text:
Kalirin-7 is required for synaptic structure and function.
ABSTRACT Rho GTPases activated by GDP/GTP exchange factors (GEFs) play key roles in the developing and adult nervous system. Kalirin-7 (Kal7), the predominant adult splice form of the multifunctional Kalirin RhoGEF, includes a PDZ [postsynaptic density-95 (PSD-95)/Discs large (Dlg)/zona occludens-1 (ZO-1)] binding domain and localizes to the postsynaptic side of excitatory synapses. In vitro studies demonstrated that overexpression of Kal7 increased dendritic spine density, whereas reduced expression of endogenous Kal7 decreased spine density. To evaluate the role of Kal7 in vivo, mice lacking the terminal exon unique to Kal7 were created. Mice lacking both copies of the Kal7 exon (Kal7(KO)) grew and reproduced normally. Golgi impregnation and electron microscopy revealed decreased hippocampal spine density in Kal7(KO) mice. Behaviorally, Kal7(KO) mice showed decreased anxiety-like behavior in the elevated zero maze and impaired acquisition of a passive avoidance task, but normal behavior in open field, object recognition, and radial arm maze tasks. Kal7(KO) mice were deficient in hippocampal long-term potentiation. Western blot analysis confirmed the absence of Kal7 and revealed compensatory increases in larger Kalirin isoforms. PSDs purified from the cortices of Kal7(KO) mice showed a deficit in Cdk5, a kinase known to phosphorylate Kal7 and play an essential role in synaptic function. The early stages of excitatory synaptic development proceeded normally in cortical neurons prepared from Kal7(KO) mice, with decreased excitatory synapses apparent only after 21 d in vitro. Expression of exogenous Kal7 in Kal7(KO) neurons rescued this deficit. Kal7 plays an essential role in synaptic structure and function, affecting a subset of cognitive processes.
Article: Postsynaptic Density Scaffold SAP102 Regulates Cortical Synapse Development through EphB and PAK Signaling Pathway.[Show abstract] [Hide abstract]
ABSTRACT: Membrane-associated guanylate kinases (MAGUKs), including SAP102, PSD-95, PSD-93, and SAP97, are scaffolding proteins for ionotropic glutamate receptors at excitatory synapses. MAGUKs play critical roles in synaptic plasticity; however, details of signaling roles for each MAGUK remain largely unknown. Here we report that SAP102 regulates cortical synapse development through the EphB and PAK signaling pathways. Using lentivirus-delivered shRNAs, we found that SAP102 and PSD-95, but not PSD-93, are necessary for excitatory synapse formation and synaptic AMPA receptor (AMPAR) localization in developing mouse cortical neurons. SAP102 knockdown (KD) increased numbers of elongated dendritic filopodia, which is often observed in mouse models and human patients with mental retardation. Further analysis revealed that SAP102 coimmunoprecipitated the receptor tyrosine kinase EphB2 and RacGEF Kalirin-7 in neonatal cortex, and SAP102 KD reduced surface expression and dendritic localization of EphB. Moreover, SAP102 KD prevented reorganization of actin filaments, synapse formation, and synaptic AMPAR trafficking in response to EphB activation triggered by its ligand ephrinB. Last, p21-activated kinases (PAKs) were downregulated in SAP102 KD neurons. These results demonstrate that SAP102 has unique roles in cortical synapse development by mediating EphB and its downstream PAK signaling pathway. Both SAP102 and PAKs are associated with X-linked mental retardation in humans; thus, synapse formation mediated by EphB/SAP102/PAK signaling in the early postnatal brain may be crucial for cognitive development.Journal of Neuroscience 03/2013; 33(11):5040-52. · 6.91 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: In the mammalian brain, the majority of excitatory synapses are housed in micron-sized dendritic protrusions called spines, which can undergo rapid changes in shape and number in response to increased or decreased synaptic activity. These dynamic alterations in dendritic spines require precise control of the actin cytoskeleton. Within spines, multidomain Rho guanine nucleotide exchange factors (Rho GEFs) coordinate activation of their target Rho GTPases by a variety of pathways. In this review, we focus on the handful of disease-related Rho GEFs (Kalirin; Trio; Tiam1; P-Rex1,2; RasGRF1,2; Collybistin) localized at synapses and known to affect electrophysiology, spine morphology, and animal behavior. The goal is to integrate structure/function studies with measurements of synaptic function and behavioral phenotypes in animal models.The Neuroscientist 02/2013; · 5.63 Impact Factor
Article: Non-enzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.[Show abstract] [Hide abstract]
ABSTRACT: Like several Rho GDP/GTP exchange factors (GEFs), Kalirin7 (Kal7) contains an N-terminal Sec14 domain and multiple spectrin repeats. A natural splice variant of Kalrn lacking the Sec14 domain and four spectrin repeats is unable to increase spine formation; our goal was to understand the function of the Sec14 and spectrin repeat domains. Kal7 lacking its Sec14 domain still increased spine formation, but the spines were short. Strikingly, Kal7 truncation mutants containing only the Sec14 domain and several spectrin repeats increased spine formation. The Sec14 domain bound phosphoinositides, a minor but crucial component of cellular membranes, and binding was increased by a phosphomimetic mutation. Expression of KalSec14-GFP in non-neuronal cells impaired receptor-mediated endocytosis, linking Kal7 to membrane trafficking. Consistent with genetic studies placing Abl, a non-receptor tyrosine kinase, and the Drosophila ortholog of Kalrn into the same signaling pathway, Abl1 phosphorylated two sites in the fourth spectrin repeat of Kalirin, increasing its sensitivity to calpain-mediated degradation. Treatment of wildtype mouse, but not Kal7(KO) mouse, cortical neurons with an Abl inhibitor caused an increase in linear spine density. Phosphorylation of multiple sites in the N-terminal Sec14/spectrin region of Kal7 may allow coordination of the many signaling pathways contributing to spine morphogenesis.Molecular biology of the cell 03/2014; · 5.98 Impact Factor
Page 1
Kalirin 7 is required for synaptic structure and function
Xin-Ming Ma*, Drew D. Kiraly*, Eric D. Gaier, Yanping Wang, Eun-Ji Kim, Eric S. Levine, Betty
A. Eipper, and Richard E. Mains‡
All authors are in the Department of Neuroscience, University of Connecticut Health Center
Rho GTPases activated by GDP/GTP exchange factors (GEFs) play key roles in the developing and
adult nervous system. Kalirin-7 (Kal7), the predominant adult splice form of the multifunctional
Kalirin RhoGEF, includes a PDZ binding domain and localizes to the postsynaptic side of excitatory
synapses. In vitro studies demonstrated that overexpression of Kal7 increased dendritic spine density
whereas reduced expression of endogenous Kal7 decreased spine density. To evaluate the role of
Kal7 in vivo, mice lacking the terminal exon unique to Kal7 were created. Mice lacking both copies
of the Kal7 exon (Kal7KO) grew and reproduced normally. Golgi impregnation and electron
microscopy revealed decreased hippocampal spine density in Kal7KO mice. Behaviorally, Kal7KO
mice showed decreased anxiety-like behavior in the elevated zero maze and impaired acquisition of
a passive avoidance task, but normal behavior in open field, object recognition and radial arm maze
tasks. Kal7KO mice were deficient in hippocampal long-term potentiation. Western blot analysis
confirmed the absence of Kal7 and revealed compensatory increases in larger Kalirin isoforms. PSDs
purified from the cortices of Kal7KO mice showed a deficit in Cdk5, a kinase known to phosphorylate
Kal7 and play an essential role in synaptic function. The early stages of excitatory synaptic
development proceeded normally in cortical neurons prepared from Kal7KO mice, with decreased
excitatory synapses apparent only after 21 days in vitro. Expression of exogenous Kal7 in Kal7KO
neurons rescued this deficit. Kal7 plays an essential role in synaptic structure and function, affecting
a subset of cognitive processes.
dendritic spine; hippocampus; Golgi method; LTP; passive avoidance; anxiety; PSD; cdk5
Alterations in the placement, prevalence and structure of dendritic spines, the site of most
glutamatergic, excitatory endings in the brain, play a critical role in the synaptic plasticity
underlying learning and memory (Yuste and Bonhoeffer, 2001;Knott et al., 2006;Craig et al.,
2006;Craig and Kang, 2007;Dunaevsky and Mason, 2003;Ehlers, 2002;Araya et al.,
2007;McAllister, 2007). Spines change in response to stimuli producing long term potentiation
or long term depression (Mezey et al., 2004;Geinisman et al., 2000). In vivo, learning tasks,
memory tasks, electroconvulsive shock and exposure to hormones, cocaine or ethanol alter
spine morphology and function (Li et al., 2004;Jelks et al., 2007;McAllister, 2007;Fukazawa
et al., 2003;Lisman and Raghavachari, 2006;Knott et al., 2006;Norrholm et al., 2003;Robinson
et al., 2001). Inherited conditions associated with mental retardation and neurologic/psychiatric
‡To whom correspondence should be addressed: Department of Neuroscience, University of Connecticut Health Center, 263 Farmington
Ave., Farmington CT 06030-3401, email@example.com, 860-679-8894 voice; -1060 fax.
*These authors contributed equally to this work.
Senior Editor: Dr. Marie Filbin
NIH Public Access
Author Manuscript
J Neurosci. Author manuscript; available in PMC 2008 November 25.
Published in final edited form as:
J Neurosci. 2008 November 19; 28(47): 12368–12382. doi:10.1523/JNEUROSCI.4269-08.2008.
NIH-PA Author Manuscript
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Page 2
abnormalities are often associated with spine abnormalities and have revealed key roles for
small GTP binding proteins of the Rho family (Meredith et al., 2000;Norrholm and Ouimet,
2000;Ramakers, 2000;Hill et al., 2006;Tabuchi et al., 2007).
Variations in spine size and shape affect signal transmission by AMPA and NMDA receptors
localized to the post-synaptic density (PSD). The PSD is a complex, 1.1 gigadalton molecular
machine, with its many components arrayed in a tightly controlled but dynamic manner;
proteomic approaches (Elias et al., 2006;Beique et al., 2006;Collins et al., 2006;Sheng and
Hoogenraad, 2007) reveal the presence of 300 copies of PSD-95 and 15 to 20 tetrameric NMDA
and AMPA receptors in the typical cortical PSD. Kalirin-7(Kal7) is the only Rho GDP/GTP
exchange factor (RhoGEF) identified in purified PSDs (Sheng and Hoogenraad, 2007;Collins
et al., 2006;Penzes et al., 2001). Cyclin dependent kinase 5 (Cdk5), a Ser/Thr kinase localized
to the PSD and known to phosphorylate several proteins critical to synaptic function (Zhang
et al., 2008;Morabito et al., 2004;Cheung and Ip, 2007;Cheung et al., 2006), also
phosphorylates Kal7, altering its effects on spine morphology (Xin et al., 2008).
Kal7 is co-localized with PSD-95, AMPA and NMDA receptors at excitatory synapses on the
dendritic spines of CA1 hippocampal pyramidal neurons and the dendritic shafts of
hippocampal GABAergic interneurons (Ma et al., 2008). Expression of Kal7 increases during
the time of maximal synaptogenesis in the hippocampus (Ma et al., 2003;Ma et al., 2008). In
vitro studies point to an important role for Kal7 in synaptic function. Exogenous Kal7 caused
spine formation in aspiny GABAergic interneurons while decreased expression of endogenous
Kal7 caused the loss of excitatory synapses (Ma et al., 2008). The interactions of Kal7 with
PDZ domain proteins such as AF-6 (Xie et al., 2008) and PSD-95 (Penzes et al., 2001), coupled
with the actions of the Sec14p, spectrin-like and GEF domains it shares with the larger isoforms
of Kalirin (Schiller et al., 2008;Schiller et al., 2005), all contribute to its actions.
Since in vitro studies do not always accurately indicate in vivo function (Chubykin et al.,
2007;Tabuchi et al., 2007;Varoqueaux et al., 2006), we engineered a mouse lacking the unique
exon that defines Kal7. Despite the existence of 69 RhoGEFs (Rossman et al., 2005), lack of
this isoform of Kalirin results in a decreased number of dendritic spines and excitatory
synapses. In addition to morphological changes, mice lacking Kal7 and ΔKal7 (Fig. 1A) exhibit
decreased anxiety-like behavior, deficits in hippocampal-dependent learning and diminished
long term potentiation. The decreased levels of Cdk5 found in PSDs purified from Kal7KO
mice may contribute to many of these deficits.
Creation of the Kal7 conditional and total null mice
The basic strategy for creation of the conditional knockout is diagramed in Fig. 1B. The Kal7
exon, which encodes the 20 amino acids unique to Kal7 and ΔKal7, is 0.9 kb in length and is
flanked by introns which are 18 kb (upstream) and 36 kb (downstream). Lox-p sites were
introduced 1.7 kb upstream (nt 34155267, mm9, July 2007) and 2.0 kb downstream of the Kal7
exon (924 nt) (nt 34150670). The neomycin resistance cassette was used in cell selection and
was removed by passage through flipper female mice (Farley et al., 2000). The conditional
knockout (Kal7CKO/+) was bred for 10 generations into C57Bl/6 females from Jackson Labs.
To remove the Kal7 exon, Kal7CKO/+ males were bred with Hprt-Cre females (Jackson #
004302) and the progeny were then bred into the C57Bl/6 background; these mice lack 4.6 kb
of chromosome 16 and retain the lox-p sequence
(ATAACTTCGTATAATGTATGCTATACGAAGTTAT; Fig. 1C). Experiments reported
here used mice back-crossed into C57Bl/6 for three to seven generations; Kal7KO/+ and
Kal7KO mice were compared to littermate controls. Screening of genomic DNA prepared from
tail snips utilized primers A (AATAAAATTACTCAAGCCACTTCCAGTC), B
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(GGACATTTGCATGACATTGAGTCTAAAG) and E (TGTTCATACAGCTGTCTGGGG)
(Fig. 1B, C). PCR conditions: 94°C, 2.5 min; 55°C,1 min; 72°C, 32 sec; 40 cycles. Products
encompassing the lox-p sites and the products of Flp and Cre recombinase were of the predicted
sizes; DNA sequence analysis of excised bands confirmed their identities. The Kal7CKO mice
were created in the University of Connecticut Gene Targeting and Transgenic Facility.
Antibodies used in these studies
Antisera described previously include polyclonal antisera to the Kalirin spectrin domain
(JH2582), Kal7 COOH-terminal end (affinity-purified JH2958; JH2959; specific for the
COOH-terminal portion of the 20 amino acid residues unique to Kal7 (Ma et al., 2008)), Kal12
COOH-terminal end (JH3225) and monoclonal antibodies to the Kal7 COOH-terminal end
(20D8; specific for the NH2-terminal portion of the 20 amino acid residues unique to Kal7),
PSD-95, and myc (Ma et al., 2008), and a polyclonal to Trio (CT233) (McPherson et al.,
2005). Commercial antibodies to bassoon, Vglut1, GluR1, GluR2, NR1, GAD65, GAD65/67,
VGAT, MAP2, and GFP were as described (Ma et al., 2008). The following commercial
antibodies were also used: synaptophysin (Clone svp-38), δ-catenin (C2989) and actin (A2066)
(Sigma, St. Louis, MO), NR2B (clone N59/20, NeuroMab, Davis, CA), Shank3 (cloneN69/46,
NeuroMab), neuroligins-1 and -2 (Synaptic Systems, Gottingen, Germany), βIII-tubulin
(Covance, Berkeley, CA), GFAP, CaMKIIα (MAB3119) and Cre-recombinase (Chemicon,
Temecula, CA), α-adaptin, dynamin and clathrin (BD Transduction Labs, San Jose, CA), BiP
(Affinity BioReagents, Golden, CO), Rac1 (23A8, Millipore, Temecula CA), Cdk5 and PP1
(Santa Cruz, Santa Cruz CA).
Western blot analyses and Rac activation assays
For analysis of total protein, freshly dissected tissue or cells were sonicated in SDS lysis buffer
and heated for 5 min at 95°C (Ma et al., 2008). Subcellular fractionation was used to prepare
samples enriched in ER/Golgi, cytosol, synaptosomal membranes, synaptic vesicles and
synaptosomal cytosol (Huttner et al., 1983). Purified PSDs were prepared using a modification
of published procedures (Carlin et al., 1980). PSDs removed from the interface of the 1.0/1.2
M sucrose layers of an equilibrium gradient were pelleted and then solubilized by incubation
for 30 min at 4°C with 0.5% TX-100, 10 mM Hepes, pH 7.4. The identity of various Kalirin
proteins was established using differential antibody reactivity plus comigration with
recombinant ΔKal7, Kal7, Kal9, and Kal12 (produced in pEAK-Rapid cells; (Schiller et al.,
2008)). ΔKal7 expressed in insect cells using the Baculovirus expression system was purified
using Talon resin (Schiller et al., 2008). Protein concentrations were determined using
bicinchoninic acid (Pierce) with bovine serum albumin as the standard.
For measurement of activated Rac, cerebral cortex (50 mg wet weight) was homogenized in
10 volumes 10 mM HEPES, 320 mM sucrose, 10 mM MgCl2, 1 mM EDTA, 1 mM NaF, pH
7.4 containing 10 μg/ml GST-Pak-CRIB and protease inhibitor mix. Following removal of
debris (1000 × g for 5 min), Rac activation in the total lysate was assessed by adding ¼ vol 5X
MLB (Schiller et al., 2008) and allowing each sample to tumble with 15 μl glutathione
Sepharose 4B resin for 1 h at 4°C. Beads were washed twice with 1XMLB containing 8%
glycerol and bound proteins were eluted with boiling Laemmli sample buffer. Rac was
visualized using monoclonal antibody from Upstate. Crude synaptosomes were prepared by
differential centrifugation (Carlin et al., 1980); P2 was resuspended in 1XMLB containing 10
μg/ml GST-Pak-CRIB and allowed to tumble at 4°C for 20 min before centrifugation at
100,000×g for 15 min; this supernatant was bound to glutathione Sepharose 4B resin and
washed as described above. Positive and negative controls were prepared as described (Xin et
al., 2008).
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Dissociated neurons—Immunocytochemical staining of neuronal cultures was performed
as described (Ma et al., 2003;Ma et al., 2008). Neurons were generally fixed for 20 min in 4%
paraformaldehyde in PBS or with anhydrous methanol (−20°C). For visualization of synaptic
proteins including PSD-95, NR1, Vglut1, GluR1, VGAT, and Kal7, cells were fixed with
methanol for 12 min at −20°C, except where indicated. Primary antibodies were visualized
with appropriate secondary antibodies as described (Ma et al., 2008).
Tissue sections—Immunohistochemical staining of tissue sections from perfusion-fixed
mice has been described (Ma et al., 2001;Ma et al., 2002). Briefly, animals were perfused
transcardially with 4% formaldehyde/0.1 M Na phosphate buffer, pH 7.4, under deep
anesthesia with Ketamine. Following fixation, brains were postfixed in 4% paraformaldehyde
for 6 hours. Sections (10 μm) through dorsal hippocampus were cut using a cryostat and
immunostained with appropriate antibodies as described (Ma et al., 2001).
Golgi staining
Animals were perfused transcardially with 2% formaldehyde/1% glutaraldehyde (in 0.1 M Na
phosphate buffer, pH 7.4) under deep anesthesia with Ketamine (n=4, Wt; n=4, Kal7KO).
Following fixation, brains were removed and half brains were placed in 4% paraformaldehyde
overnight. Brains were then sectioned through dorsal hippocampus at 100 μm on a vibratome
and prepared for Golgi impregnation as described (Norrholm and Ouimet, 2000). The other
halves of the brains were processed for electron microscopy as described below.
Electron microscopy
Half brains prepared as described above were postfixed in 2% glutaraldehyde for 2 hours.
Brains were then sectioned at 50 μm on a vibratome and the sections were embedded in Polybed
epoxy resin (Polysciences, Warrington, PA). Ultrathin sections (50 nm) from hippocampal
CA1 stratum radiatum were cut with a Reichert Ultracut E ultramicrotome and collected on
copper grids and counterstained with uranyl acetate and lead citrate. Sections were examined
in a JEOL 100CX transmission electron microscope at 80 kV accelerating voltage. For
quantification of PSDs, images were taken at 8,000x magnification. All measurements were
performed independently by two researchers who were blind to the genotype of the animals.
Behavioral and physiological testing
Initial data—Animals were group housed in the UCHC animal facility with a 12 hour light/
dark cycle (lights on 0700 – 1900). All behavior experiments were done in accordance with
UCHC IACUC and NIH procedures for animal care. Simple physiological observations were
performed on all mice, including body weight over time and general observations such as lack
of obvious tremor, normal gait and ability to navigate/climb in the home cage. For behavioral
studies, male littermates between 2 and 4 months of age were tested during the light phase. All
animals were handled daily for at least five days before behavioral testing to minimize
experimenter-induced stress during testing. With the exception of passive avoidance testing,
all behavioral tests were carried out in dim lighting in the Scoville Neurobehavioral Suite at
UCHC. For all experiments, animals were allowed to habituate to the room for one hour before
testing. Some animals were re-used for behavioral tests, but great care was taken to ensure that
the less stressful tests preceded those that were more stressful (Elevated zero → Open Field
→ Object recognition → Radial arm → Passive avoidance). Statistical analysis was performed
using SPSS software (SPSS Inc., Chicago, IL) with one-way ANOVA or repeated measures
ANOVA to assess differences between groups.
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Open Field—Spontaneous locomotor activity was measured using a PAS Open Field system
(San Diego Instruments, San Diego, CA). Briefly, animals were placed in the center of a 15″
× 15″ plexiglas chamber and their horizontal ambulatory activity was recorded by photocell
beam breaks. Animals were allowed to move freely about the chamber for an hour for a single
testing session.
Elevated Zero Maze—The zero maze (San Diego Instruments) was made of white plastic
with two "closed" quadrants consisting of 6″ tall walls on either side and two "open" quadrants
with ¼″ walls. At the beginning of testing, each animal was placed in a closed quadrant facing
it. Behavior was monitored by a blinded experienced scorer for the next five minutes. Time
spent in the open, open entries (all four paws entering the open arm), stretch attends (stretching
of forepaws into the open arm before retraction into the closed arm) and head dips (dipping
the head over the open arm to the crux of the mandible) were scored for each animal. Entry
into a new quadrant was scored only when all four paws of the animal left the previous quadrant.
Passive Avoidance—Mice were tested using a two compartment box with footshock grid
(San Diego Instruments). On the training day, each animal was placed in the box with lights
off and the interchamber door closed. After a five second habituation, the house lights were
turned on only in the side where the mouse had been placed and the door was opened. When
the mouse crossed to the darkened side, the door was closed and a 0.3 mA × 2 sec scrambled
footshock was delivered. Mice were left in the shocked environment for 30 sec before being
returned to their homecage. For the test trial, animals were brought back to the room after the
appropriate interval and run through the same protocol, but without footshock. For both training
and testing, the latency to cross to the dark was measured using photocells in the boxes. Shock
sensitivity was assessed (Hawasli et al., 2007) with cohorts of previously shocked and naïve
animals. Animals were placed in the box and given 2 sec shocks ranging from 0.05–0.5mA. A
blinded scorer examined videotape and recorded the lowest shock that elicited vocalization,
flinching and jumping.
Radial Arm Maze—The radial arm maze was used to test both working and reference
memory. The maze (San Diego Instruments) consisted of a 5.25″ central platform with eight
arms (2″ wide × 6″ high) radiating from the platform. Extensive intramaze (distinct geometric
shapes on walls) and extramaze (objects of varying shape and size present over arms) cues
were provided throughout the testing procedures. Animals were food deprived for 5 days prior
to the start of the experiment and were maintained at 85% of their free-feeding weight
throughout training. Mice were first group habituated (3–4 mice at a time) to the maze, where
reward pellets (small pieces of Cocoa Puffs cereal, General Mills Inc, Golden Valley,
Minnesota) were scattered throughout. The mice were then given an individual habituation
session with similarly scattered rewards. During testing, the animals were placed in the maze
and confined to the center platform using a white cylinder for 15 sec. After the 15 sec
acclimation, the cylinder was removed and the animals were given free run of the maze.
Throughout the training period, two arms separated by 135° were baited with a hidden food
pellet. The baited arms were varied between animals but remained consistent for each subject.
Mice were allowed to explore the maze freely for four minutes or until both rewards were
obtained. A blinded observer watched and scored throughout each session. Reference memory
errors were scored when an animal entered an unbaited arm or when a baited arm was entered
but the reward was not obtained. Working memory errors were re-entries into arms within a
trial. Two cohorts of animals were used for this experiment. In the first (4 Wt, 6 KO), animals
were given one trial per day for the first seven days and then three trials per day for the
remaining days. Animals in the second cohort (5 Wt, 7 KO) were given two trials on the first
day and three trials on each successive day. These differences in training procedure produced
no difference in acquisition curves, so data were combined for the purpose of analysis.
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text:
Tears of happiness
During the Janmastami marathon I met a lady in a block of flats. As soon as she saw the books, she was very attracted to them. She bought the Bhagavad-gita and the first canto of Srimad-Bhagavatam. She was very thankful to me, expressing again and again her happiness that I brought these books to her. She told me that it must be by the grace of God that I came there. Then she started to shed tears profusely. Seeing I was a little bit embarrassed by this, she told me, "Do not mind these tears; they are tears of happiness."
I asked her if she knew something about the books, and she told me a story of how she had gotten some of Srila Prabhupada's books before. Once, her husband was shopping downtown when he noticed two extraordinary books lying on the bench in the town square. One was "The Science of Self-Realization," and the other was "A Second Chance." He was attracted to them but thought that somebody just forgot them on the bench and would soon come and retrieve them. So her husband went shopping, and after two hours he returned — and the books were still there! So he took them and gave them to his wife.
The lady told me that at that time she had had several life crises and that these books had helped her very much. So she was really happy to obtain more books from Srila Prabhupada. I advised her to start to chant the Hare Krishna mantra regularly and to stop eating meat. She willingly agreed and gave me her contact information.
All glories to Srila Prabhupada's transcendental books!
Your servant, Gadadhara Dasa
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subset: commoncrawl


text:
|Fishing from Kayaks and Canoes
|New Topic
|Printer Friendly Version
Posted by: Big_D on Apr-29-11 11:23 AM (EST)
But I am interested in the fishing. Hearing from a bunch of people that it's interesting paddling but they don't know about the fishing is just wasting my time.
- Big D
Recreational Kayak Paddle
Kayak Seats
EZ-Dock modular docks
|Table of Contents


text:
The Redskins are 1-5. That's pretty much it.
Check out some of the images from Sunday's Redskins game.
See Full Gallery
The Redskins will attempt to snap their three-game skid against the Cardinals.
Washington Post's Jason Reid talks about his column that criticized a few Redskins players for having the wrong attitudes after their loss to Seattle. Chris Cooley, Grant Paulsen, and Dianna Russini all discuss...
The Washington Redskins lost 27-17 to the Seattle Seahawks Monday night in Landover, Maryland. Their season record dropped to 1-4.
The defending Super Bowl champions pay a visit to Washington on Monday.
Back when the schedules were dreamed up, tonight was supposed to be a quarterback battle...
In an attempt to salvage its trademark protections, the team filed a lawsuit against the Native Americans from five different tribes.
Griffin could be back from his ankle injury by the end of October.
The head of the Federal Communications Commission said the agency will consider a petition to ban the Washington Redskins nickname from the public airwaves.
Get Redskins news sent to your inbox!


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Supersampler First Attempt :)
I spent 2 months to finish this roll. I had no idea what to shoot with it. I don't think I'm good with multi-lensed cameras.This photo was shot on film. Taken by tomkiddo with a Lomography Supersampler (available in our Online Shop) loaded with Lomography Color Negative 400 (35mm) film (available in our Online Shop) in Petaling Jaya, Malaysia. These tags describe this photo: iso400, supersampler, lomography, malaysia, mascot, duck, blue, and cute. Date: 2012-04. Time: Afternoon. This photo can also be found in the album Supersampler First Attempt!.
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Computer Class
Tech Time with NathanSubmitted by oplin on Tue, 04/01/2014 - 2:27pm
Tech Time with Information Technology Manager, Nathan. Nathan will answer your technology questions.
Tue, 05/20/2014 - 4:30pm - 6:00pm
InternetSubmitted by oplin on Tue, 03/11/2014 - 1:03pm
Search engines, medical websites, government websites, science websites, game websites, cooking websites, and websites for children. Must have basic computer skills.
Mon, 03/24/2014 - 2:00pm - 3:30pm
iPad Basics ISubmitted by oplin on Mon, 03/03/2014 - 1:26pm
Join us for the introductory class covering topics such as tailoring your settings, setting up, iCloud and searching the web on your iPad. Bring your own iPad or follow along with the library iPad.
Wed, 03/05/2014 - 2:00pm - 3:00pm
Computer Basics. April 22. 2:00 p.m.Submitted by oplin on Fri, 02/28/2014 - 3:55pm
This class will help students become familiar with their computer and is foundational for other computer classes such as Word 101 and Word 102.
Tue, 04/22/2014 - 2:00pm - 3:30pm
Readers' Advisory on the WebSubmitted by oplin on Fri, 02/28/2014 - 3:38pm
This class will review a variety of readers' advisory websites.
Mon, 04/14/2014 - 2:00pm - 3:00pm


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Dr. Stephen F. Thung, MD
Obstetrics & Gynecology, Ohio State University Maternal Fetal Medicine
- 2050 Kenny Rd FL 5& Ste 6
Columbus, OH 43221
- 2 Office Locations
- (614) 293-2222
Dr. Stephen F. Thung has been practicing medicine for 16 years. Dr. Thung graduated from the New York University School of Medicine in 1998. He practices medicine in Columbus, OH and 1 other location and specializes in Obstetrics & Gynecology. Dr. Thung is affiliated with OSU James Cancer Hospital and Wexner Medical Center At The Ohio State University. He speaks English, French, Chinese and Spanish.
Gender: Male
Years in Practice: 16 Years
Languages Spoken: English, French, Chinese, Spanish
Medical School: New York University School of Medicine
Graduation Date: 1998
Hospital Affiliations: OSU James Cancer Hospital, Wexner Medical Center At The Ohio State University
Specialties: Obstetrics & Gynecology
*This physician has multiple office locations. See Appointments for details.


text:
GLEE: THE MUSIC, THE CHRISTMAS ALBUM VOL. 3 Now Available
'Tis the season to be jolly as the GLEE Cast releases GLEE: THE MUSIC, THE CHRISTMAS ALBUM VOL. 3 available today, Tuesday, December 11. The album features timeless holiday classics, including "Have Yourself A Merry Little Christmas," "White Christmas," and "Jingle Bell Rock." Six of the tracks recorded will be included on the holiday themed episode of Glee, which airs Thursday, December 13, at 9:00 PM ET/PT on FOX. Glee: The Music, The Christmas Album Vol. 3 will also showcase 4 songs recorded exclusively for the release including "Joy To The World" and "Silent Night" (see below for track-listing).
Kick off the holiday season with this week's all new "Thanksgiving" Glee episode, as some of the recent McKinley High graduates return to Lima, OH for Thanksgiving break and volunteer to mentor the New Directioners. The festivities continue as Rachel (Lea Michele) and Kurt (Chris Colfer) celebrate a non-traditional holiday dinner in the Big Apple. This episode will feature songs recently released on Glee: The Music Season 4, Volume 1, such as One Direction's wildly popular "Live While We're Young" and Psy's dance anthem "Gangnam Style." Glee airs Thursdays at 9:00PM ET/PT on FOX.
From the iconic "Don't Stop Believin'" to the pop phenomenon "Teenage Dream" to the widely praised mash-up of Adele's "Rumour Has It" and "Someone Like You," Glee has sold more than 49 million songs and over 12 million albums worldwide. Glee scored three consecutive #1 releases with Glee: The Music, The Power of Madonna, Glee: The Music, Volume 3 Showstoppers, and Glee: The Music, Journey To Regionals. The RIAA has certified Glee: The Music, Volume 1 and Glee: The Music, The Christmas Album Platinum (sales in excess of 1 million units) as well as Glee: The Music, Volume 2, Glee: The Music, Volume 3 and Glee: The Music, Volume 4 Gold (sales in excess of 500,000 units).
The full track listing for Glee: The Music, The Christmas Album Vol. 3 is as follows:
Jingle Bell Rock
White Christmas
Have Yourself A Merry Little Christmas
Silent Night*
Joy To The World*
The First Noel
I'll Be Home For Christmas*
Feliz Navidad
Hanukkah Oh Hanukkah
Happy Xmas*
*=bonus track (not in an episode)
|Related Links
|Bob Schneider and Hayes Carll Play the Fox Theatre Tonight
May 29, 2014
About Author
- The 2014 AMERICAN MUSIC AWARDS- All the Winners!
- VIDEO: SNL & Cameron Diaz Parody New ANNIE Film with 'Sneak Peek'
- Ariana Grande Performs, Pitbull Hosts the 2014 AMERICAN MUSIC AWARDS Tonight on ABC
- Disney Channel Airs SOFIA THE FIRST Primetime Special Tonight
- PIRATES OF THE CARRIBEAN Trilogy Airs on WGN Today
- NBC Sports Airs Coverage of First Leg of EASTERN CONFERENCE CHAMPIONSHIP Today
- CBS SUNDAY MORNING Airs 'Eat, Drink & Be Merry' Edition Today
- Chef Ina Garten Visits Today's CBS SUNDAY MORNING
- Tina Fey's UNBREAKABLE KIMMY SCHMIDT Moving from NBC to Netflix
- VIDEO: James Corden Talks New Late Night Hosting Gig & More on LETTERMAN


text:
comes from the root prashant a gross indian kid - a disease that comes off of this kid that is never cured and the only way to cure it is to be killed.
Steve died of grossshantiosis last spring.
by steve March 02, 2005
10 Words Trending Now
Alphabetical List
Type your email address below to get our free Urban Word of the Day every morning!
Emails are sent from firstname.lastname@example.com. We'll never spam you.×


text:
Arbor Realty Trust (ABR) Ex-Dividend Date Scheduled for February 21, 2014
Arbor Realty Trust ( ABR ) will begin trading ex-dividend on February 21, 2014. A cash dividend payment of $0.13 per share is scheduled to be paid on February 28, 2014. Shareholders who purchased ABR stock prior to the ex-dividend date are eligible for the cash dividend payment. This marks the 3rd quarter that ABR has paid the same dividend.
The previous trading day's last sale of ABR was $7.09, representing a -17.56% decrease from the 52 week high of $8.60 and a 22.66% increase over the 52 week low of $5.78.
ABR is a part of the Consumer Services sector, which includes companies such as Simon Property Group, Inc. ( SPG ) and American Tower Corporation (REIT) ( AMT ). ABR's current earnings per share, an indicator of a company's profitability, is $.41. Zacks Investment Research reports ABR's forecasted earnings growth in 2014 as 32.5%, compared to an industry average of -12.6%.
For more information on the declaration, record and payment dates, visit the ABR Dividend History page. Our Dividend Calendar has the full list of stocks that have an ex-dividend today.


text:
Black Friday is Here!
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Black Friday is Here!
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Dinty Moore Beef Stew, Microwave Bowl Easy to make chunks of beef and vegetables covered in gravy Dinty Moore Beef Stew, ...
This Web site is intended for use by US residents only. See International Sites. See our delivery policy for full details. Copyright 1998-2014, Staples, Inc., All Rights Reserved.


text:
I want to sniff network packets without wincap library, kindly give me some hints or direction so that I can make it possible.
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.
You know, libpcap exists for a reason: It does something that's necessary.
You need to set up a system-level hook for TCP/IP events, and the way global hooks work means you need to do this from a DLL.
Having hooked those events, you have to figure out the contents of the packets you get.
Are you sure you want to re-invent this wheel?
I found some introductory info on hooking Windows events here.
You could start to do kernel level programming and catch there the packets. This is for sure complicated but you'll learn much.


text:
All in the Family
The Detroit News looks at the Michigan House field in the Aug. 5 primaries and considers that term limits, which is forcing out 44 state reps, has ...
The Detroit News looks at the Michigan House field in the Aug. 5 primaries and considers that term limits, which is forcing out 44 state reps, has led to an odd kind of nepotism. Multiple family members are looking to take over vacated legislative seats.
o Todd LaJoy, son of Rep. Philip LaJoy, R-Canton, is running to succeed his dad. Ditto Bryan Brandenburg, who wants to move into the seat of Rep. Jack Brandenburg, R-Harrison Township.
o Linda Steil is running for the seat of husband Rep. Glenn Steil, Jr., R-Grand Rapids. Eileen Kowall of White Lake is running for a seat once held by her husband Mike.
o Jim Stamas, a Midland Republican vying for a House seat, could join his brother, Sen. Tony Stamas, R-Midland. Mike McManus, running for a House seat, could share rides to Lansing with his daughter, Sen. Michelle McManus, R-Lake Leelanau.
Join the Discussion
After you comment, click Post. You can enter an anonymous Display Name or connect to a social profile.
Are Muni Bonds Being Replaced by Direct Loans?1 day ago
Unrest Continues in Ferguson1 day ago
To Save Money, Cal State Considers Not Accepting Freshmen at All1 day ago
Judges Overturn Gay Marriage Bans in Mississippi and Arkansas1 day ago
How the GOP's Rust Belt Governors Might Fix its 1% Problem1 day ago
New San Francisco Rule Prevents Employers from Changing Worker Schedules1 day ago


text:
Follow Us:
ROCKY HILL, Conn., and ST. LOUIS – A combined ATG Rehab and United Seating and Mobility will have a whopping 124 locations in 39 states, but there may be room for further growth, say company execs.
WASHINGTON – A pair of U.S. senators have some hard questions for CMS regarding overpayments to The Scooter Store.
Among them: Does CMS plan to recoup more of what it's owed by the power wheelchair provider?
ROCKY HILL, Conn. and ST. LOUIS – Two of the three major players in the complex rehab market have joined forces.
ROCKY HILL, Conn. and ST. LOUIS – Two of the three major players in the complex rehab market have teamed up.
NASHVILLE, Tenn. – Wellspring Capital Management acquired National Seating and Mobility (NSM) from Ridgemont Equity Partners, the complex rehab provider announced Jan. 2.
WALSENBURG, Colo. – NRRTS wants to make sure its registrants are on the radars of case managers, says Simon Margolis.
ATLANTA – A recent surge of audits in Jurisdiction C are targeting "low-lying fruit," older claims that are more likely to have problems, say consultants.
WALSENBURG, Colo. – Weesie Walker is only the second person in NRRTS's 20-year history to be named a NRRTS Fellow. She retired from her position as a branch manager for National Seating and Mobility in Atlanta in December.
INDIANAPOLIS – Home Health Depot's latest buy is a "perfect marriage" for both companies, says Nathan Feltman.
Editor's note: This is the last in a three-part series.
YARMOUTH, Maine – National companies might be on the buying path these days, but some independent providers say they're here to stay—even if it's not easy.
Open Standard Media Player version 1.3
Repair relief needs to be two-fold
Thursday, December 11th, 12 pm ET
© 2014 United Publications Inc. ALL RIGHTS RESERVED


text:
Brad Biggs joined the National Football Post in August 2009. He is entering his ninth season covering the Chicago Bears and currently is on the beat for the Chicago Tribune. He has written for numerous other publications, including the Sporting News. He graduated from the University of Missouri with a B.A. in political science and is the NFC North division representative for the Pro Football Writers of America.
Rams can break lease after 2014 season
Cardinals safety out to prove doubters wrong
Contract says he must do so in Michigan
New coordinator leading transition on defense
Prosecutors weighing possible charge for 49ers linebacker
Veteran safety could join mix in Carolina
Ex-cornerback also set to be analyst for Fox Sports
49ers LB accused to attacking teammate
Be interesting to see how high New York goes for receiver
19 were killed in deadly Arizona blaze
Coach dispels notion Freeman in competition
Seahawks WR finally emerged in 2012
NOV 20 Joel Corry
Will there be first ballot Hall of Famers in 2015?
A detailed look at the eight candidates vying for that unique honor.
NOV 18 Dion Caputi
Cleveland quarterback Brian Hoyer has overcome long odds to put his team in contention for a playoff berth.
NOV 13 Joel Corry
The NFL's most underpaid players
10 players who are delivering big returns for their respective franchises.


text:
Home > All Cities > UNIVERSITY PARK, FL Real Estate Listings > RIVA TRACE Subdivision
Properties for sale in the RIVA TRACE Subdivision, UNIVERSITY PARK, FL
Properties 1 to 2 of 2
7530 E RIO BELLA, BRADENTON, FLList Price: $585,083 | Bed:3 | Bath:2.00
Medallion Home's St. Thomas model boasts an open floorplan that is perfect for entertaining. This luxurious model home has been carefully designed and decorated by a professional interior designer to provide you with some of the finest upgrades available. Simply bring your clothes and move right in. This one of a kind home is available for lease back. No detail has been overlooked in this home. Wood floors, gourmet kitchen with Jenn-Air appliances, pool and spa, outdoor kitchen, custom closets and crown molding. Riva Trace is a quaint, gated community hugged by the peaceful Braden River and lush, forested grounds located just minutes from The Mall at University Town Center. No CDD fees in Riva Trace. This home comes with a 1,2,10 year warranty with Medallion Home. LOT 4 RIVA TRACE PI#19189.1120/9
Listing Office: Medallion Real Estate | MLS ID#: M5900679
8049 RIO BELLA, UNIVERSITY PARK, FLList Price: $517,500 | Bed:2 | Bath:2.00
This spacious Great Room plan features $150,000 + in upgrades, 2/2 + den, master spa, beautiful chef's kitchen with stainless appliances, granite countertops, 42 upgraded cabinets and trim, upgraded tile flooring throughout home with upgraded carpet in bedrooms, 13' ceiling and rope lights in foyer with 15' tray ceiling, 11' ceilings throughout with 13' tray ceiling with rope lights in great room, crown molding throughout house, upgraded trim package, 12 pocket sliding glass door in great room, large lanai with gorgeous view overlooking pond attached to Braden river, complete privacy with extensive landscaping, and all windows and doors protected by Sentry Protection Crime safe technology which is a stainless steel security mesh and frame system designed for security protection, hurricane protection, energy reduction, and insect control. Riva Trace is a gated, maintenance free, boutique community with only 86 home sites, nestled on the Braden River without CDD fees. LOT 67 RIVA TRACE PI#19189.1435/9
Listing Office: Community Realty Associates | MLS ID#: T2706233


text:
Editing of Bulbapedia is currently restricted. Please see this message for more details.
Pokémon Omega Ruby and Alpha Sapphire have arrived!
Check BNN and Bulbanews for up-to-date Pokémon news and discuss it on the forums or in our IRC channel.
Talk:World Championships Tournament
From Bulbapedia, the community-driven Pokémon encyclopedia.
(Redirected from Talk:World Championships Tournament/Junior Division)
How is there initial and fixed? Was there a problem in the original distribution? --Abcboy (talk) 21:14, 24 October 2012 (UTC)


text:
Online dating brings singles together who may never otherwise meet. It's a big world and the SeniorPeopleMeet.com community wants to help you connect with singles in your area. Whether you are seeking just a date, a pen pal, a casual or a serious relationship, you can meet singles in Connecticut today! Connecticut is known for its rich history and SeniorPeopleMeet.com is here to bring their Senior Singles together.Search Single Senior Men in Connecticut | Search Single Senior Women in Connecticut
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text:
Abbreviation for "pissed off"
I tried to get through to her, but she was too P. O.'d to listen.
додав Alexander Hu 24 Січень 2008
"ooooh you bastard right in the pods"
додав simon woodward 18 Вересень 2003
a term used in poker games and is derived from the two words, pot odds, implying the odds of the pot.
pot odds pods
pot odds pods
i dont want to fold there are some really good pods.
додав hurleyburley23 19 Квітень 2008
The Punani Odor Department. A Department in which things can either be complained about or appreciated. Mentioned only in awful cases of smell.
"Damn, Brittany, I have a complaint to file in the P.O.D"
додав Complaintobrittany 8 Вересень 2009


text:
Waterbury VT 69 Harvey Farm
Price: $479,000
Est. Mortgage: $/month
MLS Number 4394446
- Residential
- Bedrooms 4
- Bathroom 4
- Square Feet 4118
- Acreage 0.93
Located adjacent to common land with mountain views. Great sunlight fills this 3 bedroom home with attached two car garage. Neighborhood features 150 acres of common land with trails for year round recreation. Just minutes from exit 10 this convenient location works well for primary or second home use.
Listed by Gayle Oberg of Coldwell Banker Carlson Real E
Save FavoriteSchedule A VisitAsk A QuestionMore Details
|Down Payment
|Interest Rate
Est. Mortgage: $/month
Federal 30-year interest rate: 3.99% last updated on 2014-11-20
This product uses the FRED® API but is not endorsed or certified by the Federal Reserve Bank of St. Louis.


text:
Find records of Beaulah Haynes
Find birth, death, marriage, military, and other records of Beaulah Haynes at Ancestry.com.Search for records
Biography & Family History Add details
Beaulah Haynes (1920 - 2008) was born on October 1, 1920. She was born into the Haynes family.
There are no known spouses or children on record for Beaulah. Beaulah died on April 18, 2008 at 87 years old.
Beaulah Haynes's last known residence is at Nacogdoches, Nacogdoches County, Texas.
We find a death record for Beaulah Haynes in the United States Social Security Master Death Index (SSDI). According to information provided to the SSDI, this death record has been verified by a family member of the deceased. This data can be considered very accurate. What is the SSDI?
This genealogy of Beaulah Haynes's past is maintained by AncientFaces members Add facts about Beaulah to connect to the people who knew her. Some common things we would like to know about Beaulah's genealogy:
- Where was Beaulah born?
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History of Beaulah Haynes Add details
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- Last Known Residence
- Nacogdoches, Nacogdoches County, Texas
- Born
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- Female
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Possible Relatives
- Burke Haynes
- ·
- Cleaven Haynes
- ·
- Bessie Haynes
- ·
- Nonice Haynes
- ·
- Weass Haynes
- ·
- Lola Haynes
- ·
- Vivian Haynes
- ·
- Cleo Haynes
- ·
- Alice R Haynes
- ·
- Ora Haynes
- ·
- Mauricio Haynes
- ·
- Lonzetta Haynes
- ·
- Ruth Haynes
- ·
- Dianne R Haynes
- ·
- Ed Haynes
- ·
- Howard G Haynes
- ·
- Winnie Haynes
- ·
- Lorraine v Haynes
- ·
- Maxine M Haynes
- ·
- Homer O Haynes
- ·


text:
Ellie Bellie Kids just launched a new line of rainbow robots.
You should swing over and check them out.
Just so happens they're funny too.
Latest posts by Stacy (see all)
- Why I travel with a NOOK by Samsung (& how you can WIN one!) - November 8, 2014
- The Easiest (WyldStyle) Wildstyle Lego Movie Costume Ever! - September 26, 2014
- Fantastic Mr. Fox come to life through the eyes of Tobias Picker and Emily Carew Woodard - September 24, 2014


text:
The Economist explains: How Black Friday hit Britain
The Economist explains
Radiation and evolution: Surviving fallout
Birds can evolve to cope with the lingering effects of nuclear incidents11
Nuclear power: The 30-year itch
America's nuclear industry struggles to get off the floor77
Japan's electricity industry: Power politics
A troubled utility is to be as good as nationalised11
Japan's nuclear crisis: The meltdown and the media
Where a slight change in protocol marks a world of difference5
Banyan: The Fukushima black box
A dangerous lack of urgency in drawing lessons from Japan's nuclear disaster39
French nuclear energy: Under pressure
France wants to export nuclear reactors. Who will buy them?38
The Economist: Digital highlights, December 3rd 2011
Items from the digital highlights page0
Cleaning up Japan's nuclear mess: The twilight zone
Its owner fears not just radiation leaking out of the Fukushima plant, but also bad news171
Japan's nuclear conundrum: The $64 billion question
Once the Fukushima nuclear plant is stable, the government should temporarily nationalise its operator108
Disaster prevention: Difference Engine: Whole lot of shaking
Small earthquake in Virginia rattles more than nerves29
Radiation in Japan: Hot concern
Japan risks another crisis over decontamination7
Tokyo's luxury retailers: Cold-hearted door policy
Darlings of the high street seem to be flaunting their lack of public virtue33
Japan's recovery: Who needs leaders?
The aftermath of the March 11th disasters shows that Japan's strengths lie outside Tokyo, in its regions16
BP's energy review: Bouncing back
New figures show extraordinary growth in energy use last year4
Japan's nuclear disaster: Piecing together Fukushima
Nuclear experts hear new details of the Fukushima disaster26
France's nuclear-energy champion hopes to benefit from a flight to safety3
Japan's unhelpful politics: Rebuilding Japan—or ruining it
A precarious future for the country, but its politicians are self-absorbed17
The world has admired Japan's stoic spirit. But there is a worrying side to it37
Lessons from Deepwater Horizon and Fukushima: In place of safety nets
Don't assume disasters won't happen at the frontiers of technology—presume they will20
The Economist: Digital highlights, April 16th 2011
Items from the digital highlights page of The Economist, April 16th 20110
Japan's nuclear crisis: It's the worst; it's also not so bad
There is no end to the crisis at the Fukushima nuclear-power plant. But it could be worse17
The Economist: Digital highlights, April 9th 2011
Items from the digital highlights page in The Economist issue of April 9th 20110
E-commerce and data security: The phishers' big catch
A large theft of company e-mail lists causes controversy1
Coping with Japan's nuclear disaster: Living with radiation
A spreading cloud of economic and human costs57
The Economist explains: How Black Friday hit Britain
The Economist explains
Jobs for young Southerners: Thanks for nothing
Democracy in America
Ebola in graphics: The toll of a tragedy
Graphic detail
Interactive Ebola map: The journey of a virus
Graphic detail
Internet on aeroplanes: A $1,171 Wi-Fi bill
Safety in cricket: The bravery of the batsman
Game theory
House prices at the border: Staying Dutch
Free exchange
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text:
Do you have a press release for your upcoming gigs or live music events? Tell us all here...
Cambridge band Stoker will be special guests to Four Wheel Drive on Saturday 26th November at Melbourn Rock Club. www.melbourn-rock-club.com (Read More ....)
By Melbourn Rock Club() on Friday 25th November 2011, 11:11:39 (0 comments)
The Lock Up Rehearsals
If you're looking for a cheap place to rehearse in Cambridge check out 'The Lock Up' (we even have a ladies toilet key now!!) www.thelockup.org (Read More ....)
By The Lock Up() on Monday 21st November 2011, 09:11:02 (0 comments)
Last Gang In Town present Punky Ska Reggae party with NEW TOWN KINGS + THE MINX Sat 17th Dec
LAST GANG IN TOWN present...XMAS PUNKY - REGGAE - SKA PARTY with...NEW TOWN KINGS - New Town Kings are a 9 piece Ska/Reggae band from Colchester. Since 2006 they have been rocking venues and festivals across the UK and Europe with their own brand of Ska, Rock-steady and Reggae. (Read More ....)
By Last Gang In Town() on Sunday 20th November 2011, 20:11:25 (0 comments)
Saturday November 19th 2011 7.30pmA Live Tribute To cliff Richard And The shadowsYaxley RBL. Yaxley. Peterborough cambs PE7 3NRfull details atwww.thetwylightshadows.webs.com (Read More ....)
By PERRY DENNIS & THE TWYLIGHT SHADOWS() on Friday 18th November 2011, 12:11:06 (0 comments)
New open mic night starting in Cambridge
Hi everyone,I'm wanting to start a new open mic night in Cambridge and am wanting to hear from anyone who might be interested in performing at it.Anyone 18 and over is welcome to perform. (Read More ....)
By Mr Benjamin() on Wednesday 9th November 2011, 16:11:14 (6 comments)


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The Swiss are said to be packing it in on the West Coast. Read more »
Layoffs Watch '13: UBS WestBy Bess Levin
Bonus/Layoffs Watch '13: UBSBy Bess Levin
Both are expected to go down shortly. Read more »
Bonus Watch '13: UBSBy Bess Levin
…employees will get their bonus numbers when management feels like giving them their bonus numbers! Read more »
Carsten Kengeter, who finds inspiration in interesting places, has left the building (and been replaced by a Bear Stearns alum). Read more »
You can question some of the life choices that Tom Hayes, a/k/a Trader A, UBS's Libor-manipulating-est Libor manipulator, has made, but this seems to me inarguable:
Citigroup executives wooed him in June 2009 at a swanky bar in Tokyo. As they showered him with praise, say people who were there, Mr. Hayes rarely spoke, instead letting his girlfriend, a lawyer, answer questions.
Shady traders: date lawyers! And let them do all the talking for you.
That detail is from this amazing Wall Street Journal article about Hayes. When we last discussed Hayes and his totally open and casual requests to people he'd just met to manipulate Libor for him, I asked "is this: (1) all of these people did not fully realize that they weren't supposed to be doing what they were doing, (2) UBS's culture was one of complete lawlessness and fuck-around-ery, or (3) both of those things are true and reinforce each other?," and per the Journal the answer is fascinatingly (3).
I've occasionally said that Hayes made a career of Libor manipulating but that's not entirely right. He started at RBS and, per the Journal's account,1 spent his time there mainly being smart and dressing "like a college student — with washed out jeans, a polo shirt and sometimes a threadbare sweater" rather than IMing people to ask them to fix Libor. (That, at RBS, seems to have come later.) Then he moved to UBS: Read more »
Posted in:
Credit Suisse And UBS Put Little Pieces Of Themselves In Their Compensation PlansBy Matt Levine
Swiss bank annual earnings are here so we might as well check in on what they're up to with comp. You and I may think of comp in pretty straightforward ways – if you did good, and your employer did good, you get paid well, and if not not – but Credit Suisse and UBS take a delightfully arcane wheels-within-wheels approach, constantly changing how they pay employees to send signals, fine-tune incentives, and optimize regulatory capital. I suppose if I worked there I'd be so pleased by the complexity of the edifice that I'd be okay with otherwise disappointing pay. Current employees may disagree.
Anyway we talked about UBS the other day; per the FT they are handing out bonuses in the form of high-trigger CoCo bonds that get written down to zero if UBS's regulatory capital falls below 7 percent. The bonds "will pay a market-based interest rate" though that's not saying much; any interest rate is "market-based" in the sense that it can be decomposed into, like, Treasuries plus a number. Presumably the number here is high.
Credit Suisse's entry is out today and it is a bit of a retreat from previous years' glories; here's how CS describes it in its financial report: Read more »
RBS's Seating Arrangements Deprived The World Of Untold Embarrassing IM ConversationsBy Matt Levine
It's getting to be a struggle to be amused by Libor manipulation chats. RBS took its lumps today, and the CFTC and FSA orders are full of quotes, and you can read them in various round-ups, but, meh. Even Bart Chilton is bored; today's imagery ("sends a signal to those who would monkey around with benchmark rates … much more than a slap on the wrist …") is a letdown after his UBS masterpiece ("Financial sector violations are hurtling toward us like a spaceship moving through the stars") just a few weeks ago. I get it! Everyone manipulated Libor! In writing! And then they were like "heh, fukin awexome man, u manipluated libor, gud work, i sexx u now, w champain." Fabulous.1
Part of why RBS provides less delight than its predecessor Libor-settlers is that RBS made use of the oldest and most reliable way to avoid typos: not typing. From the CFTC order: Read more »


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[July 25, 2013]
Court ready for big week
Jul 24, 2013 (The Observer - McClatchy-Tribune Information Services via COMTEX) -- Last week, Bailey Dutcher, Shai Allen and Sarah Kunkle were just three more sets of hands at the rodeo grounds in Joseph -- joining teams of volunteers to ready the site for the biggest event of the year.
Today, they are royalty, resplendent in one of their many well-chosen outfits and ready for the grand entry at the 68th Chief Joseph Days Rodeo.
From dust to regalia, the court, like three Cinderellas, put away the weeding/painting/garbage collecting clothes for their cowboy hats and spurs this week; three ambassadors of one of the best small rodeos in the country.
The girls' first outing this year, the Lilac Parade in Spokane, Wash., was a new destination for the Chief Joseph Days court and they were rewarded with first prize in their category.
"It was so big and we were on TV," Dutcher said.
They came home to Eastern Oregon for the Livestock Show and the court coronation where Wallowa County's own Sydney Cooney serves on the EOLS court.
Allen was a member of last year's Livestock Show court and knows the drill very well. Dutcher's cousin, Cheyenne Knight, is on the Elgin court, so the whole northeastern corner of Oregon is like a big family.
Dutcher said she is surprised at the attention the court gets. "People wave and walk up and talk to you and are interested in you." Chaperone Brinda Stanley agreed that the court gets quite a bit of attention, especially in their official parade day outfits.
"When I see these girls put up posters in La Grande people ask them where they are from -- they get so admired in their suedes," Stanley said.
The girls get a lot of attention with their cowgirl curls, their outfits and their horses -- this court can ride and ride well. The girls have done their run-ins during the grand entry at other rodeos, but this week they do it at home and join the Tuckerettes riding group that ushers in each night of the rodeo.
"Not just every kind of horse can handle that pressure," Kunkle said.
Allen, a consummate horse woman, joins the girls for practice at the arena after her job at the Eagle Cap Pack Station at Wallowa Lake. Her trusty steed, Oscar, who loves the run-ins, has a hurt shoulder. Appropriately enough her borrowed horse for the rodeo is named "Mayday." Kunkle, too, has grown up on horseback and her mount, Tipper, is an old hand at rodeo courts; he was Kunkle's sister Tricia's horse when she was queen.
The grounds are tidy, the buildings are painted and the court is ready to greet the crowd of thousands that is descending on Joseph this week.
___ (c)2013 The Observer (La Grande, Ore.) Visit The Observer (La Grande, Ore.) at www.lagrandeobserver.com Distributed by MCT Information Services
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11 Reasons Selena Gomez Is Going To Be An Awesome Big Sister
Selena's mom, Mandy, just had a baby girl! Is it weird to be jealous of a baby?
1. She's great with kids.
2. Free Selena Gomez concerts forever.
5. She knows what to say in a moment of struggle.
6. She knows that junk food can fix any problem.
8. She played the best Disney Channel character ever, Alex Russo.
9. She'll always be up for a dance party.
Check out more articles on BuzzFeed.com!


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Turkish appliance maker Arcelik said its 2012 revenue was up 25.1%, reaching 10.557 billion Turkish lira (approx. USD $5.923 billion), from 8.437 billion lira in 2011. Arcelik's net income was 552 million lira (approx $309.7 million), up 2.0% from 541 million lira in 2011. The company reported a gross profit of 28.9%.
Arcelik's 2012 White Goods appliances business revenue was 7.079 billion lira, up 27.3% from 5,560 billion lira in 2011. White Goods gross profit was 32.0%, from 32.9% in 2011.
Arcelik's 2012 Electronics business revenue was 1.798 billion lira, which was up 23.9% from 1.451 billion lira in 2011. Electronics' gross profit was 19.3%, from 22.1% in 2011.
Arcelik's "Other" business segment revenue was 1.679 billion lira, up 17.8% from 1.426 billion lira in 2011. Gross profit for the Other business was 26.3%, from 27.3% in 2011.
Arcelik expects stable or increasing market share in its key regions in 2013. In Turkey, the company expects its White Goods appliances volume growth to be 4-5%, which is in-line with GDP growth expectations. Internationally, White Goods appliances volume growth it expected to be about 10%.
Total revenue growth in 2013 is expected to be greater than 10% in lira.
The company expects to see a positive impact in 2013 from the launch of white goods appliances under its Grundig brand name. Grundig has traditionally been a consumer electronics brand.
Arcelik is part of the consumer durables business of Turkish conglomerate Koc Group, and is a market leader in Turkey in many residential appliance and consumer electronics segments. Its Beko brand of appliances has a strong share of the appliance market in the UK and other European markets.
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June 2014: Appliance Magazine Market Insight: April 2014


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Drinkable Gold May Have Killed King's Mistress
Listen to the Story
A British medical journal has published findings saying a mistress of 16th-century French King Henry II may have died from consuming too much drinkable gold. Experts examining the exhumed remains of Diane de Poitiers, found deadly levels of gold in her hair. The popular drink was believed to preserve youth.
Copyright © 2009 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.
RENEE MONTAGNE, host:
Good morning. I'm Renee Montagne. In 16th century France, drinkable gold was the pomegranate juice of the day, believed to keep you young forever. But it may have killed a mistress to two kings. Experts examining the exhumed remains of Diane de Poitiers found deadly levels of gold in her hair. While drinking gold didn't live up to its promise, Diane had reasons to believe it was an elixir of youth. She was mistress to Henry II, who was 20 years her junior.
It's MORNING EDITION.
Copyright © 2009 NPR. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to NPR. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.
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Payday loans no paper work: Effective monetary fund with effortless procedure
If you are looking for easy loan source where you get loan without doing much paperwork and you want save your time and effort then payday loans no paper work help you in that case. These loans help you with strong fiscal support without facing any difficulty. Apply now! please visit at http://www.loansnopaperwork.co.uk/payday_loans_no_paper_work.htm


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Fugitive lip biter arrested in California
Nov 6, 2014
Jonathan E. Benedict
Oct 30, 2014
Darrell W. Cook
Oct 2, 2014
Michael Polchies
Sep 25, 2014
Home » News » Crime
Portsmouth pharmacy robbery ends in crash and arrest; motorist injured
Cheryl Lees, 59, of Portsmouth, was arrested after police spotted her SUV and gave chase.
Officers had received a report that a woman passed a note demanding pain medication at the Rite Aid Pharmacy on Islington Road. Police said the robber left in a white SUV, which was spotted on nearby on Middle Street.
As an officer attempted to catch up to the vehicle, it accelerated, crashing into another vehicle on Lafayette Road. Police said the woman then fled on foot but was captured after a brief struggle outside her apartment building on Ledgewood Drive.
Lees was charged with robbery, conduct after an accident, disobeying a police officer, resisting arrest and possession of a controlled drug. She was ordered held on $8,000 cash bail and will be arraigned Tuesday.
One occupant of the other car involved in the crash suffered minor injury, police said.
- Innocent verdict in vehicle death of former Amherst Fire Chief - 0
- NH Guard Officer convicted of sex trafficking - 0
- MBTA sergeant facing a dozen charges after multiple arrests - 0
- Portsmouth mechanic arrested Friday on theft charges - 0
- Police looking for person who apparently abandoned dog Friday at Concord Dog Park - 0
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Police searching for person stealing from cars in ManchesterREADER COMMENTS: 0
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Jury acquits Mont Vernon driver, who was checking text, in death of former Amherst fire chief
Obama to illegals: Come out of shadows
Offend someone? To jail with you!
Driver acquitted in Amherst ex-chief's death
Jury acquits Mont Vernon driver, who was checking text, in death of former Amherst fire chief
Plaistow town planner arrested
- Whom do you think bears the brunt of the blame for the mayhem this weekend in Keene?
- KSC students
- 37%
- KSC administration
- 2%
- Police
- 6%
- Visitors from out of town
- 18%
- A combination of any/all of the above
- 37%
- Total Votes: 2483


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Quick Search
HometownRant Rental and Renters Blog for Providence, RI
Park It
Hey there all you renters, landlords, property owners and managers. As it gets generally colder and wetter across the nation, unless you're one of the tenacious few who refuses to stop biking no matter what, you're probably going to be driving more. Even if you live somewhere where the climate mostly stays the same, you still probably drive a lot. So listen up to the Hometown Rant's guide to parkin' your whip.Read More....
Pricing and Products
Advertise Your Listings
ProvidenceRent.com offers simple and effective annual advertising subscriptions to help you fill your vacancies. Subscriptions last for one year, and are based on the number of properties you manage. Subscriptions can be upgraded or extended at any time. Learn more »
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Featuring a listing allows you to jump your property to the head of our search results, guaranteeing home page placement. Learn more »
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Make your listings and your company stand out with our branding packages, which add your logo and a link to your website on every one of your listings for one year. You'll raise your own website's search engine rankings and get more traffic to your site. Learn more »
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Just for signing up today, we are happy to give you the following free advertising package:
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All we ask in return is that you give us feedback about our website, spread the word to other Providence area property managers and landlords, and deactivate your listings when they are rented.
Before you can purchase our services, you need an account on ProvidenceRent.com.


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Book your room at Peppers Parehua, Martinborough
Garden CottageMax Occupancy: 2 guests (up to 1 child, 1 infant)
Secluded CottageMax Occupancy: 2 guests (up to 1 child, 1 infant)
Winemakers CottageMax Occupancy: 2 guests (up to 1 child, 1 infant)
Lakeside CottageMax Occupancy: 2 guests (up to 1 child, 1 infant)
Woodland VillaMax Occupancy: 4 guests (up to 3 children, 2 infants)
5-star luxury apartment in Martinborough with an attached winery
Situated on a lake, this luxury apartment is close to Palliser Estate, Muirlea Rise, and Martinborough Vineyard. Nearby attractions also include Ata Rangi Vineyard.
Property Features
In addition to a restaurant, Peppers Parehua, Martinborough features a seasonal outdoor pool. Other amenities include an attached winery and a bar/lounge.
Room Amenities
In addition to satellite television, guestrooms include deep soaking bathtubs, kitchens, and fireplaces.Information missing or incorrect? Tell us!
Peppers Parehua, Martinborough
Hotel Amenities
A winery is attached to this Martinborough apartment. The apartment offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary high-speed wireless Internet access.
3 meeting rooms are available. This luxury apartment also offers a seasonal outdoor pool, tour/ticket assistance, and a garden. Complimentary self parking is available on site.
- Luggage storage
- Free Wi-Fi
- Breakfast available (surcharge)
- Safe-deposit box at front desk
- Bar/lounge
- Total number of rooms - 28
- Conference space
- Fireplace in lobby
- Tours/ticket assistance
- Garden
- Restaurant
- Winery attached
- Number of meeting rooms - 3
- Tennis on site
- Free self parking
- Outdoor seasonal pool
- Wedding services
Family Friendly Amenities
- Free Wi-Fi
- Kitchen
- Washer/dryer
- Refrigerator
- Microwave
- DVD player
Room Amenities
- Daily housekeeping
- DVD player
- Fireplace
- Premium bedding
- Air conditioning
- Microwave
- Kitchen
- Refrigerator
- Minibar
- Coffee/tea maker
- Private bathroom
- Bathrobes
- Complimentary toiletries
- Hair dryer
- Deep soaking bathtub
- Iron/ironing board
- Television
- Washer/dryer
- Satellite TV service
- Yard
Where to Eat
Full breakfasts are available for a surcharge and are served each morning between 8:30 AM and 10:30 AM.
The Pavilion - This restaurant serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Hiking/biking trails nearby
- Ecotours nearby
- Bicycle rentals on site
- Tennis on site
Hotel Policies
Check-in time starts at 2 PM
Check-out time is 10 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No pets or service animals allowed
We should mention
No pets and no service animals are allowed at this property.


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Monkey & Crocodile
High Paths Estate
Until Sun Jul 7 2013
- Free
Jane Hobson
Time Out says
Posted: Tue Jun 4 2013
Coming to a playground near you, Metta Theatre's new show features aerial circus, acrobatics, live music and skateboards. Monkey and Crocodile are new best friends, but Crocodile's mother has other plans, so Monkey must keep her wits about her. Following from the company's 'Arab Nights' at Soho theatre, this arrives in Wimbledon in association with Polka Theatre after premiering at the Greenwich and Docklands International Festival.
ReviewsAdd +


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Kingston, Jamaica, CMC – West Indies off-spinner Shane Shillingford made an immediate impact on his return to first class cricket, rattling Jamaica on the opening day of their fourth round, Regional Four-Day match against the Windward Islands here Friday.
Bridgetown, Barbados, CMC – Half-centuries from left-hander Omar Phillips and wicketkeeper Shane Dowrich, led a steady Barbados batting effort on the opening day of their fourth round clash with Trinidad and Tobago.
Jamaica Star article.
Kingston, Jamaica - Emerging opener John Campbell is happy with the way he has started his regional first-class career.
St John's, Antigua - The fourth round of the Regional 4-Day tournament gets going today with three matches across the Caribbean community.
JCA Press Release.
Kingston, Jamaica- Jamaica's regional four day captain Tamar Lambert is anticipating a humdinger of a match when his championship leading side take on the third placed Windwards in fourth round action at Sabina Park starting on Friday.
West Indies Cricket Board Inc.
P.O. Box 616 W, St. John's, Antigua
Tel : 268-481-2450
Fax : 268-481-2498
Email: email@example.com


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More Videos...
Supercharged Trans-Am Firehawk Vs. 2005 Yamaha R6
'99 Firehawk VS. '05 R6 Raven! T/A was at 503 RWHP at the time. Since
this video, T/A NOW makes 551 RWHP 504 RWTQ @ 7.5PSI.
Round 2 to come!
Twin Supercharged Lightning part 1.
Twin Superchared Lightning part 1. To see it run, check out the "part 2"
link on this same page.
2014 Ford F-150 SVT Raptor Top 5 Likes & Dislikes (Episode 6)
( http://www.TFLtruck.com ) The 2014 Ford F-150 SVT Raptor is a capable and
even useful pickup truck that can serve as an everyday drive. But it is far
from perfect. In fact there are a number of areas that need improvement.
In Episode 6 of of this long-term test of the 2014 Ford F-150 SVT Raptor,
Roman takes a look at the Top 5 things he likes about the new Raptor and of
course the Top 5 things that he dislikes.
The Ford F-150 SVT Raptor is one of the baddest trucks in the land. It can
tow 8000 pounds, seat 5 comfortably, haul all of your stuff and still race
across the desert at over 100 MPH is perfect air-conditioned comfort.
That's why we at TFLtruck choose the 2014 Ford F-150 SVT Raptor as our
first long term test truck. Usually truck manufacturers supply us with
pickups to test for a week at a time. We wanted to test the best selling
truck in the land for durability and reliability which meant buying a Ford
F-150. But not just any Ford F-150, the most powerful and the most off-road
worthy version that Ford builds.
Check us out on:
Facebook: ( https://www.facebook.com/tfltruck )
Twitter: ( https://www.twitter.com/tfltruck )
and check out our car videos on YouTube at:
The Fast Lane Car ( http://www.youtube.com/user/romanmicagearguy )
Twin Supercharged SVT Lightning part 2
The Video speaks for it self.
Megafactories Ford F150
The One With The 2013 Shelby Ford F-150 SVT Raptor! - World's Fastest Car Show Ep. 3.20
Does a truck need a supercharged engine capable of producing 575 hp?
Probably not, but Justin has never been one to let rationality get in the
way of a little fun. So, he jumped at the chance to get behind the wheel of
the 2013 Shelby Raptor. Naturally, this truck of extravagant excess calls
Sin City its home, so Justin traveled to VORE (Vegas Off-Road Experience)
for a little fun in the sun.
World's Fastest Car Show appears every Friday on the Motor Trend channel.
Subscribe now to make sure you're in on all the action!
Facebook - https://www.facebook.com/WorldsFastestCarShow,
Twitter - http://twitter.com/motortrend &
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Google+ - https://plus.google.com/1018679678590...
Website - http://www.motortrend.com
Ford F-150 SVT Raptor: supercharged 600 hp POV test drive review (100+ mph & dyno)
http://www.POVtestdrive.com - Dyno proven horsepower! What is it like
to get behind the wheel of a supercharged 2014 Ford F-150 SVT Raptor owned
by NFL Superbowl Champion Evan Dietrich-Smith? Thanks to a massive whipple
Supercharger, livernois head/cams
assembly, and a snow performance methanol injection kit, this stock block
2014 SVT Raptor put down 604 wheel horsepower on 93 octane! Now
that's Ford Tough at over 100 miles per hour.
Learn more about Evan Dietrich-Smith:
Special thanks to Vortex Motorsport:
Subscribe: http://www.Boostaholics.com
2002 Ford F-150 Harley Davidson Supercharged Start Up, Exhaust, and In Depth Tour
In this video I give a full in depth tour on a 2002 Ford F-150 Harley
Davidson Supercharged. I take viewers on a close look through the interior
and exterior of this truck while showing details, over viewing of features,
and noting unique styling cues to the vehicle itself. I also show the
engine and the details of it, start it up and see how it sounds under
acceleration. A thorough review of this unique truck designed to give
others a greater overall appreciation of the vehicle.
Ford f 150 Raptor Тест-драйв.Anton Avtoman.
https://vk.com/antonavtoman Добавляйтесь в друзья!)
Ещё Пикапы
Ford f 150 Raptor Тест-драйв.Anton Avtoman.
1927 Ford: Double-Trouble -- /BIG MUSCLE
• Gordon Tronson
In the world of hot-rodding there are few cars that are going to leave as
big an impression as this - the 1927 Ford Model T custom simply known as
"Double-Trouble". It rides on a custom-built tube chassis that's fabricated
from 1.5-inch tube. Is powered by two 4.6-liter modular V8s from Ford with
four, count 'em, FOUR Superchargers for
an approximate power output of around 1,200 hp. It also utilizes the
rear-end (inboard disc brakes and all) from an early Jaguar. It's a rolling
a Hot Wheels car and a masterpiece of engineering that is sure to make all
your naughty bits tingle.
1969 Camaro SS Twin Turbo Supercharged Nitrous Breathing Monster
A 1969 Camaro SS with
Twin turbos and a Super Charger...and a
200 shot of Nitrous..Horse power is
unknown...but it is the most over the top Car I have ever seen...very
cool...check it out!! to see more of this car please visit
0-200 in 26 seconds in a Corvette
Lingenfelter corvette goes 0-200 in 26 seconds. This is grasshopper106's
car i claim no rights to it, however I was given full permission to keep
his videos up on my channel.
Engine removal & removal of intake manifold, cylinder heads, camshaft
-CNC porting & polishing of cylinder heads for optimal flow
-multi-angle valve job & surfacing for 11.5:1 compression
-Ferrea high performance dual valve springs, titanium retainers & valve
-Z06 GT21 camshaft by Competition Cams
-High Flow C6 Z06 Air induction & 4" diameter Mass Air Sensor
-Port Matched LS7 intake Manifold
-Ported and polished LS7 throttle body
-Higher capacity LS7 fuel injectors
-GM Head gaskets & head bolts
-160 degree thermostat
-Professional engine assembly and degreeing of camshaft
-Professional engine installation,testing & tuning
-American Racing Long Tube Headers
-Corsa Exhausts
-Exedy Twin Clutch
Just added the Fast Intake and 373 Gears.
70 Double Blown GTO
My 1970 GTO with two blowers. It's 474ci Pontiac engine with a 8-71 blower
on top of a 6-71 blower. This is from the last day of being double blown.
I'm going to one single 8-71 blower and going racing. The front clip was
removed to make it easier to work on. The reason for the double blowers was
not as a power enhancement like many ASSume. I stacked the blowers to have
a car that stood out in the crowd. Most Pro Street cars were starting to
blend together. If you seen one, you had seen them all. That wasn't the
case with this GTO. Al someone had to say was "The double blower GTO" and
people knew which car. I was told it couldn't be done, so I attempted it
and it worked. It stayed that way for almost 2 years. I knew a twin turbo setup would make more HP. I knew I could
have run a 14-71 blower and made more power. That wasn't the point. I
wanted to be different than the other cars in the parking lot, I did that
now it's time to ove on. For all those people who don't understand why,
I'm not going to try and explain it to you anymore. Get over it. I didn't
expect EVERYONE to love it. But you won't forget it.
2013 Ford F-150 Raptor SVT Supercab pickup truck - Offroading video
Ford wasn't expecting to sell many copies of the F-150 SVT Raptor when the
souped-up pickup was introduced for the 2010 model year, but the truck's
combination of off-road ability and reasonable on-road manners have made it
a surprise hit. More than 28,000 have been sold. Autoweek road test editor
Jonathan Wong takes us underneath the 2013 Ford F-150 SVT Raptor to show us
what sets it apart from the basic F-150 -- then runs it through a rugged
off-road course to demonstrate its all-terrain chops.
More on trucks (and cars, of course) at http://Autoweek.com.
Ford F-150 SVT Raptor em Detalhes (Canal Top Speed)
Se Inscreva no Canal para avaliações automotivas semanais e dicas:
Nesse Vídeo mostramos com mais detalhes, a F-150 SVT Raptor, a versão
esportiva off road da Ford.
[Top Speed]
WebSite - http://www.canaltopspeed.com.br
Loja - http://www.topspeedstore.com.br
FanPage - http://facebook.com/canaltopspeed
Instagram - http://instragram.com/canaltopspeed
Twitter - http://twitter.com/canaltopspeed
Lamborghini Aventador Twin Turbo Startup, Sounds, Acceleration, vs McLaren MP4-12C
Lamborghini Huracan vs McLaren MP4-12C Spider
McLaren 650S vs MP4-12C on the Dyno
GoPro Winner for October 2014 is Brad with a 2007 Volkswagen GTI
Which car is faster?
Similar 1/4 mile timeslips to browse:
2000 Ford F150 Harley Davidson: 7.655 @ 178.520
Craig Cain, Engine: 380, Supercharger: F2 Procharger
1998 Ford F150 Supercharger: 11.701 @ 119.000
Justin Maddox, Engine: 5.4 L triton V8, Supercharger: Paxton Turbos: turbos r 4 bumble bees Tires: hoosier street legal slicks
2011 Ford F150 Roush f150: 11.800 @ 114.630
Henry Ocasio, Engine: 5.0 Coyote, Supercharger: Roush phase 3
1999 Ford F150 turbo V6: 11.826 @ 119.000
rj beattie jr, Engine: ford 6 cylinder, Turbos: garrett Tires: GENERAL
2012 Ford F150 XLT Supercrew 4x4: 12.022 @ 115.195
mechanicboy, Engine: 5.0, Supercharger: Magnuson TSV1900 Turbos: N/A Tires: 275/60R17
2012 Ford F150 XLT SuperCrew 4x4: 12.313 @ 112.216
mechanicboy, Engine: 5.0, Supercharger: Magnuson TVS1900 Turbos: n/a Tires: Stock Michelins LTX A/T2 265/70r17
2007 Ford F150 Super Cab XLT Whipple: 12.460 @ 108.980
Jason, Engine: 5.4 3V Stock, Supercharger: Whipple Tires: 235/70/17 Front. 325/45/17 M&H rear
2004 Ford F150 XLT: 12.698 @ 106.460
Justin Meyers, Engine: 5.4L, Supercharger: Saleen Blower Turbos: N/A Tires: 295/45/20 Grabber UHP, 28x10/17 Hoosier Slicks on
1993 Ford F150 flareside: 12.720 @ 115.000
gary, Engine: 408 windsor, Tires: wore out 295/50 street tires
2007 Ford F150 XLT Extended Cab : 12.760 @ 106.620
Jason Barker, Engine: 5.4 3V Stock, Supercharger: Whipple 2.3 Tires: M & H Racemaster
2012 Ford F150 4x4 CrewCab: 12.874 @ 103.440
Greg, Engine: 3.5TT,
1999 Ford F150 XLT Kenne Bell and Nitrous: 13.178 @ 107.860
Joe Turbo, Engine: 5.4L, Supercharger: Kenne Bell
2012 Ford F150 Fx2: 13.280 @ 102.000
Ecofx86, Engine: 3.5, Turbos: twin Tires: Stock
2002 Ford F150 Lightning: 13.356 @ 103.450
Chris, Engine: 5.4L, Supercharger: Stock
2007 Ford F150 XLT: 13.390 @ 102.960
Jason Barker, Engine: 5.4 3v, Supercharger: Whipple
2002 Ford F150 Harley Davidson: 13.481 @ 100.530
l8tapex, Engine: 5.4, Supercharger: stock Tires: Stree Perelli
2011 Ford F150 XLT Ecoboost: 13.559 @ 101.320
TyRell Jones, Engine: 3.5, Turbos: Stock Borg Warner Twin Turbo
2011 Ford F150 XLT Ecoboost: 13.590 @ 98.770
Fritz Geiger, Engine: Stock 3.5, Turbos: Stock
1990 Ford F150 extended cab: 13.645 @ 96.410
Chuck Chatsko, Engine: 393,
2005 Ford F150 Lariat Crewcab 4X4: 13.665 @ 100.400
Matt, Engine: 5.4, Supercharger: Roush Turbos: N/A Tires: 275/65/18
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dude don't go down on amgina
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