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Publications (93)165.52 Total impact
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ABSTRACT: Receiver operating characteristic (ROC) research has been limited to binary choice. Recently, the method was generalized based on the Lehmann assumption also known as the proportional hazards specification. This model accommodates a variety of research questions such as covariate adjustments. By applying this method to three-class ROC analysis, simple analytical forms of ROC surface and volume under the surface were derived without and with covariates. Furthermore, the model parameters and the corresponding asymptotic variances were evaluated. Simulation studies were performed to assess the validity of our proposed method in finite samples and extension work for dimension higher than three-class is considered.Journal of Statistical Computation and Simulation 02/2015; 85(3). · 0.63 Impact Factor
- Annales de Dermatologie et de Vénéréologie 11/2014; · 0.60 Impact Factor
Article: Significant heterogeneity in the geographical distribution of diffuse grade II/III gliomas in France.[Show abstract] [Hide abstract]
ABSTRACT: Diffuse WHO grade II and III gliomas (DGII/IIIG) are rare tumors, with few specific epidemiological studies. We aimed at describing the geographical distribution of a homogeneous series of histologically confirmed DGII/IIIG, over a four-year period (2006-2009), at a national level. The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase and data collected directly from every neuropathology department. Personal home addresses were collected for confirmed cases. For each region, the incidence of DGII/IIIG was analyzed and standardized on the age and sex distribution of the French population. The number of patients with newly diagnosed, histologically confirmed DGII/IIIG was 4,790. The overall crude rate was 19.4/10(6). To enable international comparisons, standardized rates were calculated as follows: 19.8/10(6), 18.8/10(6) and 16.0/10(6) (reference population, Europe, US and world, respectively). The geographical distribution by region showed significant differences, with higher incidence rates in Northeast and central parts of France. This work is the first studying the geographical distribution of a pure series of DGII/IIIG at a national level. It demonstrates significant heterogeneity in the distribution, and raises the question of the role of environmental and/or genetic risk(s) factor(s) for DGII/IIIG.Journal of Neuro-Oncology 08/2014; · 3.12 Impact Factor
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ABSTRACT: The objective of this work was to detail the incidence and mortality trends of invasive and in situ breast cancer (BC) in France, especially regarding the development of screening, over the 1990-2008 period. Data issued from nine population-based cancer registries were studied. The incidence of invasive BC increased annually by 0.8 % from 1990 to 1996 and more markedly by 3.2 % from 1996 to 2003, and then sharply decreased until 2006 (-2.3 % per year), especially among women aged 50-69 years (-4.9 % per year). This trend was similar whatever the introduction date of the organized screening (OS) program in the different areas. The incidence of ductal carcinoma in situ steadily increased between 1990 and 2005, particularly among women aged 50-69 years and 70 and older. At the same time, the mortality from BC decreased annually by 1.1 % over the entire study period. This decrease was more pronounced in women aged 40-49 and 50-69 and, during the 1990-1999 period, in the areas where OS began in 1989-1991. The similarity in the incidence trends for all periods of implementation of OS in the different areas was striking. This suggests that OS alone does not explain the changes observed in incidence rate. Our study highlights the importance of closely monitoring the changes in incidence and mortality indicators, and of better understanding the factors causing variation.Breast Cancer Research and Treatment 08/2014; · 4.47 Impact Factor
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ABSTRACT: The aim of this study was to draw a picture of diagnostic assessment and patterns of care for rectal cancer in France using population-based registries data. The study included a random sample of 669 cases of rectal cancers diagnosed in 2005. Diagnostic assessment was performed by colonoscopy in 91.4% of the cases. An abdominal computed tomography was performed in 59.4% of the cases and chest computed tomography in 47.8%. An R0 resection was performed in 65.8% of cases and an R1/R2 resection in 16.1%. A rectal endosocography was performed in 40.4% and MRI in 10.4%. The sphincter was preserved in 73.6% of patients aged younger than 75 years of age and in 62.5% of those older than 75 years of age (P=0.002). In cases of R0 resection, neoadjuvant radiotherapy was performed in 47.8% of patients younger than 75 years of age and in 34.1% of older patients (P=0.007). Postoperative chemotherapy was administered in 23.9% of stage II and 67.8% of stage III resected patients. The management of rectal cancers can be improved. Preoperative staging has not reached its full development; very few patients received neoadjuvant treatment, whereas adjuvant chemotherapy was often performed, although its benefit is still unclear. The management of elderly patients was less optimal than that of younger patients.European journal of gastroenterology & hepatology 05/2014; · 1.66 Impact Factor
Article: Management of rectal cancers in relation to treatment guidelines: a population-based study comparing Italian and French patients.[Show abstract] [Hide abstract]
ABSTRACT: Few studies have investigated rectal cancer management at the population level. We compared how rectal cancers diagnosed in Italy (2003-2005) and France (2005) were managed, and evaluated the extent to which management adhered to European guidelines. Samples of 3938 Italian and 2287 French colorectal cancer patients were randomly extracted from 8 and 12 cancer registries respectively. Rectal cancer patients (860 Italian, 559 French) were analysed. Logistic regression models estimated odds ratios (ORs) of being treated with curative intent, receiving sphincter-saving surgery, and receiving preoperative radiotherapy. Similar proportions of Italian and French patients were treated with curative intent (70% vs. 67%; OR=0.92 [0.73-1.16]); the respective proportions receiving sphincter-saving surgery were 21% and 33% (OR=1.15 [0.86-1.53]). In about 50% of those treated with curative intent, ≥12 lymph nodes were harvested in both countries. The proportion receiving postoperative radiotherapy was higher in Italy than in France (25% vs. 11%, p<0.01), but French patients were more likely to receive preoperative radiotherapy (52% vs. 21%; OR=4.06 [2.79-5.91]). The proportions of patients receiving preoperative radiotherapy and the numbers of lymph nodes sampled were low in both countries. Centralising treatment and potentiating screening would be practical ways of improving outcomes and adhering to guidelines.Digestive and Liver Disease 04/2014; · 3.16 Impact Factor
Article: Epidemiological study of prostate cancer (EPICAP): a population-based case-control study in France.[Show abstract] [Hide abstract]
ABSTRACT: Prostate cancer is the most common cancer in male in most Western countries, including France. Despite a significant morbidity and mortality to a lesser extent, the etiology of prostate cancer remains largely unknown. Indeed, the only well-established risk factors to date are age, ethnicity and a family history of prostate cancer. We present, here, the rationale and design of the EPIdemiological study of Prostate CAncer (EPICAP), a population-based case-control study specifically designed to investigate the role of environmental and genetic factors in prostate cancer. The EPICAP study will particularly focused on the role of circadian disruption, chronic inflammation, hormonal and metabolic factors in the occurrence of prostate cancer. EPICAP is a population-based case-control study conducted in the departement of Herault in France. Eligible cases are all cases of prostate cancers newly diagnosed in 2012-2013 in men less than 75 years old and residing in the departement of Herault at the time of diagnosis. Controls are men of the same age as the cases and living in the departement of Herault, recruited in the general population.The sample will include a total of 1000 incident cases of prostate cancer and 1000 population-based controls over a 3-year period (2012-2014).The cases and controls are face-to-face interviewed using a standardized computed assisted questionnaire. The questions focus primarily on usual socio-demographic characteristics, personal and family medical history, lifestyle, leisure activities, residential and occupational history. Anthropometric measures and biological samples are also collected for cases and controls. The EPICAP study aims to answer key questions in prostate cancer etiology: (1) role of circadian disruption through the study of working hours, chronotype and duration/quality of sleep, (2) role of chronic inflammation and anti-inflammatory drugs, (3) role of hormonal and metabolic factors through a detailed questionnaire, (4) role of individual genetic susceptibility of genes involved in biological pathways of interest. The EPICAP study will also allow us to study prognostic factors and tumor aggressiveness.Taken together, the EPICAP study will provide a comprehensive framework to go further in the understanding of prostate cancer occurrence and its prognosis.BMC Cancer 02/2014; 14(1):106. · 3.33 Impact Factor
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ABSTRACT: Although cancer survivors are known to be at greater risk of developing second primary cancer (SPC), SPC incidence estimates in France are thus far lacking. We used a multivariate approach to compute these estimates and analyzed the effect of patient characteristics (gender, age at diagnosis, first cancer site, year of diagnosis and follow-up) on SPC risk. Data from ten French population-based cancer registries were used to establish a cohort of all patients diagnosed with a first cancer between 1989 and 2004 and followed up until December 31, 2007. The person-year approach was used to estimate standardized incidence ratios (SIRs) and excess absolute risks (EARs) of metachronous SPC. Multivariate Poisson regression models were then used to model SIRs and EARs separately by gender, adjusting for age, year of diagnosis, follow-up and first cancer site. Among the 289,967 followed-up patients with a first primary cancer, 21,226 developed a SPC. The SIR was of 1.36 (95% CI, 1.35-1.38) and the EAR was of 39.4 excess cancers per 10,000 person-years (95% CI, 37.4-41.3). Among male and female patients, multivariate analyses showed that age, year of diagnosis, follow-up and first cancer site were often independently associated with SIRs and EARs. Moreover, the EAR of SPC remained elevated during patient follow-up. French cancer survivors face a dramatically increased risk of SPC which is probably related to the high rate of tobacco and alcohol consumption in France. Multivariate modeling of SPC risk will facilitate the construction of a tailored prediction tool to optimize SPC prevention and early detection strategies.BMC Cancer 02/2014; 14(1):94. · 3.33 Impact Factor
Article: Oncological patterns of care and outcomes for 265 elderly patients with newly diagnosed glioblastoma in France.[Show abstract] [Hide abstract]
ABSTRACT: The incidence of glioblastoma (GBM) has increased in patients aged 70 years or older, and will continue to grow. Elderly GBM patients have been excluded from most clinical trials; furthermore, optimal care management as well as benefit/risk ratio of GBM treatments are still being debated. This study describes oncological patterns of care, prognostic factors, and survival for patients ≥70 years in France. We identified patients over 70 with newly diagnosed and histologically confirmed GBM on data previously published by the French Brain Tumor DataBase. We included 265 patients. Neurological deficits and mental status disorders were the most frequent symptoms. The surgery consisted of resection (RS n = 95) or biopsy (B n = 170); 98 patients did not have subsequent oncological treatment. After surgery, first-line treatment consisted of radiotherapy (RT n = 76), chemotherapy (CT n = 52), and concomitant radiochemotherapy (CRC n = 39). The median age at diagnosis was 76, 74, and 73 years, respectively, for the untreated, B + RT and/or CT, RS ± RT and/or CT groups. Median survival (in days, 95 % CI) with these main strategies, when analyzed according to surgical groups, was: B-CT n = 41, 199[155-280]; B-CRC n = 21, 318[166-480]; B-RT n = 37, 149[130-214]; RS-CT n = 11, 245[211-na]; RS-CRC n = 18, 372[349-593]; RS-RT n = 39, 269[218-343]. This population study for elderly GBM patients is one of the most important in Europe, and could be considered as a historical cohort to compare future treatments. Moreover, we can hypothesize that elderly patients (versus patients <70 years) are undertreated. Karnofsky performance status seems to be the most relevant clinical predictive factor, and RS and CRC have a positive impact on survival for elderly GBM patients in the general population, at least when feasible.Neurosurgical Review 02/2014; · 1.97 Impact Factor
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ABSTRACT: Background:Whether women are more or equally susceptible to the carcinogenic effects of cigarette smoke on the lungs compared with men is a matter of controversy. Using a large French population-based case-control study, we compared the lung cancer risk associated with cigarette smoking by gender.Methods:The study included 2276 male and 650 female cases and 2780 male and 775 female controls. Lifetime smoking exposure was represented by the comprehensive smoking index (CSI), which combines the duration, intensity and time since cessation of smoking habits. The analysis was conducted among the ever smokers. All of the models were adjusted for age, department (a regional administrative unit), education and occupational exposures.Results:Overall, we found that the lung cancer risk was similar among men and women. However, we found that women had a two-fold greater risk associated with a one-unit increase in CSI than men of developing either small cell carcinoma (OR=15.9, 95% confidence interval (95% CI) 7.6, 33.3 and 6.6, 95% CI 5.1, 8.5, respectively; P<0.05) or squamous cell carcinoma (OR=13.1, 95% CI 6.3, 27.3 and 6.1, 95% CI 5.0, 7.3, respectively; P<0.05). The association was similar between men and women for adenocarcinoma.Conclusion:Our findings suggest that heavy smoking might confer to women a higher risk of lung cancer as compared with men.British Journal of Cancer advance online publication, 14 January 2014; doi:10.1038/bjc.2013.821 www.bjcancer.com.British Journal of Cancer 01/2014; · 5.08 Impact Factor
Article: Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France. We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case--control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking. Personal history of oral candidiasis was related to a significantly increased risk of oral cavity cancer (OR 5.0, 95% CI 2.1-12.1). History of head and neck cancers among the first-degree relatives was associated with an OR of 1.9 (95% CI 1.2-2.8). The risk increased with the number of first-degree relatives with head and neck cancer. A family history of head and neck cancer is a marker of an increased risk of oral cavity cancer and should be taken into account to target prevention efforts and screening. Further studies are needed to clarify the association between oral cavity cancer and personal history of candidiasis.BMC Cancer 11/2013; 13(1):560. · 3.33 Impact Factor
Article: Trends in incidence of breast cancer among women under 40 in seven European countries: A GRELL cooperative study.[Show abstract] [Hide abstract]
ABSTRACT: Young women are not usually screened for breast cancer (BC). The trends in incidence in this population may better reflect changes in risk factors. However, studies on this subject are scarce and heterogeneous. The aim of this study was to describe the trends in incidence of BC in women under 40 from 1990 to 2008, using pooled European data. Thirty-seven European population-based cancer registries from Belgium, Bulgaria, France, Italy, Portugal, Spain and Switzerland participated in this study. World age-standardized incidence rates were first analyzed graphically and then using a Poisson regression model, in order to estimate average annual percent changes (AAPCs). The overall incidence rate of BC in the area covered increased linearly during the study period by 1.19% (0.93; 1.46) on average per year. This increase varied between countries from 0.20% (-0.53; 0.64) in Bulgaria to 2.68% (1.97; 3.40) in Portugal. In Italy, after a significant rise of 2.33% (1.14; 3.54) per year, BC incidence began decreasing in 2002 by -2.30% (-4.07; -0.50) yearly. The rise in incidence was greater for women under 35 and for ductal carcinomas. This increase can be due to a rise in risk factors and/or changes in diagnosis and surveillance practices, but we could not clearly distinguish between these two non-exclusive explanations.Cancer epidemiology. 06/2013;
Article: Consistency and inconsistency in testing biomarkers in breast cancer. A GRELL study in cut-off variability in the Romance language countries.[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: Biological markers are crucial factors in order to differentiate female breast cancers and to determine the right therapy. This study aims at evaluating whether testing for biomarkers for female breast cancer has similar frequency and characteristics across and within countries. METHODS: Population-based cancer registries of the Association for cancer registration and epidemiology in Romance language countries (GRELL) were asked to complete a questionnaire on biomarkers testing. The data collected referred to invasive female breast cancer cases diagnosed between 2004 and 2009. The investigation focused on 1) the overexpression and amplification of the human epidermal growth factor receptor 2 oncogene (HER2); 2) the expression of oestrogen (ER) and progesterone (PgR) receptors; and 3) the proliferation index (PI). Weighted percentages, the heterogeneity among and within countries, and the correlation between responses and calendar years were evaluated. The study was based on 19,644 breast cancers. RESULTS: Overall, 85.9% of the cases were tested for HER2, 91.8% for both ER and PgR, and 74.1% for proliferative markers. For HER2 and ER-PgR, the frequency of testing increased from 2004 to 2009. Testing varied among countries (HER2 from 82.0% to 95.9%, ER-PgR from 89.3% to 98.9%, PI from 10% to 92%) and also within the same country (e.g. HER2 in Italy from 51% to 99%) as well as within single cancer registries. The most relevant differences were in the scores for positive/negative/not clearly defined HER2 (e.g. HER2 was defined positive if IHC 3+ in 21/33 registries), and in the cut-off of positive cells for ER/PgR (from >0% to >30%) and PI positivity (from >0% to >20%). CONCLUSIONS: Biological markers are widely tested in the Romance language countries; however, the parameters defining their positivity may vary, raising concerns about homogeneity in breast cancer classification and treatment.Breast (Edinburgh, Scotland) 05/2013; · 2.09 Impact Factor
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ABSTRACT: Objective: To estimate the magnitude of over-diagnosis and of potential and actual over-treatment regarding prostate cancer, taking comorbidities into account. Materials and methods: We used a sample collected by the French cancer registries of 1840 cases (T1: 583; T2: 1257) diagnosed in 2001. The proportion of over-diagnosed and over-treated patients was estimated by comparing life expectancy (LE), including or not comorbidities, with natural LE with cancer, using several assumptions from the literature. We distinguished potential and actual over-treatment according to the treatment that patients actually received. Results: Among patients with T1 tumors the proportion of potential over-treatment using LE adjusted for comorbidity varied from 29.5% to 53.5%, using LE adjusted on comorbidities, and varied from 9.3% to 22.2% regarding actual over-treatment. Between 7.7% and 24.4% of patient's receiving a radical prostatectomy, and between 30.8% and 62.5% of those receiving radiotherapy, were over-treated. Among patients with T2 tumors, the proportions of potential and actual over-treatment were 0.9% and 2.0%. Two per cent of patients receiving a radical prostatectomy and 4.9% of those receiving radiotherapy were over-treated. Comorbidities dramatically increased these proportions to nearly 100% of patients, with more than two comorbidities being potentially over-treated and around 33% actually over-treated. Conclusions: According to the French incidence, 3200-4800 French patients may be over-treated, among whom a large proportion of patients had comorbidities. The real issue is to offer the most appropriate treatment to people with low-grade tumors and comorbidities.Cancer epidemiology. 04/2013;
Article: Waiting time disparities in breast cancer diagnosis and treatment: A population-based study in France.[Show abstract] [Hide abstract]
ABSTRACT: Waiting times are key indicators of a health's system performance, but are not routinely available in France. We studied waiting times for diagnosis and treatment according to patients' characteristics, tumours' characteristics and medical management options in a sample of 1494 breast cancers recorded in population-based registries. The median waiting time from the first imaging detection to the treatment initiation was 34 days. Older age, co-morbidity, smaller size of tumour, detection by organised screening, biopsy, increasing number of specimens removed, multidisciplinary consulting meetings and surgery as initial treatment were related to increased waiting times in multivariate models. Many of these factors were related to good practices guidelines. However, the strong influence of organised screening programme and the disparity of waiting times according to geographical areas were of concern. Better scheduling of diagnostic tests and treatment propositions should improve waiting times in the management of breast cancer in France.Breast (Edinburgh, Scotland) 03/2013; · 2.09 Impact Factor
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ABSTRACT: This study aimed to describe cancer incidence (2000-2008) and survival (2000-2004) in France in adolescents and young adults (AYA). All cases of cancer diagnosed in 15-24 years, recorded by all French population-based registries (14% of the French population), over the 2000-2008 period, were included. Incidence change over time was described with the conventional annual percentage change (cAPC). The survival of cases diagnosed (2000-2004) was estimated using Kaplan-Meier method. A total of 1022 in adolescents and 1396 in young adults were diagnosed. Overall incidence rates were 219.4/10(6) in 15-19 year olds and 293.1/10(6) in 20-24 year olds. The most frequently diagnosed cancers in male AYA were malignant gonadal germ-cell tumors and Hodgkin's disease, and were melanoma, thyroid carcinoma, and Hodgkin's disease in females. The age-standardized rates appeared stable over time in AYA, with a cAPC of +2.0% (P = 0.68). The 5-year overall survival for all cancers was different between genders and age groups, with 78.8% (95%CI: 75.6-82.0) for males and 85.2% (95%CI: 82.2-88.1) for females (P = 0.01), and 78.5% (95%CI: 75.0-82.1) in 15-19 year olds and 84.3% (95% CI: 81.6-87.0) in 20-24 year olds (P = 0.02). Noteworthy, the frequency and the distribution of tumor types in AYA are unique and different from the observed at any other age group. Survival in French AYA has improved over time. Epidemiological data might reflect major trends in the risk factors and preventive interventions. Thus, further research into etiology of cancers affecting AYA should become key priorities for cancer control among AYA.Pediatric Hematology and Oncology 01/2013; · 0.90 Impact Factor
Article: Unbiased estimates of long-term net survival of haematological malignancy patients detailed by major subtypes in France.[Show abstract] [Hide abstract]
ABSTRACT: Long-term population-based survival data detailed by cancer subtype are important to measure the overall outcomes of malignancy managements. We provide net survival estimates at 1, 3, 5, and 10 years post-diagnosis on 37,549 haematological malignancy (HM) patients over 15 years old diagnosed between 1989 and 2004 and actively followed until 2008 by French population-based cancer registries. These are, to our knowledge, the first unbiased estimates of ten-year net survival in HMs detailed by subtypes. HMs were classified according to the International Classification of Diseases-Oncology-3. Net survival was estimated with the unbiased Pohar-Perme method. The results are reported by sex and age-classes. The changes of these indicators by periods of diagnosis were tabulated and the trends of the net mortality rates over time since diagnosis graphed. Five and 10-year age-standardized net survivals after HMs varied widely from 81% and 76% for classic Hodgkin lymphoma (CHL) to 18% and 14% for acute myeloid leukaemia (AML). Even in HMs with the most favourable prognoses, the net survival decreased between 5 and 10 years post-diagnosis. Women had better prognoses than men and age at diagnosis was an unfavourable prognostic factor for most HMs. In patients less than 55 years old, the net mortality rate decreased to null values five years post-diagnosis in AML and ten years post-diagnosis in CHL, precursor non-Hodgkin lymphoma, chronic myelogenous leukaemia, diffuse large B-cell lymphoma, and follicular lymphoma. The prognoses improved for various HMs over the study period. The obtained unbiased indicators are important to evaluate national cancer plans.International Journal of Cancer 10/2012; · 6.20 Impact Factor
Article: Identification of dietary patterns using two statistical approaches and their association with breast cancer risk: a case-control study in Southern France.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this case-control study was to compare two different statistical methods in the identification of dietary patterns by use of principal component analysis (PCA) and variable clustering (VC) and to examine their association with the risk of breast cancer (BC). A dose-response association was then performed by the use of an adaptation of free knot spline function in logistic models. A "Western" pattern was revealed by PCA and VC and was then shown to be associated with a nonsignificant increase of BC risk. Only PCA identified a "meat/alcohol" pattern. Above the spline threshold, BC risk increased significantly (OR ≥ s vs. < s = 2.56, 95% CI 1.54-4.27). When we used PCA, a "Mediterranean" pattern was identified, but no association between BC risk and this pattern was shown. VC split the "Mediterranean" dietary pattern in two: "raw vegetables and olive oil" and "fish." Above the spline threshold, the "fish" pattern tended to protect against BC risk (OR ≥ s vs. < s = 0.77, 95% CI 0.58-1.01), whereas an excess of raw vegetables and olive oil increased BC risk (OR 1 se = 1.22, 95% CI = 1.06-1.32). Some results from the PCA and the VC methods were similar, whereas others were different but gave complementary results.Annals of epidemiology 05/2012; 22(7):499-510. · 2.95 Impact Factor
Article: [French brain tumor database: general results on 40,000 cases, main current applications and future prospects].[Show abstract] [Hide abstract]
ABSTRACT: This work aimed at prospectively record all primary central nervous system tumor (PCNST) cases in France, for which histological diagnosis was available. The objectives were to (i) create a national database and network to perform epidemiological studies, (ii) implement clinical and basic research protocols, and (iii) harmonize the health care of patients affected by PCNST. The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase (FBTDB) (Recensement national histologique des tumeurs primitives du système nerveux central [RnhTPSNC]), and the active participation of the Scientific Societies involved in neuro-oncology in France. From 2004 to 2009, 43,929 cases of newly diagnosed and histologically confirmed PCNST have been recorded. Histological diagnoses included gliomas (42,4%), all other neuroepithelial tumors (4,4%), tumors of the meninges (32,3%), nerve sheath tumors (9,2%), lymphomas (3,4%) and others (8,3%). Cryopreservation was reported for 9603 PCNST specimens. Tumor resections were performed in 78% cases, while biopsies accounted for 22%. Median age at diagnosis, sex, percentage of resections and number of cryopreserved tumors were detailed for each histology, according to the WHO classification. Many current applications and perspectives for the FBTDB are illustrated in the discussion. To our knowledge, this work is the first database in Europe, dedicated to PCNST, including clinical, surgical and histological data (with also cryopreservation of the specimens), and which may have major epidemiological, clinical and research implications.Neurochirurgie 02/2012; 58(1):4-13. · 0.32 Impact Factor
Article: Recensement national histologique des tumeurs primitives du système nerveux central : résultats généraux sur 40 000 cas, principales applications actuelles et perspectives[Show abstract] [Hide abstract]
ABSTRACT: Background and purposeThis work aimed at prospectively record all primary central nervous system tumor (PCNST) cases in France, for which histological diagnosis was available. The objectives were to (i) create a national database and network to perform epidemiological studies, (ii) implement clinical and basic research protocols, and (iii) harmonize the health care of patients affected by PCNST.Methods The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase (FBTDB) (Recensement national histologique des tumeurs primitives du système nerveux central [RnhTPSNC]), and the active participation of the Scientific Societies involved in neuro-oncology in France.ResultsFrom 2004 to 2009, 43,929 cases of newly diagnosed and histologically confirmed PCNST have been recorded. Histological diagnoses included gliomas (42,4%), all other neuroepithelial tumors (4,4%), tumors of the meninges (32,3%), nerve sheath tumors (9,2%), lymphomas (3,4%) and others (8,3%). Cryopreservation was reported for 9603 PCNST specimens. Tumor resections were performed in 78% cases, while biopsies accounted for 22%. Median age at diagnosis, sex, percentage of resections and number of cryopreserved tumors were detailed for each histology, according to the WHO classification.Discussion/conclusionMany current applications and perspectives for the FBTDB are illustrated in the discussion. To our knowledge, this work is the first database in Europe, dedicated to PCNST, including clinical, surgical and histological data (with also cryopreservation of the specimens), and which may have major epidemiological, clinical and research implications.RésuméObjectifCe travail a pour objectif de recenser de manière prospective l'ensemble des cas de tumeurs primitives du système nerveux central (TPSNC), ayant un diagnostic histologique, en France. Les buts sont de créer une base de données et un réseau national pour favoriser la mise en place d'études épidémiologiques, biologiques et cliniques, et d'harmoniser la prise en charge des patients atteints de TPSNC.MéthodeLa méthodologie est basée sur l'existence d'un réseau national multidisciplinaire déjà établi par le Recensement national histologique des tumeurs primitives du système nerveux central (RnhTPSNC) (French Brain Tumor DataBase [FBTDB]), et la participation active des sociétés savantes impliquées en neuro-oncologie.RésultatsDe 2004 à 2009, 43 929 cas incidents de TPSNC ayant une confirmation histologique ont été recensés : gliomes (42,4 %), ensemble des autres tumeurs neuroépithéliales (4,4 %), tumeurs des méninges (32,3 %), tumeurs des nerfs intracrâniens et/ou intrarachidiens (9,2 %), lymphomes (3,4 %), et autres (8,3 %). La cryopréservation a été notée pour 9603 cas de TPSNC. Une intervention d'exérèse a été réalisée dans 78 % des cas, et une biopsie dans 22 %. L'âge médian au diagnostic, le sexe, le pourcentage de tumeurs réséquées, et le nombre de cas cryopréservés sont détaillés pour chaque histologie.Discussion/conclusionLes principales applications actuelles et futures du RnhTPSNC sont présentées dans la discussion. À notre connaissance, ce travail constitue la première base de données en Europe, dédiée aux TPSNC, qui recense des données cliniques, chirurgicales et histologiques (incluant la cryopréservation), et ses applications et perspectives sont très nombreuses.Neurochirurgie. 02/2012; 58(1):4–13.
Top Journals
Centre Hospitalier Universitaire de NantesNaoned, Pays de la Loire, France
Centre Hospitalier Universitaire de MontpellierMontpelhièr, Languedoc-Roussillon, France
Centre Hospitalier Régional Universitaire de NîmesNismes, Languedoc-Roussillon, France
University of BurgundyDijon, Bourgogne, France
Hospices Civils de LyonLyons, Rhône-Alpes, France
Centre Hospitalier Universitaire de NancyNancy, Lorraine, France
Centre Hospitalier Universitaire de GrenobleGrenoble, Rhône-Alpes, France
Institut du Cancer de Montpellier Val d'AurelleMontpelhièr, Languedoc-Roussillon, France


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Although Salt Lake City doesn't yet have a strong boxing culture, the introduction of this youth enrichment program might be the beginning of a tradition. Promise South Salt Lake – an initiative to invigorate that community has made promises for the success and well-being of local children, and the PAL boxing program provides structure, discipline, and encouragement for those who need it most.
November 20, 2014
All Ages Bluegrass Jam
Wasatch Musician, 648 E Union Square, Sandy
November 20, 2014
Jammy Time at the Murray Library
Murray Public Library, 166 E 5300 S, Murray

subset: commoncrawl


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Christina Santiago is Playboy's Miss August 2002 and Playmate of the Year 2003. If you watched Fox's Girl Next Door: The Search for a Playboy Centerfold, you know that Christina was one of three finalists. "I wasn't a sore loser when I lost to Lauren Anderson, but I was disappointed because I didn't understand what Playboy was looking for in a Playmate," she said. "When I got the phone call saying I was going to be Miss August, I had to eat my words."
The Chicago native's striking features helped her become a professional model, but she doesn't think she had an advantage over the other 11 women. "I'd never done nude modeling before," she said. "I didn't feel uncomfortable, because I'm content with my body, and I'm not afraid to show it."
She was even less shy around the cameramen recording her every move for two weeks. Much of the footage was deemed too hot for television. "We couldn't talk to the crew at all," she said. "The only thing that we could do when the cameramen left the room, which was probably mean on our part, was to purposely do something outrageous so they'd run back to the room trying to get to their cameras. I made out with this girl on the show, but I don't think you see that on network TV."
So all signs point to the contestants' getting along, right? "Everyone thought there would be catfights. But the contract specifically said, 'No pulling hair, no spitting, no biting,'" she said. "I was laughing so hard!"
Christina's experience with Playboy and meeting Hugh Hefner only encouraged her more. "Hef knows I'm a strong person and sees potential in me," she said at the time. "He's willing to give me the chance that no one else has given me. In the next five years, I hope to audition for a big movie, soap opera, or sitcom. I'd like to be a choreographer and would love to be onstage for the Oscars or Grammys performing with Jennifer Lopez or something. I try to do the right things in life. Whenever a good opportunity has knocked on my door, I've always tried to make the most of it."
Some of the opportunities Christina has made the most of include competing on Family Feud's "Playboy Playmates vs. Bachelors" special and acting in the short film A Tale of Two Sisters. In 2007 she was featured in the music video for The Dream's "Shawty Is a 10."
When she posed for Playboy Christina revealed what she's looking for in Mr. Right. "Why would I want men going through my life, in and out?" she asked. "I want just one. I'm attracted to guys who are older than 26, over six feet tall, with a nice ass. I'm a butt girl, so I like a guy who has a nice body and takes good care of himself. He doesn't have to be cut, just not fat, okay? I would love it if a guy would take me out to karaoke on a first date, because that would show how open-minded and courageous he is. I can always feel the vibe right away if there's the potential to date someone seriously. In the near future, I see myself with my man in our house, being very happy."


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Bridgetown, Barbados - Defending Sagicor General Twenty20 champions Sagicor Life UWI bounced out Republic Bank St Catherineby 28 runs to booka place in today's final against CGI Maple.
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Gondry's Mood Indigo Gets Richer as It Darkens
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Land Ho!'s Horny Seniors Never Quite Charm
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And the Sea Took Us. Marwella is a tiny fishing community on the southern coast of Sri Lanka, and there's nothing very special about it. It is only one of the hundreds of villages destroyed by the Indian Ocean tsunamis of December 26, 2004. On that day, the town lost all of its industry, most of its buildings, and a quarter of its population. Outside help was needed. That's why William Prosser was able to make his movie. And the Sea Took Uswas not supposed be a real documentary. Prosser is a surrealist painter from California who just happened to volunteer as a relief worker, and one gets the impression he brought his video equipment to Sri Lanka on a whim. It wasn't until Prosser got back to the States that a friend told him he had the bones of a decent feature film. His friend was right. Although the amateur origins of And the Sea Took Usare obvious throughout, they help a lot more than they hurt. Devoid of flourish or flash, the movie allows its subjects room to breathe and speak for themselves. Even Michelle Phillips' gorgeous narration the only overtly professional part of the production is respectfully reserved, taking a back seat to the rough-and-tumble images captured by Prosser's camera. And the camera captured some pretty incredible things. American media outlets did no justice to the grievous wounds inflicted by the tsunamis, but they are seen very plainly in And the Sea Took Us. They're shocking, but Prosser's movie isn't especially sad. Rather, the film is cautiously optimistic, capturing the rising spirits of the people in and around Marwella as they work with friendly strangers to put their lives back together. It's pretty rare to see such unabashed goodness on film hospitals getting reconstructed, the fishing industry being restored, people smiling and laughing and being decent to one another. One could gripe that the images of kind Westerners helping the poor natives smack of noblesse oblige, but that would be cynical. The people of Marwella are anything but. (Sunday, November 12, 3:15 p.m., Cinema Paradiso; 65 minutes.)
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We're happy to announce that we've teamed up with Night Vision Ops, Night Optics USA, and Ben Hansen to bring you exclusive deals on night vision goggles. Hansen, best known for his role on Syfy's Fact or Faked, is the ...Read More »
Are aliens attacking our nuclear arsenal? 'Unexplained Files' explores this Tuesday
Science Channel is set to explore a highly debated topic within the field of UFO research. Are extraterrestrial civilizations trying to shut down our nuclear weapons? This Tuesday, on The Unexplained Files, hear from retired USAF officer Robert Salas, Paul ...Read More »
"See-through" triangle UFO caught on video using night vision
A military combat instructor says he caught a UFO on video that could not be seen by the naked eye. He described the object as a "Slow flying, low, silent, see-through triangle."Read More »
UFO sightings increasing in Queensland say researchers (Photos)
UFO researchers say UFO sightings are increasing in the state of Queensland in Australia. Recent sightings have included photos and video.Read More »
UFO photo captured over Cinnamon Brow in England
A resident of Cinnamon Brow sent a local newspaper an image of a strange object in the skies over his home. He and his wife saw several of the objects at first, but only one was left by the time he got his camera.Read More »
Major George Filer – UFO Investigations
Retired Air Force intelligence officer George Filer will discuss his experiences onboard an aircraft tanker over the UK when he and his crew were asked to check out a UFO on radar. Later, while serving at Ft. Dix, he was ...Read More »
UFOs over North Carolina beaches – Spacing Out! Episode 86
Multiple witnesses have captured photo and video of strange lights in North Carolina. Plus, Jason McClellan rants about the latest UFO story that took the media by storm. That and other space and UFO news on this episode of Spacing Out!
AIR DATE: 8/29/14Read More »
UFO photo taken at Van Lake in Turkey
A man in Turkey believes he may have taken a photo of a UFO near Van Lake, home of the Van Lake Monster.Read More »
'Huge' UFO reported hovering over small Texas town
A Texas witness at Fairfield reported watching a "very bright, white light" UFO at close range, according to testimony in Case 59342 from the Mutual UFO Network (MUFON) witness reporting database.Read More »
Mysterious lights seen during Napa earthquake not UFOs says scientist (Video)
Several people reported seeing flashes of light after the earthquake that shook Napa Valley on Sunday. Similar lights have been seen after other earthquakes all around the world.Read More »
UFOs caught on video over Skyros Island in Greece
At least 20 witnesses watched several UFOs from the beach on Skyros Island in Greece. One witness caught a few of the objects on video before they sped off at "breakneck speed" into the distance.Read More »
Daily UFO Headlines 8/27/14
- Blink-182's Tom DeLonge just proved that aliens really exist - FasterLouder
- Pilot sees 'strange red glowing light' while en route to Alaska - AOL News
- Musselburgh man's UFO hoax film scoops top prize - East Lothian Courier
- UFO With Changing Colours Sighted By Lower Paxton Township Police In Pennsylvania - International Business Times AU
- Unidentified red orbs spotted off our coast - WCTI12
Police witness UFO in Pennsylvania (Video)
After responding to a call regarding unusual lights in the sky, police in Lower Paxton Township, Pennsylvania say they also witnessed a UFO.Read More »
Song about UFO encounter on new album by Basement Jaxx
An album released this week by Basement Jaxx includes a song about aliens inspired by a UFO sighting one of the band members had in London.Read More »
Yvonne Smith – Alien Abductions at the Hotel del Coronado – August 25, 2014
Open Minds UFO Radio: Yvonne Smith is a hypnotherapist and has been one of the leading researchers of alien abduction for decades.Read More »
UFOs seen by multiple witnesses over North Carolina beaches (Photos)
Multiple witnesses reported glowing orbs of light in the night skies over North Carolina beaches this weekend.Read More »
Radio DJ captures UFO on video in Amarillo
Dallas Chambers, a radio DJ for KISS FM 96.9 in Amarillo, Texas, captured a video of a UFO last night. He says several people were pulled over on the side of the road watching the "strange blue light dance around the sky of Amarillo."Read More »
2015 International UFO Congress offering major discount till September 5th
Just 19 more days to take advantage of the super early-bird registration rates for the 2015 International UFO Congress, sponsored by Open Minds! The International UFO Congress is the largest annual conference on UFOs, the search for extraterrestrial life, and ...Read More »
Frank Kimbler – Roswell UFO Debris Discoveries – August 18, 2014
Open Minds UFO Radio: Frank Kimbler teaches Geology and other earth sciences at the high school and college level at the New Mexico Military Institute in Roswell.Read More »
Incredible UFO video captured by Western Canadian news agency
On July 17, 2014, local news reporters covering a wildfire inadvertently got more than they were looking for.Read More »


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LOS ANGELES (AP) - Testimony ended Wednesday in the trial to determine whether Donald Sterling's estranged wife can sell the Los Angeles Clippers in a proposed $2 billion deal with former Microsoft CEO Steve Ballmer.
COLORADO SPRINGS, Colo. (AP) - Leaders from the four U.S. cities in the running to bid for the 2024 Summer Games will meet with U.S. Olympic Committee leadership Friday in the first gathering to include representatives from all the major interested parties.
PLA D'ADET, France (AP) - On the last of four Pyrenees ascents, Rafal Majka winked at a French TV camera and tugged playfully at a motorcycle's antenna.
PASADENA, California (AP) - Manchester United made an impressive debut under coach Louis van Gaal on Wednesday night, with Wayne Rooney scoring twice late in the first half of a 7-0 friendly victory over the LA Galaxy.
SANTA CLARA (AP) - The San Francisco 49ers are eager to move forward from a forgettable offseason.
OAKLAND (AP) - The Athletics have agreed to a 10-year lease extension to stay in Oakland, the team and city officials announced Tuesday.
OAKLAND (AP) - Oakland Athletics right fielder Josh Reddick returned from a second stint on the disabled list because of an injured right knee.
OAKLAND (AP) - The Golden State Warriors and swingman Brandon Rush have completed the deal they agreed to last week.
BAGNERES-DE-LUCHON, France (AP) - The Pyrenees on Tuesday lived up to their reputation for causing ups and downs at the Tour de France: A French rider climbed in the standings, an American went down, and an Australian rebounding from an ordeal of doping suspicions won Stage 16 in a downhill breakaway.
PHILADELPHIA (AP) - Brandon Crawford hit a bases-clearing double to break a 14th-inning stalemate and Tim Lincecum earned his first career save as the San Francisco Giants beat the Philadelphia Phillies 9-6 on Tuesday night.
OAKLAND (AP) - L.J. Hoes homered with one out in the top of the 12th, and the Houston Astros beat the Oakland Athletics 3-2 on Tuesday night for their first win in four tries at the Coliseum this year.
NEW YORK (AP) - Trying to boost one of the weakest lineups in the American League, the New York Yankees acquired third baseman Chase Headley from the San Diego Padres on Tuesday for rookie infielder Yangervis Solarte and minor league pitcher Rafael De Paula.
LOS ANGELES (AP) - The interim CEO of the Los Angeles Clippers testified Tuesday that coach Doc Rivers told him he will quit if Donald Sterling remains the owner of the team.
CLEVELAND (AP) - Andrew Wiggins will sign his rookie contract with the Cavaliers. It's still not clear if he'll play for them.
NEW YORK (AP) - The Seattle Seahawks start the preseason right where they ended last season, as the No. 1 team in the AP Pro32 NFL power rankings.
HUNTERSVILLE, N.C. (AP) - For Tony Stewart, there was no greater joy than escaping his everyday life and climbing behind the wheel of a sprint car. He loves the feel, the way they drive, the purity he finds at all the tiny dirt tracks across the country.
SAN FRANCISCO (AP) - Ian Kennedy pitched seven innings for his third consecutive win, Seth Smith hit a tiebreaking double in the sixth inning and the San Diego Padres beat the San Francisco Giants 4-1 on Friday night.


text: Presented by Daniel Toriola Niche keywords may be fewer in number but they have fewer competing web pages. If you have a web page that is based on niche websites you are going to have a greatly increased opportunity to land on the top rankings of the major search engines. Click here to know more Facing 99.9% Downtime With Your Web Host? That's What Happens When They Cram Too Many Websites On Their Servers. We Don't! We Won't! Ever! Try Us, You'll Never Go Back. 100% No Questions Asked Money Back Guarantee Applies To All Hosting Accounts. Click here to know more Basics of Search Engine Optimisation (SEO) By Lijo George What is SEO? Search Engine Optimization is a step by step process in which a web site is optimized to the expectations of Search Engines. What is the relevance of Search Engines in Internet Marketing? Search Engines are the link between the customer and the product. 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Because effective SEO may require changes to the HTML source code of a site, SEO tactics may be incorporated into web site development and design. The term search engine friendly may be used to describe web site designs, menus, content management systems, URLs, and shopping carts that are easy to optimise. The practice of search engine optimisation is all about making sure that the website evolves and grows. The way of doing this is by modifying both the internal and the external aspects of a site in order to increase the traffic that a site receives from search engines. Search Engine Optimisation (SEO) is a very broad field, with various aspects encompassing a variety of disciplines ranging from Web design and development to public relations. 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Credit: Bryan Haraway/Getty Images
Sponsored by the International Safety Equipment Association (ISEA), the Fall Protection Showcase increased the concrete industry's awareness of proper practices and procedures, and the products available to achieve safe worksites.
The showcase was a hands-on education/demonstration area where attendees learned how to properly use personal fall protection equipment and review the three vital components that make up a complete fall protection system—anchorage, body support, and means of connection.
Experts from 3M, Capital Safety, Elk River, and Honeywell Safety Products were on hand to discuss how to select, inspect, and adjust a body harness; how to select the proper means of connection for an assigned task; and how to combine the two selections into a fall protection system.
Attendees also had the opportunity to practice what they learned. Following their workstation training, the attendee walked through a worksite simulation to practice connections.
The content for this educational activity was drawn from the content found in the International Safety Equipment Association's "Use and Selection Guide for Personal Fall Protection Equipment." This document is available here.
Fall Protection
Jobsite Safety
The federal Occupational Safety and Health Administration is investigating three...
Capital Safety
Rick Yelton
ACI 318-14 will help increase concrete's use in the future
World of Concrete
Once again, Fall Protection tops the list of the Occupational Safety and Health...
In a final ruling on cranes and derricks in construction, the Occupational Safety and...
The Share the Road program sends professional truck drivers with exemplary safety...
There are several important industry trends which might influence your business...
Please read our Content Guidelines before posting.
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2014 Hanley Wood Media, Inc. All rights reserved.


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just On Call - Gruppo Campari CEO silent on Whyte & Mackay bid
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- Nick Lachey
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|Song details
|What's Left Of Me
|Nick Lachey
|What's Left Of Me [2006], Track 1
|Blues, Pop, Rock
|4,483 (−1,070) history »
|- view all »
|Referring urls
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|Song lyrics
Watched my life pass me by
In the rearview mirror
Pictures frozen in time
Are becoming clearer
I don't wanna waste another day
Stuck in the shadow of my mistakes, Yeah
'Cause I want you, and I feel you
Crawling underneath my skin
Like a hunger, like a burning
To find a place I've never been
Now I'm broken, and I'm fading
I'm half the man I thought I would be
But you can have, what's left of me
I've been dying inside
Little by little
Nowhere to go I'm going out of my mind
In endless circles
Running from myself until
You gave me a reason for standing sti-i-i-i-i-i-i-i-ill
And I want you, and I feel you
Crawling underneath my skin
Like a hunger, like a burning
To find the place I've never been
Now I'm broken, and I'm fading
I'm half the man I thought I would be
But you can have, what's left of me
Falling faster barely breathing
Give me something to believe in
Tell me it's not all in my head
Take what's left, of this man
Make me whole, once again
'Cause I want you, and I feel you
Crawling underneath my skin
A hunger, like a burning
To find the place I've never been
Now I'm broken, and I'm fading
I'm half the man I thought I would be
You can have, all that's left
Yeah-Yeah-Yeah, what's left of me
Oh-Ho-Oh, Oh-Ho-Oh-Oh-Whoa
I've been dying inside you see (Inside you see)
I'm going out of my mind (Out of my mind)
Out of my mind (Out of my mind)
I'm just running in circles all the time
Will you take what's left?
Will you take what's left?
Will you take what's left? (Of me)
Just running in circles in my mind
Will you take what's left?
Will you take what's left?
Will you take what's left? (Of me)
Take what's left of me
submitted on February 6th, 2006
corrected by Edward Louk on October 12th, 2014
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|76 Comments
|0 likes - like | 10-07-2012 12:03 toniedoll
66 posts
|i love this song, nick sand his heart out and u can listen to his emotions! yes nick,i will take whats left of u
|0 likes - like | 02-12-2010 17:35 CherryPenguin
120 posts
|I really like this song
|0 likes - like | 30-08-2010 23:53 Risa1600
230 posts
|Great song.
|0 likes - like | 22-07-2007 12:36 Private_Secret
251 posts
|This is Nick Lachey's best song. Kinda sad, but very deep. I like it.
|0 likes - like | 10-02-2007 00:52 Silent_Captain
1 posts
|At first I took this song as a male equivelant of "The First Cut Is The Deepest" by Leona Lewis (correct me if I'm wrong), but then I got to thinking about it. This song is written by a broken man. He placed all of his faith and love in a woman who broke his heart, and maybe as some of you have said, he deserved it. I can relate, but am I the only person who sings this song to God instead of a woman? God is the only one who can heal a heart after a woman has ripped it out and stomped on it. Don't take me for a preacher, I've messed up so bad I have no business standing before God. I disobey him, and get destroyed by the same women time and time again, then come crawling back to God telling him he can have what's left of me. God knows I'm a slow learner and will continue to get my heart kicked around when I stray from his side, but he still takes me back everytime, and I love him. Amen.
|0 likes - like | 22-10-2006 07:38 eee
4 posts
he is a seedy mole im glad they broke up i hate em both ewwwwww!!!
worst song ever!!!!!!!!!!!!!!!!!
|0 likes - like | 01-10-2006 02:19 Marlon1217
43 posts
|this song is really great
strong emotional lyrics
i feel bad for him poor nick...
|0 likes - like | 03-09-2006 17:38 rorgil
6 posts
|viva il-faqizmu kbir ta' Nick Lachey!!!!!!!
|0 likes - like | 20-08-2006 16:52 dark_haze
198 posts
|0 likes - like | 16-08-2006 16:18 RockinDiva
248 posts
|this is so meant for jessica. i think its soo sweet that he made a song about how he was feeling and jessica goes and makes a song about something meaningless like a public affair. i still like both songs tho.
|0 likes - like | 16-08-2006 00:29 grounded_angel
6,593 posts
|OMG, this song is so lame! I can't listen to it anymore, they play it everywhere!
|0 likes - like | 12-08-2006 19:51 sally_87
2 posts
|this is such a great song. It so full whit emotions
|0 likes - like | 12-08-2006 12:27 mary_mari
13 posts
|this is very good like it very much!!!!
|0 likes - like | 10-08-2006 02:18 cloudyair214
62 posts
| Cute song!
Cause I want you, and I feel you... cool.
I love Nick Lachey. He is sooooo cute and nice!
Cool song!
|0 likes - like | 08-08-2006 17:04 Areyoulost
8 posts
|Trygid, you are hilarious, yet disturbing. This song is all right, but I wouldn't go so far as to say that I cried while listening to it. Also, I was reading People magazine, and apparently Nick is with that girl from TRL who's in his video for this song. There were pictures of them making out in a restaurant. Jeez, celebrities these days. They go and complain about the press, but obviously people will take pictures of them if they're practically on top of each other.
|0 likes - like | 07-08-2006 08:27 trygid
6 posts
|I want to play this at my funeral for fun..
Imagine trying to make people think about what will happen to my body under a heap of dirt with worms and stuff while I play this part of the song
Cause I want you -- and I feel you -- crawling underneath my skin
Like a hunger, like a burnin -- to find a place I've never been
Now I'm broken, and I'm faded -- I'm half the man I thought I would be
But you can have -- what's left of me.
Heh... .. I'm twisted.. but maybe someone else thinks it's funny too
|0 likes - like | 06-08-2006 19:12 kevina
183 posts
|i dont agree with u IMAGREATPERSON. this is an imotional video what did u expect?Dance and jumping.this video is awesome
love it loveit.sooooooooooooo emotional
|0 likes - like | 04-08-2006 17:24 Imagreatperson
2 posts
| This song makes me feel good inside but he could use some practice with his vocals.
His video is one of the worst ever
|0 likes - like | 26-07-2006 20:35 forever_yoursx3
8 posts
|this is prob one of my favorite songs. i seriously liked this song so much that before i was able to download it on itunes i would go to this girls myspace to listen to it over and over lolol
but yea i dont think its for jessica either
|0 likes - like | 25-07-2006 15:23 luv2talk
32 posts
|i thought he broke up with her when he made this? probably did, in that case it wasn't meant for jessica!! plus i think if it was for her, he would have her in the video!! dontcha agree? and it DOES sound like he's talking bout a rash, my friends and i have oficially decided!!! lol
Tzila H.
|0 likes - like | 24-07-2006 19:57 crazeebaybiee
1 posts
|Aww this song brings so many memories.
It's the song that i slow danced to with my guy best friend, (who ive had a crush on for a year ) when he asked me to go to a dance with him "as friends" ....
It's a great song, though I don't think that it was meant for Jessica.
|0 likes - like | 24-07-2006 19:09 hurtz2luvu2010
6 posts
|It is for Jessica because he was on MTV and he was talking about it.. But its a great song..!! I love it!
|0 likes - like | 24-07-2006 16:27 luv2talk
32 posts
|oh, sorry bout that the computer was acting up
|0 likes - like | 24-07-2006 16:25 luv2talk
32 posts
|"and I feel you -- crawling underneath my skin
Like a hunger, like a burning"
does anyone else agree that it sounds like he's talking about a rash when he says this line? my sister's friend does!! lol just wondering. other than that it's O.K.!! i also lke the piano at the beginning the song is very dramamtic!! lol
|0 likes - like | 24-07-2006 16:22 luv2talk
32 posts
|"and I feel you -- crawling underneath my skin
Like a hunger, like a burnin "
Does anyone else think it sounds like he's talking about a rash when he says that line? well I do it sounds kinda funny my sisters friend agrees!! lol it just sounds funny whatever the song's O.K. yeah i also like the piano


text:
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New York City fast food workers plan strike
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Salon.com: Fast food workers this morning planned to walk off the job in what organizers promised would be the largest-ever strike.
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Athens News Courier (Newspaper) - December 9, 2005, Athens, Alabama Clownin' around ingling Bros. Circus is performing in Huntsville, an inside look Sunday Blockbuster deal Braves pick up shortstop Renteria from Red Sox IB Neivs-Courier Serving Athens and Limestone Coi nt\ : A Commi nitv of Tradition and Fi ti re Fridvv, De( ember 9, 2005 enewscourier.com 50 Cents ^cy&ci' fwOth/Ch/^ Audrey Moyers Siil')scriber of the day Nutcracker sweet Local students perform in performances of "The Nutcracker" in Huntsville. 6a urn Hey, Sound Off: Concerning the renaming of Browns Ferry Street in honor of Martin Luther King Jr.: Why disrupt and inconvenience the people who have lived there for years to honor a man who has had more acclaim than any man in American history? The majority of people who travel this street either live there, are going to school or work or are hauling chickens or cotton. The same traffic travels this street every day. Most of the people traveling through our state do not have the faintest idea of the location of this street. If it is recognition and exposure you for for Dr. King, this would only be seen by the local people. More Sound Off Valley, 5A Get the news with your morning coffee Subscribe to The Seu's-Courier % 232-2^20 Index Classified 4-6B Comics..........3B Headlines 4A Ledger .........11A Obituaries 2A Lewis Downs Thomas N. Dunnivant Charlotte Dean Patterson Margaret E. Raney Religion 9-11A Sports.........1-2B Valley...........5A Weather.........2A Daily Bible Moment 31 is good for me that I have heeri afflicted, that I may learn your statutes. Psalm 119:71 imestone Chapel iPcM 322 HMV.31.\>AikeiK 256-232-1051 256-771-0934 7 69847 00001 Man charged in rampage Motive unclear in Elkmont man's attack, authorities say B\ SONNV 11 RNFR sonny(aflthensne\\'s-couher.cum Limestone County authorities said Thursday thev' have not detemiined why a 59-year-old Elkmont man became so irate Wednesday that he chased his daughter w ith a 2-by-4, beat the car she w as in w ith the board and threatened her tnend w ith a pocket knife. "We know he was highly intoxicated at the time and we we've been told this tvpc of behavior from him has happened before when he dnnking," said Limestone County Chief Investigator Stanley McNatt. "His daughter and a l-year-c1d baby who were inside the v ehicle w hen he beat out the back windshield were slightly cut by the broken glass. But they did not seek medical treatment." Billy Joe Blankenship of 25777 Highland .\ve., Flkmont, was in the Limestone County Jail Thursday charged with two counts of domestic v iolence. two counts of reckless endangemient. public intoxication and second-degree criminal mischief McNatt said all those charges stem from the Wednesday attack at Blankenship's home. Deput> Jay Stinnett responded to the call for help at Blankenship's home Wednesday and tcxik the suspect into custody after the 10 a.m. attacks. McNatt said It all occurred in the vard at his home. McNatt said the daughter arrived at her father's home to find him highly intoxicated. "She said he became so irate that he started chasing her w ith the 2-by-4. He then pulled a pocket knife on her male friend who was with her at the time. "She said she grabbed the baby, w hich was her friend's grandson, and they got into the 2001 Pontiac Grand .\m. She said her father then started beating the car with the 2-by-4. He knocked out the back vv indshield and put dents in the car by hitting it with the big piece of board." McNatt said Blankenship remained in the Limestone C'ountv Jail Thursday. He said a )udgc had not yet set bond. Bittersweet celebr.\tion 'Home for the holidays' just a state of mind for Katrina evacuees Bv Karen .Middleton Karen(wjathemneviS-couhet:com Salvaged Chnstmas ornaments from the attic of a flood-gutted Bay St. Louis, Miss., house will make the season bright for the Paul and Laura Tlien family in Athens, Ala. Shelly and Michael Underhill can't go back to their W'aveland. Miss., home so they hope that her storm-displaced mother and 96-year-old grandmother can make it here from Florida. And all that James and Indra Chisholm's 15-year-old daughter wants for Christmas is to go back home to Bay St. Louis—but there's no home there. The three families now call Athens home, some temporarily and some hope permanently. They are part of about 30 families living here and 24 families camped at Joe W heeler State Park who evacuated the Gulf Coast ahead of Hurricane Katrina. Uncertain futures characterize their lives in North Alabama but not self-pity. Laura Then (pronounced Thane) gets an update about hurricane evacuee services from United Way Director Kaye McFarland, left. Above are Indra and James Chisholm, and at right, Shelly Underhill. New.s Couricr/Kim Ryiulcrs and Tashia l.ovell "We have our Chnstmas decorations and we cleaned otf the salt water from some CDs, so we will have Christmas music," said Laura Then. "W'e told the kids that Christmas would be like Thanksgiv ing. It will be a time of family togetherness and being thankful. We've been talking a long time about what Christmas is and what it's supposed to be. It's not about the shopping frenz>'. We must seize this opportunity to find the real meaning of Christmas.'' After 17 years in Bay St. Louis, Then (pronounced Thane), a state license examiner, knew the drill well: Hurricane evacuation order, pack a two-day change of clothes, drive to a relative's small farm a few miles inland come back when the coast was clear. See Evacuees, Page 7A NRC fintds minor safety violations at Browns Ferry AP —A Nuclear Regulatory Commission inspection of the Unit 1 reactor at the Tennessee Valley Authority's Browns Ferry Nuclear Power Plant found only low safety violations, officials said. A paperw'ork problem was cited in one case and improper installation of four cable splices in another. The inspection findings were discussed Wednesday at the first public meeting between TVA and the NRC's Unit 1 Oversight Panel. TVA is spending $1.8 billion to restart Unit 1, which it shut down in 1985 amid safety concerns. The restart process is 73 percent complete and startup is slated for May 2007. The NRC inspection found that workers failed to remove some thermal overloads. The plant's licensing manager, Bill Crouch, said those overloads keep motors, which constantly open and close valves, from overheating. Crouch said some valves didn't need to open and close continuously, so a work order asked workers to remove those thermal overloads. "The paperwork was misplaced, and we failed to remove them,'' Crouch said. "The NRC See Violations, Page 3A Deck the rails New's-Courier/KiiTi Rynders Selena Higginbotham hangs a Christmas wreath on the railing outside Beasley Cosmetic and General Dentistry on Hobbs Street. Businesses and homes are decorated across Limestone County in readiness for the Christmas holidays. Alabama 99 bri(jge work postponed By Kelly Kazek kellyCa.aihensnews-courier.com Replacement of Round Island Creek Bridge on Alabama 99 just past the rodeo arena has been delayed again, this time until spring, a city worker said. The bridge will be replaced by State Department of Transportation engineers, who initially planned to have work completed earlier this year. Athens Water Department workers will finish moving mains near the bridge before end of the year, said superintendent Howard Hopkins. "We're relocating a 24-inch main on the east side and an eight-inch main on the west side of bridge,'' he said. "We moved them because they were so close to the bridge.'' Moving those mains, he said, will not affect customers. "It won't affect quality or See Bridge, Page 3A
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Per reports, eight teams put in claim for ex-Eagles defensive end. Terry McCormick
Jason Babin's desire to play for a contending team were dashed Wednesday when the Jacksonville Jaguars claimed him off waivers, per multiple reports.
Babin was let go by the Philadelphia Eagles on Tuesday and according to reports, eight different teams put in a claim on the 32-year-old defensive end who is one season removed from an 18-sack campaign.
Babin has just 5.5 sacks this season, and the well-traveled pass rusher now has the AFC South hat trick, having begun his career in Houston and spending a productive 2010 season with the Tennessee Titans.
It's a good gamble by the Jaguars, who are trying anything they can to jumpstart a 2-9 team. Babin won't get his wish to play for a contender, though, unless the Jags can somehow put the pieces together quickly enough to be competitive in 2013.
Follow me on Twitter @TerryMc13
Terry McCormick covers the Titans for TitanInsider.com
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