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Monday, November 15, 2010
Barbara L. Duffy, 91
Barbara L. Duffy, 91, of Davie, Fla., formerly of Westport and wife of the late Cornelius F. Duffy Jr., died Nov. 16, 2010, at the North Broward General Hospital in Florida.
Barbara Duffy: 60-year Westport resident. Contributed photo
Born on March 18, 1919, in Nashua, N.H., she lived in Westport for 60 years before moving to Florida in 2004. She worked for Norwalk Hospital as a registered nurse for 32 years before retiring in 1991.
She had served in the U.S. Army Nurse Corps during World War II as a second lieutenant. She is a graduate of St. Joseph School of Nursing in New Hampshire and a life member of the Joseph J. Clinton Veterans of Foreign Wars Post 399.
Survivors include two sons, Richard F. Duffy and Daniel P. Duffy, and two daughters, Patricia F. Duffy and Kathleen E. Duffy all of Davie, Fla.; a grandson, Brian Duffy of Milford. In addition to her husband, she was predeceased by a son, Kenneth Duffy, and a grandson, Darrell Duffy.
Friday, November 12, 2010
Jane Turner Terpening, 88
Jane Turner Terpening of Westport passed away on Nov. 10 at the Honey Hill Rehabilitation Center in Norwalk. She was 88.
Jane Terpening: active at Unitarian Church. Contributed photo
Mrs. Terpening was born on May 15, 1922, the daughter of William and Grace Turner. Jane graduated from Phoenix High School and Oswego State Teacher's College.
She taught for more than 10 years beginning in a one-room schoolhouse in Booneville, N.Y., then to a class of 30 ninth graders in Rochester, N.Y.
She was instrumental in introducing a drug program in Westport during the 1970s called Project Renaissance, an offshoot of Daytop Village. She served for five years on its board of directors.
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Thursday, November 11, 2010
John C. Donaher Jr., 78
John C. Donaher Jr., of Fairfield, husband of Susan Sherman Donaher, died Nov. 9. He was 78.
Born July 18, 1932, in New Kensington, Pa., he graduated from the University of Notre Dame in 1954, with a B.S. in business, and in 1960 earned a master's degree in hospital administration from the University of Pittsburgh. A veteran of the U.S. Army, he served at the Allied forces headquarters in Paris from 1955 to 1957.
He moved to Fairfield in 1978 from Detroit, Mich., where he had been president of the Detroit Medical Center, to assume the presidency of Doctors Hospital in New York City. In 1990, he was appointed director of hospitals for Aga Kahn in Chantilly, France. He returned to Fairfield upon his retirement. He was a member of St. Luke Catholic Church in Westport.
In addition to his wife, he is survived by his sons John of Pittsburgh, Pa., Matthew of Newtown, and Patrick of Fairfield; daughters Tracy of Fairfield and Brigid MacDonald, of Hopkinton, Mass.; siblings Mary Ann Hanna, Ursula Donaher, Catherine Julien and Dennis Donaher all of Webster, N.Y.; 12 grandchildren, and nieces and nephews. He was predeceased by his parents, John and Margaret Donaher, and brothers William and Terrence.
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Mary Lee Culver Casson, 78
Mary Lee Culver Casson of Westport, a singer and actress, died Oct. 31. She was 78.
Born on Feb. 21, 1932, in Richmond, Va., she received a B.A. degree from Bryn Mawr College in 1953, and attended Juilliard School of Music in New York City and the Conservatorio de Santa Cecilia in Rome where she studied opera performance. She performed in musical theater productions and concerts.
She also acted in movies, including "Under Ten Flags" with Charles Laughton and "Five Branded Women" with Sophia Loren. She starred in the first full-length movie made for Italian television and had her own radio program.
After moving to New York City, she performed on stage and television, including commercials. She sang concerts at Carnegie Hall and other venues, and performed as the Angel in the Christmas show at Radio City Music Hall.
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Mary C. Fusco, 95
Mary C. Fusco, 95, a longtime Westport resident and wife of the late Patrick Fusco, died Nov. 6, at the Notre Dame Convalescent Home in Norwalk.
Born on Feb. 3, 1915, in Providence, R.I., she was the daughter of the late Gerald and Mary (Gallasso) Rubiano and had been a resident of Westport most of her life.
She was formerly a volunteer at Norwalk Hospital and the Catholic Daughters of America, Court Assumption.
Survivors include two sisters, Carmella Vento and Antonetta Cretella, both of Westport; two nephews and three nieces. She was predeceased by two sisters, Frances D'Orso and Jane Klupzak.
A Mass of Christian Burial took place Wednesday at Assumption Church in Westport. Memorial contributions may be made to Notre Dame Convalescent Hone, 76 West Rocks Road, Norwalk, CT 06851.
Tuesday, November 09, 2010
Richard A. Terry, Sr., 88
Richard A. Terry, Sr, 88, longtime resident of Milford and beloved husband of the late Joyce Terry, passed away from a tragic accident in Westport on Saturday, Nov. 6.
Richard Terry Sr.: coached gymnastics Contributed photo
Son of the late Franklin and Elizabeth Goss Terry, he was born in New Haven on July 10, 1922. Dick served with pride and honor in the U.S. Army Air Corps during World War II. He graduated with a BA from Central Connecticut and earned his Masters at Southern Connecticut State University (SCSU).
Dick worked for the Milford Board of Education as a shop teacher of industrial arts for automotive and metal. Dick founded and coached the Milford gymnastics program and was most instrumental in bringing about the sport of gymnastics statewide for Connecticut.
Dick served as assistant coach for the University of Bridgeport and the SCSU gymnastics programs and was associated with many Olympians. He was an energetic and vibrant force in the world of gymnastics and gave so much of himself in all sporting activities.
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Monday, November 08, 2010
Mary C. Crutcher, 95
Mary Constance Bliss Crutcher, born June 5, 1915 in Scranton, Pa., to Helen Jones and Sydney R. Bliss, died Nov. 6 at The Virginian in Fairfax, Va.
Her grandfather, from Macclesfield, England, founded the Bliss Silk Throwing Company which had five mills in Scranton and the surrounding area. She attended Scranton Country Day School and graduated from Sarah Lawrence College.
She married James Wood Johnson Carpender in 1935 and had her oldest daughter, Constance.
In 1945 she married Lt. Commander William R. Crutcher (USN) gaining another daughter, Caroline, and later having Susan, Nancy and Marny. She was a member of NOW wives in Southern California and McLean, Va. and served as president at one time.
Thursday, November 04, 2010
Maria Izzo, 101
Maria Izzo, 101, wife of the late Luigi Izzo, passed away at home on Wednesday, Nov. 3 in the company of her family and just two weeks shy of her 102nd birthday.
Mrs. Izzo was born Nov. 22, 1908 in Cavallare, Italy daughter of the late Joseph and Elizabeth Pagliaro and has been a resident of Westport for 57 years.
She is a former member of the Catholic Daughters of America, Court Assumption. Her favorite pastime included cooking and spending time with her family.
Survivors include five daughters, Angelina Carusone and her husband Joseph of Anzio, Italy, Elizabeth Petretta and her husband (Rocco) of Westport, Josephine Bertoldo of Meriden, Antonia Prentice of Monroe and Ann Izzo of Westport; two sons, Anthony Izzo and his wife (Margie) of Tarheel, N.C., Joseph Izzo of Westport, 13 grandchildren, 17 great grandchildren and many nieces and nephews. Mrs. Izzo was also predeceased by six brothers and sisters.
Tuesday, October 26, 2010
Herbert C. Hartmann Sr., 94
Herbert C. Hartmann Sr., 94, of Westport and Jupiter, Fla., the husband of the late Grete Hartmann, died Oct. 25 at his son's home in Old Saybrook.
Born in Brooklyn, N.Y., he was the son of the late Henry and Jennie Hartmann and a longtime area resident. He attended Peter Stuyvesant High School in Manhattan.
He began his professional career working six years at Chase Bank, then five years at IBM.
He moved on to Fairchild Camera in Jamaica, N.Y., where he played a role in Jimmy Doolittle's "Thirty Seconds Over Tokyo."
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Shirley Yvonne Huston Young, 84
Shirley Yvonne Huston Young, a Westport resident many years, died Oct. 18 in Wilton. She was 84.
Born on June 9, 1926, in Schenectady, N.Y., she was the daughter of Orrin R. and Blanche Gallant Huston of Scotia, N.Y.
She graduated Scotia High School in 1944, became a visiting nurse, married her husband, Richard Allen Young, in 1950.
In 1969, the family moved to Westport where she resided until 2000, then retired to Wallingford. She eventually moved to Wilton in 2006.
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Joseph C. Sibigtroth, 94
Joseph Clarence Sibigtroth passed away on Oct. 22 in Westport. He was 94.
Joseph C. Sibigtroth: World War II vet. Contributed photo
Born on Nov. 29, 1915 to Joseph and Alma Sibigtroth in Mendota, Ill., he was the second oldest of eight children, the others being Art, Helen, Ruth, George, Bernice, Don, and Bob.
He received his bachelors and masters degrees from the University of Illinois in 1939 and 1940, respectively. He married Marjorie Ward in 1941 and had two children, Alan and Joan.
From 1942 to 1946, he served in the U.S. Navy during World War II as a lieutenant in the southwest Pacific.
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Monday, October 25, 2010
Joseph Stein, Librettist of "Fiddler," Dies at 98
UPDATE Joseph Stein (r), the veteran musical librettist who penned the books to such shows as "Fiddler on the Roof" and "Zorba," died Sunday. He was 98 and had recently been hospitalized at Mount Sinai Medical Center in Manhattan after a fall. Stein visited the Westport Country Playhouse in 2007 (picture) when it held a benefit gala to honor composer John Kander (c), a partner in the musical theater songwriting team with the late lyricist Fred Ebb. The pair are best known for "Cabaret," "Chicago," and the song "New York, New York." At left is Stein's wife Elisa. Stein wrote the book to Kander and Ebb's musical take on Thornton Wilder's "The Skin of Our Teeth," called "All About Us," which had a production in Westport in 2007. The late Eartha Kitt, a Weston resident, appeared as The Fortune Teller. (CLICK TO ENLARGE) Phyllis Groner for WestportNow.com
Wednesday, October 20, 2010
Domenica "Mimma" Romeo, 69
Domenica "Mimma" Romeo of Westport, beloved wife of Orlando Romeo, passed away on Tuesday, Oct.19 at Yale-New Haven Hospital surrounded by her loving family. She was 69.
Domenica "Mimma" Romeo: longtime Westporter. Contributed photo
Domenica was born in Reggio Calabria, Italy on Feb. 12, 1941, and is the daughter of the late Andrea and Maria (Tegano) Galimi. She has resided in Westport for many years, working as a seamstress and homemaker.
She was a loving mother and grandmother, known to her grandchildren as 'Nonna'.
In addition to her husband of 47 years, she is survived by two sons, Carlo Romeo and his wife Katie of Fairfield, Andrew Romeo and his wife Luisa of Norwalk, two daughters, Maria Palmer and her husband Richard of Stamford, Julia Desroches and her husband Ron of Hamden, one sister, Maria 'Tita' Bellantoni and her husband John of Cos Cob, one brother, Ignazio Galimi and his wife Pina of Stamford, two sister-in-laws, Ada Galimi of Italy and Grazia Galimi of Norwalk, and 10 cherished grandchildren. She was predeceased by two brothers, Francesco and Antonio Galimi.
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Thursday, October 14, 2010
Ilse Barwick, 84
Ilse Von Lasser Zollheimb Barwick died Oct. 12 in Norwalk. She was 84.
Ilse Barwick: 30-year Westport resident. Contributed photo
She was born Dec. 24, 1925 in Austria, daughter of the late Eric and Elizabeth (Ferrous) Von Lasser Zollheimb. Her childhood and early education in Vienna was interrupted by the outbreak of World War II with the Russian advance in 1945.
The family was forced to flee and settled in the vicinity of Innsbruck, where she completed her studies at the local university.
After a brief period of employment with the U.S. Information Service in Innsbruck, she left for marriage to Aristide Hubrich in Zambia, Africa. They subsequently moved to London where two daughters were born.
Robert L. Weinstein, 76
Robert Lewis Weinstein of Weston passed away on Wednesday Oct. 13 at his home surrounded by his family after a serious illness. He was 76.
Mr. Weinstein was born in Brooklyn, N.Y., a son of the late Annette and Charles Weinstein.
Mr. Weinstein graduated from Hofstra University in 1956 with a degree in business. He was a member of the ROTC and spent six months on active duty stationed at Aberdeen Proving Ground and then another six years in the Army Reserves, moving up to the rank of captain before being discharged.
Throughout his life, he adored history and anything to do with the military.
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the only kind of Katie to be, a Katie Meyer. Est. January 25th 1988 Detroit Michigan. co founder of MeckBetta Productions (est. April 1st 2009)
katie meyer
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Select () or exclude () categories to narrow your recipe search.
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Find exactly what you're looking for with the web's most powerful recipe filtering tool.
1/1 Photo of Barbecued Chicken Wraps
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Excellent flavor and easy to make with 2 variations! The original recipe comes from Kraft I believe.
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Every recipe, menu, tip and how-to is right here, at your service.


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Friends Hotel
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Friends Hotel Georgetown
Travel Blogs from Georgetown
Hurrah for the British Commonwealth!
... city we had visited in South America - the 'Leave Arms Outside' signs at the corner shop didn't help to reassure us.
The most impressive building in town was the Anglican, Gothic-style cathedral, said to be the world's tallest wooden building?! Another prominent landmark was the cast-iron Stabroek Market with its clock tower dating back to the late 1700s.
Unfortunately, we just missed the CPL games being hosted in Guyana. However, Sophie was still ...
Kite Day
What an amazing day! We missed Easter Monday last year (locally also known as Kite Day) because we traveled back to Colorado for Leslie's dad's funeral. We made up for that today.
We made it to the East Coast Highway seawall shortly before 08:00. As you might imagine, there were very few people out at that hour. Regardless, it provided some fun photo opportunities. I think one of my favorites was the "Pristine Waters" sign on ...
Downriver to Parika
... of the 4Runner after our bout with the waves. I wound us through the streets of Parika and pointed back to the Harbour Bridge.
Approaching the bridge, I reached into my pocket to get money for the toll. I was surprised that heading east, there was no charge.
On the other side of the bridge I dropped off Elroy and Worren. Leslie, Pat and I continued our uneventful drive back to our homes.
... went to see the Cathedral, which was a little more run down than expected. Then we returned to the hotel for dinner. After we had finished eating, we were invited to join a trivia game, for charity. We said sure … and our competitors were not other guests at the hotel but rather four sets of expats and Georgetown elites who appear to be regulars. We were the only "first timers" … There were seven rounds, which was exhausting. we didn't win, ...
Diwali Motorcade
... stream of people walking alongside the floats, all heading to the conclusion at LBI.
The floats were stunning in both the lighting and the costumes of those on the floats. It was a very festive atmosphere.
Nearly every passing float had a young woman posed as Lakshmi. In each case, she was posed sitting on a full-bloomed lotus flower. Most of the women held up their right hand, palm facing forward. That position signifies that wealth can be ...
Other places to stay in Georgetown
Halito Hotel & Residence176 Middle Street, Georgetown | Hotelfrom $133
Pegasus Hotel GuyanaSeawall Road, Georgetown | 4 star hotelfrom $150
Cara Lodge294 Quamina St, Georgetown | 3 star hotelfrom $138
Herdmanston Lodge -- Guyana Hotels65 Peter Rose & Anira Streets, Georgetown | Hotelfrom $120
Princess Hotel Guyana InternationalPublic Road, Georgetown | Hotelfrom $148
The Eldorado Inn295 Thomas & Quamina Streets, Georgetown | Hotelfrom $70
Tower Hotel74 & 75 Main Street, Georgetown | 3 star hotelfrom $85


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Latest Headlines
Latest Headlines
Verizon lures new subs with $50 HBO, FiOS broadband bundle
Verizon is appealing to new potential FiOS subscribers with a new $50 video, broadband promotional bundle, but customers will need to be prepared for the price jump when the promotional period ends.
Analysis: Verizon wireline business 'lags' other providers
Even as management has "done some interesting things with FiOS services," Verizon's overall wireline business "lags the major wireline operators such as AT&T, Comcast and Cablevision," a Seeking Alpha analysis has concluded.
Verizon amplifies FiOS retention effort with My Rewards+ program
Verizon introduced a new loyalty plan earlier this year focused on adding value for FiOS customers called My Rewards+, an initiative designed to recognize a customer's service choice and provide rewards for certain behaviors. Now it appears that it's paying off.
Verizon touts 12 tuners with launch of FiOS Quantum video media servers
With the rollout of new home video gateways from Arris, Verizon is introducing FiOS Quantum TV as a new brand for its cable programming service.
Verizon claims NYC landlords are stunting FiOS rollouts
Verizon may see New York City as one of its key existing FiOS growth markets, but it claims that building owners are not letting the telco's crews install the service, reports The New York World.
Verizon grows California, Massachusetts FiOS footprint to 2.4M homes and businesses
Verizon may have no immediate plans to enter new markets with FiOS, but in existing markets like California and Massachusetts, the service provider extended the service to a total of 2.4 million homes and businesses in 2013.
Rural South Jersey communities: Verizon reneging on FiOS promise
Verizon is reneging on a two-decade-old pledge to provide broadband service to every New Jersey household, officials in rural Southern New Jersey claim.
Verizon extends FiOS to 3.7M more homes and businesses in Connecticut, New York
Verizon may have curtailed any new FiOS expansions, but in Connecticut and New York it continued to put the fiber to the premises (FTTP)-based service into the hands of more users, making it available to a total of 3.7 million homes and businesses in both states as of the end of 2013.
GreenWave Reality builds FiOS Quantum Gateway for Verizon
Verizon may be preparing to deploy a FiOS Quantum Gateway and Zigbee home automation module supplied by Irvine, Calif.-based GreenWave Reality, FCC test documents obtained by FierceCable indicate.
Verizon extends FiOS to nearly 1.3M Virginia homes
Verizon reported that as of the end of 2013, its FiOS network service was available to almost 1.3 million homes and businesses throughout northern, central and southeastern Virginia.


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A composition including a C terminal region having residues corresponding to a peptide identified by PDB ID: 1RG3; an N terminal region having residues corresponding to a peptide identified by PDB ID: 1RG4; and a disulfide linkage between the residues near the C terminal region and the N terminal region. A composition including an exogenous peptide comprising amino acid residues comprising a C terminal region; amino acid residues comprising an N terminal region; a helix-loop-helix conformation between the residues comprising the C terminal region and the residues including the N terminal region; and at least one disulfide linkage between the residues comprising the C terminal region and the residues including N terminal region, wherein the residues including the C terminal region and the residues comprising the N terminal region have an amphiphatic property, and wherein the peptide has an a biological activity comparable to native surfactant protein SP-B. A method including delivering to a body a composition comprising an exogenous peptide having a biological activity comparable to native surfactant protein SP-B. A kit including an exogenous peptide having a biological activity comparable to native surfactant protein SP-B; and a treatment agent different from the peptide.
1. An exogenous peptide comprising SEQ ID NO: 3.
2. A composition comprising an exogenous peptide of
3. A composition comprising an exogenous peptide of
4. A composition comprising an exogenous peptide of
5. A kit comprising an exogenous peptide of SEQ ID NO: 3 and an additional treatment agent.
6. The kit of
7. The kit of
8. A kit of
This application claims the benefit of the earlier filing date of U.S. Provisional Patent Application No. 60/573,171, filed May 21, 2004, and incorporated herein by reference.
This invention was made with Government support under Contract/Grant Nos. 008223-07, RO1 HL 55534, RO1 HL 51177 from the National Institute of Health (NIH), and TRDRP 11 RT-0222 from the Tobacco Related Disease Research Program of the University of California. The United States Government has certain rights in the invention.
Surfactants and uses thereof.
A surfactant may be described as a surface-active agent that lowers surface tension of water or saline. In biological systems, native surfactant provides maximum absorption that lowers surface tension and improves lung compliance. Surfactant is an essential substance for expansion of the alveoli, or air sacs of the lungs. Naturally occurring surfactants include several surfactant proteins (SP): A, B, C, and D. Proteins B and C are important because they enable the surfactant to adhere to alveolar surfaces. Surfactant Protein B (SP-B) is a critical protein to the activity of lung surfactant. SP-B as a component in surfactant is responsible for adsorption of the surfactant to the air-fluid interface, and therefore is necessary for optimum surfactant function.
A current use of surfactant supplements is in an endotracheal application to relieve respiratory distress. One condition that generally requires a surfactant supplement is neonatal respiratory distress syndrome (RDS). This condition may occur in prematurely born infants whose lungs have not yet completely developed. These infants typically do not have sufficient or properly functioning surfactant in their lungs that is required for normal lung function. Administration of a surfactant supplement may improve oxygenation and lung compliance. However, many surfactant supplements are derived from animal sources such as cow or pig lung lavage. These surfactant supplements have the potential of being contaminated with viral or prion-like components. Also, the use of surfactant supplements from native material tends to be expensive because of the limited amounts of natural surfactant that can be isolated from cow or pig lavage.
Adult (acute) respiratory distress syndrome (ARDS) may be described as the rapid onset of progressive dysfunction of the lungs, usually associated with the dysfunction of other organs due to the inability to take up oxygen. It is a catastrophic clinical syndrome that typically manifests as fulminant acute lung injury with diffuse bilateral pulmonary infiltrates, hypoxemia despite the administration of high concentrations of inspired oxygen, normal left ventricular end-diastolic pressure (as evidenced by a normal pulmonary capillary occlusion pressure), and reduced pulmonary compliance. Patients with acute lung injury typically have a mean alveolar oxygen pressure to fraction of oxygen in inspired air (PaO2/FiO2) ratio of less than 300 torr, while those with ARDS have a ratio less than 200 torr. According to these definitions, the difference between acute lung injury and ARDS is the degree of oxygenation abnormality. The condition is associated with extensive lung inflammation and small blood vessel injury in all affected organs.
Current treatment for ARDS consists of mechanical ventilation along with careful attention to fluid balance and a supportive breathing technique called positive end expiratory pressure (PEEP). These are combined with continuing treatment of the precipitating illness or injury. Most ARDS treatments do not involve surfactant replacement therapy. Even if the ARDS is cured by current treatments, a study found that survivors may have persistent functional disability one year after discharge from the intensive care unit, most commonly reflected in muscle wasting and weakness.
The predominant risk factors for the development of ARDS are sepsis and Systemic Inflammatory Response Syndrome (SIRS), acid aspiration, trauma (especially with long bone fractures, chest wall injury, lung contusion), multiple emergency transfusions, prolonged hypotension and shock, burn injury, pancreatitis, and post-cardiopulmonary bypass. These clinical conditions may identify a population of patients who are at increased risk of developing acute lung injury; however, there is no definitive test or marker that will signal patients who are at the highest risk for developing the syndrome.
The conventional management of a patient with acute lung injury has primarily been one of support. Despite a multitude of experimental animal studies and human clinical investigational trials, no specific therapy for the prevention or treatment of acute lung injury has yet been identified. At the present time, the only specific therapy is the identification and prompt treatment of the underlying pre-disposing cause of the lung injury.
It appears that the ventilatory management strategy may have a direct impact on the outcome of patients with ARDS. However, there is still a significant mortality despite this improvement with ventilatory management. Alternative therapies are necessary.
New approaches to management are under evaluation and several have shown promise. The past 30 years has seen a number of clinical trials to evaluate potential treatment strategies for patients with ARDS. Some of these approaches involved new strategies for ventilatory management such as the use of extracorporeal membrane oxygenation (ECMO), high frequency ventilation, low frequency ventilation, permissive hypercapnia, inverse ratio ventilation, airway pressure release ventilation, and even prone ventilation. Other innovative therapies include early high dose corticosteroids, platelet activating factor antagonists, prostaglandin E1, inhaled nitric oxide, surfactant replacement therapy, antioxidant therapy, partial liquid ventilation, and the use of nonsteroidal anti-inflammatory agents. Despite an improved understanding of the potential pathogenesis and improvements in technology, there has not been a demonstrated benefit attributable to these new treatment strategies.
The most common cause of death in patients with ARDS continues to be from multiple organ failure and recurrent sepsis. Less than 20 percent of patients die because of the inability to adequately oxygenate or ventilate the patient. The complexities of the balance between the pro- and anti-inflammatory processes that encompasses the pathophysiologic response of this injury directs the response from organ dysfunction secondary to an overzealous pro-inflammatory reaction to infectious complications that result from the immune suppression of a predominant anti-inflammatory response. When infection is present, the lung is a frequent site for the process and may be extremely difficult to diagnose.
The embodiments herein include compositions and methods to administer a treatment agent to the lungs of patients or as scientific tools to, for example, study the role and metabolism of surfactants in biological systems. In one embodiment, a composition is described that is capable of mimicking the Surfactant Protein B of lung surfactant. In another embodiment, a method is described to increase the compliance of the lungs by introducing a surfactant agent to the lungs including a composition of an exogenous SP-B peptide or construct (e.g., �Mini-B�).
In other embodiments, an exogenous surfactant composition described herein may be used as an adjuvant for delivery of other treatment agents. For example, an exogenous surfactant composition may be used to deliver antibiotics, steroids, growth factors, vaccine, hormones, etc. to the lung. In another example, an exogenous surfactant composition may be used to deliver genetic material to the lungs for treatment of a condition.
In some embodiments, an exogenous surfactant (alone or as an adjuvant) is delivered via a single volume or a multiple of small volumes to the region. These delivery methods may use imaging of the lung to guide the deposition of the treatment agent to the site of the deficiency such as deposition of the composition via a delivery capsule or particle. In other embodiments directed to the treatment of surfactant deficient conditions or agent delivery, the composition may be introduced via an inhalant or injection.
In another embodiment, a method includes multi-component treatments of the lung including but not limited to the introduction of other existing surfactant treatments.
In one embodiment, the treatments may occur at any time after recognition of a surfactant deficiency condition or other identified condition. In another embodiment, the treatments proposed may occur prior to a surfactant deficient condition or identified condition if an occurrence is suspected to precipitate without treatment.
In a further embodiment, a kit is disclosed. One example of such a kit is a kit including a composition that may be introduced to the lung region directly.
The following drawings form part of the specification and are included to further demonstrate certain aspects of the claims. The claims may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.
In one embodiment, a construct or peptide is described that mimics the activity of Surfactant Protein-B (SP-B). In another embodiment, a SP-B-like construct (peptide) referred to herein as �Mini-B construct (or peptide)� may be generated. In yet another embodiment, a composition including a Mini-B construct may be used as a treatment agent to, for example, treat subjects suffering from RDS or ARDS. In still yet another embodiment, a composition including a Mini-B construct as a co-treatment agent with another treatment agent, or as an adjuvant for another treatment agent, may be used in a treatment protocol. In a further embodiment, a Mini-B construct or composition including a Mini-B construct may be used as a scientific tool.
A Mini-B construct (peptide) at the Protein Data Bank is available at the NIH-NSF sponsored Protein Data Bank website and corresponds to accession code: PDB ID: 1SSZ http://www.rcsb.org/pdb/cgi/resultBrowser.cgi?PDBId::PDBId=1SSZ&fromSE=1.
In one embodiment, a Mini-B construct or peptide is a disulfide stabilized 34 residue cyclic construct (peptide) that emulates the in vivo and in vitro structure and activity of a full length 79 residue SP-B native protein in lung surfactant lipid dispersions. A Mini-B construct mimics the N-terminal and C-terminal amphipathic domains of the parent protein that are believed to be the active site of interaction of the protein with surfactant lipids. In one embodiment, a Mini-B construct has the same sequence and disulfide connectivity that constrain the peptide into the active conformation that resembles that of the full length native protein. By folding into this disulfide constrained, native like conformation, the Mini-B construct has a surface charge distribution allowing it to interact with surfactant lipids similar to that of the full length native protein.
The Mini-B constructs described herein are exogenous in the sense that they are derived or developed from outside a body. Examples of exogenous constructs are those derived from synthetic or recombinant techniques. The exogenous constructs tend to have a longer shelf life and are more cost effective than native derived preparations. Further, the exogenous nature of a Mini-B construct minimizes the potential for contamination from viruses or prions that may be associated with native material (e.g., surfactants derived from cow or pig lavage).
The Mini-B constructs described herein have very high activity compared with other currently available surfactant supplements and in combination, for example, with exogenous (e.g., synthetic) surfactant lipids may be formulated to work with a number of lung-related applications such as RDS and the delivery of drugs and/or genetic material.
In one embodiment, Mini-B constructs were designed based on the amino acid sequence and disulfide folded N-terminal and C-terminal linkage observed in human Surfactant Protein-B (SP-B) and most proteins in the saposin family to which lung surfactant proteins belong. Representatively, a Mini-B construct has the same sequence as that observed for residues 8 to 25 of the N-terminal mature protein domain that is jointed to the C-terminal domain of the parent SP-B protein residues 63 to 78 as a single linear 34 residue sequence.
Referring to
In the example described with reference to
The disulfide linkage(s) observed for many of the members of the saposin protein family, serves to constrain the Mini-B construct into a compact amphipathic helix-loop-helix (�helix hairpin�) conformation that improves the interaction of the Mini-B construct with surfactant lipids to yield in vitro and in vivo activities similar to those observed for the native full length, 79 residue protein. In vivo and in vitro activity of a Mini-B construct is conserved where the construct has only a single disulfide linkage between Cys-1 and Cys-33. In other words, it has been demonstrated that a second disulfide linkage between Cys4 and Cys-27, when either blocked by a protecting group such as with Acm or mutated to another similar amino acid such as the Cys surrogate (e.g., alanine (Ala)), does not significantly affect the activity of the construct. This suggests that an important element may be the formation of the folded cyclic-like conformation stabilized by the oxidation of the Cys-1 and Cys-33 disulfide linkage. Thus, in another embodiment, a Mini-B construct, has (1) only a single disulfide linkage at Cys-1 and Cys-33 or (2) a disulfide linkage between residue of the C-terminal region of the construct and a residue of the N-terminal region of the construct and either no other disulfide linkage or one or more disulfide linkages that are not between residues across the fold.
In humans, the composition of native lung surfactant is lipid (approximately 90 percent to 97 percent) and various proteins (approximately 10 percent or less) including SP A, B, C, and D. A primary lipid is a phospholipid, principally a phosphatidyl choline (PC) (saturated lipids) and less significantly a phosphatidyl glycerol (PG) (unsaturated lipids). The primary PC lipid is dipalmitoyl phosphatidyl choline (DPPC). The majority of the surfactant lipids are anionic (DPPC is a zwitterion having both positive and negative charges).
The three dimensional structure of native Surfactant Protein B is not yet known. Certain structural properties have been hypothesized including a predominantly amphipathic helical motif of Surfactant Protein B having a cluster of cationic charged amino acid residues in the disulfide linked N-terminal and C-terminal domains of the full length protein. It is believed that the cationic charged amino acids interact with surfactant lipids (e.g., with amionic lipids). A Mini-B construct includes an amphiphatic helical motif having a cluster of cationic charged amino acids that folds into a secondary and tertiary structure (including a saposin-like fold) that emulates that predicted for the full length protein. The structurally similar Mini-B construct has in vitro surface activity and emulates mechanistic changes in the molecular topography surfactant lipid dispersions as that observed for the native protein. In vivo activity of the Mini-B construct shows oxygenation and dynamic compliance that compares on a molar basis with the native SP-B protein. However, substitution of polar uncharged residues for cationic residues in the Mini-B construct resulted in a similar structure but greatly attenuated surface activity, altered molecular topography and poor in vivo activity in animal model systems. These findings suggest that the unique charge distribution of the disulfide linked N-terminal and C-terminal domains of SP-B are at least one of the major components for optimal function of the protein in surfactant lipids.
The overall secondary structure of a Mini-B construct has been examined using Circular Dichroism (CD) and Fourier Transform Infrared (FTR) (
The structure of a Mini-B construct presented here was resolved using isotope enhanced FTIR. Based on experimental data, the molecular coordinate set was refined using molecular dynamics and mechanics in the Insight II environment with the CHARMM� force field (a scientifically accepted software package used to refine experimental data to solve a three dimensional structure of a protein).
The overall conformational estimates of a Mini-B construct from CD and FTIR compare well with those percentages determined by predictive neural network algorithms (e.g., Predict Protein, http://cubic.bioc.columbia.edu/predictprotein/) based on the crystal (Saposin B, PDB ID: 1N69), NMR structures (NK-Lysin, PDB ID: 1NKL; Saposin C, PBD ID:1M12), and the isotope enhanced structure for the N-terminal segment of SP-B in surfactant lipids (SP-B1-25, PDB ID: 1DFW). Based on structural data and known structures from the Protein Data Bank, a proposed structure for the Mini-B construct is shown in
Helical domains were predicted for a Mini-B construct and reveal the presence of an anti-parallel sheet in the mid-sequence bend domain (
Molecular modeling of secondary structure assignments templated on Protein Data Bank structures of SP-B1-25(PDB ID: 1DFW) and NK-Lysin (PDB ID: 1NKL) and SAPOSIN B (PDB ID: 1N69) were conducted by molecular dynamics and energy minimization to optimize the protein structure geometry. The results of modeling reveal 15 helical residues or 15/34=44% helix, 8 to 10 random residues or 10/34=29 random, 5 loop or turn residues or 5/34=15% turn.
The optimized structure indicates that the amount and location of helical structure elements is similar to that observed from the experimental measurements of the peptide using CD and FTIR techniques. Predicted secondary structural assignments of the amino acid sequence for a Mini-B construct were based on the neural network Predict Protein program, Ph.D.
Isotope enhanced 13C carbonyl labeling of the amino acid residues in the N-terminal, mid, and C-terminal segments of the construct confirmed the residue specific helical elements in the N- and C-terminal domains and assigned turn and beta sheet elements to the mid-sequence. This structure in turn gives the correctly folded peptide a surface charge distribution that is similar to native SP-B lipid interaction domain that improves the surfactant lipid interaction function.
In one embodiment, a composition including a SP-B-like construct (e.g., a Mini-B construct) may be used to target delivery of the SP-B mimic or another agent to the lungs of a subject. In another embodiment, a composition including at least one SP-B-like construct (e.g., a Mini-B construct) may be used to target delivery to the lungs of a subject with RDS (or ARDS). One delivery mechanism is via an inhalable composition. An inhalible composition may include a liquid such as a fine mist or dry powder where the composition is encapsulated or free-flowing. The encapsulated composition may include one or more lipids (e.g., phospholipids) and/or other peptides and/or proteins necessary to treat a condition such as a lung condition including asthma.
As noted above, a composition including a Mini-B construct may be combined with lipid(s). Representatively, such lipid(s) may be of the type that are associated with lung surfactant. In one embodiment, a synthetic lipid dispersion was developed that mimics native surfactant lipid. In one embodiment used in Examples 1-3 herein, the dispersion (�ISPL�) includes 35 mg lipids/ml 150 mM phosphate buffer saline solution (16 mg/ml dipalmitoyl phosphatidyl choline (DPPC), 10 mg/ml palmitoyl-oleoyl phosphatidyl choline (POPC), 3 mg/ml palmitoyl-oleoyl phosphatidyl glycerol (POPG), 1 mg/ml palmitoyl-oleoyl phosphatidyl ethanolamine (POPE), 3 mg/ml palmitoyl-oleoyl phosphatidyl serine (POPS), and 2 mg/ml cholesterol). ISPL simulates the native cow/calf lipid dispersion of INFASURF�.
A composition including a Mini-B construct may also serve as an adjuvant and may accompany a therapeutic agent. In this manner, the lung may serve as a conduit to deliver drugs (e.g., antibiotics), growth factors (e.g., fibroblast growth factor (FGF), erythropoietin (EPO)) or other biomolecules (e.g., peptides, proteins), vaccines, hormones (e.g., insulin), etc. to the systemic circulation. One advantage to this conduit is that the vascular network associated with the lungs may provide rapid systemic delivery of a treatment agent. A Mini-B construct functions similar to native surfactant B and thus can provide access, perhaps in the presence of a lipid (e.g., a synthetic phospholipid), of a treatment agent to the lungs. In one example, a composition such as a composition including a Mini-B construct may coat the outside of a microsphere carrying a treatment agent (thus directing the composition to the lung inner surface). In another example, a composition including a Mini-B construct may be harbored within a delivery vehicle such as a microparticle and then released at a predetermined rate during or after delivery has occurred for the composition.
In another embodiment, a composition containing at least one SP-B-like construct (e.g., a Mini-B construct) may be used to target meconium aspiration syndrome (MAS) in full-term newborns. MAS is a consequence of improperly expelled waste products from the gastro-intestinal tact that may occupy a newborn subject's lungs at birth, causing breathing difficulties. This disorder is characterized by the presence in the lungs of meconium, inflammatory cells, inflammatory mediators, edema fluid, protein and other debris. Inhaled meconium can inactivate a newborn's own natural surfactant.
As noted above, surfactant supplements are known. INFASURF� (calfactant) is an intratracheal, non-pyrogenic lung surfactant supplement intended primarily for intratracheal instillations. It includes an extract of natural surfactant from calf lungs that includes phopholipids, neutral lipids, and hydrophobic surfactant-associated proteins B and C. In another embodiment, a composition including a Mini-B construct may be used in conjunction with a surfactant supplement such as INFASURF�, either in a combined composition or consecutively administered compositions. A representative treatment is for RDS and ARDS.
An embodiment of a Mini-B construct may also serve as a scientific tool. Representatively, a Mini-B construct may be used to study the role and metabolism of surfactants in biological systems.
In still further embodiments, any of the embodiments of a Mini-B construct described may form a portion of a surfactant replacement or supplement kit for use with the methods described above. As the encoded proteins or peptides may be employed to treat a condition and the corresponding peptides may be employed to replace missing components or deliver an agent. The kits will thus comprise, a suitable container means, a peptide (e.g., a Mini-B construct), and/or an agent (e.g., antibiotic, genetic material). In other embodiments, the Mini-B construct may be combined with any other known therapy such as oxygen supplements or anti-inflammatory agents.
The kits may further include suitable aliquots of a construct composition for administration. These aliquots may include daily amounts for a single dose or multiple dose aliquot package separately for administration several times daily.
Suitable containers of the kits will generally include at least one vial, test tube, flask, bottle, syringe or other container, into which the construct composition may be placed, and preferably, suitably aliquoted. Where a second or third component (e.g., treatment agent) is provided, the kit will also generally contain a second, third or other additional container into which the component may be placed. The kits will also typically include a container for the construct composition, and any other component containers in close confinement for commercial sale. Such containers may include injection or blow-molded plastic containers into which the desired vials are retained.
Table I shows the similarity between a Mini-B construct and various other known SP-B sequences (taken from the ExPASy Molecular Biology Server: Swiss-Prot and TrEMBL:http://us.expasy.org/cgi-bin/sprot-search-de?Surfactant%20Protein%20B. Mini-B construct sequences are bolded from the full length sequence for clarity.
Table II shows a Mini-B construct compared to various species. Comparison of sequences between species shows that the amino acid sequences are highly conserved with few substitutions. Most substitutions are very conservative (amino acid substitutions underlined).
The in vivo activity of Mini-B in the rat RDS model system exceeds that observed for native pig SP-B in synthetic surfactant lipids (
Further in vitro surface activity studies of a Mini-B construct in vitro surface activity using Langmuir trough and surface pressure dependent changes in peptide-lipid film microstructure also suggest that a Mini-B construct has a mechanism of action similar to that of the native SP-B protein.
Surface shear viscosity measurements of a Mini-B construct in a simulated INFASURF� lipid dispersion ISPL (cow lung lavage lipids) is represented in
Langmuir trough measurements of a Mini-B construct in ISPL lipids are represented in
Brewster Angle Microscope images of monolayer surfaces of Mini-B-ISPL lipids versus lipids alone on the Langmuir trough as a fimcfion of surface pressure is represented in
Brewster Angle Microscope images of monlayer surfaces of Mini-B-synthetic cow lung lipids compared with the commercial surfactant preparation INFASURF� that contains native SP-B and SP-C proteins is represented in
Studies of the surface film isotherms of a Mini-B construct, native SP-B and commercial preparations of native proteins and lipids have very similar compression and respreading properties. Scanning electron micrographs of dispersions of simulated cow lung surfactant lipids used in in vitro and in vivo experiments in this application show specific morphological changes with the addition of a Mini-B construct (
In the preceding paragraphs, specific embodiments are described. It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the claims. For example, a Mini-B construct was described formed by a synthetic route utilizing particular C-terminal and N-terminal peptide portions available at the Protein Data Bank. It is appreciated that in one instance certain amino acids of these peptides may be substituted for others with similar properties. It is also appreciated that amino acids may be added to either of these peptides without modifying the properties characteristic of an SP-B protein. The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.
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Roatan Villa Rental Photos and Description
Villa and Cabana, 5 Bedrooms + Convertible bed(s), 8 Baths, sleeps 4-12
Find your private tropical retreat at Casa Vista Verde! This custom home brings together a beautiful private beachfront location, luxurious accommodations, and exceptional amenities to help create lifetime memories for you and your guests.
5 private bedrooms with full ensuite baths, a fully equipped kitchen with standalone icemaker, and state of the art media centers keep you comfortable inside. Outside, you'll find swimming, scuba diving, kayaking, snorkeling, fishing, windsurfing, and wakeboarding easily accessible with our deepwater pool, spa tub, cabana, 900 foot private beach, and 130 foot dock on crystal clear Caribbean water. Casa Vista Verde covers 8.5 landscaped acres on Milton Bight, a picturesque bay on Roatan's north shore, slightly east of the island center. Airport transportation, provisioning before and during your stay, and 6 days per week of housekeeping and day meal preparation are included with your stay. Visit Casa Vista Verde for the best Roatan has to offer!
Please visit our website at www.VistaVerdeRoatan.com for additional photographs, video, and rental details.
- Suitability:
- Events Allowed
- Long-term Renters Welcome
- children welcome
- pets considered
- smoking allowed
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About Asa Davis
I'm from Rhode Island, and while growing up spent as much time on the water as possible! My interests include scuba diving, boating, windsurfing, sailing, and fishing - if it involves the ocean, I probably like it. After spending years searching the world for the perfect location for this project, I decided on Roatan and this location on my first visit. I feel fortunate to spend time on such a beautiful island helping create exceptional vacation memories for our guests!
-Asa Davis, Owner
Asa Davis purchased this villa in 2005
Why Asa Davis chose Roatan
Before buying, I was looking for enough space to insure guest privacy; beach, waterfront, and boating activities worth the travel; construction of the highest quality; residents and government friendly to U.S. investment and tourism; and the chance to incorporate yachting service standards in our offerings. After searching most of the Caribbean and parts of the Pacific looking for the right spot, Roatan fit the bill perfectly!
Guestbook comments from the owner
My fiance and I came to Roatan to check out the island for our destination wedding. Roatan is beautiful and Vista Verde is the perfect location for our wedding. The house is gorgeous, the views are amazing and the staff wonderful. We can't wait to share this paradise with our friends and family! See you Fall 2015!


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Bill passes requiring more oversight of troubled DMR
by MBJ Staff
Published: March 12,2014
Tags: Bill Walker, Brice Wiggins, court, David Baria, house, Jeffrey Guice, justice, law, legal, Miississippi Legislature, misappriation, Mississippi Department of Marine Resources, Personnel Board, SCANDAL, Senate, Senate Bill 2579, state agency, state government, State of Mississippi
BILOXI — A plan to reorganize the scandal-plagued Department of Marine Resources (DMR) and require that it be audited every year is moving forward.
House members passed an amended version of Senate Bill 2579 Tuesday, returning it to the Senate for more work.
Rep. David Baria, D-Bay St. Louis, persuaded House members to amend the bill, taking out a provision that would have removed DMR employees from civil service protection for one year.
Baria argued current managers shouldn't be trusted with that authority, considering past mismanagement. Former DMR executive director Bill Walker pleaded guilty Monday in U.S. District Court to a charge of conspiring to defraud the federal government. Two other former DMR employees are under indictment.
"If there ever was an agency that needed to be held accountable, it is the DMR, considering what has gone on down there, and I don't believe it's appropriate to remove them from the protections of the state Personnel Board."
Supporters, including Rep. Jeffrey Guice, R-Ocean Springs, said they're confident in current leaders and say they should be allowed to freely reassign or fire employees.
"It's just dragging out the inevitable," Guice said of maintaining civil service protections. "I don't believe the purpose of getting out from under the personnel board is about firing people. It's about reassigning people."
The measure also sets requirements for the agency's chief financial officer, chief scientific officer and head of the state Marine Patrol.
The House version also removes a proposal by Sen. Brice Wiggins, R-Pascagoula, which would have abolished an account for the state artificial reef program. Wiggins said the state needed better oversight of that money, which was tied to Walker's conspiracy charges.
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Beyond Good & Evil 2 was destined for the next generation of consoles, and now Michel Ancel has shed some light on the issue. Speaking to GamesRadar, Ancel stated that the scope of the first Beyond Good & Evil was "large" – including "the city, the ocean, the moon and the space ship" – but it was originally intended to be much larger.
The space ship, said Ancel, was originally intended to travel to distant planets, but the limitations of PS2 era consoles hindered the game's vision. "My thing is that we really want to make the game that was previously imagined, with all this feeling of traveling," said Ancel, citing Mass Effect as a good example of the concept. The development team at Ubisoft hopes to "continue in that direction, with storytelling and a massive world," so much so that, apparently, current generation consoles just won't cut it.
Check out the full interview for more on the original Beyond Good & Evil, Rayman Origins and Ancel's development philosophy.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
I just picked up this car for 300 has 281,000k`s did a tune up replaced the alternator need to replace transmission fluid, and had to reattach the sub frame and steering. The car runs great and kicks but on the highway considering the high kms. I`m keeping this car til it dies completely then I`ll probably get another one and use mine as parts. I`ve seen these cars go up to 400,000k`s at the junkyard. overall amazing car would buy another one in a heartbeat.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
I bought this LeSabre when it had 30,000 miles on it. It now has 116,000 miles on it. I had the transmission rebuilt at 90,000 miles, replaced the alternator and replaced the spark plugs once. The car needs repainting, the disc brake pads and rotors need replacing, again, and the windshield needs replacing. But, I would buy this car again. I have had much worse cars.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
This car has the nicest ride of all I've ever got to own/drive! The only other nicer riding car I've driven was a Uhaul Chevrolet C1500 pickup truck. Unfortunately, it does have a few negatives. When I bought mine with 75k miles, it already had a constant misfire due to a or a couple of stuck fuel injectors. Because of this, the idle often gets too low when parallel parking effectively eliminating steering assist. Electrical system reconfigured itself at 115k. Car suddenly died, lights out, restarted a few minutes later but now lacking the function of radio(oddly tape plyr still works),AC, and manual interior lights (still works with door).
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1993 Buick LeSabre Sedan Limited 4dr Sedan
It's so comfortable to drive, roomy and reliable, that after 175k miles, I just can't convince myself to trade it in on something new. It's been absolutely reliable only breaking down once needing a new water pump. It's really nice on long road trips as the seats are like sitting in a Laz-E- Boy or something. Never had parts of my anatomy fall asleep or anything. Perfect carpool car as there is tons of room in the back seat for even the largest of adults. Gas mileage has been respectable averaging about 17-20 mpg in the city. I've had 3 carseats across the back seat for the last two years and there's plenty of room. Huge trunk for double stroller and all the other kid supplies.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
I bought my LeSabre for $3800 in 2001 after doing internet research on lasting vehicles. I have not been disappointed! It is so comfy that the first time I drove it, the kids fell asleep during the first 15 minutes and I nearly did, too! It had 96k mi. on it then, and it now has 185k. I've only had the fuel pump and struts replaced, a couple of alignments, and a $100 electronic part replaced twice. When I was looking into getting a new car, I decided I wanted a 2002, or newer, LeSabre. But they seem to have some neg. feedback, so I keep driving mine. I guess I'll replace the headliner and keep driving it until it stops running-if ever. With 22-24 mi/gal on trips, and room for six, I'm spoiled!
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1993 Buick LeSabre Sedan Limited 4dr Sedan
The car is very good in general. I have only two problems:the remote-controlled door and ABS stopped working right after passing 36,000 mileage, the warranty was just expired. I left these problems until now because of high repair cost. The engine is still very good until now, with mileage 252,600. I drove the car across the country at least 10 times. Air conditioning system still working very well in driving through desserts. If I do not have problem with the ABS and remote doors, I would definitely buy another Buick.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
I bought this car with 30,000 miles on
it in June 2003. With the V-6, the car
has performed very well and is very
comfortable for my 6 foot frame and my
wife's 5 foot frame. We take it on
long trips and it is very comfortable.
I project that the engine will go
nearly 200,000 miles but the
transmission is starting to show some
wear. I expect to have it rebuilt
arount 100k miles. A few chips in the
paint but that is expected. I will
refurbish this car or buy another like
it someday-after this one drops dead
because it is so reliable. For the
money, it cannot be beat.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
very good car,the next car I buy will be the same kind.very dependable car.
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1993 Buick LeSabre Sedan Limited 4dr Sedan
I purchased this car new from Frederick
Cadillac (then a Buick dealer) in
October 1993. I have had it serviced
every 3000 miles by Frederick's and
then Huling Buick when I moved to West
Seattle. I have all the service
records. The transmission has been
replaced and serviced as have the hoses
and any other recommendation made by
the dealer. The car has 106,000 miles.
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For new questions please post at magento.stackexchange.com, the community-run support site for the Magento community. We will be providing updates on the new forum solution soon. For questions or concerns please email firstname.lastname@example.com.
Hello every body; and sorry again and again for my bad laguage;
i have tried to update the grand total in shopping cart,
what i did is adding this code :
//the condition is to discount the price of the gift from grand total; it works when the gift product is alone in the shopping cart but when i add an other product to the shopping cart that condition doen't aplly!!!!
$price= $item->getProduct()->getPrice(); // $cat = Mage::getModel('catalog/category')->load((int)$current); foreach (( $item->getProduct()->getCategoryIds()) as $cat){ if ($cat == 138){ //Category gift $address->setGrandTotal(($address->getGrandTotal()+ $address->getShippingAmount())-$price); $address->setBaseGrandTotal(($address->getBaseGrandTotal() + $address->getBaseShippingAmount()-$price)); } else { $address->setGrandTotal(($address->getGrandTotal()+ $address->getShippingAmount())); $address->setBaseGrandTotal($address->getBaseGrandTotal() + $address->getBaseShippingAmount()); } }
hello enybody there??
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and evy help will be apriciate it thank you in advance.
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This representative example shows how anglers typically attached the Dacron line, wire leader and copper wire to the swivel during traditional live-bait fishing in Boca Grande Pass from 2002 to 2004.
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Hi, I've been reading about the solid surface tub surround kits, but does anyone knoe where I can find them (in L.A. area)? I checked Home Depot and they only have the acrylic ones. Thanks
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- Where to get solid surface tub surround kit?
Solid surface is a wonderful material but requires an 'expert' to install it correctly. It must be machined exactly to insure the joints will match and can be 'sealed' together. Don't think this is a good project for someone who does not have a lot of experience with the material.
Somewhere hereabouts, you posted the same question, and I posted an answer there. But I'll repeat it here. Home Depot inthe Greater Boston area sells Corian tub surrounds, although they don't keep them in stock. They're special order, and they can, indeed, be installed by the home owner with a little experience in home renovation. That's exactly what I did. The only really scary part came when I had to "cut" the tub surround at the bottom to fit the tub. Scary given the cost of the things. But the manufacturer provides some pretty explicit instructions and materials to make templates with.
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Where to get solid surface tub surround kit?
Where to get solid surface tub surround kit?
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Select () or exclude () categories to narrow your recipe search.
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I just made this up as I went along. I'm eating the very first one now. It's pretty good.
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vanilla-flavored soymilk
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Details: Half price all Iphone products.
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text:
the last 1,000 customers:
from CustomInk again
Uncensored Customer Reviews
Here's what recent customers had to say:
I will definitely recommend you and should I ever have need myself, I will be contacting you. These 6 hoodies were gifts from me to the family who suffered the loss of their loved one, "David".
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Custom made the whole process very easy . Everyone loves the tees and hoodies. Will be purchasing more REAL soon!!!
Adbrook Plastering and Drywall,
Danvers, MA
They moved the name to the opposite side of the hoodie. The logo didnt come out the way I wanted. I thought there was a gray highlight over the symbol. I didnt realize that there was going to be an actual gray square over the logo. Printing is nice though looks durable. There were some other things I wanted to do but that would have involved buying 6 hoodies, which is kinda lame. I think overall not bad I would order again.
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Rainbots JR Lego League,
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Awesome hoodies. Can't wait till our next order
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3d recon,


text:
Telephone & Addresses
(1 - 4 from 353
Anna Gardner (Age: 27)
47904 La Fayette IN
Anna Gardner
44114 Cleveland OH
Anna Gardner (Age: 29)
45036 Lebanon OH
Yellow Page contacts
Network Profiles
(1 - 4 from 186
MySpace Profile: Anna Gardner (annababi10)
Fletcher, OH
(1 - 4 from 5
Anna Gardner's Women's Volleyball Recruiting Profile - NCSA
Evaluate Anna Gardner's women's volleyball recruiting profile. Learn how this South Davidson High School student is connecting with coaches in NC and ...
Copy of Olive Branch Petition by Anna Gardner on Prezi
What Really Happened: What If..... 1. Many Americans at first did not want to permanently break free from England 2. "The Petition expressed ...
Anna Gardner - VT Track and Field Profile
Anna Gardner - VT Track & Field stats and photos on Athletic.net
Anna Gardner's (Grant, MI) High School Volleyball Stats - MaxPreps.com
View Anna Gardner's career, season and match-by-match volleyball stats while attending Grant High School.
Management & Stakeholders
Anna Gardner: Are homeschooled students being held back?
For some people homeschooling holds a negative connotation. A lot of times I have heard people say that homeschooled kids are stupid or they are sheltered and have no
Business Profiles
(1 - 4 from 13
Xing: Anna Gardner
Inhaberin / Wiesbaden, Deutschland
Anna Gardner - ResearchGate
Researcher » Anna Gardner, University of Birmingham, School of Biosciences, United Kingdom, Zoology, Ecology and Animal Communications.
Anna Gardner - Model Mayhem
I am a Dietetics major and fitness junkie and I love embracing my womanhood! I represent the perfect marriage between beauty and health. I am on a mission to ...
Anna Gardner - The Power of Feminine Presence Calgary ...
Hi, Looking forward to the evening and deepening my connection with feminine power. Anna.
Private Homepages
(1 - 4 from 7
Women Who Made History at the Atheneum | Nantucket ...
Forty years later Anna Gardner remembered "the pleasure" of listening to Stone's lectures to a "large and intelligent" Atheneum audience. She noted that ...
annagardner | Just another WordPress.com site
Just another WordPress.com site
ARTSPACE - Staff and Board
Staff and Board Staff Director. Caterina Riva is the director and curator of Artspace. Gallery Administrator. Anna Gardner handles publication and edition sales and ...
Anna Gardner Photography | home
home; about; wedding; portrait; commercial; post-processing; gallery (1) gallery (2) login
Anna Gardner - Tollers Solicitors
e email@example.com t 01536 276732. Job Title: Fixed Fee Case Handler Related Service: Injury Claims Specialties: Personal Injury Office: Corby.
(1 - 4 from 64
classmates: Anna Gardner
Turlock High School, Turlock, CA, 1997-2001
classmates: Anna Gardner
Palo Verde High School, Tucson, AZ, 1990-1994
classmates: Anna Gardner
Keystone Oaks High School, Pittsburgh, PA, 1964-1968
ratemyteachers: Anna Gardner
Cincinnati, OH, Finneytown High School
Celebrities & Politicians
(1 - 2 from 3
Bad news
(1 - 4 from 52
legacy.com: Anna Gardner
Family-Placed Death Notice GARDNER, Anna Anna Gardner, 85, of Fayetteville died Sept. 20, 2010. See full obituary and service times at southcarecremation.com
legacy.com: Anna Gardner
GARDNER Anna Gardner, 86, of Columbus, passed away Friday, August 1, 2008, at Manor Care of Westerville. Member of North Broadway United Methodist Church in Columbus. 50 year
findagrave: Gardner, Anna
01/25/1816 - 02/18/1901, Nantucket (Nantucket County, Massachusetts)
Anna GARDNER - Legacy.com
GARDNER Anna Mae (nee Wiener) of Loveland. Beloved wife of the late Donald Gardner. Loving mother of Rene Dahlheimer, Michael ...
(1 - 4 from 22
- Person Page 8494 - The Peerage
Spencer Perceval and Jane Wilson.1 He married Anna Gardner, daughter of Thomas Gardner, on 31 March 1834.1 He died on 28 February 1876 at age 73.1
Arnold Tifft who married Anna Gardner, renns. Co NY - GenForum ...
Yes, indeed Arnold and Anna (Gardner) had William who married Sally Mitchell. This family moved to Petersburgh around 1797-1800 from ...
Julia Anna Gardner (1882 - 1960) - Genealogy - Geni
Genealogy for Julia Anna Gardner (1882 - 1960) on Geni with over 100 million profiles of ancestors and living relatives. Page updated August ...
Anna Gardner (Rolfe) (1626 - d.) - Genealogy
Genealogy for Anna Gardner (Rolfe) (1626 - d.) on Geni with over 100 million profiles of ancestors and living relatives. Page updated today.
Anna Gardner - JustGiving
Sadly my Dad passed away due to MSA at Christmas last year. I'm really keen to support the MSA Trust given MSA is such a hard disease to ...
Books & Literature
(1 - 4 from 14
The Midway Group of Texas: 1933 - Julia Anna Gardner ...
The Midway Group of Texas: 1933. Front Cover. Julia Anna Gardner, Thomas Wayland Vaughan, Willis Parkison Popenoe. The University, 1935 - Paleontology ...
From Jamestown to Texas: A History of Some Early Pioneers ...
Children: John Gardner, Martin Gardner, Bryan Gardner, James Gardner, Sarah Gardner, and Anna Gardner. Lewis was the only child of William Gardner ...
If Our Lives Be Spared: A Saga of the Collin Family ...
23, 1917 ' Anna Gardner (# 343) b. Dec. II, 1850 d. Sep. 1, 1869 ' Miriam Gardner (# 344) b. Sep. 6, 1852 d. Sep. 17i18, 1931 ' William Gardner (# 3451 b. Mar.
Stand and Prosper: Private Black Colleges and Their Students
from an 1867 exchange of letters between Anna Gardner, a northern teacher in a black school in Virginia, and James C. Southall, editor of the Chronicle, ...
Related Documents
Anna Gardner | University of Birmingham - Academia.edu
Anna Gardner · University of Birmingham, School of Biosciences, Undergraduate edit. Message. Unfollow Follow Unblock. Research Interests: Journal of ...
AAPG Datapages/Archives: Memorial: Julia Anna Gardner (1882-1960)
Julia Anna Gardner died on November 15,. 1960, at her home in Bethesda, Maryland, at the age of 78. She left as her heritage contributions. Continued on next ...
Anna Gardner | La Trobe University - Academia.edu
Anna Gardner's webpage on Academia.edu ... Reset Password. Enter the email address you signed up with, and we'll send a reset password email to that address
Anna Gardner memorial - Internet Archive
My life after Tinnitus | Mike de Velta
19.02.2009 Anna Gardner April 16th, 2010 @ 7:41 pm. I have been suffering from pulsatile tinnitus for over 20 yrs now. The ringing, hissing, rushing sounds all at once 24/7 for over 20 yrs. I have found no escape and people don't really understand ...
Introducing: The Mills Church
02.06.2009 When Anna Gardner oversaw the writing of our history book, which recounts our first hundred years, the unifying name chosen for these first two eras was "The Mills Church". I really like that name, the Mills Church. ...
Anna Gardner's (annag_25) Library | Photobucket
Photo Album by annag_25. . 49 photos and 2 videos.
Video & Audio
Festive Bold Lip with Anna Gardner - YouTube
► 2:19► 2:19Watch Anna apply the Bronze Goddess Bronzer after her base to softly define her cheeks, keeping her eyes ...
Anna Gardner - Channel Producer reel - YouTube
Channel Producer reel with short form programming. All contents (c) ESPN Classic.
Anna Gardner - Producer reel (Long form) - YouTube
Showreel from work as a Producer/Director at ESPN Classic. Now developing factual and documentary TV content in Los Angeles and London. All content is (c
(1 - 4 from 15
OLPH Student Create Smiles with Bake Sale
06.04.2012 [Patch.com] - "I think it's amazing how many children we are able to help and how many people stepped forward to help us raise money," said Anna Gardner, one of the students who participated in the bake sale. "I think it was important for us to do this so that we
Julia Anna Gardner - The Times of India - Indiatimes
See Julia Anna Gardner Latest News, Photos, Biography, Videos and Wallpapers . Julia Anna Gardner profile on Times of India.
Meet the vloggers: Self employed and 'worth a fortune ... - BBC
Anna Gardner, 24, who runs the Vivianna Does Make Up blog says it's not money for nothing. "I wake up at six," she says. "I'm on my laptop ...
Boone County: Gardner donation honors daughter - INHF ...
At age nine, Anna Gardner sent a fan letter to Euell Gibbons, author of many popular books about gathering and eating wild plants. She was already applying ...
Reports & Statements
(1 - 4 from 92
Twitter Posts: Anna Gardner (anna_gardner)
17.07.2012 #TweetAPictureYouCantExplain @asheconnor http://t.co/M35B5cTz
anna gardner on Tumblr
Find and follow posts tagged anna gardner on Tumblr.
bloglovin.com: Anna Gardner on Bloglovin
Posts liked by Anna Gardner on Bloglovin. ... Anna Gardner. FollowFollowing · FollowFollowing. Don't miss any updates from. Anna Gardner ...
2 Days Until Departure! - Anna Gardner - Global Leadership ...
Anna Gardner. Hey, everyone! My name is Anna and I am a Marketing major hailing from the land of the delta blues: Memphis, TN. I have lived ...
(1 - 20 from 79
Anna Gardner - Yahoo UK & Ireland Lifestyle
View the picture 'Anna Gardner' from the photo gallery 'Best Beauty YouTubers And Vloggers 2014' on Yahoo Lifestyle UK. Anna Gardner The ...
Anna Gardner - Delight | Landeshauptstadt Wiesbaden
Anna Gardner - Delight: Unternehmen: Delight Gründerin: Anna Gardner Gründungsdatum: 1. März 2012 Branche und Unternehmen: Delight verkauft Vintage-, ...
Anna Gardner - Get The Gloss
With beauty aspirations from as early as nine years old, Anna Gardner's love affair with make-up began with a blue eyeshadow from Claire's Accessories – and ...
Anna Gardner | Jeanie Davison
Posts about Anna Gardner written by Jeanie Davison.
Anna Gardner — University of Leicester
Anna Gardner. ... Anna Gardner. Anna Gardner. Anna Gardner Full-size image: 1.3 MB | View image View Download image Download. Share this page:.
Anna Gardner: Founder & Editor, Vivianna Does Makeup
Magazine Anna Gardner .... Ever the early-adopter, Anna Gardner took her first steps into beauty at the age of nine, when she managed to score a blue ...
Anna Mae Gardner Obituary, Loveland, OH | Tufts ...
... Juanita (Bob) Hendryx, Donald (Phyllis) Gardner Jr., Andy (Robyn) Gardner, and Anna Gardner. Cherished grandmother of 36 grandchildren ...
Anna Gardner Obituary - Westcott Funeral Home
... in Cottonwood, located on Hombre Drive. Read Anna Gardner's Obituary and Guestbook on www.westcottfuneralhome.com. back to top ...
Pet Synergy - Holistic Veterinary Medicine
Dr. Anna Maria Gardner M.A. Vet.MB MRCVS - Holistic Veterinarian - Serving Washing State & the World
Anna Gardner's House - Museum of African American History
Black Heritage Trail, Nantucket: Anna Gardner's House.
Campbell University Robert B. and Anna Gardner Butler ...
Dedicated on Oct. 4, 2009, the Anna Gardner and Robert B. Butler Chapel is located on the Academic Circle adjacent to the Taylor Hall of Religion. The 10,000 ...
Esther Anna Gardner - Kader-Neff Funeral Home
Esther Anna Gardner, 91 of Jersey Shore formerly of Eagleville, passed away Saturday, November 21, 2009 at the Manor Care Nursing Home in Jersey Shore.
Anna Gardner - Doula Profile | Doula UK
Originally from the North West of England, I have lived in and around London since 2000, when I first met my husband. We now live in South London with our ...
Anna Gardner | NCT
Would you like Anna to be your Doula? Email email@example.com or call 07956064516. About Anna. Anna lives in South Croydon with her husband and ...
Blogger Crush: Anna Gardner of Vivianna Does Makeup ...
Why We Love Her: When it comes to beauty blogs, the Brits have some of the best sites going and Gardner is one of our daily must-reads.
GARDNER, JULIA ANNA - Texas State Historical Association
Julia Anna Gardner, geologist, was born on January 26, 1882, in Chamberlain, South Dakota, the only child of Charles Henry and Julia (Brackett) Gardner.
• mine like crazy anton yelchin Felicity Jones jacob helm ...
mine like crazy anton yelchin Felicity Jones jacob helm anna gardner.
Archer Bushby | Lawyers : Our Team
Anna Gardner graduated from the University of Tasmania with a Bachelor of Economics/Bachelor of Laws in 2002. In 2003 she completed a Graduate Certificate ...
Art 08-13 » Nob Hill Gazette
In the 1970s, Anna Gardner had a second home in Stinson Beach and opened a gallery on the main street of town. The Anna Gardner Gallery showed works by ...
Former Derby head teacher's daughter to take on 300km ...
Anna Gardner will run, cycle and swim a total of 300km to raise money for the MSA Trust. Her father, Paul Gardner, died after suffering from ...
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text:
iTunes 10.4 is available and ready for Lion
iTunes 10.4 is now available via Software Update, bringing with it full-screen app capability. Plus, iTunes on the Mac is now a 64-bit Cocoa app in Lion. If you're using some older iTunes plug-ins you may have issues with those (according to Apple). Makes sense, as Lion has shed many vestiges of OS X versions past.
We'll update this post with direct links when available.
Source: http://www.apple.com/itunes/
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text:
The Pensions Regulator (TPR) has shut down a group of five pension liberation schemes that had taken more than £134m from over 1,400 people.
21 Nov 2014 | 13:47
Research carried out by PP has found that defined contribution (DC) trustees think communicating the Budget flexibilities to members is their biggest challenge next year.
21 Nov 2014 | 14:08
The biggest stories on PP this week involved controversy over the LGPS, an overhaul at Santander's scheme, a new chief exec at TPR, and a PPF sell off. Here are the top five.
21 Nov 2014 | 07:52
Editor's Picks
PP looks at the potential of online profiling tools to help make retirement decisions
PP speaks to director of pensions Antony Barker about the £8bn fund
PP looks at why trustees are coming under pressure over trapped surpluses and what they can do about it
Con Keating says government attempts to promote shareholder engagement are pointless and will increase costs
In depth
Pensions Buzz
Defined benefit trustees believe managing investment risk will present them with the biggest challenge next year, according to PP research.
Case studies and backgrounds
David Adkins talks about the fund that won the DB Innovation prize at the Pension Scheme of the Year awards
Phillip Bretnall talks to PP about the bank's Know You programme
Natasha Browne looks at the thorough approach Thomas Cook takes to managing risk in its defined contribution arrangements
Finding investment solutions for the pensions crisis
How partnerships are helping employers deal with auto-enrolment
How to reduce risk in volatile markets
Latest by categories
Updating your subscription status
The entry process for the UK Pensions Awards 2015 - which will take place at London's Grosvenor House Hotel on 7 May next year - is now open. Find out how to enter here.
The best of our readers' ideas on how to structure defined ambition pensions
This guide to Pensions Stability explores the new financial and operational model for defined benefit (DB) pension schemes. Pension schemes are still being run with far greater risk than is necessary and there is an opportunity to create a more stable pensions environment for trustees and sponsors.
This inaugural survey among 326 members of the Chartered Institute of Personnel and Development (CIPD) and the Pensions Management Institute (PMI) asked whether auto-enrolment will deliver on its goals; if contribution rates for employees and employers need to rise; and whether pensions tax relief needs further reform.
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text:
I have a struct that has an array of strings (char **args). I need to be able to copy an array of strings (char *input[32]) into that element of the struct. For example:
Thing s;
s.args = input; //assuming input already has some strings in it
When I try to do that, the next time s.args = input is called, it completely overwrites the old input. How can I achieve this functionality in the appropriate manner?
This is what the struct looks like.
typedef struct{
char **args;
} Thing;
Then in my function, I have declared:
char *args[512];
args[count] = string //string is a char *
Then finally, I want to do:
s.args = input.


text:
Tupac: Resurrection (2003)
This posthumous documentary tells the story of Tupac's life and music through rare archival footage, interviews with his family and friends like Jada Pinkett Smith, Treach and his mother, Afeni Shakur. And although his music frequently spoke of his demise, Tupac's narration of his life as the voiceover in the film is completely surreal.
Celebrity Birthdays: Tina Turner Celebrates!11/26/2014
Out and About: Kim Kardashian Swarmed By Paparazzi at LAX11/26/2014
Tweet Sheet: Celebs React to Ferguson Decision11/25/2014
Giving Thanks: What Celebs Are Grateful For11/23/2014
Out and About: Beyoncé Enjoys a Slurpee in NYC11/21/2014
Celebrity Quotes: Wendy Williams Defends Aaliyah Biopic11/21/2014
Break the Internet: Social Media Frenzies11/20/2014
Black Twitter Reacts to #HomeRunNelly11/19/2014
Celebrity Birthdays: Tyga Celebrates!11/19/2014
Celebrities Giving Side-Eye11/18/2014
Celebs Who Didn't Slow Down for Pregnancy11/16/2014
Celebrity Quotes: Aretha Franklin 'Passes' on Nicki Minaj11/14/2014
Out and About: Beyond the Lights Cast Rocks the Red Carpet11/14/2014
Chapter 11: Celebs Who Went Broke11/13/2014
Black Twitter Reacts to Kim Kardashian's Paper Cover11/12/2014
Black Twitter Reacts to Regina Hall and Sanaa Lathan11/12/2014
Celebrity Birthdays: Omarion Celebrates!11/12/2014
Where Are They Now: The Cast of Monster's Ball11/11/2014
Reality Stars Behind Bars11/09/2014
Out and About: KimYe Head Home After a Night in NYC11/07/2014
Celeb Quotes: Chris Brown Blasts Tamar and Adrienne11/07/2014
You Gotta Have It: Things to See, Hear and Cop This Month11/06/2014
#RHOH: Black Twitter Reacts to Mike Epps Throwing Shots11/05/2014
Nip and Tuck: Celebrity Plastic Surgery11/04/2014
Celebrity Birthdays: Diddy Celebrates!11/04/2014
November Movie Preview11/03/2014
Out and About: Alicia and Swizz Arrive to the Black Ball10/31/2014
Celebrity Quotes: Wendy Williams Blasts Tiny's Eye Implants10/31/2014
I'm a Survivor: Black Actors Who Didn't Die in Horror Films10/30/2014
RHOH: Black Twitter Reacts to Kevin Hart and Lance Bass10/29/2014
Celebrity Birthdays: Gabrielle Union Celebrates!10/29/2014
Fade to Black: Best Black Horror Films10/28/2014
The Stars of Beyond the Lights10/27/2014
Ten Things You Need to Know About Beyond the Lights10/27/2014
Celebs Who Could Survive a Zombie Apocalypse10/27/2014
Celebrity Quotes: T.I. Refuses to Apologize to Azealia Banks10/24/2014


text:
Rugby Union
Select a team
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Conor Murray
Conor Murray has signed a new two-year Munster deal
Tuesday 10th December 12:40
Ireland scrum-half Conor Murray will be staying with Munster until at least June 2016, after signing a new two-year contract with the Irish Rugby Football Union.
Pro12: Munster scrum-half Conor Murray avoids suspension
Wednesday 30th October 15:58
Conor Murray is free to play for Ireland in next month's autumn internationals after escaping further punishment for an incident during Munster's win over Glasgow last weekend.
PRO12: Munster and Ireland scrum-half Conor Murray cited
Monday 28th October 09:46
Conor Murray could miss Ireland's autumn internationals after he was cited for an alleged incident during Munster's win over Glasgow Warriors on Friday.
British and Irish Lions tour: Cian Healy cited for 'alleged bite'
Wednesday 5th June 17:55
British and Irish Lions prop Cian Healy has been cited for an alleged bite during the 69-17 victory over Western Force.
British and Irish Lions: Paul O'Connell leads by example, claims Conor Murray
Thursday 30th May 06:27
British and Irish Lions scrum-half Conor Murray has hailed the selection of Paul O'Connell as captain for the opening tour match against the Barbarians on Saturday.
Six Nations: Conor Murray confident in defensive ability of Ireland's wings
Wednesday 30th January 16:30
Conor Murray has warned Alex Cuthbert and George North that Ireland's less imposing wings will withstand the Welsh assault.
Brian O'Driscoll back in Ireland side for Six Nations opener against Wales
Tuesday 29th January 13:56
Brian O'Driscoll, Rob Kearney, Sean O'Brien and Rory Best are restored to the Ireland starting line-up for Saturday's Six Nations trip to Wales.
BO'D - Eddie will be fired up
Saturday 10th September 15:19
Brian O'Driscoll has no doubt that USA coach Eddie O�Sullivan will be desperate to topple Ireland on Sunday.
Murray surprised by call
Monday 22nd August 20:51
Conor Murray is still struggling to come to terms with his shock inclusion in Ireland's World Cup squad.
Murray given Ireland chance
Monday 22nd August 13:30
Conor Murray has been named in Ireland's 30-man World Cup squad at the expense of fellow scrum-half Tomas O'Leary.
Phil Edwards explains why England's World Cup dreams will not be over if they lose their next two games
If England are to have any chance of launching a successful assault on the Everest that is next year's World Cup, then the widespread feeling seems to be that they simply have to win their next two games.
Pro12 Highlights
Highlights of all the Pro12 action, including Ulster's win over the Ospreys and Treviso's draw with Leinster.
Back Ireland to continue their winning ways
It has been fairly even between Ireland and Australia in the last six meetings, three wins to Australia, two Irish victories and a draw, but recent form comes down in Ireland's favour, with eight wins from nine contrasting to Australia's three victories in nine.
Experts & Blogs
Phil Edwards
Read the thoughts and opinions of Phil Edwards with skysports.com