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hey , well i got invited to come to a big modelcar fair / show and show of my garage and rods ..
well the garage was ment as a simple dio to take pics of my models .. that got a bit out of hand
so i have to get the outside looking a bit decent because i never build this with care for the outside ...
the fair / show will be in september and wil actually be the first time i ever go to something modelling related .. i have plenty of time to finish the garage ..
so i thought i'd add more small detail , more will follow in the next weeks / months ..
everything you see on these pics is fixed / glued into position .. because i will have to transport it i thought i'd fix everything on its place ..
added some posters and more smalls .. need to create more atmosphere now with smalls and other stuff
1/24-25 hotrod garage diorama
Posted 01 June 2013 - 01:58 AM
hey , well i got invited to come to a big modelcar fair / show and show of my garage and rods ..
Posted 01 June 2013 - 05:19 AM
Loving this dio Richard. Will be watching for more details and the exterior modifications.
Posted 01 June 2013 - 05:48 AM
Richard, I've loved this dio since the beginning. I know exactly how these things get way out of hand and become much more than we ever intended!
The only thing I see is that steering wheel on the shelf on the back wall. I don't think one would stand up like that. It would more likely be hung on a hook, or laying down on a shelf.
Posted 01 June 2013 - 09:32 AM
thnx and yes i know about the steering wheel but i hung it and that looked weird
Posted 01 June 2013 - 12:42 PM
I love this stuff. First, thank you for taking the time to post this and share your weathering skills. I hope I can get one of these built someday.
I do see one thing missing, a car rim bolted to the wall for the air hose. One would look great on the end of your low wall, right out in the center of the shop for easy access. One for a water hose would be handy as well.
The photos with the light shining through the windows are awesome!
Posted 01 June 2013 - 10:05 PM
thnx tom ! and thats acutually a awsome idea , best would be to use a steelie rim and i have one thats perfect !! i had a spare steeelie rim (only one) so i can def use that ..
Posted 02 June 2013 - 01:12 PM
That's it, I should have mentioned the old steel wheel. Another common item is using the empty 15gal oil drums for trash cans.
Posted 09 June 2013 - 03:09 AM
That's it, I should have mentioned the old steel wheel. Another common item is using the empty 15gal oil drums for trash cans.
made it today , kept it fairly simple also added wheel stop blocks , and a lot of small parts everywhere
Posted 09 June 2013 - 03:11 AM
It just keeps getting better!
(I know I've said that before, but it's no less true)
David G.
Posted 09 June 2013 - 09:01 AM
Posted 10 June 2013 - 04:14 AM
added a worn v8 on a pallet with a big cloth hanging over the stransmission
a box with stuff for oil spills ..
seen from the other side also shows the detail of the mill a bit better
weathered the poster on the wall
Posted 10 June 2013 - 07:19 AM
I've enjoyed every page of this!! Thanks so much for sharing your talent and skill...!
Posted 10 June 2013 - 07:41 AM
We've been fooled. I just checked Richard's street on Google Street View and this building is right down the road from him!
(at least it looks that good!)
Posted 10 June 2013 - 08:18 AM
thnx and @ tom >> hahaha lol .. thnx
Posted 10 June 2013 - 09:24 AM
Thats about as real as it gets....Nice!
Posted 14 June 2013 - 10:49 PM
yesterday i took some scrap styrene and made a cabinet , just real simple to put somewhere when taking pictures ...put some chrome knobs on the doors , will ad a decal to the side maybe ...
Posted 15 June 2013 - 01:51 AM
Richard, you have some very serious modeling skills, KODOS to you Sir, you have done an absolute magnificent job on this dio!!
Posted 15 June 2013 - 03:34 AM
Wonderful!!!!! Thanks for the postings!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Posted 15 June 2013 - 03:45 AM
yesterday i took some scrap styrene and made a cabinet , just real simple to put somewhere when taking pictures ...put some chrome knobs on the doors , will ad a decal to the side maybe ...
That looks great Richard! Guys, as Richard said, this is a simple piece. Once you've got the eye, you can break an item like this down to shapes and make it out of Evergreen sheet or basswood very easily. You can even start out with a small plastic box shape you find in your parts box!
It is very fulfilling to be able to sit down and produce something like this start to finish in one sitting. A good way to get past modelers block!
Posted 15 June 2013 - 10:42 AM
I just looked at this entire topic...
Great work! So much to see and learn


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This page contains Cheats for Frogger 3D organized by sections for 3DS. Frogger 3D is a Action General game, made by Alpha Unit, released on Sep 20, 2011 and published by Konami. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
- Developer:
Frogger 3D 3DS CheatsAlpha Unit
- Publisher: Konami
- Genre: Action General
- Release Date: Sep 20, 2011
- ESRB: Everyone
Complete every stage making sure to not skip over any when the path branches off and beat the game. The question marks on the main menu will now say Challenge....From: hana123
Once you beat the game. World 7 will be accessible. World 7 is a faster and far harder form of World 1. Beating World 7 will unlock 8 and back to back up to World 12 all of which are harder versions of worlds 1 through 6....From: Ryan-is-ere
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an Frogger 3D expert then please try to help others with their questions.
How do I unlock the achievement in World 1 Stage 1?...
Posted on: 12-17-2013
Zombie Panic In Wonderland DX - First Look Trailer
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subset: commoncrawl


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2014 long range winter forecast - farmers' almanac, This is our forecast for the winter of 2013-14. for the 2014-15 winter outlook, click here » this forecast is for the united states. for the canadian forecast, click. 2014 canadian winter forecast - farmers' almanac, Every time i read this so called almanac it gives me the same weather reports for the long rage all the time , its not a surprise that us ontario`s get bad winter. Old farmer's almanac: weather forecasts gardening moon, Old farmer's almanac offers free long range weather forecasts, full moon dates, weather history, sun rise and set times, best planting dates, and folklore..
Farmer's almanac 2013 2014 us winter outlook snow forecast, Check out more snowboarding photos here check the canadian winter forecast for 2014 here and check out last season's prediction here and judge for yourself how the. Winter 2013 forecast - farmer's almanac 2013 winter, For almost 200 years, farmer's almanac has forecasted the winter weather with an extremely high success rate. after the 4th warmest winter on record, farmer's almanac. Farmer's almanac 2013-2014 canadian winter forecast snow, Check out more snowboarding photos here check the farmer's almanac 2013-2014 winter outlook for the united states here. read the original farmer almanac post here.
Farmers' almanac: super bowl 2014 weather may create, Lewiston, maine — the farmers' almanac is using words like "piercing cold," "bitterly cold" and "biting cold" to describe the upcoming winter. and if its. Long-range weather forecast 2014 united states and canada, Get your long-range weather forecasts for 2013 and 2014 for the united states and canada, compliments of the 2014 old farmer's almanac, the oldest almanac and. Farmers' almanac - wikipedia, the free encyclopedia, History . the farmers' almanac was founded in morristown, new jersey, in 1818 by editor david young and publisher jacob mann; this was, coincidentally, two years.


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Hellfest just released the announcement of the first bands confirmed for the tenth anniversary of the Festival. This Years Festival will be held the 19, 20 and 21Th of June. Festival's...
Hellfest 2015
Steve Rothery – Interview @ Bush Hall, Londo...
After more than 30 years of success with Marillion, Steve Rothery finally puts out his first solo album. Riff magazine sits down with the legendary guitarist to analyze "the Ghosts of Pripyat" and the ideas that surround it.
Flying Colors – Steve Morse – Intervie...
Riff sits down with legendary guitarist Steve Morse, for an in depth interview about Flying Colors' latest album 'Second Nature'
Obituary – Interview at Motocultor
Interview with Donald Tardy from Obituary on the occasion of their concert at Motocultor Festival, in Saint-Nolff. Interview: Morgan Bernard Camera: Stephane...
Thursday 14th, August, the town of Saint Nolff (Brittany) had to cope with a not so unusual crowd, as the seventh edition of the Motocultor Festival was about to start.
Brontide – Interview + 'Artery' ...
2014 marks the launch of Brontide's ambitious album "Artery". Riff magazine sits down with the band and examines the plan and process behind their long awaited sophomore effort.
Yann Le Baraillec – Motocultor Festival
God Macabre
Angra – Interview 2014-06-24 @ The Underworl...
Celebrating 20 years on their ground breaking album "Angels Cry", Riff Magazine got a chance to sit down with the legendary Brazilian band to discuss their still untitled 8th album as well as their illustrious past.
Electric Moon – Interview @ The Underworld, ...
Another great night of psychedelia, as Electric Moon again land their ship in London. Riff magazine got itself abducted, to bring you this candid interview with the band.
People at ViseuRockFest
Viseu RockFest People Point&Click
CANCER and THE DECLINE ! join the Motocultor fun this year and will be filling the empty slots left by DEATH ANGEL and BIRDS IN ROW
Lez Zeppelin
Hellfest 2014 Point&Click
Red Mourning
Nile (Karl Sanders)
Hellfest Vip Crazies! Part 2
Chris Holmes
Hellfest Vip Crazies! Part 1
Blue Pills
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Blood Ceremony
Riff Magazine caught up with Alia O'Brien and Lucas Gadke just before their headlining show with "Spiders", for a claustrophobic and revealing interview.


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Quickened by my attention to what surrounded me
As I sat on one of the pale yellow rounded boulders in the creekbed.
Millennium, seven years, beast, Armageddon — even the word "rapture"
Terms of so-called truth emanating from a final book granted little stature
As we gather today to welcome……….(name of the child) into the world, we recognise our responsibilities towards……….(name of the child), towards each other and the world in which we live.read more
As we leave worship, let us together commit ourselves:
– to give thanks each day for the abundant gift and beauty of life
Concrete certainty
fluid possibility
and stultifies
natural evolution
For deeper love we spread the bread
I won't be full till all are fed
Till every soul has home and bed
The rest of us can't move ahead
Structured for Lent, but practical for any time of the year, this new resource examines the lament psalms for their connections to contemporary experiences. The introduction acquaints the reader with Dr. Walter Brueggemann's analysis of the psalms into the categories of orientation, disorientation, and reorientation. A contemporary psalm/poem for each entry discerns the emotional tenor of the psalms and makes it relevant for the challenges of contemporary life and relationships.read more
One breath; one breath at time.
A breath-on-breath is all we get,
and you cannot take it with you
There is a vitality, a life force, a quickening
That is translated through you into action,
And because there is only one of you in all time,
This expression is unique.
How do you speak with integrity of belief when your audience is seemingly traditional and literal?read more
We are here to praise and enjoy God with body and soul, mind and heart, with song and word, with hands and feet.
We are here to give because of the abundance God has given us, to share with each other, and to receive, because God has created us to depend on each other.
We are here to celebrate the differences that otherwise might divide us: differences of age, of body, of culture, of opinion, of ability, of religious conviction.
We are here to put things in perspective: to celebrate what matters, to laugh about things we take too seriously, to cry about things that truly touch our hearts.
So may it be this morning: Amen!
The central focus for Christian liturgy is the ritual Eucharist. Traditionally Eucharist (which means "thanksgiving") has reenacted the last meal Jesus ate with his followers before the blood sacrifice of his execution at the hands of the Romans, but with the dogmatic interpretation that Jesus died to save sinners from hell in the next life. Twenty-first century progressive Christians are concerned more with living a life of justice-compassion here and now (as Jesus taught) than reconciling with a god that demands blood sacrifice in exchange for a carefree afterlife. What is required is to act with justice-compassion in radical abandonment of self-interest. Suppose that instead of terrorizing ourselves with the Advent of violent judgment, we were to celebrate the Advent of the Christ consciousness; instead of a Eucharist mourning the personal holocaust of Jesus's death, a Eucharist of Ordination, in which we recommit ourselves to the great work of distributive justice-compassion? We have the power, at any moment, to transform the way we live our lives. We can choose not to participate in the retributive system of imperial war and systemic injustice. We can step into the kind of ongoing parallel universe of God's justice-compassion at any moment. We can change our consciousness, change the paradigm in which we live, whenever we have the will to do so. Jesus is not coming again. We are; and when the rare opportunity presents itself, we can break the alabaster jar in remembrance of her.read more


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November 27, 2014
CLARKSBURG, W.Va. (AP) -- West Virginia has seen a decline in overdoses from bath salts since a law making the drug's ingredients illegal went into effect last year.
West Virginia Poison Control Center director Dr. Elizabeth Scharman says 43 cases were reported in 2012. That's down from 250 in 2011.
Scharman tells The Exponent Telegram (http://bit.ly/VETe1H ) that the number of cases fell significantly during the last four months of the year. Thirty one of last year's cases were reported before the end of August.
In April 2012, authorities shut down two stores in Harrison and Upshur counties that were major suppliers of bath salts in north-central West Virginia.
Harrison County Sheriff Albert Marano says police are still seeing bath salts abuse in his county. But it's not as prevalent as it once was.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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HIGHLIGHTS: Day Two vs Derbyshire - LV=CC17-May-2013
See highlights from Day Two of Sussex's clash with Derbyshire in the LV=County Championship as Michael Yardy hit an unbeaten 121, to put Sussex 10..read more »
STUMPS: Ton-up Yardy boosts Sussex16-May-2013
Michael Yardy struck an unbeaten century as Sussex ended day two of their LV=County Championship Division One match against Derbyshire 105 runs ahead ..read more »
SECOND ELEVEN: Second victory over Guernsey16-May-2013
Sussex's Second Eleven made it two wins out of two on there mini tour of Guernsey this week as they beat the Islanders by 88 runs in a 40-ove..read more »
SCCA 2013: 50th Anniversary Gillette Cup Luncheon16-May-2013
Sussex County Cricket Club, through the Sussex Cricket Combined Appeal 2013, are delighted to be hosting a very special luncheon in celebrate the fift..read more »
SECOND ELEVEN: Victory over Guernsey in Twenty2016-May-2013
Sussex's Second Eleven made light work of their hosts Guernsey yesterday as they beat the Islanders by 8 wickets in their Twenty20 match at t..read more »
REPORT: Derbyshire in trouble as Sussex hit back late on16-May-2013
Late wickets put Sussex in charge of their LV=County Championship Division One match at Derby. Wayne Madsen fell for 63 just before stumps as ..read more »
SUSSEX CRICKET LEAGUE: David Bowden elected President15-May-2013
David Bowden has been elected President of the Sussex Cricket League, the senior league in the County. David has been associated with the League ..read more »
SUSSEX CRICKET SPECIAL: Somerset vs Sussex at Taunton15-May-2013
The annual 'Sussex Cricket Special' will be taking place for the away LV=County Championship game against Somerset at Taunton, between Monday 8th ..read more »
PREVIEW: Sussex head to Derbyshire to continue Championship campaign14-May-2013
Sussex return to LV=County Championship action this week as they travel to take on Derbyshire, in a match that begins tomorrow at Derby's Cou..read more »
PRIOR: Matt named England Men's Cricketer of the Year 2012 /201314-May-2013
The ECB lastnight announced that Sussex's Matt Prior had been named as England Men's Cricketer of the Year for 2012/2013. He was honoure..read more »


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my hobby is se x
Set in the picturesque venue of the Munro Boutique hotel in Houghton, Johannesburg, the Mzansi's Sex.
@ Tpaz - you asked for it gal.
Wife collection was not included... darn for Msholozi
Photo 6 - Paul Yarrow is a legend, lol! He appears in the background of TV reporters.
Photo 13 - Very nice...
My hobby is se x
You my perfect match.
@Tpaz we share the same hobby maybe we should hang out sometime
my hobby is se x
my hobby is se x
Ngithanda ukunyobana nami. Would you kindly hook me up or send me your contacts.
They forgot to mention Jacob Zuma....In his spare time he engages in sexual encounters with other ladies he is not married to, have sex with his own wifes, making more babies, lying to parliament, avoiding a motion of no confidence against him to be debated in parliament and using public monies to upgrade his Nkandla home....These are his hobbies
I share the same sentiments. Eish ngiyamzonda lobaba.
The hobby for knitting wollen breasts, I don't understand how it assists breastfeeding women...blond moment!


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Be nice if I could afford lipo, oh well, I'll just lose it the hard way.
That, too. I mean, I don't want to be a twig.... I want to be a bat -flexes muscles-
My motivation is dem eastern euro beauties.... mmmm..... niceeee.
Liebe: BIG MUSCLESSSS.
Mmm. According to some poll we took in Health I'm like the most depressed kid in my class. I just eat more though. When I'm depressed, I mean.


text:
- Product Information
Product Description
NEW LOWER PRICE!! Homer Simpson and his family will add smiles to your guests faces when you decorate your table with our Simpson's paper goods. Perfect for parties of all ages or just for watching The Simpson's on TV. Our Simpson's luncheon napkins are sold 16 to a pack. Please order in increments of 1 pack.
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Black, White & Gold New Year's Eve Party Ideas
Spend New Year's Eve with loved ones when you host a Black, White & Gold New Year's Eve Party with these helpful and creative party tips!
How to Make Your New Year's Eve Party the Easiest Party You've Hosted
Don't sweat the small stuff this New Year's Eve—planning for a party becomes a piece of cake with the help of New Year's Party Kits!
10 Ways to Decorate Your Office or Classroom this Holiday Season
Add Christmas decorations to your office, cubicle or classroom to bring some festivity into the work place this holiday season! Get inspiration from some of these decorating ideas.


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Grand Rapids, MI – The way the 2011 Geneva College women's volleyball season has gone it just seemed as though the Golden Tornadoes would find a way to get things done in the first round of the NCAA Division III regional tournament. Despite a pair of match points on Thursday afternoon, Geneva saw its record breaking season come to an end with a 3-2 loss to ninth ranked Heidelberg in the first round of the NCAA tournament. The Golden Tornadoes set a school record for victories in a season while also capturing the school's first PAC title with an overall record of 27-9 and a conference mark of 17-1.
Playing in its first NCAA regional tournament, Geneva came out firing with a 26-24 victory in the first game of the match. Heidelberg answered back with a 25-14 decision in game two before the Golden Tornadoes again took control with a 25-22 victory in game three. The see-saw match continued with a 25-18 Heidelberg win in game four which set up the fifth and decisive game. Geneva opened up a three-point lead midway through the final game and was handed a match point at 14-13. The Golden Tornadoes could not close out the match but was given another opportunity at 15-14 but once again came up short. Heidelberg capitalized on its only match point opportunity and won game five 17-15.
"It's difficult to think of all the positive things that happened with this team this year right now," said co-head coach Wendy Smith. "This was such a bitter pill to swallow but looking at the entire season how can we be the least bit disappointed. I am so proud of every member of this team and what they accomplished can never be taken away."
Rachel Kuegler, playing in the final match of her Geneva career, posted 12 kills to lead Geneva along with 12 from Ashley Davis. Maggie Bowersox finished the match with nine kills. PAC player of the year Deanna Briody posted 38 assists while senior Brianna Mixter led the team with 34 digs in the final match of her career. "This was an amazing experience for everyone involved with our program," said co-head coach Curt Conser. "Rachel (Kuegler) and Brianna (Mixter) meant so much to this program over the last four years. I guess watching them end their career is the most difficult part of this entire process."
Geneva College is a comprehensive Christian college of the arts, sciences and professional studies. Founded in the tradition of the Reformed Christian faith, Geneva prepares students to serve Christ in all areas of society: work, family and the church. Geneva College's philosophy of education is based on the Foundational Concepts of Christian Higher Education. Geneva is a founding member of the Council for Christian Colleges & Universities (CCCU).
Geneva has an agreement with the Art institute of Pittsburgh, offering students programs in culinary management, interior design, photography, advertising and more.
Upcoming Events


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Mobile Phone News
Mobile phone news, rumours, reviews and deals. Covering all the latest smartphones and feature phones.
Popular Phones:
|Apple iPhone 5S
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Latest mobile phone news:
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18th June, 2013
Google look set to launch the next-gen version of the Nexus 7 in
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17th June, 2013
Looking for a choice of iPhone in a colour other than white or black ?
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Only Samsung know what the specification for the Galaxy S5 will be,
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Samsung show us the reliability testing they perform on the Galaxy S4.
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Samsung Galaxy S4 Active vs Sony Xperia ZL – Which is the Best?
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BlackBerry 10's Facebook App Gets an Overhaul
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Samsung Galaxy S4 Zoom : Smartphone That Doubles As A Digital Camera - Or Vice Versa ?
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Samsung have unveiled the Samsung Galaxy S4 Zoom, which is an Android
ISSENTIEL Luxury Galaxy S4 Case Review
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We review a luxury Galaxy S4 case produced by French company ISSENTIEL.
Apple Stores May Launch An iPhone Trade In Service
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Apple may soon roll out a service whereby customers can trade in
Huawei Ascend P6 World's Thinnest Smartphone : More Details and Images Leaked
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The Huawei Ascend P6 has resurfaced again with a leaked specification
iOS Users Get Ad-Free ITV Player : But It Comes At A Cost
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ITV have launched an premium ad-free version of the ITV Player for
Android Key Lime Pie Delayed : Android 5.0 To Launch On Motorola X Phone ?
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Google look set to unveil Android Key Lime Pie (5.0) in October. Will
Samsung Galaxy S4 vs Samsung Galaxy Note 2 - Which Should You Buy?
14th June, 2013
The Samsung Galaxy S4 is the most powerful handset that Samsung have
iPhone 5S Coming in September with Larger Revolutionary iPhone 6 Launching In 2014
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Apple look set to launch the iPhone 5S this year and the larger
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Apple iOS 7 - an in Depth Look
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The latest version of Apple's mobile operating system has finally
Samsung's Galaxy S5 To Get A New Look and Feel ?
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We wonder if the Samsung Galaxy S5 will differ from the form and feel
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Christina Applegate, Maya Rudolph, Will Arnett
The first season of Up All Night ended on a high note, with Chris (Will Arnett) finally getting to propose to Reagan (Christina Applegate) the way he'd always dreamed. But don't expect everything to be romance and rainbows when the show returns for its sophomore season Thursday at 8:30/7:30c. Creator and executive producer Emily Spivey and producer Tucker Cawley spoke to TVGuide.com about the huge changes coming to this season, which kicks off with some very bad news for Reagan and Ava (Maya Rudolph).
read more
Nikki Blonsky
Smash has tapped another musical veteran for its upcoming season.
Nikki Blonsky, who starred in the 2007 film version of Hairspray, has landed a recurring role in NBC's Broadway drama, according to The Hollywood Reporter. Though there's no word on who she'll be playing, Smash star Wes Brown broke the casting news by tweeting a picture of the actress on set.
Jesse L. Martin
Law & Order alum Jesse L. Martin is heading to NBC's musical series Smash, Deadline reports.
Christina Applegate, Maya Rudolph and Sean Hayes
Six years after saying goodbye to his Emmy-winning "Just Jack" alter ego on Will & Grace, Sean Hayes is returning to NBC. He'll be recurring on Smash and is developing his own comedy series. But first up comes an amusing arc as a passive-aggressive nemesis to Ava (Maya Rudolph) on Up All Night.
"My character, Walter, used to be...
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Sean Hayes
NBC's Smash is hosting a Will & Grace reunion!
Sean Hayes has landed a recurring role on Season 2 of NBC's Broadway drama, the network announced Monday.
There are some big changes coming to NBC's Up All Night.As it heads into its second season, the series is undergoing a major makeover and dropping Ava, the show-within-a-show hosted by Maya Rudolph's character. In moving away from Reagan's workplace, Up All Night will begin to focus more on "smaller, lower-key home stories," according to The Huffington Post.
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The Bachelor
Our top moments of the week:13. The Worst Ex Factor: If you have to ask, "You sure this isn't racist?" three times, chances are, it probably is. On MTV's The Challenge: Battle of the Exes, Emily decides to play a "prank" on her African-American partner and ex-boyfriend, Ty, by smearing chocolate all over her face to do a blackface impersonation of him with Camila, who does her best ...
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text:
IBEROSTAR Rose Hall Suites
Our guests reviewsIBEROSTAR Rose Hall Suites
J Reid says: almost 2 years
"We have enjoyed our Iberostar stay in Jamaica for 4 yrs now. WE take the entire family. The rooms are nice, clean and the staff friendly. The weather has been fabulous during December every yr. We like the food and enjoy the additional restaurants as well. The staff is helpful in all areas. We recommend this resort for families highly."Rating: 8,0
Grace D. From Exton, Pa Usa says: almost 2 years
An amazing Holiday at Rose Hall Suites, Jamaica
"My family, friends and I enjoyed a fabulous vacation at Iberostar Rose Hall Suites from December 28 to January 2. It was our sixth stay at an Iberostar and our first in Jamaica. Iberostar is our favorite all-inclusive and the only one that my family and I trust for a consistently great experience. Our experience at Rose Hall Suites my have been our best. We were warmly greeted upon arrival and I was immediately wished a happy birthday by the front desk. I had requested rooms on a high floor in a quiet location and my request was accommodated. The facilities are simply beautiful and impeccably clean, as we have come to expect from Iberostar. I was welcomed in my room with fruit, a bottle of rum, and tee shirts as loyal guests, and on my birthday, the staff surprised me with a birthday cake in my room. A very nice touch. The highlight of our stay was the New Years Eve Gala dinner and beach party. There were 2013 ice sculptures, hors d'ouevres, and champagne along the way to the gala dinner. The resort outdid itself with an amazing spread and the service and ambiance were perfect. After dinner, there was an outstanding reggae band performing on a stage set up on the beach with two full service bars and stations with rum punch and champagne. Everyone was given hats, masks, noise makers and streamers, and Crazy Kenny energetically led the countdown to 2013. At midnight, there were fireworks on the beach and the party continued to the wee hours. It was surreal ringing in the new year on a beach in Jamaica in such a fun way. We will never forget this wonderful vacation and will be back again for 2014!"Rating: 10,0
Michael From New York says: almost 2 years
Will definitely be back
"Traveled with family for first time to Jamaica. Having never been there before was apprehensive. From the moment we got to the hotel, until we left it was excellent and the best vacation ever. The hotel and grounds are kept impeccable, the staff is extremely friendly and helpful. Our room request was honored and in a great location. The beach was beautiful and well maintained contrary to some negative reviews on trip advisor about it being rocky. The highlight for us, including my 9 & 14 year old daughter was the Star Friends, who definitely were the main reason the trip was great. From the moment my younger daughter met OMG until the New Year's Beach party they made us feel welcome and have fun, even got me doing aerobics at beach which was definitely an interesting sight. The activities kept us having fun and the setting allowed us to fully relax. OMG, Stingray along with Crazy Kenny, Momo, VIP , Special K and Happy Feet had unbelievable energy and always made us feel welcome. Looking forward to our return next year. The only issue was the lack of wifi anywhere but the lobby and slow internet in the room, but I guess it was a good thing that caused me to relax and enjoy it"Rating: 10,0
Tom Arland says: almost 2 years
Overall a very nice vacation.
"Hotel staff from front desk, The Bell Hops Avon and Kevin were excellent. The Star Friends did a great job during the day and nights entertaining us. The facility was extremely clean. Had a very nice stay. The daily maid service and turn down service was excellent. The hotel employees work very hard to satisfy your needs every day. One area that Iberostar should look into was the rental huts on the beach escpecially the one by the volley ball net by the suites. These people were not customer service oriented. We tried to get a snorkel one day at 11:45am we were told to come back after lunch they could not give them out then they were closing for lunch. Also same thing happened to us with the kayaks. Iberostar does a nice job you should not affiliate yourself with the company that manages the rental huts. We did go on a snorkel trip from the hut down by the dock. The woman there was extremely helpful and we were pleased with her service. The hut by the Rose Hall Suites did not work the same way. I can tell you this if those individuals worked for me in the US, I would fire them for poor customer service. I do realize that these employees were not Iberostar employees and it really did show...."Rating: 9,0


text:
Miley Cyrus must not feel she's getting enough attention lately. The singer posted a photo on Instagram of her new "sad kitty" tattoo on the inside of her lip.
The attention-seeking singer also was shown in a photo by Wayne Coyne as she appears to be rolling a joint in Bangerz rolling papers? We wish she'd realize lots of young girls look up to her.read more


text:
Rana Mitter has given an interview for the Institute of Art and Ideas (IAI) on the question of whether we are seeing a changing of the guard, away from American dominance of the world stage, and if so, whether this will open up a power vacuum, and which countries would be looking to step into it.
Ulrike Franke recently contributed to an edited volume called 'Precision Strike Warfare and International Intervention: Strategic, Ethico-Legal and Decisional Implications', edited by Dyson, Tom ; Aslam, Wali ; Rauxloh, Regina ; Aaronson, Mike (Routledge).
Neil MacFarlane was quoted in the Independent (7 November) in an article entitled "Ukraine crisis: Movement of Russian tanks threatens fragile ceasefire, says President Poroshenko".
Adam Roberts spoke to the House of Commons Defence Committee on 29 October about situation in Iraq and Syria and the threat posed by Islamic State in Iraq and the Levant (ISIL).
The Carnegie Endowment for International Peace announced today that the Honorable William J. Burns, U.S. deputy secretary of state, will become its next president on February 4, 2015. Ambassador Burns will be Carnegie's ninth president in its 105-year history.
Next year is the 800th anniversary of Magna Carta. Following the independence referendum in Scotland, calls for a constitutional convention are widespread and growing. Politics in Spires, together with OurKingdom, IPPR and the Department of Politics at the University of Southampton, are hosting the Great Charter Convention – an open, public debate on where arbitrary power lies in the UK today and how we should contest and contain it. What would a new Magna Carta say, and what could a new constitutional settlement for Britain look like?
Gwen Sasse has published a further piece for Carnegie Europe (22 October) on how the upcoming parliamentary elections in Ukraine might only deepen existing divisions.
In January, Rasmus Kleis Nielsen will start work as Director of Research and Development at the Reuters Institute for the Study of Journalism (a research centre that is part of the Department of Politics and International Relations).
Neil MacFarlane was interviewed by Deutsche Welle (24 October) for an article entitled 'Terror attacks threaten Canada's multicultural project', which explored the possible cultural ramifications of the recent shootings in Montreal and Ottowa.
Congratulations to Catherine de Vries, who has been given the 2014 Emerging Scholar Award by the Elections, Public Opinion and Voting Behavior section of the American Political Science Association. She shares this award with Dan Hopkins of Georgetown University.


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Dirndl On Intel's Sandy (Bridge) Is Hot
Published on 10 June 2011 08:27 AM EDT
Written by
Michael Larabel
Free Software
18 Comments
To some frustration,
the big software announcement that's codenamed Dirndl
hasn't yet hit wire. I'm told the company is deciding within the next couple of hours whether they want to issue a press release on a Friday or hold off until next week, but regardless of the day of week it will generate a lot of attention due to this game-changing move. Soon as I hear it's hit the wire, a four-page Phoronix article is in the queue.
Fortunately, at least, the company doesn't seem to object to these hints being dropped while using the Phoronix codename of Dirndl. Phoronix readers are certainly interested in what's being open-sourced with there being pages of speculations in the forums, which may or may not be correct. The company in question may offer something "special" to Phoronix readers if the release is pushed back to next week, but we'll see how today pans out.
Yesterday evening I showed off
the Dirndl performance on an AMD Opteron
, which was fantastic compared to the status quo. This morning here are some more benchmarks showing what Intel's Sandy Bridge CPU looks like in a Dirndl. In particular, a Core i5 2520M.
Sandy's quite good in a Dirndl, as expected. Now to wait a few hours and can hopefully then blow the top on this story... The wait should at least be worth it for any serious enthusiasts and software developers. With these delays, at least plenty of Bavarian references and jokes can be made out of the codename to pass the time. In the meantime, I'll see if Mesa / Gallium3D can fit into a Dirndl. More
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Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae.
ABSTRACT Sixty-five clinical isolates of Streptococcus pneumoniae, all collected in Italy between 1999 and 2002 and resistant to both tetracycline (MIC, >or=8 microg/ml) and erythromycin (MIC, >or=1 microg/ml), were investigated. Of these strains, 11% were penicillin resistant and 23% were penicillin intermediate. With the use of the erythromycin-clindamycin-rokitamycin triple-disk test, 14 strains were assigned to the constitutive (cMLS) phenotype of macrolide resistance, 44 were assigned to the partially inducible (iMcLS) phenotype, 1 was assigned to the inducible (iMLS) phenotype, and 6 were assigned to the efflux-mediated (M) phenotype. In PCR assays, 64 of the 65 strains were positive for the tetracycline resistance gene tet(M), the exception being the one M isolate susceptible to kanamycin, whereas tet(K), tet(L), and tet(O) were never found. All cMLS, iMcLS, and iMLS isolates had the erythromycin resistance gene erm(B), and all M phenotype isolates had the mef(A) or mef(E) gene. No isolate had the erm(A) gene. The int-Tn gene, encoding the integrase of the Tn916-Tn1545 family of conjugative transposons, was detected in 62 of the 65 test strains. Typing assays showed the strains to be to a great extent unrelated. Of 16 different serotypes detected, the most numerous were 23F (n = 13), 19A (n = 10), 19F (n = 9), 6B (n = 8), and 14 (n = 6). Of 49 different pulsed-field gel electrophoresis types identified, the majority (n = 39) were represented by a single isolate, while the most numerous type included five isolates. By high-resolution restriction analysis of PCR amplicons with four endonucleases, the tet(M) loci from the 64 tet(M)-positive pneumococci were classified into seven distinct restriction types. Overall, a Tn1545-like transposon could reasonably account for tetracycline and erythromycin resistance in the vast majority of the pneumococci of cMLS, iMcLS, and iMLS phenotypes, whereas a Tn916-like transposon could account for tetracycline resistance in most M phenotype strains.
- [Show abstract] [Hide abstract]
ABSTRACT: As with other widely used antibacterials, the abundant use of macrolides for management of ambulant infections has promoted emergence of resistance against them. Ketolides are structurally related to macrolides and were developed to overcome macrolide resistance, while sharing pharmacodynamic and pharmacokinetic characteristics. However, until now, there have been no comprehensive reviews of the comparative pharmacokinetics of macrolides and ketolides. This article reviews the pharmacokinetic parameters in plasma and relevant tissues of telithromycin, the only approved ketolide, and cethromycin, which is currently in phase III of clinical development. For comparison, the 14-membered macrolides clarithromycin and roxithromycin and the 15-membered azalide azithromycin were chosen as representatives of their class. While telithromycin achieves higher plasma concentrations than cethromycin, both antimicrobials display comparable elimination half-lives and clearance. Repeated dosing rarely influences the pharmacokinetic parameters of ketolides. Despite substantially higher maximum plasma concentrations and area under the plasma concentration-time curve (AUC) values of telithromycin, the higher antimicrobial activity of cethromycin leads to similar ratios between the AUC from 0 to 24 hours (AUC(24)) and the minimum inhibitory concentration (MIC) for relevant pathogens, suggesting comparable antimicrobial activity of both antimicrobials in plasma. Although telithromycin and cethromycin show plasma-protein binding of 90%, they have excellent tissue penetration, as indicated by volumes of distribution of about 500 L and high intracellular concentrations. Besides enhancing killing of intracellular pathogens, the high concentrations of macrolides, azalides and ketolides in leukocytes have been associated with increased delivery of the antimicrobial agent to the site of infection. Although telithromycin has been shown to accumulate in alveolar macrophages and epithelial lining fluid by 380- and 15-fold, respectively (relative to plasma concentrations), its concentration in the interstitium of soft tissues is comparable to the free fraction in plasma. Thus the pharmacokinetics of ketolides may help to explain their good activity against a wide range of respiratory tract infections, although pharmacokinetic/pharmacodynamic calculations based on plasma pharmacokinetics would indicate only minor activity against pathogens except streptococci. In contrast, AUC(24)/MIC ratios achieved in soft tissue may be considered insufficient to kill extracellular pathogens causing soft tissue infections, except for Streptococcus pyogenes. Although ketolides and macrolides share relevant pharmacokinetic properties, the pharmacokinetics of both antimicrobial classes are not considered interchangeable. With a volume of distribution similar to that of azithromycin but plasma concentrations and an elimination half-life reflecting those of clarithromycin, the pharmacokinetics of ketolides may be considered 'intermediate' between those of macrolides and azalides. Thus the pharmacokinetics of ketolides can be considered similar but not identical to those of macrolides.Clinical Pharmacokinetics 02/2009; 48(1):23-38. · 5.49 Impact Factor
Article: Macrolide, lincosamide and tetracycline susceptibility and emm characterisation of invasive Streptococcus pyogenes isolates in Israel.[Show abstract] [Hide abstract]
ABSTRACT: Group A beta-haemolytic streptococcus (GAS) causes a variety of infections, including life-threatening illnesses. Although the species is uniformly penicillin susceptible, resistance to other antibiotics is becoming more common. We studied the prevalence of resistance and associated factors in a nationwide, prospective, population-based study of invasive infections in Israel. Isolates were collected in collaboration with 24 hospitals in Israel during 1996-1999. Minimal inhibitory concentrations (MICs) of erythromycin (ERY), clindamycin (CLI) and tetracycline (TET) were determined as well as ERY and TET resistance phenotypes and genotypes. Five hundred isolates were examined: 136 (27.2%) were not susceptible to TET, 10 (2.0%) to ERY and 5 (1%) to CLI. ERY resistance was associated with emm types 12 and 83 (P<0.001 for both). MICs of TET had a bimodal distribution distinguishing sensitive and resistant populations. Non-susceptibility to TET was mainly due to the presence of tet(M) and was associated with T types 3, 3/13/B3624 and 9 and emm types 9, 33, 64, 73, 74, 76, 77 and 83. TET susceptibility was associated with T types 1, 2 and 11, emm types 1-4, 11, 12, 22, 26 and 75 and the presence of speA and speC. In Israel, resistance of invasive GAS isolates to ERY remains low and is associated with specific T and emm types, as is TET resistance. TET resistance is less frequent than previously reported in Israel and is associated with a lower prevalence of speA and speC.International Journal of Antimicrobial Agents 11/2006; 28(4):313-9. · 4.42 Impact Factor
Article: Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance.[Show abstract] [Hide abstract]
ABSTRACT: Antibiotic-resistant Gram-positive bacteria are responsible for morbidity and mortality in healthcare environments. Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus and Streptococcus pneumoniae can all exhibit clinically relevant multidrug resistance phenotypes due to acquired resistance genes on mobile genetic elements. It is possible that clinically relevant multidrug-resistant Clostridium difficile strains will appear in the future, as the organism is adept at acquiring mobile genetic elements (plasmids and transposons). Conjugative transposons of the Tn916/Tn1545 family, which carry major antibiotic resistance determinants, are transmissible between these different bacteria by a conjugative mechanism during which the elements are excised by a staggered cut from donor cells, converted to a circular form, transferred by cell-cell contact and inserted into recipient cells by a site-specific recombinase. The ability of these conjugative transposons to acquire additional, clinically relevant antibiotic resistance genes importantly contributes to the emergence of multidrug resistance.FEMS microbiology reviews 06/2011; 35(5):856-71. · 10.96 Impact Factor
Page 1
Antimicrob. Agents Chemother.
Pietro E. Varaldo
Maria P. Montanari, Ileana Cochetti, Marina Mingoia and
Streptococcus pneumoniae
Erythromycin-Resistant Strains of
of Tetracycline- and
Phenotypic and Molecular Characterization
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, July 2003, p. 2236–2241
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
Vol. 47, No. 7
Phenotypic and Molecular Characterization of Tetracycline- and
Erythromycin-Resistant Strains of Streptococcus pneumoniae
Maria P. Montanari, Ileana Cochetti, Marina Mingoia, and Pietro E. Varaldo*
Department of Microbiology and Biomedical Sciences, University of Ancona
Medical School, 60131 Ancona, Italy
Received 17 December 2002/Returned for modification 17 March 2003/Accepted 15 April 2003
Sixty-five clinical isolates of Streptococcus pneumoniae, all collected in Italy between 1999 and 2002 and re-
sistant to both tetracycline (MIC, >8 ?g/ml) and erythromycin (MIC, >1 ?g/ml), were investigated. Of these
strains, 11% were penicillin resistant and 23% were penicillin intermediate. With the use of the erythromycin-
clindamycin-rokitamycin triple-disk test, 14 strains were assigned to the constitutive (cMLS) phenotype of
macrolide resistance, 44 were assigned to the partially inducible (iMcLS) phenotype, 1 was assigned to the
inducible (iMLS) phenotype, and 6 were assigned to the efflux-mediated (M) phenotype. In PCR assays, 64 of
the 65 strains were positive for the tetracycline resistance gene tet(M), the exception being the one M isolate
susceptible to kanamycin, whereas tet(K), tet(L), and tet(O) were never found. All cMLS, iMcLS, and iMLS
isolates had the erythromycin resistance gene erm(B), and all M phenotype isolates had the mef(A) or mef(E)
gene. No isolate had the erm(A) gene. The int-Tn gene, encoding the integrase of the Tn916-Tn1545 family of
conjugative transposons, was detected in 62 of the 65 test strains. Typing assays showed the strains to be to a
great extent unrelated. Of 16 different serotypes detected, the most numerous were 23F (n ? 13), 19A (n ? 10),
19F (n ? 9), 6B (n ? 8), and 14 (n ? 6). Of 49 different pulsed-field gel electrophoresis types identified, the
majority (n ? 39) were represented by a single isolate, while the most numerous type included five isolates. By
high-resolution restriction analysis of PCR amplicons with four endonucleases, the tet(M) loci from the 64
tet(M)-positive pneumococci were classified into seven distinct restriction types. Overall, a Tn1545-like trans-
poson could reasonably account for tetracycline and erythromycin resistance in the vast majority of the
pneumococci of cMLS, iMcLS, and iMLS phenotypes, whereas a Tn916-like transposon could account for
tetracycline resistance in most M phenotype strains.
In Streptococcus pneumoniae, tetracycline resistance is pre-
dominantly due to ribosomal protection, i.e., the production of
cytoplasmic proteins—-encoded by tet(M) or, less often, other
tet genes—capable of interacting with the ribosome and mak-
ing it insensitive to tetracycline inhibition (3, 38). An efflux-
mediated mechanism reducing the intracellular tetracycline
concentration to subtoxic levels is less common in streptococci,
where this mechanism is due to membrane proteins encoded
by the gene tet(K) or tet(L) (3).
Pneumococcal resistance to macrolides is due to either tar-
get site modification or active efflux (40). The former, preva-
lent mechanism usually depends on a posttranscriptional,
methylase-mediated modification of 23S rRNA encoded by the
erm(B) gene (19, 40). erm(B)-associated coresistance to mac-
rolide, lincosamide, and streptogramin B (MLS) antibiotics
can be expressed either constitutively, with high-level resis-
tance to all MLS antibiotics (cMLS phenotype), or inducibly
(iMLS phenotype). More often, pneumococcal strains appear
inducibly resistant to only 16-membered macrolides and con-
stitutively resistant to lincosamides (iMcLS phenotype) (22).
Another methylase first described (31) and then found to be
extensively present (15, 17) in Streptococcus pyogenes, medi-
ated by a gene originally called erm(TR) and now designated
erm(A) according to current nomenclature (30), has only oc-
casionally been reported in S. pneumoniae (2, 35). Recently,
mutations in 23S rRNA or ribosomal proteins leading to mac-
rolide resistance in clinical isolates of S. pneumoniae have also
been described (10, 37). A macrolide efflux mechanism, first
demonstrated with S. pneumoniae and S. pyogenes and then
with other streptococci, is associated with a resistance pattern
(M phenotype) characterized by low-level resistance to only
14- and 15-membered macrolides among MLS antibiotics (34).
M phenotype resistance is mediated by mef genes, two variants
of which, mef(A) and mef(E)—originally discovered in S. pyo-
genes (4) and S. pneumoniae (36), respectively—have 90%
identity (36) and have been regarded as a single gene class
designated mef(A) (30). However, the two variants have re-
cently been shown to be carried by different genetic elements
in S. pneumoniae (9), and due to a number of important dif-
ferences in the properties of mef(A)- and mef(E)-carrying
pneumococci (9, 22), it has been recommended that the dis-
tinction between the two genes be maintained. A novel eryth-
romycin efflux system, not associated with mef(A) or with other
known macrolide efflux genes, has lately been described in
erm(A)-positive strains of S. pyogenes with inducible, high-level
resistance to erythromycin (14). However, its presence in S.
pneumoniae and other streptococci has not yet been addressed.
In streptococci, drug resistance determinants occur more
frequently on conjugative transposons than on plasmids. In
particular, in S. pneumoniae the association of erythromycin
resistance and tetracycline resistance may be due to Tn1545
and related conjugative transposons, which encode erythromy-
cin resistance via erm(B) and tetracycline resistance via tet(M)
* Corresponding author. Mailing address: Department of Microbi-
ology and Biomedical Sciences, University of Ancona Medical School,
Via Ranieri, Monte d'Ago, 60131 Ancona, Italy. Phone: 39 071
2204694. Fax: 39 071 2204693. E-mail: firstname.lastname@example.com.
on May 29, 2013 by guest
Downloaded from
Page 3
and also kanamycin resistance via aphA3 (8). These transpo-
sons belong to a larger class of conjugative transposons, typi-
cally represented by Tn916, which encode tet(M)-mediated
resistance to tetracycline but not resistance to erythromycin or
kanamycin (6). An integrase gene usually called int-Tn, related
to the second of the 24 open reading frames of Tn916, is
characteristic of the Tn916-Tn1545 family of conjugative trans-
posons (6).
In this study, a collection of clinical S. pneumoniae isolates
resistant to both tetracycline and erythromycin were typed and
investigated for a number of phenotypic and genotypic char-
acteristics inherent to either resistance.
Bacterial strains. Sixty-five clinical isolates of S. pneumoniae, all resistant to
both tetracycline (MIC, ?8 ?g/ml) and erythromycin (MIC, ?1 ?g/ml), were
tested. All strains, collected from several Italian laboratories between 1999 and
2002, were isolated from upper respiratory tract specimens (the vast majority),
sputum, blood, or cerebrospinal fluid. Strain identification was confirmed in our
laboratory by conventional tests, such as susceptibility to optochin and solubility
in bile, and by the API system (Biome ´rieux, Marcy-l'Etoile, France).
Antibiotics and susceptibility tests. Tetracycline, erythromycin, minocycline,
and penicillin were purchased from Sigma Chemical Co., St. Louis, Mo. Broth
microdilution MICs were determined and MIC breakpoints of tetracycline and
erythromycin were interpreted as recommended by the National Committee for
Clinical Laboratory Standards (24). Mueller-Hinton II broth (BBL Microbiology
Systems, Cockeysville, Md.) supplemented with 3% lysed horse blood was used
as the test medium. The inoculum was 5 ? 105CFU/ml, and S. pneumoniae
ATCC 49619 was used for quality control. Kanamycin susceptibility was deter-
mined by a standard agar diffusion test (25) using 30-?g commercial disks (Oxoid
Ltd., Basingstoke, United Kingdom) with the following zone diameter break-
points: susceptible, ?18 mm; intermediate, 14 to 17 mm; resistant, ?13 mm.
Determination of the macrolide resistance phenotype. Test strains were as-
signed to the constitutive (cMLS), the partially inducible (iMcLS), the inducible
(iMLS), or the efflux-mediated (M) macrolide resistance phenotype on the basis
of the triple-disk (erythromycin plus clindamycin and rokitamycin) test, as de-
scribed previously (23).
Gene detection by PCR. Tetracycline resistance genes tet(K) and tet(L) were
detected by using the primer pairs described by Trzcinski et al. (39), and tet(M)
and tet(O) were detected by using those described by Corso et al. (7) and Olsvik
et al. (26), respectively. Erythromycin resistance genes erm(A) and erm(B) were
detected by using the oligonucleotide primers designated III8and III10by Sep-
pa ¨la ¨ et al. (31) and the primer pair developed by Sutcliffe et al. (33), respectively.
The mef gene was detected by using the primer pair described by Sutcliffe et al.
(33); mef(A) and mef(E) were then distinguished by PCR restriction fragment
length polymorphism analysis of the 348-bp amplicon with BamHI (New En-
gland Biolabs, Beverly, Mass.), which has no restriction site in mef(E) and one in
mef(A), generating two fragments of 284 and 64 bp (22). The integrase gene
int-Tn, associated with the Tn916-Tn1545 family of conjugative transposons, was
detected by using the primer pair described by Poyart-Salmeron et al. (27). DNA
preparation and amplification and electrophoresis of PCR products were carried
out by adapting established methods (16) to the procedures described for the
individual primer pairs.
Serotyping. All isolates were serotyped by the capsular swelling test using
specific antisera (Statens Seruminstitut, Copenhagen, Denmark). Serotypes were
indicated with conventional capsular type designations.
PFGE. SmaI macrorestriction fragment patterns were analyzed by pulsed-field
gel electrophoresis (PFGE); macrorestriction and PFGE were performed, and
the relevant patterns were analyzed and compared as recently described else-
where (29). For clusters with at least two isolates, types were designated with
lowercase letters in order of size.
HRRA. High-resolution restriction analysis (HRRA) of the tet(M) gene was
carried out essentially as described by Doherty et al. (12). Briefly, a 10-?l aliquot
of the PCR product obtained by using the primer pair described by Corso et al.
(7) from each tet(M)-positive isolate was digested with the following restriction
endonucleases: AciI, MseI, RsaI, and TaqI (New England Biolabs). Restriction
fragments were separated by agarose (4%) gel electrophoresis and visualized by
staining with ethidium bromide. The molecular size marker (100-bp DNA lad-
der) was from M-Medical Genenco, Florence, Italy. Each restriction pattern
yielded by each endonuclease was assigned a number; restriction genotypes were
determined on the basis of the combined restriction patterns of all four enzymes
and lettered with capitals in order of size.
Antibiotic susceptibility. The distribution of MICs of tetra-
cycline, erythromycin, and penicillin for the 65 tetracycline-
and erythromycin-resistant isolates of S. pneumoniae is sum-
marized in Table 1. Forty-three strains were susceptible to
penicillin (MIC, ?0.12 ?g/ml), 15 were intermediate, and sev-
en were resistant (the MIC for five of these strains was 2 ?g/ml
and that for the other two was 4 ?g/ml). All the strains but one
were resistant to kanamycin according to the results of the disk
Macrolide resistance phenotypes. On the basis of the eryth-
romycin-clindamycin-rokitamycin triple-disk test, 14 of the 65
test strains were assigned to the cMLS phenotype, 44 were
assigned to the iMcLS phenotype, 1 was assigned to the iMLS
phenotype, and 6 were assigned to the M phenotype. These
findings, together with the ranges of MICs of erythromycin, are
summarized in Table 2.
Genotypic strain characterization. As shown in Table 3, the
tetracycline resistance genes tet(K), tet(L), and tet(O) were not
found. In contrast, 64 of the 65 test strains were positive for
tet(M), the exception being one M phenotype isolate (MIC of
penicillin, 0.25 ?g/ml; MIC of tetracycline, 16 ?g/ml; MIC of
minocycline, 0.25 ?g/ml; MIC of erythromycin, 16 ?g/ml), the
only isolate susceptible to kanamycin, which was negative for
all four tetracycline resistance genes tested. All cMLS and
iMcLS isolates as well as the iMLS isolate had the erm(B)
gene, and all six M phenotype isolates had the mef gene [four
with mef(E) and two with mef(A)]. The mef gene was also
found in six isolates with the erm(B) gene: five [four with
mef(E) and one with mef(A)] of the iMcLS phenotype and one
[with mef(A)] of the cMLS phenotype. No isolate had the
erm(A) gene. Of the 59 strains carrying both tet(M) and
erm(B), i.e., all the strains of the cMLS, iMcLS, and iMLS
phenotypes, 57 were also positive for the int-Tn gene (all ex-
TABLE 1. Distribution of MICs of tetracycline, erythromycin, and
penicillin for 65 tetracycline- and erythromycin-resistant
isolates of S. pneumoniae
No. of strains inhibited by MIC (?g/ml) ofa:
?0.12 0.12 0.250.524816 3264128
5 13 15 13
1 3 1
5 2
aNo strain was inhibited by a MIC of 1 ?g/ml.
TABLE 2. Macrolide resistance phenotypes of 65 tetracycline- and
erythromycin-resistant isolates of S. pneumoniae
Macrolide resistance
No. (%) of
Range of MICs (?g/ml)
of erythromycin
14 (21.6)
44 (67.7)
1 (1.5)
6 (9.2)
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cept a cMLS isolate and an iMcLS isolate). Of the six M
phenotype strains, which carried mef(A) or mef(E) as the only
erythromycin resistance determinant, the five with the tet(M)
gene were also int-Tn positive, whereas the isolate lacking
tet(M) as well as the other tetracycline resistance genes tested
was also int-Tn negative.
Typing. Sixteen different serotypes, of which 11 were repre-
sented by at least two isolates, were detected. The most nu-
merous was 23F (n ? 13), followed by 19A (n ? 10), 19F (n ?
9), 6B (n ? 8), and 14 (n ? 6).
Forty-nine PFGE types, of which 10 were represented by at
least two isolates, were detected. Type a, the most numerous,
included five isolates.
The distribution of serotypes and PFGE types among the 65
erythromycin- and tetracycline-resistant S. pneumoniae isolates
and their associations with the characteristics described above
(macrolide resistance phenotypes, tetracycline and erythromy-
cin resistance genes, and the int-Tn gene) are summarized in
Table 3.
Restriction types of the tet(M) gene. With HRRA of allelic
variation within tet(M), endonucleases MseI and TaqI each
yielded consistently the same fingerprinting profiles from the
PCR amplicons of all strains, whereas AciI and RsaI produced
five and two distinct profiles, respectively (Fig. 1). Altogether,
the tet(M) loci from the 64 tet(M)-positive pneumococci ana-
lyzed fell into seven restriction types (A to G). Their distribu-
tion is reported in Table 3. Over half (31 of 59) of the strains
with the erm(B) gene (cMLS, iMcLS, and iMLS phenotypes)
had restriction type A, whereas four of the five strains with the
mef gene (M phenotype) exhibited restriction type B. Restric-
tion types A and B are shown in Fig. 2.
In clinical isolates of S. pneumoniae, tetracycline resistance
is frequently associated with erythromycin resistance. In one
large U.S. survey carried out from 1999 to 2000, ?60% of
multiresistant pneumococci exhibiting erythromycin resistance
were also resistant to tetracycline (11); in Europe, associations
of ?80% in erythromycin-resistant pneumococci isolated in
Spain (32) and Italy (21) have recently been reported. This
association may reflect the widespread presence in pneumo-
coccal populations of transposons, typified by Tn1545, thought
to result from the insertion over time of resistance deter-
minants, such as erm(B) for erythromycin and aphA3 for
kanamycin, into primitive gram-positive conjugative trans-
posons carrying tet(M) and the integrase gene int-Tn, typified
by Tn916 (3, 6).
Among the 65 tetracycline- and erythromycin-resistant clin-
ical strains of S. pneumoniae investigated in this study, the
presence of Tn1545-like transposons could reasonably account
for tetracycline and erythromycin resistance in the vast major-
ity (at least 57 of 59) of the strains of the cMLS, iMcLS, and
iMLS phenotypes, i.e., those sharing tet(M), erm(B), kanamy-
cin resistance, and the int-Tn gene. The remaining two isolates
shared tet(M), erm(B), and kanamycin resistance but were
int-Tn negative. However, tet(M) was also associated with
int-Tn in five of the six strains of the M phenotype, i.e., strains
lacking erm genes and expressing erythromycin resistance due
to mef-mediated active efflux. Unlike erm(B) in pneumococci
with constitutive or inducible MLS resistance, the mef gene in
M phenotype pneumococci is not known to be linked to tetra-
cycline resistance, which in these strains could be due to a
Tn916-like transposon. Similar findings—i.e., M phenotype
TABLE 3. Macrolide resistance phenotypes and their association with tetracycline and erythromycin resistance genes, the int-Tn gene,
serotypes, PFGE types, and restriction types of the tet(M) gene in 65 tetracycline- and erythromycin-resistant isolates of S. pneumoniae
phenotype (n)
Resistance genea
No. of
(no. of strains)b
PFGE type(s)
(no. of strains)b,c
Restriction type of tet(M)
loci (no. of strains)b,d
tet(M)erm(B)mef(A) mef(E)
cMLS (14)
b (2), d (2), c, Ost (7) A (4), E (3), G (3), B (2)
iMcLS (44)
a (4), c (2), e (2), f (2),
i (2), b, h, j, Ost (23)
a, b, g, h
iMLS (1)
1 23FOstA
j, Ost (3)
atet(K), tet(L), tet(O), and erm(A) were not detected in any test strain. ?, present; ?, absent.
bThe number of strains is indicated for types represented by more than one strain.
cOst, one-strain type.
dRestriction profiles were as follows (different profiles yielded by the same endonucleases are distinguished by subscript numerals): A, RsaI1, MseI, TaqI, AciI1; B,
RsaI2, MseI, TaqI, AciI2; C, RsaI2, MseI, TaqI, AciI3; D, RsaI1, MseI, TaqI, AciI3; E, RsaI1, MseI, TaqI, AciI4; F, RsaI2, MseI, TaqI, AciI1; G, RsaI1, MseI, TaqI, AciI5.
eThis strain was the only kanamycin-susceptible isolate and was also found to be susceptible to minocycline.
on May 29, 2013 by guest
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pneumococci carrying mef(A) or mef(E), tet(M), and int-Tn—
have recently been reported in Spain (32) and Scotland (1).
Interestingly, the same tet(M) allele (type II) was identified by
HRRA in four of our five M phenotype strains carrying mef(A)
or mef(E), tet(M), and int-Tn. In contrast, the prevalent tet(M)
allele (type I) of the seven detected in the 64 tet(M)-positive
pneumococci was identified in isolates of all phenotypes
(cMLS, iMcLS, and iMLS) with erm(B)-mediated erythromy-
cin resistance but in no strain with mef(A) or mef(E)-mediated
resistance (M phenotype). The sixth M phenotype pneumo-
coccus was the only test strain susceptible to kanamycin and
the only one lacking tet(M). Since this strain was also negative
for tet(O), tet(K), and tet(L), it is possible that some less com-
mon tet gene capable of conferring tetracycline resistance on
streptococci (3, 5) was involved; however, its susceptibility to
minocycline suggests an efflux mechanism (3).
It is worth noting that in none of our tetracycline- and
erythromycin-resistant S. pneumoniae isolates did we detect
the tet(O) gene, whose presence in this species has occasionally
been reported in limited numbers of South African (41), North
FIG. 1. Different fingerprinting profiles obtained by digesting the tet(M) amplicons from 64 tet(M)-positive pneumococci with four endonucle-
ases. Lane M, molecular size marker (100-bp ladder). Lane A, undigested tet(M) amplicon. Lanes 1a to 1e, different AciI profiles (AciI1to AciI5).
Lanes 2a and 2b, different RsaI profiles (RsaI1and RsaI2). Lane 3, MseI profile. Lane 4, TaqI profile.
FIG. 2. HRRA patterns of two tet(M)-positive pneumococci with restriction types A and B. Lane M, molecular size marker (100-bp ladder).
Lane A, undigested tet(M) amplicon of the strain exhibiting restriction type A; lanes A1 to A4, restriction profiles yielded by endonucleases AciI,
RsaI, MseI, and TaqI, respectively. Lane B, undigested tet(M) amplicon of the strain exhibiting restriction type B; lanes B1 to B4, restriction profiles
yielded by endonucleases AciI, RsaI, MseI, and TaqI, respectively.
on May 29, 2013 by guest
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European stocks and the euro were lifted by talk of euro zone bonds by European Commission President Jose Manuel Barroso.
European stock markets surged and the euro rose on comments by European Commission President Jose Manuel Barroso about a proposal for euro zone bonds aimed at tackling the region's debt crisis.
The euro increased the most in a week against the dollar after Barroso said he is close to proposing options for euro bond sales, the Irish Times reports. European markets had declined after Moody's downgraded French banks Societe Generale and Credit Agricole due to their exposure to Greece's debt, but were lifted by the talk of euro bonds, Reuters says.
More from GlobalPost: Headed toward break-up in the euro zone
Barroso this morning also called for closer political integration in the EU and a "new federalist movement" to confront the challenge of the debt crisis to the union.
"This is a fight for the jobs and prosperity of families in all our member states," he said, the Irish Times reports. "This is a fight for the economic and political future of Europe. This is a fight for what Europe represents in the world. This is a fight for European integration itself."
Barroso called the euro zone debt crisis "the most serious challenge of a generation," the BBC reports.
He said he would urge the 17 euro zone nations to issue joint bonds that would allow them to borrow money collectively.
But while euro bonds have been backed by Italian Finance Minister Giulio Tremonti and investor George Soros, Germany has repeatedly opposed the idea, and a political battle may lie ahead, the BBC says.


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MOST government programs begin with good intentions. Advocates can passionately make a case for greater funding in any number of areas. These abstract arguments are compelling — until they crash upon the rocky shoals of fiscal reality.
The demand for government spending in Oklahoma continues to outpace the ability of taxpayers to fund programs. Restraint is necessary. Cuts to some programs may be unavoidable if lawmakers wish to boost funding for others.
Legislation creating a special account to fund cost-of-living adjustments (COLAs) for state pension beneficiaries is an example.
Although the bill is advancing, increased benefit payments are unlikely because the cost is far more than the state can afford. A 2 percent COLA increase for all retirees would cost $325 million. Lawmakers have "only" $213 million more than a year ago. Therefore, a COLA isn't possible without cutting other programs, even if no other spending needs existed. And those needs do exist.
For the first eight months of the fiscal year, the Department of Corrections has a deficit of $13.4 million, much of it driven by inmate growth. The number of staff positions the agency can afford to fill is far below the number authorized, leading to double shifts and increased danger for correctional officers. The agency wants a budget increase of nearly $67 million and a supplemental appropriation of nearly $6.4 million to cover the cost of unfunded, mandated increases to private contractors.
The state Department of Education wants a $289 million increase to pay for implementing reforms and to allow local districts to boost teacher pay, as well as restore many cuts made during the recession. So if lawmakers considered authorizing a COLA for state retirees, it would likely come at the expense of K-12 spending.
Continue reading this story on the...
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It was nice last week seeing the pictures from my visit to the quarry with my personal trainer Trevor Tieche of Bodi N Balance.
I finished out with a good week. I was weighed and measured on Friday and the hard work and determination are paying off. I lost 2 pounds and several inches since my last weigh-in three weeks ago.
This past week was yet another week in which I feel as though I worked very hard, but haven't seen the results I'd been hoping to achieve.
Circulation Assistant
Public Transit Administrator
Online Contact Form419-625-5500800-466-1243314 West Market St.Sandusky, OH 44870


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The Lodge at Mountain Village Condo Rental Photos and Description
Condo, 1 Bedroom + Convertible bed(s), 2 Baths, (Sleeps 2-5)
The Loft condo located in Park City Mountain Resort offers the complete Park City experience. Staying right on the resort allows you to walk out your front door and hit the mountain, enjoy a meal, or go shopping.
Sun or snow the Loft condo can accommodate with activities for every season including skiing, snowboarding, hiking, biking, mountain roller coasters, etc and it's all right out your front door!
If the resort entertainment just isn't enough take advantage of Park City's free Transit System which can take you to historic Main Street where fabulous dining, shopping, and night life await.
Or you can experience your vacation condo to its fullest and cook up a feast in the newly updated kitchen or relax in the jacuzzi tub in the recently remodeled, spa-like, bathrooms. Fun times and memories await you at the Loft condo in Park City, Utah. Enjoy the view!
Why Rent from us?
DISCOUNTED AIRPORT TRANSPORTATION - Our guests receive a discount off of published rates with our partnered transportation company, Shuttle Park City.
DISCOUNTED EQUIPMENT RENTAL - We have built a relationship with Aloha Ski Rentals and our guests receive discounts on rentals, retail merchandise and are eligible for free overnight storage at PCMR.
LOCAL EXPERTISE - We are perfectly positioned to provide the best care possible to our guests, right in Park City!
ATTENTION TO DETAIL - We are able to personally look after each one and provide the best service to our guests.
BEST ACCOMMODATIONS - Because we are small, you can be assured that we're offering only the best options for you and your group or family!
COMPETITIVE RATES - We carefully review our competition each season to ensure that our rates are fair and extremely competitive.
PREMIUM LINENS AND TOWELS - The beds are all made with high thread count linens, plenty of nice pillows and duvet covers on the comforters that are cleaned between every reservation so you can feel as comfortable as you do at home.
AMENITIES - Your condo will of course have spa quality soap, shampoo, conditioner, and lotion in each bathroom when you arrive, so you can feel comfortable immediately.
COMPLIMENTARY COFFEE - Our guests will arrive with a bag of fresh roasted coffee from Silver Bean Coffee, a local premium roaster. We also include real creamer, sugar, sweetener, hot chocolates, and an assortment of hot teas in the unit for you to enjoy during your stay.
GROCERY SERVICE - An optional grocery service is available to our guests who would like to have some essentials in the unit when they arrive. We purchase groceries at the local stores within 24 hours of your arrival, and purchase name brand items as much as possible.
Keywords: Condominium
- Suitability:
- children welcome
- non smoking only
- pets not allowed
- suitable for elderly or infirm
- wheelchair accessible
Guestbook comments from the owner
We really enjoyed our stay in Park City and at your condo in particular. While initially a bit unsure about the space, the accommodations were very nicely appointed and the location proved fantastic. We were able to watch my 4-year old daughter on her first day of ski school from the balcony of the condo!


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Popular Articles About Tiger Woods
Tiger Woods joins Twitter
November 18, 2010
NEW YORK: World former No. 1 golfer Tiger Woods launched his first Twitter page yesterday. "What's up everyone. Finally decided to try out twitter!" the New York Post quoted him as tweeting for the first time. In a second tweet, Woods said, "Yep, it's me. I think I like this twitter thing. You guys are awesome. Thanks for all the love. " Woods' public image has taken a beating since last November, when a car accident outside his Florida home triggered reports of...
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November 18, 2014
NEW DELHI: The Hero World Challenge -- the premier PGA TOUR event hosted by the Tiger Woods Foundation -- will tee-off at the Isleworth Golf & Country Club in Orlando, Florida from December 4 to 7 this year. The world's top 18 golfers, including 14-time major champion Woods, will participate in the tournament with a total prize purse of USD 3.5 million. Other marquee players who have confirmed participation in the tournament include Billy Horschel, Bubba Watson,...
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Samuel Agastya , TNN
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As we move toward celebrating World Tourism Day on September 27 this year, the mission statement holds special attention to Community Development. WTD 2014 highlights how tourism can be conducive to advancing sustainable development from the grassroots level. Community based tourism involves the local population in the decision making process according to local priorities. The opportunity to become part of the tourism value chain actively involves host...
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December 14, 2009
LONDON: Scandal-hit Tiger Woods' wife has been spotted without her wedding ring, strengthening rumors that the golfer's marriage has come to an end. Elin Nordegren reportedly had no gold band and diamond engagement ring on her finer, when she stopped for petrol, while taking a car trip from the couple's house in Windermere with her two kids. However, much couldn't be said about her mood, as she donned sunglasses. Meanwhile, reports have come that the...
Tiger Woods, wife may soon leave US
December 10, 2009
WASHINGTON: Scandal hit Tiger Woods and his wife Elin Nordegren are reportedly planning to leave their family home in Florida. The couple has been avoiding the public eye amid reports of the ace golfer's alleged extra-marital affairs. "Elin and Tiger are planning to temporarily move closer to Sweden, possibly to a private island, to get away from it all," Fox News quoted an insider as telling Pop Tarts. As many as 11 women have been linked...
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February 26, 2003
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May 9, 2010
FLORIDA: Tiger Woods withdrew from the Players championship during the final round on Sunday citing a neck injury . Woods, whose five-year-reign as world number one could end this week if Phil Mickelson wins the tournament, lasted less than seven holes before quitting at the Sawgrass TPC. "I've been playing with a bad neck for a while," said Woods, who was competing in just his third tournament of the year...
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October 2, 2009
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September 17, 2014
New York Times
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September 16, 2014
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August 18, 2014
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Celebs to Jessica Simpson: Where is the Baby?!by Free Britney at . Comments
Jessica Simpson has been pregnant for so long, and is so enormous, fellow stars are on pins and needles wondering where that giant baby girl is.
Maybe it's the non-stop Jessica Simpson quotes concerning her pregnancy that have slowed. Maybe it's the rumor that she already gave birth (false).
Whatever the reason, some inquiring minds really want to know on Twitter.
"Has Jessica Simpson had that baby yet?! I'm anxious," Katy Perry wrote.
Chelsea Handler was thinking the same thing. "How has jessica simpson still not given birth to this baby? I'm getting frightened," she wrote.
So are we. Simpson, who is still pregnant, announced her pregnancy on Halloween, six full months ago, well after tabloids got wind of it.
It's got to be due any minute now. Whenever little Maxi arrives, you can expect the fiancee of Eric Johnson to Tweet non-stop updates.
Seriously. This is a 31-year-old woman who has mused about her "swamp ass" and "the big O" of pregnant sex. There's no such thing as TMI.
[Photo: WENN.com]
It does not matter when her baby comes. That is Jessica's business.
When I was pregnant I went from a size 9 to a size 16, and everyone thought I was having triplets. Leave her alone, that baby will come when she's ready. And if she did have her, maybe she just want time alone with her daughter.
i love how people always thinks when a celeb is preg that something is up. Jessica has obviously gained alot of weight during her pregnancy, so she could have easily been 3 months looking like 5 or 6. When I was preg I was 3 months but I had gained so much that everyone thought I was 5. It all depends on the womans body. she also probably just doesn't want ppl to know the due date, maybe to actually get to keep something private in their lives.
Beyonce's pregnancy was weird to but ya'll still kiss her black ass!
Oh-I thought she was on her second one!!!!
There's something weird about this pregnancy. There were rumors because she was showing well before she formally announced this pregnancy at Halloween 2011 - six months ago which meant she was at least 3-4 months or more pregnant then. What's she carrying? A baby elephant? And why has she never announced her due date? In these modern days, doctors can darn near figure it to the day. Still...praying all is well.
I Kent wait for de baby
Its sweet of stars to care for each other


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Oscar Nominees: Off Duty
On Sunday night we'll be seeing these nominated actresses in all their highly styled glory. But what do they look like when they're far from the red carpet?
By Abby Gardner
Viola Davis
Viola seems to be a master at avoiding the paparazzi, but we did love the cape-like coat she wore out and about in NYC recently.


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With one twist this cool travel messenger bag doubles as a comfy saddle for your Trunki! The Saddlebag has enough room for their crayons, comics, treasures and more! Features include zip compartments, an adjustable body strap and a horn to move oncoming traffic out of the way! This one goes great with Terrance the blue Trunki. What a fun accessory for your travels!
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