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Blaine Elementary
2014 LCHS Bulldogs
East Elementary
West Elementary
Louisa Middle
Lawrence County High School
Jacob Osborne, Cole McCreary, Jacob West, Ben Mattingly, Laken Fitch, Abby Haynes (Absent: Ashleigh Adkins and Warren Price) LCHS Kentucky Governor's Scholars
LCHS Lady Bulldogs Soccer
BES Girls Basketball
LMS Girls BasketBall courtesy of John Nolan Photagraphy
It's all about the finishing touches!
All Lawrence County Schools will operate on a 2 hour delay Wednesday, November 19, 2014. Buses will run on clear roads only.
Phone: 6066389671
Fax: 6066380128
Email: firstname.lastname@example.com
50 Bulldog Lane
Louisa KY 41230


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10 results for "rodgers"
Keep USC Trojans class of 2013 in perspectiveGreg Katz
USC's recruiting class certainly took some hits on signing day, but let's not lose sight of the players who did elect to become Trojans.Story | Conversation | February 06, 2013
A look at how USC Trojans Class of 2013 recruits fitJohnny Curren
A look at how USC's recruiting class, from early enrollees to uncommitted prospects, might fit on the Trojans.Story | Conversation | February 04, 2013
USC Trojans' targets go quiet before signing dayBlair Angulo
With several USC recruits and targets having gone quiet before signing day, it's hard to tell if that's a good or bad sign for the Trojans.Story | Conversation | January 31, 2013
USC Trojans recruits Kenny Bigelow Khaliel Rodgers ready to playBlair Angulo
DL Kenny Bigelow and OL Khaliel Rodgers saw their senior seasons cut short, so they can't wait to get to USC and help the Trojans on the field.Story | Conversation | November 20, 2012
Three commits mark first USC Trojans camp weekendGarry Paskwietz
Commits from 2013 wide receiver Steven Mitchell and 2014 linemen Jordan Poland and Toa Lobendahn marked USC's first camp weekend and also altered the Trojans' recruiting landscape going forward.Story | Conversation | June 11, 2012
How the USC Trojans might build 2013 recruiting classErik McKinney
With four commits in the fold, here's a look at where the Trojans will go from here in the 2013 recruiting class.Story | Conversation | April 23, 2012
Kenny Bigelow, David Sills enjoy visit to USC TrojansErik McKinney
Elkton, Md., teammates Kenny Bigelow and Davis Stills attended Saturday's spring game and were able to get a glimpse at their futures with USC.Story | Conversation | April 17, 2012
What to watch for USC Trojans in 2013 recruitingErik McKinney
There's no rest for the weary, as the USC coaching staff rolls onto the 2013 class. This is what, and who, it'll be looking for.Story | Conversation | February 06, 2012
USC Trojans commits Kenny Bigelow and David Sills V part of close...Erik McKinney
Kenny Bigelow, a junior defensive tackle that committed to USC last week, and freshman quarterback commit David Sills V lead a cohesive six-pack of elite prospects at Bear (Del.) Red Lion Academy.Story | Conversation | December 04, 2011
Steve Bisheff on George Farmer, Al Davis and Aaron RodgersSteve Bisheff
Steve Bisheff looks forward to seeing George Farmer at running back and remembers Al Davis.Story | Conversation | October 12, 2011

subset: commoncrawl


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Arizona Wildcats
Updated Jun 18, 2013 - 10:02 am
Wildcats boast easiest non-conference football schedule
If the Arizona Wildcats struggle to win games in 2013, it probably won't be due to their out of conference slate.
According to CBS Sports' Bruce Feldman, Rich Rodriguez's team has the softest non-conference schedule in the land.
Year Two of the Rich Rod Era sees the Wildcats face two of their three non-conference opponents coming off eight-win seasons, but it's FCS Northern Arizona and Texas-San Antonio, which lost its other four games by at least 20. Arizona's other non-con game is on the road but it's at UNLV, which was 2-11 last season.
Last season, Arizona's non-conference schedule included Toledo, Oklahoma State and South Carolina State -- all at home, with Arizona winning all three games. Including Pac-12 play they faced five top-25 teams, and they went 2-3 in those contests.
Along with their three non-conference games, the Wildcats will also square off with Pac-12 foes Utah, UCLA, Washington State and Oregon at home, along with Washington, USC, Colorado, California and Arizona State on the road.
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Wildcats Audio
- Vince Marotta's Territorial Cup PoemVince revisits his tradition of writing a poem regarding the Duel in the Desert.
- Bickley BlastUCLA's chances for a national championship may be slim, but their hopes are still alive.
- Jeff Van Raaphorst-Former ASU quarterback Jeff Van Raaphorst believes that rivalry games affect fans more than they do players.
- Mark May, ESPN college football analyst ESPN college football analyst Mark May says this is the biggest Territorial Cup game he can remember
- Greg Byrne, University of Arizona athletic directorGreg Byrne says he thinks the Territorial Cup matchup will be good for college sports in Arizona.


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Apple recently updated the iPhone and two iLife '08 applications, fixing mostly unspecified bugs. iPhone 1.0.2 offers no details as to what's changed other than "bug fixes" and, like all iPhone updates, is available only through iTunes. iMovie 7.0.1, available both via Software Update and as a standalone download, not only offers unknown fixes, but also solves an issue with publishing movies to .Mac Web galleries; the updater is a 9 MB download. Speaking of publishing Web sites, iWeb 2.0.1 (a 12 MB download) tackles problems when upgrading and publishing sites created using iWeb 1.x.
Opening a Folder from the Dock
Sick of the dock on Mac OS X Leopard not being able to open folders with a simple click, like sanity demands and like it used to be in Tiger? You can, of course click it, and then click again on Open in Finder, but that's twice as many clicks as it used to be. (And while you're at it, Control-click the folder, and choose both Display as Folder and View Content as List from the contextual menu. Once you have the content displaying as a list, there's an Open command right there, but that requires Control-clicking and choosing a menu item.) The closest you can get to opening a docked folder with a single click is Command-click, which opens its enclosing folder. However, if you instead put a file from the docked folder in the Dock, and Command-click that file, you'll see the folder you want. Of course, if you forget to press Command when clicking, you'll open the file, which may be even more annoying.
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Your life is digital; back it up! <http://tid.bl.it/code42-tb>


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Born in Youngstown, Ohio and raised Italian American and Catholic. My father was involved in a family business and my mother was/is an elementary school teacher. As a family, we moved back and forth between northeast Ohio and South Florida throughout my childhood. Started playing contact football at age 9 in Florida and wrestling at age 13 in Ohio. My senior year of high school I placed second in the Florida AAA State Tournament and went on to college at Pennsylvania State University where I wrestled in 1991-1992 and tutored student athletes. Moved to Philadelphia, Pennsylvania in 1995 with my bachelors degree in criminal justice. Began work counseling adjudicated teens and children with mental health issues. Started teaching special education in the Philadelphia School District in 1998. Received my masters in Special Education in 2001 from Cabrini College and continued to teach in both public school and residential school settings. Started stand up comedy in 2000 and moved to New York City in 2003. Was the 1983 and 1984 Spelling Bee runner up at Pine Grove Elementary School. I failed to advance to the national bee in Washington D.C. because of the complexity of the word roothless, which I still spell with two o's.
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Ivory Silk Print Panel Blouse
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This sumptuous silk Raoul blouse is updated with a crosshatch print front panel, lending a modern edge to a elegant and classic piece.
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Nuria Tamayo
Article: Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists.[Show abstract] [Hide abstract]
ABSTRACT: Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system. TRPM8 is the predominant mammalian cold temperature thermosensor and is activated by cold temperatures ranging from 8-25 °C and cooling compounds such as menthol or icilin. TRPM8 antagonists are being pursued as potential therapeutics for treatment of pain and bladder disorders. This manuscript outlines new developments in the SAR of a lead series of 1,2,3,4-tetrahydroisoquinoline derivatives with emphasis on strategies to improve pharmacokinetic properties and potency. Selected compounds were profiled in two TRPM8 target-specific in vivo coverage models in rats (the icilin-induced wet dog shake model and the cold pressor test). Compound 45 demonstrated robust efficacy in both pharmacodynamic models with ED90 values <3 mg/kg.Journal of Medicinal Chemistry 03/2014; · 5.61 Impact Factor
Article: Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles.[Show abstract] [Hide abstract]
ABSTRACT: In the previous report , we described the discovery and optimization of novel small molecule disruptors of the GK-GKRP interaction culminating in the identification of 1 (AMG-1694). Although this analogue possessed excellent in vitro potency and was a useful tool compound in initial proof-of-concept experiments, high metabolic turnover limited its advancement. Guided by a combination of metabolite identification and structure-based design, we have successfully discovered a potent and metabolically stable GK-GKRP disruptor (27, AMG-3969). When administered to db/db mice, this compound demonstrated a robust pharmacodynamic response (GK translocation) as well as statistically significant dose-dependent reductions in fed blood glucose levels.Journal of Medicinal Chemistry 01/2014; · 5.61 Impact Factor
Article: Correction to Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511.Journal of Medicinal Chemistry 10/2012; 55(20):8975. · 5.61 Impact Factor
Article: Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511.[Show abstract] [Hide abstract]
ABSTRACT: The phosphoinositide 3-kinase family catalyzes the phosphorylation of phosphatidylinositol-4,5-diphosphate to phosphatidylinositol-3,4,5-triphosphate, a secondary messenger which plays a critical role in important cellular functions such as metabolism, cell growth, and cell survival. Our efforts to identify potent, efficacious, and orally available phosphatidylinositol 3-kinase (PI3K) inhibitors as potential cancer therapeutics have resulted in the discovery of 4-(2-((6-methoxypyridin-3-yl)amino)-5-((4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine (1). In this paper, we describe the optimization of compound 1, which led to the design and synthesis of pyridyltriazine 31, a potent pan inhibitor of class I PI3Ks with a superior pharmacokinetic profile. Compound 31 was shown to potently block the targeted PI3K pathway in a mouse liver pharmacodynamic model and inhibit tumor growth in a U87 malignant glioma glioblastoma xenograft model. On the basis of its excellent in vivo efficacy and pharmacokinetic profile, compound 31 was selected for further evaluation as a clinical candidate and was designated AMG 511.Journal of Medicinal Chemistry 08/2012; 55(17):7796-816. · 5.61 Impact Factor
Article: Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.[Show abstract] [Hide abstract]
ABSTRACT: A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-based approach was used to improve potency and selectivity, resulting in the identification of 54 as a potent inhibitor of the class I PI3Ks with excellent selectivity over mTOR, related phosphatidylinositol kinases, and a broad panel of protein kinases. Compound 54 demonstrated a robust PD-PK relationship inhibiting the PI3K/Akt pathway in vivo in a mouse model, and it potently inhibited tumor growth in a U-87 MG xenograft model with an activated PI3K/Akt pathway.Journal of Medicinal Chemistry 05/2012; 55(11):5188-219. · 5.61 Impact Factor
Article: Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.[Show abstract] [Hide abstract]
ABSTRACT: The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (<25 °C). Antagonism of TRPM8 is currently under investigation as a new approach for the treatment of pain. As a result of our screening efforts, we identified tetrahydrothienopyridine 4 as an inhibitor of icilin-induced calcium influx in CHO cells expressing recombinant rat TRPM8. Exploration of the structure-activity relationships of 4 led to the identification of a potent and orally bioavailable TRPM8 antagonist, tetrahydroisoquinoline 87. Compound 87 demonstrated target coverage in vivo after oral administration in a rat pharmacodynamic model measuring the prevention of icilin-induced wet-dog shakes (WDS).Journal of Medicinal Chemistry 02/2012; 55(4):1593-611. · 5.61 Impact Factor
Article: Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.[Show abstract] [Hide abstract]
ABSTRACT: We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and murine TRPM8 channels, including those on primary sensory neurons. In vivo, M8-B decreased deep body temperature (T(b)) in Trpm8(+/+) mice and rats, but not in Trpm8(-/-) mice, thus suggesting an on-target action. Intravenous administration of M8-B was more effective in decreasing T(b) in rats than intrathecal or intracerebroventricular administration, indicating a peripheral action. M8-B attenuated cold-induced c-Fos expression in the lateral parabrachial nucleus, thus indicating a site of action within the cutaneous cooling neural pathway to thermoeffectors, presumably on sensory neurons. A low intravenous dose of M8-B did not affect T(b) at either a constantly high or a constantly low ambient temperature (T(a)), but the same dose readily decreased T(b) if rats were kept at a high T(a) during the M8-B infusion and transferred to a low T(a) immediately thereafter. These data suggest that both a successful delivery of M8-B to the skin (high cutaneous perfusion) and the activation of cutaneous TRPM8 channels (by cold) are required for the hypothermic action of M8-B. At tail-skin temperatures <23°C, the magnitude of the M8-B-induced decrease in T(b) was inversely related to skin temperature, thus suggesting that M8-B blocks thermal (cold) activation of TRPM8. M8-B affected all thermoeffectors studied (thermopreferendum, tail-skin vasoconstriction, and brown fat thermogenesis), thus suggesting that TRPM8 is a universal cold receptor in the thermoregulation system.Journal of Neuroscience 02/2012; 32(6):2086-99. · 6.91 Impact Factor
Article: Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.[Show abstract] [Hide abstract]
ABSTRACT: N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide (1) is a potent and efficacious inhibitor of PI3Kα and mTOR in vitro and in vivo. However, in hepatocyte and in vivo metabolism studies, 1 was found to undergo deacetylation on the 2-amino substituent of the benzothiazole. As an approach to reduce or eliminate this metabolic deacetylation, a variety of 6,5-heterocyclic analogues were examined as an alternative to the benzothiazole ring. Imidazopyridazine 10 was found to have similar in vitro potency and in vivo efficacy relative to 1, while only minimal amounts of the corresponding deacetylated metabolite of 10 were observed in hepatocytes.Journal of Medicinal Chemistry 06/2011; 54(14):5174-84. · 5.61 Impact Factor
Article: Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.[Show abstract] [Hide abstract]
ABSTRACT: The phosphoinositide 3-kinase (PI3K) family catalyzes the ATP-dependent phosphorylation of the 3'-hydroxyl group of phosphatidylinositols and plays an important role in cell growth and survival. There is abundant evidence demonstrating that PI3K signaling is dysregulated in many human cancers, suggesting that therapeutics targeting the PI3K pathway may have utility for the treatment of cancer. Our efforts to identify potent, efficacious, and orally available PI3K/mammalian target of rapamycin (mTOR) dual inhibitors resulted in the discovery of a series of substituted quinolines and quinoxalines derivatives. In this report, we describe the structure-activity relationships, selectivity, and pharmacokinetic data of this series and illustrate the in vivo pharmacodynamic and efficacy data for a representative compound.Journal of Medicinal Chemistry 06/2011; 54(13):4735-51. · 5.61 Impact Factor
Article: ChemInform Abstract: Synthesis of Benzo[b]carbazoloquinones by Coupling of Organostannanes with BromoquinonesChemInform 01/2010; 29(11).
Article: 183 TRPM8 SELECTIVE ANTAGONISTS ARE NOT EFFECTIVE IN NEUROPATHIC OR INFLAMMATORY PAIN IN RATSEuropean Journal of Pain Supplements 01/2010; 4(1):54-54.
Article: ChemInform Abstract: Palladium-Catalyzed Coupling of Naphthoquinone Triflates with Stannanes. Unprecedented Nucleophilic Aromatic Substitution on a Hydroxynaphthoquinone Triflate[Show abstract] [Hide abstract]
ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.ChemInform 01/2010; 28(47).
Article: ChemInform Abstract: Synthesis of Antibiotics WS 5995 A and C and Related Compounds by Palladium-Catalyzed Coupling of 2-Bromonaphthoquinones with Organostannanes[Show abstract] [Hide abstract]
ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.ChemInform 01/2010; 26(19).
Article: Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats.[Show abstract] [Hide abstract]
ABSTRACT: Antagonists of the vanilloid receptor TRPV1 (transient receptor potential vanilloid type 1) have been reported to produce antihyperalgesic effects in animal models of pain. These antagonists, however, also caused concomitant hyperthermia in rodents, dogs, monkeys, and humans. Antagonist-induced hyperthermia was not observed in TRPV1 knockout mice, suggesting that the hyperthermic effect is exclusively mediated through TRPV1. Since antagonist-induced hyperthermia is considered a hurdle for developing TRPV1 antagonists as therapeutics, we investigated the possibility of eliminating hyperthermia while maintaining antihyperalgesia. Here, we report four potent and selective TRPV1 modulators with unique in vitro pharmacology profiles (profiles A through D) and their respective effects on body temperature. We found that profile C modulator, (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)acrylamide (AMG8562), blocks capsaicin activation of TRPV1, does not affect heat activation of TRPV1, potentiates pH 5 activation of TRPV1 in vitro, and does not cause hyperthermia in vivo in rats. We further profiled AMG8562 in an on-target (agonist) challenge model, rodent pain models, and tested for its side effects. We show that AMG8562 significantly blocks capsaicin-induced flinching behavior, produces statistically significant efficacy in complete Freund's adjuvant- and skin incision-induced thermal hyperalgesia, and acetic acid-induced writhing models, with no profound effects on locomotor activity. Based on the data shown here, we conclude that it is feasible to modulate TRPV1 in a manner that does not cause hyperthermia while maintaining efficacy in rodent pain models.Journal of Pharmacology and Experimental Therapeutics 08/2008; 326(1):218-29. · 3.89 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Clinical candidate AMG 517 (1) is a potent antagonist toward multiple modes of activation of TRPV1; however, it suffers from poor solubility. Analogs with various substituents at the R region of 3 were prepared to improve the solubility while maintaining the potent TRPV1 activity of 1. Compounds were identified that maintained potency, had good pharmacokinetic properties, and improved solubility relative to 1.Bioorganic & medicinal chemistry letters 08/2008; 18(18):5118-22. · 2.65 Impact Factor
Article: Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.[Show abstract] [Hide abstract]
ABSTRACT: Transient receptor potential vanilloid 1 (TRPV1) channel antagonists may have clinical utility for the treatment of chronic nociceptive and neuropathic pain. We recently advanced a TRPV1 antagonist, 3 (AMG 517), into clinical trials as a new therapy for the treatment of pain. However, in addition to the desired analgesic effects, this TRPV1 antagonist significantly increased body core temperature following oral administration in rodents. Here, we report one of our approaches to eliminate or minimize the on-target hyperthermic effect observed with this and other TRPV1 antagonists. Through modifications of our clinical candidate, 3 a series of potent and peripherally restricted TRPV1 antagonists have been prepared. These analogues demonstrated on-target coverage in vivo but caused increases in body core temperature, suggesting that peripheral restriction was not sufficient to separate antagonism mediated antihyperalgesia from hyperthermia. Furthermore, these studies demonstrate that the site of action for TRPV1 blockade elicited hyperthermia is outside the blood-brain barrier.Journal of Medicinal Chemistry 06/2008; 51(9):2744-57. · 5.61 Impact Factor
Article: High-content screening analysis of the p38 pathway: profiling of structurally related p38alpha kinase inhibitors using cell-based assays.[Show abstract] [Hide abstract]
ABSTRACT: The complexity of the p38 mitogen-activated protein kinase (MAPK) signaling pathway presents challenges to understanding the efficacy of p38 inhibitors. Biochemical recombinant kinase assays and tumor necrosis factor alpha (TNFalpha) secretion assays are typically used to evaluate p38alpha inhibitors, but they do not provide insight into proximal intracellular events. Stimulation of the pathway evokes a cascade of phosphorylation events, accompanied by movement of molecules to different cellular compartments. Herein, we describe the profiling and potency comparison of a large set of p38alpha inhibitors with a pyrimidinone, imidazopyrimidine, or triazolopyrimidine core against biochemical recombinant p38alpha kinase activity, lipopolysaccharide (LPS)-mediated TNFalpha secretion by THP-1 cells, and a set of cellular imaging assays in SW1353 chondrocytes and baby hamster kidney cells. These pathway assays included p38 phosphorylation, MAPK-activated protein kinase 2 translocation, and heat shock protein (HSP) 27 phosphorylation. We established that HSP27 phosphorylation correlates well with LPS-induced TNFalpha secretion, validating our cellular imaging assays. We also found that the choice of cells and inducer can profoundly affect cellular potency results. High-content analysis may reveal signaling details, enriching our understanding of the mechanism of action of p38alpha inhibitors.Assay and Drug Development Technologies 09/2006; 4(4):397-409. · 1.90 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The mitogen-activated protein kinase (MAPK) p38 is a Ser/Thr kinase, originally isolated from lipopolysaccharide-stimulated monocytes. There are four isoforms of the enzyme (p38alpha, p38beta, p38gamma and p38delta), which differ in tissue distribution, regulation of kinase activation and subsequent phosphorylation of downstream substrates. These enzymes also differ in sensitivity to p38 MAPK inhibitors. The most thoroughly studied isoform is p38alpha, for which activation has been observed in many hematopoietic and non-hematopoietic cell types upon appropriate stimuli. p38alpha kinase is involved in the biosynthesis of the cytokines tumor necrosis factor-alpha and interleukin-1beta at the translational and transcriptional level. MAPK p38alpha represents a point of convergence for multiple signaling processes that are activated during inflammation, making it a key potential target for the modulation of cytokine production. The discovery and publication of p38alpha and a pyridinyl-imidazole-based p38alpha inhibitor initiated a huge effort by many companies to develop p38alpha inhibitors as potential treatments for inflammatory diseases. Herein, a brief overview is provided of the discovery and development of AMG-548 (Amgen Inc), a selective and efficacious p38alpha inhibitor, and its pharmacodynamic effects in a first-in-human study. Data from a phase I multidose clinical trial are also included. In addition, other p38alpha inhibitors that have advanced to clinical trials over the last three years are discussed, such as BIRB-796 (Boehringer Ingelheim Pharmaceuticals Inc), SCIO-469 and SCIO-323 (Scios Inc), and VX-702 (Vertex Pharmaceuticals Inc/Kissei Pharmaceutical Co).Current opinion in drug discovery & development 08/2005; 8(4):421-30. · 5.12 Impact Factor
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ABSTRACT: Since the discovery of p38 mitogen-activated protein kinase (MAPK) as a potential intracellular modulator that regulates the crucial biosynthesis and functions of pro-inflammatory cytokines (e.g., TNF-α and IL-1β), numerous groups have disclosed their efforts to find small-molecule p38 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases such as rheumatoid arthritis (RA), Crohn's disease (CD) and psoriasis. Although greater selectivity has been achieved with these newly disclosed series, their safety profile after chronic treatment remains a question to be answered in human clinical trials. The p38 inhibitors that have been disclosed in the recent patent literature (2000 – 2004) are summarised here. These compounds will be classified into series based on their intrinsic structures and by their binding modes, as revealed by either crystallography or molecular modelling.07/2005; 15(7):801-816.
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ABSTRACT: Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-alpha production in mice and exhibited good efficacy in the rat collagen induced arthritis model.Bioorganic & Medicinal Chemistry Letters 06/2005; 15(9):2409-13. · 2.34 Impact Factor
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Archive - Feb 3, 2014
FIT MINUTE - Ping Pong inspires perspirationSubmitted by Makenzi Henderson on Mon, 02/03/2014 - 11:50pm.READ MORE:
Ping Pong is a game you might play when you're bored or at a party. And, you might not realize you're getting some exercise while you do it. Find out why it's a great way to get off the couch and burn some calories in the Fit Minute! Full story...»
WWAY's Monday night sports - February 3Submitted by John Rendleman on Mon, 02/03/2014 - 11:46pm.READ MORE:
Unfortunately it's now 12 losses in a row for the UNCW men's basketball team. The Seahawks lost on the road on Monday against Drexel. Check out our game highlights. We also showcased high school hoops on Monday. This includes New Hanover-Hoggard and Cape Fear Academy-Harrells. Plus more! Full story...»
ONLY ON 3: WPD, NHCSO named in illegal strip search suitSubmitted by Holden Kurwicki on Mon, 02/03/2014 - 11:32pm.READ MORE:
Full story...»
R.A.D. comes to New Hanover CountySubmitted by WWAY on Mon, 02/03/2014 - 10:42pm.READ MORE:
Women can help themselves feel more secure with the help of the New Hanover County Sheriff's Office. Deputies said, for the first time, the agency is teaming up with the Rape Aggression Defense System, better known as RAD, to offer self defense classes to women at the Cape Fear Community College north campus. Full story...»
Grand jury indicts Southport cop in shooting death of teenSubmitted by WWAY on Mon, 02/03/2014 - 9:06pm.READ MORE:
A Brunswick County Grand Jury has indicted Southport police officer Bryon Vassey on voluntary manslaughter charges in the death of Keith Vidal, according to the District Attorney's Office. Full story...»
Progress made in backlog of food stamp applicationsSubmitted by Daniel Seamans on Mon, 02/03/2014 - 7:41pm.READ MORE:
Full story...»
Duke Energy reports coal-ash spillSubmitted by Daniel Seamans on Mon, 02/03/2014 - 7:30pm.READ MORE:
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School districts begin tough task of dealing with missed daysSubmitted by Brandon Taylor on Mon, 02/03/2014 - 7:25pm.READ MORE:
Students around the area missed nearly a week of school thanks to the threat and eventual arrival of snow and ice last week, but state laws about the school calendar make rescheduling that missed time a challenge for administrators. Full story...»
CFPUA working at multiple locationsSubmitted by Ashley Cimino on Mon, 02/03/2014 - 7:20pm.READ MORE:
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KITCHEN SCOOP: White Bean & Chicken ChiliSubmitted by WWAY on Mon, 02/03/2014 - 5:59pm.READ MORE:
Sure the weather is a bit warmer, but is it ever NOT a good time for chili? Alicia Ross has a variation of the classic for us in this week's Kitchen Scoop. Full story...»
NC man charged in DSS case appointed attorneySubmitted by WWAY on Mon, 02/03/2014 - 5:20pm.READ MORE:
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US Senate candidate Brannon defendant in tech suitSubmitted by WWAY on Mon, 02/03/2014 - 5:16pm.READ MORE:
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Berger pleads guilty to DWI, drug chargeSubmitted by Sarah Murphy on Mon, 02/03/2014 - 4:48pm.READ MORE:
Brian Berger will not spend any time in jail for his DWI charges. The New Hanover County Commissioner was back in court this morning closing the case on two arrests in the last 14 months. Full story...»
NC group urges teachers to reject contract offersSubmitted by WWAY on Mon, 02/03/2014 - 3:59pm.READ MORE:
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Wilmington beefs up security for Council meetingsSubmitted by StarNewsOnline.com on Mon, 02/03/2014 - 3:38pm.READ MORE:
Starting soon, anyone who wants to go to a Wilmington City Council meeting will have to pass through a metal detector. Mayor Bill Saffo said council members have inquired about added security at city hall for some time. Full story...»


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Tag: PtCruiser
iPad run over by a PT Cruiser, lives to tell the tale
We see a lot of examples of how Apple products can withstand abuse, but one of the more dramatic examples showed up in the TUAW inbox this afternoon. Reader Aaron sent us a link to a YouTube video (on the next page) demonstrating how an iPad belonging to a fellow employee handled being run over by ...
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Software Updatesmore updates
- Vizzywig 8xHD price tag now a very affordable $49.99
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- iOS 8.0.1 update now available (Updated -- Don't update!)
- NFL Mobile updated for 2014 Season with new Fantasy Football features, NFL Now integration


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Trade and Development Events
Challenges of Post-Conflict Economic Recovery and Reconstruction in the Sudan
September 24, 2004 // 3:30pm — 4:30pm
Africa Program
A discussion with Lual Deng, advisor to the Economic Commission of the Sudanese People's Liberation Movement, on "Challenges of Post-Conflict Economic Recovery and Reconstruction in the Sudan." His presentation will highlight the opportunities for economic growth in Southern Sudan, as well as prospects for international investment, "wealth sharing" arrangements and the economic impact of the ongoing peace negotiations. The full text of Deng's paper is available for download.
Book Launch -- A Continent for the Taking: The Tragedy and Hope of Africa
August 05, 2004 // 9:30am — 11:00am
Africa Program
A Roundtable discussion with Howard French, distinguished New York Times journalist and author of the recently published book A Continent for the Taking: The Tragedy and Hope of Africa. Historian Louis Gates, Jr. has described French's book as "A brilliant and nuanced meditation on the complexities of contemporary Africa. Essential reading for those of us who love Africa and for all those who wish to gain a fuller understanding of a continent that is sprawling, mysterious, and endlessly fascinating."
Dispersed Relations: Americans, Canadians, and North America's Perforated Border
May 21, 2004 // 10:00am — 11:30am
Canada Institute
Reginald Stuart discussed his project that proposes a new framework for examining how Canada and the United States and their peoples interrelate, in four broad realms: cultural, social, economic, and political/diplomatic.
Smart Borders, Virtual Borders, or No Borders: Homeland Security Choices for the United States and Canada
May 20, 2004 // 3:00pm — 4:30pm
Canada Institute
Rey Koslowski discussed options for North American border security particularly pertaining to the implications of introducing technologies into border security with an emphasis on the impending requirements of US-VISIT entry and exit procedures.
Book Launch--EU Trade Strategies: Between Regionalism and Globalism
May 06, 2004 // 6:30pm — 8:00pm
Global Europe Program
with editors: Vinod K. Aggarwal-—University of California at Berkeley and Edward A. Fogarty-—University of California at Berkeley. Other speakers include: Anders Ahnlid-—Minister of Trade and Economic Affairs, Embassy of Sweden;Peter Berz-—First Secretary for Trade Affairs, Delegation of the European Commission; and Heinrich Kreft-—Economic Counselor, Embassy of Germany.
Prime Minister of Canada, the Right Honorable Paul Martin, Speaks at Wilson Center Event
April 29, 2004 // 12:00pm — 1:00pm
Canada Institute
On the occasion of his first visit to Washington, Canadian Prime Minister Paul Martin delivered a speech focusing on bilateral issues and the issue of North American security, where he outlined the steps his government has taken to ensure that the Canada-U.S. border is more secure and open to trade.
An Opposition Perspective on Nigeria's Political Evolution
April 07, 2004 // 10:00am — 11:30am
Africa Program
Major General Muhammadu Buhari, a former Nigerian Head of State and President Obasanjo's principal opponent in Nigeria's 2003 presidential election, is currently leading the legal challenge to the conduct and outcome of that election. A ruling in his case, now drawing to a close before the Court of Appeal in Abuja, is expected by the end of March, and will thereafter be appealed to the Supreme Court by whichever side loses.
Assessing the Millennium Challenge Corporation
March 02, 2004 // 2:00pm — 4:00pm
Environmental Change and Security Program
In 2002, President Bush proposed a new initiative on foreign aid - the Millennium Challenge Account. Experts outline the initiative's principles and the challenges facing the newly-formed corporation.
Post-Cancun Assessment by Canada: Trade Policy Challenges for North America -- a roundtable discussion --
October 28, 2003 // 3:30pm — 4:30pm
Canada Institute
Canada's Deputy Minister for International Trade Len Edwards discussed trade policy challenges including the state of WTO negotiations in the post-Cancun environment, ongoing efforts to negotiate a Free Trade Area of the Americas, and the rise of regional trade initiatives.
Kenya – From Moi To Kibaki
September 11, 2003 // 10:00am — 11:00am
Africa Program
An address by U.S. Ambassador Johnnie Carson, who has just returned to the United States following four years as Ambassador to Kenya. One of the Foreign Service's most distinguished Africanists, Ambassador Carson has played a major role in assisting Kenya through a remarkably successful political transition. His address will focus on this transition – its meaning for Kenya and for Africa, and for American policy. Prior to his most recent Kenyan assignment, Ambassador Carson served as the Principal Deputy Assistant Secretary for Africa. He has also served as Ambassador to Zimbabwe, Ambassador to Uganda, and Deputy Chief of Mission in Botswana. In the aftermath of the Cold War, Ambassador Carson re-established an American diplomatic mission in Mozambique. In the 1980's, on leave from the Foreign Service, he served for over four years as Chief of Staff to the U.S. House Foreign Affairs Subcommittee on Africa.


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I really do appreciate the fast service from the time of ordering to the delivery date of the products that I order. I also...Read More ->
Impressive customer support. Always answer emails very fast and offer alternatives. I bought for the first time and I will buy again for sure. Thank...Read More ->


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GeekPlanetOnline is the proud home to some of the finest podcasts in the world. From the razor-sharp banter and film dissection of The Black Dog, to the bong-fuelled satrie of Mike & Ike's All-Star Summer Jamboree and the macabre yarns of Jim Moon's Hypnobobs, we like to think we have a show for everybody!
MICROGORIA 07 - 30 Years in the Box of DelightsWritten by Hypnobobs
Hypnobobs brings you a family of three podcasts! Originally what was one show (Hypnobobs)...
The Pubcast - The Heather Graham ScaleWritten by Irish Pubcast
Blackdog Interstellar SpecialWritten by Black Dog Podcast
So take a listen... And remember there's no receipt so you can't ask for this...


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Shirley MacLaine Named 40th Recipient of AFI Life Achievement Award
The six-time Oscar nominee won the Academy Award for best actress in 1984 for her role in "Terms of Endearment."
Shirley MacLaine has been selected by the American Film Institute to receive its highest honor, the AFI Life Achievement Award, which will be presented to her at a gala tribute on June 7 in Los Angeles.
She will be the 40th recipient of the award.
"Shirley MacLaine is a powerhouse of personality that has illuminated screens large and small across six decades," Howard Stringer, chair of the AFI's board of trustees, said in announcing her selection. "From ingénue to screen legend, Shirley has entertained a global audience through song, dance, laughter and tears, and her career as writer, director and producer is even further evidence of her passion for the art form and her seemingly boundless talents."
An Oscar winner in 1984 as best actress for her performance in Terms of Endearment, MacLaine made her film debut in Alfred Hitchcock's The Trouble With Harry in 1955. During the course of her career, she has earned six Academy Award nominations, six Emmy noms and seven Golden Globe Awards. She most recently appeared in the ensemble comedy Valentine's Day as well as the Lifetime movie Coco Chanel, for which she was nominated for both Globe and SAG Awards.
A prolific author, she most recently published the book I'm Over All That – And Other Confessions in April. Her latest film, Bernie, in which she stars with Matthew McConaughey and Jack Black, had its world premiere at the Los Angeles Film Festival in June.
STORY: April Memoirs: I'm Over All That
MacLaine's brother Warren Beatty received the AFI Life Achievement Award in 2008. They become the second family in the history of the award to boast multiple honorees, following Kirk Douglas and his son Michael, who were honored in 1991 and 2009 respectively.
The awards ceremony will be broadcast by TV Land on a date in June to be announced.
What Hollywood Earns
Top Galleries
What's Hot In Awards
'Interstellar': Inside THR's Roundtable With Christopher Nolan and Matthew McConaughey
Film Independent Spirit Award Nominations Announced
Inside THR's Actress Roundtable With Reese Witherspoon, Julianne Moore
Independent Spirit Awards: Good News for 'Birdman,' 'Boyhood' and 'Selma'
AMAs: Taylor Swift Plays With Fire in "Blank Space" World Premiere Performance


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Whether Louisville or Akron won the 2010 NCAA Soccer College Cup yesterday in California, it would be a first for either school. While Akron had been to the final four and the championship game in the past and come up short, Louisville had never been this far before.
Unfortunately for the Cardinals, the Akron Zips got to take home the NCAA Championship trophy (their first ever in any sport at the school) yesterday in Santa Barbara after a 1-0 victory against Louisville.
After a historic season and a first-ever #1 ranking, the Louisville Men's soccer team will be bringing home the Runner-Up trophy.
With 11 minutes left to play in the game, Akron scored after a second chance shot on a corner kick couldn't be cleared from the box. It was a heart-breaking goal for Louisville and one that GK Andre Boudreaux had no chance of saving. After several shots on goal throughout the match, a flurry of "almost-goals" in the last minutes of the game (and a possible hand ball in the box against Akron), Louisville couldn't find the equalizer to send the game into OT.
While the end result was just short of the team's ultimate goal, the Cardinals had a dream season, and one they can build on for years to come. Congratulations, Louisville Men's Soccer Team- you've made your city (and soccer fans alike) very proud!
|Churchill Downs' Twin Spires will wear red for Cardinal Red Day
|UofL is Final Four Bound
|Kentucky Athletic Hall of Fame Celebrates 50 Years
|Fort Larned wins Stephen Foster in impressive fashion
|Downs After Dark returns to Churchill Downs for action-packed Saturday night
|Successful Dan headlines Stephen Foster field
|Louisville Soccer breaks ground on new stadium


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Bazar de la Roma
Museo del Objeto del Objeto
Packing a collection of nearly 100,000 pieces, some as old as the Mexican War of Independence (1810), this two-story design museum...
Centro de Cultura Casa Lamm
This cultural complex contains a gallery for contemporary Mexican painting and photography as well as an excellent art library.
Multiforo Alicia
Behind the graffiti-scrawled facade is Mexico City's premier indie-rock club. A suitably dark, seatless space, the Alicia stages mostly...
Panadería Rosetta
Sublime sweet bread and baguettes are made fresh daily at this small bakery owned by chef Elena Reygadas, sister of award-winning...
Jardín Dr Chávez · interesting places nearby
Bazar de la Roma information
East of Avenida Cuauhtémoc, this market has used and antique items, large and small: books, beer trays, posters and furniture. A similar antiques and art market runs along Álvaro Obregón on the same days.


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Follow Sandy With Our Live Radar and Satellite
Follow Hurricane Sandy with our live radar and satellite as this storm makes its way into New Jersey.
Follow Hurricane Sandy with our live radar and satellite as this storm makes its way into New Jersey.
A mandatory evacuation order is now in effect for all Atlantic County barrier islands as of 8AM Sunday morning.
According to the Brigantine Office of Emergency Management Office via Facebook, Brigantine has issued VOLUNTARY evacuation orders or Brigantine Beach, NJ starting now.
A Mandatory evacuation order will be issued on Sunday October 28, starting at 08:00 A
Cape May County announced moments ago that there is a voluntary evacuation for all barrier islands in Cape May.
That voluntary evacuation will become mandatory on Sunday, before the full impact of hurricane Sandy hits the East Coast
Moments ago, officials in Clayton, Gloucester County announced that two teenage brothers have been arrested and charged with killing 12-year-old Autumn Pasquale.
An impaired driver crackdown will be conducted by the Egg Harbor Township Police Department this weekend.
A pair of popular grocery stores in our area will be closing up shop by the end of the year.
Earlier this year, Mainland Regional High School won Under Armour's "Finding Undeniable" contest and now they are the benchmark for other schools in the country that are trying to win this year. One of those other schools is Oakcrest High School in Mays Landing.
If you're a hockey fan like me, at this point, you'll take hockey any way you can get it. Luckily, ice hockey will be in Atlantic City next month!
A number of local students are recovering after a pair of South Jersey school buses collided this afternoon.
Coast Guard crews have helped rescue three people from a fishing vessel that was sinking off Cape May coast.
New Jersey and the nation go to the polls on Tuesday, November 6. Here's a preview of the election and how you make sure you get to cast a ballot and have your vote count.


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is there a place to go where a little girl might never have to know?
and is there a time of night when she'll ever feel it's safe to dim the light?
i know some things i'd rather not,
like, the time ahead is all the time you've got.
and one other thing i know:
out from under layer after dark layer,
as the years go by, a little girl can grow.
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Sub-Lease Space
available to Sub-lease
in Natick, MA
posted on May 16, 2013
Sastry Dwivedula
+1 (508) 318-4674
Peter Abair
Director of Economic Development
Property Description
We have a lab/office space of approximately 2000 SQ FT that is available immediately. It has independent entry and is a flexible space. It is at the Lobby level and is very convenient.
Past Use Description
It has been used as a Lab space recently.
Biotech Infrastructure Amenities
The lab has exhaust system ready for chemical fume hoods.
Xtal can share some of its equipment with the sub-lease company and can be separately negotiated.
Listing Details
|Property Use
|Lab, Office, Manufacturing
|This property has parking available
|Building Size (in Square Feet)
|Square feet available
Images (Click on images to view larger size)
About MassBio
MassBio is a not-for-profit organization committed to advancing the development of critical new science, technology and medicines that benefit people worldwide.
Founded in 1985, MassBio represents over 600 biotechnology companies, academic institutions, research hospitals, and service organizations involved in life sciences and health care, and works to advance policy and promote education, while providing member programs and events, industry information, and services.
Latest Updates
- November 14, 2014 SEF Presents: Vertex Case Study - Using Fixed Gas Detection for Hazardous Environments
- November 13, 2014 MassBio Brings IPP Vision Van & Shoemobile to MassBio Members
- November 12, 2014 MLSC Life Sciences Milestone Achievement Program (MAP) Funding Info Session & Incubator Showcase
- November 7, 2014 New Massachusetts Life Sciences Center grant program to fund milestone achievement by early-stage companies
- November 3, 2014 Candidates for Governor discuss biotech issues, policies


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Pitchers and catchers have reported for spring training; now it's your turn. The Tosa Baseball League is registering players for baseball and fastpitch softball. Children who live in Wauwatosa or attend Wauwatosa schools, and who are between the ages of seven and 15 as of September first, are eligible to play.
Tosa Baseball, which was founded more than 40 years ago, is an independent league. The league encourages a competitive level that is age appropriate for each bracket, and players get the opportunity to learn and play multiple positions to determine their best place to excel.
"Children develop athletic abilities at varying ages, so we ensure that all players see even playing time," emphasized James Ingbretson, league president.
Tosa Baseball is a co-ed league and is divided into four divisions: Rookie, for ages seven and eight; World, for ages nine and ten; American, for ages 11 and 12; and National, for ages 13 & 14.
Tosa Girls' Fastpitch is similarly divided into Junior, Minors, Majors, and Seniors.
Teams are drafted in late March or early April, and outdoor practices start in May on local fields in Wauwatosa and Milwaukee; however, registered players can take advantage of free indoor practices at Tosa Baseball's Extra Innings warehouse, located at the corner of 92nd Street and Center Street.
Games begin in June and are played through mid-July, at which time the league holds a tournament. At the end of the season, every player receives a recognition trophy.
Registration is available online http://www.leaguelineup.com/miscinfo.asp?menuid=32&url=tosabaseball&sid=455425696. The cost is $165 per player, but rebates are available for families who volunteer.
"The success of this league is dependent on volunteers and sponsors," said Ingbretson. "Many of our coaches played Tosa Baseball as children. The coaches, our team managers, equipment managers, special events coordinators and other key volunteers make this a fun, safe league for our families."
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- Acclaimed actor Michael York to keynote amyloidosis event
- Shop Small on Small Business Saturday
- Milwaukee/NARI Home Improvement Council Honors Barry Mandel With the "Building Milwaukee" Award
- Local Businesses Collect, Deliver More than 4,000 Pounds of Food to New Berlin Food Pantry


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Nampak FY HEPS From Continuing Ops Up 14%
Andre de Ruyter, CEO: Nampak speaks to Giulietta Talevi about latest results from the packaging...
Tsogo Sun Slides +7% On H1 Results
Marcel von Aulock, CEO: Tsogo Sun, discusses half-year results and the outlook for the gaming...
Ford Not Hitting The Breaks On SA
Jeffrey Nemeth, President & CEO: Ford Motor Company SA and President of the American Chamber of...
Ketso out in the cold?
Workers who hold a 6% stake in the company are likely to be unhappy about the potential loss of Gordhan
JSE rockets as resources drive market after China lowers rates
JSE delivers best daily performance so far this year on Friday as China lowers interest rates and stimulus talk in Europe buoys global markets
Google looks to get back into China
Google is considering bringing version of Play mobile-app store to China, a tentative but important step back into a country that Google mostly exited in 2010
Inspired by old hat from the emperor
The South Korean chicken mogul who bought one of Napoleon's famous two-pointed hats sees the French emperor as a guiding spirit for modern entrepreneurs
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Daily, we interview CEOs and executives whose companies have made the latest headlines.
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Stephen Gunnion and his panel of experts: Lesiba Mothata, Head of Market & Economic Commentary from Investment Solutions, Tertia Jacobs, Treasury Economist from Investec ICIB and Stanlib Chief Economist, Kevin Lings make sense of today's decision on rates.
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For technical share analysis and a call on whether it's a Buy/Sell, Giulietta Talevi and Independent Technical Analyst Frans de Klerk bring you an informative half-hour discussion on technical share analysis. Call in LIVE on 011 280 3899.
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Peter Bruce and the Editing Allowed team take a critical and sometimes irreverent look at the week's biggest news.
Business Q&A with Emilian Popa, Groupon South Africa CEO
With the Retail Congress Africa conference underway, we look at how e-commerce potential across Africa can be maximised - that's with Emilian Popa, Groupon South Africa CEO.
The Business of the Arts
Business and Arts South Africa held its Art in Business Symposium at the Gordon Institute of Business Science. Focusing on the theme "How the arts can innovate your business", we find out how marketing and brand management intersects with the arts.
Traders Corner
If you're still not sure what the chartists are going on about when they talk 'reversals' and 'candles', then make sure you tune into Traders Corner tonight at 8.30pm. Founder Garth Mackenzie will run through the most useful of technical symbols to help you make your trading decisions.
Share My Portfolio
Stephen Gunnion and his guests: Warwick Lucas from Galileo Capital and Claudius Rostoll of AG Capital answer some of your portfolio queries on Share My Portfolio. Please send us an e-mail: email@example.com.
The Money Show
Gerald Mwandiambira, Winnie Kunene and Sugendhree Reddy from Standard Bank discuss how to plan for the festive season from the beginning of a year especially if you don't get a bonus.
Ask the Property Experts
As the festive season approaches, many look to find relaxing getaway spots. Kura Chihota finds out what the Leisure Property space has in store for the investor and the end user with John Loos from FNB and Marc Wachsberger of The Capital.
The Big Small Business Show
Diederik van 't Hof, owner of Roof Rats, gives feedback on how their business of cleaning dust, animal droppings and even stray bats out of ceilings, has expanded in the past year.
Doing Business in the 21st Century
Leigh Roberts and Mervyn King look into integrated thinking: what it is, the benefits thereof and what tools to use to embed integrated thinking. Joining in on the discussion are Mohamed Adam: Corporate Counsel from Eskom and Graham Terry: Senior Executive of Strategy and Thought Leadership at SAICA.
TUNING INTO AFRICA - The Growth of the TV Sector
Africa is on the precipice of exponential growth in the TV sector, in particular Pay TV across Sub-Saharan Africa. These are exciting times for the viewer but they are especially exciting if you work in the industry or are looking for an investment opportunity.


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MVC Widget Error
7 Tips to Prepare for Your Appointment
The key to a successful appointment is communication. To get the most out of your visit, prepare ahead of time so you can lead the conversation with your doctor. These 7 tips will get you ready
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Check insurance plans, locations and make an appointment
Is Dr. Charlton accepting new patients?
- Yes.
What insurance does he accept?
- Aetna
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- Blue Cross Blue Shield of California
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- Golden Rule
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- MultiPlan
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Office Locations
- USC Orthopedic Surgery Assocs
- 1520 San Pablo St Ste 2000
- Los Angeles, CA 90033
- (323) 442-5300 (Office)


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Come to Safeco Field for this special "blackout" event! Read More »
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Maroon 5
Maroon 5 is coming to the Tacoma Dome! Read More »
Oktoberfest Monroe
Have some fun with the whole family at Oktoberfest Monroe! Read More »
Usher Concert
Usher's taking off on a world tour and one of the stops is in Seattle! Read More »
Brooke & Jubal's Happy Hour @ Cactus Moon Saloon
Don't miss out on the Fun Thursday nights with Brooke and Jubal's Happy hour at Snohomish County's biggest Sports Bar – Over 5,000 square feet of fun! 31 – 42" Plasma screens, darts, games, and interactive countertop games at The Cactus Moon Saloon In Everett!!! Read More »
2014 NFL Kickoff Concert Starring Pharell
The spirit of the NFL community in Seattle will be on display as fans nationwide prepare to get back to football with a FREE concert by Pharell Williams and Seattle's own Soundgarden. Read More »
Disney On Ice Let's Celebrate!
Watch the Disney magic come to life! Read More »
So You Think You Can Dance
Join the MOViN team as you see the live performances from So You Think You Can Dance! Read More »
Pick-N-Pull Labor Day Weekend Van Hit
Where shopping a big sale shows how much labor it can be. Read More »
Salmon Days Golf Tournament
Tee off at the Salmon Days Golf Tournament for a day full of fun! Read More »


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Find records of Lorraine Thomas
Find birth, death, marriage, military, and other records of Lorraine Thomas at Ancestry.com.Search for records
Biography & Family History Add details
Lorraine Thomas (1918 - 2001) was born on March 26, 1918. She was born into the Thomas family.
There are no known marriages or children on file for Lorraine. Lorraine died on November 12, 2001 at 83 years old.
Lorraine Thomas's last known residence is at Farmington, Saint Francois County, Missouri.
The data on this page comes from the official record for Lorraine Thomas in the SSDI (United States Social Security Master Death Index). According to information provided to the SSDI, this death record has been verified by a family member of the deceased. This data can be considered very accurate. What is the SSDI?
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Possible Relatives
- William Frank Thomas
- ·
- Ingalls Odonnell Thomas
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- Myra Thomas
- ·
- Richard Thomas
- ·
- Janie Duncan Thomas
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- Allen Hunter Thomas
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id lay odds if you reboot them they will ping again quite happily
I have a load of Procurve switches, mainly 2510-48/24's. They all appear to be working (no-one complaining). But the strange thing is, some will ping but most will not. Is there something obvious. Every switch is setup in exactly the same way. I've tried it from different machines and browsers but come up with the same, cannot ping.
Any suggestions?
id lay odds if you reboot them they will ping again quite happily
I was going to give that a go when school finishes - cheers
Can you access them via the console / web ui? Do they return snmp data ok?
If they were Netgears, I'd say they've died of overheating, but I haven't had that happen to a HP.
Wack the latest HP firmware's on them, i had a switch a few weeks back which didnt wanna play ball at all, upgraded the firmware and boom all started working, think it was a HP ProCurve 2610-48
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text:
- Address:
4 rue Lubin Brin
Gustavia, Saint Barthélemy 97133Neighborhood:
St. Bart's
- Cuisine:
FrenchPrice: $50 and over
- Dining Style: Casual Elegant
- Website: http://www.ilovebonito.com/
- Phone: 0590590279696
- Hours of Operation:
Opens at 6pm
Open everyday during high season
Closed on Wed during low season.
- Payment Options: AMEX,MasterCard,Visa
- Cuisine: Seafood, French
- Executive Chef: Chef Laurent Cantineaux
- Dress Code: Casual Dress
- Accepts Walk-Ins: Yes
- Additional Details: Banquet/Private Rooms, Bar/Lounge, Full Bar, Late Night, Private Room, Smoking Area, Smoking Area (bar only), View, Wine
A word from Bonito
Alexandra, Alicia, Jonas, Juan-Carlos and Laurent welcome you to Bonito! Bonito is a freshly renovated venue with unique French-Latin cuisine and a great view over Gustavia Harbour.Continued
Foodspotting photosSee all photos
Awards voted by OpenTable diners
- Diners' Choice WinnerMost Booked
Bonito - Best Restaurants in St. Bart's ›
Bonito reviews from OpenTable diners
3 reviews since July 31, 2014
- Food3.3Service3.3
- Ambiance4.7Noise LevelModerate
vibrant bar scene (3)scenic view (2)hot spot (2)romantic (1)fit for foodies (1)good for groups (1)great for outdoor dining (1)neighborhood gem (1)special occasion (1)Show More
- One of the topKajollDined on 8/8/2014everything its above the average of restaurants in St. Barth. Outstanding decoration Great views Great Food Really good service If you are visiting Saint Barth its a mustSpecial Features:
- The following 51 reviews are from the Bonito reviews archive.
- OutstandingAmazingDined on 7/14/2014This was our second time at this restaurant and we love it. The chef is amazing! The staff is friendly and treats you like you are royalty. The DJ plays a wonderful mix of music.Special Features:
- Beautiful BonitoLaMaDined on 4/27/2014This is consistently one of the best restaurants in St. Barths. Located above Gustavia harbor, it has a beautiful romantic view of the town, and the food is consistently excellent. We enjoyed both the shrimp ceviche and the crispy tuna ceviche appetizers, followed by sharing the angus beef for 2, which was a perfectly prepared and presented piece of meat, and was so large that we had to pass on dessert. Although pricey (as is all of St. Barths - it is part of the experience!), Bonito is good value. We have been there many times and it never disappoints.Special Features:I would recommend this to a friend.
- Ohh, the sea bass!LuvtheseabassDined on 4/24/2014Everything was just outstanding! Service, atmosphere, it is absolutely one of our top favorites on the island. Did I mention the sea bass? My husband had the mahi mahi which was also wonderful but I will dreaming about the sea bass until next time!!Special Features:I would recommend this to a friend.
- Great Harbor ViewJcpc21Dined on 3/29/2014We were here for Bucket Race week-end so everything is very crowded but Bonito seated us right on time, service was impeccable. We shared the 36 ounce rib eye, perfectly seasoned and grilled to our exact request. We will return, an excellent restaurant, well run.Special Features:
- One of the best ST Bart's places foMtd3206Dined on 3/26/2014Location,view,staff,chef and food met and exceeded our expections!Special Features:I would recommend this to a friend.
- Delightful SettingRstaryDined on 3/26/2014We enjoyed this open air venue with a gorgeous view of the harbor. The sailboats below accented the scene with their lighted masts. The sea bass was exquisite and the vibe from within was the perfect setting that made this an extra special meal!Special Features:I would recommend this to a friend.
- You cannot go wrong at BonitoRSMMathewsVIPDined on 3/13/2014This is one of our favorite places to dine anywhere in the world. The view is spectacular and the ambience is exquisite. The food is top rate with service to match. It just would not be a visit to St. Barth without an evening at this wonderful restaurant.Special Features:I would recommend this to a friend.
- Another splendid evening at BonitoOpenTable Diner Since 2011Dined on 3/12/2014we enjoyed our March 12th meal at bonito so much we booked again for the following week march 20th to celebrate a birthday with friends who have never been to St. Barts before. If you go to one restaurant while you are on the island, this should be it.Special Features:I would recommend this to a friend.
- no question no answerMikeDined on 3/8/2014We were not asked how the entre was after serving. rWhen the plates were taken they asked. Too late. Tuna was boring and very disappointing.I would recommend this to a friend.
- Bonito simply the best on St. BarthOpenTable Diner Since 2010Dined on 2/7/2014Delicious food and excellent wines! The view is wonderful and the service is top notch! A must while in St. BarthSpecial Features:
- Hillside gem with a beautiful viewBlackjackDined on 1/18/2014A delightful location and one of the best restaurants on St. Barth. Spectaulor views of Gustavia Harbor with outstanding food and wonderful, friendly service.Special Features:
- Everything was fabulous. TheJulieDined on 12/27/2013Everything was fabulous. The food, the setting, the service, the atmosphere! We loved it and went back a second time in the space of 5 days! Special mention for the chocolate tart ;-)Special Features:I would recommend this to a friend.
- Great Food!StBarthFanDined on 12/24/2013Food was fantastic as always, but it was very busy and the service suffered. Only complaint - ordered cocktails and they were so full of ice that there was barely any drink in it. 2 sips and gone.Special Features:I would recommend this to a friend.
- Lovely restaurant & excellent foodhoneymoonDined on 12/20/2013We were on our honeymoon in St Barts and ate here on a Friday night. The food was excellent and it was very romantic with a lovely view of Gustavia harbour. Waiters were polite and friendly without being intrusive. This was one of the best meals we had whilst eating out in St Barts and I would recommend it to anyone.Special Features:I would recommend this to a friend.
- Worth Every PennyMUPTVIPDined on 12/17/2013We visited while stopping in St Barths from a ship. The restaurant is relatively close to harbor and has a delightful view even at night. Appetizers and main courses were fresh and inventive. Wines by the glass were very nice. Easily the best meal we had in the Caribbean this trip. Deserts were delicious and not overpowering. Priceas are as expected in St. Barths but worth it.Special Features:I would recommend this to a friend.
- Great Food Bad Table SelectionSlatsVIPDined on 11/30/2013The food was excellent as usual but we were seated next to a family with two children playing video games and then a bunch of cruise ship passengers who wondered if the menu was in dollars. We just expect more when spending that type of money.Special Features:
- bonito . ambience to die fornec78Dined on 11/12/2013Fantastic restaurant . Lighting music and decor all combine perfectly to create the perfect ambience.great menu and equally good food. Had the best champagne cocktail I've ever had.probably overall one of the best restaurants I've ever been to including our hometown of London.Special Features:
- Exceptional evening at BonitoHoneymoonersDined on 11/11/2013We are Australian and were recently travelling on our honeymoon in St Barths. We are foodies and this restaurant was exceptional. I have described the sea bass as the best sea bass I have eaten. The evening was a highlight of our month holiday. From the lychee loves coco cocktail to the perfect scenic view this restaurant exceeded our expectations and our expectations were high. Booking was seamless and staff aimed to make our night special.Special Features:
- Sunset dining at bestDocjuanDined on 7/6/2013Perched on a hill overlooking Gustavia harbour, with a fair number of tables right on the balcony, this restaurant is the perfect spot for a sunset drink before dinner. The setting is magnificent, the decor elegant, the service attentive, the food iexcellent. Everything is in tune with this beautiful island. We will return.Special Features:I would recommend this to a friend.
- Hot spot with a matching priceFrankDined on 7/1/2013This place comes across really cool. The room has a great feel and the people were great. The longer you stay, the more you realize it is a night-spot with pretty good food - not great food, masquerading as a restaurant. The stealth dance-floor hidden by comfy couches, the DJ rig, the flirty drink titles and most of all the price. This place was good but way over priced considering the choices on the island, especially for seafood. Would I return? Only if the food and price were to match.Special Features:
- Bonito is the restaurant ofOpenTable Diner Since 2012Dined on 3/27/2013Bonito is the restaurant of refined perfection in every way found by us in the stunning paradise of St Barths. Our wife and my daughters (15 & 6) along with me had an unforgettable evening. The food , wine, ambiance, and the staff were par excellence! A special thanks to the sommelier for the great wine choice and also to Juan Carlos who made every effort to exceed our expectations including a Cuban cigar to satisfy my desire. The culture and outstanding aesthetics of Bonito are a joy and easily permeate every aspect of this lovely gem in Gustavia. We will be back next year:) Thanks for the memories!!! Au Revoir, ShankarSpecial Features:
- Best restaurant in St. BarthsCristinaDined on 3/23/2013Everything about Bonito is perfection from the food to the service to the view. A definite must! The sommelier is amazing!Special Features:
- Good food - Not such great service!jwachDined on 3/19/2013We found the food very good and the staff not particularly professional. We showed up on time, the restaurant was not full and it took much to much time to seat us. When we were finally seated, the wait staff appeared to be preoccupied with each other rather than concentrating their attention to the patrons. It took a long time to receive the food from the kitchen and once it arrived, our waiter disappeared and never came back to ask if everything was OK, which it was not. We will not return to Bonito nor will we suggest the restaurant to friends.Special Features:
- Bonita continues to set the pace.RSMMathewsVIPDined on 3/13/2013Absolutely hands down the best meal we had on our 10 days on St. Barth. Everything is spot on from the service to the view to the wonderful food, beautifully prepared and art directed to a T. As with everything on St. Barth, it doesn't come cheap but this meal was not our most expensive - leave that to Pacri and Santa Fe -- but by far the most perfect evening of all.Special Features:
- Sunset over Gustavia HarborOpenTable Diner Since 2006Dined on 3/6/2013Excellent location with great sunset outdoor dining views. Food was outstanding, both their specialty (ceviches) and well-executed impressive main entrees.Special Features:I would recommend this to a friend.
- Plus: Beautiful setting, popularOpenTable Diner Since 2008Dined on 3/2/2013Plus: Beautiful setting, popular venue, excellent food and service, easy to make reservation. Minus: small portions, no moderate priced wines by the bottle.Special Features:
- Service has deteriorated greatlyOpenTable Diner Since 2007Dined on 3/1/2013Service has deteriorated greatly in recent years. We been several times since opening,and have spent many large meals there with many friends, but they have been getting progressively lazy in their service, and attention to what good service means in a proper high-end, St. Barth's restaurant. Food is good, but not worth the prices they are asking--overpriced-even for St. Barth's. Only the Sommelier appeared to be putting in any effort, with good recommendations, and helpful information, while the wait staff and managers were not engaged in much of anything. It was a Friday night, and they were not understaffed, but definitely not interested in maintaining the reputation of a previously great restaurant.Special Features:
- beautiful dining with a greatAndersKDined on 2/28/2013beautiful dining with a great view, charming and very professional service, innovative and very tasty food - so all in all a great place for dinner!Special Features:
- Bonito is a fabulous restaurant.OpenTable Diner Since 2011Dined on 2/21/2013Bonito is a fabulous restaurant. I still love it even after the second time. Service, ambiance, food , scene and crowd are the best in St Barth's.Special Features:
- While our service was poor,KWHSVIPDined on 2/21/2013While our service was poor, it was largely due to the table next to ours which got all the attention. Seems when you sit next to a Russian tycoon that is likely to happen. At least we were in the right place...Special Features:
- Bonito disappointed us thisOpenTable Diner Since 2002VIPDined on 2/14/2013Bonito disappointed us this year. The view is wonderful if you can get one of the seats overlooking Gustavia. The decor is beautiful. The sommelier enthousiastically recommended the "drink of the day". I KNOW better - shame on me - it was 28 euros. Food was fine but far from amazing. We will probably skip Bonito next year.Special Features:
- The food was amazing! OneOpenTable Diner Since 2012Dined on 2/14/2013The food was amazing! One of the best restraunts I have eaten atSpecial Features:
- Very good food, very goodAnnieb42VIPDined on 1/28/2013Very good food, very good service, but outdoor dining was accompanied by very strong odor of sewage. It wasn't the restaurant's fault, but ruined our dinner, which was expensive
- We chose it for the location.OpenTable Diner Since 2008VIPDined on 1/24/2013We chose it for the location. It sits on a hillside in Gustavia with great views of the harbor. The interior is nicely decorated as well. We are very used to the high prices in St. Barth but were shocked at the wine list. We could not find a bottle of wine for less than $100. The food was also very high priced. I chose a ceviche and salad while my husband had the risotto. The spiny lobster salad had 4 very thin slices of lobster tail, far too little to be called a lobster salad. All of our dishes were loaded with salt. The next day we were comparing restaurant choices with another couple and they had the same experience. Too much salt. Chef needs to modify recipes and wine prices need to get more realistic.Special Features:
- We go there every year inStBarthFanDined on 12/23/2012We go there every year in St. Barth and it never fails to please! Fantastic as always!Special Features:
- Food was fabulous, serviceOpenTable Diner Since 2012Dined on 12/15/2012Food was fabulous, service was fabulous. Amazing meal all round. Perfect for a romantic dinner setting without being pretentious. 100 % must do in st Barths.Special Features:
- Made open table reservationOpenTable Diner Since 2011Dined on 12/8/2012Made open table reservation one month before arrival. Requested specific table. Request approved. Visited restaurant 5 days prior to reservation and confirmed reservation and table guaranteed. Upon arrival, informed that table promised to another and not available to us as twice promised. After vigorous complaint, given table. Sommelier offered wine suggestion. Uninformed that there was a charge for his services. "Wine suggestion" service charge of 50 euro added to bill. Never charged anywhere ever before for this service. Will not return to this restaurant.Special Features:
- Great restaurant! Great peopleOpenTable Diner Since 2012VIPDined on 12/4/2012Great restaurant! Great people watching. Definitely a st barths must!,Special Features:
- Decor was my favorite otheOpenTable Diner Since 2006VIPDined on 11/29/2012Decor was my favorite othe island...staff was great..food could be better if they just stop oversalting it. They salt it and then finish it off with the flaky sea salt. The desserts were disappointing except the fruit with sorbet.Special Features:


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Photos and Description of this 3 bedroom holiday apartment in Mauritius West Coast and Center
3 bedrooms, 2 bathrooms, sleeps 6
The apartment is situated in the heart of Flic en Flac, a very popular beach resort area located on the West coast of Mauritius.
Fully furnished, with a fully equipped kitchen including microwave, washing machine and cooking utensils. Partly air conditioned, in bedrooms or and the lounge area, all other rooms have fans.
The rates include housekeeping service 3 times a week excluding public holidays.
The complex of Flic en Flac has all the facilities required at nearby walking distances such as banks, supermarkets, pharmacy, discotheques, restaurants, casino, boutiques and much more. The beach is one of the most beautiful on the island, boasting a transparent blue lagoon with the most incredible and romantic sunset. Each complex has its own leisure facilities and 24hr security service. This modern complex has 45 apartments with a magnificent swimming pool in the centre.
Airport transfer or car rental: Please note that we can provide you with airport transfer or car rental as a discounted rate.
- Airport transfer rates- depending on the number of people. Please enquire for details.
- Car rental- Discounted rate per day. Unlimited mileage and comprehensive cover. Cars delivered at the apartment at no extra cost. 7 seater available
- Suitability:
- Long-term Renters Welcome
- Low Allergen Environment
- children welcome
- pets not allowed
- smoking allowed
- suitable for elderly or infirm
- wheelchair accessible
Guestbook comments from the owner
Dear Mr Ramhit,
I hope this email finds you well. With this email I only wanted to express our thanks on behalf of my familey for the wonderful stay we had in your apartment in Mauritius. My family had a great vacation and very much appreciated your support and assistance whenever they needed it.
Unfortunately we are not able to provide feedback on the Holiday-Rental web-site. We tried it various times in the past months, but the server does not accept our data. Please feel free to quote us and we were very happy with the service and appartment.
Kind regards
Kay-Uwe Neumann


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A ring vanishes from a spectator's hands, and reappears in a solid Brass box with a screw-on lid which may be taped down. An extra long thread is provided on the lid, which requires some time to open.
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Sing Sind Ring Box Report this review
Verified buyer Pro Privacy ON (login to see reviewer names) on May 2nd, 2013
This prop was delivered to me in England in Record time, great service.
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Verified buyer Pro Privacy ON (login to see reviewer names) on August 19th, 2014
The trick is well made, and the gimmick is easy to work. This is a pretty good value for the price in that there are many other ring-boxes that are much higher priced. It only gets a "3" rating because, though I have not performed the trick for an audience, in my opinion the gimmick could be easily spotted. I also believe that this ring-box would withstand only minor inspection by a spectator.
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Saffo-caster and catlin-ugh
Submitted by specialdeal (not verified) on Fri, 09/17/2010 - 8:49am.
Same result from same boys who have given us CFPUA, skyways, and the wasteful convention center= good for them and their cronies the developers and others-not so good for all the rest of us. We need a culture change in City and County---lets starte in County with