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Disney California Adventure
Hollywood Land
Hollywood Land is a tribute to Hollywood past and present. Classic architecture sets the tone and transports you to Hollywood's Golden Age. From the legendary Hyperion Theater to the Hollywood Tower Hotel, everything old is new again when a generous touch of Disney magic is applied. Entertainment is the focus with spectacular stage shows, a game show, an insider's look at the animation process, and a hotel with a very quirky elevator.
- Turtle Talk with Crush
- Monsters Inc. Mike & Sulley to the Rescue!
- Twilight Zone: Tower of Terror
- Disney Animation
- Jim Henson's Muppet Vision 3D
- Disney Junior Live on Stage!
- Shopping
- Character Greetings
- Hollywood Backlot Dining and Refreshments
Monsters, Inc. Mike & Sulley to the Rescue (Opened January 2006)
This slow moving, dark ride is fun for all ages.
Your taxi ride through Mostropolis is interrupted by breaking news…"A child is loose in Monstropolis!".
Take a ride through the city, where you see various scenes from the movie including Harry Hausen's restaurant and watch as Mike and Sulley try to return Boo to her home. Before exiting the ride you get one last personalized goodbye, from the grouchy Roz.
Twilight Zone: Tower of
(Opened May 2004)
FASTPASS Attraction
This attraction is based on the Twilight
Zone television show. Fans of
the Twilight Zone will delight in the more than
100 references to classic episodes found throughout
the queue. The bellhop
ushers you into the library. As the lights dim,
the TV flickers and your host, Rod Serling appears
on screen. This is when you learn of the ill-fated
day when five passengers vanished from the elevator.
You'll next proceed through the boiler room
to the service elevators. Once you're belted
in, prepare for a trip to the fifth dimension.
There's no mistaking that you entered into
the Twilight Zone.
Restrictions: Height restriction: 40" - Inaccessible to strollers. Wheelchair/ECV accessible. Assistive listening devices available at Guest Relations. If you have difficulty climbing stairs, request the elevator to the right. You should be in good health, free of heart, back, neck problems, motion sickness or other conditions that could be aggravated while riding this attraction. Expectant mothers should not ride.
Disney Animation (Opened February 2001)
Click Here for Photos The Disney Animation attraction offers a fascinating insight into the world of animation with several exhibits to visit, each offering a unique experience:
The Animation Courtyard: The lobby of the Animation building features large screens with clips and music from your favorite Disney animated features.
Animation Academy : Join a Disney artist and learn the secrets of how to draw a classic Disney character.
Sorcerer's Workshop : For hands-on fun, this is the place to go. As you enter, you can try your hand at creating your own animation. Next you'll enter the Beast's Library. Prominently displayed on a shelf is the glass-encased Enchanted Rose. As the petals fall, wait and watch the sequence of events that follow. In the library, you can take a personality test, conducted by Lumiere and Cogsworth, to see which character you resemble. You may discover that there's a bit of a Disney villain lurking within. In Ursula's Grotto, you can voice a scene from the Little Mermaid, and then listen as it's played back with you doing the vocals.
Character Close-Up: In the Character Close Up area, you'll find the Toy Story Zoetrope. This large carousel-like disc, features three-dimensional versions of your favorite Toy Story characters and creates the illusion of movement (animation) by spinning and using strobe lights.
Turtle Talk with Crush: This interactive show with everybody's favorite turtle from Finding Nemo, who appears on the screen to look at all "the humans in the human tank". Through some amazing technology, Crush is able to interact with the children in the audience.
Jim Henson's Muppet
Vision 3D (opened February 2001)
The Muppets, led by Kermit and Miss Piggy, embark on a madcap 3-D adventure in this delightful attraction. Sight gags abound in the queue area and the pre-show. The theater itself is a copy of the Muppet Show stage. As the penguin orchestra tunes up, you don your 3-D glasses and watch the mayhem unfold. In addition to Muppet favorites, Waldo the "spirit of 3-D" leads the cast in an unforgettable romp. There's a live character, animatronics and all sorts of visual effects incorporated in this hilarious presentation. Including the pre-show, you can expect it to last 25 minutes.
Restrictions: Accessible to strollers, Wheelchair/ECVs. Assistive listening devices available at Guest Relations. Closed captioning and reflective captioning.
DIS Unplugged: Disneyland Edition Podcast
Disney Junior
Disney Junior features current Disney Channel favorites in a cute 20 minute interactive show.
Characters from "Jake and the NeverLand Pirates", "Sofia the First", "Mickey Mouse Clubhouse" and "Doc McStuffins" are among those featured in this preschool designed show.
The audience is invited to sit on the floor. Kids can join in and sing and dance along with familiar tunes from the Disney Channel pre-school lineup.
- Gone Hollywood – located opposite Disney Junior-Live on Stage, this Art Deco themed shop features trendy and glitzy gifts, stylish apparel, and Hollywood themed souvenirs.
- Tower Hotel Gifts - Tower of Terror merchandise
- Off the Page – located adjacent to Disney Animation (you can exit the attraction via this shop.) Features Disney collectibles, animation cels, limited edition prints, books, tapes, DVDs, and other souvenirs. The fun décor is worth a visit. On the ceiling are sketches with the characters literally falling "off the page."
- Studio Store – In zany Muppet fashion, check out the tongue-in-cheek props found throughout this shop. This shop features Muppet themed clothes, toys and souvenirs.
Meet Sofia the First, Doc McSuffins and more of your favorite Disney Junior stars in Hollywood Land. Check daily schedule for times.
- Blog - "Grand New" Gingerbread House at Disneyland's Grand Californian Hotel and Spa
- Top 5 Dining Experiences at the Disneyland Resort - Here are what I feel (at this particular moment) are the top dining experiences at the Disneyland Resort.
- Blog - Disneyland Area Hotel Review - SpringHill Suites
- Blog - Christmas at Cars Land in Disney's California Adventure
- Save up to 30% on a stay at Aulani - Discount is available most nights 4/6 - 6/15/15.
- Mad T Party at California Adventure ends November 30th - Mad T Party will have its final performance on 11/30/14. No word yet on what will replace it.
- Top 5(+) things that are better at Walt Disney World than at Disneyland - Bigger may not always be better, but isn't always worse either. I can't resist countering with an article that lists, in my view, the things that are better at Walt Disney World.
- Blog - Disneyland Area Hotel Review - Hyatt Place
- Blog - Jingle Cruise: a Better and Funnier Voyage in 2014
- Blog - Disney's Second Try at World of Color: Winter Dreams feels more Disney
- Blog - The Wreaths of Disneyland's Small World Holiday
- Top 5 things that are better at Disneyland than at Walt Disney World - Bigger isn't always better and while Walt Disney's original theme park is smaller, it still has the advantage over its East-coast counterpart in a few key areas.
- My favorite bathrooms in California Adventure - Being a newer park, the facilities are better thought out and larger. Still, you do have options..... Let's take a look at the bathrooms of DCA.
- Blog - Disneyland Weekly Update - 11/10/14
- Free breakfast offer for length of stay at Aulani - This offer must be booked by December 18.
- Blog - Frozen Ice Palace Debuts at Malls Across the Country
- VIDEO: Disney Park Bench - Sleeping Beauty Castle Courtyard - Sleeping Beauty Castle - Take 5 Minutes to Relax at Sleeping Beauty Castle Courtyard - Sleeping Beauty Castle
- Aulani plans Thanksgiving feast - Celebrate the holiday in the Kaiona Ballroom. The menu will include traditional Thanksgiving favorites with an island twist.
- VIDEO: Disney Park Bench - Disneyland Park Hub - "Partners" Statue - Take 5 Minutes to Relax at Disneyland Park Hub - "Partners" Statue
- VIDEO: Disney Park Bench - Haunted Mansion Queue - Haunted Mansion Holiday - Take 5 Minutes to Relax at Haunted Mansion Queue - Haunted Mansion Holiday
- Blog - Disneyland Weekly Update - 11/03/14
- VIDEO: Disney Park Bench - Fantasy Faire Path - Sleeping Beauty Castle - Take 5 Minutes to Relax at Fantasy Faire Path - Sleeping Beauty Castle
- VIDEO: Disney Park Bench - Sleeping Beauty Castle Bridge - Sleeping Beauty Castle - Take 5 Minutes to Relax at Sleeping Beauty Castle Bridge - Sleeping Beauty Castle
- VIDEO: Conjure A Villain at Disneyland Park - During Halloween Time at Disneyland Park, you can conjure a villain to meet back in the Halloween Carnival in Big Thunder Ranch. You never know what villain you are going to get!
- VIDEO: Mickey's Costume Party Cavalcade 2014 - Mickey's Costume Party Cavalcade is the special parade that takes place during Mickey's Halloween Party at Disneyland Park.
- VIDEO: Cadaver Dans sing "Headless Horseman" on the Rivers of America - During Mickey's Halloween Party at Disneyland Park, the Dapper Dans transform into the Cadaver Dans and move their act from Main Street USA to the Rivers of America to perform some Halloween-themed numbers including this version of "Headless Horseman" from "The Legend of Sleepy Hollow" animated Disney film.
- VIDEO: Disney Park Bench - New Orleans Square - Rivers of America - Take 5 Minutes to Relax at New Orleans Square - Rivers of America
- Blog - Mickey's Halloween Party vs. Mickey's Not-So-Scary Halloween Party
- My favorite bathrooms in Disneyland Park - What makes a good bathroom? Is it clean? Is it busy? How big is it? How crowded is it?
- VIDEO: 2014 Mickey's Halloween Party Overview - Mickey's Halloween Party is the yearly event that brings the spookiest holiday of them all to Disneyland Park.
- Planning a Disney Halloween Party in 10 Steps - A few ideas and 10 steps for planning a Disney Halloween party in your own neighborhood.
- New Anaheim transportation hub to open next month
A new Anaheim transportation hub is scheduled to open in early December.
- Last surviving child of Knott's founder dies
Marion Knott, youngest daughter of Knott's Berry Farm founders Walter and Cordelia Knott, passed away recently at age 92.
- Knott's Berry Farm announces new 4-D attraction
Knott's Berry Farm has announced Voyage of the Iron Reef, a new interactive ride set to open Spring 2015.
- Superheroes take over the inaugural Avengers half marathon
Runners dressed in costume for the inaugural running of the Avengers Superheroes Half Marathon this weekend in Anaheim.
- Schedule for handmade candy canes at Disneyland
Candy cane-making season begins November 28.


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Many lesbian, gay, bisexual and transgender (LGBT) middle and high school students in Illinois face hostile school environments and lack access to important educational resources, according to state-level data from the Gay, Lesbian & Straight Education Network's (GLSEN) "2013 National School Climate Survey."
The survey, taken in 2013 and released this October, included 7,989 LGBT students, including 279 from Illinois.
The 2013 snapshot for Illinois shows most LGBT students surveyed in the state have faced some form of victimization at school, with 7 in 10 students saying they have been verbally harassed based on their sexual orientation in the past year. Another 56 percent of Illinois respondents said they have faced verbal harassment at school due to their gender expression.
Nearly 292,000 tons of coal are burned each year to power Walmart's facilities in Illinois, producing 539,000 metric tons of greenhouse gas emissions annually, shows a new report examining the carbon footprint of the nation's largest retailer.
Out of all U.S. states and the District of Columbia, Walmart's coal consumption is the second highest in Illinois behind Texas, according to the Institute for Local Self-Reliance's (ILSR) report titled, "Walmart's Dirty Energy Secret: How the Company's Slick Greenwashing Hides Its Massive Coal Consumption."
Walmart is one of the country's biggest users of coal-fired electricity overall, with its U.S. stores and distribution centers collectively responsible for the annual consumption of 4.2 million tons of coal, resulting in almost 8 million metric tons of carbon pollution each year, the report found.
"If you put all of that coal into rail cars, you'd have a train 43,000 rail cars long that stretched for over 420 miles," report co-author Stacy Mitchell, a senior researcher at ILSR, said on a conference call with reporters.
Former workers of a dry cleaners in Chicago's South Loop filed a federal lawsuit against the company Monday morning, alleging that they were asked to complete more work than was possible, forced to work overtime without proper compensation and experienced unfair retaliation when they complained.
"These are pretty straightforward violations of the law. You have to pay your workers for every hour they work," said Sean Morales-Doyle, the lawyer representing the three former workers.
Hortensia Castaneda, Naivi Cobos and Ana Rodriguez filed the lawsuit Monday in U.S. District Court claiming CD One Price Cleaners unlawfully retaliated against its workers and violated the Fair Labor Standards Act (FLSA), the Illinois Minimum Wage Law and the Illinois Wage Payment and Collection Act.
The three women worked at the CD One Price Cleaners, at 2200 S. Michigan Ave. Their lawsuit alleges that they were required to do more work than was feasible during their shifts, such as ironing 200 garments per hour, and were also responsible for making hangers for those garments at the same time.
Immigration reform supporters gathered for a viewing party of President Barack Obama's executive order speech on Friday in Chicago's Pilsen neighborhood.
"We're not a nation that kicks out strivers and dreamers who want to earn their piece of the American dream," Obama said during his speech at Del Sol High School in Las Vegas. "We didn't raise the Statute of Liberty with her back to the world, we did it with her light shining."
U.S. Sen. Dick Durbin (D-IL), a staunch proponent of immigration reform and one of about two dozen attendees at the Casa Michoacan viewing party, said "history is being made."
Low-wage school custodians from Elgin, Wheaton, Rockford and other areas picketed outside of the Illinois Association of School Boards conference in Chicago Friday morning, demanding paid holiday and sick days.
Chanting "Hey, District U46. Your low wages make us sick," the custodians, hired by school district contractors and represented by SEIU* Local 1, also called for better pay and health benefits.
"We want to show (school board officials) that we're not happy with what they pay to our custodians," Carolina Villalobos, an SEIU Local 1 organizer, said outside of the Hyatt Regency Chicago, where the conference was held.
Sign up to receive the PI extra. This daily email digest includes highlights from our original content, updates on the day's breaking political news, and links to the best of the web.

subset: commoncrawl


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What: Youth 2000 National Christmas Retreat
When: 12th - 14th December 2014
Where: Newbridge College,
Co. Kildare
Contact: (01) 6753690
or email:
Theme: "The Spirit of the Lord God is upon me" Is 61:1
Starts at 8pm Friday night, 9.30am on Saturday & Sunday morning
Online Bookings
Welcome to our FREE BUSES page for the Youth 2000 Christmas Retreat at Newbridge, Co. Kildare from 12th to 14th December 2014.
For more information on the various buses and timetables of different routes from all around Ireland, please visit the page! (Book now while there is still space!)
"Blessed are the merciful: they shall have mercy shown them" (cf. Mt. 5:7)


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World Bulletin / News Desk
Protests spread after broadcasting of anti-Islam video insulting the Prophet Mohammad (peace be upon him). The biggest protest occured in Egypt. Thousands of Muslims organized protests such as in Yemen, Palestine, Qatar, Banghladesh, Indonesia, Kashmir, Libya. There will be a protest in Turkey, on Friday night in Taksim square.
Demonstrators furious at a film they say insults the Prophet Mohammad clashed with police near the U.S. embassy in Cairo on Friday before a nationwide protest called by the Muslim Brotherhood which propelled Egypt's Islamist president to power.
Police used water cannons and fired warning shots into the air to disburse hundreds of protesters who rallied for a second day at the U.S. Embassy in Yemen's capital against a film seen as insulting to Islam, in today protests.
The crowds demontrate anti-Islam film in Indonesia and Banghladesh. They were almost 10 thousands people in Banghladesh. Protestors gathered in front of U.S.A. embassy. Almost 200 Indonesians showed their anger over an anti-Islam film Friday by chanting "death to Jews!" and "death to America!" in a largely peaceful protest outside the heavily guarded U.S. Embassy, reportedly.
There were a big crowd in the capital of Qatar.
PALESTINE and GAZA
Israeli authorities are deploying more forces in Jerusalem's Old City on Friday after a film about the Prophet Muhammad triggered anti-American protests across the Muslim world.
300 Turkologists have come together in honour of the Kabardino-Balkaria people in Moscow.
Bestikas Football club star, Senegalese Demba Ba's twitter remarks with one of his followers attracted attention.
The Islamic Center got its start a half-century ago when seven immigrant families living near the Fore River Shipyard joined to build the mosque at 470 South St
All ID cards and passport photos in Belarus that show women with a headscarf are banned
Some of the most respected Muslim charities and organizations included on list of groups suspected of having 'terrorist' links
"The First Latin American Muslim Leaders Religious Summit" hosts 76 religious leaders from more than 40 countries
The Washington National Cathedral opens its gates to Muslims for the first time to perform Friday prayer
Tell Mama says recent events in the UK and internationally have resulted in a sharp increase in anti-Muslim hate crimes
Imam Salim Mwarangi was shot dead in Likoni, a suburb outside off the Mombasa Island, in the latest attacks targeting Muslim clerics in the coastal city.
In 1970, only two mosques existed in the country, but now more than 200 offer sanctuary to Japan's Muslims.
Bigoted actor sustains bloodied nose while testing Canadians' attitudes toward Muslims, but the prime minister has not publicly uttered one word of support for Canadian Muslims following the hate attacks
The National Council of Canadian Muslims said it has seen a tenfold increase in reports of harassment, including racial slurs on public buses, notes left on car windshields and bullying at schools.
CAIR says it has received reports from around the nation of mosque officials being asked to meet with FBI agents and then being pressed to inform on members of their congregations.
Belgium's Muslim women speak out against social exclusion for practicing their religion.
The mosque was hit overnight with red spraypainted graffiti reading "Go home" and its windows were smashed
Russian Muslims want to be formed a comission agains the ban on the Islamic books including some Hadith works


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Chinese artist Dai Xiang's modern reinterpretation of the famous Chinese painting "Along the River During the Qingming Festival" epitomized modern China.
Chinese netizens react to a list of funny and strange Chinese names on National ID cards, airplane boarding passes, name tags, and signs.
An Anhui security guard dies moments after a female Chinese government cadre insults him as "a mere watchdog" for refusing to let her drive against traffic.
Laoganma founder Tao Huabi, regarded as an icon among Chinese for her tasty product and honest business, was recently awarded A8888 license plate by the government.
Chinese netizens react to packed warehouses across the country as shipments were prepared for Single's Day, China's largest online shopping event.
A student caught playing with his mobile phone quickly uses it to take a series of photos of the angry teacher as she comes towards him to confiscate it.
A school in China recently installed the teacher's office next to the classrooms in an effort to monitor students, netizens compare this to being in a prison.
Chinese netizens respond in shock to a recent incident where villagers tied up and set fire to forced demolition crew members after 2 villagers were killed.
China's infamous "chengguan" city management department personnel are caught on video this time apparently beating up a couple that owns a Jiangxi flower shop.
Chinese netizens scoff at a Shandong "red tourism" attraction based on a famous Communist propaganda movie set during China's War of Resistance Against Japan.
Translated Chinese netizen reactions to a viral video of an American angrily confronting an elderly woman panhandler in Oklahoma caught driving a brand new car.
Chinese netizen reactions to a story where a Guangxi court has ruled that a cargo driver must pay 1.05 million RMB in compensation after hitting a Rolls-Royce.
Chinese netizens respond negatively to state-broadcaster CCTV using an overworked sanitation worker's death to promote an anti-littering message to the public.
Cynical Chinese netizens react negatively to a 27-year-old Tsinghua University graduate being appointed Deputy Mayor of Longhai city in Fujian province.
An elderly Chinese man stood in front of a Hebei Baoding public bus preventing it from leaving because other passengers did not give up their seats for him.
A Chinese girl calls on young people to change PRC society for the better by refusing to become the adults they themselves despise, on a TV speech competition.
Chinese netizens disgusted by an Anhui Xinhua University president riding around in a black convertible Audi like a government leader to inspect new students.


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Vegetable Scramble
Students get moving while learning about a variety of vegetablesTags: nutrition activities, middle school, dinner
The drawing and registration for the 2015 United Airlines NYC Half is now open! Runners with guaranteed entry must claim their entry before Dec 3, 2014.
Together, students create an alphabet of their favorite, healthy dinner foods in this active game
Tags: nutrition activities, middle school, dinner
|Students pass a ball while creating an alphabet of healthy dinner foods.
|Students will identify some healthy dinner foods.
|One basketball or medium-sized bouncy ball
Activity Note
Certain letters, such as X, are difficult, so they can be skipped or you can provide hints.
Healthy ("Energy"/"Go") Dinner Foods:
Possible Names:
Possible Places:
Further information about the national standards can be found here.


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Sigmar Polke was one of the most experimental artists of the twentieth century, he worked in wide range media during his 50 year career.
This Tate Modern retrospective is one of the first to bring together his work on painting, drawing, photography, film and sculpture, notebooks, slide projections and photocopies. 939 more words


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During the recent Israeli election, a group of Israeli activists called attention to Palestinian statelessness by offering their votes to Palestinians living in the occupied territories.
Mel Frykberg, last updated: February 04, 2013
Inter Press Service
Unknown to the Israeli government or the Israeli electorate, hundreds of Palestinians from the West Bank and Gaza took part in the recent Israeli elections by default thanks to an act of civil disobedience by Israeli peace activists.
Real Democracy, an initiative comprising thousands of Palestinians from the occupied Palestinian Territories and Israelis, decided that the undemocratic nature of Israel and its illegal occupation of Palestinian territory needed to be challenged.
One month prior to the elections the Real Democracy rebellion started on a Palestinian-Israeli Facebook page. Thousands of Palestinians and Israelis joined the initiative.
More than a thousand Israelis decided to give up their votes to Palestinians from the occupied territories in an act of protest against what the participants saw as the undemocratic nature of the Israeli elections and the United Nations system. Shimri Zamaret, 27, an Israeli researcher from Warwick University in the UK, was one of the founders of the Real Democracy movement.
"The idea started in the UK when people there decided to give up their votes to people in Afghanistan, Bangladesh and Ghana to protest the stranglehold of Western powers in the UN over less powerful countries," Zamaret told IPS.
"We decided to start a similar movement in Israel and Palestine. Palestinians live under a double apartheid system. The Israeli Parliament and the UN are based on inequality between citizens – and are therefore undemocratic. The UN Security Council is dominated by the five superpowers which won World War Two and is totally unrepresentative of the international community today," Zamaret told IPS.
"Israeli citizens elect a government that controls Palestinians, but Palestinians cannot vote and do not have an independent state," said Zamaret who was jailed for two years as a conscientious objector for refusing to serve in the Israel Defence Forces (IDF).
"Through the Israeli government (and the undemocratic Security Council), Israelis also have a de facto veto power over the UN Security Council system. Citizens do not have a direct voice in the United Nations, and the Palestinian government's UN membership got vetoed," said Zamaret.
"Palestinians therefore do not have any vote in the UN nor any control over their country. So undemocratic Israel's monopoly of force is supported by undemocratic control over international institutions."
Zamaret gave his vote to Omar Abu Rayan, a 19-year-old student from Hebron who ironically decided the best move was not to use the vote but to 'boycott' the Israeli elections altogether despite a long debate with Israelis over using 'his' vote to make a difference.
"I appreciate the move by the Israeli activists to give voteless Palestinians a voice in the Israeli elections but I don't think this would have made any difference, it wouldn't have changed anything on the street. The peace parties in Israel are too small and don't have enough influence. The no vote was a protest vote," Abu Rayan told IPS.
"We aren't expecting the Real Democracy initiative to make a big difference. It's a symbolic gesture and only relevant as part of a larger campaign to de-legitimise Israel on an international level," said Israeli freelance translator Ofer Neiman, who also gave up his vote.
"What we wanted to do was make a noise about the occupation and the treatment of Palestinians. We have discrimination even within Israel against Palestinians with Israeli citizenship. Real Democracy is part of a broader international movement, specifically the Boycott, Disinvestment and Sanctions (BDS) campaign against Israel.
"Most of the Israeli activists are involved in other activist movements and we all believe that only international pressure on Israel through sanctions will help bring about the end of the occupation," Neiman, who was kicked out of the IDF for his left-wing political views and was monitored as a student at university for activism against the occupation, told IPS.
Neiman gave his vote to Bassam Aramin from the West Bank village of Anata. "I am a Palestinian citizen, I live in East Jerusalem. I am 44," said Aramin.
"I am a bereaved father – my 10 year-old daughter Abir was killed by an Israeli soldier on the 16th Jan, 2007, but I have no control over the Israeli government who sent the soldier there. I live under occupation. We Palestinians have no vote or veto in the UN Security Council or the government that controls us. That's undemocratic."
Aramin asked Neiman to use his vote for the left-wing Israeli party Hadash even though he is not a supporter of the party.
Palestinian activist Musa Abu Maria, from Beit Omar in the southern West Bank, is also a member of Real Democracy. He used the vote he was given to vote for leftist Haneen Zoabi, one of the few Palestinian members of the Israeli Knesset or parliament.
"Many of the Palestinians who took part in the initiative wanted to support the efforts of our Israeli colleagues," Abu Maria told IPS.
Mel Frykberg is a contributor to Inter Press Service.
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The Foundation for Defense of Democracies (FDD), a neoconservative think tank and advocacy group based in Washington, has endeavored to undermine the Obama administration's negotiations with Iran. FDD executive director Mark Dubowitz recently voiced support for measures by hawkish members of Congress that seek to give Congress a greater role in the negotiations, such as getting an "up or down vote on" any deal. Dubowitz has also suggested that Congress "defend the sanctions architecture" on Iran even if an agreement is reached.
The Center for Security Policy (CSP), run by notorious Islamophobe Frank Gaffney, has rabidly opposed negotiating with Iran over its country's nuclear program. With the deadline to reach an agreement fast approaching, CSP fellows have argued that it would pose "an existential threat to Israel" and a "deadly threat to U.S. national security." They have also urged Congress to "repudiate the nuclear talks and any agreement resulting from them."
AIPAC, "America's pro-Israel lobby," has attempted to influence the nuclear negotiations between Iran and the P5+1 by supporting hawkish congressional measures that many analysts say could derail the diplomatic process. The lobby has strongly endorsed a letter from Reps. Ed Royce (R-CA) and Eliot Engel (D-NY) pressuring Secretary of State John Kerry to broaden the scope of demands in a potential agreement, which many observers have criticized as containing "distortions of the truth."
Although largely dormant in recent years, the Committee on the Present Danger—the Cold War-era pressure group that was re-launched after 9/11 with support from leading neoconservatives—continues to use it website to plug fear-mongering media stories and op-eds, focusing mainly on Iran. One recent article, written by a CPD member, rails against efforts to reach a diplomatic compromise over Iran's nuclear program, claiming: "It is hard to rationalize the past history of this fanatical Muslim regime's secret nuclear efforts and any hope that it would abide by such an agreement, or, indeed, that UN or other surveillance would be more effective than in the past."
The Foreign Policy Initiative (FPI), a leading neoconservative think tank, sought to frame the 2014 midterm elections as a "foreign policy election," even though only 13 percent of voters listed foreign policy as a top issue in exit polls. FPI nevertheless hopes that the Republican-controlled Senate will "actively lead on foreign policy issues" and has prioritized passing Sen. Robert Menendez's controversial Nuclear Weapons Free Iran Act. The bill would impose additional sanctions on Iran and would likely scuttle on-going negotiations with Iran.
For media inquiries,
or call 202-234-9382.
November 24, 2014
Negotiators in Vienna failed to reach an agreement over Iran's nuclear program and extended the deadline to July 1, 2015.
November 19, 2014
The Bipartisan Policy Center, which claims to support "reasoned negotiation and respectful dialogue," has firmly aligned itself with neoconservatives on Iran.
November 18, 2014
Israel's chief fear in a possible nuclear deal with Iran is that it will lose an enemy that it shares in common with the United States, and thus Washington's commitment to its security.
November 17, 2014
A Republican-controlled Senate could leave a huge imprint on President Obama's foreign policy agenda during his last two years in office.
November 11, 2014
George W. Bush and Barack Obama both sought to convince former Iraqi Prime Minister Nouri al-Maliki's to keep U.S. troops being in Iraq. Both failed.
November 08, 2014
As the November 24 deadline for reaching a comprehensive nuclear deal with Iran approaches, the different sides are scrambling to ensure all bases are covered before the official resumption of talks in Vienna on November 18.
November 06, 2014
Once a taboo topic in Washington, leading members of the foreign policy establishment now increasingly scrutinize Israel's actions.


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Chris Powell's Tools for Staying on Track
These 10 tips from the Extreme Makeover: Weight Loss Edition's trainer will keep you on track in 2013.
Support Group
Success comes more easily when you're surrounded by people who support you. Find friends and family who will help you reach your goals, and pay it forward, as well. If you see someone at the gym who looks like they could use some support or friendship, be bold and reach out to them. You'll both benefit.
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Please help me plan for a trip to Sacramento
- Disneyfreak May 22, 2014 12:27 PM
I'm coming to Sacramento mid July for business. I will be staying at the Hyatt near the convention center on J Street. I won't have a car, but am not adverse to taking public transportation. I have 4 dinners to plan and one morning/afternoon to explore.
My spending can't be extravagant -- about $50 for dinner with tax and tip. I like all sorts of food. Where would you send me?
Also, any thoughts on fun foodie things to do my free day. I love to explore ethnic neighborhoods and foodie spots.
Thanks so much!
PS -- I know there are other threads on Sacramento (like the one on things to eat before you die) but I also know that the food scene in an area changes all the time so I'm seeking recent recommendations.
It's been a few years since I regularly went to Sacramento for business, but I would definitely return to the Waterboy restaurant which is near Capitol Ave and 20th.
Your hotel is really centrally located, so if you head east on J street you will end up in the Midtown neighborhood, not ethnic, but urban, with lots of shops and small restaurants to check out. Downtown Sacramento is very walkable, but the temperatures in July are likely to be hot. It does get cooler once the sun starts to go down, so you might plan on a later dinner.
Earlier this year I had two days of meetings near the Convention Center. While I had a car, the places I explored were within a mile of your hotel.
The highlight for me was taking a look around what remains of what used to be a Japanese-American neighborhood. These businesses are within two blocks of each other.
June's Cafe
Taiwan Best Mart
Wakano Ura
Other stops:
Hot Italian
Anatolian Table Turkish Bistro
Devine Gelateria
Coffee Works & Jumpstart Cafe
Have only had catered lunch from here and haven't visited in person, but wanted to mention that Magpie Cafe is within the one-mile radius too.
re: Melanie Wong
Note that Wakano Ura closed a few years ago. It has been sadly missed I am sure.
re: Melanie Wong
Thanks for this information. I'm liking some of those choices.
Burgers and Brew on R st
Temple Coffee at least once, they have a location a couple blocks from where you are staying
Having spent many a trip doing exactly the same thing I know what you are up against.
I liked the Frank Fat traditional chinese wedding dinner items, which is a few blocks down the street from the Hyatt towards the river - this is the old famous political watering hole - their walnut shrimp alone are worth the trip. And top it with their famous and out of character banana cream pie.
Then must later I also learned about the collection of small restaurants heading away from the river up about 5-6 blocks in a historic little cluster on J Street I believe - lots of choices. But most of the places right around the Hyatt and Convention Center were pretty routine.
We like Ella's. I think it might be nearby.
In addition to Magpie,there are some recent updates to the "before you die" thread.
There are quite a few options in your vicinity:
Ella is a bit on the pricey side but worth it and I think you could stay under $50.
Mother is a new restaurant making outstanding food at great prices that just happens to be vegeterian. I know for dinner they have a 10 course menu for two that is $40. Probably the best place in Sacramento right now.
Dad's Burgers is on J for a quick filling lunch.
Some other places I like: the grange, buds, Estelle's, pizza rock (terrible name/decor but really good pizza), zocalo, mayahuel.
Let me add that I really like Waterboy. Their food and service have always been a step ahead.
2000 Capitol Ave. / very centrally located
re: Tripeler
+1 always a must stop for us, also if you're into sweetbreads this is the place, Lady PB is not, but still is always up for a sidewalk seat and their great food.
re: PolarBear
Sweetbreads... I think they're offal, but I have always had something I really loved at Waterboy. I don't remember sidewalk seats, but that could be new.


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Welcome to Arab and Muslim American Studies
Today, an estimated 3.5 million Arabs and Arab Americans live in the United States. Arab Americans in Michigan constitute one of the largest Arab American populations in the U.S. Figures on the number of Muslims in the United States range widely from 3 to 12 million, many of whom are African American, South Asian American, and Arab American. The population of Muslims in the U.S. is diverse and includes a growing Latina/o Muslim population. In addition, the Arab region, its diasporas, Muslim Americans, and recent Muslim immigrants have become increasingly central to U.S. history and politics. Immigration and displacement by war and the forces of global economy are among the factors that have sparked movements of Arab and Muslim people to the United States.
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These large-footprint premium sedans have very outspoken fan clubs, for at this scale a company's design logic is laid out big on the table for all to dissect. Speaking for myself, I am an Audi A8/Volkswagen Phaeton kind of person. I absolutely enjoy the new Mercedes-Benz S-Class and have a certain weakness for the BMW 7 Series, but it's the A8 in this class that yanks me by the ear lobe. The large Japanese models, Jaguar XJ and Hyundai Equus are great work, and the newer Cadillac XTS is good stuff, but I'll still take my A8. The 2015 model is a mid-life updo for the A8 (and S8), and it... Read More


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Publications (123)429.98 Total impact
Article: A Mutation Causing Brugada Syndrome Identifies a Mechanism for Altered Autonomic and Oxidant Regulation of Cardiac Sodium Currents.[Show abstract] [Hide abstract]
ABSTRACT: -The mechanisms of the electrocardiographic changes and arrhythmias in Brugada syndrome (BrS) remain controversial. Mutations in the sodium channel gene, SCN5A and regulatory proteins that reduce or eliminate sodium current (INa) have been linked to BrS. We studied the properties of a BS-associated SCN5A mutation in a protein kinase A (PKA) consensus phosphorylation site, R526H. -In-vitro PKA phosphorylation was detected in the I-II linker peptide of wild type (WT) channels but not R526H or S528A (phosphorylation site) mutants. Cell surface expression of R526H and S528A channels were reduced compared with WT. Whole-cell INa through all channel variants revealed no significant differences in the steady-state activation, inactivation and recovery from inactivation. Peak current densities of the mutants were significantly reduced compared to WT. Infection of 2D cultures of neonatal rat ventricular myocytes with WT and mutant channels increased conduction velocity (CV) compared with non-infected cells. PKA stimulation significantly increased peak INa and CV of WT but not mutant channels. Oxidant stress inhibits cardiac Na currents; WT and mutant INa decreases with the intracellular application of NADH, an effect that is reversed by PKA stimulation in WT but not in R526H or S528A channels. -We identified a family with BrS and an SCN5A mutation in a PKA consensus phosphorylation site. The BrS mutation R526H is associated with a reduction in the basal level of INa and a failure of PKA stimulation to augment the current which may contribute to the predisposition to arrhythmias in patients with BrS, independent of the precipitants.Circulation Cardiovascular Genetics 05/2014; · 6.73 Impact Factor
Article: Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin.[Show abstract] [Hide abstract]
ABSTRACT: The electrophysiological consequences of cardiomyocyte and myofibroblast interactions remain unclear, and the contribution of mechanical coupling between these two cell types is still poorly understood. In this study, we examined the time course and mechanisms by which addition of myofibroblasts activated by transforming growth factor-beta (TGF-β) influence the conduction velocity (CV) of neonatal rat ventricular cell monolayers. We observed that myofibroblasts affected CV within 30 minutes of contact and that these effects were temporally correlated with membrane deformation of cardiomyocytes by the myofibroblasts. Expression of dominant negative RhoA in the myofibroblasts impaired both myofibroblast contraction and myofibroblast-induced slowing of cardiac conduction, whereas overexpression of constitutive RhoA had little effect. To determine the importance of mechanical coupling between these cell types, we examined the expression of the two primary cadherins in the heart (N- and OB-cadherin) at cell-cell contacts formed between myofibroblasts and cardiomyocytes. Although OB-cadherin was frequently found at myofibroblast-myofibroblast contacts, very little expression was observed at myofibroblast-cardiomyocyte contacts. The myofibroblast-induced slowing of cardiac conduction was not prevented by silencing of OB-cadherin in the myofibroblasts, and could be reversed by inhibitors of mechanosensitive channels (gadolinium or streptomycin) and cellular contraction (blebbistatin). In contrast, N-cadherin expression was commonly observed at myofibroblast-cardiomyocyte contacts, and silencing of N-cadherin in myofibroblasts prevented the myofibroblast-dependent slowing of cardiac conduction. We propose that myofibroblasts can impair the electrophysiological function of cardiac tissue through the application of contractile force to the cardiomyocyte membrane via N-cadherin junctions.Journal of Molecular and Cellular Cardiology 01/2014; · 5.15 Impact Factor
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ABSTRACT: Light-mediated silencing and stimulation of cardiac excitability, an important complement to electrical stimulation, promises important discoveries and therapies. To date, cardiac optogenetics has been studied with patch-clamp, multielectrode arrays, video microscopy, and an all-optical system measuring calcium transients. The future lies in achieving simultaneous optical acquisition of excitability signals and optogenetic control, both with high spatio-temporal resolution. Here, we make progress by combining optical mapping of action potentials with concurrent activation of channelrhodopsin-2 (ChR2) or halorhodopsin (eNpHR3.0), via an all-optical system applied to monolayers of neonatal rat ventricular myocytes (NRVM). Additionally, we explore the capability of ChR2 and eNpHR3.0 to shape action-potential waveforms, potentially aiding the study of short/long QT syndromes that result from abnormal changes in action potential duration (APD). These results show the promise of an all-optical system to acquire action potentials with precise temporal optogenetics control, achieving a long-sought flexibility beyond the means of conventional electrical stimulation.Scientific reports. 01/2014; 4:6125.
Article: Automated Grouping of Action Potentials of Human Embryonic Stem Cell-Derived Cardiomyocytes[Show abstract] [Hide abstract]
ABSTRACT: Methods for obtaining cardiomyocytes from human embryonic stem cells (hESCs) are improving at a significant rate. However, the characterization of these cardiomyocytes (CMs) is evolving at a relatively slower rate. In particular, there is still uncertainty in classifying the phenotype (ventricular-like, atrial-like, nodal-like, etc.) of an hESC-derived cardiomyocyte (hESC-CM). While previous studies identified the phenotype of a CM based on electrophysiological features of its action potential, the criteria for classification were typically subjective and differed across studies. In this paper, we use techniques from signal processing and machine learning to develop an automated approach to discriminate the electrophysiological differences between hESC-CMs. Specifically, we propose a spectral grouping-based algorithm to separate a population of CMs into distinct groups based on the similarity of their action potential shapes. We applied this method to a dataset of optical maps of cardiac cell clusters dissected from human embryoid bodies. While some of the nine cell clusters in the dataset are presented with just one phenotype, the majority of the cell clusters are presented with multiple phenotypes. The proposed algorithm is generally applicable to other action potential datasets and could prove useful in investigating the purification of specific types of CMs from an electrophysiological perspective.IEEE Transactions on Biomedical Engineering 01/2014; 61(9):2389-2395. · 2.35 Impact Factor
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ABSTRACT: Cultured heart cells have long been valuable for characterizing biological mechanism and disease pathogenesis. However, these preparations have limitations, relating to immaturity in key properties like excitation-contraction coupling and β-adrenergic stimulation. Progressive attenuation of the latter is intimately related to pathogenesis and therapy in heart failure. Highly valuable would be a long-term culture system that emulates the structural and functional changes that accompany disease and development, while concurrently permitting ready access to underlying molecular events. Accordingly, we here produce functional monolayers of adult guinea-pig ventricular myocytes (aGPVMs) that can be maintained in long-term culture for several weeks. At baseline, these monolayers exhibit considerable myofibrillar organization and a significant contribution of sarcoplasmic reticular (SR) Ca(2+) release to global Ca(2+) transients. In terms of electrical signaling, these monolayers support propagated electrical activity and manifest monophasic restitution of action-potential duration and conduction velocity. Intriguingly, β-adrenergic stimulation increases chronotropy but not inotropy, indicating selective maintenance of β-adrenergic signaling. It is interesting that this overall phenotypic profile is not fixed, but can be readily enhanced by chronic electrical stimulation of cultures. This simple environmental cue significantly enhances myofibrillar organization as well as β-adrenergic sensitivity. In particular, the chronotropic response increased, and an inotropic effect now emerges, mimicking a reversal of the progression seen in heart failure. Thus, these aGPVM monolayer cultures offer a valuable platform for clarifying long elusive features of β-adrenergic signaling and its plasticity.Journal of Molecular and Cellular Cardiology 09/2013; · 5.15 Impact Factor
Article: Mechanical Coupling of Smooth Muscle Cells Using Microengineered Substrates and Local Stimulation[Show abstract] [Hide abstract]
ABSTRACT: Mechanical stresses directly affect many cellular processes, including signal transduction, growth, differentiation, and survival. Cells can themselves generate such stresses by activating myosin to contract the actin cytoskeleton, which in turn can regulate both cell-substrate and cell-cell interactions. We are studying mechanical forces at cell-cell and cell-substrate interactions using arrays of selectively patterned flexible PDMS microposts combined with the ability to apply local chemical stimulation. Micropipette ``spritzing'', a laminar flow technique, uses glass micropipettes mounted on a microscope stage to deliver drugs to controlled regions within a cellular construct while cell traction forces are recorded via the micropost array. The pipettes are controlled by micromanipulators allowing for rapid and precise movement across the array and the ability to treat multiple constructs within a sample. This technique allows for observing the propagation of a chemically induced mechanical stimulus through cell-cell and cell-substrate interactions. We have used this system to administer the acto-myosin inhibitors Blebbistatin and Y-27632 to single cells and observed the subsequent decrease in cell traction forces. Experiments using trypsin-EDTA have shown this system to be capable of single cell manipulation through removal of one cell within a pair configuration while leaving the other cell unaffected.03/2013;
Article: Defibrillation Success with High Frequency Electric Fields is Related to Degree and Location of Conduction Block.[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: We recently demonstrated that high frequency alternating current (HFAC) electric fields can reversibly block propagation in the heart by inducing an oscillating, elevated transmembrane potential (V(m)) which maintains myocytes in a refractory state for the field duration, and can terminate arrhythmias, including ventricular fibrillation (VF). OBJECTIVE: In this study, we sought to quantify and characterize conduction block (CB) induced by HFAC fields and to determine whether the degree of CB can be used to predict defibrillation success. METHODS: Optical mapping was performed in adult guinea pig hearts (n = 14), and simulations were performed in an anatomically accurate rabbit ventricular model. HFAC fields (50-500 Hz) were applied to the ventricles. A novel power spectrum metric of CB - the loss of spectral power in the 1-30 Hz range, termed loss of conduction power (LCP) - was assessed during the HFAC field and compared with defibrillation success and VF vulnerability. RESULTS: LCP increased with field strength and decreased with frequency. Optical mapping experiments conducted on the epicardial surface showed that LCP and the size of CB regions were significantly correlated with VF initiation and termination. In simulations, sub-surface myocardial LCP and CB size were more closely correlated with VF termination than surface values. Multilinear regression analysis of simulation results revealed that while CB on both the surface and sub-surface myocardium were predictive, sub-surface myocardial CB was the better predictor of defibrillation success. CONCLUSION: HFAC fields induce a field-dependent state of conduction block, and defibrillation success is related to the degree and location of the conduction block.Heart rhythm: the official journal of the Heart Rhythm Society 01/2013; · 4.56 Impact Factor
- Biophysical Journal 01/2013; 104(2):281-. · 3.67 Impact Factor
Article: Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility.[Show abstract] [Hide abstract]
ABSTRACT: Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific cardiac disorders, enabling in vitro human disease models for mechanistic study and therapeutic drug assessment. However, a full understanding of their electrophysiological and contractile function is necessary before this potential can be realized. Here, we review this emerging field from a functional perspective, with particular emphasis on beating rate, action potential, ionic currents, multicellular conduction, calcium handling and contraction. We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease.Progress in Biophysics and Molecular Biology 08/2012; · 2.91 Impact Factor
Article: Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells.[Show abstract] [Hide abstract]
ABSTRACT: Human embryonic stem cells have emerged as the prototypical source from which cardiomyocytes can be derived for use in drug discovery and cell therapy. However, such applications require that these cardiomyocytes (hESC-CMs) faithfully recapitulate the physiology of adult cells, especially in relation to their electrophysiological and contractile function. We review what is known about the electrophysiology of hESC-CMs in terms of beating rate, action potential characteristics, ionic currents, and cellular coupling as well as their contractility in terms of calcium cycling and contraction. We also discuss the heterogeneity in cellular phenotypes that arises from variability in cardiac differentiation, maturation, and culture conditions, and summarize present strategies that have been implemented to reduce this heterogeneity. Finally, we present original electrophysiological data from optical maps of hESC-CM clusters.Progress in Biophysics and Molecular Biology 08/2012; · 2.91 Impact Factor
Article: Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model.[Show abstract] [Hide abstract]
ABSTRACT: In this study, we characterized the electrophysiological benefits of engrafting human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in a model of arrhythmogenic cardiac tissue. Using transforming growth factor-β treated monolayers of neonatal rat ventricular cells (NRVCs), which retain several key aspects of the healing infarct such as an excess of contractile myofibroblasts and slowed, heterogeneous conduction, we assessed the ability of hESC-CMs to improve conduction and prevent arrhythmias. Cells from beating embryoid bodies (hESC-CMs) can form functional monolayers which beat spontaneously and can be electrically stimulated, with mean action potential duration of 275 ± 36 ms and conduction velocity (CV) of 10.6 ± 4.2 cm/s (n = 3). These cells, or cells from non-beating embryoid bodies (hEBCs) were added to anisotropic, NRVC monolayers. Immunostaining demonstrated hESC-CM survival and engraftment, and dye transfer assays confirmed functional coupling between hESC-CMs and NRVCs. Conduction velocities significantly increased in anisotropic NRVC monolayers after engraftment of hESC-CMs (13.4 ± 0.9 cm/s, n = 35 vs. 30.1 ± 3.2 cm/s, n = 20 in the longitudinal direction and 4.3 ± 0.3 cm/s vs. 9.3 ± 0.9 cm/s in the transverse direction), but decreased to even lower values after engraftment of non-cardiac hEBCs (to 10.6 ± 1.3 cm/s and 3.1 ± 0.5 cm/s, n = 11, respectively). Furthermore, reentrant wave vulnerability in NRVC monolayers decreased by 20% after engraftment of hESC-CMs, but did not change with engraftment of hEBCs. Finally, the culture of hESC-CMs in transwell inserts, which prevents juxtacrine interactions, or engraftment with connexin43-silenced hESC-CMs provided no functional improvement to NRVC monolayers. These results demonstrate that hESC-CMs can reverse the slowing of conduction velocity, reduce the incidence of reentry, and augment impaired electrical propagation via gap junction coupling to host cardiomyocytes in this arrhythmogenic in vitro model.Journal of Molecular and Cellular Cardiology 07/2012; 53(1):15-23. · 5.15 Impact Factor
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ABSTRACT: Early afterdepolarizations (EADs) are voltage oscillations that occur during the repolarizing phase of the cardiac action potential and cause cardiac arrhythmias in a variety of clinical settings. EADs occur in the setting of reduced repolarization reserve and increased inward-over-outward currents, which intuitively explains the repolarization delay but does not mechanistically explain the time-dependent voltage oscillations that are characteristic of EADs. In a recent theoretical study, we identified a dual Hopf-homoclinic bifurcation as a dynamical mechanism that causes voltage oscillations during EADs, depending on the amplitude and kinetics of the L-type Ca(2+) channel (LTCC) current relative to the repolarizing K(+) currents. Here we demonstrate this mechanism experimentally. We show that cardiac monolayers exposed to the LTCC agonists BayK8644 and isoproterenol produce EAD bursts that are suppressed by the LTCC blocker nitrendipine but not by the Na(+) current blocker tetrodoxin, depletion of intracellular Ca(2+) stores with thapsigargin and caffeine, or buffering of intracellular Ca(2+) with BAPTA-AM. These EAD bursts exhibited a key dynamical signature of the dual Hopf-homoclinic bifurcation mechanism, namely, a gradual slowing in the frequency of oscillations before burst termination. A detailed cardiac action potential model reproduced the experimental observations, and identified intracellular Na(+) accumulation as the likely mechanism for terminating EAD bursts. Our findings in cardiac monolayers provide direct support for the Hopf-homoclinic bifurcation mechanism of EAD-mediated triggered activity, and raise the possibility that this mechanism may also contribute to EAD formation in clinical settings such as long QT syndromes, heart failure, and increased sympathetic output.Biophysical Journal 06/2012; 102(12):2706-14. · 3.67 Impact Factor
Article: Oscillation in cycle length induces transient discordant and steady-state concordant alternans in the heart.[Show abstract] [Hide abstract]
ABSTRACT: Alternans is a beat-to-beat alternation of the cardiac action potential duration (APD) or intracellular calcium (Ca(i)) transient. In cardiac tissue, alternans can be spatially concordant or discordant, of which the latter has been shown to increase dispersion of repolarization and promote a substrate for initiation of ventricular fibrillation. Alternans has been studied almost exclusively under constant cycle length pacing conditions. However, heart rate varies greatly on a beat-by-beat basis in normal and pathological conditions. The purpose of this study was to determine if applying a repetitive but non-constant pacing pattern, specifically cycle length oscillation (CLO), promotes or suppresses a proarrhythmic substrate. We performed computational simulations and optical mapping experiments to investigate the potential consequences of CLO. In a single cell computational model, CLO induced APD and Ca(i) alternans, which became "phase-matched" with the applied oscillation. As a consequence of the phase-matching, in one-dimensional cable simulations, neonatal rat ventricular myocyte monolayers, and isolated adult guinea pig hearts CLO could transiently induce spatial and electromechanical discordant alternans followed by a steady-state of concordance. Our results demonstrated that under certain conditions, CLO can initiate ventricular fibrillation in the isolated hearts. On the other hand, CLO can also exert an antiarrhythmic effect by converting an existing state of discordant alternans to concordant alternans.PLoS ONE 01/2012; 7(7):e40477. · 3.53 Impact Factor
Article: Myofibroblast-Myocyte Coupling Through Adherens Junctions Slows Cardiac Electrical PropagationBiophysical Journal 01/2012; 102(3):36-. · 3.67 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Electrical impulse propagation is an essential function in cardiac, skeletal muscle, and nervous tissue. Abnormalities in cardiac impulse propagation underlie lethal reentrant arrhythmias, including ventricular fibrillation. Temporary propagation block throughout the ventricular myocardium could possibly terminate these arrhythmias. Electrical stimulation has been applied to nervous tissue to cause reversible conduction block, but has not been explored sufficiently in cardiac tissue. We show that reversible propagation block can be achieved in cardiac tissue by holding myocardial cells in a refractory state for a designated period of time by applying a sustained sinusoidal high-frequency alternating current (HFAC); in doing so, reentrant arrhythmias are terminated. We demonstrate proof of concept using several models, including optically mapped monolayers of neonatal rat ventricular cardiomyocytes, Langendorff-perfused guinea pig and rabbit hearts, intact anesthetized adult rabbits, and computer simulations of whole-heart impulse propagation. HFAC may be an effective and potentially safer alternative to direct current application, currently used to treat ventricular fibrillation.Science translational medicine 09/2011; 3(102):102ra96. · 10.76 Impact Factor
Article: Mechanical coupling between myofibroblasts and cardiomyocytes slows electric conduction in fibrotic cell monolayers.[Show abstract] [Hide abstract]
ABSTRACT: After cardiac injury, activated cardiac myofibroblasts can influence tissue electrophysiology. Because mechanical coupling through adherens junctions provides a route for intercellular communication, we tested the hypothesis that myofibroblasts exert tonic contractile forces on the cardiomyocytes and affect electric propagation via a process of mechanoelectric feedback. The role of mechanoelectric feedback was examined in transforming growth factor-β-treated monolayers of cocultured myofibroblasts and neonatal rat ventricular cells by inhibiting myofibroblast contraction and blocking mechanosensitive channels. Untreated (control) and transforming growth factor-β-treated (fibrotic) anisotropic monolayers were optically mapped for electrophysiological comparison. Longitudinal conduction velocity, transverse conduction velocity, and normalized action potential upstroke velocity (dV/dt(max)) significantly decreased in fibrotic monolayers (14.4 ± 0.7 cm/s [mean ± SEM], 4.1 ± 0.3 cm/s [n=53], and 3.1 ± 0.2% per ms [n=14], respectively) compared with control monolayers (27.2 ± 0.8 cm/s, 8.5 ± 0.4 cm/s [n=40], and 4.9 ± 0.1% per ms [n=12], respectively). Application of the excitation-contraction uncoupler blebbistatin or the mechanosensitive channel blocker gadolinium or streptomycin dramatically increased longitudinal conduction velocity, transverse conduction velocity, and dV/dt(max) in fibrotic monolayers (35.9 ± 1.5 cm/s, 10.3 ± 0.6 cm/s [n=17], and 4.5 ± 0.1% per ms [n=14], respectively). Similar results were observed with connexin43-silenced cardiac myofibroblasts. Spiral-wave induction in fibrotic monolayers also decreased after the aforementioned treatments. Finally, traction force measurements of individual myofibroblasts showed a significant increase with transforming growth factor-β, a decrease with blebbistatin, and no change with mechanosensitive channel blockers. These observations suggest that myofibroblast-myocyte mechanical interactions develop during cardiac injury, and that cardiac conduction may be impaired as a result of increased mechanosensitive channel activation owing to tension applied to the myocyte by the myofibroblast.Circulation 05/2011; 123(19):2083-93. · 15.20 Impact Factor
- The Journal of Physiology 05/2011; 589(Pt 9):2107-8. · 4.38 Impact Factor
Conference Paper: Contactless fluorescence imaging with a CMOS image sensor.[Show abstract] [Hide abstract]
ABSTRACT: In this work, we utilize a CMOS active pixel sensor in a fluorescence imaging setup. The ability to sense small light intensity changes on top of a large baseline with spatial resolution at the subcellular scale is required in fluorescence imaging. The CMOS imager presented in (1) is perfect for this application with the ability to resolve fine features coupled with high dynamic range. By using a custom imager with a relay lens we are able to realize a dramatic decrease in device size, cost and complexity of the whole system.International Symposium on Circuits and Systems (ISCAS 2011), May 15-19 2011, Rio de Janeiro, Brazil; 01/2011
Article: Normalizing Action-Potential Morphology in Long-Term Cultures of Adult GuineaPig Ventricular Cardiomyocytes by Ca VBETA ExpressionBiophysical Journal 01/2011; 100(3). · 3.67 Impact Factor
Article: A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability.[Show abstract] [Hide abstract]
ABSTRACT: The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC) holds great promise for patient-specific cardiotoxicity drug testing, disease modeling, and cardiac regeneration. However, existing protocols for the differentiation of hiPSC to the cardiac lineage are inefficient and highly variable. We describe a highly efficient system for differentiation of human embryonic stem cells (hESC) and hiPSC to the cardiac lineage. This system eliminated the variability in cardiac differentiation capacity of a variety of human pluripotent stem cells (hPSC), including hiPSC generated from CD34(+) cord blood using non-viral, non-integrating methods. We systematically and rigorously optimized >45 experimental variables to develop a universal cardiac differentiation system that produced contracting human embryoid bodies (hEB) with an improved efficiency of 94.7±2.4% in an accelerated nine days from four hESC and seven hiPSC lines tested, including hiPSC derived from neonatal CD34(+) cord blood and adult fibroblasts using non-integrating episomal plasmids. This cost-effective differentiation method employed forced aggregation hEB formation in a chemically defined medium, along with staged exposure to physiological (5%) oxygen, and optimized concentrations of mesodermal morphogens BMP4 and FGF2, polyvinyl alcohol, serum, and insulin. The contracting hEB derived using these methods were composed of high percentages (64-89%) of cardiac troponin I(+) cells that displayed ultrastructural properties of functional cardiomyocytes and uniform electrophysiological profiles responsive to cardioactive drugs. This efficient and cost-effective universal system for cardiac differentiation of hiPSC allows a potentially unlimited production of functional cardiomyocytes suitable for application to hPSC-based drug development, cardiac disease modeling, and the future generation of clinically-safe nonviral human cardiac cells for regenerative medicine.PLoS ONE 01/2011; 6(4):e18293. · 3.53 Impact Factor
Top Journals
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- • Department of Biomedical Engineering
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She Ain't Messin With No Broke N***as: Kanye Ready To Drop A Bomb On Kimmy Cakes! [Video]
Looks like Yeezy pulled out all the stops!
True Or False? Has Kanye West Been Cheating On Kimmy Cakes With This Slorey Brunette Look Alike???
Why do people always "cheat" on Kim with broads who look exactly like her? LOL!
Fawk You, Pay Me! 18-Year-Old Who Kanye Went H.A.M. On For Insulting Kimmy Cakes Wants To Be Paid In Cash
Kanye's catch fade recipient wants to skip the courts and go straight to the stacks…


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text: Admissions & Aid / Statistics & Profile print Statistics & Profile ABA Required Disclosures Admission Statistics Recent Placements Attrition Rate Graduation Rate Bar Pass Rate Total Enrollment Statistics Our History 2014 Total J.D. Enrollment As of October 5, 2014, our total enrollment was 1,119. Total number of students Percentage of the student body Full-time students Accelerated 2-Year 30 2.7% Standard 3-Year 851 76.0% Total 881 78.7% Part-time students Extended 4-Year 238 21.3% Men 606 54.2% Women 513 45.8% Students of color 305 27.3% Meet our 2014 entering J.D. Class! Related Links: Employment Statistics Our Strategic Edge Future Students News Join Our Admissions Social Networks Have questions? We have answers. Admissions Office One Boerum Place, 4th Floor Telephone: (718) 780-7906 Fax: (718) 780-0395 Email: email@example.com Office Hours Monday-Friday 9:30 a.m. - 5:30 p.m. and until 6:00 p.m. Tuesdays during the academic year. Admitted Applicants Please log on to BLSConnect to access important information about your admission to the Law School. New App Tour Take a guided walking tour of our Campus by downloading our free app. iPhone. Droid. More info. Start Here Brochure 2013-14 BLS Start Here Why BLS? Beautiful and affordable housing, guaranteed during your first year, allows you to relax and focus on your studies.


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MJM is the best magic supplier there is! My order arrived in just a few days, and now I'm getting 10% percent off on all of my purchases. MJM has...Read More ->
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November 28, 2014
Placing a classified advert in a music paper, Jimmy auditions a number of wannabes before finalising the new line up who he names The Commitments.
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Catt wants England to emulate All Blacks
ESPN Staff
October 26, 2012
Part of the England coaching team pose for the cameras at the launch of the autumn internationals yesterday © Getty Images
England coach Mike Catt wants the team to emulate the All Blacks and develop a ruthless streak to their game.
Catt and the rest of the England staff took in New Zealand's 32-16 win over South Africa in Soweto back on October 6 and they were treated to an All Blacks display which saw them down the Boks four tries to one. The Kiwis were forced to soak up plenty of South African pressure but when they got on the front-foot and got into Springbok territory, they put their southern hemisphere counterparts to the sword.
And Catt, who was speaking at the unveiling of the England squad for the autumn Tests, wants the team to develop a similar outlook to the All Blacks.
"You look at New Zealand and the way they get one opportunity and score it," Catt said. "New Zealand are very good and accurate at what they do. They are on the front foot a lot of the time and they can bring the big guys into the game. Everybody is going to want to get to that situation. It is how we get there and how long it takes us to get there.
"I am not saying it's not there (in the English players) but we have got to get to that, having that belief we can do it. It is about seeing the opportunities and understanding it. That is my role. From an attacking point of view, I want to see speed of the ball and movement of the ball."
England named two uncapped players in their squad for the autumn internationals on Thursday with Saracens' Mako Vunipola and Leicester Tigers' Tom Youngs getting the nod. And the coaching team also opted to recall Wasps' James Haskell and Quins flyer Ugo Monye, who comes into the squad for the injured Ben Foden.
Monye last played for England back in 2010 and coach Andy Farrell hopes to see the Harlequins winger continue his good run of club form on the Test stage. "Ugo has been in great form," Farrell said. "He is hungry to get back to Test level and prove his worth. You can see that with his performances."
© ESPN Sports Media Ltd.
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The time for tinkering is over - England must nail their colours to the mast in key positions, writes Phil Vickery
Gatland should learn from Joe Schmidt
"New Zealand-born Joe Schmidt has forged the Irish into a street-smart, well- prepared side," John Mitchell on the Irish renaissance
"I am bored of hearing 'I can't fault the effort'. Let us take that for granted and look for some quality." John Taylor writes
Damned if they do, damned if they don't
Reports comparing the 2014 Wallabies with their rabble-like predecessors of 2005 are unfair and self-serving, Greg Growden reports


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As we cruised along the fjord, we discovered that the temperatures out on decks nine and ten were usually a fair bit colder than out on our verandah. No doubt that had something to do with the fact that our verandah was very well sheltered, whereas the upper decks of the Wonder were very much open to the elements. We quickly learned not to judge the temperature by stepping out on to our balcony, as all too often, we were then greeted by a nasty shock when we headed up to the open decks.
Disney, as you'd expect, have taken this into account, and had hot chocolate waiting for the passengers out on deck, and we saw plenty of blankets lying around, too. If you did want to retreat back to your room, Disney had taken care of that as well. The narration from the ship's resident naturalist that could be heard on the outer decks was also available on one of the TV channels in your stateroom, so you didn't have to miss anything. We found it fascinating to watch the scenery go by, and at the same time, learn more about how nature shaped this beautiful part of the world.
As we moved further along the fjord, we started to see icebergs, sheared off no doubt from the glacier at the end. They had floated some distance, and some of them were so close to our room that you didn't even have to use the zoom function on your camera to photograph them! I had no end of admiration for our captain, navigating his way through this icy minefield. The stories we'd heard about icebergs in the past, where what you see on top of the water is only a small proportion of it, turned out to be frighteningly true. We could see massive chunks of ice underneath the water, much larger than what was poking out above.
As you cruise along, you tend to see trees located near the shoreline, with sheer rock cliffs above them. It really feels as if you're in the middle of nowhere, with silence outside, except for the occasional distant roar of a waterfall. You continue to glide along gracefully through the fjord, with us assuming that any minute now we'd catch a glimpse of the twin Sawyer Glaciers, North Sawyer and South Sawyer, at the fjord's far end. In fact, it took us over an hour before we caught our first sight of them in the distance.
As we moved along, so the glacier loomed larger. We could see the Carnival Spirit in front of us, and she was completely dwarfed by the glacier behind it. From a distance, it looked as if the ice was completely blue, like many of the icebergs we had seen on the way here, but closer up, you could see black shadows, and brilliant white patches, particularly whenever the sun's rays caught it. Once again, you got a very different perspective from the top decks as compared to our room lower down. From our room, you were no longer looking down on the glacier, so it seemed so much bigger and intimidating.
As we looked, we could see black dots on the icebergs floating nearby. Thank goodness someone had thought to bring binoculars, as we found out that these dots were in fact harbor seals! That was the only wildlife sighting we had of the day, although we were aware that other passengers had spotted much more than we had, thanks to the naturalist's narration.
Soon, we were turning and heading back out through the fjord, enjoying more stunning scenery, and as we started to lose the light, we were treated to a beautiful sunset. It had been a truly wonderful day, absolutely packed full of amazing sights. Unlike other cruise lines, Disney doesn't offer excursions for the Tracy Arm Fjord, with the Carnival Spirit offering guests the chance to board a smaller boat and get much closer to the glacier. Despite this, it didn't detract from the enjoyment of the day. Somehow, even though it technically wasn't a port of call, we got probably just as much, if not more, enjoyment from this day, as all our other days in port. The Tracy Arm Fjord is definitely one of the highlights of the Alaskan cruises–be sure not to plan too much for that day, as you'll want your free time to take it the breathtaking views in front of you and to either side.
Alaska cruise - Tracy Arm Fjord
Beautiful blue water, coloured by the glaciers in Tracy Arm Fjord. - photo by chezp
About the Author: Cheryl and husband Mark live in England and love to travel, particularly to Disney, and they have made numerous visits to destinations across America and Europe. They recently completed their tour of every Disney theme park around the world, which culminated in their visit to Japan, including the Tokyo Disney Resort. Click here to view more of Cheryl's articles!
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a bit worried about activities for young adults
by LLP14
26 Nov 2014 at 8:27am
We will be on the Magic in just 10 days! Our DS is 23, and I am concerned that he may not find enough to do, or people his age. DD is 25, but a huge...
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packing for cruise/wdw trip. need help please
by LLP14
24 Nov 2014 at 6:56am
I am usually a pretty efficient packer, but with the variable weather forecast for the Western Caribbean and WDW area in early to mid December I...
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Turkey - St. John's Basilica by chezp -- DCL Photo of the Day (11-22-2014 12:...
by Jennifer Marx
23 Nov 2014 at 12:50am
Here's the latest photo of a Disney cruise ship or one of its ports of call from the PassPorter Photo Archive (http://www.passporter.com/photos): ...
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Turkey - Kusadasi by chezp -- DCL Photo of the Day (11-22-2014 11:39 AM)
by Jennifer Marx
22 Nov 2014 at 12:40pm
Here's the latest photo of a Disney cruise ship or one of its ports of call from the PassPorter Photo Archive (http://www.passporter.com/photos): ...
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Recent cruisers...
by robbydj13
21 Nov 2014 at 10:39am
What has been the on ship entertainment during you recent cruises? Like the movies they show, or special entertainers? Just curious as we will be...
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Narrow your search
No matter where you're headed, these iOS and Android apps can help you get there and find things to do when you arrive.
It's got the look, the power and the noise. The new Jaguar F-Type R Coupe is the Jag we've all been waiting for.
If you can afford a first-class seat, this 160 mph bullet train promises a plush ride to Nagano and the Sea of Japan.
The 394-unit apartment community, located off of High 101 in Menlo Park, will cater to the all-inclusive expectations of today's tech workers.
In an effort to keep prices down and sales up, TV companies are pushing TVs with "fake" refresh rates. Know your terms and tech to make sure you're really getting what you think you're paying for.
AT&T will soon show off how small cell technology can improve network capacity and coverage in Walt Disney theme parks.
This number/letter combo is the key to film-like movies shown closer to the way the director intended.
Nintendo is dropping a bunch of titles into its budget range too, so gaming is about to become more affordable.
Shopping for an athletic type this Christmas? Get a sporty victory high-five from them by gifting one of these ingenious gadgets.
Oakley's new Airwave goggles feature a heads-up display that can show a variety of mapping and performance data in real time. You can even see where your friends are while you make a jump.


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- What's on ABC Jazz radio now?
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ABC Jazz Home > Features
ABC Jazz celebrated International Jazz Day 2014 with a special broadcast of Sandy Evans' tribute to Charlie Parker, 'Testimony'.
More features
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A big week at Rudy's
With Coltrane's 'A Love Supreme,' about to turn 50, we look back at some of the big-name albums that were recorded in late 1964 at RVG's.
'OverTime' The Vanguard Jazz Orchestra
The Vanguard Jazz Orchestra celebrates the music of and life of the trombonist and composer Bob Brookmeyer.
2014 London Jazz Festival review
Jessica Nicholas has been abroad in the UK, and whilst visiting the London Jazz Festival, she dropped us a line with news from the event.
'Solo' Paul Grabowsky
Despite a long and distinguished career, Paul Grabowsky has never released a solo piano album. Until now...
'Round Tripper' Lisa Parrott
Aussie saxophonist Lisa Parrott has been working in NY since the 90s and we've got her new album.
SIWJF Highlights
The 2014 Sydney International Women's Jazz Festival has concluded. Check out some of our photos and interviews from the festival.
'Puzzles' Steve Barry
Pianist Steve Barry has a new album out and is offering one of the tracks as a download this week.
2014 Wangaratta Next Gen Showcase
Hear one of the closing gigs at the 2014 Wangaratta Jazz and Blues Festival, which put the spotlight on Australia's emerging jazz leaders.
Highlights from Wang 2014
The 25th Wangaratta Jazz and Blues Festival has come and gone. Check out our photos, videos, interviews and broadcasts online now.
SIWJF Artist Preview: Dee Alexander
Chicago-based Dee Alexander, in Australia for the 2014 Sydney International Women's Jazz Festival and previewed here by Jessica Nicholas.


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- Posts: 345
Quote from Iceyshadows »
Really love this addon. I've been using it since vanilla.
Just a very small question about the display of a mob's HP
I notice that the unitframe can only hold up to a display such as 600.4M/800.2M (3 digit million with a decimal digit)
I haven't seen a mob yet that has 1billion HP yet, but will it show up as something like 1000.3M/100...(the last part getting cut off due to unitframe space) or is it set to show up as 1.0G/1.0G (for 1 billion HP using SI suffixes)
Extend your frame width to increase the showing space for such long strings, but yes, in one day we needed bigger suffixes and for some locales strings about it. :p


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We've heard rumblings in the past weeks that the F82 M4 coupe had begun its public testing rounds and our spies have now spotted it for the very first time!
The prototype wears the typical heavy camouflage of early stage mules, but there's plenty to analyze. There's little doubt this is the M version of the upcoming 4 Series coupe. There are the signature M quad exhausts, the flared fenders, signature blue M brakes, wide tires, and M6 steering wheel.
Both the front and rear fenders on the … CONTINUED
The F32 4 Series Coupe and F33 4 Series Convertible have finally shown one of its most important signature design elements (and on any BMW) – the kidney grilles!
As expected, the kidney grilles of the coupe are sportier (thinner, shapelier and wider) than that of the F30 3 Series sedan. A close look reveals a different number of slats and differing designs for the grilles on each side – 11 flatter slats on the driver side versus 9 'kinked' slats on the passenger side. We are … CONTINUED
New photos of the mystery shrouded BMW model spotted at the BMW Museum shows that it is indeed a coupe shape, ruling out the possibility that it is the F80 M3 sedan. However, new info and clues provide some guidance on what it may be.
The car is confirmed to have quad exhausts, which confirms that it's an M model. We can think of two upcoming M models expected in the next 2-3 years bearing the shape and size suggested by the photos – the F82 M4 … CONTINUED
A mystery BMW model appeared at the BMW Museum a bit over a month ago, shrouded under a big blue tarp. It's yet to be positively identified, but could this possibly be the next generation F80 M3 sedan or F82 M4 coupe?
There's not much to go off of by way of the sparse photos, but the one part of the car that can be partially seen – the wheels, happen to match the wheels that have been spotted on the F80 M3 sedan prototypes from our … CONTINUED
Someone at BMW M HQ in Garching has been gabbing and has let on to Bimmerfile that the next generation 2014 F80 M3 may be getting electric power steering instead of the hydraulic power steering that M cars have always been equipped with (even with the latest M5 and M5).
Porsche's new 911 991 is equipped with EPS which has been praised, which likely gives manufacturers such as BMW hope that a sporty EPS system can be developed for their most sporty cars – the … CONTINUED
BMW has been busy trademarking. Below is a list of some recent BMW trademark filings for future potential models. Remember, just because a manufacturer registers a trademark does not mean that the model will necessarily come to fruition. But, it makes for some fun speculation and certainly paints a rough map of what potential future models we may see out of Munich.
Recent Trademark List:
2 Series Active Tourer
We can finally confirm that the next generation M3 (F80 / F82) will be powered by an inline 6 cylinder engine. We spoke to the President of BMW North America, Mr. Ludwig Willisch, at the ongoing M6 convertible / 6 Gran Coupe US press launch and he has officially confirmed that the next generation M3′s engine will indeed feature an inline 6 layout and not a V6.
Until now, there has been no official confirmation (nor denial) from BMW on whether the F80 sedan and F82 coupe's … CONTINUED
Now that the new M6 coupe/convertible and M5 have all debuted, our thoughts often turn to the next M3 – the F80. And although we've previously rendered the F80, here is our take on what the next generation M3 may resemble now that the M6 has been revealed. So far, the multitude of F80 M3 spy photos / videos we've posted have not been very telling in terms of the lower front bumper design, but we've used our imagination based on the new M6 and M5 … CONTINUED
We had the chance to speak to BMW NA M Brand Manager Matt Russell and BMW M Marketing Director Thomas Schemera at the 2012 NYIAS about many things M. We covered some hot topics/models, including the M5, M6, M3 (current and future generation) and M Performance Automobiles.
Can you tell us about the changes to the 2013 M5 from the 2012 M5? Why the wait for the 2013 model year for the US market?
It's nothing major. It's small things; it's electronics underneath, little computer things. … CONTINUED
We had the opportunity to sit down with the gracious Dr. Friedrich Nitschke, current BMW M GmbH President, at the 2012 Geneva Motorshow last week. We were primarily interested in discussing future M models and developments and here's what we are able to report.
Is it safe to assume that will there will be a successor to the popular 1M coupe?
We sold more than 5000 units worldwide and we are thinking for a successor, but we haven't made a decision yet.
We've seen next generation M3 … CONTINUED
Two days ago we brought you spy photos of the 2013 BMW F80 M3 sedan being cold weather tested in Sweden. We've now put together some live video footage of the F80 M3 making its rounds on BMW's winter test track.
It's been a while since the last F80 M3 spy photos, but we've now spotted the next generation F80 BMW M3 Sedan undergoing winter testing in Sweden. Compared to the previous spyshots, the F80 prototype has lost a bit of camouflage – mostly at the rear which now shows the tail lights in their full glory. The car's appearance is low, wide, and impressive with massive fender flares. The M3′s kidney grilles are also very obviously styled in a sleeker/sportier shape than the F30 3 series … CONTINUED


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Paige with her people Emily and Molly,
The St. Louis Senior Dog Project is a not-for-profit dog rescue organization specializing in older dogs but taking in and finding homes for dogs of all ages...even puppies. Meet your new best friend 11 to 3 Saturday, November 22 in the Kirkwood Petco. To see which dogs will be there plus other available dogs, go Here.
Are you an Amazon shopper? If you are, you can help St. Louis Senior Dog Project while you shop online. Start your shopping at our Amazon Smile URL.
My favorite three-letter word is "Joy." I see it quite a bit when people tell me about the dog they adopted from St. Louis Senior Dog Project. They say the dog, once homeless or unwanted, is now bringing joy into their lives.
That's the case with Paige, above, who didn't love sporting reindeer antlers for the picture, but certainly loves her new home where Emily and Molly spoil her daily.
Paige's was one picture I received this week. Another came from Hillary and Steve who adopted Winnie (now Stella) in 2013. Stella is also bringing "so much joy" to her people. "I couldn't have asked for a better dog," wrote Hillary.
I first saw Stella when she was brought into Jefferson County Animal Control in a humane trap that had been set out to catch her. Neighbors had seen her running about but couldn't catch her. This tiny dog was clearly terrified.
All that fear disappeared quickly, and Stella found her new home where Hillary and Steve are spoiling her seriously.
We do have plenty of other dogs waiting to bring joy to their new homes.
This week I took in a couple dogs from Jefferson County Animal Control (JCAC). One is Enzo, an Italian Greyhound/ Rat Terrier mix. He likes to keep warm by burrowing under blankets. Here's how he looked at the shelter when I picked him up. He's about 9 years old and feeling much better
Also new to my place is Homer, and your guess is as good as mine as to the mix in this 2 year old who was also found at JCAC.
I also took in some dogs from a breeding facility that was shutting down. The dogs were being sold at auction, and some were having trouble finding new homes. I'm not sure I can afford them, but sometimes it's hard to say no to dogs that have never yet had the chance to be a pet.
Another adoption event Saturday. Hope to see you there.
Ellen Ellick
St. Louis Senior Dog Project