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Watch KOMO report on business fleeing Seattle
Businesses Fleeing Seattle: A combination of political policies is causing small businesses to leave Seattle. KOMO news reports on a trend of business owners fleeing the state's largest city for cheaper and more business-friendly towns like Lynnwood and Tukwila. No surprise, things like the upcoming $15 minimum wage and streets being handed over to buses and bikes are among the top complaints.
The End of Mail Delivery: A committee in the U.S. House is proposing ending door-to-door mail delivery, instead having postal workers deliver mail to communal boxes. The Republican-dominated House Oversight and Government Reform Committee approved the measure, saying it would save $2 billion annually.
Woman Missing 10 Years Returns Home: A woman missing for a decade is free after she was able to reach a family member on Facebook. The 25-year-old woman was forced into marrying and having a child with Isidro Garcia, 41, authorities allege, during that 10-year period.
Huge eBay Security Breach: Hackers accessed the eBay network earlier this year, viewing some 145 million user records, which some are calling the largest data breach ever. eBay is telling its customers to change passwords now. The hackers accessed records detailing email addresses, birth dates, and home addresses, but apparently no financial data.
31 Dead in China Bombing: Attackers in two SUVs drove through a market in China's Xinjiang region on Thursday setting off explosives, killing 31 and injuring 90. The attack happened in the city of Urumqi, and is being blamed on Muslim Uighur separatists.
Top stories
Will it really help?November 24, 2014Warm sleeping bags only make it easier for people to continue camping under freeway overpasses, says Michael Medved
Ben Shapiro: The Ferguson Days of RageNovember 21, 2014Ben Shapiro: We expect riots no matter what the outcome of the indictment
Ted Cruz channels his inner Taylor SwiftNovember 19, 2014Ted Cruz has made a compilation video of the many Jonathan Gruber "stupid Americans" comments.
The secret of GOP successNovember 17, 2014Michael Medved says competing for all ideologies and ethnicities remains the formula for success in American politics
Odd choice for Veterans DayNovember 12, 2014Salon.com has a funny way of honoring the military right before Veterans Day
Not Amnesty, but CompassionNovember 10, 2014Ben Shapiro says amnesty is not the answer to wooing Hispanics voters to conservatism
Seizing the initiative in WashingtonNovember 7, 2014Republicans should announce a brief set of clear goals and pledge to bring them to floor votes within 90 days
Republican Loss May End PartyNovember 5, 2014Ben Shapiro says that if Republicans lose the Senate, the party will be irretrievably broken
Lena Dunham threatens to sueNovember 4, 2014HBO's Lena Dunham sent a "cease and desist" letter to TruthRevolt demanding that it remove an article.
Why ID for guns, but not voting?October 31, 2014If it's somehow racist to require ID as a condition for voting, then how is it any less discriminatory to impose similar conditions for purchasing guns?
Anti-gun state senator arrestedOctober 31, 2014Missouri State Senator Jamilah Nasheed was arrested with a loaded 9mm
Gun control center stage at debateOctober 29, 2014Ben Shapiro and Michael Medved sat down with Ralph Fascitelli and KIRO Radio's Dave Ross to debate gun rights
KTTH Election GuideOctober 31, 2014Find out how our KTTH talk show hosts would vote in the 2014 Election
Ben Shapiro: The myth of the tiny radical Muslim minorityOctober 21, 2014Ben Shapiro takes on the myth that only a tiny minority of Muslims worldwide are radical.
Houston mayor forces pastors to turn over sermons on homosexualityOctober 16, 2014Houston Mayor Annise Parker wants sermons from pastors she says use the pulpit for politics.
Not a ChanceOctober 15, 2014Establishment Republican Party operatives don't think Chris Christie has a chance, according to Joe Scarborough
College football fans petition White House to pardon running backOctober 14, 2014
Ben Shapiro: Rise of the BarbariansOctober 10, 2014
Should we lower the voting age to 14?October 8, 2014If teens pay taxes like adults, then it's time they get to vote like adults, suggests a Daily Beast article.
Supreme Court refuses same-sex marriage cases, effectively makes gay marriage nationalOctober 7, 2014Refusal to take on cases a setback for gay rights activists' nationwide goals, but clears way for gay marriage in five states.
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KTTH gun rights debate
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Video: Gun rights debate In KTTH's third Freedom Series Debate, hosts Ben Shapiro and Michael Medved sat down with KIRO Radio's Dave Ross and Ralph Fascitelli, President of Washington Ceasefire, to take on initiatives 594 and 591 and other gun rights issues.
KTTH religious freedom debate
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Video: Religious freedom debate Watch the debate between Ben Shapiro, James Wellman, Valerie Tarico, Rev. Monica Corsaro, and Michael Medved.
KTTH Debate Video
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Video: Minimum wage debate Watch the debate between host Ben Shapiro and Socialist Seattle Councilwoman Kshama Sawant.
Real Estate Corner
Robin's Real Estate Reality Talk We are in a very unique market. Right now our area is showing signs of recovery. We are moving in a positive direction and gaining equity though are ways off from where we were in 2006 and 2007.


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Google Tech Talks
June 13, 2008
Spatial orientation is central to peoples senses. Symbols, icons and images in space make up what we look at. Diagrams maps and images can serve different purposes; lots of kinds of maps exist. In this talk I have been asked to talk about maps and discuss some of the things I see in Googlemaps "from the outside". The ever-present UI issues of orientation and focus are so concrete with maps. Integration of information without overloading a UI is always a danger and especially with maps; Annotation, undo and telling a story are all topics that seem central to the directions online maps are going. I will base my description of maps on projects on visual language such as virtual campus and placemap at MIT.
Speaker: Ted Selker
Dr. Ted Selker develops and tests new user experiences. He spent ten years as an associate professor at the MIT Media Laboratory where he ran the Context Aware Computing group, co-directed the Caltech/MIT Voting Technology Project, and directed the Counter Design Intelligence: product design of the future project. His work is noted for creating demonstrations of a world in which human intentions are recognized and respected in complex domains, such as kitchens, cars, on phones, and in email. Ted's work takes the form of prototyping concept products supported by cognitive science research.
Prior to joining the MIT faculty in November 1999, Ted was an IBM fellow and directed the User Systems Ergonomics Research Lab. He has served as a consulting professor at Stanford University, worked at Xerox PARC and Atari Research Labs, and taught at Hampshire College, University of Massachusetts at Amherst, and Brown University.
Ted's research has contributed to products ranging from notebook computers to operating systems. For example, his design of the TrackPoint in-keyboard pointing device is currently used in many notebooks, his visualizations have been responsible for performance and usability improvements in products, and his adaptive help system has been part of many IT products as well. Ted's work has resulted in numerous awards, patents, and papers and has often been featured in the press. He was co-recipient of the Computer Science Policy Leader Award for Scientific American 50 in 2004 and the American Association for People with Disabilities Thomas Paine Award for his work on voting technology in 2006.

subset: commoncrawl


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Global Research Agenda
It covers four main topics:
- employment and the quality of jobs
- returns on investment in social security
- inequality, instability and employment
- international labour standards and socially inclusive globalisation.
Studies on Growth with Equity series
Productive Jobs for Greece
After six years of recession, the Greek economy is showing some signs of recovery. Yet, unemployment has reached unprecedented levels, the risk of poverty and social exclusion continues to increase and enterprise investment is too weak to lead to a sustainable employment recovery. Based on an in-depth analysis of the present situation, the report identifies emergency measures to address the most pressing needs of vulnerable groups, notably youth and jobless households.
ILO Research News 1/2014
The world of work is experiencing significant challenges. Many advanced economies are facing significant unemployment and labour market inactivity, notably as a result of the global crisis which erupted in 2008. In emerging and developing countries, progress in reducing working poverty and informal employment has slowed down. Everywhere, new technology, changes in global production patterns and population ageing lead to new job opportunities, while also exerting a profound impact on the linkages between large enterprises and their suppliers, and on the nature of work itself. Income inequalities tend to widen. To shed light on these trends, the ILO has strengthened its research functions. The aim is to help discern the factors at work and to provide evidence-based analysis on how policies can best respond to emerging employment and social challenges. ILO Research News will present regular updates of the outcomes of this work.
Studies on Growth with Equity series
Spain: Growth with jobs
The Spanish economy has begun to recover from both the global financial crisis of 2008 and the sovereign debt crisis of 2011 and has made some employment gains. However, the recovery remains both incomplete and fragile. On current trends, it would take at least a decade for the unemployment rate to return to the pre-crises situation. It is therefore crucial to strengthen the employment recovery in order to ensure sustainable economic growth and avoid a further erosion in social conditions. The report points to a number of areas where Government and social partners could take action together to solidify these recent gains and build a new path to more and better jobs.
World of Work 2014: Developing with jobs
This year's edition focuses on developing countries and argues that quality jobs are a key driver for development. It draws on evidence from over 140 developing countries and finds that a common factor amongst those countries that have achieved higher per capita income and sustained growth was quality jobs.
Global report
Global Employment Trends 2014: the risk of a jobless recovery
The weak global economic recovery has failed to lead to an improvement in global labour markets, with global unemployment in 2013 reaching almost 202 million.
Studies on Growth with Equity series
Tackling the Jobs Crisis in Portugal
This report analyses employment and social trends in Portugal in the wake of the financial assistance programme agreed with the European Commission, the European Central Bank and the IMF. It also discusses international best practices available to inspire Portugal in its efforts towards cutting unemployment and boosting economic recovery.
Research Paper
Labour formalization and declining inequality in Argentina and Brazil
This paper analyses the processes of labour formalization in Brazil and Argentina and its interrelation with the evolution of income inequality over the 2000s. It also contributes to the debates on formalising the informal and how to reduce income inequality.


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Punta Gorda Condo Rental Photos and Description
3 Bedroom, 3 Bathroom, 6 Sleeps
Welcome to Burnt Store Marina & Country Club, a quiet, gated resort community on the shores of the Gulf of Mexico. Enjoy luxury waterfront lifestyle in this 2,234 square foot 'wedge' style corner condominium located within Grande Isles Tower III on prestigious Prosperity Point…a separate safe and private double-gated island situated in the middle of Burnt Store Marina's North and South basins.
Upon entering Grande Isle III #307, the 4th level of the 8 story building, your first sight is the sweeping western views over Charlotte Harbor and the Gulf through the great room wall of floor to ceiling windows. A sliding door leads to a large tiled lanai with patio furniture.
Imagine closing each day on your private lanai with a breathtaking sunset over an endless water view while sharing an intimate meal and a glass of wine. See the twinkling lights of Boca Grande on Gasparilla Island in the distance from the 4th floor of Grande Isle III, the final building project constructed in Burnt Store Marina. During the day, the view just below your lanai includes the daily parade of watercraft entering and leaving the marina north basin, some on their way to nearby islands like Captiva, Gasparilla and Cayo Costa or through the Boca Grande Pass. The attractive amenities area can be seen from your private lanai that include the sundeck/pool, hot tub and BBQ grilling area.
The condo is completely furnished and fully equipped with everything you'll need for your vacation or move in for the whole year, including a washer and dryer. All the conveniences of home, it is completely turn key, you won't need a thing. Be the first to occupy this condo since putting it in the rental program. This residence only has been lightly used as a vacation home.
The community at Grande Isle is welcoming and friendly. You can have all the privacy you could ever want or you can become involved in the many social events that the owners and fellow renters organize every week.
This spacious open floor plan is terrific for entertaining both inside and out…simply open the sliding glass door that leads to your harbor front tiled lanai. Accentuated by a pleasant color palette, neutral tile flooring, volume ceilings and an abundance of natural lighting. This customized residence features warm wood cabinetry, granite counters, upgraded appliances and custom made companion built-in pieces.
The great room enjoys a wet bar with Scotsman Bar refrigerator and icemaker, bar liquor cabinet, leather sofa and recliners, slate-tiled tables, custom companion entertainment center and impact sliding glass doors that lead to the waterfront lanai. Fabulous built-ins nicely surround the 60" inch Sony HD large screen TV complete with premium cable, surround sound, DVD player plus an abundance of storage.
A fully equipped gourmet style kitchen features lightly used upgraded appliances including a Bosch dishwasher, KitchenAid convection & microwave ovens, granite breakfast bar, custom pull-outs, full size pantry, terrific task and under counter accent lighting. Abundant workspace allows you to prepare some pretty special culinary delights.
Inviting dining area boasts a hand crafted companion buffet server that spans the dining room wall and has seating for (6) that is expandable.
Nice appointments include warm paint tones accentuated with (2) tray ceiling areas in the entry foyer dressed in faux finish and crown molding. The oversized tile flooring throughout the main areas is a snap to clean up with the 'easy sweeps' on the whole house central vacuum system.
The laundry room has a full size washer and dryer, large laundry sink, storage cabinets and a closet.
Just outside your door as you exit the condo is the elevator to the ground level indoor parking, trash chute and open air balcony overlooking the island and Marina North Basin Harbor. This is the place to enjoy the sunrises with a cup of coffee. Everything is well maintained and well-lit.
The Grande Isles Building has the ground level reserved for secure gated indoor parking with easy access to elevators. There is (2) assigned indoor parking spots plus additional outdoor parking. Golf car parking, bicycle storage racks, kayak storage, disposal bins for recycling, dry cleaning pick-up closet, storage unit, car wash station in the outside parking lot and carts for luggage & groceries are all available. At the entrance of Burnt Store there is a 24 hour manned gatehouse. A call box is located outside the main gate of Grande Isle III for guest announcement.
Incredible amenities and benefits for Grande Isle III residents just steps away from the condominium are: Dramatic two-story grande salon with an impressive climbing staircase ascending to the luxurious amenitity level…..Fully-equipped fitness center complete with men's and women's changing areas, sauna and steam rooms…..State-of-the-art, tiered (16) seat private movie theater with surround sound stereo and wet bar. Bring your DVD, popcorn, refreshments of choice and prepare to kick back in the reclining chairs…..The clubhouse/social room provides a warm elegant area complete with full service bar, catering kitchen, billiards table, gaming tables, grand player piano, library, wireless internet, large screen plasma TV and oversized windows overlooking the beautifully landscaped pool area. What a great place for gatherings and private parties !…..Olympic size heated swimming pool, jetted spa hot tub Jacuzzi, elevated sundeck and large patio area with elegant pool furniture, multiple BBQ grills and umbrella tables. The ultimate spot to relax and soak up the sunshine…..Lushly landscaped garden deck offering spectacular water and preserve views with a large water fountain.
The marina is just a few steps from the front door. There is a nice boardwalk that circles Prosperity Point Island and runs along both sides of the north and south marina basins. It is nice to wake up, grab your morning coffee and take a stroll around the marina and admire all the beautiful boats and the gorgeous waterfront homes.
Adventure awaits you here at your new residence in paradise !
- Suitability:
- Long-term Renters Welcome
- non smoking only
- not suitable for children
- pets considered
- wheelchair accessible
About Grant M Gegare
Currently residing in Green Bay, WI (GO PACKERS !) I recently purchased this magnificent condominium from the original owners who only vacationed here in the past…..I most recently owned and sold a smaller unit in an adjacent building, prior to upgrading into this unit……Since I'm not set to retire for at least another 10 years, I'm looking to rent out this place periodically throughout the year until some day I'm able to live here…..I visit the property regularly and take a great deal of pride in offering you an inviting, well maintained, well appointed, carefree home that replicates a fine hotel.....I do promise that my condo is everything it appears to be and I believe it is furnished and equipped to make your stay everything you would expect…..I do have additional pictures and a virtual-tour video I can send upon request….. I would also consider a rent-to-own option with a sales price of $459,000.00 (this figure is 60% of the total investment by the former original owner in 2006). This would allow me to upgrade one final step into a 'penthouse' unit within the complex. This condominium is not currently listed for sale, nor would it be anytime soon…..I hope you will choose to be my guest and enjoy all of the amenities and activities that this Grande Isles III condominium has to offer as you investigate this wonderful part of Florida.
Why Grant M Gegare chose Punta Gorda
I fell in love with Burnt Store Marina & Country Club the moment I drove onto it because it is so beautiful…..The building and grounds are attractively maintained by a professional and friendly onsite staff…..The fact that the condominium association was financially strong, well managed and being a gated community provided a lot of security and peace of mind…..Being a quiet secluded waterfront resort located on the Gulf of Mexico with many onsite amenities, your near enough to shopping, medical facilities, beaches and international airport service at Fort Myers…..In the winter the weather is warm and mild…..In the summer the cool tropical breezes, occasional afternoon showers, and warm gulf waters make it extremely enjoyable as well…..Spring and fall are the best kept secret…..Simply put, perfect weather year-round…..Any time of the year is a great time to visit SW Florida…..This really is an exceptional get away destination.....It is all here so you can do as much or as little as you want !
What makes this condo unique
Evening plans often revolve around the spectacular sunsets that fill the sky like great paintings & are unique every night, enjoyed from the spacious lanai or anywhere in the living area or master bedroom. (Even from the kitchen!)….. You can start each day with a stroll on the boardwalk around the marina…..This highly sought after 2,065 sq.ft. (+169 sq.ft. lanai) condominium is one of the few 'wedge' style corner units available that offer a widespread view versus the many smaller 1833 sq. ft. 'straight' units…..The lanai is screened on three sides providing great cross ventilation and a spectacular panoramic view…..The attractive amenities area can be seen from your private lanai that include the sundeck/pool, hot tub and BBQ grilling area. Only a few units in the complex are situated for this view….A beautiful kitchen for people who like to cook and fully equipped with everything you would need for a gourmet dinner…..Realizing that sometimes you have to be 'in touch', I have wireless internet/WiFi in the condo free for you to use…..I bought this particular unit because it was seldom used and never rented…..A unique property on an amazing isle location, with all the amenities that you would expect…..Life doesn't get any better than this, you will not want to leave!


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1982 Motorcycles for Sale(1 - 15 of 242)
$1,000 1982 Yamaha Virago XJ920JYamaha · Litchfield, MIYamaha XJ920J Virago I took on trade and now need to sell it to get my money. Runs great & looks really nice. Right now it's being store...Amy N. · 2 days ago
$2,500 1982 Honda 750 kHonda · New Rochelle, NYWow, amazing condition, With new battery and tires. The chrome is a 9 1/2. The paint is really nice . Adult owned. Only 17,000 miles. Ful...Marshall S. · 2 days ago
$2,295 1982 Honda Nighthawk 750Honda · New Rochelle, NYAdult owned well cared for original motorcycle . Ready to ride, recently tuned and changed all fluids. All work done by Honda. Runs and s...Marshall S. · 2 days ago
$3,500 1982 Ducati Superbike Bimota SB-3Ducati · New York, NYRare 1092 Bimota SB-3, all original 4507 kilometers (2816 miles) in perfect condition, never damaged, no accidents, full history - a beau...Kim P. · 5 days ago
$1,500 1982 FLH Harley Davidson ShovelheadHarley-Davidson · Oviedo, FLVIN (Vehicle Identification Number): 1HD1ADK11CY017117 Year: 1982 Exterior Color: Black Make: Harley-Davidson Model: Touring Vehicle Tit...Theo D. · 1 week ago
$750 82 Honda V45Honda · Crystal Lake, ILGood runner, needs some TLCJim C. · 1 week ago
$2,300 1982 Suzuki GSX 1000 Katana SportSuzuki · Ottawa, KSOriginal unrestored bike right down to the original tires. Possibly one of the finest examples you may come across. Tires are not weather...Grallot H. · 1 week ago
$4,000 1982 Harley-DavidsonHarley-Davidson · Raleigh, NC----+One beautiful ride. Sturgis FXB-80 Twin-Belt this motorcycle was found after 30 years of storage and lovingly and painstakingly, reb...Affes S. · 1 week ago
$1,000 1982 Harley-Davidson FLT TouringHarley-Davidson · Pompano Beach, FLYear: 1982 Make: Harley-Davidson Model: FLT Type: Touring VIN: 1HD1DAK19CY502028 Color: RedK J. · 1 week ago
$750 1982 CM45E Honda Motor CycleHonda · Manhattan, NYThis bike has been stored for several years and needs tires, fluids, hoses and a little TLC. It has 3,191 original miles , basically neve...Tink B. · 2 weeks ago
$3,300 1982 Ducati 600 Sl Pantah Excellent Condition Rare and UnmolestedDucati · Medford, ORRARE 1982 DUCATI 600SL PANTAH MOTORCYCLE ,EXCELLENT CONDITION ,RUNS PERFECT ,EVERTYTHING WORKS ,VERY LOW PRODUCTION ,MINT CONTI PIPES ,36...Postid453 S. · 2 weeks ago
$5,000 1982 Honda CB 900 F SUPER SPORTHonda · New York, NY1982 CB 900 F SUPER SPORT in pristine condition. 17,052 miles. Always serviced by Honda dealer. Valves were recently adjusted,Cam tension...Chria R. · 2 weeks ago
$5,400 1982 Honda CX500 TurboHonda · Seminole, FL… In that time I have put 880 miles on it. Currently it has 8039 miles on it.This bike is all original with the exc...Chris R. · 2 weeks ago
$11,500 motorcycleTrinidad, CO1982 Harley Davidson Super glide II mint conditionSteve S. · 3 weeks ago
$6,500 1982 Ducati 900 original PaintDucati · Jackson, MS@@82 Ducati 900 Super Sport. She is in excellent original condition. Starts easily, runs good, shifts smoothly, handles like on rails, th...Fintich M. ·1 listing · 2 weeks ago
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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Newegg.com - Computer Parts, Laptops, Electronics, HDTVs, Digital Cameras and More!
Brand new and high quality;
Compact, Pocket-sized design;
Provide USB 2.0 high speed interface;
Supports Windows 2000/XP/Vista/Win7;
Perfect solution for small office and home;
Ideal for Internet surfing and online gaming;
300Mbps high performance transmission rates;
Seamlessly compatible with 802.11b/g/n devices;
Simple installation and adaptability and strong security;
Provide two methods of operation: Infrastructure and Ad-Hoc;
Supports 64/128/-bit WEP, complies with 128 bit WPA standard (TKIP/AES);
External detachable omni-directional Antenna provides stronger and more stable signal.
Color: Black;
Net weight: 40g;
Interface: high speed USB 2.0;
Frequency range: 2.4-2.4835GHz;
Wireless standards: IEEE 802.11n(draft),IEEE802.11G,IEEE802.11B;
Chipset: realtek8191;
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Antenna type: integrated antenna;
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Are you Dirk Menche?Claim your profile
Publications (60)299.44 Total impact
Article: Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.[Show abstract] [Hide abstract]
ABSTRACT: The macrolide archazolid inhibits vacuolar-type H(+)-ATPase (V-ATPase), a proton-translocating enzyme involved in protein transport and pH regulation of cell organelles, and potently suppresses cancer cell growth at low nanomolar concentrations. In view of the growing link between inflammation and cancer, we investigated whether inhibition of V-ATPase by archazolid may affect primary human monocytes that can promote cancer by sustaining inflammation through the release of tumor-promoting cytokines. Human primary monocytes express V-ATPase, and archazolid (10 to 100nM) increases the vesicular pH in these cells. Archazolid (10nM) markedly reduced the release of pro-inflammatory (TNF-α, interleukin-6 and -8) but also of anti-inflammatory (interleukin-10) cytokines in monocytes stimulated with LPS, without affecting cell viability up to 1000nM. Of interest, secretion of interleukin-1β was increased by archazolid. Comparable effects were obtained by the V-ATPase inhibitors bafilomycin and apicularen. The phosphorylation of p38 MAPK and ERK-1/2, Akt, SAPK/JNK or of the inhibitor of NFκB (IκBα) as well as mRNA expression of IL-8 were not altered by archazolid in LPS-stimulated monocytes. Instead, archazolid caused endoplasmic reticulum (ER) stress response visualized by increased BiP expression and accumulation of IL-8 (and TNF-α) at the ER, indicating a perturbation of protein secretion. In conclusion, by interference with V-ATPase, archazolid significantly affects the secretion of cytokines due to accumulation at the ER which might be of relevance when using these agents for cancer therapy.Biochemical pharmacology. 08/2014;
- [Show abstract] [Hide abstract]
ABSTRACT: Covering: the literature up to 2012This review presents recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides. These include a novel domino reaction, based on a combination of a nucleophilic addition and a Tsuji-Trost reaction, an innovative sequence relying on an oxidative diyne cyclization and regioselective opening, as well as sequential cross coupling strategies. The design and scope of these methods are discussed and applications in complex target syntheses presented.Natural Product Reports 12/2013; · 10.18 Impact Factor
Article: ChemInform Abstract: Stereochemistry and Total Synthesis of Complex Myxobacterial MacrolidesChemInform 10/2013; 44(42).
- [Show abstract] [Hide abstract]
ABSTRACT: A highly convergent total synthesis of the potent polyketide macrolide rhizopodin has been achieved in 29 steps by employing a concise strategy that exploits the molecule's C2 symmetry. Notable features of this convergent approach include a rapid assembly of the macrocycle through a site-directed sequential cross-coupling strategy and the bidirectional attachment of the side chains by means of Horner-Wadsworth-Emmons (HWE) coupling reactions. During the course of this endeavor, scalable routes for synthesis of three main building blocks of similar complexity were developed that allowed for their stereocontrolled construction. This modular route will be amenable to the development of syntheses of other analogues of rhizopodin.Chemistry 10/2013; · 5.93 Impact Factor
Article: ChemInform Abstract: Construction of Multisubstituted Tetrahydropyrans by a Domino Oxa-Michael/Tsuji—Trost Reaction.[Show abstract] [Hide abstract]
ABSTRACT: Pd-catalyzed treatment of unsaturated alcohols of type (I) with nitro olefins provides a new and efficient approach to multisubstituted tetrahydropyrans, which are of synthetic and biological interest.ChemInform 06/2013; 44(23).
Article: Salimabromide: Unexpected Chemistry from the Obligate Marine Myxobacterium Enhygromxya salina.[Show abstract] [Hide abstract]
ABSTRACT: Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis/Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven-membered cyclic moiety. The absolute configuration was deduced from experimental and calculated CD data. Salimabromide revealed antibiotic activity towards Arthrobacter cristallopoietes.Chemistry 05/2013; · 5.93 Impact Factor
Article: Stereoselective Synthesis of the Butyrolactone and the Oxazoline/Furan Fragment of Leupyrrin A1.[Show abstract] [Hide abstract]
ABSTRACT: Stereoselective syntheses of the Northern and the Southern fragments 2 and 3 of leupyrrin A1 are reported. The convergent preparation of 2 is highlighted by a zirconocene-mediated one-pot cyclization-regioselective opening of an advanced diyne while the route to 3 involves a Krische allylation and a one-pot Sharpless dihydroxylation-cyclization. Comparison of the spectroscopic data with those reported for the natural product supports a relative stereochemical assignment within these heterocycles.Organic Letters 05/2013; · 6.14 Impact Factor
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ABSTRACT: A concise total synthesis of dysidavarone A possessing the new "dysidavarane" carbon skeleton has been accomplished by a convergent strategy, involving a stereoselective reductive alkylation of a Wieland-Miescher type ketone under Birch conditions and an advantageous intramolecular palladium-catalyzed α-arylation of a sterically hindered ketone. Dysidavarone A showed potent antimicrobial and antiproliferative activities based on characteristic morphological changes of treated cells.Organic Letters 02/2013; · 6.14 Impact Factor
Article: Stereoselective Synthesis of 1,3-anti Diols by an Ipc-Mediated Domino Aldol-Coupling/Reduction Sequence.[Show abstract] [Hide abstract]
ABSTRACT: A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate β-hydroxy-ketone. The sequence proceeds with excellent anti-selectivities and enables the rapid construction of complex polyketide fragments.Organic Letters 12/2012; · 6.14 Impact Factor
Article: Highly regioselective opening of zirconacyclopentadienes by remote coordination: concise synthesis of the furan core of the leupyrrins.[Show abstract] [Hide abstract]
ABSTRACT: An efficient protocol for the highly regioselective opening of aliphatic zirconacyclopentadienes is reported. The one-pot process involves a zirconocene-mediated cyclization of 1,6-diynes and highly selective cleavage of the metallacycles with NBS and enables a concise synthesis of the tetrahydrofuran-core of the leupyrrins.Chemical Communications 12/2012; · 6.38 Impact Factor
Article: Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.[Show abstract] [Hide abstract]
ABSTRACT: An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities.Organic & Biomolecular Chemistry 11/2012; · 3.57 Impact Factor
Article: Concise Synthesis of the Macrocyclic Core of Rhizopodin by a Heck Macrocyclization Strategy.[Show abstract] [Hide abstract]
ABSTRACT: A highly convergent synthesis of the central dimeric core of the potent antibiotic macrolide rhizopodin is reported. Notable features of the highly concise route include an effective preparation of the key C8-C22 building block based on an Iridium-catalyzed Krische allylation and a chemoselective cross-coupling approach toward the macrocycle involving a highly advantageous Heck reaction for macrocyclization.The Journal of Organic Chemistry 11/2012; · 4.56 Impact Factor
Article: Full Stereochemical Determination of Ajudazols A and B by Bioinformatics Gene Cluster Analysis and Total Synthesis of Ajudazol B by an Asymmetric Ortholithiation Strategy[Show abstract] [Hide abstract]
ABSTRACT: The stereochemical determination of the potent respiratory chain inhibitors ajudazols A and B and the total synthesis of ajudazol B are reported. Configurational assignment was exclusively based on biosynthetic gene cluster analysis of both ketoreductase domains for hydroxyl-bearing stereocenters and one of the first predictive enoylreductase alignments for methyl-bearing stereocenters. The expedient total synthesis resulting in unambiguous proof of the predicted stereochemistry involves a short stereoselective approach to the challenging isochromanone stereotriad by an innovative asymmetric ortholithiation strategy, a modular oxazole formation, and a late-stage Z,Z-selective Suzuki coupling.Journal of the American Chemical Society 11/2012; 134(47):19362–19365. · 10.68 Impact Factor
Article: Construction of Multi-substituted Tetrahydro-pyrans by a Domino oxa-Michael/Tsuji-Trost Reaction.[Show abstract] [Hide abstract]
ABSTRACT: Biologically significant tetrahydropyrans (THP) were concisely synthesized by a Tandem Oxa-Michael/Tsuji-Trost reaction. Different Michael acceptors were investigated and optimal results in terms of diastereoselectivities and yields obtained with nitro olefins. The influence of the reaction parameters, substrate patterns and type of metal counter ions on the yield and stereochemical outcome of this process is discussed and an explanation for the observed stereoselectivities is proposed.The Journal of Organic Chemistry 11/2012; · 4.56 Impact Factor
Article: Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid.[Show abstract] [Hide abstract]
ABSTRACT: The water-solubility of the highly potent V-ATPase inhibitors archazolid A and the glucosylated derivative archazolid C was studied in the presence of a wide range of cosolvents, revealing very low solubilites. The first water-soluble analogue was then designed, synthesized, and evaluated for V-ATPase inhibitory activity in vitro.Bioorganic & medicinal chemistry letters 10/2012; · 2.65 Impact Factor
Article: Kurze Synthese von Acetal-geschützten 1,3-syn-Diolen durch einen Tandemprozess aus Halbacetalbildung und Tsuji-Trost-Reaktion[Show abstract] [Hide abstract]
ABSTRACT: Eine neue Dominosequenz ermöglicht den schnellen Aufbau von Acetal‐geschützten 1,3‐syn‐Diolen. Wie in einer konvergenten Synthese eines Polyolfragments aus dem Makrolid‐Antibiotikum RK‐397 gezeigt, öffnet das Verfahren einen schnellen und stereoselektiven Zugang zu Diol‐Motiven, die in Polyketiden vorkommen.Angewandte Chemie 09/2012; 124(37).
Article: Concise Synthesis of Acetal-Protected syn 1,3-Diols by a Tandem Hemiacetal Formation/Tsuji-Trost Reaction.[Show abstract] [Hide abstract]
ABSTRACT: Designed, developed, and applied: A novel domino sequence was used for the rapid assembly of acetal-protected syn 1,3-diols. The convergent synthesis of a polyol fragment of the macrolide antibiotic RK-397 demonstrates that this method is suitable for the rapid and stereoselective preparation of polyketide-type diol motifs.Angewandte Chemie International Edition 08/2012; 51(37):9425-7. · 11.34 Impact Factor
Article: Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien.[Show abstract] [Hide abstract]
ABSTRACT: Novel simplified side chains of the potent RNA polymerase inhibitor etnangien were designed, synthesized and evaluated for antibacterial activity against Gram-positive bacteria and one Gram-negative bacterium.Bioorganic & medicinal chemistry letters 07/2012; 22(17):5731-4. · 2.65 Impact Factor
Article: Efficient synthesis of diverse hetero-bis-metallated alkenes as modular reagents towards highly conjugated and isolated olefinic systems.[Show abstract] [Hide abstract]
ABSTRACT: An efficient synthesis of diverse hetero-bis-metallated alkenes with conjugated and isolated olefin subunits is reported. Relying on those useful tin/boron reagents a convergent, palladium-catalyzed fragment coupling strategy has been developed as an elegant methodology to construct highly conjugated polyenes and stabilized olefinic analogues thereof. The utility of these reagents was further demonstrated in a concise and modular construction of extended polyene side chains of the potent polyketide antibiotic etnangien.Chemical Communications 07/2012; 48(66):8267-9. · 6.38 Impact Factor
Article: Understanding the inhibitory effect of highly potent and selective archazolides binding to the vacuolar ATPase.[Show abstract] [Hide abstract]
ABSTRACT: Vacuolar ATPases are a potential therapeutic target because of their involvement in a variety of severe diseases such as osteoporosis or cancer. Archazolide A (1) and related analogs have been previously identified as selective inhibitors of V-ATPases with potency down to the subnanomolar range. Herein we report on the determination of the ligand binding mode by a combination of molecular docking, molecular dynamics simulations, and biochemical experiments, resulting in a sound model for the inhibitory mechanism of this class of putative anticancer agents. The binding site of archazolides was confirmed to be located in the equatorial region of the membrane-embedded V(O)-rotor, as recently proposed on the basis of site-directed mutagenesis. Quantification of the bioactivity of a series of archazolide derivatives, together with the docking-derived binding mode of archazolides to the V-ATPase, revealed favorable ligand profiles, which can guide the development of a simplified archazolide analog with potential therapeutic relevance.Journal of Chemical Information and Modeling 07/2012; 52(8):2265-72. · 4.30 Impact Factor
Top Journals
University of Bonn
Bonn, North Rhine-Westphalia, Germany
- Kekulé Institute of Organic Chemistry and Biochemistry
Universität des SaarlandesSaarbrücken, Saarland, Germany
Heidelberg UniversityTiffin, Ohio, United States
Universität Heidelberg
Heidelberg, Baden-Wuerttemberg, Germany
- Institute of Organic Chemistry
Helmholtz Centre for Infection Research
Brunswyck, Lower Saxony, Germany
- Department of Chemical Biology (CBIO)


text:
Are Cruisers OK for Tac Captains?
View Single Post
Archived Post
Lt. Commander
Join Date: Dec 2007
Posts: 120
# 121
Originally Posted by
Captain Data
I think 4 teams a little much, and I run EPtS3 with 2 EPtW, I run DEM2 and DEM3 with one ET, to make up for the lack of a 2nd EPtS I use shield Batteries and RMC. I prefer the Aegis set over the Borg.
Well.. I chose the Borg set (minus shield) because the regen buffs are nice for a DPS cruiser.. I was a little concerned about losing the defense and resists, but it seems to work nicely.
As for the ep2x.. They chain perfectly.. Rarely drop below 100 weaps, and shield is constantly at high power..
But hey... Whatever works, right


text:
"Do you carry the New Yorker digitally?" "When are you going to get Wired online?" FINALLY, we can respond "YES!", "and "NOW"! With Zinio, our popular e-magazine platform highlighted in a blog post last June by Magazine & Newspaper Librarian Kirsten Baldock, Oakland Library cardholders can download and keep digital editions of the current issues of popular magazine titles, now including Condé Nast magazines! Since OPL began subscribing to Zinio over a year ago, patrons have been asking for many of these formerly-not-available-to-libraries titles. Condé Nast and Zinio struck a deal this fall, and our patrons now have access to (drum roll):
Starting October 6th, we will no longer mail hold pick/cancellation notices. In order to receive information about your holds, please log in to Your Library Account and make sure we have your current email address or phone number. Thank you for your cooperation.


text:
'Awesome features!'
'Excellent high-resolution LCD screen'
'Feels great in the hand, Awe-inspiring zoom'
'Feature packed, Good zoom range, Decent image quality'
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'Sharp results shooting handheld even at the far reaches of the zoom'
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'Weather-sealed body that's unique in its price class'
'Large pentaprism viewfinder, Weather-sealed design'
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'Excellent value for money'
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'Top Notch Entry Level Camera w/ Advanced Features'
'5.5FPS continuous shooting speed puts it above competition'
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'Reproduction of details in distant objects is poor'
'Powerful 50x optical zoom, Captures in RAW, Good low-light photos'
'Menu system could be better'
'This is a great camera'
'Excellent OLED electronic viewfinder'
'Picture Effects, Low light performance'
'Comfortable handgrip and handling'
'Good image quality'
'Delivers responsive autofocus while recording video'
'Good levels of detail, Comfortable handgrip'
'Very good photo quality'
'Good quality at high ISOs'
'Good video and images'
'Snappy performance when shooting with the viewfinder'
'Highest-resolution APS-C DX format Nikon DSLR,'
'24 Megapixel CMOS sensor'
'Well-balanced noise reduction at higher sensitivities, decent noise levels'
'Excellent guide mode, 24MP sensor, Full HD video'
'Excellent image quality'
'Fast shooting performance, even when shooting in raw or raw plus JPEG'
'Excellent EVF, Hot shoe and mic input'
'Appealing to sports and nature photographers'
'Raw capture, Lots of direct controls'
'Autofocus performance is stunning'
'Feature packed, Good image quality'
'Vari-angle screen, decent battery life, raw file capture available'
'Superb lens sharpness'
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text:
27 Better Ways To Eat Ramen
It should be its own food group.
It should be its own food group.
Arielle Calderon a year ago 407 responses
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text: 500 pts Break.com Trivia <Newsmembers The following video shows a guy doing push ups while solving what? Click here for the answer. Sign in to Participate Category: Trivia Ends: Monday October 15 at 8:59PM PDT Visit our sponsor: Click here for the answer! Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! More Ways To Get and Use Points Live in Hawaii or NYC?What Do You Cook Day Before?Play Battle of the Sexes!Newsletter Bonus Word for Thanksgiving WeekBest Thanksgiving Food?Newstalk VIP Winning Words for 11-24–11-28 Brought to You by Legacy One Insurance


text:
The recent decline in commodity prices (oil and metals are down 8.4 and 4.7 percent in the last month) attests to the possibility that commodity prices come down sharply in the projection period. The price rises of the past decade reflect the influence of a wide range of factors (see the 2009 edition of Global Economic Prospects http://go.worldbank.org/G8LVQDRH70 for a detailed discussion), but may have reached unsustainable levels.
Notwithstanding the sharp declines in May, since 2000, oil prices have increased by 268 percent, metals and minerals prices by 245 percent and agricultural prices by 165 percent. While demand for these products can be inelastic in the short run, such large price swings unleash very powerful economic forces, in the form of substitution on the demand side, increased supply (via increased exploration and investment), and technological change.
All of these forces are at work currently (see box Comm.1 in the commodity annex), most obviously in the energy sector where OECD oil demand has declined 8 percent over the past 5 years, and where new technologies (such as shale gas and liquids extraction techniques) have brought large new supplies to market. These new supplies have opened up large and potentially destabilizing price differentials between natural gas and crude oil (figure 19) that could contribute to a longer-term fall in oil and other commodity prices.
If commodity prices were to come off their current highs there could be potentially serious consequences for the external and internal imbalances of commodity exporting economies, who depend upon commodity revenues to finance a large share of their imports and government expenditures.
Table 5 reports the simulated impact on developing country commodity exporters of a 20 percent decline in commodity prices. The first three columns of the first set of simulations show the impact on: the level of GDP (after two years); the government balance as a percent of GDP; and the current account balance as a percent of GDP, under the assumption that oil prices fall by 20 percent and that other commodity prices fall according to their own sensitivities to the fall in oil prices (oil prices are an important determinant of other commodity prices). The fourth through sixth columns report the impacts from a simulation that assumes oil prices do not change, but that other commodity prices decline by 20 percent.
In the first set of simulations, alternative financing is assumed to be found so that the government revenue shortfalls caused by the crisis are made up for via borrowing (external or domestic). In the second set of results, revenue shortfalls are assumed to be binding such that government expenditure must be cut by the decline in government revenues from the earlier simulation.
In the first scenario government deficits rise by close to 1 percent of GDP in the Middle-East and North Africa because of lower oil prices. However, GDP effects are relatively small —in part because the government is assumed to continue to maintain spending at earlier levels via increased borrowing. Impacts in the non-oil commodity price simulation are smaller because these commodities tend to be much less important sources of revenue for governments at the aggregate level.
In the second set of results, all of the lost government revenues from the first are assumed to be deducted from government spending. Here GDP effects are much larger, but because of demand compression current account effects are more muted. Impacts for individual countries are of course larger, with GDP in Paraguay, Uruguay, Argentina, Kyrgyz Republic, Belize, Chile, and Uzbekistan (all important extractive commodity exporters or countries with close links to commodity exporters) projected to decline relative to baseline by more than 2 percent in the non-oil with government budget constraint scenario.


text:
In the light of the recent Rubygems.org security compromise the community has been looking at ways to make Rubygems.org and Ruby gems in general more secure. The project is still ongoing and feel free to help them out on #rubygems on Freenode, but here is a highlight of what I think are some of the main issues.
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Feb 04 2013 / 08:28


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Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
Prep Time:
Cook Time:
15 mins
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A simple list of ingredients turns into a wonderfully moist flavorful cake. Dress it up or down with equal success...I prefer a ganache filling and a citrus cream cheese frosting.
Units: US | Metric
Serving Size: 1 (133 g)
Servings Per Recipe: 16
The following items or measurements are not included:
lime zest
Every recipe, menu, tip and how-to is right here, at your service.


text:
Thanks for the info. on the NYC Uhlfelders. I'm assuming that Rosetta Uhlfelder was my Great Grandmother. Do you know anything more about her in particular? Thanks, Russ Frey P.s. I've been waiting for info. from Ron for quite awhile.
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UtilX Team by SE UtilX Team - almost 2 years ago
"Annual training in Miami in our new shirts for the customer Holiday Cards" view full details
Keyz and Meek Mill by Keyz Da Don - almost 2 years ago
"This photo was taken of Rapper Meek Mill and I in the studio in Miami while working on his debut album "dreams and nightmares". I (left) am wearing a shirt made by custom ink with a design I create..." view full details
MillionDollarDreams by @flymoneyfresh - about 2 years ago
"Halloween Night In Miami, Fl (Cocowalk) Supporting the movement, anythings possible and everybody dreamed about being a millionaire. My experience with customink was the best they are professional ..." view full details
Having fun @ E2M by Nicaraguan runners - about 2 years ago
"Escape to Miami Triathlon water station two and four" view full details
Carb Busters: Walk to STOP Diabetes 2012 by Carb Busters - about 2 years ago
"Step Out Miami 2012: Walk to STOP Diabetes. September 22, 2012 held at the Marlins Park. CustomInk was a pleasure to work with. We will definitely be designing and ordering more shirts from Cus..." view full details
DF in NvsS Orlando Tournament by DADEZ FINEST - over 2 years ago
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Diamond Girls and Varsity 2011 of Coral Reef Miami by Coral Reef Barracuda Baseball 2011 - over 3 years ago
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text:
The Leading eBooks Store Online
for Kindle Fire, Apple, Android, Nook, Kobo, PC, Mac, BlackBerry ...
When Anger Hurts
Quieting the Storm within
Not available
A major revision of the best-selling classic — a quarter of a million copies sold.
This new edition of When Anger Hurts is a complete, step-by-step guide to changing habitual anger-generating thoughts while developing healthier, more effective ways of meeting your needs. It includes new chapters on emergency anger control, the interpersonal and physiological costs of anger, road rage, and parental anger.
- Discover how to create your own personal intervention strategy for controlling angry impulses
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When you work through the exercises and lessons in this book, you will immediately see positive change in every aspect of your life.
New Harbinger Publications; Read online
Title: When Anger Hurts
Author: Matthew McKay; Peter D. Rogers; Judith McKay
Title: When Anger Hurts
Author: Matthew McKay; Peter D. Rogers; Judith McKay
Buy, download and read When Anger Hurts (eBook) by Matthew McKay; Peter D. Rogers; Judith McKay today!
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Manology 2013 US$ 10.93 288 pages
Act Like a Lady, Think Like a Man, Expanded Edition 2014 US$ 10.99 288 pages
A Lily Among the Thorns 2007 US$ 21.95 226 pages
How To Win Friends and Influence People 2010 US$ 11.66 320 pages
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text:
Ruská Bystrá
From Wikipedia, the free encyclopedia
Ruská Bystrá is a village and municipality in the Sobrance District in the Košice Region of east Slovakia.
In historical records the village was first mentioned in 1405.
The village lies at an altitude of 453 metres and covers an area of 11.965 km². It has a population of 130 people.
The village has a public library
External links[edit]
Coordinates: 48°51′N 22°18′E / 48.850°N 22.300°E
|This Košice Region geography article is a stub. You can help Wikipedia by expanding it.


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Rural electric experts to weigh in on changing utility landscape
Send this to a friend
- Andy Giegerich
- Digital Managing Editor- Portland Business Journal
- Email | Twitter | Google+
Rural electric cooperatives, as well as "disruptive technologies" that affect them, will get a closer look during a Thursday panel.
The event, which includes Umatilla Electric Cooperative CEO Steve Eldridge, seeks to demonstrate ways in which electric cooperatives are "far ahead of the rest of the industry in the deployment of advanced smart meters," according to a National Rural Electric Cooperative Association release on the event.
To that end, the discussion will address how utilities are now procuring large amounts of data on customer usage, how they can help members overcome barriers to energy efficiency and how social media is changing the small utility world.
Joining Eldridge are the NRECA's Martin Lowry, Midwest Energy Cooperative's Ernie Lehman and consultant Greg Boudreaux.
The Oct. 17 event starts at 9:30 a.m. at the Portland Hilton and Executive Towers.
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Southeast Michigan Events & Attractions
Art & Apples Festival
Paint Creek Center for the Arts hosts this juried art show with kids activities, food and more Sept. 9-11, 2011.
|September 2011
Plymouth Fall Festival
Year 56 of this annual community event happening in downtown Plymouth promises fun for the whole family Sept. 9-11, 2011
|September 2011
Astronomy at the Beach
This family fun nighttime event returns to Kensington Metropark in Milford Sept. 9-10, 2011.
|September 2011
Detroit Jazz Festival 2011
Kids are encouraged to bop to the beat Sept. 3-5 at this Labor Day event.
|September 2011
Peach Festival in Romeo
This annual Macomb County event celebrates its 80th birthday and promises family fun Sept. 1-5, 2011.
|August 2011
Arts, Beats & Eats in Royal Oak
Downtown Royal Oak hosts live bands, an art show and food from local restaurants at this family fun event Labor Day weekend, Sept. 2-5, 2011.
|August 2011
2011 Voyageur Encampment
Metro Beach Metropark in Harrison Township welcomes families Aug. 27-28, 2011 for some historical fun.
|August 2011
Chelsea Community Fair
The city of Chelsea comes together for five days of family fun during this 74th annual event, happening Aug. 23-27, 2011.
|August 2011
Warren Birthday Bash
The city of Warren serves up art, food, tunes, fireworks and more free family fun at City Square Aug. 25-28, 2011.
|August 2011
Family Market Day
On Aug. 27, 2011, the Oakland County Farmers Market hosts one full Saturday of free family fun, from great food to yoga!
|August 2011


text:
Harrah's hosts poker World Series
The 2010-2011 World Series of Poker® Circuit Events return to Harrah's Tunica starting January 27, 2011.
The eighth stop of the 2010-2011 season, the WSOP Circuit Events at Harrah's Tunica will consist of ten ring events and offer a variety of poker events that range from $100 (+$20) buy-ins to $500 (+$55) buy-ins including: No Limit Hold'em, Omaha 8 or Better, 6-Handed No Limit Hold'em, Seniors No Limit Hold'em, and the $1,500 (+$100) buy-in Harrah's Tunica Main Event Championship. The Main Event Championship begins February 13 and is a three day structured event. The winner of the Main Event will receive a buy-in to the 2011 World Series of Poker in Las Vegas.
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China Mobile's 4G Explosive Growth Is Positive For Apple
China Mobile is experiencing amazing 4G growth in its customer base which if positive for Apple. read »Chuck Jones, Contributor
China Mobile is experiencing amazing 4G growth in its customer base which if positive for Apple. read »Chuck Jones, Contributor
Earlier today, Scott Stapp who fronted the band "Creed" in its heyday, posted a bizarre video on his Facebook page claiming that he is now penniless and living in a Holiday Inn. Denouncing claims that he might be on drugs, Stapp places the blame for his predicament on a number of others, including the IRS, who he says froze his accounts on a read »Kelly Phillips Erb, Contributor
The minimum wage is one of those topics which tends to create a lot of attention. Those in favor argue that it will help the economy. Those opposed say it will hurt small businesses. Raise it? Keep it the same? What's the best decision? Find out in this article. read »Mike Patton, Contributor
Myanmar digital startup NEX has won second round funding of US$150,000 from Singapore's Blibros Group, the privately-held investment arm of Sweden's Böcker family. Yes, this is the family of Magnus Böcker, CEO of the Singapore Exchange and former CEO of Nasdaq OMX Nordic. NEX got its initial angel investment of read »Susan Cunningham, Contributor
I did something really scary. My soul's desire to go back to freelancing finally overpowered my need an infinite stream of paychecks, a cadre of charming coworkers, and all the Tazo tea I could drink in a day. I sat down with my manager, stammering as I told her, "I have some news …" and then quit, giving a month's cushion to tie up and read »Vanessa McGrady, Contributor
Venezuela is trying to herd the cats towards production cuts, while Saudi Arabia is herding them towards status quo. $100 oil is a tasty cat treat, but Saudi Arabia is the big dog of the organization.
Mick Jagger said, "You can't always get what you want, but if you try sometimes, you just might find, you get what you need." read »Michael Lynch, Contributor
Merry-Go-Round Playhouse Inc operates a professional summer stock theater in Auburn, New York. MGRP recruits actors and staff from all over the country. Given the short term nature of the gig and the low pay, MGRP needs to provide the aspiring thespians with housing. This had been handled by leasing apartments with local read »Peter J Reilly, Contributor
In the latest look at stocks ordered by largest market capitalization, Russell 3000 component Owens Corning (NYSE: OC) was identified as having a larger market cap than the smaller end of the S&P 500, for example Bemis Co Inc (NYSE: BMS), according to The Online Investor. Click here to find out the top S&P 500 components ordered by read »Dividend Channel, Contributor
In the latest look at the underlying components of the S&P 500 ordered by largest market capitalization, Time Warner Inc (NYSE: TWX) has taken over the #61 spot from Morgan Stanley (NYSE: MS), according to The Online Investor. Click here to find out the top S&P 500 components ordered by average analyst rating »
Market read »Dividend Channel, Contributor
The most recent short interest data has been released by the NASDAQ for the 11/14/2014 settlement date, which shows a 7,131,467 share decrease in total short interest for Chimera Investment Corporation (NYSE: CIM), to 14,018,243, a decrease of 33.72% since 10/31/2014. Total short interest is just one way to look at short data; another metric read »Dividend Channel, Contributor


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Posts by psycx
2 posts • joined 6 May 2007
O2 starts charging for calls to non-places
pac codes on their way
...for two contracts. One of which upgraded in April and the other early August. On the latter there was 17 months left on it! The Blackberry will be kept.
I told them:
That bundled minutes for 08xx numbers was given to me as an adavantage of staying with O2 by the retention department at CPW when I rang to cancel earlier in the year.
I intended to use 08xx to call international service providers to get cheaper rates - brother just moved abroad.
However, they wouldn't cancel unless they found use of these numbers in the last few months, which we had.
Poisonous spiders invade Britain
In my house!
One of these nearly bit me last week. When I walked into my dining room, I saw something in the corner of my eye and it was one of these in the middle of the room suspended by a single strand of silk in mid air.
Eventually it climbed up, but when I moved it went back down again and dropped on the floor.
At this point, it didn't last very long.
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1. Check the restrictions on the DL and see if user are required to be authenticated.
2. What error do you get or NDR?
Having created a Year 7 distribution group on Outlook Live [Live@Edu] I find that our staff cannot send to this list [Our staff are not on Live@Edu but on our own Exchange server and on a separate domain]
Does anyone else have a similar setup?
Has anyone else solved this problem?
I ask because looking at 'Domains & Protection' only tells me that the domain is hosted with no other configuration options available.
1. Check the restrictions on the DL and see if user are required to be authenticated.
2. What error do you get or NDR?
I am guessing that our staff are not allowed to E-Mail the distribution list I have created [despite them being able to send to individuals or a number of individuals as a list]#< #5.7.1 smtp;550 5.7.1 RESOLVER.RST.AuthRequired; authentication required>
Do I need to be able to set the permissions for the distribution list? If I do how do I do that without access to the Exchange server that drives/controls this?
1. Yes, you need to set permission for staff to be able to send. You can either remove authentication or set it.
2. To remove you must have access to the live@edu console right,
1. Click the Distribution Group name as you want to set
#2. Click the "Properties"
#3. Click the "Mail Flow Settings" Tab
#4. Click the "Message Delivery Restrictions" item
#5. Click the "Properties..." button
#6. Uncheck the "Require that all senders are authenticated" item
#7. Click "OK" button
#8. Click "OK" button again
Click on the users and groups and find the DL
DaveP (13th July 2011)
Sorted now. Not the most intuitive interface I feel. Also I have to allow all mail to go through to get this to work.
Nevertheless what we have now is a start. Thanks again.
Yes. I would have liked to restrict the students to only receive E-Mail from their peers and our teachers [to prevent spam, Viagra ads and the like getting through]
I had hoped that over time I could relax, but not remove, the blocks. However what we have is all or nothing.
Your MX records, where are they poiting, surely most of this would be picked up by the AV/AS your using?
Also, if you want, instead of removing authenticated users, what you can do is create another DL. Create contacts for your staff, then add these contacts to the DL, specify that DL so message are only received from those in the DL. You can if you wish ass the students to that DL too.
This way only users/contacts in that DL can send to that DL.
There are currently 1 users browsing this thread. (0 members and 1 guests)


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<quoted text>So now you're suggesting we pay them for the tragedies their forefathers endured? Then who's going to pay us for the tragedies of slavery that our European forefathers endured in Africa back in the day? Do some research, the number of European slaves in Africa far outnumber the amount of black slaves in the states.
Indentured servants or slaves? Indentured servants had a time period as slaves until the debt was paid in full. Slaves from Africa were in bondage for life. Which one do you mean for European slaves?


text:
wait... seriously?
makers mark tastes like motor oil
Need A Whiskey To Boycott?
Filed under:
wait... seriously?
talk to caris yo
he grew a beard
if it's not a pig or a farm implement or a weird thing it ain't a trophy
transition is de-emphasized across the NCAA, for better or worse
hooray this is relevant--site will be the new Wings Arena.
Reader Nick Walstra provides a picture of this enormous Columbus-area billboard analogue for your general disgust:
Next time you're strolling the aisle looking for a libation, suggest you skip the Maker's Mark.


text:
Album 58
Köln with La Sardina (thanks spoeker), Agfa CT Precisa, xProThis photo was shot on film. Taken by das-z with a Lomography La Sardina loaded with Agfa CT Precisa 100 (35mm) film (available in our Online Shop) in Köln, Germany. These tags describe this photo: das-z, cologne, first test, thanks spoeker, homestory, cross, köln, indoor, flash, xpro, and la sardina. Date: 2011-06-18. Time: Dusk. This photo can also be found in the album 58# Köln with La Sardina (thanks spoeker).
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Chairman Darrell Issa sent a letter to Attorney General Eric Holder asking him to submit a proposal for how he intends to comply with the Committee's subpoena in an effort to facilitate an agreement rendering the process of contempt unnecessary.
Chairman Darrell Issa issues a statement on CBS News winning the Edward R. Murrow Award for Investigative Reporting on Operation Fast and Furious.
On June 20th, the Oversight Committee will meet to consider a report holding Attorney General Eric Holder in contempt of Congress for his failure to produce subpoenaed documents related to Operation Fast & Furious.
House Oversight and Government Reform Committee Chairman Darrell Issa confronted Attorney General Eric Holder with new documents showing that senior Justice Department Officials in Washington were given specific information about reckless tactics in Operation Fast and Furious.
House Oversight Committee Chairman Darrell Issa urges the Department of Labor to not dramatically alter the way jobs and employment data are reported to the public.
The House Committee on Oversight and Government Reform will hold a hearing next Wednesday to examine the influence of Department of Labor political appointees over the Bureau of Labor Statistics processes for collecting and disseminating employment data.
The House Committee on Oversight and Government Reform will conduct two hearings Thursday to assess the Obama Administration's record in implementing a domestic energy production program.
"It is suggestive and troubling that more than half a year has passed without DOI providing the requested documents and information. Our concern is heightened given the serious nature of the questions raised and the government's pattern of indiscretion in providing government assistance to politically connected green energy companies such as Solyndra."
"The resignation of Chairman Jaczko will close an ugly chapter and allow the Nuclear Regulatory Commission to focus on its mission – ensuring the safe operations of the nation's nuclear plants," Issa said.
As part of its AmericanJobCreators.com effort to spotlight the impact of government red tape on workers and companies, the House Oversight and Government Reform Committee has contacted nearly 200 organizations seeking their insight on regulations that hurt job creation.


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- For Some Fans, Accusations of Rape Crumble Bill Cosby's Wholesome Image
- Ben McKenzie Returns to New York for 'Gotham'
- New Starts on 'Live Free or Die,' 'Survivor' and 'Utopia'
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Reel Comedy: Semi-Pro
TV Special
More in Television
TV Highlights
What's On This Week
A daily updated summary of the week in TV.
Program Overview
Executive Producer: Troy Miller
Genres: Comedy, Interview
Genres: Comedy, Interview
Program Synopsis
A behind-the-scenes look at the movie "Semi-Pro" featuring clips and interviews with its stars Will Ferrell and Woody Harrelson.
What's On Tonight
- Roll Over, Mahler: U.S. Orchestras Are Shrinking
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- Put Me on TV. I'll Change. I Swear.
- Toward a Truth That Defies Precision


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We are simply over the moon! It is a fantastic result as only 2.9% of all entrants were awarded 2 gold stars and we got 3 of them! A fourth coffee was also awarded gold! This is our 3rd year entering the Great Taste Awards with previous golds in 2012 and 2013 and we are delighted with the results. We entered some of our customer's favourites and it would be fair to say that they have GREAT TASTE too!Read More News »
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Offering an intimate size, Priestville Guest House is great for a getaway. This is a 3-star property. Edinburgh Castle and Craigmiller Castle can easily be reached on foot from the hotel.
Free breakfast is offered to all guests staying in Priestville Guest House. Decide which one of the 6 rooms is best for your stay. If you prefer to drive here, rest assured that you will be able to utilise free self service parking at limited hours.
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A gruesome wake-up call for the United Kingdom.
March 6-8, 2015
Terrenea Resort
Palos Verdes, CA
How Palestinian Nazis speak: Blessed are your axes. palwatch.org/main.aspx?fi=1…
I understand the traitor John Kerry is headed for the UAE to plead with them to remove the terrorist front CAIR from their terrorist list.
Oh yes, and Sharpton is also a crook, which is why he is in financial trouble: nytimes.com/2014/11/19/nyr…


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Though there is an acute water crisis in Whitefield, response to Cauvery Stage IV Phase II that promises regular water supply to a part of the area has been lacking.
Jagadish, a resident of The Grove, a residential colony, said Cauvery water has been a pipe dream since he shifted to the area half a decade ago. Murali, a resident of Vijaynagar, said houses with Cauvery connection scarcely get water and the connection and the fee had made it unfeasible.
Officials with the Bangalore Water Supply and Sewerage Board (BWSSB) said very few had taken the connection. An official who did not want to be named said: "Unless most people in an area avail themselves of a connection, it is difficult even for us to provide water regularly. Not even 300 new connections are being taken a month. There is no revenue being generated to sustain it."


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Does the country really need two Republican responses to President Obama's State of the Union address? That's what voters may be wondering on Tuesday night, when Obama's speech is followed by an official GOP response from Sen. Marco Rubio of Florida and a Tea Party rebuttal from Sen. Rand Paul of Kentucky. You can practically hear the sound of establishment Republicans tearing their hair out, with Paul's unwelcome contribution only underscoring the party's deep divisions on a night when the GOP needs to present a unified, coherent alternative to Obama.
Paul, for his part, insists that his response is not meant to upstage Rubio's. "To me, I see it as an extra response, I don't see it as necessarily divisive," Paul told CNN. "He and I don't always agree, but the thing is, this isn't about he and I, this is about the Tea Party, which is a grassroots movement, a real movement."
Still, Paul's "extra response" will likely contribute to a jarring sense of double vision for voters, as two of the GOP's best-known politicians vie to speak for the country's conservatives. As Steve Benen writes at The Maddow Blog:
What GOP officials want tomorrow night is two competing messages: The president's vision vs. the Republican vision… But there won't be two competing messages: Rand Paul guarantees there will be three. [MSNBC]
Furthermore, both Paul and Rubio are considered top potential contenders for the 2016 Republican presidential nomination, which will only feed a sense that the two men are competing against one another. "Who can talk back at Obama better?" asks Dan Hirschhorn at New York Daily News. "Call it the first showdown of the Republican 2016 presidential primaries — though the Tea Party Express doesn't see it that way."
The tag-team approach to the State of the Union has become something of a tradition for the Republican Party. Rep. Michele Bachmann (Minn.) offered a Tea Party response in 2011, while pizza magnate Herman Cain did the honors in 2012.
But party leaders must be especially frustrated this year, given that Rubio is also a Tea Party favorite, boasting that often elusive mix of bedrock base support and establishment favor. If he can't unite the party, who can?
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Domestic Spying Topics
Democracy Now! stories, posts and pages that relate to Domestic Spying
The One Percent Doctrine: Journalist Ron Suskind on the Deliberate U.S. Bombing of Al Jazeera, Losing Bin Laden and MorePulitzer prize-winning journalist Ron Suskind joins us to discuss his new book, "The One Percent Doctrine: Deep Inside America's Pursuit of Its Enemies Since 9/11." In it, Suskind writes that that the U.S deliberately bombed the Kabul, Afghanistan offices of Al Jazeera in 2001. [includes rush transcript]Jul 14, 2006 | Story
Veteran Journalist Robert Scheer on Playing President: My Close Encounters with Nixon, Carter, Bush I, Reagan and Clinton- and How They Did Not Prepare Me for George W. BushWe speak with veteran journalist and author Robert Scheer about his new book, "Playing President: My Close Encounters with Nixon, Carter, Bush I, Reagan and Clinton- and How They Did Not Prepare Me for George W. Bush." [includes rush transcript]Jul 10, 2006 | Story
Servicemembers Legal Defense Network released documents earlier this week showing that the Pentagon conducted surveillance on a more extensive level than first reported late last year. We speak with the executive director of SLDN and a staff attorney with the American Civil Liberties Union who recently filed a federal lawsuit to force the agency to turn over additional records. [includes rush transcript]Jun 29, 2006 | Story
The Bush administration is lashing out at media outlets for their reports on the government's secret monitoring of international bank transactions without court-approval. We speak with Georgetown law professor Jonathan Turley about Total Information Awareness–he says the program was never really killed. [includes rush transcript]Jun 27, 2006 | Story
Federal Judge Rules U.S. Can Detain Non-Citizens Indefinitely on Basis of Religion, Race or National OriginA federal judge in Brooklyn has ruled the government can legally detain non-citizens on the sole basis of their religion, race or national origin and then detain them indefinitely. We speak with an attorney with the Center for Constitutional Rights that filed a lawsuit in the case. [includes rush transcript]Jun 16, 2006 | Story
German citizen Khaled El-Masri tried to sue the CIA for wrongfully kidnapping and abusing him. But last week, a U.S. District Court dismissed the case on the grounds it would jeapordize state secrets. We're speak El-Masri's attorney, Ben Wizner of the ACLU. [includes rush transcript]May 25, 2006 | Story
General Michael Hayden appeared before Senate Thursday for his confirmation hearings to become the new head of the CIA. The former director of the National Security Agency repeatedly defended the legality of the NSA's secret warrant-less domestic eavesdropping program that he helped design. [includes rush transcript]May 19, 2006 | Story
For the first time since the Sept. 11 attacks, the full Senate and House Intelligence Committees were briefed Wednesday on the National Security Agency's warrantless domestic surveillance program. The Bush administration agreed to allow the briefing to happen with hopes it would pave the way for the Senate Intelligence Committee to approve the nomination of former NSA Director General Michael Hayden to become the new head of the CIA....May 18, 2006 | Story
Ex-NSA Head Bobby Ray Inman on the National Security Agency's Domestic Surveillance Program: "This Activity Was Not Authorized"Admiral Bobby Ray Inman has become the highest-ranking former NSA official to speak out about the domestic spy program. "There clearly was a line in the FISA statutes which says you couldn't do this," said Inman last week in remarks that have received little attention. [includes rush transcript]May 17, 2006 | Story
In the 1970s, the Church Committee, led by Senator Frank Church, conducted a major investigation of the country's intelligence agencies. During its investigation the Church Committee uncovered that several major corporations helped the NSA spy on Americans in a secretive program known as Project Shamrock. Frederick Schwarz, who served as chief counsel to the Church Committee, joins us to look at the similarities with the current NSA spy...May 17, 2006 | Story
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text:
Eric Zuesse A report posted October 15th at Russia Insider (a Russian website), headlined "Russian Industry Expands Rapidly In September, Hammers Expectations: Fastest growth since 2012. Manufacturing up 3.6%. Food production shows double digit growth." This contradicts many reports in U.S. media, ...Read More »
Why Obama Lost His War in Ukraine
Eric Zuesse RINF Alternative News When President Obama took control of Ukraine in February 2014, via a coup d'etat against the democratically elected President, rather than by an outright invasion of U.S. troops, the new Government that he imposed in Kiev ...Read More »
Headlines in the World's Only Great Newspaper
Headlines in the World's Only Great Newspaper: Starting This Past Weekend, Till Today Eric Zuesse Where can one go in order to find honestly reported news in the English language? I have long searched to find the answer to that ...Read More »
Falsehoods in the NYT's Editorial, 'Mr. Putin Tests the West in Ukraine'
Eric Zuesse RINF Alternative News The only way to expose lies is within context; so, this will be somewhat lengthy: The Times editorial opens with a falsehood: "There is no longer any doubt: Russian troops are in Ukraine, not as volunteers, as the ...Read More »
Iraq and the War Cabal in Washington
Patrick Martin With a series of air strikes beginning Friday and continuing through the weekend, the United States has gone to war again in Iraq. This new imperialist military adventure has been launched in defiance of overwhelming popular opposition and ...Read More »
Ukraine's Conflict: A History and Status-Report, for Ukraine, U.S. and the World
See Barack Obama's Real Achievements in Ukraine, with Your Own Eyes, via Videos: They're Like George W. Bush's Real Achievements in Iraq, But Authentically Nuclear Eric Zuesse RINF Alternative News (This article will consist primarily of videos documenting actual events. ...Read More »
U.S. 'News' Media Propagandize for War Against Russia
Eric Zuesse RINF Alternative News Typical is TIME Magazine, which headlined on 24 July 2014, "In Russia, Crime Without Punishment." The sub-head, from Simon Shuster, "reporting" for the Russia-hating regime of Barack Obama, in the Russia-hating Ukrainian capital Kiev, was the ...Read More »
Violence and Political Upheaval Plunge Iraq Deeper into Chaos
Presidential vote delayed as airstrikes and bombings continue Deirdre Fulton Iraq's Parliament delayed its vote for a new president Wednesday, following an overnight bombing in Baghdad that killed more than 30 people, including many civilians. Islamic State, the al Qaeda offshoot that is ...Read More »
America's Nazi Allies in Israel and Ukraine
Eric Zuesse RINF Alternative News The U.S. is now the chief sponsor of two nazi, ethnically cleansing, nations. In one of them (Ukraine), the U.S. President, Barack Obama, himself placed nazis into control there; the nazi control was imposed by him, ...Read More »
America Is Guilty if Americans Don't Prosecute Obama
Eric Zuesse RINF Alternative News On Sunday, July 13th, Jason Easley — at politicsusa.com, which bills itself "Real Liberal Politics" — bannered, "Top House Republican Admits That There Are No Grounds To Impeach President Obama," and Easley reported that, "The [Republican] chairman ...Read More »