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Member ID
Remember Me
A local editor connected with us after finding us in the Chamber database. The story was on recycling and we eventually ended up on the cover of Biz Magazine. This helped us tremendously.
Stephanie McLarty
REfficient Inc.
For more infomation contact:
Hamilton, ON, Jan 15, 2014: Economic conditions in the Hamilton-Niagara Peninsula region have held steady in 2013, despite a weakening labour market and sluggish activity in the manufacturing sector, according to a new economic outlook released by the Hamilton Chamber of Commerce, in partnership with the Ontario Chamber of Commerce and the Credit Unions of Ontario.
After contracting by 1.5 percent in 2013, the overall labour force for the region is set to grow by about 1 percent in 2014 to 765,000 persons. The unemployment rate will hold steady at 7.1 percent through 2014, and is projected to shrink to 6.6 percent by 2015, below the projected provincial average.
Non-residential construction has been a positive driver of the economy in 2013. Private-sector construction will remain high throughout 2014, led by large scale investments including the Pan Am stadium in Hamilton, the St. Catharines-Niagara area Performing Arts Centre, and a $200-million retail outlet.
Housing prices in the region have risen by 12 percent since 2011, but will slow slightly over the next two years to about 2 percent per year as a result of higher interest rates and policy-induced slowing.
"The Hamilton Story, driven primarily by housing prices data and a lower than average unemployment rate, is getting significant national attention," says Keanin Loomis, President & CEO of the Hamilton Chamber of Commerce. "Those of us working hard on Hamilton's renewal know the Hamilton economy is still on the upswing in spite of difficult global economic headwinds since 2008 and a rocky year for our labour market in 2013 as demonstrated in the report. The positive outlook in the report for 2014 and 2015 will further add to that momentum."
Agriculture and agri-food activity will continue to be an economic driver for the region. Hamilton-Niagara Peninsula has seen the opening of Canada Bread Company's $100-million bakery, while benefitting from a national consolidation of Maple Leaf Foods operations that led to a $395-million facility in Hamilton and a distribution plant in Puslinch slated to be operational by 2014. The region is also benefitting from agriculture-related investment, with National Steel Car winning a contract to construct 1,000 rail cars for Saskatchewan's potash industry.
"As evidenced by the lack of hand-wringing over the closure of US Steel operations, Hamilton is buoyed by the fact that we are the most diversified economy in Canada. Through our support for local business and advocacy initiatives in emerging sectors, the Chamber will continue to provide leadership in the community to further develop life sciences, creative industries and advanced manufacturing and in the attraction of a younger workforce." Loomis adds.
The report also highlights how the Hamilton area continues to move towards a knowledge-based economy anchored by McMaster Innovation Park, which houses Canmet Labs and a new automotive research centre.
Key Facts and Highlights:
● Employment is expected to grow by 15,000 over the next two years.
● The unemployment rate is projected to drop to 6.6 percent by 2015, down from 7.2 percent in 2012.
● The housing market is sluggish, as housing sales will dip in the next two years, a continuing trend in the region.
● Housing prices in the region have risen significantly since 2011, and growth will slow slightly over the next two years. Average housing prices have risen from $295,000 in 2011 to a projected $343,000 in 2015.
● The region will see a fairly significant increase (4.4 percent) in the number of residential building permits issued in 2014.
● The region is expected to create 15,000 jobs over the next two years, making it a strong performer in Southern Ontario.
Download the full economic outlook at: https://db.tt/aK9ZKwBT
Established in 1845, the Hamilton Chamber of Commerce is the definitive "Voice of Hamilton Business". Representing over 1000 members and 75,000 employees, it champions the interests of ethical, free enterprise by effectively engaging business, community, and government leaders in the promotion of the long-term economic prosperity of our region.
Established in 1845, the Hamilton Chamber of Commerce is the definitive "Voice of Hamilton Business". Representing over 1000 members and 75,000 employees, it champions the interests of ethical, free enterprise by effectively engaging business, community, and government leaders in the promotion of the long-term economic prosperity of our region.
- 30 -
For more information, contact:
Keanin Loomis
President and CEO.
t. 905-522-1151 ext 229
A pdf version of this media release can be found here
The Hamilton Chamber of Commerce asked:
1) Do you know someone who is the ultimate Hamiltonian?
2) Do you know someone who works tirelessly for their community?
3) What Hamiltonian, in your estimation, made the most impact on this community in 2013?
And you answered! We are pleased to announce the following nominees for the Hamilton Community Awards:
76th annual Royal Bank Distinguished Citizen of the Year:
Joey Coleman, joeycoleman.com
Goce Dimitrioski, Volunteer365
Jean-Paul Gauthier, September Seventh Entertainment Ltd
Jeff Paikin, New Horizon Development Group
Dr. Nathalie Yan, Yan Health Care Inc
Hamilton Spectator Youth Volunteer of the Year:
Richard Armacinski, Cardinal Newman Catholic Secondary School
Felicia Binotto, Ancaster High School
David Bowman, St. Mary Catholic Secondary School
Tanya Joseph, Sir Allan MacNab Secondary School
Monica Nguyen, Orchard Park Secondary School
Kate Stericker, Orchard Park Secondary School
Jackson Virgin, Westdale Secondary School
Michelle Zhitomirsky, Highland Secondary School
A panel of distinguished citizens will use independent research, along with the support letters provided by the nominators, to reach its decision. Winners will be announced at the Hamilton Community Awards dinner on Tuesday, January 21, 2014 at Liuna Station.
The Hamilton Chamber of Commerce is proud to welcome Kent Austin, Ti-Cat Head Coach and General Manager, as our guest speaker for the evening.
Holiday office hours:
Monday, December 23: 8:30am - 4:30pm
Tuesday, December 24: 8:30am - 12:00pm
Friday, December 27: closed
Monday, December 30: closed
Tuesday, December 31: closed
Thursday, January 2: regular office hours (8:30am - 4:30pm)
The Hamilton Chamber of Commerce. All rights reserved.
Website Designed & Developed by Imagination Plus, Inc.
Hamilton Chamber of Commerce


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Baishe Srabon, its writer-director insists, is a psychological thriller. Directed by one of the most talented youngsters from the new brat-pack, featuring Bengali cinemas numero uno in a new avatar, the film created a mood of heightened audience expectation. This was kept alive by flooding the television channels with beautifully cut promos, trailers and teasers, imaginatively designed billboards at every street corner, and the music track of the film played and overplayed on every sound ambience. Sometimes, an overload of pre-release publicity can become a films undoing when it finally arrives in the theatres. Srijit Mukherjees second directorial film Baishe Srabon is a classic example of overhype and the film not living up to expectations.
The film suffers from too much psychological and intellectual complexity that gets in the way of the puzzle everyone is trying to solve. On the other hand, if one takes it to be a story that defines a kind of resurrection of a once-brilliant police officer gone to seed by bringing him out of his self-imposed seclusion to solve the insoluble serial killings by a mysterious Stone Man (remember the Mumbai Stone Man serial killer?), the climax, a real twist in the tale, rules this out too. Probir Roy Choudhury (Prosenjit.), consolidates the irreverent, irrepressible anti-hero who wears his anti-hero persona much like a badge that Anjan Dutt created in Ranjana Ami Aar Ashobona.
The film is scattered with so much of physical violence the serial killings that it neatly undercuts the moral and intellectual violence. It is real and physical violence because the poetry, be it Binoy Majumdar or Jeebonanando Das or whoever, or the poetry of the eccentric Nibaron Chakraborty (Goutam Ghose) who triggered the 1997 fire at the Kolkata Book Fair, most of it will go right over the heads of the audience. True that Post-modern cinema defines the mingling different creative genres like poetry and cinema or television and cinema or theatre and cinema. But somehow, it does not work in an environment where the audience is looking for some gripping, nail-biting, edge-of-the-seat moments of suspense, which Baishe Srabon fails to bring across. The electric chemistry of Soumik Haldars camera and lighting is comprised of hoodwinking chases down narrow lanes and bylanes of the city we do not frequent, all ending in an anti-climax. Technically brilliant but sadly, it does not add to the narrative of the film much.
The opening frames visualised and presented through an impressive, shocking shot of a sex worker being murdered - keeping the murder away from the frame establishes a stunning beginning. But after that, the film is little more than an exercise in intellectual filmmaking, perhaps in the process, defining a new genre that does not exist in film theory books. It does not maximize suspense except creating a false trail for the eccentric poet who keeps calling Rabindranath. Everyone thinks he is referring to Tagore. In the end, when there is a clear hint about the real identity of the Rabindranath he used to call up is, it is so sudden and so quick that one could easily miss out on it completely.
On the postive side, Baishe Srabon, however, is propped up with well-fleshed out and somewhat off-beat characterizations lived up to by the good performances of the entire acting cast. Prosenjits straggly, salt-and-pepper hair-do, as he sits guzzling his whisky or blowing smoke off his cheroot, or calling out to his twice-a-week servant Kanai is soon taken out of his dungeon-like home, made to slip into his old uniform, to get into the starry persona everyone is used to. His performance is filled with several touching moments, the most moving one being when he shuts the door of the electric crematorium carrying his wifes body and breaks down. It is difficult to believe that this is the same Poshenjit the crowds drool over. They will drool over this image too, but for a different reason the profanity the dialogue is littered with.
The triangular love story sticks out like a sore thumb in a psychological thriller. Raima Sen as Amrita seems to be more involved with her two boyfriends than with her job as investigating television journalist. Her character seems like an afterthought to add those cheesy tid-bits of intimate scenes between Amrita and Abhi. Parambrato is outstanding as the young and dedicated police officer who finally solves the crime. The scene showing him almost choking on his first whisky is beautiful. But would he have been able to had the killer not confessed to the killings in his own devious way? Abir Chatterjee as Amritas childhood sweetheart offers the sole point of wonderful relief in this otherwise dark film. Filmmaker Goutam Ghose is marvellous as the eccentric poet while Rajesh Sharma who claims he is the system stands out in a controlled performance. June Malia in a dialogue-free, briefest of cameos is very good too. It is the acting that saves the film from collapsing under itself.
The background music is so loud that sometimes, you miss out on the dialogue. And the song overload, never mind the wonderful lyrics and the melodies turned out by Anupam Roy add to the films undoing. No psychological thriller should have songs because they take away from the gripping element of suspense. Here, there are one too many. Even after the bloody climax is over, the sound track is filled with a song that is needless. It leaves behind an element of potential confusion about the entire film and one is left wondering what happened? Why did the killer begin his serial murders after this long a self-imposed hiatus suddenly?
The saddest thing about Baishe Srabon is that the film does not live up to expectations. But with its strong intellectual base the Hungrealist Poetry Movement in Kolkata relocated to fit into the story, it turns out to be targeted at a niche-niche audience. Does it really? Let us wait for a minute before we jump to conclusions about the alienating-the-audience theory. Filmmaker Srijit Mukherjee has very intelligently played around with the dialogue in a way that would automatically rope in the front benchers and the mass audience. There is an over- generous use of Bengali profanity and vulgar lines mouthed by the suspended, high-ranking police officer Probir Roy Choudhury the protagonist. The whistles and cat-calls in the stalls whenever a terrible profanity is uttered stand testimony. Even the young police officer Abhi (Parambrato Chatterjee) is seen wincing and visibly cringing when the older guy mouths obscenities that are an integral part of his nature.
|Garm Hava
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Sivaji Ganesan is regarded as the greatest actor ever in the history of Tamil cinema. Along with M...
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Noor Jehan was the biggest singing star of them all - the diva of Bollywood in the 1940s till Inde...


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Powder days. First lifts. Fresh tracks. And double blacks. I report on everything that makes #snowboarding awesome. Will post in gondolas and lift lines.


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Problem with new co-leader (Girl scouts)
Find a Conversation
|Sun, 10-22-2006 - 1:41am
I'm a co-leader for my daughter's girl scout troop. The leader and I get along great and this is our 2nd year leading the troop. This year we got a lot of new girls and I was unable to make our first couple meetings due to training at work that I couldn't get out of. There is this one abrasive parent that has rubbed me the wrong way just in the few short moments I talked to her...and my fiance has the same feelings for this woman...She's pushy and makes rude comments and ugh.
Anyway, I came in right after the last meeting I couldn't make ended and my leader told me that she just signed this lady up as another co-leader. It hurt me that she didn't even ask my opinion on it and just did it...I was especially upset knowing how much I dislike this woman...but the leader didn't know that. I considered stepping down but decided I would give this woman a chance before bailing. I gave her a chance and realized she's worse then what I thought!!
Now the leader realized what a mistake she has made and doesn't know how to get out of it. The woman has some great ideas for crafts etc but is over the top and pretty much tries to take over the troop. The leader has told her not to do certain things she suggests and then she goes and does them anyway. She seems to think that we need to make all our girls buy the brownie books ($20) and have them work on the try-its on their own from home...the leader and I are against this. We have bi-weekly meetings and this lady is pushing for weekly and the leader's husband said no way where we having weekly meetings. The new co gets all huffy if we don't like her ideas and she tries to boss us around...I don't like her and I don't care what she thinks of me so I just stand firm and stick to what I think and probably come off just as rude as her (but I don't do anything that would could be preceived wrong by the girls) and she's the only person I'm this way with and I think it's because she acts like she's Queen and everything needs to go her way and we're her servants and that doesn't fly with me. We took our girls on their first outing for the year today and that lady was telling the girls what to do like she was the leader, making decisions for the troop to the people running the event, like it's her troop and her decisions to make. This was a halloween event that had a haunted house and she was walking through it with a girl that got scared and what does the co do? Screams at every little thing and every corner, like that's something you should do to a scared child!! And another part of the event, they were turning lights out and she was loudly complaining about how stupid it was and how she didn't understand it...over and over and over again and when the girls screamed she starts yelling at them not to scream!! It was a halloween thing, it was supposed to be fun and I just wanted to yell that it was ok for them to scream but didn't want to "start" anything!!
The leader and the new co-leader went to the Brownie training this morning before our event and the leader told me that she came home crying to her husband because she doesn't know what to do since she doesn't like having this new co-leader and she doesn't want to make her angry but has realized her way of doing things and our way are totally different.
I am pretty much staying out of this since I didn't create this monster and I do beleive it's the leader's mess so she needs to fix it. I did tell her that she will probably have to pull her aside and say something to her and she knows that and apologized to me today for signing her up. But does anyone have any suggestions for how my leader should handle this?
|Sun, 10-22-2006 - 11:33am
Your leader & you should first get to know the rest of the parents & find another co-leader (together, since your both have to work with them).


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The Feed
Man About Town: Black Tie Dressing, Model Behavior, and the amfAR New York Gala
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Behind the Very Sexy Scenes of the Victoria's Secret Valentine's Day Shoot
Pretty much all of humanity can agree that the Victoria's Secret Angels are from another planet, not fit for us mere humans. As such, they're the ideal faces and bodies of the legendary lingerie brand's campaigns and commercials. Each year, they slip into something a little more comfortable around Valentine's day to shoot their famous V-Day spot, which is second only to their insane scantily clad fashion show. Lucky for us, and lucky for you, we've got a behind-the-scenes look at it. And naturally, we've their Super Bowl picks. They're all firmly rooting for the Broncos; "Broncos! It's Manning's year!" says Lily Aldridge. We know that's what you're really focused on right now.read more
The GQ Eye: GQ on Style
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GQ's Angels
Before the 2013 runway show airs tomorrow night, brush up on every Victoria's Secret model to appear in the pages of GQread more
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The GQ Eye: GQ on Style
Every Look from the 2013 Victoria's Secret Fashion Show
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10 Essentials: Armando Cabral
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The GQ Eye: GQ on Style
11 Years Ago Channing Tatum Made His Male Modeling Debut
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Italy said two marines on trial for murder in India would return to the country by Friday, a stunning turnaround after Rome earlier unleashed a diplomatic furore by saying they would not go back.
Massimiliano Latorre and Salvatore Girone, granted special leave last month by an Indian court to return to Italy to vote in elections, had skipped bail.
The government said on Thursday it had received "ample assurances" from Indian authorities "on the treatment that the marines will receive and the defence of their fundamental rights.
"The government decided, also in the interests of the marines, to maintain the commitment taken when they were granted leave to take part in the elections to return to India by March 22," it said.
"The marines agreed to this decision," it added.
Outgoing Prime Minister Mario Monti met with Defence Minister Giampaolo Di Paola and Steffan de Mistura, a junior foreign minister who has taken a lead on the case, to discuss the issue on Thursday.
De Mistura said the decision was a "difficult" one.
Italian President Giorgio Napolitano said he appreciated the "sense of responsibility" displayed by the two marines.
The government had announced on March 11 that the marines would not return from their leave.
Italy insists the marines should be prosecuted in their home country because the shootings involved an Italian-flagged vessel in international waters. India says the killings took place in waters under its jurisdiction.
The two are accused of having shot dead two Indian fishermen they mistook for pirates off the Indian port of Kochi last year. They were serving as security guards on an Italian oil tanker.
After Italy said the marines would not return, Indian authorities forbade Italy's ambassador to New Delhi, Daniele Mancini, from leaving the country, saying he had broken a written promise.
Sonia Gandhi, the Italian-born head of India's ruling party, had accused Rome of an unacceptable "betrayal", and Prime Minister Manmohan Singh had warned Italy that there would be "consequences".
Italy had accused India of violating international laws on diplomatic immunity as the Indian Supreme Court issued a decision requiring Mancini to seek the court's permission to leave the country.
New Delhi also put its airports on alert to prevent Mancini from leaving.
Without legal protection he could be prosecuted for contempt of court.
A lawyer for the Italian government argued that Mancini still enjoyed diplomatic immunity and freedom of movement under international rules contained in the 1961 Vienna Convention on Diplomatic Relations.
European Union foreign policy chief Catherine Ashton on Tuesday defended Mancini, saying diplomatic immunity "should be respected at all times". Limiting his movement "would be contrary" to international obligations, she said.
Italy said it was trying to find a way out of the dispute that would satisfy both sides.
"The Italian government is working on a friendly agreement with India based on international law," Italian President Giorgio Napolitano's office said in a statement.
Relations between the two countries have also been soured by corruption allegations surrounding a $748 million deal for the purchase of 12 Italian helicopters, which the Indian government is now threatening to scrap.
The case of the marines caused more uproar in the local assembly of southwestern Kerala, the home state of the dead fishermen.
The opposition Communist party walked out of the assembly after their demand for an urgent discussion on how the Italian marines had been allowed to return home was dismissed by the ruling party.
"It's a shame on India that this case was dealt with casually," senior Communist leader P.K. Gurudasan told AFP.


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after traveling for about 11 hours we were grateful to arrive and find a neat, clean inn. Nice room, comfy bed, large shower; in room fridge and free coffee unexpected bonuses. Chuck was kind enough to stay up late and talk us in when we couldn't quite find it (GPS had a bit of a hiccup).
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This guest article from YourTango was written by Richard Drobnick. Men and women are different in many ways. They see the world through completely different perspectives. The key to understanding their differences is in the way that men and women communicate. Here are six important communication differences that you should be aware of, to help [...]
read more
This week, we read a great article by Meg Wolitzer in The New York Times about the ways in which novels written by men and women are perceived differently — both by readers and by publishers. She has many great points, and the artic... Read Post
This guest article from YourTango was written by Andre Moore and Dr. Lisa Kaplin. Both men and women find vulnerability attractive in a partner, for many different reasons. "She said," from Dr. Lisa Kaplin: Women truly do find vulne... Read Post


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Attention December 2014 Graduating Students
November 25, 2014
2015 Student Gift Survey
November 21, 2014
Celebrate the Union Board's Birthday with a Luau
November 21, 2014
Cover Drive and a Summer Dance Party at The Bog
November 21, 2014
Pakistan Student Association General Body Meeting
November 20, 2014
Mr. and Ms. Hawk Contest a Resounding Success
November 20, 2014
Summer-Style Tailgate at The Bog
November 20, 2014
Study Abroad Scholarship Deadlines Approaching for Summer and Academic Year 2015-16
November 19, 2014
- Attention December 2014 Graduating Students
Join the Hawk's Nest at the IIT Women's Basketball Home Opener
November 14, 2014
Men's Soccer Going to USCAA National Championships
November 05, 2014
Support Women's Soccer at Final Match of the Season
October 31, 2014
New Student Fan Section
October 30, 2014
Illinois Tech Athletics Volleyball Tournament
September 22, 2014
- Join the Hawk's Nest at the IIT Women's Basketball Home Opener
There are currently no events to display.
School of Applied Technology Archive
Microsoft-Multi University Hackathon Held in IIT's Idea ShopApril 10, 2014Students from IIT, UIC, Northwestern, University of Chicago, DePaul and others pursued learning and prizes at the Microsoft-Multi University Hackathon held in IIT's Idea Shop on April 5 and 6.
IIT ITM Student Wins Second Place in Cyber Aces State ChampionshipMarch 6, 2014IIT undergraduate Information Technology and Management (ITM) student Eric Tendian competed in the Cyber Aces State Championship offered by the Illinois Department of Employment Security (IDES).
IIT School of Applied Technology Launches New WebsiteMarch 6, 2014IIT School of Applied Technology has launched a redesigned website at www.appliedtech.iit.edu.
IIT's School of Applied Technology hosts NENA's ICE 8: Interoperability with Recording and Logging ComponentsNovember 11, 2013IIT's School of Applied Technology hosted the National Emergency Number Association's (NENA) ICE 8: Interoperability with Recording & Logging Components at the Rice Campus last week.
IIT School of Applied Technology Dean Dr. C. Robert Carlson, and His Former Student, Dr. Sargon Hasso, Receive the Award for Best Paper at the 2013 ACM Research in Information Technology (RIIT) ConferenceOctober 17, 2013Dr. C. Robert Carlson, dean of School of Applied Technology earned the best paper at the ACM 14th Annual Conference in Information Technology Education (SIGITE) and the 2nd Annual Conference on Research in Information Technology (RIIT), October 10-12.
IIT Hosts Real-Time Communications Conference and ExpoOctober 1, 2013IIT will host the ninth annual Real-Time Communications Conference and Expo Tuesday, October 15, 2013 through Thursday, October 17, 2013 on Main Campus, in Hermann Hall located at 3241 S. Federal Street.
ITM Faculty Member Jeff Kimont Has Passed AwayAugust 26, 2013It is with great sadness that IIT School of Applied Technology announces the passing of Jeff Kimont, an adjunct faculty member in the Information Technology and Management program.
IIT Institute for Food Safety and Health Launches New Academic UnitJuly 17, 2013Illinois Institute of Technology's Institute for Food Safety and Health (IIT IFSH) has launched a new academic unit, the Department of Food Science and Nutrition. The department is housed within IIT School of Applied Technology.
Blake Davis, INTM adjunct faculty member, spoke about climate change at Eco-Justice Collaborative on CAN-TV.July 8, 2013Watch YouTube video here.…
Stepan Shows Support for Industrial Technology Education at INTM 2013 Awards DinnerMay 14, 2013The IIT Industrial Technology and Management's 2013 "Outstanding Leader in Industry," F. Quinn Stepan Jr. impressed the crowd at the 18th annual INTM Awards Dinner.


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Added Jun 17, 2014
Brooklyn, New Yo...
I made my dress for the party. When drafting the pattern, I was inspired by a 1930s dress day dress pattern I had seen awhile ago. It had a sort of apron looking cut for the body. I modified the shape to be a play on the drop waist and added the flapperesque flair. I paper drafted the pattern and draped the collar, all the seams are sewn with French seams and the edges are all hand sewn. The slip underneath is vintage from The Slipperie, who was also a vendor at the party. I made my flower headband inspired by 1920s and 30s wedding headdresses.
More pictures of my dress and the party:
Cotton blend lace
Jul 22, 2014, 02.56 PMby kikiboo
You put Daisy Buchanan to shame, exquisite!
Jun 25, 2014, 01.10 AMby nadia r
so gorgeous! like the era of Vionnet & co.
Jun 23, 2014, 12.53 PMby janene
This is breathtakingly gorgeous. Finding it hard to tear myself away from your photos! :-)))
Jun 20, 2014, 06.42 PMby LEAs-Heart-ART
Well done :) impressive!
Jun 20, 2014, 06.00 AMby izbott
You did a wonderful job. It's perfect for a fashion book.
Jun 19, 2014, 01.57 AMby Byanka Ayala
Love your dress! The photographer did an excellent job, very beautiful
Jun 19, 2014, 04.35 PMby papermothballvintage
Thank you! I take my own pictures using a tripod.
Jun 25, 2014, 01.14 AMby nadia r
amazing, i will try that if I ever can't get a willing photographer
Jun 25, 2014, 09.57 PMby Byanka Ayala
Wow! You do an amazing job!
Jun 18, 2014, 05.09 PMby IDia
love the photos!
Jun 18, 2014, 08.43 PMby papermothballvintage
Thank you
Jun 18, 2014, 04.48 PMby slmnstyle
Stunning! You and the dress!
Jun 18, 2014, 08.43 PMby papermothballvintage
Thank you :)
Jun 18, 2014, 01.05 PMby alice9163
Perfect style right out of Charlie Chaplin movie.
Thank you xo
Jun 18, 2014, 08.47 AMby libra-s
Absolutely beautiful!
Thanks :)
Jun 18, 2014, 03.36 AMby ronnielee
I love your style and creativity. These photos capture the dress so beautifully..
Jun 18, 2014, 01.07 AMby kristikaarlop
Super cute:)
Jun 17, 2014, 08.14 PMby mbuchanan1
Beautiful! Your dress, head piece, hair style, and make-up are absolutely perfect
Jun 17, 2014, 05.56 PMby liliv-1
I'm speechless, this is real beauty!
Thank you xo
Jun 17, 2014, 05.36 PMby cris orange
This is true art: your styling and the pictures, so beautiful! One really feels as beeing put into that era!
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AboutA web log for all fans of Walt Disney, The Disney Company, and its many products. Using the theories behind Walt Disney's family oriented entertainment and education, this blog is intended to be a safe read for the whole family. Proud to be a part of Quality Will Out Omnimedia. The Disney Blog is not affiliated with The Walt Disney Company in any way. All Disney parks, attractions, lands, shows, event names, etc. are registered trademarks of The Walt Disney Company. The Disney Blog is affiliated with LaughingPlace.com, the number one Disney Fan site on the internet. Please see creative commons license at the bottom of this page for copyright information. All content on this website is my own and does not necessarily represent the views of my employer or anyone else on the planet. The Disney Blog is supported by advertising and some of the links on this site and in product reviews are revenue share affiliate ads. I also do accept product for review and to give away as prizes. However, I compose all my editorial separate from any decision regarding advertising or affiliate links. YMMV.
Tag Archives: live action
Disney's Cinderella Photo Gallery & Plot Synposis
If you're any sort of Disney fan, then you're familiar with the story of Cinderella — the poor child whose mother dies and is left in the care of a wicked stepmother who favors her own two daughters over Ella. … Continue reading
Posted in Film, Walt Disney Studios Tagged cinderella, disney's cinderella, Film, live action, movie marketing, plot synopsis, Walt Disney Studios Leave a comment
Annie Leibovitz Photo Graces Cinderella Poster
You saw the poster earlier with the first trailer for Disney's live action remake of Cinderella, but did you detect something special. Okay, Lily James as Cinderella is pretty special by herself, but the artistic eye of photographer Annie Leibobitz … Continue reading
Disney Teases Live Action Cinderella Movie for 2015
Disney released a teaser poster and the first trailer for "Cinderella" a live action feature inspired by the classic fairy tale. "Cinderella" brings to life the timeless images from Disney's 1950 animated masterpiece as fully-realized characters in a visually dazzling … Continue reading
Posted in Film Tagged cinderella, Film, live action, live action cinderella, movie, movie marketing Comments Off
Maleficent Trailer Released
The new trailer for Disney's Maleficent has been released and it looks fantastic. From what we can tell Angelina Jolie is as icy and evil as we thought she would be, but there is a layer of curious sentiment involved … Continue reading
Posted in Current Affairs, Film, Trailerland, Walt Disney Studios Tagged angelina jolie, disney, live action, magic, maleficent, movie, poster, sleeping beauty, special effects, trailer, villain 1 Comment
First photo of Lily James as Cinderella in New Live Action Movie
Production has begun on the live action version of Disney's Cinderella directed by Kenneth Branagh and featuring Lily James in the title role. Judging by this first photo released from the set, I think we're in for a treat. Here's … Continue reading
Posted in Film, Walt Disney Studios Tagged cinderella, cinderella movie, kenneth branagh, lily james, live action 3 Comments


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Just put it in the primary fermenter. I did fattyliver's recipe and my OG was 1.08. I can't wait till it's done!!!
I just brewed this Sunday and had a OG of 1.077. Also I made my own inverted sugar (Lyles Golden Syrup) but I left mine on boil till it started to caramelize to an amber color. It made just over two pounds and i pitched one pound. Based on my OG I should of pitched the other pound but was not sure if it would throw off the taste.
I went with WL500 Trappist Yeast since that seems to be the best selection based on feedback here. I created a 1200mL starter based on BeerSmith2 and pitched that.
I put it in my lager chest and set the temp to 68F. All I can say is the aroma after a couple days of fermentation is amazing. I hope it tastes as good as it smells.
I went out and bought a bottle of Chimay Blue so i can do a side by side when it is time. Its been a long time since I had some...and at $15 bottle I am glad I can homebrew it!
I just did another batch of this up, this time with the proper yeast and hops. OG was spot on at 1.074, but even after 5 weeks in the primary(I didn't bother with the secondary this time) It had only dropped to 1.018. The temp got a little hot during the mash a couple of times, and I did add an extra 1/4 lb of chocolate malt, but I figured it would finish lower. It sat in a 69-74ish temp range throughout, it may have gotten as high as 80 for a few days in my basement while I was gone fotr vacation with the a/c off.... Just hope 1. I don't get bottle bombs and 2. there's enough yeast alive to carb it up. The uncarbed beer at bottling was quite tasty. It'll only get better with a few months aging.
How is everyone aging there Chimay Blue Clone?
I have mine kegged and sitting in a lager chest at 52F uncarbed...Was wondering if just putting into my kegerator where it is 38F and letting it sit for a couple months to age will be ok...or should this beer age at a warmer temp?
Just got my batch into the primary fermenter last night, with a OG 1.076. Had to use Karos syrup, and used White Labs Trappist yeast. Can't wait!
Day 4 - Still bubbling at a healthy level but definitely slowing. Added another 16 oz of Karos (total 32) per brew shops advice.
Day 7 - Stopped bubbling, transferred to secondary but probably too early. Gravity 1.026. May need to repitch, but will wait 10 days.
Day 14 - Tastes quite good. Fruity, ever so slightly bitter aftertaste. Gravity steady at 1.026. Anyone think I need to repitch?
What was your final gravity?
It was still at 1.030 last Monday. That same day, I added some yeast nutrient and stirred the wort. I'll check the gravity again tonight.
I bottled the Chimay last week, after being in the secondary for about 5 weeks. The ABV was just a little under 8%. My OG was 1.082 and FG 1.02. The taste is great! I can't wait to drink it. I'm going to try and be patient and leave it in the bottles for at least a month before I try one.
We took a stab at brewing this beer this past Sunday. A couple of alterations though:
i mistakenly bought clear candi sugar instead of amber.
LHBS does not carry White Labs, so i used the Wyeast 1214.
LHBS had no Northern Brewer Munich LME, so i asked him for equal parts x-light and amber. He came up a little light, though and only gave me 9 lbs. And on top of that, i used a cup of the xlight to make the starter. Then i got nervous that i was going to be way low for my OG, so, went back to LHBS and bought some Light DME and added a pound and a half of that to the recipe.
Here is what it finally came down to:
Aromatic Malt (Belgian) 0.25 lb, Grain, Steeped
CaraMunich 0.50 lb, Grain, Steeped
Munich (German) 2.00 lb, Grain, Steeped
Special "B" (Belgian) 0.50 lb, Grain, Steeped
Torrified Wheat 0.50 lb, Adjunct, Steeped
Steeped for 40 minutes at 156 degrees.
Added 0.5 lb light DME and started boil.
Hallertauer (Germany) 1.00 oz, Pellet, 60 minutes
Styrian Golding (Slovenia) 1.00 oz, Pellet, 30 minutes
X-light LME 3.00 lb, Extract, @ Knockout
Amber LME 4.00 lb, Extract, @ Knockout
Light DME 1.00 lb, Extrackt @ Knockout
Candi Sugar, Amber (Belgian) 1.00 lb, Sugar, Other @ Knockout
Yeast Nutrient, 2 tsp @ Knockout
Whirlfloc Tab, 1 tab at Knockout
(boy, knockout was busy, and adding all that LME stopped the boil, so i brought it back up to boil and went about 10 minute extra)
OG came out much much lower than i had hoped/expected (although Brewtarget was telling me it was going to be low, i didn't believe it. Fattyliver, if you're still reading this, how did you get up to 1.09?). My OG was 1.079.
Wyeast 1214, made a starter two nights before from 1 cup LME and 4 cups water. Then bumped it up again the next night with 1/2 cup DME and 2 cups water.
First time i've done a starter, and was worried that i hadn't began that process early enough. One online calculator told me i needed 6 liters of starter! i didn't get anyhere near that, but i must have done alright, because it was off and bubbling within about 3 hours.
Today is Tuesday and it got a little cold last night, but it is still going. Can't wait til it's done so we can move it to secondary and give it a taste.


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Publications (111)645.36 Total impact
Article: High Eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection.[Show abstract] [Hide abstract]
ABSTRACT: During HIV infection, increase in CD57 expression among CD8+ T cells has been associated to immune senescence and defective immune responses. Interestingly, CD57 expressing CD8+ T cells exhibit dual profile being simultaneously highly cytotoxic (terminally differentiated effectors) and poorly proliferative (replicative senescent). Recent publications point towards a positive role of CD57 expressing CD8+ T cell subsets, presumably due to their high cytolytic activity. We further investigated the phenotype of CD57 expressing CD8+ T cells in healthy donors and during HIV infection combining CD57 expression to Eomesodermin (EOMES), a T-box transcription factor which determine, coordinately with T-bet, effector and memory CD8+ T cell differentiation. We defined in healthy donors two functionally distinct CD57 expressing CD8+ T cell subsets exhibiting different levels of EOMES expression: EOMES(hi)CD57+ and EOMES(int)CD57+ CD8+ T cells. EOMES(hi)CD57+ cells exhibited low cytotoxic activity but preserved proliferative capacity and IL-7 receptor expression, whereas EOMES(int)CD57+ exhibited obvious cytotoxic functions and more terminal differentiated phenotype. We next performed a similar analysis in different contexts of HIV infection: primary infected patients, long-term viremic patients, aviremic patients treated with antiretroviral therapy and HIV controllers, demonstrating higher percentage of CD57 expressing cells in all HIV infected patients regardless of virological status. When heterogeneity in EOMES expression among CD57 cells was taken into account, we detected significantly higher proportions of EOMES(hi)CD57+ cells among HIV-specific and non-specific CD8+ T cells from HIV-controllers compared to aviremic antiretroviral-treated patients and viremic patients. Importantly, such peculiar non-terminally differentiated EOMES(hi)CD57+ phenotypic profile was associated with viral control.Journal of virology. 08/2014;
Article: Potential Role for HIV-Specific CD38-/HLA-DR+ CD8+ T Cells in Viral Suppression and Cytotoxicity in HIV Controllers.[Show abstract] [Hide abstract]
ABSTRACT: HIV controllers (HIC) are rare HIV-1-infected patients who exhibit spontaneous viral control. HIC have high frequency of CD38-/HLA-DR+ HIV-specific CD8+ T cells. Here we examined the role of this subset in HIC status.PLoS ONE 01/2014; 9(7):e101920. · 3.53 Impact Factor
Article: Elevated IP10 levels are associated with immune activation and low CD4+ T-cell counts in HIV controller patients[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND:: Although HIV controllers (HICs) achieve long-term control of viremia in the absence of antiretroviral therapy (ART), they display marked immune activation. The levels of inflammatory biomarkers in HICs and the biomarkers' relationships with immunologic and virologic status have yet to be fully characterized. DESIGN:: A cohort study. METHODS:: Plasma levels of seven biomarkers [tumor necrosis factor (TNF)α, interleukin (IL)6, IL10, IP10, MCP1, sCD14, sCD163] were compared in 70 HICs, 33 HIV-1-infected, treatment-naive noncontrollers (viremic patients), 30 ART-treated patients and 40 healthy donors. In HICs, we investigated the interplay between biomarkers, cell activation and the CD4 T-cell count. RESULTS:: HICs had higher levels of IP10, TNFα and sCD14 than healthy donors did (P < 0.01 for each). Also, TNFα and sCD14 levels of the HICs were similar to those measured in viremic and ART-treated patients. However, the levels of IL6 and IL10 were significantly lower in HICs than in viremic or ART-treated patients. In HICs, only IP10 levels differed significantly from those in both healthy donors and viremic patients, and were positively correlated with the expression of CD8 and CD4 T-cell activation markers. The IP10 levels of HICs were still elevated 12 and 24 months after the initial assay. Lastly, IP10 levels at enrollment were negatively correlated with the CD4 T-cell count at enrollment and 12 months later. CONCLUSION:: HICs display a number of inflammatory features associated with persistent T-cell immune activation.AIDS 12/2013; · 6.41 Impact Factor
Article: Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers.[Show abstract] [Hide abstract]
ABSTRACT: CD8(+) T cell responses are thought to play an important role during HIV infection, particularly in HIV controllers (HIC) in whom viral replication is spontaneously controlled without any treatment. We have demonstrated that CD8(+) T cells from these subjects are able to suppress viral replication in vitro. In parallel, HIV-specific CD8(+) responses were shown to be strong and of high quality with proliferative abilities and cytotoxic capacities in HIC. The HLA-B*57 allele, which is associated with a better clinical outcome in HIV infection, is overrepresented in HIC. However, we showed that these patients constitute a heterogeneous group that includes subjects who present weak suppression of viral replication in vitro and HIV-specific responses. We performed an extensive study in 101 HIC (49 HLA-B*57(+) and 52 HLA-B*57(-)) to determine the impact of HLA-B*57 on the HIV-specific CD8(+) response. HLA-B*57-restricted response displayed better qualitative features such as higher functional avidity, higher proliferation capacity, higher cytokine production than responses not restricted by HLA-B*57. However, the highest frequencies of HIV-specific CD8(+) T cells were only observed in a subset of HLA-B*57(+) subjects. They were tightly associated with the ability to suppress viral replication in vitro. In contrast, the subset of HLA-B*57(+) subjects with a weak ability to suppress viral replication had significantly lower ultrasensitive viral load than all the other groups of controllers. In conclusion, both HLA-B*57 and the amount of ultrasensitive viral load seem to play a role in the HIV-specific CD8(+) T cell responses in HIC.Journal of Virology 10/2013; · 5.08 Impact Factor
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ABSTRACT: HIV-controllers spontaneously maintain HIV viraemia at an undetectable level. We aimed to describe the delay to control from seroconversion, the duration of control, and risk factors for losing control. HIV-controllers were identified from a pooled dataset of 24 seroconverter cohorts from Europe, Australia and Canada (CASCADE). HIV-controllers had ≥5 consecutive viral loads (VL) <400/500 copies/mL, while ART-naïve, for ≥5 years after seroconversion. End of control was defined as two consecutive VL >2000 copies/mL.Duration of control was described using Kaplan-Meier estimates; factors associated with duration of control identified using a Cox model. CD4 count evolution during control was described using a mixed model. Of 9,896 eligible seroconverters, we identified 140 (1.4%) HIV-controllers, the largest database of HIV-controllers followed from seroconversion. For 64 with VL measured within 24 months from seroconversion, median delay to control was 16.7 (IQR: 7.8-37.9) months. Probability of maintaining control 20 years after seroconversion was 0.74 (95% confidence interval (CI): 0.64-0.85). Occurrence of blips followed by return to undetectability did not increase the risk of loss of control (hazard ratio: 0.81 (95% CI: 0.10-6.70). However, CD4 cell loss during control was significantly accelerated in individuals with blips. In most individuals, control occurred rapidly after seroconversion; however, >3 years were required to achieve control in 25% of HIV-controllers. Control may be sustained even while CD4 levels are below 500 cells/mm, opening important new perspectives to understand the physiopathology underlying control.AIDS (London, England) 08/2013; · 4.91 Impact Factor
Article: Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles.[Show abstract] [Hide abstract]
ABSTRACT: The expression of certain HLA class I alleles, including HLA-B*27 and HLA-B*57, is associated with better control of HIV-1 infection, but the mechanisms responsible are not fully understood. We sought evidence that pressure from the human restriction factor TRIM5α (hTRIM5α) could contribute to viral control. The hTRIM5α sensitivity of viruses from both HLA-B*57+ and HLA-B*27+ patients who spontaneously controlled viral replication, but not viruses from viremic patients expressing these alleles, was significantly greater than that of viruses from patients not expressing these protective HLA-B alleles. Overall, a significant negative correlation between hTRIM5α sensitivity and viral load was observed. In HLA-B*57+ patients, the T242N mutation in the HLA-B*57-restricted TW10 CTL epitope was strongly associated with hTRIM5α sensitivity. In HLA-B*27+ controllers, hTRIM5α sensitivity was associated with a significant reduction in emergence of key CTL mutations. In several patients, viral evolution to avoid hTRIM5α sensitivity was observed, but could be associated with reduced viral replicative capacity. Thus, in individuals expressing protective HLA-B alleles, the combined pressures exerted by CTL, hTRIM5α and capsid structural constraints can prevent viral escape both by impeding the selection of necessary resistance/compensatory mutations, and forcing the selection of escape mutations that increase hTRIM5α sensitivity or impair viral replicative capacity.Journal of Virology 07/2013; · 5.08 Impact Factor
Article: A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8(+) T Cells.[Show abstract] [Hide abstract]
ABSTRACT: The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV-1-specific CD8(+) T cell responses directed against the immunodominant p24 Gag-derived epitope KK10 (KRWIILGLNK263-272) presented by human leukocyte antigen (HLA)-B(∗)2705. We found that cross-reactive CD8(+) T cell clonotypes were mobilized to counter the rapid emergence of HIV-1 variants that can directly affect T cell receptor (TCR) recognition. These newly recruited clonotypes expressed TCRs that engaged wild-type and mutant KK10 antigens with similar affinities and almost identical docking modes, thereby accounting for their antiviral efficacy in HLA-B(∗)2705(+) individuals. A protective CD8(+) T cell repertoire therefore encompasses the capacity to control TCR-accessible mutations, ultimately driving the development of more complex viral escape variants that disrupt antigen presentation.Immunity 03/2013; 38(3):425-36. · 19.80 Impact Factor
Article: Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study.[Show abstract] [Hide abstract]
ABSTRACT: Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [PTCs]) whose viremia remained controlled for several years after the interruption of prolonged cART initiated during the primary infection. Most PTCs lacked the protective HLA B alleles that are overrepresented in spontaneous HIV controllers (HICs); instead, they carried risk-associated HLA alleles that were largely absent among the HICs. Accordingly, the PTCs had poorer CD8+ T cell responses and more severe primary infections than the HICs did. Moreover, the incidence of viral control after the interruption of early antiretroviral therapy was higher among the PTCs than has been reported for spontaneous control. Off therapy, the PTCs were able to maintain and, in some cases, further reduce an extremely low viral reservoir. We found that long-lived HIV-infected CD4+ T cells contributed poorly to the total resting HIV reservoir in the PTCs because of a low rate of infection of naïve T cells and a skewed distribution of resting memory CD4+ T cell subsets. Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure.PLoS Pathogens 03/2013; 9(3):e1003211. · 8.14 Impact Factor
Article: High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers.[Show abstract] [Hide abstract]
ABSTRACT: The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.PLoS ONE 01/2013; 8(9):e74855. · 3.53 Impact Factor
Article: CD8 T-Cells from Most HIV-Infected Patients Lack Ex Vivo HIV-Suppressive Capacity during Acute and Early Infection.[Show abstract] [Hide abstract]
ABSTRACT: The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.PLoS ONE 01/2013; 8(3):e59767. · 3.53 Impact Factor
Article: NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers.[Show abstract] [Hide abstract]
ABSTRACT: NKG2D mediates an important co-stimulatory pathway in CD8 T cells. In HIV infection, we found that NKG2D expression on both total and HIV-specific CD8 T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8 T cells. We observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8 and HIV-specific CD8 T cells. The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function.JAIDS Journal of Acquired Immune Deficiency Syndromes 09/2012; · 4.65 Impact Factor
Article: HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy.[Show abstract] [Hide abstract]
ABSTRACT: The occurrence of viral control after interruption of an antiretroviral treatment (ART) initiated during primary HIV-1 infection (PHI) is rare and the frequency and predictive factors of such a control are unknown. Within the French ANRS PRIMO Cohort, 164 patients interrupted ART initiated during PHI. We compared patients whose viral load (VL) remained undetectable (<50 copies/ml) or low (50-500 copies/ml) 1 year after ART interruption to those who evidenced a rapid viral rebound. After ART interruption, VL remained undetectable for a median time of 4.5 years in 14 patients ('post-ART controllers') and low in another 14 patients for a median time of 1.5 years. Post-ART controllers also maintained higher CD4(+) T-cell counts compared to other patients. Female gender, a high CD4(+) T-cell count and low VL during PHI, and a high CD4(+) T-cell count and low HIV DNA levels at interruption, were associated with post-ART HIV control. Treatment characteristics did not differ between controllers and non-controllers. Post-ART controllers had lower specific CD8(+) T-cell frequencies and CD8(+) T-cell activation on ART and after ART interruption than non-controllers. Few patients maintain very low VL after interruption of treatment initiated during PHI. Early patient characteristics were the main factors of viral control, although early initiation of ART and the effect of ART on reservoir might contribute to control.Antiviral therapy 08/2012; 17(6):1001-9. · 3.07 Impact Factor
Article: Continuous versus intermittent treatment strategies during primary HIV-1 infection: the randomized ANRS INTERPRIM Trial.[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVES:: The ANRS-112 INTERPRIM trial assessed whether fixed-cycles of antiretroviral treatment interruption (ART-STI) combined or not with pegylated interferon alpha-2b (peg-IFN) could lower viral load and achieve a healthier immune system in patients diagnosed during primary HIV-1-infection (PHI). DESIGN AND METHODS:: Patients were randomized to receive either continuous ART (cART) during 72 weeks, or cART during 36 weeks followed by three ART-STIs, or the same ART-STIs associated with peg-IFN during the first 14 weeks and each interruption (ART-STI-IFN). Treatment was stopped at week 72. Final evaluation was based on plasma HIV-RNA level 6 months after the last treatment interruption. RESULTS:: Eighty-seven percent of patients achieved undetectable HIV-RNA at week 32, with no deleterious impact of sequential treatment interruptions (STIs). Viral rebounds during interruptions were lower in the ART-STI-IFN than in the ART-STI group and during the second and third interruptions compared with the first one. However, HIV-RNA levels, CD4 T-cell counts and CD4 T/CD8 T ratios were similar between groups after the 6-month interruption, with a persistent effect on CD4 T cells and total cell-associated HIV-DNA levels. Predictive factors of virological outcome were HIV-RNA and HIV-DNA levels at PHI and HIV-DNA levels at treatment interruption. HIV-specific responses did not differ between strategies and were not associated with outcome. Forty-eight percent of patients experienced treatment resumption during long-term follow-up without difference between groups. CONCLUSION:: When initiated during PHI, STIs associated or not with IFN did not result in a different outcome as compared to cART. All regimens showed a high response rate and a sustained immunological benefit after cessation.AIDS (London, England) 07/2012; 26(15):1895-1905. · 4.91 Impact Factor
Article: Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection.[Show abstract] [Hide abstract]
ABSTRACT: Regulatory T-cell (Treg) quantification in human immunodeficiency virus (HIV) infection remains ill defined because of the lack of reliable specific markers to identify human Tregs and the diversity of clinical stages of HIV infection. Using a recently described Treg identification strategy based on CD45RA and Foxp3 expression, we performed an extensive quantification of total, naive (CD45RA(+)Foxp3(low)), and effector (CD45RA(-)Foxp3(high)) Tregs in different contexts of HIV infection: primary HIV infection, long-term viremic patients, aviremic patients treated with highly active antiretroviral therapy, and HIV controllers. We showed that although total Treg percentages were mildly affected by HIV infection, Treg absolute numbers were significantly reduced in all groups studied. We demonstrated that although naive Treg numbers were essentially preserved, effector Tregs were consistently affected during HIV infection. Finally, we demonstrated that effector but not total or naive Treg numbers were negatively correlated with the magnitude of HIV-specific CD8 T-cell responses.The Journal of Infectious Diseases 03/2012; 205(10):1510-9. · 5.85 Impact Factor
Article: Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIV.[Show abstract] [Hide abstract]
ABSTRACT: Interleukin (IL)-2 therapy impacts T-cell homeostasis. Whether IL-2 expanded CD4(+) T cells may persist following viral rebound has not been fully investigated. Patients with CD4(+) T cells 500/μl or more and HIV RNA less than 50 copies/ml were randomized to continue antiretroviral therapy (ART) either alone (n = 67) or combined with three IL-2 cycles (n = 81; 6 million units) twice daily for 5 days at weeks 0, 8, and 16 before stopping ART (week 24). Patients were followed up to 168 weeks. At week 24, median CD4(+) T-cell counts were 1198 and 703 cells/μl in the IL-2 and control groups, respectively (P < 0.001). At week 72, 27% (IL-2 group) and 45% (control group; P = 0.03) of patients were in failure (defined as no interruption of ART at week 24, CD4 drop below 350 cells/μl or ART resumption). After week 24, a biphasic decline (before and after week 32) of CD4 was noted -106 and -7 cells/μl per month in controls and -234 and -17 in IL-2 group (all P ≤ 0.0001). At week 96, IL-2-expanded CD4(+)CD25(+) T cells remained higher than in the control group (26 vs. 16%, P = 0.006). In IL-2-treated patients, CD4(+)CD25(+) T cells persisting despite viral replication allow a longer period of ART interruption.AIDS (London, England) 02/2012; 26(6):711-20. · 4.91 Impact Factor
Article: Acute Plasma Biomarkers of T Cell Activation Set-Point Levels and of Disease Progression in HIV-1 Infection.[Show abstract] [Hide abstract]
ABSTRACT: T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are predictive of the rate of progression towards AIDS. We evaluated whether the inflammatory profile during primary HIV-1 infection is predictive of the virological and immunological set-points and of disease progression. We quantified 28 plasma proteins during acute and post-acute HIV-1 infection in individuals with known disease progression profiles. Forty-six untreated patients, enrolled during primary HIV-1 infection, were categorized into rapid progressors, progressors and slow progressors according to their spontaneous progression profile over 42 months of follow-up. Already during primary infection, rapid progressors showed a higher number of increased plasma proteins than progressors or slow progressors. The plasma levels of TGF-β1 and IL-18 in primary HIV-1 infection were both positively associated with T cell activation level at set-point (6 months after acute infection) and together able to predict 74% of the T cell activation variation at set-point. Plasma IP-10 was positively and negatively associated with, respectively, T cell activation and CD4(+) T cell counts at set-point and capable to predict 30% of the CD4(+) T cell count variation at set-point. Moreover, plasma IP-10 levels during primary infection were predictive of rapid progression. In primary infection, IP-10 was an even better predictor of rapid disease progression than viremia or CD4(+) T cell levels at this time point. The superior predictive capacity of IP-10 was confirmed in an independent group of 88 HIV-1 infected individuals. Altogether, this study shows that the inflammatory profile in primary HIV-1 infection is associated with T cell activation levels and CD4(+) T cell counts at set-point. Plasma IP-10 levels were of strong predictive value for rapid disease progression. The data suggest IP-10 being an earlier marker of disease progression than CD4(+) T cell counts or viremia levels.PLoS ONE 01/2012; 7(10):e46143. · 3.53 Impact Factor
Article: CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory.[Show abstract] [Hide abstract]
ABSTRACT: There are few large published studies of HIV controllers with long-term undetectable viral load (VL). We describe the characteristics and outcomes of 81 French HIV controllers. HIV controllers were defined as asymptomatic, antiretroviral-naïve persons infected ≥10 years previously, with HIV-RNA <400 copies/mL in >90% of plasma samples. All available CD4 and VL values were collected at enrolment. Mixed-effect linear models were used to analyze CD4 cell count slopes since diagnosis. HIV controllers represented 0.31% of all patients managed in French hospitals. Patients infected through intravenous drug use were overrepresented (31%) and homosexual men were underrepresented (26% of men) relative to the ANRS SEROCO cohort of subjects diagnosed during the same period. HIV controllers whose VL values were always below the detection limit of the assays were compared with those who had rare "blips" (<50% of VL values above the detection limit) or frequent blips (>50% of VL values above the detection limit). Estimated CD4 cell counts at HIV diagnosis were similar in the three groups. CD4 cell counts remained stable after HIV diagnosis in the "no blip" group, while they fell significantly in the two other groups (-0.26√CD4 and -0.28√CD4/mm(3)/year in the rare and frequent blip groups, respectively). No clinical, immunological or virological progression was observed in the no blip group, while 3 immunological and/or virological events and 4 cancers were observed in the blip subgroups. Viral blips in HIV controllers are associated with a significant decline in CD4 T cells and may be associated with an increased risk of pathological events, possibly owing to chronic inflammation/immune activation.PLoS ONE 01/2011; 6(4):e18726. · 3.53 Impact Factor
Article: Spontaneous control of viral replication during primary HIV infection: when is "HIV controller" status established?[Show abstract] [Hide abstract]
ABSTRACT: Eight patients in the ANRS PRIMO cohort experienced early spontaneous viral control. Viral control was established a median of 6.2 months after primary human immunodeficiency virus type 1 infection and lasted a median of 4.1 years. Seven of the patients initially had detectable viral replication. For 4 patients, viral control was lost during follow-up.Clinical Infectious Diseases 10/2009; 49(6):982-6. · 9.37 Impact Factor
Article: Antiretroviral therapy initiation during primary HIV infection enhances both CD127 expression and the proliferative capacity of HIV-specific CD8+ T cells.[Show abstract] [Hide abstract]
ABSTRACT: HIV-specific CD8+ T cells from patients with primary HIV infection (PHI) and after antiretroviral therapy initiation were evaluated for CD127 expression and proliferative capacity and were compared with cells from chronically-infected patients, including long-term nonprogressors and HIV controllers. We studied 30 patients with PHI (from the Agence Nationale de Recherche sur le SIDA Primo-infection Cohort) and 33 patients with chronic HIV infection (including nonprogressor patients from the Agence Nationale de Recherche sur le SIDA ALT Cohort and the Agence Nationale de Recherche sur le SIDA HIV Controllers Study Group). HIV-specific CD8+ T cells were identified by costaining with HIV human leukocyte antigen class I pentamers. CD127 expression was assessed by flow cytometry and cell proliferation by carboxyfluorescein succinimidyl ester labeling. During PHI, most HIV-specific CD8+ T cells coexpressed CD27 and CD45RO, were highly activated, and showed weak Bcl-2 expression. Their CD127 expression was very low and correlated negatively both with HIV RNA and DNA levels and with expression of the activation marker CD38. CD127 expression correlated positively with CD4 cell count, Bcl-2 expression and proliferative capacity. Strong CD127 expression was observed in the two groups of chronically-infected nonprogressors. CD127 expression on HIV-specific CD8+ T cells increased in early-treated PHI patients, reaching levels similar to those observed in nonprogressors. In parallel, these cells acquired strong proliferative capacity. No change in CD127 expression or proliferative potential was observed in untreated patients. Early antiretroviral therapy initiation enhances CD127 expression on HIV-specific CD8+ T cells, reaching levels similar to those observed in aviremic nonprogressors, and restores their proliferative capacity.AIDS (London, England) 08/2009; 23(13):1649-58. · 4.91 Impact Factor
Article: Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses.[Show abstract] [Hide abstract]
ABSTRACT: "HIV controllers" (HICs) are rare individuals in whom HIV-1 plasma viral load remains undetectable without antiretroviral treatment. This spontaneous viral control in HICs is usually associated to strong functional HIV-specific CD8(+) T cell responses. Accordingly, we have recently shown that CD8(+) T cells from HICs strongly suppress ex vivo HIV-1 infection of autologous CD4(+) T cells, suggesting a crucial role of this response in vivo. Knowledge of the mechanisms underlying the CD8(+) T cell antiviral activity might help to develop effective T cell-based vaccines. In the present work, we further characterized the HIV-suppressive capacity of CD8(+) T cells in 19 HICs. CD8(+) T cells from 14 of the 19 HICs showed strong HIV-suppressive capacity ex vivo. This capacity was stable over time and was partially effective even on other primate lentiviruses. HIV-suppressive capacity of CD8(+) T cells correlated strongly with the frequency of HIV-specific CD8(+) T cells, and in particular of Gag-specific CD8(+) T cells. We also identified five HICs who had weak HIV-suppressive CD8(+) T cell capacities and HIV-specific CD8(+) T cell responses. Among these five HICs, at least three had highly in vitro replicative viruses, suggesting that the control of viremia in these patients is not due to replication-defective viruses. These results, on the one hand, suggest the importance of Gag responses in the antiviral potency of CD8(+) T cells from HICs and, on the other hand, propose that other host mechanisms may contribute to restraining HIV infection in HICs.The Journal of Immunology 07/2009; 182(12):7828-37. · 5.52 Impact Factor
Top Journals
Université Paris-Sud 11Orsay, Île-de-France, France
Unité Inserm U1077Caen, Lower Normandy, France
French Institute of Health and Medical ResearchLutetia Parisorum, Île-de-France, France
Hôpital Bicêtre (Hôpitaux Universitaires Paris-Sud)Lutetia Parisorum, Île-de-France, France
Hôpital Saint-Vincent-de-Paul – Hôpitaux universitaires Paris CentreLutetia Parisorum, Île-de-France, France
Institut PasteurLutetia Parisorum, Île-de-France, France
Pierre and Marie Curie University - Paris 6Lutetia Parisorum, Île-de-France, France
Université René Descartes - Paris 5Lutetia Parisorum, Île-de-France, France
Institut de Génétique Moléculaire de MontpellierMontpelhièr, Languedoc-Roussillon, France
Institut de Génétique et de Biologie Moléculaire et CellulaireStrasburg, Alsace, France


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Massage Chichester
(56) for Massage in Chichester
Beauty By Debbie - MobileLodge 834, 26 The HornetPO19 7BB Chichester07725707575
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Glorious Spa29 South StreetPO19 1EL Chichester01243 790917
Glorious spa has a range of beauty treatments to suit everyone. Glorious spa beauty treatments include: facials, massage, waxing, tanning, manicure, pedicure and others.
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Jo is highly qualified with more than twenty years experience in the health and beauty industry, both as a therapist and a lecturer. Her passion is advanced skin care and she is excited to be working ... massage, beauty therapist, beauty salon, skin care, beauty, facial, pedicure, beauty therapy
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Massage, and Reflexology. You'll also find that we offer Waxing, Electrolysis and Red Vein treatments or if you want to spoil yourself why not visit Spa Days. Based (since 1986) in a quiet and...
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Champneys60 East StreetPO19 1HL Chichester01243 819010Closed
Luxury Spa Hotels in England. Relax and indulge in deeply soothing Champneys Spa treatments, health spas, day & weekend breaks. We have four country health spa hotels (Bedfordshire, Hertfordshire,...
Acadamy Of Nail Training, Nail & Beauty Salon39A, SouthgatePO19 1DP Chichester01243 530318Closed
Right from the beginning Angela always knew she was destined for great things, especially as her father had always told her she was a Princess! After leaving school Angela decided to run away to the...
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Mark Shepherd, BSc (Hons), MBAcC, offers Five Element and TCM Acupuncture, Tui na massage, Reiki, Reflexology and Cosmetic Facial Acupuncture from Chichester, West Sussex and Petworth, West Sussex.
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Napiers Herbal Health Care11 Eastgate SquarePO19 1JH Chichester0131 343 3292
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Back2Health offer Chiropractic, Osteopathy and massage services in Hampshire and West Sussex at Petersfield, Midhurst, Alton, Chichester, Waterlooville, Portsmouth, Southsea and Basingstoke
Chichester Pain Clinic3 Chapel StreetPO19 1BU Chichester01243 774555Closed
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Win Win
Paul Giamatti stars as a struggling lawyer and volunteer wrestling coach who takes in his client's troubled grandson
Two ex-cons kidnap the daughter of a rich businessman with the intention of running off with the ransom money
If ever there was a film to make you wish talking in cinemas was acceptable, it's The Disappearance Of Alice Creed. The plot winds its way through so many twists and surprises its near impossible not to continuously elbow the person sat next to second-guess what's coming up. This also makes it quite a difficult film to describe without giving much of the plot away, which is a shame as it's the twists that make this thriller worth watching. Both plot and the film's quality hop and skip about to an unexpected rhythm.
The opening sequence is one of the more impressive in British cinema for a good while. Without any dialogue, save the screams of Alice Creed, the first ten minutes sets out the situation brilliantly. Two men, Danny and Vic, kidnap a girl (Gemma Arterton), tie her naked to a bed and take photos of her. In the silence you're never sure what the men are thinking or aiming for, which makes for great drama.
The two men, it emerges, are ex-cons who shared a cell in prison. 'Inside' they cooked up a plan to kidnap a rich girl, hold her ransom and jet off to some paradise to start a new life. Eddie Marsan as Vic, the older of the two ex-cons and the operations mastermind, is as brilliant as always. Despite Vic's fondness for sinister plots, it's hard not to warm to his simple nature and dreams of a better life. Full of past regrets and nothing to live for, his dreams of new beginnings make him quite endearing. In contrast, the younger Danny (Martin Compston) is less wedded to Vic's plan. His capricious behaviour makes it difficult to tell when hes being sincere, childish, brainwashed or just lying.
Having only a cast of three actors throughout the entire film makes for a theatrical spectacle, blended with cinematic sensibilities. Yet with such a strong and expressive set of actors, the script is a disappointing let-down when the characters do actually speak. Many of the lines seem to be lifted from Tarantino's cutting room floor, and have a corniness that distracts from the tension that's built up. Much of the tension is generated by what the characters don't say; guessing their own individual motivations under a highly pressurised and traumatic situation creates splendid suspense.
In addition to the multitude of twists, the film strains the audience's suspension of disbelief on a number of sticky questions. How do they get a screaming woman up a block of flats in broad daylight without raising suspicion? Is Eddie Marsan really that undistinguishable in a balaclava? Where did they get all the money for all the equipment? Couldnt they have just gone away with that?
There's a Shallow Grave feel to the ending, which is frustratingly foreseeable. Mainly because the character you're supposed to be rooting for appears at odds with who you're actually rooting for. As going into detail would give too much away, we'll just have to remain silent, which in this case is probably for the best...
An enjoyable and original ransom plot thriller with as many twists and turns as a warped slinky. Will keep you guessing, so long as you can ignore the clumsy dialogue.
Paul Giamatti stars as a struggling lawyer and volunteer wrestling coach who takes in his client's troubled grandson
Tom Hardy, James Gandolfini and Noomi Rapace star in a feature-length adaptation of a short crime story by Dennis Lehane (Mystic River, Shutter Island), directed by Belgian filmmaker Michael R. Roskam (Bullhead)
Mark Cousins explores the relationship between childhood and film, and what each can tell us about the other on Film4
Escape into a season celebrating everything that's amazing about cinema on Film4.
Unfortunately I haven¿t been jet setting around the world this year to the various exciting international film festivals, but that¿s what makes the London Film Festival¿s compilation approach to progr
One of the best things about the London Film Festival¿s smorgasbord approach to programming is that, amongst the world premieres and gala screenings, there¿s an eclectic collection of exciting films o
Find out who voted for Film4.com's list of the top 100 must-see films of the 21st Century so far
A tooth-chattering voyage through the scariest movies ever made


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Tag: home page
Looking at 15 years of Apple's home page
Apple is known for its top-notch design and its webpage is no exception. Charlie Hoehn took an interest in Apple.com and used the Internet Archive Wayback Machine to examine how Apple's website has evolved over the past 15 years. Hoehn notes that Apple's home page has stuck with the same...
Apple site updated with exciting news from the WWDC keynote
The Apple website has been updated to show all of the wonderful new features that we'll be seeing in the next few months. iOS 5 "in the fall," Mac OS X 10.7 Lion "in July," and iCloud "concurrently with iOS 5." Each of the major images on the home page points to a new landing page. For...
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Back to Breitbart TV
He also reported that "upwards of 90% have a close relative here whether that be a brother, or sister, or aunt, or uncle, grandparent," and that these unaccompanied minors do not count as asylum-seekers escaping violence. Regarding the cost of transporting these unaccompanied minors throughout the US, Lankford reported that it would be cheaper to fly these children home first class with an escort.
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Century Link
Kitsap Credit Union
Martha & Mary
Poulsbo Dental Care
Well Being Health Center
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November 22nd, 2014
Mino Christante
A singer/songwriter reminiscent of Johnny Cash, Cat Stevens, or perhaps Leonard Cohen, Mino performs Americana in his one-man-show: 'Man+Guitar.'
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A simple visual grocery store scavenger hunt that we made, that you can make too, with whatever foods or snacks it is that you'd like to find.
A Sticky Spider Web Activity for Kids!
Follow the Lines to the Apple
16 Counting Activities for Preschoolers
Painting with Trucks and Other Things That Go
12 Sight Word Activities with a Lot of Hands on Learning
Yarn Apple Craft for Kids to Make
Display Kids Artwork from School in One Spot
Simple Baby Activities to Do This Week
Fine Motor Activity for Toddlers To Do with a Plastic Bottle
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Can Tim Howard Save the 4th of July?
- NewsBreaker
- Jul 3 '14
NewsBreaker Apr 02 '14OKCupid has urged users to stop using the internet browser Firefox after it became known that the CEO donated to an anti-gay fundraising campaign. The internet company responded saying Mozilla supports equality for all.
TODAY'S LOL: Samuel L. Jackson Performs "Boy Meets World" Slam Poetry
"NO FORD NATION": Fake Campaign Ads Make Fun of Controversial Toronto Mayor Rob Ford's Drug Use
FINAL FILM: James Gandolfini's Last Movie 'The Drop' Gets Trailer
COLBERT RESPONDS: Comedian Dedicates Entire Opening of Monday's Show to Racist Tweet Controversy
TRANSCRIPTS RELEASED: New Information From Cockpit Reveals No Additional Answers
CAUGHT ON TAPE: $400,000+ Lamborghini Aventador Crashes into Two Cars
GOING VIRAL: Insane Rope Swing Bungee Jump Built in South Africa
LEGEN-DARY ENDING?: HIMYM Ends 9 Year Run with Record Breaking Numbers; Mixed Reviews
FOOLING AROUND: Internet Becomes Even Less Reliable as April Fools' Pranks Take Over
TODAY'S LOL: "Do it for Denmark" Ad Sells Romantic Vacations to Raise the Country's Birth Rate
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