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Chilean Miners Rescued, Celebs Tweet Reactionsby Hilton Hater at . Comments
As we type this, rescue efforts are underway in Chile for the dozens of minders that have been trapped more than 2,000 feet underground for over two and a half months.
It's an incredible, moving story, one not lost on a handful of celebrities, all of whom Tweeted their celebratory thoughts and prayers today...
Kim Kardashian: Wow seriously in tears watching this Chilean miners getting released on CNN! What a tough struggle they made it through!!!
Justin Bieber: Kust found out the miners of chile are being rescued!!! happy for the families being brought back together. miracles do happen.
Ryan Seacrest: If ur just waking up, 12 miners have been rescued in Chile, 21 to go. AMAZING work from all involved!Missy Elliott: The Chileans Miners will be a Testimony of how Real God is! Such a Blessing to see them healthy and n Great Spirits!
Derek Hough: Bless those miners…Pray pray pray…!!!!
Joel McHale: In Japan this whole mine rescue thing is known as a "Game Show".
Carrie Ann Inaba: SO HAPPY about the rescue efforts going on for the Chilean miners. God bless them all and those who are helping them get home! AMEN!!!
We welcome similar reactions and comments from THG readers on this amazing story.
Thanks for writing about this. Something else that's related to the issue is this video I saw on YouTube from the Top Trending Topics channel (not sure you knew but Chilean Miner is a trending topic today). Check it out: http://www.youtube.com/watch?v...
Woo hoo, the Chilean Miners are free at last!!!
Thanks THG, for including this update on the miners as part of today's headline news.


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Recall: Naproxen Bottles Mistakenly Filled with Ibuprofen
Updated: 10/22/2014 - A popular pain reliever is being recalled across the country.
Updated: 10/22/2014 - A popular pain reliever is being recalled across the country.
Updated: 10/22/2014 - There could be changes in open enrollment for your company's 2015 health care plans.
Updated: 10/22/2014 - An airbag recall reported earlier this week has been expanded.
Updated: 10/22/2014 - New details in the investigation into the Michael Brown shooting in Ferguson, Missouri.
Updated: 10/22/2014 - OTTAWA, Ontario (AP) -- Police in Ottawa say shots also were fired near a shopping mall close to Parliament.
Posted: 10/20/2014 - Millions of drivers could be affected by an airbag recall.
Posted: 10/20/2014 - Facebook may unfriend the U.S. Drug Enforcement Administration.
Posted: 10/20/2014 - 11 Parishes Wanted To Revive Lawsuits Over Wildlife Damage.
Posted: 10/20/2014 - A new survey suggests nearly half of shoppers will avoid retailers affected by last year's data breaches this holiday season.
Posted: 10/20/2014 - A new controversial Halloween costume this year features the very real fear of Ebola.
Posted: 10/17/2014 - Just miles from where the fatal shooting of Trayvon Martin launched a national debate over stand your ground laws, a federal commission is holding a hearing on whether there are racial disparities in the application of the law.
Posted: 10/16/2014 - Chrysler is recalling more than 900,000 vehicles.
Updated: 10/14/2014 - Now that the Ebola virus has been transmitted in the United States, hospital staff are taking steps to make sure they are fully prepared in just in case.
Posted: 10/13/2014 - Acura is recalling 43,000 cars to replace front seat belts.
Posted: 10/13/2014 - Believe it or not, there are just 10 weekends left to shop for the holidays.
Updated: 10/11/2014 - First Ebola Patient Diagnosed In U.S. Dies At Dallas Hospital.
Posted: 10/06/2014 - General Motors has recalled more than 57,000 cars in the U.S.
Posted: 10/03/2014 - Toys R Us is recalling about 19,000 Koala baby sandals for girls.
Posted: 10/03/2014 - The latest unemployment report shows the country's jobless rate is at a six-year low.
Updated: 10/02/2014 - Sgt. 1st Class Andrew Tarrant Weathers was assigned to 2nd Battalion, 7th SFG (A) when he died as a result of a gunshot wound he sustained while conducting combat operations in Afghanistan, Sept. 30, 2014.
Updated: 10/01/2014 - WASHINGTON (AP) -- Secret Service Director Julia Pierson has resigned amid security lapses at the White House.
Posted: 10/01/2014 - The type of car you drive could determine your likelihood of getting a ticket.
Updated: 10/01/2014 - Two gamers are facing prison time after hacking into software used to train Apache helicopter pilots.
Updated: 09/30/2014 - DALLAS (AP) -- Federal health officials have confirmed that a patient being treated at a Dallas hospital has tested positive for Ebola.
Posted: 09/26/2014 - Suspect Shot By Off-Duty Police Officer, Currently In Hospital.

subset: commoncrawl


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Last year, Tammy Barker and some local friends saw a need for a closer, more accessible place for some Brownstown residents and friends to do their Christmas and gift shopping.
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Wiki Headlines
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A character has an old robot and deliberately keeps it despite new models being around. It can be done for practical reasons or just to save money. If it's not, it's always a trait of good characters or, when villains do it, a Pet the Dog kind of trait. This is often An Aesop (and not even a very hidden one) where the old robot will be shown to have a much more developed (and human-like) personality, while the new models will be more able and better looking but unfeeling. However, it may just be sentimentality — the character has a relationship with the old robot that a Replacement Goldfish wouldn't fulfil. Alternatively, it could be used to establish a character's Perpetual Poverty, alongside their battered spaceship and antique internal-combustion car. After all, whatever the technology level, you can assume a state-of-the-art robotic assistant would be an expensive investment, so an older model might be all their budget allows. On a more cynical level, this can be down to Special Effects budget concerns. Animating your Robot Buddy takes a lot of effort, but it's worth it to flesh out (pardon the expression) a main character - but why put the same work into background characters when Ridiculously Human Robots require just a bit of makeup?
Examples:Anime and Manga


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- Age: 44
- Height: 6 ft 3 in
- Weight: 239 lbs.
Major Titles Held:WWE European Championship 1x
WWE Hardcore Championship 1x
Recent Shane McMahon News:
Journey of a Front Man recently interviewed AP Music Award founder Josh Bernstein, who discussed CM Punk getting involved with the APREAD MORE
– The Batista documentary, The Animal Unleashed, premieres on Thursday (No. 20) on the WWE Network. – WWE released a Top 10READ MORE
Partial Source: Chris Hewitson & Prowrestling.net – Friday's episode of WWE SmackDown saw some welcome relief in terms of viewership. The showREAD MORE
In an interview with Medio Tiempo, Myzteziz (the original Sin Cara) agreed with Alberto Del Rio's claims that there is racism fromREAD MORE
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Owner SSW Cutting Point Hooks are an excellent choice when using bait for a wide variety of fish species. The SSW Cutting Point Hooks are ideal when baiting up with roe for salmon and steelhead in the streams or trolling herring cut baits for salmon in saltwater. These hooks also work great when bait fishing for walleye, bass, tarpon and other inshore fish species. The Owner SSW Cutting Point Hooks offer top notch penetration, resistance actually decreases as the cutting point penetrates.
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Very good hooks, some of the best.
the best around very good
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Real Bout High School (Alternate title: Samurai Girl: Real Bout High School) is a martial arts manga written by Reiji Saiga and illustrated by Sora Inoue, serialized in Dragon Magazine from 1999 to 2003, and adapted into a 13-episode anime series in 2001.It centers around a high school where martial arts are part of the standard curriculum; one of its students, Samurai Girl Ryoko Mitsurugi, is the top fighter and most popular girl in school... until a challenger arrives in the form of the uncouth Shizuma Kusanagi, a transfer student from Kansai. While he lacks Ryoko's grace, he soon proves to be a powerful fighter, and may surpass Ryoko as the best fighter at Daimon High. Principal Takao Todo encourages rivalry between the competitors, setting up a dangerous "K-Fighting" tournament where even the teachers can join in and settle once-and-for-all just who is the top dog on campus.
This Manga contains examples of:


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Save the Bay: Elected officials oppose Cargill plan
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November 24, 2014
TISHOMINGO, Okla. (AP) - A species of turtle that had nearly disappeared from the state is back swimming in the waters of southeastern Oklahoma.
The U.S. Fish and Wildlife Service recently released 277 alligator snapping turtles into the Washita River drainage system, primarily in waters around the Tishomingo National Wildlife Refuge.
The Arkansas Game and Fish Commission confiscated the adult alligator snapping turtles from a commercial breeder and relocated them to southern Oklahoma, where they once flourished.
Alligator snapping turtles are different from the more common snapping turtle and can grow quite large. One found in Missouri weighed 316 pounds.
But Oklahoma State University researcher Day Ligon says it will be rare for people to come in contact with the turtles. Ligon says they'll generally stay in murky backwater sloughs and feed on rough fish, plants and dead animal carcasses.
Some of the released turtles have sonic transmitters attached to their shells and will be tracked by Oklahoma State University graduate students over the next several years.
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There are several types of online ads, each with their own characteristics, Kathryn Hawkins writes. For example, while few people might click on display ads, they can be useful for building brand awareness, she writes. Facebook ads, meanwhile, can be used to deliver targeted messaging, she notes.
View Full Article in:What Kind of Online Ad Should Your Small Business Run? - Intuit Small Business Blog
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Added Sep 8, 2007
Minneapolis, Min...
A little Prototype I tried, I wore it to the office only to get me sister to tell me later she thinks it a little to short. Is it to short? I need feedback since I have been to self concious to wear it since.
Perwinkle Blend w/ Linen Like Texture
Dec 17, 2010, 10.22 PMby charlotteauzou
I love the style of your dress.
Dec 12, 2008, 03.27 PMby pricklyplant
Probably too short for the work place.
But good any where else.
Jul 28, 2008, 02.31 PMby reneebeth
This is really cool! I love the sleeves and the top. the length is a bit like a tunic, but probably just looks that way because of the proportion of the sleeves. It's great!
Sep 8, 2007, 03.59 PMby lauriana
I'm afraid I have to agree. It looks really nice, but I'd opt for wearing it over leggings or skinny jeans, especially to the office. Don't let any of this discourage you though, it's a really nice creation.
Sep 7, 2007, 10.47 PMby emilykate
I really like it! It looks really comfy but very stylish. I'd love to make one, would you post a how-to or pattern? As to the shortness question, maaaaybe too short for an office, depending on the type of office! But here's the thing, if you wear opaque footless leggings underneath, and some little ballet flats on your feet, I think it's a nice little office outfit.
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Originally written on Fan View Point | Last updated 11/16/14
Boston Bruins General Manager Peter Chiarelli issued the following update today, February 1, on forward Shawn Thornton: Thornton will miss the next 7-10 days due to a concussion sustained during the first period of the Bruins/Sabres game on Thursday, January 31. Thornton has skated in seven games this season and has registered one goal and 25 penalty minutes. For his career, the 35-year-old has appeared in 457 games with 31 goals, 43 assists and 797 penalty minutes. The two-time Stanley Cup champion joined the Bruins as a free agent on July 1, 2007 and recently signed to a two-year contract extension through the 2013-14 season on March 17, 2012.The Bruins return to action on Saturday, February 2 when they visit the Maple Leafs in Toronto.
Original Story: http://www.fanviewpoint.com/2013/02/s...
PLAYERS: Shawn Thornton
TEAMS: Boston Bruins, Toronto Maple Leafs
TEAMS: Boston Bruins, Toronto Maple Leafs
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Suit up for a robotic Halloween when you wear the Android Morphsuit. This white, black and grey skin suit features anatomical print design along with a double zipper with reinforced stitching. This awesome costume is also breathable and see-through.
Wolf Belly Babies Toddler Costume
Win the hearts of gullible grandmas and smiling girls in red capes in the Wolf Belly Babies Toddler Costume. The charm of this dark grey wolf bodysuit with swirl detail and furry belly, ears and tail will have everyone wandering right over to this wolf.
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Latest Johnnie Walker Stories
NEW YORK, June 29 /PRNewswire-FirstCall/ -- In a landmark collaboration bringing together two idols of American pop culture, supermodel Marisa Miller is teaming-up with party icon Captain Morgan to serve as the Captain's "Official First Mate" for the world's leading premium spiced rum brand.
NEW YORK, June 28 /PRNewswire-FirstCall/ -- Diageo, the world's leading premium drink business with a collection of brands across spirits, wine and beer, today announced a sponsorship deal with the National Football League's (NFL) New York Giants and the New Meadowlands Stadium in East Rutherford, New Jersey.
NEW YORK, March 29 /PRNewswire-FirstCall/ -- With the close of the Winter Games, competitors across the country are now gearing up for a new kind of Games.
NEW YORK, Feb.
MIAMI, Jan. 15 /PRNewswire-FirstCall/ -- Diageo, the world's leading spirits, beer and wine company, is delivering more than 45,000 pounds of food and emergency supplies to earthquake victims in Haiti today. Diageo's specially commissioned 727 aircraft departs Miami this morning.
MIAMI, Jan.
NEW YORK, Dec. 8 /PRNewswire-FirstCall/ -- Providing solutions for today's adult shoppers just got much easier.
NORWALK, Conn., Oct.
WALTHAM, Mass., Oct. 8 /PRNewswire-USNewswire/ --The Responsible Retailing Forum (RRF), a leading organization in preventing underage sales of age-restricted products, announced today that it has been awarded a Small Business Innovation Research grant from the National Institute of Drug Abuse.
NEW YORK, Sept.
- Having a loud voice; vociferous; clamorous.
- Of grand or imposing sound.


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Facing gridlock, Italy turns to Norris proposal
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Guest opinion: Ethanol policy and the economy
UNL hosts climate agriculture workshop Nov. 19 in Holdrege
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A juvenile girl said a Sutherland man abused her on Sunday, and the man was jailed Thursday.
At 4 p.m. on Oct. 6, Lincoln County Sheriffs Deputies were called to Sutherland to check on an uncontrollable girl. When officers talked with the girl, they noticed injuries on her neck. The girl told them that her stepfather Kenneth McConnell lifted her up by her jacket, making it so she could not breathe.
The girl said McConnell then dropped her and she hit the back of her head.
McConnell, 46, told deputies that the girl was not doing as she was told and was being disrespectful to him and others.
McConnell did not deny that he lifted the girl up to control her, according to the Lincoln County Sheriffs Office.
McConnell is charged with felony child abuse. He paid 10 percent of a $10,000 bond and was released. He is scheduled to be arraigned on Nov. 15.
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Jackie Hurst
Jackie W. (Jack) Hurst age 79 of McDonough, GA passed away November 25, 2014.
Cathy Bradford
Cathy Padgett Hart Bradford, of McDonough, passed away on November 21, 2014.
Mr.. Charles Warren Hassler
Mr. Charles Warren Hassler Chuck, age 69, of McDonough, GA passed away November 22, 2014.
Mrs.. Geraldine McCormick
Mrs. Geraldine McCormick, age 75, of Stockbridge, GA, passed away Sunday, November 23, 2014.
Mrs.. Rosanne Donnelly
Mrs. Rosanne Z. Donnelly, age 90 of McDonough, Georgia passed away November 24, 2014.
Evelyn Hughes
Evelyn T. Hughes of Stockbridge passed away on November 18, 2014 surrounded by family.
Ollie Exum
Ollie Moss Exum, age 83, of Hampton, GA died Sunday, November 23, 2014.
Thomas Hester
Thomas A. (Tommy) Hester age 67 of Ellenwood passed away Thursday November 20, 2014 at Vitas Hospice.
Captain. Spencer Herbert Grant
On November 19, 2014, Captain Spencer Herbert Grant of Stockbridge GA made his final flight to glory on the wings of a snow white dove.
Rita Foster
Rita Noreen (nee Bennett) Foster, of Stockbridge, GA, died on 19 November 2014 at Vitas Hospice.
Mrs. Nancy Carol Ellenburg
Mrs. Nancy Carol Ellenburg, age 75, of Jonesboro, GA, passed away Tuesday, November 18, 2014.
Mr. Harvey E. Amy
Mr. Harvey E. Amy, age 83, of Jonesboro, GA, passed away Thursday, November 20, 2014.
Randy Raiford
Randy Raiford age 63 of Locust Grove passed away November 19, 2014.
Captain. Spencer Herbert Grant
On November 19, 2014, Captain Spencer Herbert Grant of Stockbridge GA made his final flight to glory on the wings of a snow white dove.
Mr.. Mark David Olson
Mr. Mark David Olson, age 51 of Jackson, Georgia passed away November 18, 2014.
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JMicron RAID ConfigurationThe JMicron JMB363 chipset, commonly called the JMicron RAID Configuration is a connector for a Serial ATA signal cable that supports a Serial ATA hard drive. The JMicron controller mode can be accessed in the BIOS and can be toggled between IDE (default) and RAID. The JMicron JMB363 Serial ATA Raid connector can be used to configure the following functions to serve as an alternative to creating RAID:
- RAID 0 (Data Striping)
- RAID 1 (Data Mirroring)
- JBOD (Spanning)
See also "Motherboards: What You Should Know" in the Quick Reference section of Webopedia.
To make the IoT both work and pay off, IT is juggling upgrading and building app-centric networks, mapping out new data center architectures and... Read More »What You Don't Read Can Hurt You
Does this sound familiar? An online service promises to help your small business cut costs, increase productivity, make your coffee and walk your... Read More »Who's Moving Ahead in Cloud Computing?
The future remains, well, cloudy. But either way: Amazon, look out. Microsoft is gaining fast. Read More »
The trend for the past two years has been for shoppers to spend more online during the holiday season. How do you typically shop for holiday... Read More »How to Create a Desktop Shortcut to a Website
This Webopedia guide will show you how to create a desktop shortcut to a website using Firefox, Chrome or Internet Explorer (IE). Read More »Flash Data Storage Vendor Trends
Although it is almost impossible to keep up with the pace of ongoing product releases, here are three recent highlights in the flash data storage... Read More »
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Get ideas and inspiration, find easy to use patterns
and tutorials for your next sewing project.
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MVC Widget Error
7 Tips to Prepare for Your Appointment
The key to a successful appointment is communication. To get the most out of your visit, prepare ahead of time so you can lead the conversation with your doctor. These 7 tips will get you ready
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If you are a new patient, please check with Tomo Tom before scheduling an appointment.
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Hotel Kyriad Chambery Centre Curial
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A Little More About Where I Live & School
... I will have throughout a week once; they have all asked me very similar questions about where I come from, what I like to do and of course with the younger students, What is your favourite...?
I will be adding some photos of my appartment later this week and probably adding some other posts with things that I have been doing with the other assistants.
Funny, How Fast A Week Can Pass
... a tour of the town as well as the
college. Through her emails, she has sounded quite motherly, as she
has offered me her home before I had even arrived in France, if I
needed anything I could just call her, if I didn't like my
apartment, I could stay with her until I found something.
You see? I am very well blessed and
those are just a few of the stories about how hospitable people have
been to me.
Chillon Castle & Into France
... a coffee and pan-o-chocolate. We have had buffet breakfasts for over three weeks now and I'm not going to miss having this one.
We walked a short distance to a French restaurant (L'ecuelle) that was recommended to us by the front desk of our hotel. I ordered the chicken breast, and Eldon ordered the fried perch. The food was AMAZING. One of the best meals we have had since we left home. My breast was cooked to perfection on a bed of ...
Practically French.
This morning was relatively quiet as Amy and Jono had a sleep in. Although we had plans to check out the local markets early, we didn't leave the house until 10.30am. I guess I had to let them off though considering it was Sunday and day after the game! Amy and I headed down to the markets while Jono enjoyed some more R&R. After just a short ten minute walk and we were there. There was fresh flowers and fruit and meats and seafood and tapanades and ...
... s terrace, freshened up a bit, had a nice dinner and finished up with an evening stroll around town.
Wednesday 9/17 - Checked out of the hotel early and caught the TGV back to Paris with a connecting a connecting train to our next stop - Amboise.
If you would like to see all of our pictures from Annecy, please click here


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Halloween Costumes
Best Trendy Halloween Costumes Of 2014
Need some inspiration for this season's Halloween costume? Check out these trendy Halloween costumes inspired by pop culture.
How To Make DIY Halloween Masks
Use everyday materials to design your own Halloween masks in just a few hours.
Best Creative Couples Costumes For Adults
Want the world to know you two are tight as Batman and Robin? Check out these dynamic duo, Halloween twosomes.
Classic Halloween Villain Costumes For Kids
Let your kids plot world domination this Halloween with these classic villain costumes.
How To Get Your Halloween Costume On A Budget In Charlotte
Finding a great Halloween costume without breaking the bank is often a challenge. But here in Charlotte, there are some amazing options, you just have to think outside the box.
Best Halloween Costumes of 2013
Halloween is right around the corner! Have you thought of your costume yet? We list the top costumes of 2013 that are sure to be hit.
Best Halloween Costumes Of 2012
Step away from the prepackaged Halloween costumes in a box. Get a bit creative and find some inspiration from today's pop culture. Here are a few great costume ideas to get your Halloween creativity going.
The Haunted Maddhouse And Miguel
Spend Halloween night with the Haunted Maddhouse! Join Power 98's Morning Maddhouse for Miguel in concert on Monday, October 31st at The Fillmore at the NC Music Factory. You can wear a Halloween costume if you want!


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"Domestic violence was a way of life for them. I was met with statements like ' Woh mard hi kya jo aurat ko na maare ' (what kind of a man doesn't beat women). When I set up Shaheen in this locality of Sultan Shahi there were not too many people open to change. It is only over time that women have begun to realise that they have a choice too," says Jameela, who is also an executive member at Asmita Resource Centre for Women. On several occasions Jameela and her team have busted fake marriage attempts by Arab men with young city girls.
It took tremendous tact and patience on her part to get her point across. "When I first began coming to this place, I approached the girls saying I could help them with English. Being summer vacations more than 50 girls came forward to learn the language. Gradually a month later I broached the topic of sexuality. Instantly 50 girls stopped coming and I was left with just five who were willing to work with me to create awareness. That is how Shaheen began," she explains.
Needless to say, there was a lot of resistance. "I remember one particular incident when I was surrounded by more than 25 men, who did not agree with my work. This happened after the 2003 riots in Old City. I decided to hold a workshop for the Muslim, Dalit and BC boys on communal harmony. When our staffers and other girls sat alongside them for the workshop, the boys were livid. They were worried the girls would elope with Dalit boys," she says.
Now, she says, challenges have become a way of life for her and the staff at Shaheen. But the change did come about. Slowly women began approaching Jameela for help and numerous cases of domestic violence and incest came to light. "There have been cases of women seeking a divorce after tolerating violence for 25 years. They are slowly beginning to realise that abuse is not a way of life. Most heart-rending are cases of incest. We once had a seven-year-old girl tell us that her 12-year-old sister was covered in cigarette burns by their step-father. When we met the girl we learnt that the man had been sexually abusing her.
In another case a mentally unstable girl had been violated for several years by a maulvi under the pretext of treating her. We intervene and try to rehabilitate these girls. But resistance still persists in some people," says Jameela, recalling an incident where a young woman was tied to the cot and set ablaze by her husband. But nobody from the girl's family wanted to press charges. The girl herself told the police that it was just an accident.
For Jameela these are not mere cases. "I live these cases myself. Victims don't need our sympathy, they need empathy. And that is what I do," she says. Quiz her on how her family reacts to her work and she says, "I come from a very cosmopolitan family. My father was a painter and I a poet. My husband is an atheist and does not believe in these practices. We are like friends living under one roof. My sons also understand and appreciate what I do. As such I do not discuss my work with my family. My siblings know about what I do through newspaper articles."
Her true dream though was to become an artist. "However, my father was sceptical about me going to art school since we would have to paint nude models. However, writing was encouraged in Muslim households, so I took to poetry," says, adding that she spent her childhood watching M.F. Hussain paint on their living room floor. "He was my father's close friend. He would roll out a canvas on our living room floor, sit on it and create a masterpiece in no time. Sometimes he would just use his hands to spread the colour. I would watch him and paint some pieces myself and pass it off as my brother's work," she laughs.
Through all of this, Jameela's poetry is her constant solace. "I begin my mornings by writing a couplet. I write about the incidents I come across. It helps to channel my feelings through words," she says, sharing a couplet she recently penned, which she says aptly describes her life.
Iss zindagi ki raah mein
Aese nikal padi
Meri talab sab ko hai,
Mera hisab kucch nahi
When I broached the topic of sexuality, instantly 50 girls stopped coming and I was left with just five who were willing to work with me to create awareness. That is how Shaheen began.


text:
See accompanying Article: http://dx.doi.org/10.1002/eji.201242678
TB or not TB: The role of immunodiagnosis
Article first published online: 29 OCT 2012
DOI: 10.1002/eji.201242950
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 42, Issue 11, pages 2840–2843, November 2012
Additional Information
How to Cite
Lange, C. and Sester, M. (2012), TB or not TB: The role of immunodiagnosis. Eur. J. Immunol., 42: 2840–2843. doi: 10.1002/eji.201242950
Publication History
- Issue published online: 29 OCT 2012
- Article first published online: 29 OCT 2012
- Manuscript Accepted: 24 SEP 2012
- Manuscript Received: 28 AUG 2012
- Manuscript Revised: 28 AUG 2012
- Abstract
- Article
- References
- Cited By
- Infectious diseases;
- Interferons;
- T cells
The evaluation of delayed-type hypersensitivity immune responses by the tuberculin skin test and, more recently, by ex vivo IFN-γ release assays (IGRAs) form the basis for the risk assessment for the development of tuberculosis (TB) in close contacts of infective index patients and in immunocompromised hosts. In contrast, immunodiagnosis has little value for the diagnosis of active TB so far. A report in this issue of the European Journal of Immunology [Eur J Immunol 2012. 42: 2844–2850] provides new insight into the phenotypic characteristics and selective recruitment of Ag-specific T cells to the site of the infection, as analyzed by flow cytometry, which may provide new opportunities for the immune-based diagnosis of TB in the future.
TB is a leading cause of morbidity in developing countries and ranks as the eighth most frequent cause of all deaths worldwide. The World Health Organization (WHO) recently estimated that 8.8 million persons developed TB in the year 2010 and 1.4 million patients died from this disease that year [1]. TB can develop following inhalation of Mycobacterium tuberculosis from the exhalate of patients with pulmonary TB, the predominant clinical manifestation of this disease. Mechanisms of innate immune defense involving the action of antimicrobial peptides and the activity of polymorphonuclear neutrophilic granulocytes may prevent persistent infection of the host [2, 3]. Once M. tuberculosis enters alveolar macrophages — the host cells for chronic pulmonary infection — the bacterium may evade killing, survive and replicate within these cells [4]. However, even in cases of chronic infection, active TB is generally prevented by the recruitment of Ag-specific T cells to the site of infection. These T cells surround infected macrophages and form a granuloma to prevent further spread of the bacteria in the majority of cases [5].
Analyses of Ag-specific immune responses have played an important role in the diagnosis of TB for more than a century. In 1907, an "allergy test for tuberculosis" was proposed by the pediatrician Clemens von Pirquet from Vienna, who elicited delayed hypersensitivity skin reactions following the application of a sterile supernatant of liquid M. tuberculosis cultures (tuberculin) in skin lacerations of both children with TB and healthy controls [6]. These observations provided the first evidence that immune responses by skin testing were unable to distinguish children with active TB from healthy children. Thus, healthy contacts with positive tuberculin skin test reactions were thought to be latently infected with M. tuberculosis. Based on information derived from the tuberculin skin test responses and the determination of the percentage of healthy individuals who subsequently developed TB, it was estimated that approximately 5–10% of persons with latent M. tuberculosis infection develop active TB during their lifetime [7], with the risk being highest in the first 2 years following primary infection (approximately 2% [8]). These observations formed the rationale for using tuberculin skin testing to estimate the risk for recent TB contacts and immunocompromised individuals of developing TB in the future. The tuberculin skin test was modified by Felix Mendel and Charles Mantoux for intradermal application [9, 10] and was used for almost one century in this format to diagnose latent infection with M. tuberculosis.
Apart from the inability to distinguish active from latent infection, another disadvantage of the skin test is its inability to distinguish individuals that are "truly" latently infected with M. tuberculosis from individuals who have been vaccinated with M. bovis BCG, the most commonly used vaccine worldwide [11]; however, specificity for infection with M. tuberculosis was able to be improved when bacterial virulence factors, such as early-secretory-antigenic target 6 and culture-filtrate-protein 10, were identified as being M. tuberculosis specific Ags that are not produced by M. bovis BCG vaccine strains [12]. The use of these Ags was subsequently applied in tests that elicit IFN-γ responses from M. tuberculosis specific T cells in peripheral blood and two ex vivo IFN-γ release assays (IGRAs) are currently commercially available in ELISA (Quantiferon Gold in tube) or ELISPOT (T-SPOT.TB) formats.
While the detection of M. tuberculosis specific immune responses was improved by IGRAs, the positive predictive value to identify individuals at risk for the future development of TB remained considerably low [13]. In addition, the standard use of IGRAs on cells from the peripheral blood has not been able to overcome one of the major limitations of the tuberculin skin test, namely to distinguish patients with active TB from individuals with latent M. tuberculosis infection [14] (Table 1). In general, the percentage of M. tuberculosis specific circulating cells identified by IGRAs is higher in patients with active TB as compared with those identified in healthy individuals with a positive IGRA response. Nevertheless, the test results of both populations overlap substantially, which precludes the correct assignment of the actual infection status on an individual basis. Therefore, new immune-based approaches have been explored to increase the specificity for the diagnosis of active TB (Table 1).
|Tuberculin skin tests, commercial IGRAs
|Enumeration of M. tuberculosis specific T cells from blood and extrasanguinous fluids
|Cytokine profiling and/or phenotyping of M. tuberculosis specific T cells from whole blood
|Phenotyping of bulk CD4+ T cells from blood and extrasanguinous fluids
|Diagnosis of active tuberculosis
|Test format
|e.g. RT 23 SSIa T.SPOT.TB; QuantiFERON TB Gold in tube
|ELISPOT assay
|Flow cytometry
|Flow cytometry
|Material required
|Skin, blood
|Blood and extrasanguinous fluids
|Blood and extrasanguinous fluids
|Stimulation required
|Time required for the result
|48–72 h (TST) 24 h (IGRAs)
|20-h incubation and 3 h for the final results
|6- to 20-h incubation and 2 h for the final results
|1 h
|Diameter of dermal induration (mm) IFN-γ secretion/IFN-γ producing cells
|Accumulation of cytokine-producing cells in extrasanguinous samples versus blood
|Shift in cytokine profile/change in phenotype
|Accumulation of CD27−CD4+ T cells in extrasanguinous samples versus blood
The most promising of these approaches have made use of the selective recruitment of M. tuberculosis specific T cells from the peripheral blood to the site of infection [15], and of the differential phenotype and functionality of Ag-specific T cells in association with pathogen load. Indeed, when comparatively analyzing peripheral blood and extrasanguinous fluids from patients with active TB, an increased percentage of Ag-specific T cells was found at the site of the infection, which was not found in individuals with latent infection; this has convincingly been shown for bronchoalveolar lavage fluid in pulmonary TB [16], pleural fluid in tuberculous pleurisy [17, 18], cerebrospinal fluid in tuberculous meningitis [19, 20], and ascites in tuberculous peritonitis [21], with the concentration of Ag-specific T cells being five- to 17-fold higher at the site of the infection when compared with that in the peripheral blood [16, 17, 22]. In a recent meta-analysis by the Tuberculosis European Network Trials Group (TBNET; www.tb-net.org), the IGRA ELISPOT technique performed on cells from extrasanguinous fluids was the best immunodiagnostic method for identifying patients with active TB, giving a pooled diagnostic sensitivity of 88% and a pooled diagnostic specificity of 82% on cases that predominantly had an acid fast bacilli smear negative manifestation of the disease [14]. Therefore, commercial blood-based assays may be modified to give novel methods for the immunodiagnosis of acid fast bacilli smear negative pulmonary and extrapulmonary TB.
An alternative approach to identify patients with active disease has made use of the fact that the functionality [23, 24] and phenotype [25] of Ag-specific T cells may critically determine the immune control of pathogen replication (Table 1). In this respect, a shift in the cytokine profile from multifunctionality toward cells expressing single cytokines has been associated with active TB [23, 24]. In addition, cytokine-producing cells in patients with active disease typically exhibit a terminally differentiated phenotype that is characterized as predominantly CD27− [25], whereas the Ag-specific immune response in individuals with nonactive states generally consists of equal percentages of CD27+ and CD27− CD4+ T cells [26, 27]. Both phenotypic and functional analyses may be elegantly performed using multiparameter flow cytometry directly on whole blood, but Ag-specific stimulation and cytokine induction are required to assign key characteristics of functionally anergic cells to cells specific for mycobacterial Ags.
In this issue of the European Journal of Immunology, Nemeth et al. [28] have used flow cytometry to combine a compartmentalized analysis of T-cell subpopulations with a differential assessment of the phenotypic characteristics of the Ag-specific T cells that are typical for patients with active TB. The phenotype and function of T cells from the peripheral blood and from the site of the infection were analyzed in patients with extrapulmonary TB (mainly tuberculous pleurisy) and in patients with other lung diseases unrelated to TB. The most striking finding was the fact that in TB patients the percentage of CD27−CD4+ T cells at the site of infection was significantly lower compared with that in peripheral blood. Of note, this finding was irrespective of Ag-specificity and no such difference was found when similar analyses were performed in patients with diagnoses other than TB (Table 1). When the T-cell subtypes in both compartments were analyzed for specificity toward M. tuberculosis by concomitant assessment of IFN-γ, cytokine-producing cells in peripheral blood were found among both CD27− and CD27+ populations, whereas M. tuberculosis specific CD4+ T cells at the site of infection were predominantly restricted to the CD27− subset. Together the data indicate that M. tuberculosis specific T cells that accumulate at the site of infection are mainly confined to the CD27−CD4+ T-cell subpopulation. As an increase in the percentage of CD4+ T cells with this phenotype is already evident from bulk CD4+ T cells in the absence of specific stimulation, this offers the possibility to use the selective accumulation of CD27−CD4+ T cells in samples from the site of infection as surrogates for M. tuberculosis specific cells and thus as an indicator for active TB. This analysis may be performed from small sample volumes without the need for specific stimulation as highlighted in Table 1. However, given that even phenotypic bulk analyses were performed after an 18 h incubation period in the presence of brefeldin A, the diagnostic potential of a direct cell surface staining procedure still needs to be formally proven.
The study has some limitations in that only 13 of 178 suspects for active TB were actually included, of which seven served as controls with diagnoses other than TB. Thus, the total number of patients with active disease was very small and not representative for pulmonary TB or different forms of extrapulmonary TB. Moreover, control groups of individuals with BCG vaccination or clear evidence of latent infection with M. tuberculosis should have been recruited to prove whether a high percentage of CD27− T cells is specifically confined to patients with active TB. Likewise, patients with other types of inflammatory, granulomatous, and/or infectious diseases should have been evaluated as controls. If confirmed in larger studies with larger sample sizes, direct immunophenotyping of cells from the site of the infection (e.g. bronchoalveolar lavage, ascites, cerebrospinal fluid, pleural effusion, pericardial fluid) using flow cytometry may become an option to improve the difficult identification of TB cases as the diagnostic accuracy of nucleic acid amplification for M. tuberculosis DNA is still inadequate to rule out active disease in patients with acid fast bacilli negative smears [29] or in patients with extrapulmonary TB [30].
Conflict of interest
M.S. and C.L. have received kits free of charge by Cellestis and Oxford Immunotec to study the performance of IGRA responses in immunocompromised patients. M.S. has a patent application entitled "In vitro process for the quick determination of a patient's status relating to infection with Mycobacterium tuberculosis" (international patent number WO2011113953/A1).
- 1WHO, Global tuberculosis control report, Geneva, Switzerland, 2011.
- 2Tuberculosis: latency and reactivation. Infect. Immun. 2001. 69: 4195–4201.and ,
- 3Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB. Chest 2010. 137: 122–128., , , , , , et al.,
- 4Mycobacterium tuberculosis and the host response. J. Exp. Med. 2005. 201: 1693–1697., , , and ,
- 5New insights into the function of granulomas in human tuberculosis. J. Pathol. 2006. 208: 261–269.and ,
- 6Die Allergieprobe zur Diagnose der Tuberkulose im Kindesalter. Wien. Med. Wochenschr. 1907. 57: 1370–1374.,
- 7The prognosis of a positive tuberculin reaction in childhood and adolescence. Am. J. Epidemiol. 1974. 99: 131–138., and ,
- 8Predictive value of interferon-gamma release assays for incident active tuberculosis: a systematic review and meta-analysis. Lancet Infect. Dis. 2012. 12: 45–55., , , , , , et al.,
- 9Über intrakutane Tuberkulinanwendung zu diagnostischen Zwecken (Intrakutanreaktion). Beitr. Klin. Tuberk. 1909. 13: 139–144.,
- 10L'intradermo-reaction de la tuberculine et son interpretation clinique. Presse. Med. 1910. 2: 10–13.,
- 11LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. Eur. Respir. J. 2009. 33: 956–973., , , , , , et al.,
- 12T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings. Curr. Opin. Pulm. Med. 2009. 15: 188–200., , and ,
- 13Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. Eur. Respir. J. 2011. 37: 88–99., , , , , , et al.,
- 14Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur. Respir. J. 2011. 37: 100–111., , , , , , et al.,
- 15Suttons's law: local immunodiagnosis of tuberculosis. Infection 2008. 36: 510–514.and ,
- 16Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study. Am. J. Respir. Crit. Care Med. 2009. 180: 666–673., , , , , , et al.,
- 17Use of a T-cell interferon-gamma release assay for the diagnosis of tuberculous pleurisy. Eur. Respir. J. 2007. 30: 1173–1179., , , , , , et al.,
- 18Rapid diagnosis of tuberculous pleuritis by a T-cell interferon-gamma release assay. Scand J. Infect. Dis. 2009. 41: 232–236., , , , and ,
- 19Rapid diagnosis of Mycobacterium tuberculosis meningitis by enumeration of cerebrospinal fluid antigen-specific T-cells. Int. J. Tuberc. Lung Dis. 2008. 12: 651–657., , , , , , et al.,
- 20Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin. Infect. Dis. 2010. 50: 1349–1358., , , , , , et al.,
- 21Interferon-gamma release assay in the ascites: Early hint for diagnosis of abdominal tuberculosis. Infection 2010. 38: 69–72., , , , , , et al.,
- 22Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. Clin. Infect. Dis. 2005. 40: 184–187., , , , , , et al.,
- 23Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states. PLoS One 2011. 6: e17813., , , , , , et al.,
- 24Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat. Med. 2011. 17: 372–376., , , , , , et al.,
- 25Loss of receptor on tuberculin-reactive T-cells marks active pulmonary tuberculosis. PLoS ONE 2007. 2: e735., , , , , , et al.,
- 26Tuberculin skin testing underestimates a high prevalence of latent tuberculosis infection in hemodialysis patients. Kidney Int. 2004. 65: 1826–1834., , , , , , et al.,
- 27Distinct effector memory CD4+ T cell signatures in latent Mycobacterium tuberculosis infection, BCG vaccination and clinically resolved tuberculosis. PLoS One 2012. 7: e36046., , , , and ,
- 28Active tuberculosis is characterized by an antigen-specific and strictly localized expansion of effector T cells at the site of infection. Eur. J. Immunol. 2012. 42: 2844–2850., , , , and ,
- 29Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med. 2010. 363: 1005–1015., , , , , , et al.,
- 30Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system. J. Clin. Microbiol. 2011. 49: 1202–1205., , and ,
IFN-γ release assay


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Oosterdam Cruise Review by loricsea: We loved this Cruise!
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We loved this Cruise!
We just got back from a wonderful cruise on the Oosterdam. Where do I begin? Everything about this ship was truly an experience we won't shortly forget. This ship is beautiful! Easy to get around and within the first few hours it truly became our home. The crew were so attentive and friendly. Our ship's steward was impeccable. Our room was a little smaller than we had expected but larger than any other we had on other cruise ships. This a 5 star ship! Most of the crew was Indonesian and Filipino. Sweetest. hard working people you could ever meet
The show were so entertaining we even stayed to watch again missing dinner one nite. Our ship's Captain David was wonderful, so talented and kind. He works so hard. Julie Barr is the ship's comedian..so funny! Singers and dancers too were great. I could go on and on but it really was just wonderful.
We will probably sail again on Holland America. It is an excellent shipline. I highly recommend this cruise to others. Less
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|First Community Bank Community Calendar
|Written by Administrator
|Saturday, 31 August 2013 06:00
October 11 - The 22nd annual Alabama Cotton Festival will be held Saturday, October 11, from 8 a.m. until 2 p.m. in downtown Eclectic. The event will feature live music from The Springs, the Josh Brannon Band and more. There will also be a free Kid's Zone, a Sweet Treats Contest, a Classic/Antique Car Show, the Alabama Cotton Queen Pageant, the Alabama Rook Tournament and much more! Admission is free and everyone is invited. For more information, visit townofeclectic.com or call Heather Frazier at 334-521-3581.
October 14 - Elmore County Education Retirees Association will meet at Coaches Corner in Wetumpka at 11am. Flu shots.
October 21 - All HSEC members are invited to our Annual Meeting on Tuesday, 21 October, 6 pm, Trinity Episcopal Church, Hwy 231, Wetumpka. Join us to review our accomplishments & future plans and meet all who care about the future of our shelter! We will also be approving minor changes to our Society ByLaws and you can see those on the home page of our website at www.elmorehumane.org .
Ongoing Events:
Second and Fourth Tuesdays - The Millbrook City Council meets in the Municipal Courtroom The City Council meets the second or fourth Tuesday of each month in the Judicial Complex located at 3821 Grandview Road at 6:00 p.m. Work session normally begins at 5:30 p.m. Meeting updates will be posted here as they become available.
Second and Fourth Thursdays - The Millbrook Men's Club meets the second and fourth Thursday of each month at the Millbrook Memorial Center (behind Millbrook Library on Grandview Road). The club is open to interested men who live in the Millbrook area. The club raises money through a pair of annual barbecues to support local park improvements, city ammenities, youth scholarships, scouting troops and other improvements in Millbrook. The club meets for social time at 6:30pm with the business meeting at 7pm.
Thursdays - The Elmore County Extension Offices offers FREE Basic Parenting lessons each Thursday from 1p,-2:30pm. Program covers child development, protective factors, appropriate discipline, communication, and stress management. Please contact the Elmore County Extension Office at 334-567-6301 for more information
|Last Updated on Friday, 03 October 2014 14:38
It appears State Senator-elect Clyde Chambliss (pictured) may be facing his first post-election hurdle in the form of an ethics complaint.Read more...
Several Ford Model A clubs came together for a trip through Alabama and visited Millbrook to see Gene Jones' collection of antique tractors, arrowheads and spear points.
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Grace Connects Men and Women - Word Document [Download]
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Publisher's Description
How can an ancient biblical concept grace transform marriage in the information age?
Forget Mars and Venus. Author Rhonda Rhea finds that men are computers, always processing data but not always giving feedback, while women are cell phones, forever seeking to give someone an earful of information. With such different communication modes, it s not surprising that husbands and wives often fail to connect. The solution is not more gadgets, but supernatural assistance from the one who created men, women, and the marriage bond between them. The universal language linking human computers and cell phones is grace.
What is grace? Where does it come from? What does it add to a marriage? These are the questions we ll be asking and discussing in this study.
Table of Contents
SCRIPTURE: John 1:14 16; 2 Corinthians 12:7 10; Colossians 3:12 17; James 1:17; 4:1 10; 1 Peter 4:8 11
Identify the Current Issue
Discover the Eternal Principles
--Teaching point one: Grace comes from God.
--Teaching point two: You cannot give what you do not have.
--Teaching point three: Giving grace is a blessing in itself.
Apply Your Findings
Additional Resources
Men Are Computers, Women Are Cell Phones, by Rhonda Rhea (2003)
You have permission to make up to 1,000 copies for use in your local church.
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Easy Download And Installation of Whatsapp For Nokia X:-
Whatsapp for Nokia X is now achieved here. The Nokia Company launches the Nokia X Mobile without the Whatsapp as a pre installed software. We here to be to teach that Download and Install Whatsapp for Nokia X, XL & X+. This Nokia X will supports the android softwares like Whatsapp Messenger and Facebook Messenger and etc..
The Android will tie up with the Google products, so the default apps installed in the android mobiles were the Google Products only. But in Nokia Mobiles, They are Tie up with the Microsoft Company so the Default search apps is Bing Search & Outlook. The Nokia X is also the product of Nokia mobiles but it supports Android apps. It supports all apps from the Google Playstore. But Unfortunately The Whatsapp for Nokia X is not available in the play store.
|Whatsapp For Nokia X
Download Whatsapp From Nokia Platform:-
This is like as the ovi store but here provides the whatsapp software for the Nokia X, XL & X+ mobile versions. The Direct Link was provided below to install the whatsapp software for your Nokia X series mobile versions and by Search and download.
- In Nokia Store, Find an App Named "1MobileMarket".
- Install and Run it.
- Check That you install the official whatsapp version.
- Install It.
( Other wise )
- Direct Download Link Click Here.
Steps to Install Whatsapp on your Nokia X Mobile:-
- After You Download the app from the Nokia Store.
- Install the 1MobileMarket on your Nokia Phone.
- Its like a Mobile store and search the whatsapp for Nokia X in that search bar.
- Download the Official version of whatsapp on your phone and install it.
- If you have any error occurs during the installation, turn on the installation from unknown sources.
- Launch the App.
- It will use SMS to verify.
Watch the Tutorial That How to Download and Install Whatsapp For Nokia X version Click Here
|Whatsapp On Nokia
Tutorial Credits:- wpxbox.comIf there any problem occurs comment below.
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All Schools
(5) All Schools
(5) High Schools
(2) High Schools
(2) Elementary Schools
(4) Elementary Schools
(4) Preschools
(1) Preschools
(1) Public Schools
(9) Public Schools
(5) All Schools
(5) High Schools
(2) High Schools
(2) Elementary Schools
(4) Elementary Schools
(4) Preschools
(1) Preschools
(1) Public Schools
(9) Public Schools
There are 5 private schools in zipcode 94559, CA, serving 648 students.
Minority enrollment is 40% of the student body, which is less than the CA state average of 41%.
The student:teacher ratio of 10:1 is lower than the state private school average of 11:1.
94559, California Private Schools
- School Location Students Grades
NapaBlue Oak School
1436 Polk Street
Napa, CA, 94559
(707)261-4500188 students | Gr. K-8
NapaHopper Creek Montessori
2141 2nd Street
Napa, CA, 94559
(707)252-8775Montessori School35 students | Gr. PK-NS
NapaNapa Christian Campus Of Education
2201 Pine St
Napa, CA, 94559
(707)255-5233(Seventh-Day Adventist)136 students | Gr. KG-12
NapaSt John The Baptist Catholic School
983 Napa St
Napa, CA, 94559
(707)224-8388(Roman Catholic)218 students | Gr. KG-8
NapaThe Oxbow School
530 3rd St
Napa, CA, 94559
(707)255-6000Special Program Emphasis71 students | Gr. 11-12
Zipcode Statistics
|About This Zipcode (94559)
|Zipcode Statistics
|(CA) State Statistics
|Population (Approximate)
|27,184 people
|36,395,123 people
|Age 25+ w/College Degree
|Median Household Income
Recent Articles
Updated October 26, 2014
What do you do when you are dissatisfied with your local public schools? Homeschool your children? Send them to private school? Let's look at your options.
Your religion matters to you. You want your child to attend a school which will combine academics and religious education. Here is an overview of what is available together with some links to denominational web sites.
Add things up and you'll quickly find the answer- math is crucial both in academics and the real world. By following these strategies and following personal training programs, students can uncover their weaknesses and conquer math.


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Webinar: Los Cabos UnstoppableJoin us on 11/25 for the official destination update as the winter season approaches for Los Cabos.Register now
On Demand WebinarsExplore our library of over 50 On Demand webinars. There are items of interest for everyone.Learn Now>>
A drunk passenger aboard Holland America Line's Ryndam released the vessel's stern anchor as the cruise ship was returning to Tampa from Costa Maya, Mexico, on a weeklong western Caribbean itinerary last weekend.
Although deploying the anchor could have caused significant damage, the Ryndam was unharmed.
The FBI has charged Rick Ehlert, 44, of Thousand Oaks, Calif., with attempting to "damage, destroy, disable or wreck a vessel." That's a felony charge.
The ship was in motion with about 1,950 passengers and crew onboard at the time of the incident.
A subsequent review of the ship's surveillance video showed Ehlert entering a restricted work area, donning work gloves and releasing the anchor at 5:30 a.m. on Nov. 27 while still dressed in his formal attire from the previous evening. Ehlert was traveling with his girlfriend.
Once the ship docked in Tampa, he was met by agents of the FBI and the U.S. Coast Guard Investigative Service and admitted to being drunk, throwing a life buoy overboard and disabling the anchor.
He claimed to own a 50-foot boat that had a similar anchor system.
Holland America confirmed that the details in the FBI affidavit "accurately reflect what happened, to the best of our knowledge."
Wonder what Ehlert's bar tab was for that night?
— Gay Nagle Myers
"Contrary to some thoughts, travel agents do exist ... We are
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clients have better experiences. And as our personal motto is: Our
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A federal appeals court panel has rejected a defense that the cruise
industry has used for a quarter...
On the third day of CruiseWorld, Norwegian Cruise Line CEO Kevin Sheehan addressed the audience, followed by the President's Panel.
Jaf Travel offers a seven-night trip to Guatemala visiting Guatemala City, Antigua, Chichicastenango, Lake Atitlan and Tikal.
Flo Tours offers an 18-night trip to the South Pacific with two departures in 2015 stopping in Auckland, Waitomo, Rotorua and Queenstown, New Zealand; Sydney, Alice Springs, Ayers Rock, Cairns and Port...
Great Safaris features a land tour in Kenya this winter visiting Nairobi, Samburu, Lake Nakuru and the Masai Mara.
Pacific Delight Tours' China trip spends three nights in Beijing, four nights cruising the Yangtze River, two nights in Xian and three nights in Shanghai.
Flo Tours offers a 13-night trip spending four nights in Azerbaijan, five nights in Georgia and four nights in Armenia with departures in April and October.
With the "Paddington" movie set to debut Nov. 28 in the U.K. (Jan. 16 in the U.S.), the Draycott Hotel in London is offering a Paddington Bear Experience plan.
The Regent Porto Montenegro, located on the Bay of Kotor in Tivat, Montenegro, is celebrating its recent opening with an introductory rate on stays in specific room categories.
Il Salviatino, a restored villa hotel located about 15 minutes from downtown Florence, is offering a package focusing on Tuscan cuisine.
Crossroads Tours is cutting rates for two of its 2015 tours by $100 on bookings made by March 15. In addition, the operator will pay agents 15% commission on all packages from its 2015 lineup.
Los Cabos is more alive than ever. Only a short time after Hurricane...
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Riviera Nayarit. The words evoke a sense of an exotic gateway.
Sunday, January 25, 2015International Tour Management Institute Symposium
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57, Syracuse, NYAs the clock keeps ticking, I want to enjoy life as it is, accepting where I am right now but trying to focus on what God wants me to do. I realize what I want may not be what...
44, Evans Mills, NYIm a simple individual with a warm & kind heart.i love to be sorrounded to people with positive vibes rather than negativity.i am a God fearing person & i do believe to put Go...
22, Binghamton, NYHi! My name is Nha/Lina. I'm Vietnamese :) I have so many things to tell u guys.im waiting u:) to be honest I want to marry someone who is catholic too and as soon as I can(pr...
34, Poland, NYHow to describe myself.. Lets make this different and unique. Eden in a nutshell.. Here it goes ++My faith and relationship with God: God has perfect timing; never early, n...
25, Binghamton, NYSimple, shy, quite viet girl but sometimes i'm so annoying :) I'm a good listener. The first thing people usually notice about me is my Asian eyes ;) Things I could never ...
45, Binghamton, NYHi, My name is Hyejin and I am from South Korea. I go to State University of New York at Binghamton, starting from this fall semester. I am a graduate student taking master de...
50, Chittenango, NYHi my name is stacy, or should i say O herro, misa stacy ping pang! thats because im a short ugly asian. I often eat cats and small children - when they wander into my restaur...
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Search Results for Heroes
Edward Norton Sounds Off On Not Playing The Hulk In 'Avengers'
take on Dr. Bruce Banner helped reinvigorate interest in a comic series which had seen its popularity eclipsed by other Marvel heroes including Spider-Man and Iron Man . The 2008 release of The Incredible Hulk helped comic book fans once again familiarize
Britney Spears Debuts A New Look, Jennifer Lopez Gets Pranked By Her Daughter, And More
CW released a teaser trailer for their upcoming fall season featuring a number of your favorite CW characters. Watch the " Heroes Within" video below! [ YouTube ] Tagged: Britney Spears , Gone Girl , Headlines , Jennifer Lopez , kim kardashian , News
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TV Fanatic ] 3. Looks like we won't be seeing Sylar in next year's Heroes Reborn miniseries. Zachary Quinto announced he will not be returning to the Heroes franchise because he's "really interested in cultivating other experiences
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ninajacobson) June 21, 2014 2. The second trailer for the upcoming Teenage Mutant Ninja Turtles film has been released. The heroes in a half shell return to the big screen on August 8th. [ MTV ] 3. Demi Lovato has created a new plan to deal with insecurities
There's A 'Harry Potter' Reunion In The Works
making an appearance," Gilmore said. "Helena [Bonham-Carter] supports him as one of his team. And then we have our main heroes appear as well. You get to meet all the great characters from the stories." Unfortunately, we are unable to wave a magic
Is Captain America The Best Marvel Superhero Of All-Time?
sequel lives up to all the superhero hype. Despite our patriotic heroes superhuman deeds, Captain America's popularity among Marvel ..... darker Marvel superheros like Iron Man, or do you prefer your heroes a little less edgier like Captain America? Perhaps you share
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finally arrived, giving fans a glace at the 2014 version of our heroes in green. According to the official synopsis, the Ninja Turtles ..... your first look at the new Teenage Mutant Ninja Turtles movie ! Heroes in a half shell. Turtle power! This 2014 Michael Bay-produced
Russia Closes The Olympics By Poking Fun at Themselves, NBC's 'Heroes ' Returns, and More
the week with some pop culture news de jour. Heroes makes a surprising return to the NBC schedule ..... alone resurrection of the once popular series Heroes that is set to air in 2015. Heroes Reborn , as it will be known, will welcome back original
Disney Channel Set to Debut 'Descendants!' Check Out the Best Disney Movies of All-Time
Forget everything you thought you knew about heroes and villains. Casting is now underway for a new Disney Channel contemporary live-action movie titled Descendants that follows


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Rogar International 4156 Gourmet Rectangle Wood/Metal Pot Rack with Grid
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Product Description
Gourmet Rectangle Wood/Metal Pot Rack with Grid
- Select hardwoods enhanced with chrome, brass or copper corner brackets and accessories
- Gives kitchen a warm and homely feel
- 4 metal slats
- 4 corner brackets
- 4 ceiling hooks
- Care instruction: Dust, use soap/water and wood polish as necessary
- 4 pieces of 18" chain
- 8 butcher hooks
- 4 grid hooks
|Wood / Plated Steel
|9 Pounds
|Assembly Required
|Made in USA, Quick Ship
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Lovely fall signatures!
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Read a fantastic sci-fi space opera a few weeks ago. It's a series of books called the Expanse by James S.A. Corey and the first book is called Leviathan Wakes. Four books are out now with a total of...
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Cardinal Ratzinger, as Prefect and Theologian
Mark Brumley on the Writings of a Future Pope
NAPA, California, APRIL 27, 2005 (Zenit) - In Benedict XVI we are blessed with a theologian and pastor who has thought and prayed long and hard about Jesus Christ, the Church and its mission to the world.
So says Mark Brumley, president of Ignatius Press, which is the primary publisher of the English-language editions of Cardinal Ratzinger's works.
Brumley shared with us how the German cardinal engaged in the sophisticated work of a theologian while he held a high ecclesiastical office, and why he may be one of the greatest theologians of our time.
Q: What are some of the most remarkable contributions that Cardinal Ratzinger made to theology over the last 20-some years as prefect for the Congregation for the Doctrine of the Faith?
Brumley: It's important to distinguish between Cardinal Ratzinger's work as prefect of the Congregation for the Doctrine of Faith and his work as a theologian.
His contributions to theology as prefect of the CDF are different in kind from his contributions as a theologian, even though they both obviously agree with Catholic teaching.
As prefect of the CDF, he issued documents that are part of the Church's Spirit-guided magisterium. Catholics are to receive and accept this teaching as authentic Catholic teaching. These documents are more than a mere theologian's contribution to theology.
At the same time, since theologians don't have access to divine Revelation apart from how it has been expressed in the divinely inspired Scripture and the Spirit-assisted Tradition as interpreted by the magisterium, the ongoing work of the magisterium by definition "contributes to theology."
Responsible theologians make use of magisterial teaching in order reasonably and systematically to reflect on what God has revealed. So the work of the prefect of the CDF does, in fact, "contribute to theology."
That said, Cardinal Ratzinger has continued to publish theological works apart from exercising the authority of his CDF office. Some of these works closely relate to certain documents and concerns of the CDF.
For example, his book "The Nature and Mission of Theology" is tied to the CDF document "The Ecclesial Vocation of the Theologian," among other things. His book "Called to Communion" contains first-rate theological discussions of the nature of the Church, the papacy, and the hotly disputed theological issue of the relationship between the local diocesan Church and the universal Church.
Likewise, his recent book "Truth and Tolerance,� which deals with Christianity and non-Christian religions, provides the reflections of Ratzinger the theologian on Church teaching contained in the document "Dominus Iesus," issued by Ratzinger the prefect of the CDF.
As is appropriate for the work of a theologian, "Truth and Tolerance" amplifies and goes deeper than what is contained in "Dominus Iesus," which simply restates Church teaching that is binding on Catholics.
Q: What will Pope Benedict XVI bring of himself and his theological interests to the pontificate?
Brumley: Although Ratzinger the prefect is distinguishable from Ratzinger the theologian, we are blessed in Pope Benedict XVI with a theologian and pastor who has thought and prayed long and hard about Jesus Christ, the Church and her mission to the world.
He will, I believe, continue the twofold task of Vatican II -- renewing the inner life of the Church and reinvigorating the Church's mission in the world. He is committed to a renewal of biblical studies and a deepening of ordinary Catholics' appreciation of and participation in the sacred liturgy.
He staunchly proclaims the universal call to holiness of Vatican II. He understands the importance of dialogue among Christians and dialogue with world religions and seekers, while he upholds the integrity of Catholic faith and insists on a renewed missionary drive to spread the gospel of Jesus Christ to the world.
And he knows that in the areas of morality and social justice, the Christian message has not been tried and found wanting, as G.K. Chesterton noted, but has been found difficult and left untried. Furthermore, he sees the threat of radical relativism and many other "isms."
Q: What have you thought of Cardinal Ratzinger's writings over the years?
Brumley: My reading of his writings has led me to think that he is one of the greatest theologians of our time. His writings reflect his commitment to a living Catholic tradition, an understanding of the faith that is ever ancient and ever new.
It is remarkable that we have a Pope who has written so much prior to becoming Pope. Also remarkable is the fact that, while he has held a high ecclesiastical office, he has at the same time ...
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We stayed 2 nights in this hotel in September 2014 while visiting Venice on a European road trip. It is a small family owned hotel on a flower farm. The farm is beautiful with flowers, horses and birds. The hotel is very clean and modern. There is plenty of parking spaces for guests. It is a short drive to many restaurants, towns and the train station. The train ride to Venice is about 30 minutes. Parking at the train station is free. The rooms are spacious and comfortable. Florian, the owner is very helpful and friendly. We enjoyed our stay there and found it to be a good value. Jim & Lynda S. Columbia, Maryland USA
Hotel qui répond à nos attentes...un lit et une salle de bain...le petit dejeuner est pour moi inexistant mais l'hotel est tellement bien situé que ce n'est pas un problème : à 30 secondes à pieds d'un arret bateau, 5mn du Rialto, une position quasi centrale idéale.Très facile d'accès depuis l'aéroport. un petit frigo à disposition dans la chambre pratique. Si je retourne à Venise, ce sera dans cet hotel.
Ci siamo trovati molto bene. Il proprietario è davvero molto gentile
Signora gentile, locali di buon livello.
I was here for the fifth time... and I am sure, it was not the last time... Great stay, nice and clean, nice host, close to the Vaporetto-station, just 5 minute walk to the rialto bridge... what else will You aspect?
Very very nice reception , 2 immaculate bathrooms , nice bedrooms , air conditionned , who could ask for anything more ?
molto bello , molto pulito, non manca nulla
Ottimo rapporto qualità prezzo. Posizione comoda per visitare anche le città limitrofe, facilmente raggiungibili con qualsiasi mezzo: Venezia, Verona, Vicenza, Rovigo ecc
Great place
I was there in September, this year (2012) - the second time.... I love the service by Nicola, i love to stay close to the Vaporetto-Station Sant Stae, to all the beautiful places like Palazzo Mocenigo, the Chiesa di San Stae, - and the nice, friendly and helping hand of Nicola. Thank you so much- I´d love to come back to venice soon and to be Your guest again....
We stayed for 5 days at Ca Florian and had a great week. The rooms where very clean and luxurious with sat tv, airco, minibar, wifi. The staff is also very helpfull and friendly. In this week we went to Venice, Verona, the Garda Lake, Asolo, Castelfranco, etc. So you can imagine that we were gone the whole day and came back late. All was no problem and the rooms were cleaned when we came back with nice clean sheeds and towels. The breakfast is simpel, but ok. There is no option for diner, but we were gone all day, so no problem for us. We would recommend Ca Florian to everyone!
Ce B&B est très bien situé et peu onéreux, hors saison en tout cas (45 €/ nuit fin novembre) ! Les chambres sont grandes, propres et agréables. Le petit déjeuner est élémentaire (café soluble, évier et réfrigérateur dans la chambre) mais il y a plusieurs cafés dans le quartier, à proximité. Le quartier est très calme et le jeune propriétaire très sympathique et accueillant ! Vraiment une excellente surprise et un très bon souvenir de ces quelques jours pour notre lune de PACS, n'hésitez pas ! Pierre et Samantha
ottimo.. pulito, gentili, ben curato.. e le indicazioni per girare venezia sono dvvero utili e ben studiate, Grazie..
My 101 year old father, my 23 year old son, and I stayed in one room. Though there was no air conditioning, the weather was mild and with the window open, we were still able to sleep well. The host and his family live on the ground floor. We met him twice, to make payment and to get some information about staying there, internet access, etc. So, if you don't want much interaction with Italians, this is the place for you. It's a very convenient location, easy access to the Vaporetto (water bus), and to many places in the city. I recommend this place if you're looking for a room with a bathroom.
The place has a good location, is possible to go everywhere just walking. They give you a map with some few instructions for tourists, very helpful if you don't know Venice. And they also give you free pear juice and tea, which is great cause is a cortesy. The owner Luca was extremely helpful and the price very reasonable. Highly recommend it!
Very new location clean. My room has got niec and great bathroom.
This was a quiant wonderful place to stay. The owner's wife was very accomodating, and seeing as it was my first time in Venice she wanted to make sure I knew where to shop. She also told me where all my personal destinations were. The room was beautiful and a great place to relax. Very clean and comfortable. I would definitely reccommend it to someone not wanting to stay in a busy cookie cutter hotel. I hope to be coming back. Jennifer Koskie Provo, UT USA
Amazing place to stay in Venice! Great location in S. Croce close to Rialto Bridge and S. Stae vaporetto stop, easy walking distances to every major site in Venice. Our room was very clean and pretty, towels and linen were also provided. Mr Nicolas was fantistic host, I this hostel to anyone staying in Venice!