosylation was found to interact differently with FcγRIIIa relative to the native IgG1, which contained fucose and very little galactose (~15%). While no direct evidence emerged to explain the molecular details on how galactose and fucose influence effector function, these data suggest that a change to the IgG1 backbone conformation important for Fc functionality may not have occurred. In the case of fucose, its presence may sterically interfere with optimal conformational changes required for the IgG1 Fc to bind the Fc receptor with maximum interactions, leading to significantly weaker binding. Conversely, the presence of galactose may interact with various amino–acid side chains on the IgG1 Fc to better facilitate a necessary conformational change that maximize IgG1 Fc interaction with Fc effector proteins. As a result, the absence of fucose or the presence of galactose may promote conformational flexibility within specific regions of the IgG1, which are favorable for effector function interactions. Such information should be of interest to those involved in engineering Fc–specific effector activity, as this information provides insights important for developing detailed models in explaining how carbohydrate–protein structure facilitates IgG1–effector function.
Early glycoprotein research has pointed to a general reduction in dynamic motion and increased thermal stability of a protein with its coupling to a carbohydrate (34). However, details at the molecular level on how protein dynamics and stability arise as a result of carbohydrate–protein interaction are not clear. X–ray crystallography is not always possible when a protein is flexible and/or modified by an oligosaccharide. In addition, the view of the unique conformation captured in a crystal may not be representative of those found in solution. In the case of NMR, the generally low sensitivity and potentially large sources of overlapping signals, put restrictions on the size of the protein that can reasonably be studied. In addition, the need to label proteins (usually using 15 N or 13 C) significantly limits routine sample analysis and throughput, which limits the widespread application of NMR.
H/DX–MS is a sensitive solution–based technique that offers spatial resolution to a few amino-acid residues, typically 5–10. In fact, recent developments using electron transfer disassociation (ETD) offers an opportunity for H/DX–MS to reach single–residue resolution with nearly complete sequence coverage (35). Given these attributes and those mentioned earlier in this report, H/DX–MS is capable of providing useful information to answer many questions in the biopharmaceutical industry related to the higher order structure of biopharmaceuticals. This capability was briefly demonstrated in this report by the ability to conduct an array of comparability studies to reveal the impact of different oligosaccharides on the protein structure of an IgG1. Such capabilities are useful to researchers responsible for designing new protein biopharmaceuticals, as well as those in biopharmaceutical process development responsible for delivering a stable and consistent commercial drug product. As a result, H/DX–MS should see a growing interest from a wide spectrum of biopharmaceutical scientists.
The authors would like to thank Dr. Helena Madden, Dr. Rohin Mhatre, and Dr. John R. Engen for helpful discussions and for critical reading of the manuscript.
Damian Houde* is a scientist, and Steven A. Berkowitz, is a principal investigator, both at Biogen Idec, Inc., 14 Cambridge Center, Cambridge, MA 02142, tel: 617.914.5841, fax: 617.679.3476.
*To whom all correspondence should be addressed.
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Just wondering several things as we prepare for our trip to Ghana in March:
1) Is the milk safe to drink in restaurants and what you purchase in the store? I imagine it's not pasturized? Anything in particular (food/drink/water wise) that we must stay away from?
2) What would be good things to bring for the locals? I've come across some very reasonably priced reading glasses in varying strengths - would they have use for that there? Perhaps there would be a Dr I could leave them with? Unique, useful ideas most appreciated.
3) Will all the hotels/guest houses etc we stay in provide mosquito netting? Do you ever bring your own?
4) Tell me what items you take with you when specifically going to Ghana that you may not need elsewhere.
5) Do you ever use the ATM machines? Do you ever use your credit card and if so where? Do you travel with travellers cheques and how hard is it to get them cashed?
Thanks so much!
Guenmai - Help with trip to Ghana
Just wondering several things as we prepare for our trip to Ghana in March:
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CD could not find MSVCR90.dll
My XP computer keeps coming up with this issue (image attatched). It asks for the library MSVCR90.dll which weirdly it then relates to office 2010. I am quite clueless and really need the cd to work. I have used it on a few computers with different verisions and with office and still the problem is here. Any ideas-please you would save my life . By the way: my windows 7 (out of use at the moment) used to just not open it so I assume the same problem although it stated no problem
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There are rumors floating around that new WWE diva Eva Marie has posed nude before, and that has caused thousands of wrestling fans to scour the internet in search of such naked images. However, it turns out that the confusion stems from the fact that Playboy model Eva Hilovski uses the same name on occasions.
Independent wrestler Reby Sky, who recently got married to former WWE star Matt Hardy, is currently doing another photo shoot for Playboy. Her first nude pictorial for the magazine was back in 2007.
With all of her prior backstage issues, there are those that believe that Rosa Mendes might have been a good candidate to generate interest in Total Divas, but it appears that WWE did not consider that possibility very seriously at all. Officials opted to go with Summer Rae as the new cast member.
Rosa Mendes posted a picture on Twitter of herself and Alicia Fox wearing cheerleader outfits while backstage at a WWE event.
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There are many within WWE that believe that Rosa Mendes might have fabricated the domestic abuse story involving she and then boyfriend Jackson Andrews, a former developmental wrestler for the company. Many started doubting her because of her antics on the road.


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bioethanolLine breaks: bio|etha¦nol
Pronunciation: /ˌbʌɪəʊˈɛθənɒl /
Definition of bioethanol in English:
noun[mass noun]
Ethanol produced from plants such as sugar cane or maize, used as an alternative to petrol.
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- With all the advantages stated above, the use of bioethanol seems more pressing.
- Elsewhere there's excitable talk of hydrogen, bioethanol, fuel cells, hybrids.
- The perfect burning is due to octane number bioethanol is higher than gasoline.
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Word of the day sacerdotal
Pronunciation: ˌsasərˈdōtl
relating to priests or the priesthood; priestly


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The Orlando Sentinel is reporting that Teri Garr will be appearing at a screening of "Close Encounters of the Third Kind" on Tuesday, October 23, 2007 at the Cinemark at Festival Bay in Orlando, Florida. Garr starred in the movie, which opened in theaters on November 16, 1977.
Garr will reflect on her life, acting career, and quest for fitness and wellness while facing MS during the humorous, touching hour-long Q&A. Following the event, attendees are invited to remain in the theatre to enjoy a special 30th anniversary 35mm screening of the Stephen Spielberg classic "Close Encounters of the Third Kind."
Click the Read link below to read the full article.
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text:
Belkin Thunderbolt Dock review
Add ports to your Thunderbolt Mac
- Product Type
- Docking Station
- Total Number of USB Ports
- 3
- Connectivity Technology
- Wired
- Brand Name
- Belkin
- Device Supported
- Notebook/Desktop PC
- Network (RJ-45)
- Yes
- Colour
- Silver
- Manufacturer
- Belkin International, Inc
- Product Name
- Thunderbolt Express Dock
- Manufacturer Part Number
- Manufacturer Website Address
- http://www.belkin.com/uk
- Marketing Information
Thunderbolt is a quantum leap forward. Suddenly everything is faster, easier, better. Thunderbolt moves data on two bidirectional 10Gbps channels. That's 20 times faster than USB 2.0, 12 times faster than Firewire 800. And it means an entire
With Thunderbolt™ Express Dock, all your drives, networking, input and output devices connect to the 8 ports on the back. It in turn connects to your laptop through 1 Thunderbolt port. In short, eight cables become one cable.
So taking your laptop when you go, and bringing it home when you return means dealing with a single cable. Which connects you to a very brave new world indeed.
We thought that a technology as brilliant and beautiful as Thunderbolt deserved a dock that not only performs at the highest level, but looks the part as well. So we designed The Thunderbolt™ Express Dock with an elegant, low profile. Simple is beautiful, and Thunderbolt™ Express Dock is a shining example.
- Host Interface
- Thunderbolt


text:
Residents for Off-leash Milwaukee Parks (ROMP) and the Milwaukee County Park System are pleased to announce the season's final "Doggie Dip" to be held at Cool Waters Aquatic Park after the pool is closed to public swimming for the season. A presale of admission passes will be offered during open hours at Cool Waters the day before on Sunday, Sept. 6 from 10am-6pm.
Schedule of "Cool Waters" Doggie Dip
Monday. Sept. 7 ……Cool Waters……………2028 S. 124th Street……………6:30-8pm
"Romp is so pleased to partner with the Milwaukee County Parks System again to offer the Doggy Dips. These events have been great fundraisers for us in the past and the best part is watching the pure joy each of the dogs experience at these fun events. That's worth the admission price alone," said dog park President, Kevin Frank.
Admission is $5.00 per dog. Bring Rover for a swim at Cool Waters. For more information about ROMP and the Doggy Dip, visit milwaukeedogparks.org, email firstname.lastname@example.com or call (414) 769-8806.
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Third overall pick still has not agreed to deal with Dolphins. Terry McCormick
Dion Jordan, the third overall pick in the 2013 NFL Draft, still hasn't signed his contract as Miami Dolphins players are scheduled to report on Saturday.
But the defensive end is confident he will not be a holdout.
"It's not finalized yet, but I'll be there," he told the Miami Herald.
With time running short, there will have to be some serious negotiating done in order to prevent Jordan from being the third straight Dolphins first-rounder to miss time at the start of camp.
The problem in Jordan's deal, as it is for many of the unsigned picks at the top of the draft, is offset language, which protects the drafting club monetarily should a player be let go before the end of his rookie contract and sign with another club.
Follow me on Twitter @TerryMc13
Terry McCormick covers the Titans for TitanInsider.com
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