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You would think that all marketers know that in competitive markets, their brand message must be different and better than that of their competitors. This axiom is equally true in destination and tourism, because travelers have so many choices. Yet it seems that no destination is able to really pull off being different and better -- not, at any rate, from the perspective of the traveler. What do traveling consumers see and hear, and what are they choosing? How do they arrive at a destination choice? What do the choices present to them? Based on what I've seen, the destinations have done themselves no favors in helping travelers make a choice. That's because few destinations offer a true choice. In considering just a few U.S. states, slogans run from "What People Are Talking About" (Utah) to "Just Right" (South Carolina). What do those mean? How do they help a consumer make a choice? There are also the ones that are too clever (meaning, they have no meaning and feel trite), such as Alabama's "Sweet Home" and Georgia's "On My Mind." (Get it? Nudge, nudge.) They do nothing to move the needle. Instead, consider the questions travelers ask themselves to make a selection. Seasonality certainly plays a part. In the summer months, most seek a destination with an experience or a theme (visiting a national park or a theme park, for example). Winter months draw adventurers looking to amplify the climate (skiing or snowboarding, for example) or counter the home climate (a tropical destination). Yet the destinations' messages lack the ability to differentiate one from another. What tropical destination does not have (or pretend to have) white sandy beaches, palm trees, friendly locals and azure blue water? Does the traveler understand the difference that each destination is trying to create? Is that really any difference? What does the traveler believe are the differences between Jamaica and Turks and Caicos? Between the Cayman Islands and the Bahamas? Without having a powerful meaning, the destination is letting the traveler decide by default, and that default is often decided simply on cost. Not exactly what the destination marketer had hoped. On the other hand, consider the terrific job that the India Tourist Board has done marketing the subcontinent to the European market. It has grabbed and held the idea of India as an exotic destination with intense cultural color and vibrancy. Unfortunately, the "Incredible India" campaign is a diamond in a coal mine. Most destinations lack the consistency and soul of the India juggernaut. The key to success is found in convention and visitors bureaus (CVBs), but it is within those same organizations that the problems are found. A CVB and/or a tourism ministry are uniquely positioned to coordinate and share a common focus. The problem is that often the politics of those organizations water down the message until it is so vanilla that no one is pleased, least of all the tourist. A consumer's choice of a destination is a complicated decision. The prospects have to decide on a region and then answer a set of questions: If I want to go to New England, which state? If I decide to climb the Rockies, where do I go in that range of mountains? The complications extend to choosing their lodging, packages and transportation, all the more reason to make the emotional connection to a destination as simple as possible. Precision, consistency and importance are the hallmarks of success. The challenge for destinations is to be single-minded. Too many want to tell you about all the features they offer, complete with amenities and scenery and local flavor. While those are important, they are not the reasons why destinations are chosen. It's the single-minded, emotional quality that attracts travelers. For example, consider how this is approached in the fast-food category, where McDonald's is the leader. Now you could argue that's because it has the most locations, but actually, Subway has more. No, what makes McDonald's No. 1 is a single-minded focus on "fun." Does McDonald's have the best food? Of course not, especially from a nutritional standpoint. Does it have the cleanest restaurants? Not in my experience. No, the reason McDonald's is the market leader is because it focuses tightly on family fun to attract customers. It's what the McDonald's brand is all about. It's not about product, necessarily, or friendly staff. It's become the fast-food place you go to that will satisfy anyone you are with (most notably, your family). Think how India would market a ski resort. Showing fresh-faced, rosy-cheeked skiers speeding down a snowy trail would not be enough. The brand demands more. India, if it had ski resorts, would market them as being "exotic." I am hard-pressed to think of a ski destination that owns anything other than snow, variety and nightlife. Where is the brand? It resides in the resorts, not the entire destination. I might know what Breckenridge means (even if it is little different from Keystone or Vail), but the skier needs a more prominent touchstone when making the distinction that creates preference. Anything else comes down to weather reports and price. The tropical destination market is even more complex. It includes the cruise industry, the island groups, all-inclusive resorts, amenities like reef diving and access to local culture. Think about this: How are prospective travelers to decide where to spend their money? Is it the island that they choose or the resort where they spend their time? Are they looking for an all-inclusive price for a bar in a pool or are they looking for immersion in a local culture? Or are they seeking both? Why not know your target market's innermost beliefs, gauge their appetite and sell them a fulfillment of that yearning? To do it, you need more than the typical usage and attitudinal study; you need a brand anthropological study that gets right to root behavior by uncovering the highest emotional intensity that drives decisions. Once you align yourself with that intensity, you will become more preferred because you are about the traveler and not about you, the destination. The most effective assistance a resort or a specific location can receive is from its CVB or local tourism organization. That's where the brand should live. The decision tree among travelers is not to seek out a specific resort (unless you're talking about Disney World). Tourists first consider a place, a destination that speaks to their aspirations. Here's a plan for what CVBs should do:
If any destination positions itself with an emotional quality, all its resorts, hotels and restaurants follow suit, and you have a brand that fits into the traveler's decision tree. You need to get the traveler to seek you out and beat a path to your door even if the costs are greater -- that is, unless you want to compete only on price and category. But the fact is that those funding the marketing budgets are hoping for more. Tom Dougherty is the CEO and president of branding company Stealing Share. Over a 25-year career, he has led efforts for such brands as Ikea, Tide and Lexus as well as for many destinations.
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The family cabins, a first for Holland America Line, can accommodate five people.
On the third day of CruiseWorld, Norwegian Cruise Line CEO Kevin Sheehan addressed the audience, followed by the President's Panel.
Jaf Travel offers a seven-night trip to Guatemala visiting Guatemala City, Antigua, Chichicastenango, Lake Atitlan and Tikal.
Flo Tours offers an 18-night trip to the South Pacific with two departures in 2015 stopping in Auckland, Waitomo, Rotorua and Queenstown, New Zealand; Sydney, Alice Springs, Ayers Rock, Cairns and Port...
Great Safaris features a land tour in Kenya this winter visiting Nairobi, Samburu, Lake Nakuru and the Masai Mara.
Pacific Delight Tours' China trip spends three nights in Beijing, four nights cruising the Yangtze River, two nights in Xian and three nights in Shanghai.
Flo Tours offers a 13-night trip spending four nights in Azerbaijan, five nights in Georgia and four nights in Armenia with departures in April and October.
The Grand Del Mar in San Diego is offering a pair of Christmas packages, one designed specifically for men and one for women, as well as a plan to ring in the new year.
Through Dec. 14, St. Barth Properties, a company with a portfolio of 190 villas on St. Barth in the French West Indies, is offering the seven-night Drive, Dine & Relax plan at five select villas.
The Fairmont Copley Plaza in Boston created the Suite Soiree package for an evening of celebrating for up to 10 guests in the hotel's Presidential Suite.
Guests at the Summit Lodge Boutique Hotel in Whistler, British Columbia, can escape the chaos of the holiday season with the Big Catch ice-fishing package.
Emerald Waterways' nine-night Enchantment of Eastern Europe voyage sails the Danube River between Budapest and Bucharest, Romania, with three departures in 2015.
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text: AP U.S. History Superstars View full-size image < previous next > Is this photo a winner? "This is this year's AP U.S. History class. They are all dressed in the own official APUSH atire with the class roster and their favorite quote from the famous president Theodore Roosevelt. All of these students finished out the year with a stellar grade and earned their place on Sanwan Hill with the victorious Rough Riders" - Mr. History (Jun 02, 2014) Share this photo on: Twitter Facebook Pinterest Similar Photos: apush | theodore roosevelt | WE'RE DONE! | k12 | k-12 | academics nhs | ap us history class Feeling inspired? Visit the CustomInk Design Lab to start your own group order. Design Your Own

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Originally published November 19, 2012 at 4:55 PM | Page modified November 20, 2012 at 3:54 PM
Heavy snow from recent storms opening some Washington ski resorts
Recent storms have piled up snow at ski resorts. Stevens Pass will open Tuesday, with Mount Baker and Crystal Mountain planning on Wednesday openings. Mission Ridge will open on Friday.
Seattle Times staff reporter
More snow sports
New lodges, lifts and more at our region's ski resorts
Mom-and-pop ski areas bring powder to the people
Cross-country skiing and more snow play around Washington
Compare lift prices for this winter
Swooping down the ski slopes just a half-hour from Vancouver, B.C.
Go ice skating in the Methow sun
The stormy weather that has pounded the region the past few days has been good news for ski resorts.
Stevens will be open Tuesday from noon to 4 p.m., and Wednesday from 9 a.m. to 4 p.m. with the Brooks and Daisy chairlifts in operation. Lift tickets will be $20. Early-season conditions exist so skiers and snowboarders should use caution.
On Sunday night, 14 to 18 inches of new snow fell, bringing the base total to about 24 inches and 31 on top with more snowfall in the forecast.
Crystal Mountain Resort will be open from 9 a.m. to 4 p.m. Wednesday and Thursday with the Gondola, Green Valley and Rainier Express lifts operating. Much of the open areas are intermediate and expert terrain. Crystal plans to open Chinook and Forest Queen lifts by Friday, and possibly High Campbell for access to Powder Bowl on Friday, as well. Lift tickets will cost $45 on Wednesday.
The base at Crystal is 20 inches and the summit has a depth of 40 inches, with 15 inches of new snow falling last night.
Mount Baker will have limited operations beginning at 9 a.m. Wednesday from the Heather Meadows area.
A warm front is expected to cause the freezing level to rise above 5,000 feet, but a cold front will bring much colder temperatures and more snow by late Tuesday and Wednesday, with 6 to 12 inches of new snow.
Mission Ridge will open Friday with Chairs 1 and 2 operating, and depending on snow conditions Chair 3 could also be up and running. Lift tickets will be $40. Check www.missionridge.comfor operating hours later this week.
• Western Washington's Marlayna Geary has been chosen as the Great Northwest Athletic Conference volleyball Player of the Year. Teammate Samantha Hutchinson was picked as Defensive Player of the Year and WWU's Diane Flick was picked as the GNAC Coach of the Year.
Also chosen to the first team were Seattle Pacific's Cailin Fellows and Shelby Swanson, Western's Kayla Erickson and Laurie Yearout and Central's Marcy Hjellum and Erin Smith.
• Shannon Ellis, coach of the Seattle University volleyball team for the past nine seasons, has announced that she is leaving the program to focus on her family.
• Megan Lindsay of SPU, Western's Jamie Arthurs, Kristin Maris and Brina Sych were selected to the Daktronics West Region all-star soccer team.
SID departments contributed to this report.
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PLONING screening with FOR YOUR CONSIDERATION Oscar program
The Philippine's official entry for the Academy Award for Best Foreign Language Film, PLONING, starring Judy Ann Santos will be screening at the San Rafael Film Center on January 18, 2009.
The Philippine's official entry for the Academy Award for Best Foreign Language Film, PLONING, starring Judy Ann Santos will be screening at the San Rafael Film Center on January 18, 2009.
The Bay Area has long been fertile ground for extraordinary work in documentary filmmaking. The San Rafael Film Center will be showcasing the nominees on January 11, 2009
The Tribeca Film Institute Sloan Filmmaker Fund is seeking feature length narrative works that dramatize stories about science, technology, mathematics or medicine, as well as celebrated personalities in these fields.
Johnnie To's SPARROW is a love letter to Hong Kong with intricately choreographed scenes and a 60's Euro-cool soundtrack full of marimba glissandos and sparkling jazz pianos. SPARROW opens a the 4 Star Theatre on December 25th.
Misa reviews Clint Eastwood's latest creation "Gran Torino," in which Eastwood plays an aging white resident in a neighborhood now populated by Hmong families.
Last month, something happened which reminded me that I'm not just making a film. In documentary, we're not just dealing with footage that we shot a few months ago; we're dealing with individuals whose lives continue evolve. This is real life, and sometimes things change for the better, sometimes for the worse. In this case, it was definitely the latter…
December 10th is Human Rights day, and in celebration the 1000 Voices, a really interesting archive of a different American stories, has highlighted videos in their collection that feature folks working in the Human Rights movement. Check out some of the videos.
In THE LAST GHOST OF WAR, we meet victims who are plaintiffs in a class action suit against 32 U.S. chemical companies. These Vietnamese victims are seeking compensation and justice. The question is were these dioxin-laden herbicides chemical weapons? And if so, who should be held accountable in the wake of what was arguably the largest chemical warfare operation in history?
Join our facebook page and WIN an 8GB ipod nano.That's it! The winner will be randomly selected from our fans on facebook, January 5, 2009 by noon.
On February 12th and 13th in Washington DC, The Center for Social Media invites established as well as aspiring filmmakers, non-profit communications leaders, funders, and students to our fifth annual Making Your Media Matter conference where we will explore the theme: Ethics, Money and Mission.


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Young leaders emerging from Ferguson movement
Nov 22, 2014 • STLtoday.comShe is a graduate of John Burroughs School and Washington University. She has said she plans to continue to protest as she serves on the commission. "We have the power to end this ... He graduated from Sumner High School, a high-poverty, low-performing ... More
Liberty Bell girls soccer heads to state
Nov 20, 2014 • Omak Okanogan County Chronicle#SUMNER – Liberty Bell takes on Friday Harbor in one of two state 1B/2B semifinal girls soccer matches Friday at Sunset Chev Stadium at Sumner High School. #The Mountain Lions (16-4) play at 4 p.m. against the Wolverines (14-5), which are making their ... More
Ferguson protest leaders come from varied backgrounds but with a common ...
Nov 23, 2014 • Reading EagleShe is a graduate of John Burroughs School and Washington University. She has said she plans to continue to protest as she serves on the commission. "We have the power to end this cycle and ... He graduated from Sumner High School, a high-poverty, low ... More
Hundreds of South Sound teens get first-hand look at hard-hat careers
Nov 13, 2014 • The OlympianTacoma Power lineman Ben Collins lifts Sumner High School's Danica Bare and Jeremy Nusse in a 105-foot-high line bucket truck during Career Day at the Puyallup Fairgrounds on Thursday, Nov. 13, 2014. More than 2,000 high school students from Pierce ... More
Wolverines seal first-ever win at State in shutout, clinch semi-final berth ...
Nov 17, 2014 • Journal of the San Juan IslandsThat would be the last opportunity for Brewster and the Wolverines were able to celebrate advancing to a final four matchup Friday, Nov. 21. They will travel to Sunset Chevrolet Stadium at Sumner High School for a 4 p.m. showdown with Liberty Bell (16 ... More
Sumner High students compete at White House Science Fair
May 27, 2014 • MyNorthwest.comAnd this year, the president is honoring girls excelling in science technology, engineering and math (STEM). Two of those girls are sophomores from Sumner High School. "I'm really nervous because I've never been to Washington, D.C. before," says Celine ... More
Sumner takes control in SPSL 3a girls soccer
Oct 22, 2014 • The Seattle TimesSUMNER – The Sumner High School girls soccer team has relied heavily on its six seniors, winning a pair of Class 2A state titles in the group's four years. So it was an ironic twist that the team's young talent lifted the experienced group in a time of ... More
Sumner girls fall in regionals for second straight year
Mar 1, 2014 • TheNewsTribune.comThe Sumner High School girls basketball team racked up 14 consecutive wins, going the entire month of January without a loss, and claimed the 2A South Puget Sound League regular-season title. It's little wonder Lake Washington's Sydney Shepard ... More
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Description: Mike Mitchell, member of Stanley Clarke trio at Toronto Jazz Festival on Nathan Phillips Square in June, 2014.
Lil Mike has a really quick hands and obvious talent.
toronto drums toronto jazz festival stanley clarke bw june b w mike mitchell blaque dynamite
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In addition to producing such feature length films as The General and The Navigator, Buster Keaton produced a number of shorter films of fine quality of which Balloon antics is an excellent example. Notable points about this film include the wonderful use of natural scenery, the high degree of ... Read more
A silhouette fantasy based on themes from Mozart's opera "The Magic Flute." A unique method, falling half &ndash: way between the drawn cartoon and the puppet film. ... Read more
The film shows the various forms of attack and defence as practised by judo experts, including Professor Mifune, at the world head ... quarters of judo, the Kadokan Academy in Tokio. ... Read more
Animated film on the establishment of the U.S. Federal Government and the formulation of the Constitution and Bill of Rights. ... Read more


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Are you looking to pick up a new MMO but not sure which one to try? Or perhaps you're one of those people that simply doesn't get all the hullabaloo surrounding World of Warcraft. If you happen to be just this type of person, then Howstuffworks has the article for you. "How World of Warcraft Works" looks into the game from an outsider's perspective, and gives a brilliant overview of nearly every aspect of the game.
From player base to the guts behind the game, the article goes over the parts of the WoW phenomenon, including several references to our beloved NickYee of the Daedalus Project and his demographic research on WoW players. Granted a lot of the information may be basic, but I found that even as an avid WoW fan I learned some things I didn't know, or had at least temporarily forgotten. And really, it's great to see so much information about the game condensed into its simplest form.
No comments yet. :(
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TERA's Fate of Arun expansion is coming December 16th
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Posted on Nov 23rd 2014 12:00PM


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NASTC head David Owen's sleep apnea story
NASTC president David Owen is firm in his belief in a professional driver's ability to manage fatigue. And while he clearly knows the benefit of apnea treatment in those who suffer from it, Owen cites ...
Sleep apnea and conditional medical certification being fought on new fronts
In an attempt to solve the problem of medical examiners' willingness to issue short-term conditional certifications — if any certification at all — pending results of a sleep study, NASTC has started offering both member ...
Can an employer fire or refuse to hire me on account of a sleep apnea diagnosis?
Following the 2008 amendment of the Americans with Disabilities Act, employers must make reasonable accommodations for drivers with sleep apnea, says Truckers for a Cause cofounder and driver Bob Stanton.
OOIDA's new NCRME survey; Benefits of apnea treatment for one operator
Independent owner-operator Joe Bielucki's sleep apnea story -- results following his preemptive strike of sorts relative to the condition two years ago.
How to address sleep apnea risk
On your terms.... And what to expect for treatment if you are diagnosed.
Guilty until proven innocent: Answering key sleep-apnea questions
As new medical certification processes come into play, more drivers are being asked to get sleep apnea testing. Some are asking questions, getting varied answers – and being taken off the road prematurely.
Have you ever been tested/treated for sleep apnea?
This poll looks at incidence of apnea testing and treatment -- have you been tested or treated recently or in the past, whether as a result of a DOT physical or a regular doctor visit? ...
POLL: Has your most recent DOT physical resulted in a sleep apnea test?
With no official regulation or guidance on testing for the sleep apnea condition in the rulebooks, practices vary around the nation -- some say apnea testing is on the rise. Tell us your recent med ...
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What are your stories about adopting with birth children?(25 Posts)
FamiliesShareGerms Thu 05-Sep-13 07:08:28
Meita Wed 28-Aug-13 09:19:27
jamiesndryliesmammy Wed 28-Aug-13 04:26:12
Italiangreyhound Tue 27-Aug-13 23:41:04
KristinaM Tue 27-Aug-13 23:22:11
parasaurolophus Tue 27-Aug-13 14:45:09
2ndtimeround Sat 01-Jun-13 20:03:46
Italiangreyhound Thu 30-May-13 16:54:21
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parasaurolophus Thu 30-May-13 09:35:25
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aladdinsane Sun 26-May-13 18:35:34
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Say you ignored one of those "this website is not trusted" warnings and it led to your computer being hacked. How would you react? Would you: A. Quickly shut down your computer? B. Yank out the cables? C. Scream in cyber terror? For a group of college students participating in a research experiment, all [...]
Security Risk: We Ignore Online Warnings
Thin Film Produces New Chemistry in 'Nanoreactor'
Physicists at the University of Groningen led by Professor of Functional Nanomaterials Beatriz Noheda have discovered a new manganese compound that is produced by tension in the crystal structure of terbium manganese oxide. The technique they used to create this new material could open the way to new nanoscale circuits. Their findings were published on [...]
A 3D, Talking Map for the Blind (And Everyone)
These maps are made for talking. And touching. And they're beautiful, too. Touch-responsive maps bring interactive wayfinding to a new level, providing independence to the visually impaired. In partnership with Touch Graphics Inc., developers at the University at Buffalo's Center for Inclusive Design and Environmental Access (IDeA Center) have built and tested a new [...]
Engineers Efficiently 'Mix' Light at Nanoscale
The race to make computer components smaller and faster and use less power is pushing the limits of the properties of electrons in a material. Photonic systems could eventually replace electronic ones, but the fundamentals of computation, mixing two inputs into a single output, currently require too much space and power when done with light. [...]
Magic Tricks Created Using Artificial Intelligence for the First Time
Researchers working on artificial intelligence at Queen Mary University of London have taught a computer to create magic tricks. The researchers gave a computer program the outline of how a magic jigsaw puzzle and a mind reading card trick work, as well the results of experiments into how humans understand magic tricks, and the [...]
Self-Repairing Software Tackles Malware
University of Utah computer scientists have developed software that not only detects and eradicates never-before-seen viruses and other malware, but also automatically repairs damage caused by them. The software then prevents the invader from ever infecting the computer again. A3 is a software suite that works with a virtual machine — a virtual computer [...]
Virtual Reality Speeds Up Rehabilitation
The Hong Kong Polytechnic University has successfully developed a novel training programme using haptic technology for impaired hands that cannot function normally. This programme is unique as it provides force feedback, which creates a true sense of weight to the user through the control device. Our hands are essential to our lives; we need [...]
Printing Self-Learning Robots With 3D Printers
On the third floor of the Department of Informatics there is a robotics laboratory which looks like a playroom This is where researchers are testing how their robots can figure out how to move past barriers and other obstacles. "In the future, robots must be able to solve tasks in deep mines on distant [...]
Telecommunications: New Radio Wave Device
Researchers at the Cockrell School of Engineering at The University of Texas at Austin have achieved a milestone in modern wireless and cellular telecommunications, creating a radically smaller, more efficient radio wave circulator that could be used in cellphones and other wireless devices, as reported in the latest issue of Nature Physics. The new [...]
New Technique for Generating Electricity
Research scientists at VTT Technical Research Centre of Finland have demonstrated a new technique for generating electrical energy. The new method can be used in harvesting energy from mechanical vibrations of the environment and converting it into electricity. Energy harvesters are needed, for example, in wireless self-powered sensors and medical implants, where they could ultimately [...]
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Just wondering what pcs u guys play the game on, and how well it plays. Just tell me your specs, the quality and resolution u play, and if it works well.
Just wondering what pcs u guys play the game on, and how well it plays. Just tell me your specs, the quality and resolution u play, and if it works well.
A pretty old Toshiba laptop with a Nvidia Go 7900GS graphics chip, Win7 RC1, 1.7Ghz DualCore, 2GB of RAM.
I'm playing at 1680x1050, quality 1. Although it has to be said that I
1. Am more interested in smooth motion (40fps or more) than in graphical effects.
2. Am playing on a stereo monitor, so my system is actually rendering twice the number of frames: One for the each eye.
I have currently been playing it on an Athlon64 X2 3800+ (OC'ed to 2.8Ghz though) with an nvidia 9800GT at 1680x1050. This is all under Linux as well through Wine, and it plays beautifully.
I also tried it on my laptop which has a Turion X2 ZM-82 CPU (2.2Ghz) with an ATI Readon 3850 GPU. That was played on Vista with 1680x1050 resolution and all of the anti-aliasing settings turned up. It played just as fine on that one as well.
Both machines had the quality turned up all of the way in the game settings.
The game isn't very demanding (as far as I can tell) so you should be able to play it on half way decent hardware. They do some fancier things such as field of depth (fuzzy edges on close up/far away objects) so that will make it take a little more power than Sam & Max though for example.
Well my pc:
-DualCore 2140
-1g of ram
-NVDIA 6200 (256m)
-Windows XP (SP2)
Old but it runs the game without problem.
I play it on a 1024x768 resolution and at graphic level 4. Over than 4 there are some issues with the lip-sinc and the voices (they start following different ways at that point) so i stick at 4.
- Quad Core Q9650 @ 3.0GHz
- ATI Radeon HD 4870x2 (2GB RAM)
- Vista Home Premium 64-bit
I have the graphics settings cranked all the way up and run at the max resolution for my monitor (1440x900), and my system doesn't even break a sweat.
I should download it onto my old laptop (P4 @ 3Ghz, ATI Mobility Radeon X600, 2GB RAM, Windows XP) and see how it runs there. My guess is not so well. ;)
Dell Precision M4400
Linux (Ubuntu Karmic x64) / wine 1.2.28
nVidia FX700m on nVidia proprietary graphics driver v185
Intel Core Duo P8600 @ 2,4Ghz
Plays beautifully at 1440x900 (native resolution) on setting 9.
Q6600 Quadcore at 2.4ghz (Stillll haven't overclocked it)
4 gig 1066mhz RAM
Geforce 9800gt 1 gig
Works perfectly at 9 in 1440x900.
Phenom X4 9450 with DDR2 and a GeForce 8800GT running Kubuntu Linux 9.10. I run Tales inside VMWare with a WinXP 1GB RAM, dual core guest. Game runs at 1440x900. Works like a charm since VMWare Workstation 6.5.3.
I have Vista as a boot alternative but why reboot if you don't have too...
AMD Athlon 64X2 4400+ 2.3 Ghz, 4 GB RAM, 896MB Geforce GTX275 OC edition, and Windows Vista Home Premium is my main system.
I sometimes play stuff on my laptop which has an AMD Turion 64X2 2.2 Ghz, 3 GB RAM, Geforce 8200M, and also Vista Home Premium.
Both will be getting Windows 7 once it's out, however.
I've got a cruddy Nvidia 9500GT, 4GB ram and 2.6ghz quadcore, and it can run TOMI at max without any issues.


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Product Description
Scientific Name: Spinacea oleracea
Amount in pack: 250± seeds
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I sent special interrogatories and requests for admission to defendants. They responded with objections only. I know that in order for me to compel further responses I need to meet and confer with the defendant's attorney.
Can I contact him by email and request a meeting? Also, for this meeting, am I obligated to go to his office or can I request him to meet in the middle of way between us for example in a public library (since I don't have an office) and can I conduct this meeting over the phone rather than meeting in person? Is there a specific protocol to follow during this meeting or is it just an open conversation? Can they or me record this conversation?
Most judges will tell you that a meaningful meet and confer requires either meeting in person or having a telephone conference, not just sending and exchanging letters or emails.
However, before having an in person meeting or telephone conference, it is often useful to first write a meet and confer letter setting forth why you believe the responses are inadequate and/or objections are without merit.
An in person meeting can be conducted anywhere. There isn't a specific protocol.
You do not need to meet and confer in person. You can do it over the phone or, my preference, in writing. Send a letter setting forth all of the reasons why the responses are unacceptable, provide legal authority for your position and request further responses by a date certain – give them one week. If they want more time, confirm that you also have an extension of time in which to file your motion to compel.
You need an attorney to help you.
Best of luck to you.
Attorney Rebekah Ryan Main
If you found this answer helpful, let me know by clicking the "Mark as Helpful" button at the bottom of this answer. It's easy and appreciated.
This response is intended to be a general statement of law, should not be relied upon as legal advice, does not create an attorney/client relationship and does not create a right to continuing email exchanges. We can be visited on the web at www.Main-Law.com or call 909-891-0906.
Q. Is there a specific protocol to follow during this meeting or is it just an open conversation?
A. Just a conversation; or, an exchange of emails or letters. No protocols. Whatever you/they say will come up in the next round. Be fir,. but be reasonable. Be clear. Back up your assertions with references to the law of discovery, either statutes or cases, if possible.
Q. Can they or me record this conversation?
A. Anyone can record any conversation if the other side consents. In the absence of consent, not a good idea. Surreptitious recording of a phone call is a crime in CA, and could result in hefty fines. Again, good to write a letter or email. if you think a record will be important No expectation of privacy there, no problem attaching the email/letter exchange as an exhibit to a subsequent motion to compel.
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Events for July 8, 2013
Chicago Farmers' Markets
When: From 05/12/2013 to 10/31/2013
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Chicago Cubs at Brewers
When: From 06/25/2013 to 09/19/2013
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Are you Tomoyuki Hanaoka?Claim your profile
Publications (69)209.55 Total impact
Article: Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China.[Show abstract] [Hide abstract]
ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs. Subjects were 57 workers and 20 controls. Level of personal exposure to PAHs was measured using GC-MS. In accordance with the assessment methods defined by the United States Environmental Protection Agency (US EPA), 15 PAHs were selected for the analysis. For the measurement of urinary metabolites, urine samples were treated with β-glucuronidase and analyzed using HPLC with a fluorescence detector. The mean range of personal exposure to 15 PAHs (total PAHs) was 178.85, 47.08-1,329.45 (geometric mean, 5th and 95th percentile) μg/m(3). Ten known urinary metabolites (1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenz[a]anthracene, 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene) and four unknown peaks were detected. The highest correlation was between total PAHs and urinary 2-hydroxynaphthalene (Spearman r = 0.716, P < 0.01). Among the detected urinary metabolites, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, and 1-hydroxypyrene were found to correlate significantly with the "Σ carcinogenic potency of PAHs" (sum of seven carcinogenic PAHs calculated from the levels of personal PAHs and relative potency factors), and with the greatest correlation found for 1-hydroxypyrene (Spearman r = 0.630, P < 0.01). The analysis of personal exposure to 15 PAHs and 10 urinary metabolites, and calculation of Σ carcinogenic potency, indicated that urinary 1-hydroxypyrene was the most comprehensive carcinogenic biomarker of exposure to PAHs.International Archives of Occupational and Environmental Health 10/2013; · 2.10 Impact Factor
Article: Associations between hazard indices of di-n-butylphthalate and di-2-ethylhexylphthalate exposure and serum reproductive hormone levels among occupationally exposed and unexposed Chinese men.[Show abstract] [Hide abstract]
ABSTRACT: The knowledge on the dose-response relationships between cumulative phthalate exposure and reproductive hormones in human are lacking. To assess the characteristics of the associations between hazard index (HI) of cumulative di-n-butylphthalate (DBP) and di-2-ethylhexylphthalate (DEHP) exposures and serum concentrations of free testosterone (fT), estradiol, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), we used restricted cubic spline function to characterize the dose-response curves between the HI values and reproductive hormones for 74 male workers occupationally exposed to high levels of DBP and DEHP, and 63 male construction workers as comparison group matched for age and smoking status. The median of HI value was 5.30 for exposed workers, 53.0-fold that of unexposed workers (0.10). 89.2% of exposed workers and 1.6% of unexposed workers have HI over 1.00. We observed a borderline significantly negative association between HI and fT in exposed workers (r=-0.195, p=0.096), but not in unexposed workers. The exposed workers showed inverted long-tailed J-shaped fT and FSH curves, and small changes in the LH curve, whereas unexposed workers had inverted and flattened-S-shaped fT and mirror-S-shaped LH and FSH curves. Both T production and hypothalamo-pituitary-testis (HPT) axis function were damaged in workers with high HI of phthalate exposures. HPT feedback function was activated in workers with both high and low HI, and plays an important role in preventing fT level from further decreasing with a rise in HI.International Journal of Andrology 07/2011; 34(5 Pt 2):e397-406. · 3.37 Impact Factor
Article: Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.[Show abstract] [Hide abstract]
ABSTRACT: We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk.Nutrition and Cancer 01/2010; 62(4):466-75. · 2.70 Impact Factor
Article: Survival prognosis of Japanese with severe motor and intellectual disabilities living in public and private institutions between 1961 and 2003.[Show abstract] [Hide abstract]
ABSTRACT: Although the prognosis for survival in people with severe functional disabilities is a serious concern for their families and health care practitioners, there have been few reports on survival rates for this population. Every year, the Japanese Association of Welfare for Persons with Severe Motor and Intellectual Disability collects anonymous records of individual registrations and deaths from all private and public institutions, excepting national institutions. We used these data to estimate the prognosis for survival. We reviewed the records of 3221 people with severe motor and intellectual disabilities (SMID); all subjects had lived in one of 119 public or private institutions in Japan between 1961 and 2003. Kaplan-Meier survival estimates were calculated according to disability type and birth year range. Of the 3221 persons, 2645 were alive and 576 had died. The survival rate at the age of 20 for all subjects was 79% (95% confidence interval, 78%-81%). Among people who were unable to sit, those with lower intelligence quotients had lower survival rates. The survival rate among people with SMID housed in public and private institutions in Japan was much worse than that of the general population, and has not improved since the 1960s.Journal of Epidemiology 11/2009; 20(1):77-81. · 2.11 Impact Factor
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ABSTRACT: Phthalates may act as an estrogen and are a potential risk factor for estrogen-related diseases such as endometriosis. We assessed the association between phthalate exposure and endometriosis in 166 consecutive women who presented at a university hospital for consultation regarding infertility. The subjects were interviewed and provided a urine specimen prior to a laparoscopic diagnosis of endometriosis. They were then categorized by the severity of endometriosis as controls (stages 0-I) and cases (stages II-IV). Urinary concentrations of the phthalate metabolites monoethyl phthalate, mono-n-butyl phthalate, monobenzyl phthalate, mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-oxohexyl) phthalate, and mono(2-ethyl-5-hydroxyhexyl) phthalate were measured in 57 cases and 80 controls using high-performance liquid chromatography isotope-dilution tandem mass spectrometry. Adjusted odds ratios for endometriosis in relation to dichotomized individual phthalate metabolites (standardized for creatinine) were calculated. No significant association between endometriosis and any urinary creatinine-adjusted phthalate monoester was seen. Adjusted odds ratio (95% confidence interval) for higher dichotomized MEHP by endometriosis was 1.57 (0.74-3.30). No monotonic trend was seen in urinary creatinine-adjusted concentration of phthalate metabolites by endometriosis stage (p=0.23-0.90). Our results do not support the hypothesis that higher urinary concentrations of phthalate metabolites are associated with the risk of endometriosis in infertile Japanese women.Science of The Total Environment 10/2009; 408(1):37-42. · 3.16 Impact Factor
Article: Dietary isoflavone intake and breast cancer risk in case–control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians[Show abstract] [Hide abstract]
ABSTRACT: Although epidemiologic studies have shown an inverse association between isoflavones and breast cancer risk, little evidence for a dose–response relation is available. We conducted hospital-based case–control studies of patients aged 20–74years with primary, incident, histologically confirmed invasive breast cancer, and matched controls from medical checkup examinees in Nagano, Japan and from cancer-free patients in São Paulo, Brazil. A total of 850 pairs (390 Japanese, 81 Japanese Brazilians and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. The odds ratio of breast cancer according to isoflavone intake was estimated using a conditional logistic regression model. We found a statistically significant inverse association between isoflavone intake and the risk of breast cancer for Japanese Brazilians and non-Japanese Brazilians. For Japanese, a non-significant inverse association was limited to postmenopausal women. In the three populations combined, breast cancer risk linearly decreased from 'no' to 'moderate' isoflavone intake and thereafter leveled off. Compared to non-consumers, adjusted odds ratios (95% confidence interval) for consumers in increasing quintile intake categories (median intake in each category: 8.7, 23.1, 33.8, 45.7, and 71.3mg/day) were 0.69 (0.44–1.09), 0.54 (0.31–0.94), 0.45 (0.26–0.77), 0.34 (0.19–0.62), and 0.43 (0.24–0.76), respectively. Overall, we found an inverse association between dietary isoflavone intake and risk of breast cancer. Our finding suggests a risk-reducing rather than risk-enhancing effect of isoflavones on breast cancer within the range achievable from dietary intake alone. In addition, women may benefit from risk reduction if they consume at least moderate amounts of isoflavones.Breast Cancer Research and Treatment 07/2009; 116(2):401-411. · 4.47 Impact Factor
Article: Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.[Show abstract] [Hide abstract]
ABSTRACT: Epidemiologic studies have shown an inverse association between isoflavones and breast cancer risk. Because isoflavones bind estrogen receptors, we hypothesized that polymorphisms in the estrogen receptor genes might modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based case-control studies of patients aged 20-74 years with primary, incident, histologically confirmed invasive breast cancer, and matched controls from among medical checkup examinees in Nagano, Japan, and from cancer-free patients in São Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians and 379 non-Japanese Brazilians) completed validated food frequency questionnaires, and provided blood samples. Five single nucleotide polymorphisms in the estrogen receptor alpha (rs9340799, rs1913474, and rs2234693) and beta (rs4986938 and rs1256049) genes were genotyped. We found no consistent association between the five single nucleotide polymorphisms and breast cancer risk among the three populations. In analyses of combinations of isoflavone intake and single nucleotide polymorphisms, an inverse association between intake and risk was limited to women with the GG genotype of the rs4986938 polymorphism for postmenopausal Japanese (odds ratio for highest versus lowest tertile = 0.47; P for trend = 0.01), Japanese Brazilians (odds ratio for highest versus lowest median = 0.31) and non-Japanese Brazilians (odds ratio for consumers versus non-consumers = 0.37) (P for interaction = 0.11, 0.08, and 0.21, respectively). We found no remarkable difference for the other four polymorphisms. Our findings suggest that polymorphisms in the estrogen receptor beta gene may modify the association between isoflavone intake and breast cancer risk.Cancer Science 03/2009; 100(5):927-33. · 3.48 Impact Factor
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ABSTRACT: Most epidemiological studies of the association between breast cancer risk and exposure to organochlorine pesticides or polychlorinated biphenyls (PCBs), which are suspected endocrine disrupters and potential risk factors for human breast cancer, have been conducted in western countries, and the majority of results have been null and the rest inconsistent. Here, we examined these associations in Japanese women in the largest study in Asian women to date. The study was a matched case-control study of breast cancer with 403 eligible matched pairs from May 2001 to September 2005 at four hospitals in Nagano Prefecture, Japan. Serum samples were measured for PCBs and nine pesticide-related organochlorines, including dichlorodiphenyltrichloroethane (DDT). Odds ratios of breast cancer or its hormone-receptor-defined subtypes according to serum organochlorines were calculated. No increase in the risk of breast cancer was seen among women with higher serum concentrations of any organochlorine: o,p'-DDT, p,p'-DDT, p,p'-dichlorodiphenyldichloroethylene, hexachlorobenzene, beta-hexachlorocyclohexane, trans-nonachlor, cis-nonachlor, oxychlordane, mirex, or PCBs. Rather, higher serum levels of cis-nonachlor, mirex, or total PCBs were associated with a decreased risk of breast cancer Overall, these results suggest that breast cancer risk in Japan, a low-incidence country, is similar to that in western countries in terms of organochlorine exposure.Cancer Causes and Control 12/2008; 20(5):567-80. · 3.20 Impact Factor
Article: A case-control study of the association between urinary cadmium concentration and endometriosis in infertile Japanese women.[Show abstract] [Hide abstract]
ABSTRACT: Cadmium may act like an estrogen and be a potential risk factor for estrogen-related diseases such as breast cancer and endometriosis. Here, we tested the hypothesis that higher cadmium exposure is associated with endometriosis among infertile Japanese women in a hospital-based case-control study. We recruited consecutive female patients aged 20-45 years who had complained of infertility and presented to a university hospital in Tokyo. The subjects were interviewed and provided a urine sample prior to a laparoscopic diagnosis of endometriosis between January 2000 and December 2001. The severity of endometriosis was then dichotomized into controls (stage 0 and I) and cases (stage II-IV). We finally measured urinary total cadmium concentration in 54 cases and 74 controls as a biomarker of long-term cumulative exposure. Odds ratios were adjusted for average menstrual cycle length, body-mass index and smoking status using unconditional logistic regression. Results showed no association between endometriosis and urinary cadmium concentration. Medians (interquartile ranges) of urinary cadmium concentration in cases and controls were 0.53 (0.40-0.73) and 0.54 (0.34-0.76) microg/g creatinine, respectively (P for difference=0.88). Adjusted odds ratio (95% confidence interval) for the highest versus lowest tertile of urinary creatinine-adjusted cadmium concentration was 0.86 (0.30 to 2.49, P for trend=0.79). Our results do not support the hypothesis that higher urinary cadmium concentration is associated with the risk of endometriosis.Science of The Total Environment 07/2008; 402(2-3):171-5. · 3.16 Impact Factor
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ABSTRACT: A c. -285C >A single nucleotide polymorphism (SNP) in the promoter region of the E-cadherin (CDH1) gene, which is a tumor suppressor in gastric cancer (GC), has been shown to decrease gene transcription, but GC case-control studies of this SNP have yielded controversial results. A haplotype study in an Italian population showed that haplotypes based on three SNPs, including the c. -285C >A, are associated with susceptibility to GC. Hence, the purpose of the present study was to carry out a more comprehensive genetic analysis of CDH1 using haplotype-tagging SNPs (htSNPs) in a Japanese case-control study to identify the CDH1 haplotype associated with susceptibility to GC in a Japanese population. First, 11 SNPs in the CDH1 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 30 healthy individuals. Haplotype frequencies were estimated with the expectation-maximization algorithm, and 7 common haplotypes of the CDH1 gene whose frequency was at least 3.3% were identified. Next, 5 htSNPs (c. -285C >A, c.48+6T >C, c.164 -3159T >C, c.2076C >T, and c.2296 -616G >C) were genotyped in a hospital-based case-control study of 148 GC patients and 292 age- and gender-matched healthy controls, and haplotype frequencies based on the 5 htSNPs were estimated. Although none of the 5 htSNPs was related to an overall risk of GC, frequencies of the ATCTG and CTTTG haplotypes were significantly higher and lower, respectively, in the GC cases than in the controls (p<0.05). These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population.Scandinavian Journal of Gastroenterology 01/2008; 42(12):1479-85. · 2.33 Impact Factor
Article: Application of the adductome approach to assess intertissue DNA damage variations in human lung and esophagus.[Show abstract] [Hide abstract]
ABSTRACT: Methods for determining the differential susceptibility of human organs to DNA damage have not yet been explored to any large extent due to technical constraints. The development of comprehensive analytical approaches by which to detect intertissue variations in DNA damage susceptibility may advance our understanding of the roles of DNA adducts in cancer etiology and as exposure biomarkers at least. A strategy designed for the detection and comparison of multiple DNA adducts from different tissue samples was applied to assess esophageal and peripherally- and centrally-located lung tissue DNA obtained from the same person. This adductome approach utilized LC/ESI-MS/MS analysis methods designed to detect the neutral loss of 2'-deoxyribose from positively ionized 2'-deoxynucleoside adducts transmitting the [M+H](+)>[M+H-116](+) transition over 374 transitions. In the final analyses, adductome maps were produced which facilitated the visualization of putative DNA adducts and their relative levels of occurrence and allowed for comprehensive comparisons between samples, including a calf thymus DNA negative control. The largest putative adducts were distributed similarly across the samples, however, differences in the relative amounts of putative adducts in lung and esophagus tissue were also revealed. The largest-occurring lung tissue DNA putative adducts were 90% similar (n=50), while putative adducts in esophagus tissue DNA were shown to be 80 and 84% similar to central and peripheral lung tissue DNA respectively. Seven DNA adducts, N(2)-ethyl-2'-deoxyguanosine (N(2)-ethyl-dG), 1,N(6)-etheno-2'-deoxyadenosine (varepsilondA), alpha-S- and alpha-R-methyl-gamma-hydroxy-1,N(2)-propano-2'-deoxyguanosine (1,N(2)-PdG(1), 1,N(2)-PdG(2)), 3-(2'-deoxyribosyl)-5,6,7,8-tetrahydro-8-hydroxy-pyrimido[1,2-a]purine-(3H)-one (8-OH-PdG) and the two stereoisomers of 3-(2'-deoxyribosyl)-5,6,7,8-tetrahydro-6-hydroxypyrimido[1,2-a]purine-(3H)-one (6-OH-PdG) were unambiguously detected in all tissue DNA samples by comparison to authentic adduct standards and stable isotope dilution and their identities were matched to putative adducts detected in the adductome maps.Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 12/2007; 625(1-2):83-93. · 3.90 Impact Factor
Article: Urinary bisphenol-A concentration in infertile Japanese women and its association with endometriosis: A cross-sectional study.[Show abstract] [Hide abstract]
ABSTRACT: Bisphenol A (BPA), a raw material commonly used in the manufacture of resins such as polycarbonate and epoxy, is a possible xenoestrogen that is hypothesized to disrupt the human endocrine system. Humans are widely exposed to BPA. We investigated the urinary concentration of BPA in infertile Japanese women and its possible association with endometriosis. We recruited 166 women (aged 20-45) who had complained of infertility and visited a university hospital in Tokyo. The subjects were interviewed and their urine samples were obtained prior to a laparoscopic diagnosis of endometriosis between January 2000 and December 2001. Urinary total BPA concentration in 140 eligible urine samples was then measured using enzymatic deconjugation of glucuronide and sulfate and high-performance liquid chromatography isotope-dilution tandem mass spectrometry. Median (25th-75th percentile) unadjusted and creatinine-adjusted urinary BPA concentrations were 1.6 (0.69-2.8) μg/L and 0.80 (0.45-1.3) μg/g creatinine. No significant monotonic association of endometriosis with urinary BPA concentration was observed. Median urinary BPA concentration in women with stage 0-1 endometriosis (0.74 μg/g creatinine) did not significantly differ from that in those with stage II-IV endometriosis (0.93 μg/g creatinine) (p for difference=0.24). This study, based on a larger number of samples than those in previous studies in Japan and using the most reliable analytical method currently available, showed that urinary concentrations of BPA in women who consulted a physician for infertility were not higher than those in other populations. Moreover, no association between urinary BPA concentration and endometriosis was found in this cross-sectional study.Environmental Health and Preventive Medicine 11/2007; 12(6):258-64.
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ABSTRACT: Helicobacter pylori is a major risk factor for atrophic gastritis and gastric cancer. Various extragastric manifestations of H. pylori infection have also recently been suggested. However, the correlation between H. pylori and colorectal cancer (CRC) is controversial. The aim of this study was to examine the correlation between H. pylori, serum gastrin level, and atrophic gastritis with CRC. Subjects were patients with CRC; controls were participants of a health check-up program that was conducted between October 1998 and March 2002 at four hospitals in Nagano Prefecture. For 121 newly diagnosed CRC cases, two controls matched by age (within 3 years), gender, and residence were randomly selected from the program participants. We conducted questionnaires and obtained blood samples from the cases and their controls. Consequently, the CRC cancer pairs consisted of 113 cases and 226 controls. Neither H. pylori infection nor gastrin level nor atrophic gastritis showed any association with a risk for CRC. However, serologically determined atrophic gastritis demonstrated significant elevation in odds ratios (ORs) for rectal cancer (OR = 3.15, 95% confidence interval; 1.19-8.35). Gastric conditions such as chronic H. pylori infection and atrophic gastritis are unlikely to increase the risk for CRC, although atrophic gastritis may increase the risk of rectal cancer.Helicobacter 09/2007; 12(4):328-32. · 3.51 Impact Factor
Article: Validity of a self-administered food frequency questionnaire in the assessment of heterocyclic amine intake using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) levels in hair.[Show abstract] [Hide abstract]
ABSTRACT: Several case-control studies have reported possible associations between heterocyclic amine (HCA) intake and the risk of cancer. The validity of questionnaires used to assess HCA intake has hardly been examined, however; in particular, no biomarker able to serve as an independent measure of habitual HCA intake has been established. In this study, we examined the validity of HCA intake estimated from a food frequency questionnaire (FFQ) using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) level in hair as a reference method. Study subjects were 20 volunteers (7 men and 13 women) aged 25-57 years residing in Tokyo or neighboring cities in Japan. The subjects completed the FFQ, and gave 3-5g of hair twice at an interval of 1-3 months for use in establishing validity. Results showed that intakes of PhIP, MeIQ, Trp-P-1, and total HCA by the FFQ were significantly correlated with PhIP levels in hair when adjustment was made for melanin content (r=0.47, r=0.50, r=0.55, and r=0.51, respectively). The present study indicates that HCA intake estimated from this FFQ provides a reasonable ranking of individuals to allow the analysis of associations between HCA intake and risk of cancer in large-scale epidemiological studies.Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 06/2007; 630(1-2):14-9. · 3.90 Impact Factor
Article: Effect of soy isoflavones on endometriosis: interaction with estrogen receptor 2 gene polymorphism.[Show abstract] [Hide abstract]
ABSTRACT: Progression of endometriosis is considered estrogen-dependent. Dietary soy isoflavones may affect the risk of endometriosis, and polymorphisms in estrogen receptor genes may modify this association. We examined associations among soy isoflavone intake, estrogen receptor 2 (ESR2) gene polymorphisms and risk of endometriosis. We recruited women age 20-45 years old who had consulted a university hospital for infertility in Tokyo, Japan in 1999 or 2000. A total of 138 eligible women were diagnosed laparoscopically and classified into 3 subgroups: control (no endometriosis), early endometriosis (stage I-II) and advanced endometriosis (stage III-IV). We measured urinary levels of genistein and daidzein as markers for dietary intake of soy isoflavones, and genotyped ESR2 gene RsaI polymorphisms. Higher levels of urinary genistein and daidzein were associated with decreased risk of advanced endometriosis (P for trend = 0.01 and 0.06, respectively) but not early endometriosis. For advanced endometriosis, the adjusted odds ratio for the highest quartile group was 0.21 (95% confidence interval = 0.06-0.76) for genistein and 0.29 (0.08-1.03) for daidzein, when compared with the lowest group. Inverse associations were also noted between urinary isoflavones and the severity of endometriosis (P for trend = 0.01 for genistein and 0.07 for daidzein). For advanced endometriosis, ESR2 gene RsaI polymorphism appeared to modify the effects of genistein (P for interaction = 0.03). Dietary isoflavones may reduce the risk of endometriosis among Japanese women.Epidemiology 06/2007; 18(3):402-8. · 5.74 Impact Factor
Article: Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China.[Show abstract] [Hide abstract]
ABSTRACT: Observations of adverse developmental and reproductive effects in laboratory animals and wildlife have fueled increasing public concern regarding the potential for various chemicals to impair human fertility. Our objective in this study was to assess the effect of occupational exposure to high levels of phthalate esters on the balance of gonadotropin and gonadal hormones including luteinizing hormone, follicle-stimulating hormone, free testosterone (fT), and estradiol. We examined urine and blood samples of 74 male workers at a factory producing unfoamed polyvinyl chloride flooring exposed to di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) and compared them with samples from 63 male workers from a construction company, group matched for age and smoking status. Compared to the unexposed workers, the exposed workers had substantially and significantly elevated concentrations of mono-n-butyl phthalate (MBP; 644.3 vs. 129.6 microg/g creatinine, p < 0.001) and mono-2-ethylhexyl phthalate (MEHP; 565.7 vs. 5.7 microg/g creatinine, p < 0.001). fT was significantly lower (8.4 vs. 9.7 microg/g creatinine, p = 0.019) in exposed workers than in unexposed workers. fT was negatively correlated to MBP (r = -0.25, p = 0.03) and MEHP (r = -0.19, p = 0.095) in the exposed worker group. Regression analyses revealed that fT decreases significantly with increasing total phthalate ester score (the sum of quartiles of MBP and MEHP; r = -0.26, p = 0.002). We observed a modest and significant reduction of serum fT in workers with higher levels of urinary MBP and MEHP compared with unexposed workers.Environmental Health Perspectives 11/2006; 114(11):1643-8. · 7.26 Impact Factor
Article: A retrospective cohort study among iron-steel workers in Anshan, China: exposure assessment.[Show abstract] [Hide abstract]
ABSTRACT: Although adequate assessment of exposure is needed in epidemiological studies among foundry workers, previous studies are often lacking in this aspect. We conducted a retrospective cohort study of a Chinese iron and steel company with a 14-yr follow up during 1980-1993. Exposure assessment was performed for a single job, i.e., the current job for the active worker and the longest job for the retired or deceased worker as of the end of the follow-up, which was allocated as the surrogate of lifetime job and was applied to a job-exposure matrix. Of the 147,062 cohort members, 52,394 males (43%) and 5,291 females (21%) were exposed to any of 15 hazardous factors such as dust, silica, PAHs (polycyclic aromatic hydrocarbons), CO (carbon monoxide) and heat. In 2,104 randomly selected samples, the exposure assessment of exposed workers based on a single job was found to be 12-14% lower than the real situation. This study suggests that the exposure assessment is valuable in evaluating the health effects among the foundry workers, despite some limitations such as underestimation of exposure assessment and the lack of data regarding smoking and drinking habits.Journal of UOEH 10/2006; 28(3):253-63.
Article: Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study.[Show abstract] [Hide abstract]
ABSTRACT: Although accumulating evidence suggests that Helicobacter pylori plays a role in gastric carcinogenesis, the magnitude of the risk remains uncertain. Aim: We aimed to estimate the magnitude of the risk of gastric cancer associated with H. pylori infection by a large case-control study nested within a prospective cohort. Possible effect modification by CagA status, and serum pepsinogen status, as a marker of atrophic gastritis, was also considered to see its effect on developing gastric cancer. Subjects and Subjects (n = 123,576) were followed up from 1990 to 2004; 511 gastric cancer cases matched to 511 controls were used in the analysis. Plasma immunoglobulin G antibody to H. pylori, CagA, and pepsinogen I and II were measured. The adjusted odds ratio (95% confidence interval) of gastric cancer associated with H. pylori infection was 5.1 (3.2-8.0). Assuming all CagA-positive subjects are true H. pylori positives doubled this risk. Atrophic gastritis was also associated with an elevated risk of gastric cancer and the risk increased further with pepsinogen levels. Subjects with pepsinogen levels indicative of severe atrophic gastritis may need careful examination regularly regardless of H. pylori infection. Those who have other pepsinogen levels but who are H. pylori seropositive are likely to benefit from H. pylori eradication therapy. Considering both the cost and the potential for misclassification that may occur using multiple serologic tests, caution is needed in interpreting or extrapolating these findings into a screening strategy.Cancer Epidemiology Biomarkers & Prevention 08/2006; 15(7):1341-7. · 4.56 Impact Factor
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ABSTRACT: Foundry workers have increased mortality and morbidity risks from numerous causes, including various cancers. A retrospective Chinese iron-steel cohort study was conducted to examine the mortality effects of exposure to foundry work. Standardized mortality ratios (SMRs) and standardized rate ratios (SRRs) were calculated to evaluate mortality risks among male workers with exposure to 15 hazardous factors, adjusting for confounders. During 14 years of follow-up, 13,363 of 121,846 male workers died. SMR analysis showed a healthy-worker effect in comparison with the general population. SRR analysis showed increased risks for all causes, all neoplasms, and others among the exposed workers compared with non-exposed blue-collar workers. Combined exposure to polycyclic aromatic hydrocarbons and two or more dusts increased the risks of lung cancer (SRR = 654; 95% CI: 113-3,780) and other malignancies. Foundry work has adverse health effects, including carcinogenic risks.International journal of occupational and environmental health 07/2006; 12(3):193-202. · 1.18 Impact Factor
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ABSTRACT: This study evaluates background serum levels of selected organochlorine compounds among Japanese women of reproductive age and investigates whether lifestyle factors, especially dietary factors, may be associated with these levels. A cross-sectional study was performed on 80 Japanese women, aged 26-43 years, who complained of infertility and were confirmed not to have endometriosis. The serum levels of total toxic equivalency (TEQ), 18 polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs), 4 coplanar polychlorinated biphenyls (cPCBs), 36 ortho-substituted polychlorinated biphenyls (PCBs), and 13 chlorinated pesticides or their metabolites were measured and data were collected on the women's age, residence, occupation, body mass index (BMI), smoking and alcohol habit and 6 dietary intakes (fish, meats, rice, vegetables, fruits and dairy products). The serum median level of total TEQ was 25.1 pg TEQ/g lipid, that of PCDDs/PCDFs/cPCBs was 11.5 pmol/g lipid, that of PCBs was 0.46 nmol/g lipid, and that of total pesticides was 1.32 nmol/g lipid. The serum levels of total TEQ, PCDDs/PCDFs/cPCBs, PCBs and pesticides were positively associated with age (P for trend=0.003, 0.01, 0.005 and 0.01, respectively) and frequent fish consumption (P for trend=0.002, 0.003, 0.0003 and 0.006, respectively). Other lifestyle factors were not associated with serum organochlorine levels. The present study suggests that Japanese women who consume fish frequently in their reproductive period tend to accumulate organochlorines in their bodies.Science of The Total Environment 05/2006; 359(1-3):90-100. · 3.16 Impact Factor
Top Journals
Showa UniversityShinagawa, Tōkyō, Japan
National Cancer Center, Japan
Edo, Tōkyō, Japan
- Research Center for Cancer Prevention and Screening
Jiangsu Provincial Center for Disease Control and PreventionChiang-tu, Jiangsu Sheng, China
University of Occupational and Environmental Health
Kitakyūshū, Fukuoka, Japan
- Department of Environmental Epidemiology
Hamamatsu University School of MedicineHamamatu, Shizuoka, Japan
National Cancer Research InstituteLondinium, England, United Kingdom
Okayama University
Okayama, Okayama, Japan
- Faculty of Pharmaceutical Science
Hospital Santa CruzSan Paulo, São Paulo, Brazil
Institute for Science of LabourEdo, Tōkyō, Japan


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Spokane's prospering electronics retail company, Huppin's Hi-Fi, Photo & Video announced on Monday it plans to add a second store, at 8016 N. Division. (Rendering by John Rovtar Design)
This will mark only the second retail outlet in the 102-year history of the company.
At one time Murray Huppin, the CEO and president of the company, said he considered other options and other locations. Eventually he decided to focus on the growing north Spokane corridor.
The new site is north of the North Division Costco and is a joint retail development with Mark Lax and Joel Huppin, the cousin of Murray Huppin. Lax is owner of Pawn 1, which will use part of the new building for expanded operations. The building will have space for one or more other retail tenants, Huppin said.
The new store will have about 8,000 square feet, said Huppin. The full building will be about 23,000 square feet.
"This store will be the first of its kind in Spokane, and we are excited to offer the next generation of home electronics shopping experience to regional residents," Huppin said in a news release.
The building site is north of the current North Division Pawn 1 store. It was originally used by Magnolia HiFi, then later by Furniture Supercenter.
Along with Including its online OneCall operation and Spokane Valley warehouse, Huppin's employs more than 90 people in Spokane.
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Nashville, United States of America
2425 Atrium Way, Nashville, TN 37214, United States of America – Show map
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Outdoor Pool (seasonal)
Golf Course (within 2 miles)
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WiFi is available in all areas and is free of charge.
Free public parking is available on site (reservation is not needed).
Vending Machine (drinks), Vending Machine (snacks), Airport Shuttle (surcharge), 24-Hour Front Desk, Express Check-in/Check-out, Baggage Storage, Laundry, Dry Cleaning, Meeting/Banquet Facilities, Business Center, Fax/Photocopying, Souvenir/Gift Shop
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One older child or adult is charged USD 10 per person per night when using existing beds.
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Wyndham Vacation Resorts - Nashville
Knights Inn - Nashville Downtown
Located 5 miles from the Nashville Convention Center, this Tennessee hotel boasts an outdoor pool and free property-wide Wi-Fi. Guests can also start their day with a daily breakfast buffet.
Score from 236 reviews Good
GuestHouse Inn & Suites VanderbiltLocated a 5-minute drive from downtown Nashville, this smoke-free Tennessee hotel features a complimentary hot breakfast and free Wi-Fi. Vanderbilt University is a 6-minute walk away.
Score from 155 reviews Good
Club - Hotel Nashville Inn & SuitesThis hotel is conveniently placed moments from Nashville's top attractions, including the Nashville International Airport.
Score from 369 reviews Very good
Baymont Inn & Suites - Nashville Airport/BrileyThe Nashville Airport Baymont Inn and Suites is less than a 10 minute drive from the Nashville International Airport.
Score from 68 reviews Review score
Hot water would come and go. Basically my family had to take cold showers. Wifi never worked our entire stay. Was told we need to come to the desk to get our own towels that no one could bring them to us.
Location for Opry great
Need to remodel. No hot water in bathroom last day of our stay. Paint in bad shape. Breakfast skimpy.
For the price, good rooms and location.
My hot water went out and it took almost 2 wks to get fixed.
Water wasn't hot.
Wifi is good and it is cheap for sure.
Reception was not welcoming at all and breakfast lady was like a cold face witch! For some moment, we thought we were homeless people slept over at a shelter with arrogant hosts giving us free room and food. It was that bad! Sofa bed has no sheet and could not be laid down completely because TV stand is right there to stop it. I put down my credit card for reservation and clearly stated that I would pay cash which I did later, but after return I realized they charged my credit card after we checked out! Fortunately I asked for a receipt (which he did not offer me at the beginning). Definitely would not recommend unless you are REALLY on tight budget.
I have stayed here three previous times, but this was abysmal. There were holes in the sheets and stained bedding. Just terrible. Never again.
bathroom was so small my husband couldn't get into it with his wheelchair
I was afraid of staying here after seeing it has ~5.2 rating on booking.com, but in the end it turned out to be ok. Nice and spacious, room, comfy bed and close to airport.
It's old, not hot water.
Heater did not work moved to 2nd room had poop all over the tollet trash cans full coffee still in pot moved to 3rd room had mold in the closet
IT was nicer than I thought it would be. The bed and pillows were comfortable. It had a small fridge and microwave.
The Staff was very helpfull
The price was a little bit high
No hot water, uncomfortable beds. OLD blankets, dust on curtains above the bed, hair dryer broke (they wanted me to dry my hair in another room). bug bites were on my daughter, ripped sheets, 2 towels ONLY! musty smell in the room. Stove filthy, furniture broken, door broken, PTAC did not cool the room. unconcerned management, pitiful. I would NEVER recommend or stay again!
New iron !
No hot water, Smelled moldy, carpet was old and dingy, everything very dated.
Water did not get hot, barely got warm. Found blood stain on underside of comforter.
A brilliant staff and too friendly .. the car parking was available any time in front of my room
Need to upgrade some facilities like TV to LED and the furniture to modern ones
Breakfast is served too late. I have to leave by 615am
It's close to the airport (if that's important to you), it's not so far from downtown and the price is good. Clean rooms.
Room service didn't clean the room on the first day, we came back an the end of the day and nobody made anything. Breakfast is pretty basic.
Size or rooms and location
Dirty bathroom and floors. Needs to be remodel badly could be a great hotel if updated. Only good enough for one night stay when everything else is booked.
it was clean
the ice machines were out of order, the walk ways were full of old furniture....
The room was clean, and it was a great value. Had a fun trip.
One of the air conditioners in the suite didn't work well which made it hot. Duct tape fixed the bottom of the door.
The beds. I had a king size bed and it was so comfortable and quiet. Not creaky like an older bed would be. The room was clean, The staff was very helpful and accommodating.
My main complaint would be the oven in the kitchenette. It cooked about 200 degrees hotter than what it says according to my mother. It caused our dinner to catch on fire. The other issue was the continental breakfast. The menu was waffles one day and biscuits and gravy the next over and over. The bread they had for toast was a bit stale and they didn't have much of a selection. Waffles/ biscuits, toast, bagels, cereal, and some fruit was about all they had. Pretty disappointing.
Someone came knocking on our door and when I called the office the receptionist which was a guy told me on Saturdays they normally get the wrong door. They need security around the parking lot
The room was so nasty! Stains on bed and couch, cigarette burns all over the couch. Fridge was leaking all over the kitchen. Not worth a penny if you ask me I'm not picky when it comes to hotels but this place was not clean at all! The front desk did cooperate and give us our money back so it was nice we didn't have to argue about it but I wouldn't suggest this hotel...
The personal is disgusting. In fact the person in charge of the breakfast was cursing us
Everything. The personal is disgusting. In fact the person in charge of the breakfast was cursing us
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In Columbia, Hippos are creating havoc
How would you like wild hippos loose around the region? Pablo Escobar's hippos: A growing problem
A herd of hippopotamuses once owned by the late Colombian drug baron Pablo Escobar has been taking over the countryside near his former ranch – and no-one quite knows what to do with them.
It was in 2007, 14 years after Escobar's death, that people in rural Antioquia, 200 miles north-west of Bogota, began phoning the Ministry of Environment to report sightings of a peculiar animal.
"They found a creature in a river that they had never seen before, with small ears and a really big mouth," recalls Carlos Valderrama, from the charity Webconserva.
He went to look, and found himself faced with the task of explaining to startled villagers that this was an animal from Africa. A hippopotamus.
"The fishermen, they were all saying, 'How come there's a hippo here?'" he recalls. "We started asking around and of course they were all coming from Hacienda Napoles. Everything happened because of the whim of a villain."
Hmmm, maybe we can work out a trade. We can trade John McCain, Lindsey Graham, Thad Cochran and other RINOS, Yes ESPECIALLY you Karl Rove, for these hippos!
Report: You Betcha Sarah Palin Helped John McCain In 2008, has 2016 support Base – Washington Examiner
It's been debated for five years, and the conventional wisdom has generally concluded that Sarah Palin, the 2008 GOP vice presidential nominee, hurt Sen. John McCain's chances to beat then-Sen. Barack Obama for the presidency with her outsized and controversial personality.
But now a comprehensive new analysis of the so-called "Palin Effect" finds that in the final analysis, the former Alaska governor helped McCain by attracting more voters to the ticket, crushing a mainstream media view.
What's more, while she attracted wider press attention than most prior veep candidates, her actual impact for a No. 2 was about average.
"Palin had a positive effect on McCain," according to the new Palin analysis in the authoritative Political Research Quarterly.
Digesting mountains of data, two political science professors from Bradley University in Peoria, Ill., said their findings showed that the conventional wisdom that independent voters ran from the McCain-Palin ticket was wrong. They found that independent voters had the same reaction to Palin as Republicans, who largely liked her.
Both findings could provide a basis for a 2016 run for the presidency by the Tea Party favorite.
"Palin did not have a negative effect on McCain's voter share overall, nor did she result in eroded support for McCain among critical swing voters such as independents and moderates," the duo wrote.
Their analysis picked apart a recent report that Palin drove off voters and was uniquely divisive, claiming it was flawed.
Instead, it found that Palin "did not have a unique or unprecedented influence on the race; at best, she had precisely the same small effect on vote choice in 2008 that we would expect of any running mate."
Senate Approves Hagel For Defense Secretary After Historic Nomination Fight – Fox News
The Senate approved Chuck Hagel's nomination for Defense secretary Tuesday, ending a contentious battle that exposed deep divisions over the president's Pentagon pick.
After Republicans blocked the nomination earlier this month, they ultimately allowed for an up-or-down vote on Tuesday. The margin was historically close, with 58 senators supporting him and 41 opposing in the end.
Though Hagel is himself a former Republican senator, the resistance to his nomination showed an unusual level of distrust among many senators toward the man chosen to lead the Defense Department – at a time when the country is trying to wind down the Afghanistan war, while assessing emerging threats from Iran, Syria and elsewhere in the turbulent Middle East and North Africa.
Republicans had earlier held up the nomination largely over demands for more information from the Obama administration on the Sept. 11 Libya attacks.
But they also raised serious and recurring concerns about Hagel's record of past statements and votes on everything from Israel to Iran to nuclear weapons.
Sen. John McCain, a leading Republican, clashed with his onetime friend over his opposition to President George W. Bush's decision to send an extra 30,000 troops to Iraq in 2007 at a point when the war seemed in danger of being lost. Hagel, who voted to authorize military force in Iraq, later opposed the conflict, comparing it to Vietnam and arguing that it shifted the focus from Afghanistan.
McCain called Hagel unqualified for the Pentagon job even though he once described him as fit for a Cabinet post.
Senate Majority Leader Harry Reid asked what the delaying tactics had done for "my Republican colleagues."
"Twelve days later, nothing. Nothing has changed," the Democrat said on the Senate floor. "Sen. Hagel's exemplary record of service to his country remains untarnished."
Reid blamed partisanship over Obama's second-term national security team for the delay. Both Reid and Senate Armed Services Committee Chairman Carl Levin, a Democrat, warned that it was imperative to act just days before automatic, across-the-board budget cuts hit the Pentagon.
Hagel will succeed Defense Secretary Leon Panetta and join Obama's retooled national security team. Hagel's nomination bitterly split the Senate, with Republicans turning on their former party colleague and Democrats standing by Obama's nominee.
Republicans also challenged Hagel about a May 2012 study that he co-authored for the advocacy group Global Zero, which called for an 80 percent reduction of U.S. nuclear weapons and the eventual elimination of all the world's nuclear arms.
The group argued that with the Cold War over, the United States can reduce its total nuclear arsenal to 900 without sacrificing security. Currently, the U.S. and Russia have about 5,000 warheads each, either deployed or in reserve. Both countries are on track to reduce their deployed strategic warheads to 1,550 by 2018, the number set in the New START treaty that the Senate ratified in December 2010.
In an echo of the 2012 presidential campaign, Hagel faced an onslaught of criticism by well-funded, Republican-leaning outside groups that labeled the former senator "anti-Israel" and pressured senators to oppose the nomination. The groups ran television and print ads criticizing Hagel.
Opponents were particularly incensed by Hagel's use of the term "Jewish lobby" to refer to pro-Israel groups. He apologized, saying he should have used another term and should not have said those groups have intimidated members of the Senate into favoring actions contrary to U.S. interests.
The nominee spent weeks reaching out to members of the Senate, meeting individually with lawmakers to address their concerns and seeking to reassure them about his policies.
Hagel's halting and inconsistent performance during some eight hours of testimony at this confirmation hearing last month undercut his cause, but it wasn't a fatal blow.
There was no erosion in Democratic support for the president's choice and Hagel already had the backing of three Republicans – Sens. Thad Cochran, Mike Johanns and Richard Shelby. Sen. Rand Paul, R-Ky., also switched to support Hagel in the final vote.
Slublog has a great idea for the GOP if it ever hopes to regain control of the Congress, Senate, etc. Frankly, I ove the idea, it is very simple, and a winner! No more McCains!


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November 26, 2014
Buckingham County's longest playoff run in over a decade came to an end Saturday with a 27-0 loss to Brunswick in the VHSL Class 2A Semifinals in Franklin. The Knights end the season with a 10-4 record.
Scoring was at a premium in the first half and Buckingham found itself down just 7-0 at the half. But Brunswick played keep-away with the ball in the second half en route to the 27-0 win.
Craig Gill's team was trying to make it back to the state championship game for the first time since the 2002 Knights team, which lost to George Wythe in the final.
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