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1-10 of 205 properties for sale found
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5 bedroom detached house for sale Tanworth Lane, Shirley, Solihull, West Midlands, B90
Enchanting Grade II Listed Country Residence With Separate One Bedroom Cottage and Luxurious Office/Leisure Suite. (Around 8,029 Sq. Ft In Total). Around 4 Acres. Dining Hall, Sitting Room, Living Room, Office/2nd Sitting Room, Kitchen, Utility Room, Cellars, Lobby, Cloakroom, (contd...) More details ›
Reduced on 18/06/2014 by Andrew Grant, Country Homes. Call: 01905 939067 Local call rate
£1,700,000 Guide Price
Guide Price £1,700,000
6 bedroom detached house for sale Tanworth Lane, Solihull
* Charming Grade II Listed residence in a lovely countryside location * Spacious detached one bedroom cottage (1152 sq.ft) * Well-appointed versatile barn * 5 Bedrooms * Master with dressing & ensuite * 4 Reception rooms * Gardens & grounds extending to around 4 acres * Extensive outbuil... More details ›
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Restaurant for sale Freehold Vacant Drive Thru Restaurant at 276,Stratford Road,Shirley,Solihull,B903AD
The property is arranged on ground floor to provide a driver thru restaurant with kitchen, Preparation area, with stock room, staff room and training room.The building comprises 3830 sq. ft. with parking for 33 marked spaces including 3 disabled bays More details ›
7 bedroom detached house for sale Birchy Leasowes Lane, Shirley, Solihull, West Midlands
R A Bennett & Partners are proud to present this luxury detached house * Spacious living room * Dining room * Magnificent breakfast kitchen with large family area * 7 bedrooms * 1 family bathroom with separate double walk in shower * 3 Ensuites * Double garage * Parking for 2 cars * (contd...) More details ›
£900,000 Guide Price
Guide Price £900,000
Land for sale Stratford Road, Shirley, Solihull
INVESTMENT OPPORTUNITYLand and Buildings for SalePotential Development OpportunitySite area of approximately 0.37 acresLapsed detailed consent for 12 apts and 2 townhouses ref No 2007/2155Excellent location in sought after area of the town adjacent to the regeneration area suitable More details ›
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Light Industrial for sale Lancaster House, Drayton Road (Off Highlands Road), Solihull, B90 4NG
The property is of steel portal frame construction with brick walls to the eaves and a dual pitched roof over incorporating NATURAL LIGHTS. Internally, there is a double storey OFFICE ACCOMMODATION with KITCHEN and sanitary facilities. The warehouse area benefits from 2 level access LOADING DOORS. More details ›
4 bedroom detached house for sale Houndsfield Lane, Tidbury Green
An individual four double bedroom detached house on a 0.35 acre plot, located in a lovely semi rural location. Delightful living room with log burner, dining room and conservatory, kitchen/ breakfast room, laundry, study, covered hot tub area with heated dressing room and a delightful rear garden... More details ›
5 bedroom detached bungalow for sale Lady Lane, Shirley
Situated in a delightful semi-rural location a very spacious detached dormer style bungalow with fantastic potential, having enclosed porch, dining room with hallway off, study, attractive living room with log burner, kitchen, sitting room, two ground floor double bedrooms; master with dressing r... More details ›
5 bedroom detached house for sale Birchy Close, Dickens Heath, Solihull
A beautifully presented, spacious four/five double bedroom detached residence situated in a sought after area with open views to the rear. The property offers excellent family living accommodation which briefly comprises; enclosed entrance porch, L shaped reception hall, guest cloakroom/wc, study... More details ›
5 bedroom detached house for sale PLOT 1, BIRCHY GREENS
NOW SELLING OFF PLAN!!! REGISTER YOUR EARLY INTEREST TODAY!!! Enjoying a sought-after and semi-rural setting, 'Birchy Greens' is our latest luxury development of just three, 5 bedroom detached family homes and two, 3 bedroom detached dormer bungalows. More details ›
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Apparently UFC light heavyweight champ and pound-for-pound kingpin Jon Jones believes in superstition—particularly when it pertains to his pre-fight rituals. "I would never bring my belt out to the c read news >>
The two most recognizable brands in Asian MMA teamed up for a press conference recently at the grand opening of the brand new Evolve MMA academy on Singapore's upscale Orchard Road. read news >>
Wanderlei Silva has unleashed another video, where he claims the UFC threatened to sue him, he apologizes to Cain Velasquez, and much more. read news >>
Who deserves the next UFC featherweight title shot? According to a recent UFC poll, it's Frankie Edgar, not Conor McGregor. Frankie Edgar's victory at UFC Fight Night 57 was the kind of performance t read news >>
"I am retired, I don't fight anymore, I lost the desire. So what stops me from generating income now? Are these people going to keep threatening me? They'll keep coming to sue me every time I work wi read news >>
Four of the world's top middleweight fighters are scheduled to compete at February's UFC 184 event. If anyone's unable to make the date, Luke Rockhold said he'll be ready to fill the void.Filed under read news >>
Event preview and live stream of the 2014 Judo Grand Prix taking place in Jeju, South Korea by BE's resident Judo bum read news >>
While inconsistency has plagued Daniel Swain over the past two years, he could have very much put himself back on track with a 67-second win in his most recent bout. read news >>
Paige VanZant made a successful Octagon debut at UFC Fight Night 57 by defeating Kailin Curran via third-round technical knockout (TKO) in Austin, Texas (recap) on Nov. 22, 2014. In doing so, not onl read news >>
Wanderlei Silva is at it again with another video blasting the UFC. This time, his monologue was mostly about his assertion that the UFC threatened to sue him if he appeared at a Bellator fan event e read news >>
Paige VanZant may only have one fight in the UFC to date, but it sounds like she has a good idea of who she'd like to fight next. Practically every fighter has that one loss they'd love to get back, read news >>

subset: commoncrawl


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The Republicans went to the Supreme Court to let them decide what is constitutional. If Bush did something unconstitutional, then why didn't the Democrats do the same????? Better yet, why didn't big ears himself rescind this so-called unconstitutional act? He had the power of the House for a couple of years there, but instead, was so insistent that he shove this miserable Unaffordable Care Act down our throats that he didn't seem to care now did he?<quoted text>
Your valiant fight for the Constitution would sound oh so sincere if it wasn't for the fact that your team was waving flags with Bibles in hand when the most unconstitutional act in the history of this country took place. It's called the Patriot Act. It came from the same guy who had secret torture camps. You know, real "only party with morals" kinda stuff.
The Republicans voted over 40 times to get rid of Commie Care. That's the way we do things in this country. Of course it was shot down every time, and now look at the mess we have on our hands. Five million people and growing that lost their health insurance coverage so far.


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Protein–protein interaction prediction
Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions between pairs or groups of proteins. Understanding protein–protein interactions is important for the investigation of intracellular signaling pathways, modelling of protein complex structures and for gaining insights into various biochemical processes. Experimentally, physical interactions between pairs of proteins can be inferred from a variety of experimental techniques, including yeast two-hybrid systems, protein-fragment complementation assays (PCA), affinity purification/mass spectrometry, protein microarrays, fluorescence resonance energy transfer (FRET), and Microscale Thermophoresis (MST). Efforts to experimentally determine the interactome of numerous species are ongoing, and a number of computational methods for interaction prediction have been developed in recent years.
- 1 Methods
- 1.1 Phylogenetic profiling
- 1.2 Prediction of co-evolved protein pairs based on similar phylogenetic trees
- 1.3 Rosetta stone method
- 1.4 Classification methods
- 1.5 Inference of interactions from homologous structures
- 1.6 Association methods
- 1.7 Identification of structural patterns
- 1.8 Bayesian network modelling
- 1.9 Domain-pair exclusion analysis
- 1.10 Supervised learning problem
- 2 Relationship to docking methods
- 3 See also
- 4 References
- 5 External links
Proteins that interact are more likely to co-evolve,[1][2][3][4] therefore, it is possible to make inferences about interactions between pairs of proteins based on their phylogenetic distances. It has also been observed in some cases that pairs of interacting proteins have fused orthologues in other organisms. In addition, a number of bound protein complexes have been structurally solved and can be used to identify the residues that mediate the interaction so that similar motifs can be located in other organisms.
Phylogenetic profiling[edit]
Phylogenetic profiling[5] finds pairs of protein families with similar patterns of presence or absence across large numbers of species. This method is based on the hypothesis that potentially interacting proteins should co-evolve and should have orthologs in closely related species. That is, proteins that form complexes or are part of a pathway should be present simultaneously in order for them to function. A phylogenetic profile is constructed for each protein under investigation. The profile is basically a record of whether the protein is present in certain genomes. If two proteins are found to be present and absent in the same genomes, those proteins are deemed likely to be functionally related. A similar method can be applied to protein domains, where profiles are constructed for domains to determine if there are domain interactions. Some drawbacks with the phylogenetic profile methods are that they are computationally expensive to perform, they rely on homology detection between distant organisms, and they only identify if the proteins being investigated are functionally related (part of complex or in same pathway) and not if they have direct interactions.
Prediction of co-evolved protein pairs based on similar phylogenetic trees[edit]
It was observed that the phylogenetic trees of ligands and receptors were often more similar than due to random chance.[4] This is likely because they faced similar selection pressures and co-evolved. This method[6] uses the phylogenetic trees of protein pairs to determine if interactions exist. To do this, homologs of the proteins of interest are found (using a sequence search tool such as BLAST) and multiple-sequence alignments are done (with alignment tools such as Clustal) to build distance matrices for each of the proteins of interest.[4] The distance matrices should then be used to build phylogenetic trees. However, comparisons between phylogenetic trees are difficult, and current methods circumvent this by simply comparing distance matrices[4]. The distance matrices of the proteins are used to calculate a correlation coefficient, in which a larger value corresponds to co-evolution. The benefit of comparing distance matrices instead of phylogenetic trees is that the results do not depend on the method of tree building that was used. The downside is that difference matrices are not perfect representations of phylogenetic trees, and inaccuracies may result from using such a shortcut.[4] Another factor worthy of note is that there are background similarities between the phylogenetic trees of any protein, even ones that do not interact. If left unaccounted for, this could lead to a high false-positive rate. For this reason, certain methods construct a background tree using 16S rRNA sequences which they use as the canonical tree of life. The distance matrix constructed from this tree of life is then subtracted from the distance matrices of the proteins of interest.[7] However, because RNA distance matrices and DNA distance matrices have different scale, presumably because RNA and DNA have different mutation rates, the RNA matrix needs to be rescaled before it can be subtracted from the DNA matrices.[7] By using molecular clock proteins, the scaling coefficient for protein distance/RNA distance can be calculated.[7] This coefficient is used to rescale the RNA matrix.
Rosetta stone method[edit]
A Rosetta stone protein is a protein chain composed of two fused proteins. It is observed that proteins or domains that interact with one another tend to have homologs in other genomes that are fused into a Rosetta stone protein.[2] It is thought that the fusion helps optimize the co-expression of these proteins. The most obvious drawback of this method is that there are many protein interactions that cannot be discovered this way; it relies on the presence of Rosetta stone proteins. Also, like phylogenetic profile methods, the Rosetta stone method does not necessarily find interacting proteins, as there can be other reasons for the fusion of two proteins.
Classification methods[edit]
Classification methods use data to train a program (classifier) to distinguish positive examples of interacting protein/domain pairs with negative examples of non-interacting pairs. Popular classifiers used are Random Forest Decision (RFD) and Support Vector Machines. RFD produces results based on the domain composition of interacting and non-interacting protein pairs. When given a protein pair to classify, RFD first creates a representation of the protein pair in a vector.[8] The vector contains all the domain types used to train RFD, and for each domain type the vector also contains a value of 0, 1, or 2. If the protein pair does not contain a certain domain, then the value for that domain is 0. If one of the proteins of the pair contains the domain, then the value is 1. If both proteins contain the domain, then the value is 2.[8] Using training data, RFD constructs a decision forest, consisting of many decision trees. Each decision tree evaluates several domains, and based on the presence or absence of interactions in these domains, makes a decision as to if the protein pair interacts. The vector representation of the protein pair is evaluated by each tree to determine if they are an interacting pair or a non-interacting pair. The forest tallies up all the input from the trees to come up with a final decision.[8] The strength of this method is that it does not assume that domains interact independent of each other. This makes it so that multiple domains in proteins can be used in the prediction.[8] This is a big step up from previous methods which could only predict based on a single domain pair. The limitation of this method is that it relies on the training dataset to produce results. Thus, usage of different training datasets could influence the results.
Inference of interactions from homologous structures[edit]
This group of methods[9][8][10][11][12][13] makes use of known protein complex structures to predict and structurally model interactions between query protein sequences. The prediction process generally starts by employing a sequence based method (e.g. Interolog) to search for protein complex structures that are homologous to the query sequences. These known complex structures are then used as templates to structurally model the interaction between query sequences. This method has the advantage of not only inferring protein interactions but also suggests models of how proteins interact structurally, which can provide some insights into the atomic level mechanism of that interaction. On the other hand, the ability for these methods to make a prediction is constrained by a limited number of known protein complex structures.
Association methods[edit]
Association methods look for characteristic sequences or motifs that can help distinguish between interacting and non-interacting pairs. A classifier is trained by looking for sequence-signature pairs where one protein contains one sequence-signature, and its interacting partner contains another sequence-signature.[14] They look specifically for sequence-signatures that are found together more often than by chance. This uses a log-odds score which is computed as log2(Pij/PiPj), where Pij is the observed frequency of domains i and j occurring in one protein pair; Pi and Pj are the background frequencies of domains i and j in the data. Predicted domain interactions are those with positive log-odds scores and also having several occurrences within the database.[14] The downside with this method is that it looks at each pair of interacting domains separately, and it assumes that they interact independently of each other.
Identification of structural patterns[edit]
This method[15][16] builds a library of known protein–protein interfaces from the PDB, where the interfaces are defined as pairs of polypeptide fragments that are below a threshold slightly larger than the Van der Waals radius of the atoms involved. The sequences in the library are then clustered based on structural alignment and redundant sequences are eliminated. The residues that have a high (generally >50%) level of frequency for a given position are considered hotspots.[17] This library is then used to identify potential interactions between pairs of targets, providing that they have a known structure (i.e. present in the PDB).
Bayesian network modelling[edit]
Bayesian methods[18] integrate data from a wide variety of sources, including both experimental results and prior computational predictions, and use these features to assess the likelihood that a particular potential protein interaction is a true positive result. These methods are useful because experimental procedures, particularly the yeast two-hybrid experiments, are extremely noisy and produce many false positives, while the previously mentioned computational methods can only provide circumstantial evidence that a particular pair of proteins might interact.[19]
Domain-pair exclusion analysis[edit]
The domain-pair exclusion analysis[20] detects specific domain interactions that are hard to detect using Bayesian methods. Bayesian methods are good at detecting nonspecific promiscuous interactions and not very good at detecting rare specific interactions. The domain-pair exclusion analysis method calculates an E-score which measures if two domains interact. It is calculated as log(probability that the two proteins interact given that the domains interact/probability that the two proteins interact given that the domains don't interact). The probabilities required in the formula are calculated using an Expectation Maximization procedure, which is a method for estimating parameters in statistical models. High E-scores indicate that the two domains are likely to interact, while low scores indicate that other domains form the protein pair are more likely to be responsible for the interaction. The drawback with this method is that it does not take into account false positives and false negatives in the experimental data.
Supervised learning problem[edit]
The problem of PPI prediction can be framed as a supervised learning problem. In this paradigm the known protein interactions supervise the estimation of a function that can predict whether an interaction exists or not between two proteins given data about the proteins (e.g., expression levels of each gene in different experimental conditions, location information, phylogenetic profile, etc.).
Relationship to docking methods[edit]
The field of protein–protein interaction prediction is closely related to the field of protein–protein docking, which attempts to use geometric and steric considerations to fit two proteins of known structure into a bound complex. This is a useful mode of inquiry in cases where both proteins in the pair have known structures and are known (or at least strongly suspected) to interact, but since so many proteins do not have experimentally determined structures, sequence-based interaction prediction methods are especially useful in conjunction with experimental studies of an organism's interactome.
See also[edit]
- Interactome
- Protein–protein interaction
- Macromolecular docking
- Protein–DNA interaction site predictor
- Two-hybrid screening
- Protein structure prediction software
- FastContact
- ^ Dandekar T., Snel B.,Huynen M. and Bork P. (1998) "Conservation of gene order: a fingerprint of proteins that physically interact." Trends Biochem. Sci. (23),324-328
- ^ a b Enright A.J.,Iliopoulos I.,Kyripides N.C. and Ouzounis C.A. (1999) "Protein interaction maps for complete genomes based on gene fusion events." Nature (402), 86-90
- ^ Marcotte E.M., Pellegrini M., Ng H.L., Rice D.W., Yeates T.O., Eisenberg D. (1999) "Detecting protein function and protein-protein interactions from genome sequences." Science (285), 751-753
- ^ a b c d e Pazos F., Valencia A. (2001). "Similarity of phylogenetic trees as indicator of protein-protein interaction." Protein Engineering, 9 (14), 609-614
- ^ Pellegrini M, Marcotte EM, Thompson MJ, Eisenberg D, Yeates TO. (1999) "Assigning protein functions by comparative genome analysis: protein phylogenetic profiles." Proc Natl Acad Sci U S A., 96, 4285-8
- ^ Tan S.H., Zhang Z., Ng S.K. (2004) "ADVICE: Automated Detection and Validation of Interaction by Co-Evolution." Nucl. Ac. Res., 32 (Web Server issue):W69-72.
- ^ a b c Pazos F, Ranea JA, Juan D, Sternberg MJ (2005) Assessing protein coevolution in the context of the tree of life assists in the prediction of the interactome. J Mol Biol 352: 1002–1015.
- ^ a b c d e Chen XW, Liu M (2005) Prediction of protein–protein interactions using random decision forest framework. Bioinformatics 21: 4394–4400.
- ^ Aloy P., and R. B. Russell. (2003) "InterPreTS: protein Interaction Prediction through Tertiary Structure". Bioinformatics, 19 (1), 161-162.
- ^ Fukuhara, Naoshi, and Takeshi Kawabata. (2008) "HOMCOS: a server to predict interacting protein pairs and interacting sites by homology modeling of complex structures" Nucleic Acids Research, 36 (S2): 185-.
- ^ Kittichotirat W, M Guerquin, RE Bumgarner, and R Samudrala (2009) "Protinfo PPC: a web server for atomic level prediction of protein complexes" Nucleic Acids Research, 37 (Web Server issue): 519-25.
- ^ Shoemaker BA, Zhang D, Thangudu RR, Tyagi M, Fong JH, Marchler-Bauer A, Bryant SH, Madej T, Panchenko AR (2010) Inferred Biomolecular Interaction Server--a web server to analyze and predict protein interacting partners and binding sites. Nucleic Acids Res. 2010 Jan;38(Database issue):D518-24. url:http://www.ncbi.nlm.nih.gov/pubmed/19843613
- ^ Esmaielbeiki R, Nebel J-C (2014) Scoring docking conformations using predicted protein interfaces. BMC Bioinformatics, 15:171.
- ^ a b Sprinzak E, Margalit H (2001) Correlated sequence-signatures as markers of protein–protein interaction. J Mol Biol 311: 681–692.
- ^ Aytuna A. S., Keskin O., Gursoy A. (2005) "Prediction of protein-protein interactions by combining structure and sequence conservation in protein interfaces." Bioinformatics, 21 (12), 2850–2855
- ^ Ogmen U., Keskin O., Aytuna A.S., Nussinov R. and Gursoy A. (2005) "PRISM: protein interactions by structural matching." Nucl. Ac. Res.,33 (Web Server issue):W331-336
- ^ Keskin O., Ma B. and Nussinov R. (2004) "Hot regions int protein-protein interactions: The organization and contribution of structurally conserved hot spot residues" J. Mol. Biol., (345),1281–1294
- ^ Jansen R, Yu H, Greenbaum D, Kluger Y, Krogan NJ, Chung S, Emili A, Snyder M, Greenblatt JF, Gerstein M. (2003) A Bayesian networks approach for predicting protein-protein interactions from genomic data." Science, 302(5644):449-53.
- ^ Zhang QC, Petrey D, Deng L, Qiang L, Shi Y, Thu CA, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, Honig B (2012) "Structure-based prediction of protein-protein interactions on a genome-wide scale" Nature, 490(7421):556-60
- ^ Shoemaker BA, Panchenko AR (2007) Deciphering protein–protein interactions. Part II. Computational methods to predict protein and domain interaction partners. PLoS Comput Biol 3(4): e43.
External links[edit]
|This article's use of external links may not follow Wikipedia's policies or guidelines. (December 2012)
- 3D-Partner
- cons-PPISP
- GeneMANIA
- Human Protein-Protein Interaction Prediction (PIPs)
- InterPreTS
- InterProSurf
- metaPPI (combining the power of cons-PPISP, PINUP, Promate, SPPIDER and PPI_PRED
- PatchDock
- Protein Lounge
- Protinfo PPC
- FunCoup
- ProtCID: the Protein Common Interface Database
- MirrorTree
- IBIS-Inferred Biomolecular Interaction Server
- esyN


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AH Research • Fri, Oct. 31
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Be smarter and faster with PRO Alerts on CYS
Albert Alfonso • Tue, Oct. 21 • 3 Comments
Albert Alfonso • Wed, Sep. 10 • 7 Comments
Equity Watch • Thu, Aug. 21 • 2 Comments
From other sites
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at CNBC.com (Nov 8, 2012)
at CNBC.com (Sep 11, 2012)
at MarketWatch.com (Jul 11, 2012)
at CNBC.com (Dec 16, 2011)
at CNBC.com (Dec 14, 2011)
at CNBC.com (Jun 1, 2011)
CYS Earns Neutral Thesis With Its Defensive ApproachAH Research • Fri, Oct. 31
- CYS has not been able to take advantage of lower interest rate scenario.
- High hedging cost and low dollar income have lowered estimate of core EPS and dollar income to $0.30 per share.
- Company has taken right steps by increasing portfolio allocation to high-yielding 30-year MBS in the third quarter.
13.45% Dividend CYS Investments Put In A Ho-Hum Q3; But It Still Pays A Still Great DividendDavid White • Thu, Oct. 23 • 3 Comments
- CYS reported a slight book value loss from $10.31 to $10.14 (or $0.17 per share). This was largely expected.
- CYS declared a $0.30 per share dividend for Q3. This was down slightly from the $0.32 per share dividend in Q2 2014. The dividend is still great at 13.45% annually.
- The 10 year US Treasury Note yield has fallen -27 bps from Q3E 2014 to October 22, 2014. This means a book value gain thus far in Q4 2014.
Update: CYS Investments Posts An In-Line QuarterAlbert Alfonso • Tue, Oct. 21 • 3 Comments
- CYS sees a small 1.6% decline in book value for Q3 2014 to $10.14.
- Core income plus drop income declines two pennies to $0.31 per share.
- These results are likely due to CYS increasing its hedges during the quarter.
- At current prices, CYS yields 13.40% and trades at a 12% discount to book value.
- I remain bullish CYS and the mREIT sector overall due to the large yields offered and discounts to book value.
Update: CYS Investments Reports Q3 Earnings - The Good, The Bad And The UglyChristopher F. Davis • Mon, Oct. 20 • 13 Comments
- CYS Investments just reported Q3 earnings, which had few strengths and saw multiple key metrics worsen quarter-over-quarter.
- I recently opined that CYS was to be avoided in favor of AGNC, NLY and WMC, as CYS' performance was a concern.
- The present news reinforces my outlook of CYS relative to its competitors, and has turned me from neutral to bearish on CYS.
Oversold, 14% Dividend Payer CYS Investments Looks AttractiveDavid White • Fri, Oct. 10 • 16 Comments
- CYS had a total economic return of 9.8% for Q2 2014 alone (dividend + book value gain).
- CYS likely lost a small amount of book value in Q3 2014, but it will still pay its great dividend.
- The spike in bond yields (fall in bond prices) was short lived; and they have now retraced. This makes CYS a much safer investment.
- I have yet to opine on CYS Investments.
- I compare the key metrics of CYS to those of its largest competitors.
- CYS trades at an 18% discount-to-book; is it warranted?
Move On CYS Investments' Quarterly Dividend, 13% Yield And Future OpportunityTom Dorsey • Thu, Sep. 11 • 1 Comment
- Dividend payout dropped from $0.32 to $0.30 for the quarter, but within the REIT requirement of 90%.
- The book price has steadily risen to $10.31, $0.63 over first quarter 2014.
- 2015 may be the year of interest rate increases, but the future will bring stock price appreciations and bigger dividends.
Update: CYS Investments Lowers The DividendAlbert Alfonso • Wed, Sep. 10 • 7 Comments
- CYS declares a $0.30 per share quarterly dividend,.
- This is a small decrease from last quarter's dividend of $0.32 per share.
- The decrease may be a result of weakening net interest margins in the MBS market.
- I remain bullish CYS due to its large discount to book value and robust yield.
CYS Takes The Right StepsEquity Watch • Thu, Aug. 21 • 2 Comments
- Move to increase exposure to high yield agency MBS will improve asset portfolio yield and net interest spread.
- Increase in swaps exposure will provide better cash flow hedge for CYS.
- Repositioning of investment and hedge portfolio will protect book value and portend well for valuations.
CYS Fails To Deliver In Q2 Earnings; Defensive Portfolio Approach Earns Neutral RatingAH Research • Tue, Jul. 22 • 7 Comments
- Company needs to give up defensive approach and divert its resources to high yielding assets.
- Initiatives need to be taken to enhance asset yield.
- CYS should also re-structure its hedged positions according to labor market conditions.
Update: CYS Investments Earnings - Posts A Massive Book Value IncreaseAlbert Alfonso • Tue, Jul. 22 • 12 Comments
- CYS Investments sees a large 7% Q/Q increase in book value for Q2 2014.
- Core income also held steady, likely meaning no need for a dividend cut.
- As I noted in a previous article, CYS bottomed late last year and should start trading closer to its book value of $10.31 per share.
- I remain bullish CYS and the mREIT sector overall with a few exceptions.
CYS Investments' Large Book Value Gain In Q2 Bodes Well For Annaly Capital ManagementDavid White • Tue, Jul. 22 • 3 Comments
- CYS reported a book value gain of +$0.63 for Q2 2014. It had a dividend of $0.32 per common share (14.2% annually).
- CYS had a total economic return for Q2 2014 alone of $0.95 per common share or +9.81%.
- NLY should have a book value gain too for Q2 2014. This article goes over the details.
Sustainable High Dividend Yield Attracts Investors To CYS Despite Worrying StrategiesAH Research • Fri, Jul. 18 • 10 Comments
- Neutral thesis on CYS due to weak growth prospects given its high exposure in agency RMBS.
- Defensive approach needs to be better managed to tackle interest rate scenario.
- Company needs to diversify portfolio mix to enhance asset yield.
Double-Digit Return On CYS Investments Even BetterTom Dorsey • Tue, Jul. 15 • 8 Comments
- CYS to pay dividend on July 16, 2014.
- Dividend return 14% and opportunity to receive better return.
- CYS stock price is down, and now is a great buy-in opportunity.
- Interest Rate Risk effects and profitability.
13.9% Div. CYS Investments And 18.4% Div. Western Asset Mortgage Capital Are Winning Their BetsDavid White • Fri, Jun. 20 • 33 Comments
- Both CYS and WMC employed strategies in Q2 2014 that would perform well if interest rates went down.
- 10 year US Treasury Note yields as of June 19, 2014 were down -11 bps since March 31, 2014.
- CYS pays a 13.9% dividend, and WMC pays an 18.4% dividend. How reliable are these?
- What risks are CYS and WMC taking to outperform most other primarily Agency mortgage REITs?
CYS Investments: Another REIT With Core Earnings Up And Increasing Book PriceTom Dorsey • Thu, Jun. 5 • 8 Comments
- We anticipate strong dividend for the second quarter.
- We anticipate stock price will continue to appreciate through 2014.
- It has seen its book value increase, and is still at discount of .93.
- CYS Investments remains the highest dividend paying company in the industry; paying nearly 15% in dividends annually.
- CYS was on another level in the first quarter, posting the best economic returns.
- CYS remains undervalued, trading at 90% of book.
- CYS reduced leverage, but still had an interest rate spread net of hedge, including drop income of 1.89%.
American Capital And CYS Both Posted Great Q1 2014 Results - CYS Seems To Have Led The WayDavid White • Mon, May. 5 • 5 Comments
- CYS had a Q1 2014 economic return of 8.2%. This was comprised of a $0.32 per share dividend and a $0.44 increase in book value.
- AGNC had a Q1 2014 economic return of 5.1%. This was comprised of a $0.65 per share dividend and a $0.56 increase in book value.
- CYS ended Q1 2014 with leverage of 6.32x. It had a net interest rate spread of 1.89% and a CPR of 5.6% for Q1.
- AGNC ended Q1 2014 with leverage of 7.6x. It had a net interest rate spread of 1.43% and a CPR of 7.0% for Q1.
- CYS beat AGNC in performance in Q1 2014, but AGNC may be significantly safer.
CYS Investments: Potential Total Return Of 20% Makes An Ideal BuyEquity Watch • Wed, Mar. 19 • 8 Comments
- High dividend yield of 14.3% and price appreciation of 5% other key factors for bullish thesis on company.
- CYS protecting its book value by increasing its exposure to 15-year fixed rate assets in favor of 30-year fixed rate assets.
- Share buybacks undertaken by company also likely to portend well for earnings and book value.
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Thu, Jan. 30, 10:20 AM
- You're seeing a lot of demand in the assets we hold, says Capstead Mortgage (CMO +1.5%) management on the conference call after reporting a blowout Q4. In a steepening yield curve environment - the short-end anchored while long rates move higher - Capstead is benefitting from tightening spreads in the 5/1 ARMs it mostly holds.
- Mr. Market seems to have fleshed this out, and Capstead was already trading for right around book value (reported at $12.47 as of Dec. 31) vs. the double-digit discounts for long-end players like Annaly (NLY +0.2%), American Capital (AGNC -0.3%), Armour (ARR), and CYS Investments (CYS -0.5%).
- Another in the adjustable-rate arena is Hatteras Financial (HTS +1.5%).
- Related ETFs: REM, MORT, MORL
Thu, Jan. 23, 2:23 PM
- One sector nearly fully in the green on a big down day for the broad averages is the mortgage REITs (REM +0.6%) as investors - worried about further declines in book value - take comfort from a big 10 basis point dip in the 10-year Treasury yield to 2.76% (off from 3% at the start of the year).
- Leading are CYS Investments (CYS +3.1%), Annaly (NLY +1.7%), American Capital (AGNC +1.4%), (MTGE +1.5%), Invesco (IVR +1.8%), Anworth (ANH +1.3%), and AG Mortgage Investment (MITT +0.7%). The sector elephants - Annaly and American Capital Agency - are head 6% and 8% YTD, respectively.
- With the big drop in yields at the long end, how long will it be before investors stop fretting about declines in book value and shift to concern over narrowing spreads!
- Related ETFs: MORT, MORL
Mon, Jan. 13, 3:08 PM
- What might pull the mREIT sector out of its brutal slump? A slide in the broad equity market for one. An out of nowhere 1%-plus dive in the major averages is being felt in the bond market, where the 10-year yield is off another 3 basis points to 2.83%, and mortgage REITs (REM +0.4%) - whose book values have been savaged by the big jump in interest rates since last spring - are responding.
- Annaly (NLY +1.2%), American Capital (AGNC +1.4%), (MTGE +1.1%), Two Harbors (TWO +1.4%), CYS (CYS +1.9%), Western Asset (WMC +1.5%), AG Mortgage (MITT +1.1%), and Ellington Residential (EARN +0.8%) are leading. This just in: Sector giants American Capital Agency and Annaly are ahead 6% and 4% YTD, respectively.
- The iShares 20+ Year Treasury Bond ETF (TLT +0.6%) is up 3.2% for the year.
Fri, Jan. 10, 11:18 AM
- It's a big dip in interest rates today (the 10-year yield off 8 bps to 2.88%), but buyers are doing little more than tiptoeing back into beaten-down mortgage REITs.
- Leading are Annaly (NLY +1.3%) and American Capital (AGNC +1.4%), (MTGE +1.1%), and Armour (ARR +0.7%), CYS Investments (CYS +1.2%), and Invesco (IVR +1.1%) are also posting decent gains. All are quietly up in the area of 5-10% off of their 52-week lows set late last year.
- Related ETFs: REM, MORT, MORL
Dec. 10, 2013, 11:12 AM
- The mREIT sector (REM +1.2%) is up for a 2nd consecutive day, with Hatteras Financial's (HTS +1.5%) 9% dividend cut overnight not hurting the stock and suggesting maybe a lot of bad news has been priced in. Core income in Q3 was $0.44 per share and the new payout is $0.50.
- Another adjustable-rate mortgage player, CYS Investments (CYS +2.4%) is also ahead, as is Capstead Mortgage (CMO +0.9%). Others: Annaly (NLY +1.5%), American Capital (AGNC +1.7%), Invesco (IVR +2.4%), Western Asset (WMC +1.3%).
- Related ETFs: MORT, MORL
Dec. 6, 2013, 4:23 PM
- CYS Investments, Inc. (CYS) declares $0.32/share quarterly dividend, 5.88% decrease from prior dividend of $0.34.
- Forward yield 17.20%
- Payable Dec. 27; for shareholders of record Dec. 17; ex-div Dec. 13.
Dec. 6, 2013, 11:42 AM
- There's a bit of green spreading across the mREIT sector this morning as Treasurys reverse an early plunge following the strong jobs report - the 10-year yield is now off 3 basis points to 2.85% after climbing to 2.93% just after the 8:30 ET release.
- However, there's no relief for sector leaders Annaly (NLY -1%) and American Capital Agency (AGNC -1.5%), both of which continue to reel following Goldman's Sell recommendation yesterday - each have carved out new 52-week lows this morning. There may be plenty of players in the mREIT sector, but for the institutional big boys who have the Goldman report on their desks, there's just NLY and AGNC. Others in the red include: Armour (ARR -0.7%) and CYS Investments (CYS -1.1%).
- Posting gains: Chimera (CIM +0.8%), Invesco (IVR +0.2%), Hatteras (HTS +0.2%), Dynex (DX +0.7%), New York Mortgage (NYMT +0.3%), Apollo Residential (AMTG +0.7%), Javelin (JMI +1.1%), AG Mortgage Investment (MITT +2.3%).
- Related ETFs: REM, MORT, MORL.
Dec. 5, 2013, 1:17 PM
- A check of the mortgage REITs following Goldman's interestingly-timed initiation of Annaly (NLY -1.6%) and American Capital Mortgage (AGNC -1.1%) with Sells finds the sector (REM -0.8%) again underperforming the broad market.
- To review: Annaly is off about 40% in 8 months and American Capital is off about 42% in 7 months. Yes, higher interest rates have delivered a hit to their portfolios (which tend to be longish in duration), but investor distaste for the names also has both trading at roughly 20% discounts to their book values.
- So is the call late? Maybe. On the other hand, one well-known hedge funder defines a 50% loss as holding a stock that goes from being down 80% to being down 90%.
- Other names of interest: CYS Investments (CYS -0.4%), Western Asset (WMC -1%).
- Related ETFs: MORT, MORL
Dec. 2, 2013, 3:48 PM
- There's no mercy for the mREIT sector (REM -1.6%) as this morning's strong economic data sends the 10-year Treasury yield five basis points higher to 2.80%. Among the new 52-week lows today are sector giants Annaly (NLY -1.6%) and American Capital Agency (AGNC -1.8%).
- Also down sharply are Armour (ARR -2.4%), CYS Investments (CYS -2.4%), Dynex (DX -2.5%), American Capital Mortgage (MTGE -2.8%), AG Mortgage (MITT -2.4%), and Arlington Asset (AI -3.1%).
- Management matters, and investors have clearly lost some faith in the leadership of Annaly and American Capital - both of which trade at more than 20% discounts to book value. The newest favorite is that of Ellington Financial (EFC), where management has mostly been able to preserve book value this year. Company structure may have helped too - Ellington is a partnership, not a REIT and has somewhat more flexibility with its portfolio. The stock trades at just a 6% discount to October 31 reported book.
- ETFs: MORT, MORL
Nov. 26, 2013, 1:54 PM
- At what point do you just liquidate the portfolio? Habits die hard and traders used to hitting the sell button on the mREITs (REM -0.5%) are doing so again today even as interest rates slide a bit.
- Hitting another multi-year low today, Annaly (NLY -1.3%) - with a portfolio of very liquid assets heavily hedged against rising rates - is now selling for 20% less than September 30's reported book value.
- American Capital Agency (AGNC -0.8%) - with an equally liquid hedged portfolio - is also at about a 20% discount. Previous: CIO Kain promises to continue buybacks at this discounted level.
- Other agency players: Hatteras (HTS -1%), CYS (CYS -1.4%), Capstead (CMO -1%).
- Non-agency mREITs are slipping as well - even as Case-Shiller reports continued solid gains in home prices (which should boost portfolio values). Two Harbors (TWO -1.5%), MFA (MFA -1.4%), Western Asset (WMC -1.1%).
- ETFs: MORT, MORL
Nov. 22, 2013, 3:11 PM
- A nice backup in rates (the 10-year Treasury yield is off 4 bps to 2.75%) is of no help to the mortgage REITs (REM -0.3%), with sector kingpins Annaly (NLY -1.4%) and American Capital Agency (AGNC -1.2%) both hunkered down (NLY earnings call, AGNC earnings call) for the Fed taper, and both hitting 52-week lows today.
- Earlier this week, AGNC and MTGE CIO Gary Kain took his case all the way to Asia at the Citi financial services conference in Hong Kong (transcript). Yes, book value has been hit by higher rates, but also by how much the market is willing to pay for it. Whereas AGNC traded at an average of 110%-120% of book over the past 4-5 years, it's now at sub-90%.
- Discounts can last for awhile, he admits, but also reminds this isn't some opaque bank balance sheet, but instead an easily valued, highly liquid portfolio of assets trading at $0.85-$0.90 on the dollar. As long as it persists, American Capital will continue selling MBS for $1 and buying back stock at a discount.
- Previous: Kain makes a similar case
- Related ETFs: MORT, MORL
- Other sector stocks: Armour (ARR), Two Harbors (TWO -0.8%), CYS (CYS +0.1%), AG Mortgage (MITT -0.5%)
Nov. 11, 2013, 4:28 PM
- After Q2's shock, earnings maximization turned to book value preservation, says Nomura's Bill Carcache, but the market isn't rewarding management teams for this at the moment. "We have no confidence getting back in now in hopes that shares will begin their climb back toward book value ... 30-year MBS is not an asset class we want to own ahead of [tapering]."
- Hedge books may offer some protection, he says, but at quarter-end American Capital Agency (AGNC -1.8%), Annaly (NLY -2.3%), and CYS Investments (CYS -0.5%) held 43%, 80%, and 42% of their portfolios in 30-year MBS, respectively.
- American Capital is of particular interest given the "management premium" its CIO Gary Kain has enjoyed. "This quarter's review made it clear to us that traditional active managers have no edge and are holding back to see how the mortgage market reacts to Fed tapering." Ouch.
- Given the above, Nomura thinks a 15% discount to book value is entirely appropriate for the agency players and lowers its price target accordingly on AGNC and NLY. CYS has its price target nudged higher as it's already below 85% of book.
- Earlier today: Annaly de-levered and heavily hedged.
- Previous: AGNC's Kain hunkers down.
- Previous: CYS's Kevin Grant is perhaps a bit more aggressive.
- Relevant ETFs: REM, MORT, MORL.
Nov. 8, 2013, 9:51 AM
- Sharply higher interest rates has a number of mREITs (REM -2.4%) hitting new 52-week lows. Most of the stocks were already on the defensive over the past few sessions following near-universally disappointing Q3 results.
- Annaly (NLY -3.3%), American Capital (AGNC -2.9%), (MTGE -2.5%), Armour (ARR -3.7%), Invesco (IVR -3%), CYS Investments (CYS -5.3%), Hatteras (HTS -3%).
- Other related ETFs: MORT, MORL.
- Earlier: Big beat on jobs number sends Treasury prices south.
Oct. 29, 2013, 9:20 AM
- The first post-earnings downgrade for American Capital Agency (AGNC) comes from BAML, which removes its Buy rating. The quick take from the company's results (reported last night) shows CIO Gary Kain lightening up the portfolio and shortening duration just as the bond market was set to reverse course and move sharply higher. Today's 11 ET conference call should prove a worthy listen. AGNC -4.7% premarket.
- Armour Residential results show pretty much the same thing, with the book dropping to $16.7B from $22.6B a quarter earlier. ARR -4.1%.
- Other agency players premarket: Annaly (NLY) -1.9%, CYS Investments (CYS) -0.8%.
- Kain's non-agency vehicle: American Capital Mortgage (MTGE) -4.3%.
- ETFs: REM -0.6%. Also: MORT, MORL.
Oct. 25, 2013, 8:02 AM
- CYS Investments (CYS) looks to continue a nice post-earnings run after Bank of America removes its Sell rating on the stock and boosts the price target to $8.50.
- The company last week reported September 30 net asset value of $10.10 per share and this is the 2nd upgrade since.
- Q3 results, earnings call report.
- Shares +0.35% premarket to $8.71.
Oct. 22, 2013, 12:50 PM
- Throwing a small party in wake of the slow jobs number and resultant tumble in interest rates is the mREIT sector (REM +1.5%). The stocks were mercilessly punished all late spring and summer as interest rates rose, but have regained their footing since about September. The 10-year Treasury yield is at a 3-month low of 2.53%.
- Sector giants American Capital (AGNC +2%) and Annaly (NLY +1.5%) are now up about 15% from their 52-week lows set a couple of months ago.
- Sector fans will recall the stocks getting hit late in 2012 over fears rates - rate spreads, actually - were too low for the companies to earn any return on. With the taper off the table, will those worries return? Tough business.
- Other big movers today: Invesco (IVR +2.6%), Hatteras (HTS +2.9%), CYS (CYS +2.8%), Anworth (ANH +4.7%), New York Mortgage (NYMT +1.5%), Western Asset (WMC +1.1%).
- Other ETFs: MORT, MORL.
CYS vs. ETF Alternatives
Company Description
CYS Investments Inc is a specialty finance company that invests on a leveraged basis in residential mortgage pass-through securities for achieving consistent risk-adjusted investment income.
Sector: Financial
Industry: REIT - Diversified
Country: United States
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SPORTS: M-A, Woodside victorious Friday
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- Torrington football beats Crosby, 75-57, in one of highest-scoring games ever
- UConn hockey upsets No. 11 Vermont, 2-1, in Hartford
- An ordinary day marked an eventful occasion at the Yale Bowl
- Ryan Boatright scores 20 as UConn men outlast Dayton, 75-64, in Puerto Rico
- Report: Legendary West Haven head coach Ed McCarthy may not retire after all
- National Lacrosse League's New England Black Wolves show off new jerseys
Greatest Athletes in CT History: Stamford
- Updated: May 3, 2013
AP Photo
As part of a new series recognizing the greatest athletes in Connecticut history, SportzEdge.com is taking a comprehensive look at each town in the state and trying to decide whose athletic brilliance shone brightest.
Last week, we took a look at the Greatest Athlete in the history of Waterbury.
Today, we are looking at the greatest athletes in Stamford history. Hall of Fame defensive end Andy Robustelli tops our list. His name still resonates at the University of Bridgeport and with the New York Giants, where he won an NFL championship in 1956.
1. Andy Robustelli, NFL.
A graduate of tiny Arnold College in Milford (now part of the University of Bridgeport), the Stamford native spent 13 years in the NFL with the L.A. Rams and New York Giants. He was a seven-time Pro Bowl selection, and even won the Bert Bell Award as the NFL's Player of the Year in 1962. Robustelli won championships with the Rams (1951) and Giants ('56) and was inducted into the Pro Football of Fame in 1971. He was honored with the Walter Camp Man of the Year Award in 1988 for his contribution to the community.
2. Chris Dudley, NBA.
The Yale graduate and diabetes survivor played 16 years in the NBA with the Cleveland Cavaliers, New Jersey Nets, Portland Trail Blazers and New York Knicks. The 7-footer served as Patrick Ewing's backup and played big minutes in the 1999 NBA Finals. Dudley is memorable for his charitable efforts off of the court, using his self-named foundation to raise money to help kids living with diabetes. He's also notable for being an incredibly bad free throw shooter, finishing six whole seasons shooting less than 40 percent from the stripe.
3. Bobby Valentine, MLB.
The mercurial manager was once a star-crossed shortstop with the L.A. Dodgers, hitting .260 over nine injury-plagued years in the major leagues from 1969-79. The Stamford native and Rippowam High School graduate managed the New York Mets to the World Series in 2000, and led Japan's Chiba Lotte Marines to a championship in 2005. After a failed stint with the Red Sox last season, Valentine is back in Connecticut, working as the Athletic Director at Sacred Heart University in Bridgeport.
HONORABLE MENTIONS: Big league pitcher Jared Hughes has spent the past three seasons with the Pittsburgh Pirates and has pitched to a 3.23 ERA and 73 strikeouts in 91 relief appearances. Hughes grew up in California, but he was born in Stamford. John Scalzi also played one season in the majors with the Boston Braves in 1931.


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[Yet Another] Jillian Michael's Review
I'm a glutton for punishment. So when I saw a 2 pack of Jillian Michael's DVD's at target for just $10, I couldn't say no. I like Jillian's dvds because they're tough, but fast. Most of them are 45 minutes at the most, so they're perfect when I need … [Continue reading]
Peanut Butter Heady Goo Balls
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What I Ate [on a Budget] Wednesday
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Spreadable Peanut Butter Cup Filling
I was planning on posting an oatmeal muffin recipe today. But let's just say, the recipe testing didn't go as planned, and the muffins ended up tasting the chewy cardboard. Fail. But that's part of the trial-and-error process, no? Luckily, I didn't … [Continue reading]
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Remember the time I posted that recipe with 1,489 ingredients, and 19 steps, which basically took all day to actually do? Yeah, me either. If you've read my blog for more than a week, then you know this is not the place to come for … [Continue reading]
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I don't normally post on Thursdays, but this is being posted by popular demand. I was tweeting yesterday about my accidentally see through dress. Yeah. Oops. This is what I saw in the mirror before leaving the house: But that's not what you see … [Continue reading]
What I Was [Convinced] to Eat Wednesday
If you follow me on twitter, then maybe you saw my tweet about this. (What? You don't follow me on twitter? Really? Then click here and do it.) My dinner Monday night was actually kind of funny. After a 3 hour Monk marathon on Netflix, the … [Continue reading]
Product Reviews from Lolihop!
So the weekend literally flew by. I don't think I opened my computer at all. That's how busy it was. I actually have lots from the weekend I want to blog about, but I haven't had time to write up a post. So details to come. But for now, I have … [Continue reading]


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The Dewallen Splatter Flag Tee in Americana
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The Obey Dewallen Splatter Flag Tee in Americana
Rebel against basic style with the Dewallen Splatter Flag Tee from Obey clothing. This crewneck features an Americana style tie dye colorway, and is lightweight to keep you cool on those hot summer days.
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- 100% cotton
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Riccardo is wearing a size Medium.
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Photos and Description of this 1 bedroom holiday home in Bergen City - Ons Buiten
Holiday home, 1 Bedroom, 1 Bathroom, (Sleeps 2)
Spacious detached cottage, built in 1925 in the architectural period of the "Amsterdam School". Located within walking distance of the tourist center of the municipality of Bergen. Forest, beach and the most beautiful dunes of Europe.
Classification: Ground floor: (Hall, Livingroom(TV, fireplace, DVD player, CD player), Dining room(bar), Open plan kitchen(oven, dishwasher, fridge freezer), WC)
On 1st floor: (Bedroom(Double bed, Cot), Bathroom(shower, washbasin, toilet), Landing(tumble dryer, washing machine), balcony)
courtyard, garden(private), parking
These costs are charged on site. They are not included in the rental price.:
Deposit; € 250 (On arrival, you must pay the security deposit in cash)
Cleaning; Mandatory: € 50
Pets; Not allowed
Bed linen; Possible to rent per packet, € 8,95 p.p./Stay
Bath towels; Bring your own
Kitchen linen; Bring your own
Electricity; Included
Gas/Oil; Apr - Sep: Included; Oct - Mar: € 10/night
Wifi; Free
Tourist tax; Mandatory, € 1,45 /person/night
- Suitability:
- non smoking only
- pets not allowed


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Items Tagged with "Heart Health"
Hot Tubs are for More Than Just Relaxing: Enjoy the Health Benefits for Many Medical ConditionsWhen we think of hot tubs we think of a splurge of relaxation—a place where we can kick back our feet, warm our body, and drink a glass of champagne. But do you realize that they also have amazing health benefits?The heated water in hot tubs and their massaging bubbly waves can help people wit Read More...
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It was my wife's Birthday this weekend and I wanted to take her some place special. I'm so glad I came here! We have had an amazing stay. The staff members were so genuine and kind, the room was great, and the food beats most top tier restaurants. We also did the "wine snob" class and we absolutely loved it! We truly learned so much and had the opportunity to drink, not try , multiple wines! As we go back home to Columbus, we will definitely be spreading the word about the Hideaway Country Inn. I can honestly say that we will be back. B&B - Columbus, Ohio " "


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With nearly 80 musicians playing, Sidepony Express Music Festival in Bisbee promises to be one wild weekend. From Friday, November 14, to Sunday, November 16, folks from as far as Los Angeles, North Carolina, New Mexico, El Paso, Nashville, and Portland will make it to the southeastern Arizona minin ... More >>
Give a little taste of a great product and people are naturally going to want more. That's the solid logic of drug dealers, soft pretzel peddlers at the mall and Sun Ghost. Failed Kickstarter campaigns be damned: The Valley pop rockers took a new approach to crowd sourcing the funding for their ne ... More >>
Clockwise from top left: DJ Dana, Courtney Marie Andrews, Sun Ghost, Source Victoria Welcome to the latest installment of our weekly feature, Sound Off, in which Jason P. Woodbury is joined by a different guest each week to listen to and discuss three tracks from local Phoenix artists. If yo ... More >>
This week's issue is a weird one. In our feature, Danny Torgersen and Trevor Denton of Captain Squeegee and Sun Ghost discuss the Rock the R3volution tour, a musical celebration of Ron Paul. Yeah -- as strange as that is. In our Shrapnel section, Chris Piel examines the potentially long-lasting ... More >>
We've done a lot of coverage on the Rock the R3volution tour, from its announcement to almost inevitable collapse. The confluence of music and politics has always been interesting to me. Political art can be cringe-worthy ("boot up 'yer ass," anyone) or undeniably beautiful ("a change is gonna co ... More >>
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MIAMI — Circumstance got in the way. Because few, otherwise, were as deserving to stay.
What Mike Miller did for the Miami Heat on June 21, 2012 arguably stands as the most dramatic performance in the franchise's 26 seasons, up there with anything Dwyane Wade, LeBron James, Chris Bosh, Shaquille O'Neal, Alonzo Mourning or Tim Hardaway have accomplished.


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Federal agencies are not as skilled in engaging the public and encouraging participation as are professionals at private-sector organizations, according to an industry report.
Agencies could improve by applying industry best practices and standards to achieve high-quality public participation, the report states. It was released Aug. 22 by the IBM Center for the Business of Government and AmericaSpeaks, a nonprofit organization that promotes town hall meetings on public policy issues.
The report was written by Carolyn Lukensmeyer and David Stern, AmericaSpeaks' president and director of online engagement, respectively, and Joseph Goldman, director of Omidyar Network.
The authors gave high marks to the Environmental Protection Agency, Health and Human Services Department, NASA and Transportation Department for superior levels of public engagement.
Related stories:
Challenge.gov seeks to expand public's engagement
Obama creates public engagement office
But overall, most agencies are falling short, the report states. After
reviewing 29 agencies' open-government plans with regard to public
participation, the authors concluded that most of the federal plans did
not meet the standards for high-quality participation used by industry.
The authors view the goals of public participation and engagement as
underdeveloped aspects of the open-government plans, which primarily
focus on transparency.
The plans were vague about what agencies would do to foster participation and engagement, the report states.
"The low level of detail offered in most agency open-government plans
makes it very difficult to know what type of participation is being
described and what level of quality will be achieved," the authors
The private sector offers a number of best practices that could be used
to achieve high-quality public participation, the report states.
Specifically, agencies should:
About the Author
Alice Lipowicz is a staff writer covering government 2.0, homeland security and other IT policies for Federal Computer Week.
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GSA's administrator talks with FCW about short-term hiring, long-term planning and Robert Frost.
Without a future vision and an appetite for risk, reforms lead down a rabbit hole. There is a better way.
VA's top tech official says he is balancing risks while trying to keep the department's online services open for business.
After five years on the job, the founding director of the Office of Government Information Services believes that a deeper understanding and acceptance of FOIA is seeping into the federal government.
The September attack, made public Nov. 10, potentially puts customer and employee personal information at risk, including addresses, Social Security numbers and emails.
The General Services Administration's Matthew Goodrich predicts more agency-driven authorizations and previews a new two-year road map.
Archie Mackie became product director of enterprise computing at the Army PEO EIS in June. In a Nov. 7 interview with FCW, he explained why the Army is cautious but hopeful in its adoption of the cloud.
While IT procurement and design are already quite centralized under the Office of Information and Technology, sources tell FCW that telemedicine IT and app development at the Veterans Health Administration will be rolled up under the OI&T as well.
Steve Kelman argues that the best place to improve federal procurements is at the beginning.
The recommendations set forth in the report are now available in StratML format at http://xml.gov/stratml/drybridge/index.htm#AS or, more specifically, http://xml.gov/stratml/carmel/APPOGEwStyle.xml
Findings One and Four are closely related to the purposes of the StratML standard: http://xml.gov/stratml/index.htm#DefinitionPurposes
8609 Westwood Center Drive, Suite 500Vienna, VA 22182-2215 703-876-5100
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Oklahoma > Enid Yellow Pages > Arts and Entertainment > Entertainment > Entertainers Enid
Philip & Henry USA Inc In Oklahoma City
Dates Are Disappearing! We Provide Great Magic Shows. Call Now!
Bagpiper & Guitarist-Michael Lancaster
(303) 765-1245
Colorado based bagpiper and guitarist, Michael Lancaster is a very versatile and highly sought af... More>
Devin Henderson Magic Entertainment
(913) 499-6602
Performing for audiences in the Midwest and in major cities across the United States, including K... More>
Gigliotti's Magical Entertainment & Party Rentals
(800) 933-2346
Magical Entertainment from the past to present has captured the hearts of millions such magical... More>
Broad Comedy
(406) 522-7623
Out Da Box Film & Music Productions
(678) 492-2301
We are a Locally owned and operated Film and Music Production Company in the Atlanta GA. area and... More>
Bagpiper & Guitarist-Michael Lancaster
(303) 503-1100
Colorado based bagpiper and guitarist, Michael Lancaster is a very versatile and highly sought af... More>
(515) 256-0999
My name is Ray Thompson, book my hypnosis stage show to liven up your conference, convention, or ... More>
Talent Productions
(480) 947-3388
Talent Productions provides event planning, keynote speakers, comedians, variety entertainers, mu... More>
Audio Meltdown
(580) 541-2330
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Talley, Michele
1720 2nd Ave. S. Birmingham, AL 35294-1210
Other information
Education MSN University of Alabama at Birmingham BSN University of Alabama Biography Prior to appointment as a faculty instructor, Mrs. Talley was employed as a CRNP with a group of cardiothoracic surgeons. The past year she spent developing glycemic control protocols for an inpatient setting and continues to work at this facility as needed. Mrs. Talley is currently pursuing her board certification in advanced diabetes management. Research/Clinical Interest
- Hyperglycemia
- Diabetes mellitus
- Cardiothoracic surgery
Publications/Presentations "Inpatient Hyperglycemia" presentation at Druid City Hospital in Tuscaloosa, AL, 2008 "Inpatient Hyperglycemia" presentation for the Alumni of St. Vincent's School of Nursing, 2008 Honors/or Memberships Member of Sigma Theta Tau, Nu Chapter American Association of Diabetic Educators Care Associate Member of American College of Cardiology American Academy of Nurse Practitioners Central Alabama Association of Nurse Practitioners


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Isaac Clark / Dead Space
by Maxim Nikitin
Phone Cases
Protect your iPhone with a one-piece, impact resistant, flexible plastic hard case featuring an extremely slim profile. Simply snap the case onto your iPhone for solid protection and direct access to all device features.
sci-fi horror video game
- 22Promote


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Regular Office Hours
We routinely close for staff training on the second Wednesday of every month from 1:00 p.m. to 3:00 p.m. If you need assistance during this time or have any questions, please call in advance! We would be happy to help you.
In an Emergency
In case of emergency, please call us immediately at 781-641-3673.
If it is after hours, check with one of these 24-hour emergency clinics:
Massachusetts Veterinary Referral Hospital
20 Cabot Road
Woburn, MA
Angell Animal Medical Center
350 South Huntington Avenue
Boston, MA
VCA South Shore Animal Hospital
595 Columbian Street
Weymouth, MA
Veterinary Emergency and Specialty Center of New England
180 Bear Hill Road
Waltham, MA
Surgery Drop Off Hours
When your cat is scheduled for surgery, an ultrasound, or an echocardiogram, please bring your pet in between 8:00 a.m. and 8:30 a.m. on the designated day. Your cat should not receive food after midnight the night before so be sure to pick up the dish after supper. Thank you!


text: On December 4, 2013, at 3:40 am, an unknown male approached the Loco Pez Bar located at 2401 East Norris Street in Fishtown while three complainants were outside forcing them inside the bar at gunpoint. Once inside the suspect forced the complainant's to place their cell phones and wallets on a table demanded money from the employees when one of the employees gave the suspect an undetermined amount of money. After taking the money from the bar and $40 from one of the complainant's the suspect fled in an unknown direction.


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Town Square
Welcome to Town Square!
Original post made by Richard Hine, editor of The Almanac, on Oct 9, 2006
For example, what do you think of the new Palermo restaurant in Menlo Center? Here's a story Almanac food writer Jane Knoerle wrote in February: Web Link
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Grab a Bowl of Heaven soon in Mountain View
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Investing Advice Inspired by Jack Bogle
madbrain wrote:Anon1234 wrote:What are you using the number for?
I believe I answered that in my original post.
dhodson wrote:Unfortunately, agents will try to convince folks that your experience is atypical or that a policy can be crafted such that you will be happy.
spectec wrote:One question came to my mind. If this signing bonus was considered earned before you moved and began working at the new location, it might actually be taxable In the prior state.


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The Top 10 In Action Sports
01From Cycling The World To Rowing The Arctic... We Talk Adventure With Mark Beaumont
02Four Mini Adventures That Are Closer Than You Know
03This Odyssey Vancouver Edit Will Give You The BMX Fix You Desperately Need
04This Stunning Footage Will Make You Want To See The Northern Lights
05Did Dan Atherton And Red Bull Just Create The Toughest Downhill Track Ever?
065 Action Sports You Should Try On Your Gap Year
07The Drone Footage Of This Abandoned City Will Leave You Absolutely Stunned
08Want To Be A Better Skater? These Scientific Secrets Will Help You On Your Way
09This Hollywood Stuntman Just Dropped An Air Bag Edit That's Flippin' Mad
10This Ken Block Gymkhana Parody Is The Best Thing We've Seen In Weeks
Trek Remedy 27.5
A Mountain Biking video by trek - 1,108 views
See the Remedy models at http://www.trekbikes.com/remedy.
Rene Wildhaber and Jeremy Horgan-Kobelski (JHK) found themselves in British Columbia with some time before an enduro. They contacted a float plane, rented a cabin in the Chilcotins and grabbed their Trek Remedy 27.5s. They spent a few days going on some all-day backcountry rides on the 140mm travel trail bike, weaving up the backsides of mountains before charging down.
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Free French Film, "Avenue Montaigne"
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By Maria Murzyn
The River Forest Library is proud to host the award-winning film, "Avenue Montaigne" as part of its' Paris-themed screenings. The film will be shown on Sunday, May 1 at 2pm at the library, 735 Lathrop and is Free. Watch the attached clip to sample this wonderful film. More info at 708-366-5205 or at http://www.riverforestlibrary.org.
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A project of People For the American Way dedicated to monitoring and exposing the activities of the right-wing movement. Learn More >
Phyllis Schlafly
Phyllis Schlafly Top Posts
Five Of The Craziest Conservative Reactions To Obama's Immigration Action: Impeachment, Race War & Rebellion
In this special edition of Paranoia-Rama, we look at five of the most incendiary and unhinged responses from our friends on the Radical Right to President Obama's announcement that he would grant temporary deportation relief to some unauthorized immigrants and his speech last night laying out his plan. MORE >
Phyllis Schlafly Posts Archive
SUBMITTED BY: Brian Tashman, Monday 12/23/2013, 3:20pm
While the vast majority of Americans, including Republicans, back a comprehensive immigration reform plan that includes a pathway to citizenship, the Nativist movement is still trying to scare voters and elected officials into thinking that attempts to fix America's broken system will actually destroy the country…and all of civilization. Here's a look at some of 2013's worst xenophobic leaders, including our choice for "Nativist of the Year": 8. William Gheen Americans For Legal Immigration PAC (ALIPAC) leader William Gheen hasn't changed his tune... MORE >
SUBMITTED BY: Kyle Mantyla, Thursday 12/19/2013, 5:32pm
Ken Hutcherson, best known around here for being a vehemently anti-gay activist, has died after a long battle with cancer. If you are going to send out an email blasting a member of Congress, at least make sure you are attacking the right one. FRC prays against ENDA: "While the Democratic-controlled Senate passed the bill, House Speaker John Boehner (R-Ohio) has said the House will not take it up. Pray for the activist agenda to end here and for future Congresses to turn back the clock on the legalization and celebration of what the Bible declares to be sinful and... MORE >
SUBMITTED BY: Brian Tashman, Thursday 12/05/2013, 5:45pm
The news today of Nelson Mandela's passing is also time to reflect on the complicated relationship between Mandela and his anti-apartheid African National Congress (ANC) with the US, which did not always support the anti-apartheid struggle. In fact, American conservatives lobbied the federal government in the 1980s to withhold support from the anti-apartheid movement. President Reagan added the ANC to the US terrorism watch list, a designation not removed until 2008, and unsuccessfully vetoed sanctions against the apartheid regime. Many Republican lawmakers did break with the Reagan... MORE >
Schlafly & Solomon: Liberals Will Take Kids From Conservatives, Give Them To Gays Who Will Abuse Them
SUBMITTED BY: Brian Tashman, Wednesday 12/04/2013, 4:45pm
Last night, Stan Solomon hosted Eagle Forum head Phyllis Schlafly to discuss his latest conspiracy theory that liberals intend to take kids away from conservatives and give them to gay people, some of whom will inevitably molest them. Why haven't you and I heard of this plot? Because the media is covering it up, of course! Schlafly also criticized President Obama for "insulting" Americans when he "omitted" the word "God" from his recent recitation of the Gettysburg Address. Of course, her claim is completely false: Obama was reading the first draft... MORE >
SUBMITTED BY: Miranda Blue, Tuesday 11/19/2013, 12:39pm
Last month, the International Olympic Committee announced that it would restore the sport of wresting to the docket for the Summer Olympics after a public outcry over its removal. Among those pleased by the sport's return to the Olympics is Phyllis Schlafly, who, of course, blames "the feminists" for the sport's original cancellation. "The opposition to wrestling was probably coming from the feminists who do not excel in the sport of wrestling, and who dislike anything that is truly masculine, as wrestling certainly is," Schlafly said in her radio... MORE >
SUBMITTED BY: Brian Tashman, Thursday 11/14/2013, 2:25pm
Phyllis Schlafly appeared on Crosstalk last week, where she went through her usual argument about why Latino immigrants don't make good Americans because they are less likely to vote Republican and hold conservative political views. She told host Jim Schneider that immigrants used to "be proud to be an American" and "became good people," unlike "the people who are coming in now" who "don't agree with the fundamentals of America." Schlafly also warned that immigration authorities are allowing Muslim immigrants to practice polygamy... MORE >
SUBMITTED BY: Brian Tashman, Tuesday 11/05/2013, 12:10pm
Conservative activists regularly claim that they are the real victims of bigotry and compare themselves to persecuted people throughout history, frequently citing bogus cases to show proof of their pain. As Kyle noted earlier today, "One thing that you can count on from the Religious Right is that once a talking point has been established, it will be repeated endlessly even after it has been proven to be demonstrably false." Take today's Phyllis Schlafly column for example, where she warns that the First Amendment is under attack in public schools: Some public-school... MORE >
SUBMITTED BY: Miranda, Monday 11/04/2013, 1:02pm
Last December, former Republican senator and presidential candidate Bob Dole took to the Senate floor in a wheelchair to urge his former colleagues to ratify the Convention on the Rights of Persons With Disabilities (CRPD), a United Nations treaty that would encourage countries around the world to emulate the United States' protections for the rights of the disabled. The treaty fell six votes short of the 2/3 majority it needed for passage, thanks to an intense lobbying effort by Religious Right groups that warned – against all evidence – that the treaty would threaten U.S... MORE >
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Andrew Harrison
Andrew Harrison is Technical Editor at PC Advisor, responsible for writing and editing product reviews as well as overseeing the testing of PCs and laptops for the magazine's monthly charts section. When not at his office desk, Andrew can be found probing the latest tech in the IDG test lab, devising novel ways to evaluate products.
He has a broad interest and experience in computer technology from routers and networking to open-source, Macintosh and Windows systems. Prior to PC Advisor, Andrew worked in technical editing positions in specialist hi-fi and music publications.
Articles by Andrew Harrison
Windows 7: Haven't we seen this before?
Convicted monopolist Microsoft is back in the news for colluding with Intel to sell unsuitable chips for running Vista.
Cambridge Audio DacMagic review
Cambridge Audio's DacMagic is back – and this time it wants your USB
Chord Electronics Chordette Gem review
High-end audio specialist Chord Electronics has the world's first stereo Bluetooth audio adaptor
Corsair Voyager 64GB review
Hard on the heels of our review of the Corsair Voyager Mini, we have the company's latest USB memory stick, and also its largest, in every sense…
Corsair Flash Voyager Mini 4GB review
Incredibly small but still packing 4GB of storage – that's Corsair's cute little Flash Voyager Mini USB stick
Cyber E Sport Orbita review
The wireless Cyber E Sport Orbita is a perfectly round mouse that aligns itself with the help of the earth's magnetic field, just like a compass.
Samsung NC10 review
The MSI Wind U100 is arguably the pick of current netbooks, inspiring rebadged versions under such names as Advent and Medion. Samsung must have…
T-Mobile G1 review
To evaluate T-Mobile's new G1 wonderphone is inevitably a review of two halves: the handset hardware and its operating system software. (SEE ALSO:…
Novatech X50MV review
Novatech has aimed at producing a high-performance gaming system with its new Novatech X50MV laptop, a 15in-screen model fitted with the capable…
Palicomp Carbon TFT-22 review
The Palicomp Carbon TFT-22 is a desktop PC, with peripherals, that retails for less the £400.
Comments by Andrew Harrison
Sennheiser Momentum Black review: bloated bass-focused headphone
Thank you PVPSAAAAN for that accolade. I'm... humbled. Does the author of the most-biased-review-on-the-internet get an award to show for it? Even…
WD LiveWire review
Hi Lyndon It was confirmed as true that the WD LiveWire only has 10/100 ethernet ports. And Western Digital is not alone in putting in…
Google Android: freephone toll
Hi SamDe, care to elaborate on your comment? I'd welcome any feedback for factual inaccuracies I may inadvertently have made. Thanks, Andrew…
Google Android: freephone toll
Not necessarily – in our group test of 25 Android anti-malware apps, there were three products that identified 90% or more of the malware samples.…
iPad review
Hi Oliver, thanks for the post – I hadn't heard that story about iOS crashing more than Android. And a story I believe it to be, based on my own…
iPad review
Withholding tech? Care to expand? It doesn't need to match competitors; if they want to make a viable tablet then it's they that need to catch up…
Quiet PC Serenity Z68 Gamer Xtreme review
We have now heard back from Quiet PC, which informed us that the price of some sub-components had increased and these were automatically but…
Samsung Galaxy Nexus review
Hi Kieran Thanks for your comments! Choice is good, a point I certainly appreciate. And for powerful reasons of personal principle I can truly…
Palicomp Phoenix i5 Solar Flare review
Hi Andy The XFX components look about right as substitutes. But please get in touch with me directly so I can clarify some other points:…
Apple MacBook Pro 15in (Early 2011) review
Hello Revolutionay United Front No intention to be disingenuous about Thunderbolt here - the facts stated and my personal commentary on the new…


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November 28, 2014
MADISON, Wis. (AP) -- Madison police have arrested a man who allegedly beat a woman because he was upset with a Christmas gift she bought.
Police say the 23-year-old Madison man was arguing Sunday with a 30-year-old woman.
A police spokesman tells The Capital Times the man said the woman had been out shopping too long and had bought the wrong Christmas gift.
Officers were sent after getting reports of a man with a gun. When police arrived they saw a man running from the building. He jumped over a fence but was stopped by officers.
The police spokesman says people told officers the man allegedly battered the woman in a hallway of the apartment and that he was carrying a gun case.
Officers recovered cash, marijuana, ammunition and a 12-gauge shotgun.
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Photo : St. Claire of Assissi Parish Church, Sta. Clara, Sto. Tomas, Batangas
A picture of 'St. Claire of Assissi Parish Church, Sta. Clara, Sto. Tomas, Batangas', this photo is taken in the destination of San Juan in the province of Calabarzon in the country of Philippines. Click on the image below to see a high resolution version at the panaramio.com website. You can add your photo(s) to this gallery via the links below, or you can click here to see more photos of San Juan, Philippines. All photos are displayed according to Panaramio's Copyright Policies.
Photographer: cesarcambay [05 January 2009]
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