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The British Academy of Film and Television Arts Los Angeles announced that the recipient of the 2012 Stanley Kubrick Britannia Award for Excellence in Film will be Daniel Day-Lewis. Day-Lewis, a two-time Academy Award-winning actor, will be honored at the BAFTA Los Angeles Britannia Awards on Novemb...Read More »
The BAFTA LA 2012 Britannia Awards (November 11) will honor "Lincoln" star Daniel Day-Lewis with the Stanley Kubrick Britannia Award for excellence in film. The pre-selected awards, which this year also honor Daniel Craig, Quentin Tarantino, Trey Parker, Matt Stone and Will Wright, provide a BAFTA O...Read More »
"Frankenweenie" is not only Tim Burton's best film since "Big Fish" (another rite of passage story), but also a lock for a best animated feature nomination. In fact, the Oscar arguably appears to be Burton's to lose, though it's shaping up to be quite a race with two other tantalizing retro movies y...Read More »
An intense and patriotic new trailer for Steven Spielberg's "Lincoln" (November 9) premiered during the presidential debate. Political news wonks may seem an odd target audience for a Hollywood movie, but it makes sense for a period drama that is essentially about governing. "Lincoln" spends most of...Read More »
Several indie movies are looking to make a late-year comeback on the road to the Oscars, most notably three summer hits. Fox Searchlight is pushing Brit import "Best Exotic Marigold Hotel" ($46 million domestic) as well as Sundance sweetheart "Beasts of the Southern Wild" ($...Read More »
In advance of its New York Film Festival screening next week, Israel's Oscar entry "Fill the Void," has been acquired by Sony Pictures Classics. Israel sends its Ophir Best Picture winner to the Oscars.Read More »
There's been some significantly sesmic shifts in the Oscar field in the last few days, and not just the surprise announcement that "Family Guy" creator Seth MacFarlane will be hosting the ceremony itself (for the record, this writer dislikes pretty much everything he's ever done, but based on his 'S...Read More »
I don't get it. Yes, the Academy wants to make people think that it is hip and young and I understand that, but Seth MacFarlane? The guy who directed Ted (which was a huge hit) and the creative genius behind Family Guy to host the Oscars? I read yesterday that he is only the second host after El...Read More »
Werner Herzog dispensed sage advice Sunday during the International Cinematographers Guild's 16th annual Emerging Cinematographer Awards at the Directors Guild of America Theater in Los Angeles. Among his recommendations to the next generation of cinematographers were to seek out knowledge of ce...Read More »
Ang Lee's 3D epic opened the New York Film Festival Friday night and quickly sparked a storm of raving tweets heralding it as the one to beat come Oscar-time. Going into the premiere, buzz may have been mixed on the risky project but now it seems like it could pay off in a big way. Will it?Read More »


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Town Square
Understanding and rehabilitating the teen brain
Original post made on Jun 11, 2012
Read the full guest opinion here Web Link posted Friday, June 8, 2012, 12:00 AM
Comments (3)
a resident of Palo Alto High School
on Jun 11, 2012 at 4:33 pm
Very nice and well written op ed. Good thoughts to ponder. Shame it didn't make it on the online version!
a resident of Midtown
on Jun 11, 2012 at 4:44 pm
The Military has lots of experience in dealing with " the teen brain"
as lives depend upon the right approach which involves
Lots of exercise
Clear rules
Clear consequences
Personal and group challenges to build cohesion, personal honor, resilience and self discipline
Teens also needs lots of sleep and "a lights out" on school nights of 10 pm.
a resident of Midtown
on Jun 11, 2012 at 6:01 pm
Great essay! It is both informative scientifically, and persuasive in promoting healthy habits. Keep Was this student in 6th, 7th or 8th when they wrote this piece?
Whatever your age, keep up the good work!
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subset: commoncrawl


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He's a fun champion, learning how to aim his things can be tricky.
But oh my goodness he has amazing burst damage.
Senior Member
A good vegair.... is something to fear.
A great vegair is a god
I kinda regret buying him =/ too much focusing on last hitting with Q when his big damage spike comes from E which scales better but is hard to get off because it has a longer delay than his stun.
If you like killing people instantly, his burst easily does upwards 2500 dmg (300ish ap + deathfires) in 1.7 seconds.
Veigar is difficult since he realise on his W for the real kill, and its a pretty hard skillshot to land since its really easy to dodge
I don't regret buying him, I wish I played him as often as I used to, he's pretty fun if you're into bursting people down fast
He has a terribly boring early game, is difficult to play well, and not so useful given the current metagame and general lack of ap champs being played these days (with the exception of vlad and morg, whom both have ways to completely ruin Veigar's day). Oh, and he's also extremely vulnerable early game.
If you can get past those things, hes a blast to play. Nuking someone down from 100% to 0 in the space of a second never gets old.
I don't regret buying any of the champions because for some reason I feel the need to have all of them.
Playing too much Pokemon as a young'un ruins you for life.
Can't go wrong with veigar
He is a hard counter to ANY ap stacking character and his stun is imo the best in the game, the only stun that you can hit every enemy champ in one casting.. and with a little cdr its castable every 13 seconds or so. but he is squishy run from trynd.
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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26 Nov 2014
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Gather round, front and center, the King finna enter
from B.o.B (Ft. Playboy Tre & T.I.) – Bet I Lyrics on Genius
Ooh, T.I.'s going to tell us a story!
To help improve the quality of the lyrics, visit "Bet I" by B.o.B (Ft. Playboy Tre & T.I.) Lyrics and leave a suggestion at the bottom of the page


text:
What I Am Thankful for this Holiday Season
As winter approaches, the trees are bare except for a few remaining leaves dangling from their branches. Blowing in the wind are only shadows of the rich green shapes that have dried and fallen to the ground.
A tree losing its leaves is a good metaphor for the effects of addiction. Drugs and alcohol strip away just about everything leaving only shadows of the original self. At first, the high is so pleasurable that all seems well, but gradually the seasons change.
I don't recall the moment when I crossed the line into addiction. I only know that alcohol eventually became the central focus of my life. Sitting in jail, I was dazed by the night's events. Would things get better? Could I change? What was going to happen? Should I end it all? These were the questions spinning around in my head after my arrest for driving under the influence (DUI). Earlier that night, I entered a freeway traveling southbound in a northbound lane. Realizing the signs were facing the opposite direction, I tried to turn around but ended up in a ditch.
Years before, I was so proud when I graduated from boot camp. Marching across the parade deck filled me with hope, ambition, and a desire to succeed. There I sat wondering what would become of me now, but fortunately God had a plan. My incident required a mandatory dependency screening, which came back no-diagnosis. Fearing the repercussions on my career, I lied out of self-preservation on just about every question but my name. My job was one of the few remaining leaves hanging on a limb.
Without a diagnosis, the military had limited options to get me help. My supervisor—a man I have come to regard as a personal hero—introduced me to recovery-based support groups. Sitting across from me after my DUI, he must have seen something worth saving.
Compassion is an emotion one never fully appreciates until one receives it from another. My supervisor could have thrown the book at me. Instead, he chose a different path and adopted a wait-and-see approach. As long as I took recovery seriously, he refrained from imposing punishment. Thirty days turned into a year, then two, then three.
The evolution of recovery is much like a tree budding in the spring. The depths of mental darkness to which drugs and alcohol can take a person are indescribable. Addiction ravaged my soul. In recovery, I learned that one has to heal internally before he can really begin to grow. Recovery helped me clean house from the inside out, and I began to take responsibility for my life.
My experience placed me in a position to pass along to others the opportunities that were provided to me. People tend to view a person who has reached bottom through the lens of what brought the abuse to everyone's attention. I see them through the eyes of one who knows what recovery can make possible.
Eleven years ago, I was a Second Class Petty Officer sitting in jail without hope, without a plan, without a future. Following recovery, I have gone on to have a successful career. I served as an Information Technology Regional Systems Manager. I deployed to the Middle East as Chief of a Combat Information Center and completed an operational tour for a Tactical Maritime Safety and Security Team as a Planning Officer. Currently, I support the mission of the Office of National Drug Control Policy.
Midway through a master's program in mental health counseling, I now have a better understanding of the physiological, psychological, and sociological issues surrounding addiction. I often think of the support I received, and the course my life may have taken without it. Most notably, I think about what might not have been – how I never would have met my wife or have been blessed with our two little girls.
I am thankful for the second chance I did not deserve. I am thankful for my supervisor, who reached out and guided me toward help, and for the recovery programs created by others before me. I am thankful for God's grace, my family, and our country. Recovery is not only possible; it is likely when good people are there to help. A tree that sheds its leaves still has a world of potential within.
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text:
HOT TOPICS: Alcoholism Addiction AA Cocaine Heroin
Cops Nab Naked Priest on Drunk Driving Spree
The Catholic Archdiocese of Detroit takes a dim view as its man is pulled over a block away from his church. MORE
Morning Roundup: March 20, 2012
Women who work out drink more, 12 Mexican cops killed for investigating beheadings, and Channing Tatum saved 21 Jump Street co-star Jonah Hill from jail. MORE
The Quick Fix: A Real-Time Round-Up of Today's News
By Will Godfrey
House Reps Want Medical Marijuana Crackdown Stopped, Prescription Pills are East Tennessee's New Crack, and Yoda Caught Drunk Driving by German Cops. MORE
Video: Topless Drunk Woman Hits 128mph in Thrilling Cop Chase
Being drunk, naked and violent when you're arrested is a surefire way to make a video go viral. MORE


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Shutterstock Illustration NPP.1 RELATED: Shh … Got Three Indonesian Nuclear Reactor Powerful robots are Against Radiation Reality and Expectations After a Nuclear Disaster in Japan By Yuni Ikawati nuclear power technology continues to evolve. Not like in Chernobyl, nuclear power plants affected by the earthquake is now more resilient and able to anticipate the negligence of man as the operator. However, Fukushima case shows,…
Incubator Komodo, Like What Is
KOMPAS / HERU SRI Kumoro RELATED: Zeby Komodo Campaign incentive in the UAE Komodo Zeby Campaign in Abu Dhabi Six Endangered Komodo Paralyzed It Off < ; li> Wow … It's Finally 25 eggs hatched Komodo JAKARTA, KOMPAS.com – Now, dragons, dragons in Ragunan have an incubator. Not for the dragons, but for the eggs of native reptiles that Nusa Tenggara. Sunday (28/11/10), the incubator was officially used in Ragunan Zoo…
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AP Photo / Kyodo News Red Cross volunteers who had just returned from Fukushima scanned to ensure the presence or absence of exposure to nuclear radiation leaks from nuclear power plants.1 RELATED: WHO: More Dangers of Radiation Contaminated Food Indonesia Not Contaminated Fish Radiation Suicide Mission Workers Nuclear Reactor < ; li> Fukushima Nuclear Power Plant Is Closing Why I (Still) Surviving in Tokyo? Nawa Single —…
World's Smallest Electric Motor
The smallest electric motor1 – Scientists have created the world's smallest electric motor. Electric motor is made of one millionth of a meter-sized molecules. The work of these scientists published in the journal Nature Nanotechnology, Monday (04/09/2011). The smallest electric motor can later be instrumental in the medical world as well as the motor of one molecule nantoteknologi.Elektrik been made before, but this time the elec…
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AP PHOTO / NTV JAPAN VIA APTN Pictures taken from NTV television showed smoke billowing from the Fukushima Daiichi, a nuclear power plant (NPP) in Okumamachi, Fukushima Prefecture, Japan, Saturday (12 / 3). The roof and walls were cracked due to building nuclear plants the day before the earthquake shocks. Concerns arise due to leakage of nuclear radiation from nuclear reactors at the nuclear power plant.1 JAKARTA, – Hearing the news th…


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Madam VeronicaThe training of a new submissive.
Made to ServeMy Mistress makes my wife perform for our pleasure.
MadisonProfessor finds a submissive student.
Madison Discovers a New LifeShe loses a casino bet & is sold as a slave.
Maid For DessertMaster has his slave play maid and tease herself.
Maid in ChargeRich woman submits.
Maid ServiceAlyssa has a unique job interview.
Maids TurnaroundMaid Slave turns the tables on her Mistress.
Mail Order SlutMan orders an Asian mail order bride.


text:
Lane Medical Library
Recent Stanford Publications in PubMedSubscribe to Recent Stanford Publications in PubMed
- Genome Editing in Mouse Spermatogonial Stem/Progenitor Cells Using Engineered Nucleases.Fanslow DA, Wirt SE, Barker JC, Connelly JP, Porteus MH, Dann CTPLoS One
- Addressing the Knowledge Gap in Clinical Recommendations for Management and Complete Excision of Clinically Atypical Nevi/Dysplastic Nevi: Pigmented Lesion Subcommittee Consensus Statement.Kim CC, Swetter SM, Curiel-Lewandrowski C, Grichnik JM, Grossman D, Halpern AC, Kirkwood JM, Leachman SA, Marghoob AA, Ming ME, Nelson KC, Veledar E, Venna SS, Chen SCJAMA Dermatol
- RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation.Xue S, Tian S, Fujii K, Kladwang W, Das R, Barna MNature
- Functional transformations of odor inputs in the mouse olfactory bulb.Adam Y, Livneh Y, Miyamichi K, Groysman M, Luo L, Mizrahi AFront Neural Circuits
- Salt-Stress Regulation of Root System Growth and Architecture in Arabidopsis Seedlings.Duan L, Sebastian J, Dinneny JRMethods Mol Biol
- Strategies to Increase Genome Editing Frequencies and to Facilitate the Identification of Edited Cells.Porteus MMethods Mol Biol
- Using Phage Integrases in a Site-Specific Dual Integrase Cassette Exchange Strategy.Geisinger JM, Calos MPMethods Mol Biol
- GWAS identifies four novel eosinophilic esophagitis loci.Sleiman PM, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau K, Bredenoord AJ, Furuta GT, Spergel JM, Hakonarson HNat Commun
- False positive 18F-fluorodeoxyglucose positron emission tomography/computed tomography liver lesion mimicking metastasis in 2 patients with gastroesophageal cancer.Paudel N, Kunz PL, Poultsides GA, Koong AC, Chang DTPract Radiat Oncol
- Visible-light-enhanced gating effect at the LaAlO3/SrTiO3 interface.Lei Y, Li Y, Chen YZ, Xie YW, Chen YS, Wang SH, Wang J, Shen BG, Pryds N, Hwang HY, Sun JRNat Commun
- Perspective: Catch melanoma early.Swetter SM, Geller ACNature
- NEUROIMAGING AND THE FUTURE OF PERSONALIZED TREATMENT IN PSYCHIATRY.Etkin ADepress Anxiety
- Updated Field Synopsis and Systematic Meta-Analyses of Genetic Association Studies in Cutaneous Melanoma: The MelGene Database.Antonopoulou K, Stefanaki I, Lill CM, Chatzinasiou F, Kypreou K, Karagianni F, Athanasiadis E, Spyrou GM, Ioannidis JP, Bertram L, Evangelou E, Stratigos AJJ Invest Dermatol
- O-022 Integrin α4β7: Discovery of Gut-Restrictive Oral Peptide Antagonists that are Active in Murine Models of Inflammatory Bowel Disease.Larry M, Ashok B, Lu B, Genet Z, Vinh T, Natalie S, Herodion C, Brian F, Caiding X, Jennifer D, Thamil A, Aida H, Dinesh P, David LInflamm Bowel Dis
- Osteoclast Derivation from Mouse Bone Marrow.Tevlin R, McArdle A, Chan CK, Pluvinage J, Walmsley GG, Wearda T, Marecic O, Hu MS, Paik KJ, Senarath-Yapa K, Atashroo DA, Zielins ER, Wan DC, Weissman IL, Longaker MTJ Vis Exp
- Educating Health Care Professionals on Human Trafficking.Grace AM, Lippert S, Collins K, Pineda N, Tolani A, Walker R, Jeong M, Trounce MB, Graham-Lamberts C, Bersamin M, Martinez J, Dotzler J, Vanek J, Storfer-Isser A, Chamberlain LJ, Horwitz SMPediatr Emerg Care
- Adrenergic Receptor Genotype Influences Heart Failure Severity and β-Blocker Response in Children with Dilated Cardiomyopathy.Reddy S, Fung A, Manlhiot C, Tierney ES, Chung WK, Blume E, Kaufman BD, Goldmuntz E, Colan S, Mital SPediatr Res
- Effect of the alkali insertion ion on the electrochemical properties of nickel hexacyanoferrate electrodes.Lee HW, Pasta M, Wang RY, Ruffo R, Cui YFaraday Discuss
- Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation.Reinisch A, Etchart N, Thomas D, Hofmann NA, Fruehwirth M, Sinha S, Chan CK, Senarath-Yapa K, Seo E, Wearda T, Hartwig UF, Beham-Schmid C, Trajanoski S, Lin Q, Wagner W, Dullin C, Alves F, Andreeff M, Weissman IL, Longaker MT, Schallmoser K, Majeti R, Strunk DBlood
- Collaborative regression.Gross SM, Tibshirani RBiostatistics
- Bone Marrow Characteristics Associated with Changes in Infarct Size after STEMI: A Biorepository Evaluation from the CCTRN TIME Trial.Schutt RC, Trachtenberg B, Cooke JP, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao D, Bhatnagar A, Johnstone BH, Lai D, Resende M, Ebert RF, Wu JC, Sayre SL, Orozco A, Zierold C, Simari RD, Moyé L, Cogle CR, Taylor DCirc Res
Genome Editing in Mouse Spermatogonial Stem/Progenitor Cells Using Engineered Nucleases.
PLoS One. 2014;9(11):e112652
Authors: Fanslow DA, Wirt SE, Barker JC, Connelly JP, Porteus MH, Dann CT
Editing the genome to create specific sequence modifications is a powerful way to study gene function and promises future applicability to gene therapy. Creation of precise modifications requires homologous recombination, a very rare event in most cell types that can be stimulated by introducing a double strand break near the target sequence. One method to create a double strand break in a particular sequence is with a custom designed nuclease. We used engineered nucleases to stimulate homologous recombination to correct a mutant gene in mouse "GS" (germline stem) cells, testicular derived cell cultures containing spermatogonial stem cells and progenitor cells. We demonstrated that gene-corrected cells maintained several properties of spermatogonial stem/progenitor cells including the ability to colonize following testicular transplantation. This proof of concept for genome editing in GS cells impacts both cell therapy and basic research given the potential for GS cells to be propagated in vitro, contribute to the germline in vivo following testicular transplantation or become reprogrammed to pluripotency in vitro.
PMID: 25409432 [PubMed - as supplied by publisher]
Addressing the Knowledge Gap in Clinical Recommendations for Management and Complete Excision of Clinically Atypical Nevi/Dysplastic Nevi: Pigmented Lesion Subcommittee Consensus Statement.
JAMA Dermatol. 2014 Nov 19;
Authors: Kim CC, Swetter SM, Curiel-Lewandrowski C, Grichnik JM, Grossman D, Halpern AC, Kirkwood JM, Leachman SA, Marghoob AA, Ming ME, Nelson KC, Veledar E, Venna SS, Chen SC
Importance: The management of clinically atypical nevi/dysplastic nevi (CAN/DN) is controversial, with few data to guide the process. Management recommendations for DN with positive histologic margins were developed by the Delphi method to achieve consensus among members of the Pigmented Lesion Subcommittee (PLS) of the Melanoma Prevention Working Group (MPWG) after reviewing the current evidence.
Objectives: To outline key issues related to the management of CAN/DN: (1) biopsies of CAN and how positive margins arise, (2) whether incompletely excised DN evolve into melanoma, (3) current data on the outcomes of DN with positive histologic margins, (4) consensus recommendations, and (5) a proposal for future studies, including a large-scale study to help guide the management of DN with positive margins.
Evidence Review: The literature, including recent studies examining management and outcomes of DN with positive margins between 2009 to 2014, was reviewed.
Findings: A consensus statement by the PLS of the MPWG following review of the literature, group discussions, and a structured Delphi method consensus.
Conclusions and Relevance: This consensus statement reviews the complexities of management of CAN/DN. A review of the literature and 2 rounds of a structured Delphi consensus resulted in the following recommendations: (1) mildly and moderately DN with clear margins do not need to be reexcised, (2) mildly DN biopsied with positive histologic margins without clinical residual pigmentation may be safely observed rather than reexcised, and (3) observation may be a reasonable option for management of moderately DN with positive histologic margins without clinically apparent residual pigmentation; however, more data are needed to make definitive recommendations in this clinical scenario.
PMID: 25409291 [PubMed - as supplied by publisher]
RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation.
Nature. 2014 Nov 19;
Authors: Xue S, Tian S, Fujii K, Kladwang W, Das R, Barna M
Emerging evidence suggests that the ribosome has a regulatory function in directing how the genome is translated in time and space. However, how this regulation is encoded in the messenger RNA sequence remains largely unknown. Here we uncover unique RNA regulons embedded in homeobox (Hox) 5' untranslated regions (UTRs) that confer ribosome-mediated control of gene expression. These structured RNA elements, resembling viral internal ribosome entry sites (IRESs), are found in subsets of Hox mRNAs. They facilitate ribosome recruitment and require the ribosomal protein RPL38 for their activity. Despite numerous layers of Hox gene regulation, these IRES elements are essential for converting Hox transcripts into proteins to pattern the mammalian body plan. This specialized mode of IRES-dependent translation is enabled by an additional regulatory element that we term the translation inhibitory element (TIE), which blocks cap-dependent translation of transcripts. Together, these data uncover a new paradigm for ribosome-mediated control of gene expression and organismal development.
PMID: 25409156 [PubMed - as supplied by publisher]
Functional transformations of odor inputs in the mouse olfactory bulb.
Front Neural Circuits. 2014;8:129
Authors: Adam Y, Livneh Y, Miyamichi K, Groysman M, Luo L, Mizrahi A
Sensory inputs from the nasal epithelium to the olfactory bulb (OB) are organized as a discrete map in the glomerular layer (GL). This map is then modulated by distinct types of local neurons and transmitted to higher brain areas via mitral and tufted cells. Little is known about the functional organization of the circuits downstream of glomeruli. We used in vivo two-photon calcium imaging for large scale functional mapping of distinct neuronal populations in the mouse OB, at single cell resolution. Specifically, we imaged odor responses of mitral cells (MCs), tufted cells (TCs) and glomerular interneurons (GL-INs). Mitral cells population activity was heterogeneous and only mildly correlated with the olfactory receptor neuron (ORN) inputs, supporting the view that discrete input maps undergo significant transformations at the output level of the OB. In contrast, population activity profiles of TCs were dense, and highly correlated with the odor inputs in both space and time. Glomerular interneurons were also highly correlated with the ORN inputs, but showed higher activation thresholds suggesting that these neurons are driven by strongly activated glomeruli. Temporally, upon persistent odor exposure, TCs quickly adapted. In contrast, both MCs and GL-INs showed diverse temporal response patterns, suggesting that GL-INs could contribute to the transformations MCs undergo at slow time scales. Our data suggest that sensory odor maps are transformed by TCs and MCs in different ways forming two distinct and parallel information streams.
PMID: 25408637 [PubMed - as supplied by publisher]
Salt-Stress Regulation of Root System Growth and Architecture in Arabidopsis Seedlings.
Methods Mol Biol. 2015;1242:105-122
Authors: Duan L, Sebastian J, Dinneny JR
In order to acclimate to the soil environment, plants need to constantly optimize their root system architecture for efficient resource uptake. Roots are highly sensitive to changes in their surrounding environment and root system responses to a stress such as salinity and drought can be very dynamic and complex in nature. These responses can be manifested differentially at the cellular, tissue, or organ level and between the types of roots in a root system. Therefore, various approaches must be taken to quantify and characterize these responses. In this chapter, we review methods to study basic root growth traits, such as root length, cell cycle activity and meristem size, cell shape and size that form the basis for the emergent properties of the root system. Methods for the detailed analysis of lateral root initiation and postemergence growth are described. Finally, several live-imaging systems, which allow for dynamic imaging of the root, will be explored. Together these tools provide insight into the regulatory steps that sculpt the root system upon environmental change and can be used as the basis for the evaluation of genetic variation affecting these pathways.
PMID: 25408448 [PubMed - as supplied by publisher]
Strategies to Increase Genome Editing Frequencies and to Facilitate the Identification of Edited Cells.
Methods Mol Biol. 2015;1239:281-289
Authors: Porteus M
The power of genome editing is increasingly recognized as it has become more accessible to a wide range of scientists and a wider range of uses has been reported. Nonetheless, an important practical aspect of the strategy is develop methods to increase the frequency of genome editing or methods that enrich for genome-edited cells such that they can be more easily identified. This chapter discusses several different approaches including the use of cold-shock, exonucleases, surrogate markers, specialized donor vectors, and oligonucleotides to enhance the frequency of genome editing or to facilitate the identification of genome-edited cells.
PMID: 25408413 [PubMed - as supplied by publisher]
Using Phage Integrases in a Site-Specific Dual Integrase Cassette Exchange Strategy.
Methods Mol Biol. 2015;1239:29-38
Authors: Geisinger JM, Calos MP
ΦC31 integrase, a site-specific large serine recombinase, is a useful tool for genome engineering in a variety of eukaryotic species and cell types. ΦC31 integrase performs efficient recombination between its attB site and either its own placed attP site or a partially mismatched genomic pseudo attP site. Bxb1 integrase, another large serine recombinase, has a similar level of recombinational activity, but recognizes only its own attB and attP sites. Previously, we have used these integrases sequentially to integrate plasmid DNA into the genome. This approach relied on placing a landing pad attP for Bxb1 integrase in the genome by using phiC31 integrase-mediated recombination at a genomic pseudo attP site. In this chapter, we present a protocol for using these integrases simultaneously to facilitate cassette exchange at a predefined location. This approach permits greater control and accuracy over integration. We also present a general method for using polymerase chain reaction assays to verify that the desired cassette exchange occurred successfully.
PMID: 25408400 [PubMed - as supplied by publisher]
GWAS identifies four novel eosinophilic esophagitis loci.
Nat Commun. 2014;5:5593
Authors: Sleiman PM, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau K, Bredenoord AJ, Furuta GT, Spergel JM, Hakonarson H
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by infiltration of the oesophagus with eosinophils. We had previously reported association of the TSLP/WDR36 locus with EoE. Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14, that encodes a calpain whose expression is highly enriched in the oesophagus. The identification of five EoE loci, not only expands our aetiological understanding of the disease but may also represent new therapeutic targets to treat the most debilitating aspect of EoE, oesophageal inflammation and remodelling.
PMID: 25407941 [PubMed - as supplied by publisher]
False positive 18F-fluorodeoxyglucose positron emission tomography/computed tomography liver lesion mimicking metastasis in 2 patients with gastroesophageal cancer.
Pract Radiat Oncol. 2014;4(6):368-371
Authors: Paudel N, Kunz PL, Poultsides GA, Koong AC, Chang DT
PMID: 25407856 [PubMed - as supplied by publisher]
Visible-light-enhanced gating effect at the LaAlO3/SrTiO3 interface.
Nat Commun. 2014;5:5554
Authors: Lei Y, Li Y, Chen YZ, Xie YW, Chen YS, Wang SH, Wang J, Shen BG, Pryds N, Hwang HY, Sun JR
Electrostatic gating field and light illumination are two widely used stimuli for semiconductor devices. Via capacitive effect, a gate field modifies the carrier density of the devices, while illumination generates extra carriers by exciting trapped electrons. Here we report an unusual illumination-enhanced gating effect in a two-dimensional electron gas at the LaAlO3/SrTiO3 interface, which has been the focus of emergent phenomena exploration. We find that light illumination decreases, rather than increases, the carrier density of the gas when the interface is negatively gated through the SrTiO3 layer, and the density drop can be 20 times as large as that caused by the conventional capacitive effect. This effect is further found to stem from an illumination-accelerated interface polarization, an originally extremely slow process. This unusual effect provides a promising controlling of the correlated oxide electronics in which a much larger gating capacity is demanding due to their intrinsic larger carrier density.
PMID: 25407837 [PubMed - as supplied by publisher]
Perspective: Catch melanoma early.
Nature. 2014 Nov 19;515(7527):S117
Authors: Swetter SM, Geller AC
PMID: 25407708 [PubMed - as supplied by publisher]
Depress Anxiety. 2014 Nov;31(11):899-901
Authors: Etkin A
PMID: 25407576 [PubMed - as supplied by publisher]
Updated Field Synopsis and Systematic Meta-Analyses of Genetic Association Studies in Cutaneous Melanoma: The MelGene Database.
J Invest Dermatol. 2014 Nov 19;
Authors: Antonopoulou K, Stefanaki I, Lill CM, Chatzinasiou F, Kypreou K, Karagianni F, Athanasiadis E, Spyrou GM, Ioannidis JP, Bertram L, Evangelou E, Stratigos AJ
We updated a field synopsis of cutaneous melanoma (CM) genetics by systematically retrieving and combining data from genetic association studies published as of August 31, 2013. Data were available from 197 studies, which included 83,343 CM cases and 187,809 controls and reported on 1,126 polymorphisms in 289 different genes. Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 datasets confirmed 20 SNPs across ten loci (TYR, AFG3L1P, CDK10, MYH7B, SLC45A2, MTAP, ATM, CLPTM1L, FTO and CASP8) that have previously been published with genome-wide significant evidence for association (P<5 × 10(-8)) with CM risk, with certain variants possibly functioning as proxies of already tagged genes. Four other loci (MITF, CCND1, MX2, PLA2G6) were also significantly associated with 5 × 10(-8)<P<1 × 10(-3). In supplementary meta-analyses derived from GWAS, one additional locus located 11 kb upstream of ARNT (chromosome 1q21) showed genome-wide statistical significance with CM. Our approach serves as a useful model in analyzing and integrating the reported germline alterations involved in CM.Journal of Investigative Dermatology accepted article preview online, 19 November 2014. doi:10.1038/jid.2014.491.
PMID: 25407435 [PubMed - as supplied by publisher]
O-022 Integrin α4β7: Discovery of Gut-Restrictive Oral Peptide Antagonists that are Active in Murine Models of Inflammatory Bowel Disease.
Inflamm Bowel Dis. 2014 Dec;20 Suppl 1:S14
Authors: Larry M, Ashok B, Lu B, Genet Z, Vinh T, Natalie S, Herodion C, Brian F, Caiding X, Jennifer D, Thamil A, Aida H, Dinesh P, David L
BACKGROUND:: The α4β7 integrin is a clinically validated target for inflammatory bowel disease (IBD). The anti-α4β7 antibody vedolizumab is approved by the FDA for treating moderate-to-severe ulcerative colitis and Crohn's disease. Vedolizumab binds to α4β7 on circulating memory/effector T cells in the blood and blocks their homing to intestinal tissues expressing the ligand MAdCAM-1. The aim of this study is to develop orally stable α4β7 antagonist peptides that act locally in the intestinal tissue. These peptides have minimal systemic exposure, yet are effective in blocking T cell homing and are efficacious in murine models of IBD.
METHODS:: Potent, selective and orally stable peptide antagonists of α4β7 integrin were identified through Protagonist's peptide and peptidomimetic technology platform. To evaluate oral stability, the peptides were incubated in a variety of ex vivo intestinal/colonic washes or simulated gastric/intestinal fluids, and half-lives determined by mass spectrometry. Pharmacokinetic (PK), pharmacodynamic (PD) and chronic colitis studies were conducted in mice.
RESULTS:: The peptides are potent against α4β7, but not α4β1 and αLβ2 as measured in biochemical and cell adhesion assays. In α4β7 specific cell adhesion assays, the peptides block adhesion of the human RPMI 8866 cell line (B cell lymphoblastoid) or mouse TK-1 (T cell lymphoblast) to immobilized MAdCAM-1 (IC50 < 20 nM). In the α4β1 or αLβ2 specific cell adhesion assay using human Jurkat cells, they are inactive up to the highest tested concentration, 100 μM. To facilitate oral delivery, we chemically engineered the peptides to be resistant to chemical and proteolytic degradation in a variety of gastric and intestinal fluids, while maintaining their potency and selectivity. PK studies in normal or dextran sodium sulfate (DSS) treated mice and rats showed that oral dosing results in exposure in the small intestine, colon and mesenteric lymph nodes (MLN), but no significant measurable levels in the blood and urine. A PD assay was used to assess the effect of oral dosing on trafficking of endogenous memory T cells in the mouse. Mice treated with DSS were orally dosed daily with peptides for 9 or 13 days, and harvested tissues were analyzed by FACS. FACS analysis of tissues from animals dosed with peptides showed that there is a reduction of CD4 CD44 CD45RB β7 T cells in the MLN and Peyer's Patches, but not in the spleen or blood. There was also marked reduction of clinical disease symptoms. We also evaluated these peptides in a T cell adoptive transfer chronic colitis model. Daily oral dosing with peptides reduced the severity of disease as measured by colon weight length ratio and histology.
CONCLUSIONS:: Potent, selective and orally stable peptide antagonists of α4β7 integrin were shown in oral PK studies to have significant exposure in intestinal tissues, but not blood and urine. Despite low blood exposure, these peptides block T cell homing to gut associated lymphoid tissue and attenuate disease in murine models of IBD. These results support the therapeutic potential of locally blocking T cell homing while minimizing immunogenicity and the risk of opportunistic infections associated with systemically delivered immunosuppressants and biologics.
PMID: 25407177 [PubMed - as supplied by publisher]
Osteoclast Derivation from Mouse Bone Marrow.
J Vis Exp. 2014;(93)
Authors: Tevlin R, McArdle A, Chan CK, Pluvinage J, Walmsley GG, Wearda T, Marecic O, Hu MS, Paik KJ, Senarath-Yapa K, Atashroo DA, Zielins ER, Wan DC, Weissman IL, Longaker MT
Osteoclasts are highly specialized cells that are derived from the monocyte/macrophage lineage of the bone marrow. Their unique ability to resorb both the organic and inorganic matrices of bone means that they play a key role in regulating skeletal remodeling. Together, osteoblasts and osteoclasts are responsible for the dynamic coupling process that involves both bone resorption and bone formation acting together to maintain the normal skeleton during health and disease. As the principal bone-resorbing cell in the body, changes in osteoclast differentiation or function can result in profound effects in the body. Diseases associated with altered osteoclast function can range in severity from lethal neonatal disease due to failure to form a marrow space for hematopoiesis, to more commonly observed pathologies such as osteoporosis, in which excessive osteoclastic bone resorption predisposes to fracture formation. An ability to isolate osteoclasts in high numbers in vitro has allowed for significant advances in the understanding of the bone remodeling cycle and has paved the way for the discovery of novel therapeutic strategies that combat these diseases. Here, we describe a protocol to isolate and cultivate osteoclasts from mouse bone marrow that will yield large numbers of osteoclasts.
PMID: 25407120 [PubMed - as supplied by publisher]
Educating Health Care Professionals on Human Trafficking.
Pediatr Emerg Care. 2014 Nov 18;
Authors: Grace AM, Lippert S, Collins K, Pineda N, Tolani A, Walker R, Jeong M, Trounce MB, Graham-Lamberts C, Bersamin M, Martinez J, Dotzler J, Vanek J, Storfer-Isser A, Chamberlain LJ, Horwitz SM
BACKGROUND: The US Department of State estimates that there are between 4 and 27 million individuals worldwide in some form of modern slavery. Recent studies have demonstrated that 28% to 50% of trafficking victims in the United States encountered health care professionals while in captivity, but were not identified and rescued. This study aimed to determine whether an educational presentation increased emergency department (ED) providers' recognition of human trafficking (HT) victims and knowledge of resources to manage cases of HT.
METHODS: The 20 largest San Francisco Bay Area EDs were randomized into intervention (10 EDs) or delayed intervention comparison groups (10 EDs) to receive a standardized educational presentation containing the following: background about HT, relevance of HT to health care, clinical signs in potential victims, and referral options for potential victims. Participants in the delayed intervention group completed a pretest in the period the immediate intervention group received the educational presentation, and all participants were assessed immediately before (pretest) and after (posttest) the intervention. The intervention effect was tested by comparing the pre-post change in the intervention group to the change in 2 pretests in the delayed intervention group adjusted for the effect of clustering within EDs. The 4 primary outcomes were importance of knowledge of HT to the participant's profession (5-point Likert scale), self-rated knowledge of HT (5-point Likert scale), knowledge of who to call for potential HT victims (yes/no), and suspecting that a patient was a victim of HT (yes/no).
FINDINGS: There were 258 study participants from 14 EDs; 141 from 8 EDs in the intervention group and 117 from 7 EDs in the delayed intervention comparison group, of which 20 served as the delayed intervention comparison group. Participants in the intervention group reported greater increases in their level of knowledge about HT versus those in the delayed intervention comparison group (1.42 vs -0.15; adjusted difference = 1.57 [95% confidence interval, 1.02-2.12]; P < 0.001). Pretest ratings of the importance of knowledge about HT to the participant's profession were high in both groups and there was no intervention effect (0.31 vs 0.55; -0.24 [-0.90-0.42], P = 0.49). Knowing who to call for potential HT victims increased from 7.2% to 59% in the intervention group and was unchanged (15%) in the delayed intervention comparison group (61.4% [28.5%-94.4%]; P < 0.01). The proportion of participants who suspected their patient was a victim of HT increased from 17% to 38% in the intervention group and remained unchanged (10%) in the delayed intervention comparison group (20.9 [8.6%-33.1%]; P < 0.01).
INTERPRETATION: A brief educational intervention increased ED provider knowledge and self-reported recognition of HT victims.
PMID: 25407038 [PubMed - as supplied by publisher]
Adrenergic Receptor Genotype Influences Heart Failure Severity and β-Blocker Response in Children with Dilated Cardiomyopathy.
Pediatr Res. 2014 Nov 19;
Authors: Reddy S, Fung A, Manlhiot C, Tierney ES, Chung WK, Blume E, Kaufman BD, Goldmuntz E, Colan S, Mital S
BackgroundAdrenergic receptor (ADR) genotypes are associated with heart failure (HF) and β-blocker response in adults. We assessed the influence of ADR genotypes in children with dilated cardiomyopathy (DCM).Methods91 children with advanced DCM and 44 with stable DCM were genotyped for 3 ADR genotypes associated with HF risk in adults: α2cdel322-325, β1Arg389, and β2Arg16. Data were analyzed by genotype and β-blocker use. Mean age at enrollment was 8.5 years.ResultsOne-year event-free survival was 51% in advanced and 80% in stable DCM. High-risk genotypes were associated with higher left ventricular (LV) filling pressures, higher systemic and pulmonary vascular resistance, greater decline in LV ejection fraction (p<0.05), and a higher frequency of mechanical circulatory support while awaiting transplant (p=0.05). While β-blockers did not reduce heart failure severity in the overall cohort, in the subset with multiple high-risk genotypes, those receiving β-blockers showed better preservation of cardiac function and hemodynamics compared to those not receiving β-blockers (interaction p<0.05).ConclusionOur study identifies genetic risk markers that may help in the identification of patients at risk for developing decompensated HF and who may benefit from early institution of β-blocker therapy before progression to decompensated HF.Pediatric Research (2014); doi:10.1038/pr.2014.183.
PMID: 25406899 [PubMed - as supplied by publisher]
Effect of the alkali insertion ion on the electrochemical properties of nickel hexacyanoferrate electrodes.
Faraday Discuss. 2014 Nov 14;
Authors: Lee HW, Pasta M, Wang RY, Ruffo R, Cui Y
Nickel hexacyanoferrate (NiHCFe) is an attractive cathode material in both aqueous and organic electrolytes due to a low-cost synthesis using earth-abundant precursors and also due to its open framework, Prussian blue-like crystal structure that enables ultra-long cycle life, high energy efficiency, and high power capability. Herein, we explored the effect of different alkali ions on the insertion electrochemistry of NiHCFe in aqueous and propylene carbonate-based electrolytes. The large channel diameter of the structure offers fast solid-state diffusion of Li(+), Na(+), and K(+) ions in aqueous electrolytes. However, all alkali ions in organic electrolytes and Rb(+) and Cs(+) in aqueous electrolytes show a quasi-reversible electrochemical behavior that results in poor galvanostatic cycling performance. Kinetic regimes in aqueous electrolyte were also determined, highlighting the effect of the size of the alkali ion on the electrochemical properties.
PMID: 25406368 [PubMed - as supplied by publisher]
Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation.
Blood. 2014 Nov 18;
Authors: Reinisch A, Etchart N, Thomas D, Hofmann NA, Fruehwirth M, Sinha S, Chan CK, Senarath-Yapa K, Seo E, Wearda T, Hartwig UF, Beham-Schmid C, Trajanoski S, Lin Q, Wagner W, Dullin C, Alves F, Andreeff M, Weissman IL, Longaker MT, Schallmoser K, Majeti R, Strunk D
In the last decade there has been a rapid expansion in clinical trials using mesenchymal stromal cells (MSCs) from a variety of tissues. However, despite similarities in morphology, immunophenotype and differentiation behavior in vitro, MSCs sourced from distinct tissues do not necessarily have equivalent biological properties. We performed a genome-wide methylation, transcription and in vivo evaluation of MSCs from human bone marrow (BM), white adipose tissue, umbilical cord and skin cultured in humanized media. Surprisingly, only BM-derived MSCs spontaneously formed a bone marrow cavity through a vascularized cartilage intermediate in vivo that was progressively replaced by hematopoietic tissue and bone. Only BM-derived MSCs exhibited a chondrogenic transcriptional program with hypomethylation and increased expression of RUNX3, RUNX2, BGLAP, MMP13 and ITGA10 consistent with a latent and primed skeletal developmental potential. The humanized MSC-derived microenvironment permitted homing and maintenance of long-term murine SLAM(+) hematopoietic stem cells (HSCs) as well as human CD34(+)/CD38(-)/CD90(+)/CD45RA(+) HSCs after cord blood transplantation. These studies underscore the profound differences in developmental potential between MSC sources independent of donor age with implications for their clinical use. We also demonstrate a tractable human niche model for studying homing and engraftment of human hematopoietic cells in normal and neoplastic states.
PMID: 25406351 [PubMed - as supplied by publisher]
Collaborative regression.
Biostatistics. 2014 Nov 17;
Authors: Gross SM, Tibshirani R
We consider the scenario where one observes an outcome variable and sets of features from multiple assays, all measured on the same set of samples. One approach that has been proposed for dealing with these type of data is "sparse multiple canonical correlation analysis" (sparse mCCA). All of the current sparse mCCA techniques are biconvex and thus have no guarantees about reaching a global optimum. We propose a method for performing sparse supervised canonical correlation analysis (sparse sCCA), a specific case of sparse mCCA when one of the datasets is a vector. Our proposal for sparse sCCA is convex and thus does not face the same difficulties as the other methods. We derive efficient algorithms for this problem that can be implemented with off the shelf solvers, and illustrate their use on simulated and real data.
PMID: 25406332 [PubMed - as supplied by publisher]
Bone Marrow Characteristics Associated with Changes in Infarct Size after STEMI: A Biorepository Evaluation from the CCTRN TIME Trial.
Circ Res. 2014 Nov 18;
Authors: Schutt RC, Trachtenberg B, Cooke JP, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao D, Bhatnagar A, Johnstone BH, Lai D, Resende M, Ebert RF, Wu JC, Sayre SL, Orozco A, Zierold C, Simari RD, Moyé L, Cogle CR, Taylor D
Rationale: Despite significant interest in bone marrow mononuclear cell (BMC) therapy for ischemic heart disease, current techniques have resulted in only modest benefits. However, select patients have shown improvements after autologous BMC therapy, but the contributing factors are unclear. Objective: The purpose of this study was to identify BMC characteristics associated with a reduction in infarct size following STEMI. Methods and Results: This prospective study comprised patients consecutively enrolled in the CCTRN TIME trial who agreed to have their BMCs stored and analyzed at the CCTRN Biorepository. Change in infarct size between baseline (3 days after percutaneous coronary intervention) and 6-month follow-up was measured by cardiac magnetic resonance imaging (cMRI). Infarct-size measurements and BMC phenotype and function data were obtained for 101 patients (mean age, 56.5 years; mean screening ejection fraction, 37%; mean baseline cMRI ejection fraction, 45%). At 6 months, 75 patients (74.3%) showed a reduction in infarct size (mean change, -21.0%±17.6%). Multiple regression analysis indicated that infarct size reduction was greater in patients who had a larger percentage of CD31+ BMCs (P=0.046) and in those with faster BMC growth rates in CFU-Hill and ECFC functional assays (P=0.033 and P=0.032, respectively). Conclusions: This study identified BMC characteristics associated with a better clinical outcome in patients with STEMI and highlighted the importance of endothelial precursor activity in regenerating infarcted myocardium. Furthermore, it suggests that for these STEMI patients, myocardial repair was more dependent on baseline BMC characteristics than on whether the patient underwent intracoronary BMC transplantation.
PMID: 25406300 [PubMed - as supplied by publisher]
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text:
10 problems with EOBRs
These problems are among many noted by frequent Overdrive commenter E.F. McHenry as Congress considered an EOBR mandate ultimately included in the MAP-21 highway bill.
Amendment seeks to curtail EPA oversight of fuel standards
A House committee may consider an amendment to prevent the EPA from regulating fuel and emission standards in trucks.
Would the professional drivers please raise hands?
At a fueling station in Dayton, Ohio, Kevin Burch, President of the Jet Express truck line, saw a decal (pictured) on the side of a flatbed as he was fueling. The message, "This truck helps ...
Owner-operators back in the news on EOBRs
The latest is following the Federal Motor Carrier Safety Administration's formal removal of the remedial-directive rule, which would have required carriers with big hours compliance problems to install electronic onboard recorders. After being thrown out ...
UV protection and FMCSA's window-tinting clarification
FMCSA said that "truck drivers, fleet owners and managers can install a protective window film with over 70 percent net Visible Light Transmittance (VLT) on the side windows of trucks weighing over 26,001 pounds."
$100 off apnea test; Motorhead Garage TV at Diamond International
Motorhead Garage TV to feature International dealerships this morning Diamond Companies, a holding company for International Truck and IC Bus dealerships in Tennessee, Arkansas, Missouri and Kansas, will be featured on a special "Big Rig" episode of ...
Speak out today in EOBR session
If you've not taken the opportunity to tell the Federal Motor Carrier Safety Administration your thoughts on just how electronic onboard recorders for hours-of-service monitoring are or will be used in the industry, today is ...
Red alert: Get your uniform or else!
Now that the Federal Motor Carrier Safety Administration has begun to reach its long regulatory arm into your daily dress, drivers are sounding off in record numbers. "This is just taking it too far," said owner-operator ...
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text:
May 16, 2013
By Evan Lockridge
Building of new homes in the United States fell in April to its lowest level since November, but the rate is still well above the same time a year ago, and new building permits are at their highest level since June 2008.
The U.S. Commerce Department reports new home starts fell 16.5% in April from the month before to an annual rate of 853.000. The decline was due largely to a 37.8% drop in the building of structures with at least five homes. Single-family home construction fell only 2.1%.
The drop was not surprising to analysts after the big jump seen in March.
Compared to April of last year, total home construction starts last month are up 13.1%, while new building permits issued are up 35.8%.
Despite the April downturn from March, homebuilders are feeling optimistic about the future.
A sign of future building activity for residences, new building permits issued, increased 14.3% in April from March to an annual rate of 1.02 million, the highest level since June 2008.
The National Association of Homebuilders monthly index of builder confidence, released Wednesday, shows expectations for future sales hit its highest level this month since February 2007.
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Celebrity Cafe
January 21, 2013 | by Janet Donovan
Photo by Brendan Kownacki
Who knew that Tina Brown, editor-in-chief of The Daily Beast and Newsweek, was so comical. She either borrowed one of Letterman's joke writers or it comes naturally. Either way, she was a comic hit at the bi-partisan Inaugural brunch she hosted at Cafe Milano sponsored by Credit Suisse.
"Welcome," she said, "to the Daily Beast Newsweek bi-partisan brunch where democrats, republicans and their food tasters all sit down together."


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Chad Michael Murray Set as Male Lead in ABC's Natalie Portman-Produced Pilot 'Scruples'
The former "One Tree Hill" actor will play a photographer at the fashion endeavor at the center of the drama pilot from Bob Brush and Mel Harris.
Chad Michael Murray is plotting his series TV return.
The former One Tree Hill star has been cast as the male lead in ABC's drama pilot Scruples, The Hollywood Reporter has learned.
Based on the Judith Krantz novel, the sexy soap is set in the late 1970s and follows Billy (Claire Forlani), a socialite who, following her husband's death, seeks to open a fashion-forward boutique in the heart of Beverly Hills.
Undercovers' Boris Kodjoe plays Billy's ex-husband's attorney. Murray will play Spider Elliott, a handsome photographer and partner in Billy's fashion endeavor. Pan Am's Karinne Vanasse will guest star in the pilot as a designer named Valentine, with an option to become a regular should the drama go to pilot. The role is in second position to Pan Am.
Bob Brush and Mel Harris will pen the pilot and executive produce alongside Tony Krantz, Annette Savitch and Natalie Portman. Michael Sucsy is on board to direct the pilot, which hails from Warner Bros. Television.
Barry Bostwick played the role opposite Lindsay Wagner in the 1980 CBS miniseries based on Krantz's book.
For Murray, the role would mark his return to series television after the CW's One Tree Hill, which he departed following its sixth season. He reprised his role as Lucas Scott in a February episode of the CW series' ninth and final season.
Repped by WME, Brillstein Entertainment and Felker Toczek, Murray since departing One Tree Hill has been focused on features including Home of the Brave, House of Wax, A Cinderella Story and Freaky Friday.
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MJM is the best magic supplier there is! My order arrived in just a few days, and now I'm getting 10% percent off on all of my purchases. MJM has...Read More ->


text:
Seasonal delights, sights and sounds of Christmas come alive, December 10-13th, 2014 in beautiful Pigeon Forge, TN.
Join your host band, Lorraine Jordan and the Carolina Road Band for Bluegrass Christmas in the Smokies!
"Pigeon Forge is a wonderful holiday destination to share with your family and friends," commented the Lady of Tradition, Lorraine Jordan. "We're thrilled to bring you an exciting lineup of musicians and special guests again this year. Join us as we make special holiday music and memories!"
Santa Claus and Lorraine Jordan of
Carolina Road in beautiful Pigeon Forge.
Click here to listen to Christmas in the Smokies!
Lorraine Jordan and Carolina Road are proud to support Guitars for Soldiers with the purchase and donation of four Gupit guitars, recently.
"The band and I owe a debt of gratitude to our fans," said Lorraine Jordan of Carolina Road. "Through the generosity of donations received at the Christmas in the Smokies Festival 2013, we were able to purchase four Cupit guitars with cases for our service people. This is a wonderful opportunity for us to show our appreciation and give back to those who do so much for us!"
For more information, please visit, GuitarsFORSOLDIERS.com
Dates, Times, and Bands are subject to change.
Wednesday Dec 10
7:00 The VW Boys
8:00 Christmas In The Smokies All Star Jam
Thursday Dec 11
3:00 Open Mic
3:30 Goldwing Express
5:00 Ralph Stanley II
6:30 Sideline
8:00 Lorraine Jordan & Carolina Road
9:30 Doyle Lawson & Quicksilver
Friday Dec 12
1:00 The Hart Brothers
2:30 Chris Jones & The Night Drivers
4:00 The Gary Waldrep Band
5:30 The Bluegrass Mountaineers
7:00 Lorraine Jordan & Carolina Road with Special Guests:
James King & Tim Cifers
8:30 Old Friend's Doyle Lawson, JD Crowe & Paul Williams
Saturday Dec 13
11:00 The Roys
12:30 Nu-Blu
2:00 Idletymes
3:30 Goldwing Express
5:00 Williamson Branch
6:00 The Gentlemen Of Bluegrass
7:30 The James King Band with guest Col. Issac Moore
9:00 Lorraine Jordan & Carolina Road
End of Show - See You In 2015!!!
Ramada Inn & Smoky Mountain Convention Center
4010 ParkwayPigeon Forge, Tennessee 37863
Non Smoking Rooms
Smoking Rooms
Pet Friendly Rooms
Jacuzzi Rooms
Family Suites
Two-Bedroom Suites
Ramada Inn Rooms Per Night
Monday - Thursday....$61.68 per night
Friday - Saturday....$72.91 per night
Directions:I-40 exit 407 (Rt. 66 to Sevierville)Hwy 441 in Pigeon Forge
on Pigeon Forge PkwyJust past red light #8 on the right behind KFC
There are alternate hotels in the same area.
Rodeway Inn Mountain SkysAll Season SuitesCountry CascadesCreekstone InnGovernor's Inn
The Resort at Governor's Crossing
For more hotel information, please visit www.smokymountainresorts.com.
Call the Smoky Mountain Resorts
now at 1-800-223-6707
to book your room for the festival.
Be sure to ask for the bluegrass
room rate when booking.
Looking for the perfect
Christmas Gift or Stocking Stuffer
for your favorite Bluegrass Fan?
Contact the Festival Promoter:
Jordan Entertainment
101 Timber Pointe Ln, Garner, NC 27529
Phone: 919.779.5672
Contact the Ramada Inn & Smoky Mountain Convention Center:
4010 Parkway Pigeon Forge, Tennessee 37863
Tel: 1-800-223-6707
Click here for the 2014 Vendor Application
December 10-13, 2014 Pigeon Forge, TN
Ramada Inn & Smoky Mountain Convention Center


text:
Family Research Council (FRC) president Tony Perkins has all but ceased to appear as a guest on CNN and MSNBC. It's a dramatic change for the anti-gay hate group leader, whose constant appearances on cable news during the 2012 GOP primary cycle drew criticism from progressive faith groups.
Since becoming president of the Family Research Council in 2003, Perkins has used his position as a leader among social conservatives to command significant media attention. FRC hosts the annual Values Voters Summit, making Perkins an easy choice for networks looking for a prominent voice to comment on social conservatism and GOP politics.
Over time, networks also began turning to Perkins for commentary on LGBT issues like the fight over marriage equality and the repeal of "Don't Ask, Don't Tell." Perkins was happy to oblige - he has a history of making incendiary comments about LGBT people, and FRC has turned the production of anti-gay propaganda into an art form.
In 2010, the Southern Poverty Law Center labeled FRC an anti-gay "hate group," citing the organization's propagation of known falsehoods about LGBT people.
That label, unfortunately, didn't stop cable news networks from continuing to invite Perkins on national television on behalf of social conservatives. During the 2012 Republican presidential primary season, Perkins appeared on CNN, MSNBC, and Fox News a total of 56 times. MSNBC was particularly friendly to Perkins, with Hardball host Chris Matthews praising Perkins as an "honest conservative" who always tried "to find the truth" during a November 2011 interview:
Perkins' platform on cable news didn't sit well with audiences familiar with his long and sordid history of bigoted anti-LGBT rhetoric. Faithful America, a progressive Christian group dedicated to "reclaiming Christianity from the religious right," launched a petition in February 2012 asking the network to stop inviting Perkins on air. The petition garnered 20,000 signatures, which were delivered to MSNBC's headquarters.
Perkins' platform at MSNBC created an awkward situation for Hardball host Chris Matthews. At a March 2012 book event, Matthews was asked about his willingness to invite Perkins on his show and admitted that his critics "may be right." At a book signing a few weeks later, Matthews told Faithful America members that the group had "a good argument" for no longer hosting Perkins." Perkins did appear on Hardball once more, in a joint appearance with gay Rep. Barney Frank (D-MA. But rather than offer the warm welcome Perkins had come to expect, Matthews grilled Perkins on his anti-LGBT extremism.
In the summer of 2013, Faithful America launched a similar petition targeting CNN after the network hosted Perkins to discuss the Supreme Court's ruling on Section 3 of the Defense of Marriage Act (DOMA). The petition urged CNN not to let Perkins "speak on behalf of America's Christians" and quickly gathered more than 32,000 signatures.
A new Equality Matters analysis finds that both MSNBC and CNN have largely ended their practice of hosting Perkins in the months since the end of the 2012 GOP primary. Perkins hasn't appeared on MSNBC since March 2013, when the Supreme Court heard arguments in two marriage equality cases. Meanwhile, Perkins' appearances on CNN have steadily declined in the last year, and he hasn't been on the network since February: At Fox News, on the other hand, Perkins' appearances have held steady and actually increased in the past year:
Family Research Council (FRC) president Tony Perkins has appeared significantly less frequently on CNN and MSNBC in the wake of petitions calling on the networks to stop hosting him. Perkins, whose organization has been labeled an anti-gay "hate group," continues to appear frequently on Fox News.
The globe recently experienced the hottest June on record, fitting in with the trend of global warming. Yet several top media outlets reported on the announcement without mentioning climate change at all.
2014 has been a record-breaking year for global temperatures. On July 21, the National Oceanic and Atmospheric Association announced that the average global temperature for the month of June was the hottest experienced for 134 years of records. This finding follows the hottest May on record, the hottest March to June period on record, and the third hottest first half of the year on record. The average ocean surface temperatures for the month of June were the warmest on record for any month of the year. NOAA's climate monitoring chief Derek Arndt explained succinctly to the Associated Press -- the only top U.S. print source* that reported on the findings in the context of global warming -- stating that the planet is in the "steroid era of the climate system." Climate scientist Jonathan Overpeck added: "This is what global warming looks like."
But if you consume mainstream media, you likely missed this context. CBS, NBC, MSNBC, USA Today, the Wall Street Journal,** and The Washington Post's Capital Weather Gang all covered the announcement without mentioning its key context: global warming, driven by human activities, is making hotter temperatures the norm.
The July 21 edition of ABC's World News With Diane Sawyer was the only broadcast network program to report on the record in the context of global warming, introducing it as "a new statistic for arguments about climate change," and going on to discuss extreme weather events currently happening across the United States:
A new profile of Larry Pratt, the odious executive director of fringe group Gun Owners of America (GOA) documents Pratt's lengthy history of extremism while noting that he is still treated by media as an authority in the gun debate.
The Pratt profile, authored by The American Independent Institute (TAII) fellow Alexander Zaitchik, was published July 14 as part of a RollingStone.com package, "America's Gun Violence Epidemic." Other articles in the series include an interview with former New York City mayor and gun violence prevention advocate Michael Bloomberg, a message from Richard Martinez, whose son was murdered in the recent Isla Vista, California mass shooting, stories from gunshot wound survivors, and an interactive map on gun violence in America.
Interspersed with accounts of Pratt's association with anti-Semitic and white supremacist groups, his call for the quarantine of AIDS victims, his support for the death squads of a genocidal dictator, and his longstanding engagement with bizarre anti-government conspiracy theories, Zaitchik recounts how Pratt is regularly called on by mainstream media outlets to participate in the debate over gun laws.
Indeed, a Media Matters analysis of cable news and major newspapers finds that media regularly turns to Pratt despite his place in the far-right wing fringe. Since the December 2012 mass shooting at Sandy Hook Elementary School in Newtown, Connecticut, Pratt has appeared during evening and Sunday programming on CNN seven times and three times each on MSNBC and Fox News.
From the July 10 edition of MSNBC's The Ed Show:
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A landmark new study finds that children of same-sex couples are happier and healthier than children raised by heterosexual parents - a finding that major media outlets have largely ignored despite its potential significance in the legal fight for marriage equality.
On July 4, researchers at the University of Melbourne unveiled the results of a study that looked at how children of same-sex and heterosexual couples fare on a variety of health and wellness measures. The Australian Study of Child Health in Same-Sex Families (ACHESS) is the largest study of its kind to date. Controlling for factors like socioeconomic status and parental education, researchers examined 500 children of 315 same-sex parents. An estimated 80 percent of the children were raised by female parents, with 18 percent raised by male parents. The Guardian summarized the researchers' findings:
The children raised by same-sex partners scored an average of 6% higher than the general population on measures of general health and family cohesion. They were equivalent to those from the general population on measures of temperament and mood, behavior, mental health and self-esteem.
Researchers did identify one hurdle often confronted by children of same-sex parents: anti-LGBT stigma, which about two-thirds of the children reported experiencing.
The Australian study is noteworthy not only given its unprecedented size and scope, but also because of its potential significance in the ongoing legal fight for marriage equality.
From the July 9 edition of MSNBC's The Ed Show:
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MSNBC political analyst Joan Walsh corrected attempts to cast doubt on the fact that Hillary Clinton served as defense attorney on a decades-old criminal case at the direction of the court, pointing out that, in fact, the judge had compelled Clinton to take the case.
The July 8 edition of MSNBC's Hardball with Chris Matthews rehashed Hillary Clinton's work as a court-appointed defense attorney in the 1975 prosecution of an alleged rapist, a role that, while known publicly for years, is reemerging in wake of the conservative Washington Free Beacon's improper appropriation and publication of an interview Clinton gave in the mid-1980s discussing the case.
During the discussion, frequent MSNBC guest and president of the conservative Bernard Center for Women Michelle Bernard repeatedly suggested that Clinton had elected to represent the defendant of her own volition. Joan Walsh, Salon editor and MSNBC analyst, attempted to correct the record on Clinton's court appointment, pointing out that "she was court-appointed" and that the judge had forced her to take the case. Bernard, however, continued to imply Clinton may have voluntarily accepted the role after speaking with the prosecutor.
The fact that the court appointed Clinton to represent the defendant is not in doubt. The judge -- not the prosecutor -- directed Clinton to take on the case, as Glenn Thrush established in a 2008 Newsday report:
Joe Scarborough and Ezra Klein are helping to normalize guilt-by-association smears targeting defense attorneys based on their clients, arguing that Hillary Clinton's work defending an alleged child rapist in 1975 is becoming a political liability.
The American Bar Association has condemned this type of attack as "disturbing."
Clinton's work on the case, known publicly and reported on for years, re-emerged after the Washington Free Beacon violated library policy and published an interview Clinton gave in the mid-1980s discussing her legal representation of the alleged rapist.
Clinton defended her work on the case in an interview with Mumsnet that was published July 4, explaining once again that she was assigned to the case, that she asked to be relieved from the assignment, and that she "had a professional duty to represent my client to the best of my ability."
Reporting on the warmed-over scrutiny of the case on Tuesday, Vox claimed that "a criminal defense case from Hillary Clinton's past as a lawyer is becoming a political liability." The headline ominously stated: "Hillary Clinton's legal career is coming back to haunt her."
Klein, the co-founder of Vox, appeared on Morning Joe to expand on the idea that Clinton's legal work was a political liability. "I think it's hard for folks to understand why you would go to the mat for a client who had done something terrible who you knew is guilty," Klein said. "And what she's saying there is that that was her obligation as a lawyer and that the prosecution had done a horrible job."
While Scarborough at one point agreed that attorneys "usually take that court appointment and do their best to defend their client," he subsequently tried to parse the distinction between a public defender and Clinton's role as a court-appointed attorney from a legal aid clinic:
SCARBOROUGH: [I]sn't there a distinction, though, between when you are hired by a public defender's office, and the purpose of the public defender's office is actually to give people the representation that they are guaranteed by the Constitution of the United States of America? And then you have Hillary Clinton's case, where she was running a legal clinic. She may have been court-appointed, but obviously she had a lot more discretion on whether she was going to take a child rapist or not on as a client than if you are a public defender, where you are working as a public defender, you have no choice.
Legal and child welfare experts told Newsday that Clinton's work in the case was appropriate in 2008, the last time her work in the case came under media scrutiny. Clinton wrote about the case in her 2003 autobiography, Living History. Jonathan Adler, a libertarian law professor, has urged Clinton's critics not to attack her representation in this case, specifically warning that it could be chilling to send a message to young attorneys that representing unpopular clients could become a "political liability."
Adler is not alone. Republicans Ken Starr, Lindsey Graham, and Michael Mukasey have all cautioned against using an attorney's clients as a cudgel.
From the July 7 edition of MSNBC's All In with Chris Hayes:
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CNN, Fox News, and evening news shows on NBC, ABC, and CBS largely ignored a June 23 report by the New York Times that New Jersey Governor Chris Christie's (R) administration may be tied to a second bridge investigation involving possible securities law violations.
From the June 18 edition of MSNBC's PoliticsNation:
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CNN and Fox News have largely ignored the news that President Barack Obama plans to sign an executive order prohibiting anti-LGBT employment discrimination by companies that contract with the federal government - an historic measure that will protect up to 28 million workers.
On June 16, a White House official revealed that President Obama would sign an executive order banning federal contractors from discriminating on the basis of sexual orientation or gender identity. The move comes seven months after the U.S. Senate passed the Employment Non-Discrimination Act (ENDA), a measure that has subsequently languished in the House as Speaker John Boehner (R-OH) refused to bring the measure up for a vote.
ENDA's diminishing prospects led many LGBT activists and Democratic lawmakers to press Obama to sign an executive order prohibiting anti-LGBT employment discrimination by federal contractors. The ACLU's Ian Thompson hailed an executive order as "the single most important step" Obama could take absent congressional action to combat anti-LGBT employment discrimination. One estimate suggests that Obama's executive order will protect up to 28 million workers.
In a June 16 segment highlighting the persistent problem of anti-LGBT employment discrimination, MSNBC's Rachel Maddow laid out the context of congressional intransigence that led to Obama's decision to act unilaterally on the issue:
While Maddow's network gave the news of the impending executive order 31 minutes of coverage, CNN and Fox News barely covered it at all, with each providing a mere 20 seconds of coverage:
From the June 17 edition of MSNBC's Morning Joe:
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From the June 16 edition of MSNBC's The Ed Show:
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There's plenty of activities to choose from in the KVOE listening area this weekend.
Wanted: a few good drivers for pickup and delivery of Friendship Meals.
One person died in a two-vehicle accident near Hillsboro Thursday.
Emporia's Granada Theater continues a jam-packed concert season Sunday with Juice Newton and Exile.
Abundant Harvest has seen an abundance of activity in recent weeks.
The Kansas Department of Transportation has asked cities and counties along the U.S. Highway 50 corridor to submit letters of support for expansion projects. It will receive one from Lyon County.
The 12th annual Wildlife Conservation and Appreciation Days begin Friday at Bluestem Farm and Ranch Supply.
In late June, a partnership was announced between Newman Regional Health and Mathis Physical Therapy. That partnership is now operational.


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Selena Helene
Meghana Helene
Priya Helene
Please and thank yous!
Don't like Meghana at all... Selena is nice, but Selena Helene just sounds ridiculous and rhymey to me. And I think Priya is a bit too matchy with Maya...
I vote for Selena. I think it sounds silly with Helene, but since it's a middle name and wont be used very often, it doesn't bother me as much as the matchiness of Maya and Priya does.
me + him = him
acronyms and such ( o Y o )
i like the name selena buy try a different middle name or use the the middle name as her first then fine another name
Jenn (27) & Jon (28) - Married 8/11/12
#1 Due 8/18/13!
Wife to 1 Hero; Momma to 3 Princesses. :)
I automatically read Pri-ya, same ending as in Maya. Do you want Pri-a? Then maybe it should be Pria. Although I'm not familiar with the correct spelling of this name.
It's my favorite though.
Missing my mom <3
Finally good news! #3 is on it's way!!
Mom to four daughters
Ticky 11/01 Sis 11/02
Kay 3/06 Ru 6/12


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Last weekend Josh and I met Aja and Oli for their engagement session at Narragansett Beach. We had a break in the recent freezing temps and enjoyed a sunny winter day at the beach. This location was special to the two of them because it's where Oli proposed to Aja, and where Aja considers home […]Pin It
Tag Archives: Candace Jeffery Photography
What a fun wedding Megan and Ben had! It was New Years Eve, and they through an amazing party for their friends and family. Everything conveniently took place a the Hartford Marriott, the ceremony, portraits as well as the reception. Our favorite thing about this wedding? The crisp, clean, traditional black and white theme carried throughout […]Pin It
Shooting Lauren and Rich's wedding was like celebrating with family. Their wedding was so lovely, romantic and fun, and it was great to see so many familiar faces throughout the day. Both Lauren and Rich have a strong bond with their families, and it was refreshing to see that displayed in many ways. After a […]Pin It
Monique and Rich's wedding took place on a beautiful, but very cold, November day. Their ceremony was held at the Kingdom Hall in Colchester CT. We (Maegan and Joe) were so excited when their families and Bridal Party braved the chilly air for some beautiful portraits at Priam Vineyards right before sunset! We then made […]Pin It
Renee and Nii have been together for many years, so their wedding was a long awaited celebration of love with friends and family traveling from all over the world. After getting ready at the Hilton in Hartford, with the sun rising in the sky, we traveled by trolly to the Old State House for their ceremony. All […]Pin It


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Diy Patched Jeans
Transform your old ripped jeans into cute and fashionable patched jeans.
You can really mix up your patches and put some vertical and some horizontal to give it a more haphazard look. You want these to look like you patched them yourself.
This is a really great way to improve your old ripped boyfriend jeans. These DIY Patched Jeans can really be dressed up or down. I recommend wearing them with cute heels, a simple top and lots of big jewelry. If you're going to borrow a style from the boys make sure to add your own feminine touch. A cute heel and a little sparkle will go a long way to keep you from looking like you've been cleaning house all day.
- pandanomz added Diy Patched Jeans to my list 08 Sep 14:51
- Mary J. favorited Diy Patched Jeans 23 Mar 20:12
- stephanie.goodsell.54 added Diy Patched Jeans to Clothing 04 Feb 17:30
- Sam J. added Diy Patched Jeans to Clothes 24 Nov 05:32
- Queen of the Sidhe favorited Diy Patched Jeans 02 Nov 21:54
- Maureen M. favorited Diy Patched Jeans 23 Jun 04:33
- Nora E. added Diy Patched Jeans to Projects to try 28 May 17:31
- Lacey C. commented on Diy Patched Jeans 24 May 22:18
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Step 1
What you'll need to make your DIY Patched Jeans:
1 Pair of ripped jeans.
Extra denim from another pair of jeans
Grosgrain fabric in a stripe or other fabric you want to add
Needle and contrast color thread
Step 2
Step 1
Lay your jeans out flat and measure your extra denim and fabric to make your patches. You will need patches for the inside of your jeans where the holes are and more decorative patches for the outside.
Step 3
Step 2
Pin your patches on the inside of your jeans and using your needle and thread sew them on.
I used a black thread and made my stitches large and visible to really give it a hand patched look.
Step 3
Lay your jeans flat and place all your patches on your jeans, overlapping them and mixing up the denim and other fabrics.
Once you have all your patches where you want them, pin them to your jeans.
I folded all the edges over before pinning mine, you can leave raw edges if you prefer, it just depends on how you want your jeans to look.
Step 4
Step 4
Again using your needle and thread sew your patches to your jeans.
I used large whip stitches, all around each patch, for this part to give it a more handmade look.
I have been following your blog for a while (I think I found it on Pinterest) and I pretty much love everything you do! You are so talented. You and others bloggers have really inspired me to think outside the box when it comes to fashion.


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FRASER ISLAND: Chinese New Year might be four months away, but a group of entrepreneurial Queensland Tourism Operators are determined to get the jump on potential Chinese group tourism business for 2015 by joining forces with one of China's biggest travel retail agents on a sales mission with a difference.
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Why oh why did it take so long to visit? All the hype justified @kingfisherbay @FraserIsland @frasertours @Qweekend
FISHING WITH LINDSAY THE FRASER ISLAND WORMER: A moderate SE has tailor chewing at the moment. Resort guests caught some nice greenbacks this week - with some fish up to
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February has offered up a moveable feast for Fraser Island's animals along with some spectacular weather and fantastic wildlife spotting in and around the resort grounds. The island's native Midyim
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Trip Advisor has just named our very own 75-Mile Beach in the Top 25 beaches in Oz in their Traveller's Choice awards. #fraserisland
FRASER ISLAND: Who would've guessed that a short 50-minute ferry ride from a tiny beachside suburb in Hervey Bay could transport you into an official stress-free holiday zone, complete with sweeping golden beaches, aquatic adventures and an unspoiled island wilderness just offshore. Kingfisher Bay Resort, on the western side of World Heritage-listed Fraser Island, has released two special deals for Easter and beyond. Read More
FRASER ISLAND: Short jumps, sand traps and soft hill climbs are all just part of a hard day's work when it comes to Australian Offroad Academy's new eco-accredited, practical sand driving course at Kingfisher Bay Resort.
Butchulla granted native title rights on #fraserisland frasercoastchronicle.com.au/news/federal-c… Photo Jocelyn Watts
The golden hour by our mirror lakes... This private pocket is just a stone's throw from our Boomanjin hotel wing #fraserisland #kingfisherbay. Pic BY @glmathew
RT @MarieBarbieri: On a Cool Dingo Tour, revellers toast Fraser Island at Champagne Pool. @kingfisherbay
Channel Nine Blockheads Michael and Carlene have a special #fraserisland connection:
You never know quite what you'll spot on a #fraserisland day tour. Here, bait fish swarm in the shape of the Schwarzkopf shampoo logo off Indian Head. #thisisqueensland
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The vote's are in... if you're planning a family holiday, you'll want to see this ow.ly/Ct29E #fraserisland
FRASER COAST: Fraser Island is arguably the world's biggest natural theme park and its pristine wilderness understandably draws a lot of year-round attention from the
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Springtime is beautiful on Fraser Island as our wildflowers, including the rarely seen and aptly named Fraser Island Creeper (Tecomanthe hilli) – with its clusters of pink tubular flowers bloom on island.
A once-in-a-lifetime experience. Soccer legend, Harry Kewell, swaps the footie for a rashie and plunges in to the Great Sandy Strait to swim with our holidaying humpbacks! Photo: Andrew Tallon Humpback Whale Watching in the calm waters on the lee side of Fraser Island #whalesherveybay #fraserisland #queensland #australia #humpbackwhales #whalewatching http://www.whalewatch.com.au/ www.queensland.com/whales
RT @bmagbrisbane: Feeling a little stressed about the #G20? We've found the perfect escape...
As Brisbane grinds to a halt this November, consider swapping World leaders for World Heritage with a long weekend on #fraser!
Spida Everitt and the team from Great Australian Doorstep explore our World Heritage-listed backyard. #fraserisland:
Our backyard has just been voted in the top 25 Beaches In Oz by Trip Advisor. #fraserisland
Our backyard has just been voted in the top 25 Beaches In Oz by Trip Advisor. #fraserisland ow.ly/i/78dng
SEPT: It is shaping up to be a beautiful month here on Fraser Island and we are seeing some wonderful flowers and animals flourishing in the early stages of spring. September is alsoBiodiversity Month in Australia and, for us, it is all about protecting the environment and conserving the species within our Great Sandy Biosphere
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Another dreamy thing to cross off my 'bucket list'! A beautiful dingo on the beach of Fraser Island!! I couldn't believe my eyes! He just walked straight towards us after a play in the ocean!! He was so cool!!! Then he just sat down only a metre or so from us!!! aaarrrghhhh I'm so happy right now!!! Actually we're in Happy Valley right now and about to head out to find a spot for sunset!! Eeeekkkk!! And only one more sleep till the BIG @queensland instameet!! So exciting!! #thisisqueensland @visitfrasercoast #visitfrasercoast
I watched her run between the jetty posts, dance in the shadows, write her name in the sand, make a little person that she called 'Paddle-sea' out of a gumnut & sticks, splash in the shallows and explore with her Dadda! #toysareoverrated #mckenziejetty #fraserisland #thisisqueensland #queensland #subjectlight
A look back over an awesome year on #fraserisland. We HEART our island backyard. #kingfisherbay #thisisqueensland #seeaustralia
If you love fishing, catch AFC on YouTube or Ch9 this Sunday at 11.30 (check your local guides) ow.ly/CLQdP #fraserisland
Rebecca Wilson of Gympie has secured a dream job on Fraser Island after completing a Bachelor of Environmental Science at the University of the Sunshi...
Now I know what you're all thinking!! Yes it's another whale shot! But omg! Not just any whale! This little cutie was only two or three days old, and was already breaching like a champion today!! So teency tiny at mere 4 metes long! Haha!! It was rough as heck out there and I was a little giddy, but it was totally worth it to see a brand new baby humpback! I cried!! And to see this.... Well! Only in Hervey Bay!! @queensland #thisisqueensland
Visit us during IMM at Booth 52 or at ATE at Booth 275, Hall C (in the Queensland section) for the latest developments from Fraser Island. Kingfisher Bay Resort (KBR - incorporating the 152-room Mercure Kingfisher Bay Resort hotel), Eurong Beach Resort (EBR), Fraser Explorer Tour (FET) and Cool Dingo Tour (CDT) programs are designed to provide enjoyable nature-based tourism experiences on Queensland's Fraser Island.
Sagely advice from the lovely Alexx Stuart after a recent trip to #fraserisland #kingfisherbay
Sagely advice from the lovely Alexx Stuart after a recent trip to #fraserisland #kingfisherbay ow.ly/i/74SoA ow.ly/Cb2Ra


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Carnival Games series, heading exclusively to the Xbox 360 with Kinect functionality in-tow. Dubbed Carnival Games: Monkey See, Monkey Do, the family-friendly followup to the previously Nintendo-only franchise will launch at retail "this April."
2K Play's Cat Daddy Games is handling development of the title, which plans on bringing back characters like The Amazing Wodin and introducing (we're not joking here) Monkey Barker. Apparently Mr. Barker is "smartly dressed and renowned for his dancing skills" -- sure, why not?
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I recall when I was in the military we were always hearing about the probes the Russians were sending into our airspace….I guess testing our response time in case it was needed in the event of a war with the US and her allies……but after the fall of the Soviet Union and the end of the Cold War such "war games" were not needed any longer….but guess what, sports fans?
While you were worried about the NFL and its stellar reputation things were changing……..
Russian military pilots seem to be getting a little adventurous these days. A pair of US military jets intercepted six Russian aircraft near the coast of Alaska Wednesday evening, reports AP. The Russian pilots never entered US airspace, but instead remained in something called the Air Defense Identification Zone, which extends about 200 miles from the coast. Still, NORAD sent up two US jets "basically to let those aircraft know that we see them, and in case of a threat, to let them know we are there to protect our sovereign airspace," says a spokesperson. The six Russian planes—two fighter jets, two long-range bombers, and two refueling tankers—eventually looped back toward Russia.
Hours later, Canadian fighter jets intercepted two Russian long-range bombers over the Beaufort Sea, near the Canadian coast but again in the international zone. While such incidents aren't all that uncommon, one US official tells CNN that Moscow was likely expressing its displeasure about a visit by Ukraine President Petro Poroshenko to the US and Canada. Elsewhere, two Russian military aircraft entered Swedish air space without authorization, reports the BBC. Sweden's foreign ministry called it a "serious violation" and has summoned the Russian ambassador to complain.
Yep, that is right Gertrude….the probes have returned. Russia is once again probing our airspace and our response time……why would they be doing that?…(he asked smilingly).