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Anna de Rijk & Tao Okamoto Star in Emporio Armani's Fall 2012 Campaign by Alasdair McLellan
Tokyo at Night – Emporio Armani's fall 2012 campaign enlists top models Anna de Rijk and Tao Okamoto for a Tokyo nighttime outing. Photographed…Read More
Tokyo at Night – Emporio Armani's fall 2012 campaign enlists top models Anna de Rijk and Tao Okamoto for a Tokyo nighttime outing. Photographed…Read More
Innocence in Flames – Belgium label Capara enlists Hannelore Knuts to model its autumn collection of quilted and padded jackets. Designers and sisters Vera…Read More
Ladies in Hats – Taking a first look at Marc Jacobs' fall 2012 advertisements, it appears the American designer is focusing on the collection's…Read More
On Display – Burberry celebrates all things British with its fall 2012 campaign starring actress Gabriella Wilde and musician Roo Panes. The pair was…Read More
Versace First – Versace starts off the fall campaign season with a bang, showcasing a gothic chic series of advertisements starring Dutch new face…Read More
Power of Dress – Ava Smith models the new fall collection from fast fashion retailer H&M. The autumn outing is very fashion forward featuring…Read More
Cool Autumn – Feast your eyes on Mango's fall 2012 catalogue starring Russian beauty Anna Selezneva. The Spanish label's autumn collection is all about…Read More
Club Monaco's Easy Fall – Embracing an easy California style, the fall 2012 collection from Club Monaco offers a wardrobe of autumn staples with…Read More
Simple Autumn Luxe – For fall 2012, German luxury label Strenesse Gabriele Strehle focuses on simple extravagance with a collection of sharp suiting, flirty…Read More


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"Books to the ceiling,
Books to the sky,
My pile of books is a mile high.
How I love them! How I need them!
I'll have a long beard by the time I read them....
All branches of Marin County Free Library will be closed on Thursday, Nov 27 & Friday, Nov 28 for Thanksgiving.
Corte Madera Library will be closed for upgrades Nov 27 - Dec 15, reopening on Dec 16. More details.

subset: commoncrawl


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"At Explore, our teachers genuinely care about us, but there are no passes either. We are expected to achieve."
Nearly 20 years into the charter school movement, less than three percent of our country's students attend a charter school. The demand for high quality schools far outpaces the ability of charter operators to scale their impact through the start of new schools alone.
Critics still contend that charter school students, though they may mirror the demographics of students attending low performing traditional public schools, are somehow different and better able to learn than students who remain in a traditional public school.
Explore will grow from three schools serving 1,000 students to six schools serving 3,000 students by preferencing students who had attended or were zoned to attend schools being phased out by the Department of Education due to poor performance. We will also co-locate with these schools to ensure students in that community have a high quality school option in their neighborhood.
By working with students from low performing schools, we will prove that ALL children can learn in an environment with high expectations, rigorous academics and caring and committed adults.
Read more about our school model and our success.


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Narrow your search
Forget shuffleboard and bring on the skydiving simulator. Crave's Michael Franco stows away on Royal Caribbean's Quantum of the Seas high-tech cruise liner, where robots sail alongside passengers.
CNET breaks out the most important things to know when shopping for a new television.
Although its flash-equipped front camera is eye-catching, its image results aren't as impressive as I'd hoped. Still, the flash will illuminate your face where other phones can't, and the Desire Eye comes with fun software, is well-specced and waterproof too.
Dyson's app-enabled 360 Eye robot vacuum will debut in Japan next spring, with wider availability following later in the year.
Pricing not available
One developer and statistics pro has turned his eye to what makes up the music of Guns N' Roses, proving that when it comes to 80s rock, the hair was high, but the standard deviations were higher.
After reviewing Pixelmator for iPad, I wanted to see how it stacked up against its biggest competitors in the photo-editing category.
The luxury small-appliance company plans to introduce four new product categories over the next four years.
Use a TV or monitor to get a cool halolike ring light effect for your photography.
Microscopic sculptures by artist Jonty Hurwitz are so tiny that they can fit easily inside the eye of a needle, on a human hair -- or on the forehead of an ant.
At the Samsung Developers Conference, home automation company SmartThings offers a glimpse of the ultimate smart home. The firm's open platform enables a fridge that notifies you when the door is left open, a "moisture sensor" that alerts you to leaks, and more.


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What to Listen for in Russian Composers II: Tchaikovsky & Prokofiev at the Kennedy Center
* Additional fees apply.
The last date listed for What to Listen for in Russian Composers II: Tchaikovsky & Prokofiev was Saturday December 12, 2009 / 3:00pm.
Most Popular Music Event Nearby
Hard Rockers Lacuna Coil With Devil You Know: Broken Crown Halo Tour
- Full Price:
- $27.50
- Our Price:
- $20.00
Italian gothic metal band Lacuna Coil comes to The Fillmore Silver Spring to play in support of t...Learn More
Venue Details
It's on the second floor. Don't wear fancy shoes--you'll just take them off before you go in.Shen Wei Dance Arts info • May 27 2013 star this tip starred
Russian composers have made extraordinary contributions to the musical lexicon. Join National Symphony Orchestra cellist Yvonne Caruthers for an exploration of the works of influential Russian composers Pyotr Ilyich Tchaikovsky and Sergei Prokofiev presented during the Kennedy Center's Focus on Russia.
Note: The NSO does not perform in this event.
About the Ticket Supplier: The John F. Kennedy Center for the Performing Arts
The John F. Kennedy Center for the Performing Arts, located on 17 acres overlooking the Potomac River in Washington, D.C., is America's living memorial to President Kennedy as well as the nation's busiest arts facility, presenting more than 2,000 performances each year. The Center is home to seven theaters: the Concert Hall, the Opera House, the Eisenhower Theater, the Family Theater, the Terrace Theater, the Theater Lab, and the Terrace Gallery. In addition, as part of the Kennedy Center's Performing Arts for Everyone outreach program, free performances take place each evening at 6 p.m. on the Millennium Stage. In addition to offering annual series of the National Symphony Orchestra, Washington National Opera, theater, ballet, dance, chamber music, jazz, and performances for young audiences, the Kennedy Center presents festivals celebrating the arts and culture of countries and regions around the world.


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Submitted by Duane Vick on Thu, 12/05/2013 - 22:17. Permalink
I wonder when the buyer first acquired his bitcoins for this car, which retails around $95k. If he has had those bitcoins over a year, he just paid less than $1000 when you consider the initial value of the investment. I would love to know more.
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argotSyllabification: ar·got
Pronunciation: /ˈärɡō, -ɡət /
Definition of argot in English:
The jargon or slang of a particular group or class: teenage argot
More example sentences
- Many words in English have obscure origins, particularly those which may be said to have risen in the world from lowly origins in argot, cant or slang.
- This was not a constructed language, but a secret vocabulary, a cant or argot in the linguist's term, which uses the grammar and syntax of English as well as most of its core vocabulary.
- The dialogue is peppered with the argot and dialect of the Kingston streets, and even with the English soundtrack you simply have to use the subtitles if you are to understand everything they are saying.
mid 19th century (originally denoting the jargon or slang of criminals): from French, of unknown origin.
Definition of argot in:
- British & World English dictionary
- English synonyms
- US English synonyms
- Spanish dictionary
What do you find interesting about this word or phrase?
Get more from Oxford Dictionaries
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Word of the day verbose
Pronunciation: vəːˈbəʊs
using more words than are needed…


text:
Product Code: 29468
Lightweight and easy to work with. High thermal insulation properties and lead-free.View more information
L x W x Th: 2500 x 65 x 6mm. Fixings not supplied.
£51.75 (inc. 20% VAT)
2 Working Days Delivery
Store Collection Unavailable
|Fixings Supplied
|Fixings not supplied
|Manufacturer Guarantee
|10 years
|Pack Size
|Product Depth
|2500 mm
|Product Height
|6 mm
|Product Length
|2500 mm
|Product Thickness
|6 mm
|Product Type
|Architrave / Skirting
|Product Width
|65 mm
|Total Product Weight
|500 kg


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Carrollton Police
Stolen Boots Worth $1 Million Recovered, Suspects Arrested
Boxes and boxes of stolen boots, more than $1 million dollars worth of merchandise, has been found and the people who stole them have been arrested, according to police.
Carrollton Schools Locked Down While Police Search For Suspect
Four Carrollton-Farmers Branch ISD schools have been placed on lockdown as Carrollton Police search for an armed suspect.
Plano Burglar Hitting Up Homes For Plastic
Police in Plano and Carrollton are looking for a man who has broken into several North Texas homes.
Man Charged In Teenager's Death
The Carrollton Police Department has charged a man in the murder of a 16-year-old who reportedly went missing on Thursday.
Police Believe Missing Teenager's Body Found
The Carrollton Police Department is looking for a missing teenager who has not been seen since Thursday afternoon.
Police: Suspects Caused Wreck, Robbed Victims
The summer vacations of two Carrollton high school students began with possibly the most frigtening moment of their lives: They were robbed at gunpoint after two men intentionally hit their car.


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Appt this morning
Find a Conversation
Appt this morning
|Fri, 06-03-2011 - 3:46pm
I'll be 37 weeks tomorrow so I was kind of hopeful going into this appt that the doc would have some good news for me. I have been really uncomfortable and crampy the past couple of days. So you can imagine how disappointed I was when the doc said my cervix was "a little soft"... That's it, no dilation. Just "a little soft".
Also, he asked if I wanted to try a vbac or a repeat c/s. When I said I wanted to try a vbac, he told me that they would not try to induce me at all (pitocin increases the risk of rupture) and that
|Fri, 06-03-2011 - 4:30pm
I'm sorry your appointment was disappointing. I can completely understand your dilemma on the VBAC vs. repeat c-section. I hope the doctor you see next week can help you think about it some more. I honestly don't know what I would do in that situation.


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TIME Topaz Hotel Apartments
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this condo rated in the past?
- Swimming pool
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- Free parking
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TripAdvisor Reviews TIME Topaz Hotel Apartments Dubai
Travel Blogs from Dubai
Decadence in Dubai
... off the elevator, we were greeted by the sounds of a string quartet playing some classic lounge music. We stepped into the colorful room and were escorted to a table next to the bar's gigantic windows that looked out onto the sea and downtown Dubai. Since our anniversary was coming up at midnight, we asked the waiters to watch the clock and bring us champagne right at 12. The waiter graciously complied and we toasted our 1 year anniversary ...
Day 33 Dubai
... mainly jewellery and clothes available but the prices are ridiculously high which is obviously the reason we have seen no one even looking in these shops, let alone buying, as we have passed by over the past day or so.
We then decide to go outside to check out the surrounds of the hotel and the beach. Well it certainly is hotter and more humid than yesterday. Patsy checked a weather App on her iPhone and it tells her ...
Day 2 in Dubai
... back on the shuttle bus to the ship. Otherwise there was a distinct possibility we would have fried, got run over or bankrupted ourselves.
Back on the ship with time on our hands we decided that we needed to do the laundry and went off to do battle in the laundrette.
In the afternoon Jo went to watch the film 'August Osage County'. This was a film with a great cast about a dysfunctional family which ends in disaster for everyone. The ...
Longest Leg of the Fight Done!!
... 8211; this is a massive airport with a train to take you across it. On the four hour stopover I wandered around and there is plenty of glitz and glam and ways to spend your dollars! It is as you can imagine, very clean with kilometres of tiled floors, although you still have to queue for toilets!!
Here is a picture of the escalators and side by side lifts which are enormous.
The SLV adventure finally begins
Well finally I'm on the way to Sri Lanka, currently flying between Dubai and Colombo. Was meant to have left a month ago, but due to visa problems all of us on the March placement couldn't go then. Having a phone call on the Friday when we were due to fly out that Sunday was not good! I didn't get as excited this time, as it took a while to know that the visas were all ok, and I was still dreading something going ...


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Originally written on Fox Sports | Last updated 11/20/14
The Baltimore Orioles are throwing 19-year-old pitching prospect Dylan Bundy into the middle of a pennant race. Baltimore recalled Bundy from Double-A Bowie on Wednesday. The right-hander will provide depth in the bullpen for the Orioles, who played an 18-inning game against the Mariners on Tuesday night and have an upcoming doubleheader against Toronto on Monday. Bundy has not yet played in the majors and will be the first Oriole to debut before his 20th birthday since right-hander Mike Adamson in 1967. Bundy was selected fourth overall in the 2011 draft. He was a combined 9-3 with a 2.08 ERA with three minor league affiliates this season, including 2-0 with a 3.24 ERA in three starts at Bowie.
Original Story: http://msn.foxsports.com/mlb/story/Or...
PLAYERS: Dylan Bundy
TEAMS: Baltimore Orioles
TEAMS: Baltimore Orioles
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text:
Today Swedish Minster of Defence Karin Enström announced that Sweden will buy 60 Gripen E fighter jets from Saab, says a statement issued by Saab.
Saab notes that the decision is within the span previously discussed, both by the Government and the Swedish Armed Forces, in order to meet future defence needs in Sweden until 2042.
This decision once again shows the broad support both from politicians and authorities for Gripen being the back-bone of Swedish air defence for many years to come. It is also proof that Saab has developed a high technology multi role fighter which answers up to defined needs on the market.
FMV has previously said they are expecting a development order for the next generation Gripen in the beginning of 2013. This means that Gripen will be the only next generation fighter which de facto is produced in the western world. This is a proof of strength that shows Saabs high level of innovation and technological competency.
We have held continuous and fruitful discussions with relevant authorities. These talks will now continue until there is a formal order in place.
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Explores how Intel® Virtualization Technology works to enable virtualization and covers common virtualization techniques, types, and implementation.
Explains virtualization fundamentals, business impact, industry factors, model comparisons, and more.
Describes how Intel® technology reduces accidents and improves safety in Rio de Janeiro, Brazil.
Demos how virtualization and manageability improve network efficiency; Portuguese subtitles.
Demo runs two OSs with Intel® architecture and virtualization for wireless medical use case.


text: Ben Shapiro Follow Share This: Print Latest News 5 Reasons America Is Losing The New Cold War America is in a new Cold War. It may be undeclared, but then again, so was the Cold War itself. Feb 27, 2014 11:00 AM PT 7 Myths About Arizona's Religious Freedom Law This week, controversy has broken out over Arizona's law protecting the right of religious businessowners to reject service to particular customers. The law came hard on the heels of a series of outrageous court decisions finding that private businesses could be forced, in violation of their religion, to serve events such as same-sex weddings. Feb 26, 2014 3:42 PM PT Obama's Historic Defense Cuts Spell Disaster On Monday, Secretary of Defense Chuck Hagel announced massive cuts to the size of the armed services, slashing the army to its pre-World War II size. In 2011, the army had some 566,000 soldiers; Hagel wants it cut to somewhere between 440,000 and 450,000 troops by 2019. If Congress does not add additional funding, Hagel threatens to slash that number to 420,000 by 2019. Feb 25, 2014 12:05 PM PT Eugenicists Rejoice: More Black Babies Aborted Than Born in NYC On Friday, the New York City Department of Health and Mental Hygiene Office of Vital Statistics released a report titled "Summary of Vital Statistics 2012 The City of New York, Pregnancy Outcomes." As expected, the report showed an exceedingly high number of abortions and an exceedingly low number of births. Feb 21, 2014 1:26 PM PT Obama Crackdown on Press Freedom Escalates Last week, Reporters Without Borders dropped America in the World Press Freedom Index 2014 from 33rd to 46th. James Risen of The New York Times rightly explained, "I think 2013 will go down in history as the worst year for press freedom in the United States' modern history." And he's right. The violation of press freedoms has been egregious under this administration, even as the press fetes President Obama as an honest and effective commander-in-chief. Feb 20, 2014 8:43 AM PT US Votes Absent as Ukraine Burns On Wednesday, the White House announced that it would be taking a muscular new role in Ukraine: by deferring to the Russians. Again. Feb 19, 2014 12:22 PM PT Presidents Day Is Idiotic George Washington was born on February 22, 1732. Abraham Lincoln was born February 12, 1809. Neither was born on February 17. Yet today, many of us are staying home from work because of the federally declared Presidents Day, Feb 17, 2014 9:47 AM PT From Jerusalem to London to Lubbock: The Global War on Conservatism It is difficult to see how the future of Texas looks like the present of London; it is difficult to see how the future of London looks like the present of Jerusalem. Nonetheless, in the battle for Western civilization, all three locations exist along the same timeline, the same continuum. Feb 17, 2014 8:33 AM PT Why the Sochi Olympics Are an Epic Fail The Winter Olympics have not lived up to the hype. NBC's primetime numbers are down dramatically from the Olympics coverage four years ago. That was down 29% from the first Wednesday broadcast in Vancouver. The average of 20.8 million viewers represented a drop of more than 8 million viewers. Feb 15, 2014 5:29 PM PT 11 Horrible Ideas For Valentine's Day Gifts It's Valentine's Day – and that means it's time to get a gift for your special someone. What is she looking for? Traditional flowers and chocolates are passé; a nice dinner seems hackneyed. Feb 14, 2014 8:56 AM PT Lawless: Obamacare and the Imperial Government On Monday, the Obama administration announced that it would be delaying one of the key components of Obamacare yet again. This time, the Treasury Department stated that mid-sized employers – businesses with between 50 and 99 employees – would be able to avoid paying for employee insurance without a fine until 2016. Feb 11, 2014 10:52 AM PT Is Michael Sam's Coming Out a Milestone, or a Media Set-Up? Last year, Missouri defensive lineman Michael Sam announced that he was gay to his teammates. In an interview with The New York Times on Sunday, he publicly announced his sexual orientation to the general public. Feb 10, 2014 7:45 AM PT Hillary's Top 7 Elitist Moments On Monday, former Secretary of State and First Lady Hillary Clinton spoke at the National Automobile Dealers Association in New Orleans – where she quickly revealed that she has not driven a car for the past 18 years. At a convention of auto dealers. Jan 27, 2014 6:46 PM PT Obama to Push Net Tax Hike on Businesses in SOTU According to Americans for Tax Reform, President Obama will push a tax hike on American businesses in his State of the Union Address on Tuesday. Jan 27, 2014 10:42 AM PT 'Chip in $10 to Protect Obamacare': Michelle O Fundraises for Dems Before SOTU On Monday, First Lady Michelle Obama used the upcoming State of the Union address to fundraise for the Democratic Party. She wrote a letter to the group's mailing list requesting that followers "chip in $10 or more and help protect Obamacare." Jan 27, 2014 8:55 AM PT Previous 6 7 8 9 10 11 12 13 14 15 16 Next


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OKOLONA – The Magnolia Festival will bloom in Okolona this weekend with three days of food, fun and music. For the third year in a row the city and local businesses have co-sponsored the summertime event aimed at bringing people to Okolona and showing off the downtown area. "It's all about Okolona and it's always […]
Tag Archives | Magnolia Festival
Magnolia Festival blooms in Okolona
By Floyd Ingram | 12:55 PM | July 25, 2013 | Business, Living, News
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Skipper released the new support tool for all technicians serving acoustic products. The Skipper ETT985 is a combined echo sounder simulator, transducer tester and NMEA tester, in a single handheld unit.
This tool allows the technician to test both the acoustical functions of the Echo Sounder and Transducers. The ETT985 has a built-in rechargeable battery.
The simulator will measure the transmitted pulse and replying with either the same pulse or a user defined pulse. In conjunction with the systems data bulletin an integrity test of the Echo Sounder unit can be performed in minutes.
Transducer tester:
This is a tester that measures the characteristics of the transducer, showing the resonance and electrical characteristics of the transducer. Using preprogrammed limits, the user can select a pre-programmed transducer and check with the factory values. A simple pass/fail is given. The tester works for any transducer (directly to transducer, not through circuitry).
NMEA tester:
The NMEA tester can monitor NMEA lines, loop back signals from devices and send standard formats for GPS, Gyro, Echo Sounders, Speed Logs etc.
It can also be used as a NMEA RS232 converter or directly to USB with included converter.
A new Skipper service software is also now available at no cost, giving tools for diagnostics for EML224 sensor, and the ETT985, as well as providing a terminal emulator.
With the optional software activated, the software changes the tester to a lab tool by increasing the functionality of the tester.
Using a serial port, the tester can be connected to the PC based software enabling the user to access extra parameters of the system.
The simulator can directly be controlled and be made to also generate fish signals for fish-finder Echo Sounders. It also allows a serial input function to change the depth and settings of the unit (ideal for bridge simulators).
The transducer tester becomes a full (un-calibrated) impedance analyzer showing the full plot of frequency vs. impedance, subsistence, conductance, and phase as well as detecting the resonance, anti-resonance and calculating the bandwidth of the Transducer. In addition the limits of any Transducer can be programmed such that the pass/fail integrity test of any compatible Transducer can be checked with the tester alone in the field.
The NMEA tester can be programmed with your own formats and saved in the tester for later use.
State-controlled Exportadora de Sal SA de CV of Mexico ("ESSA"), one of the world's largest salt exporters with a 10-million-ton annual production, has strengthened
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Classification society DNV GL recognised that E.R. Schiffahrt has retrofitted seven ultra large container vessels to meet the highest energy efficiency standards
More so than many other fields of business, the maritime industry is focused on cost, which in turn gives the appearance of being conservative towards technology.
L-3 SAM Electronics has announced that, via its L-3 Marine Systems Korea subsidiary, it has been awarded a contract to provide its NACOS Platinum navigation, automation and control system,
Reach Subsea has secured a deal worth up to $10.3 million with Technip to provide remote-operated vehicle services on a newbuild subsea construction vessel to be supplied by Eidesvik Offshore.


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REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology.
ABSTRACT A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior, but when this synchronization is disturbed, chronic diseases such as metabolic syndrome and depression may develop. Three new studies show that nuclear receptors of the Rev-Erb family impact the circadian oscillator and its metabolic output and this can be modified with specific agonists. Hence, resynchronization of metabolic pathways by manipulation of the circadian oscillator using REV-ERB-specific agonists may represent a feasible therapeutic concept to target diseases rooted in a misaligned circadian system.
- SourceAvailable from: Anton M Jetten
Article: Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity.[Show abstract] [Hide abstract]
ABSTRACT: The hepatic circadian clock plays a key role in the daily regulation of glucose metabolism, but the precise molecular mechanisms that coordinate these two biological processes are not fully understood. In this study, we identify a novel connection between the regulation of RORγ by the clock machinery and the diurnal regulation of glucose metabolic networks. We demonstrate that particularly at daytime, mice deficient in RORγ exhibit improved insulin sensitivity and glucose tolerance due to reduced hepatic gluconeogenesis. This is associated with a reduced peak expression of several glucose metabolic genes critical in the control of gluconeogenesis and glycolysis. Genome-wide cistromic profiling, promoter and mutation analysis support the concept that RORγ regulates the transcription of several glucose metabolic genes directly by binding ROREs in their promoter regulatory region. Similar observations were made in liver-specific RORγ-deficient mice suggesting that the changes in glucose homeostasis were directly related to the loss of hepatic RORγ expression. Altogether, our study shows that RORγ regulates several glucose metabolic genes downstream of the hepatic clock and identifies a novel metabolic function for RORγ in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity. The inhibition of the activation of several metabolic gene promoters by an RORγ antagonist suggests that antagonists may provide a novel strategy in the management of metabolic diseases, including type 2 diabetes.PLoS Genetics 05/2014; 10(5):e1004331. · 8.52 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Abstract Circadian rhythm has been the object of much attention. This review addresses the aspects of cell signaling, receptors, therapy and electrical effects in a multifaceted fashion. The pineal gland, which produces the important hormones melatonin and serotonin, exerts a prominent influence, in addition to the supraschiasmatic nucleus. Many aspects involve free radicals which have played a widespread role in biochemistry.Journal of Receptor and Signal Transduction Research 08/2013; · 1.63 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Colorectal cancer is the most prevalent among digestive system cancers. Carcinogenesis relies on disrupted control of cellular processes, such as metabolism, proliferation, DNA damage recognition and repair, and apoptosis. Cell, tissue, organ and body physiology is characterized by periodic fluctuations driven by biological clocks operating through the clock gene machinery. Dysfunction of molecular clockworks and cellular oscillators is involved in tumorigenesis, and altered expression of clock genes has been found in cancer patients. Epidemiological studies have shown that circadian disruption, that is, alteration of bodily temporal organization, is a cancer risk factor, and an increased incidence of colorectal neoplastic disease is reported in shift workers. In this review we describe the involvement of the circadian clock circuitry in colorectal carcinogenesis and the therapeutic strategies addressing temporal deregulation in colorectal cancer.World Journal of Gastroenterology 04/2014; 20(15):4197-4207. · 2.55 Impact Factor
Page 1
REV-ERB-erating nuclear receptor functions in circadian
metabolism and physiology
Jürgen A Ripperger1, Urs Albrecht1
1Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musée 5, 1700 Fribourg, Switzerland
Cell Research (2012) 22:1319-1321. doi:10.1038/cr.2012.81; published online 22 May 2012
Cell Research (2012) 22:1319-1321.
© 2012 IBCB, SIBS, CAS All rights reserved 1001-0602/12 $ 32.00
Correspondence: Urs Albrecht
E-mail: firstname.lastname@example.com
A hallmark of the mammalian
circadian timing system is synchro-
nization of physiology and behavior,
but when this synchronization is
disturbed, chronic diseases such as
metabolic syndrome and depression
may develop. Three new studies
show that nuclear receptors of the
Rev-Erb family impact the circadian
oscillator and its metabolic output
and this can be modified with specific
agonists. Hence, resynchronization of
metabolic pathways by manipulation
of the circadian oscillator using REV-
ERB-specific agonists may represent
a feasible therapeutic concept to
target diseases rooted in a misaligned
circadian system.
The circadian clock simulates the
external light:dark cycle in essentially
all body cells [1]. The coarse separation
into activity and rest phase optimally
synchronizes anabolic and catabolic
pathways not only in individual cells,
but also in the surrounding tissue and
even the entire organism. A paired
neuronal structure in the hypothalamus,
the so-called Suprachiasmatic nuclei
(SCN), keep the organism in resonance
with the environment. This master
clock converts the external light:dark
information into hormonal and electro-
physiological signals synchronizing all
other cell-autonomous circadian clocks
in the periphery. Like this stable phase-
relationships between all of the organs
are established. By definition ('circa
diem' translates to 'about a day') circa-
dian clocks provide a period length of
about a day. However, this slight daily
imprecision is not a problem, because
sophisticated regulatory mechanisms,
e.g., based on light input or food uptake,
provide sufficient flexibility to the clock
mechanism to readjust every day to the
Many diseases may be related to
disturbances of specific metabolic or
physiological pathways. For instance,
in metabolic syndrome the balance
between the energy-generating glucose
metabolism and the energy-storing
lipid metabolism is disturbed [2]. On
the other hand, de-synchronization of
hormone secretion and clearance aggra-
vates neuropsychiatric disorders such
as seasonal affected disorder (SAD),
depression or bipolar disorder [3]. The
finding that strict daily routines of sleep-
ing and eating times, or light therapy can
ameliorate to a certain degree these neu-
ropsychiatric disorders [4] highlights
the importance of the circadian system
to maintain the normal state. Hence,
drugs that readjust the synchronizing
properties of the circadian clock would
be beneficial. For example, lithium
is used to treat bipolar disorder and
impacts various molecular pathways
including components of the circadian
clock [5].
At the heart of the circadian clock
is a molecular oscillator based on tran-
scriptional and post-translational feed-
back loops [1]. Briefly, a heterodimer
composed of BMAL and CLOCK (or
NPAS2 in the brain) activates transcrip-
tion of two sets of repressors (blue line;
Figure 1). The first set (i.e., Per and Cry)
feeds back via E-box motifs (black box-
es) after a certain delay on its own syn-
thesis (pink lines) and these consecutive
cycles of activation and repression cre-
ate transcriptional rhythms of about 24
h. The second set was thought to solely
regulate rhythmic accumulation of the
Bmal1, Clock and Npas2 genes (red
lines) via RORE motifs (white boxes).
This second, stabilizing feedback loop
relies on alternate repression by REV-
ERBα and activation by RORα (not
shown). Input factors such as light (via
induction of Per genes) or food uptake
(via metabolism) affect the phase of the
system (grey lines). Circadian output
target genes regulating for example key
enzymes of metabolic pathways can be
either directly coupled to the molecu-
lar oscillator via E-box and/or RORE
motifs, or via rhythmically expressed
transcription factors as intermediates.
Among the different families of tran-
scriptional regulators, members of the
family of nuclear receptors link the cir-
cadian timing system with metabolism
[6, 7]. In this fashion, tissue-specific
intertwined networks of gene expres-
Page 2
www.cell-research.com | Vol 22 No 9 | September 2012
sion are generated. This is the base for
the temporal synchronization of the
multiple metabolic pathways.
Experiments by Bugge et al. [8] and
Cho et al. [9] combining chromatin-im-
munoprecipitation (ChIP)-sequencing
with powerful knockout animal systems
shed new light on the function of both
nuclear receptors of the Rev-Erb fam-
ily within the circadian transcriptional
network. Surprisingly, many new RORE
motifs were identified in core circadian
oscillator genes (Figure 1) and tran-
scriptome analysis of Rev-Erb-deficient
mice revealed that the expression of
these genes was actually affected.
Hence, the REV-ERB nuclear receptors
have a more prominent function within
the circadian oscillator than previously
thought, which became apparent only
after the inactivation of both Rev-Εrbα
and β isoforms. Mice lacking both
isoforms displayed a shorter circadian
rhythm, which resembles mice deficient
in other circadian oscillator components.
Interestingly, the lipid metabolism, and
to some extent cholesterol and bile acid
production, were severely affected, with
the liver displaying a typical lipid over-
storage phenotype, i.e., hepatosteatosis.
As conclusion, the balance of lipid and
glucose metabolism is disturbed in these
animals. Considering the fact that these
nuclear receptors impact circadian os-
cillator and output functions and that at
least REV-ERBα readjusts its phase in
response to external influences on the
circadian timing system [10], targeted
activation of these factors using agonists
may improve coordination of metabolic
Solt et al. [11] now identified a new
class of agonists for nuclear receptors of
the Rev-Erb family. In vitro, they bound
specifically and with high affinity, and
suppressed circadian reporter genes in
cultured cells or SCN explants. In vivo,
administration of these drugs at the
peak of REV-ERB activity suppressed
circadian locomotor activity and REV-
ERB target gene expression. Hence,
these drugs overcame the blood-brain
barrier to exert their function even in the
SCN. Surprisingly, the activity of these
drugs was stronger in the absence of
light but it was not determined whether
this was due to a faster clearance of
these drugs from the circulation in the
presence of light, or due to competi-
tion of their action with the light input
pathway because they mimic input
function (Figure 1). In addition, these
drugs increased fatty acid and glucose
oxidation, while reducing the amount
of lipogenesis and bile acid synthesis.
As a consequence, treated mice became
leaner and were more resistant to the
detrimental effects of high-fat diet. In-
terestingly, these drugs reduced weight
gain in obese mice that lack leptin,
indicating that the newly discovered
REV-ERB agonists affect at least par-
tially metabolic pathways downstream
or independent of leptin. Taken together,
specific agonists for nuclear receptors of
the REV-ERB family hold the potential
to resynchronize metabolic pathways in
living organisms. Potential applications
concern metabolic syndrome, Jet-lag
(i.e., desynchronization of SCN and
peripheral clocks), and possibly neu-
ropsychiatric disorders. Future studies
will have to address the effect of these
drugs on the central nervous system,
especially whether and how sleep- and
mood-related behaviors are affected.
It will be challenging and exciting
to translate basic research performed
in mice to the clinic for treatment of
1 Huang W, Ramsey KM, Marcheva
B, Bass J. Circadian rhythms, sleep,
and metabolism. J Clin Invest 2011;
Figure 1 Impact of nuclear receptors of the Rev-Erb family on the circadian os-
cillator and their effect on metabolism. Blue: positive factors; red, pink: two sets
of negative factors. The core clock mechanism governs rhythmic expression of
output genes. The phase of the system is every day readjusted by light or food
uptake (input; grey arrows). Specific agonists for nuclear receptors of the Rev-
Erb family mimic these adjusting properties and may impact on metabolic func-
tions. For details, see text.
Page 3
www.cell-research.com | Cell Research
2 Levinson RS. Metabolic syndrome.
Nat Med 2011; 17(Suppl):4-7.
3 Ciarleglio CM, Resuehr HE, McMahon
DG. Interactions of the serotonin and
circadian systems: nature and nurture
in rhythms and blues. Neuroscience
2011; 197:8-16.
4 Hlastala SA, Frank E. Adapting inter-
personal and social rhythm therapy to
the developmental needs of adolescents
with bipolar disorder. Dev Psycho-
pathol 2006; 18:1267-1288.
5. Li J, Lu WQ, Beesley S, Loudon AS,
Meng QJ. Lithium impacts on the am-
plitude and period of the molecular
circadian clockwork. PLoS One 2012;
6 Schmutz I, Ripperger JA, Baeriswyl-
Aebischer S, Albrecht U. The mamma-
lian clock component PERIOD2 coor-
dinates circadian output by interaction
with nuclear receptors. Genes Dev
2010; 24:345-357.
7 Lamia KA, Papp SJ, Yu RT, et al. Cryp-
tochromes mediate rhythmic repression
of the glucocorticoid receptor. Nature
2011; 480:552-556.
8 Bugge A, Feng D, Everett LJ, et al.
Rev-erbα and Rev-erbβ coordinately
protect the circadian clock and normal
metabolic function. Genes Dev 2012;
9 Cho H, Zhao X, Hatori M, et al. Regu-
lation of circadian behaviour and me-
tabolism by REV-ERB-α and REV-
ERB-β. Nature 2012; 485:123-127.
10 Stratmann M, Stadler F, Tamanini F,
van der Horst GT, Ripperger JA. Flexi-
ble phase adjustment of circadian albu-
min D site-binding protein (DBP) gene
expression by CRYPTOCHROME1.
Genes Dev 2010; 24:1317-1328.
11 Solt LA, Wang Y, Banerjee S, et al.
Regulation of circadian behaviour and
metabolism by synthetic REV-ERB
agonists. Nature 2012; 485:62-68.


text:
Tel: (734)241-3923
St. Michael the Archangel School is a Catholic community whose mission is to provide spiritual formation and a complete educational program in a Christian environment.
Students plan, participate in and lead a variety of spiritual growth activities.
Academics are strong, with 90% or better of the 8th Grade passing all MEAP (state assessed) tests.
St. Michael's is accredited by the Michigan Non-Public Schools Accrediting Association.
Most recently, we have been invited by the MNSAA to participate in its School of Distinction Program.
We have submitted our candidacy for review.
School Overview
|School Membership(s)School Assoc.
|National Catholic Educational Association (NCEA)
State or regional independent school association
|Religious Affiliation
|Roman Catholic
|Grades Offered
|Grades Prekindergarten - 8
Student Body
|Total Students
|174 students
|Student Body Type
|Students by Grade
Academics and Faculty
|Total Classroom Teachers
|10 teachers
|Student : Teacher Ratio
National avg.: 13:1
|% Faculty w/Advanced Degree
|Classroom Dress Code
(Our uniform policy is posted on our website)
Finances and Admission
|Admission Deadline
|None / Rolling
|Tuition Notes
|We offer a family discount and have need-based financial aid available. Every family receives at least $150 in aid.
|Total Sports Offered
|6 sports
|Baseball, Basketball, Football, Soccer, Softball, VolleyballBaseball, Basketball,
Football, Soccer,
Softball, Volleyball,
|Total ExtracurricularsTotal Extra-curric.
|4 extracurriculars
|Afterschool Title I Tutoring Program, CYO Sports Program for Grades 5-8, Junior Band Program at SMCC H.S., Parish-based Boy Scouts of America Program Afterschool Title I Tutoring Program,
CYO Sports Program for Grades 5-8,
Junior Band Program at SMCC H.S.,
Parish-based Boy Scouts of America Program,
School Notes:
- St. Michael's is a parish-based and supported Catholic school.
- We have a pre-school classroom and an extended school program.
- Currently, Title I tutoring is offered in an afterschool program Mon-Thurs for qualifying students.
- We offer an academic Jumpstart program for several weeks at the end of summer for any interested students.
- We are committed to helping families in need of financial assistance and offer a daily hot lunch program supported by the federal Free and Reduced Hot Lunch Program.
Nearby Schools:
All Schools | High Schools | Elementary Schools | Preschools | Public Schools
Show me:
- School Location Miles Students Grades
MonroeTrinity Lutheran School
315 Scott St
Monroe, MI, 48161
(734)241-1160(Lutheran Church -- Missouri Synod)1.2 mi | 136 students | Gr. PK-8
MonroeSt Mary School
151 N Monroe St
Monroe, MI, 48162
(734)241-3377(Roman Catholic)1.2 mi | 271 students | Gr. PK-8
MonroeSt. Mary Catholic Central High School
108 W Elm Ave
Monroe, MI, 48162
(734)241-7622(Roman Catholic)1.3 mi | 427 students | Gr. 9-12
MonroeSt John Elementary School
521 S Monroe St
Monroe, MI, 48161
(734)241-1670(Roman Catholic)1.4 mi | 209 students | Gr. PK-8
MonroeZion Lutheran School
186 Cole Rd
Monroe, MI, 48162
(734)242-1378(Wisconsin Evangelical Lutheran Synod)1.6 mi | 53 students | Gr. PK-8
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Updated October 26, 2014
What do you do when you are dissatisfied with your local public schools? Homeschool your children? Send them to private school? Let's look at your options.
Your religion matters to you. You want your child to attend a school which will combine academics and religious education. Here is an overview of what is available together with some links to denominational web sites.
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text:
- Address: Carrer de Sant Pere Mes Alt, 6
- Admission: Check website for event prices
Palau de la Música Catalana
A striking Modernista redbrick façade marks the entrance to the Palau de la Música Catalana, characterized by its intricate mosaics, colorful pillars and ornamental balcony. The interiors are even more impressive, with the lavishly decorated auditorium centered around an eye-catching stained glass skylight. Declared a UNESCO World Heritage Site in 1997, the concert hall features décor by some of the era's most prominent Catalan architects – a sumptuous museum including ceramic mosaics and relief busts by Eusebi Arnau, a stone arch by Pau Gargallo, vibrant mosaics by Lluís Bru and stained glasswork by Antoni Rigalt.
Although the concert hall is not renowned for its acoustics, the Palau provides a suitably glittering backdrop to performances, making attending a concert at the venue a rich audio-visual experience. The 2000-seat auditorium regularly sells out, so book tickets well in advance or opt for a guided tour of the auditorium to fully appreciate the architectural marvel.
Tours & Tickets
Barcelona Half-Day Bike Tour
There's no better way to see the sights and learn the history of Barcelona than by joining a bike tour! You get to have fun and socialize, have some exercise ... Read more
Barcelona, Spain
Duration: 4 hours (approx.)
'The Shadow of the Wind' Walking Book Tour in Barcelona
Discover central Barcelona in a unique way with this guided walking tour of locations in 'The Shadow of the Wind,' a bestselling novel by Spanish writer Carlos ... Read more
Barcelona, Spain
Duration: 2 hours 30 minutes (approx.)
Barcelona Modernism and Gaudi Walking Tour
Join a Barcelona walking tour of Quadrat d'Or, or Golden Square, in the Eixample district. This is an exceptional area that became the focus of 'modernist' ... Read more
Barcelona, Spain
Duration: 2 hours (approx.)
Flamenco Performance at Teatre Poliorama or Palau de la Música Catalana
See the acclaimed 'Gran Gala Flamenco' show at Barcelona's Teatre Poliorama or Palau de la Música Catalana! Featuring accomplished Catalan flamenco ... Read more
Barcelona, Spain
Duration: 90 minutes (approx.)
Opera and Flamenco Performance in Barcelona at Teatre Poliorama or Palau de la Música Catalana
Enjoy a mix of flamenco and soul-stirring opera music with a ticket to the 'Opera y Flamenco' show at either Teatre Poliorama or Palau de la Música ... Read more
Barcelona, Spain
Duration: 90 minutes (approx.)


text:
Photo courtesy of Diane Lanning
SAN FRANCISCO — For die-hard BYU fans here, the Dec. 27 Fight Hunger Bowl was far more than a football game between the Cougars and the University of Washington.
For one, the holiday-season bowl at San Francisco's AT&T Park offered the team and its local followers an opportunity to participate in a faith-promoting devotional on the eve of the game.
On Dec. 26, about 1,000 people squeezed into the Temple Hill Auditorium near the Oakland California Temple for the team devotional. The hour-long event included remarks from Coach Bronco Mendenhall, his wife, Holly Mendenhall, and senior wide receiver Skyler Ridley.
Several BYU players and their wives also performed a musical number. After the devotional, the coaches and players enjoyed mingling with fans and family members and posed for numerous photos.
"The devotional really deepened my appreciation for the team and the school and church they represent," said Tim Bean, chairman of the East Bay chapter of the BYU Alumni Association.
The pregame event — which has become a football tradition over the past decade — "helped to humanize the team and the coaches," said Brother Bean. "You realize these are guys with wives and families who are trying to better themselves and the football program."
Coach Mendenhall focused his message on faith, spiritual guidance and finding and following priorities.
Staging the devotional wasn't easy. The local alumni association had just two weeks to organize the event after BYU was invited to participate in the bowl game. Under the presiding direction of the Oakland California Stake, assignments were made and invitations extended to all Bay Area members and their friends and neighbors.
Brother Bean said many who attended the devotional were not Latter-day Saints. All were made to feel welcome, he added.
Local Cougar fans also answered the titular challenge issued by the bowl game and did their part to help fight hunger.
Fans and alumni from BYU and the University of Washington staged a competition to see which fan base could collect the most food for local families in need. Food and cash donations made to San Francisco-area food banks accounted for more than 30,000 meals.
The fan fun continued on game day. The BYU Alumni Association sponsored a tailgate party and pep rally — replete with appearances from the BYU band and cheerleaders — for some 650 Cougar fans prior to the game.
Almost 35,000 people attended the game — "and more than half the stadium was BYU fans," said Brother Bean.
The Cougar football team walked onto the gridiron hoping to extend their school-record four-game bowl-winning streak. In the end, that record was undone by missed scoring opportunities and trouble on special teams.
Washington would raise the Fight Hunger Bowl trophy after claiming a 31-16 victory.
BYU outgained the Huskies in total offense by more than 150 yards but struggled to finish with touchdowns.
"We weren't able to put it in the end zone," said Coach Mendenhall.
The Cougars finished the season with an 8-5 record that included memorable wins over Texas, Boise State and Utah State.
Now the coaches and team turn their attention to the 2014 campaign. They will lose graduating team leaders Kyle Van Noy — an All-American linebacker — and Cody Hoffman, who set several school receiving records.
Still, the program's proverbial cupboard is not bare. Star quarterback Taysom Hill and running back Jamall Williams will both return for their junior seasons.
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text:
Key things you need to know aboutDr. Byrne:
Dr. Byrne's Experience
Research training, expertise and qualifications
Dr. Byrne's Specialties
- Vascular & Interventional Radiology
- View 1 specialty
Procedures Dr. Byrne Performs
- Aortic Repair, Open or Repair of Arterial Aneurysm, Open
- Cardiac Catheterization (incl. Coronary Angiography)
- See all 14 procedures
Conditions Dr. Byrne Treats
- Aortic Aneurysm
- Aortic Dissection
- See all 25 conditions
More About Dr. Byrne's Background
Hospital Quality
The right hospital is as important as the right doctor
- Glens Falls Hospital
- 100 Parks Street
- Glens Falls, NY 12801
- Saratoga Hospital
- 211 Church Street
- Saratoga Springs, NY 12866
9 Facts About Hospital Quality
Patients' risk of dying during a hospital stay for heart bypass surgery could be 85.2% lower, on average, at a hospital rated 5 stars compared to a hospital rated 1 star for that procedure. Choosing the right hospital is critical to your health. View Slideshow
Patient Satisfaction
Patients' feedback on their experience with Dr. Byrne
Likelihood of recommending Dr. Byrne to family and friends is 5 out of 5 5 1 3
See More Survey Results
8 Facts About Patient Satisfaction Surveys
Patient satisfaction surveys provide a standardized way of reporting about healthcare experiences. But there can be more than meets the eye when reviewing scores. Here's what you should know
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Accepting new patients?
- Yes
- 43 New Scotland Ave
- Albany, NY 12208
- Vascular Group PLLC
- Vascular Group PLLC
- 102 Park St
- Glens Falls, NY 12801
7 Tips to Prepare for Your Appointment
The key to a successful appointment is communication. To get the most out of your visit, prepare ahead of time so you can lead the conversation with your doctor. These 7 tips will get you ready
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Home & Decor
Showing results 1 – 7 of 7.
Hand Tufted
SousVide 9 Liter Water Oven, VS3000 Vacuum Sealer, Easy SousVide Cookbook, 2 Small Boxes of Cooking Pouches, 1 Large Box Cooking Pouches, Baking Rack, Dessert Recipe Booklet
System is both front loading and free standing and can sit flush against a wall, made from heavy gauge steel and other strength-tested materials, up to 450 can storage capacity, 56 Food Label Magnets included, weight: 85 lbs, dimensions: 36.5"W x 24.5"L x 72"H.
12 Cup, 2 Decanters, black, 3.9 Gallons, 100 Cups Per Hour.
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Includes 25 Popcorn Bags, Measuring cups, Popcorn scoop. Choose between black or red, makes roughly 3 gallons of popcorn per batch and 16" wheels


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Indian teens use mobile phones to thwart taboos, tradition and, of course, their parents.
Parents who have caught on are blaming text messaging for promoting Western-style teenage romance and dating behavior in this still-conservative country, where parental controls are typically not relinquished until the children grow up and marry, and sometimes even longer.
With 400 million mobile phone users currently, and 10 million more added each month, India is the world's fastest growing cell phone market. India's youth are helping to fuel the increase.
Cell phones offer a private, inexpensive means of networking for youth, said Raghunath Mandava, a chief marketing officer at the New Delhi-based Bharti Airtel, India's largest cell phone service provider.
The texting phenomenon cuts across economic lines in a country where only a small fraction of the population has internet access, he said.
At rates as low as 0.10 rupee (a fraction of a cent) for a text message, down from 10 times that rate last year, young India is texting furiously. According to Bharti, which currently has 100 million users, 40 percent of its users send the bulk of text messages — more than 3 billion every month.
Texting, Mandava said, is big among Indians "who are in situations where rightful privacy is also deprived," as they live in crowded cities and cramped spaces.
Mobile phones are slowly seeping into everyday life in India. Billboards describe how easy it is to buy multiplex movie tickets by SMS or text messaging. Radio stations ask listeners to text in traffic hotspots. Banks urge Indians to use their cell phones to complete financial transactions.
So, it is only natural that teenagers like Jaykumar and Rajesh have quickly taken to cell phone romance and find themselves texting both their male and female friends in every spare moment.
While the debate in the West centers on whether technology is killing romance, in India technology seems to be encouraging romance, albeit furtively.
The scrolling bars on many satellite music channels airing Bollywood songs pulsate with teenage text missives. "R U Ok? I miss U" says one. "Last evening was un4gettable" says the next. A particularly telling one asks, "Shall we meet 2moro, same time? Home Alone."
More GlobalPost dispatches on India:
From the network that brought you MTV: Child marriage


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Jury Awards over $170,000 in pregnant teacher firing case
06/03/2013 // West Palm Beach , Florida, US // JusticeNewsFlash // Justice News Flash // (press release)
Ohio – A jury has awarded a Catholic school teacher over $170,000 in her discrimination case. As reported by the Associated Press (AP), the federal jury found in favor of Christa Dias who alleged the Roman Catholic Archdiocese of Cincinnati discriminated against her in firing her due to her becoming pregnant through artificial insemination.
Dias was accused by her employer of violating church doctrine and breaking her contract. The discrimination case the second of its kind in the past couple of years to be filed over an unmarried teacher being fired according to the AP.
Dias also sued two schools; however, jurors did not find them liable in the case. The jury awarded $71,000 for compensatory damages including back pay, and $100,000 in punitive damages.
Dias is quoted as stating to the AP in a telephone interview of the case, "It was never about the money… They should have followed the law and they didn't."
Justice News Flash delivers the latest in Ohio legal news.
Media Information:
Address: 215 South Olive Suite 300 W. Palm Beach FL 33401
Phone: 866-598-1315
Url: http://justicenews.visionsmartnews.com/jury-awards-over-170000-in-pregnant-teacher-firing-case_9436.html
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- Bill Cosby rape accuser questions why no one listened before
- Texas woman pleads guilty after murder and kidnapping


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Paula Creamers' Pre-Tournament Interview at the 2013 Kia Classic
Topics: Interviews, Creamer, Paula, Kia Classic
Rolex Rankings No. 1 Jiyai Shin fired a final-round five-under 67 to win the Mizuno Classic Sunday. The victory was Shin's second at the Kintetsu Kashikojima Country Club and eighth on the LPGA Tour. Shin carded five birdies and no bogeys in the final round to take home the first-place prize of $180,000.


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News Details
Vettel: "We Weren't Quick Enough Today"
For the second time in three races, four-time World Formula 1 Drivers Champion Sebastian Vettel failed to make it into the final part of qualifying. The German Red Bull driver will start from eleventh having initially qualified twelfth, gaining a place due to the penalty that his team-mate Daniel Ricciardo carried over from the previous race in Malaysia. Ricciardo had qualified third, but will start from thirteenth. "We weren't quick enough today," admitted a disgruntled Vettel. "I was pretty happy yesterday, but I think this morning didn't help us when I spun off and did some damage to the car. It's hard to say how big the impact of that was, as once you start qualifying...
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queXS 1.10.4
Features at a glance
Key features include the ability to easily create appointments with automatic time zone calculations, set quotas with auto-prioritisation, collect data using the powerful LimeSurvey survey software tool, generate PDF questionnaires using queXML, import of sample information from CSV files, and the ability to handle multiple phone numbers.
Additionally, the application can store case outcomes in the AAPOR Standard Definition format, exports LimeSurvey questionnaires to the queXML PDF format, queX, as well as to operate outbound telephone research centers. To operate on the client side, you only a supported web browser and a VoIP client.
Uses a "call outcome" model
In order to manage cases within a Computer Assisted Telephone Interviewing (CATI) system, queXS uses a "call outcome" model, instead of the outdate "case outcome" model. Using final and temporary AAPOR (American Association for Public Opinion Research) codes, the operator can record the outcome of each call. Then, the application automatically choose the best way to operate on a case, based on previous call outcomes.
Under the hood and supported OSes
The application has been engineered to support the PHP 5 or higher server-side programming language, as well as the award-winning MySQL 5 or later database engine. queXS is an OS independent web app that supports all GNU/Linux distributions, various BSD flavors, as well as the Microsoft Windows, Mac OS X and Solaris operating systems. Both 32-bit and 64-bit hardware platforms are supported at this time.
Supported web browsers
queXS's web-based interface has been successfully tested with all the mainstream web browsers on all the aforementioned operating systems. However, we strongly suggest you to use it with either Mozilla Firefox or Google Chrome/Chromium.
Reviewed by Marius Nestor, last updated on October 10th, 2014
- price:
- developed by:
- Adam Zammit (DCARF)
- homepage:
- quexs.sourceforge.net
- license type:
- GPL (GNU General Public License)
- category:
- ROOT \ Communications \ Telephony
In a hurry? Add it to your Download Basket!
- Fixed bug: Quota priority could get below 0
- Fixed bug: Process won't close itself if forced killed before it has a chance to close
- Fixed bug: lp:1338395 - Quotas being incremented in samples that have not yet been accessed
- Fixed bug: Download VoIP client script failing
Application descriptionqueXS is an open source, freely distributed and platform-independent web-based application that has been designed to a...


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The No. 28 ranked Alabama Crimson Tide opened its Southeastern Conference series at Arkansas with a 17-9 victory from Baum Stadium on Friday night. The Tide collected 15 hits in the game, while scoring the most runs ever against the Razorbacks, in 74 games of the all-time series.
Click here for the original story.
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Browse For Aerospace / Aviation Jobs. Find The Job Of Your Dreams On NWjobs Today!
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Want to join a company nationally recognized for outstanding customer service? Interested in flight privileges? Know of someone who might? We are hiring Flight Attendants in Multiple Locations! POSITION INFORMATION ***** We are currently hiring for training classes that will be hel... More Details
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Stress Engineer Sikorsky Aircraft Corporation is a world leader in the design and manufacture of advanced helicopters for commercial, industrial and military uses. Sikorsky helicopters are used by all five branches of the United States armed forces, along with military services and commercial oper... More Details
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Manager Ground Services Job ID: 24620 Location: Seattle, WA Full/Part Time: Full-Time Regular/Temporary: Regular Return to Previous Page PAY The salary range for this position is $52,400.00 - $81,900.00 HORIZON AIR STORY Horizon Air: behind the name are men and women with a "can-do" spirit and a pas... More Details
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太久了, 我在冰泠的空中独自飞翔.
云儿, 请快快送我到日夜思念的地方.
I am floatting in the air alone for so long.
Cloud, please hurry up send me to the place I miss day and night.
by I Am Gao
Canvas Print
Fine art print on bright white, fine poly-cotton blend, matte canvas using latest generation Epson archival inks. Individually trimmed and hand stretched museum wrap over 1-1/2" deep wood stretcher bars. Includes wall hanging hardware.
- 133Promote


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'The Mortal Instruments' Update: Lily Collins Dishes Details on Second Movie
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By charmaine corne clutton | January 30, 2014 11:53 AM EST
The first "Mortal Instruments" movie garnered a lot of fans for the movie adaptation of Cassandra Clare's shadow hunter novel. Lily Collins, plays the role of Clary Fray a normal girl who discovers that she can see the world completely different from the mortal world, where she meets Jace Wayland, played by Jamie Campbell Blower.
REUTERS/Danny Moloshok
Lily Collins joins Taylor Lautner in \"Abduction\". in photo, British actress Lily Collins arrives at the 2011 MTV Movie Awards in Los Angeles, June 5, 2011.
Jamie Campbell Bower plays the role of a shadow hunter who falls in love with Clary Fray. Various turn of events try to bring these two apart but their love is said to move heaven and hell. What a good book for those who want the good to triumph over evil. However, with the first film being a complete failure at the box office, will there be a second movie: "The Mortal Instruments: City of Ashes?"
MTV.c has been able to interview Lily Collins who blatantly stated that she didn't know if there would be a sequel to the first movie, "The Mortal Instruments: City of Bones." The producers of the movie adaptation were trying to change the way the movie is directed and how they can make it better for the avid readers of the shadow hunter book.
Constantin is the production company of "The Mortal Instruments" books, which has six books, namely: "The Mortal Instruments: City of Bones," "The Mortal Instruments: City of Ashes," "The Mortal Instruments: City of Glass," "The Mortal Instruments: City of Fallen Angels," "The Mortal Instruments: City of Lost Souls" and "The Mortal Instruments: City of Heavenly Fire."
Fans are hoping that there would be a sequel to the book as they would love to see Jamie Campbell Bower and Lily Collins back together even if they are just friends. The two dated while filming the first movie but split before the premiere of the film. The best part is that they are still good friends.
Moreover, it seems that Collins has reportedly moved on. Reports say that she has dated "High School Musical's" Zac Efron. For now, fans are left wondering who would play the role of Lily Collin's brother in the movie, Jonathan Morgenstern.
To contact the editor, e-mail:
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text:
Primary Research Article
Size increase in high elevation ground squirrels over the last century
Article first published online: 27 FEB 2012
DOI: 10.1111/j.1365-2486.2012.02644.x
© 2012 Blackwell Publishing Ltd
Global Change Biology
Volume 18, Issue 5, pages 1499–1508, May 2012
Additional Information
How to Cite
Eastman, L. M., Morelli, T. L., Rowe, K. C., Conroy, C. J. and Moritz, C. (2012), Size increase in high elevation ground squirrels over the last century. Global Change Biology, 18: 1499–1508. doi: 10.1111/j.1365-2486.2012.02644.x
Publication History
- Issue published online: 9 APR 2012
- Article first published online: 27 FEB 2012
- Accepted manuscript online: 23 JAN 2012 06:28AM EST
- Manuscript Accepted: 19 NOV 2011
- Manuscript Received: 30 SEP 2011
- Manuscript Revised: 30 SEP 2011
Funded by
- National Science Foundation Grant. Grant Number: DEB 0640859
- National Parks Service
- Yosemite Foundation
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Post Content
Posted by:
Commissioner Joseph G. Murphy, Division of Insurance
At our first hearing today on health care costs for small businesses, we heard from a number of business owners who talked about how increases affect themselves and their employees.
Richard Egan (photo top left), who owns a physical therapy business, said premiums for families have more than doubled for him in two years. "They can literally make me bankrupt," Egan said.
Debra Converse, the head of the Hyannis Area Chamber of Commerce, said her 650 small business members have seen increases of 10 to 39 percent.
Many business owners (like Robert Saquet of Eggers Furniture in Middleboro, photo bottom left) said the rate of insurance increase have eliminated employee raises. Gregory Stone, owner of the Lighthouse Inn in West Dennis, said he still pays 80 percent of his employees' insurance, but has been unable to give them raises for five years.
These are the kinds of issues we have heard on occasion from small business owners, and today's hearing shows that Governor Patrick is right when he says reform is needed now.
We look forward to receiving more testimony this week. If you are unable to attend, please send written comments to email@example.com.
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The challenge is simple: What would you do with $5000 to improve the lives of Rochester students?
1. Submit Your Proposal
Tell us about an improvement you'd like to see on campus, and make sure it fits within the submission guidelines. October 6th – November 2nd.
You can submit your proposal here
2. Vote For Your Favorite
All proposals that meet the criteria for a feasible project will be voted on by the student body. December 2nd – December 7th.
3. We Make It Happen
We will implement the winning project during the Spring Semester. December 8th.
Check out last year's implemented projects by clicking here
Important Dates
More information about your proposal
Follow us on Facebook and Twitter for updates on the $5K CHALLENGE.
Crafting your proposal
We want to hear your ideas; how we can better the campus community one project at a time.
When submitting your proposal, please remember to keep feasibility into account. Remember, this is a 5K challenge. Here are some ways that the $5000 can be used:
- One-and-Done Think of something that costs up to $5000 and we'll buy it. Ex: hanging a $5000 disco ball in Wilson Commons.
- Start Something New Use $5000 to start an annual service. Ex: an annual disco party in Wilson Commons. Disclaimer: We'll reevaluate the service each and every year, so make sure the idea is sustainable!
Editing your proposal
These are some things to keep in mind while writing your submission. Submissions that fail to address the following criteria will be disqualified from the competition.
- Does it benefit the whole campus community?
- Does it improve the student experience?
- Does it fit a need on campus?
- Is it feasible within the given budget?
- Is it inclusive? (Can a lot of students use it?)
Voting for the winner
Voting will take place from Dec 2nd to Dec 7th, and the winning proposal will be announced on December 7th. If you submit the winning proposal, you will be recognized at the State of the SA event as a recipient of the SA Campus Initiative of the Year Award. Please refer to sa.rochester.edu/sa/5k for voting information in the coming weeks.


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- Street View
- Bird's Eye
- Map View
113 Palm Tree Ln, Saltillo, MS 38866
3 beds2 baths1,420 sqft
A Zestimate® home valuation is Zillow's estimated market value. It is not an appraisal. Use it as a starting point to determine a home's value. Learn more
My NotesEdit
- Lot: 8,712 sqft
- Single Family
- Built in 2006
- Cooling: Other
- Heating: Other
- Last sold: Dec 2011 for $119,000
- Price/sqft: $84
- Exterior material: Brick
- Foundation type: Slab
- Roof type: Shake Shingle
- Room count: 6
- # Stories: 1.0
- Floor size: 1,420 sqft
- Heating: Other
- Parcel #: 059T-29-018-58
- Zillow Home ID: 81611171
Zestimate Details
The Value Range is the high and low estimate market value for which Zillow values a home. The more information, the smaller the range, and the more accurate the Zestimate. See data coverage and accuracy table
Don't agree with your home's Zestimate? Owners can edit their home facts to make the Zestimate more accurate. Plus, you can leave an opinion on your Zestimate value below. Just click "Owner Estimate".
The Rent Range is the high and low estimate for which an apartment or home could rent. The more information we have, the smaller the range, and the more accurate the Rent Zestimate. See data coverage and accuracy table
Popularity on Zillow
Home Expenses
Market guideZillow predicts Mississippi home values will increase 1.6% next year.
Learn more about forecast calculations.
For Sale
- William Weed-- beds, -- baths
-- sqft, -- sqft lot, built in --
- 234 County Road 19703 beds, 2 baths
2,376 sqft, 657,756 sqft lot, built in 2002
- 120 Tomy Hawk Trl3 beds, 2 baths
2,280 sqft, 21,780 sqft lot, built in 1996
- 113 Sand Cv3 beds, 4 baths
2,250 sqft, 11,761 sqft lot, built in 2013
Nearby Schools in Saltillo
GreatSchools ratings give an overview of a school's test results. The ratings are based on a comparison of test results for all schools in the state.
Disclaimer: School attendance zone boundaries are supplied by Maponics and are subject to change. Check with the applicable school district prior to making a decision based on these boundaries.
School Rating
Saltillo Elementary (assigned)PK, 3-5 & ungraded4.9 mi
Guntown Middle (assigned)6-8 & ungraded6.2 mi
Saltillo High (assigned)9-12 & ungraded4.9 mi
Data by GreatSchools.org
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Data as of Nov 26
| +0.07 / +0.30%
Today's Change
Today|||52-Week Range
The 5 analysts offering 12-month price forecasts for CVR Refining LP have a median target of 27.00, with a high estimate of 28.00 and a low estimate of 22.00. The median estimate represents a +14.75% increase from the last price of 23.53.
The current consensus among 5 polled investment analysts is to Hold stock in CVR Refining LP. This rating has held steady since November, when it was unchanged from a Move your mouse over past
months for detail
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Pat Roberts: The Tool
By John Amato February 16, 2006 2:35 pm -
Glenn: "There are lots of people who appear to be morbidly depressed -- to the point of conceding defeat -- as a result of yesterday's unilate
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