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NASA: mission accomplished, Kepler – now look harder still
It's been more than three and a half years since the Kepler Space Telescope began its mission as humanity's watcher for Earth-like planets outside of the Solar System. In that time, Kepler has done exactly what was asked of it: provide the data to help identify more than 2,300 exoplanet candidates in other star systems. And so NASA has announced the "successful completion" of Kepler's prime mission. There's one nagging detail, though: we are yet to find a truly Earth-like planet. It's time to alter the parameters of the search. Read More
Due to the masterful efforts of an international team of astronomers, a new super-Earth planet has been discovered within the habitable zone of a star just 42 light years from Earth. Part of a six planetary system, the super-Earth known as HD 40307g has several promising attributes in terms of its ability to support life and because of its relative proximity, it may soon be possible to observe the planet optically. Read More
CHEOPS, the first ESA "small mission," will study super-Earths
The European Space Agency (ESA) is set to give existing orbiting probes, such as COROT and Kepler, a helping hand in studying super-Earths. Selected from 26 proposals, the CHEOPS (CHaracterising ExOPlanets Satellite) spacecraft is the first S-class ("small") mission in the ESA's Science Programme. A partnership between the ESA and the Swiss Space Office, CHEOPS will not seek out new exoplanets, but will instead target nearby, bright stars that are already known to have orbiting planets. Read More
European astronomers working from the European Southern Observatory (ESO) in Chile have discovered a planet slightly more massive than Earth, orbiting a star in the Alpha Centauri triple star system – the nearest stellar system to our planet. Alpha Centauri Bb (as the new exoplanet is called, the star being Alpha Centauri B) is the first Earth-sized body found orbiting a Sun-like star and was discovered by measuring the tiny wobbles of Alpha Centauri B as it moves in response to the gravitational pull of the orbiting planet. It is orbiting Alpha Centauri B every three days and six hours at an orbital radius of six million kilometers (3.7 million miles). The proximity to the star leads to a surface temperature of some 1,500º K (2,250º F/1,232º C) – hot enough to melt granite. Read More
Earth destroyed repeatedly in the name of science
Unlike in old B movies, real scientists don't scream "Fools! I'll destroy them all!" before throwing the switch on their doomsday device. At least, most of the them don't. However, the August 10 issue of the Astrophysical Journal reports that a team of scientists are working on destroying the world - not once, but repeatedly. Fortunately, the world they're destroying exists only in a computer simulation and its destruction is in the service of learning more about planets revolving around other stars. Read More
NASA's Spitzer Space Telescope has detected infrared light emanating from 55 Cancri e, a dark, blazing-hot planet only twice the size of Earth and eight times as heavy. This marks the first time that light has been detected from a planet of such a small size, and the find is telling astrophysicists where to look in their search for signs of life on planets beyond our own. Read More
The blistering hot exoplanet where it snows
Today's weather on HD 189733 b: It will be hazy with high wispy clouds. The wind will be steady from the east at speeds approaching 6000 miles per hour. Daytime temperatures will average a balmy 800 degrees C (1,472 degrees F), while the equatorial hot spot at 30 degrees longitude is expected to top 900 degrees C (1,652 degrees F). But, there is a high chance of silicate snow showers, with accumulations expected except in the vicinity of the hot spot. Read More
Waterworld: A new class of exoplanet is discovered
Planets orbiting two stars, giant super-Earths and worlds racked with boiling rock storms - these are just some of the galactic oddities among the more than 700 exoplanets discovered in the past 20 years. Now there's another new class of extrasolar planet to add to the list - the waterworld. Read More
New "Super-Earth" discovered only 22 light years away
An international team of scientists led by Professors Guillem Anglada-Escudé and Paul Butler from the Carnegie Institution for Science in the U.S. has discovered a potentially habitable Super-Earth that's "just" 22 light years away. The new Super-Earth has a mass that is 4.5 times larger than that of our planet and it revolves around its parent star in 28 days - a star that is significantly smaller than ours. This remarkable new discovery suggests that habitable planets could exist in a wider variety of environments than previously believed. Read More
Kepler spacecraft discovers tiniest solar system yet found
Astronomers using data from NASA's Kepler mission have discovered the tiniest solar system found so far. The system consists of a single red dwarf star, known as KOI-961 and three planets which are 0.78, 0.73 and 0.57 times the radius of Earth. The planets are thought to be rocky - like Earth - but orbit much closer to their star making them too hot to be habitable. Read More
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MS Word English To Thai and Thai To English Software 7.0
Document converter
The software can easily read the text contained within Word documents, then convert it to either to Thai or English, using a powerful translating engine. The software supports only files created with Microsoft Word 2000 edition or newer, meaning it can process both DOC and DOCX formats.
You may easily load a multitude of files from several folders or import an entire directory and let the software detect the supported files. All the files listed in the working space can be processed simultaneously, since the software can perform batch conversion. It does not modify the file's type, but converts the text contained within to another language.
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MS Word English To Thai and Thai To English Software is useful to people who need to translate official documents in a short time. The software can perform the text conversion within seconds and maintain its formatting options. Thus, not only can you save time with the translation but you do not need to rewrite the text. Moreover, the program supports translating English texts to Thai language, but also vice versa.
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In a hurry? Add it to your Download Basket!
Application descriptionMS Word English To Thai and Thai To English Software offers a solution to users who want to convert Word files from En...

subset: commoncrawl


text:
European Journal of Dermatology
The official journal of the European Dermatology Forum
The European Journal of Dermatology is an internationally renowned journal for dermatologists and scientists involved in clinical dermatology and skin biology.
Original articles on clinical dermatology, skin biology, immunology and cell biology are published, along with review articles, which offer readers a broader view of the available literature. Each issue also has an important correspondence section, which contains brief clinical and investigative reports and letters concerning articles previously published in the EJD.
The policy of the EJD is to bring together a large network of specialists from all over the world through a series of editorial offices in France, Germany, Italy, and Spain.
The European Journal of Dermatology is indexed in Medline and the Current Contents and the continually improving Impact Factor is evidence of its high quality and international recognition.
The online version of European Journal of Dermatology is now available to both readers and authors. All articles published since 1997 can now be accessed online. Recent articles are available by pay per view or by subscription while older ones have free access.
Impact Factor 2013: 1,956
Volume 24, issue 4, July-August 2014
Review: Higher vitamin D status and supplementation may be associated with risks
Kaveri KORGAVKAR, Michael XIONG, Martin A. WEINSTOCK
Management of scars: updated practical guidelines and use of silicones
Sylvie Meaume, Anne Le Pillouer-Prost, Bertrand Richert, Diane Roseeuw, Javid Vadoud
Evidence-based review of photodynamic therapy in the treatment of acne
Weifeng Zheng, Yan Wu, Xuegang Xu, Xinghua Gao, Hong-Duo Chen, Yuanhong Li
The European Medicines Agency approval of ingenol mebutate (Picato) for the cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults: Summary of the scientific assessment of the Committee for Medicinal Products for Human Use (CHMP)
Kyriaki Tzogani, Nithyanandan Nagercoil, Robert James Hemmings, Bekkai Samir, Jean Gardette, Pierre Demolis, Tomas Salmonson, Francesco Pignatti
Investigative reports
Study of T helper (17) and T regulatory cells in psoriatic patients receiving live attenuated varicella vaccine therapy in a randomized controlled trial
Mohammad A. El-Darouti, Rehab A. Hegazy, Rania M. Abdel Hay, Laila A. Rashed
OPEN ACCESS available for your articles
As authors, you may ask to have your articles freely available in the website. During the submission process, you can take this option.
Submit your article to European Journal of Dermatology!
If you are author and want to be published in European Journal of Dermatology, click here to consult the instructions for authors.
Ahead of print
Unmet needs in the treatment of psoriasis
By Knud Kragballe, Peter C.M. van de Kerkhof, Kenneth B. Gordon
Porokeratoses: an update of clinical, aetiopathogenic and therapeutic features
In vivo assessment of the effect of a cream containing Avena Rhealba extract® and hyaluronic acid on the restoration of the skin barrier in de-epidermised skin produced with an erbium-YAG laser
By Mélanie Sabadotto, Jennifer Theunis, David Black, Valérie Mengeaud, Anne-Marie Schmitt
Deep penetrating nevus-like borderline tumors: A unique subset of ambiguous melanocytic tumors with malignant potential and normal cytogenetics
By Cynthia M. Magro, Ronnie M. Abraham, Ruifeng Guo, Shibo Li, Xuan Wang, Steven Proper, A. Neil Crowson, Martin Mihm
Free articles
Recommendations for pimecrolimus 1% cream in the treatment of mild-to-moderate atopic dermatitis: from medical needs to a new treatment algorithm
By Thomas Luger, Linda De Raeve, Carlo Gelmetti, Talia Kakourou, Alexandra Katsarou, Julien Lambert, Marie-Anne Morren, Arnold Oranje, Mireille Ruer, Server Serdaroglu, Antonio Torrelo, Thomas Werfel
Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation
Efficacy and safety of clindamycin phosphate 1.2%/tretinoin 0.025% formulation for the treatment of acne vulgaris: pooled analysis of data from three randomised, double-blind, parallel-group, phase III studies
By Brigitte Dréno, Vincenzo Bettoli, Falk Ochsendorf, Alison M. Layton, Montserrat Perez, Rada Dakovic, Harald Gollnick
Point prevalence and risk factors for food allergy in a cohort of 386 children with atopic dermatitis attending a multidisciplinary dermatology/paediatric allergy clinic
By Claire Mailhol, Françoise Giordano-Labadie, Valérie Lauwers-Cances, Alfred Ammoury, Carle Paul, Fabienne Rance
Reduction in lesions from Lmax: a new concept for assessing efficacy of field-directed therapy for actinic keratosis. Results with imiquimod 3.75%
By Eggert Stockfleth, Girish Gupta, Ketty Peris, Selim Aractingi, Rada Dakovic, Agustin Alomar


text:
John Williams Lyrics
Overview / Lyrics (see all) / Photos / Videos / News
THE RETURN TO BOSTON Lyrics
War of the Worlds [SOUNDTRACK] Other Album Songs
"THE RETURN TO BOSTON" is track #12 on the album War of the Worlds [SOUNDTRACK].
"THE RETURN TO BOSTON" is track #12 on the album War of the Worlds [SOUNDTRACK].
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What chart rank did the song debut? What is the song about? Has it won any awards?, etc.Cancel Submit
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Jack Johnson, Phoenix, Thirty Seconds…
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listen now Is '7/11' The Best Beyonce Music Video Of All Time?
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text:
New research published today out of the University of Calgary's Hotchkiss Brain Institute (HBI) uncovers a mechanism to promote growth in damaged nerve cells as a means to restore connections after injury.
Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system. His study was published in the prestigious journal Nature Communications, with lead authors Drs. Kim Christie and Anand Krishnan.
"We made the surprising discovery that a protein called Retinoblastoma (Rb) is present in adult neurons," explains Zochodne. "This protein appears to normally act as a brake – preventing nerve growth. What we have shown is that by inactivating Rb, we can release the brake and coax nerves to grow much faster," says Zochodne, a professor in the Department of Clinical Neurosciences.
Zochodne and his team decided to look for Rb in nerve cells because of its known role in regulating cell growth elsewhere in the body.
"We know that cancer is characterized by excessive cell growth and we also know that Rb is often functioning abnormally in cancer," says Zochodne. "So if cancer is able to release this brake and increase cell growth, we thought we'd try to mimic this same action in nerve cells and encourage growth where we want it."
The researchers were able to shut down Rb for a short amount of time and did not observe any negative results, leading them to feel optimistic that this could one day be used as a safe treatment for patients suffering from nerve damage.
So far, Zochodne is only investigating this technique in the peripheral nervous system. Peripheral nerves connect the brain and spinal cord to the body and without them, there is no movement or sensation. Peripheral nerve damage can be incredibly debilitating, with patients experiencing symptoms like pain, tingling, numbness or difficulty coordinating hands, feet, arms or legs.
For example, diabetic neuropathy is more common than multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis (ALS) combined. More than half of all diabetics have some form of nerve pain and currently there is no treatment to stop damage or reverse it.
Developing safe and effective therapies for conditions such as peripheral nerve disorders requires the ability to take investigations from cells in a petri dish to patients in a clinic. Zochodne and his team have been able to do that thanks in part to a preclinical facility that opened at the HBI in 2010. The Regeneration Unit in Neurobiology (RUN) was created through a partnership between the HBI, the University of Calgary and the Canada-Alberta Western Economic Partnership Agreement.
"The RUN facility has been critical for this research, says Zochodne. "It provides the resources and cutting-edge equipment that we need all in one facility. RUN has allowed us to take this idea from nerve cells, to animal models and eventually will help us investigate whether it could be a feasible treatment in humans. It's an incredible asset".
This research was funded by the Canadian Institutes of Health Research.
Marta Cyperling | Eurek Alert!
Further information:
Further reports about: > HBI > Neurobiology > Regeneration > damage > diabetic > injury > movement > protein
Microbial Communities for Health and Environment : Precise Measurements of Microbial Ecosystems
26.11.2014 | Universität Luxemburg - Université du Luxembourg
How various brain areas interact in decisions
26.11.2014 | Universität Zürich
Regional economic cooperation in Central Asia
21.11.2014 | Event News
13.11.2014 | Event News
36th Annual IATUL Conference 2015: Call for papers and posters
12.11.2014 | Event News
Siemens expands software for mobile data management in the process industry
26.11.2014 | Trade Fair News
Microbial Communities for Health and Environment : Precise Measurements of Microbial Ecosystems
26.11.2014 | Life Sciences
VTT demonstrates new technique for generating electricity
26.11.2014 | Power and Electrical Engineering


text: Strict Standards: Redefining already defined constructor for class XML_Parser in /home/sites/www.americanpoems.com/web/store/aom/includes/os.php on line 1188 Strict Standards: Declaration of XML_Parser::raiseError() should be compatible with PEAR::raiseError($message = NULL, $code = NULL, $mode = NULL, $options = NULL, $userinfo = NULL, $error_class = NULL, $skipmsg = false) in /home/sites/www.americanpoems.com/web/store/aom/includes/os.php on line 1604 Strict Standards: Declaration of XML_Unserializer::startHandler() should be compatible with XML_Parser::startHandler($xp, $elem, &$attribs) in /home/sites/www.americanpoems.com/web/store/aom/includes/os.php on line 3503 Strict Standards: Declaration of Cache_Lite_File::get() should be compatible with Cache_Lite::get($id, $group = 'default', $doNotTestCacheValidity = false) in /home/sites/www.americanpoems.com/web/store/aom/includes/cache.php on line 1020 American Poems: Kindle eBooks: Pick-Up Line: A New Orleans Love Story Home Apparel Appliances Books DVD Electronics Home & Garden Kindle eBooks Magazines Music Outdoor Living Software Tools & Hardware PC & Video Games Search All Products Apparel Appliances Arts & Crafts Automotive Baby Beauty Books Computers DVD Electronics Gourmet Food Grocery Health Home & Garden Industrial & Science Jewelry Kindle eBooks Kitchen Magazines Miscellaneous Mobile Apps MP3 Downloads Music Musical Instruments Office Products Outdoor Living Pet Supplies Photo & Camera Shoes Software Sporting Goods Tools & Hardware Toys VHS Video On Demand PC & Video Games Watches Wireless Wireless Accessories Advanced Search Sitemap View Cart Checkout Location: Home » Kindle eBooks » Pick-Up Line: A New Orleans Love Story Pick-Up Line: A New Orleans Love Story enlarge Author:Patty Friedmann Publisher:booksBnimble Category:eBooks In Stock Sales Rank:149,712 Format:Kindle eBook Language:English (Published) Media:Kindle Edition Pages:304 Publication Date:November 12, 2013 ASIN:B00D5XYRSK Similar Items: Mr Right and Mr Wrong (a romantic comedy) A Little Bit Ruined: Eleanor Rushing #2: Eleanor Meets Hurricane Katrina From One Place to Another The London Stories (Emily Castles Mysteries) The Charm Bracelet Editorial Reviews: Synopsis(Originally titled Side Effects ) ROMANCE IS THE BEST PAIN-KILLER… Cupid's working overtime in the unlikely venue of N.O. Drugs, where plus-sized beauty Ciana Jambon works with dread-locked pharmacy student Lennon Israel, who's so handsome, so meticulous he just has to be gay. But she can't help herself—she's got the crush of the century. Unbeknownst to her, Lennon's carrying his own torch. Family problems distract both of them (alongside the true New Orleans oddballs who scuffle between the Seasonal Specials and Depends aisles) until tragedy leaves Ciana reeling. Lennon wonders if there's a murderer in her clan, and he's pretty sure he's the only one who can help. What woman can resist a knight in shining armor? Friedmann's witty portrayal of Ciana's and Lennon's families from hell, as well as the deliciously dysfunctional relatives of their wise co-worker, Vendetta Greene, will have you laughing out loud as well as nodding in recognition. WARNING: This is anything but a formula romance. But it is a great love story—and the perfect prescription for anyone feeling tired, rundown, and depressed from reading the same old thing over and over again. The only side effect is a slight watering of the eyes as the first tender shoots of love start to bud and blossom. A veritable (prescription drug) cocktail of Walker Percy's southern elegance laced with the zany black comedy of the Silver Linings Playbook. "Friedmann's charming story of the ... affection among three diverse co-workers at a New Orleans pharmacy also now reads as a tribute to a unique American city." -Publishers Weekly "The story is by turns humorous and heartbreaking, and the author is adept at capturing that quirky combination of love and resentment that characterizes so many families. Friedmann's themes of sibling rivalry and unlikely friendships will linger with readers." -School Library Journal CERTAIN CONTENT THAT APPEARS ON THIS SITE COMES FROM AMAZON SERVICES LLC. 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text:
Climate change march happens Sunday in Hood River
A Columbia Gorge climate gathering and march takes place Sunday in Hood River at Riverside Community Church, Fourth and State streets.
Hazy skies in Gorge caused by fire near Estacada
If you've noticed some smoky skies and spectacular sunsets and sunrises in the Gorge lately, a wildfire currently burning near Estacada is the culprit.
Wyoming appeals Oregon's denial of coal port
CHEYENNE, Wyo. (AP) — Wyoming is appealing Oregon's recent decision to deny an application to build a coal terminal at the Port of Morrow, on the Columbia River.
Groups plan suit over Northwest oil-response plan
SEATTLE (AP) — Environmental groups say they plan to sue the federal government for failing to ensure that regional oil-response plans don't harm endangered species.
Wash. governor says no to extending Hanford deadline
RICHLAND, Wash. (AP) — Gov. Jay Inslee and Attorney General Bob Ferguson said they will not extend Friday's deadline for resolving a dispute with the U.S Department of Energy over cleanup of the Hanford Nuclear Reservation, the nation's most polluted nuclear weapons production site.
Record return
As predicted, this year's run of Fall Chinook salmon returning to the Columbia River is setting all-time historic records.
Gorge Commission budget spurs protest
For the first time in its 27-year history, both the chair and vice chair of the Columbia River Gorge Commission have resigned their posts – but are staying on the commission – in a disagreement over the budget.
Green again, with work
We appreciate the Aug. 30 article on the recent Indian Creek site fire.
ODOT submits plans for new Historic Hwy segment
Work likely won't start on it for at least a few months, but construction plans for the next phase of the Historic Columbia River Highway State Trail have been submitted to the county for permitting.
Pinchot Collaborative turns focus to Upper WS River-Gotchen Creek
Last week, a group of residents who share a common interest in taking care of the Gifford Pinchot National Forest gathered around the Trout Lake Big Tree to collaborate on how to do so.
Dog park list narrowed down
Parks-Rec focus is on undeveloped sites
An ad hoc committee formed to find a suitable location for a dog park in Hood River has narrowed down its list of potential sites and largely scrapped plans to place the facility on already existing park sites.
OWEB offers grants for watershed health
Do you have natural resource concerns on your property, but don't have the funds to fix them?
It's still summer:Ways to save water
Rain actually does go away on summer days in the Pacific Northwest and during this dry time, when vegetables and flowers bask in sunlight, water use and costs can increase substantially.
Hiker rescued after fall on Mt. Adams
YAKIMA, Wash. (AP) — The Yakima County sheriff's office says a hiker who fell and injured himself on Mt. Adams on Sunday has been rescued.
Fire damages planting area along 12th Street
A kite stuck on power lines caused sparks to fly and a grass fire to break out on the Heights on Friday.


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Canada's leading distributor of Presentationand Visual Communication Solutions.
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text:
QB Teddy Bridgewater addressed the media following Sunday's 24-21 loss to the Packers.
The Green Bay Packers looked to get a pivotal division win against the Minnesota Vikings, quarterback Aaron Rodgers played well throwing for 209 yards and two touchdowns. Packers win a close one 24-21.
Head Coach Mike Zimmer addressed the media following Sunday's 24-21 loss to the Packers.
Minnesota Vikings quarterback Teddy Bridgewater finds wide receiver Greg Jennings for a 5-yard touchdown. Following the Play, Bridgewater throws to wide receiver Charles Johnson for a successful 2-point conversion.
Green Bay Packers quarterback Aaron Rodgers slips and is sacked by Minnesota Vikings defensive end Brian Robison for a loss of 2 yards.
Minnesota Vikings quarterback Teddy Bridgewater throws a 22-yard touchdown pass to wide receiver Charles Johnson.
World War II Veterans Captain Tom Homdrom (Army), Corporal Wayne DeVries (Marine) and Quartermaster 3rd Class Bill Ringold (Navy) were recognized for their commitment and service to our country at halftime of Sunday's game.
The Vikings saluted former Navy Lieutenant and Minnesota Football Coaches Association Hall of Fame member Stan Nelson during halftime of Sunday's game.
Sergeant Thomas Block, a Minnesota native and a member of the 3rd Battalion of the 75th Ranger Regiment, sounded the Gjallarhorn prior to kickoff of Sunday's game. Block was attacked by a suicide bomber while patrolling in southern Afghanistan.
Go on the field prior to Sunday's game vs. the Packers and check out pregame highlights.
NFL Media Insider Ian Rapoport reports the latest on Adrian Peterson, including Peterson's plans to seek damages for having to sit out the season.
Hear the story of Stan Nelson, a World War II Veteran who was part of D-Day for the invasion of Normandy, who came home after serving to coach high school football at Anoka for 25 years. Plus, watch as Nelson sits down with another World War II football junkie: Bud Grant.
Head Coach Mike Zimmer talked with the voice of the Vikings, Paul Allen, about Green Bay's hot starts to games and how opponents react, Teddy Bridgewater's development, the difference Clay Matthews can make in a game and more.


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The Tamil remake of Telugu film Ready took approximately Rs 58 lakhs from 18 Chennai screens. Family audiences seem to have liked the film.
At number two is Enthiran, which is holding on well especially at Chennai multiplexes.
In third position is Prabhu Solomon's Mynaa, which is being appreciated and liked by the youth. It may turn out to be Diwali's sleeper hit, as word of mouth is very encouraging.
Va Quarter Cutting carries mixed reports and has taken an average opening and is at number four.
Boss Engira Bhaskaran is at fifth place.


text: This is always one of the top restaurants on our list in Park City. The food is excellent and very creative. The chef is pleasantly accomodating to alergy changes and the service is outstanding. When they serve the bread, try it even if you don't normally eat carbs - you will not be disappointed. From reception to end, the staff... More


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The first section of Betwixt and Between: The Honors Pathway was a crucial step in my assimilation process of becoming a college student.
Megan Ruggiero, English major
In 2012 the college celebrated 175 years as an institution of teaching and learning. Visit the 175th website for more information and to view photos of the events.
Lupinus arizonicus
Height: Up to 2'
Leaves: 1 1/2" long and palmate with 7 to 9 leaflets. They are green on top and lighter and hairy below.
Flowers/Fruit: In bloom June to October. The flowers are pink with a yellow center and 1/2" wide. They are clustered at the top of the stem.
Form/Habitat: Below 3,000'. Found on roadsides and washes.
Click here to return to the Desert Herbarium Home Page.
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November 26, 2014
BUDAPEST, Hungary (AP) - Hungarian police say they are investigating an incident in which an elderly man may have been mauled to death by two donkeys.
It happened May 13 in the western Hungarian town of Magyarszecsod, when Sandor Horvath, a 65-year-old retired firefighter, was apparently pulled off his motorcycle by the donkeys kept on a lot neighboring his small farm. The animals likely dragged him some 50 meters (55 yards), biting and trampling him.
Vas County Police said Tuesday they are still working on the case but had no new developments to report.
The results of an autopsy to determine the exact cause of death have not been released.
The donkeys are being kept under observation for another week before their fate is decided.
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Fluid pressure is sensed by applying it differentially to a diaphragm, causing the diaphragm to vibrate at a natural frequency, and sensing the stressing of the diaphragm in terms of the resulting change in the natural frequency. The frequency of vibration is measured essentially by counting cycles and offsetting the count to introduce a reference pressure. Improved accuracy is obtained by forming the diaphragm of preferred magnetic materials having low temperature dependence of elasticity.
Claims available in
Description (OCR text may contain errors)
United States Patent Feuer et a1.
Oct. 2, 1973 DIGITAL PRESSURE TRANSDUCER Inventors: Robert Feuer, Wayne; Donald A.
Ball, Warren, both of NJ.
3,295,360 1/1967 Dimeff,... 73/398 C 3,425,281 2/1969 Barz 73/398 C 3,071,725 1/1963 McWaid.. 73/398 R 3,595,069 7/1971 Fowler 73/672 Primary ExaminerDonald O. Woodiel Azt0rneyChar1ton M. Lewis [57] ABSTRACT Fluid pressure is sensed by applying it differentially to a diaphragm, causing the diaphragm to vibrate at a natural frequency, and sensing the stressing of the diaphragm in terms of the resulting change in the natural frequency. The frequency of vibration is measured essentially by counting cycles and offsetting the count to introduce a reference pressure. Improved accuracy is obtained by forming the diaphragm of preferred magnetic materials having low temperature dependence of elasticity.
4 Claims, 2 Drawing Figures 980 P20524114. 3/ Coy/WE"? g2 70 W33 L Ca N El? r90 535- v T FFSE 92 9 an 0 I I PM 7 2 PEG/s72? c'a/wpurse 9.4
DIGITAL PRESSURE TRANSDUCER I This invention has to do with pressure transducers for sensing fluid pressure and producing an electrical signal that represents the magnitude of the pressure.
Many such pressure transducers have been described in which the pressure to be measured is applied to a diaphragm and the resulting diaphragm deflection is translated into an electrical signal. It is also common practice to sense directly the stress produced in the diaphragm, as by means of a piezoresistive element mounted on a face of the diaphragm or formed integrally in a diaphragm face. Such previous devices normally produce an output signal of analogue form, and are thus subject to the well known limitations of accuracy and reliability that are inherent in the manipulation of analogue signals.
An important object of the present invention is to provide a pressure transducer capable of producing an output signal that is inherently digital in nature. The improved accuracy and reliability of digital techniques are then available throughout the manipulation of the data.
Pressure transducers in accordance with that aspect the invention are particularly suitable for supplying pressure information to a digital computer. 'Since the pressure information can be initially produced in digital form, no analogue to digital conversion of the data is required.
A further object of the present invention is to provide a pressure transducer having reduced sensitivity to externally impressed accelerations.
The invention is further capable of producing pressure transducers that are substantially compensated with respect to temperature throughout a selected range of temperature variation.
Those and other objects and advantages of the invention are accomplished by causing the pressuresupporting diaphragm to vibrate at a natural frequency of vibration, typically in its-fundamental mode, and by sensing the stressing of the diaphragm in terms of the resulting change in its natural frequency of vibration. The frequency of vibration is measured essentially by counting the cycles of vibration perunit of time, which is basically a digital operation and can readily be arranged to produce an output signal of digital form.
In preferred form of the invention, vibratory movement' of the pressure-supporting diaphragm is sensed by an electrical circuit coupled capacitively to the diaphragm and developing an electrical signal in response to each cycle of the movement. Those signals are amplified and adjusted in phase, and are applied to a drive motor, typically of variable reluctance type, for driving the diaphragm vibration. The signals are also supplied to suitable counting and computing circuits for developing a digital difference signal that represents the departure of the actual frequency of vibration from its value for a selected reference pressure, typically zero. That digital difference signal can be further manipulated in any desired manner. In particular, it is typically converted by asuitably programmed digital computer to a form directly proportional to the applied pressure.
By utilizing capacitive coupling forsensing the diaphragm movement, the invention avoids any increase in the effective mass of the diaphragm and imposes minimum reactive loading of the diaphragm due to the electrical pickoff. Externally impressed accelerations have only negligible effect upon the measured frequency of the diaphragm vibration, especially since the measurement involves averaging over a large number of cycles.
A full understanding of the invention, and of its further objects and advantages, will be had from the following description of a preferred manner of carrying it out. The particulars of that description, and of the accompanying drawings which form a part of it, are intended only as illustration and not as a limitation upon the scope of the invention.
In the drawings:
FIG. 1 is a somewhat schematic axial section representing an illustrative transducer assembly in accordance with the invention; and
FIG. 2 is a schematic block diagram representing an illustrative electrical system for use with the transducer assembly of FIG. 1.
An illustrative transducer in accordance with the invention is shown in axial section in FIG. 1. The cylindrical housing member 10 with the axis 11 is divided by the transverse wall 12 to form the main transducer chamber 14 and the electronics chamber 16. The latter chamber is closed by the cover plate 17, which carries on its inner face the circuit board 18. Transducer chamber 14 is closed by therigid end wall 20, which is located axially by the internal housing flange 22 and is typically secured by solder or the like, as indicated at 24.
The diaphragm proper 30 is mounted on the inner end of the supporting sleeve 32, being preferably formed integrally with the sleeve as a unitary diaphragm member 34. Sleeve 32 is rigidly mounted at its other end on the inner face of end wall 20, on which it is axially centered by the peripheral flange 26. The joint between diaphragm member 34 and end wall 20 is sealed, as by solder, at 35, dividing transducer chamber 14 into mutually isolated inner and outer pressure chambers 14a and 14b on opposite sides of the diaphragm. Those chambers are supplied with fluid pressures from any desired respective sources via the tubes 26 and 28, which are mounted in sealed relation in bores in end wall '20 and in transverse housing wall 12, respectively. Chamber 14b is typically maintained at a selected reference pressure, ordinarily zero, while the pressure to be measured is supplied via tube 26 to chamber 14a, stressing the diaphragm increasingly with increasing value of the pressure.
Diaphragm 30 is caused to oscillate transversely of its plane and in its fundamental mode. The driving force for maintaining that oscillation is typically developed by the electromagnetic motor indicated at 40. The solenoid winding 42 is mounted on the magnetically permeable core 44, which has one end rigidly mounted coaxially on end wall 20 and the other end closely spaced at 46 from the central portion of diaphragm 30. The diaphragm, its supporting sleeve 32 and housing end wall 20 are all formed of suitable magnetically permeable material, forming with core 44 a magnetic circuit for winding'42 that is completely closed except for the air gap at 46.
'Electrical'connections to solenoid winding 42 are provided in any suitable manner, as by two electrical terminals, of which one is shown at 47, mounted in electrically insulated relation in end wall 20 and frictionally engaging suitable fittings 48 mounted on core 44 by means of the insulating disk 49.
Movement of diaphragm 30 is sensed by variations in the electrical capacity between the diaphragm itself and the pickoff plate 50. That plate is rigidly mounted on housing wall 12 by means of the electrically insulative, cylindrical support 52, which is typically secured and centered in a coaxial bore 53 in wall 12. Plate 50 is closely spaced from the diaphragm on the side opposite to driving motor 40 by a distance indicated at 51, which varies with the pressure applied to the diaphragm. The plate is electrically connected to the terminal 54, which projects through bore 53 into chamber 16 and is accessible for connection to the amplifying and processing circuitry carried by circuit board 18. That circuitry is indicated only schematically at 56 and preferably includes at least the elements indicated in FIG. 2. As there shown, pickoff plate 50 is charged to the normal potential V via the blocking resistor R1. Variation in capacitance between plate 50 and grounded diaphragm 30, caused by diaphragm oscillation, then produces a corresponding periodic sinusoidal variation in the plate potential about its normal value. That sine wave pickoff signal 58 is coupled via the capacitor C1 to the gate of the negative channel field effect transistor O, which acts primarily as a buffer. FET Q has its source grounded and its drain connected to the voltage source +V via the load resistor R2. Bias is provided by the voltage dividing resistors R3 and R4, with the current limiting resistor R5. The output from FET Q is supplied to a phase converter, shown as the amplifier Ml with capacitive feedback via C2, which adjusts the phase of the sine wave typically by approximately 90. The resulting signal 59 is supplied as timing control to the square wave generator 60, typically comprising a zero crossing detector which controls a switching circuit in response to zero value of the sine wave. The amplitude of the resulting square wave on the line 62 is preferably set at a definite value independent of the pickoff signal, as by the saturating amplifier M2, which also acts as a buffer. The output square wave 63 from M2 is supplied via the line 64 to the winding of motor 40, with phase and amplitude suitably adjusted at M1 and M2, respectively, to produce approximately the desired amplitude of diaphragm oscillation. That oscillation amplitude is preferably much less than the range of diaphragm deflections due to the pressures to be measured. Since the Q of the diaphragm is intrinsically high, the power transmitted from motor 40 to the diaphragm is then extremely small, and the slight amplitude variation with pressure or with other factors such as temperature have negligible effect upon the frequency, which corresponds accurately to the natural frequency as modified by the pressure-imposed stress.
The pickoff signal from plate 50 is also utilized as a measure of the frequency of the diaphragm oscillation for producing an indication of the pressure that is acting on the diaphragm. If an output in analogue form is desired, the frequency signa may be converted in any suitable manner to a current or voltage proportional to the frequency. That analogue signal may then be indicated directly or may be otherwise processed in any desired manner as a measure of the existing pressure.
It is ordinarily preferred to maintain the digital nature of the pickoff signal throughout any required manipulations and calculations. Illustrative circuitry for that purpose is shown in FIG. 2. The clock 70 produces on the line 72 a series of timing pulses of accurately maintained frequency, typically controlled by a crystal oscillator. That clock signal is gated under control of the diaphragm oscillation to produce a train of clock pulses corresponding in duration to a selected number of diaphragm oscillations. The number of pulses in each train is then directly proportional to the oscillation frequency averaged over the selected number of oscillations. That averaging produces a count of convenient magnitude and reduces the effect of any high frequency noise in the pneumatic system.
For such gating of the clock pulses, the square wave signal on line 64 is supplied to the frequency divider 74 which produces on the line 75 a control signal that continues for the selected number of diaphragm oscillations, for example 64. That control signal enables the gate 76, typically a conventional AND gate, to transmit clock pulses to the line 78. The clock frequency is typically from 10 to 100 times higher than the sensor oscillation frequency, so that the number of pulses in each transmitted train is of the order of 1,000 or more.
The gated train of clock pulses on line 78 is supplied both to the AND gate 82 and to the programmable counter 80. That counter also receives via the line 83 from the offset circuit 84 a digital signal representing a reference or offset number of counts, which is to be effectively subtracted from the pulse train count and which corresponds to the pulse train length for a selected reference pressure, typically zero. Counter comprises circuitry for generating a digital signal continuously representing the number of pulses as they are received from line 78, and circuitry for comparing that signal with the reference count signal received from line 83. As soon as the pulse count becomes equal to the reference count, counter 80 produces on the line 81 a gating signal which enables gate 82. Any clock pulses in the train in excess of the reference count are transmitted by gate 82 via the line 85 to the counter 90, whose content is therefore a zero base number representing the pressure excess over the reference pressure. At the completion of each pulse train,that number is shifted in parallel via the lines 92 to the storage register 94 for transfer to any desired utilization device, shown illustratively as the digital computer 96. Computer 96 typically includes means for translating the pulse count into a digital representation directly proportional to the pressure acting on the diaphragm, taking account of the nonlinear relationship between that pressure and the diaphragm frequency. That relationship can be calculated with good accuracy from the known behavior of an oscillating diaphragm and the properties of the material from which it is made. However, it is generally preferred to determine the required relationship empirically by direct test with known pressures applied to the diaphragm, and to program computer 96 in accordance with such test results. The computer output on the line 98 is typically a digital signal representing directly the actual pressure, and is supplied to any desired utilization device, represented schematically at 100.
The offset count supplied from circuit 84 is ordinarily made to correspond to the number of pulses in the pulse train from gate 76 when the pressure in chamber equals the reference pressure in chamber 14b. Especially when the reference chamber is evacuated, the offset count, once determined, is essentially constant, and may be set into circuit 84 manually and then remain fixed. On the other hand it is feasible to make the offset count correspond to any selected pressure value, which may be varied under different conditions, the programming of computer 96 being modified accordingly. Offset circuitry 84 is then preferably coupled to computer 96, as indicated by the line 99, and may be physically integrated entirely or partially in the computer. It is then feasible to program the computer to take account of such factors as temperature both in the computation performed on the count from register 94 and in the offset count that is supplied via line 83 to programmable counter 80.
Whereas the diaphragm itself and the other portions of the magnetic circuit can be made in principle from a wide variety of magnetically permeable materials, it is highly desirable to eliminate so far as possible variations in output due to temperature variations. In accordance with a further aspect of the invention, it has been discovered that remarkably effective temperature compensation is obtainable by forming the diaphragm, and preferably other parts of the magnetic circuit, of an alloy having the general properties of the iron, nickel, chromium and titanium alloy which is available commercially under the trade name Nl-SPAN-C alloy 902. The primary ingredients of that alloy are approximately 48 percent iron, 42 percent nickel, 5 percent chromium and 2.5 percent titanium. Such alloys are capable of providing a useful range of properties in response to suitably selected small modifications of the proportions of ingredients and to selected heat treatment of the product. In such alloys the thermoelastic coefficient, which is the rate of change of the modulus of elasticity with change of temperature, can be adjusted quite accurately in known manner by suitable heat treatment, the range of. available values of the thermoelastic coefficient typically including zero.
Although the required heat treatment for producing a given value of thermoelastic coefficient depends somewhat upon the frequency at which the device is to operate, that dependence virtually disappears for frequencies above about 800 cycles per second. Accordingly, if the device is designed to operate at or above that frequency for all applied pressures, and if the material is treated to produce a selected low value, typically essentially zero for the thermoelastic coefficient for such relatively high frequencies, that selected value is accurately maintained over the entire range of frequencies resulting from variations in the applied pressure. Such close control over the thermoelastic coefficient of the diaphragm permits highly satisfactory compensation of any tendency of its natural frequency to vary with temperature. Temperature variation of the clearance 51 between the diaphragm and pickoff plate 50 is controlled by suitable selection and heat treatment of the material of housing 10, taking account of the heat treatment to which the diaphragm assembly itself is subjected.
In illustrative form of the invention, diaphragm 30 is about three-fourths inch in diameter and is lapped to a thickness of about 0.006 inch. With the material described above, the natural frequency of the diaphragm is then about 3,000 Hz at zero pressure differential, and increases to 6,000 Hz or more at a pressure differential of 1 atmosphere. It may be seen from those illustrative values that a wide range of diaphragm dimensions are available which lead to natural frequencies well above the threshold of 800 Hz at which the thermoelastic coefficient becomes essentially independent of frequency.
We claim: 1. A pressure transducer, comprising in combination a resilient diaphragm formed of an alloy having substantially zero thermoelastic coefficient for oscillation frequencies higher than av predetermined threshold value, the form of the diaphragm being such that its natural frequency of oscillation is higher than said threshold value, structure for applying a fluid pressure differentially to the diaphragm to stress the same transversely, means for driving the so stressed diaphragm to oscillate at its natural frequency, sensing means responsive to the diaphragm movement, and means for deriving from the frequency of the sensed movement an indication of the magnitude of the applied pressure. 2. A pressure transducer according to claim 1, and in which said diaphragm consists essentially of about 48 percent iron, 42 percent nickel, 5 percent chromium and 2.5 percent titanium and has substantially zero thermoelastic coefficient for oscillation frequencies higher than a threshold value of about 800 cycles per second, and the form of the diaphragm is such that its natural frequency of oscillation is higher than said threshold value. 3. A pressure transducer according to claim 2, and in which said diaphragm driving means comprise an electrical winding magnetically coupled to the diaphragm, and circuit means for producing in the winding a current that varies periodically in definite phase relation to the diaphragm oscillation. 4. A pressure transducer, comprising in combination a resilient diaphragm, structure for applying a fluid pressure differentially to the diaphragm to stress thesame transversely, means for driving the so stressed diaphragm to oscillate at its natural frequency, sensing means responsive to the diaphragm movement, means for developing clock pulses at a constant frequency higher than the frequency of diaphragm oscillation, means controlled by said sensing means for counting the clock pulses during a predetermined number of diaphragm oscillations and for offsetting the pulse count by the number of clock pulses that would occur during the same number of diaphragm oscillations at a predetermined reference pressure, and means responsive to the offset pulse count for indicating the excess of the applied pressure over the reference pressure.
Patent Citations
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State Rep Patricia Haynes in accident
State Representative, Patricia Haynes Smith was involved in a two car accident this morning. Smith, while traveling to her campaign office, was hit by another car that ran a stop sign.
The impact was severe enough that Smith had to be taken to the hospital, and her vehicle is likely totaled. She is currently being observed under doctor's care.
Representative Smith's campaign office is located at 2255 Highland Road, and she can be reached at (225)332-5556 for more information.


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July 5, 2011
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Turn any model into an relightable cloud and render it as a 32-bit HDR with this neat Maya plugin. Read more »
Featuring the new RIS raytracing architecture and costing just $495. Free version now due early 2015. Read more »
Check out Illuminated Tools' new set of free hi-res HDRIs. All are licensed for commercial use. Read more »
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GARCIA - Off the Beaten Path EP
Artist: Garcia
Twitter: Garcia on Twitter
Avg Rating: 4.4 ( 7 total votes )
Miami veteran GARCIA has come together with The DJBooth, Latchkey Recordings and Crazy Hood Productions to bring listeners his latest street release, the Off the Beaten Path EP.
The artist's fifth solo release, the project features nine original records from the rhymesayer who was first introduced to our readers on "Undercover" way back in October of 2008.
Joining GARCIA on the guest tip throughout Off the Beaten Path are Omniscient, AG Lyonz, Bernz and Wrekonize (of ¡MAYDAY! ), N.O.R.E. and REKS. Beats come courtesy of Big Drain, Miami Beat Wave, Dee Jay K-N-S, Hazardis Soundz and Davincci.
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McDonnell proposes teachers get conditional 2 percent raise
Gov. Bob McDonnell is proposing 2 percent pay raises for public school teachers conditioned on more strenuous teacher assessment standards and a longer probationary period for new hires.20 Comments
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Montgomery County parents petition to start school later
Parents in Montgomery County are ready to present the Board of Education a petition to start school later.
Georgetown to offer free online courses on edX
Georgetown University will begin offering free online courses through the same online education provider used by Harvard and MIT.Comment
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Robinson Secondary School Principal Dan Meier said in an email sent to parents that school administrators confiscated the gun.20 Comments
Education union pitches 'bar exam' for new teachers
The American Federation of Teachers called for a tough new written test to be complimented by stricter entrance requirements for teacher training programs, such as a minimum grade point average.11 Comments
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University of Iowa adds optional LGBT question to application
The University of Iowa announced Wednesday that its new application asks students whether they identify with the lesbian, gay, bi-sexual, transgender, queer community. The application also offers transgender as a gender option.7 Comments
UVA warned after Sullivan ouster attempt
The University of Virginia was put on warning Tuesday by an accrediting panel that examined the Board of Visitors' failed attempt to oust the prestigious public school's president this summer.5 Comments
Schools from 11 states, including D.C., win nearly $400M in grants
This year's version of President Barack Obama's Race to the Top competition let districts, rather than states, apply. The goal is to promote local solutions and personalized learning.Comment
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Francis-Stevens parents fight against school closure
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The numbers will tell the story
The numbers will tell the story in this year's NCAA Tournament. And Scoop breaks them down in style. Story
Updated: March 14, 2007, 1:57 PM ETBy Scoop Jackson | Page 2
The NCAA Tournament by the numbers:
$545 million: The amount of money CBS is spending this year for rights to broadcast the games we are about to be addicted to (the per-year average of its $6 billion, 11-year contract signed in 1999).
10 million: The number of people who will collectively scream in joy when VCU beats Duke.
$5 million: The money Pitt's Aaron Gray is going to lose over the weekend if he continues to play like he did in the Big East tournament.
1 million: ...
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Part of the art of acting lies in navigating the subtleties of and transitions between emotions. From scene to scene and moment to moment, an actress may find herself laughing, crying, shouting, whispering or … drunk singing?
Indeed, at least for Jennifer Aniston in the Daniel Barnz-directed drama "Cake," which finds her portraying a woman who becomes fascinated by the suicide of a member of her chronic-pain support group.
In this clip from the first episode of Epix and the Los Angeles Times' five-part series "Hollywood Sessions," Aniston talks about her "drunk and on-the-verge singing" scene.
"I wasn't actually supposed to sing along with it," Aniston recalls. "They did playback of it and it was Billy Joel's 'Honesty,' and so you couldn't help but do the stupid imitation of pretending to know the words, but you don't know the words." (Watch Aniston do just that in the video above.)
She adds, "We did have a lot of light moments, and that was definitely one of them."
Check back for more...Read more
For this year's awards season, The Envelope brought together a unique group of actresses, including rising stars breaking through to the next level and established stars breaking out into new roles and challenges, each earning some buzz for their current films.
Participating in the conversation were Jennifer Aniston from the small, personal drama "Cake" (opening in December); Emily Blunt from the musical "Into the Woods" (opening Christmas Day); Jessica Chastain from the recently released space epic "Interstellar" and the December drama "A Most Violent Year"; Gugu Mbatha-Raw from the historic drama "Belle," which opened in May; and Shailene Woodley from June's young adult love story "The Fault in Our Stars."
Here are edited excerpts from the free-flowing conversation moderated by Times film writers Rebecca Keegan and Mark Olsen in which the actresses share their experiences singing on-screen, drunk singing on-screen, what it takes to land a part and the changing roles for women in...Read more
Playing a slick attorney in "The Judge," Robert Downey Jr. traded Iron Man's armor for more tailored threads. The movie, which opened the Toronto International Film Festival in September, is a crowd-pleaser — funny, suspenseful and sometimes quite moving — anchored by a number of fine performances, particularly Downey and Robert Duvall, who play Hank and Judge Joseph Palmer, an estranged son and father working things out the hard way. We spoke to the actors, director David Dobkin and producer Susan Downey at a recent Envelope Screening Series event. Here are excerpts from the conversation.
The idea for this movie, David, started with your relationship with your mother and caring for her when she was sick. You had a complex relationship with her?
Dobkin: Very complicated. I was the kid always getting in trouble and getting arrested, and my father was the really brilliant attorney who was cross-examining me in the kitchen at night. But my mother somehow was the one that really delivered...Read more
With its turbulent swirls of black and gray, British painter J.M.W. Turner's 1842 canvas "Snow Storm — Steam-boat Off a Harbour's Mouth" is unparalleled in its evocation of the terror and beauty of a raging sea. There are those who doubt the story that Turner had himself strapped to a ship's mast during a gale in order to experience the forces he so vividly set down in paint, but actor Timothy Spall, who plays Turner in Mike Leigh's earthy biography, is not among them.
"There's a lot of contention among aficionados of Turner as to whether he did that," Spall agrees. "But when I look at that painting, having copied it full-size in oil, and having been in a Force 9 storm at sea as a skipper, I know he was definitely there, watching the storm. I know because of the movement in that painting, and the terror he captures, and the sense of isolation and the beauty. I just know that this is a man who knows about the sea."
In a dapper striped sport coat, Spall looks little like the snorting,...Read more
As Michael Keaton's critically lauded "Birdman" emerges as an Oscar hopeful, with its tortured actor losing sight of where his character ends and how much realism to bring to the stage, it calls to mind 1930s and '40s actor Ronald Colman.
The dashing, debonair Colman had been a major star since the silent era, making women's hearts flutter in his heroic, romantic roles in such films as 1935's "A Tale of Two Cities," 1937's "The Prisoner of Zenda" and 1942's "Random Harvest."
Colman finally got a chance to show a darker side in 1947's "A Double Life," a psychological thriller/film noir about a famous Broadway actor, Anthony John, who takes Method acting to a whole new and ultimately murderous level. Anthony is carefree and charming when he's doing a comedy but loses his grip on his sanity when he stars in Shakespeare's "Othello."
Nominated for four Academy Awards — including director for George Cukor and screenplay for Garson Kanin and his wife, Ruth Gordon — "A Double Life" won Oscars...Read more
My adaptation of "Gone Girl" began with a filthy, nasty amount of cursing. I really outdid myself. The [expletive] book was so [expletive] long and so [expletive] internal and so [expletive] unchronological … and what kind of [expletive] monster would write such a thing anyway? The answer to that last question was: me. I'd been cocksure certain I was the only person who should attempt to adapt my novel — it's me, it has got to be me! Then, when my bluff was called and it actually came time to write the script, I realized, to my horror, I might actually have to write the script.
I had a number of abandoned screenplays on my laptop (plied with enough booze, I may tell you someday about my romantic comedy involving animatronic pigs), so I understood the form. But "understanding the form" only takes you so far.
"Gone Girl" is a story about a golden couple, Nick and Amy Dunne. Amy goes missing on their five-year anniversary, Nick becomes a suspect — then stuff really starts to happen. "Gone...Read more


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doxorubicinLine breaks: doxo|rubi¦cin
Pronunciation: /ˌdɒksəʊˈruːbɪsɪn /
Definition of doxorubicin in English:
noun[mass noun] Medicine
A bacterial antibiotic that is widely used to treat leukaemia and various other forms of cancer.
- This is produced by the streptomycete bacterium Streptomyces peucetius caesius
Example sentences
- The patient was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy starting in August 1998.
- Cancer drugs used for primary bone cancer include methotrexate, doxorubicin, and cisplatin.
- Adjuvant therapy, multidrug chemotherapy was carried out with methotrexate, cyclophosphamide, doxorubicin, vincristine, and prednisone.
Definition of doxorubicin in:
- US English dictionary
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= trending
Word of the day Sprachgefühl
Pronunciation: ˈSHpräkɡəˌf(y)o͞ol
intuitive understanding of a language's natural idiom…


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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
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"Excellent quality! These turned out so well. I would definitely order these again, but for a different occasion this time. ;)"
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"Product was great and they arrived early! Style is perfect for modern event or if you want something simple yet classy. They had someone reword my notes that I put on the back of the card, i. e. registry information and who to send the RSVPs. Price is great too!"
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"Hey WWE I'm not trying to be rude but the crowd seems to really want Daniel Bryan. Juuuuuuust MAFAKIN Saying!! Geez. Sadly WWE is still run by 'Muscle Marks.' It is what it is folks."
- Shane Helms on backstage politics in WWE
"You're not allowed to get over in WWE unless they want you to. If you do, you can and will be punished. Has happened to many over the years."
- Armando Estrada on backstage politics in WWE
"Toronto deserves Rob Ford, they put him in office. Toronto deserves everything it gets. Up in Calgary we've got a more prestigious mayor [Naheed Nenshi]. I think we've got the best mayor in North America."
There are talks that TNA will be taking the tag team championship from Robbie E and Jessie Godderz soon. The feud involving Christopher Daniels, Frankie Kazarian, Eddie Edwards and Davey Richards is supposed to take center stage, and the belts will more than likely be used in that program.


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Beer yeast turned into cheap malaria drug in Gates-funded study
Anti-malarial medications save millions of lives, yet the supply of the sweet wormwood tree, the source of the most effective treatment, artemisinin, can fluctuate year to year, creating shortages.
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Baker's yeast, commonly used to make beer and bread, can be engineered to produce a key ingredient for malaria drugs, according to researchers who say the method offers a new way to boost needed supplies.
Anti-malarial medications save millions of lives, yet the supply of the sweet wormwood tree, the source of the most effective treatment, artemisinin, can fluctuate year to year, creating shortages. The study published Wednesday by the journal Nature, and funded by the Seattle-based Bill & Melinda Gates FoundationBill & Melinda Gates Foundation, describes how the new process boosts production of artemisinic acid by almost 16 times the amount of previous approaches.
"Prior to this, nobody had been able to get a high level production of artemisinin," Chris Paddon, a study author, said in an interview. "This is a big genetic engineering breakthrough."
READ MORE: Dinosaur embryos yield organic material in 'mind boggling' discovery by Canadian-led team
Paddon, principal scientist for Amyris Inc., an Emeryville, Calif.-based renewable chemicals and fuels company, said the intellectual property rights for the process described in the paper have been donated for nonprofit use in order to boost production.
The process resulted in 25 grams of commercially usable artemisinic acid concentration per litre, compared with previous methods that led to 1.6 grams per litre. Artemisinic acid is then converted into the drug artemisinin, which is combined with other anti-malarial treatments to ensure the parasites that cause the disease are cleared.
Sanofi, the Paris-based maker of Lantus insulin, will start using this method beginning tomorrow to produce semi-synthetic artemisinin, Paddon said.
Malaria kills a child in Africa every minute, according to the Geneva-based World Health Organization. The disease is spread through mosquitoes infected with the Plasmodium parasite, which multiply in the human liver, attacking red blood cells. It strikes about 216 million people each year and kills about 655,000.
"The key issue for the manufacture of these artemisinin combination therapies is that it's an agricultural product and so the prices vary hugely year to year, as does the supply," Roly Gosling, lead of the University of California, San Francisco's Global Health Group's Malaria Elimination Initiative, said in an interview. "This of course has a huge impact on public health programs."
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It's time for feathers and turkeys again! We have ideas for all your clients – whether they want...
Nail Art How To: Mother's Day
Pin this hashtag! A note telling Mom she's "#1!"
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Did you change this recipe up a little? We want to know! Share it with us by adding your special Twist.
Did you change this recipe?Add your Twist
A twist is a way to share your own spin on our recipies!
|6 boneless, skinless chicken-breast halves
|1 tablespoon soy sauce
|5 tablespoons olive oil
|1 teaspoon turmeric
|1 clove garlic
|Juice of 1 lime or lemon
|1 small onion, chopped &1 large onion, sliced
|1 to 3 hot chili peppers
|1-inch piece ginger root
|1 cup water
|1 cup unsalted roasted peanuts
Cut chicken into bite size pieces. Sauté chicken in 3 tablespoons olive oil until white and cooked through. Set aside.
Prepare satay sauce: Blend garlic, onion, ginger, peanuts, soy sauce, turmeric, lime or lemon juice, chili peppers, and water in blender or food processor until smooth. Place sauce in top of double boiler and heat water to boiling. Cover pot and cook sauce for 20 minutes or until thick. Sauté onion rings in remaining olive oil until soft. Pour satay sauce over chicken and stir until chicken is well coated. Stir in onion rings and serve over rice.
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Ratings based on 228 Verified Reviews
They paid and stayed. We double-checked.
4.4 Room cleanliness
4.3 Service & staff
4.4 Room comfort
4.2 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Everyoneby A verified travelerfrom syracuse ny
Always a great stayPosted Oct 15, 2014
The courtyards are a great place to stay. Always friendly and clean
for Everyoneby A verified traveler
Posted Oct 6, 2014
Good hotel polite and certious lots of activities in hotel
Recommendedby A verified traveler
Third time we've stayed here, it's a fine hotelPosted Aug 13, 2014 on Hotels.com
The area is fine, no sense of danger walking around or going to the nearby shopping plaza. The hotel itself had a remodeling in the lounge/lobby area, looks very nice! Liked the breakfast buffet they offered before, but the little breakfast stand was fine for what we needed. The elevator we used smelled like bug spray on Sunday morning, and they're probably the least up to date looking/feeling of everything in the hotel. Calling for a wake up call on Saturday night was futile, I called twice and let it ring for a long time thinking they may be busy checking someone in, but never did get anyone on the phone so we had to set the room clock and it's alarm. Not our preference when we're away from home, but it did the job. Everyone was very friendly in person though.
for Business Travelersby John R.from Kingston NY
Renaissance faire havenPosted Jul 8, 2014 on Hotels.com
My company sells at the Midsummer Fantasy Renaissance faire in Ansonia every year and this hotel was the "official" hotel for the event. My staff found the hotel to be very nice, clean, and efficient. It was a nice place to retreat to after a long hot day at faire!
for Personal Eventby A verified traveler
Posted Jul 1, 2014 on Hotels.com
Nice hotel , very clean.
Recommendedby Jay6630from Cleveland, OH
An Excellent Choice!Posted Jun 24, 2014 on Hotels.com
The room was far more spacious than I expected. The hotel was clean, orderly, and well appointed. The staff was courteous and attentive. I feel like I should have paid more than they charged. I will definitely stay there again when in the area!
for Overnight Stay Before Destinationby Carlfrom Houston
Clean and convenientPosted Jun 24, 2014 on Hotels.com
Nice rooms and location
Recommendedby A verified traveler
Posted Jun 20, 2014 on Hotels.com
for Everyoneby A verified travelerfrom CT
Good hotel in commercial area and close to hwyPosted Jun 18, 2014
Pros: Close to restaurants & hwy
Location: In commercial area with several other very similar hotels. Several choices of restaurants are available along with access to banking, office supplies
Stay was pleasant and pleasing. Room was clean and no loud disturbances. Staff was pleasant
for Everyoneby Nanfrom Albany, NY
REVIEW OF HOTELPosted Jun 17, 2014
Pros: Everything - The room was average size. Had fridge in room with a microwave.
Location: Grocery stores, shops, restaurants within walking distance.
Had an opportunity to stay at your hotel over past weekend with my daughter, her husband and granddaughter.. Very centrally located, near restaurants and shops. The hotel staff was awesome. My baby granddaughter had a bed wetting accident on the bed and I called down to front desk, within 5-10 minutes there was someone at our door with clean bedding. The pool was awesome, warm and clean. The rooms were very clean. Hotel was nice and updated. Loved the bar and the Bistro for dinner. Called for room service and within 15 minutes had my dinner brought to my room. Would definitely stay there again!


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Sparta Cabin Rental Photos and Description
Cabin, 2 Bedrooms + Den, 2 Baths, (Sleeps 4-8)
Enjoy privacy with your escape to the country and mountains. This cabin sets on a working Christmas Tree farm with a variety of wildlife. Enjoy the large porch areas with friends and family. Rent neighboring cabin, Fox Den #202460, for a family reunion.
Watch the extraordinary sunset and wait for the full moon to peek over the mountain. Fox Ridge is a place you soon won't forget.
Keywords: Mountain Cabin, spacious with long range views.
- Suitability:
- Events Allowed
- Long-term Renters Welcome
- children welcome
- non smoking only
- pets not allowed
About The Owner
Fox Ridge Mountain Cabin was initally named for Payton, whom you see to the left of his sister, Rylan. We will see Payton's place and Rylan's place in future rental ads.
The Owner purchased this cabin in 2008
Why The Owner chose Sparta
Because of the natural beauty and contour of the mountains and farmlands. I was raised in the mountains and love the diversity of the seasons.
What makes this cabin unique
Peacefulness, away from the city hustle and bustle.


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This short with Alan Rickman just destroyed one of my childhood memories
I don't know if the short Dust—written and directed by Ben Ockrent and Jake Russell—is a fairy tale or a horror tale. Let's just say that I didn't expect the end at all. This is very disturbing but worth watching, and not only because I love Alan Rickman in the role of... of... you just watch and see. »


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FRIDAY, March 9 (HealthDay News) -- Oral anticoagulation (OAC)-treated patients with high levels of von Willebrand factor (VWF) have elevated risks of bleeding complications and cardiovascular and all-cause mortality, according to a study published in the March issue of the Journal of Internal Medicine.
Marcus Lind, M.D., of Umeå University Hospital in Sweden, and associates conducted a longitudinal study of 719 patients receiving OAC treatment to evaluate the link between VWF plasma levels and risk of bleeding complications, cardiovascular death, and all-cause mortality.
During 4.2 years of follow-up, the researchers identified 113 cases of clinically relevant bleeding and 73 cases of major bleeding; and there were 161 deaths, including 110 attributed to cardiovascular disease. There was a significantly increased risk of bleeding complications for patients in the highest tertile of VWF (hazard ratio [HR] for major bleeding, 2.53; HR for clinically relevant bleeding, 2.19). VWF was significantly associated with cardiovascular and all-cause mortality (HR, 1.68 and 1.77, respectively). These findings were significant after adjusting for age, high-sensitivity C-reactive protein, and creatinine.
"Our findings imply that the use of VWF as a risk marker for thromboembolic events is complicated by the association of VWF with bleeding complications," the authors write.
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November 4, 2014: A look at Justin's favourite recent wintertime rides for maximum confidence Read Article
September 18, 2014: Infiniti's QX70S is a fun-to-drive and surprisingly practical machine that continues to be competitive in the face of newer offerings from competitors. Read Article
September 8, 2014: Sometimes a long-wheelbase car is just a long-wheelbase car. Read Article
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May 12, 2014: Three different powertrain types, two seating configurations and seven separate luxury SUVs battle it out in an epic Luxury SUV comparison test. Read Article
March 24, 2014: Infiniti's Q50 Hybrid combines efficient power and mischievous dynamics in a must-drive performance sedan. Read Article
March 6, 2014: Infiniti's hybridized family hauler offers a reasonable dose of extra efficiency and a great big helping of additional standard equipment. Read Article
February 13, 2014: Resident engineering expert Haney Louka breaks down AJAC's choices for Best New Technology awards for 2014. Read Article