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Hasbro unveils 2013 spring games
Hasbro Games
Hasbro owns some of the biggest brands in the game world. That gives it the ability to draw upon popular themes and exciting characters that people recognize and enjoy when producing a new board game. It also partners with other great companies to license some of the hottest toys and games that kids want to play.
Four new games introduce some new themes and revisit some old favorites in a new way. Take a look:
Bejeweled! $20, 2 to 4 players
Based on a popular computer game, Bejeweled requires players to slide various colored gems around the board to create a row of three or more matches. When a matching row is created, remove the gems and score a coin of the same color. Replace the gems randomly and try to create more matches. Earn three coins of the same color and you win. This game is pure eye candy with sparkly colorful gems. My 10-year-old daughter loves this game and plays it often with her friends. Hasbro did a great job of creating a playable board game based off of a computer game.
The Game of Monopoly Hotels, $25, for 2 players
This version of Monopoly is extremely different. Two players go head to head trying to build five floors of a hotel. Each level can hold a card that details what kind of room it is and how much rent it produces. For example, you can build a beach, aquarium or race car room, just to name a few. But watch out because your opponent will try to sabotage your hotel by playing bill cards that bring in rats, floods and dirty laundry. You can protect your hotel floors by inviting celebrities to live there. It's fast-paced and fun with tough decisions about what cards to play. Do you protect yourself, build a new floor, sabotage your opponent or collect more cash? The choice is yours.
World Series of Yahtzee, $20, 2 to 4 players
One of things about traditional Yahtzee that slows the game down is waiting for your turn, but not with this new edition. All players play at the same time with a different set of cool, custom dice. An electronic buzzer sits in the middle of the board surrounded by cards with a certain dice combination and point value. Yahtzee, a set of five of the same numbers, is worth 50 points, and the point values go down from there for straights, three of a kinds and a full house. To begin, someone calls out "start" and players begin rolling dice frantically to match one of the cards on display. As soon as a player has a match, he or she punches the timer in the middle. The remaining players have only a few seconds to buzz in and lock in their points. Collect your cards, replace them with new ones and start again. When all the cards run out, the highest score wins. And did I mention the cool, custom dice?
Angry Birds Star Wars Millenium Falcon bounce game, $20, 1 or more players
One of the coolest ships in the galaxy by far is the Millenium Falcon. Unlike previous versions of Star Wars Angry Birds, where you try to launch a bird at a structure to destroy it, the goal here is to bounce a Star Wars character ping pong ball into one of the open holes in the ship. If you can knock down any enemies in your way at the same time, you score more points. If you can bounce the ball just perfectly into the right hole, it will roll down into the cockpit of the Millenium Falcon for maximum points. Even young kids can join in with their parents and have a good time. It's a simple game but challenging.
Ryan Morgenegg is a multimedia specialist for the Deseret News.
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I gave you the benefit of the doubt
By categorizing it as an "implication." Thanks for making yourself clear.
Now, have you forgotten how many times you've said we should work WITHIN the GOP, in order to grow the liberty movement by educating people there? If that's not building coalitions, what is? Maybe it's not the terminology you used, but it's how I understood it. If you saying that that's the best way to do things isn't "advice," then neither is Rands Iceland comment.
I'm not going into your Zionism debate. My comment had nothing to do with that... it was directed at your statement of "fact" that anyone who disagrees with your view of Snowden "HATES AMERICA."
That's a pretty ridiculous thing to say. One could (rightly) argue that they support Snowden because they want to see this country restored to what our founders envisioned, and to do so, people need to know what's happening behind the scenes. That REQUIRES people like Snowden. Our founders said it was the duty of EVERY patriot to expose those things. That's not the motives of someone who hates this country. Quite the opposite. YOUR way is not the only way of doing things. Just because someone chooses a different method, doesn't mean they have a different motive.
Ron Paul convert from the Heart of Dixie
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thank you "mad as hell" in jokes and jockettes under the down-under sun are dying in newspapers... long live online angry colours and lines ! 2 hours 51 min ago
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them polar bears again... in ice depleted at an astonishing rate of 120 cubic miles each year... 8 hours 3 min ago
but he might still pull the trigger nonetheless... in an idiot playing a game far worse than russian roulette with your life... 8 hours 10 min ago
the chimp in our armour... in jokes and jockettes under the down-under sun are dying in newspapers... long live online angry colours and lines ! 9 hours 29 min ago
substandard bunch of barnacles in the minister should be keelhauled then sacked... 9 hours 33 min ago
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Optoma PK301 LED Projector Review
The menu system for the PK301 was pretty straightforward and very graphical based. I would recommend taking a moment to glance over the manual to really get the hang of all the features. Not all the functions are obvious when you first start to dig deeper into different areas of the system.
Remote Control
Unlike most Pico projectors, the Optoma PK301 has a remote. Considering how close to the projector the user has to generally be to produce an effective presentation, it is nice to have a remote, but I do not feel it provides all that much value to the projector.
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Save to My Recipes
Muddled Cherry Syrup
Published: June 2011 Servings: Makes 3 cups time: 35 minutes time: 35 minutes
- 1 pound fresh cherries, stemmed and pitted, or frozen pitted cherries, thawed, undrained
- 1 cup sugar
Nutritional Information
Makes 3 cups, 1 tablespoon contains:
- Calories (kcal) 21.6
- %Calories from Fat 0.0
- Fat (g) 0.0
- Saturated Fat (g) 0.0
- Cholesterol (mg) 0
- Carbohydrates (g) 5.6
- Dietary Fiber (g) 0.2
- Total Sugars (g) 5.3
- Net Carbs (g) 5.4
- Protein (g) 0.1
- Sodium (mg) 0.0
PREPARATIONView Step-by-Step Directions
Using a muddler or potato masher, smash cherries and sugar in a medium bowl to release juices (it's okay to leave some cherries whole). Stir in 3/4 cup hot water. Let stand until slightly cooled, stirring occasionally, about 30 minutes. Cover and chill. DO AHEAD Can be made 1 week ahead. Keep chilled.
Strain syrup before using, reserving cherries for garnish.
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Advice from the Bon Appétit Test Kitchen
Take the Adventure Path
Camping and picnic food don't need to consist of dried-out potatoes and store-bought macaroni salad. Make dining al fresco fresh again
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From a food truck to a "pastry luncheonette," these are the Best New Restaurants in America


text: Kanye West: Celebrities Treated Like Blacks in 1960s Print article Send a Tip by Christian Toto 21 Jul 2014 post a comment The most jaw-dropping comments from Kanye West's just-released interview with GQ Magazine wasn't that he confirmed giving a 45-minute toast to himself on his wedding day. West, who lives to poke and provoke pop culture, compared being a celebrity in 2014 to what it felt like for black Americans during the 1960s. The rapper repeated the charge during the magazine Q&A. And what I talked about in it was the idea of celebrity, and celebrities being treated like blacks were in the Sixties, having no rights, and the fact that people can slander your name," he said. "I said that in the toast. And I had to say this in a position where I, from the art world, am marrying Kim. And how we're going to fight to raise the respect level for celebrities so that my daughter can live a more normal life. She didn't choose to be a celebrity. But she is. So I'm going to fight to make sure she has a better life.


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First name content excerpted from The Complete Idiot's Guide to 30,000 Baby Names © 2005 by
Marcia Layton Turner.
this book online or call 1-800-253-6476.
Last name content copyright © 2006 Patrick Hanks.
First name origin & meaning:
Latin: Horn; feminine form of Cornelius
First name variations: Cornell, Cornel, Corneelija, Cornela, Cornelija, Cornelya, Corelie, Cornella, Cornelle, Cornie, Korneelia, Korneelya, Kornelia, Kornelija, Kornelya, Neel, Neely, Nela, Nelia, Nell, Nella, Nellie, Nelly, Neal, Cornelia
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Pirates, Grilli agree to two-year deal
The Pittsburgh Pirates have agreed to bring back free-agent relief pitcher Jason Grilli on a two…
Every week, Fantasy Football Expert Rusty Reeves predicts a heaping handful of players who will decline in the coming weeks. They should be downgraded at least one tier. Chicago Bears QB Jay Cutler …Read More
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The story of the first Thanksgiving is filled with folklore and legend. But what's the real story? Here are 10 commonly believed myths about the First Thanksgiving debunked.Read More
The Pittsburgh Pirates have agreed to bring back free-agent relief pitcher Jason Grilli on a two…


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Pretty Pirate Light Up
Pretty Pirate Costume
Who said a pirate had to have a peg leg and eye patch? In the Pretty Pirate Costume you'll rule the high seas in style. This black and pink dress has a punky twist with a skull print on the skirt, but the pink bow details and head scarf will confirm your status as queen of the ship.
Twinkle Pretty Witch Child Costume
Spellbind and sparkle as you trick or treat from street to street in the Twinkle Pretty Witch Child Costume! You'll brew up something sweet in this twinkling dress which features magical green lights in the skirt that ensure this costume is an attention grabber. The long sleeves and high collar…
Pretty Pirate Captain Girls Costume
Set sail for a Halloween adventure in this classic Pretty Pirate Captain girls costume. The 100% polyester garment is complete with black, white and red, waistcoat style dress with lace underskirt and black bow. You'll be ready to take the helm at any party in this cute outfit.
Light-up Pirate Large Portrait
Their eyes will light up at the sight of this frightful ghost Pirate portrait - it features a collage-like image of ship rigging, haunted souls and a skeleton pirate. Best of all, the Pirate and his henchmen have eyes that light up in a most ghostly fashion. Great Halloween decor!
Light-up Pirate Portrait
Their eyes will light up at the sight of this frightful ghost Pirate portrait - it features a collage-like image of ship rigging, haunted souls and a skeleton pirate. Best of all, the eyes light up in a most ghostly fashion. Great Halloween decor!
Pretty Lil Pony Baby Costume
Dress your little foal up in purple and pink in this Pretty Lil Pony Baby Costume! Pink velvety bodysuit with polka-dot belly and purple horse shoe hooves are cute and comfy. Horsie headpiece includes mane, nose and ears transforming your little one into a whole new species of cute.
Pretty Paratrooper Adult Womens Costume
Everyone will salute you wearing this Pretty Paratrooper Adult Women's Costume. Form fitting camo bodysuit with zip up chest gives you the chance to show some skin while harness straps you in. You're tougher than the boys - and sexier!
Pretty Playing Card Adult Womens Costume
Play your cards right and everyone gets lucky when you wear this Pretty Playing Card adult womens costume. The red and black halter dress features a black off-the-shoulder peasant top and a red and white lace-up bodice, complete with a festive white neck ruff.
Cool Pirate Adult Mens Costume
Capture all the treasure and all the pretty ladies when you don this classic character costume - the adult men's Cool Pirate costume is roguishly handsome and richly detailed, from the swashbuckling red sash to the lace-up sexy poets shirt. Take what you want and steal hearts in the process!
Sassy Pirate Womens Costume
Sail seamlessly into any man's heart in the Sassy Pirate Women's Costume. This red and white striped dress features a black mid coat overlay. red ribbon lace-up front and a sexy, white off the shoulder top portion.
Posh Pirate Child Costume
Walk the plank in perfect style this Halloween in the Posh Pirate Child Costume. If she loves adventuring this lace-up ruffled white top has an attached vest, red and black striped leggings and matching red head tie, for all her sailing needs.
Pirate Skull Backpack
Gear up for months at sea when you add this Pirate Skull Backpack to your already fabulous pirate costume. Every sea-worthy chap should have a bag like this one with swords!
Rustic Pirate Mens Costume
Ahoy, Matey! The Rustic Pirate Men's Costume will have you sailing above the rest this Halloween. Features a long-sleeved lace-up front shirt with a faux leather vest and chest belt, obtaining any treasure will be no issue for you.
Pirate Makeup Kit
Make Up Tips Arrgh matey, what are ye lookin' at? They'll all be looking at you when you create a realistic pirate, rogue or rascal using this Pirate Horror Character Kit which includes skull shaped fake teeth. Fantastic!
Punk Pirate Child Costume
Pirates are already on the wrong side of the law, so why not add some punk? This pink and black Punk Pirate child costume isa new twist on a classic outfit. The 100% polyester garment comes complete with lace-up bodice, puffy sleeves, waist sash and black pirate hat.
Inflatable Pirate Chest Cooler
Arrgh matey! Stock up on plenty of beverages for the party and keep 'em close at hand and mighty cold in this inflatable Pirate Chest cooler. Use it indoors or out!
Pretty Pigtail Wig
Permeate your beauty with the Pretty Pigtail Wig. This hip hair style will enhance any costume with it's dark color and dual braided pigtails.
Pretty Peacock Girls Costume
Flock above the rest in the Pretty Peacock Girls Costume. Prance around as a vibrantly, stunning peacock in this jewel toned purple and blue dress with sheer tail, elaborate collar and feathered headpiece.
Pretty Kitty Gloves
Who wants to play cat and mouse? All the fellows will want in when you create or complete your costume with these super-cute black and pink Pretty Kitty gloves.
Girly Pirate Eye Makeup Kit
Capture all the treasure when you add this wicked sexy Girly Pirate Eye Makeup to your pretty pirate costume - the guys will sign on for any adventure you choose to lead!
Red Pirate Adult Womens Costume
Suit up for some swashbuckling fun when you wear this Red Pirate adult womens costume. The fancy white dress of this womens pirate costume features a peasant top, bell sleeves, an attached vest and gold lace-up bodice, complete with a classic tricorne hat.
High Seas Pirate Womens Costume
Sink hearts and rock the boat in the High Seas Pirate Women's Costume. People will be handing you their treasure when you wear this stripped dress with lace-up front and matching headscarf.
Pirate Caribbean Adult Mens Costume
Order the captain himself to walk the plank in this argghsome Pirate Caribbean Adult Mens Costume! This classic character ensemble suits you up to sail the Seven Seas in style, with its white pirate shirt, full-length brown coat with tattered trim, swashbucklin' sash, and black bandanna.
Pirate Maiden Adult Womens Costume
Sail the seven seas or work the dance floor at several parties in this Pirate Maiden adult womens costume. You'll be the treasure of the room in this striped dress and matching headscarf, complete with attached corset-style vest with lace-up front.


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Arizona State Sun Devils
ESPN.com: ASU recruiting class earns C+
By the end of signing day, the Arizona State Sun Devils experienced positives and negatives with coach Todd Graham's first full recruiting class.
On one end, the Sun Devils lost their top recruit in four-star Georgia quarterback Joshua Dobbs, resulting in a quarterback-less recruiting class.
On the other end, Graham brought in 29 total recruits -- 10 junior college transfers, one D-I transfer and 18 high school graduates -- stretching from Florida to Pennsylvania to California.
After all letters of intent were filed away, in an ESPN Insider piece, Recruiting Nation ranked ASU at No. 8 in the Pac-12 with a C+ grade.
Breakdown: The Sun Devils have done a good job at the juco level with this class. They signed their top overall commit out of the junior college ranks, defensive tackle Marcus Hardison, and wide receiver teammates Jaelen Strong and Joe Morris. As for prep products, the Sun Devils did well in California, getting signatures from four-star defensive end Garrett Marino and twin linebackers Viliami and A.J. Latu..
With the loss of Dobbs, JUCO defensive tackle transfer Marcus Hardison headlines the 2013 Sun Devil signees. ESPN.com's No. 5 junior college recruit had 26 other offers away from Tempe, including Texas A&M, Oklahoma and Florida State. Recruiting Nation states Hardison should make an immediate impact on the line with his disruptive presence up front, giving Graham another weapon next to the 2012 Pac-12 Defensive Player of the Year, Will Sutton.
Most Popular
Sun Devils Audio
- Rich Rodriguez, Arizona Head CoachWildcats head coach Rich Rodriguez previews the Friday afternoon showdown with Arizona State.
- Todd Graham, ASU head coach ASU head coach Todd Graham says his team has bounced back during practice this week.
- Ray Anderson, ASU athletic directorASU athletic director Ray Anderson discusses the announced Division I men's hockey program.
- Doug Haller, azcentral sports ASU beat writerASU beat writer Doug Haller discusses last week's loss to Oregon State.
- Mark May, ESPN college football analyst ESPN college football analyst Mark May says ASU looked too far forward after the Notre Dame win.


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Brassfield's Mom!'s Mom Answers Activity
How do you show your child love?
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Being a full time working mom I feel a lot of time is missed w/ my 2.5 month old son...as soon as I get him in my arms im telling him I l...posted by laurena143
How do you pick a baby name when your partner says he hates everything you pick?
posted by Brassfield's Mom! 06/04/2011


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64, Crosby, TXLooking for someone to share intererests and would like to share more information later. I enjoy my work and try to instill the joy of learning and the pusuit of science and t...
22, Crosby, TXMy name is Shelby. I am apart of a big family that is Catholic on both sides. We go to mass every week together and are all involved in our faith practice.I work as a waitress...
40, Crosby, TXOccupation: Banking / Financial Services / Real Estate; Height: 5' 2"; Eye Color: Brown; Hair Color: Brown; &...
57, Crosby, TXI am a professional woman devoted to my Catholic faith and large family. Although many of my children are grown and are semi-self sufficient, my home remains the favorite gath...
26, Crosby, TXHello everyone, I am so passionate about my relationship with Christ and I would love to meet a man who feels the same way. In my leisure time, I enjoy feeding ducks and going...
67, Huffman, TXFaith and family are very important parts of my life. I am retired now which allows me to spend more time with my grandchildren and more time enjoying my hobbies. I love garde...
28, Houston, TXI am a nerdy, quirky, silly, sassy, family-oriented, fun-loving Catholic beast-mode ninja, depending on the day of the week. I would love to leave it at that, but etiquette d...
53, Channelview, TXOccupation: Education / Teacher / Academic Research; Height: 5' 5"; Eye Color: Brown; Hair Color: Black; &nbs...
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45, Houston, TXI like to knit,do extersize, going to zumba fitness, and every day i go walking for one hour, also on my free time i like to spend time with my nieces and nephews
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Computer hacking can happen — just ask Burger King or Jeep. On the heels of the brands' Twitter accounts take over, a South Florida company said there are steps consumers can take to be vigilant of their online accounts and guard themselves against any potential intrusion.
One of the simplest ways to prevent hacking is to avoid logging into a public computer, said George Otte, owner of Geeks on Site, a company providing computer repair and support throughout South Florida and nationwide. Even if you log out, your usernames and passwords could be retrieved by hackers using a Keylogger software that retrieves data of every keystroke entered, he said.


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Just in the Flisvos Kitecenter the nice Kite-Café with its famous italian cuisine is located.
It offers you a tasty range out of salads, pasta, sandwiches, fruit juices, cocktails and milk shakes.
The Kite-Café has a marvellous view over the spot........ and in the evening to the sunset.
The Kite Café is open in the evening as bar and is the meeting point for all Kiters.


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November 27, 2014
This week's A+ Athlete is Taylor Reed of Denison High School. Taylor plays basketball and volleyball for the Lady Jackets. Considered a leader on both teams, she credits her drive and ambition to playing sports.
Taylor is also a standout in the classroom. She ranked 8th in her class with a 4.58 GPA. She is on the honor roll, and she's a member of national honors society. Taylor has never missed a day of school from K-12.
Taylor spends what little spare time she has working with various charities. She is involved with special olympics, habitat for humanity, meals on wheels, and relay for life.
We'll introduce you to another A+ Athlete every Friday here on First News AM. School officials, coaches, teachers, and counselors are encouraged to send in your nominees.
A+ Athletes…
--must be a senior..
--must be nominated through the student's school district- not a parent.
A+ Athlete
Friday Mornings First News AM
Fax Nominations: 903-892-4623
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- Also arrived today... Kodak 360* action cam, Zeal HD2 ski goggles, Sony Smartwatch3, and Velocomputer sensors. http://t.co/kuDpsCX0Ws #, Nov 21
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In Depth Product Reviews
You probably stumbled upon here looking for a review of a sports gadget. If you're trying to decide which unit to buy – check out my in-depth reviews section. Some reviews are over 60 pages long when printed out, with hundreds of photos! I aim to leave no stone unturned.
Read My GPS Recommendations.
Here's my most recent gadget recommendations guide (Summer 2014 edition) – covering almost every category of sports gadgets out there. Looking for the equipment I use day to day? I also just put together my complete 2013 'Gear I Use' equipment list, from swim to bike to run and everything in between (plus a few extra things). And to compliment that, here's The Girl's (my wife's) list. Enjoy, and thanks for stopping by!
Understand technology and sport in the How-To Guides.
I enjoy explaining new things to folks – especially showing people how to get the most from their gadgets. Here's an ongoing list of "How to" guides.
Read my Top 25 most useful posts.
It turns our I've written a fair bit of stuff over the past few years – and after it disappears from my front page, a lot of it never really sees the light of day again without Google'ing skillz. Or a photographic memory…which I don't have. I've taken a look back and found stuff that…continues to find a trickle of readers via web searches or forum links.
Have some fun in the travel section.
I travel a fair bit, both for work and for fun. Here's a bunch of random trip reports and daily trip-logs that I've put together and posted. I've sorted it all by world geography, in an attempt to make it easy to figure out where I've been.
Tag Archives: Bike Rack
Two quick items of note: Looking for a good vertical bike stand, and Motoactv slashes price $100
Before we get onto the new Alpha watch post here in a few hours, I've got two quick items worthy of a separate call out. First item of note: First is that I've (well, we've) decided we need a vertical … Read More Here


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Welcome to the 2014- 2015 School Year
Dear Parkdale High School Students and Parent(s) and Guardian(s):
Welcome to a new and exciting school year!
I hope your summer was filled with opportunities to reflect, learn, and
grow. This school year will bring on new
opportunities as well as challenges.
Nevertheless, we will focus on being a Great School, located in a Great Community, servicing Great Families.
Our focus has helped us shape our new school mantra – Greatness, Nothing Less!
The staff is thrilled
that you have entrusted us with your children's education. We will make every
effort to create an environment which is engaging, supportive, and
collaborative. Our goal is to help your
child achieve academically as well as socially.
Of course, we need and welcome your support and cooperation. You play a
key role in the academic success of our students; therefore, school/parent
communication is crucial.
We are dedicated to
fostering a safe, orderly, and nurturing environment with high expectations for
all students. We are committed to doing our part in ensuring your child
achieves academic excellence; and we look forward to working with you to
guarantee that our goal is achieved.
As the leader of Parkdale
High School, I strongly believe that every child can learn and achieve the
highest level of academic success with the proper preparation and support. To
ensure a successful school year please:
Ensure your child has the school uniform. We are a mandatory uniform
WORN EVERY DAY BEGINNING WITH THE FIRST DAY OF SCHOOL. All sweaters and jackets must comply with the
uniform expectation. No multicolored
sweaters and jackets.
We will continue to offer
classroom and school-based intervention strategies and support services for all
students who need them. Our instructional program
will be far more effective with your active participation. Your presence
is not only welcomed, but it is greatly needed!
Below you will find key information about the start of the school year. My staff and I look forward to working with
each and every one of you. Together, We
Will Achieve Greatness – Nothing Less!
Tanya L. Washington, Principal
Maryland's Report CardCheck here for Parkdale's Report Card to see how Parkdale did!
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Save the Date November 26 - 28 - Thanksgiving Holidays (Schools and offices closed)
December 2 - 11th grade Parent Meeting 6pm in the Senior Lounge. Get information on how to encourage literacy at home, Testing (HSA/PARCC), Credit recovery, Graduation requirements, and SchoolMax.
December 10 - 2-hour early dismissal for students
December 19 - 2nd Quarter Progress Reports Released
December 22 - January 2 - Winter Break
January 19 - Schools and offices closed
January 26 - Schools closed for students
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Vision StatementParkdale High School, a diverse community of learners, provides well developed programs and learning experiences to increase the academic achievement and personal and social development which integrates the arts, technology, communication, and the core academic areas.
Parkdale High School, a diverse community of learners, provides well developed programs and learning experiences to increase the academic achievement and personal and social development which integrates the arts, technology, communication, and the core academic areas.
Parkdale High School fosters a safe, orderly and productive learning environment that stimulates and supports students that communicate effectively, think critically, solve problems and are technologically adaptive to a constantly changing world.
Parkdale High School, in partnership with the community, parents, and other stakeholders, through curricular and extra-curricular activities consistent with the Core Standards of Excellence ensures that students become responsible and accountable individuals committed to serving the wider community with honesty and integrity.
The Productive and Honorable Students of Parkdale High will be graduated in four years, college and career ready, and possess the skills necessary to make them life-long learners and valuable contributors in our technological and global society.


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Conflict of interest: None
Involvement of Pro-Nociceptive 5-HT2A Receptor in the Pathogenesis of Medication-Overuse Headache
Article first published online: 21 DEC 2009
DOI: 10.1111/j.1526-4610.2009.01591.x
© 2009 the Authors. Journal compilation © 2009 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 50, Issue 2, pages 185–197, February 2010
Additional Information
How to Cite
Supornsilpchai, W., Le Grand, S. M. and Srikiatkhachorn, A. (2010), Involvement of Pro-Nociceptive 5-HT2A Receptor in the Pathogenesis of Medication-Overuse Headache. Headache: The Journal of Head and Face Pain, 50: 185–197. doi: 10.1111/j.1526-4610.2009.01591.x
Publication History
- Issue published online: 24 JAN 2010
- Article first published online: 21 DEC 2009
- Accepted for publication October 29, 2009.
- Abstract
- Article
- References
- Cited By
- 5-HT2A receptor;
- cortical spreading depression;
- medication-overuse headache;
- paracetamol;
- Fos;
- trigeminal nociception
(Headache 2010;50:185-197)
Objectives.— To determine the involvement of 5-HT2A (5-HT2A) receptor in the process of trigeminal plasticity induced by chronic analgesic exposure and in the process of inflammatory-induced thermal hyperalgesia.
Background.— Derangement in 5-HT2A serotonin receptor has been reported to implicate in pathogenesis of medication-overuse headache. No clear explanation concerning the precise roles of these receptors in the process.
Methods.— Wistar rats were daily administered with paracetamol (200 mg/kg) for 30 days. On the next day, ketanserin, a 5-HT2A antagonist, or saline was given prior to cortical spreading depression (CSD) induction. Electrocorticogram, cortical blood flow, Fos and 5-HT2A-immunoreactivity in cortex and trigeminal pathway were studied. In the other experiment, complete Freund's adjuvant was injected into the rat hind paw to induce tissue inflammation. Three days later, ketanserin was given and noxious heat was applied to both inflamed and noninflamed paws. The response between 2 sides was compared by measuring paw withdrawal latency.
Results.— Chronic paracetamol exposure led to an increase in CSD frequency and CSD-evoked Fos expression in cerebral cortex indicating the increase in neuronal excitability. Prolonged medication exposure also facilitated trigeminal nociception as evident by an increase in CSD-evoked Fos expression in trigeminal nucleus caudalis. The expression of 5-HT2A receptor in cerebral cortex and trigeminal ganglia was enhanced by chronic paracetamol administration. Pretreatment with ketanserin significantly attenuated these effects. The second experiment showed that ketanserin was able to lengthen the paw withdrawal latency in the inflamed side but did not alter nociceptive response in the noninflamed side.
Conclusion.— These findings suggest that up-regulation of pro-nociceptive 5-HT2A receptor is an important step in the process of cortical hyper-excitation and nociceptive facilitation induced by chronic analgesic exposure.


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Place GI Position Listings and Activity Announcements
For as little as $82.50, you can place a classified ad in AGA's weekly email newsletter, AGA eDigest, or AGA's bi-monthly magazine, AGA Perspectives. If you place ads in both AGA Perspectives and AGA eDigest, you will receive a 10 percent discount. Advertising in either includes a free online classified listing. Learn more.
Looking for flexibility and supplemental income? Our mobile endoscopy practice is seeking board-certified gastroenterologists in Northern California (Sacramento/Stockton/Tracy) and Central California (Fresno/Tulare/San Luis Obispo)! Flexible schedules allow you to work as many as 1-2 days per week or as few as 1-2 days per month. Position offers competitive pay. Join our exciting mobile team by contacting Amy Fasti at email@example.com or toll free at 877-613-3494.
Santa Clara Valley Medical Center (SCVMC), a public teaching hospital, affiliated with the Stanford University School of Medicine, located in the heart of Silicon Valley in San Jose, CA is seeking a BC/BE gastroenterologist to join our dynamic, growing, and nurturing Division of Gastroenterology and Hepatology. The successful candidate will be interested in joining a practice committed to excellence in patient care, clinical operations, patient experience, and teaching the residents and GI fellows who rotate through our service. Candidates should submit a letter of intent and CV to firstname.lastname@example.com. SCVMC is an Equal Opportunity employer.
Our medical group is seeking to add another partner to our practice. We are located in San Luis Obispo County, California, a coastal community near Pismo Beach, Avila Beach, and Paso Robles. The area has a moderate climate, offers a unique array of outdoor/ cultural activities, and is recognized as a premier wine growing area in the country.
We are interested in a gastroenterologist with excellent endoscopic/clinical skills, proficiency in ERCP, and development of a EUS capability is being considered. Please mail CV to CCGMG, Attn: Dr. Vance Rodgers, 1551 Bishop Street, Suite 230, San Luis Obispo, CA 93401.
The Division of Gastroenterology, Hepatology and Nutrition at the University of Louisville School of Medicine is recruiting a board certified hepatologist/gastroenterologist for our liver transplant program. There is considerable support for clinical/translation research and excellent collaboration. The University of Louisville is an equal opportunity affirmative action employer. Interested candidates are invited to submit a curriculum vitae. Contact Kristine Krueger, MD, Professor and Chief, Academic and Clinical Affairs, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40292. Email: email@example.com
Saint Luke's Hospital (SLH), a 600-bed tertiary hospital in Kansas City, is searching for BC/BE gastroenterologist. Interest in functional GI/motility disorders will complement the existing interests in the group. Join a 10-physician practice based at the beautiful Plaza district in midtown Kansas City. Saint Luke's Hospital is the primary teaching hospital for the University of Missouri-Kansas City (UMKC). Appointment will be at assistant/associate professor level and will involve education of fellows, residents and medical students.
Kansas City (population — 2 million) is known as the "City of Fountains" and features professional sports, jazz, world class BBQ, beautiful lakes and parks, and access to three of the top ranked public school districts in the U.S. Recently voted as having one of the "Kid Friendliest" suburbs by USA TODAY.
This employment opportunity with Saint Lukes Physician Specialists offers an excellent compensation and benefits package and is part of Saint Luke's Health System, a prominent 11-hospital not-for-profit health system based in Kansas City. All inquiries are confidential.
Please email your CV and letter of interest to:
Sreeni Jonnalagadda, MD, FASGE
Professor of Medicine, UMKC
Section Chief, Gastroenterology, SLH
Director of Interventional Endoscopy, SLH
Phone: 816-932-6916
Mick Allison
Director of Physician Recruitment and Retention
Saint Luke's Health System
Phone: 816-502-8865
New Jersey
Digestive Healthcare Center, a premier gastroenterology six-physician practice offering comprehensive services located in Hillsborough, NJ, seeks a board certified/board eligible gastroenterologist. EUS, ERCP and hepatology fellowship training is desired. Practice offers a competitive base salary, production incentives, a full and comprehensive benefits package, potential for ASC ownership, and partnership opportunity. Please contact Raymond Berrios at firstname.lastname@example.com.
New York
Newly formed Rochester General Regional Health System, following the merger of Rochester General Health System (www.rochestergeneral.org) and Unity Health System (www.rochestergeneral.org) in July 2014, is seeking a full-time BC/BE gastroenterologist to practice personalized, comprehensive medicine in a collaborative, cutting-edge environment. High-tech, minimally invasive techniques; opportunity for advanced clinical research; call schedule of 1:8; guaranteed salary for first two years; generous retirement benefits; full malpractice coverage; affordable, culturally rich community.
To apply visit: https://www.rochesterGeneral.org/careers/physicians or email your CV to email@example.com. Rochester General Health System is an Equal Opportunity / Affirmative Action Employer. Minority/Female/Disability/Veteran
Rhode Island
We are an 18-physician single-specialty private practice, with four main campuses across the state of Rhode Island and ownership in four endoscopy centers. We are seeking a BC/BE gastroenterologist for a partnership track position.
We are a well-established, forward thinking group, with deep ties throughout the community and a strong presence in four of the major hospitals in the area. There are voluntary opportunities to teach residents and fellows. ERCP is a plus. This is a chance to develop a strong long term outpatient practice.
Please send inquiries and CVs to email@example.com.
South Carolina
So is the difference YOU can make
Greenville Health System (GHS), the largest healthcare provider in South Carolina, seeks the following gastroenterologists to join our dynamic team.
Due to the development of a new GI division led by Dr. Gary A. Abrams, Greenville Health System (GHS), the largest healthcare provider in South Carolina, seeks to add qualified academic gastroenterologists/hepatologists as employed physicians. The position is primarily as a clinical educator/researcher. Research experience in IBD and motility preferred. We are also looking for an experienced individual to direct, develop and implement a GI fellowship program. ERCP/EUS training is not required.
Due to department growth, we are looking to add a qualified general gastroenterologist as an employed physician in an established outpatient multispecialty practice in the Greenville, SC area.
GHS employs over 12,000 people, including 800+ physicians on staff. Our system includes clinically excellent facilities with 1,662 beds on seven campuses. Additionally, we offer 15 residency and fellowship programs and a four-year medical education program: University of South Carolina School of Medicine–Greenville, located on GHS' Greenville Memorial Medical Campus. We are a designated Level I Emergency Trauma Center and also have a separate research facility.
Greenville, South Carolina is a beautiful place to live and work and the GHS catchment area is 1.3 million people. Greenville is located on the I-85 corridor between Atlanta and Charlotte, and is one of the fastest growing areas in the country. Ideally situated near beautiful mountains, beaches and lakes, we also enjoy a diverse and thriving economy, excellent quality of life and wonderful cultural and educational opportunities. We offer great compensation and benefit plans, paid malpractice insurance and full relocation packages.
Qualified candidates should submit a letter of interest and CV to: Kendra Hall, Sr. In-House Physician Recruiter, firstname.lastname@example.com, ph: 864-797-6114. GHS is an equal opportunity employer which proudly values diversity. Candidates of all backgrounds are encouraged to apply.


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Gardening Journals
We are on the edge of the Arctic outflow and our temperatures haven't yet been as low as forecast, hovering around 0C and sunny during the day, down to about -7C at night. Today I cleared the porch and cleaned garden tools. Spade, fork, hoe, rake and my bag of smaller tools got wiped with an oily...Clear -6°C / 21°F
Earliest I've seen this. Fortunately although cold, it's been still and clear– actually really nice fall gardening weather. I got the fake greens and lights out around the pond, although 2 of the strings were out so I have to get replacements. Looks pretty (I'll take a picture in the dusk when...Overcast 1°C / 34°F
November Bloom Day - Deep frozen primrosesOutside every plant is frozen, once we have snow they will probably unfreeze somewhat. The soil is so solid because it was completely saturated with water. The Contorted Hazel dropped its leaves overnight, only the tight, pale green catkins and tiny leaf buds hang from its branches. So now the...Clear -2°C / 28°F
It is a great day to garden so I have been potting up some plants and starting cuttings. I have taken cuttings of my Devil's Backbone plant that is growing in the front garden. We have a project going on in the front garden which is to lay black plastic on the house perimeter and on top lay p...Overcast 16°C / 61°F
I collected some of the remaining mimosa seeds from by the bus stop, and I'm going to plant them this weekend. Have elderberry and vitex soaking; they're from an herb shop, meant for herbal medicine, so they might not be viable, but I'm gonna plant them anyway, and see what happens. We're movi...
Mind you, I have consciously decided that I will no longer cooperate with the current news meme of making everything sound like it's the terrifying End of The World As We Know It. Ebola! Isis! Low Gas Prices! (yes there was a report that low gas prices are cause for panic). And of course ZOMG ...Overcast 1°C / 34°F
https://imgur.com/a/6jBp4Rain 7°C / 45°F
Realized that while burning the biochar kiln, which is located on the same side of the house as the intake for the air makeup, it will be necessary to turn off the air makeup to prevent it from smoking up the house.Overcast -8°C / 18°F
Size Reduction (Micronize) Reducing char particle size also dramatically improves response. This increases external surface area that is accessible to water, ions and microbes, and increases the rate is saturated. Char larger than dime-size must be broken down further for efficient action is...Overcast -8°C / 18°F


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Originally published Thursday, August 7, 2014 at 3:07 PM
'Burkholder': a touching second film from 'Old Goats' director
A movie review of "Burkholder," Seattle-area director Taylor Guterson's second feature starring the late Bob Burkholder as a senior slipping into dementia and Britton Crossley as the landlord who reluctantly becomes his advocate. It received 3.5 stars out of 4.
Special to The Seattle Times
Movie Review ★★★½
'Burkholder,' with Bob Burkholder, Britton Crosley, Dave VanderWal. Written and directed by Taylor Guterson. 81 minutes. Not rated; for mature audiences. SIFF Cinema at the Uptown. Guterson will appear at the 4:30 and 7 p.m. shows Friday and 2, 4:30 and 7 p.m. Saturday. For an interview with the director, go to seattletimes.com/movies.
Fans of Seattle-area writer-director Taylor Guterson's first feature, "Old Goats," might approach his second film, "Burkholder," with a sense of déjà vu.
Indeed, as some filmmakers do, Guterson chose to work again with the same principal cast from his earlier movie: in this case, three nonprofessional actors, all local seniors, from "Old Goats."
But there the significant similarities between the two films end.
"Old Goats" was the darkly comic story of three Bainbridge Island men transitioning less than gracefully into their later years. Finding his inexperienced actors — Bob Burkholder, Britton Crosley and Dave VanderWal — to be wonderfully creative with improvised dialogue, Guterson's feature debut had wit, spontaneity and spark.
Those qualities are all present in "Burkholder," too, but this time the story is a tougher sell. The late Burkholder plays the almost-90-year-old Teddy, slipping into dementia and growing increasingly frail. With no family to care for him, Teddy's landlord and friend, Barry (Crosley), reluctantly becomes his advocate even as he tries to move Teddy out. VanderWal has a supporting role as owner of a failing outdoor-adventure company.
While "Burkholder" (Guterson named the film after his actor, who struggled to finish shooting) has its moments of heartbreak and sadness, it is also rich in humor and surprises. The director sometimes engages a free-floating point of view via his camera angles and editing, and there are scenes — such as Teddy talking to himself in a mirror — that are wildly unexpected.
In the end, "Burkholder" is about what we owe each other in loyalty, sacrifice and kindness. This very human film deserves a wide audience.
Tom Keogh: email@example.com
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The CSI/Two and a Half Men writer switcheroo -- loved it!
But first there was Two and a Half Men. In an episode called "Fish in a Drawer" (and if somebody could explain what that title means, I'd be most appreciative), the story picked up after Evelyn married Teddy. In the teleplay by CSI regular writers Evan Dunsky and Sarah Goldfinger, Charlie and Courtney check out of the reception for a little romp in his room upstairs only to find Teddy's dead bod on the bed. Talk about spoiling the mood. Teddy wasn't only a corpse, he was a corpse with his pants pulled down around his ankles and lipstick stains on his hoo-ha. The cops were called in, a detective who was a dead ringer for Marg Helgenberger -- played by redhead Jamie Rose -- had the vaguely Bondian name of Jagov, Sloane Jagov. Naturally, Charlie had to make a move on her. He couldn't keep his eyes off her cleavage.
Dourdan leaving CSI
Dourdan, who plays CSI Level 3 Warrick Brown, and CBS/Paramount came to a mutual decision not renew the actor's contract with the show.
William Petersen agrees to stay with CSI
However, it is true that William Petersen is returning to CBS's CSI for the ninth season. This is great news for fans of the show -- and the star -- because for years now he's been yelping about leaving the hit series to do other things. Last year, for example, he was written off the show for a brief hiatus in which Liev Schreiber was cast as a temporary replacement for Gil Grissom in the Las Vegas crime lab.
CSI: Magic Mountain - it's true
CSI, Two and a Half Men to trade writers?
It may sound a little bit like a headline from The Onion, but it's actually in the works, according to CSI producer Carol Mendelsohn.
Speaking at a Banff event in Canada earlier this week, Mendelsohn said she got a call from Two and a Half Men creator Chuck Lorre, who suggested the switch. I'm not sure if it would be permanent, but it's something they could do for an episode or two. CSI will also go on location to San Francisco this season, and next season might go to London.
Maybe the Two and a Half Men writers can have Grissom sleep with a different woman every night, and maybe even hire a wisecracking kid to help with a murder investigation. He can be a prodigy who doesn't do well in school but is a genius at forensics.
A sad day for television?
For the past week, CBS has been running a sad preview for tonight's episode of CSI, the last one for star William Petersen (for a while anwyay). Liev Schreiber joins the cast soon.
Hey, I'll admit I don't watch this show (even though it's the MOST IMPORTANT SHOW IN THE UNIVERSE). So I ask fans: is this departure as big as they're making it out to be. Yes, yes, I know he's the star of the show and he's the leader of the team and all that. But the commercials make it sound, with the "you never thought he'd leave" voiceover and the tinkling piano and the emotion, you'd think that Lucy Ricardo was just hit by a bus or maybe Petersen had died in real life and this was his last show.
Why is Petersen leaving temporarily anyway? To star in a play? Burnt out? Contract negotiations? The episode preview should get into that: "People come and go...but you never thought he'd leave...but due to other commitments and just a feeling that he had to get away for a while, our star has to leave and will be replaced by another actor...tonight, on a very special CSI."
Liev Schreiber takes over on CSI
Don't panic, William Petersen fans, don't panic! It's only temporary.
Petersen is taking a break from the show for a handful of episodes starting January 12, and Schreiber will play another investigator who comes in to solve bizarre murders in Las Vegas.
I wonder if this is a tryout for Schreiber. It's often been rumored that Petersen would not stay with CSI forever, so maybe producers are taking this break as an opportunity to try out someone else in the role if Petersen decides to move on. I'm kinda surprised that Schreiber took the gig, since he's been focusing on movies and the stage for several years, but he could add something interesting to the show. Though I don't watch the show anymore. Is there anything interesting happening on any of the CSIs these days?
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Veterans' Day Holiday
For Veterans' Day, Tuesday, November 11th -
Clovis City offices will be closed WITH THE FOLLOWING EXCEPTIONS:
- Normal Police and Fire Services
- Normal refuse and recycling pick up. Please have your containers at the curb no later than 6a.m.
- Limited Stageline routes with reduced operating hours. NO SCHOOL ROUTES.
- Roundup Service WILL operate, but limited.


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Carmelo Anthony or LeBron James made up Plan A. Pau Gasol was Plan B.
Derrick Rose, Joakim Noah, Pau Gasol, Jimmy Butler. These are the Chicago Bulls names you hear over and over again. Maybe the water cooler buzzes on an off day about rookies Nikola Mirotic and Doug McDermott. You might even discuss super-sub...Show More Summary
Derrick Rose and Pau Gasol returned as the Bulls hung on in Utah. [ more › ]
SALT LAKE CITY, Utah - The Bulls limped into town with continued uncertainty about the availability of injured veterans Derrick Rose, Pau Gasol and Kirk Hinrich for Monday night's game against the Jazz. "We will see how they are after the shoot-around," Coach Tom Thibodeau said Monday morning at Energy Solutions Arena. Show More Summary
TUALATIN, Ore. -- Speaking before Sunday's practice at the Portland Trail Blazers' practice facility, Bulls coach Tom Thibodeau said Taj Gibson got sent home to Chicago to be examined by team doctors.
The Chicago Bulls played without Derrick Rose and Pau Gasol last night, and got rolled by Boogie Cousins and the Kings as a result. They kept it close through the first half, but the game started to slip away from them in the third quarter,...Show More Summary
No one will make too much of the Sacramento Kings' 103-88 victory over a Chicago Bulls team missing stars Derrick Rose and Pau Gasol. But there's a lot to like about the team's promising 7-5 record, and there's even more to like about the emergent "Big Three" carrying the load. Show More Summary
The surprisingly potent Sacramento Kings host the Chicago Bulls Thursday. The Bulls have won each of their first six road games this season, but they will go against Sacramento without the services of Derrick Rose and Pau Gasol, as noted on the TNT telecast. The game tips off at 10:30 p.m. Show More Summary
SACRAMENTO, Calif. — The Bulls' season-high, seven-game trip continued with Thursday night's late tipoff against the Kings, and Pau Gasol's absence to a strained left calf offered Nikola Mirotic another opportunity.
The Chicago Bulls have unexpectedly held their own early on in the NBA season despite the injuries to Derrick Rose. Pau Gasol has been playing better than expected, but the biggest surprise might be Jimmy Butler's rise as a legitimate...Show More Summary
The Kings put their hot start to the test against Chicago without Derrick Rose and Pau Gasol. Elsewhere, the Clippers play their third game in four nights, this time against Chris Bosh and the Heat. Doc Rivers' second season leading the Los Angeles Clippers came with championship expectations, but so far it's only resulted in frustration. Show More Summary
The Clippers face the Heat hoping to fix their defensive issues, and the Bulls will visit California's capital with Pau Gasol and Derrick Rose sidelined. Doc Rivers' second season leading the Los Angeles Clippers came with championship expectations, but so far it's only resulted in frustration. Show More Summary
SACRAMENTO, Calif. --- The Bulls haven't won the first two games of their annual extended November trip since 1996.
LOS ANGELES -- Speaking to reporters before Wednesday's practice at the Clippers' practice facility, Chicago Bulls coach Tom Thibodeau said Derrick Rose would participate and Pau Gasol would not.
Despite not having Derrick Rose and Pau Gasol in the lineup, the never-say-die Chicago Bulls overcame a 14-point deficit Monday night, and beat the LA Clippers 105-89. Doc Rivers said […] The post Chris Paul Says Clippers Home Loss to Bulls Felt 'Like a Road Game' appeared first on SLAMonline.
There have been a handful of fast starts from teams and players this season. Pau Gasol is arguably the best offseason acquisition, Dwyane Wade has shown flashes of his pre -LeBron form, and Kobe Bryant has turned back the clock and is putting up big numbers. Show More Summary
LOS ANGELES — Despite participating in the morning shootaround at UCLA, Bulls big man Pau Gasol was scratched late Monday with a strained left calf.
Ahead of Thursday night's Chicago Bulls-Toronto Raptors tilt, Joakim Noah spotted teammate Pau Gasol studying the Raptors' 120-88 beatdown of the visiting Philadelphia Sixers last Sunday. Noah candidly shared his […] The post Joakim Noah on Scouting the Raptors vs Sixers: 'I Wouldn't Watch That Sht' appeared first on SLAMonline.
The Bulls improved to 6-2 with a 102-91 victory Monday over the Pistons in which the lineup of Derrick Rose, Jimmy Butler, Mike Dunleavy, Joakim Noah and Pau Gasol played together for the first time.
D-Rose back. Every other game.


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In Java, one can declare a variable parameterised by an "unknown" generic type, which looks like this:
Foo<?> x;
Is there an equivalent construct to this question-mark, in C#?
From C# from a Java developer's perspective by Dare Obasanjo:
In certain cases, one may need create a method that can operate on data structures containing any type as opposed to those that contain a specific type (e.g. a method to print all the objects in a data structure) while still taking advantage of the benefits of strong typing in generics. The mechanism for specifying this in C# is via a feature called generic type inferencing while in Java this is done using wildcard types. The following code samples show how both approaches lead to the same result.
C# Code
Java Code
AFAIK you can not do that in C#. What the BCL does and there are plenties of examples there is to create a class that is not generic and then create a generic class that inherits the base behavior from the previous one. See example below.
The you can write something like this:
While admittedly being not the clean approach, using
It isn't (quite) true that there is no equivalent in C#. There is no static equivalent that you can use as a type, or call methods on, true enough. For that, use Jorge's answer.
On the other hand, sometimes you need the equivalent idea for reflection, and there is an equivalent there. If you have:
you can get a
This is useful when you want to use
There isn't an equivalent syntax in C#.
No, there isn't really the same concept in C#. You would need to refer to a base class of Foo (maybe a non-generic Foo), or make the method you're working in generic itself (so that you can refer to Foo, and let the caller of your method determine what T is).
Hope that helps.


text:
Tap 42 Announces Second Location in Boca
By Nicole Danna
Credit Card Breach at P.F. Chang's in Palm Beach
By David Minsky
Myapapaya's Dreamy Greeny is the Best
By Sara Ventiera
Photos: Bull Market in Ft. Lauderdale
By Candace West
Coconut Water May Not Be All It's Cracked Up to Be
By Sara Ventiera
National Tequila Day is July 24, Six Drinks to Try
By Nicole Danna
Top Three Sriracha-Flavored Foods
By Sara Ventiera
El Bohio Offers Cuban, American Cuisine in Lantana
By Nicole Danna
It no doubt sounds like gastronomic blasphemy to declare that a chain restaurant turns out superior ribs. But the barbecued ribs at J. Alexander's really are something special: big slabs of Danish baby-back ribs covered with a dark sauce that's not too tangy and not too sweet. The ribs are pork -- beef can't compete -- and they're slow-cooked to moist, falling-off-the-bone perfection. And unlike the highly variable ribs at so many barbecue joints, they're consistently good, which to our mind is an undervalued virtue when it comes to ribs. Skeptical? We took a gang of folks from the Deep South's Barbecue Belt to J. Alex's for the ribs, and they left with their bellies full and smiles on their faces.


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Innovation promises expanded roles for microsensors
February 7, 2012
Researchers have learned how to improve the performance of sensors that use tiny vibrating microcantilevers to detect chemical and biological agents for applications from national security to food processing.
The microcantilevers - slivers of silicon shaped like small diving boards - vibrate at their natural, or "resonant," frequency. Analyzing the frequency change when a particle lands on the microcantilever reveals the particle's presence and potentially its mass and composition.
The sensors are now used to research fundamental scientific questions. However, recent advances may allow for reliable sensing with portable devices, opening up a range of potential applications, said Jeffrey Rhoads, an assistant professor of mechanical engineering at Purdue University.
Creating smaller sensors has been complicated by the fact that measuring the change in frequency does not work as well when the sensors are reduced in size. The researchers showed how to sidestep this obstacle by measuring amplitude, or how far the diving board moves, instead of frequency.
"When you try to shrink these systems, the old way of measuring does not work as well," Rhoads said. "We've made the signal processing part easier, enabling small-scale, lower-power sensors, which are more reliable and have the potential for higher sensitivities."
Findings are detailed in a paper appearing online this week in the Journal of Microelectromechanical Systems, which is available at http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6145730. The paper was written by graduate research assistants Vijay Kumar and J. William Boley, undergraduate student Yushi Yang, mechanical engineering professor George Chiu and Rhoads. An earlier paper was published in April in the weekly journal Applied Physics Letters.
The work is based at the Dynamic Analysis of Micro- and Nanosystems Laboratory at Purdue's Birck Nanotechnology Center.
The aim is to apply the new approach to build sensors capable of reliably measuring particles that have a mass of less than one picogram - or trillionth of a gram - at room temperature and atmospheric pressure.
The microcantilever sensors have promise in detecting and measuring constituents such as certain proteins or DNA for biological testing in liquids, gases and the air. The devices might find applications in breath analyzers, industrial and food processing, national security and defense, and food and water quality monitoring.
"One question about these sensors is whether they will continue to work in the field," Rhoads said. "We've been doing a lot of blind, false-positive and false-negative tests to see how they perform in a realistic environment. We've had only a few false positives and negatives in months of testing."
The findings focus on detecting gases and show that the new sensors should be capable of more reliably measuring smaller quantities of gas than is possible with current sensors.
Measuring amplitude is far easier than measuring frequency because the amplitude changes dramatically when a particle lands on the microcantilever, whereas the change in frequency is minute.
"We haven't beaten the sensitivity of all other sensors yet," Rhoads said. "But the difference is that we are trying to do it with a compact device that is truly implementable at the microscale, while many others use fairly large laboratory equipment."
The researchers tested the cantilevers in a chamber filled with precisely controlled quantities of methanol to study their reliability. A patent is pending on the invention.
The research has been partially funded by the National Science Foundation. Student support was provided by Purdue and the Purdue Research Foundation.
Writer: Emil Venere, 765-494-4709, firstname.lastname@example.com
Sources: Jeffrey Rhoads, 765-494-5630, email@example.com
George Chiu, 765 494-2688, email@example.com
Contact Details
- Jeffrey Rhoads
- email@example.com
- 765-494-5630
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Seminars set for Discovery Learning Research Center director candidates
November 26, 2014
The candidates for the position of the director of the Discovery Learning Research Center (DLRC) will give seminars on their vision for the future of the DLRC.Read Full Story
Purdue Research Park-based renewable chemicals startup receives $50,000 grant from Elevate Ventures
November 25, 2014
Spero Energy Inc., whose technology could make biofuel production more efficient and creates high-value, renewable chemicals used in the flavor and fragrance industry, has been awarded a $50,000 grant.Read Full Story
NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation magnetic storage
November 24, 2014
Researchers at Nano-Meta Technologies Inc. (NMTI) in the Purdue Research Park have shown how to overcome key limitations of a material that could enable the magnetic storage industry to achieve data-recording densities far beyond today's computers.Read Full Story


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Houses to let in Mitchell Street, Eccles, Manchester M30 - 1 bedroom
£180 pcm (£42 pw) Just added
Salford, Manchester M50Detached house to rent - 1 bedrooms
3 Rooms Available in Salford £180pcm More details
Note: Distances are straight line measurements
- Manchester United Football Ground (1.0 mile)
- Salford Crescent (1.1 miles)
Marketed by Ad Hoc Property Management, L3. Call 0151 382 8514£395 pcm (£91 pw)
Bridgewater Road, Worsley, Manchester M28Property to rent - 1 bedrooms
1 bed apartment in the centre of Walkden, recently refurbished with modern decor kitchen and shower room. Great access for schools and transport links Internal viewing a must to appreciate the accomodation on offer.... More details
Note: Distances are straight line measurements
- Walkden (0.3 miles)
- Kearsley (Manchester) (1.8 miles)
Marketed by Reeds Rains, M28. Call 0161 884 0397


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Founder of Market Me Media ,, mrket.me ,, Freelance Developer from /AmericA\ Minimal Techno Enthusiast! Hipsta WannaB.! http://Mrket.me
Hello Monday creates unique digital experiences and identities that tickle the brain and please the eyes.
ultranoir is a french digital design studio, based upon the know-how and technology for creative design, producing innovative and effective websites.
Built on creativity, innovation & a DIY ethic.
Innovation through Storytelling and Technology.
Google… is Google.


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Jeezy - Jizzle
Artist: Jeezy
Featuring: Lil Jon
Producer: Shawty Redd
Album: Thug Motivation 103
Avg Rating: 2.6 ( 36 votes )
When Jeezy and Lil' Jon step into the recording booth together, listeners expect something big, bombastic and totally over-the-top. Well, I'm pleased to announce that Jizzle, the newly-released lead single off the former's forthcoming senior set, fits the bill and then some. Over a Shawty Redd-produced instrumental that sounds something like Wagner's Ride of the Valkyries performed in the middle of a power-tool convention, the legendary trapper launches into an epic bout of sh*t-talking, peppering his verses with some of the most outrageous boasts I've heard in a minute (it's not every day you hear a rapper brag about hatin' so much he "should be a f**king Nazi."). For his part, the Crunk King doesn't disappoint, shouting his way through bars that would leave a lesser man's vocal cords in tatters. So, Jeezy devotees, is Jizzle everything you hoped for in a lead single? Whatever your opinion, you'll be able to hear plenty more from the Florida heavyweight on September 28, when Thug Motivation 103 hits store shelves and online retailers.
Written by richard on 07/20/10
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"Grew Up a Screw Up" (2006)
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text: Cons Extremely small room alloted on online booking Bathroom and bedroom were cramped . Noisy as the room was close to reception. Process of online reservation was extremely unprofessional. Pros Near to Main market Police Bazar Wi Fi was working Never do an online booking in this hotel. They give the worst room available to hapless travelers and that too... More


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Scotch is the official beverage of the 1 percent. But now tradition-busting bartenders are treating it like a blue-collar booze, mixing blends and smoky single malts into cocktails. Here's how to take scotch back from the neat freaks read more
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Motorcycle Metal Pallet/Skid for sale
1 Attachment(s)
Hello fellow world riders!
Back home and just off-loaded a shipment from Germany, yesterday, and now I have a heavy-duty steel motorcycle-specific skid that I don't need. If you take your bike by trailer to any rallies or are thinking of shipping it somewhere, then this is better than any wood pallet you'd find. This can be used for Air transport (check with the airline if they also want a plywood box around it), container, or simply trailer/flatbed transport. It has wheel wells to hold both wheels, flip up bars at all 4 corners to create a box frame for protection, and tie-down hooks. This is very heavy duty steel, fully welded, and super strong. It's from Stefan Knopf's if you are familiar with them. If you are in the Toronto area, I can meet you or you can come and pick it up. It is just like this on in the picture (bike not included of course :scooter:) From what I can find on the web, to buy a new one costs $900 but that would be ridiculous to ask even half that from a fellow HUBBer. I think $100 would be fair, just to recover some costs and pass something on that could be useful to another rider.
PM me or call my cell 416-999-5546
|All times are GMT +1. The time now is 09:22.


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Live in Ma but came into Boston when we lost power from the blizzard. Chose the Westin based on location and reviews. Service was very good- valet was quick, luggage got to room quickly and ask for late checkout was done no questions asked. Room was a good size and clean. Rain shower and nice bedding and mattress were food extras. The fitness facility was clean had a fair amount of cardio equipment and things like balls, etc. convenient location as you can get to Copley, the prudential center and around the general area without going outside. Had dessert and drinks in Bar 10, which was very good and had brunch here as well which was good. The only two negatives were wifi, parking and having to pay for Disney TV shows were all a bit excessive.
- Official Description (provided by the hotel):
- Our Boston Hotel features a great location and comforting accommodations. The Westin Copley Place is linked to the Hynes Convention Center and is only a stroll away from Boston's best shopping. ... more less
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ISRAEL21c compiles a list of the 10 most extraordinary medical devices and pharmaceuticals that promise to revolutionize global healthcare.
Helping preemies breathe easier
The novel Pneumonitor device alerts nurses well before ventilated preterm newborns go into respiratory distress.
'Lazy eye' glasses help kids overcome amblyopia
Amblyz, invented by Israeli physician Omry Ben-Ezra, wins international prize for innovation and 7,000 orders from Turkey.
New device for sleep apnea is easier on the heart
Israeli company's SomnuSeal mask is more comfortable for patients who can't tolerate the existing option, and it protects cardiac health too.
New Orcam device turns the world into speech for the blind
OrCam is based on artificial intelligence and special algorithms built into a tiny computer that clips onto your eyeglasses.
Brainiacs see the future at BrainTech, Tel Aviv
'This conference — this magnitude and scale — I have never seen anything like it in the world,' says participant from Brown University.
The top 12 most amazing Israeli medical advances
Israel is a powerhouse in medical innovation. We give you a dozen standouts from a field with many exciting, game-changing candidates.
Top 10 incredible Israeli advances in vision
Israel's scientists are behind a range of innovations that dramatically improve eyesight or quality of life for people with vision impairments.
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Itamar's fingertip test
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We love beer. That's why we're devoting an entire year to discovering (and drinking) cold ones from near and far. Know of a beer worth shouting out? Send us a note at email@example.com.
These elder statesmen of brewing from Michigan have been delivering an eclectic assortment of brews for longer than almost anyone, and they're always worth drinking. Bell's Cherry Stout is no exception. We already know Bell's can make a great stout, so it's no surprise that the base beer has all the dark roast, bitter mocha and rich chocolate notes we'd expect. Throw in tart Michigan-grown cherries, though, and it's a whole new ballgame: The fruit adds a tartness that cuts through the expected burnt sweetness without overpowering it. Blasting you with cherry in the middle of the sip, the beer still manages to finish with a touch of coffee and cocoa. A perfect dessert beer and a great complement to ice cream, try this brew at Jon's Bar & Grille or Churchville Inn.
PW's Year of Beer: Cigar City Good Gourd
PW's Year of Beer: Ommegang Game Of Thrones Valar Morghulis
PW's Year of Beer: Sly Fox Chester County Bitter
PW's Year of Beer: Morland Old Speckled Hen
PW's Year of Beer: Lagunitas Imperial Red
PW's Year of Beer: Victory Moving Parts IPA
PW's Year of Beer: Penn Brewery Brick Biergarten IPA


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Blogs Liberty and Power Santorum and Big Government ConservatismJul 3, 2008 1:52 pm
For several years now, I have been going on and on about the continuing growth of the religious right in conservative circles. My antipathy to theocratic conservatism had been at fever pitch long before I wrote my essay,"Caught Up in the Rapture," which, with its sister essay,"Bush Wins!," predicted a Bush victory a good six months prior to the 2004 election.
In this context, a recent Jonathan Rauch essay,"America's Anti-Reagan isn't Hilary Clinton. It's Rick Santorum," has been making the rounds all over the blogosphere; it's a dissection of Pennsylvania Senator Rick Santorum's anti-libertarian philosophy.
What one will not find in Rauch's essay, however, are two words:"Bush" and"Iraq." In my view, Santorum's new book, It Takes a Family: Conservatism and the Common Good, is only the newest manifestation of a religious conservative movement, whose titular head is George W. Bush. Whereas the religious conservatives wish to remake the culture and politics of this country, the neoconservatives wish to remake the culture and politics of the Middle East. Together, these tendencies make for one very potent anti-libertarian, anti-individualist politics.
What hope does a religiously based conservative administration have to inspire secular, liberal democracies in the Middle East when it is at war with both secularism and liberalism at home?
I discuss these themes in greater depth at Notablog.
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Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
1/3 Photos of Greek Lamb Casserole
Prep Time:
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This was printed in our local paper several months ago. It is also one of those I clipped to make and then misplaced. It sounds so wonderful. I know if I post it, I want loose it.
Units: US | Metric
Serving Size: 1 (395 g)
Servings Per Recipe: 6
Every recipe, menu, tip and how-to is right here, at your service.


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The Pratt Area Community Council is still accepting applications for 40 Vanderbilt, the affordable studio apartment building within the under-construction Navy Green complex. PACC held the first lottery here last year. According to a bulletin by Community Board Two, studio units are available for single adults with incomes ranging from $21,774 to $28,650, and monthly rents are between $492 and $664. The units come furnished and with on-site social services provided by the nonprofit Brooklyn Community Housing and Services. Apartments are available for immediate occupancy. Here are all the details about the building and how to apply. When all is said and done at the Navy Green project, there will be 458 units total (both affordable and market rate) as well as commercial space, a common green area, and community facility spaces. Update: this post has been updated due to previous inaccuracies about the rents and income ranges.
More Affordable Units Available at Navy Green [Brownstoner]
Photo via 40Vanderbilt.org
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Who designed that?, it looks like a bad LSD trip.
Looks like they took cues from some of the finest government housing complexes in Nuuk and applied them lovingly here –
Looks pretty groovy to me.
i lived thru the "goovy era", so I am over it, but i get ya !!
It was developed by the same company doing the supportinve housing near me on Putnam. I had hoped for a similar European modern design look, but alas we got a more mundane (but not horrible) pseudo-Victorian with mansard roof.
That would be so nice to see on a cold, grey and dreary day!
how many units set aside for the "chronically homeless"? – as covered by the last post about this building on B'stoner.
how many units set aside for the "chronically homeless"? – as covered by the last post about this building on B'stoner.
Interesting design.
Interesting design.
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November 26, 2014
Stay up-to-date with KAKE News:
So when is the best time to do things? Whether you're shopping, or trying to get a raise, timing is everything. This information comes to us courtesy of this month's Reader's Digest.
The best time to buy a car is the end of the month. Sales people have monthly quotas to meet. They usually want to deal near the end of the month.
The best time to buy a house is September. Spring and summer are the time to sell. By September, sellers may be willing to deal and most kids need to be relocated to a new school by then.
You should make doctor appointments between 8 and 9am. Doctors overbook appointments, so the later in the day, the more backed up they are.
The best time to go grocery shopping is between 9:30am and 2pm Tuesday and Wednesday. That's when the crowds are small and the shelves are newly stocked. That equals more stuff, fewer shoppers.
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Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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We are closed for camping for the winter season. It's time to plan for next year!
Book your site for next year NOW! To get you seasonal spot at the same price as this year phone the sales office or make an appointment to view and select your site.
(780) 922-3045
Fully Furnished RV Rentals
We have fully equipped RV's ready to rent (subject to availability) for your convenience… more
Due to concerns about disease and/or insects coming into the resort we insist that NO outside wood can be brought in. Outside wood will be confiscated and not returned. Wood 'found' on the resort may NOT be used for campfires.
Emmitt's Dry Goods & Confectionary
The store provides a wide variety of food, necessities, snacks, picnic supplies and … more
Park Rules
Comfort and enjoyment for all depends on cooperation and consideration. We ask that you be familiar with the Park Rules more…