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1-20 of 79 items from 2014 « Prev | Next »
27 November 2014 6:50 AM, PST | We Got This Covered | See recent We Got This Covered news »
Ever since it was taken offline back in 2012, there have been murmurings that Metal Gear Online – the spin-off multiplayer component within Hideo Kojima's seminal stealth series — would make a reappearance on new hardware.
Fast forward to 2014 and it turns out series creator Kojima is indeed ready to reintroduce the ill-fated tactical shooter, which will have its "world premiere" during next week's The Game Awards in Las Vegas, according to longtime host Geoff Keighley.
Next Friday night I'm honored @HIDEO_KOJIMA_EN will join us at @thegameawards to world premiere Metal Gear Online. pic.twitter.com/rT6sLDfdxb
— Geoff Keighley (@geoffkeighley) November 27, 2014
First appearing within Metal Gear Solid 3: Subsistence on the PlayStation 2, the multiplayer section is perhaps best known for Metal Gear Solid 4: Guns of the Patriots. Alas, it never truly gained traction in the way that Kojima would have liked, which forced the studio to »
- Michael Briers
27 November 2014 2:44 AM, PST | Obsessed with Film | See recent Obsessed with Film news »
Unless you've been living under a rock for the last twenty years or so, you'll have heard of the legendary Metal Gear Solid series. Undoubtedly, someone you know will have gushed to you about its greatness for hours on end while you sit there and struggle to understand everything coming out of their mouths – that's the Mgs effect.
It's definitely a series that needs to be played; words simply cannot do it justice. Not only does it create intense, atmospheric stealth gameplay – it also has a sprawling epic story which ties together a number of plot threads at once with lengthy, movie-like cutscenes creating memorable moments throughout.
Intriguingly, Metal Gear isn't bound by realism. Instead, somewhere in development, creator Hideo Kojima decided to forego convention and simply allowed himself to make Metal Gear as bonkers as possible.
As a result, it doesn't always »
- Sam Coleman
30 October 2014 3:07 PM, PDT | We Got This Covered | See recent We Got This Covered news »
At this year's San Diego Comic-Con, the world was transfixed by Marvel's typically-grandiose Hall H presentation. However, they weren't the only studio on hand to deliver bombshells to the film industry in attendance. During their spot in the limelight, Legendary Studios revealed plans for a King Kong prequel titled Skull Island.
While news has been on the slow side, there are a few elements firmly in place. From the offset, Godzilla scribe Max Borenstein was brought on board to work on the script, which seemed to have satisfied the studio as they granted the pic a 2016 release date. Moving on a few months and news landed that Loki himself, Tom Hiddleston, had signed on to take the leading role under the direction of Jordan Vogt-Roberts.
Today's news, which Deadline broke earlier, now reveals that Borenstein is off the project as he's busy penning the sequel to Godzilla. »
- Gem Seddon
24 October 2014 1:43 PM, PDT | Blogomatic3000 | See recent Blogomatic3000 news »
The Golden Joystick Awards today rewarded the best of the best in international gaming. With over nine million votes cast, the Golden Joysticks once again proved, in its 32nd year, why it is the biggest award show in the world of video gaming.
Dark Souls II was awarded the most prestigious gong of the afternoon – Game of the Year, in association with Green Man Gaming. Following on from Demon's Souls and Dark Souls, this is the third game in this hugely acclaimed series. An action RPG (role-player game), Dark Souls II was the resounding winner as voted for by the worlds gamers.
Lifetime Achievement recipient, Hideo Kojima is revered as one of the most influential and important people in the world of gaming. He has worked in the industry for almost 30 years and without him gaming as we know it would be a unrecognisable. Creator, director and writer of »
- Phil Wheat
2 October 2014 8:30 AM, PDT | Obsessed with Film | See recent Obsessed with Film news »
Selling a video game to players is an art, a feat of marketing and PR that encompasses so many factors and can go so, so wrong at so many points. As such, developers have often avoided the fair, simple option of releasing an honest trailer and letting the public make up their own minds: instead they've flat-out lied to consumers in an attempt to shift units, and naturally, their approach has been a rousing, disgusting success.
There's marketing a video game and then there's intentionally deceiving the player base, which for the most part is what happened in these 13 cases of video games sold to us under one impression and delivering something else that didn't quite measure up. Several of these games are, in fact, pretty good, but they either didn't live up to the hype or simply weren't what fans paid their hard-earned money for, »
- Jack Pooley
26 September 2014 5:45 AM, PDT | Flickeringmyth | See recent Flickeringmyth news »
This years Tokyo Game Show kicked off last week and in attendance was Kojima Productions, Hideo Kojima and his team to show off a brand new trailer for Metal Gear Solid V. The Gameplay trailer and entire conversation on stage was entirely in Japanese and had many western fans wonder what exactly was being discussed as the stunning gameplay trailer was shown.
However, fans outside of Japan can now see a full English version of the gameplay trailer complete with voice over as Punished Snake makes his was through a mountainous jungle terrain akin to that seen in the original MGS3: Snake Eater only with much more up to date and stunning visuals shown off through Kojima's new Fox Engine, which was also demoed at Tgs and plans to be leased to other studios so they to can build their games with the powerful engine, an example which »
- Gary Collinson
19 September 2014 8:30 PM, PDT | Movies.com | See recent Movies.com news »
When you talk about cross-media collaboration dream teams, it's hard to get more impressive than Guillermo del Toro and Hideo Kojima. Gdt is the cinematic visionary who brought us films like Pacific Rim and The Devil's Backbone. Kojima is video game development's biggest rock star, the guy responsible for Metal Gear Solid. What happens when these two guys get together to make something? Silent Hills happens. The latest entry in the classic survival horror video game series will feature Kojima and del Toro working together to scare the bejesus out of you – and if this new footage from the Tokyo Game Show is any indication, the dynamic duo is on the right track. We don't know a whole lot about the game at this point, only that it features The Walking...
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- Mike Bracken
18 September 2014 3:42 PM, PDT | EW.com - PopWatch | See recent EW.com - PopWatch news »
Coming out of last month's Gamescom, a small horror game called P.T., or The Playable Teaser, stole the spotlight. Downloadable for free on the PlayStation 4, the game came with virtually no warning or explanation. Instead, it let players explore—and be horrified by—the game for themselves.
P.T. initially presents itself as a simple affair, set in the hallway of an average-looking house. Players start at one end and walk through the hall to a door that seemingly leads to a garage. But that door instead opens back into the hallway. In each subsequent loop, the hallway changes, »
- Jonathon Dornbush
16 September 2014 11:23 PM, PDT | Den of Geek | See recent Den of Geek news »
The King Kong origin story adds Tom Hiddleston to its cast, and finds a director...
One of the big upcoming projects on the slate of Legendary is its King Kong origin story, Skull Island. Announced at San Diego Comic-Con earlier this year, the film is heading to cinemas in November 2016, with Max Borenstein penning the original screenplay for the film.
Now we learn of a couple of key new personnel additions. In front of the camera, Skull Island has lured in Tom Hiddleston to play the lead (having just finished work on Ben Wheatley's adaptation of J G Ballard's High-Rise). It's busy times for Hiddleston, as he's also set to play Hank Williams in the biopic I Saw The Light.
Meanwhile, directing Skull Island will be Jordan Vogt-Roberts. He helmed the terrific The Kings Of Summer, and is also attached to direct Metal Gear Solid for Sony. We're assuming »
- simonbrew
16 September 2014 1:24 PM, PDT | DailyDead | See recent DailyDead news »
Marvel fans who can't get enough of the demigod Loki may be drawn to the massive monster franchise Legendary is cooking up, as it's just been announced that Tom Hiddleston will play the lead role in the upcoming King Kong origins movie, Skull Island. A new director has also been attached to the film that will explore the seemingly prehistoric island teeming with colossal creatures.
Legendary announced today that Jordan Vogt-Roberts will direct Skull Island off a screenplay by Godzilla scribe Max Borenstein. Skull Island was revealed at this year's San Diego Comic-Con during a surprising teaser video that concluded with an amped-up King Kong. In late July we reported that Joe Cornish (Attack the Block) had been offered the director's chair for the project, but now it is Vogt-Roberts (The Kings of Summer) who will helm the large-scale adventure.
Tom Hiddleston (Only Lovers Left Alive »
- Derek Anderson
16 September 2014 12:09 PM, PDT | SoundOnSight | See recent SoundOnSight news »
Skull Island as seen in the 1933 original
After a surprise announcement at this year's Comic-Con, Legendary Pictures has announced a director and leading actor for the King Kong prequel, Skull Island. The film, set to be released in November 2016, will be directed by The Kings of Summer director Jordan Vogt-Roberts. The director recently directed several episodes of FX's dark romantic comedy You're the Worst and is attached to direct the film adaptation of Metal Gear Solid. The film will star Thor and The Avenger's Tom Hiddleston, who recently starred in Only Lovers Left Alive and will appear in next year's Guillermo del Toro horror film Crimson Peak, which will also be produced by Legendary.
With a screenplay by Godzilla scribe Max Borenstein, the film aims to delve deeper into the mysterious and dangerous island. Skull Island continues Legendary's streak of giant monster movies, as »
- Max Molinaro
16 September 2014 12:09 PM, PDT | Dark Horizons | See recent Dark Horizons news »
Loki himself, "Thor" star Tom Hiddleston, has joined the cast of the King Kong origin movie "Skull Island" for Legendary Pictures.
Hiddleston will reportedly play the lead role in the project, though no further details about his character are available at this point.
At the same time, "The Kings of Summer" director Jordan Vogt-Roberts is confirmed to be directing the film which will deal with the many monsters occupying the mysterious, remote and harsh Skull Island.
Vogt-Roberts, who is also slated to direct the upcoming film based on the "Metal Gear Solid" franchise, confirmed his recruitment via Twitter.
The project, which was announced at this year's Comic Con, is currently targeting a late 2016 release.
Source: Heat Vision »
- Garth Franklin
16 September 2014 10:21 AM, PDT | Flickeringmyth | See recent Flickeringmyth news »
Legendary Pictures announced today that Thor: The Dark World and Only Lovers Left Alive star Tom Hiddleston is in talks to star in the new King Kong film, Skull Island, with The Kings of Summer and You're the Worst director Jordan Vogt-Roberts at the helm.
Unfortunately we still don't know much about the project, though it will explore the titular island that King Kong and various other mysterious and monstrous creatures call home. Previous reports suggested that Attack the Block helmer Joe Cornish was on the studio's mind for the directing job, but they must have found something special in Vogt-Roberts.
This is not the only high-profile project on Vogt-Roberts and Hiddleston's plates, however. Vogt-Roberts is already signed on to direct Metal Gear Solid for Sony, though that project will likely get pushed aside for now. Hiddleston, on the other hand, has a few upcoming films on his slate, »
- James Garcia
16 September 2014 10:03 AM, PDT | We Got This Covered | See recent We Got This Covered news »
At San Diego Comic-Con this past summer, Legendary Pictures made the surprise announcement that a new King Kong movie was in the works. Titled Skull Island, the film will delve into the location of the iconic giant gorilla's origin and will hit theaters on November 4th, 2016.
At the time, no other information about Skull Island - including plot details and the creative team that would bring it to life – were given. Legendary remedied that this morning though by announcing that fan-favorite actor Tom Hiddleston (Thor: The Dark World, Only Lovers Left Alive) is in talks to star in the action flick, with Jordan Vogt-Roberts (The Kings of Summer, You're the Worst) in the director's chair.
Both Vogt-Roberts and Hiddleston have a lot on their plates right now, as the former is also attached to Sony's Metal Gear Solid adaptation, and the latter is in contention for »
- James Garcia
16 September 2014 10:00 AM, PDT | Collider.com | See recent Collider.com news »
When Legendary Pictures unveiled their plans for Skull Island at Comic-Con in July everyone was caught off guard. There was a release date for this King Kong reboot, but not much else besides a teaser trailer. Now we know a lot more. While early reports rumored Attack the Block director Joe Cornish to be in the mix to helm the picture, those duties will now fall to Jordan Vogt-Roberts, who previously directed The Kings of Summer. The film also now has an über-charismatic star in Tom Hiddleston, who absolutely killed it earlier this year in Only Lovers Left Alive. The film will apparently take place almost entirely on the island. Godzilla scribe Max Borenstein has been confirmed to write the script. Skull Island opens on November 4th, 2016. Hit the jump for more. Here's the official press release: Legendary announced its plans to make a feature film based on the cinematic »
- Evan Dickson
16 September 2014 9:55 AM, PDT | MovieWeb | See recent MovieWeb news »
Announced at Comic-Con 2014, Legendary has now secured both a lead actor and a director for it's King Kong origin movie Skull Island.
Tom Hiddleston, who has gone onto gain worldwide fame playing Loki in Thor and Marvel's The Avengers, will take the lead in Skull Island. There are no further details about his character at this time.
Jordan Vogt-Roberts, who directed last summer's sleeper hit The Kings of Summer, is taking the reins on this jungle adventure which will delve into the many monsters occupying Skull Island. The director is behind the upcoming Metal Gear Solid movie for Sony, and helmed the pilot episode of FX's You're the Worst.
He announced himself as director with this tweet:
Honored to join the @Legendary family. Brace for Skull Island!! pic.twitter.com/wufi6ejNwE
— Jordan Vogt-Roberts (@VogtRoberts) September 16, 2014
Skull Island will follow King Kong through his early years, and will not leave this sanctuary, »
- MovieWeb
16 September 2014 9:39 AM, PDT | HeyUGuys.co.uk | See recent HeyUGuys news »
At this year's Comic-Con, Legendary Pictures confirmed that along with Godzilla 2 they were developing a King Kong origin story called Skull Island. No additional details were revealed, though we have since learned that Godzilla scribe Max Borenstein would be penning the screenplay for this monster movie.
That has now been confirmed via press release today as the studio have announced that Jordan Vogt-Roberts is attached to direct Skull Island. He's best known for popular Sundance film The Kings of Summer, but he's also attached to Sony's big screen adaptation of the Metal Gear Solid video game franchise.
Skull Island is set to be released on November 4th, 2016 and a brief (but rather vague) description of the film was included in the announcement. "Previous works have touched on the island, but staying on and exploring this mysterious and dangerous place offers Legendary the opportunity to take audiences »
- Josh Wilding
16 September 2014 9:29 AM, PDT | Deadline New York | See recent Deadline New York news »
Breaking: Legendary Pictures shocked the Comic-Con crowd with a teaser for the King Kong origin film Skull Island. They've set Jordan Vogt-Roberts to helm, and Loki himself, Tom Hiddleston, to star in the Max Borenstein-scripted pic. Previous works have touched on the island, but staying on and exploring this mysterious and dangerous place offers Legendary the opportunity to take audiences deeper inside this rich world, which was the most electrifying parts of Peter Jackson's King Kong done for Universal several years ago. Universal Pictures will release on November 4, 2016.
Vogt-Roberts directed and executive produced the Sundance darling The Kings Of Summer and the FX pilot and subsequent episodes of You're The Worst. He's directing Metal Gear Solid for Sony. Hiddleston wows the Comic-Con crowd every time he comes, so this is fanboy catnip right here. UTA, 3 Arts Entertainment and attorneys Alan Wertheimer and Andy Galker rep the helmer, »
- Mike Fleming Jr
11 September 2014 9:22 AM, PDT | We Got This Covered | See recent We Got This Covered news »
Hideo Kojima is at it once more, dear friends. After his horror-infused stint trolled the industry in the wake of Gamescom — while also introducing us to the Norman Reedus-led Silent Hills, of course — the esteemed director has published a string of enticing Tweets in regards to Metal Gear Solid V: The Phantom Pain.
Before debuting an all-new gameplay clip that features controversial mute sniper, Quiet, Kojima Tweeted a single image that reads 'Metal Gear Solid Collection 2014', hinting that a brand new collection could be on its way to current-gen consoles and maybe, just maybe, PC platforms as well.
Reading the script for Tgs stage show. pic.twitter.com/YcUdwDmia3
— HIDEO_KOJIMA (@HIDEO_KOJIMA_EN) September 11, 2014
Of course, The Phantom Pain itself is en route to PC — via a tongue-in-cheek cardboard box announcement — so it's logical that Kojima would bring the existing franchise to Steam as well in the »
- Michael Briers
8 September 2014 4:27 AM, PDT | Obsessed with Film | See recent Obsessed with Film news »
When it comes to plot twists in gaming, there may not be a more famous series than Hideo Kojima's Metal Gear series. While it began life on the MSX2 home computer in Japan, during an era when storytelling in the medium was limited, Kojima's love of film broke through and allowed him to tell a story that had some real depth to it. It was filled with intrigue, mystery and shocking revelations.
In its twenty-seven years of existence, the Metal Gear series has been swerving gamers with all sorts of insane plot twists and revelations about their favorite characters. From the haunting reveal of Naomi Hunter's true lineage, all the way to the shocking return of Big Boss at the end of Metal Gear Solid 4, Kojima is a master of the craft.
Plot twists on the level that Metal Gear presents them are a difficult thing to pull off, »
- Matthew Fisher
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Nikon DSB-N1 Digiscoping Bracket
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subset: commoncrawl


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Bio: Award winning saxophonist, composer and producer Karel Ruzicka Jr. has a way to captivate the audience in practically any musical context. It was already evident back in 1992 when his group "The Four" was awarded the first prize at the International Jazz Festival in Karlovy Vary, Czech Republic ... See Full BioMore Info
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Something funny happened the other day. The mother of my kids' friend brought my daughter back home after a play date, and asked if she could speak to me privately for a second. At these words, I felt a chill, because my daughter is something of a loose cannon. She is five years old, and has silky, honey-colored hair, large doe eyes, dimpled cheeks like a rose in bloom—and the mind of an unhinged baboon. Not to mention that she idolizes her brothers, ages 7 and 9, and strives mightily to keep up with their sophisticated culture of violence and poop jokes.
So I was worried. But the mother was concerned about something different: It seems that my daughter somehow found out that her...READ MORE


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PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation
- Dong I. Lee,
- Susan Vahebi,
- Carlo Gabriele Tocchetti,
- Lili A. Barouch,
- R. John Solaro,
- Eiki Takimoto,
- David A. Kass
- … show all 7 hide
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Phosphodiesterase type 5A (PDE5A) inhibitors acutely suppress beta-adrenergic receptor (β-AR) stimulation in left ventricular myocytes and hearts. This modulation requires cyclic GMP synthesis via nitric oxide synthase (NOS)-NO stimulation, but upstream and downstream mechanisms remain un-defined. To determine this, adult cardiac myocytes from genetically engineered mice and controls were studied by video microscopy to assess sarcomere shortening (SS) and fura2-AM fluorescence to measure calcium transients (CaT). Enhanced SS from isoproterenol (ISO, 10 nM) was suppressed ≥50% by the PDE5A inhibitor sildenafil (SIL, 1 μM), without altering CaT. This regulation was unaltered despite co-inhibition of either the cGMP-stimulated cAMP-esterase PDE2 (Bay 60-7550), or cGMP-inhibited cAMP-esterase PDE3 (cilostamide). Thus, the SIL response could not be ascribed to cGMP interaction with alternative PDEs. However, genetic deletion (or pharmacologic blockade) of β3-ARs, which couple to NOS signaling, fully prevented SIL modulation of ISO-stimulated SS. Importantly, both PDE5A protein expression and activity were similar in β3-AR knockout (β3-AR−/−) myocytes as in controls. Downstream, cGMP stimulates protein kinase G (PKG), and we found contractile modulation by SIL required PKG activation and enhanced TnI phosphorylation at S23, S24. Myocytes expressing the slow skeletal TnI isoform which lacks these sites displayed no modulation of ISO responses by SIL. Non-equilibrium isoelectric focusing gel electrophoresis showed SIL increased TnI phosphorylation above that from concomitant ISO in control but not β3-AR−/− myocytes. These data support a cascade involving β3-AR stimulation, and subsequent PKG-dependent TnI S23, S24 phosphorylation as primary factors underlying the capacity of acute PDE5A inhibition to blunt myocardial β-adrenergic stimulation.
- Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA (2005) Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans. Circulation 112:2642–2649 CrossRef
- Bremer YA, Salloum F, Ockaili R, Chou E, Moskowitz WB, Kukreja RC (2005) Sildenafil citrate (viagra) induces cardioprotective effects after ischemia/reperfusion injury in infant rabbits. Pediatr Res 57:22–27 CrossRef
- Brixius K, Bloch W, Ziskoven C, Bolck B, Napp A, Pott C, Steinritz D, Jiminez M, Addicks K, Giacobino JP, Schwinger RH (2006) Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium. Can J Physiol Pharmacol 84:1051–1060 CrossRef
- Castro LR, Verde I, Cooper DM, Fischmeister R (2006) Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes. Circulation 113:2221–2228 CrossRef
- Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C (2005) Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation 111:2469–2476 CrossRef
- Dostmann WR, Taylor MS, Nickl CK, Brayden JE, Frank R, Tegge WJ (2000) Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation. Proc Natl Acad Sci USA 97:14772–14777 CrossRef
- Fischmeister R, Castro LR, Abi-Gerges A, Rochais F, Jurevicius J, Leroy J, Vandecasteele G (2006) Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. Circ Res 99:816–828 CrossRef
- Fisher PW, Salloum F, Das A, Hyder H, Kukreja RC (2005) Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation 111:1601–1610 CrossRef
- Gauthier C, Leblais V, Kobzik L, Trochu JN, Khandoudi N, Bril A, Balligand JL, Le Marec H (1998) The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest 102:1377–1384 CrossRef
- Gauthier C, Seze-Goismier C, Rozec B (2007) Beta 3-adrenoceptors in the cardiovascular system. Clin Hemorheol Microcirc 37:193–204
- Kobayashi T, Jin L, de Tombe PP (2008) Cardiac thin filament regulation. Pflugers Arch 457:37–46 CrossRef
- Kobayashi T, Yang X, Walker LA, Van Breemen RB, Solaro RJ (2005) A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol 38:213–218 CrossRef
- Kooij V, Boontje N, Zaremba R, Jaquet K, Dos RC, Stienen GJ, van der Velden (2009) Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium. Basic Res Cardiol. doi:10.1007/s00395-009-0053-z
- Layland J, Li JM, Shah AM (2002) Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes. J Physiol 540:457–467 CrossRef
- Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechene P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G (2008) Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circ Res 102:1091–1100 CrossRef
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- Massion PB, Dessy C, Desjardins F, Pelat M, Havaux X, Belge C, Moulin P, Guiot Y, Feron O, Janssens S, Balligand JL (2004) Cardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction. Circulation 110:2666–2672 CrossRef
- Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA (2009) Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol 47:576–585 CrossRef
- Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M (2006) Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res 98:226–234 CrossRef
- Moniotte S, Kobzik L, Feron O, Trochu JN, Gauthier C, Balligand JL (2001) Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Circulation 103:1649–1655
- Nagayama T, Hsu S, Zhang M, Koitabashi N, Bedja D, Gabrielson K, Takimoto E, Kass DA (2009) Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy due to pressure-overload. J Am Coll Cardiol 53:207–215 CrossRef
- Nagayama T, Zhang M, Hsu S, Takimoto E, Kass DA (2008) Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil. J Pharmacol Exp Ther 326:380–387 CrossRef
- Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED (2007) Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 116:238–248 CrossRef
- Piggott LA, Hassell KA, Berkova Z, Morris AP, Silberbach M, Rich TC (2006) Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments. J Gen Physiol 128:3–14 CrossRef
- Pokreisz P, Vandenwijngaert S, Bito V, Van den BA, Lenaerts I, Busch C, Marsboom G, Gheysens O, Vermeersch P, Biesmans L, Liu X, Gillijns H, Pellens M, Van Lommel A, Buys E, Schoonjans L, Vanhaecke J, Verbeken E, Sipido K, Herijgers P, Bloch KD, Janssens SP (2009) Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice. Circulation 119:408–416
- Recchia FA, McConnell PI, Bernstein RD, Vogel TR, Xu X, Hintze TH (1998) Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog. Circ Res 83:969–979
- Rozec B, Gauthier C (2006) beta3-adrenoceptors in the cardiovascular system: putative roles in human pathologies. Pharmacol Ther 111:652–673 CrossRef
- Salloum FN, Abbate A, Das A, Houser JE, Mudrick CA, Qureshi I, Hoke NN, Roy SK, Brown WR, Prabhakar S (2008) Kukreja RC (2008) Sildenafil (Viagra) Attenuates Ischemic Cardiomyopathy and Improves Left VentricularFunction in Mice. Am J Physiol Heart Circ Physiol 294:H1398–H1406 CrossRef
- Satoh S, Makino N (2001) Intracellular mechanisms of cGMP-mediated regulation of myocardial contraction. Basic Res Cardiol 96:652–658 CrossRef
- Senzaki H, Smith CJ, Juang GJ, Isoda T, Mayer SP, Ohler A, Paolocci N, Tomaselli GF, Hare JM, Kass DA (2001) Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. FASEB J 15:1718–1726 CrossRef
- Shah AM, Spurgeon HA, Sollott SJ, Talo A, Lakatta EG (1994) 8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes. Circ Res 74:970–978
- Surapisitchat J, Jeon KI, Yan C, Beavo JA (2007) Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. Circ Res 101:811–818 CrossRef
- Takimoto E, Belardi D, Tocchetti CG, Vahebi S, Cormaci G, Ketner EA, Moens AL, Champion HC, Kass DA (2007) Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5. Circulation 115:2159–2167 CrossRef
- Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA (2005) cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. Circ Res 96:100–109 CrossRef
- Takimoto E, Champion HC, Li M, Belardi D, Ren S, Rodriguez ER, Bedja D, Gabrielson KL, Wang Y, Kass DA (2005) Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med 11:214–222 CrossRef
- Tsai EJ, Kass DA (2009) Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. Pharmacol Ther 122:216–238 CrossRef
- Varghese P, Harrison RW, Lofthouse RA, Georgakopoulos D, Berkowitz DE, Hare JM (2000) beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. J Clin Invest 106:697–703 CrossRef
- Vila-Petroff MG, Younes A, Egan J, Lakatta EG, Sollott SJ (1999) Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes. Circ Res 84:1020–1031
- Wang H, Kohr MJ, Traynham CJ, Ziolo MT (2009) Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. J Mol Cell Cardiol 47:304–314 CrossRef
- Wattanapermpool J, Guo X, Solaro RJ (1995) The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar activity only when it is phosphorylated. J Mol Cell Cardiol 27:1383–1391 CrossRef
- Wolska BM, Vijayan K, Arteaga GM, Konhilas JP, Phillips RM, Kim R, Naya T, Leiden JM, Martin AF, de Tombe PP, Solaro RJ (2001) Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions. J Physiol 536:863–870 CrossRef
- Wu AY, Tang XB, Martinez SE, Ikeda K, Beavo JA (2004) Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A. J Biol Chem 279:37928–37938 CrossRef
- Yang L, Liu G, Zakharov SI, Bellinger AM, Mongillo M, Marx SO (2007) Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits. Circ Res 101:465–474 CrossRef
- Yasuda S, Coutu P, Sadayappan S, Robbins J, Metzger JM (2007) Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circ Res 101:377–386 CrossRef
- Zaccolo M (2006) Phosphodiesterases and compartmentalized cAMP signalling in the heart. Eur J Cell Biol 85:693–697 CrossRef
- Title
- PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation
- Journal
Basic Research in Cardiology
Volume 105, Issue 3 , pp 337-347
- Cover Date
- 2010-05-01
- 10.1007/s00395-010-0084-5
- Print ISSN
- 0300-8428
- Online ISSN
- 1435-1803
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Phosphodiesterase
- Sildenafil
- Myocytes
- Adrenergic
- Contractility
- Calcium
- Troponin I
- Beta-3 adrenergic receptor
- Protein kinase G
- Cyclic GMP
- Industry Sectors
- Authors
- Dong I. Lee (1)
- Susan Vahebi (1)
- Carlo Gabriele Tocchetti (1)
- Lili A. Barouch (1)
- R. John Solaro (2)
- Eiki Takimoto (1)
- David A. Kass (1)
- Author Affiliations
- 1. Ross 858, Division of Cardiology, Department of Medicine, Johns Hopkins University Medical Institutions, 720 Rutland Ave, Baltimore, MD, 21205, USA
- 2. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA


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10 Steps to Pick the Right Doctor
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In our Waste Watch segment, do county employees get a better match on their retirement plan than most of those footing the bill for it?
A KFDM viewer writes quote: "A Jefferson County employee recently told me that the County was matching her 401k plan payments 250%. How can we afford this? No wonder our taxes are always going up.The taxpayers should be informed."
A check of the Jefferson County retirement plan actually shows a match of 200-percent... meaning for every one dollar the employee contributes to the plan, the county puts in two dollars.
All employees must contribute 7% of their pay and cannot elect to contribute more. In defense of the plan a county worker wrote KFDM said they often do not get regular pay raises like workers in the private sector. The match was established in 2007.
For 2013, Jefferson County has budgeted almost $ 9 million for the county's match or about $8700 dollars per employee.
A check of other counties of similar size shows the match is not unusual.
Mclennan and Webb counties match even more.. 250-percent. Smith County matches 100 percent.
Jefferson County 200%
Mclennan County 250%
Webb County 250%
Lubbock County 200%
Smith County 100%
According to the Bureau of Labor Statistics, more than half of all employees in the private sector get only a 50% match on their company plan.
If you've got a question or a tip about government spending email us at Waste Watch at KFDM dot com.
Jefferson County workers get 200% retirement match
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Junior Research Fellowships
Marie Curie Actions Co-fund. More
Marie Curie Actions. More
European Research Council. More
'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Researchers. More
Add to My Favorites
Please note that the job is no longer active!
*Junior Research Fellowships*
Imperial College London is delighted to invite applications for its Junior Research Fellowship scheme, to give outstanding early-career researchers an opportunity to develop independent research programmes. In 2013, we will be awarding up to 20 Fellowships. Each one offers up to three years funding (stipend in the range £31,300 to £37,800 and up to £10,000 per annum research expenses). Fellowships are designed to provide freedom to focus on research: there are no...
Please note that some fellowship programmes might not be available in English. This depends on publication policy applied by Naturejobs. Thank you for your understanding!
Research Fields
OtherThis fellowship comes from a partnership between EURAXESS and Naturejobs. Get more details!
|Eligible destination country/ies for fellows
|United Kingdom
|Eligibility of fellows: country/ies of residence
|Eligibility of fellows: nationality/ies
|Website of Fellowship Programme
|Career Stage
|Early stage researcher or 0-4 yrs (Post graduate), Experienced researcher or 4-10 yrs (Post-Doc), More Experienced researcher or >10 yrs (Senior)
|Research Profile
|Not defined
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I am a Businessman from Mumbai. I have always been a follower of AOL and Guruji. Now, the miracle which I am going to take you through happened when I wasn't exactly an ardent devotee. This miracle caused a complete U – Turn in my life. Here is what happened…. ... Read More »
Don't Worry! – Sri Sri is around
November 23, 2014


text:
Narrow your search
Phone not handy? Just type your reminder into a Google search box. Here's how.
The reviews site rolls out a new tool that lets customers book restaurant reservations directly from its website on mobile or desktop.
One of the world's fastest-growing Internet companies finally files its US initial public offering, seeking about $20 billion, reports speculate.
You can't stop Google from scanning your inbox or serving you ads, but you can opt out of receiving personalized ads in Gmail. And you can eliminate one prominent ad banner altogether.
On Tuesday, Microsoft will make Windows 8.1 Update available. To continue to get patches, 8.1 users need to move to it soon.
With one of the planet's biggest technology parties just days away, CNET briefs you on all the gadgetry that CES 2014 could bring.
No one wants to meet a four-digit phone bill. Whether it's calls or data that sneak up on you, here are just a few ways to make sure you never have to find one in your future.
Tuesday's "we still have a lot to cover" event should bring revamped iPads, new Mac computers, and a passel of new software unto the world.
Organize your life with one of these incredibly useful Android applications for keeping track of notes, tasks, and to-do lists.
Want to get reminders to answer an e-mail later without adding it to your calendar? Need to make sure someone follows up with your e-mail questions? This app can help you streamline the process between your desktop and Android device.


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All HCPL branches will close on Wednesday, November 26 at 5 PM and will be closed Thursday, November 27-Sunday, November 30. We will reopen on Monday, December 1 for regular hours.
Lone Star College - Cy-Fair Library will close at 4:30 PM on Wednesday, November 26.
Lone Star College - Cy-Fair Library will close at 4:30 PM on Wednesday, November 26.
ADA Info
Each year on November 11th, Americans celebrate Veterans Day. On this day, we honor all men and women who have served in the armed forces, whether in times of peace or war. Over the years, Hollywood has produced a number of movies that center on wars fought by the American military. Many of these films have won major awards, and they all offer insightful and, often, harrowing views of life in combat.
If you are in the mood for a war movie, browse the HCPL catalog and request one today!
Kimberly's Movie Picks:
I've said it before and I'll say it again: I adore fall. I love it not only because the leaves are changing and the temperatures are dropping, but because fall is packed with holidays. I confess that of all the fall holidays, Halloween is my least favorite, but it certainly has its advantages. Candy is, naturally, the best part of any Halloween celebration, but the movies are a close second. My personal favorite Halloween movies aren't the gory ones or the scary ones. I love the classics and the cartoons – the ones that adults and kids can enjoy together.
Have you ever had an experience that vividly reminds you of a particular movie or an episode from a TV series? Something that makes you want to curl up on the couch as soon as you get home and watch the movie? I recently spent two weeks in England, Wales and Ireland and it seemed like everything I saw reminded me of one movie or another. After the first few days, I started keeping a mental list of movies and TV shows in my head, things to watch when my vacation was over and normal life had resumed. By the end of the two weeks, the list was quite extensive!
Below is part of my mental list of movies and TV shows, along with what I saw that made me think of each one.
Kimberly's Vacation List:
Are you ready for Halloween? Don't miss the Teen Scream-In! This is a joint program between LSC-Tomball Community Library and Barbara Bush Branch Library. It will be held Friday, October 22 from 6:30pm-9:30pm (after the library closes!) at the Barbara Bush Branch Library. We will be holding a costume contest, a mad scientist laugh contest, and a Scream Queen contest. There will also be crafts, games, movies, food and lots of fun!
The Scream-In is for teens ages 12 to 17. Teens must have three signed permission forms to attend the event. Registration forms can be picked up at the Reference Desk and must be turned in by Thursday, October 21. Space is limited.
For more information, please call the Library at 832-559-4200.
Despite the scorching temperatures today, it is, as of September 22nd, officially fall! I love this time of year. In Houston we may not have the multitude of changes that sweep over other parts of the country, but we do have our own version of fall. The temperatures will (slowly) start to drop and the leaves will (eventually) change color. There will be acorns and dry leaves for crunching, pumpkins for carving and pie-making, and bonfires for marshmallow roasting. Most important of all, there will be new episodes of my favorite television shows!
If you are like me, each new TV season brings not only old favorites, but new shows I wish I had time to watch and returning shows that suddenly spark my interest. If I watched everything I wanted to, I'd never do anything else!
Books on the Bayou, an annual community-wide event, will be discussing the graphic novel Persepolis by Marjane Satrapi. Please join us for a screening of the film (rated PG-13), followed by a discussion of both the film and the graphic novel. Meet in the first floor Meeting Room (L129) on Wednesday, September 22 at 6:30 pm.
For more information, please call the Library at 832-559-4200.
Football season is here! At least that's what the radio tells me. This morning while I was sitting in traffic, I quickly noticed that every single station was discussing opening weekend, speculating on how the Texans will do this season, or finalizing fantasy football teams. I admit, this wasn't my favorite thing to listen to during my commute, but it did get me thinking about movies. I may not be the world's (or even the library's) biggest football fan, but I do like good football movies. They make me think of fall and marching bands, team spirit and hot dogs, and standing on the bleachers at
college, cheering on my team.
If you are in the mood for a football flick, browse the HCPL catalog and request a movie today!
Kimberly's Football Movie Picks:
Getting ready to take the SAT? Need to improve your scores? This month the Princeton Review is hosting a free SAT practice test here at the library. The practice test will be offered on Saturday, September 18 from 10:30am to 2:30pm. Students will be given their scores and a detailed analysis the following Saturday, September 25 from 10:30am to 12:30pm. Registration is required.
Don't forget: The library also has study guides! Check out this post for information on finding the best study guide for you.
For more information or to register for the test, call the Library at 832-559-4200.
Have you ever stopped to consider just how many types of disaster movies Hollywood has produced over the years? The Earth has almost come to an end because of natural disasters, epidemics, meteors, aliens, man-made disasters, and giant monsters – just to name a few. Why does the movie-going public have such an obsession with disaster movies? Perhaps we simply like to watch humanity battle some powerful force and, ultimately, triumph? Or maybe we just like the special effects?
If you are in the mood for a natural disaster flick, browse the HCPL catalog and request a movie today!
Kimberly's Natural Disaster Movie Picks:
Despite the excruciating temperatures, summer break is coming to a close and the school year is beginning. High school is such a defining period in any teenager's life that Hollywood directors have shot countless movies set in their halls. John Hughes and the Brat Pack are notable for some of the most iconic movies about American teenagers, but the genre has touched on all aspects of high school life. My high school days have come and gone, but I still nurture a deep appreciation for all movies set in high schools. (In fact, I think I love them more now that I don't actually have to go to school myself the next day!)
If you are feeling nostalgic about high school, getting ready to start school, or trying to convince your summer-obsessed teenager that high school is necessary, browse the HCPL catalog and request a movie today!
Kimberly's High School Movie Picks:
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The magic of play
Build your kids' imaginations and let them discover the magical world of play by building their own worlds. more
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This deliciously simple lemon slice has few ingredients, is easy to make and has great flavour. Pack it into lunch boxes or serve it for afternoon tea.
After school snacks, Cakes & Baking, Easy recipes for kids, Slice recipes
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Line a 21cm x 16 cm slice tin with baking paper and set aside.
Place biscuits, coconut, condensed milk, butter and lemon rind in a food processor. Pulse until mixture resembles fine breadcrumbs. Press the mixture into the slice tin.
To make the icing, using a mixer, beat the butter and add the lemon juice. Gradually add icing sugar. Spread over slice, sprinkle with coconut and refrigerate for 1 hour before cutting into squares.


text:
This is completely untrue. He is threatening to publish an email conversation about it. I have seen this email trail and it says nothing of the sort. Plus, I never said it!
All the councillors at the time (Joan Holmes, Nigel Clarke and I) were discussing possibilities about play areas across Brentwood West and then, on 1st October 2012, Nigel Clarke, Cllr Will Russell himself and I took a walk around potential sites for play areas in the ward as well as spending some considerable time looking at what investments could be made in Cromwell Road.
Any plans were, as far as I was concerned, not going anywhere until a resident consultation took place.
I am, however, in possession of a strategy document that was written under the Tory administration that quite clearly states that the Cromwell Road Play Area should be disposed of, and I will happily publish it.]]>
Remember the Butcher, the Baker & the Candlestick maker? Wouldn't we like to see these sort of independent traders back to the town?
The Accord administration is looking far in to the future of Brentwood and sometimes this means floating brave new ideas. That's just what we are doing with the council-owned and under-utilised Westbury Road Car Park – bringing an idea for debate and out-in-the-open discussion.
To be crystal clear – there are no current plans and we aren't forcing this on residents. We would fully consult with residents in the area for sure.
The general idea is to use some space at the front of the High Street-facing side to, potentially, create a run-on from Bennetts to include:
The objective being to establish some viable businesses at the west end of the High Street that is currently very quiet with several businesses closing down.
Now, I am broadly supportive of the objective here BUT there are issues that I need ironed out before I will support it:
I am more than happy for residents to get in touch with their thoughts on the principle of this project.]]>
Over the weekend, each household will receive a letter addressed to whoever is on the council tax account about the William Hunter Way consultation and here's why…
On 1st September 2014, after the failure of the former Tory administration's town centre development (along with eight wasted years and hundreds of thousands of pounds) the Accord administration launched a very genuine consultation – developed in consultation with local residents – that would go to every household in the borough. It was initially launched online with a paper consultation planned to go through every door.
All was going to plan until a couple of weeks ago when we started to get calls and emails from residents to say they hadn't received the consultation paper – what's worse is that this was in areas very close to the site such as Wellesley Road, Weald Road, Gerrard Crescent and huge areas in Warley.
We hoped this would right itself but, with a week to go until the consultation ends in the past week we were still hearing this from our residents and a lengthy conversation on www.streetlife.com confirmed our worst fears.
On Saturday Cllr Russell Quirk, chair of the William Hunter Way Working Group (WHWWG), called an urgent meeting of this group tonight (6th October). Councillors Quirk, Baker, Mynott, Sapwell and I met with officers at 7pm to discuss how this was going to be sorted out.
And sort it we did.
I am so pleased that we have been able to find a way to promote this consultation further at this late stage. What's better is that these "belt and braces" actions still keep us well within budget for the consultation project and assures residents that we have done everything we can to make sure every one of them has an opportunity to give us their views on the future of their town.
Make no mistake – this is important as it is about the long term future of the town which is why we are not taking it lightly."
However, even with this unfortunate series of – now solved – problems, officers have confirmed that with well over 2,000 responses already this is the best response for a Brentwood resident consultation since records began.]]>
In #Brentwoodwest this week there is an application in Firsgrove Crescent:
Please note THIS IS NOT yet a decisions – I am able to refer to planning committee now.
21 Firsgrove Crescent: PART SINGLE, PART TWO STOREY REAR/SIDE EXTENSION
Recommended for REFUSAL
If you have any issues with the above officer recommendation then please get in touch with me as soon as possible. The deadline for referral is midday on Monday 20 October 2014 to refer the above item to the Planning Committee for further discussion.
For more information on the planning process, please see my advice here.
IN ADDITION there are two Brentwood West applications being heard at the Planning Committee on Tuesday 14th October at 7pm and residents are welcome to attend:
To read of any murder is shocking, but to have it happen here on our doorstep is very upsetting indeed. The three of us would like residents who live in the area, especially around Tower Hill, Weald Road and Sir Francis Way, to know they have our support and that we are here for them if they need us. It is, without doubt, a time to come together as a community.
Essex Police have now confirmed that this is an isolated incident - possibly drug-dealing related - and they have asked us, via this email list, to give you reassurance that this was rare and doesn't seem to be a random attack or in any way connected to Brentwood's night time economy. They can say no more to us at this time.
However, detectives are appealing for anyone with any information – no matter how insignificant it may seem – to contact the police on 101. The full press release from the police is here.
We thank Essex Police for keeping us informed of the latest on this case and assure residents that we are thinking of them, especially those who are in the midst of a crime scene but again, as we have been asked to do, reassure you that this looks to be an isolated incident in our town.
Please do call us if we can help with this or any other problem.
Karen, David & John
Your Brentwood West Lib Dem Councillors
I am sure many residents are shocked to wake up and find that there's been a murder in Brentwood West – a stabbing at the junction of Sir Francis Way, Weald Road and Tower Hill.
The Brentwood Gazette reports that this happened at around 7pm last night and an air ambulance attended. Unfortunately, the poor man was declared dead at the scene. Above and beyond that, little more is known but it is important that anyone who heard or saw anything calls the police on 101 as soon as possible.
The roads are still cordoned off and nothing is being allowed to leave or enter the crime scene. Cllr John Newberry and I just want to let residents know that we are in the same position as you with regards to information, but as soon as we know any more we will endeavour to pass it on to you as quickly as we can. We would, naturally, wish to extend our condolences to the family of the man who died and let residents know that we will do all we can to help.
Published in our September 2014 newsletter, this is our usual ward round up:
- Karen and John have £1000 to spend on ward projects – please get in touch with your ideas!!!
- Tower Hill/Weald Road alleyway is being tidied and the Accord are looking to make a decision over its ongoing maintenance.
- Karen is keen to find sites for Community Orchards for foraging and education – do you know of anywhere?
- Anti social behaviour in the Railway Square/St James Road/Fairfield Road area should be reported on Telephone number 101 as the call centre staff have been warned about their rowdiness.
- We were sorry to see Bennetts window in the High Street smashed – John is working with Jane Bennett & the police on this.
- The unbelievably bright light at the station car park has been reported by Karen and, thankfully, switched off of late!
- The green in Vaughan Williams Way is also being dealt with by The Accord – the Tories just brushed this issue under the carpet!
- The green atWharf Road is unkempt and Karen has asked the council to insist the developers deal with this. Rubbish is also being cleared from the area.
- Japanese Knotweed has been reported in various locations and the council is dealing with the problem, along with Railtrack.
- Karen is working with Homesteads residents on the possibility it could be made a Conservation Area for its centenary next year.
- An application for an 8-person home of multiple occupancy (with six people sharing one toilet) in Pennyfields has been refused after Karen referred it to committee.
- Various locations are having problems with people not clearing up after their dogs – please let Karen know where so warning notices can be put up.
- Karen & John are looking to meet with the council about the state of the grounds at Tower Court that are not being maintained well.
Every single home in Brentwood is to receive a consultation paper about the future of the town centre following the Tories failed project.
Karen, who is on the WHW Working Party, said:
"I guarantee that this consultation is genuine. Following the unpleasant development the Tories wanted to foist upon us we know have a blank sheet of paper and the opportunity to get what the majority of residents want. Please, please, either fill it in online or complete the paper version and get it back to the council.
Cllr David Kendall reports back (published in our September 2015 newsletter):
- Westwood Avenue – Speed Survey: After I made representations at cabinet level, Highways have agreed to do another speed survey. I have insisted that the speed wires are installed on the straight section of the road rather than the bends as they were last time.
- Brentwood High Street: I have called for urgent repairs to be done to the road/speed tables and sections of pavement particularly around Wilsons Corner. I have been told that many of these repairs don't meet the maintenance criteria so I am now pushing for changes to made to the criteria. How many local residents have to fall over before the Tories realise action needs to be taken? It was only five years ago that the Tories spent £7million refurbishing the High Street. Sadly they don't seem to be prepared to pay the money to maintain it.
- Planned Pothole Repairs: Firsgrove Crescent, Firsgrove Road, West Park Hill & Westwood Avenue will be repaired following work by Karen, John and me.
- Street Lights – our fight continues: I recently tabled a motion at County Hall calling for Brentwood and other local authorities to be given the money to hold a referendum on the part night lighting scheme that has plunged large parts of our Borough into darkness between the hours of 12 – 5am every night. Residents have never been consulted on the issue and we wanted them to have the opportunity to express their views for or against. Surprise surprise the Tories voted against and the motion was lost but we will keep fighting your corner on this very important issue.
- Bollards at Boardman House, Rollason Way: Residents have reported that the installation of these have made a real difference to the access and egress into the car park – it's great to work together and achieve something!
- Brentwood Station – disability parking & access: I am fighting to get more parking for those with disabilities at the station. At present the only disabled parking is in the NCP but I'm trying to get some more spaces near the cab office and platform 4. A new lift is planned for platform 4 in Spring 2015.
- Pedestrian Crossing – Warley Hill: I am trying to get another pedestrian crossing on Warley Hill near to Junction Road. The opening of the new Tesco Express store has led to more residents wanting to cross this busy road and I want to try and make it as safe as possible. Highways officers will be conducting a pedestrian crossing survey and if the numbers crossing meet the criteria then I will try and push the proposal forward.
- Rollason Way parking consultation: It's sad to see that not enough residents responded to the survey for any sort of parking restrictions to be installed. This is the second survey and a project that's been worked on for three years but, it can't go any further without resident support.
- Honeypot Lane parking: Following a long campaign by local residents supported by their councillors, a decision will soon be made on providing more town centre parking for staff at the BT offices that will hopefully improve the parking issues in Honeypot Lane, Kavanaghs Road and surrounding roads. I hope to have a positive update soon.
- Diary Dates: Business Event – 2pm-6pm on Wed 29 October at Hutton Poplars Hall, Hutton. Brentwood Bus & Rail Users Association AGM – 10am on Saturday 15 November at the Town Hall.


text:
Guyana Chronicle article.
Georgetown, Guyana - Joseph `Reds' Perreira on Wednesday evening reminisced on his career as a cricket commentator at a forum held at the Georgetown Cricket Club pavilion.
WICB Media Release.
ST. JOHN'S, Antigua – Interest will remain high in the Regional 4-Day Tournament, when the final round of matches open on Friday.
Kaieteur News article.
Georgetown, Guyana - The final of the long awaited Price is Right Supermarket/Upper Corentyne Cricket Association second division cricket competition is now set for this Sunday April 13th at the No. 69 Vikings ground.
Georgetown, Guyana - Outstanding performances from Arif Chan, Manoj Looknauth and Nicholas Cameron handed Port Mourant Cricket Club (PMCC) back to back victories in the Berbice Cricket Board (BCB)/Elizabeth Styles Under-19 cricket competition which commenced recently.
West Indies Cricket Board Inc.
P.O. Box 616 W, St. John's, Antigua
Tel : 268-481-2450
Fax : 268-481-2498
Email: firstname.lastname@example.com


text:
In the continuous manufacture of disposable diapers wherein target strips applied to the diaper are cut from a pressure-sensitive adhesive tape that has a low-adhesion backsize coating, better adhesion of adhesive closure tabs to the target strips is obtained after physically abrading the low-adhesion backsize coating. A preferred abrading medium is a low density open nonwoven fibrous abrasive web.
1. In a method of continuously manufacturing disposable diapers, which method includes the steps of unwinding a roll of pressure-sensitive adhesive tape which has a backing having a thickness of less than about 40 μm that bears a low-adhesion backsize coating on its nonadhesive face, cutting the tape into pieces, and adhering at least one piece of the tape by its pressure-sensitive adhesive layer to each diaper to provide a target strip, said method being characterized by the added step of treating the tape with an abrasive surface so as to remove at least part, but not all, of the low-adhesion backsize coating on the backing with the abrasive surface having a grit size which will so remove only a portion of the backsize coating to improve peel adhesion thereof to pressure-sensitive adhesive tape.
2. Method as defined in claim 1 wherein the abrading step is carried out before the step of cutting the tape into pieces.
3. Method as defined in claim 1 and further comprising the step of cleaning from the abraded face of the tape debris created in the abrading step.
4. Method as defined in claim 1 wherein sufficient material is removed in the abrading step so that the abraded surface of the target strip has a matte appearance.
5. Method as defined in claim 4 wherein said backing is a thermoplastic film.
6. Method as defined in claim 1, wherein the abrading step abrades the low-adhesion backsize coating in a pattern of areas to provide a preselected degree of adhesion of adhesive closure tabs.
7. Method as defined in claim 6 wherein said pattern is a diamond pattern.
8. Method of continuously manufacturing disposable diapers, which method comprises the steps of
a) providing a roll of pressure-sensitive adhesive tape comprising a backing less than about 40 μm thick bearing a pressure-sensitive adhesive layer and low-adhesion backsize coating covering the nonadhesive face of the film,
b) unwinding the tape,
c) treating the low-adhesion face of the backing with an abrasive surface to remove at least part, but not all, of the low-adhesion backsize coating with the surface of having a grit size which will so remove only a portion of the backsize coating to provide a matte finish thereon with improved peel adhesion to pressure-sensitive adhesive tape,
d) cutting the tape into pieces,
e) adhering one piece of the tape to each diaper to provide a target strip.
1. Field of the Invention
The invention concerns a disposable diaper, specifically one having a target strip for a pair of adhesive closure tabs. In particular, the invention concerns the manufacture of the target strip.
2. Description of the Related Art
Disposable diapers typically have an outer shell of thin plastic film such as polyethylene, which is reinforced at the areas where adhesive closure tabs are adhered during fastening of the diaper around a wearer. The reinforcement frequently is a stronger plastic film that is adhesively attached to the outer shell and is often called a "target strip". A typical method of continuously making and applying the target strip includes the steps of: a) unwinding a roll of pressure-sensitive adhesive tape having a backing such as biaxially oriented polypropylene ("BOPP") film that has a low-adhesion backsize coating on its nonadhesive face, b) cutting the tape into pieces, and c) adhering one piece of the tape by its pressure-sensitive adhesive layer to the outer shell of each diaper to provide a target strip. While the low-adhesion backsize coating permits the tape to be unwound from the roll, it has a deleterious effect on adhesion of the adhesive closure tabs to the target strip. Although this problem can be avoided by employing a release liner instead of a low-adhesion backsize coating, doing so would be more expensive.
The problem of poor adhesion of the closure tabs to a low-adhesion backsize coating can also be avoided by coating the adhesive onto the backing film of the target strip on-line with the diaper-making operation. However, at the high speeds used in diaper-making lines, this results in an adhesive coating that may be undesirably uneven in thickness and may deviate excessively from the edges of the film.
3. Other Prior Art
U.S. Pat. No. 3,165,992 (Jeffries) concerns film adhesives that may or may not be normally tacky and typically are wound up with a double-coated release paper. Jeffries concerns the problem that after the adhesive film has been unwound and applied to an object, the release paper can be difficult to remove. Jeffries solves this problem by abrading away at least part of the release coating at one face of the release paper, thus permitting easy removal of the release paper by applying a pressure-sensitive adhesive tape to the abraded surface.
U.S. Pat. No. 3,271,229 (Grabovez) physically abrades the surface of a thermoplastic film such as poly(ethylene terephthalate) or polypropylene to provide improved slip, i.e., lower friction; the abrasion is accomplished with a brush having non-metallic bristles or fibers. U.S. Pat. No. 2,951,305 (Seymour) physically abrades poly(ethylene terephthalate) film with a wire brush in order to dull its surface appearance. Neither Grabovez or Seymour suggests that the surface being abraded might have first received any sort of coating.
The invention provides an economical method for continuously furnishing disposable diapers with target strips to which adhesive closure tabs reliably adhere. The novel method includes the above-outlined steps of continuously making and applying a target strip and so employs a roll of tape, the backing of which has a low-adhesion backsize coating.
The novel method differs from the above-outlined method by adding the step of physically abrading the low-adhesion backsize coating while the tape is being unwound to provide target strips to which adhesive closure tabs adhere more reliably.
In order to enhance handling of the tape while it is being abraded, the abrading step should be carried out prior to the step of cutting the tape into pieces. Also prior to the cutting step, there preferably is a second added step of cleaning off any debris formed in the abrading step, thus preventing the debris from interfering with a good adhesion between the adhesive closure tabs and the target strips.
The novel method provides additional advantages. For example, the abraded target strips have a matte appearance that imparts an aura of high quality to the diapers, in contrast to the shiny, and hence artificial, appearance of target strips of most disposable diapers now on the market. Such a benefit can exist irrespective of whether a low-adhesion backsize is present on the target strip, and the invention applies to such products. Furthermore, in a diaper of the invention, the adhesive closure tabs peel back smoothly from the target strip, whereas they tend to have shocky peelback from prior target strips that have low-adhesion backsize coatings. Consumers are likely to equate a smoother peelback with higher quality.
Useful materials for the target strips are those currently employed in the manufacture of target strips for diapers, e.g., high-strength thermoplastic films such as biaxially oriented polypropylene film or biaxially oriented poly(ethylene terephthalate) film, preferably having thicknesses from 15 to 40 μm. Backings that are biodegradable or otherwise environmentally degradable, e.g., cellophane, also have value.
Preferred low-adhesion backsize coatings include urethane backsizes as described in U.S. Pat. No. 2,532,011 (e.g. made by reacting octadecyl isocyanate with a polymer of vinyl alcohol), fluorochemical backsizes (such as fluorochemical acrylates described in U.S. Pat. No. 4,472,480), ultraviolet-light curable silicone backsizes described in U.S Pat. No. 4,530,879, and thermally curable backsizes described in U.S Pat. No. 4,544,635. The thickness of the low-adhesion backsize coating typically is from 0.1 to 1 μm, and it is presently contemplated that at least 10 percent of the low-adhesion backsize coating be desirably removed in the abrading step of the novel method, more preferably at least 20%. The low-adhesion backsize may be completely removed, but it is difficult to accomplish that economically and without slowing the rate at which the disposable diapers are being produced.
While the present invention can employ any of a variety of abrading tools or materials, a preferred abrading material is a low-density open nonwoven fibrous abrasive web such as is commercially available under the trademark Scotch-Brite� from the 3M Company to which this application is assigned. That abrasive web is supplied in various useful conformations such as small pads, larger sheets, discs, brushes, wheels, and rolls and is described in U.S. Pat. No. 2,958,593 (Hoover) which is incorporated herein by reference. In general, the abrasive webs are formed from randomly disposed fibers, e.g., polyesters, polyamides, nylons and rayons, which are bonded at points where they intersect to provide a three-dimensional structure; and abrasive particles are bonded to the fibers with a binder. See also, U.S. Pat. No. 4,078,340 (Klecker et al.) which is incorporated herein by reference.
Other techniques for physically abrading away at least part of the low-adhesion surface include abrasion with materials such as sandpaper and wire brushes.
The amount of material to be abraded away when using a "Scotch-Brite" low-density abrasive web can be controlled by varying a number of parameters, e.g. the fineness of its fibers, the firmness and thickness of the web, the type and loading of its abrasive particles, and the density of the web. The abrasive action of the abrasive web can also be varied in a number of ways, e.g. the speed of the web or the tape being abraded can be varied, the abrasive web can either be oscillated or held steady, the oscillation speed can be varied, the stroke distance can be varied, and the applied pressure of the abrasive web can be adjusted. Typically, a tape while being abraded is supported by a backup roll or belt which can either be smooth or patterned, e.g., a raised diamond pattern that can be chosen to cause abrasion in the patterned areas. Abrasion can be caused in a selected fraction of the area of the low-adhesion backsize coating to provide a desired degree of adhesion of adhesive closure tabs.
The action of the nonwoven abrasive web can be in only one direction or in multiple directions, e.g., first in the cross-web direction and, then in the down-web direction to provide a cross-hatched texture. Abrading techniques that are fastest and hence the most economical tend to create fine parallel grooves in the backsized surface of the target strip that afford an aesthetically pleasing matte appearance.
Debris loosened by the abrading step can be removed in various ways such as vacuuming or blowing air or by wiping with a blade, pad or brush, or by washing with water. Preferably an air knife is used to loosen the debris, and a vacuum box collects the debris. In some cases it may be desirable to use water in a washing or wiping process to clean the film produced.
In the drawings,
FIG. 1 is a schematic representation of an apparatus suitable for inclusion in equipment for the continuous manufacture of disposable diapers, which apparatus abrades and applies a target strip to each diaper; and
FIG. 2 schematically shows a disposable diaper to which a target strip has been applied as shown in FIG. 1.
The apparatus of FIG. 1 employs a roll 10 of pressure-sensitive adhesive tape 12 that has a backing 14 of high-strength thermoplastic film bearing a pressure-sensitive adhesive layer 16 and a low adhesion backsize coating 18. The tape 12 is carried into the nip between a metal roll 20 that has a release surface and a counter-rotating abrasive brush 22, specifically a Scotch-Brite� brand cleaning and finishing brush. This abrades away at least part of the low-adhesion backsize coating 18.
As the tape 12 leaves the nip, it passes beneath an air-knife vacuum manifold 24 to clean, off debris, while another vacuum manifold 26 removes debris from the abrasive brush 22 as it rotates away from the nip. The tape 12 is then fed onto a vacuum wheel 28 at which a rotary cutter 30 cuts it into pieces, each of which is adhered by the pressure-sensitive adhesive layer 16 to a diaper web 32 as an individual target strip 34, pressure being applied by a rubber pad 36 on a steel roll 38.
A disposable diaper 40 which bears one of the target strips 34 and a pair of adhesive closure tabs 42 is shown in FIG. 2.
This test employs a pressure-sensitive adhesive fastening tape, the backing of which is a polypropylene film (0.1 mm in thickness) having a matte finish on each surface (made by extruding Dypro 8771 resin available from Fina Oil and Chemical Co., colored white with 5% by weight of a blend comprising 50 weight percent each of titanium oxide and polypropylene) and bearing a pressure-sensitive adhesive layer that was coated from a solution of 45.45 parts "Kraton" 1107 elastomer (from Shell Chemical Co.), 9.09 parts mineral oil, and 45.45 parts by weight "Wingtack" 95 tackifier (from Goodyear Chemical Co.) and as dried, has a coating weight of 33.5 g/m2. "Kraton" 1107 elastomer is a styrene-isoprene-styrene block copolymer, 14% styrene, having a melt index, Cond. G, of 9.
A piece of target strip to be tested is adhered by a double-coated pressure-sensitive adhesive tape to cover a 2 inch�5 inch�1/16 inch (5.08 cm�12.7 cm�0.16 cm) smooth steel panel, with the lengthwise direction of the target strip extending in the length of the panel. A one-inch (2.54-cm) wide piece of the fastening tape is centered on the target strip and immediately rolled lengthwise, one pass in each direction, with a mechanically operated 4.5-pound (2.04-kg) roller. A peel test is carried out at constant temperature (23��2� C.) and humidity (50�2% relative humidity) using a constant-rate-extension Instron tensile tester (model 1122). Within 15 seconds after the fastening tape is rolled on the target strip, a leader of the fastening tape is clamped into the upper jaw of the tensile tester, and the crosshead peels the fastening tape at an angle of 135� at 12 inches/minute (30.5 cm/minute). The peel value is read from the chart, disregarding the portion of trace due to the initial and final 1/4 inch (0.635 cm) of the tape removed. The measurement is replicated at least twice and averaged.
At from 1 to 3 N/cm of width in this 135� Peel Adhesion Test, a target strip should provide the most reliable and conveniently usable closure for a disposable diaper. A value substantially below this range would indicate unreliable closure, or substantially above this range would indicate that some persons might have difficulty in peeling closure tabs from the target strip. However, for some uses, higher adhesion values are desirable.
In order to evaluate the roughness of abraded films of the invention, a technique described generally in U.S. Pat. No. 4,436,520 (Lipko) was used with a Surtronic 3 profilometer (from Taylor-Hobson, Leicester, U.K.). Using a stylus 5 μm in radius, the abraded surface was evaluated for Ra and Peak Count wherein Ra is the arithmetical mean deviation of the profile in μm and Peak Count is the number of peaks per cm using a bandwidth of zero.
This was measured with a 60� "Glossgard" II glossmeter (from Gardner Co., Bethesda, Md.).
The following Examples are in parts by weight and are provided to illustrate the invention but not to limit it.
A film of 10-inch (25.4-cm) width biaxially-oriented polypropylene was hot melt coated on one surface with 4 grains (17 g/m2) of adhesive formulated as 50% "Kraton" 1107 elastomer, 49% "Wingtack Plus" tackifier, and 1% "Irganox" 1076 (available from Ciba-Geigy Corp., Ardsley, N.Y.). The other surface of the resulting tape was coated with a 5% solution in xylene/heptane/isopropyl alcohol of urethane-low adhesion backsize (0.19 g/m2 dry weight) prepared from octadecyl isocyanate and polyvinyl alcohol per U.S. Pat. No. 2,532,011.
Using a Scotch-Brite� brand No. 96 general purpose scouring pad, the dried low-adhesion backsize coating was lightly abraded by hand for about 30 seconds in one direction and then 30 seconds in a direction perpendicular to the first until the glossy nature of the surface was modified to provide a texturized surface having a matte appearance. The texturized surface was then lightly wiped to remove most of the debris. In the 135� Peel Adhesion Test (using the fastening tape described below), the force to remove a fastening tape from the abraded surface was 6.75 N/cm, and to remove the fastening tape from an identical backsized film which had not been abraded, 0.66 N/cm. In this test, the backing of the fastening tape was a 5.0 mil (0.13 mm) embossed polypropylene film (made by extruding Dypro 8771 resin available from Fina Oil and Chemical, Dallas, Tex., colored white with 5% by weight of 50/50 titanium dioxide in polypropylene), and the pressure-sensitive adhesive layer (50 g/m2) consisted of 33% Kraton 1107 (available from Shell Chemical Co ), 46.9% Escorez 1310 (available from Exxon Chemical Co.) 19.1% Zonarez A-25 (available from Arizona Chemical Co.), and 1.0%, Irganox 1076 antioxidant. The fastening tape peeled smoothly from the abraded film, whereas the unabraded film produced a shocky peel.
A pressure-sensitive adhesive tape as described in the first paragraph of Example 1 was unwound at a linespeed of 40 feet (12.2 meter) per minute and passed through the nip between a metal roll and a Scotch-Brite� Cleaning and Finishing Brush Type 5S, ultrafine grade, about 8 inches (20 cm) in diameter, there being a 2 kg pressure at the nip. The rotation of the brush was in the same direction as the movement of the tape and at speeds in steps from 200 to 1000 feet (61 m to 305 m) per minute. Test results are in Table I together with the "Control" test result reported in Example 1.
TABLE I______________________________________ 135� PeelBrush Speed Adhesion Test*(fpm) (m/min) (N/cm of width)______________________________________200 61 5.0 smooth400 122 5.6 smooth600 183 5.2 smooth800 244 5.0 smooth1000 306 6.2 smoothControl 0.7 shocky______________________________________ *Using the fastening tape of Example 1
Used in these examples was 1.0 mil (0.0254 mm) biaxially oriented polypropylene film [B502 (BOPP) available from Hercules Chemical] that had been coated with a 5% solution of the urethane low-adhesion backsize (0.19 g/m2) described in Example 1. A 3-foot (39-cm) length of the film was taped at its edges to a rigid metal panel with its low-adhesion backsize coating facing outwardly. The panel was then pushed by hand through a nip between a rubber-covered roll and a counter-rotating Scotch-Brite� brand cleaning and finishing brush about 8 inches (20.3 cm) in diameter. In doing so, the panel was transported at the peripheral speed of the rubber-covered roll (9 m/min.). The various Scotch-Brite� cleaning and finishing brushes were used as indicated in Table II, namely, 7S Superfine, 5A Very Fine, and 7A Fine. Table II indicates brush roll speed and brush pressure and reports the results of peel adhesion, roughness and gloss testing of the abraded surfaces of the films of Examples 3-21. For comparative purposes, some of the films of Examples 3-21 had no low-adhesion backsize coating. Results for Examples 24C, described below, are included as another comparison.
TABLE II__________________________________________________________________________ Brush Relative 135� Peel RoughnessExampleBacksize Brush Speed Brush Adhesion Peak 60�No. Present Type (RPM) Pressure (N/cm) Ra Count Gloss__________________________________________________________________________ 3 Yes 7S 600 Low 2.0 0.25 16 -- 4 Yes " 1200 Low 2.1 0.28 33 46 5 Yes " 1200 High 2.4 0.28 59 23 6 Yes " 1800 High 2.6 0.43 77 -- 7 Yes " 1800 Low 2.1 0.30 15 34 8 Yes " 600 High 2.4 0.46 21 31 9 No " 1800 High 2.5 0.43 61 2310 Yes 5A 1200 Low 1.5 0.36 11 7411 Yes " 600 High 1.9 0.41 28 5512 Yes " 600 Low 1.5 0.28 17 8113 Yes " 1200 High 2.1 0.69 45 2714 Yes " 1800 Low 1.6 0.20 8 --15 No " 1800 High 2.7 0.56 18 3916 Yes 7A 1200 Low 1.5 0.28 14 --17 Yes " 1200 High 1.9 0.64 33 2818 Yes " 600 High 1.7 0.76 14 7019 Yes " 600 Low 1.5 0.33 15 9620 Yes " 1800 Low 1.6 0.28 19 9721 Yes " 1800 High 2.1 0.41 43 40 24CYes -- -- -- 0.86 0.17 9 134__________________________________________________________________________
A 2.2 mil (0.0559 mm) clear matte cast film made by extruding WRS-7-319, a resin consisting of polypropylene/polyethylene copolymer [available from Shell Chemical Co.], was coated with a 5% solution of the urethane low-adhesion backsize (0.38 g/m2) described in Example 1. This low-adhesion backsize coating was abraded in the same way as in Example 14 except that the brush was rotated in the same direction as the rubber-covered roll. Testing is reported in Table III together with two controls of which Example 22-C was an identical tape that was not abraded, and Example 22-CC was an abraded identical tape except having no low-adhesion backsize coating.
TABLE III______________________________________ RoughnessExample 135� Peel PeakNo. Adhesion Ra Count______________________________________22 2.0 1.27 10122-C 1.2 -- --22-CC 2.6 0.91 122______________________________________
Used to make target strips was a roll of 10-inch width (25.4-cm) biaxially oriented polypropylene film (BOPP) bearing on one surface a pressure-sensitive adhesive and on the other surface a coating with 5% by weight of urethane low-adhesion backsize (0.19 g/m2) as in Example 1. While being unwound at a linespeed of 100 feet per minute (30.5 m/min.), this tape was passed between a rotating idler roll and an abrading brush (Scotch-Brite� 5A fine cleaning and finishing brush) of about 8 inches (20.3 cm) in diameter and 10 inches (25.4 cm) in width that was counter rotated at a 3.25 rpm dial setting. The roll pressure was maintained at 50 psi (34 N/cm2). The generated debris was then removed by a combination vacuum and air knife. Static eliminators were also mounted in the line immediately above the abrading brush. Test results are shown in Table IV, which also reports the residual amount of urethane backsize after abrasion, determined by infrared spectroscopic measurements that compare the urethane absorption present before and after abrasion. Also reported in Table IV as Example 23-C (a control) is testing of an identical tape that was not abraded.
Example 23 was repeated except using BOPP that had no adhesive coating and using a different rpm of the abrading brush as indicated in Table IV. Also reported in Table III as Example 24-C is an unabraded control.
TABLE IV______________________________________ Residual 135� Peel Urethane AdhesionExample Linespeed RPM Level on TestNo. (m/min) Setting Surface (N/cm)______________________________________23 30.5 3.25 34% 1.524 30.5 9 88% 1.725 30.5 3.25 14% 1.823-C -- -- 100% 1.124-C -- -- 100% 0.86______________________________________
As noted above, the matte appearance afforded by abrading the surface of a thermoplastic film imparts an aura of quality as compared to unabraded film. For this reason, it may be desirable for the target strip of a diaper to have an abraded surface, whether or not the surface being abraded originally carried a low-adhesion backsize coating. Furthermore, the degree of adhesion of a diaper closure tab to a target strip changes when the exposed surface of the target strip is abraded, whether or not a low-adhesion backsize coating had previously been applied to that surface or was applied after it had been abraded. These and other facets of the invention will occur to one skilled in the art.
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4.64 out of 5
While the product is easy to install, and actually looks good, the availability of various hangers and hooks leave much to be desired. After visiting 5 different stores, I have yet to find 'scoop hooks', yet they are prominently displayed in photos a....
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Added Oct 18, 2013
by staticstasy
Athens, Greece
Here is a waistcoat I made for my boyfriend to wear at the Fresher's Fair at my uni to advertise our new Sewing and Ethical Fashion Society! Made entirely out of second hand clothes. I drafted the pattern from my new menswear patterncutting book. I made it the day before and hemmed it on the day, so it isn't the neatest thing I've ever made, but it did the job!
Oct 19, 2013, 07.51 PMby Mary Athey
Great idea and the embroidary's lovely x
Oct 22, 2013, 10.56 AMby staticstasy
Thank you! It is actually applique! :)
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