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Sorry I've been gone. Things are busy, busy, busy right now, and honestly nothing other than Sundance sales were happening much last week. Also, did I mention the busy? Because I was crazy with the busy. And I don't mean things like "watching great television like 'Community' all day" busy. I mean "Dear God, grant me the opportunity to pause this madness long enough to void my bowels" busy. I far...
entered on 01/31/11 at 10:45 PM | read more »
Black Swan
Director Darren Aronofsky's Black Swan is just your run-of-the-mill "girl haunted by doppelgangers while turning into a human/swan hybrid" ballet movie with elements of bisexual experimentation. In other words, writers Mark Heyman, Andres Heinz and John McLaughlin are a collective Dr. Frankenstein, standing over a creation that is part horror, part pure beauty. Firmly entrenched in...
entered on 01/29/11 at 04:32 AM | read more »
The King's Speech
Remarkably unremarkable and tonally mundane, director Tom Hooper's The King's Speech was seemingly genetically engineered by a mad scientist named Juan Tan-Oscar. Quasi-historical and wholly predictable, the film would have been dismissible as icky chum for suit-wearing Academy sharks were it not for Geoffrey Rush and Colin Firth. Their tête á têtes are more frosty diction than Frost/Nixon...
entered on 01/26/11 at 06:12 PM | read more »
No Strings Attached
Director Ivan Reitman is best known for ridiculous, male-dominated comedies like Ghostbusters and Stripes, but his latest, No Strings Attached, is like a romantic-comedy masterclass. Not that it's a masterpiece of the genre, but it so expertly strikes all the right nerves that it's still a little irresistible.
One drunken night and one impulsive morning are all it takes to bring former...
entered on 01/26/11 at 03:42 PM | read more »
entered on 01/26/11 at 03:36 PM | read more »
DVD Discovery: Animal Kingdom
Let's give it up for the ladies. Once the purview of mustachioed men with Italian last names, the "cops and crooks" movie genre has flung open the doors to the clubhouse. Last year gave us several films in the genre with strong female leads instead of damsel-in-distress love interests. Playing an Aussie-accented version of The Godmother in the under-appreciated Animal Kingdom, Jacki Weaver...
entered on 01/26/11 at 03:31 PM | read more »
Why would people see a movie this weekend? Don't they know they have to spend Friday night shopping for goodies for Sunday's Bears game, spend Saturday doing the necessary voodoo and sacrifices, and spend Sunday morning crying, breathing into a bag, and then trying not to barf as the Bears attempt to go to the Super Bowl? That's what everybody else is doing right? Well, apparently, that's not...
entered on 01/21/11 at 10:48 PM | read more »
Hunger Games: Mockingjay Part 1
Half of what promises to be an epic conclusion to a fabulous series.
A delirously fun satirical send up of artistic pretension.
"The Grapes of Wrath" in documentary form set in North Dakota.
If this was humanity's last hope, give up.
A condemnation of crime pornography with a chilling central character.
You kill his dog, he kills a million people. You've been warned.
The type of smart, ballsy satire that comes along all too rarely.
War is hell, but this movie is just hella slow.
The Burden of Actual Christianity
Most praise for writer/director Jesse Moss's documentary, The Overnighters, has rightly been focused on its Steinbeckian...
Preposterous, pseudointellectual, poorly constructed, clichéd, impenetrably masculine, goofy and possessed of an...
Yesterday, CNN showed reporters physically chasing a woman connected to the Ebola scare. Not too long ago, a Fox News...
John Wick killed three guys with a pencil.
John Wick is so good at killing, he had to bury his guns beneath a cement floor...
Movieha! Your favorite movie podcast
Movieha! Your favorite movie podcast
Movieha! Your favorite movie podcast


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Posted September 05, 2012 on AP on Fox
Miguel Cabrera hit a two-run homer in the first inning and Prince Fielder added a solo shot in the eighth to help the Detroit Tigers avoid a three-game sweep with a 7-1 victory Wednesday night over the Cleveland Indians. Detroit's Doug Fister (8-8) allowed a run and four hits in seven innings. He struck out six and walked one. Ubaldo Jimenez (9-15) gave up four runs and six hits in 7 1-3 innings. He was generally sharp after allowing Cabrera's 35th homer of the year, but Detroit tacked on five more runs in the eighth to break it open. The Tigers lost back-to-back 3-2 games to start this series but took the finale to remain a game behind the first-place Chicago White Sox in the AL Central. Fister has been on the disabled list twice this season and also missed a start Aug. 25 because of a groin problem. He's had Cleveland's number lately, though. In his last seven starts against the Indians, he's 5-1 with a 1.54 ERA. Detroit is hoping for another big September...
Original Story: http://msn.foxsports.com/mlb/story/Ti...
PLAYERS: Miguel Cabrera, Prince Fielder, Doug Fister, Ubaldo Jimenez, Justin Verlander, Max Scherzer, Austin Jackson, Michael Brantley, Andy Dirks, Jhonny Peralta, Joaquin Benoit, Ezequiel Carrera, Casey Kotchman, Shin-Soo Choo, Jason Donald, Jim Joyce, Armando Galarraga, Brennan Boesch
TEAMS: Detroit Tigers, Cleveland Indians, Chicago White Sox, Houston Astros
TEAMS: Detroit Tigers, Cleveland Indians, Chicago White Sox, Houston Astros
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subset: commoncrawl


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MyHealth gives you secure, anytime access to your health information.
- Message your clinic
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We are available to assist you whenever you need it. Give us a call at 650-498-3333 or firstname.lastname@example.com.
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Acute lymphoblastic leukemia (ALL) diagnosed within the first month of life is classified as congenital ALL and has a significantly worse outcome than ALL diagnosed in older children. This suggests that congenital ALL is a biologically different disease, and thus may be caused by a distinct set of mutations. To understand the somatic and germline mutations contributing to congenital ALL, the protein-coding regions in the genome were captured and whole-exome sequencing was employed for the identification of single-nucleotide variants and small insertion and deletions in the germlines as well as the primary tumors of four patients with congenital ALL.Exome sequencing was performed on Illumina GAIIx or HiSeq 2000 (Illumina, San Diego, California). Reads were aligned to the human reference genome and the Genome Analysis Toolkit was used for variant calling. An in-house developed Ensembl-based variant annotator was used to richly annotate each variant.There were 1-3 somatic, protein-damaging mutations per ALL, including a novel mutation in Sonic Hedgehog. Additionally, there were many germline mutations in genes known to be associated with cancer predisposition, as well as genes involved in DNA repair.This study is the first to comprehensively characterize the germline and somatic mutational profile of all protein-coding genes patients with congenital ALL. These findings identify potentially important therapeutic targets, as well as insight into possible cancer predisposition genes.
View details for DOI 10.1186/1471-2407-13-55
View details for Web of Science ID 000315027900001
View details for PubMedID 23379653


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books about: cheesecake
The Greatest Cheesecake Recipes: The Most Delicious Cheesecake Recipes In History
, 2014
Make Your Life Sweeter With Homemade Cheesecakes! Today only, get this Kindle book for $2.99. Regularly priced at $5.99. Read on your PC, Mac, smart phone, tablet or Kindle device. Cheesecakes are one of the world's most popular desserts…and rightly so. They are just so delicious and come in many different variants. Getting them from the bakeshop can be expensive, not to mention restrictive in the sense that you're limited to the ...
125 Best Cheesecake Recipes
George Geary
Robert Rose
, 2002
Is there anyone who doesn't relish the creamy delight of cheesecake? Most of us think that delicious cheesecake is only available in a restaurant or our favorite bakery. However, what if some of your concerns, such as it's too much work, too difficult and it requires too many ingredients, could be dispelled? The 125 Best Cheesecake Recipes contains dozens of delectable cheesecake recipes, each more luscious than the last. Explore ...
The Cheesecake Bible: Includes 200 Recipes
George Geary
Robert Rose
, 2008
The definitive book on luscious, decadent cheesecake by a master chef and baker. Almost everyone relishes the creamy delight of a well-crafted cheesecake. But isn't a really good one available only in a bakery or restaurant? George Geary proves that home-made can be better than bakery-made, with 200 delectable cheesecakes that can easily be made in the home kitchen. This decadent and delicious collection of prime cheesecake recipes ...
Cheesecake Recipes: The Ultimate Cheesecake Recipe Cookbook
, 2014
Cheesecake is, no doubt, one of the best desserts ever. It is so smooth and heavy, yet it is easy to swallow. But despite this, it could be quite difficult to make one. You must master, or at least be familiar with, the steps in order to make the perfect cheesecake. Remember, one wrong move could ruin your delightful cheesecake. But don't you worry because in this cookbook, we will elaborate the steps and include more tips in every recipe ...
Junior's Cheesecake Cookbook: 50 To-Die-For Recipes of New York-Style Cheesecake
Beth Allen
Alan Rosen
Taunton Press
, 2007
Baking quite possibly the best cheesecakes in the universe, Junior's Restaurant is a legend in its own right. Located in downtown Brooklyn, Times Square and Grand Central Station in New York, this home away from home has been wooing New Yorkers since it first opened its doors on Election Day, 1950. And now, finally, they are willing to offer up the recipes that have had Brooklynites double-parking on Flatbush Avenue for generations. Included are ...
Hannah Miles
Ryland Peters & Small
, 2013
Cheesecakes are one of the oldest desserts in existence, traceable back to ancient Greece, where they were served to the Olympic athletes. And it's no wonder they have been around so long! Simple to make and undeniably irresistible, Cheesecake celebrates this most beloved of desserts. A chapter on the Classics includes simple Baked Vanilla, Raspberry Ripple and Chocolate Chip cheesecakes. Whatever the time of year, Fruity cheesecakes are the ...
The 50 Best Cheesecakes in the World: The Winning Recipes from the Nationwide "Love that Cheesecake" Contest
Larry Zisman
Honey Zisman
St. Martin's Griffin
, 1993
If you're passionate about cheesecake, you'll love the gourmet and classic recipes assembled in this tempting book. Featured are the winning recipes from the Nationwide "Love That Cheesecake" Contest-50 of the richest, sweetest, creamiest, most delectable cheesecakes imaginable. Organized by pan size, the recipes include: key-lime cheesecake, marzipan-raspberry cheesecake, chocolate-malt cheesecake, hazelnut-heaven cheesecake, white-Christmas ...
Cheesecake Extraordinaire : More than 100 Sumptuous Recipes for the Ultimate Dessert
Mary Crownover
, 1994
Who can resist the rich, creamy, melt-in-your-mouth bliss of cheesecake? Cheesecake Extraordinaire presents 121 recipes for this indulgent yet easy-to-make treat. From luscious Chocolate Toffee Cheesecake to lighter-than-air Creamy Lemon Cheesecake, each recipe is sure to please even the most discriminating dessert lover.
Junior's Dessert Cookbook: 75 Recipes for Cheesecakes, Pies, Cookies, Cakes, and More
Beth Allen
Alan Rosen
Taunton Press
, 2011
What would life be without dessert? With this book, you'll never have to find out. Junior's Restaurants, the landmark chain with four locations on the East Coast, are nationally known for their award-winning cheesecakes. But Junior's has perfected other confections, too; here, more than 30 full-page, four-color photographs showcase 65 fabulous desserts. Authors Alan Rosen and Beth Allen present scaled-down kitchen-tested recipes so bakers can ...
Simply Delicious Italian Cakes & Cheesecake Recipes - (Delicious Collection of Italian Cakes and Cheescake ...
, 2013
Inside this book is a wonderful collection of simply delicious Italian cakes and cheesecakes recipes with easy to follow directions and PHOTOS! You will fall in love instantly! The Italian cakes are made using fresh fruit, nuts, or filled and frosted with a creamy filling. The Italian cheesecakes recipes are made with ricotta cheese, mascarpone cheese and cream cheese, which give them a creamy light texture. Impress your family and friends ...
The Cheesecake Recipe Book - Cheesecake recipes to amaze your guests!
, 2011
Cheesecake is one of those desserts that just about everyone likes, and there are as many versions of this classic dish as there are people who enjoy it. Whether baked on unbaked, biscuit or sponge base, fruit or chocolate topping, everyone has their favourites but they are all delicious! In this book, from best selling recipe author Judith Stone, you'll find a concise collection of fantastic cheesecake recipes, using a variety of ingredients ...
Effortless Gourmet Cheesecakes - Delicious Cheesecake Desserts and Recipes -101 Cheesecake Dessert Recipes: ...
, 2014
Mmmmm.....Cheesecakes! Really, not much more needs to be said. Quite possibly the best, most versatile and beloved dessert! Everyone loves cheesecake! Read on your PC, Mac, smart phone, tablet or Kindle device. Over 100 of the best cheesecake recipes with easy to understand, step by step directions. Make mouth watering desserts for your family and friends with this deliciously helpful recipe guide! Here Is A Preview Of What is ...
Cheesecake Recipes: 20 of the Most Classical and Decadent Cheesecake Recipes and More Than 40 Simple Tips for ...
Angelina Jarreau
CreateSpace Independent Publishing Platform
, 2012
***Amazon Best Seller in Cakes and Desserts Categories !!*** Cheesecake is one of those few desserts that has it all - rich, very tasty, high quality, great presentation options, and just plain elegance. It also does not require a baking degree from a culinary school to make to perfection! All you need are some basic tools, one of which is this little book! I have assembled the best tested cheesecake recipes with simple easy directions ...
Heavenly Cheesecakes - 30 Melt-in-Your-Mouth Cheesecake Recipes (Homemade Happiness Book 1)
Sheila Taylor, 2014
"Tried and true. These recipes are amazing!! I've never had a compilation of such tasty treats that are made with real ingredients." - Mrs. Bahr "I definitely want to try every recipe in this book! My mouth watered just reading the recipes. I love a good cheesecake!!!" - Ann "Sheila Taylor has a natural flare and passion for cooking, and is always perfecting recipes...I consider her a rising star, and am thrilled that she finally has ...
, 2013
This is a cookbook for all different types of cheesecakes!
How To Make Cheesecake:All your questions answered - anyone can create the most mouth watering cheesecake for ...
Sofia Johnson, 2012
In this kindle cheesecake cookbook I am going to show you how to easily create both chilled and baked cheesecakes. I used the cheesecake recipes in this book every day at my cafe much to the delight of my loyal customers I have made the step by step instructions very easy for you to follow. Advice is given on all weights and measurements and the specific temperatures for all types of ovens. The secret to making sure there are no ...
I Love Cheesecake
Mary Crownover
Taylor Trade Publishing
, 2005
Divinely decadent cheesecake is the perfect dessert, whether you're brining it to a party or entertaining friends at home. It's impressive and elegant, yet so easy to make. Mary Crownover's methods prevent cracking, splitting, and falling, giving you the perfect cheesecake every time. You get detailed information on cheesecake pans, ingredients, and appliances, as well as a special section of recipes for low-calorie, low-cholesterol ...
Easy Cheesecake Recipes: Delicious and Impressive Cheesecake Recipes That Everyone Can Enjoy (The Easy Recipe)
Echo By Books, 2014
When you're craving something sweet, creamy, thick, and rich, what do you reach for? Cheesecake of course! (At least we at Echo Bay Books do!) Cheesecake is one of the most decadent desserts out there, offering a creamy, custard-like cake surrounded by a crunchy, crumbly base layer. This delicious confection is not only sweet, it's sinfully smooth, with a texture and feel unlike any other dessert on the planet. And while a classic, plain ...
Cherry Cheesecake Murder (A Hannah Swensen Mystery)
Joanne Fluke
, 2011
There's no such thing as privacy in Lake Eden, but Hannah never thought things would go this far. Everyone has been telling her what to do ever since she got not one but two marriage proposals. Movie mania soon shoves Hannah's marriage dilemma into the background and even gives her cat a shot at stardom. The Cookie Jar serves as snack central with Main Street rented out for the week. She stirs lots of fresh gossip, whipping up treats for cast ...
Joy of Cheesecake, The (Barron's Educational Series)
Bovbjerg & Iggers
Barron's Educational Series
, 1989
The possibilities for cheesecake creativity are as rich as your imagination. By varying ingredients, proportions, and baking times, you can produce a cheesecake that is heavy or light, moist or dry, cakelike or smooth. This book contains chapters on ingredients and techniques to aid you in your improvisation.
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Working with middle school age children and being a grandparent I often find helpful tips such as the ones offered in this book very well worth the time it takes to read through... Read morePublished 1 month ago by Ronna Johnson
Good read..gives ideas and suggestions on how to communicate with kids.Published 4 months ago by holly brown
As a clinical psychologist w/ extensive experience working with children and families, I recommend this book for any parent. Read morePublished 4 months ago by Knolls949
I've read the book and I wanted to have the book. That's the reason that I bought. Nice. Very practicalPublished 7 months ago by Maria Carolina Pinto
Received book very quickly (seemed like within 2-3 days), and it was in very good shape. The content of the book is excellent as well. Read morePublished 8 months ago by Kristan
A co-worker recommended this to me as I was having difficulty with students in an after school program. Read morePublished 9 months ago by Rachel D.
I think everything they write is helpful. I recommend all their books, this one is especially good. I homeschool and need all the help I can get.Published 9 months ago by Melisa
I had to read this book for a Child Development class. It was an easy read and I found it to be helpful for my job as a preschool teacher's aide. Read morePublished 11 months ago by StacyMae


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Mark Berry begins a series of articles on the 9th Invest in ME International ME Conference in London, with a look at three presentations on autoimmunity
Discuss the article on the Forums.
Lipkin's Microbiome Research -- new or old topic? (split thread)
Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by Violeta, Feb 16, 2014.
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|By Business Wire
Article Rating:
|October 3, 2013 12:03 PM EDT
OneLogin, the innovator in enterprise identity management, today announced it has secured a $13 million round of Series B venture capital from lead investor The Social+Capital Partnership alongside returning investor Charles River Ventures. OneLogin will use the funds to continue its expansion in the United States, Europe and Asia-Pacific and to accelerate talent acquisition in these markets.
OneLogin provides a modern identity and access management (IAM) solution, which enables enterprises to easily manage employee and external user identities and control their access to applications in the cloud and behind the firewall. OneLogin's comprehensive turnkey solution includes strong authentication, single sign-on, federation, directory integration, user provisioning and reporting.
OneLogin has seen rapid adoption among companies, ranging from fast-growing start-ups like Dropbox, Pandora, Pinterest, Riot Games, Tableau Software, Tumblr, Uber, Yammer and Zendesk to established organizations such as AAA, Condé Nast, Gensler, Netflix, News Corp, PBS, Steelcase, The Carlyle Group and WestJet. OneLogin's largest customer has more than one million users deployed.
"The growth and rapid adoption of hundreds of SaaS products in the enterprise has made OneLogin's identity management a necessity," said Mamoon Hamid, general partner at The Social+Capital Partnership, who will be joining the company's Board of Directors. "Having invested in two of the most broadly used freemium applications in the enterprise, Box and Yammer, I was drawn to the freemium approach OneLogin has taken to gain rapid traction with a large number of enterprise users. We are leading this round because we see an enormous opportunity to build on this traction across companies of all sizes."
"IDC forecasts strong growth in the IAM SaaS market: from $702.7 million in 2011, reaching $1.4 billion by 2016," noted Sally Hudson, research director, security products and services at International Data Corporation (IDC). "We expect demand for cloud-based IAM services like OneLogin to be strong, driven in large part by OneLogin's ease of deployment as well as the burgeoning number of cloud applications now being adopted by enterprises across the globe."
"Many existing platforms view the cloud as a new opportunity and bring along issues tied to legacy infrastructure, but OneLogin is uniquely positioned because they have always been cloud-based, yet with a strong focus on integrating with an enterprise's on-premises security model," said Andrew Kellett, principal IT security analyst at Ovum. "OneLogin has kept overhead low and been able to focus on the goal of giving users more secure and straightforward access to the cloud, while also removing the need for further authentication."
OneLogin's track record of industry firsts is extensive and includes:
- Native iPad app for identity management
- Federated Cloud Search that enables secure, real-time search across public cloud applications such as Box, Dropbox, Google Apps, Salesforce, Yammer and Zendesk
- Mobile one-time password app with Push
- Real-time user synchronization between Active Directory and cloud apps
- Open source SAML toolkits that can be implemented in hours
"Customers are increasingly turning to OneLogin for features that cannot be found anywhere else in the market," said Thomas Pedersen, co-founder and chief executive officer at OneLogin. "Since founding the company, we have maintained an agility that has fostered ongoing innovation, allowing us to provide a highly differentiated solution that is exciting enterprises around the world."
"Since we first invested in OneLogin two years ago, hundreds of customers have turned to them to securely access and manage cloud applications," said Devdutt Yellurkar, Charles River Ventures partner and OneLogin's first institutional investor. "I'm proud to be an early investor and am excited about the way they continue to grow through ongoing product innovation and deep customer loyalty."
The company also announced that, in addition to Hamid, Amnon Landan has joined OneLogin's Board of Directors. Landan is former chairman and chief executive officer of Mercury Interactive. Mercury Interactive was a provider of enterprise IT optimization software which was bought by Hewlett-Packard for $4.5 billion in 2006. Landan is also the current chairman and co-founder of Capriza, a provider of mobility solutions for corporations and enterprises, and was awarded Forbes' Entrepreneur of the Year award in 2003.
About OneLogin
OneLogin is the innovator in enterprise identity management and provides the industry's most comprehensive solution for managing user identities, both in the cloud and behind the firewall. Unique capabilities like Cloud Search and OneLogin for iPad break down SaaS data silos and increase productivity. OneLogin's cloud identity platform comes complete with secure single sign-on for web, mobile and iPad, federated search, user provisioning, deep directory integration with real-time user sync, out-of-band multi-factor authentication, VPN integration and compliance reporting. OneLogin's catalog contains thousands of pre-integrated applications, including Adobe EchoSign, Asure Software, BMC Software, Box, Chrome River, Clarizen, CloudPassage, Coupa, DocuSign, Dropbox, Egnyte, EMC Aveksa, EMC Syncplicity, Google Apps, Hightail, HipChat, Hootsuite, Huddle, IdeaScale, Innotas, LiquidSpace, LiveHive, LotusLive, Marketo, Microsoft Office 365, NetSuite, New Relic, Oracle CRM On-Demand, Parature, PlayVox, Salesforce.com, Samanage, SD Elements, ServiceNow, SuccessFactors, SugarCRM, UserVoice, WebEx, Workday, Yammer, Zscaler and Zendesk. OneLogin, Inc. is backed by The Social+Capital Partnership and Charles River Ventures. Free Trial Available at: www.onelogin.com | Twitter: @onelogin.
Bit6 today issued a challenge to the technology community implementing Web Real Time Communication (WebRTC). To leap beyond WebRTC's significant limitations and fully leverage its underlying value to accelerate innovation, application developers need to consider the entire communications ecosystem.
Nov. 24, 2014 08:30 AM EST Reads: 1,180
SYS-CON Events announced today that Windstream, a leading provider of advanced network and cloud communications, has been named "Silver Sponsor" of SYS-CON's 16th International Cloud Expo®, which will take place on June 9–11, 2015, at the Javits Center in New York, NY. Windstream (Nasdaq: WIN), a FORTUNE 500 and S&P 500 company, is a leading provider of advanced network communications, including cloud computing and managed services, to businesses nationwide. The company also offers broadband, phone and digital TV services to consumers primarily in rural areas.
Nov. 23, 2014 07:30 PM EST Reads: 1,702
"There is a natural synchronization between the business models, the IoT is there to support ," explained Brendan O'Brien, Co-founder and Chief Architect of Aria Systems, in this SYS-CON.tv interview at the 15th International Cloud Expo®, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Nov. 23, 2014 12:00 PM EST Reads: 1,636
The major cloud platforms defy a simple, side-by-side analysis. Each of the major IaaS public-cloud platforms offers their own unique strengths and functionality. Options for on-site private cloud are diverse as well, and must be designed and deployed while taking existing legacy architecture and infrastructure into account. Then the reality is that most enterprises are embarking on a hybrid cloud strategy and programs. In this Power Panel at 15th Cloud Expo (http://www.CloudComputingExpo.com), moderated by Ashar Baig, Research Director, Cloud, at Gigaom Research, Nate Gordon, Director of T...
Nov. 23, 2014 07:45 AM EST Reads: 1,476
The definition of IoT is not new, in fact it's been around for over a decade. What has changed is the public's awareness that the technology we use on a daily basis has caught up on the vision of an always on, always connected world. If you look into the details of what comprises the IoT, you'll see that it includes everything from cloud computing, Big Data analytics, "Things," Web communication, applications, network, storage, etc. It is essentially including everything connected online from hardware to software, or as we like to say, it's an Internet of many different things. The difference ...
Nov. 22, 2014 10:00 PM EST Reads: 1,407
Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world.
Nov. 22, 2014 05:30 PM EST Reads: 1,458
An entirely new security model is needed for the Internet of Things, or is it? Can we save some old and tested controls for this new and different environment? In his session at @ThingsExpo, New York's at the Javits Center, Davi Ottenheimer, EMC Senior Director of Trust, reviewed hands-on lessons with IoT devices and reveal a new risk balance you might not expect. Davi Ottenheimer, EMC Senior Director of Trust, has more than nineteen years' experience managing global security operations and assessments, including a decade of leading incident response and digital forensics. He is co-author of t...
Nov. 22, 2014 05:30 PM EST Reads: 1,317
ARMONK, N.Y., Nov. 20, 2014 /PRNewswire/ -- IBM (NYSE: IBM) today announced that it is bringing a greater level of control, security and flexibility to cloud-based application development and delivery with a single-tenant version of Bluemix, IBM's platform-as-a-service. The new platform enables developers to build ap...
Nov. 22, 2014 05:30 PM EST Reads: 1,472
Explosive growth in connected devices. Enormous amounts of data for collection and analysis. Critical use of data for split-second decision making and actionable information. All three are factors in making the Internet of Things a reality. Yet, any one factor would have an IT organization pondering its infrastructure strategy. How should your organization enhance its IT framework to enable an Internet of Things implementation? In his session at Internet of @ThingsExpo, James Kirkland, Chief Architect for the Internet of Things and Intelligent Systems at Red Hat, described how to revolutioniz...
Nov. 21, 2014 09:15 PM EST Reads: 1,391
Technology is enabling a new approach to collecting and using data. This approach, commonly referred to as the "Internet of Things" (IoT), enables businesses to use real-time data from all sorts of things including machines, devices and sensors to make better decisions, improve customer service, and lower the risk in the creation of new revenue opportunities. In his General Session at Internet of @ThingsExpo, Dave Wagstaff, Vice President and Chief Architect at BSQUARE Corporation, discuss the real benefits to focus on, how to understand the requirements of a successful solution, the flow of ...
Nov. 21, 2014 08:00 PM EST Reads: 1,448
The security devil is always in the details of the attack: the ones you've endured, the ones you prepare yourself to fend off, and the ones that, you fear, will catch you completely unaware and defenseless. The Internet of Things (IoT) is nothing if not an endless proliferation of details. It's the vision of a world in which continuous Internet connectivity and addressability is embedded into a growing range of human artifacts, into the natural world, and even into our smartphones, appliances, and physical persons. In the IoT vision, every new "thing" - sensor, actuator, data source, data con...
Nov. 21, 2014 08:00 PM EST Reads: 1,396
"BSQUARE is in the business of selling software solutions for smart connected devices. It's obvious that IoT has moved from being a technology to being a fundamental part of business, and in the last 18 months people have said let's figure out how to do it and let's put some focus on it, " explained Dave Wagstaff, VP & Chief Architect, at BSQUARE Corporation, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Nov. 21, 2014 07:00 PM EST Reads: 1,301
Focused on this fast-growing market's needs, Vitesse Semiconductor Corporation (Nasdaq: VTSS), a leading provider of IC solutions to advance "Ethernet Everywhere" in Carrier, Enterprise and Internet of Things (IoT) networks, introduced its IStaX™ software (VSC6815SDK), a robust protocol stack to simplify deployment and management of Industrial-IoT network applications such as Industrial Ethernet switching, surveillance, video distribution, LCD signage, intelligent sensors, and metering equipment. Leveraging technologies proven in the Carrier and Enterprise markets, IStaX is designed to work ac...
Nov. 20, 2014 09:15 PM EST Reads: 1,382
C-Labs LLC, a leading provider of remote and mobile access for the Internet of Things (IoT), announced the appointment of John Traynor to the position of chief operating officer. Previously a strategic advisor to the firm, Mr. Traynor will now oversee sales, marketing, finance, and operations. Mr. Traynor is based out of the C-Labs office in Redmond, Washington. He reports to Chris Muench, Chief Executive Officer. Mr. Traynor brings valuable business leadership and technology industry expertise to C-Labs. With over 30 years' experience in the high-tech sector, John Traynor has held numerous...
Nov. 20, 2014 06:00 PM EST Reads: 1,343
The 3rd International @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that it is now accepting Keynote Proposals. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - computers, smartphones, tablets, and sensors - connected to the Internet by 2020. This number will continue to grow at a rapid pace for the next several decades.
Nov. 20, 2014 01:00 PM EST Reads: 1,590
The Internet of Things is not new. Historically, smart businesses have used its basic concept of leveraging data to drive better decision making and have capitalized on those insights to realize additional revenue opportunities. So, what has changed to make the Internet of Things one of the hottest topics in tech? In his session at @ThingsExpo, Chris Gray, Director, Embedded and Internet of Things, discussed the underlying factors that are driving the economics of intelligent systems. Discover how hardware commoditization, the ubiquitous nature of connectivity, and the emergence of Big Data a...
Nov. 20, 2014 12:30 PM EST Reads: 1,800
Almost everyone sees the potential of Internet of Things but how can businesses truly unlock that potential. The key will be in the ability to discover business insight in the midst of an ocean of Big Data generated from billions of embedded devices via Systems of Discover. Businesses will also need to ensure that they can sustain that insight by leveraging the cloud for global reach, scale and elasticity.
Nov. 18, 2014 09:00 PM EST Reads: 2,019
SYS-CON Events announced today that IDenticard will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. IDenticard™ is the security division of Brady Corp (NYSE: BRC), a $1.5 billion manufacturer of identification products. We have small-company values with the strength and stability of a major corporation. IDenticard offers local sales, support and service to our customers across the United States and Canada. Our partner network encompasses some 300 of the world's leading systems integrators and security s...
Nov. 18, 2014 08:15 PM EST Reads: 1,578
IoT is still a vague buzzword for many people. In his session at @ThingsExpo, Mike Kavis, Vice President & Principal Cloud Architect at Cloud Technology Partners, discussed the business value of IoT that goes far beyond the general public's perception that IoT is all about wearables and home consumer services. He also discussed how IoT is perceived by investors and how venture capitalist access this space. Other topics discussed were barriers to success, what is new, what is old, and what the future may hold. Mike Kavis is Vice President & Principal Cloud Architect at Cloud Technology Pa...
Nov. 18, 2014 01:30 PM EST Reads: 2,015
Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world. The next @ThingsExpo will take place November 4-6, 2014, at the Santa Clara Convention Center, in Santa Clara, California. Since its launch in 2008, Cloud Expo TV commercials have been aired and CNBC, Fox News Network, and Bloomberg TV. Please enjoy our 2014 commercial.
Nov. 13, 2014 05:00 AM EST Reads: 3,546


text: Europe 2 Bombings In Russia Raise Olympic Security Questions December 30, 2013 One of southern Russia's largest cities is reeling from two deadly bombings in the last 24 hours. The violence took place in Volgograd which is hundreds of miles from Sochi, where the Winter Olympics will be held. This has raised questions about whether these acts of terrorism are related to the staging of the Olympics. Listen Loading… 4:09 Download Playlist


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Add some diversity to your fitness program with these butt and hip exercises from the American Council on Exercise. We'll help you tone up those glutes and get that butt into shape. Choose from a wide variety of hip flexibility and strengthening exercises including glute bridges, BOSU lateral jumps and more. These exercises come with detailed instructions, step-by-step guidance and tutorials on proper equipment use. For full workout routines featuring butt and hip exercises, be sure to visit our Workouts section.
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A wide variety of field- and court-based sports require athletes to have high levels of speed, agility, reactivity and quickness (SARQ) to be the first to the ball and make the play. For those of us who just want to remain injury-free while participating in our favorite...
If you have a job that requires you to sit at a desk all day, it can be a challenge to get in enough exercise to reap the numerous health benefits of physical activity. From your commute to weekly meetings, here are five easy-to-incorporate ways to increase physical...
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This is the 'man in the hat', whom you can see in Arcade – Praça do Comérco. I noticed him pacing up and down for quite some time, and wondered what he could be doing there…
Lisbon, Portugal. Canon EOS 450D, Sigma 70 – 300 mm F4-5.6 DG lens.
Textures from here
A very strong image Ursula, great p/w as well!
Thankyou so much Rick! The man in the hat was quite an intriguing character :)
– Ursula Rodgers
Super shot, love the treatement.
Thanks so much Rebecca!
– Ursula Rodgers
Fantastic mood & treatment my friend!
Thankyou so much John! Hey, love your new profile pic!
– Ursula Rodgers
oh ursula… this is just amazing!! i just love it! great textures and colour too, nearly like a painting. well done, my friend x
Thankyou so much Sally! I'm really pleased you like it :))
– Ursula Rodgers
Nice work Ursula, gunna watch my back while out and about.. :))
Thanks Mark!
– Ursula Rodgers
Magnifico! Love the strong lines- the comp is awesome!
hey you! Hope things are good with you! Thanks so much, I'm glad you like it!
– Ursula Rodgers
Superb composition!!! Is this just cropped from the Arches, or a separate shot?
Thanks so much George! It's a separate shot of course! I used my 70 – 300 mm lens for this :)
– Ursula Rodgers
Great composition and mood Ursula, lovely light and treatment :)
Really appreciate it Trish, thankyou :))
– Ursula Rodgers
Hey, that's the guy wearing a hat featured in one of your previous pic ;)
Nice shot, interesting processing :)
I thought you'd appreciate this one Nicolas! The man in the hat really had stood out to me at the time, so I got a shot of him with the zoom lens too :)
– Ursula Rodgers
– Ursula Rodgers


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Monday 22 July 2013The school holidays are about to trigger the start of the busy summer getaway period for Exeter Airport and up to 25,000 passengers will be travelling through the terminal in the next seven days.
The week will see twelve and a half thousand passengers using the airport on variety of routes from the Isles of Scilly to as far away as Sharm el Sheikh.
South West flights from Exeter to St. Marys have increased to five a day and over the summer 11,000 passengers will use the service.
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Flybe, who have their headquarters at Exeter offer Alicante and Malaga five times a week and they fly to the other Spanish destinations of Barcelona and Palma. The airline operates half a dozen domestic routes including three flights a day to Manchester, which together with Paris and Amsterdam offer world-wide connections. Flybe also fly to Bergerac, Nice Rennes and Dusseldorf.
The Dusseldorf flights offer German tourists a weekly link to the South West and Austrian visitors this year are expected to top two and half thousand on their specially charted Niki flights.
Richard Broadley, Exeter Airport's commercial manager, said: "This looks as if it is going to be a bumper start to the summer holidays and one of our busiest for a few years. With the recent good weather our outbound passengers this year are already in the holiday mood but they are pleased to be getting away from the household chores and routine. We are all geared up for this summer but also looking ahead to 2014 as the new Thomson schedule was recently announced with Crete and more flights to Menorca."
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Publications (171)492.4 Total impact
Article: Lower aldosterone-renin ratio is a risk factor for total and cancer death in Japanese individuals: the Takahata study.[Show abstract] [Hide abstract]
ABSTRACT: A higher plasma aldosterone-renin ratio (ARR) is an established marker for screening for primary aldosteronism (PA). The association between higher ARR and mortality in a general population has not been fully explored. We here examined whether higher ARR is a risk factor for total and cause-specific mortality in a Japanese population.Clinical Endocrinology 10/2014; · 3.40 Impact Factor
Article: Long-term outcomes of 3 surgical adjuvants used for internal limiting membrane peeling in idiopathic macular hole surgery.[Show abstract] [Hide abstract]
ABSTRACT: Indocyanine green (ICG), an adjuvant used for peeling of the internal limiting membrane (ILM) during vitreous surgery for idiopathic macular hole (MH), has been reported to be toxic, possibly affecting postoperative visual acuity. We compared the long-term outcomes (within 2 years) of brilliant blue G (BBG), ICG, and triamcinolone acetonide (TA).Japanese journal of ophthalmology. 09/2014;
Article: Five-year incidence of branch retinal vein occlusion and its systemic and retinal risk associations: The Funagata study[Show abstract] [Hide abstract]
ABSTRACT: Purpose To determine retinal and systemic risk associations of branch retinal vein occlusion (BRVO) over 5 years in adult population-based cohort in Japan.Methods The Funagata study is a population-based longitudinal cohort study in Yamagata, Japan. In 2000-2, we performed baseline survey including fundus photography and systemic examination. In 2005-7, 5-year follow-up survey was performed and newly developed BRVO cases were determined. There were 954 persons who attended both baseline and 5-year follow-up survey; 878 persons had good quality fundus photographs suitable for grading (right eye only). Using multiple logistic regression models, retinal and systemic risk characteristics were determined.Results Mean age of study participants were 58.9 years old and 57.2% were women. Prevalence of diabetes and hypertension was 4.0% and 32.2%, respectively. There were 12 newly developed BRVO over 5- years (1.37%, right eyes only). In multiple logistic regression models including those significantly associated systemic risks, older age (adjusted odds ratio [OR] 1.15 per 1 year, 95% confidence interval [CI] 1.02-1.31, p=0.026) and waist-to-hip ratio (adjusted OR 6.15 per 0.1, 95%CI 1.50-25.3, p=0.012) remained as significant risk characteristics. Retinal vessel opacification was significantly associated with incident BRVO after adjusting for systemic risk characteristics.Conclusion In addition to older age, larger waist-to-hip ratio was identified as a modifiable systemic risk characteristic of 5-year incident BRVO. Retinal vessel opacification was also identified as a risk characteristic in the retina; there is a potential as a marker to predict BRVO. Commercial interestActa ophthalmologica 09/2014; 92(s253). · 2.44 Impact Factor
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ABSTRACT: To facilitate personalized health care for multifactorial diseases, risks of genetic and clinical/environmental factors should be assessed together for each individual in an integrated fashion. This approach is possible with the likelihood ratio (LR)-based risk assessment system, as this system can incorporate manifold tests. We examined the usefulness of this system for assessing type 2 diabetes (T2D). Our system employed 29 genetic susceptibility variants, body mass index (BMI), and hypertension as risk factors whose LRs can be estimated from openly available T2D association data for the Japanese population. The pretest probability was set at a sex- and age-appropriate population average of diabetes prevalence. The classification performance of our LR-based risk assessment was compared to that of a non-invasive screening test for diabetes called TOPICS (with score based on age, sex, family history, smoking, BMI, and hypertension) using receiver operating characteristic analysis with a community cohort (n = 1263). The area under the receiver operating characteristic curve (AUC) for the LR-based assessment and TOPICS was 0.707 (95% CI 0.665-0.750) and 0.719 (0.675-0.762), respectively. These AUCs were much higher than that of a genetic risk score constructed using the same genetic susceptibility variants, 0.624 (0.574-0.674). The use of ethnically matched LRs is necessary for proper personal risk assessment. In conclusion, although LR-based integrated risk assessment for T2D still requires additional tests that evaluate other factors, such as risks involved in missing heritability, our results indicate the potential usability of LR-based assessment system and stress the importance of stratified epidemiological investigations in personalized medicine.Endocrine Journal 07/2014; 61. · 2.23 Impact Factor
Article: Minimally Invasive Scleral Fixation of an IOL Using a Suture Thread Inserter Combined With 25-Gauge Vitrectomy.[Show abstract] [Hide abstract]
ABSTRACT: To evaluate a novel surgical technique for IOL fixation using a newly designed suture thread inserter.Ophthalmic surgery, lasers & imaging retina. 06/2014;
Article: "Pleats Fold" Technique of Amniotic Membrane Transplantation for Management of Corneal Perforations.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to examine the efficacy and surgical success rates of amniotic membrane (AM) transplantation performed for corneal perforation closure using a novel technique. This study included 6 eyes from 6 patients with corneal perforation who had received AM transplantation between May 2011 and April 2012. The AM was collected from human placenta shortly after cesarean section. In surgery, the AM was folded into pleats and used to plug the wound using 10-0 nylon suture. The wound was then covered with an AM seal. After reepithelialization and AM scarring, sutures were removed. All 6 patients had successful wound closure with 1 surgery. One patient underwent optical keratoplasty later, and 1 patient required combined preserved sclera transplantation. The absolute value of astigmatism decreased to <3.50 diopters (D) 3 months after surgery and to <3.00 D 6 months after surgery in patients with peripheral AM transplants. The visual acuity gradually improved over the first 3 months after surgery, and visual acuity gains were maintained at the 6-month postoperative mark. The AM transplantation procedure may be an effective option for treating corneal perforations when the wound is circular or irregular, except for incised wounds. Our "Pleats Fold" AM transplantation technique can achieve definite closure and effectively repair wounds of various sizes. Postoperative astigmatic values were acceptable. Therefore, we recommend this procedure for repairing lesions <3 mm in diameter that do not involve the central cornea and that are infection free.Cornea 04/2014; · 1.75 Impact Factor
Article: [Series: Clinical study from Japan and its reflections; diabetic retinopathy and microalbuminuria can predict macroalbuminuria and renal function decline in Japanese type 2 diabetic patients: Japan Diabetes Complications Study (JDCS)].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 04/2014; 103(4):987-93.
Article: Contribution of Corneal Neovascularization to Dendritic Cell Migration into the Central Area during Human Corneal Infection.[Show abstract] [Hide abstract]
ABSTRACT: Compared with the peripheral corneal limbus, the human central cornea lacks blood vessels, which is responsible for its immunologically privileged status and high transparency. Dendritic cells (DCs) are present in the central avascular area of inflamed corneas, but the mechanisms of their migration to this location are poorly understood. Here, we investigated the contribution of vessel formation to DC migration into the central cornea, and analyzed the DC chemotactic factors produced by human corneal epithelial (HCE) cells. Using human eyes obtained from surgical procedures, we then assessed vessel formation, DC distribution, and activin A expression immunohistochemically. The results demonstrated increased numbers of vessels and DCs in the central area of inflamed corneas, and a positive correlation between the number of vessels and DCs. Activin A was expressed in the subepithelial space and the endothelium of newly formed blood vessels in the inflamed cornea. In infected corneas, DCs were present in the central area but no vascularization was observed, suggesting the presence of chemotactic factors that induced DC migration from the limbal vessels. To test this hypothesis, we assessed the migration of monocyte-derived DCs toward HCE cell supernatants with or without lipopolysaccharide (LPS) stimulation of HCE cells and inflammatory cytokines (released by HCE cells). DCs migrated toward tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and activin A, as well as LPS-stimulated HCE cell supernatants. The supernatant contained elevated TNF-α, IL-6, and activin A levels, suggesting that they were produced by HCE cells after LPS stimulation. Therefore, vessels in the central cornea might constitute a DC migration route, and activin A expressed in the endothelium of newly formed vessels might contribute to corneal vascularization. Activin A also functions as a chemotactic factor, similar to HCE-produced TNF-α and IL-6. These findings enhance our understanding of the pathophysiology of corneal inflammation during infection.PLoS ONE 01/2014; 9(10):e109859. · 3.53 Impact Factor
Article: [Management of diabetic retinopathy and diabetic maculopathy in elderly patients with diabetes mellitus].[Show abstract] [Hide abstract]
ABSTRACT: The world's population is aging, and simultaneously, the prevalence of diabetes mellitus worldwide is rapidly increasing. Therefore, the clinical management of diabetic retinopathy and diabetic maculopathy in elderly patients with diabetes is increasingly becoming more important. Therefore, collaboration between ophthalmologists and physicians is mandatory. The international clinical diabetic retinopathy and macular edema disease severity scales are very useful for information sharing between ophthalmologists and diabetologists. This review describes a strategy to assess symptoms of diabetes, including the clinical course of retinopathy and maculopathy, pathological changes, and pathogenesis, as well as details an updated treatment modality. Elderly patients tend to present with multiple complications that should be considered by the management team.Nippon rinsho. Japanese journal of clinical medicine 11/2013; 71(11):2005-9.
Article: Three-dimensional imaging of the inner limiting membrane folding on the vitreomacular interface in diabetic macular edema.[Show abstract] [Hide abstract]
ABSTRACT: To report the findings of fine folds on the retina obtained by spectral-domain optical coherence tomography (OCT). A retrospective non-comparative case series; 26 eyes of diabetic macular edema (DME) patients who underwent vitrectomy were observed using three-dimensional (3D) images of OCT preoperatively and postoperatively. The specimens were investigated immunohistochemically. Using only tomography, non-tractional vitreoretinal interfaces were observed in 15 eyes and tractional vitreoretinal interfaces in the other 11 eyes. Using 3D imaging, we observed fine folds in 11 eyes among 15 cases showing non-tractional interfaces. Based on these findings, the state of the vitreoretinal interface was classified into 3 patterns. Group 1, both tomography and 3D imaging showed smooth retinal surfaces. Group 2, tomography showed a smooth retinal surface, but 3D imaging showed fine folds on the retina. Group 3, both tomography and 3D imaging showed a tractional vitreoretinal interface with an obvious epiretinal membrane and/or taut posterior vitreous cortex. The fine folds in group 2 disappeared and macular edema improved after inner limiting membrane (ILM) peeling, and the CRT of groups 2 and 3 reduced significantly. The fine folds were confirmed to involve the ILM because type IV collagen expression was detected in the surgically obtained specimens. We observed tangential fine folds of the ILM. These were detected by using only 3D imaging, and might be useful for investigating the optimal indication of vitrectomy for DME.Japanese Journal of Ophthalmology 10/2013; · 1.27 Impact Factor
Article: Cohort Profiles: The Japan Diabetes Complications Study: a long-term follow-up of a randomised lifestyle intervention trial of type 2 diabetesInternational Journal of Epidemiology 08/2013; · 6.98 Impact Factor
Article: New developments in medical education for the realization of next-generation personalized medicine: concept and design of a medical education and training program through the genomic cohort study.Journal of Human Genetics 06/2013; · 2.53 Impact Factor
Article: The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies.[Show abstract] [Hide abstract]
ABSTRACT: The impact of cryptic relatedness (CR) on genomic association studies is well studied and known to inflate false-positive rates as reported by several groups. In contrast, conventional epidemiological studies for environmental risks, the confounding effect of CR is still uninvestigated. In this study, we investigated the confounding effect of unadjusted CR among a rural cohort in the relationship between environmental risk factors (body mass index, smoking status, alcohol consumption) and systolic blood pressure. We applied the methods of population-based whole-genome association studies for the analysis of the genome-wide single nucleotide polymorphism data in 1622 subjects, and detected 20.2% CR in this cohort population. In the case of the sample size, approximately 1000, the ratio of CR to the population was 20.2%, the population prevalence 25%, the prevalence in the CR 26%, heritability for liability 14.3% and prevalence in the subpopulation without CR 26%, the difference of estimated regression coefficient between samples with and without CR was not significant (P-value = 0.55). On the other hand, in another case with approximately >20% heritability for liability, we showed that confounding due to CR biased the estimation of exposure effects.Molecular genetics & genomic medicine. 05/2013; 1(1):45-53.
Article: Predicting Macro- and Microvascular Complications in Type 2 Diabetes: The Japan Diabetes Complications Study/the Japanese Elderly Diabetes Intervention Trial risk engine.[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE To develop and validate a risk engine that calculates the risks of macro- and microvascular complications in type 2 diabetes.RESEARCH DESIGN AND METHODS We analyzed pooled data from two clinical trials on 1,748 Japanese type 2 diabetic patients without diabetes complications other than mild diabetic retinopathy with a median follow-up of 7.2 years. End points were coronary heart disease (CHD), stroke, noncardiovascular mortality, overt nephropathy defined by persistent proteinuria, and progression of retinopathy. We fit a multistate Cox regression model to derive an algorithm for prediction. The predictive accuracy of the calculated 5-year risks was cross-validated.RESULTSSex, age, HbA(1c), years after diagnosis, BMI, systolic blood pressure, non-HDL cholesterol, albumin-to-creatinine ratio, atrial fibrillation, current smoker, and leisure-time physical activity were risk factors for macro- and microvascular complications and were incorporated into the risk engine. The observed-to-predicted (O/P) ratios for each event were between 0.93 and 1.08, and Hosmer-Lemeshow tests showed no significant deviations between observed and predicted events. In contrast, the UK Prospective Diabetes Study (UKPDS) risk engine overestimated CHD risk (O/P ratios: 0.30 for CHD and 0.72 for stroke). C statistics in our Japanese patients were high for CHD, noncardiovascular mortality, and overt nephropathy (0.725, 0.696, and 0.767) but moderate for stroke and progression of retinopathy (0.636 and 0.614). By combining macro- and microvascular risks, the classification of low- and high-risk patients was improved by a net reclassification improvement of 5.7% (P = 0.02).CONCLUSIONS The risk engine accurately predicts macro- and microvascular complications and would provide helpful information in risk classification and health economic simulations.Diabetes care 02/2013; · 7.74 Impact Factor
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ABSTRACT: BACKGROUND:: Antioxidants and dietary fiber are postulated to have preventive effects on diabetic retinopathy, but evidence is lacking. We investigated this association in a cohort with type 2 diabetes 40-70 years of age with hemoglobin (Hb)A1C ≥6.5%, originally part of the Japan Diabetes Complications Study. METHODS:: After excluding people who did not respond to a dietary survey and patients with diabetic retinopathy or a major ocular disease at baseline, we analyzed 978 patients. Baseline dietary intake was assessed by a food frequency questionnaire based on food groups and 24-hour dietary records. Primary outcome was incident diabetic retinopathy determined using international severity scales. RESULTS:: Mean fruit intake in quartiles ranged from 23 to 253 g/day, with increasing trends across quartiles of fruit intake for vitamin C, vitamin E, carotene, retinol equivalent, dietary fiber, potassium, and sodium. Mean energy intake ranged from 1644 to 1863 kcal/day, and fat intake was approximately 25%. HbA1C, body mass index, triglycerides, and systolic blood pressure were well controlled. During the 8-year follow-up, the numbers of incident cases of diabetic retinopathy from the first through the fourth quartiles of fruit intake were 83, 74, 69, and 59. Multivariate-adjusted hazard ratios for the second, third, and fourth quartiles of fruit intake compared with the first quartile were 0.66 (95% confidence interval = 0.46-0.92), 0.59 (0.41-0.85), and 0.48 (0.32-0.71) (test for trend, P < 0.01). There was no substantial effect modification by age, sex, HbA1C, diabetes duration, overweight, smoking, and hypertension. Risk for diabetic retinopathy declined with increased intake of fruits and vegetables, vitamin C, and carotene. CONCLUSION:: Increased fruit intake in ranges commonly consumed was associated with reduced incident diabetic retinopathy among patients adhering to a low-fat energy-restricted diet.Epidemiology (Cambridge, Mass.) 01/2013; · 5.51 Impact Factor
Article: Correlation between the characteristics of acceleration and visco elasticity of artery wall under pulsatile flow conditions (physical meaning of I* as a parameter of progressive behaviors of atherosclerosis and arteriosclerosis).[Show abstract] [Hide abstract]
ABSTRACT: Previously, I* parameter has been proposed to diagnose noninvasively the progressive degree of atherosclerosis which is considered to concern the discrimination of the progressive degree of visco elasticity of blood vessel wall. However, the detailed physical meaning of this parameter has not yet been clarified. In this paper, the theoretical analysis and experiments were conducted and the detailed physical meaning of I* parameter was clarified. The following results were obtained. I* parameter was found to well correlate with the progressive degree of visco elasticity of blood vessel wall characterized by the Ith* parameter derived based on the analysis of visco elasticity in this paper. That is, I* was found to have the physical meaning of representing the progressive degree of visco elasticity of blood vessel wall. On the basis of this results, using clinical data, two dimensional representation between the progressive degree of visco elasticity of blood vessel wall by I* and the decrease in the rigidity of blood vessel wall by PWV was found to be useful to conduct much more detailed diagnosis of atherosclerosis.Bio-medical materials and engineering 01/2013; 23(1):75-91. · 1.09 Impact Factor
Article: Diabetic retinopathy and microalbuminuria can predict macroalbuminuria and renal function decline in Japanese type 2 diabetic patients: Japan Diabetes Complications Study (JDCS)[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE To examine the interactive relationship between diabetic retinopathy (DR) and diabetic nephropathy (DN) in type 2 diabetic patients, and to elucidate the role of DR and microalbuminuria on the onset of macroalbuminuria and renal function decline.RESEARCH DESIGN AND METHODS We explored the effects of DR and microalbuminuria on the progression of DN from normoalbuminuria and low microalbuminuria (<150 mg/gCr) to macroalbuminuria or renal function decline in the Japan Diabetes Complications Study (JDCS), which is a nationwide randomized controlled study of type 2 diabetic patients focusing on lifestyle modification. Patients were divided into four groups according to presence or absence of DR and MA: normoalbuminuria without DR [NA(DR-)] (n = 773), normoalbuminuria with DR [NA(DR+)] (n = 279), microalbuminuria without DR [MA(DR-)] (n = 277), and microalbuminuria with DR [MA(DR+)] (n = 146). Basal urinary albumin-to-creatinine ratio and DR status were determined at baseline and followed for a median of 8.0 years.RESULTSAnnual incidence rates of macroalbuminuria were 1.6/1,000 person-years (9 incidences), 3.9/1,000 person-years (8 incidences), 18.4/1,000 person-years (34 incidences), and 22.1/1,000 person-years (22 incidences) in the four groups, respectively. Multivariate-adjusted hazard ratios of the progression to macroalbuminuria were 2.48 (95% CI 0.94-6.50; P = 0.07), 10.40 (4.91-22.03; P < 0.01), and 11.55 (5.24-25.45; P < 0.01) in NA(DR+), MA(DR-), and MA(DR+), respectively, in comparison with NA(DR-). Decline in estimated glomerular filtration rate (GFR) per year was two to three times faster in MA(DR+) (-1.92 mL/min/1.73 m(2)/year) than in the other groups.CONCLUSIONS In normo- and low microalbuminuric Japanese type 2 diabetic patients, presence of microalbuminuria at baseline was associated with higher risk of macroalbuminuria in 8 years. Patients with microalbuminuria and DR showed the fastest GFR decline. Albuminuria and DR should be considered as risk factors of renal prognosis in type 2 diabetic patients. An open sharing of information will benefit both ophthalmologists and diabetologists.Diabetes Care 01/2013; · 7.74 Impact Factor
Article: Pathological findings of pemphigus vulgaris showing giant cobblestone-like conjunctival papillae.[Show abstract] [Hide abstract]
ABSTRACT: To describe the pathophysiological findings of a patient with pemphigus vulgaris (PV) showing giant conjunctival papillae. A 64-year-old man who had mucosal-dominant PV with giant conjunctival papillae, resembling those of vernal keratoconjunctivitis (VKC), underwent an ophthalmological workup. The clinical and pathological findings were investigated. Ophthalmic interventions were unable to provide the desired beneficial effects, and multiple excisions were necessary to remove the proliferative conjunctival lesions. Histopathological investigations of the excised tissues demonstrated acantholysis and a subconjunctival infiltration with numerous inflammatory cells such as lymphocytes, plasma cells, and neutrophils. However, in contrast to typical VKC, mast cells and eosinophils were rarely found in the subconjunctival tissues. Direct immunofluorescent staining showed a significant deposition of immunoglobulin G and complement component 3 in the epithelial intercellular substance, consistent with mucosal-dominant PV. Then, the patient was hospitalized because of oral erosion exacerbation and malnutrition. Because of the patient's declining general condition, we administered an increasing dose of a systemic steroid with an intravenous immunoglobulin, after which his ocular lesions and symptoms improved. The histological conjunctival papilla findings were quite different from those of VKC papillae. If PV causes a lesion in a patient, systemic immunosuppression might be more effective than topical ophthalmic treatment because of overall immunological involvement.Case reports in ophthalmology. 01/2013; 4(3):114-21.
Article: Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy: The Japan Diabetes Complications Study.[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE: Diabetic retinopathy (DR) is linked to cardiovascular risk in diabetic patients. This study examined whether mild-stage DR is associated with risk of coronary heart disease (CHD) and stroke in type 2 diabetic patients of the Japan Diabetes Complications Study (JDCS). DESIGN: Prospective cohort study. PARTICIPANTS: In the JDCS, there were 2033 Japanese persons with type 2 diabetes free of cardiovascular diseases at baseline. METHODS: Diabetic retinopathy was ascertained from clinical and photographic grading (70%) following the international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Incident CHD and stroke were followed up prospectively annually up to 8 years. MAIN OUTCOME MEASURES: Eight-year incidence of CHD and stroke compared between persons with or without DR. RESULTS: After adjusting for traditional cardiovascular risk factors, persons with mild to moderate nonproliferative DR had a higher risk of CHD (hazard ratio [HR], 1.69; 95% confidence interval [CI], 1.17-2.97) and stroke (HR, 2.69; 95% CI, 1.03-4.86). Presence of retinal hemorrhages or microaneurysms was associated with risk of CHD (HR, 1.63; 95% CI, 1.04-2.56) but was not associated with stroke (P = 0.06). Presence of cotton-wool spots was associated with risk of incident stroke (HR, 2.39; 95% CI, 1.35-4.24) but was not associated with CHD (P = 0.66). When information about DR was added in the prediction models for CHD and stroke based on traditional cardiovascular risk factors, the area under the receiver operating curve improved from 0.682 to 0.692 and 0.640 to 0.677, and 9% and 13% of persons were reclassified correctly for CHD and stroke, respectively. CONCLUSIONS: Type 2 diabetic patients with even a mild stage of DR, such as dot hemorrhages, are already at higher risk of CHD and stroke independent of traditional risk factors. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.Ophthalmology 11/2012; · 5.56 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Hyperhomocysteinaemia is associated with chronic obstructive pulmonary disease (COPD). However, the relationship between plasma homocysteine (Hcy) levels and spirometric measures has not been investigated in a general population. We aimed to determine whether Hcy levels are predictive for a rapid decline in lung function among healthy current smokers.Blood sampling and spirometry were performed on subjects (n=3,257), participating in a community-based annual health check in Takahata, Japan, from 2004 to 2006. Spirometry was re-evaluated in 147 male current smokers in 2009.On initial assessment, percent predicted forced vital capacity (%FVC) and forced expiratory volume in 1 s (%FEV1) correlated inversely with Hcy levels, and were predictive for Hcy levels, independent of various clinical factors. Hcy levels were higher in subjects with restrictive, obstructive, or mixed ventilatory disorders. Additionally, Hcy levels were higher in subjects with mixed ventilatory disorders, compared with restrictive or obstructive disorders. On follow-up, subjects showing a decline in FEV1 had higher Hcy levels than those who did not. Logistic regression analysis indicated that Hcy levels were predictive for a decline in FEV1.%FVC and % FEV1 were significantly associated with Hcy levels, and hyperhomocysteinaemia predicted the annual rate of decline in FEV1 among male smokers.European Respiratory Journal 11/2012; · 6.36 Impact Factor
Top Journals
Yamagata University
Ямагата, Yamagata, Japan
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Tohoku University
Sendai, Kagoshima-ken, Japan
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Japan Society for the Promotion of ScienceEdo, Tōkyō, Japan
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Universidade Federal de São PauloSan Paulo, São Paulo, Brazil
The University of Tokyo
Tōkyō, Japan
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Japanese Foundation for Cancer ResearchEdo, Tōkyō, Japan


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October 14th 1:10am
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Catching on to men's subtle (and not-so-subtle) cues can be an easier way to get their message and avoid unnecessary heartbreak.View Pics / Read More
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August Buddies
Find a Conversation
|Tue, 07-06-2010 - 3:13pm
Hello Ladies,
Well here we are again - getting ready to start another IVF. I don't know if anyone remembers me - I had my IVF in Jan and although we got a BFP, it ended in miscarriage at week 10. It was pretty devestating, since we had gone in for u/s, even seen the heartbeat and had just been released to obgyn.
We are ready to start again, so pretty excited to be cycling. Anyone else cycling with me in August?
So now waiting for Day 1 of my period so I can call to schedule my mock transfer. Then BCP for 2 weeks so I should be doing injections by early August.
I've also been doing acupuncture since early June just to keep me relaxed. So far it's working, I feel pretty good about going into this and keeping my fingers crossed.
So who's cycling with me in August???.....lol. Good luck to us all, ladies, and I'm here to offer my support to you.
Me, 38, dh, 35
3 IUI's - BFN
IVF #1 - Jan '08 - BFP - beautiful baby boy born 10/10/08
IVF cycle #2 - TTC #2 - Jan 2010
Transferred 2 embies (3dt) on 1/12, beta on 1/26, BFP!!!, beta 154, 2nd beta on 1/28, Beta #2, 337, u/s - saw heartbeat, but miscarried at 10 weeks, d & c on 3/8/10 :(
IVF #3 - summer 2010
|Mon, 08-09-2010 - 9:10pm
I just wanted to wish all of you ladies cycling in August the best of luck!
|Tue, 08-10-2010 - 9:47am
Hi, all! I can't get the formatting right on the chart, but maybe y'all can update my info in the chart for me? I'm officially done with my stims! I'm doing the ganirelex protocol, which seems really short, since I started cycle day 2 with no suppression or anything- it's going fast. I did gonal-f (one low dose in the evening only) for cycle days 2-9, ganirelex was added in (one shot each morning) for days 6-9. My estradiol levels increased nicely, but never got too high (the dr lowered my gonal-f dose nearly daily to ensure it didn't spike up too high, since he knew I'm at risk of OHSS since I had 41+ antral follies on day 2, lol!)
Things have gone really well- as of yesterday morning, I had 15+ mature (or nearly mature) follies, and at least as many slightly smaller follies. I did the trigger shot last night at 9:30 pm and will go in for egg retrieval tomorrow (Wednesday) morning at 9:30 am. I'm so excited to be moving so quickly!!! So, embryo transfer will be Saturday (3dt) or HOPEFULLY Monday (5dt) if we have success with fertilization... My dr will ICSI every mature egg they get, so we're not taking any chances.
Now, of course, my new worry is that I'll ovulate EARLY, before surgery tomorrow morning. I'm so afraid that everything will get messed up right here at the end! But my fingers are crossed, and I'll update on Thursday, once I get the embryologist's report. :) Good luck, everyone!
03/08- BFP w/ NO HELP, but m/c at 10 wks
3 IUIs- BFN
05/10- BFP w/ NO HELP, but chem preg at 4 wks
1st IVF in Aug. 2010- Fingers Crossed!
|Tue, 08-10-2010 - 12:40pm
|Tue, 08-10-2010 - 12:50pm
Started stims last night, along with menopur (to prevent early ovulation).
|Tue, 08-10-2010 - 12:54pm
Hello ladies,
Checking in to say hello and good luck to everyone.
I am STILL waiting for AF.
|Tue, 08-10-2010 - 4:11pm
Chris - hope you get to start soon, I know how frustrating it is.
I'm new here, and I don't know all the acronyms, but I'll try to give you a lil of my history:
1st failed IVF 6 yrs ago
adopted 2 brothers 12/2004 who were ages 3 and 5 (now 9 and 11)
ESSURE procedure (perm seal tubes with coils) 12/24/09 followed by 3 month wait prior to being able to start cycle
5/2010 - cancel middle of stim due to bad FSH/E2/AMH
7/2010 - New cycle with no BCP, stim with Follistem, Menopur, Estrace, Dethamethasone(sp?)
Follicles very hard to see due to lots of fluid - only 3 on rt and 1 on left could be seen - successful stim, good growth - sizes 20, 18, 16 and 15
8/06/10 - ER 4 eggs; 8/09/10 - ET 3 embryos.......PT on 8/20/2010 !!!!!!!
Hoping to see more positive successes here - starting with me of course, lol!
Age 38 - dh/39
|Wed, 08-11-2010 - 12:01pm
Hi All,
Sounds like everyone is well on their way! I'm still on BCP's and now Estrace. Won't start anything else until 8/19. Can't handle this waiting. I'm an emotional wreck but not necessarily because of the estrogen or BCP's. I need to figure out how to relax more. The acupuncture helps, but it's only 1x/week.
Ginger - how cool that you are starting your stims today!
Hannah - yay that meds arrived. It can all be overwhelming I know. But, at least you're one step closer. I see you are on dexamethasone. I'll be on prednisone. I've been trying to research the difference. But, different docs I guess have their preferences.
Leah - I don't know what time zone you are in, but hope your ER goes smoothly! 15 follies is soooo awesome!
1 Clomid cycle - 2006 - BFN
3 IUI's - 2006 - BFN
Aug/Sept - new RE, new IVF attempt, new hope


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***NEW NAME***NEW OWNERS***THE TRUE UP NORTH***McGuire's Resort in Cadillac Michigan… READ MORE
***RENOVATION UPDATES***Great things are happening at Evergreen… READ MORE
Home for the Holidays Room SpecialToo many guests and not enough couches? … READ MORE
HERO DiscountTo honor all the heroes out there, we are… READ MORE
Downhill Ski PackageSki Caberfae Peaks while staying in comfort.… READ MORE
Sled Head PackageCadillac, MI offers over 200 miles of groomed… READ MORE
Elopement PackageLooking to elope? Our resort offers you… READ MORE
Buy two nights, get the 3rd & 4th half offTreat yourself to some time away at Evergreen… READ MORE
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Specials & Packages
*All prices are based on double occupancy. Taxes not included (Weekends are considered Friday and Saturday nights. Price does adjust during Christmas week and weekends after the first of the year). Some restrictions may apply
McGuire's Resort in Cadillac Michigan will be officially called Evergreen Resort on November 1st, 2014. Read the full press release here.
Great things are happening at Evergreen Resort daily. Renovations continue as we strive to offer a valuable product to our guests. Currently, the following renovations are completed:
- 33 guestrooms
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- New golf carts
- Curly's Sports Pub updates
Take a look at our video of the updates.
Starting October 6th renovation of 18 rooms in the White Pine building, phase one of a phase two project. Rebuilding from the studs up.
Keep checking back for more exciting updates as we continue to improve! Our new owners are committed to offering a superior product that Cadillac, MI can be proud of.
Home for the Holidays Room Special
Too many guests and not enough couches? Book our Home for the Holidays rate for only $69 for standard rooms, upgrades available for additional charge. Available November 21 -29, 2014 and December 21-25, 2014.
Use PROMOTIONAL CODE: HOME to book online or call the hotel directly at (800) 632-7302.
Remember that we serve our guests a complimentary hot breakfast buffet so you won't have too!
HERO Discount
To honor all the heroes out there, we are offering a 20% discount off our regular room rates. This discount applies to all military, first responders and teachers. All you have to do is show us your applicable identification at check-in so we can thank you for your service to our country.
Please note that blackout dates may apply.
Downhill Ski Package
Ski Caberfae Peaks while staying in comfort. This package includes a one-day adult lift ticket for each registered adult, overnight accommodations and continental breakfast buffet in the morning.
While you are here, you can take advantage of any or all of the amenities that the resort has to offer, including:
- Indoor pool, hot tub and sauna
- Friday and Saturday night bonfires (weather permitting)
- Curly's Sports Pub with 60 inch flat screen tv's
- Our on-site cross country ski trails. Rentals available along with snowshoes and sleds.
Package pricing is based on the number of people in the room. Teen and youth lift tickets can be purchased directly from Caberfae Peaks.
Sled Head Package
Cadillac, MI offers over 200 miles of groomed trails that can be accessed directly from our property. Book our Sled Head package and receive overnight accommodations, continental breakfast buffet, a $20 food voucher and a $20 gas card per room per night. Parking is free so hitch your trailer and come hit the trails. Don't have a sled? No problem. We partner with M & M Rentals who can deliver a sled to you. NEW FOR THE 2015 SEASON: you can gas up your sleds right here on our property.
While your here, you can take advantage of any or all of the amenities that the resort has to offer, including:
- Indoor pool, hot tub and sauna
- Friday & Saturday night bonfires (weather permitting)
- Curly's Sports Pub, with 60 inch flat screen t.v's.
- Our on-site cross country ski trails with in house rentals available
So make plans today to come up and stay and play at Evergreen Resort.
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Looking to elope? Our resort offers you a stress-free package so you can focus on starting your life together as husband and wife. Priced at $385 inclusive of all tax, gratuity and assessment, your package includes:
- Use of our Terrace arbor for your intimate wedding ceremony
- Your own personal wedding consultant to assist you with all your wedding details
- Two nights lodging in a deluxe suite
- Dinner for two in our restaurant on your wedding night
- One bottle of champagne with two souvenir glasses
- Chocolate covered strawberries
- A special wedding gift from the resort
Call our Sales Team today to book your elopement, (800) 634-7302.
This promotion is valid for new bookings only, advance reservations accepted 30 days prior to arrival, package not transferable. Any package component not used is not redeemable for cash, not valid in conjunction with any other specials or promotions and all packages are subject to availability of both the Arbor and hotel accommodations.
Buy two nights, get the 3rd & 4th half off
Treat yourself to some time away at Evergreen Resort and enjoy not having to make your bed, cook or clean. Our resort offers plenty of things to keep you busy:
- Golf our 18 hole course or our 9 hole course
- Driving range
- Indoor pool, whirlpool and sauna
- Basketball, tennis, shuffle board
- Hiking trails
- Terrace Room restaurant and Curly's Sports Pub
Pay full price for the first two nights and receive the third night half off our Best Available rate.
Couples Getaway Package
Looking for a chance to get away? Escape to Northern Michigan for some relaxation. Enjoy dinner for two at one of our on-site restaurants. After dinner sit by the fireplace to relax and enjoy each other's company or take a stroll on one of our nearby nature trails. Sleep soundly in one of our comfortable rooms and wake up to a warm breakfast.
*Packages start as low as $130 per room plus taxes
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Gas prices got you down? Our "Gas4You" package is just what you need. This special package includes one night's accommodations, hot breakfast in the morning, and a $50 gas card.
*Packages start as low as $129 per room plus taxes. One gas card per room, per paid night.
*All prices are based on double occupancy. Taxes not included (Weekends are considered Friday and Saturday nights. Price does adjust during Christmas week and weekends after the first of the year). Some restrictions may apply


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Avanti Skin Center of Willow Bend
Helmed by medical director Dr. Safoora Harandi, Avanti Skin Center of Willow Bend's team of technicians, medical aestheticians, and registered nurses helps clients look and feel their freshest with facials, injectable beauty bolsterers, and cosmetic laser treatments. Strict sanitation policies and up-to-date laser gear add an air of clinical trustworthiness to the epidermal oasis, where potted plants ornament an earth-toned interior and lobby splashed with light from floor-to-ceiling windows.
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Getty Images When Hittman signed to Aftermath Entertainment, he was known as Dr. Dre's protege. The super producer and rapper spoke of ...Read More
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