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The SimpliShare element is not a standalone stage of the Connected Traveler Lifecycle. Instead, it is more of a constant that not only provides the fundamental link between the SimpliTravel and SimpliDream elements, but also connects all other elements to each other.
Shared content (if positive) can push new people to start dreaming or help them move to the next stage of their traveler lifecycle. Both airlines and airports must understand this in order to be successful in their engagement strategies. We present below the 10 best engagement initiatives that have actively encouraged social sharing. We hope you enjoy the case-studies. (Note: The Connected Traveler Lifecycle comprises four parts in addition to SimpliShare – you can view case-studies specific to them at SimpliDream, SimpliPlan, SimpliBook and SimpliTravel.)
Marco Serusi
Latest posts by Marco Serusi (see all)
- Ryanair has a Great Brand. What is the Secret to its Success? - October 22, 2014
- [Presentation] Changing Times: The Latest Trends in Airline Marketing - October 14, 2014
- What's Common Between Social Media Content Strategy and TV? Featuring: A Spanish Airline that Really Knows its Stuff - August 20, 2014


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Originally published February 22, 2010 at 8:23 PM | Page modified February 22, 2010 at 9:33 PM
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Top U.S. commander braces for delay in leaving Iraq
The top U.S. commander in Iraq said Monday that the planned withdrawal of all U.S. combat forces by the end of August could be delayed if conditions worsen in the coming months as Iraqis choose a new government.
The Washington Post
Other developmentsElection worker's family killed: An Iraqi campaign volunteer and his family were killed at home Monday. Despite warnings, 47-year-old Hussein Majeed Marioush had been hanging campaign posters for Shiite linked candidates in the volatile mixed-sect district of Zafaraniya, on the outskirts of southern Baghdad. Parliamentary elections are March 7.
Mother and children die: In another Shiite district in Baghdad, a mother and her three children were gunned down.
Bodies dumped: Police found two bodies riddled with bullets dumped in the street of the Sunni neighborhood of Adhamiya.
Green Zone attack: Rocket attacks on the Green Zone injured six people, according to Iraqi officials. An official at the U.S. Embassy said there were no reports of Westerners injured.
Seattle Times news services
WASHINGTON — The top U.S. commander in Iraq said Monday that the planned withdrawal of all U.S. combat forces by the end of August could be delayed if conditions worsen in the coming months as Iraqis choose a new government.
Army Gen. Ray Odierno said his staff had drawn up contingency plans for a delayed withdrawal that he has shared with Pentagon leaders and other U.S. officials during a visit to Washington over the past week. He said he was prepared to make the changes "if we run into problems" but added he was optimistic that would not be necessary.
The United States has about 96,000 troops in Iraq. That's the lowest number of U.S. forces in the country since the U.S.-led invasion that overthrew dictator Saddam Hussein nearly seven years ago.
Under an agreement negotiated under former President George W. Bush, all combat troops are to leave the country by Aug. 31 although some 50,000 will remain behind to help train Iraqi security forces.
The remaining support troops are to be gone by the end of 2011.
"If you ask me today, I'm fully committed and that's the right course of action," Odierno said at the Pentagon.
Shortly after taking office last year, President Obama pledged to pull out all U.S. combat forces from Iraq by the end of August.
At a news conference at the Pentagon, Odierno said he still expected to carry out the original plan but wanted to be prepared if Iraq experiences fresh instability in the aftermath of national elections scheduled for March 7.
"Right now, our plan is to be at 50,000 by the first of September," he said. "And if you ask me today, I'm fully committed and I believe that's the right course of action."
Many Iraqis have said they are worried about a return to widespread sectarian violence as rival factions vie for political control amid the U.S. withdrawal.
Odierno said U.S. forces had not detected a "significant" rise in sectarian violence in recent months, despite anecdotal reports by Iraqis — particularly minority Sunni Muslims — to the contrary. But he allowed that U.S. military officials were concerned about the possibility leading up to the March 7 elections, as well as afterward, when Iraqi politicians are expected to take weeks to haggle over the makeup of a new government.
"If there's a problem in forming the government, does it translate into violence?" Odierno said. "And right now, we're not sure. We think so far it will probably go fairly smoothly, but we'll wait to see."
When asked whether gays should be allowed to serve openly in the military, Odierno said yes, "as long as we are still able to fight our wars."
His comment was among the first to come from a senior military leader now leading troops in battle since the Pentagon announced earlier this month that it would study the issue.
Rebels tighten hold on Libya oil port
Reality leads US to temper its tough talk on Libya
2 Ark. injection wells may be closed amid quakes
Armed guards save Dutch couple from Somali pirates
Navy to release lewd video investigation findings
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- Richard Sherman and cutout Doug Baldwin criticize NFL policies
- Theater of the absurd: Richard Sherman, Doug Baldwin stand up for Marshawn Lynch | Larry Stone
- Sally Clark says she quickly informed city of collision with cyclist
- Seattle-area home prices keep cooling
- In Seattle, a march, 'die-ins' and police pelted with rocks
- Guard reinforcements contain damage in Ferguson
- Parents of Lake Stevens boy shot in mouth had argued about guns in home
- Audit: 2 ex-SHA employees got $130,000 in bogus overtime
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subset: commoncrawl


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- Freeport murder suspect Damon Dixson taken into custody in Rockford
- Local gas station employee arrested for selling liquor to minor
- Renewable Fuel Standard delay 'a mixed blessing,' Bustos says
- Rockford delegation presents inaugural 'Rockford Award' to Norwegian Air
- Education in Illinois making slow progress, according to report
- Illinois GOP Congressional delegation: Obama's immigration plan undermines rule of law
- Suspect, 17, charged in Halloween hit-and-run in Roscoe
- Saint Anthony College of Nursing president to retire
- Man found guilty in deadly August 2013 crash at Mulford and Garrett Lane
- 'The Price is Right Live!' at Coronado March 1; tickets on sale Nov. 21
Rockford Dance Company stages The Emperor and the Nightingale Jan. 29
From press release
Rockford Dance Company (RDC) will present Hans Christian Anderson's beloved fairy tale, The Emperor and the Nightingale, at 2 and 4:30 p.m., Saturday, Jan. 29, at The Sullivan Theater (formerly New American Theater), 118 N. Main St., Rockford.
The Chidren's Dance Theater presentation has been designed for the family. A narration by the composer, portrayed by Jessie Kuntz and written by Connie Kuntz, will delight audiences of all ages. Families will also be assisted in making the connection through a specialized program, which offers a coloring page for the children to learn the characters.
The story opens with the Emperor of China learning that one of the most beautiful things in his empire is the song of the nightingale. When he orders a nightingale brought to him, a kitchen maid leads the court to a nearby forest, where the bird is found. The nightingale agrees to appear at court. The Emperor is so delighted with the bird's song, he keeps the nightingale in captivity. When the Emperor is given a bejeweled mechanical bird, he loses interest in the real nightingale, who returns to the forest.
The mechanical bird breaks down because of overuse. The nightingale learns that the Emperor is deathly ill and returns to the palace. Death is so moved by the nightingale's song that he departs, and the Emperor recovers. The nightingale agrees to sing to the Emperor of all the happenings in the empire, so that he will be known as the wisest Emperor ever to live.
For ticket purchases, contact RDC at (815) 963-3341. Tickets are $9. More information can be found at rockforddancecompany.com.


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Age Suitability All Ages
Ballston Spa Indoor Farmers' Market
Saturday, Feb 9, 2013 9:00a to 12:00p
Candlelight Tour of the Philip Schuyler House Schuylerville, NY
The Ballston Spa Indoor Farmers' Market is held once a month at Cornell Cooperative Extension,50 West High Street in Ballston Spa from 9am-12pm on the following Saturdays: Oct. 6, Nov.3, Dec. 1, Jan. 5, Feb. 9, March 16, April 6, and May 4. Seasonal produce, meat, poultry, baked goods, specialty foods and quality handmade items. Farm related activity area for children provided by The Wonder Room and music by local musicians. For more information- firstname.lastname@example.com or call 885-2772.
Created by BSBPA
Location & Nearby Info
Candlelight Tour of the Philip Schuyler House
Route 4
Schuylerville, NY 12871
(518) 698-3211
Route 4
Schuylerville, NY 12871
(518) 698-3211
Show nearby:
0.7 mi 2 Monument Pizza
0.8 mi 3 Lynns Country Cafe
1.0 mi 4 Randysrestaurant
1.4 mi 5 Dunkin' Donuts
Reviews & Comments
Hot Tickets More »
Wed 8/26 7:30p
Tue 8/11 7:30p
Sat 6/13 9:00a
Sun 1/25 7:00p
Fri 2/6 5:00p
Sun 1/18 7:00p


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Exhibits in El Paso
El Paso Saddleblanket Co.: 6929 Gateway East. Hand-woven rugs ... War Eagles Air Museum: Doña Ana County Airport in Santa Teresa. The museum holds more than 30 aircraft, 40 automobiles and other artifacts from World War II and the Korean War.
Colorado Springs Weekend Events: July 27-29
El Paso County Fair ... Union Blvd., Colorado Springs (downtown). Reserve a free spot to take part in this bonanza of bikes and gear from vintage cruisers to elite track bikes. Visit www.peakregioncyclist.com. 12th Annual Evergreen Cemetery Historical ...
Close UP
On a brisk morning in mid-October, El Paso County Commissioner Dennis Hisey ... will adopt the rules on Tuesday. Meantime, Colorado Springs is sparring with Ultra over 18,000 acres of Banning Lewis Ranch land that it bought out of bankruptcy for $20 ...
Planning For Pikes Peak National Cemetery Continues
It's still on track to open in 2014 despite there not being a final location for the cemetery. "We determined we really needed a national cemetery to serve the veterans of southern Colorado ... in El Paso County by May 2012. While the Kane Ranch off ...
Turkey Track Ranch (in El Paso County), Local Directory ...
Address & Phone Number for Turkey Track Ranch (in El Paso County, Search the Local Directory for the
Turkey Track Ranch | Farm Ranch - farmranch.org
Turkey Track Ranch COMPANY NAME: Turkey Track Ranch. LOCATION ADDRESS. LOCATION STREET: 20989 Stevens Gulch Road ... El Paso County, CO. Elbert County, CO. Fremont ...
Turkey Track Ranch - Colorado - Map and Area Photos
Geocode for Turkey Track Ranch: Latitude: 38.6949965 - Longitude: -104.3727421: Maps and Satellite Views: El Paso County, Hanover NE
Turkey Track Ranch, Colorado, United States
Turkey Track Ranch is a locale located in El Paso county Colorado in the United States of America. It is at 38.6949965 latitude and -104.3727421 longitude. Turkey ...
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Find records of Paola Millan
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Paola A Millan (1972 - 2008) was born on January 29, 1972. She was born into the Millan family.
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Featured video and audio clips on Tony Sparano brought to you by Boston's WEEI Sports Radio.
Grab him now while you still can. Mychal Rivera, Raiders — 34 percent Now we have a legit trend. The switch to head coach Tony Sparano seems to have unlocked Rivera for some reason. He' s now a legit TE1 option in 12-team leagues. Rivera has 36 standard
On Monday afternoon, Patriots head coach Bill Belichick responded to Chris Mortensen's report regarding tension between Tom Brady and the Patriots. Belichick doesn't acknowledge "anonymous sources." He also explained why the team went out of their way to acknowledge The Globe's report regarding Aaron Dobson.
1st-and-10 from the Patriots 18-yard line and didn't attempt a pass against this secondary. Inexplicable stuff from Tony Sparano , really. But let's be very clear about this: Mark Sanchez put the Jets in position to beat the Patriots on Sunday
opportunities in the passing game out of play action. "When it comes to defending Tim Tebow , the Patriots have faced Tony Sparano and the Wildcat before. The only difference is now he will have a guy that can pass the ball. They also had that
in a down year, Belichick still has very little problem coming up with motivational material. Two points: a) Miami coach Tony Sparano is presented as something of a punchline. In the days leading up to the Patriots-Dolphins game in Foxboro, Belichick
poisoning scene in "Bridesmaids" (complete with vomiting and cramping), don't you have to mention once that maybe Tony Sparano didn't have the troops ready to go? -- Kirk, Give me Erin Andrews over Wendi Nix ANY DAY. Are you crazy Minihane
didn't see a lot of teams with multiple players cramping up and guys sucking serious wind in the second quarter . When Tony Sparano gets fired, he has no shot at taking over as the new trainer on "The Biggest Loser.") A terrific game-plan on offense
t even have a coach right now after mercifully canning Dennis Allen on Monday night. The rumor mill is spitting out Tony Sparano 's name as a possible replacement. Yikes. QUARTERBACKS Eli Manning , Giants – 48 percent As I said last week, buy Eli now because
following the 2008 season , DeGuglielmo was hired by Miami coach Tony Sparano after spending the previous five seasons as a member of ..... those bad deals washed out, the Dolphins and head coach Tony Sparano seemed hell-bent on reassembling the Cowboys old offensive
travel to Jersey for an Oct. 20 date with Gang Green. Say goodbye to ... cornerback Darrelle Revis , offensive coordinator Tony Sparano , running back Shonn Greene , quarterback Tim Tebow , tight end Dustin Keller , safety LaRon Landry , defensive linemen
defensive coordinator Rob Ryan , Jets coach Rex Ryan confirmed that two of his assistant coaches (offensive coordinator Tony Sparano and quarterbacks coach Matt Cavanaugh ) would not be retained. The Jets also need to hire a new defensive coordinator to replace
seasons on the Jets staff, and his contract expires in a few weeks. There has been speculation that offensive coordinator Tony Sparano also will not be retained, following his one season with the team. He has two years remaining on his contract. Coach Rex Ryan and owner Woody


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Fort Worth is launching a review of its master thoroughfare plan aimed at accommodating continued suburban growth and central city redevelopment with a greater variety of streets and more efficient traffic flow.
Longtime Fort Worth businessman, philanthropist and preservationist Holt Hickman died Nov. 15, 2014, at the age of 82.
A key linchpin in the Fort Worth economy, American Airlines Group Inc., is considering sites for a new headquarters, possibly outside the city, the airline's CEO said this morning.
Residents of West Fort Worth's Crestwood Association are trying to block the rezoning of a small apartment complex at White Settlement Road and North Bailey Avenue to make way for a planned office building, saying it would represent the start of commercial encroachment into their neighborhood.
Rarely does Golf Digest make the news. Leave it to Dan Jenkins to change that.
SCOTT SONNER, Associated Press
DEE-ANN DURBIN, Associated Press
RENO, Nev. (AP) – Electric car maker Tesla Motors said Thursday that it is preparing a site near Reno, Nevada, as a possible location for its new battery factory, but is still evaluating other sites.
Tesla said it broke ground on the Nevada site in June. It said further that a final decision on the location for the $5 billion factory will be made in the next few months. Tesla has dubbed the proposed facility the "gigafactory," and says it could employ 6,500 people by 2020.
Competition for the factory is intense. California, New Mexico, Arizona and Texas are also in the running. Tesla wants the factory to supply batteries for its Model 3 electric car, which is set to go on sale in 2017.
"Any potentially duplicative investments are minor compared to the revenue that could be lost if the launch of Model 3 were affected by any delays at our primary Gigafactory site," Tesla said in a statement.
The states are trying hard to help Tesla make its decision. Earlier Thursday, Arizona said it had approved a $3 billion permit for Tesla to build the factory in Tucson, even though the company hadn't applied for one.
Three weeks ago, California Gov. Jerry Brown signed legislation that included tax incentives that appeared designed to benefit Tesla. That came two months after Tesla CEO Elon Musk said he considered the state a long shot because of the time it will take to win regulatory approval.
The ground-breaking in Reno doesn't necessarily make Nevada the favorite to land the factory.
On a conference call Thursday following the release of second-quarter earnings, Musk said "at this point the ball is in the court of the governor and the state legislature." He added that Tesla wants incentives that are fair to the state and the company.
Tyler Klimas, press secretary for Gov. Brian Sandoval, told The Associated Press that the governor cannot comment on any incentives Nevada might be discussing with Tesla.
Earlier Thursday, Tesla and its battery supplier, Panasonic Corp., announced that they will collaborate on the battery factory. Tesla will build the facility and Panasonic will make the batteries.
Durbin reported from Detroit.
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19 results for "roy s johnson"
Jordan's legacy still being writtenRoy S. Johnson
We'll always have the video montages -- grainy as they are now in our high-def world -- to remind us of Michael Jordan's greatness. The acrobatics. The big shots (Craig Ehlo and Bryon Russell still have sleepless nights). The moments (like too-sick-t...Blog | March 07, 2012
Michael Jordan's legacy still being writtenRoy S. Johnson
Michael Jordan's status as a player is secure. And his value as a brand icon remains as robust as ever. His legacy? Not so fast.Story | Conversation | March 07, 2012
Absence of NBA games has pro basketball fan Roy S. Johnson antici...Roy S. Johnson
It might not qualify as March Madness in November, but our writer is going to appreciate the college game in the here and now as long as the NBA is dark.Story | Conversation | November 02, 2011
Jerry West and others who share the news of depression help all w...Roy S. Johnson
It's been an especially tragic year in sports, which makes the moves by Jerry West and Pat Summitt to go public with their problems all the more important. Their messages will help.Story | Conversation | October 20, 2011
Serious business when Rafael Nadal, Novak Djokovic and Andy Murra...Roy S. Johnson
Unless tennis does something about the length of the season, the game's top players just might drop their rackets and walk away from the game.Story | Conversation | September 21, 2011
NBA lockout issues make NFL settlement look easy.Roy S. Johnson
All that teeth-gnashing and hand-wringing over the NFL lockout is going to look like child's play by the time the NBA solves its labor issues.Story | Conversation | July 28, 2011
Derrick Rose and Tom Thibodeau won the NBA's most prestigious tro...Roy S. Johnson
The most important part of the NBA season is happening right now: the playoffs. So why has the league already handed out its hardware?Story | Conversation | May 05, 2011
Cleveland Indians are in first place with best record in baseball...Roy S. Johnson
The Indians are in first place and the Royals aren't far behind. (Take that, you big-market teams!) Welcome to the beating heart of baseball.Story | Conversation | April 21, 2011
College basketball: More than ever, the regular season is somethi...Roy S. Johnson
More than ever, the regular season is something to endure until we get to the only games that really matter in college basketball: the NCAA tournament. Our writer might not make it.Story | Conversation | February 09, 2011
Carmelo Anthony, Carson Palmer and other ridiculous trade demands...Roy S. Johnson
I'm sick of Carmelo Anthony and his passive-aggressive demands to leave Denver -- the team that drafted him, the team that built around him.Story | Conversation | January 26, 2011
LeBron James of Miami Heat is finalist to be TIME Magazine's Pers...Roy S. Johnson
Charles Lindbergh in 1927. Nikita Kruschev in 1957. Pope John Paul XXIII in 1962. Why not LeBron James in 2010? Stranger things have happened when Time magazine picks its Person of the Year.Story | Conversation | November 17, 2010
The NBA misses players like Maurice LucasRoy S. Johnson
The NBA misses an intimidating, old-school guy like Maurice Lucas, The Enforcer, the guy whose look was as lethal as any fist.Story | Conversation | November 03, 2010
Ron Washington, Joe Girardi and Dusty Baker, all in the playoffs,...Roy S. Johnson
Ron Washington, Joe Girardi, Dusty Baker ... the Hot Seat Gods would've had them all fired by now. Instead, they're in the postseason. Time to pack the hot seat in ice.Story | Conversation | October 06, 2010
Shaquille O'Neal finds perfect spot to end career: BostonRoy S. Johnson
Shaq's stop in Boston gives him a chance make us forget about his season and a half of disruption in Phoenix and his year of irrelevance in Cleveland.Story | Conversation | August 11, 2010
Terrell Owens, Ken Griffey, Shaquille O'Neal face End Game, Roy. ...Roy S. Johnson
The End Game is a scary, unrelenting beast. Especially to players who have been among the best in their sport. It's the athlete's ultimate reality check, when he (or she) must begin to admit that playing is no longer feasible.Story | Conversation | May 14, 2010
Michael Jordan is about to go to the one place he's really comfor...Roy S. Johnson
There's only one level in Michael Jordan's comfort zone: the top. And he found a way back to it by buying a controlling interest in the Charlotte Bobcats.Story | Conversation | March 03, 2010


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A scrumptious little treasure from the 19th century France, this porcelain box is all hand painted in rich Burgundy with a floral bouquet with gilt enameling. Has the typical brass shell design clasp and hinge. Inside small floral painting on white glazed porcelain.
This fine miniature box is in excellent antique condition, the sides are curved and the top lid rounded, doll size it measures approximately 2.5" across, high 1.25, the bottom 2.5".
Fabulous quality made of heavy porcelain by Porcelain de Paris, world renounced for making exceptional quality porcelains that originated in 1773, it is signed on the bottom with the crossed arrows painted under glaze in blue on the bottom exterior of the box and also Made in France.
Item ID: 107
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Jan 13, 2014 at 5:27 am
ST. CLOUD, Minn. (KNSI) The National Weather Service has issued a Winter Weather Advisory for central Minnesota, including the St. Cloud area, from 6 pm Monday through 3 pm Tuesday.
A clipper system will bring snowfall accumulations from 2 to 4 inches to parts of central and southern Minnesota and west-central Wisconsin Monday night into early Tuesday, with blowing snow persisting into Tuesday afternoon.
The Winter Weather Advisory has been issued for areas generally along and south of Interstate 94.
National Weather Service forecaster Jacob Beitlich says snow will begin accumulating by early Monday night and persist into Tuesday morning.
Northwest winds will increase to between 25 and 35 miles per hour with gusts to 40 miles per hour after midnight, and persist through the day Tuesday.
The main impacts from this clipper system will be blowing and drifting snow with signficantly reduced visibilities.
News Director
Temp: 7°F (-14°C)
Dewpoint: -4
Wind: 6 S
Weather: Clear
Mon December 1, 2014
Fri December 5, 2014
Sat December 27, 2014
Sat December 27, 2014
Wed December 31, 2014


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The Top 10 In Action Sports
01This British Council Is Trying To Make Skateboarding A Crime...
02Want To Escape The UK And Surf Every Day? This Is The Place To Go…
03Snowfall In New York Has Been So Deep, People Can't Get Out Of Their Houses
04What Do You Get If You Cross A Zip-Wire With A Roller Coaster?
0523 #FirstWorldProblems People Encounter When Skiing
067 Awkward Moments Every Brit Experiences When Surfing Abroad
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09This 22 Year Old Student Took Three Years To Make This Adventure Film. The Result Is Truly Beautiful…
10From Small Photo To Breathtaking Reality: This Ski Trip Is One Of The Best We've Seen...
Fanatic Quad TE 2014
A Windsurfing video by fanaticinternational - 1,063 views
Under the lip. Down the line. If you're a wave-riding purist, the Quad is your Waveboard. Fanatic shaper Sebastian Wenzel is explaining the shape details here together with Klaas Voget and Victor Fernandez. A clip by Carl Nyberg Productions.
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The Fed will issue in the first quarter of next year new rules for financial holding companies in the physical commodities markets.» Read More
The FDA approved the first screening test for colon cancer that uses patients' DNA to help spot potentially deadly tumors and growths.
Apple and Samsung's market share is set to decline and not even the iPhone 6 or wearable tech can stop the slide, Fitch said.
Pastry chef Waylynn Lucas is pushing the boundaries of circular sweets with her bakery, Fonuts, which specializes in faux doughnuts.
Banking industry profits are soaring to near record levels, boosted by the fastest increase in lending since Great Recession, The Wall Street Journal reports.
A metasearch travel website is expanding its audience with an offbeat ad campaign, Skift reports.
Hate waiting to pay the restaurant check? A slew of businesses is here to help.
Bill Gross of Pacific Investment Management, slightly reduced his holdings of U.S. Treasuries and government-related debt in July.
The 3-D market is projected to reach $175 billion by 2020. Startups are crowdfunding some wild ideas, including 3-D pens and earbuds.
Forget your toothpaste? Need more towels? If you're staying at Starwood Hotels, you may be served by a Botlr.
A California bill that would require cellphone makers to install a "kill switch" to render stolen devices inoperable has passed the state legislature.
Of the 500 stocks in the benchmark large-cap S&P index, around 176 of them have fallen by at least 10 percent from their recent highs.
The Fed Chair has made a career of predicting interest rates, but as for stock calls—her newest vocation—she's off to an uncertain start.
Investors are more protected against a fall in stocks than at any other point since October 2008 amid Fed worries and geopolitical fears.
While geopolitical uncertainty continues, investors should be keeping an eye on Libya, Dennis Gartman says.
Payday lending just got one more high-profile opponent.
Here are some things consumers can do to try to ensure their problems are heard by their banks.
President Barack Obama pledged to support Iraqi President Fouad Massoum and newly nominated prime minister-designate Haider Abadi.
Two investment firms said they would buy half of the portfolio companies held by JPMorgan Chase & Co's private equity business, One Equity Partners.
A ruling in the Ed O'Bannon case and a move by the NCAA itself have paved the way for big changes in college athletics and amateurism.
Revel's auction had already been postponed one week to allow for more time to review bids, court filings indicated.
Suze Orman offers four money-saving holiday shopping tips for a better holiday season possible. Don't spend more than you want to, warns Suze.
DeVante returns to update Suze on the changes he's made since first appearing on the show in 2012 asking for help in curbing his spending and designer clothes addiction.
Shelley from New York wants to know whether to drop her whole life insurance even if it means she'll lose money.


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Review Summary
Belk Silverworks Cultured Pearl Necklace
$20.00 Original Price $50.00
Savings: $30.00 (60%)
- 18-in. L
- Jump ring closure
- Polished finish
- Sterling silver
- Imported
Shipping your purchase is easy on belk.com. Depending on the destination of your package, you can expect it to arrive within 4-7 business days. Shipping Information
Returns are easy on belk.com. Easy returns


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Now Playing
November 12th, 2014:
|Morgan Brittany, a tough cookie just like Scarlett O'Hara who she's played many times, has launched PolitiChicks.com with her friends Ann-Marie Murrell and Dr. Gina Loudon, a website with an unashamedly conservative viewpoint. [more]
November 5th, 2014:
|In the documentary Who is Norman Lloyd?, the late Karl Malden said: "If you don't know Norman Lloyd, you should know Norman Lloyd, because Norman Lloyd is the history of our industry." [more]
October 29th, 2014:
|"This special edition of Triad Today featured Governor Pat McCrory, who has been a frequent guest of the show. On this visit, we focused much of our discussion on his first two years as our Chief Executive." [more]
November 15th / 16th:
Healthcare Special:
- Richard Maas talks about holiday depression
- Jennifer Bailiff discusses link between nutrition and good health
- Dr. Tamika Howell gives tips on avoiding winter viruses
- Dr. Bret Borchelt promotes heart health for colder months
November 22nd / 23rd:
Encore presentation of Report on the State of Public Instruction
Special guest: State Superintendent of Public Instruction Dr. June Atkinson
November 29th / 30th:
Encore presentation of October's conversation with NC Governor Pat McCrory


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text: The fundamental problem with the study is that they extrapolate screening into treatment. Screening in and of itself provides information to doctors and patients; there is virtually no risk to the screening process. Once screened, the decision for biopsy, and ultimate treatment is between physician and patient, and needs to be customized for every circumstance.


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Search Result
Search Tags: giving back
Best practices for living a healthy financial life: Giving back
Perhaps it's because the simple act of helping others amplifies a greater purpose in all of us.
Tuesday - 11/25/2014, 10:35am EST
Tags: Barry Glassman, Finances, charity, Giving backListen
Va. 4th grader fights brain tumor with wishes, selflessness
A determined Loudoun County girl, recently diagnosed with an inoperable tumor on her brain stem, is leading an effort to help other children facing life-threatening illnesses.
Friday - 12/07/2012, 04:12pm EST
Tags: Make-A-Wish Foundation, brain tumors, Health, Giving back, Neal AugensteinListen
, November 27, 2014
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Weekly Reading List
Engineering Serendipity: On how creativity is sparked by your networks, and face-to-face communication.
Distributed Systems and the End of the API: Chas Emerick discusses issues with distributed systems and how to solve them.
The Story of the Hearing Glove: When Norbert Wiener presented a device that could translate sound to touch, people couldn't wait to try it out. Testing didn't go as planned.
Juking The Stats
If you're a fan of the HBO show The Wire[1], "juking the stats" would be a familiar concept. In the show, Baltimore city cops – under pressure from management to improve crime numbers – resort to short term tactics that get better numbers but don't necessarily reduce crime. Reclassifying crimes to lower categories, increasing the arrest rate by arresting for minor offenses, under reporting crimes are all part of the play book. And as Pryzbylewski – a former cop who becomes a teacher – later finds out, the same story repeats itself in the city schools. Under pressure from the state, to improve standardized test scores teachers focus on teaching for the tests rather than actually educating their students.
Juking the stats is however, not just a great sound bite on a TV show. It is an all too real issue that plagues organizations – public and private sector alike[2][3]. Performance measurements introduce perverse incentives and it is human nature, when measured, to optimize for the metric against which they are being judged[4].
The world of software engineering is no stranger to this problem. Software engineering and its management is a complex beast and relative to other engineering disciplines is still in its infancy. We are still figuring out effective ways to track and measure performance. Most methods are far from perfect and suffer from unintended consequences.
In some agile organizations – especially those that are new to agile – measuring team performance by their sprint velocity has become common practice. Far too often, this leads to teams – under pressure to deliver the committed story points in that sprint – unintentionally cutting corners on critical aspects like quality and testing only to pay the price later[5].
Large engineering programs require teams to report status on a weekly basis, typically as red, yellow or green or some variation thereof. The stigma attached with reporting one's status as red can lead to teams suppressing problems. Being honest about these issues ahead of time could have fixed those issues, but the pressure[6] to not report red, means these issues remain buried until it's too late.
In less mature organizations, QA teams are sometimes incentivized by the number and priority of bugs that they open. This invariably leads to bug priority inflation and battles with the development teams. Low team morale is an inevitable side effect.
Then, there is the possibly apocryphal tale of IBM incentivizing programmers by lines of code only to result in programmers intentionally writing verbose code.
In all of these cases, you see teams when pressured by poorly designed incentives and metrics, lose sight of the long term goals and focus on the short term statistics – sometimes overtly, but usually inadvertently. Qualitative attributes like software quality, good design and resilience end up taking a back seat. Measuring and tracking performance is a good thing and is essential for continuous improvement. However, it's just as important to be aware of the possibility that more often than not, unintended consequences may rear its ugly head. When it does, it is imperative that leaders react and be prepared to either fix the metric or dump them entirely.
"Don't matter how many times you get burnt, you just keep doin' the same." – Bodie[7]
- If you're not, you should be. Apart from having a great storyline and an excellent cast of characters, it is rich with lessons in economics, management and human behavior. ↩
- Crime Report Manipulation Is Common Among New York Police, Study Finds – NYT ↩
- Criticism for standardized testing as a measure for driving school funding as collected by Wikipedia ↩
- There are a number of examples of the unintended consequences of perverse incentives at play. One of the more interesting examples from Bill Bryson's A Short History of Everything is the story of paleontologists paying the locals for each fossil fragment they turn in. The paleontologists later find that the locals were smashing larger bone fragments into smaller pieces to maximize gain and in the process rendering the fossils worthless. The authors of Freakonomics collect a few more examples in this NYT article. ↩
- Joshua Kerievsky makes an interesting case for doing away with story points. ↩
- albeit imagined ↩
- Epigraph from "Time after Time", season 3, episode 1 of The Wire ↩
Weekly Reading List
How Complex Systems Fail: A great, but short paper by Dr. Richard Cook, about how complex systems fail, drawn from his experience in health care. Bonus: Dr. Cook's presentation at Velocity Conf.
The Trouble With Harvard: The Ivy League is broken and only standardized tests can fix it
I'm Chevy Chase and You're Not: An excerpt from Saturday Night: A Backstage History of Saturday Night Live
Dear Novak, Love Roger: Novak Djokovic and Roger Federer exchange emails during the US Open Final – another masterpiece by Brian Phillips.
Why You Should Refrigerate Tomatoes and Ignore Anyone Who Says Otherwise: Serious Eats at it again, challenging conventional culinary wisdom with experimentation and data.
Lawrence in Arabia
I recently read Lawrence in Arabia: War, Deceit, Imperial Folly and the Making of the Modern Middle East – Scott Anderson's history of the Middle East circa World War I with T. E. Lawrence as the central character. While the book revolves around Lawrence, Anderson also introduces a coterie of peripheral characters who were just as influential in shaping the history of the time.
Unlike what you might expect from a book on history, the book maintains a breezy pace and is a page turner. Anderson also presents a balanced appraisal of the characters involved – Lawrence in particular, which given his legendary status couldn't have been easy. What makes the book particularly engrossing and relevant is how consequential those events that occurred nearly a hundred years ago were – you could draw a direct correlation between the events described in the book to the state of the Middle East and may be even the world today. A must read for a history buff and highly recommended even otherwise.
Federer is back… may be
Great to see Federer back in top form against Del Potro. Not all of it was pretty, but there were moments where the Federer of old shone through. Next up Nadal. My prediction: they split the first two sets and Nadal runs away with the third, though I'll be rooting for Federer all the way.
Powershares Series Champions Cup
Powershares Series Champions Cup, a set on Flickr.
US Open 2012
US Open 2012, a set on Flickr.
Crime TV
While I'm on a constant quest to cut down on how much TV I watch, I have added a couple more shows to my Netflix Instant queue. I have always loved good crime television. I tried getting my fix with the various Law and Order's for a while and I hate to admit that I even watched CSI:Miami for a couple of seasons. But those shows never really did it for me.
What I miss the most is the classic whodunit. Agatha Christie's Poirot – the David Suchet version – was an all time favourite (season 1 is now on Netflix Instant). I recently came across Inspector Lewis imdb netflix on PBS' Masterpiece Mystery and it is quickly becoming one of my top shows. I'm not quite sure if I think it betters Poirot, but it is close. The setting is the university city of Oxford where Lewis and his partner Hathaway solve a murder or two – usually two – every episode. The dynamic between the down to earth Lewis and the university educated Hathaway, the unique cast of suspects and victims plucked from the world of academia and clergy are what keeps the show going. I also can't help but feel that Oxford adds a touch of class to what is otherwise the gory world of crime.
The other show is Intelligence imdb netflix based in Vancouver. I like to think of it as the Canadian Wire, though it's not as nuanced as The Wire. Also unlike the Wire, it has surprisingly little violence. Intelligence is instead about the battle for information between law enforcement and organized crime. Like most modern crime shows, there are no heroes or villains – the good are not all good and the bad are not all bad. Not only are the cops and the criminals fighting each other using a network of informants and moles, they are also fighting amongst each other. This constant struggle more than makes up for the lack of violence.
These are two great crime shows with very different characteristics. While Inspector Lewis enjoys patronage by PBS in the US, it's a pity that Intelligence hasn't been broadcast in the US. It's a show that might have done very well on HBO or Showtime. Well, at least they're both on Netflix Instant.
Podcasts And Happiness
According to the calculations of Frey and Stutzer[1], a person with a one-hour commute has to earn 40 percent more money to be as satisfied with life as someone who walks to the office. Another study[2], led by Daniel Kahneman and the economist Alan Krueger, surveyed nine hundred working women in Texas and found that commuting was, by far, the least pleasurable part of their day.
That should have made me downright miserable, considering that my new job has increased my commute by about 4000%. I went from walking across my street to driving about 40 minutes each way, in gnarly LA traffic no less.
Luckily, I've discovered podcasts – albeit a decade too late – to keep me sane. I've mostly stuck to Martin Fowler's recommendations with the addition of Freakonomics radio. By far the most consistently interesting podcast I've come across is RadioLab. The episode Detective Stories with three stories around digging up the past is particularly captivating.
While I believe that podcasts have ensured that my happiness has not dropped or may even have increased, they've brought problems of their own. There are times when I realize that I'll be reaching my destination before the end of an episode, resulting in me quixotically willing the traffic lights to turn red and hoping that my commute was a wee bit longer. File that one under first world problems.
I've tentatively settled on Google's Listen app as my podcast delivery vehicle of choice on Android. It's buggy and not supported any more by Google, but it syncs with my Google Reader account. I would happily pay for the BeyondPod app if I could figure out how to sync a specific folder within Google Reader.
Sidebar: While searching for the study linking happiness to commute lengths, the first result was Jonah Lehrer's post (linked above). Turns out that Jonah is also the contributor to RadioLab and contributed to my other favorite episode which randomly enough happens to about the pervasiveness of randomness in our lives.
[1] Stress That Doesn't Pay: The Commuting Paradox by Stutzer and Frey
[2] Developments in the Measurement of Subjective Well-Being by Kahneman and Krueger


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Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease.
ABSTRACT An inversion polymorphism of approximately 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene defines two haplotype clades, H1 and H2. Several small case-control studies have observed a marginally significant excess of the H1/H1 diplotype among patients with Parkinson's disease (PD), and one reported refining the association to a region spanning exons 1 to 4 of MAPT. We sought to replicate these findings.
We genotyped 1,762 PD patients and 2,010 control subjects for a single nucleotide polymorphism (SNP) that differentiates the H1 and H2 clades. We also analyzed four SNPs that define subhaplotypes within H1 previously reported to associate with PD or other neurodegenerative disorders.
After adjusting for age, sex, and site, we observed a robust association between the H1/H1 diplotype and PD risk (odds ratio for H1/H1 vs H1/H2 and H2/H2, 1.46; 95% confidence interval, 1.25-1.69; p = 8 x 10(-7)). The effect was evident in both familial and sporadic subgroups, men and women, and early- and late-onset disease. Within H1/H1 individuals, there was no significant difference between cases and control subjects in the overall frequency distribution of H1 subhaplotypes.
Our data provide strong evidence that the H1 clade, which contains MAPT and several other genes, is a risk factor for PD. However, attributing this finding to variants within a specific region of MAPT is premature. Thorough fine-mapping of the H1 clade in large numbers of individuals is now needed to identify the underlying functional variant(s) that alter susceptibility for PD.
- SourceAvailable from: Gautami Das
Article: Microtubule-associated protein tau (MAPT) influences the risk of Parkinson's disease among Indians.[Show abstract] [Hide abstract]
ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disease of the central nervous system and its prevalence increases with age. Microtubule-associated protein tau (MAPT), a neuronal protein is involved in the pathogenesis of several neurodegenerative diseases including PD. To determine the broader significance of this association with PD, replicative studies in distinct ethnic populations are required. In this study, we investigated MAPT for its potential association with PD using five haplotype-tagging SNPs and the del-In9 polymorphism of MAPT in 301 PD patients and 243 healthy controls from eastern India. Our case-control analysis did not show a significant association with any of the markers and PD. However, a risk haplotype [GAC+G] for PD was identified (OR=1.563; 95% CI=1.045-2.337; p=0.03). In addition, haplotype AAC+A (OR=2.787; 95% CI=1.372-5.655; p=0.004) was strongly associated with early onset PD (age at onset < or =40 years) and AAC+G haplotype showed a weak association (OR=2.233; 95% CI=1.018-4.895; p=0.045) with late onset PD (age at onset >40 years). This observation highlights the significance of rs7521 in modifying the age at onset of PD under a common haplotype background. We also identified AGC+A as a risk haplotype for sporadic cases (OR=2.773, 95% CI=1.198-6.407, p=0.016). This is the first association study from India conducted on MAPT among PD patients and provides valuable information for comparison with other ethnic groups.Neuroscience Letters 06/2009; 460(1):16-20. · 2.03 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous tauopathies, including Alzheimer's disease. The molecular diversity of Tau is very useful when analyzing it in the brain or in the peripheral fluids. Immunohistochemical and biochemical characterization of Tau aggregates in the brain allows the postmortem classification and differential diagnosis of tauopathies. As peripheral biomarkers of Alzheimer's disease in the cerebrospinal fluid, Tau proteins are now validated for diagnosis and predictive purposes. For the future, the detailed characterization of Tau in the brain and in peripheral fluids will lead to novel promising biomarkers for differential diagnosis of dementia and monitoring of therapeutics.Biomarkers in Medicine 08/2008; 2(4):363-84. · 3.22 Impact Factor
Article: YY1 binds to α-synuclein 3'-flanking region SNP and stimulates antisense noncoding RNA expression.[Show abstract] [Hide abstract]
ABSTRACT: α-synuclein (SNCA) is an established susceptibility gene for Parkinson's disease (PD), one of the most common human neurodegenerative disorders. Increased SNCA is considered to lead to PD and dementia with Lewy bodies. Four single-nucleotide polymorphisms (SNPs) in SNCA 3' region were prominently associated with PD among different ethnic groups. To examine how these SNPs influence disease susceptibility, we analyzed their potential effects on SNCA gene expression. We found that rs356219 showed allele-specific features. Gel shift assay using nuclear extracts from SH-SY5Y cells showed binding of one or more proteins to the protective allele, rs356219-A. We purified the rs356219-A-protein complex with DNA affinity beads and identified a bound protein using mass spectrometry. This protein, YY1 (Yin Yang 1), is an ubiquitous transcription factor with multiple functions. We next investigated SNCA expression change in SH-SY5Y cells by YY1 transfection. We also analyzed the expression of antisense noncoding RNA (ncRNA) RP11-115D19.1 in SNCA 3'-flanking region, because rs356219 is located in intron of RP11-115D19.1. Little change was observed in SNCA expression levels; however, RP11-115D19.1 expression was prominently stimulated by YY1. In autopsied cortices, positive correlation was observed among RP11-115D19.1, SNCA and YY1 expression levels, suggesting their functional interactions in vivo. Knockdown of RP11-115D19.1 increased SNCA expression significantly in SH-SY5Y cells, suggesting its repressive effect on SNCA expression. Our findings of the protective allele-specific YY1 and antisense ncRNA raised a novel possible mechanism to regulate SNCA expression.Journal of Human Genetics advance online publication, 12 September 2013; doi:10.1038/jhg.2013.90.Journal of Human Genetics 09/2013; · 2.37 Impact Factor
Page 1
Association Analysis of MAPT H1 Haplotype and Subhaplotypes
in Parkinson's Disease
Cyrus P. Zabetian, MD, MS1,2, Carolyn M. Hutter, MS3, Stewart A. Factor, DO4, John G. Nutt,
MD5, Donald S. Higgins, MD6, Alida Griffith, MD7, John W. Roberts, MD8, Berta C. Leis, RN,
PhD7, Denise M. Kay, PhD9, Dora Yearout, BS1,2, Jennifer S. Montimurro, BS9, Karen L.
Edwards, PhD3, Ali Samii, MD2,10, and Haydeh Payami, PhD9
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care
System, Seattle, WA
2Department of Neurology, University of Washington School of Medicine, Seattle, WA
3Department of Epidemiology, University of Washington School of Public Health and Community
Medicine, Seattle, WA
4Department of Neurology, Emory University School of Medicine, Atlanta, GA
5Department of Neurology, Oregon Health and Science University, Portland, OR
6Parkinson's Disease and Movement Disorder Clinic, Albany Medical Center, Albany, NY
7Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center, Kirkland, WA
8Virginia Mason Medical Center, Seattle, WA
9Genomics Institute, Wadsworth Center, New York State Department of Health, Albany, NY
10Parkinson's Disease Research Education and Clinical Center, Veterans Affairs Puget Sound
Health Care System, Seattle, WA.
Objective—An inversion polymorphism of approximately 900kb on chromosome 17q21, which
includes the microtubule-associated protein tau (MAPT) gene defines two haplotype clades, H1 and
H2. Several small case–control studies have observed a marginally significant excess of the H1/H1
diplotype among patients with Parkinson's disease (PD), and one reported refining the association
to a region spanning exons 1 to 4 of MAPT. We sought to replicate these findings.
Methods—We genotyped 1,762 PD patients and 2,010 control subjects for a single nucleotide
polymorphism (SNP) that differentiates the H1 and H2 clades. We also analyzed four SNPs that
define subhaplotypes within H1 previously reported to associate with PD or other neurodegenerative
Results—After adjusting for age, sex, and site, we observed a robust association between the H1/
H1 diplotype and PD risk (odds ratio for H1/H1 vs H1/H2 and H2/H2, 1.46; 95% confidence interval,
1.25–1.69; p = 8 × 10−7). The effect was evident in both familial and sporadic subgroups, men and
women, and early- and late-onset disease. Within H1/H1 individuals, there was no significant
Address correspondence to Dr Zabetian, Geriatric Research Education and Clinical Center S-182, VA Puget Sound Health Care System,
1660 South Columbian Way, Seattle, WA 98108. firstname.lastname@example.com.
This article includes supplementary materials available via the Internet at
NIH Public Access
Author Manuscript
Ann Neurol. Author manuscript; available in PMC 2010 March 11.
Published in final edited form as:
Ann Neurol. 2007 August ; 62(2): 137–144. doi:10.1002/ana.21157.
NIH-PA Author Manuscript
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difference between cases and control subjects in the overall frequency distribution of H1
Interpretation—Our data provide strong evidence that the H1 clade, which contains MAPT and
several other genes, is a risk factor for PD. However, attributing this finding to variants within a
specific region of MAPT is premature. Thorough fine-mapping of the H1 clade in large numbers of
individuals is now needed to identify the underlying functional variant(s) that alter susceptibility for
The microtubule-associated protein tau, encoded by the MAPT gene, is primarily expressed in
neurons and plays a key role in the organization and integrity of the cytoskeleton.1,2
Filamentous neuronal tau inclusions define a set of neurodegenerative diseases collectively
known as the tauopathies, which include Alzheimer's disease (AD), progressive supranuclear
palsy (PSP), corticobasal degeneration (CBD), and frontotemporal dementia with
parkinsonism linked to chromosome 17.1,2 MAPT sequence variation was first linked to the
etiopathogenesis of tauopathies by the discovery of mutations resulting in frontotemporal
dementia with parkinsonism linked to chromosome 17, and subsequently an extended common
haplotype (H1) across the gene was shown to associate with disease risk in PSP and CBD.3–
Though Parkinson's disease (PD) shares some clinical features with the tauopathies, it has been
assigned to a distinct subset of neurodegenerative diseases (the α-synucleinopathies) by
histopathology because it is characterized by intraneuronal accumulation of α-synuclein, rather
than tau.8 Thus, initial reports that the MAPT H1 haplotype was also associated with PD were
intriguing but met with some skepticism. Since then the association between MAPT variants
and PD has remained tenuous with a number of small case–control studies reporting either a
marginal or no significant overrepresentation of the H1/H1 diplotype among cases (Table 1).
9–23However, a recent meta-analysis of 10 such studies in white subjects supported the
hypothesis that the H1 haplotype might confer susceptibility for PD (pooled odds ratio [OR]
for H1/H1 vs H1/H2 and H2/H2, 1.49; confidence interval [CI], 1.28 –1.74).24
The H1 and H2 haplotypes actually represent two distinct clades or families of subhaplotypes
that arose from an inversion of 900kb on chromosome 17q21 approximately 3 million years
ago.25 Since the event, the two inverted regions, which contain MAPT and several other genes,
have been recombinationally suppressed and have accumulated sequence variation
independently. As a result, any one of a large number of single nucleotide polymorphisms
(SNPs) can be genotyped to differentiate the two haplotype clades (referred to hereafter as H1–
H2 SNPs). However, because these SNPs are in perfect linkage disequilibrium (LD) with one
another (r2 =1) across the entire region, the association of a given H1–H2 SNP with disease
risk could be due to functional variation within any segment of MAPT or a neighboring gene.
To more precisely map the disease-associated region in PD, Skipper and colleagues27 analyzed
14 SNPs specific to the H1 clade (ie, SNPs that were polymorphic on H1 chromosomes but
monomorphic on H2 chromosomes) in subjects of the H1/H1 diplotype. A subhaplotype
composed of two such "H1-SNPs" (rs242562 and rs2435207) spanning MAPT exons 1 to 4
was significantly overrepresented in cases versus control subjects refining the PD-associated
interval from approximately 900 to 90kb. More comprehensive analyses of H1-SNPs have
subsequently identified disease-associated H1 subhaplotypes overlapping the same MAPT
region in PSP, CBD, and AD.28–30 In this study, we sought to confirm whether the H1 clade
is associated with PD, and if so, whether the effect can be attributed to specific H1-SNPs or
subhaplotypes previously implicated in PD and the tauopathies.
Zabetian et al.Page 2
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Subjects and Methods
We recruited 1,762 PD patients (mean age at onset [AAO], 58.7 ± 11.6 years; range, 24–93
years; mean age at enrollment, 68.0 ± 10.6 years; male sex, 67.7%) and 2,010 control subjects
(mean age at enrollment, 67.4 ± 18.3 years; male sex, 37.3%) through the NeuroGenetics
Research Consortium, which includes movement disorder clinics in Albany, New York,
Atlanta, Georgia, Portland, Oregon, and Seattle, Washington. All patients met UK PD Society
Brain Bank clinical diagnostic criteria31 for PD as determined by a movement disorder
specialist and were consecutively recruited except that patients who had an AAO less than 20
years, whose race was not solely classified as "white" (by self-report), or who carried
pathogenic mutations in LRRK2 or PARK2 (homozygotes/compound heterozygotes) were
excluded from the study population. Patients with an AAO ≤ 50 years were defined as early-
onset PD and comprised 25.4% of all cases. Among patients, 22.9% reported a family history
of PD in at least one first- or second-degree relative and were classified as "familial" PD for
this analysis. In such instances, only one affected individual from each family was included in
the study.
Control subjects had no history of parkinsonism and were either spouses of PD patients (31.2%)
or healthy volunteers from the local community (68.8%). The institutional review boards at
each participating site approved the study, and all subjects gave informed consent.
Marker Selection and Genotyping
Our primary objective was to select MAPT variants previously reported to modify PD
susceptibility. To do this, we chose a single H1–H2 SNP (rs1800547) to differentiate the H1
and H2 haplotype clades,3,14,25 and three H1-SNPs (rs242562, rs3785883, and rs2435207)
that defined the two and three locus H1 subhaplotypes that Skipper and colleagues27 observed
to associate with PD.
We sought additional MAPT variants for analysis based on published data from case–control
studies on tauopathies. Three H1-SNPs (rs242557, rs3785883, and rs2471738), either
individually or together as a three-locus subhaplotype, have been shown to associate with
disease risk in PSP, CBD, and AD.28–30 One of these (rs3785883) was already selected for
analysis. To avoid unnecessary genotyping, we assessed LD between the remaining two SNPs
(rs242557 and rs2471738) and the three PD-associated H1-SNPs described earlier using data
on 60 unrelated individuals of European ancestry from the International HapMap Project CEU
population (http://www.hapmap.org).32 We used the LD-select algorithm33 as implemented
on the SeattleSNPs Genome Variation Server (http://gvs.gs.washington.edu/GVS/) to estimate
LD (measured as r2) among these markers. Of the two nonoverlapping tauopathy-linked SNPs,
one (rs242557) was discarded because it was highly correlated with rs242562 (r2 = 0.96). The
other (rs2471738) was selected for analysis because it was imperfectly correlated to all SNPs
in the group (r2 = 0.03– 0.71).
Genotyping was performed by TaqMan assay using an ABI 7900HT Sequence Detection
System (Applied Biosystems, Foster City, CA). To assess accuracy, we also genotyped each
SNP by resequencing in 94 DNA samples.
Data Analysis
We assessed each SNP for Hardy–Weinberg equilibrium in cases and control subjects using
an exact test. For all markers, we first tested for association between allele frequencies and PD
using a Pearson's χ2 test. We examined the H1–H2 SNP using a recessive model (H1/H1 vs
H1/H2 and H2/H2). For H1-SNPs, we examined the association between genotype and PD
Zabetian et al.Page 3
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using logistic regression, with homozygotes for the more common allele as the reference. Tests
of H1-SNPs were restricted to H1/H1 individuals. To account for differences in important
variables between cases and control subjects, we then used logistic regression to test for
genotypic associations, adjusting for sex, site, and age at enrollment (by three age strata: <50,
50–80, and >80 years). The Breslow–Day test was used to test the homogeneity of the ORs for
the H1–H2 SNP across sites. We assessed the effect of the H1–H2 SNP on AAO by comparing
the mean AAO in the H1/H1 versus the combined H1/H2 and H2/H2 groups by Student's t
test. These analyses were performed using STATA version 8.
We used HAPSTAT34 to reconstruct H1 subhaplotypes from unphased genotype data and to
test subhaplotype–disease associations without adjustment and after adjustment for sex, site,
and age. We excluded subhaplotypes with an estimated frequency of <0.01 in cases and control
subjects. For a given set of H1-SNPs, we first performed a global likelihood ratio test to assess
whether the overall subhaplotype frequency distribution differed between cases and control
subjects. In instances in which the overall distribution significantly differed or where the effects
of a specific subhaplotype had been reported in the literature, we then examined the effects of
each individual subhaplotype compared with all others. We used coefficient estimates and
standard errors given by the program to construct ORs and 95% CIs. We calculated pairwise
LD (measured as D′) between H1-SNPs in cases and control subjects, and created graphic
representations of the data using Haploview.35
There were no discordant calls between genotypes determined by TaqMan assay or
resequencing. No significant deviation from Hardy–Weinberg equilibrium was observed for
any of the SNPs except rs2471738, for which a marginally significant deviation was seen in
cases ( p = 0.02) but not control subjects ( p = 0.27).
We observed a significantly greater frequency of the H1 haplotype in cases compared with
control subjects (81.8 vs 77.4%; χ2 = 22.6; OR, 1.31; 95% CI, 1.17– 1.47; p = 2 × 10−6). The
H1/H1 diplotype was strongly associated with PD and remained so after adjustment for age,
sex, and site (Table 2; OR, 1.46; 95% CI, 1.25–1.69; p = 8 × 10−7). The effect was seen in both
familial and sporadic subgroups, in early-and late-onset disease, and in both sexes (Table 2
and Table 3). The ORs for the H1/H1 diplotype were not significantly different across sites
(χ2 = 3.95; p = 0.27), and the direction of the effect was the same at each site (Georgia: OR,
1.39; 95% CI, 0.79 –2.46; New York: OR, 1.76; 95% CI, 1.27–2.44; Oregon: OR, 1.24; 95%
CI, 1.01–1.53; Washington: OR, 1.58; 95% CI, 1.25–2.01). We did not observe a significant
effect of the H1/H1 diplotype on AAO (mean AAO H1/H1, 58.4 ± 11.7 years; H1/H2 and H2/
H2, 59.3 ± 11.5 years; p = 0.10).
To determine whether the observed effects on PD risk were attributable to variation within the
H1 clade, we then examined four H1-SNPs in all subjects of the H1/H1 diplotype (n = 1,187
cases and 1,191 control subjects). These four markers spanned a distance of approximately
49kb across MAPT (Fig), and only two (rs2435207 and rs2471738) of the four were in strong
LD with one another (cases: D′ = 0.98; control subjects: D′ = 0.97; see Fig). The pattern of LD
among H1-SNPs was similar in cases versus control subjects (see Fig).
To test the relation between H1-SNPs and PD risk, we first assessed each marker individually
and found no significant difference in genotype frequencies between cases and control subjects
after Bonferroni correction for multiple testing ( p corrected > 0.07, data not shown). We then
reconstructed H1 subhaplotypes and tested for association with PD using the full marker set
or subsets of SNPs.
Zabetian et al.Page 4
Ann Neurol. Author manuscript; available in PMC 2010 March 11.
NIH-PA Author Manuscript
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For the full marker set, 11 of the 16 possible subhaplotypes were observed at a frequency ≥
1% (data not shown). The frequency distribution of these subhaplotypes was not significantly
different between cases and control subjects (χ2 = 10.57; degrees of freedom, 10; global p =
0.39). Next, we considered a subset of two H1-SNPs (rs242562 and rs2435207) that defined
the "AA" and "AG" subhaplotypes previously reported to associate with PD.27 There was no
significant difference in the overall distribution of subhaplotypes (χ2 = 4.78; degrees of
freedom, 3; global p = 0.19) or in the frequencies of the AA and AG subhaplotypes in cases
versus control subjects (see Supplementary Table S1). Of the remaining subhaplotypes, one
(GA) was underrepresented among cases at a marginally significant level (OR, 0.83; 95% CI,
Finally, we examined a subset of three H1-SNPs (rs242562, rs3785883, and rs2471738) that
best captured the variation within the "H1c" subhaplotype28 reported to associate with the
tauopathies.28–30 There was no significant difference in the overall subhaplotype distribution
(χ2 = 5.85; degrees of freedom, 7; global p = 0.56) or in the frequencies of any of the eight
individual subhaplotypes observed between cases and control subjects (see Supplementary
Table S2). Subhaplotype frequencies from a previous study on PSP and CBD29 are provided
for reference. The frequencies of the "AGT" and "GGC" subhaplotypes, which are equivalent
to the two subhaplotypes reported to associate with PSP,29 were nearly identical in PD patients
and control subjects (AGT: OR, 1.04; 95% CI, 0.89 –1.22; GGC: OR, 1.04; 95% CI, 0.92–
Nearly all of the genes nominated as risk factors for typical late-onset PD have either not yet
undergone or failed appropriate replication,36–39 with a few notable exceptions (eg, SNCA
REP1 polymorphism).40 Two previous meta-analyses concluded that the MAPT H1 haplotype
might confer susceptibility for PD,20,24 but these conclusions must be interpreted with caution
for two reasons: (1) individual-level data were not available to account for important covariates,
and (2) substantial differences in study design likely existed among the publications selected
for analysis (eg, method of PD diagnosis). We believe that our study, which replicates this
finding in a large case–control sample in which standardized diagnostic criteria and data
collection procedures were used, constitutes a major step toward establishing the MAPT H1
clade as a risk factor in PD. Although the association we observed between the H1/H1 diplotype
and PD was highly significant ( p = 8 × 10−7), the effect size was rather modest (OR, 1.46;
95% CI, 1.25–1.69) but fell within the range thought typical for genetic determinants in
complex diseases.41 This underscores the need for investigators to conduct future PD genetic
association studies in large samples and might explain, in part, the lack of reproducibility
among previous case–control studies on MAPT variants in PD (see Table 1).
Given that the H1 clade represents a risk factor for PD, the true (functional) risk allele(s) could,
in theory, reside at any position within an approximately 900kb region that includes genes other
than MAPT such as CRHR1 and IMP5. Thus, Skipper and colleagues' report27 that a
subhaplotype within the H1 clade was overrepresented in PD was potentially important
because, if validated, it would narrow the location of the risk variant(s) to the 5′ half of
MAPT itself. Among H1/H1 subjects, the authors observed a twofold greater frequency of the
"AA" subhaplotype, defined by rs242562 and rs2435207, in a subset of 81 "probable" PD
patients in comparison with 81 matched control subjects from an isolated population in Norway
(see Supplementary Table S1). They also noted substantially greater LD among these and
nearby H1-SNPs in cases versus control subjects. In contrast, we found nearly identical
frequencies of the AA subhaplotype and similar patterns of LD in cases (n = 1,187) and control
subjects (n = 1,191) of the H1/H1 diplotype (see Supplementary Table S1 and the Fig).
Assuming that our data are representative of the outbred "white" population of North America,
Zabetian et al.Page 5
Ann Neurol. Author manuscript; available in PMC 2010 March 11.
NIH-PA Author Manuscript
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(ex: Florence, Positano)
To hold, book, or get pricing for the property.
This nice estate is located in a hilly and wooded area 7 km from the charming town of Todi. Only 2 km from the E-45 highway connecting Orte and Ravenna, it is a convenient location for visiting Umbria. The small village of Pian di San Martino, with a bar, post office and church, is less than 1 km away. In Ponterio there is a supermarket, pharmacy, two banks, cafes, and a restaurant, as well as a bus stop and a local train station that links Sansepolcro to Terni.
Nearby Attractions: Museum of wine (Torgiano), Marmore waterfalls (rafting, canyoning and canoing), Solomeo (cashmere), Deruta (ceramics), Montecastello Vibio (smallest theatre in the world), Golf clubs: Santa Sabina and Lamborghini (Perugia).
Ground floor: There is a living/dining/kitchen room, and guest bathroom with a WC and sink. In the kitchen are a 4-burner gas cook top, electric oven, refrigerator, freezer, etc.
First floor: Up 20 steps is the first floor. There is a bedroom with a queen-size bed (160 cm x 190 cm), a twin-bedded room (each bed is 85 cm x 190 cm), and a bathroom with a shower, sink, bidet and WC. The wooden furniture and accents have been created by a craftsman-artist. There is independent heating, with units in each room.
Extra Services: The following are listed as an aid for trip planning; the services and prices are approximate and cannot be guaranteed by Rentvillas. All extra services are payable locally in cash.
For exact pricing and conditions, click the View Availability button and then click View Pricing and Conditions.
Please note: Official Arrival Times:
* These prices and conditions may change based on your arrival date and length of stay. For exact conditions, please click on the View Availability button, enter your dates, and then click on View Pricing and Conditions.
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Our onsite manager was super helpful. He answered all our questions about visiting the various towns, plus supplied us with train schedules for Rome and maps and booklets of Umbria. He also made booking for local musical events in the various towns. We did get to see and hear a concert in the smallest theatre in Europe. What a treat!
Enjoyed Most:
Every morning we would see a magnificant view of our hilltown, Todi. The sun was always shining on the towers and was delightful to see. The evenings were much the same. We also had access to satellite TV in the large meeting room.
Enjoyed Least:
We did not find anything not to like. The grounds were well maintained as was the pool. We had access to the fruits and vegetables grown in the area. What a pleasant surprise and treat. We especially enjoyed the figs and local tomatoes.
Surrounding Area:
We enjoyed heading down the hill and waving at all the locals who waved back in return. We were within 6 minutes to E 45 that took us to Assisi, Deruta, Perugia, Todi, Monte Castello de Vibia, Orvieto. Spello, and Spoleto and the charming wine village, Montefalco. We also were able to train it to Roma from Terni which was a 30 minute drive from Podere San Martino.
Nearby Events or Locales:
The small town of Pian di San Martino had a post office, church and small cafe. The post office was never very busy and we never waited in line. While we could not walk there, it was only a 5 minute drive down the hill. A nice Supermercato was only 8 minutes away from our apartment and you could find all the necessary items you would ever want.
Tips or Restaurants:
You do have to bring TP and washing powder plus dishwashing soap. Other than that you could visit the Supermercato and buy whatever you needed and forgot to pack. All the restaurants were excellent in Todi and all the surrounding towns. Never had a bad meal, plus wine was great. We enjoyed "The Umbria" and "Panne and Vino" in Todi. Just yummy! Don't bother with any of the hotel restaurants.
Check In Out:
Not a problem!
Claudette, September


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It was just a few short weeks ago that Superstorm Sandy was causing us nothing but panic and grief. It was one problem right after another making those few days feel like an eternity, but I think we can agree that it gave us new appreciation for simple pleasures like brewing a cup of coffee or taking a hot shower. As often happens in times of sacrifice, we grew in solidarity with our neighbors, pulling through with a sense that we were "all in this together."
Then the lights came back on, the heat started working, gas stations came back online and we happily started to forget about Sandy. There were, of course, expensive and inconvenient repairs to be made, and donations to be sent, but for most of us on this part of the Island, life pretty much returned to "normal."
Writing this weekly column is one of my favorite things to do as your state senator. While it allows me to reflect on issues directly with you, it's also been great for encouraging feedback that has been incredibly helpful to me as a freshman senator. From its inception, I wanted to avoid the typical government laundry list of events and notices that you might expect from legislators. Instead, I wanted this column to be something readers look for, a more honest and readable "inside" look at the workings of state government, warts and all.
With that in mind, I'd like to share with you what I perceive as one of the more pressing issues facing our state and particularly Long Island.
If you frequent Elmont, you know Norma DeBartolo. She's everywhere.
DeBartolo works for the Elmont School District as a special assistant to the superintendent of schools for community affairs. She can often be seen at many events in the Elmont community, including the position of grand marshal of the Belmont Stakes Parade.
DeBartolo will retire after many dedicated years to the school district this coming year. I commend Norma for her service to the district and the community of Elmont, where I called home for a good chunk of my life.
The hallways were strewn with garland. The tree was set up near the principal's office and holiday cheer aplenty at Covert Avenue School during my time there. I remember being a solider in The Nutcracker and I recall all the pleasantries afoot during the holiday season in the building. From time to time, I recall those memories and, in a positive way, dwell on what was. An era I will cherish forever, Covert Avenue is a Christmas memory worth keeping.
Elections are supposed to determine, among other things, how revenue raised from taxes is spent. Should people who earn more money pay even more than they do to the government via taxes? The answer seems to be yes. If they pay more taxes are they entitled to more government services and entitlements? The answer is clearly no. Will people who pay no income tax get less than they do now? The answer is that they will certainly get more.
Equality before the law is the bedrock of our Constitution; economic equality is an entirely different species governed by asymmetrical and counter-intuitive bureaucratic rules and guidelines. Economics is colored by politics and the winning of constituencies. To the victor belongs the spoils and the Democrats enjoyed an impressive victory in November. But elections are not a putsch and American democracy is not a diktat. The minority party has rights and let's not forget that the Republicans retained a majority in the House of Representatives.
Football youngsters ages 7 to 14 got the experience of a lifetime on Nov. 17 at Hofstra University…personalized instruction from New York Giants wide receiver Hakeem Nicks. The kids were beaming with excitement. Not one child was turned away; smiles all around. I'm surprised more events like this haven't occurred at the school, which has a state-of-the-art practice bubble, where the event took place.
"It's the economy, stupid," is a famous cliché for political shortsightedness. We all know what the economy can do politically both for and against the president. A good economy is likely to re-elect a president with overwhelming numbers and a bad one will most likely mean he will be spending his time raising funds for his presidential library. With the Cold War over and Iraqi forces driven out of Kuwait, President George Herbert Bush thought he could rest on his laurels by treating the 1991 recession with kid gloves. He was wrong. Within 21 months, Bush went from a 91 percent approval rating to losing to a governor from the small state of Arkansas. Barack Obama managed to escape defeat but the campaign gave him and his supporters some anxious moments all because of America's limping economy.
Americans view economic performance as a close blood relation; foreign policy is more like a distant cousin —- you never worry about inviting them over for the holidays. These respective sentiments are a remnant of America's isolationist past; a young nation that proudly and firmly repudiated the monarchial and despotic world in stirring and memorable language. It's an ornament the United States still wears on its sleeve and whose echoes are heard more among Republicans than Democrats.
Hats off to the Floral Park Library giving those without power a chance to warm and charge up after Hurricane Sandy rocked Long Island, leaving hundreds of thousands without power. Everything from extension cords and surge protectors were available to those who strolled in looking for some normalcy.
The narrative goes something like this: Hurricanes Sandy and Irene were no coincidence, but were caused by the phenomenon of global warming. These storms are the harbinger of the new normal. To deny climate change in the face of this new reality is to deny science itself.
The culprit is modern civilization with its fossil fuels, transportation, landfills and its patterns of land use all of which has resulted in ominous atmospheric changes that produce extreme weather. The only alternative, and it must begin now, is to transition from fossil fuels to renewable energy, otherwise, say the doomsayers, we're doomed.
It took me 45 minutes to get home from work on Wednesday, Nov. 7 when Athena hit Long Island, which is an eternity because I live close. People were screaming at each other, horns were blaring throughout Old Country Road and I actually had to get out of my car and plead with a driver to let me over so I could make a right turn.
To get a head start on the commute the next morning, I shoveled my car, three other cars, my landlord's path (he's 90) and the steps leading up to my dwelling. Hand to God.
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Roll Call 10/24 Millineum
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Going Green Makes Air Cargo More Profitable
By Patrick Burnson, Executive Editor
September 04, 2013 - SCMR Editorial
September 04, 2013 - SCMR Editorial
With the triennial ICAO Global Assembly convening in Montreal later this month, the International Air Cargo Association (TIACA) is placing a new emphasis on its strong support for a global solution to aviation emissions.
Read more at Logistics Management.
About the Author
Patrick Burnson
Executive Editor
Executive Editor
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Information abounds about the growing trend of electric lift trucks and the advantages and disadvantages of the electric solution. Amid all of the information from so many sources, what's the truth about electric lift trucks? This complimentary white paper breaks through the clutter to review why electric lift trucks are gaining in popularity and also to review their challenges, as well as their economic and environmental benefits.
Three weeks after initiating a coordinated series of slowdowns that have mired the major West Coast ports of Tacoma, Seattle, Oakland, Los Angeles and Long Beach, the ILWU has pushed away from the bargaining table.
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Patrick Burnson is executive editor for Logistics Management and Supply Chain Management Review. Patrick covers international trade, global logistics, and supply chain management. He lives and works in San Francisco, providing readers with a Pacific Rim perspective on industry trends and forecasts. Contact Patrick Burnson


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Mob psychology feeds a need to belong -- and police efforts can backfire.
A new study finds that cleanliness may just be next to godliness. And feeling disgusted? Eh, not so much. It turns out feeling disgust can switch on some crazy defense mechanisms that make us less ethical. We'd better let Trace explain.
News reports claim that a 'mother's intuition' helped rescue a Utah girl from an abductor, but a closer look raises questions. Continue reading →
A Manhattan mother was found guilty in the death of her autistic son, who she killed because of a discredited communication technique. Continue reading →
The sensation some people get of a foreign presence in a room can be recreated in a lab. The research could help patients with schizophrenia. Continue reading →
Does having lots of space around you make you more conservative?
Every month people choose to suddenly disappear and walk away from their lives. Here's a look at some reasons why. Continue reading →
While Ebola is killing thousands in Africa and reaching the United States, many are joking about it. Why? Continue reading →
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Miami motorists will drop their horseless car off at the Royal Palm Resort, where Beachsports Valet's team of expert car-corrallers will Tetris the automobiles into tessellations aesthetically pleasing to both valet and vehicle. After the valets tuck the cars in and kiss them each goodnight, the autos will dream sweet dreams of orange-scented oil changes and toffee-flavored tune-ups.
Sometimes called "speed-dating 2.0," SpeedMiami Dating is part of a multicity enterprise created by Anoush Stevenson, who brought the events to the U.S. from England in 2007. The idea was to eliminate some of the common shortcomings of conventional speed dating, such as cheesy hosts, boring events, and awkward atmospherics. The SpeedMiami approach to dating events has attracted major media attention for sidestepping the pitfalls with elegant venues and novel style. When Anoush brought her matchmaking brainchild across the pond, she didn't alter much. The two-hour events still have hosts who are all from the UK and infuse the festivities with their high-spirited English cheekiness. Miami events are held at trendy spots such as Cafeina and Kyma Lounge.
The Biscayne Xpress Water Taxi glides across Biscayne Bay, circling through its three stops—Bayside Marketplace, the Miami Beach Marina, and the downtown Riverwalk station—in a constant two-hour loop. Up to 42 passengers drink in views of coastal Miami and its gamboling manatees and pelicans as crew members impart juicy factoids about the city to visitors. At the Bayside Marketplace stop, patrons can browse a 120-store shopping complex or charter a fishing boat at Pier 5, whereas the Miami Beach Arena stop drops seafarers near a glut of restaurants, and the downtown Riverwalk station delivers visitors straight into the city's rhythmically beating heart.
The SoBe Shuttle provides an easy way to get around in South Florida with hourly shuttles that run four days a week between Fort Lauderdale and Miami or South Beach. Evening shuttles are available Thursday–Sunday, with return trips leaving South Beach as late as 5 a.m. On Saturday and Sunday, daytime shuttles carry passengers to and from Miami's famous white-sand beaches. Each WiFi-equipped shuttle is chauffeured by an experienced driver and contains a television set and refrigerator, perfect for storing leftovers or teaching a goldfish about winter.
At each of Miami Car Care's more than 20 locations, technicians stand by with tools and mechanical know-how, ready to restore cars back to peak performance. The techs offer full-service oil changes, tire rotations, flat-tire repairs, and diagnostics. They also conduct comprehensive vehicle inspections, wherein they check brakes, lights, wipers, and tires to make sure everything's in working order and nothing's turned Luddite.
Martino Tire's ASE-certified technicians can install new tires, rotate existing tires and balance wheels, and perform a variety of other automotive services, such as brake repairs, oil changes, and realignments. Martino Tire carries tires from brands such as Michelin, BFGoodrich, and Goodyear.


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Chinese checkers; Checking out Skype; JTRS in plain English
"DOD to conduct security standdown"
"Can only you hear me now?"
Chinese checkers
Chinese President Hu Jintao made nice with Bill Gates during his U.S. visit last week. He promised that companies in his country would engage in a novel practice — buying rather than pirating Microsoft software. Microsoft estimates that 90 percent of its software used in China is pirated.
We suggest Hu make nice with the Defense Department by halting probes of DOD networks, such as the large-scale scans of Marine Corps networks in Okinawa and southern California earlier this year.
We picked up reports that the Marines detected more than 30,000 FTP scan and access attempts against those networks over a short period. All those probes traced back to Chinese IP addresses.
At about the same time, the Joint Task Force-Global Network Operations detected malicious e-mail sent to DOD users. Each message had a Word attachment containing a macro that could automatically change or delete files or cause a computer to communicate with an outside Web site. In this case, JTF-GNO found that the macro would tell an infected computer to phone home to a Chinese IP address.
Because China maintains tight control of its Internet domains — with gear purchased from blue chip U.S. network hardware companies — it's hard to imagine those probes were conducted by bored Chinese teenagers.
Call me a cynic — or a realist — but I bet those probes were conducted by Chinese military or intelligence agencies, although Hu might have persuaded those Chinese network checkers to knock it off during his visit last week.
Checking out Skype
Sometimes DOD needs to defend its networks from themselves.
Although running commercial peer-to-peer applications is supposed to be a real no-no on DOD networks, the JTF found earlier this year that several Navy Marine Corps Intranet (NMCI) and Marine Corps hosts had installed and were using the Skype P2P voice-over-IP application.
Skype has at least three known vulnerabilities that hackers can exploit to execute malicious codes. But the JTF determined that the culprits were not PFCs looking for a way to make cheap phone calls. Marines were running an official test to see if Skype would be a good VOIP solution.
The Marine Corps Computer Emergency Response Team, we hear, quickly put an IP block on Marine networks to block connections to the Skype site.
One wonders why the Marines don't just follow the lead of the Naval Sea Systems Command HQ at the Washington Navy Yard, which has 4,500 Cisco VOIP seats and 1,736 Avaya seats on NMCI at a cost of $1.4 million for fiscal 2006.
JTRS in plain English
We salute Vic Popik, ops director for the Joint Tactical Radio System Program Executive Office at the Space and Naval Warfare Systems Command, for doing something never done in the troubled project's history — explaining its problems and deficiencies in plain English without bureaucratic doublespeak.
Popik, in a presentation to an industry gathering last month, said JTRS development and fielding suffered because of:
That's not all, folks. Popik said a major problem with JTRS was that DOD originally conceived of it as a legacy radio replacement program but then let it evolve into a network-centric radio program without considering the impact.
When Popik finishes his Spawar work, we would like to see him take a similar approach to the delayed and over-budget Transformational Satellite program, which we predict will turn into the JTRS of this decade.
Intercept something? Send it to bbrewin@ fcw.com.
The awards were handed out last week at FCW Events' Knowledge Management conference and exhibition in Washington, D.C.
The 2006 Knowledge Management Award winners are:
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Steve Kelman considers the costs of corruption in Mexico, China, and most developing countries -- and argues that Americans should keep their own government troubles in perspective.
Agency leaders must proactively invest time, energy and resources to shape the future rather than reactively wait for change to happen.
Meet 24 men and women who are driving key changes in federal IT -- and shaping up as the community's likely leaders of tomorrow.
GSA's administrator talks with FCW about short-term hiring, long-term planning and Robert Frost.
Without a future vision and an appetite for risk, reforms lead down a rabbit hole. There is a better way.
VA's top tech official says he is balancing risks while trying to keep the department's online services open for business.
After five years on the job, the founding director of the Office of Government Information Services believes that a deeper understanding and acceptance of FOIA is seeping into the federal government.
The September attack, made public Nov. 10, potentially puts customer and employee personal information at risk, including addresses, Social Security numbers and emails.
The General Services Administration's Matthew Goodrich predicts more agency-driven authorizations and previews a new two-year road map.
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Practice Biology, Biochemistry With 3 Sample MCAT Questions
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Normal Barbie: Photos Imagine Iconic Doll With "Real" Measurementsby Free Britney at . Updated at . Comments
Meet "normal" Barbie!
Using a 3-D computer model, an artist created photos of the classic Mattel doll using the proportions of the average 19-year-old American woman.
Here's what a "real" Barbie would look like:
Artist Nickolay Lamm of MyDeals (dot) com created the rendering of Barbie as your average girl, not the tall, impossibly skinny version sold for decades.
Demi Lovato praised the "new" Barbie on Twitter, and based on the reaction these drawings have received on the web, she likely won't be the last to.
"I created normal Barbie because I wanted to show that average is beautiful,'' Lamm told Today.
"If the average-looking Barbie looks this good and if there's even a chance of Barbie negatively influencing young girls, why not make one?"
Lamm noted that there are "different interpretations" of what is considered "average," but he used official CDC figures to make it "pretty close.''
He cites research suggesting Barbie may lead to heightened body dissatisfaction among girls, unhealthy eating behaviors such as desire to eat less.
Not likely the case with "Normal" Barbie, however. Girl's got BACK!
What do you think? Do you like the more "normal" looking Barbie?
I think they should make Barbies of all colors and styles= fat, short, tall, thin. Since so much of our population is now overweight - I think they should make an overweight Barbie with a piece of fried chicken in her hand while standing on a scale.
That would be awesome as hell if they did ;-) funny too!
librarist I agree with you 100%
you show every message two times?