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The 51-year-old will succeed Liam Brady in the role
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Publications (6)31.96 Total impact
Article: Rationale for the opposite stereochemistry of the major monoadducts and interstrand crosslinks formed by mitomycin C and its decarbamoylated analogue at CpG steps in DNA and the effect of cytosine modification on reactivity.[Show abstract] [Hide abstract]
ABSTRACT: Mitomycin C (MMC) is a potent antitumour agent that forms a covalent bond with the 2-amino group of selected guanines in the minor groove of double-stranded DNA following intracellular reduction of its quinone ring and opening of its aziridine moiety. At some 5'-CG-3' (CpG) steps the resulting monofunctional adduct can evolve towards a more deleterious bifunctional lesion, which is known as an interstrand crosslink (ICL). MMC reactivity is enhanced when the cytosine bases are methylated (5 MC) and decreased when they are replaced with 5-F-cytosine (5FC) whereas the stereochemical preference of alkylation changes upon decarbamoylation. We have studied three duplex oligonucleotides of general formula d(CGATAAXGCTAACG) in which X stands for C, 5MC or 5FC. Using a combination of molecular dynamics simulations in aqueous solution, quantum mechanics and continuum electrostatics, we have been able to (i) obtain a large series of snapshots that facilitate an understanding in atomic detail of the distinct stereochemistry of monoadduct and ICL formation by MMC and its decarbamoylated analogue, (ii) provide an explanation for the altered reactivity of MMC towards DNA molecules containing 5MC or 5FC, and (iii) show the distinct accommodation in the DNA minor groove of the different covalent modifications, particularly the most cytotoxic C1α and C1β ICLs.Organic & Biomolecular Chemistry 02/2012; 10(8):1543-52. · 3.57 Impact Factor
Article: Mechanistic insight into the catalytic activity of ββα-metallonucleases from computer simulations: Vibrio vulnificus periplasmic nuclease as a test case.[Show abstract] [Hide abstract]
ABSTRACT: Using information from wild-type and mutant Vibrio vulnificus nuclease (Vvn) and I-PpoI homing endonuclease co-crystallized with different oligodeoxynucleotides, we have built the complex of Vvn with a DNA octamer and carried out a series of simulations to dissect the catalytic mechanism of this metallonuclease in a stepwise fashion. The distinct roles played in the reaction by individual active site residues, the metal cation and water molecules have been clarified by using a combination of classical molecular dynamics simulations and quantum mechanical calculations. Our results strongly support the most parsimonious catalytic mechanism, namely one in which a single water molecule from bulk solvent is used to cleave the phosphodiester bond and protonate the 3'-hydroxylate leaving group.ChemBioChem 11/2011; 12(17):2615-22. · 3.74 Impact Factor
Article: XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.[Show abstract] [Hide abstract]
ABSTRACT: Trabectedin and Zalypsis are two potent anticancer tetrahydroisoquinoline alkaloids that can form a covalent bond with the amino group of a guanine in selected triplets of DNA duplexes and eventually give rise to double-strand breaks. Using well-defined in vitro and in vivo assays, we show that the resulting DNA adducts stimulate, in a concentration-dependent manner, cleavage by the XPF/ERCC1 nuclease on the strand opposite to that bonded by the drug. They also inhibit RNA synthesis by: (1) preventing binding of transcription factors like Sp1 to DNA, and (2) arresting elongating RNA polymerase II at the same nucleotide position regardless of the strand they are located on. Structural models provide a rationale for these findings and highlight the similarity between this type of DNA modification and an interstrand crosslink.Chemistry & biology 08/2011; 18(8):988-99. · 6.52 Impact Factor
Article: Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations.[Show abstract] [Hide abstract]
ABSTRACT: The difference in melting temperature of a double-stranded (ds) DNA molecule in the absence and presence of bound ligands can provide experimental information about the stabilization brought about by ligand binding. By simulating the dynamic behaviour of a duplex of sequence 5'-d(TAATAACGGATTATT)·5'-d(AATAATCCGTTATTA) in 0.1 M NaCl aqueous solution at 400 K, we have characterized in atomic detail its complete thermal denaturation profile in <200 ns. A striking asymmetry was observed on both sides of the central CGG triplet and the strand separation process was shown to be strongly affected by bonding in the minor groove of the prototypical interstrand crosslinker mitomycin C or the monofunctional tetrahydroisoquinolines trabectedin (Yondelis), Zalypsis and PM01183. Progressive helix unzipping was clearly interspersed with some reannealing events, which were most noticeable in the oligonucleotides containing the monoadducts, which maintained an average of 6 bp in the central region at the end of the simulations. These significant differences attest to the demonstrated ability of these drugs to stabilize dsDNA, stall replication and transcription forks, and recruit DNA repair proteins. This stabilization, quantified here in terms of undisrupted base pairs, supports the view that these monoadducts can functionally mimic a DNA interstrand crosslink.Nucleic Acids Research 07/2011; 39(18):8248-57. · 8.81 Impact Factor
Article: PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.[Show abstract] [Hide abstract]
ABSTRACT: PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In this study we have characterized the interactions of PM01183 with selected DNA molecules of defined sequence and its in vitro and in vivo cytotoxicity. DNA binding characteristics of PM01183 were studied using electrophoretic mobility shift assays, fluorescence-based melting kinetic experiments and computational modelling methods. Its mechanism of action was investigated using flow cytometry, Western blot analysis and fluorescent microscopy. In vitro anti-tumour activity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and the in vivo activity utilized several human cancer models. Electrophoretic mobility shift assays demonstrated that PM01183 bound to DNA. Fluorescence-based thermal denaturation experiments showed that the most favourable DNA triplets providing a central guanine for covalent adduct formation are AGC, CGG, AGG and TGG. These binding preferences could be rationalized using molecular modelling. PM01183-DNA adducts in living cells give rise to double-strand breaks, triggering S-phase accumulation and apoptosis. The potent cytotoxic activity of PM01183 was ascertained in a 23-cell line panel with a mean GI(50) value of 2.7 nM. In four murine xenograft models of human cancer, PM01183 inhibited tumour growth significantly with no weight loss of treated animals. PM01183 is shown to bind to selected DNA sequences and promoted apoptosis by inducing double-strand breaks at nanomolar concentrations. The potent anti-tumour activity of PM01183 in several murine models of human cancer supports its development as a novel anti-neoplastic agent.British Journal of Pharmacology 11/2010; 161(5):1099-110. · 5.07 Impact Factor
Article: Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.[Show abstract] [Hide abstract]
ABSTRACT: Zalypsis is a new synthetic alkaloid tetrahydroisoquinoline antibiotic that has a reactive carbinolamine group. This functionality can lead to the formation of a covalent bond with the amino group of selected guanines in the DNA double helix, both in the absence and in the presence of methylated cytosines. The resulting complex is additionally stabilized by the establishment of one or more hydrogen bonds with adjacent nucleotides in the opposite strand as well as by van der Waals interactions within the minor groove. Fluorescence-based thermal denaturation experiments demonstrated that the most favorable DNA triplets for covalent adduct formation are AGG, GGC, AGC, CGG and TGG, and these preferences could be rationalized on the basis of molecular modeling results. Zalypsis-DNA adducts eventually give rise to double-strand breaks, triggering S-phase accumulation and apoptotic cell death. The potent cytotoxic activity of Zalypsis was ascertained in a 24 cell line panel. The mean IC(50) value was 7nM and leukemia and stomach tumor cell lines were amongst the most sensitive. Zalypsis administration in four murine xenograft models of human cancer demonstrates significant tumor growth inhibition that is highest in the Hs746t gastric cancer cell line with no weight loss of treated animals. Taken together, these results indicate that the potent antitumor activity of Zalypsis supports its current development in the clinic as an anticancer agent.Biochemical pharmacology 05/2009; 78(2):162-70. · 4.25 Impact Factor
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University of Alcalá
Alcalá de Henares, Madrid, Spain
- Department of Physiology, Biochemistry and Molecular Biology

subset: commoncrawl


text:
Well yesterday was dryland practice- the first I ever attened. I am telling you those girls can work out. We did this jog/run/sprint thing for 15 or more minutes that killed me. Thankfully I was not the only person who looked like they were about to collapse. There were other excerises there too of course but that was the main killa. Man, my head was pounding - I guess that shows how out of shape I am.
Then I think I drank way to much water AFTER practice because about 4 hours after working out I woke up with a terrible headache and had to run to the bathroom and I lost my stomach.
Everytime I try to exert myself something like this happens- I get a headache, gut ache, and puke. Is this normal??
Anyhow I am determined to go to the next practice and do it all over again, one day hopefully I will beable to function afterwards. I think I will also run a bit more during the day so that its not such a shock to my body.
Thats it for me...
wooo...my first blog too.
Well today was the first day of classes which look as if they might be long and grueling. I sit on my butt for 6+ hours listening to the instructors drone on.
So far today is going well- I have stuck to my calorie intake and have enough points saved up for a nice dinner. Yay!


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The National Archives and Records Administration created and filled three new positions in its recent restructuring — Tom Mills as chief operating officer; Analisa Archer as chief human capital officer; and Paul Wester as chief records officer — the agency has announced.
Archivist of the United States David Ferriero also announced formation of a new open government unit to use Web 2.0 and digital media and a new performance and accountability unit.
"I expect the National Archives to be a leader in open government, electronic records management and organizational effectiveness," Ferriero said. "Putting the customer at the center of all we do, this new structure will enable us to build an open, inclusive work environment that encourages staff learning and creativity, invests in innovation, and engages all staff in continuously improving services."
Mills previously was assistant archivist for regional records services, while Archer was formerly director of human resources services and Wester was director of the modern records program.
Four additional positions on the leadership team will be filled in the near future, Ferriero said.
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You are in... Forums > Discuss This > MotoGP > Poll: Will Cal Crutchlow maintain his MotoGP form?
MCN says:
Cal Crutchlow scored another brilliant fourth place in last weekend's MotoGP, making it three fourths in a row if you count the final race of last season. Is this enough to count as form? Can we officially get excited about a bonafide British front-runner yet?
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Nov 09
Posts: 315
diceman23 says:
If Cal can maintain his form for the next couple of races that should be enough to give him access to factory updates as they arrive. Assuming (yes I'm aware what happens when you assume) that happens and Spies continues to have problems. Cal should not only maintain his form but should (another dangerous word) be gunning for a factory seat.
I agree with other bit bloody early to be having a poll on his form MCN. Boys having a blinder let him and us enjoy it.
Pass on Nicky was fantastic, no quarter given, no apologies, no fear Cal's there to race with the big boys.
Oct 09
Posts: 201
ThePornstar says:
Cal was 2.5 seconds off the win in race 2 of the 1000's, on a statelite bike.....! Casey said he thought it was his best race ever.... Lorenzo and Pedrosa own Jerez, and yet Cal was right up Dani's tailpipe for the whole race.
And he also set the fastest lap of the race.
No point in building Cal up so you can all shoot him down. He's the real deal. He has won races in WSS, WSB, & BSB and sits 4th in the world currently.
Will his form continue? Yeah, and then he'll get the factory job.
Go down the bookies and get a £10 on him for a pdium at Estoril.
Jul 08
Posts: 1612
Bob Buttamasangy says:
Pornstar, calm down buddy!
It's the English way don't yer know?
Nov 08
Posts: 129
phinmac says:
Wil Crutchlow be replacing Spies next year in the factory spot?
That should be WILL Crutchlow be replacing Spies at the factory spot?
Aug 10
Posts: 583
shawno76 says:
Hardest man alive (or most dangerous man alive) has been widely disputed and generally falls into the light/heavyweight camp in UFC or K1 (prefer old school heroes like Don Frye, Shamrock, Kimo, Severn, Houst etc.).. anyway got me thinking after Cal and Tony Stark got in that little Podium tussle after Cal sprayed him with Champers (cuz he had a cold.. haha). Anyway, I think Jamie Whitham said something about Cal being a stocky machine who would cause Stark a few issues if they exchanged knuckle bones. I tend to agree, he has those nutter eyes (softened with a warm smile). So, a better poll is:
Could Cal Despatch every other rider in the garage with Coventry Dragon Punches? As Paul Kaye said,"I don't want to see any of this Jackie Chan Bollox"
Dec 09
Posts: 7
timydg says:
how disgraceful are you MCN. since Cals superb race result in Jerez you have not written any article about him instead concentrating on stoner and others, instead you question his performance in a silly poll instead of writing an article about his incedible performance and potential which we have not seen the the likes of since foggy days. Hang your head in shame MCN.
Jun 11
Posts: 942
Moaner says:
Ha ha - Still makes me laugh seeing Biaggi hopping off the podium like a little bitch, flinging his handbag and trying to cuddle Cal... You could see when Cal realised Biaggi was actually being serious he was like "Fuck you" ha ha... How he didn't lay him out i don't know...
Here it is for those who want a laugh.. Biaggi acting like a Girl
Once Cal is on a machine that is capable of running right at the front then he will be pissing Stoner and Lorenzo right off... They thought Rossi was a bastard with his fairing bashing but they aint seen the worst of it.... Just wait till Cal gets them elbows out and starts swapping some paint with em.... ha ha, i can hear the crying now.... Bring it on!
[This Reply has been modified by the Author]
Posts: 2494
supermario says:
why peeps are getting they're knickers in a knot over this poll. MCN are trying to get us to participate by getting our points of view. Then, a few days later the results of the poll, along with a few reader comments and an article appear in the paper. Whats the issue? I think its good.
Feb 09
Posts: 515
billysollocks says:
Cal seems to be gaining in strength, ability and self belief. How about us all getting behind him and supporting his efforts? Good luck for the rest of the season, it may turn Moto GP into something worth watching!!!!!!
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Showcasing imaginative Nuevo Latin cuisine, deseo's (deseo is Spanish for "desire") menu features a distinctive and skillfully blended combination of flavors to create delicious dishes that are bold and intriguing. This style of cooking takes traditional Latin American dishes and reinvents them using European and American cooking techniques and often non-traditional ingredients. The perfect start to dinner at deseo is to "descansar" or "relax" with a freshly created cocktail at the adjacent Muddle Bar, which specializes in blending fresh fruits (mango, pineapple, raspberries, strawberries, blueberries and more) with fresh herbs (basil, tarragon, mint and more) along with your favorite spirit for the perfect pre-dinner cocktail.Continued
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Deseo at the Westin Kierland Resort & Spa reviews from OpenTable diners
83 reviews since July 27, 2014
- Food4.6Service4.5
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fit for foodies (62)special occasion (56)romantic (35)notable wine list (27)great for outdoor dining (20)good for groups (17)neighborhood gem (14)hot spot (8)scenic view (6)vibrant bar scene (4)kid-friendly (3)late-night find (3)great for lunch (1)Show More
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- Special flavorable Latin entreesColoradoFanDined on 10/21/2008Special flavorable Latin entrees and the beautiful selection of ceviche make this a delightful change from the usual.Special Features:
- Absolutely exceeded expectations.PattyoVIPDined on 10/20/2008Absolutely exceeded expectations. The ceviches are not to be missed. I think we tried them all. The Hamachi was incredible. As was the lobster and the lobster tacos. We can't wait to go back!Special Features:
- We had asked for a romanticOpenTable Diner Since 2007Dined on 10/18/2008We had asked for a romantic table since we were celebrating our anniversary and were intitially led to a tiny table in the middle of the room next to a large group that included little kids. I like little kids, but not on my anniversary! We asked to be moved outside and had a nice table overlooking the golf course. The waiter was knowledgeable and the food was very good.Special Features:
- Very good ecclectic latinOpenTable Diner Since 2006Dined on 10/9/2008Very good ecclectic latin american food. Food quality and presentation was outstanding. I recommend the appitizer sampler of cerviche as well as the chocolate cigar desert. Both were standouts and unusual creations.Special Features:
- Excellent food and service.OpenTable Diner Since 2008Dined on 10/8/2008Excellent food and service. The ceviche was exceptional! The rack of lamb tender and tasty. We'll return to try more dishes.Special Features:
- Over rated. The wait staffkathyzVIPDined on 10/3/2008Over rated. The wait staff was stretched thin - ours was very attentive in the beginning, then disappeared after she took our order. The courses were delivered by others after long waits in between. No explanation or apology. The food was outstanding with the exception of the sea bass. It tasted like it was over saturated in oil, perhaps not cooked at a high enought temperature? Loved the artist in residence and sorry we did not make a purchase with him.Special Features:
- The food and service wereOpenTable Diner Since 2014Dined on 9/29/2008The food and service were both excellent. It has a Cuban theme. You'll love the cerviches. Three of us had the Ecuadorian Cerviche and one of us had an ahi tuna which he loved. Everyone loved their dinners which comprised of 2 different fish dinners (Mahi Mahi and Bass), steak and a lamb dish.Special Features:
- It was a real treat. LoveddaynaDined on 9/26/2008It was a real treat. Loved the atmosphere, service and food. Very generous servings, all great quality.Special Features:
- Ceviche was exceptionallyOpenTable Diner Since 2007VIPDined on 9/20/2008Ceviche was exceptionally good - very fresh. Outdoor dinning can be very intimate and romantic in certain locations. Decor was very chic, but it seems like everyone has that style and it is getting a little bit overused. Service was decent. Desert was only fair in flavor, but the platings were very pleasing and creative - a nice way to end a meal!Special Features:
- The meal was exceptional,OpenTable Diner Since 2003Dined on 9/20/2008The meal was exceptional, and absolutely delicious. My husband and I will definately be back.Special Features:
- The food was definitely outstandingGaileeVIPDined on 9/20/2008The food was definitely outstanding with sauces and flavors we totally enjoyed. The decor is just a little above coffee shop - no tablecloths, no black napkins for those customers wearing black, lighting average. The service is poor. After being seated, no one approached our table for quite some time. Finally a busboy asked if we would like to see a menu. We requested a black napkin from three different people. None of them returned to say they did not have black napkins. During the meal the server did stop by occasionally to check on us. When we no longer had any wine nor food on our table, we again sat for quite some time waiting for a bill. The poor service may discourage us from returning.Special Features:
- The meat was overly saltedwwwwVIPDined on 9/20/2008The meat was overly salted or MSG. We both suffered sever cramps and intestinal disorder from the food.Special Features:
- Deseo has a lovely ambienceOccasionalDinerDined on 9/18/2008Deseo has a lovely ambience and very attentive service. The prices are "Scottsdale" so read that as high. The vegetable side dish was overcooked, but the entrees were cooked right...the lamb was a bit too cold, indicating it was not picked up immediately for service. However, the lamb was quite tasty, and the sea bass was nice as well. The portions for the price were undersized, a negative. Would we go back again....probably not. The wines were overpriced, the portions were undersized, and since Scottsdale has so very many good restaurants, this one will not be beckoning us to return.
- We thoroughly enjoyed Deseo.OpenTable Diner Since 2007Dined on 9/18/2008We thoroughly enjoyed Deseo. We had exceptional service and the food was outstanding. We will definitley be back upon our next trip to the area.Special Features:
- Loved it! They surprised usLuv2EatOutDined on 9/7/2008Loved it! They surprised us with a delectable desert when they learned it was our anniversary. The churrasco was to die for. Pricey, yes, but for a special occasion, it was a great experience.Special Features:
- We had heard good things aboutOpenTable Diner Since 2005Dined on 7/12/2008We had heard good things about Deseo and were happy that they are all true. We arrived early to have a drink at the bar. The service was a bit slow but they more than compensated by not charging us for the drinks! The food is excellent. We shared a cevechi trio then a goat cheese empanada for appetizers. Our main courses were a tuna special and the lamb. Try the side of chic peas and spinach - it's yummy. The chocolate cigar desert was the perfect ending to a great meal. We'll be back.Special Features:
- Loved it! The waitress wasOpenTable Diner Since 2006Dined on 7/10/2008Loved it! The waitress was very helpful in describing the different foods available.Special Features:
- We were pretty dissapointedOpenTable Diner Since 2006Dined on 7/4/2008We were pretty dissapointed with the food and service. Millionaire tacos were very good but everything else was just so so. I would not return for a second visit.
- Deseo cuisine is cuban andOpenTable Diner Since 2008Dined on 6/27/2008Deseo cuisine is cuban and south american influenced. We thought the food was amazing. The dishes are very creative and the appetizers and deserts were extraordinary. We would highly recommend trying this restaurant to anyone.Special Features:
- I made a reservation for 12OpenTable Diner Since 2012Dined on 6/22/2008I made a reservation for 12 people. It was a VIP group and I checked on it the prior day. When I arrived at the restaurant with my guests, we were told that the large table in the middle was taken by someone else and they wanted to seat us at two round tables. This was a VIP group for the NIB conference which included Presidential appointees, and we were bumped by a group of conference attendees. I expect that when I make a reservation for 12 people to get one table and should be notified if that cannot be accommodates. Needless to say, it was very embarassing and the staff was not able to resolve it satisfactorily.
- I had been to Deseo sevenOpenTable Diner Since 2008Dined on 6/21/2008I had been to Deseo seven times since it opened. I hadn't been for over a year and we were very surprised with our last experience. I made a reservation for 7:30. When we got there, one of the hostesses spoke so softly we couldn't understand what she was saying. She led us into the restaurant and directly to the bar. We thought that was very strange, since no one was sitting at the bar. I asked if we could have a table, since the restaurant was about half full. She didn't say a word and just had this creepy smile on here face and showed us to a table nearby. Then she said something in a very soft voice, all the while keeping this strange smile on her face. We thought we had drifted into the Twilight Zone...a very uncomfortable experience.Special Features:
- We've been to Deseo severalOpenTable Diner Since 2008Dined on 6/21/2008We've been to Deseo several times now, and we are never disappointed with the food or service. The mojitos are fantastic. There are so many great things on the menu, it's hard to choose, and we often end up ordering too much. We said this time we would just order a few things, but then we get there and everything looks so good that it happened again. We ended up taking the crab fried rice and the wild mushroom side dishes home, and they were great left over. We love this place and look forward to going back.Special Features:
- My wife and I went to DeseoopentablevipVIPDined on 6/13/2008My wife and I went to Deseo for our anniversary dinner. We happened to be attending a conference at the Kierland Resort and thought we should try Deseo, since we were there. The food (we had a tasting menu) was very good. We have a second home in Charleston, SC, which allows us access to some of the best restaurants in the world on a regular basis, and the food at Deseo was sophisticated and flavorful. Our only mild criticism of the tasting menu was that it was nearly all protein, with the exception of the dessert and a salad course. Perhaps this is the expectation of the restaurant's regulars, but we would have preferred more vegetables in the mix. This is a quibble, though. The food and overall experience are great.Special Features:
- We've eaten here several times,OpenTable Diner Since 2006Dined on 5/31/2008We've eaten here several times, but this time the food was not as good as previous times. They did give us a special dessert for our anniversary and the service was excellent. We do enjoy the appetizers at the bar although they did not mention that they changed their policy during Westin Unwind time (5:30 PM -7:30PM). The drinks are no longer two for one and their appetizers are no longer half price.Special Features:
- Our waitress Danielle andOpenTable Diner Since 2007VIPDined on 5/29/2008Our waitress Danielle and the bartender Scott were GREAT! All of you made my husband's 40th birthday celebration very special. Thank you!Special Features:
- Food was awesome. Just spicyOpenTable Diner Since 2007Dined on 5/25/2008Food was awesome. Just spicy enough to have a kick without being over the top. Duck entree was the best I have had and, although I generally don't love fish, theirs was amazing. Best of all, try the ceviche. Order a bunch and share, they are incredible. If you are with a small enough group, ask to sit at the counter, where you can overlook the kitchen, talk to the staff and, if you ask nicely (look pathetic enough :-)) , have them give you tastes of what they are preparing.Special Features:
- A very good Latin theme restaurant.Act3VIPDined on 5/24/2008A very good Latin theme restaurant. Not cheap but food is quite good.Special Features:


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Book Description:
A caustic and hilarious love story set in 1990s New York.Bob Fingerman's Beg the Question tells the story of Rob and Sylvia, two twentysomethings navigating the labyrinth of New York City life. Imagine a cross between Seinfeld and Caligula, set in New York, and you'll have an idea of Fingerman's caustic wit. Beg the Question follows Rob & Sylvia's relationship through all of its ups-and-downs, from courtship to marriage, rentals to real estate salesmen, public sex to unwanted pregnancies, and everything in between. Performance art, extended families, the comic book industry and Screw magazine are just a few of the other topics subjected to Fingerman's satirical microscope. Featuring an introduction by Penn Jillette.
Tags: Science-Fiction-Fantasy,


text: 1500 pts What Are Your Fitness Habits? [SURVEY] <Classic Rewards Club Let us know for 1,500 points! Sign in to Participate Category: Q & A Visit our sponsor: Integrative Experience Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! More Ways To Get and Use Points Greg's Flashback Trivia 11/25/2014Greg's Flashback Trivia 11/24/2014Oldiez Person Of Interest – Week of November 24thBeer Break of the Day – Week of November 24thWODZ Listen Live Word Of The Day – Week Of November 24thWeekly Bonus Code Week of November 24th


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The SquadsAtletico de Kolkata Apoula Bete, Basilio Agudo, Subhasish Chowdhury, Arnab Mondal, Biswajit Saha, Denzil Franco, Jose Rey, Kingshuk Debnath, Nallappan Mohanraj, Sylvain Monsoreau, Borja Fernandez, Luis Garcia, Cavin Lobo, Climax Lawrence, Jakub Podany, Jofre ... Deccan Herald, 1 month ago
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FC GOA 1 - 2 ATLÉTICO DE KOLKATA FC Goa: Seda; Debabrata, Gregory, Bengelloun, Narayan; Peter, Pirés (Pinheiro 86'), Santos, Miranda (Narzary 74'), Gabriel and Martins (Ozbey 80'). Atlético de Kolkata: Edel; Denzil (Sanju 22'), Arnab, Josemi, ...Noodls, 1 month ago
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Federal Awards Ahn, Chul, Cleveland Clinic Fdn/NIH, Elucidating a Novel Molecular Biomarker for Castration-Resistant Prostate Cancer, $10,330; Altschuler, Steven (Fellow C. Thorne), NIH, The Role of Kinase Signaling in Intestinal Epithelial ...University of Texas, 2 weeks ago
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The BMW HP4, one of the world's fastest factory motorcycles that packs a peak speed of 300kmph, leads a pack of 11 other superbikes on serious weekend cruises — not on some foreign autobahn but highways in and around Calcutta. Sounds incongruous ...Calcutta Telegraph, 1 month ago
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Environmental Defense
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Oceans Communications Team Intern
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EDF is seeking an Oceans Communications Intern for Winter 2014. Interested applicants should have communications, research and writing skills. Basic… Glassdoor
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EDF Clean Energy Program: Electric utilities are poised to invest up to $2 trillion in infrastructure over the next two decades to modernize our… Glassdoor
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With world attention focused on both the environment and the economy, Environmental Defense Fund (EDF) is where policymakers and business leaders… Glassdoor
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The Office of Chief Scientist is the nexus of science at EDF, ensuring that the natural and social science that is the backbone for all EDF policy… Glassdoor
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Natural gas is an important and growing part of our nation's energy portfolio. It could be a win-win, if--and this is a big "if"--we do it the right… Glassdoor
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Environmental Defense Fund (edf.org: http://edf.org/), a leading international nonprofit organization, creates transformational solutions to the most… Glassdoor
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The internships are ten weeks in duration, and thirty-five hours per week (full-time). We seek students interested in working on cutting edge… Glassdoor
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The Office of Chief Scientist is the nexus of science at EDF, ensuring that the science (natural and social sciences) that is the backbone for all… Glassdoor
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Natural gas is an important and growing part of our nation's energy portfolio. It emits fewer greenhouse gases than coal when combusted and avoids… Glassdoor
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In an open letter to Yahoo CEO Marissa Mayer, the investment management firm Starboard makes its case for the oft-rumored pair-up.
While several charges were dropped, former Anonymous spokesman Barrett Brown pleads guilty to sharing stolen data and targeting a federal agent.
The Boycott Divestment and Sanctions movement is coming out with a smartphone app that can scan products to see if the manufacturer has ties to Israel.
Two years ago this week, authorities arrested a computer programmer, Bassel Khartabil, involved in protests against the Syrian government. There's still no word on when he'll be released.
A handful of profiles and pages on the social network, which have been gathering places for Syrians to discuss their country's civil war, have mysteriously disappeared.
Ai Weiwei creates an elaborate series of installations for display on Alcatraz, even though he's forbidden from traveling outside China and has never been to the notorious prison site.
Some investors are less than pleased with the turnaround plan of Yahoo CEO Marissa Mayer and want AOL CEO Tim Armstrong to consider a merger, says Reuters.
Women, Action & the Media -- one of the groups behind the #FBrape campaign that prompted a policy change from Facebook -- is working with Twitter to improve the social-media service's response to online harassment.
Describing herself as a social activist, public speaker and contributor to Vanity Fair, Lewinsky decides now is the time to enter the fray of immediacy.
Apple's CEO publicly discussed his sexual orientation for the first time in an effort to help anyone "struggling to come to terms with who he or she is."


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"Hey WWE I'm not trying to be rude but the crowd seems to really want Daniel Bryan. Juuuuuuust MAFAKIN Saying!! Geez. Sadly WWE is still run by 'Muscle Marks.' It is what it is folks."
- Shane Helms on backstage politics in WWE
"You're not allowed to get over in WWE unless they want you to. If you do, you can and will be punished. Has happened to many over the years."
- Armando Estrada on backstage politics in WWE
"Toronto deserves Rob Ford, they put him in office. Toronto deserves everything it gets. Up in Calgary we've got a more prestigious mayor [Naheed Nenshi]. I think we've got the best mayor in North America."
Jimmy Hart has managed some of the most well known performers in WWE history, but his very first client in the company was Greg Valentine, who was the Intercontinental Champion at the time. Management would split up the duo shortly after Valentine lost the belt.
Jimmy Hart managed King Kong Bundy at the very first Wrestlemania, but the longtime WWE manager traded him to Bobby Heenan in exchange for Adrian Adonis and the Missing Link soon afterwards.
Booker T, Sheamus, Rey Mysterio, Kaitlyn, Alicia Fox, Mark Henry, Jimmy Hart and Mick Foley are hosting a Wrestlemania 30 part in New Orleans this weekend.
Jerry Lawler and Jimmy Hart were classmates at Memphis Treadwell High School.
Roddy Piper will be doing a Piper's Pit segment with Jimmy Hart at an independent wrestling show in New York this weekend.


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Designer Marika Meyer is in baby overload. In addition to moving her 2-year-old son, Grayson, into his big boy room before Baby No. 2 arrives in December, she has seven clients who are expecting.
None of her clients has chosen to learn the gender of the baby before birth. For Meyer, who is in charge of decorating each nursery, this means no princess murals or race car beds. These days, she said, neutrals are the new pink and blue.
Parents don't want to compromise the home's sophistication just because there are children in it, said Meyer, who lives and works in Bethesda, Md. Keeping the walls neutral allows them to have both.
Meyer suggests soft, pale colors that won't be overwhelming when the room fills with toys and books. Benjamin Moore's Thornton Sage, a mint green with a hint of robin's egg blue, is the color of Grayson's room, which Meyer said looks perfectly serene accented with white trim and green-blue window treatments. Stonington Gray, also by Benjamin Moore, is the top pick for his next room, but Meyer said it could be equally pretty in a girl's room if accented with the Pantone shade Kelly green.
Sonu Mathew, senior interior designer for Benjamin Moore paints, thinks gender-neutral paint choices are part of a larger cultural movement that allows children more creative freedom.
This trend is about equality and appreciating children for who they are rather than sorting them into categories from the get-go, she said. It says a lot about how we're raising our children today.
Mathew, who has three boys, including 9-month-old twins, said guests couldn't guess the gender of her children by walking into their bedrooms. She likes this because historically, color didn't always carry so much weight.
Before World War II, trends in fashion and design pointed to boys wearing pink just as quickly as girls would wear blue, she said. So today, we're going back into that space where things are more level.
Mathew's go-to colors are Sweet Daphne, a muted apple green, Fun 'n' Games, a bright beachy blue, and African Violet, a bold lilac with a touch of red.
Children in particular respond to purple because of its mystical history, Mathews said. For centuries, only royalty could afford purple paint because of its expensive dye. Today, it represents nobility, mystery and magic. (Perhaps that's why it appears so frequently in the Harry Potter books.)
Far more than pink, blue has become a favorite of both girls and boys, said Erika Woelfel, Behr's director of color marketing.
Themes – unicorns, kitties and cowboys – are tired, she said. Parents want paint to last beyond the baby years, so we're seeing a lot of blue, green and wheat.
For a boy's room, Woelfel recommended Behr's Tahoe Blue trimmed with Minted Lemon, a leafy green. For a girl's room, trim it with crisp white.
Yellow is a risk-free, classic color that will last until college for a boy or girl, according to the paint experts.
Newell Turner, editor-in-chief of House Beautiful, said a warm, sandy yellow is the most versatile gender-neutral color there is, because it can be paired with feminine or masculine accessories and even draws a little from nature. His favorite is Pebble Beach by Mythic Paint. Meyer likes Manchester Tan, a beige-yellow from Benjamin Moore's historic collection, and Woelfel suggests Behr's Pale Wheat, which resembles a deep tan, for its longevity and sophistication.
Mathews favors Lemon Sorbet, a bright buttery yellow that is also Benjamin Moore's color of the year for 2013. We're moving away from the deep, saturated colors of the past decade, she said, and toward polished pastels.
More simply, pale yellow is easy. Turner described it as a chameleon color that provides an easy transition into the other rooms of the home, which is ideal for parents whose aim is subtlety.
Yellow is optimistic, energetic and confident, which are all very important words for children, Mathew said. They're also important words for where we're headed in 2013, and I love that I can say that. It's a color of transition and this is a transitional time.


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Monday: vs. Dallas, 7 p.m. (NBA TV, FSOK) — Thunder's five-game home stand begins against Dallas, which is in the midst of playing six of eight on the road in 11 days.
Next five games for the OKC Thunder
Wednesday: vs. Phoenix, 7 p.m. (FSOK) — Suns are making a midseason push and have won four of their last five, including home wins over the Lakers and Clippers.
Friday: vs. Cleveland, 7 p.m. (FSOK) — Rookie of the year front-runner Kyrie Irving visits. Cavs have beaten Dallas, Clippers, Indiana, New York and Boston this season.
Saturday: vs. Charlotte, 7 p.m. (FSOK) — Arguably the worst team in NBA history pays a visit with former Thunder players Byron Mullens and D.J. White in tow.
March 13: vs. Houston, 7 p.m. (FSOK) — Home stand ends with Rockets coming to town. OKC will be looking for payback from a 96-95 loss in Houston on Feb. 15.
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StartUpHire is the place to find PAXIT OPERATIONS MANAGER jobs. Review the list of PAXIT OPERATIONS MANAGER career opportunities to the left. These PAXIT OPERATIONS MANAGER jobs represent some of the most rewarding careers available.
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General Summary: This is a full time position within Remedi SeniorCare reporting directly to the General Manager. The Front End Manager will provide day-to-day guidance and leadership oversight to the front-end staff pharmacists, order entry, medical records technicians, and9/30/2014 BALTIMORE, MD Save This Job


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Ooops! Olympic Torch goes out in Moscow
A lantern containing the Olympic flame arrived in Moscow's Red Square where it was greeted by Russian President Vladimir Putin, before it promptly blew out.
After Mr Putin lit the cauldron, he said the "Olympic flame - symbol of the most important sports competition of this planet, symbol of peace and friendship - has arrived in Russia."
The flame then set out on a ceremonial loop through the Kremlin, with 11 torchbearers participating in a relay.
However, the flame, which was lit a week ago in Greece and flown to Moscow earlier on Sunday, went out.
The glitch occurred when torchbearer, former world swimming champion and record holder Shavarsh Karapetyan, ran through a long passageway leading into the Kremlin, which apparently created a wind tunnel, extinguishing the flame.
A security guard standing along the route, pulled out a lighter and re-lit the torch.
The torch relay will stay in Moscow for the next three days, with hundreds of athletes, cultural figures and others, including Prince Albert II of Monaco, taking part.
The flame will then begin its journey across Russia, travelling from the western exclave of Kaliningrad to the eastern-most point just across the Bering Strait from Alaska, before swinging back through the vast country to Sochi in time for the opening ceremony on February 7th.
For most of the 39,000-mile trip the flame will travel by plane, train, car and even reindeer-sleigh, safely encased inside a lantern.
One of the silver and red torches, unlit, will be carried into space in November for a brief visit to the International Space Station, and this same torch will be used to light the Olympic flame in Sochi.
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i want to put some effect to my screen, when it navigates to other page. When i click a button in the first page it should navigate to second page. i want some effect when navigate to second page, can anyone tell me how to do this?
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check out the fl.transitions package in the ActionScript documentation. there are some ready-made transitions you can use (Fade, Fly, Wipe, etc.) or you can create your own with the Tween class.


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