text:
The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity.
ABSTRACT Protection of the patients against the side effects of chemotherapy and radiotherapy regimens has attracted increasing interest of clinicians and practitioners. Caffeic acid phenethyl ester (CAPE), which is extracted from the propolis of honeybee hives as an active component, specifically inhibits nuclear factor κB at micromolar concentrations and show ability to stop 5-lipoxygenase-catalysed oxygenation of linoleic acid and arachidonic acid. CAPE has antiinflammatory, antiproliferative, antioxidant, cytostatic, antiviral, antibacterial, antifungal and antineoplastic properties. The purpose of this review is to summarize in vivo and in vitro usage of CAPE to prevent the chemotherapy-induced and radiotherapy-induced damages and side effects in experimental animals and to develop a new approach for the potential usage of CAPE in clinical trial as a protective agent during chemotherapy and radiotherapy regimens.
- SourceAvailable from: PubMed Central
Article: Protective antioxidative effects of caffeic acid phenethyl ester (CAPE) in the thyroid and the liver are similar to those caused by melatonin.[Show abstract] [Hide abstract]
ABSTRACT: Whereas oxidative reactions occur in all tissues and organs, the thyroid constitutes such an organ, in which oxidative processes are indispensable for physiological functions. In turn, numerous metabolic reactions occurring in the liver create favourable conditions for huge oxidative stress. Melatonin is a well-known antioxidant with protective effects against oxidative damage perfectly documented in many tissues, the thyroid and the liver included. Caffeic acid phenethyl ester (CAPE), a component of honeybee propolis, has been suggested to be also an effective antioxidant. The aim of the study was to evaluate the effects of CAPE on Fenton reaction-induced oxidative damage to membrane lipids (lipid peroxidation, LPO) in porcine thyroid and liver, and to compare the results with protective effects of melatonin.Thyroid Research 01/2014; 7:5.
Article: Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review.[Show abstract] [Hide abstract]
ABSTRACT: Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.TheScientificWorldJournal. 01/2014; 2014:561971.
- [Show abstract] [Hide abstract]
ABSTRACT: Abstract As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.08/2014;
Page 1
The potential usage of caffeic acid phenethyl ester (CAPE) against
chemotherapy-induced and radiotherapy-induced toxicity
Sumeyya Akyol1, Zeynep Ginis2, Ferah Armutcu1, Gulfer Ozturk2, M. Ramazan Yigitoglu1and Omer Akyol3,4*
1Department of Biochemistry, Fatih University Medical School, Ankara, Turkey
2Department of Clinical Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
3Department of Biochemistry, Hacettepe University Medical School, Ankara, Turkey
4Department of Chemistry, Ankara Branch of Council of Forensic Medicine, Ankara, Turkey
Protection of the patients against the side effects of chemotherapy and radiotherapy regimens has attracted increasing interest of clinicians and
practitioners. Caffeic acid phenethyl ester (CAPE), which is extracted from the propolis of honeybee hives as an active component,
specifically inhibits nuclear factor kB at micromolar concentrations and show ability to stop 5-lipoxygenase-catalysed oxygenation of linoleic
acid and arachidonic acid. CAPE has antiinflammatory, antiproliferative, antioxidant, cytostatic, antiviral, antibacterial, antifungal and
antineoplastic properties. The purpose of this review is to summarize in vivo and in vitro usage of CAPE to prevent the chemotherapy-induced
and radiotherapy-induced damages and side effects in experimental animals and to develop a new approach for the potential usage of CAPE in
clinical trial as a protective agent during chemotherapy and radiotherapy regimens. Copyright © 2012 John Wiley & Sons, Ltd.
key words—caffeic acid phenethyl ester (CAPE); antineoplastic; side effect; cancer; treatment
The most common adverse effects of chemotherapeutic
agents such as cisplatin, bleomycine, doxorubucine and the
others have extensively been attributed to the reactive
oxygen species (ROS), although the mechanism underlying
this toxic effects remain unclear. For example, administration
of cisplatin causes an increase in lipid peroxidation products
and a decrease in the activity of enzymes protecting lipid
peroxidation in the kidney. The elimination of these
chemotherapeutic-induced toxicity is an ongoing concern.
Caffeic acid phenethyl ester (CAPE) has antiinflammatory,
immunomodulatory, antiproliferative and antioxidant proper-
ties and has been shown to inhibit lipoxygenase activities as
well as suppress lipid peroxidation.1It is an antiinflammatory
component of propolis and reportedly a specific inhibitor of
nuclear factor kB (NF-kB). The aim of this review article is
to investigate the potential protective role of CAPE on che-
motherapeutic-induced andirradiation-inducedtoxicityincel-
lular systems and animal models.
CAPE (Figure 1), a polyphenolic component of propolis,
has been studied worldwide. It is an active component of
propolis and has antitumoural, antiinflammatory, antineo-
plastic and antioxidant properties. It is a white powder used
as a commercial product with a storage temperature of
?20?C and soluble in ethanol, dimethyl sulfoxide (DMSO)
and ethyl acetate (50mgml?1). Its empirical formula is
C17H16O4and has 284.31gmol?1molecular weight.
The pharmacokinetics of CAPE and its catechol-ring
fluorinated derivative following intravenous administra-
tion to the rats were studied and found that the body
clearance values were ranged from 42.1 to 172mlmin?1
kg?1decreasing with the increasing dose of CAPE. The
volume distribution values were ranged from 1555 to
5209mlkg?1decreasing with dose, and the elimination
half-life was ranged from 21.2 to 26.7min showing
independence from the dose; taken together, CAPE was
distributed extensively into the tissues and eliminated
rapidly, indicating a high value of volume of distribution
and similar short elimination half-life.2The in vitro
stability of CAPE in rats and human plasma was previ-
ously investigated, and CAPE was found to be hydro-
lysed to caffeic acid after 6h within rat plasma in vitro
and is also hydrolysed to caffeic acid as the major
metabolite in vivo.3CAPE is a potent inhibitor of
NF-kB. Furthermore, it significantly suppresses the
lipoxygenase pathway of arachidonic acid metabolism
during inflammation in micromolar concentrations. It
completely blocks production of ROS in human neutro-
phils and the xanthine/xanthine oxidase (XO) system at
10mM concentration.
*Correpondence to: Dr Omer Akyol, Department of Biochemistry,
Hacettepe University Medical Faculty, Sihhiye, Ankara, Turkey. E-mail:
Received 26 December 2011
Revised 26 January 2012
Accepted 6 February 2012
Copyright © 2012 John Wiley & Sons, Ltd.
cell biochemistry and function
Cell Biochem Funct 2012; 30: 438–443.
Published online 20 March 2012 in Wiley Online Library
(wileyonlinelibrary.com) DOI: 10.1002/cbf.2817
Page 2
The composition of propolis depends on the type of
vegetation and the area of the collection.4Regardless of
the source of propolis, CAPE is one of the most investigated
and precious component of propolis. CAPE can be either
extracted from propolis by using available extraction
methods or synthesized by several methods such as response
surface methodology from caffeic acid and phenethyl
alcohols with a molar conversion value of 96%5and
91.2%.6Its analogs such as 2-cyclohexylethyl caffeate
from transesterification of methyl caffeate with Candida
antarctica lipase B by using an ionic liquid, 1-butyl-3-
methylimidazolium bis(trifluoromethylsulfonyl)imide, as a
solvent. These all have antiproliferative effects comparable
with that of 5-fluorouracil by MTT assay.7
Doxorubicin toxicity
Antineoplastic chemotherapy demolishes the physiological
homeostasis of several organs. Effective anticancer therapy
with anthracyclines is limited because of toxicity especially
in kidneys. The toxicity is originated from radical formation
and oxidant injury. Doxorubicin has been used for haemato-
logical malignancies, and its side effects such as acute renal
failure are limiting factors of its usage for that purpose. The
nephrotoxic action of doxorubicin is thought to be a part of
free radical generation. Our colleagues conducted a study to
induce renal injury by injecting 20mgkg?1single injection
of doxorubicin to the Sprague–Dawley rats.8The rats were
pretreated with CAPE, which was shown to protect renal
tissues against doxorubicin-induced nephrotoxicity. Thus,
they offer CAPE to be an effective course of therapy to
enhance therapeutic efficacy and to lessen doxorubicin
toxicity in clinical chemotherapy. Anthracyclines may also
induce cardiotoxicity during chemotherapy. The same
pathophysiology like nephrotoxicity is suggested for
cardiotoxicity, i.e. the ROS formation-based cardiomyocyte
injury. Not for CAPE but for caffeic acid, authors showed
the effective cytoprotective activity against doxorubicin-
induced cardiotoxicity in rats.9Fadillioglu et al. designed
a study to see the protective effect of CAPE against doxo-
rubicin-induced cardiotoxicity in rats and the changes in
oxidant–antioxidant status of heart tissue.10According to
the tests they conducted, haemodynamic changes, biochem-
ical parameters, and electron microscopy revealed signifi-
cant protection properties of CAPE against cardiotoxicity
and suggested it an appropriate compound for clinical trials
because of its lipophylic character and inhibitory effects on
lipid and protein oxidations. The protective effects of CAPE
on doxorubicin-induced neuronal oxidant injury in rats were
also studied by the same researchers, and they suggested
that it can be preadministered safely to prevent brain injury
through its antioxidant properties.11In a cell culture study,
when the human medulloblastoma cells were given
0.01mM doxorubicin, cell growth was obviously inhibited,
reducing cell viability from the untreated 100% to 41.5%.
When the cells were given 0.1mM CAPE and 0.01mM
doxorubicin simultaneously, cell viability was reduced from
the untreated 100% to 69.8%. Therefore, the addition of
CAPE simultaneously to the treatment regimen of doxorubi-
cin did not show chemosensitizing effect.12
Cisplatin toxicity
Cisplatin (cis-diamminedichloroplatinum II) is a widely
used antineoplastic agent in the treatment of solid tumours
including lung cancer. The most common side effect
limiting the use of cisplatin for solid tumours is nephrotox-
icity, which develops toxic effects primarily in proximal
tubules. The proposed mechanism for this toxicity is simply
the generation of ROS. The treatment of rats with CAPE
prior to cisplatin administration was found to have pre-
vented cisplatin-induced nephrotoxicity as measured by
BUN, creatinine, NO, catalase (CAT), superoxide dismutase
(SOD), glutathione peroxidase (GSH-Px), myeloperoxidase
andhistological examination
analyses.13The protective effect of CAPE on cisplatin-
induced chromosome aberrations has been studied in rat bone
marrow cells. CAPE has led to a statistically significant
decrease in the total number of chromosomal aberrations and
abnormal metaphases induced by cisplatin when compared
with only cisplatin-administered groups14by the mechanism
of free radical scavenging effect. High doses of cisplatin
may also induce hepatotoxicity. Our team previously con-
ducted a study to illuminate whether CAPE is effective on
hepatotoxicity induced by cisplatin in 24 adult female Wistar
albino rats. Oxidative/antioxidative parameters were studied
and noticed that CAPE may prevent cisplatin-induced oxida-
tive changes in liver by strengthening the antioxidant
defence system andbyreducing ROS.15Similarfindingswere
also obtained from another study in which CAPE attenuated
model of cisplatin-induced nephrotoxicity.16
Another experimental study was designed to determine
the effect of CAPE on ototoxicity induced by cisplatin.17
Xanthine oxidase has been known as an oxidant enzyme
especially in ischemic conditions. Xanthine dehydrogenase
and XO catalyse the same reaction at the end steps of purine
catabolic pathway and involved in depletion of adenylate
pool. Xanthine dehydrogenase enzyme may be converted
to XO to produce more superoxide radicals in several condi-
tions including ischemia/reperfusion and oxidizing environ-
ment induced by some agents such as cisplatin. Cisplatin
may trigger the ototoxicity process via this pathway. Plasma
Figure 1.The chemical structure of caffeic acid phenethyl ester (CAPE)
439caffeic acid phenethyl ester
Copyright © 2012 John Wiley & Sons, Ltd.
Cell Biochem Funct 2012; 30: 438–443.
Page 3
XO activity was found to be more elevated in the cisplatin
group than the control and CAPE groups. CAPE led to
decrease XO activity compared with the cisplatin group.
The authors claimed that prophylactic administration of
CAPE for cisplatin ototoxicity ameliorated hearing deterior-
ation of rats. When the medulloblastoma cells were given
0.3mM cisplatin, cell growth was obviously inhibited,
reducing cell viability from the untreated 100% to 27.6%.
When the cells were given 0.1mM CAPE and 0.3mM
cisplatin simultaneously, cell viability was reduced from the
untreated 100% to 24.9%, so the addition of CAPE to the
treatment of cisplatin did not show chemosensitizing effect.12
Methotrexate and arabinoside cytosine toxicity
Methotrexate (MTX), a folic acid antagonist, is a widely
used antineoplastic agent for various neoplastic conditions
such as lymphoma, acute lymphoblastic leukaemia, solid
cancers and some autoimmune diseases such as rheumatoid
arthritis. As per a hypothesis, mucosal barrier injury is acti-
vated by NF-kB, and this injury limits the effectiveness of
anticancer therapy in gastrointestinal tract. The effect of
NF-kB inhibition was studied to stop dose-limiting side
effect of the intestinal injury in cancer treatment.18After
administration of cytotoxic drugs such as arabinoside cyto-
sine and MTX, NF-kB was activated. It induced TNF-a
and monocyte chemoattractant protein-1 in intestinal epithe-
lial cells. NF-kB inhibition by CAPE increased the suscep-
tibility of intestinal epithelial cells to arabinoside cytosine
as well as MTX-induced cell death.18So, the combination
of CAPE with anticancer treatment with MTX would be a
useful tool for cancer treatment protocol. The possible role
of adenosine deaminase (ADA) activity and NO levels in
the pathogenesis of MTX-induced spinal cord toxicity and
whether there is a preventive effect of CAPE on undesired
neurotoxic effect of MTX were investigated by our collea-
gues.19They found that a single dose of 20mgkg?1body
weight MTX caused a significant increase in ADA activity
and NO level in spinal cord tissues, and CAPE had a pro-
tective effect by reversing biochemical and histopatho-
logical parameters to the control levels. MTX-induced
renal tissue oxidative stress in rats was also studied. MTX
administration to the control rats increased MDA levels
but decreased SOD, CAT and GSH-Px activities, whereas
CAPE caused a decrease in MDA levels and an increase in
the above-mentioned antioxidant enzyme activities.20
The role of CAPE on cerebellar oxidative stress induced
by MTX in rats was studied and found that CAPE is a poten-
tially available agent to protect cerebellum from oxidative
damage caused by MTX in respect of antioxidant enzymes
and lipid peroxidation.21The other organ that is under the
risk for MTX toxicity is testes. Nineteen male rats were sub-
jected to single dose of MTX, and some of the oxidant/
antioxidant parameters were studied to see the protective
effect of CAPE. The administration of MTX caused the ele-
vation of oxidative stress leading to the destruction of the
tissue, although treatment with CAPE has a protective effect
on the oxidative stress in testes.22Increasing numbers of
studies regarding nephrotoxicity of MTX and the protective
role of CAPE on it has been conducted. They found that
NO, XO and ADA may play an important role in the patho-
genesis of MTX-induced oxidative renal damage, and
CAPE may have a protective potential in this process lead-
ing its acceptance as a promising drug in the prevention of
undesired side effect of MTX.23In a newly released study,
investigators examined the protective role of MTX-induced
hepatorenal oxidative injury in rats.24They injected MTX
(20mgkg?1) and CAPE (10mmolkg?1within DMSO)
intraperitoneally to the corresponding groups, obtained
blood samples and hepatic and renal tissues, and analysed
for TNF-a, IL-1b, MDA and GSH levels as well as MPO
and Na+K+-ATPase activities. They also microscopically
evaluated hepatic and renal tissues. CAPE significantly
reduced TNF-a and IL-1b levels in serum compared with
MTX group in which TNF-a and IL-1b levels were four
times higher than the control serum. MTX administration
elevated MPO (indicative of neutrophil infiltration into the
tissues) activity and MDA levels whereas CAPE lowered
these parameters in renal and hepatic tissues. On the other
hand, the GSH levels and Na+K+-ATPase activities were
decreased in hepatic and renal tissues whereas both para-
meters were restored upon administration of CAPE, show-
ing the protective effect of CAPE on membranes and other
subcellular colloidal compartments. It was concluded that
CAPE may have a therapeutic potential in MTX-induced
renal and hepatic damages.24
Bleomycin toxicity
As a mixture of glycopeptides derived from Streptomyces
verticillus, bleomycin is a chemotherapeutic agent and is
known to induce pulmonary fibrosis in human as well as
in experimental animals. Also, bleomycin-induced pulmon-
ary fibrosis is a popular animal model of lung fibrosis and
results from an inflammatory reaction of the lungs mediated,
in part, by neutrophils and macrophages. To prevent this,
fibrosis limited studies have been conducted up to now.
CAPE is an available agent to prevent bleomycin-induced
fibrosis via antioxidant and free radical scavenger proper-
ties. Bleomycin hydrochloride was applied into the animal
lung via the tracheal cannula in control group, and CAPE
was injected into the peritoneum at a dose of 10mgkg?1
body weight 2days prior to the procedure and continued
for 14days.25It was obvious that CAPE has an inhibitory
effect on neutrophil sequestration into the tissue protecting
the tissues from ROS produced in huge amount in relevant
tissues by neutrophils. This study showed that intraperito-
neal administration of CAPE inhibited bleomycin-induced
lung fibrosis effectively.
Tamoxifen toxicity
Tamoxifen is an anticancer agent that has been used for the
treatment and prevention of breast cancer. Its main toxicity
is directed to the liver. After giving 45mgkg?1day?1of
tamoxifen for 10 consecutive days to the female rats,
researchers investigated the protective role of CAPE for
440s. akyol ET AL.
Copyright © 2012 John Wiley & Sons, Ltd.
Cell Biochem Funct 2012; 30: 438–443.
Page 4
hepatotoxicity by determining liver enzymes, GSH, oxi-
dized GSH (GSSG), antioxidant enzymes and lipid peroxi-
dation parameters.26They found that tamoxifen application
resulted in the elevation of serum liver enzymes, depletion
of liver GSH, accumulation of GSSG and lipid peroxidation.
They also found that tamoxifen treatment resulted in the
inhibition of hepatic antioxidant enzymes such as SOD,
CAT and glutathione reductase (GSH-R), elevation of liver
TNF-a level, and induction of histopathological changes.
Pretreatment with CAPE at the dose of 2.84mgkg?1day?1,
ip, for 20 consecutive days, significantly prevented liver tox-
icity in the mean of all of the above-mentioned parameters.
NF-kB is known to play an important role in the inducible
expression of many genes, including cytokines in gout
immune and inflammatory responses. The mechanism
beyond the induction remains unknown. Irradiation induces
an inflammatory syndrome in the intestines that involves
activation of the transcription factor NF-kB. Because CAPE
is a potent inhibitor of NF-kB, researchers applied CAPE to
the rats to figure out the early postirradiation inflammatory
molecular events within the muscularis layer of ileum.27
The inhibition of NF-kB by CAPE did not prevent the
increase in primary proinflammatory cytokines TNFa and
IL1b. The expression of mRNA for IL8, IL6 and IL6 recep-
tors and of the SOCS3 genes was markedly lower. They
suggested that CAPE could prevent the development of
inflammation after irradiation.
The treatment of tumours with chemotherapeutic drugs
and radiation has many problems such as time-dependent
development of tumour resistance to therapy and nonspeci-
fic toxicity toward normal cells. CAPE is being used for
radiation-induced lung injury in rats. In a study, CAPE
was injected 24h before and every day after radiation to test
the protective effect of CAPE.28They found that CAPE
application with radiation therapy attenuated radiation-
induced pulmonary injury in vivo, by most probably its anti-
oxidant effect. CAPE has also been used for enhancing
radiosensitizing of medulloblastoma cells even if its mech-
anism is yet unclear. Lee et al. treated medulloblastoma cells
with CAPE in different concentrations and assessed for cell
viability and found that CAPE inhibited the growth in
medulloblastoma cells. On the other hand, CAPE treatment
led to a decrease in GSH-R activity and an increase in SOD
activity and enhanced the radiation-induced apoptosis in
medulloblastoma cells.29A study aimed to pharmacologic-
ally modulate Th polarization in the ileum exposed to ioniz-
ing radiation by using the immunomodulatory/apoptotic
properties of CAPE showed that CAPE amplified apoptotic
events at 6h and normalized Bax/FasL expressions at
7days. They concluded that CAPE prevented the ileal Th2
immune response by modulating the irradiation-influenced
cytokine environment and apoptosis.30Chen et al. showed,
in an in vitro study on normal lung fibroblast and lung
cancer cell line, that CAPE treatment decreased the expres-
sion of inflammatory cytokines including IL-1a and b,
IL-6, TNF-a and TGF-b after irradiation, leading to the idea
that it could decrease the cascade of inflammatory responses
induced by thoracic irradiation without causing toxicity in
normal lung tissue.31
Radiosensitization of colorectal adenocarcinomas is
regarded to be one of the most important issues for the suc-
cess of the radiotherapy. Pretreatment of nontoxic doses of
CAPE enhanced cell killing by ionizing radiation with
sensitizer enhancement ratios up to 2.2 in addition to
increased SOD, decreased GSH-R activities as well as sensi-
tizing CT26 colon carcinoma cells (colorectal adeno-
carcinomas) to ionizing radiation.32Chen et al. allegedly
supported the radiosensitization, cytotoxicity and apoptosis
effects of CAPE to be associated with GSH depletion that
occurred shortly after treatments to lung cancer cells
(A549) and normal lung fibroblast cells (WI-38) as control
group of the experiment.33What explain this effect is the
demonstrated decreased intracellular thiol levels. To main-
tain high concentration of intracellular thiols is an important
way to resist cytotoxic and radiation damage in cancer cells.
In addition, GSH needs complex processes involving the
activation of stress kinases, redox-sensitive transcription
factors such as NF-kB, AP-1 and enzymes involved in
GSH synthesis.34Because CAPE is a potent inhibitor of
NF-kB and an inductor of the activities of glutathione S
transferase, by using these processes, it depletes GSH levels
causing subsequent radiosensitization of tumour cells.
Cancer is a major health problem despite extreme progresses
in the understanding of the basis of cancer and advances in
the treatment modalities. Besides protective roles of CAPE
against chemotherapy-induced and radiotherapy-induced
toxicity as mentioned above, it has also been used in several
types of tumour models and cancer cells. Central nervous
system cancers, lung cancers, gastrointestinal system can-
cers, breast cancer, prostate cancer, leukaemia and melano-
mas are being studied extensively in in vivo and in vitro
systems. Structurally, CAPE has a high hydrophobicity
and strong inhibitory effect for XO. It binds to the molyb-
dopterin region of its active site and inhibits the activity.35
As mentioned above, XO catalyses the reaction at the end
steps in the purine catabolic pathway, so it can prevent the
nucleotide salvage pathway showing anticancer effect.36
As a biomimic dimerization product of CAPE, benzox-
anthene lignan shows a significant and dose-related inhibi-
tory effect on new vessel growth; on the other hand, it also
inhibits vascular endothelial growth factor secretion in ovar-
ian cells.37Tumour invasion and metastasis pathways are
another target of CAPE in experimental cancer models. A
dose-dependent decrease in matrix metalloproteinases, one
of the important system in tumour metastasis, and inhibitor
of MMP-2 mRNA levels were found in CAPE-administered
441caffeic acid phenethyl ester
Copyright © 2012 John Wiley & Sons, Ltd.
Cell Biochem Funct 2012; 30: 438–443.
Page 5
HT1080 human fibrosarcoma cells.38To test the protective
effect of CAPE by its antioxidative activity in carcinogen-
esis, the lipid peroxidation, DNA oxidation and protein
damage were tested by relevant techniques and found that
CAPE and its esters showed remarkable inhibitory proper-
ties on DNA strand breakage, protein fragmentation and
membrane lipid peroxidation.39Induction of apoptosis has
been suggested as one of the main activities of CAPE in can-
cer. CAPE was shown to suppress 12-O-tetradecanylphorbol-
13-acetate-induced cell transformation and induce apoptosis
in mouse skin epidermal JB6C141 cells (a model for studying
the mechanism of late-stage promoter-dependent preneoplas-
tic progression).40,41Although there have been studies on
the effects of CAPE on several cancer cell lines and animal
models, countless possibilities for investigation still remain.
As seen above, CAPE might be used to sensitize cancerous
cells to chemotherapeutic drugs and radiation procedures by
inhibiting pathways that lead to treatment resistance; more-
over, CAPE has been found to be a protective agent from
therapy-associated toxicities.42In vivo and in vitro usage
of CAPE may prevent the chemotherapy-induced damages
and side effects in experimental animals, and it might lead
the researchers to develop and to implement a new approach
for the potential usage of CAPE in clinical trials as a protect-
ive agent during chemotherapy regimen.
The authors have declared that there is no conflict of interest.
1. Sud'ina GF, Mirzoeva OK, Pushkareva MA, et al. Caffeic acid
phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.
FEBS Lett 1993; 329: 21–24.
2. Wang X, Pang J, Maffucci JA, et al. Pharmacokinetics of caffeic acid
phenethyl ester and its catechol-ring fluorinated derivative following
intravenous administration to rats. Biopharm Drug Dispos 2009;
30: 221–228.
3. Celli N, Dragani LK, Murzilli S, et al. In vitro and in vivo stability of
caffeic acid phenethyl ester, a bioactive compound of propolis. J Agric
Food Chem 2007; 55: 3398–3407.
4. Kumazawa S, Ahn MR, Fujimoto T, et al. Radical-scavenging activity
and phenolic constituents of propolis from different regions of
Argentina. Nat Prod Res 2010; 24: 804–812.
5. Chen HC, Chen JH, Chang C, et al. Optimization of ultrasound-
accelerated synthesis of enzymatic caffeic acid phenethyl ester by
response surface methodology. Ultrason Sonochem 2011; 18: 455–459.
6. Chen HC, Ju HY, Twu YK, et al. Optimized enzymatic synthesis of
caffeic acid phenethyl ester by RSM. N Biotechnol 2010; 27: 89–93.
7. Kurata A, Kitamura Y, Irie S, et al. Enzymatic synthesis of caffeic acid
8. Yagmurca M, Erdogan H, Iraz M, et al. Caffeic acid phenethyl ester as
a protective agent against doxorubicin nephrotoxicity in rats. Clin
Chim Acta 2004; 348: 27–34.
9. Chlopcikova S, Psotova A, Miketova P, et al. Chemoprotective effect
of plant phenolics against anthracycline-induced toxicity on rat
cardiomyocytes part II. Caffeic, chlorogenic and rosmarinic acids.
Phytother Res 2004; 18: 408–413.
10. Fadillioglu E, Oztas E, Erdogan H, et al. Protective effects of caffeic
acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats.
J Appl Toxicol 2004; 24: 47–52.
11. Fadillioglu E, Erdogan H, Iraz M, et al. Effects of caffeic acid
phenethyl ester against doxorubicin-induced neuronal oxidant injury.
Neurosci Res Commun 2003; 33: 132–138.
12. Lin YH, Chiu JH, Tseng WS, et al. Antiproliferation and radiosensiti-
zation of caffeic acid phenethyl ester on human medulloblastoma cells.
Cancer Chemother Pharmacol 2006; 57: 525–532.
13. Ozen S, Akyol O, Iraz M, et al. Role of caffeic acid phenethyl ester, an
active component of propolis, against cisplatin-induced nephrotoxicity
in rats. J Appl Toxicol 2004; 24: 27–35.
14. Yilmaz HR, Uz E, Altunbasak A, et al. Anticlastogenic effect of
caffeic acid phenethyl ester on cisplatin-induced chromosome
aberrations in rat bone marrow cells. Toxicol Ind Health 2010;
26: 33–37.
15. Iraz M, Ozerol E, Gulec M, et al. Protective effect of caffeic acid
phenethyl ester (CAPE) administration on cisplatin-induced oxidative
damage to liver in rat. Cell Biochem Funct 2006; 24: 357–361.
16. Yilmaz HR, Sogut S, Ozyurt B, et al. The activities of liver adenosine
deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes
and the levels of malondialdehyde and nitric oxide after cisplatin tox-
icity in rats: protective effect of caffeic acid phenethyl ester. Toxicol
Ind Health 2005; 21: 67–73.
17. Kizilay A, Kalcioglu MT, Ozerol E, et al. Caffeic acid phenethyl ester
ameliorated ototoxicity induced by cisplatin in rats. J Chemother 2004;
16: 381–387.
18. van't Land B, Blijlevens NMA, Marteijn J, et al. Role of curcumin and
the inhibition of NF-kappa B in the onset of chemotherapy-induced
mucosal barrier injury. Leukemia 2004; 18: 276–284.
19. Uzar E, Sahin O, Koyuncuoglu HR, et al. The activity of adenosine
deaminase and the level of nitric oxide in spinal cord of methotrexate
administered rats: Protective effect of caffeic acid phenethyl ester.
Toxicology 2006; 218: 125–133.
20. Oktem F, Yilmaz HR, Ozguner F, et al. Methotrexate-induced renal
oxidative stress in rats: the role of a novel antioxidant caffeic acid
phenethyl ester. Toxicol Ind Health 2006; 22: 241–247.
21. Uzar E, Koyuncuoglu HR, Uz E, et al. The activities of antioxidant
enzymes and the level of malondialdehyde in cerebellum of rats sub-
jected to methotrexate: protective effect of caffeic acid phenethyl ester.
Mol Cell Biochem 2006; 291: 63–68.
22. Armagan A, Uzar E, Uz E, et al. Caffeic acid phenethyl ester modu-
lates methotrexate-induced oxidative stress in testes of rat. Hum Exp
Toxicol 2008; 27: 547–552.
23. Uz E, Oktem F, Yilmaz HR, et al. The activities of purine-catabolizing
enzymes and the level of nitric oxide in rat kidneys subjected to metho-
trexate: protective effect of caffeic acid phenethyl ester. Mol Cell
Biochem 2005; 277: 165–170.
24. Cakir T, Ozkan E, Dulundu E, et al. Caffeic acid phenethyl ester
(CAPE) prevents methotrexate-induced hepatorenal oxidative injury
in rats. J Pharm Pharmacol 2011; 63: 1566–1571.
25. Ozyurt H, Sogut S, Yildirim Z, et al. Inhibitory effect of caffeic acid
phenethyl ester on bleomycine-induced lung fibrosis in rats. Clin Chim
Acta 2004; 339: 65–75.
26. Albukhari AA, Gashlan HM, El-Beshbishy HA, et al. Caffeic acid
phenethyl ester protects against tamoxifen-induced hepatotoxicity in
rats. Food Chem Toxicol 2009; 47: 1689–1695.
27. Linard C, Marquette C, Mathieu J, et al. Acute induction of inflam-
matory cytokine expression after gamma-irradiation in the rat: effect
of an NF-kappaB inhibitor. Int J Radiat Oncol Biol Phys 2004;
58: 427–434.
28. Yildiz OG, Soyuer S, Saraymen R, et al. Protective effects of caffeic
acid phenethyl ester on radiation induced lung injury in rats. Clin
Invest Med 2008; 31: E242–E247.
29. Lee YY, Kao CL, Tsai PH, et al. Caffeic acid phenethyl ester preferen-
tially enhanced radiosensitizing and increased oxidative stress in
medulloblastoma cell line. Childs Nerv Syst 2008; 24: 987–994.
30. Gremy O, Benderitter M, Linard C. Caffeic acid phenethyl ester modi-
fies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the
442s. akyol ET AL.
Copyright © 2012 John Wiley & Sons, Ltd.
Cell Biochem Funct 2012; 30: 438–443.
Page 6
rat by modulating the cytokine pattern. World J Gastroenterol 2006;
12: 4996–5004.
31. Chen MF, Keng PC, Lin PY, et al. Caffeic acid phenethyl ester
decreases acute pneumonitis after irradiation in vitro and in vivo.
BMC Cancer 2005; 5: 158.
32. Chen YJ, Liao HF, Tsai TH, et al. Caffeic acid phenethyl ester prefer-
entially sensitizes CT26 colorectal adenocarcinoma to ionizing radi-
ation without affecting bone marrow radioresponse. Int J Radiat Oncol
Biol Phys 2005; 63: 1252–1261.
33. Chen MF, Wu CT, Chen YJ, et al. Cell killing and radiosensitization
by caffeic acid phenethyl ester (CAPE) in lung cancer cells. J Radiat
Res (Tokyo) 2004; 45: 253–260.
34. Rahman I, MacNee W. Regulation of redox glutathione levels and
gene transcription in lung inflammation: therapeutic approaches. Free
Radic Biol Med 2000; 28: 1405–1420.
35. Wang SH, Chen CS, Huang SH, et al. Hydrophilic ester-bearing
chlorogenic acid binds to a novel domain to inhibit xanthine oxidase.
Planta Med 2009; 75: 1237–1240.
36. Yoshizumi K, Nishioka N, Tsuji T. The xanthine oxidase inhibitory
activity and hypouricemia effect of the propolis in rats. Yakugaku
Zasshi-J Pharmaceut Soc Japan 2005; 125: 315–321.
37. Basini G, Baioni L, Bussolati S, et al. Antiangiogenic properties of an
unusual benzo[k,l]xanthene lignan derived from CAPE (caffeic acid
phenethyl ester). Invest New Drugs 2012; 30: 186–190.
38. Hwang HJ, Park HJ, Chung HJ, et al. Inhibitory effects of caffeic acid
phenethyl ester on cancer cell metastasis mediated by the down-
regulation of matrix metalloproteinase expression in human HT1080
fibrosarcoma cells. J Nutr Biochem 2006; 17: 356–362.
39. Wang T, Chen LX, Wu WM, et al. Potential cytoprotection: antioxidant
defence by caffeic acid phenethyl ester against free radical-induced
damage of lipids, DNA, and proteins. Can J Physiol Pharmacol 2008;
86: 279–287.
40. Nomura M, Kaji A, Ma W, et al. Suppression of cell transformation and
induction of apoptosis by caffeic acid phenethyl ester. Mol Carcinog
2001; 31: 83–89.
41. Colburn NH, Wendel EJ, Abruzzo G. Dissociation of mitogenesis and
late-stage promotion of tumor cell phenotype by phorbol esters:
mitogen-resistant variants are sensitive to promotion. Proc Natl Acad
Sci U S A 1981; 78: 6912–6916.
42. Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radio-
sensitization of tumors by plant polyphenols. Antioxid Redox Signal
2005; 7: 1630–1647.
443caffeic acid phenethyl ester
Copyright © 2012 John Wiley & Sons, Ltd.
Cell Biochem Funct 2012; 30: 438–443.


text:
Erica Dixon is a certified personal trainer and group fitness instructor, and she enjoys teaching Zumba Fitness, Cycle, and Kickboxing just to name a few. She has been a licensed Zumba Fitness Instructor since 2008 and has been teaching classes in locations all over the triangle area. Erica is also a Zumba Jammer choreography specialist for Zumba Fitness instructors. As a ZJ, Erica conducts training sessions in NC and throught the US. Learn more about Erica Dixon here.
Have a question for Erica? Click here to contact Erica.
e-Fit4Life has many different events coming up. Join Erica Dixon at these events:
Nov. 23rd - Pre-Thanksgiving Burn Master Class - Wilmington, NC
Nov. 28th 9am-12pm - 4th Annual Turkey Burn Toy Drive Workout & Black Friday Z-Wear Mega Sale
Nov. 29th - Greenevers Volunteer Fire Department Fundraiser
Dec. 6th - Greatest Hits Master Class - Mebane, NC
Sept. 14-19, 2015 - Island Riddims 3 Cruise
#1 - Bethesda Elementary
#2 - Bethesda Comm. Gym
#3 - Learning Tots-RTP
Go to Class Schedule Tab for More Information!
I had the pleasure of meeting Erica when she ...
Read more

subset: commoncrawl


text:
Category Archives: Haste Podcast
Tact-Tiles Return, Breaking D&D is Bad, and is Ragequitting Okay?
Podcast: Play in new window | Download| Episode 119|
Congrats to our Fool contest winner, we had to pick 4 instead of 3 because it was so hard to decide! Our winning NPCs are Roger Larrabee (telepath), Barkley (fey guardian), Craig the Battle Droid (butler artillery), and Terrence McGoven (awkward helicopter pilot).
Additionally, we've got a brand new d20Monkey Caption Contest up, also be sure to check out Brian's new "Whining Is Coming" edition war T-shirt design.
Lastly, if you consider yourself a D&D history junkie be sure to read Ambush At Sheridan Springs – a story about how Gary Gygax lost D&D.
Haste! Minsc and Boo Get A Comic, 5e Starter Set Hands On, Survive The Night
Podcast: Play in new window | Download| Episode 118|
The d20Monkey caption contest has found itself a winner, be sure to stop by and check out the winning line, and also stay tuned for a new caption contest very soon. Also, if you enjoy Brian's work and want to help him transition into becoming an artist full time, please go check out his Patreon page and consider chipping in.
Also, our friend Justin Mason is part of the Adventure A Week Snow White Kickstarter which seems pretty cool if you ask us. Check it out and be sure to pass it on to any fellow Pathfinder players you might know
Haste! Game Night Noms, Subraces, Dungeon World, and Using 3rd Party Materials
Podcast: Play in new window | Download| Episode 117|
Caption contest will be finalized by our next episode, new comic is coming! Aside from that let's jump in and get talking!
Haste! Fear of Girls, D&D's Living Rules, Backstory Cards and More!
Podcast: Play in new window | Download| Episode 116|
We stumbled across these RPG Dice for the Visually Impaired, tell us if they are useful or not, we'd really like to know!
Haste! Codename Morningstar, Stealing from Games, Stealth and More!
Podcast: Play in new window | Download| Episode 115|
New features! Character & item filters, sortable adventure log dates, bug fixes and more.
Haste! D&D Starter Box and Organized Play, and Countdowns In Your Game.
Podcast: Play in new window | Download| Episode 114|
Congrats to our final Birthday Contest winner Lyle, with The Golden Dawn, also check out the Elicpse Phase bundle of holding!


text:
Eye Candy: California Love view
Eye Candy: Southern Sensation view
International Heartbreaker view
Reynolds has endured a lot of rumors and speculation about his sexuality before his marriage,...
Reynolds has endured a lot of rumors and speculation about his sexuality before his marriage, during and even still today.
"When it comes to people discussing my sexuality I've always taken the higher road," says Reynolds. "I get very emotional about it sometimes because I'm tired of the disrespect. It has affected my professional career and personal life."
Read our exclusive interview with Al Reynolds »
Customer Service | E-mail Newsletter Sign-up | Subscribe to Essence | Give a Gift of Essence | Change Your Address | Renew Your Subscription | Pay Your Bill | Questions & Comments
Bios | Contact Us | Essence Crosswords | Job Opportunities | Internships | Media Kit | Our Company | Site Map | Writer's Guidelines | Magazine Tablet Edition
© 2014 Essence Communications Inc. All Rights Reserved | Privacy Policy | Your California Privacy Rights | Terms of Use | Essence.com Advertising Terms | AD CHOICES


text:
Montreal Croissant Update Please
Do we understand that le Duc de Lorraine has changed hands? Would like very best croissant recommendation for end 2010 (and great coffee to go with, although that's not essential).
Le Pain dans les voiles makes a good croissant and chocolatine. The only issue is that they're not on the Big Croissant proper - they're in Mont-Saint-Hilaire.
I don't know if there's a best croissant... some are as good but just different. I like all of these :
- The newly opened Boulangerie Guillaume (already some of the finest bread in town too... the fougasse à la fleur de sel is amazing)
- Olive & Gourmando
- Le Paltoquet
- Fous Desserts
- Mamie Clafoutis
- Co'pains d'abord
I don't remember if I've tried the ones at Arhoma, but they're probably good as almost everything they do is.
re: wattacetti
On fairmount, just East of St-Laurent.
Haven't had a chance to try it yet, but it's on my list, I heard good things.
re: wattacetti
Which Co'pains are you referring to?
The one on Masson, I find, has very nice staff.
re: english muffin
Top marks:
Mr Pinchot - buttery and lightly sweet
Kouign Amann - compact and delicious
Le Paltoquet - thin and elegant with nice crisp
Autour d'un Pain - bigger and less buttery than above but great (crisp outer/middle ridge) altogether a different style
Low marks- Croissanterie Fairmount- pretty much phoning it in
My personal favourites are Kouign Amann and les Copains d'Abord as they make the kind of croissant I prefer: crisp and shiny on the outside, with dense and buttery layers of pastry on the inside. Olive and Gourmando is pretty good too, but their prices are too high if you ask me. Especially since their croissants a touch on the small side. When I go there I normally opt for something a little unusual - theres a danish with apricots, white chocolate, macadamia and coconut. The thing weighs a ton, but it's fantastic.
re: MonsieurMangetout
Where is Kouign Amann? The croissants sound good, but if they make a good kuoign amann I'll gladly make the 2 hour drive.
re: ProvoloneRanger
Near Mount-Royal metro:
322, avenue Du Mont-Royal Est
re: ProvoloneRanger
Their Kouign Amann is a little uncharacteristic but OUTSTANDING. One of the most delicious desserts (buttery, caramelly) in the city. But they're often sold out! Maybe call ahead before a long drive.
re: ProvoloneRanger
It's for sure worth the drive, the k.a. is amazing. If you call in advance, they can hold a whole k.a. for you. It's about a dozen individual pieces (or less if you cut it up yourself) and it reheats great for a couple of days ... as if!
re: RhondaB
Thanks, I think maybe a trip is in order after the holidays.
The Croissants aux Amande from Guillaume are probably the best one I ever ate!!!
I went in early this morning, and they were freshly done, crisp and tender, tons of roasted almonds, a little bit of caramelization on the bottom, just perfect!!!
The chausson aux pommes is not too shabby also!!!
BTW they are closing for 2 weeks (from the 4th to the 14th inclusive).
re: Maximilien
Ok, you have just convinced me to try their croissants. I have been loving their little chocolate breads (le petit ecolier) and their fougasses (the best deal in the city) but had passed over their croissants in favour of Fous Dessert's.
Another tip for a croissant - Bakery Arhoma makes a pistachio croissant! I haven't tried it personally but my friend raved about it. Although they can be hard to get a hold of - Copette and Cie, the cheese shop in Verdun that stocks Arhoma products, doesn't get them in every day, as their production is dependant on how many croissants were not sold in the bakery the previous day!
re: unlaced
My friend has been raving about the breads at Copette and Cie, maybe a visit to Arhoma is in order. Is this their address:
Arhoma Boulangerie Fromagerie Inc
15 Simon Valois Place, Montreal, QC H1W 0A6
re: AlexCV
I really like the croissants and the almond croissants from La Cannoise (1301 Ontario East @ de la visitation).
re: pinkatronica
Can someone tell me why no one ever mentions Claude Postel when it comes to croissants? We visit once a year and always make a stop...for croissants and other things.
Should I be going to somewhere even better??? Thanks!
I just had a wonderful chocolatine from La Mie Matinale (www.lamiematinale.ca
)The pastry was really tender and flaky, and it had 2 bars of chocolate so every bit had some. I went there for the stollen and just grabbed the chocolatine on a whim and I'm so glad I did! They also have plain and almond croissants, that I'll have to try next time...
My favorite croissants come from the AMOUR DU PAIN bakery in Boucherville and are delivered every morning at FOU D ICI, 360 Maisonneuve West, (corner of Bleury) in Montreal.
Le comptoire du chef on Metcalf is not a bakery but they manage to make excellent buttery croissants.


text:
Five Centennial High School students received National Merit Scholarship Program Letters of Commendation in recognition of their outstanding academic promise.
The Multiple Measurements Rating (MMR) results are in! Centennial schools performed well, with Centennial High School ranking third in the state and the two Title I schools, Centennial Elementary and Golden Lake Elementary, earning "Reward School" status for the second year in a row.
Hall of Famer and Supreme Court Associate Justice Alan Page addressed Centennial High School students on preparing for the future.
Lawrence Biehn, Robert McMorran and Ruth Roth are inducted into the Centennial Hall of Fame for Distinguished Service. Tony Smeed ('89) is inducted as Distinguished Alumnus.
District Office: 4707 North Road, Circle Pines, MN 55014 Tel: 763-792-6000Serving the communities of Blaine, Centerville, Circle Pines, Lexington and Lino Lakes in Minnesota
Centennial School District does not discriminate (School Board Policy #5000)© 2012. Centennial School ISD 12


text:
Movie extras needed Saturday morning
Updated On: Jul 07 2014 10:10:00 AM EDT
The Coastal Georgia Film Alliance is seeking volunteer extras to participate in a film called The Race, to be filmed by Tandem Media on Saturday in St. Marys.
People of all ages are welcome to play the roles of spectators or runners in a race organized by the city fathers as part of the plot for this family-friendly production.
Filming will begin at 6 a.m. and participants should be at the Howard Gilman Memorial Waterfront Park near the amphitheater before then.
Producers request that all extras be sure and not wear clothing with brand logos. Participants are encouraged to bring their own coolers, blankets, hats, sunscreen, and beach chairs -- whatever they would normally bring to watch a race or run in one.
Anyone interested in being an extra can email email@example.com or just show up on Saturday before 6 a.m. Families are encouraged.
To get to the Waterfront Park, take Georgia Exit 3, turn left and go about 9 miles to end of road and turn right.
The views expressed below are not those of News4Jax or its affiliated companies. By clicking on "Post," you acknowledge that you have read the Terms of Service and your comment is in compliance with such terms. Readers, please help keep this discussion respectful and on topic by flagging comments that are offensive or inappropriate (hover over the commenter's name and you'll see the flag option appear on right side of that line). And remember, respect goes both ways: Tolerance of others' opinions is important in a free discourse. If you're easily offended by strong opinions, you might skip reading comments entirely.


text:
Search results for Karrueche Chris Brown
Bangers: Karrueche Talks Chris Brown Rumors And Homegirl Christina Milian Talks Lil Wayne Date [Video]
Look… We've had a thing for C-Milli since the first time we laid eyes on her. But, is she an airhead?
They Good Y'all, I Swear: Karrueche's Manager Denies Chris Brown Breakup Rumors
"Rumors are funny"–Jacob York
Happy Ending? Karrueche "Relieved" A Nervous Chris Brown Prior To His Performance At BET Awards
Relax ya mind, let ya conscious be free, you did time in the bing, this is just BET…
Booty Had Me Like: Chris Brown Shows Off Karrueche's Oiled Up Cakes In A 'Kini
Daaaayyum lil mama….who knew Kae was working with all that?!?
Ride-Or-Die…Literally: Chris Brown Flicks It Up In The Car With Karrueche And Talks About Her 'Scary' Driving Skills
Krunchy Kae Kae must be a bad behind the wheel…
Hi Rihanna: Chris Brown Posts A Lil' PDA For His Ride-Or-Die Chick Karrueche On Instagram
Guess at least SOME of these hoes are loyal
Loyal: Chris Brown Professes His Love For Karrueche Again In Heartfelt Speech & Hits The Studio
Breezy Been Eating Good In The Bingski: Chubby Lumpkins Chris Brown Parties With Crunchy Karrueche At Welcome Home Party
Aren't you supposed to lose weight in jail???


text:
|Missouri Miniature Pinscher Rescue
|Miniature Pinscher Rescue Groups
|New Location ▼
|Change Breed ▼
|Find a Home for an Animal ▼
|Rescue Alerts ▼
|Donate to Miniature Pinscher Rescue as a gift or memorial, and we will mail a free acknowledgement card within 24 hours.
3,378 Miniature Pinscher Dogs have been adopted on Rescue Me!
|Missouri Miniature Pinscher Dogs for Adoption
|Page 1
|Options: Reset
|Rescue Me ID: 14-10-17-00791Drax (male)
Meet Drax! This little guy is energetic and loves to sit in your lap. He loves the ladies, but he's a little shy around men. When he's in his kennel he likes to burrow into his blankets. Drax is around 1 year old and a Dachshund / Miniature Pinscher mix. He is Neurtered, Heartworm Negative, Vaccinated and Microchipped. His adoption fee is $200.00 Interested? Go to www.DogsbyDebin.com and complete an Adoption Application today!
Dogs by Debin
9300 NW 87th Terr
Platte County Kansas City, MO 64153 MAP IT!
|Rescue Me ID: 14-10-06-00139Bosley (male)
DOB: 4/24/11,Approx.. Weight: 20 Lbs. $175 adoption fee includes a 2 week trial to ensure everyone's happiness! Bosley originally came to Furry Kids' as a puppy and was returned as a young adult. The family was worried that the high activity of young children in the household made him nervous and was causing him stress. We were told Bosley's mother was a Cocker Spaniel and we do not know what his father was, possibly Miniature Pinscher or Chihuahua, or Terrier? Bosley is now in a foster home with many other dogs. He is curious and friendly and having fun! Bosley is housebroken and crate trained. He is very well behaved and fairly ... (Read More)active (especially outside). He does like to play fetch and does enjoy investigating in the back yard. He would do best with a fence to keep him safe and his nose in line! Bosley also loves to go on walks and does great on the leash! Bosley does growl at other dogs who approach his crate when he is eating, but that is not uncommon. His foster Mom said that when all dogs are getting treats there are no issues. Bosley loves to play with dogs his size and smaller! Please no small children or highly active households for Bosley. Families with teenage children or older would be best for Bosley, another companion dog would make him happy as well, but not necessary. Bosley has been neutered, vaccinated, heartworm tested negative, and microchipped. If you are interested in adopting Bosley, please complete the adoption application located at www.furrykidsrefuge.org/adoptadog and a dedicated volunteer will get back to you as soon as possible (Less)
Furry Kids' Refuge
Lee's Summit, MO 64063 MAP IT!
|Rescue Me ID: 13-12-15-00411Brooks (male)
We were told Brooks is a Min Pin mix but its hard to know for sure....he has the size, the stubby tail and the energy of one !!! Brooks was released to Furry Kids' Refuge from a family who couldn't take him with them when they moved. Brooks was in a home with school age children and a big Lab that he loved dearly. He is such a sweet, loving little dog. The family told us he was housebroke and we know he is crate trained because he is in our boarding facility waiting for a foster home to open up and never soils in his kennel. Brooks rides really well in the car and even does well walking on a leash. Brooks would do best in a home without ... (Read More)kitties....he doesn't understand that cats are more fragile than dogs, so he wants to play with them and chew on them like he does with his doggie playmates. So he would be too rough with cats and could unintentionally hurt them. Please give this little furry kid a chance to enrich your life by filling out a application to meet/adopt him. Brooks has been neutered, vaccinated, heartworm tested negative and microchipped. He is also on monthly heartworm prevention to help ensure he remains healthy. If you are interested in adopting Brooks, please fill out an adoption application located at www.furrykidsrefuge.org/adoptadog and a dedicated volunteer will get back with you as soon as possible. (Less)
Furry Kids' Refuge
|Check All That Apply Duplicate Post Spam/Possible Scam Inappropriate Photo Wrong Phone Number My Calls Not Returned
No Response to My Email "+JSVpcv+" Breeder Selling Animals (Posing as Rescue) Cancel
|Your problem report has been received. Thank you for helping keep this site accurate.
|How do you know this animal is no longer available?
This is my posting. I adopted this animal. Someone told me by phone or email. My calls or emails were never responded to. Other.
What is the current status of this animal?
Adopted (found a permanent home). Euthanized. Unknown. Other.
Cancel Cancel
|This animal has been reported as no longer available. Thank you for helping keep this site updated.
|Your information:
First Name: Last Name:
Your Email:
Send posting to my own email.
|Email this posting to up to three friends at once:
Friend 1 First Name: Email:
Friend 2 First Name: Email:
Friend 3 First Name: Email:
Send posting to yourself or fill in one, two or three friends above then hit... Cancel
|This posting has been sent successfully.
|PIease Read Before Adopting a Miniature Pinscher in Missouri
Miniature Pinscher Dogs can make good pets in Missouri if they match your IifestyIe. Miniature Pinschers are lively little terriers that need to be the center of attention. Miniature Pinschers get along well with other pets and children if properly socialized, but they do not tolerate teasing. Miniature Pinschers are intelligent, quick learners. This breed can live in an apartment if it gets enough exercise, including being taken for a brisk walk each day. Miniature Pinschers do not tolerate cold temperatures well.
Rescue Me! - HeIpingAnimaIs in Need.
|♥ This page is in fond memory of these Miniature Pinscher Dogs who are no longer with us... ♥
If you have experienced the loss of a beloved pet, or if you know someone who has... [POST A MEMORIAL HERE]
|Help Spread the Word! Please link to Missouri Miniature Pinscher Rescue from your website.
Rescue Me! Website
Follow @RescueMeOrg
Miniature Pinscher Page
Follow @MinPinDogRescue


text:
Already a Bloomberg.com user?
Sign in with the same account.
Don't have an account?
Sign up.
Help! I can't access my account.
Dec. 8 (Bloomberg) -- Scott Wren, senior equity strategist at Wells Fargo Advisors, talks about the outlook for global markets and financial stocks.
Wren speaks with Betty Liu and Dominic Chu, on Bloomberg Television's "In the Loop." (Source: Bloomberg)
On Air Now
The Pulse
Watch Now
Bloomberg Surveillance
©2014 Bloomberg L.P. All Rights Reserved. Made in NYC
Ad Choices


text:
новости на русском
azərbaycan dilində
Main page
Latest News
Arts & Entertainment
Eurovision 2012
World news
Weird / Interesting
Photo Galleries
Voice of Diaspora
Your Corner
Weird / Interesting
Google kicks driver out of its new car
18 August 2014 [13:00] -
The car stopped at stop signs. It glided around curves. It didn't lurch or jolt. The most remarkable thing about the drive was that it was utterly unremarkable.
This isn't damning with faint praise. It's actually high praise for the car in question: Google Inc.'s driverless car.
Most automotive test drives (of which I've done dozens while covering the car industry for nearly 30 years) are altogether different.
There's a high-horsepower car. A high-testosterone automotive engineer. And a high-speed race around a test track by a boy-racer journalist eager to prove that, with just a few more breaks, he really could have been, you know, a NASCAR driver.
This test drive, in contrast, took place on the placid streets of Mountain View, the Silicon Valley town that houses Google's headquarters.
The engineers on hand weren't high-powered "car guys" but soft-spoken Alpha Geeks of the sort that have emerged as the Valley's dominant species. And there wasn't any speeding even though, ironically, Google's engineers have determined that speeding actually is safer than going the speed limit in some circumstances.
"Thousands and thousands of people are killed in car accidents every year," said Dmitri Dolgov, the project's boyish Russian-born lead software engineer, who now is a U.S. citizen, describing his sense of mission. "This could change that."
Dolgov, who's 36 years old, confesses that he drives a Subaru instead of a high-horsepower beast. Not once during an hour-long conversation did he utter the words "performance," "horsepower," or "zero-to-60," which are mantras at every other new-car test drive. Instead Dolgov repeatedly invoked "autonomy," the techie term for cars capable of driving themselves.
Google publicly disclosed its driverless car program in 2010, though it began the previous year. It's part of the company's "Google X" division, overseen directly by co-founder
Sergey Brin and devoted to "moon shot" projects by the Internet company, as Dolgov puts it, that might take years, if ever, to bear fruit.
So if there's a business plan for the driverless car, Google isn't disclosing it. Dolgov, who recently "drove" one of his autonomous creations the 450 miles (725 km) or so from Silicon Valley to Tahoe and back for a short holiday, simply says his mission is to perfect the technology, after which the business model will fall into place.
Print version
Views: 759
Connect with us. Get latest news and updates.
Follow @TRENDNewsAgency
Recommend news to friend
Your name:
Your e-mail:
Friend's name:
Friend's e-mail:
See Also
05 November 2014 [16:56]
Hasn't worn shoes or socks in almost 50 years
30 October 2014 [14:37]
These oak sticks make your cheap whiskey taste more expensive
27 October 2014 [16:59]
Apple Variety Aptly Named 'Surprize' Hidest Pink Surprise Inside
21 October 2014 [16:10]
Menswear Model for Famous Clothing Brands
15 October 2014 [15:10]
Meet Garfi, the angriest cat on the internet
15 October 2014 [11:50]
Facebook founder to donate $25 Mln to fight Ebola epidemic
14 October 2014 [13:40]
Each member of Mercedes staff to get a minimum bonus payout of £10,000
09 October 2014 [17:04]
Spiders have reached the stone age
09 October 2014 [14:46]
Chinese tycoon gifts iPhone 6 to his classmates
08 October 2014 [16:45]
Samsung slump echoes demise of rivals BlackBerry and Nokia
Most Popular
Armenia's aggressive policy isolates it from economic projects
President Ilham Aliyev received the CEO of BBC Global News
Days of Turkish Culture kicks off in Baku
Azerbaijan completely ready for emergency cases
Azerbaijan, a regional hub for delicious foods
Iranians rush to hospitals after acid rains
FAO office to open in Baku
Contact us: firstname.lastname@example.com
Copyright © 2005-2014 Today.Az


text:
A number of storms recently brought heavy rains to the northern region of Haiti, flooding thousands of homes and causing damage to crops and livestock. Over 800 children and their families have been affected by this crisis.
A house fire recently broke out in Cebu City and the fire quickly spread and destroyed many homes. 33 children from Heaven's Joy Student Center (PH-906) have lost their homes.
Weeks of heavy rain has caused mudslides and flooding in Managua, Nicaragua. More than 40 children and their families from NI-127, NI-134, NI-245, NI-247, NI-250 were affected.
A cyclone recently hit the east coast of India causing damage to homes. Children from EI-421, EI-433, and EI-457 were impacted.
More than 75 children, along with several church staff at Agape Student Center (HO-131) in the Villa de San Francisco area of Honduras have been affected by a recent outbreak of chikungunya virus.
Recently, a 7.4 magnitude earthquake struck off the coast of El Salvador. Children from projects ES-704, ES-707, ES-717, ES-780, ES-803, ES-811, ES-831, ES-833, ES-877, and ES-940 have been affected.
More than 130 children, along with several church staff, at Siloe Integral Development Center (CO-529) in Cartagena have been affected by a recent outbreak of chikungunya virus.
The families of seven children from GH-629 Kpoviadzi Child Development Center have been affected by recent flooding in the southeastern Volta region of Ghana. The church staff is working to distribute relief items to the affected families.
The majority of Compassion beneficiaries and their families are home now. Our church partners continue to provide assistance where necessary.
Heavy rains caused flooding to occur in south Manado Indonesia. ID-245 and ID-229 have been impacted.
Compassion is working with country health officials in Ghana, Togo, and Burkina Faso to stay informed about the Ebola outbreak and the potential impact on the children and families we serve. To date, no Compassion staff or children have been affected.
Heavy rains have caused flooding to occur in the Punjab state of India. The homes of 35 children from IN-928 were damaged.
Heavy rains and strong winds damaged buildings near the town of Pijijiapan in Chiapas, Mexico. The homes of eight children were damaged. No injuries have been reported.


text:
30% off Annual Legal Plan
30% off on all annual legal plans. Restrictions may apply.
$20 off Legal Needs with Total Legal Care Plan
Click on this link to get a $20 discount on your legal needs when you sign up for Legal care plan. No code needed.
Save $180 on Velocity Annual Plan Promo
Click on this link to get $180 discount when you buy Velocity annual plan. No code needed.
40% off Standard Hourly Attorney Fees
Click through this link to get 40% discount on standard hourly attorney fees. Check site for details.
10% off Personal Injury Contingency Fees
Click on this link to get 10% discount on personal injury contingency fees. No code needed. Limited time offer. See link foe more details.
50% off First Month Purchase
Use this code at checkout and get a 50% discount on your first month purchase. Restrictions apply.
50% off Your First Monthly Purchase
Enter code at checkout to get a 50% discount on your first monthly purchase. Some restrictions may apply.
$5 off 1st Month of Personal Membership
Get $5 off your first month of a Personal Membership when you follow the link and enter the code at checkout.
Save $20 on Membership
Click this link to automatically save $20 on the Easy Legal Care membership. No code entry required.
Save money on legal services by signing up for Rocket Lawyer's monthly plan, which includes step by step help with legal document preparation, legal questions answered by real lawyers, and deep discounts should you actually need in-person legal representation.
Oftentimes, Rocket Lawyer will have coupon codes good for 50% off your first month of service, or 30% off an entire year.
Tons of free legal forms to fill out are available on their site. Click around and make sure you need to buy a membership to get the legal help you need before spending any money.
They also offer a free 30 day trial membership of all of their services, so you can try before you buy.
Tips courtesy of CouponMama
Rocket Lawyer DealPro for 8 years
These deals last checked 5 months ago
Though you won't be appearing in Space Court in front of galactic tribunals any time soon, Rocket Lawyer certainly embodies the legal wave of the future. Whether you're a lawyer looking to increase your earnings potential or a client seeking advice from lawyers in your area, they provide hands-on, legal services at affordable prices. Launched towards the end of 2007 their goal i to make legal services easier and more affordable for everyone. For lawyers, Rocket Lawyer provides an excellent opportunity to jump-start their practice with a customizable online profile that allows clients to actively seek their legal expertise. For clients, this is a one stop shop for legal services made easy. Simply answer questions set forth by their Easy Legal Care program and they take care of the rest. For even greater deals, bring a Savings.com coupon code with you as you explore the site.
Though you won't be appearing in Space Court in front of galactic tribunals any time soon, Rocket Lawyer certainly embodies the legal wave of the future. Whether you're a lawyer looking to increase your earnings potential or a client seeking advice from lawyers in your area, they provide hands-on, l...


text:
We Have a Multi-threaded Application in JAVA which has multiple threads running in parallel. Now we want to run all these threads on a single core. Currently application is running on a system having more then one Cores.
We know there is a technique available ProcesAffinity in .Net Framework to set process affinity.
But we don't want to depend on .Net Framework, because our application is build in java.
Do we set Process affinity using Bat file and run our application executable jar file through Bat file?
Currently our application is running on Window XP. So we need a solution that should be working fine on XP platform.


text:
Find records of Constance Andeen
Find birth, death, marriage, military, and other records of Constance Y Andeen at Ancestry.com.Search for records
Biography & Family History Add details
Constance Y Andeen (1920 - 1993) was born on September 20, 1920. She was born into the Andeen family.
Constance had no-known relationships. Constance died in October 1993 at 73 years of age.
Constance Y Andeen's last known residence is at Rockford, Winnebago County, Illinois.
This record of Constance Y Andeen comes from the United States Social Security Death Index. What is the SSDI?
This look at Constance Y Andeen's life is a collaborative effort by the AncientFaces community Add any information you have to reach the people who knew her. Some common things we would like to know about Constance's genealogy:
- Where was Constance born?
- Where did Constance die?
- Who was Constances family?
- What did Constance look like? Add some photos of their life.
Family Tree & Genealogy Add / Edit People
You can add or remove people from this genealogy by clicking here.
History of Constance Y Andeen Add details
- Given name
- Constance
- Surnames
- Andeen family history
- Last Known Residence
- Rockford, Winnebago County, Illinois
- Born
- Death
- Gender
- Female
Do you know more about Constance Y Andeen?
You can add details to this page and share Constance's story.
Obituary Add details
No one has entered any info on the obituary records of Constance Y Andeen. You can add obituary information about Constance Y Andeen by clicking "Add Details".
Discuss Constance
Share your memories below with the rest of Constance's family. We'll notify anyone else who is searching for Constance of your message.
Find records of Constance Andeen
Find birth, death, marriage, military, and other records of Constance Y Andeen at Ancestry.com.Search for records


text: A recessive mutant allele, vermillion, causes bright orange eyes in Drosophila when homozygous. The usual color is red. What happens when a vermillion female fly is crossed to a red male fly whose father was vermillion? Why? Here are data pertaining to red vs brown eye color in Drosophila. Given the data, what can you say about the mode of inheritance of brown vs. red (wild type) eye color? What about the genotypes of the sets of parents, and of the offspring? offspring: red brown parents: brown x brown 0 92 red x red 79 0 red x red 64 21 red x brown 100 0 red x brown 54 60 Pigeons may be checkered or plain. In a series of matings, the following data were obtained: Checkered Plain a) checkered x checkered 36 0 b) checkered x plain 38 0 c) plain x plain 0 35 The F1 were mated with these results (parental cross is indicated in parentheses) F1 x F1 Crosses (parentals) F2 Progeny Checkered Plain 1) checkered (a) x plain (c) 34 0 2) checkered (b) x plain (c) 17 14 3) checkered (b) x checkered (b) 28 9 4) checkered (a) x checkered (b) 39 0 How are checkered and plain inherited? Which allele is dominant? What are the parental genotypes? Determine genotypes of parents and offspring for each cross. http://www.vdperre.be/duiven/formerpigeons.html A red swordtail with crescent spot was crossed to true-breeding olive spotless fish and the following progeny obtained: 15 red spot,13 red spotless,16 olive spot,14 olive spotless a. What can we conclude about the inheritance; what are the parental genotypes? b. Create symbols for alleles, write out parental genotypes c. Write out genotypes of progeny


text:
Kaley Cuoco Shows Off Her Tennis Skills
7 Things You Didn't Know About 'The Big Bang Theory'
14 Shows We Wish Were Still On Air
This Amazing Drink Is Stunning the Weight Loss Industry
8 Historical Facts That Will Change Your Concept of Time Forever
The Real Lorde Sings South Park's Lorde Parody Song and I's Amazing
KKTH Sneak Peek: Scott Disick Checks Into Rehab
'The View' Has Very Heated Debate Over Bill Cosby Allegations
What The Average American Male's Body Looks Like
Major Networks Not Airing Obama's Immigration Speech
15 People Who Have Been Banned from SNL
Soap Actor's Suicide Linked to His Dog
27 Fascinating Movie Facts You Never Knew
25 Awesome Behind the Scenes Photos From 80s Movies
30 Times You've Seen The Walking Dead Actors Before
The Hottest Women from Game of Thrones
Kerry Washington Spills Exclusive Scandal News
Why 'Sex Tape' Sucks
Alison Sweeney Pens Heartfelt Goodbye Message to Fans
The Hottest Actresses on Primetime Television
Soap Star Eileen Davidson's New Real Housewives Gig
Marvel's DareDevil Reveals First Stills, Costume & Cast
Is Katherine Kelly Lang Leaving B&B?
Kella Ripa Cracked The Best Dirty Joke On Live TV
10 Things That Still Bother You About "Friends"
7 Racy Shows to Watch While You Wait For '50 Shades of Grey' Movie
Bangin' Big Bang Theory Facts You Need to Know
Will The Hulk Come Back?
The Bold and The Beautiful Loses a Featured Actress


text:
Yo-Yo Ma is a Grammy-winning American Chinese cellist.Yo-Yo Ma was named United Nations Messenger of Peace in 2006 to promote the Organization's values among young people.
Charities & foundations supported
None known - if you know of one, please drop us an email
Other supporters of the same charities & foundations
No celebrities are known to support the same charities.
1 related place
Google trends for "Yo-Yo Ma"
Available to Insiders only
Causes supported
None known - if you know of one, please drop us an email
Contact Yo-Yo Ma
You can contact Yo-Yo Ma using details from this service. (Or read our advice on how to contact celebrities)


text:
| Hyde park hotel London | midrange hotels London Paddington | two 2 star midrange hotel London Paddington |
Just a short distance from Hyde Park, on a leafy boulevard near Paddington railway and underground station, meeting point for trains arriving from Heathrow airport and the tube lines for the West End, the City and all the most beautiful and interesting places to visit, the Mitre House Hotel is the ideal solution for business and tourist stays in the heart of London.
An enchanting historic building, with stylish and comfortable rooms, bar, 24h reception, generous breakfast, Wi-Fi, free parking and many other modern facilities, making it one of the best-loved 2-star Hotels in the Hyde Park area.
Special offers
From January 01 2014 to December 31 2014
For online reservations booked at ...
Events in London and surroundings
From November 21 2014 to January 04 2015
Hyde Park Winter Wonderland ...
From May 07 2014 to January 01 2015
London is one of the ...


text:
The spectacular 481-acre beachfront resort is Puerto Rico's new premier meeting, incentive, and sports destination. It features the magnificent Oceanfront Conference Center, the Caribbean's largest ballroom, acres of lush outdoor function space, 600 luxurious rooms and suites, two championship golf courses, a tennis center, water sports, Westin's world-renowned service, a spa and fitness center, a casino, KIDS CLUB, and ten superlative restaurants, lounges, and entertainment venues. Local ...
Register for Complete Access (Valid Email Required)
By registering on MeetingsNet now, you'll not only gain access to Printer-friendly, you'll get exclusive access to a large archive of premium content.
Already registered? Log In here.


text:
Tag: apple vs samsung tablets
iPad vs. Samsung tablets visualized
Having just launched a new pair of iPad competitors last week, Samsung's tablet arsenal seems to be growing at an exponential rate. To get a better idea of just how many weapons Samsung is stockpiling in its attempt to lure customers away from Apple's much more popular tablets, I gathered a list...
Subscribe to Newsletter
Software Updatesmore updates
- Vizzywig 8xHD price tag now a very affordable $49.99
- Automatic targets teen drivers with License+ service
- Dropbox adds support for TouchID
- YouTube for iOS gets updated with full support for iPhone 6 and 6 Plus
- iOS 8.0.1 update now available (Updated -- Don't update!)
- NFL Mobile updated for 2014 Season with new Fantasy Football features, NFL Now integration


text:
Choose your preferred language. We speak English and 41 other languages.
Most often used by people in the United States
All languages
FREE cancellation on most rooms!
Instant confirmation when you reserve
|Villa Daniela Ul. Krap. Spuzvara 8, 22010 Brodarica, Croatia (0.4 miles from Krapanj)
Score from 18 reviews: Very goodA charismatic hotel with comfortable modest rooms leading to spacious balconies: Daniela is in an ideal location from which to reach 3 national parks and numerous other tourist attractions. More…
$41 Average price per night
|Apartments Ankica Katarine Zrinske 2 , 22000 Šibenik, Croatia (1.9 miles from Krapanj)
Score from 37 reviews: Very goodApartments Ankica offers air-conditioned accommodation with satellite TV, free Wi-Fi and a furnished balcony. More…
$61 Average price per night
|Apartments Jasminka Ante Šantića 15, 22000 Šibenik, Croatia (4.5 miles from Krapanj)
Score from 66 reviews: ExcellentApartmani Jasminka can be found in various places in the centre of Šibenik, all close to St. Jacob Cathedral. They feature a fully equipped kitchen and a private bathroom. Most offer free Wi-Fi. More…
$50 Average price per night
|Medulić Palace Rooms & Apartments Ivana Pribislavica 4, 22000 Šibenik, Croatia (4.5 miles from Krapanj)
Score from 177 reviews: ExcellentLocated in Šibenik city centre, this family-run guest house offers stylish rooms with free Wi-Fi, flat-screen TVs and large beds. More…
$56 Average price per night
|Apartments Kokolo Nove Crkve 24, 22000 Šibenik, Croatia (4.5 miles from Krapanj)
Score from 65 reviews: ExcellentLocated in the historic core of Šibenik and 500 metres from the nearest beach, Apartments Kokolo features air-conditioned accommodation with free Wi-Fi and LCD cable TV in all units. More…
$61 Average price per night
|Apartments Nove Crkve Nove Crkve 18, 22000 Šibenik, Croatia (4.5 miles from Krapanj)
Score from 49 reviews: Excellent There is 1 person looking at these apartments.Located within Šibenik Old Town, just 200 metres from the UNESCO-listed St. Jacob Cathedral, Apartments Nove Crkve offers free Wi-Fi. More…
$75 Average price per night
We've negotiated with thousands of hotels to get the very best deals. We call them Secret Deals and they only last for a limited time.
You can get these deals for free by subscribing to our newsletters. You can even choose your favorite destinations to receive personalized deals.
Get started now by entering your email address. We'll instantly send you a link to our Deal Finder!
Don't worry – your email address is safe with us. We'll never share your private information and you can unsubscribe at any time.


text:
Todd Park explains how he has partnered technology with open-data initiatives to tap into the many talented innovators and entrepreneurs across the government. A McKinsey Quarterly Public Sector article.
|Scooped by Peter Hoang
You are the content you publish.
Sign up with Facebook Sign up with Twitter
I don't have a Facebook or a Twitter account
Start a free trial of Scoop.it Business
Your new post is loading...
Your new post is loading...


text:
TITLE: Star Wars Reads Day | NAME: Justin | TKID: 3189 | DATE: 2014-10-16 02:51:03
Star Wars Reads Day was last Saturday, October 11th and was a great success for the MSG-RRG's Joint Ops! Having two events to encourage children to read and to celebrate our love for Star Wars. Darth Vader, a couple of Imperial Stormtroopers, and an out of control Wookiee brought joy to the adults and kids that participated at the B.J. Chain Public Library (Olive Branch, MS). Darth Vader discussed the importance of reading and having a library card. After the introduction, everyone enjoyed crafts, face painting, and photo opportunities with the 501st/Rebel Legion members.
That afternoon, the same 501st/Rebel Legion crew then visited the Booksellers at Laurelwood (Memphis, TN). Adam the Poet was there doing personal poetry. Other activities included games for the kids, photo ops with the 501st/Rebel Legion, and a Star Wars give-away prize pack.
This was year three for the Star Wars Reads Day worldwide celebration. No matter it be a comic, graphic novel, fictional/non-fictional, we challenge you to encourage someone to pickup a book and READ! Oh, and continue to show your love for Star Wars!


text:
Our Newest Items :: Downloads :: Hot Deals NEW :: Message Board :: Why Shop Here? :: Contact Us
Hot Deal
Dice Stacking by Dennis Schleussner - DVD
$24.95 $8.35
Save: 67% off
Reward Points
No points earned yet on current order.
Log in to see how many reward points you have already earned
Nice and safe
I ordered Dan Sperry's Bicycle Crimson Deck. I live in Indonesia. I received the decks and I felt great because they were still in great shape. Nice...
Simply The Best
I really should have taken the time to do this a L-O-N-G time ago. Jeff & Brandi run the BEST online magic shop...period. Their customer service and...


text:
I don't think its a particular currency
as much as countries coming together and saying enough is enough with the Dollar. The BRIC countries will play a large role in this move when they start trading more with their own currencies and stop investing in Dollars. I see this playing out already with the Ukraine cluster-funk. USA and EU one one side and Russia, India, China on the other.
However, if I had to pick, I would say the world will move back to gold and silver again, like it always does, maybe like Hugo Salinas envisions:
"It's not pessimistic, brother, because this is the blues. We are blues people. The blues aren't pessimistic. We're prisoners of hope but we tell the truth and the truth is dark. That's different." ~CW
- Login to post comments


text:
Tel: (608)845-3245
Kids Express Learning Center is a quality full-day and half-day school and nature center for children ages 6 weeks through Kindergarten.
Kids Express Learning Center offers a number of unique opportunities for children to express themselves as they experience the world around them.
Lessons in music and movement, art, Spanish, music, gardening and nature study encourage children to stretch their imaginations, explore and learn.
Teachers with specialized degrees are hired to plan and conduct our Enrichment Programs.
School Overview
|School Type
|Early Childhood / Day Care
|Religious Affiliation
|Grades Offered
|Grades Nursery/Preschool - Kindergarten
|Year Founded
Student Body
|Total Students
|10 students
|Student Body Type
|% Students of Color
State avg.: 26%
|Students by Grade
Academics and Faculty
|Total Classroom Teachers
|40 teachers
|Student : Teacher Ratio
National avg.: 13:1
|Admission Deadline
|None / Rolling
Nearby Schools:
All Schools | High Schools | Elementary Schools | Preschools | Public Schools
Show me:
- School Location Miles Students Grades
MadisonRaymond Road KinderCare
6726 Raymond Road
Madison, WI, 53719
(608)271-0775Daycare / Preschool1 mi | n/a students | Gr. NS-PK
MadisonOur Redeemer Evangelical Lutheran School
1701 Mckenna Boulevard
Madison, WI, 53711
(608)274-2830(Wisconsin Evangelical Lutheran Synod)1.1 mi | 96 students | Gr. PK-8
MadisonMadison Waldorf School
6510 Schroeder Rd
Madison, WI, 53711
(608)270-9005Special Program Emphasis1.6 mi | 76 students | Gr. K-8
MadisonCapitoland Christian School
3651 Maple Grove Dr
Madison, WI, 53719
(608)845-5433(Christian)2.1 mi | 12 students | Gr. PK-1
MadisonSt Maria Goretti Elementary School
5405 Flad Ave
Madison, WI, 53711
(608)271-7551(Roman Catholic)2.3 mi | 422 students | Gr. PK-8
School Reviews
Area Statistics
Recent Articles
Updated October 26, 2014
What do you do when you are dissatisfied with your local public schools? Homeschool your children? Send them to private school? Let's look at your options.
Your religion matters to you. You want your child to attend a school which will combine academics and religious education. Here is an overview of what is available together with some links to denominational web sites.
Add things up and you'll quickly find the answer- math is crucial both in academics and the real world. By following these strategies and following personal training programs, students can uncover their weaknesses and conquer math.
More ArticlesOpinion, Paying For It, High School Issues, Running a Private School, Why Private School