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Printed from the IBC Life Sciences Web site on November 28, 2014 8:10 PM ET.
Page location: http://www.ibclifesciences.com/ProteinSummit/agenda.xml
June 04-06, 2014
Grand Hyatt Hotel
San Francisco, CA
Track A
Chairman's Opening Remarks
Robert Mabry, Ph.D., Director of Protein Sciences and Antibody Technology, Jounce Therapeutics
Creative Protein Engineering and Design Approaches
Unpublished DataCase StudyDeep Sequencing Guided Engineering of Affinity and Stability of a Dual Action Fab to Obtain In Vivo Efficacy
We set out to generate a dual action Fab(DAF) against two soluble antigens with high dual affinity. To improve the DAF we used an approach, which combines affinity based selection on phage with deep sequencing. Through this approach we generated several variants of DAF, which possess sub-nanomolar affinity for both antigens as well as higher thermo stability. The improved variants now showed improved efficacy in an animal gating model. Further, mapping the optimized variants with structural data of the DAF in complex with both antigens allows us to deduce improved strategies for maturation library design in the future.
Patrick Koenig, Ph.D., Postdoctoral Research Fellow, Antibody Engineering, Genentech, Inc.
Unpublished DataEfficient Design and Engineering of Bi- and Tri-Specific DART Proteins
A challenge in developing robust and stable complex biologics such as bispecifics and ADCs is ensuring that the component elements assemble correctly in a homogeneous manner and that undesired side-products are minimized in the final product. This presentation will focus on design and engineering elements that are incorporated into production of bi- and tri-specific DART proteins, focusing on longer half-life versions.
Syd Johnson, Ph.D., Vice President, Antibody Engineering, MacroGenics, Inc.
Unpublished DataRapid High-Resolution Functional Epitope Mapping of Antibodies Using Yeast Surface Display and Deep Sequencing
Here we demonstrate the functional epitope mapping of a panel of Staphylococcus aureus alpha toxin neutralizing antibodies with a level of speed and precision never seen before by using a rationally designed library, yeast surface display and high throughput DNA sequencing. This approach also produces quantitative insights into the antibody-antigen interaction which was exploited to select antibodies for oligoclonal therapy.
Thomas Van Blarcom, Ph.D., Principal Scientist, Protein Engineering, Pfizer Inc.
Networking Refreshment Break in Poster & Exhibit Hall
Unpublished DataDesign Principles for Bispecific IgGs - The H-L Pairing Challenge
Bispecific IgGs are preferably of the IgG format. One of the key challenges in making bispecific IgGs is correct H-L chain pairing. We present a solution, disulfide stabilization, where an engineered disulfide bond H and L chains replaces the natural disulfide bond between the CH1 and CL domains. We efficiently produce several such bsAbs in bacteria and in mammalian cells.
Itai Benhar, Ph.D., Professor, Molecular Microbiology and Biotechnology, Tel-Aviv University, Israel
Unpublished DataEngineering of Strong Erbb2-Binders with Adaptable Albumin-Binding
I will describe in detail how we have generated high affinity binders to ErbB2 and how we achieve a unique flexibility to switch between a monospecific target-binding molecule and a bispecific form that also binds albumin. This allows convenient adaptation to a format suitable for molecular imaging or therapy. The first and very promising in vivo data of an ErbB2-binding variant with sub-nanomolar affinity were recently acquired. I will here for the first time present initial data on tumor imaging using this scaffold.
Johan Nilvebrant, Ph.D., Post Doctoral researcher, Protein Technology, Royal Institute of Technology - Biotechnology, Sweden
Unpublished DataNovel Asymmetrically Engineered Antibodies with Unique Functions
Two examples for asymmetric antibody engineering enabling unique functions that cannot be achieved by conventional antibody will be presented. One is asymmetric Fab engineering to design bispecific antibody against FIX and FX mimicking FVIII function, which is being investigated in Phase 2. Second is asymmetric Fc engineering to fine-tune the asymmetric Fc-FcgR interaction for maximizing FcgR binding affinity and ADCC.
Futa Mimoto, Researcher, Research Division, Chugai Pharmaceutical Co., Ltd, Japan
Unpublished DataApplication of In Vitro V(D)J Recombination to Generate Peptide-Grafted Antibodies to G Protein-Coupled Receptors
A novel strategy to place sequences encoding GPCR-targeting peptides into the CDRs of full length human antibodies is presented. Utilizing RAG-mediated V(D)J recombination for the generation of large de novo libraries of peptide-grafted antibodies allows for the simultaneous diversification of the length and amino acid composition of flanking antibody-peptide junctions. Peptide-grafted antibodies have the potential to extend the in vivo half-life of peptides and to protect them from proteolytic processing improving their utility as therapeutics.
Michael Gallo, Ph.D., President, Discovery, Innovative Targeting Solutions, Inc.
Track B
Chairman's Opening Remarks
Dragan Grabulovski, Ph.D., Chief Scientific Officer, Covagen AG, Switzerland
Constraining Peptides for More Drug Like Properties
Unpublished DataCase StudyDevelopment of Bicyclic Peptides for Therapeutic Application
Bicyclic peptides combine key qualities of antibody therapeutics (high affinity and specificity) and advantages of small molecule drugs (access to chemical synthesis, diffusion into tissue, various administration options). We have developed bicyclic peptide antagonists or ligands with nanomolar or even picomolar binding affinity to a range of important disease targets. First studies in mice show that they are stable and active in vivo.
Christian Heinis, Ph.D., Assistant Professor, Institute of Chemical Sciences and Engineering, Ecole Politechnique Fédérale de Lausanne (EPFL), Switzerland
Unpublished DataRibosomal Synthesis and Discovery of Constrained Peptides and Pseudo-Natural Products
We have developed RaPID system that enables for the ribosomal synthesis and discovery of constrained macrocyclic peptides from over a trillion of members of such peptides. We also recently devised the next generation system consisting of RaPID system and post-translational modifying enzymes. I shall provide a sneak preview of this technology.
Hiroaki Suga, Ph.D., Professor, The University of Tokyo, Japan
Development of Immunotherapies
New DataCharacterizing BiTE® Human/Cyno Target Affinity Gap Using the Octet RED384 Biosensor
Cancer immunotherapy is the process by which the immune system is used to treat cancer. One application in this field is Bispecific T-cell Engaging proteins (BiTE® molecules). BiTE® molecules bind CD3 receptors on T-cells as well as to a tumor-specific antigen. By bringing the T-cells into such close proximity of tumor cells, the T-cells are able to activate and kill cancer cells. At Amgen, BiTE® molecules are being developed that bind different tumor antigens for several different cancer indications. One key characteristic is that each BiTE® tumor binding domain must be able to crossreact to both the human and cynomolgus macaque (cyno) tumor targets. Cyno crossreactivity is required to perform the preliminary cyno toxicity studies to assess on-target toxicity for each BiTE® cancer indication. We developed a set of methods using an Octet RED384 biosensor to characterize the binding kinetics and affinity of different BiTE® panels for the human and cyno tumor targets. By using minimally-biotinylated soluble receptors loaded onto streptavidin biosensor tips, we ensured that identical target load levels were used for the human and cyno binding experiments and we were therefore able to directly compare the two measured affinities and calculate a human/cyno affinity gap. Additionally, we observed whether the binding kinetics were consistent with a 1:1 binding model in order to identify well-behaved BiTE® molecules or to flag those with complex binding. Our binding results rank order typically correlated well with other in vitro and cell binding experiments based on the same tumor targets. The affinity results for each BiTE® panel were considered together with the manufacturability assessments and in vitro T-cell Dependent Cellular Cytotoxicity (TDCC) killing activity to identify the top candidates for further in vivo studies.
Ryan Case, Ph.D., Principal Scientist, Biologics Discovery, Amgen, Inc.
Networking Refreshment Break in Poster & Exhibit Hall
Bi- and Tri-Functional Antibody-Cytokine Fusion Proteins for Cancer Immunotherapy
Cytokines with immunostimulatory/costimulatory properties have shown great potential to support the generation and development of an antitumor immune response. In order to improve the efficacy of such molecules at the tumor site we designed bi- and tri-functional antibody-cytokine fusion proteins, focusing on targeted presentation and a combined mode of action, demonstrating enhanced immune responsiveness in vitro and antitumor activity in vivo.
Dafne Müller, Ph.D., Group Leader, Institute of Cell Biology and Immunology, University of Stuttgart, Germany
Blinatumomab - History, Mechanism Clinical Update, and Future Path of BiTe Technology
Abstract not available at time of print.
Tap Maniar, MD, Medical Director, Oncology, Amgen Inc.
Unpublished DataEngineering Human MICA as a Novel Immunotherapeutic Scaffold
Natural Killer (NK) cells employ the NKG2D receptor to seek and destroy cancerous or virally infected cells displaying the NKG2D activating ligand, MHC-I related chain A (MICA). New data will be presented describing the development of MICA into an immunotherapeutic scaffold by engineering both target antigen binding and NK effector recruitment properties. These agents, termed Micacides, offer an NK cell-directed approach for treating cancer and viral diseases.
Kyle Landgraf, Ph.D., Senior Scientist, Immunotherapeutics, AvidBiotics Corp.
Case StudyTools and Technologies for Immunogenicity Risk Management
Emilee Knowlton, Ph.D., Immunology Sales Specialist, ProImmune, Inc.
Networking Luncheon in Exhibit and Poster Hall with "Hot Topic" Roundtable Discussions
Moderated by Conference Speakers - Join us during this afternoon's luncheon for informal, moderated hot topic discussions led by your conference speakers. Discuss and debate important industry issues and challenges with other attendees and speakers and make new contacts at the same time.
Moderator: Dragan Grabulovski, Ph.D., Chief Scientific Officer, Covagen AG, Switzerland
Moderator: Jonathan Davis, Ph.D., Principal Scientist, Protein Design, Bristol-Myers Squibb
Moderator: Fredrik Frejd, Ph.D., Chief Scientific Officer, Affibody AB, Sweden
Chairman's Remarks
Arne Skerra, Ph.D., Managing Director & Chief Scientific Officer, XL-protein GmbH, Germany
Next Generation ADCs - Novel Conjugation Technologies, Linkers and Payloads
Unpublished DataCase StudyAdvances in Drug Conjugate Technology Using Centyrin Proteins
Centyrex has designed a novel FN3 domain alternative scaffold with superior stability properties and is exploring the robustness of the platform via novel therapeutic applications that may address outstanding challenges in antibody drug conjugate technology. We will describe how the excellent biophysical properties of Centyrins make them ideal conjugation partners for applications designed to combine small molecule and large molecule opportunities.
Robert J. Hayes, Ph.D., Venture Leader and Vice-President, Janssen R&D, a Johnson & Johnson company
Case StudyNovel Pyrrolobenzodiazepine Payloads for ADC Therapies
The pyrrolobenzodiazepines (PBDs) are a family of naturally occurring antitumour antibiotics found in various Streptomyces species. Completely synthetic, highly potent PBD dimers have been developed as antitumour agents and these molecules have been modified to allow conjugation to tumour targeting antibodies. The resulting PBD antibody conjugates have exhibited excellent in vivo antitumour activity across a range of xenograft models.
Philip Howard, Ph.D., Chief Scientific Officer, MedImmune Spirogen Business Unit, United Kingdom
Unpublished DataAntibody Drug Conjugates with Novel DNA Alkylating Agents: Design and Preclinical Evaluation
The cytotoxic effector molecule is a key component of antibody-drug conjugates (ADCs). A new class of potent DNA-alkylating agents, (IGNs), have been designed and synthesized for use in ADCs. These compounds are cytotoxic in vitro towards cancer cell lines, with IC50 values in the picomolar range. Results from preclinical evaluation of ADCs of these novel DNA alkylators will be presented.
Ravi J. Chari, Ph.D., Executive Director, Chemistry and Biochemistry, ImmunoGen, Inc.
Networking Refreshment Break in Poster & Exhibit Hall
Unpublished DataDeBouganin: De-Immunized Cytotoxic Payload for Targeted Cancer Therapy
Immunotoxin fusion proteins represent a highly potent alternative to conventional anti-cancer agents. We have developed a de-immunized variant of the plant-derived, type I ribosome-inactivating protein (RIP), bouganin. Various antibody drug formats linked to deBouganin were engineered and characterized for biologic activity. The biologic characterization of deBouganin-conjugates as well as the Phase I clinical data are presented.
Glen C. MacDonald, Ph.D., Chief Scientific Officer, Viventia Bio Inc.
Towards Homogeneous ADCs - The Promise of Better Clinical Impact and Product Safety
Addressing Tumor Heterogeneity and Resistance; Production of Homogeneous ADCs with Combination Warheads
Homogeneous single species ADCs hold the promise to enhance the efficiency of tumor killing while reducing systemic damage and increasing their tolerability. Making many positional variants to assess the best candidate positions for conjugation is challenging using conventional cell based expression systems. Using biochemical protein synthesis methods, parallel production of many positional variants can be expressed in hours and rapidly assessed for function. We will describe the power and utility of the platform to address efficient non-natural amino acid incorporation and optimized conjugation kinetics for manufacturing. Finally we will demonstrate the design and manufacture of new classes of homogeneous mono- or multi-specific antigen-targeted antibodies conjugated to combinations of different warheads promising even better clinical impact and safety.
Trevor Hallum, Ph.D., Chief Scientific Officer, Sutro Biopharma, Inc.
Unpublished DataCase StudySite Specific Bioconjugates - A Pathway to Better Biologics
Biological therapeutics are effective interventions in many diseases. However it is apparent that the natural protein is often not optimum due to shortcomings such as in potency PK, delivery or specificity. To address this, modifications or conjugations to the proteins/peptides have been made, for example to extend half-life, to incorporate cytotoxic moieties or to impart additional pharmacology. To do this well requires an exquisite understanding of the effect of the site of conjugation on the function, stability, pharmacology and toxicology of the resulting bioconjugate. The specific incorporation of a non-natural amino acid subsequently allows a detailed determination of how to build the optimal bioconjugate. We will discuss Ambrx's approach.
Alan Wahl, Ph.D., Vice President, Discovery and Research, Ambrx Inc.
Close of Day Two
Happy Hour @ Pier 39 Overlooking San Francisco Bay
This networking reception is at Players Sports Grill & Arcade, which has sweeping views of San Francisco Bay. Enjoy buffet finger food and drinks (beer, wine, soft drinks) plus arcade games and pool tables. Advance RSVP is required when registering with an additional $125 fee. Stop by the registration to reserve your spot by Wednesday at 5pm.
Track A
Chairman's Opening Remarks
Manuel Baca, Ph.D., Fellow, Antibody Discovery and Protein Engineering, MedImmune LLC
Library Design, Screening, Selection, and Display Technologies and Platforms
Unpublished DataEffect of Library Design on Adnectin Properties
Adnectins against targets of therapeutic interest are selected from complex libraries based on the tenth human fibronectin type III domain. Libraries with higher sequence and structural diversity are expected to yield domains with higher affinity and poorer stability. We tested this assumption by evaluating 1,200 Adnectins from different libraries, and found critical elements of library design additional to overall diversity.
Daša Lipovšek, Senior Principal Scientist, Molecular Discovery Technologies, Bristol-Myers Squibb
Unpublished DataMammalian Cell Display Allows Co-Selection of Human Antibodies for Functionality and Developability
Mammalian cell display together with simultaneous secretion of IgG, allows antibodies to be selected for both functionality and excellent biophysical properties for development. Coupled with in vitro somatic hypermutation, this enables highly potent antibodies to be generated. The use of high-throughput sequencing during this process allows insight into maturation pathways, and can be used to rapidly identify optimized antibodies.
David J. King, Ph.D., Chief Scientific Officer, AnaptysBio
Unpublished DataCase StudyMicro-scale Developability Assessment in Discovery: Case Study with a ScFv Based Fifunctional
The presentation will outline a robust process we have established in the Discovery Research space to design, triage, and optimize biotherapeutic leads with optimal physicochemical properties before they reach the lengthy and costly Development phase.
Laura Lin, Ph.D., Director, Biophysics, Analytics, & Bioconjugation, Global Biotherapeutic Technologies, Pfizer Biotherapeutics Research
Networking Refreshment Break
Case StudySelective Regulation of the Insulin Receptor by Human Allosteric Monoclonal Antibodies
Abstract not available at time of print.
Hassan Issafras, Ph.D., XOMA Corp.
Unpublished DataCase StudyThe Better Biologic: Library Design Principles Inspired from Repertoire Systems Immunology
Synthetic antibody library technologies allow the creation and parallel selection of billions of engineered biologics. As even the largest libraries occupy only an infinitesimal subset of all theoretical sequence space, the choice of antibodies occupying a library can have a tremendous impact on the fitness of the library as a whole. High throughput sequencing of both natural repertoires and library selections have provided a powerful new method to directly observe the sequence activity landscape of antibody populations. In this presentation, I review some of the most relevant repertoire observations, and illustrate how they can be applied towards the design of a maximum diversity single domain library, and a pre-encoded general human affinity maturation landscape.
Jacob Glanville, Scientific Director, Distributed Bio
Unpublished DataCase StudyUsing Stabilised Receptors as Antigens to Generate Therapeutic Antibodies to GPCR Targets
Stabilized receptors offer a breakthrough solution to the central challenge of reliably making pharmacologically active antibodies against GPCRs. They enable the production of purified, properly folded and functional protein when removed from the cell membrane for use as an antigen. This case study provides important validation of this solution and further demonstrates that StaR antigens preserve biologically relevant epitopes, thereby enabling generation of diverse panels of functional antibodies.
Catherine Hutchings, Ph.D., Principal Scientist, Antibody Discovery & Strategic Partnering, Heptares Therapeutics Ltd, United Kingdom
Unpublished DataReD - Ultrarapid Antibody Discovery Via Combined Cellular and Lambdoid Polyvalent Display
Retained Display (ReD), is a novel cytoplasmic display platform enabling rapid and seamless switching between cellular and lambdoid phage display. We report novel human germline antibody scaffolds that are fully soluble in the cytoplasm discovered using ReD and their use in a library built on the ReD platform.
Ben Kiefel, Ph.D., CEO and Co-Founder, Affinity BIO, Australia
Lunch on Your Own
Chairman's Remarks
Ted Randolph, Ph.D., Professor, Department of Chemical and Biological Engineering, University of Colorado, Boulder
Confront Aggregation Concerns in Early-Stage Development
Featured Presentation
Unpublished DataCase StudyStrategic Approaches for Understanding and Hindering Aggregation
Learn about a new strategic approach for developability based on applying both molecular and macroscopic modeling tools in order to gain an understanding of degradation processes with unprecedented detail and accuracy. Take an aggregation-themed focus on the Spatial-Aggregation Propensity and Developability Index algorithms, which can be applied from the discovery phase through the development phase to identify problems early on and address them. Also, similar tools for viscosity and crystallizability will be described. Note: The speaker will present remotely from Boston.
Bernhardt L. Trout, Director, Novartis-MIT Center for Continuous Manufacturing; Co-Chair, Singapore-MIT Alliance; Chemical and Pharmaceutical Manufacturing Professor, Department of Chemical Engineering, MIT
Case StudyEngineering Strategies to Cure Cellular Aggregation of a Difficult-to-Express Fusion Protein
Based on kinetic modeling of the cellular synthetic process, we compared different strategies (cell engineering, modulation of culture environment) to alleviate cellular aggregation and the associated poor expression of a recombinant Fc-fusion protein by CHO cells. Our analysis serves as a paradigm for multivariate optimization of DTE protein production.
David C. James, Ph.D., Department of Chemical and Biological Engineering, University of Sheffield, United Kingdom
Unpublished DataCase StudyHigh Throughput Developability Screening Methods Targeting Antibody Self/Cross Interaction
Developability issues, such as aggregation, low solubility, high viscosity and poor pK can be tracked to antibody self or cross interaction. High throughput methods are currently available to screen hundreds to thousands of antibodies within a single day to be compatible with early stage antibody discovery. A quick overview of a few high throughput self and cross interaction screening assays and their correlation. Depending on the progress of currently on-going mouse pK experiment, correlation of serum clearance with each individual assay will be discussed.
Yingda Xu, Ph.D., Group Leader, Protein Analytics, Adimab
Networking Refreshment Break
Unpublished DataAggregation in Biopharmaceuticals in Human Plasma and Serum: From In Vitro Analysis to In Vivo Implications
Aggregation phenomena can occur in vivo after the injection or infusion of a clear, non-aggregated protein solution. The aggregates formed at the injection site in tissue or in the bloodstream may have toxic and immunogenic effects. This talk presents new data on the characterization of the aggregates formed in vitro when different formulations of therapeutic proteins are mixed with human plasma and blood. Explore a model for the aggregation, and discuss clinical implications of the aggregation induced by biopharmaceuticals.
Tudor Arvinte, Ph.D., Professor, School of Pharmacy Geneva-Lausanne, University of Geneva, Switzerland and CEO, Therapeomic, Inc.
Approaches to Improve Prediction and Mitigate Risk of Immunogenicity
Unpublished DataCase StudyClinical Relevance of Immunogenicity
This presentation will provide case study examples of how pre-clinical methods measuring drug induced T cell responses can be applied to select drugs with a reduced risk of clinical immunogenicity. Furthermore, new data will be presented on how aggregates in some formulations can trigger innate responses that ultimately enhance immunogenicity. The clinical relevance to these findings will be discussed.
Gary Bembridge, Ph.D., Director, Scientific Affairs - Immunology, Antitope Limited, United Kingdom
Unpublished DataUnderstanding the Immunogenicity Risk to Aggregated Particles in a Biotherapeutic
Protein aggregates in biotherapeutics, such fully human antibodies (mAbs), can be potentially immunogenic. You can encounter aggregated particles in formulations during the manufacturing, storage, and delivery process. The aggregate attributes that can play a role include protein sequence, particle size, and particle number. The immune status of the individual also modulates the response to such risk factors. During this talk, evaluate the threshold of immune response to the number and size of particles associated with aggregates and the relevance of the readout of in silico, in vitro, and in vivo assays in the context of a real-time formulation.
Vibha Jawa, Ph.D., Principal Scientist, Clinical Immunology, Amgen Inc.
Close of Conference
Track B
Chairman's Opening Remarks
Peter A. Kiener, Ph.D., Chief Scientific Officer, Ambrx
Alternatives to PEG for Plasma Half-Life Extension
Unpublished DataPASylation - The Biological Alternative to PEGylation
Short plasma half-life is a major draw-back of most biopharmaceuticals. PEGylation of biological drugs is now widely applied, but has disadvantages with regard to high production cost and accumulation in various tissues. PASylation allows the simple genetic fusion (or chemical coupling) of a therapeutic protein or peptide with a voluminous hydrophilic and biodegradable polypeptide composed of Pro, Ala, and/or Ser to retard kidney filtration, thus allowing the design of better drugs with prolonged action.
Arne Skerra, Ph.D., Managing Director & Chief Scientific Officer, XL-protein GmbH, Germany
Unpublished DataPK Modulation of Haptenylated Peptides Via Non-Covalent Antibody Complexation
Noncovalent antibody-peptide complexes can be applied to modulate peptide pharmacokinetics. Hapten-coupled peptide derivatives which activate the Y2R receptor were complexed with a hapten-binding antibody. Binding and signaling assays showed that modified peptides and peptide-antibody complexes retain better potency than PEGylated peptides. In vivo analyses of antibody-complexed peptides revealed improved serum half-life and weight reduction in a murine DIO model.
Ulrich Brinkmann, Ph.D., Expert Scientist, Roche Pharma Research and Early Development- Large Molecule Research, Roche, Germany
Unpublished DataXTEN - A Biodegradable Alternative to PEG Enabling Biopharmaceuticals with Precisely Controlled Structure and Valency
Amunix has developed XTEN, a protein-based polymer that mimics the biophysical properties of PEG. XTEN is easily metabolized, thereby eliminating the risk of tissue accumulation. Single or multiple payloads can be conjugated or genetically fused to XTEN which allows the generation of monospecific, bispecific, as well as multivalent biopharmaceuticals. Examples of XTENylated biologics, including two clinical programs, will be discussed.
Volker Schellenberger, Ph.D., President and Chief Executive Officer, Amunix
Networking Refreshment Break
Albumin-Binding Adnectins as PK Enhancement Solutions
Adnectins are engineered proteins derived from human 10FNIII. Using mRNA display, we identified an Adnectin that binds to human and monkey serum albumin and exhibits enhanced in vivo pharmacokinetics vs. non-albumin-binding Adnectins. Clinical PK and immunogenicity data, mechanism of action, and the utility of albumin-binding Adnectins as PK enhancement solutions for therapeutic proteins will be presented.
Tracy Mitchell, Principal Scientist, Molecular Discovery Technologies, Bristol-Myers Squibb
Platform Technologies
Unpublished DataCase StudyPlatform and Expression Technologies
The ability to engineer highly specific monoclonal antibodies into corresponding protein fragments provides a flexible platform to attach fluorescent and radioactive tracers for optical and PET imaging applications. Examples demonstrating the impact of different protein scaffolds, conjugation sites, clearance mechanisms, dosing levels and imaging schedules on the detection of immune cell and oncology targets will be presented.
Jean Gudas, Vice President, Research & Development, ImaginAb, Inc.
Unpublished DataCase StudyThe Azymetric Platform: Novel Molecular Designs for Harnessing Novel Biological Activities
Azymetric™ is a robust bispecific antibody-engineering platform tailored for the design of novel therapeutic candidates with favorable developability features, altered valencies and specificities. Azymetric based molecular designs exhibit enhanced target decoration and retention, internalization, and effector activity. Supported by in vivo efficacy studies, the advantages of the platform for a number of lytic and ADC modalities will be discussed.
David Poon, Ph.D., Director of External R&D and Alliances, Zymeworks Inc.
A Holistic Approach for Manufacturing Difficult-to-Express Proteins
Biopharmaceuticals are attractive therapeutic alternatives to classical small molecules due to their high target specificity and hence reduced side effects. However, the production of therapeutic proteins is much more challenging, and it is commonly said that the product is actually the process. Here we will present an integral approach to improve the manufacturing efficiency for difficult-to-express proteins in order to reduce cost of goods. Selected case studies will be shown for productivity and process efficiency improvement using a unique E. coli secretory system and a matrix-based screening technology for refolding of insoluble proteins.
Silvana Di Cesare, Ph.D., Business Development Manager, Wacker Biotech GmbH, Germany
Lunch on Your Own
Chairman's Remarks
Arne Skerra, Ph.D., CSO, XL-protein GmbH, Germany
Targeting Strategies and Protein Delivery Approaches
Featured Presentation
Unpublished DataEngineering of Polymeric Nanoparticles for Medical Applications
A variety of organic/inorganic materials are utilized to generate nanoparticles for drug delivery. Two most commonly used systems are polymeric nanoparticles and liposomes. Our goal is to review efforts in design and optimization of polymeric nanoparticles for medical applications, which formed the foundation for the clinical translation of the first-in-human targeted and controlled-release nanoparticles (BIND-014) for cancer therapy.
Omid Farokhzad, M.D., Associate Professor, Brigham and Women's Hospital & Harvard Medical School
Unpublished DataEfficient Delivery of Biologics into Specific Cell Types Using the Endosome Escape Trap
The efficient delivery of biologics into the cell and out of the endosomes remains a key challenge in accessing the intracellular target landscape. Most conventional CPP's are not cell specific and the vast majority of their cargoes remain trapped within the endosomal compartment. The Endosome Escape Trap enables the specific capture of those rare classes of CPP's which deliver their cargoes to the cytoplasm. Data will be presented showing that certain CPP's from Phylomer libraries can effectively deliver their cargoes which require cytoplasmic delivery for their functional activity
Richard Hopkins, Ph.D., Chief Executive Officer, Phylogica Ltd., Australia
Unpublished DataTargeted Delivery using Nanoparticles
Targeted nanotherapeutics provide an attractive alternative to traditional ADC's, in part due to their large size, multivalent display of targeting ligands, and considerable capacity for encapsulating small molecule drugs. Clinical translation of the first of these targeted nanoparticles has given rise to a new drug with a favorable toxicity profile, long circulating PK, and initial evidence of antitumor activity.
Daryl C. Drummond, Ph.D., Senior Director, Nanotherapeutics, Merrimack Pharmaceuticals
Networking Refreshment Break
Case StudyCDR-Restricted Engineering of Native Human scFvs Creates Highly Stable and Soluble Bi-functional Antibodies for Subcutaneous Delivery
In this study, we engineered a tetravalent scFv-Fc-scFv molecule, targeting two immunomodulatory targets, the soluble chemokine CXCL13, and a cell-surface inflammatory antigen. We demonstrated for the first time that, when native, human scFvs are aggressively optimized to func¬tion in that format, the high concentration formulation required for subcutaneous delivery of scFv-based bispecifics and low-fre-quency dosing is an achievable goal.
Brian Fennell, Ph.D., Principal Scientist and Research Group Leader, Global Biotherapeutics Technologies, Pfizer Inc.
Unpublished DataPhoto-Immunotherapy (PIT): A Unique Highly Cancer Cell-Specific Therapy Inducing Immediate Necrotic Cell Death Followed by Enhanced Nano-Drug Delivery and Immunological Response
Photo-immunotherapy (PIT) is a newly developed molecularly-targeted cancer photo-therapy, which is based on conjugating a near infrared photosensitizer, IR700, to monoclonal antibodies targeting cancer-specific cell-surface molecules. PIT damages cell membrane to induce rapid necrotic cell death, results in dramatically enhanced nano-particle delivery to cancer tissue and elicit host immunity, therefore, PIT can treat contaminating target-negative cancer cells and overcome inhomogeneity.
Hisataka Kobayashi, MD, Ph.D., Chief Scientist, Molecular Imaging Program, NCI/NIH
Screening for Antibodies that Target the Blood-Brain Barrier
The blood-brain barrier presents a substantial obstacle to brain drug delivery. To help address this issue, we have recently developed a variety of antibody screening and engineering tools specifically designed with the blood-brain barrier in mind. New screening paradigms and resultant antibodies that have preference for the brain vasculature will be discussed.
Eric V. Shusta, Ph.D., Professor, Chemical and Biological Engineering, University of Wisconsin-Madison
Close of Conference


text:
*LA native* I'm a bass playing, bike riding, (speed)skating, lover of music, art, and low frequencies.
Face Tags
Artist info for #Frida!
"Sol y Vida/Sun and Life" 1947. The colors in her paintings are SO much more vibrant than ANY book I've ever seen
Original programme from Frida Kahlo's first solo show in 1938. #Frida!
Veggie platters make me feel like a happy rabbit. Mmm mmmm!
#SavePickFairStudios Protesting doggy has his own sign. Woof!!
Officials in Baltimore say one of these two people could be the winner of the Mega Millions.
(How) can I get one of these when they come down? @LACMA #frida
Sorry, but I think this is too much. This guy was eating a pizza, has drinks, and is now snoring @weholibrary #NotCool
I wore this shirt all day yesterday and for the first time, did not get a single comment!? I'm losing my touch!
Followed the LA Marathon to the finish line in Santa Monica. "Damn right it was a good day."
Santa Monica, I've missed you!!!
When else would I be able to ride in the middle of Santa Monica x Avenue of the Stars like this!? Wheeee!!! #LAMarathon
LA Marathoners running past Beverly Hills fire station, city hall, and 9/11 memorial. It's a pretty day to be outside.
@misssleepy77 I took a pic for you today :) View of Pacific Design Center from WeHo library. I bike that street evrydy
Looks like this will be the behemoth *awesome* contraption that's going to lower the @LACMA rock over the trench.
The transporter looked amazing. It's HUGE! What awesome engineering. Oh yeah, that's the rock on the left...eh.
If this was my dog, I'd name it "Killer", middle name "Fro".
He chained down thunder n handcuffed lightn'g. He's so damn strong it's sometimes frightening - My Human Tornado shirt!
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text:
13201 Clayton Rd,
Saint Louis, MO, 63131
Saint Louis, MO, 63131
Tel: (314)434-2100
The Purpose of the Principia School and policies of an institution are its basic foundation for progress and usefulness.
Purpose is vision of the goal to be attained; policies are the plan of action or ways of administration by which vision is to become accomplishment.
Be it, therefore, Resolved, that as the result of many years of experience and prayerful consideration by its Trustees under the active leadership of Mary Kimball Morgan, the purpose and policies of The Principia shall be as follows: The primary purpose of The Principia is to serve the Cause of Christian Science.
School Overview
|School Membership(s)School Assoc.
|National Association of Independent Schools (NAIS)
Other school association(s)
|Religious Affiliation
|Grades Offered
|Grades Prekindergarten - 12
Student Body
|Total Students
|465 students
|Student Body Type
|% Students of Color
State avg.: 15%
|Students by Grade
Academics and Faculty
|Total Classroom Teachers
|67 teachers
|Student : Teacher Ratio
National avg.: 13:1
Nearby Schools:
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Saint LouisChristian Brothers College High School
1850 De La Salle Dr
Saint Louis, MO, 63141
(314)985-61001.1 mi | 801 students | Gr. 9-12
All-boys (Roman Catholic)
Saint LouisThe Moog Center For Deaf Education
12300 S 40 Dr
Saint Louis, MO, 63141
(314)692-7172Special Education School1.3 mi | n/a students | Gr. PK
Saint LouisChurchill Center & School
1021 Municipal Center Drive
Saint Louis, MO, 63131
(314)997-4343Special Education School1.3 mi | 116 students | Gr. 1-10
Saint LouisRossman School
12660 Conway Road
Saint Louis, MO, 63141
(314)434-58771.5 mi | 230 students | Gr. PK-6
Saint LouisSt Louis Priory School
500 S Mason Rd
Saint Louis, MO, 63141
(314)434-36901.5 mi | 447 students | Gr. 7-12
All-boys (Roman Catholic)
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Updated October 26, 2014
What do you do when you are dissatisfied with your local public schools? Homeschool your children? Send them to private school? Let's look at your options.
Your religion matters to you. You want your child to attend a school which will combine academics and religious education. Here is an overview of what is available together with some links to denominational web sites.
Add things up and you'll quickly find the answer- math is crucial both in academics and the real world. By following these strategies and following personal training programs, students can uncover their weaknesses and conquer math.


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Pink Inn
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Wet and dry
... min. with a crowd of tourists. The driver came in, started the engine and we were on our way up.... right? Wrong! A quater of the way up the driver suddenly stopped the bus, got out, walked towards the back, came back and said: everybody out ! One of the rear carriage had a flat tyre. There were no other solution but to walk back to the point of departure and starting walking up ...
Getting Off the Boat
... assembled some solid sandwiches with pesto, tuna, mayo, salami, tomato and rocket - almost up to scratch with our boat meals. We watched some Adventure Time and a little Spy Kids 3, killing time by doing absolutely nothing. It was amazing. For dinner Matt whipped a huge batch of Spanish omelet which was delicious and filling and we ate around the table like a family before having a Shark Week marathon before bed. Going to sleep in a bed I could actually sit up in was the best thing ...
Zadar zizzles
... to give it a miss. However this guy spoke a bit of English and so we embarked on a bargaining session with him. He had a good sense of humour and we hustled him for the best deal – we ended up being able to get a really nice pair of little coral rosebuds with a gold backing with a pair of silver backed ones included in the deal at what we thought was a good price provided we paid in cash. Trouble was that none of us had been to the ...
... made a fishing net that did not work well. We had so much fun. After a long time we went back to the boat and got dry and ready for lunch. The two sailors both made some prawn risotto with a cucumber and tomato salad. I enjoyed the lunch a lot and had 2 serves of it. I then went to the front of the boat to look at the fishes swimming around. The water was very clear and you could see the bottom very easily. Then we got some bread and chucked it ...
Celebration - Today Croatia joins the EU
... to find a cafe and drink coffee. I must admit, I am missing my grande non-fat latte a bit. The coffee is wonderful but served in micro small cups. After a family style dinner we end the evening up on the top deck where Zoe and Isaiah entertain us with a soccer match. My nephew has gotten so good that I don't think I have been able to steal the ball from him when I jump in for an impromptu go at it. Zoe has finally found the Croatian soccer jersey ...


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David, I have one known Henion ancestor: Margaret Henion, b. 1795, married John P. Sloat (no known b. or d. dates); Margaret Henion d. 7/29/1879. Margaret and John had a daughter, Rachel Sloat, b. 1/24/1838. May have had other children. Rachel married John Tice (b.12/5/1836, d. 4/21/1873) on 12/6/1856, had 6 children of which one was my grandmother. After the death of John Tice, Rachel remarried a man named Conklin and had one son, Arthur S. Conklin. Rachel d. 2/10/1912.
Family lore (unconfirmed) held that these Sloats were of the family that settled Sloatsburg, NY (Rockland County). This Tice family was from "Pompton, Bergen County NJ" (note, the present day town of Pompton Lakes is in Passaic County). Many of them are buried in the Pompton Lakes Reformed Church cemetery. So these folks were in the area of your Henions... it's likely that my Margaret may have been part of that clan. Any clues would be much appreciated! Thanks.
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Twitter posts: Tim Ferriss, end of the world, and gold
5 Comments- Get free updates of new posts here
Each day, I post short insights on http://twitter.com/ramit about psychology, testing, personal finance, investing, the best links I've found, and stupid people.
You won't find these on my blog.
Here are a few of my favorite recent tweets:
I'm interviewing Tim Ferriss at the Apple Store in Soho this Thursday, 6:30pm. Open to the public: http://bit.ly/iFIOH6
The Tim Ferriss event is TOMORROW, 5/26. If you're in NYC, drop by.
In 1954, a group predicted the end of the world. But a social psychologist infiltrated the group. Here's what happened: http://bit.ly/kGwXJt
Great talk by @charliehoehn on how to get a dream job — he worked with Tim Ferriss, Tucker Max, and me: http://bit.ly/kYurz0
Great (and insanely researched) post about investing in gold by @jdroth: http://bit.ly/izHChv
This is why you do not take investment advice from random, anonymous internet commenters: http://bit.ly/kmm4Xc
Really interesting thread about all things McDonalds, including secret things to order, profit margins, gross stories: http://bit.ly/lq34mM
To get all of my Twitter updates as they happen, follow me here: http://twitter.com/ramit
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|The UNSIS 9a.m. fashion show
To practice clothes vocabulary my classes recently did a fashion parade. Tasks like these take an inordinate amount of time to set up - teaching the vocabulary, and trying to get them to be more imaginative and forthcoming. They don't get to do a lot of things like this in other classes so they are usually a little perplexed as to why we are not just listening and copying.
I did my best pout and catwalk prance to show them that it's more fun when you get into it. I also encouraged them to wear their glad rags even if their wardrobe choices are a little limited. Many of them obliged and wore something different. A couple of them even invented imaginary accessories which was good. However, I'm not sure that 'Paris Hilton diamonds' actually exist.
Their command of the language was predictably iffy, and their preparation was even worse. Some of them had memorised their passages well, although most students just frantically looked at what their partner was wearing and blurted out things like "pants blues" or "esweater Hollister". This lead to the poor models having to walk up and down the catwalk about 55 times! Luckily no one stacked it.
One strange thing to come up, is that almost everyone wore Oggi brand jeans. I don't know why Oggi is so popular amongst Mexico's youth, but it is. Some Italian designer is pouring another glass of prosecco for themselves. Oggi (pronounced Ojji) is Italian for today, although every student insisted on pronouncing it 'Oggy'.
"She is wearing the Oggy jeans very nice. She is bought Oggy jeans in market of Oaxaca".
It made me wonder if the pockets were filled with Cornish pasties, or if Gareth from the office was a brand ambassador.
I kept the 'models' on stage for a minute to ask them questions about their outfits which normally transformed into lengthy anecdotes about Oggy jeans, but it did give me the opportunity to crack some bad fashion jokes.
"Who's that at the door? Oi Javier, the fashion police are here to take you away."
"You spent $500 pesos on those shoes and you moan about spending 50 pesos on an English book!"
It was good to do something tailored towards girls, as the majority of students are feminine. I guess it was a good example of showing them that something can be fun, and even make believe rather than drab gap-fil exam based assessment. Oggy Oggy Oggy!
Architect of my own downfall:
With very little banter coming back from my students, I often have to keep myself amused in class by including silly phrases, names or sentences in my texts and examples. This however, regularly bites me in the ass.
"Barry Pinches is a snooker player from Norwich . . ."
"Teacher, what means Pinches?" "It's a surname"
"Teacher, what means Barry?" "It's a name"
"Teacher, what means esnookerr?" "It's the sport Barry Pinches plays"
"Who is the Barry Pinches" "A snooker player!"
"ahhhh, OK . . . what means Norwich?
Students aren't good at picking up on proper nouns and will ask about names and places all day, and just like that Barry Pinches has derailed the class.
I also like to force them to ask in English by mimicking them and saying:
"Qué signífica 'Qué signífica'?"
"Cómo se dice 'cómo se dice'?"
One of my classes finds this little game so funny they deliberately ask in Spanish and we just go back and forth for about five minutes saying "Qué es, qúe es?".
Generally, when my students ask how to say something, it is to ask me or tell me something obvious. I can see their little games coming from a mile away.
"Como se dice 'quemado' teacher?" "Sunburned"
"You is sunburned teacher"
"Como se dice 'peinarse' teacher?" "Brush your hair"
"Teacher no brush your hair today"
"Como se dice 'lentes' teacher?" "Glasses"
"Where you glasses teacher?"
In fact, letting them in on any part of your private life always leads to a stream of inane comments and questions. I showed them a picture of my cat the other week which they liked, but they just bring it up at the wrong moment.
"What did you do last weekend Itzel?" "How is the Nacho teacher?"
One student even claimed that Nacho ate his homework! I guess we do have a little banter sometimes.
Board stiff:
|More fashionista
I'm not really the right person to criticise them as my writing isn't neat, but theirs is illegible. Watching them write a sentence is painful, as they 'um' and 'ah', rub out words with their hands (instead of the board rubber) and scrawl word-like constructions onto the white surface.
I have to mark where to write for them too otherwise, they overlap each others writing or even go off the edge of the surface! I often forget that I'm a little taller than them too. Some of the girls can't reach above the midway point of the whiteboard!
The class always shout out instruction to the student scribe too. It goes back to them thinking that the answer is EVERYTHING. We played a game of 'telephone' (Chinese whispers) the other day, and they were all trying to break rank to tell the writer at the board what the phrase was.
One particularly odd incident happened when a student was handing me back a marker pen after finishing writing. She took the lid of the pen, looked me straight in the eye, held my gaze and took a deep sniff of the nib.
"Well that was weird" I said, turning to the class.
What have you never done?
I set this homework task last week and it turned up some interesting results. I left the structure of the answer open. They could write basic sentences, say what they would like to do in the future, or even use abstract answers.
I was expecting them to write things like "I have never travelled in an aeroplane", and to be fair, some did. Here are some of the more interesting responses though:
- "I have never danced with a bug"
- "I have never watched a alien because I have fear"
- "I've never eaten mouses" What, the computer controllers?!?
- "I have never uploaded in dragon"
- "I have never eaten suckling pig, because I have thought it have been a little baby" What about the beef tacos you just ate?
- "I have never grugged" Me neither, what is it?
- "I have never done a cake because my mother is a very chef."
- "I have never cooked because my mother never taught me" A brilliant abdication of responsibility.
- "My mom says that I should eat garlic but i have not tastes it because it smells ugly"
- "I have never eaten monkey in Chiapas" which was wonderfully detached from the preceeding sentence of "I've never been to a concert".
- "I have never fallen in love. I prefer eat pizza" Finally, something we can agree on!
It's always interesting gaining an insight into their lives although it's a shame that they are so insular. Most answers were centered around having no money or putting off doing things until they had a job. If you really want to travel, you can hitch hike and couch-surf for free.
One student did write a good essay on copying others in society and how he hadn't lived. I guess you only need to get through to one of them to make a difference.
Bits and Bobs:
A few miscellaneous things which have brought a smile to my lips recently are:
1. Telling the students that they have one a 'special prize', then giving them a handshake and a sincere "Well done" after rummaging around in my bag pretending to look for the prize.
2. Seeing how they spell my name on exams. This time we had 'Feel', 'Fillp' and my personal favourite 'Philly'.
3. I have enjoyed countering the daily cries of "Movie teacher? Movie teacher?" with this (which I say in Spanish)
"If you can ask me if we can watch a movie correctly in English, we will watch a movie". . . student thinks for 60 seconds.
"We can watch movie in class today?""NOPE - incorrect, it's can we watch a movie in class today. Better luck next time!"
4. Taking the piss out of my 9a.m. class who always bring breakfast to class. I always go around the class asking them how their food is.
"Have you got your vanilla milk today Irais? Yep, she's got it!"
"Apple yoghurt and a torta for Misael again? Of course . . ."
One of them even sells homemade pancakes at 5 pesos a pop which is very industrious and useful if I've missed my breakfast!
4. Three students in my 1pm class who are course mates and friends always squeal on each other.
"No copy! she copy teacher!!!"
"Cellphone teacher!"
I call them 'Los tres soplones' (the three snitches), which they seem to find funny, although it only encourages them to squeal even more.
5. One of my classrooms adjoins the bathroom and you occasionally get loud water-based hisses through the wall. One of my students convinced my that there was a snake in the classroom and I bought it because she was acting so concerned and pointing to my bag. I've had enough experience with creepy crawlies in the Istmo to not take this threat too lightly so I carefully peered into my bag.
Que the laughter . . .
I guess you can't wind them and win ALL of the time.


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Dining & Nightlife
FEATURED STORY | Read more Featured Dining & Nightlife articles
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As a triathlete, Michael Esposito knows the physical grind of a long race: The focus, determination and tenacity to keep going. The 45-year-old Seaford native sticks to a strict daily regimen of running and biking, and swims several times a week. The plan keeps him fit in body and mind. And that mental fitness came in handy this summer at the World Series of Poker. Read Full Article
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Art of Fresh - Out This World
Artist: Art of Fresh
Producer: Slakah the Beatchild
Album: Back to the Earth
Avg Rating: 3.5 ( 19 votes )
I can't even watch tv for nine hours straight, so when I heard Canadian born rapper D.O. had freestyled for nine hours straight, earning him a Guinness World Record, I was more than a little impressed. But freestyle endurance isn't the only thing going for the man: D.O. and his musical compatriot Slakah the Beatchild (who handles most of the production work) also form Art of Fresh, a genre-bending crew making their DJBooth.net premier with their new track Out of This World. Behind the boards Slakah puts together a sonic patchwork that's part disco, part hip-hop and all head-nodding energy, while D.O. grabs the mic for rhymes that are as intelligent as they are catchy (Slakah even throws in some vocal contributions of his own). Out of This World may catch some off guard, but personally, I'm digging the originality. If you want more boundary defying action from Art of Fresh, keep an eye out for their upcoming album Back to the Earth, which currently had no release date.
Written by Nathan S. on 11/9/09
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"Good Shoes" (2011)
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Post-Katrina crime drama K-Ville
Fox's new K-Ville has sparked a fierce debate over the line between truth-seeking and exploitation. Who on Earth thought filming a show in post-hurricane New Orleans was a good idea? said Robert Bianco in USA Today. Come on, said TVParty.com. The "un
Fox last night launched a TV crime drama—K-Ville—that has sparked a fierce debate over the line between truth-seeking and exploitation. K-Ville is filmed and set in post-Katrina New Orleans, and some critics are praising the show for setting up shop in an area that desperately needs a boost to its economy. But others say it's a cheap attempt to cash in on the Gulf Coast's misery.
Who on Earth thought this show was a good idea? said Robert Bianco in USA Today. "It's possible America is ready for an overheated, buddy-cop throwback to Starsky and Hutch, or for a pulp drama set in New Orleans—though my bet is that it's too late for the former and too early for the latter." That this show combines both makes matters even worse. And not only is the timing of this show bad, it's also in "excruciatingly bad taste."
There are good things and bad things about K-Ville being filmed in New Orleans, said Bill Carter in The New York Times (free registration). On one hand, it has given a boost to the local economy, provided lots of new jobs, and allowed "New Orleans to reclaim some attention from a nation that seems to have moved on to other concerns." But on the other hand, it means building scenes "around abandoned homes, glimpses of still-present piles of debris and story lines that inevitably focus on crime: something that New Orleans continues to have in abundance."
The fact that K-Ville is shot in New Orleans only adds to the show's appeal, said TVParty.com. The "flood ravaged" city "makes for an unsettling locale for a cop show." Serving to intensify the mood is the "wobbly, hand-held action," which further captures "the uneasy flavor of the Big Easy." This is one of the best shows of the fall TV season.
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Ronald McDonald House and Friends Celebrate
Ronald McDonald House Charities (RMHC) of Richmond celebrated its 30th Birthday Party with a Sept. 27 gala at the Westin Richmond, featuring silent and live auctions and gourmet tastings provided by local restaurants. The two-day celebration, which included a golf tournament and represented the biggest fundraiser of the year for RMHC Richmond, raised approximately $175,000. Among the guests and volunteers who paused for a photo beneath the giant birthday cake were (above, left to right) Linda Handzo, event committee member; Susan Durlak, event chair and McDonald's franchisee; Ronald McDonald; Lori Costa; Karen Brimm, event volunteer; and Lynne Fye. For details about RMHC, visit richmondrmhc.org.
MADD to host candlelight vigil Dec. 2 at UR
Mothers Against Drunk Driving (MADD) will host a candlelight vigil of remembrance and hope Tuesday, Dec. 2 at 7 p.m. at the University of Richmond, outside the Cannon Chapel. The public is invited to attend and join MADD to honor victims of impaired driving crashes, while helping to remind the community to be safe during the holidays. > Read more.
Tournament supports adoption efforts
Among participants at the Seventh Annual Coordinators2Inc Golf Tournament and awards luncheon Oct. 3 were (from left) Rebecca Ricardo, C2 Inc executive director; Kevin Derr, member of the winning foursome; Sharon Richardson, C2 Inc founder; and Frank Ridgway and Jon King, members of the winning foursome.
Held at The Crossings Golf Club, the tournament will benefit placement of children from Virginia's foster care system into permanent families through Coordinators2. > Read more.
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Event will help kick of Marine Corps' 'Toys for Tots' campaign
All 140 A.C. Moore locations will serve as drop-off centers this year for the Marine Toys for Tots Foundation, and all toys collected will stay in the local communities served by the stores in which they are donated.
On Saturday, Nov. 15, the Willow Lawn location will kick off the month-long program by hosting a "Make & Take" craft event for kids. Children ages six and older will be able to make a craft and take it home with them. Representatives from the Marines will be in-store to teach customers about the Toys for Tots program. A.C. Moore team members will be on site to help with the crafts. > Read more.
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Weekend Top 10
The Dominion GardenFest of Lights Grand Illumination takes place tonight at Lewis Ginter Botanical Garden! This year's theme is "A Legacy in Lights: 120 Years from Bicycle Club to Botanical Garden," which celebrates the Garden's history. You can also celebrate Thanksgiving again – tomorrow at Henricus Historical Park. More great events – Lavender Fields Herb Farm and Wilton House Museum will both host their holiday open house events this weekend. For all our top picks this weekend, click here! > Read more.
A hero is born
Disney's 'Big Hero 6,' lovable robot Baymax delight
It may be time for Olaf to step down as our nation's reigning cartoon character. Big Hero 6, the latest animated feature from Disney, contains a challenger to the throne: Baymax (Scott Adsit), another lovably chubby white wonder, who will bring joy to children's hearts and invade every home in America inside a six-foot pile of Disney merchandise.
Big Hero 6 (based ever so slightly on a Marvel comic of the same name) is the story of Baymax – and also his closest companion Hiro Hamada (Ryan Potter). And then also their four friends, all of whom join together to form the titular superhero team.
At first, though, it's only Hiro, a young boy and an engineering prodigy, who'd rather spend his time in underground robot fight clubs than do something productive with his gifts. > Read more.
Authentically Italian
Bella's feels – and tastes – like Italy should
Short Pump is known for its share of chain restaurants and strip malls, but diners looking for something more distinct can certainly find it without heading downtown or to nearby Charlottesville.
In fact, local husband-and-wife restaurateurs Valeria Bisenti and Doug Muir brought a taste of Charlottesville (and Italy) to Short Pump when they took a chance and opened Bella's second location in the same shopping strip as Wal-Mart and Peter Chang China Cafe. (Bella's original location is on Main Street in downtown Charlottesville.)
For a local Italian restaurant, Bella's is as "Mom and Pop" as its gets. Valeria is Mom, and Doug is Pop. Since its opening about six months ago, diners have been eating rich comfort foods and drinking Italian wines. > Read more.
Varina District meetings to highlight road projects, Virginia Capital Trail, new library
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Nov. 20, 2014Click here to read the print edition.
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CalendarHenricus Historical Park will hold "Virginia's Thanksgiving Feast and Prayer" from 10 a.m. to 5 p.m. Visitors are invited to learn about the real meaning of Thanksgiving, which was recognized… Full text


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Before John Was A Jazz Giant
A Song of John Coltrane
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Authors: Weatherford, Carole Boston, 1956-
Title: Before John was a jazz giant
a song of John Coltrane
a song of John Coltrane
Statement of Responsibility: Carole Boston Weatherford ; illustrated by Sean Qualls
Edition: 1st ed
Publisher: New York : Henry Holt, 2008
Branch Call Number: EB COLTRANE
Characteristics: 1 v. (unpaged) : col. ill. ; 26 cm
Summary: This lyrical picture-book biography of John Coltrane focuses on his childhood and how he interpreted sounds before he made his music.
Subject Headings: Saxophonists United States Biography Jazz musicians United States Biography Saxophonists United States Biography Juvenile literature Jazz musicians United States Biography Juvenile literature Coltrane, John, 1926-1967 Coltrane, John, 1926-1967 Juvenile literature
Genre/Form: Picture books for children
Topical Term: Saxophonists
Jazz musicians
Jazz musicians
Jazz musicians
Jazz musicians
Additional Contributors:
ISBN: 0805079947 (reinforced)
9780805079944 (reinforced)
9780805079944 (reinforced)
Awards & Distinctions: A Junior Library Guild selection
Bibliography: Includes bibliographical references
Study Program: Accelerated Reader/Renaissance Learning LG 3.8 0.5
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Showing 27 reviews for Pioneer TS-D6902R
|Customer Review Summary for Pioneer TS-D6902R
|January 7, 2012
|BEST 6x9s for mid and highs peroid!
1 of 1 people found the following review helpful:
Review by
Derrick from greene county, TN
I had 8 of these in a 92 civic and it was clear and loud. These things produce loud, clear and very crisp sound when amped. I did not have any subwoofers in the car and my friends couldnt beleave that there wasnt 2-10" subs in the car!
|August 3, 2011
|No Hype, Just Good Sound
1 of 1 people found the following review helpful:
Review by
Audio Guy from Valencia, CA
I design professional audio equipment for a living. When I was looking for a set of 6" x 9" speakers for my hot rod, I wanted good sound, but not a lot of sales hype. Most of the speakers around are 3, 4 and 5 way deisigns. That sounds great for marketing, but who needs 3 tweeters? These Pioneer TS-D6902R's are just simple 2-ways. I installed them, and I am super happy with the results. Great overall sound, good bass and highs. I have recomneded these to several friends and they have been happy too. You won't be disapointed!
|October 20, 2014
|No sub needed for me with these speakers
Review by
Vinny from Cranston, Rhode Island
Running these amped with 75watts rms X4 with a Pioneer DEH-80PRS and Pioneer TS-D1720C fronts. Crystal clear sound and plenty of base for me when the head unit is tuned properly. With this set up I hit ear bleed levels at 38 out of 62 on the volume. I can't see adding a sub with the amount of base that this set up produces. Hard hitting. Rear and side view mirrors start to shake at level 30 on the volume. No distortion at 38. Played Metallica until it sleeps at 38 shook the whole car. Totally awesome to be able to play my music loud and clear.
|September 13, 2014
|Great product for a great price
Review by
Scott from Bradenton, FL
I bought these along with 2 pairs of the Ts D1602R's for my 2014 Toyota 4runner hooked up to an Audio Control Lc7i, Alpine PDX-5 and an Alpine type R 10" sub in a ported box. The Pioneer's are a great factory replacement, loud and clear. But i would recommend an amp be hooked up to them for best sound. Customer service were very kind and a great help!
|September 5, 2014
|good speaker
Review by
jarrod from Ruston, LA
this is a real good speaker to have it hit hard thanks sonic electronix
|July 29, 2014
|TS-D6902R (TS-E6902i)
Review by
Olav from Sulitjelma,, Norway
Very good sounding speakers
These are my daily use rear-speakers in my current setup.. i'm very satisfied by the sound quality and loudness these speakers are capable of, running directly from the head unit (which is an older Pioneer unit)
If I want to just listen to music without the need for subwoofers, I'd set the EQ properly and enjoy the good balanced sound..
By my taste of music, these speakers play loud but soft, and the listener's experience is very good!
Who needs a 3 or 4-way "by-nine" when a good sounding 2-way is much better :)
|May 26, 2014
|Amazing Bass!
Review by
RM from IL
Wow these things make my rear view mirror shake! They provide just enough base to satisfy the ears yet not crazy like actual subwoofers. Still there is enough clarity to hear the music clearly. These were simply drop in and install for my 03 Altima's rear deck. No drilling or adjustments required. Would recommend these to anyone looking for lots of base and not crazy subwoofer like base.
|April 21, 2014
|bang for the buck
Review by
boB from Clarkston, Michigan
Can't be beat...
Totally more detailed sound...I hear thing's in my music I have never heard before.
Component speakers are the only way to go! :-)
|January 16, 2014
|Well worth every penny!
Review by
Foghead from Lockport, NY
Just installed these yesterday and am VERY impressed with the clarity and neutral response. They're currently installed under the original deck material - I feel the highs would open up considerably if the tweets were fully uncovered and the provided grills were utilized (will do this when the weather warms up some). They're being powered with an older Alpine MRP T220 amp at 55rms/side and this provides fairly solid bass and clarity (a larger 4ch amp is also coming @ 100+rms/4 for a little extra headroom - I've had the matching series of these in 6x8 in the front doors as well for over 7 months, hence the reason for a 5-star rating for durability). Bass will also improve as the speakers break in as these surrounds are pretty stiff. All in all though, these speakers are a killer deal if you're only wanting to run full range speakers. Details, clarity, neutral response, reasonably solid bass... they can't be beat at this price!
|September 18, 2013
|good compact amp
Review by
big smokeeyyy from bama
This amp is just a great amp, I'd recommend to anyone!
|August 6, 2013
Review by
Chris from Lincoln, NE
Can't go wrong with sonic prices for the product you get. Nice 6x9 for the price when i first hooked these up they were running off the deck and they sounded pretty good. But when i ran 'em off my old school alpine v12 they just started screamin'. Bass and mid range was all around good quality and the highs were same also after some adjustments. Hook 'em up to a good quality 4-channel for best outcome in my opinion. Had 'em running for a couple of months now and sounds like they will last awhile.
|May 3, 2013
|Get them
Review by
Blackciti from Chicago, IL
I have these in my 99 grand prix and they sound good. There is no bass though but that is because I have them hooked to a 4 channel pioneer amp and that amp is set up to work as a highs amp. I am getting subs for my bass. The clarity is very good and I can't turn the volume too high or it will become unbearable lol.
|October 29, 2012
|Great 6x9 Speakers
Review by
Maximum Al from Grosse Pointe Park, MI
I purchased these for a boat application. The way they are mounted they are inside a covered area and the tweeters are pointing at your knees. In spite of this the highs are clear and smooth with excellent bass. In a loud and open boat it's hard to worry about imaging or really anything but volume. I have been impressed with how capable these speakers have been. I have 50 watts going to each one. They are plenty efficient. Really the best 6x9s I've ever owned.
|September 12, 2012
|Best Ever...
Review by
KEVIN D from Metro Detroit, MI
Power handling, clarity, crisp clear highs, the woofer handles the bass better than most smaller subwoofers! Only thing I noticed was that in order to get that bass you need to use an enclosure for them. The bass response out of the box was ok- decent, however, when I put them in a small enclosure (.5sqft/ speaker) the bass was incredible. Just wish I would've found out about the D series from Pioneer a long time ago!!! Definitely Recommend for anyone- with or without using an amp (just dont forget to use the enclosure to get your moneys worth and then some)!!!
|August 8, 2012
|perfect fit
Review by
ltsplay from N,H,
I wasn't a fan of pioneer but bought these because of the spec's for my saab and they sound exellent. I do not have them amped but will soon and that should really bring out the features of this speaker. Bottom line there worth the money.
|April 15, 2012
|Awsome!!! :)
Review by
Jose from Dallas, Tx
These speakers are the beast I had ever owned, good price, no body can beat the price that Sonic electeonix has. I 100% recommend these speakers, you would love how it sounds.
|July 11, 2011
|Awesome product
Review by
Plunda from MIami
Had this item for the past 7 months and still going hard everyday in my car, glad I purchased from these guys.
|July 5, 2011
|Pioneer TS-D6902R
Review by
gz from phila pa
Works great and looks great in my 1973 Challenger rt
|June 4, 2011
|Wonderful speakers
Review by
Barrett from Marion, AR
I have a Quart reference 4.80 amplifier powering these speakers and the 2010 version Rockford Fosgate Punch 6X9" 2-way coaxials. It is the best setup ever. I am getting a 12" sub to balance out the mids and highs that these beasts unleash, but I can definitely say that these speakers hit harder than four 8" subs. It feels like you are being punched in the chest when they hit. Seriously amazing speakers. Just make sure you have the amp to power them.
|May 12, 2011
|good deal
Review by
lee from san diego ca
Great speaker and a great price
|May 10, 2011
|good speakers
Review by
daniel from albany, wa, Australia
These speakers are great. They can take a good hammering and go very loud and at the same time stay clear and precise. you will be suprised how much bass they can thump out up loud.. they need a good amp because a head unit wont be able to compliment them.
|May 5, 2011
Review by
Ulugbek from Brooklyn, NY
These speakers simply awesome,I would recommend these speaker!!!!!
|April 5, 2011
|Pioneer TS-D6902R Speakers
Review by
Steve from Farmington, MN
These speakers are simply awesome. I installed them in the front door of my RAM 1500 and they thump. They are connected to a 4x600 watt pioneer amplifier and I am amazed with their performance. I would recommend this product to any interested in rocking out in their vehicle.
|October 26, 2010
|Awesome Speakers
Review by
Panda from Sacramento
These speakers are awesome. I recommend hooking it up to an amp. Other than that, they are good quality and money worth.
|March 25, 2010
|these speakers get LOUD
Review by
Ben G from chicago, IL
man these speakers get loud and clear, I have 4 of them on a 4-channel amp and i can hear my car as if im sitting in it, when the music is playing and I have the car parked on the street, and I'm sitting in my garage, its crystal clear. Good mid bass and nice tweeters
|December 26, 2009
|Best thing going
Review by
Tom from Tofino, BC, Canada
I really like the Pioneer sound and have been running these speakers on my boat inside my cabin with a DEH-P310UB stereo head. The sound is realistic, clear and powerful. The speakers deliver an amazing amount of bass, clear treble and really give the listener a feeling of being enveloped in the toons regardless of being pumped up on a Friday night or toned down on a Sunday afternoon. Highly recommended, excellent price at Sonic.
|July 11, 2008
|Good speakers
Review by
john from Mount Prospect, IL
Good specs, good sound. I have these speakers powered by Profiles' AP1040. They have pretty good bass and ok mids and highs.


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2555 North Clark Apartments2555 N Clark St, Chicago, IL 60614 View On Map (773) 529-2524
For rates, availability, and other information fill out the availability request form and a representative from 2555 North Clark Apartments will contact you shortly
2555 North Clark is located in the Chicago Area in the 60614 zip code. View this apartment on a map.
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Posts tagged jacksquat
This week on XBLA: Absolutely Nothing
Video: GSB News: XBLA Forecast Microsoft must be running low on original ideas as this week, Absolutely Nothing is making its way to the Xbox Live Arcade. As a sequel to the critically panned Jacksquat, you would think that Microsoft would wise up and stop trying to shove this property down our ...
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WWE 2K15 review: Disqualification match
Posted on Nov 26th 2014 2:00PM
Tales from the Borderlands Episode One review: Busy earnin'
Posted on Nov 26th 2014 9:00AM
Assassin's Creed Rogue review: Avast ye, clone!
Posted on Nov 25th 2014 9:01AM


text:
Joaquin Phoenix
He's known for portraying eccentric characters on the big screen, and it's quite possible that Joaquin Phoenix pulls inspiration from living with the Children of God religious group when he was a child.
In a recent interview with Playboy magazine, the "Master" actor opens up about joining the group, which critics have called a cult, with his parents.
She's certainly compiling an impressive resume, and Emma Stone kicked off another work week on the set of the new untitled Woody Allen project on Monday (July 28).
Joined by costar Joaquin Phoenix, the "Amazing Spider-Man" starlet looked pretty and playful as she meandered around a Newport, Rhode Island park in khaki green shorts and an embellished white top.
With Comic-Con underway, there's plenty of hype around upcoming superhero movies and one unlikely character is being thrown into the rumor mill.
According to reports on Friday (July 25), Joaquin Phoenix is eyeing up a role in a brand new Marvel movie.
Rightly proud of their latest work, Joaquin Phoenix and Marion Cotillard showed up at the premiere of "The Immigrant" in Manhattan on Tuesday evening (May 6).
The handsome "Walk the Line" actor was unusually outgoing with fans and press while posing for pictures outside the Paley Center for Media.
Her career just keeps getting hotter, and Emma Stone's newest gig puts her under the direction of living legend Woody Allen for the second time.
The "Amazing Spider-Man 2" dame will join recently-announced costar Joaquin Phoenix for the untitled project when filming begins this summer.
Creating a wonderful collaboration, Joaquin Phoenix is officially set to join Woody Allen's newest film.
At the current moment, there are no further details regarding the flick but it is reportedly scheduled to stat production in July.
It's one of the most critically-acclaimed indie films of its day, and "The Immigrant" is gearing up for limited release on May 16th.
The James Gray flick stars Joaquin Phoenix, Marion Cotillard and Jeremy Renner and has already created quite a buzz at film festivals in Cannes, Zurich and New York City.
She has a well-established appetite for male affection, and Lindsay Lohan'ss list of bedfellows appears to be long and distinguished.
Per a report from In Touch magazine, the "Mean Girls" star kept a roster of the guys she's boffed, and back in January she shared the record with some gal pals.
Taking a break from their usual duties, Matt Damon and Joaquin Phoenix headed over to the Beverly Hilton for the 71st Golden Globes earlier tonight (January 12).
The "Behind the Candelabra" and "Her" studs flashed their handsome smiles to the shutterbugs as they meandered their way inside to catch all the star-studded action.
Hitting the red carpet for a theatrical-filled evening, the stars of "Her" lined up to attend the Los Angeles premiere of the romantic comedy on Thursday (December 12).
Looking dapper, Joaquin Phoenix showed up in dressy-casual attire, posing for some rather serious and intimidating snapshots on the red carpet.
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PHOTO GALLERY: Temple Emanu-El Sisterhood Luncheon
October 19, 2014
The Sisterhood of Temple Emanu-El held a membership luncheon Sunday afternoon.
PHOTO GALLERY: BKYC Lido Beach BBQ
October 19, 2014
Members of the Bird Key Yacht Club made the trip to Ted Sperling Park on South Lido Beach for a beach barbecue on Saturday night.
PHOTO GALLERY: RFS Festivus Games
October 19, 2014
Real Fitness Sarasota hosted the Festivus Games a CrossFit competition on Saturday. The competition was only open to novice and intermediate level athletes.
PHOTO GALLERY: SHS Homecoming Game
October 18, 2014
Fans and alumni of Sarasota High School cheered on the sailors during the Friday night Homecoming game against the North Port Bobcats.
PHOTO GALLERY: Mote Night of Fish, Fun and Fright
October 18, 2014
The Mote Marine Laboratory & Aquarium welcomed trick-or-treaters for a Night of Fish, Fun and Fright on Friday night.
PHOTO GALLERY: Taste of St. Armands
October 17, 2014
More than 15 restaurants on St. Armands Circle offered samplings of their most popular recipes Oct. 17, at the fifth annual Taste of St. Armands. Vendors had the chance to please nearly any palate, with foods ranging from continental cuisine to Italian, Irish, Spanish and Cuban flavors. Proceeds from Taste of St. Armands will benefit All Faiths Food Bank.
PHOTO GALLERY: Cardinal Mooney at ODA
October 17, 2014
The Cardinal Mooney High football team cruised to a 64-0 victory over rival The Out-of-Door Academy in its Class 3A-District 10 opener Oct. 17. With the win, the Cougars earned a berth in the playoffs. Cardinal Mooney will look to defend its district title Oct. 31 versus Bishop Verot.
PHOTO GALLERY: Child Protection Center Pillar of Hope open house
October 16, 2014
The Child Protection Center opened its doors to members of the community Thursday night for the Pillar of Hope Tasting and Awareness open house.
Sarasota Police mourns death of K-9 officer
October 16, 2014
The Sarasota Police Department is mourning the loss of K-9 officer Nero who died on Thursday morning.
Riverview wins PINK match
October 16, 2014
The Riverview High volleyball team defeated rival Sarasota 25-17, 25-20, 20-25, 25-18 in its annual PINK match Oct. 14.
- Nov
29 Light Up Siesta Village and Holiday Parade
5:00 pm - 9:00 pm
- Nov
30 Advent Procession
6:00 pm
- Dec
3 Rachel's Challenge Anti-Bullying Event hosted by The Cal Ripken, Sr. Foundation
6:30 pm - 8:30 pm
- Dec
4 Ringling Holiday Splendor
5:00 pm - 9:00 pm
The gift of music
Riverview High School received a donation of $5,000 during a break in the Kiltie Band Fall concert on Nov. 20.
Coming together for the community
All Faiths Food Bank called on volunteers to help distribute 7,000 Thanksgiving dinners Saturday.
Observer on the hunt for displays
We're making our list of the best holiday lights displays in Sarasota and checking it twice.


text:
The North Face Women's Iodin Jacket
FEATURES of The North Face Women's Iodin Jacket
- Alpine climbing and mountaineering
- Pertex Equilibrium fabric manages moisture-inside and out-with wicking fabric construction and enhanced DWR
- Harness- and pack-friendly alpine handwarmer pockets
- Sleek hem and cuff construction reduces bulk and improves fit
SPECIFICATIONS of The North Face Women's Iodin Jacket
- Average Weight: 13.05 oz / 370 g
- Center Back Length: 25.5"
- 70D x 40D 230 g/m2 TNF Apex Aerobic-74% nylon, 15% polyester
- 11% elastane double weave with DWR
This product can only be shipped within the United States. Please don't hate us.
custy reviews
for the The North Face Women's Iodin Jacket
Average Custy Rating:
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I have this jacket in black and I love it! It looks so sleek and can be worn into any environment. It is lightweight but keeps me warm. Now I can stay warm in the winter months without being hidden under a bulky coat! I plan to keep this jacket in my wardrobe as long as I can and when it gets worn out from too much use, I will definitely buy another one. I would highly recommend this jacket!


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How Will The US Census Bureau API Influence the 2020 Census?
Posted on 06-04-2014
I've been tracking on the API from the US Census Bureau since they launched in 2012, and even met with them to discuss their strategy over the last couple years. The team at the Census Bureau has slowly integrated an external API into their operations, opening up conversations around census survey data, that is harder to achieve from just downloads only.
I recently saw a post that Census Bureau is gearing up for the 2020 census. As I was reading the post, I couldn't help but think about how the Census API will influence how the 2020 census is executed. Additionally I wonder if any other APIs will be used during the census process, such as Twitter or other social platforms.
In my opinion, the census, and its resulting data will continue to be a cornerstone of the API and open data space. Census data adds a lot of value to other websites, mobile apps, and data visualizations and analysis, and is critical in providing context for both our online and offline worlds. I will continue to keep an eye on the US Census API, and look for signs of how APIs are influencing the 2020 census.
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National Briefing | New England: Massachusetts: Tobacco Disclosure Law Revived
Published: October 17, 2001
A federal appeals court reinstated a state law that required tobacco companies to disclose the ingredients in their products. The ruling by United States Court of Appeals for the First Circuit reverses a decision by a federal district judge who said the law was unconstitutional because it would force companies to reveal their trade secrets. The disclosure law was the first of its kind in the nation when it was passed in 1996, but it has never been enforced because of legal challenges.


text: Photo Courtesy of Bill Tetrault Joe Bonamassa Has Grown From Guitarist to Entertainer as He Wows Sioux Falls Again Tuesday Night By Crash April 16, 2014 Joe Bonamassa's 4th Sioux Falls appearance in the past decade was easily his best and shows just how far he has grown as an artist. Read More|Comment Category: Entertainment, Local News Tags: Joe Bonamassa, Washington Pavilion Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text: Meriden Public Library will hold its annual "Food for Fines" month beginning Friday, November 28, 2014 through Wednesday, December 31, 2014. You may "pay" for your overdue fines by contributing one non-perishable food item for each dollar you owe in fines. For example, if you owe $3.00 in overdues, you must bring in 3 items. Food donations do not cover lost or damaged library materials. Bring in those long overdue DVD's cd's, books, etc. and clear up those fines. Borrowers must visit the Circulation Desk in person to take advantage of this opportunity. Please do not donate out-dated food items. All food collected will be delivered to local food pantries. Food items most needed are tuna and other canned meat, dry milk, canned vegetables and fruit, rice, dry and canned beans, canned soups and stews, boxed pasta products, tomato items, juices and cereals. Contact the Meriden Public Library at (203) 238-2344 or (203) 630-6349 if you have questions.