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Search Results: 'uterine fibroids'
Letters to My Sisters: Plain Truths and Straightforward Advice from a Gynecologist
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My Hormones are Killing Me - My Struggle with Adenomyosis and Estrogen Dominance
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THIS VERSION IS TEXT ONLY - NO PHOTOS. When it comes to disorders of the female reproductive tract, most people have heard of endometriosis, and most know of someone who has suffered from this... More > disorder. However, adenomyosis is a closely related condition, yet very few people are aware of it. The purpose of this book is to bring awareness to this little known disorder of the uterus by telling my own story of my 17 year medical struggle with adenomyosis. In addition, this book delves into hormonal imbalances which could lead to this condition, particularly estrogen dominance. There are many things that can be done to lessen the symptoms of adenomyosis and to help balance hormonal levels, from dietary changes to the use of natural progesterone cream. However, much more research needs to be done since adenomyosis typically can't be diagnosed definitely until hysterectomy. I hope by writing this book I will be able to help others who might be strugglilng with a similar gynecological condition.< Less
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Cool GamesAction»Misc»
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Birchwood House Rental Photos and Description
Five bedrooms, three bathrooms, sleeps 13
It's the north woods vacation, minus "roughing it". The private Birchwood Cabin is in Birchwood, Wisconsin on Birch Lake in Washburn County (between Hayward and Rice Lake). It's a beautiful five bedroom, three bathroom lake home on a wooded lot. Outdoors, you may choose to fish from the dock, sit by the fire pit, enjoy the view from the spacious deck or soak in the hot tub. Inside, you'll find a main level kitchen, living room with gas fireplace and plasma HD TV, laundry room, bathroom, two twin bunk bedroom, and queen bedroom. Upstairs is the master bedroom and bathroom loft featuring plasma TV and Jacuzzi tub. In the lower level we have in-floor heat, a family / game room with home theater system, game table, cable connections to your video game systems, bedroom w/ queen, bedroom w/ two twins plus trundle & bathroom. Free wifi.
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Not that birders need a specific day to think about birds, today, at least in the United States, is the one holiday on the calender that ostensibly promotes birds amongst the rest of the population. Granted this appreciation is primarily gustatory in nature, but it's something.
The ABA would like to with you and yours a happy and healthy day full of friends, family, and winter finches.
For those looking for some turkey-related reading this holiday, please head over to 10,000 Birds, where Greg Laden offers a fascinating overview of how this wild bird became domesticated and then wild again. It's a good read.
Happy Holiday!
Nate Swick
Latest posts by Nate Swick (see all)
- Call for 2014 ABA Award Nominations! - November 25, 2014 8:00
- Blog Birding #212 - November 24, 2014 8:00
- ABA Classifieds Back by Popular Demand! - November 22, 2014 8:00
- Rare Bird Alert: November 21, 2014 - November 21, 2014 8:00
- Help the ABA Finish Strong in 2014! - November 20, 2014 12:00


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Dr. Kenneth Castor will be retiring from Children's Medical Group on
We are cancelling the flu clinics scheduled for November, 8th and November,
MONDAY THROUGH FRIDAY WALK IN SHOT HOURS are 9:30 AM - 11:30 AM 2:00 PM -
The physicians of Children's Medical Group, P.A. want to welcome your family to our group. We strive to provide you with quality medical care. We are open and staffed 364 days a year which include Saturday, Sunday and holidays excluding Christmas. Patients are routinely seen in the office from 9:15 am until approximately 5:30 pm by our physicians. After 5:30 pm a physician will see patients for emergency and sick visits only.
We are looking forward to serving you and your children.


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We contained our dog in the attached-to-the-house garage. The pizza guy (came in an UNMARKED car) instead of walking up the walkway to the front door like others always do... went to our garage window, set the pizza down on the ground, looked into the garage door window, then opened the door! He let the dog loose, and the dog went after his butt and bit him. He closed the door with the dog outside and he (delivery guy) inside our garage. I heard things falling in the garage. My husband went to investigate and it's the pizza guy inside and the dog and the food outside the garage door! Does the pizza guy have the right to enter a home/garage (even if unlocked) without being invited? Also, I did NOT give instructions to "enter through garage. " Are we legally responsible for his bite?
I don't think he was trespassing if that is what you mean. Whether you'd be on the hook for the bite, I don't think so either. But if you are sued turn the papers over to your insurance carrier and let them worry about it.
In New York, the owner is strictly liable for a dog that bites another if the owner knew or should have known of the dog's "vicious propensities." If your dog has not shown vicious propensities in the past, and you have never had problems with your dog doing anything dangerous to anyone else, the case is likely defensible.
Either way, you need to notify your insurance carrier so they can investigate and provide a defense in the event you are sued.
I would consult with your insurance company right away so they can begin protecting your rights. The answer will likely depend on your local laws. Here in Nevada the analysis would be whether he was invited or not, whether his actions were reasonable (in opening the garage door), whether he had any indication there was a dog in the garage, whether the alternate access you talk about (walkway) was easily accessible or whether it was more difficult to reach, and whether he had been to your premises before and knew of the dog. There are obviously many other issues, but these would be the first questions I would want to know. My initial inclination is that you would NOT be responsible because the delivery guy's actions were unreasonable in opening the garage.
Doesn't appear he was trespassing but I would notify your homeowners insurance to investigate the incident.
You are strictly liable for a dog that has known or inferrable vicious propensities. Your pizza guy was an invitee, not a trespasser, at least initially. His "case" begins to deteriorate when he opened the garage door, which causes wrinkles. Fortunately, you promptly notified your home insurance carrier to avoid any disclaimer for late notice, and let them handle this. That's why you've been paying all those insurance premiums all those years!
Simply turn the matter over to your homeowner's insurance carrier to resolve this for you.
First, notify your homeowner's insurance carrier. They will handle the matter in your defense. As an aside, and solely based on your scenario, it would appear that there is a strong argument to be made that the delivery boy bears a significant percentage of culpability for this event. It is one thing for him to be attacked while on your property but in the open. It is another for him to enter inside a portion of the premises uninvited. In any event, this type of incident will be covered under your homeowner's policy.
When you ordered the pizza you invited the delivery person to your home. I he or she wants sure what door was for the house then they can knock etc but they cannot just enter without being invited in. You are liable for your dog if the dog had a known vicious propensity. Why was the dog in the garage in the first place? Is this a guard dog or attack dog? If so, then it propensity is known and you may have a duty to warn of its presence. The facts o your question make it unlikely that the delivery person will succeed with a case. Notify your homeowners carrier.
I suggest you advise your homeowners insurance carrier about this incident.
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Yesterday, 09:11 PMHeh. I think I would've got it if I didn't buy GSCE yesterday (and subsequently uninstalled R3E).21 replies | 216 view(s)
Yesterday, 08:04 PMI can confirm, apply the above if you don't want grey untextured cars on the grid.21 replies | 216 view(s)
Yesterday, 08:04 PMNice, can't wait to totally miss the chicane braking point. Ah cmon, don't be silly now. They're legendary creatures just like unicorns.463 replies | 17351 view(s)
Yesterday, 12:56 PMYes yes, the Race07 stuff is very solid and there's a lot of variety on offer to boot. It's also easy to race online so let's do it sometime, should...21 replies | 216 view(s)
26-11-2014, 09:51 PMProlar Bear replied to a thread The Game Stock Car Extreme corner in Racing gamesI'm *this* close to caving in and buying this. 38 mins left on my demo, and the Vees are ludicrous. UPDATE: hello Reiza club.140 replies | 6484 view(s)
26-11-2014, 09:48 PMAh, apologies. Didn't think that was you - I'll add the result now. Let's keep zitron as the winner for now, but here's a late trophy for you.463 replies | 17351 view(s)
26-11-2014, 09:44 PMYou only really need a few of these, namely GTR 2, GTL and Race Injection+GTR Evo, but the bundle will be cheaper than buying those separately. Go...21 replies | 216 view(s)
26-11-2014, 03:41 PMResults for Blackwood x Zonda R. And this week's winner is Thee Zitron! Zitron | Wheel | ...463 replies | 17351 view(s)
25-11-2014, 01:42 PMProlar Bear replied to a thread The Inevitable Dark Souls II for PC Official Thread in PC Gaming DiscussionYup, Namco isn't being exactly communicative. From what I gather the NPC\Item\AI improvements will be free, while there will be a "DX11" version...1546 replies | 75498 view(s)
25-11-2014, 11:39 AMProlar Bear replied to a thread The Inevitable Dark Souls II for PC Official Thread in PC Gaming DiscussionPretty excited for this. I'm still stuck at Sinh so I'm 1/3rd of the way through the DLC, more or less, and I haven't yet completed my first...1546 replies | 75498 view(s)
25-11-2014, 11:38 AMHey, I actually like the career progression. The career and custom championships can coexist in my opinion. What irks me is that AC got the big...463 replies | 17351 view(s)
24-11-2014, 08:08 PMI tried some laps and couldn't stay on the track. I did lose some of my touch but AC not accepting new laps after restarting session is just...463 replies | 17351 view(s)
24-11-2014, 08:07 PMProlar Bear replied to a thread Real life motorsports. in Racing gamesNot everyday you see formula car parts treated like that. Anyway shame about Rosberg not being able to rely on his car in Abu Dhabi.18 replies | 399 view(s)
24-11-2014, 06:15 PMProlar Bear replied to a thread The Game Stock Car Extreme corner in Racing gamesWelp, Reiza is about to take the world by storm hopefully. I know I look forward to the Steam release.140 replies | 6484 view(s)
23-11-2014, 03:47 PMProlar Bear replied to a thread Share your videos! in Racing games...I'm just mad that AC still hasn't got a single Porsche or RUF.75 replies | 2355 view(s)
22-11-2014, 09:57 PMProlar Bear replied to a thread Real life motorsports. in Racing gamesI chuckled pretty hard at that, kudos. Curiously enough I don't really watch real life motorsports, nor do I race. I was a F1 fan as kid but not...18 replies | 399 view(s)
22-11-2014, 05:55 PMProlar Bear replied to a thread The name that game challenge in PC Gaming DiscussionC is indeed Zen Pinball 2. I is Teleglitch.2620 replies | 127395 view(s)
22-11-2014, 03:19 PMProlar Bear replied to a thread Hearth, Stone, Pals in Game Clubs And General Sociability OkThe other day I had trouble logging in, weird.1031 replies | 50323 view(s)
22-11-2014, 11:35 AMProlar Bear replied to a thread Wasteland 2 : Reviews & Reception in PC Gaming DiscussionI have worked on the crowdsourced translation for this game. How did it turn out? I remember the dialogue looked pretty good, and that, yes, the...245 replies | 22090 view(s)
21-11-2014, 09:15 PMProlar Bear replied to a thread Designing a better Time/Score Attack System in Racing gamesBrilliant. Can't wait to try it again.27 replies | 1010 view(s)
20-11-2014, 10:26 PMProlar Bear replied to a thread The RPSkid Assetto Corsa Racing Club! in Racing gamesThanks for setting it up in the first place, it was a blast. I'm looking forward to race you guys again...just not this week. Also, we can more...126 replies | 3493 view(s)
20-11-2014, 09:31 PMProlar Bear replied to a thread The RPSkid Assetto Corsa Racing Club! in Racing gamesEh, I want to race but at the moment my days are far too busy - when I get to the evening I just don't have the right concentration to play a sim. ...126 replies | 3493 view(s)
18-11-2014, 09:37 PMUh, I think I put a very non-interesting time on the standard AC leaderboard for the last challenge. Meanwhile, pretty stoked to try this one! I...463 replies | 17351 view(s)
14-11-2014, 02:17 PMProlar Bear replied to a thread Assetto Corsa - the wishlist thread in Racing gamesThe Zakspeed Capri is a lot of fun, good mod. Kunos dev interview here. It's in Italian so I'm just gonna make a bullet list with the main points:...110 replies | 4225 view(s)
14-11-2014, 11:24 AMProlar Bear replied to a thread HARD MODE UNLOCKED - Games you make more difficult in PC Gaming DiscussionOh, I'm gonna add racing games and sims to the list. Driving aids are only crutches to help with getting up to speed (pun intended), after that you...33 replies | 1619 view(s)
14-11-2014, 10:30 AMProlar Bear replied to a thread HARD MODE UNLOCKED - Games you make more difficult in PC Gaming DiscussionI began FO:NV on survival mode, felt great. I actually didn't get far because I was burned out from finishing FO3 immediately before, but I'll be...33 replies | 1619 view(s)
14-11-2014, 10:28 AMThanks for the tips, but I wasn't complaining about the E30 in particular - it's more like an AC-specific sensation of understeer regardless of...463 replies | 17351 view(s)
13-11-2014, 09:33 PMI think I'm stuck on 2:25 as well. After spending some more time with GTL, Race and GTR2 I can't fathom why AC feels so understeery. EDIT: FOV...463 replies | 17351 view(s)
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I am searching for ANY information on Bald Hill Cemetery located about 1 1/2 miles North of Princeton on Bald Hill in Patoka Township. If you have burial listings or photographs, or you have seen this cemetery and can tell me where it was, please contact me. Members of the James Brown and Hudson Brown families are believed to be buried there in the early to mid 1800's.
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EBC Yellow Stuff Brake Pads DP41414R
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text: First Venezuela, now Argentina, and Brazil is next. Leftist are collapsing some of the once most vibrant and resource rich economies of South America. All three of these countries were prospering and doing great under capitalism and all three have tremendous natural resources and all three are headed down the tubes. This could get real ugly and drag the entire world economy back into a recession. This could trigger the next black swan event if Argentina defaults, again, and drags Brazil down with it. http://www.theguardian.com/world/2014/jan/24/argentinian-peso-freefall-economic-crisis-deepens The peso is suffering its fastest fall since Argentina's 2002 economic collapse as dwindling reserves keep the central bank from trying to prop up the currency by intervening in the foreign exchange market. The 16 percent loss in the peso's official value against the dollar over Wednesday and Thursday could worsen the country's inflation, which is among the worst in Latin America, analysts said. The peso fell from 6.88 per dollar on Tuesday to 7.14 on Wednesday. By Thursday's close, it was at 8 to the dollar. On the black market, where Argentina's currency is even weaker, the peso dropped 6 percent Thursday to 13 per dollar. The sharp depreciation is likely due to a new government strategy of seeking a sudden devaluation instead of a gradual one, said Juan Pablo Ronderos of economic consulting firm abeceb.com. "There was a first sign of this change on Tuesday because the central bank didn't show up (to intervene) until midday, and on Wednesday and today it just disappeared from the market," Ronderos said. "The gradual devaluation wasn't working because the central bank kept on sacrificing lots of its reserves and it kept on being reflected on consumer prices." Analysts expect Argentina's inflation to reach more than 30 percent this year, the second highest rate in Latin America after Venezuela. "The sharp drop will aggravate inflation, although the impact may be mitigated by the fact that some imports will already be purchased at the much weaker black market exchange rate," Neil Shearing, chief emerging market economist at Capital Economics in London, said in a research note. "The bigger picture, though, is that the economic mismanagement of the past decade has once again pushed the country to the brink of a balance of payments crisis," Shearing wrote. Critics of the left-leaning government of President Cristina Kirchner blame economic problems on its higher spending on social programs, expansion of business regulation and nationalisation of some companies. http://www.theguardian.com/business...na-peso-new-crisis-emerging-market-currencies So what happens now? In Argentina, there is the prospect of capital flight, a sharp fall in the peso and higher inflation. In emerging markets more generally there is the prospect of contagion. Brazil, as Argentina's neighbour and a country already identified as one of the fragile five emerging markets (India, Indonesia, Turkey and South Africa are the others), looks most vulnerable. For the global economy, Argentina can be read one of two ways. Either it is a sign that the financial crisis of 2008 has a sting in the tail. Or it is the start of a new one.


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Aug. 26 (Bloomberg) -- Mark Grant, managing director at Southwest Securities, talks about the U.S. economy, stock market, and Federal Reserve monetary policy.
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Posts from Bread
How To Make Bread in the Slow Cooker
Cooking Lessons from The Kitchn
Mastrad Bread Warmer
Product Review
Item: Mastrad Bread Warmer
Price: $39.99
Overall Impression: Versatile for outdoor meals in the summer and holiday meals in the fall and winter. Worth picking up if you like your rolls warm and do a lot of entertaining.
Warm bread that's fresh from the oven is pretty much the best thing ever, no matter the occasion, no matter the time of year. Wrapping warm rolls in a clean dishtowel helps hold in the warmth for a little while — this bread warmer from Mastrad takes things one step further. With its heatable ceramic liner, this basket will keep our rolls toasty from the start of dinner all the way through to second and third helpings.
How to Make Italian Grissini Breadsticks
Cooking Lessons from The Kitchn
For a Savory Breakfast Treat: Make Bialys!
Do savory, stuffed bialys sound as good to you as they do to me right now? If not, then maybe you should watch this video from Delicious Days and see how you feel about it then!
Baking Recipe: Seeded Whole Wheat Overnight Bread
Recipes from The Kitchn
Lately I've been spending weekends in a house upstate that I'm sharing with my friends Hilary and Al. Deciding to share the house with them was a no-brainer: lovely people, great style, a kind and gentle son for Ursula to hang out with, fabulous British accents, and a killer house. What I didn't know until arriving for our first weekend was that Al makes bread every Friday night for toast on Saturday morning. I totally scored.
Quick & Easy Travel Snack: Chia Bread!
For better or worse, rice cakes have become one of my gluten-free travel staples. They're easy to find, are surprisingly sturdy, and make a decent alternative to sandwich bread when staying with non-GF friends and family. Yet rice cakes are boring and not especially nutritious (possibly even bad for you). I plan to replace them with this Super Power Chia Bread from Oh She Glows.
5 Tips for Making Healthier Banana Bread
Want to Bake Bread at Home? Start With These 3 Beginner Bread Recipes
So, I hear you want to bake bread! That's music to my bread-loving ears. Even if you've never opened a package of yeast or taken your KitchenAid's dough hook out of the box, don't worry about a thing. Here are our three easiest, most basic, and most foolproof bread recipes for you to try first, plus plenty of helpful tips and tutorials to make sure your first loaf is a success.
How to Make Soft & Tender Dinner Rolls
Cooking Lessons from The Kitchn
How To Make Easy Rosemary Focaccia
I'll be honest with you: I don't care for focaccia that's topped with a lot of stuff. I like my focaccia to be a simple, herby bread with the emphasis on salt and olive oil. I may allow for one or two additions besides the sea salt, olive oil and herbs. But that's it. You may feel differently, and of course, that's just fine. You can use this recipe as a base for all your favorite focaccia toppings. But just for today, try it plain and simple with a glass of deep red wine and maybe a wedge of cheese on the side. It's really quite delicious!


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Whether it's just the sheer force of the sun, or the fact that the Tube feels like being stuck in the world's worst sauna, the heat can make us all feel a little worse for wear. We love a good face spritz to help us cool down, fix our make up or refresh us after the weather's taken it's toll. Here are ten of the best on the market to help you keep shine at bay and feel a little more cool.
10 Hot Face Sprays To Cool You Down
Rodial Dragon's Blood Hyaluronic Tonic
Try this out for size to shrink pores and soothe your skin from external aggressors, as well as refreshing make up. £33, [a target="_blank" href="http://www.rodial.co.uk">www.rodial.co.uk[/a]
Evian Facial Spray
For when you're just hot, hot, HOT. This will instantly refresh a sweaty face. £3.50, Debenhams
Trilogy Hydrating Mist Toner
This is perfect to soften and hydrate tired, dried-out summer skin. £15.75, [a href="http://feelunique.com">FeelUnique.com [/a]
Clinique Moisture Surge Face Spray
Totally oil-free but full of aloe vera, this is perfect for hydrating dry skin. £21.00, counters nationwide
Vichy Eau Thermale Spa Water
If your skin's hyper-sensitive, this offering from Vichy will help to cool it down. (£7.00, Boots)
Crème de la Mer, The Mist
A luxe buy from Crème de la Mer, this helps to re-energise tired skin. £50.00, John Lewis
Chantecaille Eau Rose de Mai
Rose de Mai only grows in very select parts of the world, making it a prized ingredient. This spray soothes skin and combats fatigue. £50.00, Liberty
MAC Fix+ Finishing Mist
Your best bet for fixing make up, after a spritz of this, you're totally sweat-proof. £15.50, [a target="_blank" href="http://macccosmetics.co.uk">www.maccosmetics.co.uk[/a]
Caudalie Beauty Elixir
A celeb fave (Victoria's Beckham's a fan!) this spray is antibacterial, making it idea for oiler skins. And it smells lush. £32.00, [a href="http://uk.caudalie.com">Caudalie[/a]
Jurlique Rose Water Balancing Mist
Jurlique's best-seller promotes a healthy, radiant complexion. £16.50, [a target="_blank" href="http://jurlique.co.uk">www.jurlique.co.uk[/a]
Urban Decay All Nighter Make Up Setting Spray
Oil and paraben free, this has nifty technology to actually lower the temperature of your make uo and keep it fixed. £19, Debenhams
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text: Friday night was our first time to Vivo's. Having read some of the reviews, I was intrigued to come for a visit. Our experience did not disappoint. Pat, our server, was knowledgeable, attentive, and made excellent suggestions. We asked for and then followed his suggestions for all aspects of the meal and his selections were spot on. The grilled Caesar... More


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10% OFF Vintage collectible Fenton milk glass silver crest edge on the 13 inch basket that they started to make in 1952 still in excellent condition. The basket is very weighty. The basket gives off a ring when tapped on the edge. There is no damage to the basket or the handle.
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Learn a few commonly overlooked signs that you need to take your health more seriously.
You've been told these food are healthy...but they could actually be ruining your diet! Find out the truth behind unhealthy "health foods" now!
Fast food joints offer healthy options too! Find out what to order when you need to grab some food on the go.
Nicea and Scott have set out on a new fitness program...find out what they are doing to get healthy, and how you can join in on their quest!
Total Health and Fitness has helped one local woman through her inspirational weight loss journey. She has lost weight in the triple digits! Learn about the changes she has made to transform her life and body!
The 12 Week Program of The Younger You is almost over! See how the 5 contestants lost weight and gets motivated, and how you can too!
It is important to find a diet center that won't just help you lose weight, but will also teach you a new and healthy lifestyle. This decision has a big impact on your health--and we've got advice on making the right choice.
DRAPER, Utah (ABC 4 Utah) - Two months ago, I did a story on fitness gadgets and stumbled across a little nugget of information I never knew. I was starving myself. Not on purpose, I just never knew my fitness baseline so I was eating much less than my body needed.
The pros tell you the most common mistakes they see preventing people from losing fat and toning up.
Cardio isn't always the answer when it comes to weight loss. Too much of a good thing can actually set you back!


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These nachos look like the real deal - no processed cheese or funky ingredients. **For chips Rachael Ray says: 2 bags of corn tortilla chips in 2 colors or different flavors, such as blue corn, red corn, yellow corn, lime flavored, chili flavored or black bean chips - we like the Archer Farms Corn Chips (from Target).
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McSweeney's Night of One Hundred Apocalypses and Other Apocalypses
Thu Sep 12 2013
- Free
Time Out says
Posted: Fri Aug 30 2013
Here's to the hundred apocalypse predictions we've lived through, and here's to a hundred more! Eventually, someone will get it right, but until then, we'll have this McSweeney's event celebrating Lucy Corin's collection, One Hundred Apocalypses and Other Apocalypses, and readings by Nelly Reifler, Justin Taylor and Shelley Jackson. Musical accompaniment will be provided by Julia Weldon, and there will be some end-of-days comedy from George Gordon.
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1731cc, 92bhp, 115mph, Insurance group 15
The Victory Hammer 8-Ball is basically a lower-seat, cheaper specification version of the Hammer muscle bike. It still has the same gutsy motor, but instead of twin front brake discs it has a single caliper and rotor, plain black paint instead of the more upmarket finish usually seen and the suspension is lowered front and rear to drop the seat ...
1584cc, 75bhp, 115mph, Insurance group 15
The Street Glide tries hard to bridge the gap between full-on tourer and custom street bike. The bike is based on Harley's spine frame touring chassis but is 'slammed' for a low mean look. The twin cam 96 cubic inch (1584cc) engine hauls the bike briskly to a comfortable 80mph cruising speed with just the right amount of vibes. As ...
1250cc, 109.2bhp, 145.1mph, Insurance group 16
Harley's cruiser V-Rod has been about since 2001, and the new Muscle is… is just another styling exercise to bolster what is arguably a tired range. The Muscle is essentially a reworked V-Rod with design touches (muscular, flowing lines) to front it up as a serious boulevard traffic light blaster. Except it isn't that muscular – 12.25sec standing quarters anyone?
1130cc, 120bhp, 144mph, Insurance group 17
'Designed for Europe' Harley-Davidson Street Rod is a sports version of the Harley-Davidson V-Rod. So while the engine remains the same as its cruiser cousin, the Harley-Davidson Street Rod's chassis has been modified to turn it into a handler. It works, too, delivering a much more invigorating ride – still no Suzuki GSX-R1000, not by a long chalk.
1580cc, 67bhp, 118mph, Insurance group 16
One of Harley's whackier 'image bikes', in a similar vein to the Harley-Davidson Bad Boy, Street Bob and Night Rod. The Harley-Davidson Night Train is a Europe-only model based on the Softail. It's lean, mean and very black and it goes pretty much as it looks. If you like the style of the Harley-Davidson Night Train you won't be disappointed.
1130cc, 115bhp, 144mph, Insurance group 17
The Harley-Davidson Night Rod is the third derivative of the controversial (but undeniably modern) Harley-Davidson VRSC V-Rod family is for those who like their bikes hot-rod style – and black. In practical terms it's halfway between the laid back Harley-Davidson V-Rod and semi-sporty roadster Harley-Davidson Street Rod. And that's no bad thing: a modern Harley with style and ability.
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Pianist Tanya Gabrielian
Juilliard @ SOPAC: Classical Pianist Tanya Gabrielian in Recital
South Orange Performing Arts Center, Off Route 510 (1 SOPAC Way South Orange, NJ 07079)
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Award-winning pianist Tanya Gabrielian has earned international acclaim through appearances at Carnegie Hall, London's Wigmore Hall, and with the Los Angeles Philharmonic, among dozens of others prestigious venues and collaborations, and released her first CD, Kaleidoscope, in 2010. A member of the Juilliard School's prestigious Artist Diploma program, Gabrielian's SOPAC performance is set to include Bach's Liszt Prelude and Fugue in A Minor for Organ; Beethoven's Sonata Op.111; Debussy's Four Preludes from Bk.II; Ghost Variations by Schumann; and Gounod's Liszt Waltz from Faust.
* Additional fees apply.
All offers for Pianist Tanya Gabrielian have expired.
The last date listed for Pianist Tanya Gabrielian was Sunday March 11, 2012 / 3:00pm.
Currently at South Orange Performing Arts Center
Top NJ Choreographers' Works Performed by Innovative NJ Dance Companies
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I did not frequent the food/ drink area at SOPAC!Holiday Swing w/The Julliard Jazz Ensemble info • Dec 10 2012 star this tip starred
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Excellent; large parking lotHoliday Swing w/The Julliard Jazz Ensemble info • Dec 10 2012 star this tip starred
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Themistocles of Athens (Character)
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- 300: Rise of an Empire (2014) Played by Sullivan Stapleton (as Themistocles)
- The First War for the West (2014) Played by Bohdan Brumerskyj (as Themistocles)
- Au nom d'Athènes (2012) (TV) Played by Jean-Pierre Michael (as Thémistocle)
- Last Stand of the 300 (2007) (TV) Played by Orion Barnes (as Themistocles)
- "Empires: The Greeks - Crucible of Civilization" (2000) TV series Played by Willy Bowman (as Themistocles)
- "Fürkész történetei"
- A Jóslás (????) TV episode, Played by Kálmán Hollai (as Themistocles)
- The 300 Spartans (1962) Played by Ralph Richardson
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Themistocles: [at sword-point standoff with Artemisia] I would rather die free than live as a slave.
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An improved assay method for detecting the presence of an antibody capable of binding with an antigen of a virus is provided. The improvement comprises using a non-human immune antibody which is reactive with an anti-human antibody as a positive control in the assay. Non-human immune IgM and a method of producing the IgM is also provided.
1. In an assay for detecting the presence or absence of a human antibody which binds to an antigen of a virus or a bacteria, comprising the steps of:
(a) contacting a sample of the antigen with a test sample of human biological fluid for times and under conditions sufficient for the antigen and any antibody present in the human biological fluid to form antigen-antibody complexes;
(b) at the same time contacting another sample of the antigen with a positive control comprising a procine antibody to the antigen under the same times and conditions as in step (a), said times and conditions being sufficient for the antigen and the non-human antibody in the positive control to form antigen-antibody complexes; and
(c) detecting the formation of any antigen-antibody complexes in steps (a) and (b) by simultaneously contacting an anti-human antibody with any antigen-antibody complex as formed, for times and under conditions sufficient for any antigen-antibody complexes formed in step (a) and step (b) to react with the anti-human antibody.
2. The assay of claim 1, wherein the non-human immune antibody comprises IgG, IgM or mixtures thereof.
3. The assay of claim 1, wherein the non-human immune antibody is an antibody to a human retrovirus indicative of acquired immune deficiency syndrome (AIDS) or AIDS related complex (ARC).
4. The assay of claim 3, wherein the non-human immune antibody comprises IgG, IgM or mixtures thereof.
5. The assay of claim 4, wherein the non-human immune antibody is a procine immune antibody.
6. The assay of claim 1, wherein the non-human immune antibody is an antibody to HTLV-I.
7. The assay of claim 6, wherein the non-human immune antibody is a porcine immune antibody.
8. The assay of claim 6, wherein the non-human immune antibody comprises IgG, IgM or mixtures thereof.
9. The assay of claim 1, wherein the non-human immune antibody is an antibody to cytomegalovirus (CMV).
10. The assay of claim 9, wherein the non-human immune antibody is a porcine immune antibody.
11. The assay of claim 9, wherein the non-human immune antibody comprises IgG, IgM or mixtures thereof.
12. The assay of claim 1, wherein the virus is selected from the group consisting of HIV-1, HIV-2, HTLV-I, HTLV-II, cytomegalovirus, and Epstein Barr virus.
The present invention relates to the use of a non-human immune antibody, which is capable of reacting with an anti-human antibody, in an assay system for detecting the presence or absence of antibodies to viral and/or bacterial infective agents. In particular, the invention pertains to the use of porcine immune IgG and porcine immune IgM, as a positive control in an assay system. The present invention also pertains to non-human immune IgM, preferably porcine immune IgM and a method of producing it.
Assay systems capable of detecting the presence or absence of antibodies generated in response to the presence of antigens are well known. Such assay systems have proved useful in, inter alia, the diagnosis of various diseases. For example, viral infections, such as AIDS (acquired immune deficiency syndrome) and CMV (cytomegalovirus) may be diagnosed with assays which detect the presence of viral antibodies in patients suspected of having the disease. Examples of such assay systems which employ antigen-antibody binding include ELISA, Western Blot, Quick Western Blots (U.S. Pat. Nos. 4,816,387 and 4,885,235) and RIA. Such diagnostics uniformly include controls to insure the integrity of the test system.
Typically, the diagnostics have both positive and negative controls. The positive control provides pertinent information concerning the activitY of the test system, i.e., that reactive antibodies specific to the antigens used in an antibody test system are bound to the antigens (indicating that the antigens used in the test system are working properly), and that the anti-immunoglobulin used to detect the bound immunoglobulin is working. In the case of an ELISA system the anti-immunoglobulin may be labeled with an enzyme (conjugate) which activates a substrate added to the system to give a chromogen reaction; in this case the positive control indicates whether the conjugate has reacted, and whether the substrate has worked properly as an activated chromogen. A negative control provides information about the absence of reactive antibodies specific to the particular antigens used in a test system. It also provides information as to the reaction level, determined by the signal used in a particular test, at which a specimen may be considered negative.
The cut-off point in a particular test is often based upon the relative value obtained by a positive control and/or by the negative control. An acceptable detection range obtained by the controls utilized with a particular type of test kit is specifically designed and titrated for that tYpe of kit. The positive control "value" obtained in a particular test system affects the sensitivity of that test system; the negative control "value" affects the specificity of the test system.
Presently, the antibody used for a positive control is obtained from seropositive human donors. As can be appreciated, it is disadvantageous to depend upon seropositive donors as the sole source of antibody required for a positive control. Notably, the supply of antibodies is scarce and uncertain and the quality and characteristics of the antibody varies from donor to donor. Further, as more successful therapies become known and used, fewer seropositive donors will be available, and thus the required antibody even more difficult to obtain.
In the case of AIDS patients it has been found that the condition of patients who donate blood or are subjected to plasmaphoreisis deteriorates rapidly. Therefore, obtaining AIDS positive blood or plasma from patients can accelerate the disease and accordingly, using AIDS patients as a source of antibody for use as a positive control should be avoided.
The previously mentioned assay systems detect the presence or absence of IgG (immunoglobulin G). Such assays only allow "controlled" detection (measurement defined by use of anti-IgG conjugate and of antibody positive control) of the presence of IgG in blood and body fluids directed to antigens used in the test systems. The appearance of detectable IgG directed to antigens in an infected/immunized individual does not occur until 30-40 days after initial infection in many instances. The IgG class antibodies are often present for months or years after infection/immunization.
The presence of circulating IgG directed to immunizing antigens during the course of an infection (or after immunization) is preceded by the presence of circulating IgM antibodies directed towards the antigens/immunogens. IgM antibodies directed to antigens in an infected/immunized individual are often present in detectable quantities as early as 14 days (or earlier) after the infection/immunization. The IgM class antibodies gradually lose titer 30-35 days after initial infection/immunization.
It is widely recognized that diagnostics which can detect antibodies other than IgG are desirable. For example, it is known that generally after confrontation with a foreign body, the human immune system responds by generating antibodies against the foreign body or antigen. It is believed that IgM, not IgG is produced first. As can be appreciated, assays capable of detecting IgM will facilitate early detection of numerous diseases. IgM is, however, a relatively short-lived antibody. While it may be produced shortly after infection, IgM levels fall, eventually below detectable levels, as IgG is produced, in increasing amounts. See FIG. 1 which compares the titer of IgM and IgG in a pig immunized with HIV-1. Because IgM has a short life span, IgM levels are typically below detectable levels before many diseases are even diagnosed. Therefore, IgM is not readily obtainable from seropositive donors and a dependable, reliable source of this important antibody is needed.
The present invention overcomes the previously mentioned disadvantages because it provides the ability to produce the desired antibody, i.e., IgG and IgM in a non-human species. In accordance with the present invention there is provided a method of using non-human immune antibody as a positive control in assay systems.
The present invention provides a use for non-human immune antibody in an improved assay system for detecting the presence or absence of antibody which binds with viral antigen. In an assay for detecting the presence or absence of an antibody which binds to an antigen of a human retrovirus comprising the steps of (1) sequentially contacting the antigen with a biological fluid and positive control comprising an antibody to the antigen for times and under conditions sufficient for the antigen and any antibody in the biological fluid, and the antigen and antibody in the positive control to form antigen-antibody complexes and (2) detecting the formation of the complexes, the improvement comprises the use of a positive control comprising a non-human immune antibody, the non-human immune antibody is reactive with an anti-human antibody.
It is presently preferred to use mammalian immune IgG and/or IgM and most preferably porcine immune IgG and/or IgM as a positive control in the assay.
The present invention also provides non-human immune IgM antibody and a method for producing such IgM.
It has been found, in accordance with the invention, that in both HIV-1 and in HTLV-I lysates immunized animals IgM directed to viral antigens may be detected as early as 12-15 days after immunization. IgM is still detectable 30-40 days after immunization. At that time IgG directed to the viral antigens (30-40 days after immunization) is still measurable. It is anticipated that in humans IgG antibodies directed to HIV-1 do not appear until, at the earliest, about 4 weeks after infection.
In accordance with the present invention, the non-human immune antibody is obtained by immunizing an animal with viral material against which it is desired to raise a specific antibody. Examples of suitable immunizing agents include HIV-1, HIV-2, HTLV-I, HTLV-II, CMV and Epstein-Barr Virus. Of course, other immunizing agents as may be known to those skilled in the art are also useful.
The immunization procedure begins with a first vaccination of the animal with a preparation comprising 10-500 ug of viral lysate or selected portions of the viral core or envelope proteins. The viral material is preferably solubilized in Triton X-100, SDS (sodium dodecyl sulfate), mercaptoethanol, and/or Nonidet P40 detergent, and suspended in phosphate buffered saline (PBS), pH 7.2-7.4. It is presently preferred to premix 0.1-5% Triton X-100 with the PBS to elicit an optimum immune response. The first injection contains an adjuvant; Freund's complete adjuvant is preferred for this purpose. Of course, other adjuvants known to those skilled in the art may also be used. The first vaccination typically comprises a total volume of 2 ml, one ml of viral material in buffer plus one ml of adjuvant. The viral material and adjuvant should be thoroughly mixed immediately prior to injection. In a preferred embodiment, the first vaccination contains 50-100 micrograms of viral material in 1.0 ml of PBS-Triton X-100 mixed with 1.0 ml of Freund's complete adjuvant.
Booster immunizations are generally prepared without adjuvant. These injections typically contain 10-500 ug of viral proteins, preferably from about 50-100 ug per injection in PBS, pH 7.2-7.4. The lysate can be solubilized in detergents, e.g., Triton X-100. Booster injections begin from about 7 to 30 days after the initial vaccination and every 7 to 30 days thereafter until the desired antibody titer is measured, i.e., a sufficiently high titer is indicated by an OD value at least equal to a positive control reading on an ELISA test system. For example, in the ElectroNucleonics (VIRGO) HIV-1 Antibody ELISA system an HIV-1 positive control serum has an OD value of over 0.250 and under 1.000 (at 492 nm with a 650 nm reference) measured on a Behring Processor II.
It should be understood that optimal antibody titers may vary depending upon the virus used as an antigen and the particular test system used. The IgG positive control and the IgM positive control should be capable, in a certain dilution, of producing an OD value within the OD ranges given for a positive control in the individual types of known test kits (to be determined for each type of test kit) containing viral antigens for which the positive control is to be used. For example, a nonimmunized control pig serum produces an OD value, which is under the cut-off at the same dilution at which a pig positive control serum gives an acceptable positive value (e.g., for HIV-1 A6 ELISA VIRGO ENI, between 0.25-1.100).
The antibody titer is checked periodically, typically every 14 days or just prior to administering booster injections. A first blood sample is generally drawn and tested prior to the initial vaccination to establish a baseline antibody level.
It is presently preferred to vaccinate by subcutaneous injection, but other modes of administration, such as intramuscular injection may be used. The vaccination site is preferably the side of the neck, typically injecting three to four different locations. Vaccination on the neck is considered to yield higher antibody titers, but other vaccination sites as are known to those skilled in the art are suitable for raising the desired immune antibody.
Once the desired antibody titer is measured, blood from the immunized animal is collected, either by bleeding or sacrificing the animal and collecting its blood. When raising IgM antibody, to insure sufficient high antibody titer for use as a positive control, it is preferred to sacrifice the animal and harvest its blood for separation of serum when the pig serum tested shows an OD value which is within the range of a positive control, when tested in different test systems. However, it is preferable to harvest all the pig blood when the pig serum shows maximum OD value for the particular class of immunoglobulins (IgM or IgG) when the other class of immunoglobulins is below the cut-off point.
The collected blood or serum extracted therefrom is treated before use to inactivate any live virus. It is presently preferred to photochemically treat the blood or serum with Psoralen followed by U.V. irradiation. Other methods such as gamma irradiation or heat inactivation (56� C. for one hour) may also be used. It should be understood, however, that heat inactivation may adversely affect antibody titer and may not be as effective in inactivating virus as the other methods.
It is presently preferred to use serum from the immunized animal as a positive control in an assay system. However, whole blood, plasma or any other form of antibody as may be known to those skilled in the art is also useful. Before use, it is presently preferred to filter and sterilize the blood or serum and then freeze aliquots for later use; alternatively, the serum may be freeze-dried or fractionated to enrich the IgG or IgM fractions.
The previously described method can be used to produce antibody against several viruses including HIV-1, HIV-2, HTLV-I, HTLV-II, cytomegalovirus, Epstein-Barr virus, and hepatitis B virus. It is also considered within the scope of the invention to produce antibodies against a variety of bacteria such as E. coli, Salmonella, Tetanus, Streptococcus, and Neisseria.
The following examples are considered illustrative of the present invention.
A 60 lb mixed Yorkshire breed pig was immunized (by subcutaneous injections in the left side of the neck) with 50 ug of solubilized HIV-1 antigen lysate, psoralen--U.V. irradiation inactivated, in 1 ml of PBS-Triton X-100 and 1 ml of Freund's complete adjuvant. Just prior to injection blood was drawn from an ear vein and tested for the presence of IgG and IgM antibodies to HIV-1.
Booster injections contained 50 ug of HIV-1 viral lysate in 1 ml of PBS buffer containing lysing detergents such as Triton X-100. The first booster was administered 14 days after the first immunization, and a second booster 14 days later. The pig received a total of 5 vaccinations before it was sacrificed and its blood was harvested, and the serum was used as IgG against HIV-1. Prior to each booster, ear vein blood samples were drawn (and designated Booster #1 and Booster #2, etc.) IgG and IgM antibody titers were measured.
The presence of IgG anti-HIV-1 was measured using the ENI HIV-1 ELISA VIRGO system, following the method described by the manufacturer. The IgM anti-HIV-1 was measured using a modification of the ENI system. The modification comprised substituting affinity purified goat anti-human IgM μ change specific, labelled with alkaline phosphatase (available from Calbiochem, Catalog #401902) for the anti-IgG conjugate normally used. P-Nitrophenyl phosphate tablets, prepared in accordance with the manufacturer's instructions, were used as the substrate (P-Nitrophenyl phosphate tablets are available from Bio-Rad, Catalog #172-1063). The incubation times and washing procedure were performed as directed in the ENI package insert. The results of the IgM class were read on the Behring ELISA Processor II at 405 nm with a 650 nm Reference (see FIG. 1). The test results are plotted on FIG. 1, which is a graph plotting the OD values of IgG and IgM specific anti-HIV-1 against time.
As may be seen in the drawing, IgM is detectable before IgG. IgM peaks at about day 14 and falls to below detectable levels by day 42.
Based on the antibody titer indicated by the OD value at Booster #3, the pig's blood contained an antibody titer sufficient for use as an IgG class positive control 42 days after vaccination. It is presently believed that between two and six booster injections are required to reach antibody titers in the optimal range.
A 60 lb mixed Yorkshire breed pig was immunized as described in Example 1 with 50 ug of solubilized HIV-1 antigen lysate. Five booster injections, each containing 50 ug of viral lysate, were administered every fourteen days, beginning 14 days after the first injection. Blood samples were drawn from the pig's ear vein prior to the first vaccination to obtain baseline antibody levels, and prior to administering each booster injection. The pig was sacrificed at day 60 and its blood collected. Serum was separated, sterile filtered and frozen. Upon testing the serum showed a high titer of IgG specific anti-HIV-1 (O.D. about 1.800) with IgM below detectable levels. The serum collected is thus useful as a positive control in an assay for detecting antibodies which bind with HIV-1.
The following test results were obtained:
______________________________________ Human HIV-1 Ab Positive Pig IgG Control Anti HIV-1 Cut-Off (ENI)______________________________________Baseline* 0.012-0.017 0.273 0.791Booster #1 0.103 0.250 0.650Booster #3 0.750-0.800 0.260 0.497______________________________________
IgM antibodies specific to HIV-1 were measured at Booster #3 and were found to be below cut-off (OD=0.113). Thus, IgM was below cut-off by day 42.
For purposes of this Example, IgG was measured using an HIV-1 Ab-IgG kit from ElectroNucleonics Inc. (ENI) in accordance with the manufacturer's instructions. IgM was measured using a modification of the HIV-1 ENI test kit. The IgM was measured using the method described in Example 1
A 60 lb mixed Yorkshire breed pig was immunized (by subcutaneous injections in the left side of the neck) with 100 ug of HTLV-I viral lysate solubilized with Triton X-100 in 1 ml of PBS and 1 ml of Freund's adjuvant. No booster injections were administered. Ear vein blood samples were drawn prior to vaccination, 12 days and 17 days after vaccination. The pig was sacrificed at day 17 and its blood collected. The serum was separated, filter sterilized and frozen. Upon testing the serum showed the presence of IgM specific anti-HTLV-I at a level sufficient for use as a positive control. IgG was below detectable levels.
For purposes of this example IgG was measured using an HTLV-I Ab test kit from DuPont. The anti-IgG conjugate in the DuPont Test Kit is alkaline phosphatase (the substrate is supplied with the test kit). IgM was measured using a modification of the HTLV-I DuPont Test Kit in which the anti-IgG conjugate was substituted by an anti-IgM alkaline phosphatase used at a 1:10 dilution (Calbiochem, Catalog #401902).
The following results were obtained:
______________________________________ IgM* IgG*______________________________________BaselineDay 12 1.283 0.030Day 17 2.200 0.300______________________________________ *The cutoff had an OD value of 0.522 and the IgG positive control had an OD value of 0.979.
A 60 lb mixed Yorkshire pig was vaccinated with 50 ug of HIV-1 viral lysate as previously described in Example 1. The viral lysate was purified by sucrose gradient centrifugation at approximately 100,000� g (4� C. for one hour) on an ultracentrifuge.
Blood samples were drawn prior to the first immunization 13 days and 15 days after vaccination. No booster immunizations were required. The pig was sacrificed at day 15. The blood samples collected were tested for IgG specific anti-HIV-1 proteins using an HIV-1 Antibody ELISA available from ElectroNucleonics (ENI). The blood samples were also tested for the presence of IgM using a modified ENI test kit. The modification comprised substituting affinity purified goat anti-human IgM, μ chain specific, labelled with horseradish peroxidase (available from Calbiochem, Catalog #401905) for the anti-IgG conjugate normally used. The substrate supplied with the ENI kit was used in accordance with the manufacturer's instructions. The incubation times and washing procedure were performed as directed in the ENI package insert. The results were read on a Behring ELISA processor at 492 nm with a 650 nm reference.
The results were as follows:
______________________________________ Optical Density* IgG IgM______________________________________Baseline 0.042 0.085Day 13 0.051 0.623Day 15 0.053 0.796(after sacrifice)______________________________________ *The cutoff value was OD 0.192; the IgG positive control value was OD 0.921.
The results show that the collected blood had a high IgM antibody titer but was not contaminated by IgG specific anti-HIV-1, and therefore is useful as a positive control in an assay for detecting IgM specific anti-HIV-1.
In producing porcine immune IgM specific antibody, it has been found that an antibody titer within the optimum range is obtainable within 14-40 days. It is presently believed that initial vaccination, without subsequent booster injections, is sufficient to obtain the desired result. However, it should be understood that one or more boosters may be required depending on the animal immunized. The need for any such boosters can be determined by carefully monitoring levels of both IgM and IgG. Such monitoring is also necessary to insure obtaining blood containing sufficiently high levels of IgM but undetectable levels of IgG.
While preferred embodiments of the invention have been described, it will be apparent to those of ordinary skill in the art that various changes and modifications may be made therein without departing from the spirit and scope of the invention. Accordingly, the above description should be construed as illustrative, and not in a limiting sense, the scope of the invention being defined by the following claims.
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SAN ANTONIO — Steve Nash wishes he could turn back the hands of time and have a do-over on this season. Nothing has gone right for the Los Angeles Lakers point guard.In his second game as a Laker, Nash suffered a non-displaced fracture in his left leg following a violent collision with Portland rookie Damian Lillard. It has been all downhill from there for the 16-year veteran and two-time MVP.After the Oct. 31 injury against Portland, Nash didnt return until Dec. 22 against the Golden State Warriors. Nash then injured his right hamstring March 30 against the Sacramento Kings, forcing him to miss the final eight games of the regular season. Its been a tough year, Nash said after Mondays practice at Texas Military Institute. I havent missed many games in my career, and I think whats frustrating is just how it happened.I obviously broke my leg at the start of the year and it really took me until a couple of months ago to start to figure out how I could fit into this team, and to get healthy, because youre seven weeks off and then two practices and then playing, you never quite get that feeling back. Its frustrating that I finally started to feel a place within the mix and healthy, and then this.Nash, who as a Dallas Mavericks point guard in 1998-2004 helped turn around the franchise, was only on the court for two minutes against the Kings. He didnt play again until Game 1 of the opening-round playoff series against the San Antonio Spurs this past Sunday. Nash played 29 minutes, was 6 of 15 from the field and finished with 16 points and three assists in the Lakers 91-79 loss to the Spurs.When the Lakers play the Spurs in Game 2 of this best-of-seven series Wednesday at 8:30 p.m. at the AT&T Center, Nash said he will again be in the starting lineup.Hes someone were going to have to have, Lakers coach Mike DAntoni said. Obviously he can play better.He has been the MVP twice, so weve all seen that. Were not going to do it without him.Last week Nash received some epidural injections to help alleviate a nerve issue that caused pain and a sore hip, and some weakness in his hamstring. The injuries, Nash said, never had him considering retirement.When I was healthy this year I felt pretty good, the 39-year-old Nash said. I think still, for the amount of opportunities I got on this team, I still was just as efficient as Ive always been.As far as how I felt and my ability, once I got my legs back under me after breaking my leg, I felt as good as ever and I still feel pretty optimistic Ill feel that way next year.Nash signed a three-year, $27 million contract last summer and averaged 12.7 points and 6.7 assists and 32.5 minutes in 50 games this season. The games were the fewest hes ever played in a non-lockout season.I just see him battling through some physical ailments that he has and not having the explosive stuff that he has, DAntoni said. But hes always a threat on the perimeter, hes always that shooter we have to have out there to open up space for [Dwight Howard and Pau Gasol].But for Nash to open that space, his wheels need to be solid. And right now, hes far from 100 percent.I think a lot of my problems that Im facing now had a lot of contributions from breaking my leg early and never really getting a chance to get in great shape again, Nash said. I think any time you change environments and we had a lot of guys change environments it takes time to come together.And with all the injuries that prolong that time, weve all fought and fought and fought, and have not gotten a lot of joy out of it. Thats why Im still thrilled to get a chance to play in this series, thrilled to try and fight for my teammates and to try to make something good happen out of all this.
Dwain Price, 817-390-7760 Twitter: @dwainprice


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I find myself rooting for James Mangold's Knight and Day, which functions better as a breezy summer popcorn rom-com than an action-packed chase movie, as Justin Chang of Variety points out:Read More »
As I've said, most awards shows are about people promoting themselves. Wouldn't it be a great idea to get the three stars to intro the Twilight: Eclipse video? (It's below, along with clips from the Harry Potter and the Deathly Hallows, The Last Airbender, and Scott Pilgrim vs. the World.) Let's hav...Read More »
Tom Cruise dons producer Les Grossman's hirsute fat suit once again for the MTV Movie Awards, which air on June 6. One video shows a hairy post-Scientology Cruise assaulting an older Cruise reenacting the young Risky Business Cruise. An unintentional meta-enactment of his entire career? He also da...Read More »
In Contention's Kris Tapley, refreshed after a sojourn from his labors, and I reconvene for a summer edition of Oscar Talk. We cover the lacklustre spring season, look forward to Cannes and the summer, and dissect Iron Man 2.Read More »
It's starting to look a lot like summer.Read More »
The TV spots for high-octane action comedy Knight and Day inspired me to tweet: "Knight and day with cruise and diaz looks cheesy. Even with top dollar vfx."Read More »
I am surprised by the film industry and the media's continued willingness to give a free pass to entrepreneur Carlos de Abreu's Hollywood Film Festival, a cannily constructed facade which honors stars, filmmakers and craftspeople and lines the pockets of de Abreu.Read More »
Patrick Goldstein calls around to nail down the new austerity hitting Hollywood. And Kim Masters details pay cuts for Denzel Washington and Tom Cruise, as well as how cost-cutter Disney is trying to deal with spendthrift producer Jerry Bruckheimer, the exemplar of Hollywood's old ways.Read More »
Clearly, Tom Cruise is not the mega-star he was when MGM chairman and CEO Harry Sloan gave him and then-partner Paula Wagner a piece of United Artists. Now he has the flop Lions for Lambs behind him and Bryan Singer's tarnished Valkyrie looming ahead--the film that looks like more of an expensive ar...Read More »
When Bryan Singer first approached United Artists with the idea of making Valkyrie, he wanted to do it for about $25 million. Then Tom Cruise got interested and the budget exploded. The same thing happened to Lions for Lambs -- to Cruise and Robert Redford, it seemed like a modest little movie; at $35 million plus marketing, it was still too expensive for what it was. The idea of UA being an indie was impossible with the players involved. Now Valkyrie, which several people I know have seen and liked, has bad buzz and will be judged as a costly star vehicle, which is quite different from a $25 million movie with no marquee star. Finally, MGM h...Read More »


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Welcome to Oscar Patterson Elementary School
1025 Redwood Avenue
Panama City, Florida 32401
Phone: 850-767-4675 | Fax: 850-747-5478
School Day: 7:45 a.m. to 2:30 p.m.
As Rockets, we are:
School registration and yearly updates are online and will be done through the Bay District Schools' Parent Portal. A link is provided in the section below. Please refer to the categories on the Parent Portal page, and select the option that applies to you. If you need any further assistance, please contact Oscar Patterson Elementary School @ 850-767-4675 or BDS Student Services @ 850-767-4311.
Parent Portal is a complete online system which allows the parent/guardian access to their student's information including, but not limited to, student schedules, grades, discipline, and attendance.
For the very best user experience, you will need to use FireFox or Google Chrome as your browser.
Click here for download directions. Connect with your child's school by downloading Bay District Schools mobile app. The app features a newsfeed, event calendars, contact directory, quick links, pictures, and documents.
The Bay District School Board representative for Oscar Patterson Elementary School is Mr. Joe Wayne Walker.
Thank you for visiting our site. It is not our intention to use copyrighted material without permission.
Please free to email any suggestions, comments, or corrections to the school webmaster.
The NCLB School Public Accountability Reports for recent school years are available online.
The report for 2012-13 may be accessed at the following URL: http://doeweb-prd.doe.state.fl.us/eds/nclbspar/year1213/nclb1213.cfm?dist_schl=3_291


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Photos: The best of Cowboys' wide receiver Miles Austin
Dallas Cowboys Miles Austin on stage as the receivers are introduced during the Kickoff Spectacular at the Alamodome in San Antonio, on July 23, 2010.
Photo: Vernon Bryant / Staff photographer
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2012 Update: there might be new versions of this tool called: Security Tool 2011 and Security Tool 2012.
Security Tool is a rogue antivirus application that deliberately gives reports of false system security threats on your computer and displays fake security alerts or notifications to make you think your PC is infected with malware. The misleading application is from the same family as Total security 2009 and System Security. When installed, SecurityTool will be configured to start automatically when you log on into Windows. Then it will imitate system scan and display a variety of infections that can't be removed unless you purchase the program. The files detected during the scan are either harmless or legitimate system files and can't cause any damage to your computer.
Security Tool is pushed through the use of Trojans, fake online anti-malware scanners and other malicious software. It is installed along with Trojans FakeAV that display fake security warnings and promote SecurityTool malware. Once running, the bogus program will block legit programs and especially anti-virus software. Another interesting thing is that if you click on Updates button, you will see "Updating", but actually there is no network activity. It's just another argument why Security Tool is classified as a rogue security application. ĀWhat is more, this parasite will impersonate Windows Security Center and constantly display warnings/notifications about serious security threats and privacy issues. It may claim that your computer is under attack by an Internet virus or that private data can be stolen. For example:
"Security Tool Warning
Spyware.IEMonster activity detected. This is spyware that attempts to steal passwords from Internet Explorer, Mozilla Firefox, Outlook and other programs. Click here to remove it immediately with SecurityTool."
To make things worse, SecurityTool or its 2011 and 2012 variants will hijack web browsers and block certain security websites obviously to protect itself from being deleted. It should be already obvious that this program is a scam. Do not purchase it. Instead, please use the removal guide below to remove Security Tool from your PC manually for free.
QR is short for Quick Response. They can be read quickly by the mobile phones. QR codes can store more data than
standard barcodes, including url links, geo coordinates, and text.
The reason we add QR code to the website is that parasites like Security Tool are really hard to remove on infected computer. you can quicly scan the QR code with your mobile device and have manual removal instructions to uninstall Security Tool right in your pocket.
Simply use the QR scanner and read removal instructions from mobile device.
Information added: 2009-09-25 02:00
Information updated: 2012-04-19 06:11
Attention: Use this form only if you have additional information about Security Tool parasite, its removal instructions, additional resources or behavior. By clicking "post comment" button you agree not to post any copyrighted, unlawful, harmful, threatening, abusive, harassing, defamatory, vulgar, obscene, profane, hateful, racially, ethnically or otherwise objectionable material of any kind.


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19 Oct
Official sets pick that leads to Peyton Manning touchdown pass
Like Manning needs any help.
Like Manning needs any help.
Former officiating czar Mike Pereira disagreed with the decision to eject the All-Pro linebacker.
One official seemed to move Dont'a Hightower out of an illegal formation.
The new system broke down.
Since Adam Silver took over for David Stern as NBA commissioner, one of his avowed changes has been greater transparency with the (…)
Dear NCAA tournament referees, Let 'em play. Sincerely, All of us For the second straight night, (…)
In any sport, the goal of the official is to be unnoticed and make calls without interfering with the game. On Wednesday, Mark Ayotte (…)


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Luke James - I.O.U. (Summertime Remix)
Artist: Luke James
Featuring: Wale
Producer: Danja
Album: None (Promo Single)
Avg Rating: 3.3 ( 7 votes )
Featured on our front page back in February, Luke James' I.O.U. was just the cut to warm Boothgoers' hearts during the final weeks of winter. Just as you wouldn't wear a down jacket in 90-degree weather, though, a cozy winter jam doesn't sound quite right in July. To ensure that fans can continue to enjoy the record as the mercury rises, the NARS/Def Jam crooner has crafted a Summertime Remix featuring a revamped beat and a fresh guest feature. In place of The Runners' original boardwork, Danja cooks up an airier, synth-driven backdrop for the singer's heartfelt expressions of romantic devotion. Fresh off last week's release of his junior set, MMG representative Wale contributes a confident closing 16. This promotional cut isn't attached to a larger project, but we in the Booth will keep you posted on Luke James' plans as the summer progresses.
Written by richard on 07/1/13
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"I Want You" (2012)
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No. 1 Alabama steamrolls Arkansas
TUSCALOOSA, Ala. (AP) — AJ McCarron threw three touchdown passes and Kenyan Drake rushed for 104 yards and two scores to lead No. 1 Alabama to a 52-0 victory over Arkansas on Saturday night.
The Crimson Tide (7-0, 4-0 Southeastern Conference) rolled to a 28-0 halftime lead and e...
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The basis for a great incentive travel program is this: Give your qualifiers a fantastic experience to brag about when they get back — and make sure it's an experience that they could never buy off the shelf. That might sound like a tall order, but one way some companies are guaranteeing an inimitable event is by taking over an entire resort and making themselves at home. Anyone can buy a beautiful guest room in a posh property, but few people have arrived on-site to find their company logo ...
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Media Releases
Geoscience Australia awarded for innovation in community resilience24 November 2014
Minister for Industry Ian Macfarlane has congratulated Geoscience Australia on being recognised for its work in strengthening community disaster resilience at the annual Resilient Australia Awards ceremony held today at the Australian War Memorial in Canberra.
Australia's vocational education and training stars recognised at national awards21 November 2014
Australia's leading vocational education and training students, teachers and institutions have been recognised at the 2014 Australian Training Awards held at the Adelaide Convention Centre tonight.
Australia to host Ministerial Meeting of the Forum for Nuclear Cooperation in Asia18 November 2014
Australia will host the 15th Ministerial Level Meeting of the Forum for Nuclear Cooperation in Asia (FNCA) for the first time, reaffirming the nation's position as a global leader in nuclear non-proliferation.
Skills and training reforms support growing numbers of apprentices and trainees13 November 2014
Industry Minister Ian Macfarlane welcomed new figures today which show the number of people starting trade and non-trade apprenticeships and traineeships increasing for the first time in over a year.
Labor shatters bipartisanship by walking away from RET12 November 2014
The Labor Party has shattered more than a decade of bipartisanship on the Renewable Energy Target (RET) and walked away from playing any constructive role in putting the Australian renewable energy industry on a long-term sustainable footing.
Australian astronomers' stellar result at star-studded awards11 November 2014
Industry Minister Ian Macfarlane has congratulated two international teams of astronomers, including several from Australia, who have received global recognition for their research through a prestigious science prize.
Minister leads Australia's largest skills delegation to India10 November 2014
Australian Industry Minister Ian Macfarlane is leading the largest ever Australian skills delegation to India to encourage greater collaboration between the two nations.
Greater skills collaboration with South Korea7 November 2014
The Australian Government is laying the foundation for greater skills and training collaboration with South Korea, with the signing of a Memorandum of Understanding today.
Bill Shorten and Mark Butler run separate energy policies7 November 2014
Leader of the Opposition Bill Shorten today contradicted his own Labor colleague and Environment spokesperson Mark Butler on energy policy, mustering at best mixed messages about the future of coal and the jobs its supports.
Labor turns its back on Australian workers by supporting the end of coal in Australia5 November 2014
The Labor Party has turned its back on tens of thousands of Australian coal workers and undermined regional communities across the country, with the Shadow Minister for Environment today admitting


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Wanna know what members of the style team are adding to their wardrobes this season? Take a look – then shop the goods!
Credit: Courtesy Shopbop.com
Updated: Wednesday Sep 03, 2014 | 01:00 PM EDT
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Loni Venti, Style & Beauty Editor: Just big enough to hold my weekend essentials (in other words, lipstick, credit cards, iPhone), plus it's got a fun candy apple shade that will add a playful pop of color when I'm otherwise in head-to-toe fall neutrals. I've already decided it's going to be my go-to Sunday Funday bag.
Buy it! Furla "Candy" mini cross-body bag shopbop.com, $148
Copyright © 2014 Time Inc. All rights reserved. Reproduction in whole or in part without permission is prohibited.


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If you ever raced Saddleback on a big day, then you know how far you could jump down the four-story Banzai Hill. Now imagine how far you could jump if you were Danny Magoo Chandler. Jody Weisel shot this photo of Magoo, on a 1981 Yamaha YZ125, glancing over to see Chappy Blose bite it at the bottom on Banzai.
We found him because he left digital breadcrumbs all over Spain
Come to Glen Helen next week and honor Kurt's
Better known around these parts as mud
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Category Archives: mma
The Ultimate Fighter 20, Episode 9: Mean girls
It's been a while, hasn't it? The last season of The Ultimate Fighter I recapped in full was Season 16. Remember Shane Carwin? But I'm inspired. Season 20 — all women, all contenders, a title belt on the line — is terr...
Posted in mma Tagged felice herrig, randa markos, the ultimate fighter, tuf 20, ufc 2 Comments
Unsolicited advice for the UFC
When a UFC fight card coincides with a Bellator fight card, the choice should be obvious. And yet it's not. The UFC has the talent — by my quick count, 83 of the 90 top-10 fighters in the Sherdog rankings. At … Continue reading &r...
Posted in mma Tagged bellator, the ultimate fighter, ufc, ufc 180 Leave a comment
Art Davie, The Ultimate Fighter and the changing face of the UFC
Female fighters have taken the spotlight in the UFC. And I haven't heard anyone complaining. (Please don't dig up some misogynist troll on Twitter — I'm sure they're out there, but they don't deserve any attention...
Posted in mma Leave a comment
I'm back – what'd I miss?
My hand is out of a splint after three weeks, though my typing speed is still diminished by a bit of tape on my two still-aching fingers. I may need to put my goalkeeping career on hold for a while. … Continue reading →...
Posted in chess, mma, olympic sports, soccer Tagged badminton, equestrian, judo, modern pentathlon, rowing, swimming, track and field, triathlon 1 Comment
MMA's new Dark Ages
Why limit five-on-five to basketball? Why limit fighting to one-on-one? Most people could come up with a whole list of reasons, but that hasn't stopped Team Fighting Championship from lining up five-man teams to do battle in the … well, &...
Posted in mma Tagged team fighting championship Leave a comment
Monday Myriad, Aug. 4: Flip and fight
Starting with a few bits of news: – Both U.S. teams won their first matches at the 2014 Chess Olympiad, then faltered today against high seeds. The U.S. open team lost 2.5-1.5 to the Netherlands, while the U.S. women lost … Continue read...
Posted in chess, mma, olympic sports, winter sports Tagged gymnastics, jon jones Leave a comment
Monday Myriad, July 28: Sprinter's paradise
We begin this week with a view of a cycling sprint finish from the winner's perspective. Sounds like that would be "nothing," but Marianne Vos didn't take the lead until the last few meters: Last 200m is strangely zen. RT &hel...
Posted in cycling, mma, olympic sports, track and field Tagged boxing, commonwealth games, lawn bowls, wrestling Leave a comment
MMA has answered its fundamental question
UFC founding father Art Davis has written a book (with fellow soccer/MMA commentator Sean Wheelock) on the early days of the UFC — Is This Legal?: The Inside Story of The First UFC from the Man Who Created It. Bloody … Continue reading &...
Posted in mma Tagged art davie, ufc Leave a comment