text:
Among gastrointestinal stromal tumors (GISTs) of 10–15% are negative for KIT and PDGFRA, and most of these cases are SDH deficient. Recent studies have provided data on additional molecular alterations such as KRAS in KIT mutant GISTs. We aimed to assess the frequency and spectrum of somatic mutations in common oncogenes as well as copy number variations in GISTs negative for KIT and PDGFRA mutations. GISTs with wild type KIT/PDGFRA were tested via next generation sequencing for somatic mutations in 341 genes. SDHB immunohistochemistry to evaluate for SDH deficiency was also performed. Of 267 GISTs tested for KIT and PDGFRA mutations, 15 were wild type, of which eight cases had material available for further testing. All eight cases had loss of SDHB expression and had various molecular alterations involving ARID1A, TP53, and other genes. One case had a KRAS G12V (c.35G>T) mutation in both the primary gastric tumor and a post-imatinib recurrence. This tumor had anaplastic features and was resistant to multiple tyrosine kinase inhibitors, ultimately resulting in cancer-related mortality within 2 years of diagnosis. In conclusion, KRAS mutations occur in rare GISTs with wild type KIT and PDGFRA. These tumors may display immunohistochemical positivity for KIT and primary resistance to tyrosine kinase inhibitors. © 2014 Wiley Periodicals, Inc.]]>
Gene amplification is relatively common in tumors. In certain subtypes of sarcoma, it often occurs in the form of ring and/or giant rod-shaped marker (RGM) chromosomes whose mitotic stability is frequently rescued by ectopic novel centromeres (neocentromeres). Little is known about the origin and structure of these RGM chromosomes, including how they arise, their internal organization, and which sequences underlie the neocentromeres. To address these questions, 42 sarcomas with RGM chromosomes were investigated to detect regions prone to double strand breaks and possible functional or structural constraints driving the amplification process. We found nine breakpoint cluster regions potentially involved in the genesis of RGM chromosomes, which turned out to be significantly enriched in poly-pyrimidine traits. Some of the clusters were located close to genes already known to be relevant for sarcomas, thus indicating a potential functional constraint, while others mapped to transcriptionally inactive chromatin domains enriched in heterochromatic sites. Of note, five neocentromeres were identified after analyzing 13 of the cases by fluorescent in situ hybridization. ChIP-on-chip analysis with antibodies against the centromeric protein CENP-A showed that they were a patchwork of small genomic segments derived from different chromosomes, likely joint to form a contiguous sequence during the amplification process. © 2014 Wiley Periodicals, Inc.]]>
Increasing evidence indicates the high heterogeneity of cancer cells. Recent studies have revealed distinct subtypes of DNA methylation in colorectal cancer (CRC); however, the mechanism of heterogeneous methylation remains poorly understood. Gene expression is a natural, intermediate quantitative trait that bridges genotypic and phenotypic features. In this work, we studied the role of heterogeneous DNA methylation in tumorigenesis via gene expression analyses. Specifically, we integrated methylation and expression data in normal and tumor tissues, and examined the perturbations in coexpression patterns. We found that the heterogeneity of methylation leads to significant loss of coexpression connectivity in CRC; this finding was validated in an independent cohort. Functional analyses showed that the lost coexpression partners participate in important cancer-related pathways/networks, such as ErbB and mitogen-activated protein kinase (MAPK) signaling pathways. Our analyses suggest that the loss of coexpression connectivity induced by methylation heterogeneity might play an important role in CRC. To our knowledge, this is the first study to interpret methylation heterogeneity in cancer from the perspective of coexpression perturbation. Our results provide new perspectives in tumor biology and may facilitate the identification of potential biomedical therapies for cancer treatment. © 2014 Wiley Periodicals, Inc.]]>
To recommend a reliable and clinically realistic RET/PTC rearrangement detection assay for papillary thyroid carcinoma (PTC), we compared multiplex quantitative polymerase chain reaction (qPCR), fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). RET/PTC rearrangement was detected using either RET break-apart FISH followed by multicolor FISH to confirm CCDC6/RET or NCOA4/RET fusions, or by multiplex qPCR to detect 14 RET/PTC subtypes with simultaneous RET mRNA expression. RET protein expression was detected by IHC. The specificity and sensitivity of multiplex qPCR and IHC were calculated using break-apart FISH as a reference. Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA. In addition, multiplex qPCR identified another two CCDC6/RET fusion positive cases, but with low RET mRNA expression. IHC staining identified 11 RET positive cases among 39 patients with available samples. In comparison to FISH, multiplex qPCR displayed 100% sensitivity and 97% specificity to detect RET/PTC fusions, while IHC was neither sensitive nor specific. Our data reveal that both multiplex qPCR and FISH assays are equally applicable for detection of RET/PTC rearrangements. Break-apart FISH methodology is highly recommended for the wider screening of RET rearrangements (regardless of partner genes), while multiplex qPCR is preferred to identify all known fusion types using one assay, provided mRNA expression is also measured. IHC analysis could potentially provide an additional method of fusion detection dependent on further optimization of assay conditions and scoring cutoffs. © 2014 Wiley Periodicals, Inc.]]>
Chromodomain helicase DNA-binding protein 4 (CHD4) plays a pivotal role in chromatin-remodeling and has been implicated in the development of cancer. The aim of this study is to determine the association of CHD4 gene variants with cancer. Nine missense single nucleotide variations (SNVs) in CHD4 were retrieved from genotyping, by an exome-chip, 2,343 consecutive autopsy cases, in which the presence or absence of cancer was pathologically reviewed. The association of CHD4 variants with the presence of cancer and with different types of cancer was determined. Interaction with smoking was also determined. There were 1,446 patients with cancer and 897 patients without cancer. Of the nine SNVs, eight SNVs were monomorphic, while two nonsynonymous SNVs; rs7479004 (p.D140E) and rs1639122 (p.E139D) were further verified by direct sequencing. The p.D140E was associated with the presence of cancer (adjusted odds ratio [OR], 2.17; 95% confidence interval [CI], 1.37–3.44, P = 0.001), but not p.E139D. The effect size was larger in the smokers (adjusted OR, 4.66; 95% CI, 1.82–11.9; P =0.001), suggesting that there may be a gene environment interaction. For individual cancer types, p.D140E was associated with lung cancer (adjusted OR, 3.99; 95% CI, 2.07–7.67; P < 0.001), malignant lymphoma (adjusted OR, 3.24; 95% CI, 1.43–7.33; P = 0.005), and rectum cancer (adjusted OR, 6.23; 95% CI, 2.31–16.8; P < 0.001). A nonsynonymous SNV of CHD4, p.D140E, confers a risk of cancer and may interact with smoking habit to increase the risk. © 2014 Wiley Periodicals, Inc.]]>
Risk stratification in myeloma requires an accurate assessment of the presence of a range of molecular abnormalities including the differing IGH translocations and the recurrent copy number abnormalities that can impact clinical behavior. Currently, interphase fluorescence in situ hybridization is used to detect these abnormalities. High failure rates, slow turnaround, cost, and labor intensiveness make it difficult and expensive to use in routine clinical practice. Multiplex ligation-dependent probe amplification (MLPA), a molecular approach based on a multiplex polymerase chain reaction method, offers an alternative for the assessment of copy number changes present in the myeloma genome. Here, we provide evidence showing that MLPA is a powerful tool for the efficient detection of copy number abnormalities and when combined with expression assays, MLPA can detect all of the prognostically relevant molecular events which characterize presenting myeloma. This approach opens the way for a molecular diagnostic strategy that is efficient, high throughput, and cost effective. © 2014 The Authors. Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc.]]>
Barrett's esophagus (BE) goes through a sequence of low grade dysplasia (LGD) and high grade dysplasia (HGD) to esophageal adenocarcinoma (EAC). The current gold standard for BE outcome prediction, histopathological staging, can be unreliable. TP53 abnormalities may serve as prognostic biomarkers. TP53 protein accumulation detected by immunohistochemistry (IHC) indirectly assesses TP53 mutations. DNA fluorescent in situ hybridization (FISH) on brush cytology specimens directly evaluates gene locus loss. We evaluated if IHC and FISH are complementary tools to assess TP53 abnormalities and tested their prognostic value in a long-term prospective follow-up of a BE cohort. TP53 IHC on tissue sections and FISH on brush cytology specimens were evaluated for 116 BE patients with respect to the different histological stages. The TP53 abnormalities were further studied in a panel of cell lines representative of the Barrett's carcinogenic sequence. For 91patients, the predictive value of TP53 abnormalities with respect to progression to HGD/EAC was tested after long term follow-up. The frequency of IHC and FISH TP53 abnormalities increased significantly with increasing histological stage (P < 0.001, Chi2-test). Combining the techniques detected TP53 abnormalities in 100% of patients with LGD, HGD, and EAC. Multivariate analysis showed that IHC (hazard ratio: 17, 95% CI: 3.2–96, P = 0.001) and FISH (hazard ratio: 7.3, 95% CI: 1.3–41, P = 0.02) were both independent significant predictors of progression. Combining FISH and IHC in assessing TP53 abnormalities leads to an increased detection rate of TP53 aberrations and improved accuracy for predicting BE progression. © 2014 Wiley Periodicals, Inc.]]>
Anaplastic lymphoma kinase (ALK) has been demonstrated to be deregulated in sporadic as well as in familiar cases of neuroblastoma (NB). Whereas ALK-fusion proteins are common in lymphoma and lung cancer, there are few reports of ALK rearrangements in NB indicating that ALK mainly exerts its oncogenic capacity via activating mutations and/or overexpression in this tumor type. In this study, 332 NB tumors and 13 cell lines were screened by high resolution single nucleotide polymorphism microarray. Gain of 2p was detected in 23% (60/332) of primary tumors and 46% (6/13) of cell lines, while breakpoints at the ALK locus were detected in four primary tumors and two cell lines. These were further analyzed by next generation sequencing and a targeted enrichment approach. Samples with both ALK and MYCN amplification displayed complex genomic rearrangements with multiple breakpoints within the amplicon. None of the translocations characterized in primary NB tumors are likely to result in a chimeric protein. However, immunohistochemical analysis reveals high levels of phosphorylated ALK in these samples despite lack of initial exons, possibly due to alternative transcription initiation sites. Both ALK proteins predicted to arise from such alterations and from the abnormal ALK exon 4–11 deletion observed in the CLB-BAR cell line show strong activation of downstream targets STAT3 and extracellular signal-regulated kinase (ERK) when expressed in PC12 cells. Taken together, our data indicate a novel, although rare, mechanism of ALK activation with implications for NB tumorigenesis. © 2014 Wiley Periodicals, Inc.]]>
Molecular genetic studies on vascular tumors are rare. Recently, possible involvement of MYC and KDR has been documented in a subset of angiosarcomas of soft tissue. We performed a cytogenetic analysis of primary angiosarcomas of bone (n = 13) and soft tissue (n = 5) using high density array-comparative genomic hybridization (array-CGH). Regions of interest were validated by fluorescence in situ hybridization (FISH). Antibodies for candidate genes (SKI, MYC, KDR, and MAPK9) were selected and immunohistochemistry was performed. Six angiosarcomas of bone and four angiosarcomas of soft tissue showed chromosomal losses, gains, and high level amplifications. Cluster analysis identified two groups: a group with a complex genetic profile and a group with only few genetic aberrations. Five regions of interest were selected, which were located at chromosome bands 1p36.23, 2q32-34, 5q35, 8q24, and 17q21.32-24.2. Interphase FISH confirmed the high-level amplifications. Immunohistochemical analysis showed high expression of MYC (16/60), MAPK9 (63/69), and SKI (52/62). There were no differences between the two groups with regards to location, immunohistochemical expression nor survival. In summary, we identified two subgroups of angiosarcoma: those with few or no gross aberrations and those which show numerous genetic aberrations consisting of chromosomal losses, gains and high level amplifications or complex aberrations. The most common finding was amplification of 2q and 17q in both angiosarcoma of bone and soft tissue, suggesting overlap in tumorigenesis irrespective of their location. We show MYC amplification in primary angiosarcoma indicating this is not entirely specific for radiation-induced angiosarcoma. © 2014 Wiley Periodicals, Inc.]]>
The genetics of myoepithelial tumors (ME) of soft tissue and bone have recently been investigated, with EWSR1-related gene fusions being seen in approximately half of the tumors. The fusion partners of EWSR1 so far described include POU5F1, PBX1, ZNF444 and, in a rare case, ATF1. We investigated by RNA sequencing an index case of EWSR1-rearranged ME of the tibia, lacking a known fusion partner, and identified a novel EWSR1-PBX3 fusion. The fusion was further validated by reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization (FISH). To evaluate if this is a recurrent event, an additional cohort of 22 EWSR1-rearranged ME cases lacking a fusion partner were screened by FISH for abnormalities in PBX3 gene. Thus, two additional cases were identified showing an EWSR1-PBX3 gene fusion. One of them was also intraosseous involving the ankle, while the other occurred in the soft tissue of the index finger. The morphology of the EWSR1-PBX3 fusion positive cases showed similar findings, with nests or sheets of epithelioid to spindle cells in a partially myxoid to collagenous matrix. All three cases showed expression of S100 and EMA by immunohistochemistry. In summary, we report a novel EWSR1-PBX3 gene fusion in a small subset of ME, thereby expanding the spectrum of EWSR1-related gene fusions seen in these tumors. This gene fusion seems to occur preferentially in skeletal ME, with two of the three study cases occurring in intraosseous locations. © 2014 Wiley Periodicals, Inc.]]>
Ovarian cancer is the fifth most common cause of cancer death in women worldwide. Serous epithelial ovarian cancer (SEOC) is the most common and aggressive histological subtype. Widespread genomic alterations go hand-in-hand with aberrant DNA damage signaling and are a hallmark of high-grade SEOC. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that are nonrandomly distributed in the genome. They are frequently located in chromosomal regions susceptible to copy number variation (CNV) associated with malignancy that can influence their expression. Widespread changes in miRNA expression have been reported in multiple cancer types including ovarian cancer. This review examines CNV and single nucleotide polymorphisms, two common types of genomic alterations that occur in ovarian cancer, in the context of their influence on the expression of miRNA and the ability of miRNA to bind to and regulate their target genes. This includes genes encoding proteins involved in DNA repair and the maintenance of genomic stability. Improved understanding of mechanisms of miRNA dysregulation and the role of miRNA in ovarian cancer will provide further insight into the pathogenesis and treatment of this disease. © 2014 Wiley Periodicals, Inc.]]>
We performed single nucleotide polymorphism (SNP) array analysis of 35 newly diagnosed symptomatic multiple myeloma (MM) patients who received bortezomib-melphalan-prednisone (VMP) to identify collaborating genetic events that could predict the outcome of treatment. A total of 340 copy number variations (CNVs) were identified, with the most frequently identified CNVs being gains on 1q, 19p, 9q, 3q, 9p, 15q, 19q, 5q, 11q, 5p, and 7q and losses on 1p, X, 13q, 14q, and 6q. The number and proportion of detected abnormalities by SNP array were associated with presence of cytogenetic abnormalities and complex karyotype. Moreover, increasing genomic complexity as ascertained by SNP arrays correlated with outcome of the VMP treatment. The frequency of CNVs was significantly different according to achievement of very good partial response (VGPR) to VMP treatment (<VGPR vs. ≥VGPR, median 11.7 vs. 7.7, respectively, P = 0.032) or occurrence of progressive disease (PD) after VMP treatment (progression vs. nonprogression, median 11.6 and 6.5, respectively, P = 0.011). The proportion of CNV length was also significantly higher in patients who did not achieve VGPR compared with those with ≥VGPR (median 31.9 vs. 19.6%, respectively, P = 0.004) and also higher in patients with PD compared with those without it (median 31.9 vs. 15.8%, respectively, P = 0.005). The patients who did not achieve VGPR tended to have deletion of 1p (P = 0.011) and gain of 3q (P = 0.05). Occurrence of PD was associated with complex karyotype (P = 0.020) and gain of 3q (P = 0.022). Our data show that the occurrence of CNVs correlates with clinical outcomes to first-line VMP treatment. © 2014 Wiley Periodicals, Inc.]]>
Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue tumor exhibiting considerable morphologic overlap with low-grade fibromyxoid sarcoma (LGFMS). Moreover, both SEF and LGFMS show MUC4 expression by immunohistochemistry. While the majority of LGFMS cases are characterized by a FUS-CREB3L1 fusion, both FUS-CREB3L2 and EWSR1-CREB3L1 fusions were recently demonstrated in a small number of LGFMS and SEF/LGFMS hybrid tumors. In contrast, recent studies pointed out that SEF harbor frequent EWSR1 rearrangements, with only a minority of cases showing FUS-CREB3L2 fusions. In an effort to further characterize the molecular characteristics of pure SEF and hybrid SEF/LGFMS lesions, we undertook a clinicopathologic, immunohistochemical and genetic analysis of a series of 10 SEF and 8 hybrid SEF/LGFMS tumors. The mortality rate was similar between the two groups, 44% within the pure SEF group and 37% in the hybrid SEF/LGFMS with a mean overall follow-up of 66 months. All but one pure SEF and all hybrid SEF/LGFMS-tested cases showed MUC4 immunoreactivity. The majority (90%) of pure SEF cases showed EWSR1 gene rearrangements by fluorescence in situ hybridization with only one case exhibiting FUS rearrangement. Of the nine EWSR1 positive cases, six cases harbored CREB3L1 break-apart, two had CREB3L2 rearrangement (a previously unreported finding) and one lacked evidence of CREB3L1/2 abnormalities. In contrast, all hybrid SEF/LGFMS tumors exhibited FUS and CREB3L2 rearrangements. These results further demarcate a relative cytogenetic dichotomy between pure SEF, often characterized by EWSR1 rearrangements, and hybrid SEF/LGFMS, harboring FUS-CREB3L2 fusion; the latter group recapitulating the genotype of LGFMS. © 2014 Wiley Periodicals, Inc.]]>
Three studies have reported that BRCA1/2 mutations of paternal origin confer an earlier age at breast cancer diagnosis compared with maternal origin. The primary aim of this study was to investigate the impact of parental origin of BRCA1/2 mutations on age at breast and ovarian cancer diagnosis. This study included 577 female BRCA1/2 mutation carriers. All BRCA1/2 mutation carriers belonged to families registered between 1993 and 2011 at the Oncogenetic Clinic at Skånes University Hospital, Lund, Sweden. Cox proportional hazard ratios were used to analyze time to breast or ovarian cancer diagnosis. A novel finding was that carriers of BRCA1 mutations of paternal origin were 4 years older at age of ovarian cancer (P = 0.009) compared with those carrying a BRCA1 mutation of maternal origin. BRCA1 carriers with mutations of paternal origin were 4 years younger at breast cancer diagnosis (P = 0.017) compared with those carrying a BRCA1 mutation of maternal origin, which is in agreement with three previous studies. Both findings were adjusted for of year of inclusion, birth date, and oral contraceptive pill use. No associations between parental origin of BRCA2 mutations and time to breast or ovarian cancer diagnosis were found. An attempt to handle a potential selection bias regarding use of oral contraceptives was made using multiple imputations by chained equations. The observed age difference may allow a greater understanding of mechanisms associated with the differences in cancer penetrance in BRCA1/2 mutation carriers, some of which may depend on paternal origin. © 2014 Wiley Periodicals, Inc.]]>
Inherited loss-of-function mutations in the BAP1 oncosuppressor gene are responsible for an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and keratinocytic melanoma, and other malignancies. Germline mutations that were inherited in an autosomal dominant fashion were identified in nine families with multiplex MM cases and 25 families with multiple melanoma, renal cell carcinoma, and other tumors. Germline mutations were also identified in sporadic MM cases, suggesting that germline mutations in BAP1 occur frequently. In this article, we report the analysis of BAP1 in five multiplex MM families and in 103 sporadic cases of MM. One family carried a new truncating germline mutation. Using immunohistochemistry, we show that BAP1 is not expressed in tumor tissue, which is in accordance with Knudson's two hits hypothesis. Interestingly, whereas the three individuals who were possibly exposed to asbestos developed MM, the individual who was not exposed developed a different tumor type, that is, mucoepidermoid carcinoma. This finding suggests that the type of carcinogen exposure may be important for the cancer type that is developed by mutation carriers. On the contrary, the other families or the 103 sporadic patients did not show germline mutations in BAP1. Our data show that BAP1 mutations are very rare in patients with sporadic MM, and we report a new BAP1 mutation, extend the cancer types associated with these mutations, and suggest the existence of other yet unknown genes in the pathogenesis of familial MM. © 2014 Wiley Periodicals, Inc.]]>


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text: From Cleveland.Com "Contrary to published reports, Blank said Givens is not committed to finding a team that would anoint him its No. 1 receiver. "Every team we've looked at has a No. 1," Blank said. "Braylon Edwards is the Cleveland Browns' No. 1, if he's healthy. David's not looking to catch 100 balls a year. He's looking at doing what he did at New England, which was play an important role."


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Unigine OilRush Game Is Coming To Steam
Published on 22 March 2011 01:07 PM EDT
Written by
Michael Larabel
16 Comments
OilRush game
has been
available for pre-order
for a few weeks now (which also grants users access to betas of this real-time strategy game until its June launch), but to date they've sold less than 1,200 copies. Fortunately, there's two major changes to be announced very soon.
As of right now, OilRush has sold just 1139 copies. Most of the copies continue going to Linux users (1016 users) while there's been just 123 sales. They have announced work on
a Mac OS X port of OilRush
, but it isn't ready quite yet. However, Unigine Corp is preparing to make two more announcements that will hopefully further drive pre-orders.
- Unigine Corp is working on Valve's Steam integration. Existing OilRush orders should seamlessly migrate to Steam.
- When that comes, when ordering OilRush a single key will work across the Windows, Linux, and Mac OS X versions of OilRush. You don't need to buy multiple copies in order to play the same game under different operating systems.
Look for an official announcement in the coming days. Don't forget we're also
giving away copies of Unigine OilRush
in an easy contest.
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German Longhaired Pointer wins HPR Championship
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Cancer detection dog receives charity medal
Dogs have changed my life By Jon-Paul Church, 13, from Dyfed, Wales
I have been showing for four years and dogs have changed my life because when Im by myself my dogs keep me company and entertained. When I had my first dog I was so excited we named her Lucy and she was a Border Collie. After school or on the...
Jodie glams it up at dog party - by Jodie Forbes, 17, from Bournemouth
Im sure everybody has celebrated their pets birthday before; given them a present, perhaps made a cake. If your dog is especially spoilt you may even have invited some of their doggy friends over and had a party.
Handle with care - Choosing the perfect show lead by Marina Scott
THE LEAD is the only thing which links you to your dog and when in the show ring this lead control is ultimately what can make or break your dogs performance. Therefore, when preparing your dog for the show ring, using the correct show lead...
Tell Marina
Show lead horror stories, favourite leads and tips youve been sharing on the Paws... for Youth Facebook page.
Junior stories from Christmas by Elise OConnor, 12, Worcestershire
ON December 22 we went to Redditch limit show. Honey and Panda won everything they were entered in. I won my handling class, and then to top it all off Panda won reserve best in show! We really enjoyed the Christmas atmosphere including the food...
Junior stories from Christmas by Laura Camilletti, 17, Kent
My Christmas holidays were full of family, friends and food! Our Rhodesian Ridgebacks enjoyed their holiday and rest during the not so busy show season, and loved taking part in consuming some of the Christmas dinner turkey!
Stay calm, enjoy and have fun! By Sarah Gibbons and Haley Jones
As 2013 draws to a close, its time to look forward to 2014 and what it may bring. Many young handlers will be looking at the upcoming year, hoping this is going to be the year of their dreams, but what titles can they gain and what can help them...
Charlotte joins dog show committee by Victoria Wilkins
Charlotte Page, 18, from Cambridgeshire, has been announced as the new member of the East of England dog show committee. Growing up with dogs was a regular thing for Charlotte and she now actively participates in championship shows around the...
Its beginning to look a lot like Christmas by Averil Cawthera-Purdy
FOR ME LKA has always heralded the start of Christmas. This probably dates back to the years when many breeds held unofficial Christmas parties at the show. These days its still the show where I gauge how far behind I am with Christmas preparations!
Will is the first male winner in 14 years by Victoria Wilkins
SIXTEEN-YEAR-OLD Will Croxford, from Thrapston, Northamptonshire, was crowned the winner of the Junior Handling Associations final competition.
To question or not to question? by Averil Cawthera-Purdy
RACHEL Horler started a string on the Facebook page following a handling judge asking a veterinary care question to the handlers at a recent show. They asked if your dog had blood in his sick would you take to the vets?
Do you know an outstanding young person that deserves to be recognised at Crufts?
The Young Kennel Club (YKC) is asking for the publics help in finding the next winner of its Shaun McAlpine Outstanding Young Person of the Year Award.
Will takes the top spot in junior handling
WILL CROXFORD, 16, from Thrapston, Northamptonshire, was Helena Hutchings Junior Handler of the Year winner.
The regulations around handling by Averil Cawthera-Purdy
I WAS VERY interested in Jayne Mills post on Paws on Facebook (scroll back a couple of weeks and youll find it). She spotted that YKC handling and stakes qualifying results, published on the YKC website show of first places being wasted as they...
Young Kennel Club art competition is back for 2013 by Victoria Wilkins
THE POPULAR Young Kennel Club (YKC) childrens art competition is back and this years theme is dogs on holiday.
Braving the handling minefield
IVE PICKED up on a FB post from Denise Ford to concentrate on this week and Im sure many others new to handling will have had similar thoughts.
Victoria wants to showcase exhibitor opinion By Victoria Wilkins
YKC member Victoria Woods is 24 years old and in her third year studying Veterinary Medicine at the University of Nottingham Veterinary School.
Time for a handling JDP? by Averil Cawthera-Purdy
In my last YHIS I touched on judges and judging of handling. However, following the posts on PAWS FB it is evident that judges and judging standards are ranking as the number one by some way as needing improvement to support the development of...
Help Lisa Moir with her bursary entry!
Have you seen this bursary entry from Lisa Moir? If not, take a look and vote! She champions considerable points in dog welfare. Voting closes in just 3 days and Lisa could be in with a chance of winning as she is sitting in 11th place...
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Connie Millar discusses the basic principles of ecosystem management (EM), specifically in national forests in California and nearby states.
Homer, AK, located 125 miles southwest of Anchorage, has a current population of approximately 5,700. Positioned along the shore of Kachemak Bay, Homer has expansive views of glaciers, forests, and mountains. Residents and tourists alike enjoy the strong sense of community found in Homer and the many options for outdoor recreation such as kayaking, fishing, and wildlife viewing.
Climate change is the primary long-term challenge facing Oregon's people, ecosystems, and economies. Immediate action is needed to prepare for and proactively adapt to the consequences of climate change. State-level preparedness will be critical in coping with projected changes such as increased temperatures, rising sea levels and increased storm surges, declining snowpack, more frequent extreme precipitation events, and an increased risk of drought and heat waves. These changes have already created a broad array of secondary effects in Oregon's ecosystems.
Since publishing Seasons' End: Global Warming's Threat to Hunting and Fishing, the urgency to address the effects of climate change on fish and wildlife has become increasingly evident. Already waterfowl exhibit changes in seasonal distribution. Higher water temperatures and diminished stream habitat are threatening coldwater fish such as trout and salmon. Big game are shifting to more northerly latitudes and to higher elevations to escape summer heat and find suitable forage.
In collaboration with several other partners, the Ministry runs the Danish portal for Climate Change Adaptation.


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High School
M-E clinches division title with win over JC
Johnson City, NY (WBNG Binghamton) Maine-Endwell jumped out to a 26-0 halftime lead against rival Johnson City on Saturday and didn't look back. The Spartans won their 45th straight game, beating JC 42-0.
Seton clinches playoff birth, pounds Candor, 55-14
Binghamton (WBNG BINGHAMTON) Seton Catholic earned its first playoff berth under head coach Brian Mister, trouncing Candor, 55-14, at Alumni Stadium.
Norwich scores 17 unanswered, tips Sabers in OT, 20-17
Norwich (WBNG BINGHAMTON) Trailing 17-3 at halftime, Norwich halfback Michael Oralls scored a pair of second half touchdowns to force overtime before Zan Stewart knocked in a 19-yard field goal to give the Purple Tornado a 20-17 win over a division rival.
Vestal, Unatego, Elmira earn wins
Binghamton, NY (WBNG Binghamton) Elmira and Binghamton entered Friday as the two highest scoring teams in Section IV football, and the game didn't disappoint. The Express scored more though, beating the Patriots 47-27.
High school football gallery (Week 7)
(WBNG Binghamton) A look at some of the images of Week 7 of the high school football season in Section IV.
Oneonta earns spot in STAC title game
Elmira, NY (WBNG Binghamton) Down 1-0, the Oneonta girl's soccer team scored three unanswered goals to comeback and win its STAC semifinal game 3-2 over Elmira.
Vestal edges M-E in girl's soccer
Vestal, NY (WBNG Binghamton) Courtney Franz scored on a header off of an Emily Wirth corner for the Vestal girl's soccer team.
Forks remains ranked first in latest state football rankings
(WBNG Binghamton) Despite losing to Maine-Endwell on Friday night, Chenango Forks remained ranked first in the state in Class C in the latest football rankings released by the New York State Sportswriters Association on Wednesday.
Soccer roundup: Indians net big road win over Sabers
Conklin (WBNG BINGHAMTON) Owego pitched a shutout on the road against Susquehanna Valley, blanking the Sabers, 2-0. Tuesday also saw Johnson City remain undefeated and Vestal top Maine-Endwell in an overtime thriller.
Spartans in "great shape" after beating Forks
Town of Union (WBNG BINGHAMTON) With a 20-7 win over Forks, M-E has to like where it's going. The Spartans are now 6-0 and winners of 44 straight.
Most Viewed
The Spartan way
Forks "has its hands full" with Hoosick Falls
M-E 'builds' off semifinal win, ready for Norwich
State football rankings released ahead of Section IV finals
Spotlight on the Spartans: M-E prepares for state title rematch
Section IV places nine teams in latest state football rankings
Spartan explosion: M-E rips Cheektowaga en route to the Dome
Chenango Forks comes full circle
Seton shocks Walton; advances to Class D semis
Football state semifinals schedule (UPDATED)


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July 23 (Bloomberg) -- Karl-Ludwig Kley, chief executive officer of Merck Germany, talks about the company's business strategy and growth plans for China.
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NEW!!!! Church Family Information Update Form
Again, the kingdom of heaven is like unto a net, that was cast into the sea, and gathered of every kind:
Which, when it was full, they drew to shore, and sat down, and gathered the good into vessels, but cast the bad away.
So shall it be at the end of the world: the angels shall come forth, and sever the wicked from among the just,
And shall cast them into the furnace of fire: there shall be wailing and gnashing of teeth.
Jesus saith unto them, Have ye understood all these things? They say unto him, Yea, Lord.
Then said he unto them, Therefore every scribe which is instructed unto the kingdom of heaven is like unto a man that is an householder, which bringeth forth out of his treasure things new and old.


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Home » News » Public Safety
Nashua offers disaster training
"A prepared citizenry is the most valuable asset the government has in dealing with an emergency," said Lozeau. "I encourage residents to participate in this opportunity."
Two upcoming courses have been scheduled and 20 people have already signed up, said Emily Martuscello, an EMT and intern with the city's Office of Emergency Management. She is hopeful that each class will be filled to its capacity of 25 participants.
"If a catastrophic event happened, we need a lot of community members who are trained with basic skills to assist," said Martuscello. "Preparedness is everyone's responsibility, and Nashua residents seem willing to learn and be prepared. We have had a great response from the members of the community already."
Throughout the free emergency preparedness training, participants will learn how to provide basic medical aid, search for and rescue victims safely, manage utilities, put out small fires, and prepare for natural or man-made disasters.
The Community Emergency Response Team program is an all-risk, all-hazard training, according to a release. Participants will receive national certification as a CERT member upon completion. The course will cover terrorism awareness, an introduction to incident command, and hands-on teaching by emergency management experts, according to the release issued by Justin Kates, the city's emergency management director.
Local government prepares for everyday emergencies, said Kates. However, during a disaster, the number and scope of incidents can overwhelm conventional emergency services, he explained. The CERT program allows members of the community to have a better understanding of what to do in an emergency, said Martuscello.
Participants will learn how to check on neighbors when the electricity goes out, how to handle downed power lines, what to do in a search and rescue incident before police or fire crews arrive, and how to properly calm an injured individual before first responders are on the scene, she said.
"We are not teaching people how to become a paramedic or firefighter, but we are teaching them basic skills to handle stressful situations before first responders arrive," she added.
One class will take place every Tuesday and Thursday from 6:30 to 8 p.m., March 21 to April 30, at Daniel Webster College, in addition to one class on Saturday, May 4, from 8:45 a.m. to 5 p.m.
The second class is scheduled from 8:45 a.m. to 5 p.m. on April 20, April 27 and May 4 at the Lake Street Fire Station.
To sign up for either course, visit www.nashuanh.gov/EMvolunteer, or call 589-3260. More classes will be scheduled in the future, and a waiting list will be formed if necessary.
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Jury acquits Mont Vernon driver, who was checking text, in death of former Amherst fire chief
Offend someone? To jail with you!
Obama to illegals: Come out of shadows
Driver acquitted in Amherst ex-chief's death
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College Hockey: Providence blanks UNH


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Products & ServicesSee also: Categories | Featured Products | Technical Articles | More Information
Description: Inspect - Record Sounds - Store Information - Manage Data The Ultraprobe 10,000 brings Ultrasound Inspection technology to a whole new level. With this one system, inspectors can perform condition analysis, record sounds, store and manage data.
- Instrument Type: Acoustic Emission, Condition Monitor / Fault Detector, Flaw Detector
- Form Factor: Portable / Hand Held / Mobile
- Air / Structure Borne: Yes
Description: The Nortec 2000D+ offers a frequency range of 50 Hz to 12 MHz for applications ranging from detection of cracks in tubes or structures to the discovery of minute flaws in aircraft materials. Single or dual frequency operation, easy to use digital conductivity, and rotating scanner support make
- Instrument Type: Flaw Detector, Corrosion Instrument, Material Condition Tester
- Form Factor: Portable / Hand Held / Mobile
Description: The Nortec 500 Series, Olympus' newest eddy current flaw detectors incorporate a full range of features: internal balance coils, VGA output connector (for heads up displays, monitors, and projectors), and a USB interface for rapid information transfer. The Nortec 500 also includes PowerLink™,
- Instrument Type: Flaw Detector
- Form Factor: Portable / Hand Held / Mobile
Description: features as well as specialized options to meet your inspection needs. Ultrasonic flaw detection is widely used for locating and sizing hidden cracks, voids, disbonds, and similar discontinuities in welds, forgings, billets, axles, shafts, tanks and pressure vessels, turbines, and structural
- Instrument Type: Thickness Gauge, Flaw Detector
- Form Factor: Portable / Hand Held / Mobile
Description: The WeldROVER is a simple, industrial-strength, one-axis encoded scanner that provides the customer with a fully mechanized automated data acquisition. It is designed to make fast and efficient phased array inspections on ferromagnetic piping or vessel girth welds and long seams with minimum
- Instrument Type: Flaw Detector
- Form Factor: Portable / Hand Held / Mobile
- Digital Imaging System: Yes
Supplier: Nex Flow Air Products Corp.
Description: The Flex.US Ultrasonic Leak Detector is a hand held, high quality compressed air leak detection system that has all the features necessary for flexible use in finding costly air leaks. The FLEX.US ultrasonic leak detector kit comes with the FLEX.US unit, carrying case, and manual and utilizes two
- Instrument Type: Acoustic Emission, Flaw Detector, Leak Detector
- Form Factor: Portable / Hand Held / Mobile
Description: The SONOSCAN vertical probes for non-destructive testing (NDT) have been specifically designed for the testing of mainly metals and plastics for the smallest of material defects. The probes can be used, for example, for the detection of fusion defects in soldered joints, welding defects, cracks
- Instrument Type: Condition Monitor / Fault Detector
- Form Factor: Portable / Hand Held / Mobile
Ultrasonic Instruments - Sensor With Integrated Data Logger For Precise Wall Thickness Measurement -- SONOWALL 50
Description: The light and compact ultrasonic wall thickness gauge SONOWALL 50 enables the precise measurement of the wall thickness of components made of metal, glass, ceramics and plastics. This efficient device allows the measurement of materials with both flat and curved surfaces. The wall thickness gauge
- Instrument Type: Thickness Gauge
- Form Factor: Portable / Hand Held / Mobile
Supplier: Cygnus Instruments, Inc.
Description: The Cygnus 3 Data Logger is versatile and easy to program with simple menu operation. Five separate formats are used to collect measurements and provide solutions to recording various geometries such as tanks, cylinders, pipes and structures.
- Instrument Type: Thickness Gauge, Flaw Detector, Corrosion Instrument
- Form Factor: Portable / Hand Held / Mobile
Supplier: ClampOn, Inc.
Description: No Description Provided
- Instrument Type: Thickness Gauge, Flaw Detector, Corrosion Instrument
- Form Factor: Monitoring System
Supplier: SICK
Description: Detection of labels - whether transparent, opaque or printed Unaffected by metallised colours Accurate detection through stable response time Small, industry-standard housing
- Instrument Type: Other
- Form Factor: Portable / Hand Held / Mobile
Supplier: Benchmark Maintenance Services, Inc.
Description: cylinders etc. Two permanent sensors, offers a wide range of detection (sonic to ultrasonic). Small compact and portable, runs on 9 volt battery, comes with beltpack. LED bargraph and alphanumeric displays with Peak Hold. High technology reduces cost! This new patented detector offers advanced
Supplier: Spectral Dynamics, Inc.
Description: P.I.N.D. - Particle Impact Noise Detection Vibration Shock and Acoustics to insure the highest of reliability For over thirty years the PIND Products Group of SPECTRAL DYNAMICS, INC. has given users a simple, reliable, and inexpensive method of Particle Impact Noise Detection (PIND) testing
- Form Factor: Bench / Rack / Cabinet
Supplier: Centurion NDT
Description: The Centurion NDT PS-710B Pulse Ultrasonic Test Unit provides versatile flaw detection capability for many inspection needs. Its state-of-the-art performance and high reliability under critical inspection conditions are depended on by many nuclear ISI inspection teams. It's also widely used
- Instrument Type: Flaw Detectors
Supplier: Polytec, Inc.
Description: noise in a bandwidth of3.2 MHz at 10 m/s maximum velocity. A wide range of options like an integrated video camera, an ultrasonic integrator and microscope objectives define the CLV-2534 as an ideal tool for R&D work on microstructures to industrial applications on large objects. With its 1.5 µm
- Instrument Type: Flaw Detectors
- Technology: Optical / Laser
- Form Factor: Bench / Rack / Cabinet
- Flaw Detection / Inspection Area: Debonding / Bond Integrity, Manufacturing - Metals / Web, Subsurface Crack Detection, Surface Cracks / Abrasion, Other
Description: Designed for ease of use, it often takes no more than 15 minutes to become competent in testing with the ULTRAPROBE® 2000 Kit Complete. Fast accurate diagnosis through the ULTRAPROBE 2000 System will dramatically reduce unplanned down time and shorten planned outage time. The ULTRAPROBE is the
- Leak Test Method: Ultrasonic Leak Detector
- Output Options: Analog Voltage
- Local Interface: Analog Front Panel
- Display Type: Analog Meter or Indicator
Description: All the advantages of Digital with the feel of Analog The Ultraprobe 9000 Kit Complete is a digital ultrasonic inspection, information storage and retrieval system that is so versatile, so easy (most operators are able to use the Ultraprobe 9000 within 15 minutes) and so much fun to operate, you'll
- Leak Test Method: Ultrasonic Leak Detector
- Output Options: Frequency / Modulated Frequency
- Local Interface: Analog Front Panel
- Computer Interface: Yes
Leak Testing Equipment - Adjustable Ultrasonic Transmitter For The Reliable Detection Of Leak -- SONAPHONE T
Description: The SONAPHONE T mobile ultrasonic transmitter is designed for the rapid and reliable detection of seal failures in windows, doors, cabins, vehicles and containers with sealing surfaces or rubber profile seals. In addition to applications in road and rail vehicle construction, the SONAPHONE T
- Leak Test Method: Ultrasonic Leak Detector
- Local Interface: Digital Front Panel
- Display Type: Digital Readouts
Ultrasonic Linear Position Sensors and Switches - Ultrasonic Sensor For The Detection Of Levels Within Pressure Accumulators And Hydraulic Cylinders -- SONOCONTROL 14
Description: The intelligent compact sensor SONOCONTROL 14 is designed for the detection of the position of pistons in hydraulic cylinders or pressure accumulators and for the monitoring of fluid levels. The sensor enable contactless measurement through the wall of a pipe or tank and is in particular suitable
- Sampling Frequency: 155 Hz
- Output: Switched / Alarm
- Interface: Serial
Standards and Technical Documents - Titanium pipes and tubes -- Non-destructive testing -- Part 2: Ultrasonic testing for the detection of longitudinal imperfections -- ISO 25902-2:2010
Description: ISO 25902-2:2010 specifies an ultrasonic testing method for detecting longitudinal imperfections in titanium seamless tubes or welded tubes. ISO 25902-2:2010 also applies to titanium alloy tubes.
Supplier: Siemens Process Instrumentation
Description: Overview The Pointek ULS200 is an ultrasonic non-contacting switch with two switch points for level detection of bulk solids, liquids and slurries in a wide variety of industries; ideal for sticky materials. Benefits 2 switch outputs for high-high, high, low and low-low level alarms or pump up
- Media Type: Liquid, Dry Material (Bulk Solids and Powders)
- Level Measurement Type: Continuous Level
- Device Classification: Sensor-Only
- Measuring Range: 9.6 to 197 inch
Standards and Technical Documents - Detection of the Error Generated by a Single Elbow on an Ultrasonic Flow Meter - ETCON 2002
Description: Ultrasonic flow meters are accurate and non-intrusive. However, one of their drawbacks is their sensitivity to installation effects especially when elbows or pulsating flows are found in front of themeterâ€s inlet. Depending on the flow rate, such installations can create perturbations
Supplier: IHS Product Design
Description: METHODS FOR ULTRASONIC DETECTION OF IMPERFECTIONS IN STEEL FORGINGS
Description: Instructor's Guide for the Instrument Technology Training Program videotape entitled Sensor and Transducer Principles. The following is covered:Sensors - RTD, Thermocouple, and Optical Pyrometer Operation; Elastic Pressure and Piezoelectric Sensor Operation; Ultrasonic Level Detection; Rotary
Description: Magnetically mounted contact probe with cable for testing consistency and for hard to reach test points. Must be used with remote access module (RAM) shown below.
- Application: NDT - Flaw / Crack Detection
Standards and Technical Documents - Electrical insulating materials and systems - Electrical measurement of partial discharges (PD) under short rise time and repetitive voltage impulses -- IEC TS 61934:2006
Description: , such as motors. Excluded are - methods based on optical or ultrasonic PD detection, - fields of application for PD measurements when stressed by non-repetitive impulse voltages.
Supplier: Megger
Description: while the operator remains at a safe distance.The ultrasonic detection system shown above consists of the instrument with indicator and speaker, plug-in ultrasonic transducer probe, directional pickup horn attachment, sound concentrator attachment and a headset. A carrying case is included.
- Form Factor: Handheld
- Bandwidth: 35000 to 45000 Hz
- Features: Battery Powered
Description: HIGHLY RELIABLE COST EFFECTIVE TESTING AT THE SPEED OF SOUND DS-386 SERIES REAL-TIME LEAK DETECTION SYSTEM CONTINUOUS ON-LINE ULTRASONIC MONITORING FOR QA INSPECTIONS FAST RESPONSE REAL-TIME TESTING HIGH VOLUME TESTING CHOICE OF TEST MODES: GROSS OR FINE UNIQUE MODULAR SENSITIVITY VALIDATION
- Leak Test Method: Ultrasonic Leak Detector
- Output Options: Analog Voltage, Analog Current, Switch or Alarm Signal
- Audible Alarm Option: Yes
Supplier: Aerospace Industries Association
Description: This Standard defines minimum requirements for the detection and evaluation of internal discontinuities in wrought metals by ultrasonic inspection and defines acceptability of parts and materials.
Description: The UWC doubles the detection range of standard scanning modules and pinpoints ultrasonic leaks & electric emissions at great distances.
- Application: General Purpose
Standards and Technical Documents - API RESEARCH REPORT - PROJECT #1114-5 ULTRASONIC TESTING REQUIREMENTS FOR SINGLE-SIDED BUTT WELDS IN OFFSHORE FABRICATIONS -- API REPORT 1114-5Supplier: American Petroleum Institute (API)
Description: of ultrasonic detection and classification trials took place using TWI's P-scan system. - These data were analysed so that the relative merits of each technique could be compared and absolute amplitude threshold information could be extracted. - A number of recommendations have been made. Principal
Supplier: General Monitors, Inc.
Description: The Gassonic Surveyor detects gas leaks by sensing the airborne ultrasound emitted from leaking gas at high pressure. Ultrasonic gas detection is based on robust and proven microphone technology and designed for long and failsafe operation in extreme environmental conditions. Because the Gassonic
- Number of Gases Sensed: Single Gas, Multi Gas
- Measurement Type: Leakage
- General Gas Types: Toxic Gas, Combustible Gas
- Specific Gas Types: Oxygen (O2), Other, Carbon Dioxide (CO2), Chlorine (Cl2), Hydrocarbons, Hydrogen (H2), Hydrogen Sulfide (H2S), Methane (CH4) / Natural Gas
Description: V391-SU Larger element diameter increases near field length
- Application: NDT - Flaw / Crack Detection
- Style / Type: Immersible / Waterproof
Description: transducer and analog or digital oscilloscope, Panametrics pulser-receivers provide the perfect starting point for ultrasonic flaw detection, thickness gaging, materials characterization, and transducer characterization.
- Form Factor: Bench
- Pulse Repetition Frequency (PRF): 200 to 10000 Hz
- Voltage Gain Range: 0.0 to 39 dB
- High Pass Filters: Yes
Supplier: Measurement Specialties, Inc.
Description: involving fluids. Ultrasonic Fluid Level Detection sensors will accurately detect the presence of liquid vs. air without being affected by the optical or dielectric properties of the liquid or its container. SL-630 sensors have integral circuitry for added ease of integration. Features: High/low liquid
- Media Type: Liquid
- Level Measurement Type: Point Level / Multi-Point Levels
- Device Classification: Sensor-Only
- Meter Technology: Ultrasonic / Sonic
Find Suppliers by Category Top
Featured Products Top
SONOTEC Ultraschallsensorik Halle GmbH
Ultrasonic Leak Detector SONAPHONE M
The SONAPHONE M is designed for the rapid, reliable and cost-effective detection of seal failures and the smallest of leaks within compressed air systems and networks, vacuum systems, industrial equipment and machinery and covered pipes with restricted access. The ultrasonic detection device enables the early detection and avoidance of potential damages and resulting cost savings. The regular inspection of engines, pumps and gearing using the SONAPHONE M leads to increased operational... (read more)
Browse Nondestructive Testing (NDT) Equipment Datasheets for SONOTEC Ultraschallsensorik Halle GmbH
Olympus Scientific Solutions America
Ultrasonic Flaw Detection Tutorial
The Ultrasonic Flaw Detection Tutorial covers conventional ultrasonic flaw detection. A closely related technique, phased array inspection, is discussed in our Phased Array Tutorial. Another NDT technique for flaw detection is eddy current testing, discussed in our introduction to Eddy Current and Eddy Current Array Tutorial. This self-guided tutorial provides a basic introduction to ultrasonic flaw detection, both for newcomers and for experienced users who want a review of basic... (read more)
Browse Flaw Detectors Datasheets for Olympus Scientific Solutions America
Rosemount Analytical
Emerson Ultrasonic Gas Leak Detection
Ideally suited for monitoring well ventilated outdoor environments, the GDU-Incus has been engineered to withstand even the most extreme conditions while including features designed to optimize performance and reduce maintenance. Ultrasonic (acoustic) gas leak detection technology has several advantages over conventional gas sensor technologies: it does not have to wait until a gas concentration has accumulated to potentially dangerous concentrations, it does not require a gas cloud... (read more)
Browse Gas Sensors Datasheets for Rosemount Analytical
MSA - The Safety Company
Gassonic Observer-i Ultrasonic Gas Leak Detection
Designed with Artificial Neural Network (ANN) intelligence and real-time broadband acoustic sound processing technology, the state-of-the-art Gassonic Observer-i Ultrasonic Gas Leak Detector sets a new global industry standard in highly reliable ultrasonic gas leak detection with unprecedented suppression of false alarms. With the incorporation of ANN technology, the breakthrough Gassonic Observer-i Detector makes it possible to fully analyze the sound spectrum above 12 kHz. The ANN... (read more)
Browse Leak Testing Equipment Datasheets for MSA - The Safety Company
Baumer Ltd.
Ultrasonic Sensor for Harsh Environments
New Ultrasonic Sensor Family Provides Long-Range Measurement and Proximity Sensing for Harsh Environments. Baumer 's New Series 70 Ultrasonic Sensors Provide Sensing Range up to 6 Meters. The new Series 70 ultrasonic sensor family from Baumer adds new features to proven technology to solve very demanding applications in the Food & Beverage, Logistics, Packaging, and Printing & Graphics markets. With a 6-meter detection range, ultra-slim sonic cone only more than 50% smaller... (read more)
Browse Ultrasonic Proximity Sensors Datasheets for Baumer Ltd.
Danatronics Corporation
iFlaw™ Digital Ultrasonic Flaw Detector!
Danatronics is pleased to announce the introduction of our new digital ultrasonic flaw detector, iflaw ™. This product represents a break through in portable ultrasonic flaw detection. iflaw ™ is the first ever, completely touch screen digital, ultrasonic flaw detector with a 7" sunlight readable, wide VGA display that can rotate the image automatically from landscape to portrait modes. iflaw ™ is designed to meet IP67 environmental standards and engineered with a custom, high... (read more)
Browse Ultrasonic Instruments Datasheets for Danatronics Corporation
General Monitors, Inc.
Ultrasonic Gas Leak Detector Handbook
Process, safety and plant engineers responsible for gas leak detection will find that the Gassonic Technical Handbook from General Monitors explains how to incorporate ultrasonic gas leak detectors into plant fire and gas (F &G) detection systems. This handbook provides engineers with valuable "how to" information useful when integrating ultrasonic gas leak detectors into new oil and gas installations or when retrofitting existing facilities. The handbook presents... (read more)
Browse Gas Sensors Datasheets for General Monitors, Inc.
Olympus Scientific Solutions America
Ultrasonic Detector with Phased Array Imaging
The EPOCH 1000 Series Digital Ultrasonic Flaw Detectors combines the highest level of performance for conventional portable flaw detection with the power of phased array imaging. The EPOCH 1000, 1000iR and 1000i feature a new horizontal case style with full VGA display, knob and navigation arrows for parameter adjustment, and full EN12668?1 compliance. The advanced conventional ultrasonic functionality of the EPOCH 1000 series is augmented in the EPOCH 1000i with phased array imaging... (read more)
Browse Flaw Detectors Datasheets for Olympus Scientific Solutions America
Olympus Scientific Solutions America
Handheld 45MG Ultrasonic Thickness Gage
measurements of internally corroded pipes using dual element probes to very precise thickness measurements of thin materials using single element transducers. Ultrasonic thickness measurements are accurate, reliable, and repeatable. Instant readings can be achieved from one side of a material, making destruction of the part unnecessary. The 45MG boasts powerful standard thickness measurement features and specialized software options. For corrosion detection applications, the gage offers optional... (read more)
Browse Thickness Gages Datasheets for Olympus Scientific Solutions America
MSA - The Safety Company
UltraSonic® EX-5 Features Wide Range
in temperatures ranging from -40 °F to 140 °F (-40 °C to 60 °C), making it suitable for use in a variety of environmental conditions. MSA is the world leader in fixed gas and flame detection. For additional information on the UltraSonic EX-5 Gas Leak Detector, view: Product Information. Bulletin #07-8303-MC. To learn more about MSA products visit: www.MSAsafety.com... (read more)
Browse Gas Instruments Datasheets for MSA - The Safety Company
Conduct Research Top
Ultrasonic Detection of Surface Flaws in Sintered Alpha Silicon Carbide (.pdf)
It is well recognized that surface and near-surface flaws control the strength of the majority of specimens from a population of sintered alpha-carbide test bars. An investigation was carried out to examine the applicability of surface acoustic wave techniques (SAW) to detect two-dimensional
Ultrasonic Gas Leak Detection - What is it and How Does it Work?
Ultrasonic gas leak detection (UGLD) is a comparatively recent detection technique and has emerged as an effective means of establishing. the presence of gas leaks. It works especially well in open, ventilated areas where other methods of gas detection may not be independent. of ventilation
Implementing Ultrasonic Ranging
Object ranging is essential in many types of systems. One of the most popular ranging techniques is ultrasonic ranging. Ultrasonic ranging is used in a wide variety of applications including: ? Autofocus cameras ? Motion detection ? Robotics guidance ? Proximity sensing ? Object ranging
Notes for Ultrasonic Sensor Applications
The key to ultrasonic liquid detection is to keep the beam perpendicular to the liquid level and away from structures like tank walls, internal ladders, and impellers. If ordering a USR Series model with a tri clamp, remember that a ferrule has to be welded to the vessel's top in
Acoustic / Ultrasonic Transducers
Ultrasonic transducers send and receive waves for many types of sensing. Distance, proximity, level, nondestructive evaluation, web break detection, counting, and security applications are some examples. Ultrasonic transducers typically operate at their resonant frequency with various construction
Ultrasonic Sensors, The Silent Laborers
away, outside the set detection range; in this particular instance the delay time "sensor - object - sensor" was too long. As a result ultrasonic sensors are also excellent background fade-out units; in addition - if compared to other optical units with comparable characteristics
Use of a PC-Based Digitizer in an Ultrasonic Flaw-Detection System
Use of modern high-speed digitizers in the construction of an ultrasonic flaw detection system is discussed. Topics include the advantages of high sampling speed, high vertical resolution, deep acquisition memory buffers, and fast data transfer speed to the host PC. Issues that arise due
Sensor Sense: Ultrasonic Double-Sheet Detectors
on the machine. Those surfaces may need a layer of sound-absorbing material. Other applications for these sensors include ultrasonic splice detection that senses a
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A control system of mobile navigation robot for precise spraying based ultrasonic detecting and ARM embedded technologies
A control system of mobile navigation robot for precise spraying based ultrasonic detecting and ARM embedded technologies .
52\nFigure 18 Ultrasonic Detection Alarm Units ............................................................................
Acoustics of Wood
Station Qualit' des Bois, INRA, Centre de Recherches Forestières de Nancy Bucur V, Janin G, Herbe C, Ory JM (1991) Ultrasonic detection of reaction wood in European species.
Advanced NXT
NXT-G ultrasonic detection .
Natural Gas Hydrates
Acoustic techniques used in laboratories are now mainly classified into two categories: ultrasonic detection and the piezoceramic bender element and resonant column test technique.
Nondestructive Testing of Materials and Structures
Unlike macro-delaminations, the ultrasonic detection of micro-delamination zone has proven more challenging.
Ultimate sensitivity of time-resolved optoacoustic detection
Thus, wide band detectors in which the upper limit of the ultrasonic detection band exceeds the lower limit more than 10 times are required for correct opto-acoustic detection of laser-induced acoustic sources.
Proceedings of the specialists' meet- ing on acoustic/ ultrasonic detection of in sodium water ieal(s on steam generators, held in Aix-en-Provence, France, 1-3 October 1990.


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We spent the night at Becky's before picking up our children at a nearby camp. It's not your typical old farmhouse B&B, quite modern, including cable TV. Becky is very warm and welcoming, the house was very clean, and our stay was quite comfortable.
We spent the night at Becky's before picking up our children at a nearby camp. It's not your typical old farmhouse B&B, quite modern, including cable TV. Becky is very warm and welcoming, the house was very clean, and our stay was quite comfortable.
My wife and I stayed at Becky's during parent's weekend at my daughter's nearby camp. Given the supply and demand for rooms on these weekends, for first timers, it's a bit daunting and a lot like rolling the dice. Fortunately Becky was a gracious, accessible host. She was very attentive to our request for a larger bed, and while she... More
Becky is the most amazing hostess and her bed and breakfast is more than one can imagine. I was traveling with my older family members and wanted the trip to be special and comfortable for them. Becky had a fire already going and greeted us with tea and fresh made ginger snap cookies. I felt like I was in a... More
We stayed at Becky's B&B this past weekend for one night. We were visiting our eldest son at his boarding school. We checked our luggage at Becky's a little earlier than was expected, but she was willing to take our luggage and show us around her B&B. When we came back from visiting our son, we relaxed in her spacious... More
We have been staying at Becky's for 6 years. She has a variety of rooms and always makes us a great breakfast. 10 times more accommodating than a bed and breakfast!
I loved my over night stay At Becky's. sitting fireside in front of the Tv while working on my computer made me feel very much at home- as did the tasty breakfast and comfortable bed. Well worth the reasonable cost
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Ok, will attach a poll to this thread about who decides on the themes for SOTW. By the way, feel free to PM me if you want to see certain themes used. I'm all ears.
Thanks for your nice comments Ky-lyrra.
So fair these wild west sigs are looking very good.


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Nearly Ninth Inning For Microsoft Smartphone Effort
Pardon the baseball metaphor but it seemed appropriate: the impending debut of Windows Phones (Windows Mobile 7) is a very high stakes moment for Microsoft, especially in the wake of Kin's recent failure. Redmond is now poised to spend a great deal of money to promote the new mobile OS in a highly competitive environment with little guarantee of success.
If consumers and enterprises "take" to it Microsoft will be back in the mobile game. If not Microsoft may be shut out of a critical market (smartphones) for at least the foreseeable future. That would then probably require some hard-to-imagine radical moves — because within the next decade (or sooner) more Internet access will happen on mobile devices than on PCs.
The fate of Windows Phones and Bing's future are not necessarily inextricably linked. Bing has diversified beyond Windows Mobile and can succeed potentially even if Windows Phones fail. But it needs to succeed on its own merits rather than count on default search deals like the one with Verizon (which has seen some user backlash).
So far it the forthcoming Windows Phone OS, which will debut on multiple handsets, has received one generally positive, if mixed early review. My hunch is that this will be the tone of other reviews to come.
I would like to see Microsoft succeed and offer a competitive OS and user experience. A more competitive market is good for consumers and accelerates product development across the board. Witness the iPhone's (and later Android's) impact on the smartphone market. A formerly sleepy segment became, in the course of two years, the hottest part of the handset market and essentially gave birth to the mobile internet.
A recent smartphone forecast from Gartner, however, assumes that Microsoft will not make any gains in the smartphone segment and will see further diminishing share:
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(Some images used under license from Shutterstock.com.)
The best news in mobile marketing every Thursday.


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Find Free WiFi Hotspots
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Holiday Inn Paris Montparnasse
(Free Wifi Hotel / Motel / Resort)
10 Rue Gager-Gabillot
Paris, France, 75015
01 44 19 29 29
Holiday Inn Paris Montparnasse is a free wifi hotel / motel / resort located in Paris Ile-De-France.
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7 Comments about Holiday Inn Paris Montparnasse
Enjoyed our weekend break in this hotel! After a 5/10 min. walk you are at the closest metro station, from there it takes you about 15/20 min. to be i
- tripadvisor.com
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Hard to find, street is not on your generic tourist map. Hotel is out of the way. It is in a residential area, with offices close by. Also the hotel i
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Nice Hotel, staff spoke 5 languages, close to subway stations, had to get use to twin beds, food was fair, go to a restaurant...
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Our stay in Paris came at the end of our whirlwind France tour. We had stayed there earlier at the Novotel before moving on to Lyon. So we knew what w
- tripadvisor.com
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This was our second stay here (and my second review of this hotel). This hotel has a sort of charm you don't usually find in large Holiday Inn's. An
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We booked this hotel using points, and were very glad with our choice. Clean, nicely appointed rooms, very friendly and helpful staff, close to the un
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We stayed here for four days and found the hotel ideal for our stay in Paris. Metro stations within easy reach made travel to/from the city centre rel
- tripadvisor.com
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ICT Support Technician
Salary £17,000 – £23,000 depending on qualifications and experience
We are a growing company based in Northamptonshire, providing technical support and services to the education sector.
We are looking for a dynamic, enthusiastic and customer focused individual with experience in IT support, preferably within the school environment, to provide technical support to our growing customer base. The role is for a field based technician, mainly travelling each day to one or two schools within the Northamptonshire area.
Ideal candidate will need:
- A solid understanding of MS Windows Server 2003/2008/2012 networks.
- A high degree of knowledge of desktop operating systems (Windows 7/8, Apple iOS).
- Experience in the installation and configuration of new desktops or laptops.
- Experience in MS Office 2003 – 2013 installation & administration.
- Preferably at least 1 year minimum experience supporting IT within a school environment.
- Experience in installing and maintaining SIMS/FMS.
- Good hardware, software, printing and networking troubleshooting skills.
- Experience in supporting RM products.
- Great interpersonal skills, and able to organise themselves and their time effectively.
- A 'can-do' attitude and be willing to work as part of a team.
- A full, clean driving license.
The successful candidate will join a team of exceptional technicians in a business with an outstanding reputation in quality of service. The position has excellent opportunities for career progression and is subject to the candidate passing an enhanced DBS check.
Please email your CV and covering letter to email@example.com
Last edited by Dos_Box; 11th June 2014 at 04:38 PM. Reason: Authorised
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MVC Widget Error
7 Tips to Prepare for Your Appointment
The key to a successful appointment is communication. To get the most out of your visit, prepare ahead of time so you can lead the conversation with your doctor. These 7 tips will get you ready
Appointments & Offices
Check insurance plans, locations and make an appointment
Is Dr. Aquiler accepting new patients?
- Yes.
Office Locations
- Rosemary M Aquiler MD
- 33466 W 8 Mile Rd Ste 168
- Farmington Hills, MI 48335
- (248) 426-0110 (Office)


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You look very Bruce Campbell ala Old Spice. (That's a compliment, BTW)
Oooooooo.... I need an ascot! That would be a great addition to my brewing wardrobe (J/K) sorry
OMFG, it's his smoking jacket. I don't know why I didn't think of that earlier....
(I have a courdoroy sportcoat that I wear all the time... just not when I'm making beer ).
My stout has had some aging, and it's in the process of carbing in the keg right now. No noticeable smoke flavor from smoking 1/4 of the grain bill. Fuggit, next time I'm smoking it all.
Make Beer, Not War.
Cool, thanks for the update mckbrew. Now, I tried smoking some malt, but I had problems trying to keep the grains in the bowl.
There is a very fine line between "hobby" and "mental illness."
I realize this thread is very old, but have just gone through the process of smoking grains, and have some questions.
I am brewing an Imperial Stout, and the original plan was to smoke all of the base malt for about 30 min. I made up some SS mesh baskets, and used a friends Little Chief smoker with apple and cherry wood. I wet the grains with a spray bottle, and turned the grain every 10 min, at the 30 min mark, the grain had no noticeable smoke aroma, so I continued to wet it and smoke it for another hour and a half. The grain is now really smoky, and I am considering using it for 50% of my base malt. If I chew up a grain, it absolutely tastes like smoke. This is going to be a big assertive beer, and I dont want the smoke to be lost, but I also dont want a total smoke bomb.
Those of you who have smoked your own grain, how noticeable was the smoke aroma / flavor in the raw grain, how much of it did you go with in the beer, and how noticeable was it in the finished product?
I realize that predicting the results are impossible, but I just want a few data points to base my decision on.
My HERM electric build: http://www.homebrewtalk.com/f170/mas...rewery-266056/
I haven't brewed in awhile, nor can I remember exactly what I used in this recipe but it was nowhere near 50 percent base malt and it was so smokey after several months that I poured it.
A few years ago I used a porter recipe from my lhbs and smoked 30% of my grain. I put it in aluminum bbq pans and stirred it maybe four times before I got distracted with company. I accidentally smoked it for just over 2 hours. I did wet the crushed grain before smoking and I went directly from the smoker to the mash tun with the grain. During brewing and fermentation there was a strong smoke smell comming from the kettle and brew bucket. After kegging the smoke was too strong to drink. Probably a 3 week primary then kegged. I pulled that keg and left at room temp and tasted every other weekish and after maybe 3 months the smoke mellowed and it tasted greate.


text:
November 27, 2014
Posted: Tuesday, May 8, 2012 --- 5:00p.m.
CHIPPEWA FALLS, Wis. (AP) -- An argument over Wisconsin's recall primaries has landed a Chippewa Falls husband in the hospital.
Chippewa Falls police say 36-year-old Jeffrey A. Radle and 30-year-old Amanda M. Radle argued Tuesday over the ongoing recall primaries.
As Amanda tried to leave, police say Jeffrey stood in front of her vehicle to prevent her from going.
A Chippewa Herald report (http://bit.ly/IXtXFo ) says Amanda repeatedly nudged him with the vehicle but he stood his ground. When she tried to drive around him, he allegedly jumped in front of the vehicle and was struck.
Amanda reported the incident to police. Jeffrey Radle's condition wasn't immediately available.
Both are being referred to the district attorney for possible domestic-related charges.
A man who answered the phone at the Radle home says no one was available to comment.
Information from: The Chippewa Herald, http://www.chippewa.com
Copyright 2012. The Associated Press.
Click Here to access the online Public Inspection File
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5 Units (Min. Order)
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Linear Weighfil 8 x Packaging Machinery 1 High Quality 2 At reasonable price 3 On time Delivery.
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Trade Alerts are FREE updates on topics such as trending hot products, buying requests and supplier information - sent directly to your email inbox!


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Comments on Storytelling in the 2800
View Single Post
Archived Post
Lt. Commander
Join Date: Dec 2007
Posts: 120
# 18
Originally Posted by
One of the big plot holes for me was at "Of Bajor", when talking with Loriss.
She's the commander of a huge Dominion fleet, yet she's so stupid that she can't check her ship's clock with the station's to see that 20 years have passed? Nor do quantum dating (which seems fairly common in Star Trek), to once again, see her and her fleet suffered a 20 years time lapse? Nor can she somehow send *just one* ship back to the Gamma Quadrant to ask "Hey, did this war end by any chance?"? Really?
This feeds back into the whole "teenage drama queen" thing that a lot of Vorta seem to have going on - utterly unwilling to admit ANY evidence that would undermine their position.


text:
NOAA Commissioned Officer Corps
NOAA Commissioned Officer Corps Jobs & Careers
1 NOAA Commissioned Officer Corps jobs found on Monster.Jobs 1 to 1 of 1
NOAA Commissioned Officer Corps Seattle, WA
IT'S MORE THAN A DESK JOB! If you are a graduate of a four-year college or university and are interested in a career that includes service to your country, science, and adventure, you will find a unique opportunity in the NOAA Commissioned Officer Corps (NOAA Corps). The NOAA Corps is the uniformed component of the National Oceanic and Atmospheric Administration, a Bureau of the Department of Com...
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Online dating brings singles together who may never otherwise meet. It's a big world and the PetPeopleMeet.com community wants to help you connect with singles in your area. Whether you are seeking just a date, a pen pal, a casual or a serious relationship, you can meet singles in Colorado Springs today! Colorado is known for its rugged beauty and PetPeopleMeet.com is here to bring their Pet People Singles together.Search Single Pet People Men in Colorado Springs | Search Single Pet People Women in Colorado Springs
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Groupon offers the factory-refurbished Escort Passport 8500 X50 Radar / Laser Detector in Blue, model no. 8500-X50, for $149.99 with free shipping. That's $40 under our mention of different color from two weeks ago and the lowest total price we could find now by $136. It features reprogrammable digital signal processing and AutoSensitivity.
A 6-month Escort warranty applies.
Update: Apply coupon code "10FORU" to drop it to $139.99.
$140 + free shippingSHOP NOW
Refurb Escort Passport 8500 Radar / Laser Detector
Posted September 24, 2014


text:
Cuisinart Soft Serve Ice Cream Maker
Professional-quality soft ice cream, yogurt, sorbet and sherbet are now available right at home, with the Cuisinart Mix It In Soft Serve Ice Cream Maker. Not only does it make everyones favorites, but with three built-in condiment dispensers, it makes them extra delightful! Just a pull of a tab sends sprinkles, chips and other mix-ins down the chute to mix right into frozen desserts as cones or bowls are filled. The operation is fully automatic; simply pour in the ingredients and turn the dial.
Source: Fancycrave.com
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An FYI for anyone working this line: John Long Routt, first territorial governor of Colorado, was an uncle of Sarah Bay (daughter of James Simpson Bay -m- Sally Routt). Sarah married an Edward S. (Ned) Walker in 1866 at McLean County, Illinois. Walker was a brother of David Davis Walker, who was a gg-grandfather of the current President GWBush.
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