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Go to Street Corner Music on Greenfield and 9 ½ Mile, and get YOURS, Two great songs out of 16 that will have you shaking you head as longas you here them!!!!....."People Make The World Go Round"...and "Wes" (Is Still In The House)....
Preserving The Past and Presenting The Future of Jazz Music
Booker Ervin
Booker Telleferro Ervin II (October 31, 1930 – July 31, 1970) was an American tenor saxophone player. His tenor playing was characterised by a strong, tough sound and blues/gospel phrasing. He is best known for his association with bassist Charles Mingus.
Ervin was born in Denison, Texas. He first learned to play trombone at a young age from his father, who played the instrument with Buddy Tate. After leaving school Booker joined the United States Air Force, stationed in Okinawa, during which time he taught himself tenor saxophone. After completing his service in 1953, he studied at Berklee College of Music in Boston. Moving to Tulsa in 1954, he played with the band of Ernie Fields.
Ervin moved to New York to join Horace Parlan's quartet, with whom he recorded Up & Down and Happy Frame of Mind (both for Blue Note Records). Ervin worked with Charles Mingus from 1956 to 1963, appearing on "Goodbye Pork Pie Hat" on the album Mingus Ah Um, "Wednesday Night Prayer Meeting" on Blues and Roots, all of Mingus at Antibes (save for "What Love?") and Mingus Mingus Mingus Mingus Mingus. During the 1960s Ervin also led his own quartet, recording for Prestige Records with ex-Mingus associate pianist Jaki Byard, along with bassist Richard Davis and Alan Dawson on drums. Ervin later recorded for Blue Note Records and played with pianist Randy Weston, with whom he recorded between 1963 and 1966. Weston has said: "Booker Ervin, for me, was on the same level as John Coltrane. He was a completely original saxophonist.... He was a master.... 'African Cookbook', which I composed back in the early '60s, was partly named after Booker because we (musicians) used to call him 'Book,' and we would say, 'Cook, Book.' Sometimes when he was playing we'd shout, 'Cook, Book, cook.' And the melody of 'African Cookbook' was based upon Booker Ervin's sound, a sound like the north of Africa. He would kind of take those notes and make them weave hypnotically. So, actually the African Cookbook was influenced by Booker Ervin."
Ervin died of kidney disease in New York City in 1970, aged 39.
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Anita O'Day
Anita O'Day (October 18, 1919 – November 23, 2006) was an American jazz singer.
Born Anita Belle Colton, O'Day was admired for her sense of rhythm and dynamics, and her early big band appearances shattered the traditional image of the "girl singer". Refusing to pander to any female stereotype, O'Day presented herself as a "hip" jazz musician, wearing a band jacket and skirt as opposed to an evening gown. She changed her surname from Colton to O'Day, pig Latin for "dough," slang for money.
O'Day, along with Mel Tormé, is often grouped with the West Coast cool school of jazz. Like Tormé, O'Day had some training in jazz drums (courtesy of her first husband Don Carter); her longest musical collaboration was with jazz drummer John Poole. While maintaining a central core of hard swing, O'Day's skills in improvisation of rhythm and melody put her squarely among the pioneers of bebop.
She cited Martha Raye as the primary influence on her vocal style, also expressing admiration for Mildred Bailey, Ella Fitzgerald, and Billie Holiday. She always maintained that the accidental excision of her uvula during a childhood tonsillectomy left her incapable of vibrato, and unable to maintain long phrases. That botched operation, she claimed, forced her to develop a more percussive style based on short notes and rhythmic drive. However, when she was in good voice she could stretch long notes with strong crescendos and a telescoping vibrato, e.g. her live version of "Sweet Georgia Brown" at the 1958 Newport Jazz Festival, captured in Bert Stern's film Jazz on a Summer's Day.
Born to James and Gladys M. (née Gill) Colton in Chicago, Anita Belle Colton (who later took the surname "O'Day") took the first chance to leave her unhappy home when, at age 14, she became a contestant in the popular Walk-a-thons as a dancer. She toured with the Walk-a-thons circuits for two years, occasionally being called upon to sing. In 1934, she began touring the Midwest as a marathon dance contestant and singing "The Lady in Red" for tips.
In 1936, she left the endurance contests, determined to become a professional singer. She started out as a chorus girl in such Uptown venues as the Celebrity Club and the Vanity Fair, then found work as a singer and waitress at the Ball of Fire, the Vialago, and the Planet Mars. At the Vialago, O'Day met the drummer Don Carter, who introduced her to music theory; they wed in 1937. Her first big break came in 1938 when Down Beat editor Carl Cons hired her to work at his new club at 222 North State Street, the Off-Beat, which became a popular hangout for musicians. Also performing at the Off-Beat was the Max Miller Quartet, which backed O'Day for the first ten days of her stay there. While performing at the Off Beat, she met Gene Krupa, who promised to call her if Irene Daye, then his vocalist, ever left his band, and in 1939, O'Day was hired as vocalist for Miller's Quartet, which had a stay at the Three Deuces club in Chicago.
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Benny Goodman
Benjamin David "Benny" Goodman (May 30, 1909 – June 13, 1986) was an American jazz and swing musician, clarinetist and bandleader, known as the "King of Swing".
In the mid-1930s, Benny Goodman led one of the most popular musical groups in America. His January 16, 1938 concert at Carnegie Hall in New York City is described by critic Bruce Eder as "the single most important jazz or popular music concert in history: jazz's 'coming out' party to the world of 'respectable' music."
Goodman's bands launched the careers of many major names in jazz. During an era of segregation he also led one of the first well-known integrated jazz groups. Goodman continued to perform to nearly the end of his life, while exploring an interest in classical music.
Goodman was born in Chicago, the ninth of twelve children of poor Jewish immigrants from the Russian Empire who lived in the Maxwell Street neighborhood. His father was David Goodman (1873–1926), a tailor from Warsaw, Poland. His mother Dora Grisinsky (1873–1964) from Kaunas, Lithuania. His parents met in Baltimore, Maryland, and moved to Chicago before Benny was born.
When Benny was 10, his father enrolled him and two of his older brothers in music lessons at the Kehelah Jacob Synagogue. The next year he joined the boys club band at Jane Addams' Hull House, where he received lessons from director James Sylvester. He also received two years of instruction from the classically trained clarinetist Franz Schoepp. His early influences were New Orleans jazz clarinetists working in Chicago, notably Johnny Dodds, Leon Roppolo, and Jimmie Noone. Goodman learned quickly, becoming a strong player at an early age and soon playing professionally in various bands.
Goodman made his professional debut in 1921 at the Central Park Theater on Chicago's West Side and entered Harrison High School in Chicago in 1922. He joined the musicians' union in 1923 and by 14 was in a band that featured the legendary Bix Beiderbecke. He attended Lewis Institute (now Illinois Institute of Technology) in 1924 as a high school sophomore, while also playing the clarinet in a dance hall band. (He was awarded an honorary LL.D. from IIT in 1968.) When Goodman was 16, he joined one of Chicago's top bands, the Ben Pollack Orchestra, with which he made his first recordings in 1926.
He made his first record under his own name for Vocalion two years later. Goodman recorded with the regular Pollack band and smaller groups drawn from the orchestra through 1929. The side sessions produced scores of sides recorded for the various dimestore record labels under an array of group names, including Mills' Musical Clowns, Goody's Good Timers, The Hotsy Totsy Gang, Jimmy Backen's Toe Ticklers, Dixie Daisies, and Kentucky Grasshoppers.
Goodman's father, David, was a working-class immigrant about whom Benny said (interview, Downbeat, February 8, 1956); "...Pop worked in the stockyards, shoveling lard in its unrefined state. He had those boots, and he'd come home at the end of the day exhausted, stinking to high heaven, and when he walked in it made me sick. I couldn't stand it. I couldn't stand the idea of Pop every day standing in that stuff, shoveling it around".
On December 9, 1926, David Goodman was killed in a traffic accident. Benny had recently joined the Pollack band and was urging his father to retire, since he and his brother (Harry) were now doing well as professional musicians. According to James Lincoln Collier, "Pop looked Benny in the eye and said, 'Benny, you take care of yourself, I'll take care of myself.'" Collier continues: "It was an unhappy choice. Not long afterwards, as he was stepping down from a streetcar—according to one story—he was struck by a car. He never regained consciousness and died in the hospital the next day. It was a bitter blow to the family, and it haunted Benny to the end that his father had not lived to see the success he, and some of the others, made of themselves. Benny described his father's death as 'the saddest thing that ever happened in our family.'
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Lalah Hathaway
Eulaulah Donyll Hathaway (born December 16, 1968) best known as Lalah Hathaway, and sometimes referred to as the First Daughter of Soul, is a contemporary R&B and jazz and Grammy Award winning artist. She is the daughter of soul singer Donny Hathaway and a classically trained vocalist. In 1990, Lalah Hathaway released a self-titled album. The album's first single was "Heaven Knows", produced by Derek Bramble. The follow-up single was "Baby Don't Cry" produced by Angela Winbush.
In 1991, Hathaway released her extended play, Night & Day in Japan. A Moment was released in 1994, debuting at #34 on the Top R&B albums chart. The lead single "Let Me Love You" charted on the Hot R&B charts at #37. In 1999, Lalah Hathaway collaborated with Joe Sample and released her third album The Song Lives On. After a five-year hiatus, Hathaway returned with her fourth album Outrun the Sky. The single "Forever, For Always, For Love" peaked #1 on the Hot Adult R&B Airplay.
In 2007, Hathaway signed to Stax Records and in 2008 released her fifth album Self Portrait. It was released on June 3, 2008 in the United States, debuted at #63 on the Billboard's Hot 200 and reached the top ten on the Top R&B albums chart, making this album, Hathaway's most successful album to date. She received a Best Female R&B Vocal Performance Grammy Award nomination for "That Was Then". She went on to win the Grammy Award for Best R&B Performance along with Snarky Puppy for "Something" in 2014.
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Lee Morgan
Lee Morgan was born in Philadelphia on July 10, 1938. He began his trumpet studies with a private instructor, and continued them at Mastbaum High School for the Arts, where he also played the alto horn. A fan of jazz from an early age, he was exposed to a wide variety of live music in the vibrant Philadelphia music scene, which had produced such notables as John Coltrane, Benny Golson, the Heath brothers, and many others.
By the time he was 15, Morgan was leading his own group with bassist James "Spanky" DeBrest as his partner. He was also taking part in Tuesday night workshops at the Music City club which brought him into early contact with his main early influence, Clifford Brown.
After Morgan graduated from Mastbaum in 1956, he and DeBrest subbed with the Jazz Messengers when Art Blakey arrived in Philadelphia short two musicians. "Spanky stayed on," Morgan explained in the liner notes to his first Blue Note album. "I could have stayed too, but I didn't want to sign a contract, so I left after two weeks. Then very soon after that, Dizzy came back from his South American tour. I'd met him a couple of years before at the workshop and he knew about me. He needed a replacement for Joe Gordon, and I needed some big band experience, so it worked out fine."
After the untimely death of Clifford Brown 1956, Morgan was recorded often, viewed as a like successor to Brown's legacy (the Blue Note label recorded Morgan six times as a leader over a span of 15 months, and Morgan appeared extensively as a sideman on others' recordings during this period).
In 1958, Morgan left Gillespie's big band to join Art Blakey's Jazz Messengers, with whom he remained until the summer of 1961 (when he was replaced by Freddie Hubbard). Problems with heroin forced Morgan into a period of low profile in Philadelphia. He returned to New York in 1963, and his first recording, The Sidewinder, became his greatest commercial success (the title tune was such a hit that Chrysler used it behind an automobile ad during the 1965 World Series).
When The Sidewinder became a hit, Morgan was back temporarily with Art Blakey (1964-1965); he left in 1965 to lead his own bands and pursue the commercial success resulting from his record sales.
In the last four years of Morgan's life, he was one of the leaders of the Jazz and People's Movement, which demonstrated during the taping of talk and variety shows during 1970-71.
Morgan's later bands featured Bennie Maupin or Billy Harper on saxophone, and while the modal jazz direction taken by many other bands became more prominent in his compositions, Morgan remained at heart a hard-bop trumpet player.
On February 19, 1972 his common law wife shot and killed him during an argument at Slugs', ending his life at the age of 33. Lee Morgan's recorded legacy is immense; he recorded many records throughout his career as a sideman, and led 25 albums for Blue Note plus sessions for Vee-Jay, Roulette, Jazzland and Trip.
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Al di Meola
Guitarist Al di Meola first rose to prominence as a blazing jazz fusion player before his playing matured and he began to conquer other styles, such as acoustic Latin music. Born on July 22, 1954, in Jersey City, NJ, di Meola briefly studied at the Berklee School of Music in Boston during the early '70s before accepting a job replacing guitarist Bill Connors in fusion trailblazers Return to Forever (a group that included such monster instrumentalists as keyboardist Chick Corea and bassist Stanley Clarke) in 1974. It was with di Meola that Return to Forever enjoyed their greatest commercial success, as such releases as 1974's Where Have I Known Before, 1975's No Mystery, and 1976's Romantic Warrior cracked the U.S. Top 40 before di Meola jumped ship to launch a solo career.
What followed remains some of the finest jazz fusion guitar-based recordings ever: 1976's Land of the Midnight Sun, 1977's Elegant Gypsy (which would eventually earn gold certification in the U.S.), and Casino, plus 1979's Splendido Hotel, before uniting with fellow guitar greats John McLaughlin and Paco de Lucía for 1980's Friday Night in San Francisco. Throughout the '80s and '90s, di Meola racked up numerous accolades (including earning yearly top honors in Guitar Player Magazine polls), kept on issuing solo releases on a regular basis, and played with others, including releases by Stomu Yamash'ta, Paul Simon, Stanley Jordan, and David Matthews, as well as further work with such former bandmates as Corea, Clarke, de Lucía, and McLaughlin. During the '90s, di Meola turned his back almost entirely on fusion to concentrate more on acoustic-based world music, as evidenced by such releases as World Sinfonia, Di Meola Plays Piazzolla, and Heart of the Immigrants, among others. Since that time, Di Meola has continued this eclectic approach with releases like 2003's Revisited, 2006's Consequence of Chaos, and 2007's Diabolic Inventions and Seduction for Solo Guitar, Vol. 1: Music of Astor Piazzolla.
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Help Us Keep Jazz Music Alive!
Gee Caver In Support of Baker's Keyboard Lounge
The tag line for my company, Key of Gee, is "Have A Very Musical Day". My life is filled with rhythms and sounds. I am listening, writing reviews, singing and humming all day. A friend asked if I could go 24 hours without turning on music. I told him I could and then began to wonder "what was I thinking?"
I took the dare and learned a great lesson. I kept to my regular routine – up early tied up my walking shoes – headed out for some exercise with no IPod – no music!
Walking my regular route, I noticed a large pothole in the street. Every vehicle that hit that hole had a different sound da-dum da-dum. The business on the corner flies three flags. As the wind blew the flags there was a whip, pop, whip sound and the rope on the flags was banging the pole, clang um clang. I started smiling, is nature making me cheat?
Car horns blowing, loud mufflers, dogs barking, birds chirping -- the leaves on the tree – the sound of my shoes hitting the pavement -- everything has a sound – its own cadence.
For 24 hours, I didn't turn on any music. I took the time to be present in the moment and enjoy my surrounding and heard some wonderful sounds. And I still had a Very Musical Day.
This year, Baker's Keyboard Lounge celebrated 76 years of Jazz – maintaining its standing as the world's oldest Jazz Club.
In an effort to keep the music playing, Roger Tucker and Three Quarter Step will host a Wednesday Night open mic Jazz Jam at Baker's Keyboard Lounge. Come out and hear Jazz-America's music performed by Detroit's premier artists. In the weeks to come there will be fabulous door prizes and special celebrity guest performances. You won't want to miss a week.
The open mic Jazz Jam starts Wednesday, October 20, 2010, 9:30pm. All Musicians and vocalists are invited to perform.
Baker's is known for hosting the best in Detroit's Jazz including: James Carter, Rayse Biggs, Calvin Brooks, Al McKenzie, Penny Wells, Allan Barnes, Vonne', Jazzeray, Gwen Dommond, David Myles and Mylestones, Guymon Ensley, Ange Smith, Ola Hemphill, Rene King-Jackson, Earl Klugh, Straight Ahead, Port of Call, to name a few. Come and experience standing on the stage that also hosted: Dave Brubeck, Donald Byrd, Oscar Peterson, Sunny Stitt, Kenny Burrell, Jon Lucien and Sea Wind. Mix with the spirits of Nat King Cole, Ella Fitzgerald, Liberace, Dr. Teddy Harris, Ken Cox, Donald Walden and the list goes on and on.
Calling All Past Performers -- It's up to us to keep the music playing!
Baker's Keyboard Lounge
20510 Livernois
Detroit, MI 48221
Check out SV Mix Radio @
Mindy Abair
Born c. 1969, in St. Petersburg, FL; daughter of Lance (a saxophone player and keyboardist) and Linda Abair. Education: Attended University of Northern Florida; graduated from Berklee College of Music, magna cum laude, 1991.
At a time of sagging sales for contemporary and smooth jazz, pop-inspired saxophonist Mindi Abair has brought the cool factor back onto the jazz scene, boosting not only her own popularity, but that of an entire genre as well. With her heavy emphasis on the sounds of R&B and dance music as well as pop and rock, her jazz tunes defy categorization, and have attracted many new, young listeners to the genre. Although most clearly defined as a jazz musician, she cut her teeth playing the saxophone for pop superstars the Backstreet Boys. That connection showed clearly in her 2003 major label debut, It Just Happens that Way. "Lucy's," a single from the album, debuted at the number one position on the Radio & Records chart for most airplay. Following on the single's heels, the album itself landed in the top ten on the Billboard contemporary jazz chart.
Abair grew up in St. Petersburg, Florida, in a family of musicians. Her father, Lance, was a saxophone player and keyboardist. His band, the Entertainers, frequently played on the road, and Lance took his family along with him, including Abair and her mother, Linda. Abair was the third generation of musicians in the family; her grandmother had been an opera singer. Young Mindi Abair learned to play the piano when she was five years old, while on the road with her father. She soon fell in love with the saxophone, again following her father's example. She had learned to play the sax by the time she was eight years old, and that same year she began writing her own music.
By the time she reached high school, Abair was an accomplished musician, playing in her high school marching band, in which she also played drums. There was never a point at which she decided to make music her life, she recalled later, she simply always was a musician. Her early influences were not only the music of jazz musicians such as Bill Evans, Miles Davis, and others, but top 40 hits as well, and this blend of tastes defined her work in later years.
After graduation from high school, Abair won a full scholarship to the University of Northern Florida to study music. But she soon found that the music department was not receptive to her interest in contemporary jazz. "It was a great experience," she later explained to Kevin Walker in the Tampa Tribune, "but they were very traditional." After a year she transferred to the renowned Berklee College of Music in Boston. There she found herself at home with instructors and fellow students, who appreciated her desire to fuse jazz with rock, dance, and pop sounds. Among her most influential teachers was famous saxophone instructor Joe Viola, who helped her further hone her composition skills. After class she got even more experience playing in jam sessions with classmates in the dorms.
Following her graduation from Berklee, Abair moved to Los Angeles. Unlike many of her peers, she chose not to get a day job to help support herself; she expected her music to support her immediately. To this end, she put together a band to play in clubs at night and, lacking other work, she played on the streets of Santa Monica during the day. The gamble paid off when new age recording artist John Tesh spotted her in one of her club gigs and invited her to join a concert tour he was putting together. She accepted, and her career was off and running. More job offers rolled in, and soon she was playing with such acts as the Gap Band, Adam Sandler, Mandy Moore, Teena Marie, and perhaps most significantly, from 1999 to 2001, the pop group the Backstreet Boys.
Bud Harner, a Verve record label representative, caught one of Abair's acts in concert. He later described the scene to Dave Scheiber in the Chicago Sun-Times: "The whole place was just mesmerized by her, this beautiful, young, blond woman ... just burning on the horn." Abair was already committed to a long-term tour with the Backstreet Boys tour, so she and Harner agreed to talk when she returned.
For Abair, the gig with the Backstreet Boys--two years on the road as the band's featured sax player--marked a major milestone in her career. She played in 50,000-seat venues throughout the United States and Europe, making professional contacts and gaining valuable experience that would serve her well in her later career as a soloist. After her return from the tour in 2001, she sent Harner a demo CD, and Verve gave her a contract. The result was an album called It Just Happens that Way, Abair's major label debut. The title of the album came from a 1962 live album by jazz saxophone great Cannonball Adderley, on which he can be heard saying, as quoted on the Verve Music Group website, "Hipness is not a state of mind. It's a fact of life. You don't decide you're hip. It just happens that way."
The album debuted to brisk sales and to critical acclaim. A single from the album titled "Lucy's" hit the number one spot on the Radio & Records chart for most airplay, and the album itself climbed to the top ten on the Billboard contemporary jazz chart. The record label began receiving fan letters from teens, an accomplishment normally reserved for pop stars. Abair has said of her debut that it was the culmination of a lifetime of work, that all of her playing and practicing and performing had been leading up to this achievement. She couldn't have been happier, too, with the success of the album at music stores and among critics, who praised it for its fresh approach to jazz. Abair was proud, not only of landing her own recording contract and playing her own compositions, but for having achieved success in a field largely dominated by men.
Abair has continued to live in Los Angeles. As for the future, she has said she plans to produce many more albums, and to one day start a family. "I grew up on the road," she explained on the Verve website, "so I think I can pull it off.... But I have to meet someone first."
by Michael Belfiore
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John McLaughlin
(born 4 January 1942, Doncaster, South Yorkshire, England), also known as Mahavishnu John McLaughlin, is an English guitarist, bandleader and composer. His music includes many genres of jazz, and rock, which he coupled with an interest in Indian classical music to become one of the pioneering figures in fusion.
In 2010 guitarist Jeff Beck called him "the best guitarist alive".[1] The Indian tabla maestro Zakir Hussain has called him "one of the greatest and one of the important musicians of our times". In 2003 McLaughlin was ranked 49th in Rolling Stone magazine list of the "100 Greatest Guitarists of All Time".[2]
After contributing to several key British groups of the early sixties and making his first solo record Extrapolation (with Tony Oxley and John Surman) he moved to the USA where he played with Tony Williams's group Lifetime and then with Miles Davis on his landmark electric jazz-fusion albums In A Silent Way, Bitches Brew, A Tribute to Jack Johnson and On The Corner. His 1970s electric band, the Mahavishnu Orchestra, performed a technically virtuosic and complex style of music that fused electric jazz and rock with Indian influences.
From a family of musicians (his mother being a concert violinist), McLaughlin studied violin and piano as a child and took up the guitar at the age of 11, exploring styles from flamenco to the jazz of Django Reinhardt and Stephane Grappelli. He moved to London from Yorkshire in the early 1960s, playing with Alexis Korner[3] and the Marzipan Twisters before moving on to Georgie Fame and the Blue Flames, the Graham Bond Organisation (in 1963)[4] and Brian Auger. During the 1960s he often had to support himself with session work which he often found unsatisfying[5] but which enhanced his playing and sight-reading.
McLaughlin moved to the U.S. in 1969 to join Tony Williams' group Lifetime. A recording from the Record Plant, NYC, dated 25 March 1969, exists of McLaughlin jamming with Jimi Hendrix. McLaughlin recollects "we played one night, just a jam session. And we played from 2 until 8, in the morning. I thought it was a wonderful experience! I was playing an acoustic guitar with a pick-up. Um, flat-top guitar, and Jimi was playing an electric. Yeah, what a lovely time! Had he lived today, you'd find that he would be employing everything he could get his hands on, and I mean acoustic guitar, synthesizers, orchestras, voices, anything he could get his hands on he'd use!"
He played on Miles Davis' albums In A Silent Way, Bitches Brew (which has a track named after him), On The Corner, Big Fun (where he is featured soloist on "Go Ahead John") and A Tribute to Jack Johnson. In the liner notes to Jack Johnson, Davis called McLaughlin's playing "far in." McLaughlin returned to the Davis band for one night of a week-long club date, recorded and released as part of the album Live-Evil and of the Cellar Door boxed set. His reputation as a "first-call" session player grew, resulting in recordings as a sideman with Miroslav Vitous, Larry Coryell, Joe Farrell, Wayne Shorter, Carla Bley, the Rolling Stones, and others.
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New music from JIBARO MUSIC/PHATSAK RECORDS. The new single is available now at iTunes and all digital outlets. Check it out and download your copy now!
Full CD Dangerous Crosswinds coming soon!
Miles Davis
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I visited yokohama bar bar bar jazz club for celebrate Mr takakuwa<jazz fes,producer's 80years old birthday party>and played with great jazz musicians, I joined with them when I was 19years…Continue
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Like many, I enjoyed watching Tony Brown's Journal on PBS and when it went off the air was disappointed, but here's the Good News, Tony Brown's Journal is back and available for viewing online. Click the banner shown to Subscribe to be sure that you keep up with the Latest News, Informative Discourse with Guests and the Current Events that really matter shared in an objective no-holes barred fashion by one of…Continue
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That's a question that most answer by saying... Well, I have a job, but in reality, the job has them. To be Financially Literate is to have money working for you without trading your time and labor for it. Not long ago, I came across an opportunity which challenged me to come to terms with this question, and Thankfully, my Financial Resources are Improving as a result. The opportunity of which I speak is the…Continue
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Banks release his highly anticipated EP 'Confessions Of An O.G. featuring Kevin Gates and production from Zaytoven and others.…Continue
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[MIXTAPE] Rashad Banks Confessions Of An O.G.
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text:
Guided Busway Wheel Mechanism by Martin Bond
# of 95511
vehicle greeting cards, bus greeting cards, mechanism greeting cards, guide wheel greeting cards, wheel greeting cards, tyre greeting cards, europe greeting cards, cambridgeshire guided busway greeting cards
Guided busway wheel mechanism. Bus entering a guided section of its route. One of the horizontal guide wheels (centre right) is just starting to make contact with the metal kerbs. This gradual contact allows buses to enter and leave the guided sections without excessive slowing. This kerb-guidance system controls the steering of the bus while it is in the guided sections. This bus is operating on the Cambridgeshire Guided Busway (CGB), built from 2007 and opened in August 2011. Photographed near Histon, UK, in September 2011.
Science Photo Library was founded in 1981 by Michael Marten, one of the authors of "Worlds Within Worlds", a book exploring different ways to observe the universe - from electron micrographs, to images of earthrise taken from the Apollo spacecraft. When Marten started receiving requests for the beautiful images in the book, he had an idea of setting up Science Photo Library. Since then, Science Photo Library has continued to work alongside world acclaimed photographers and the leading science and medical experts to provide a central source of the best science and specialist imagery available. Although the collection started with scientific images, it has grown to encompass all aspects of science and their impact on everyday life.
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Find an Internship or Volunteer in Poway, California ( CA )
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Financial Analyst Intern
…This is a part-time paid internship working approximately 20 hours per week. The intern may play a role in preparing analyses and...
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Teledyne Impulse, a leader in the design and manufacturing of high reliability electrical and optical interconnection systems, motorized...
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- 3 Things To Do Today
- » Manage labor pain naturally
- » Prepare for baby's first feedings
- » Teach your little one about animals
Browse Word Of Mom
What Happens When Your Water BreaksPregnancy |
And now for something completely different. I've been thinking about pregnancy and giving birth a lot lately. This does make sense, since I'm pregnant again, and will have to give birth. I know a lot of moms are worried about their water breaking. What happens if it happens in public? Will I know if my water breaks? How do you know if your...Hypnobirthing Method – Labor Pain Relief with Self-HypnosisPregnancy |
The hypnobirthing method is currently one of my favorite childbirth relaxation techniques that I have been researching. I plan on giving birth without drugs or other unnecessary medical interventions, so, as a natural pain management technique, the hypnobirthing method is right up my alley. While reading my many pregnancy and birth books like...C-Section Belly - Where did this come from?!Pregnancy |
I really didn't expect my c-section belly to be any different from a normal belly after pregnancy. I expected to still look a little pregnant after delivery, only because that's what I'd heard. Everyone always tells you not to expect a flat belly right after you deliver. That you'll still look about 5 or 6 months pregnant. But they also...What Are My Chances Of Multiple Miscarriages?Pregnancy |
Having already had one miscarriage, I think it is a natural tendency to wonder if my chance of multiple miscarriages goes up. This is a constant worry of mine and is one of the reasons I have vowed to never tell anyone (other than WTE of course) that I was pregnant until after I was twelve weeks. Yes I'm still flipping through my What To...Diet Soda during Pregnancy – I Totally Need to Cut BackPregnancy |
With my last three pregnancies, I have enjoyed diet soda during pregnancy.'Diet soda during pregnancy (particularly Coke Zero) has been a staple of my life ever since I switched from regular coke around three years ago. Getting pregnant is not an easy endeavor for me, so I'm doing my darnedest to stay pregnant for the duration.'I know that...Reglan to Increase Breast Milk – Should You, or Shouldn't You?Pregnancy |
In an ideal world I'd do everything natural and organic for my baby boy. That's one reason I chose to breastfeed instead of exclusively formula feeding. There are many benefits to breastfeeding, and I'm committed to giving my baby, Noah, the best nutrition possible. However, breastfeeding is turning out to be a bit more...SHARP PAINS IN LOWER ABDOMEN...HELP!!!!!Pregnancy |
Hi, im 40 weeks pregnant and for the last 3 days i have been having very painful very sharp pains in the lower right side of my abdomen....its nothing i can really time because the pain is continuous it doesnt stop for hours, it may die down a little bit but never completely disappears. i called my midwife and she just said to take a warm bath...Return of Nausea During PregnancyPregnancy |
I have been feeling pretty good the last 6 weeks or so but the last week has been hard again for me. The nausea in pregnancy has returned! At first I thought I must just have a flu bug or something but that doesn't seem to be the case. Every day this week, I seem to hit a point in the day that the nausea is in full force. I have to...Food During Pregnancy-Turkey Bacon and Peanut Butter?Pregnancy |
The other day I made a pan full of turkey bacon. It's one of my favorite things to do: slide a pan of bacon into the oven, fill the house with that wonderful aroma, and then feast. Usually when I do this I only have a few slices, but on this particular day I had, well, we'll just say more than a few slices. I couldn't get enough of it, and...Pitocin Induction - Friend of FoePregnancy |
Long before my Pitocin induction was scheduled, I'd read all about the potential "evils" of a Pitocin induction. Potenital harmful side effects, ill effects on the baby, unnecessary cesareans, etc. But being the firm believer in modern medicine that I am, and having nothing but the utmost faith and confidence in my doctor, I didn't really think ...MISCARRIED LAST NIGHT - AT 9 WEEKS, 2 DAYSPregnancy |
I hate to bring bad news but I miscarried last night. Didnt see it coming considering my 1st dr appt last Thhursday seemed to go well. Dr did a pap and pelvic on me and actually thought I was further along (more like 10 weeks) and we scheduled a sono for next Friday. Couldnt hear a heartbeat but said it was normal. She saw some bleeding in my...Week 32 Prenatal Visit Brings TerrorPregnancy |
I'm exactly 32 weeks today, and just got back from my most recent prenatal visit. Like most appointments, my doctor did the urine dipstick. He found sugar in my urine once again. Only the fact that I'm constantly testing my glucose levels and he's seen my numbers has reassured him that I do not have gestational diabetes. My weight...Dreaming of Being Pregnant with TwinsPregnancy |
I am dreaming of being pregnant with twins. In addition to many other factors that decrease my chance of having twins, no one in my family has had twins so having twins is pretty unlikely to happen to me. Even if I were to get pregnant with twins, my pregnancy would likely be tough, having twins would be twice the work compared with having one...Rash During Pregnancy- PUPPPPregnancy |
Pregnancy is both a wonderful and amazing thing. However, it does have its negatives and it seems as though I found as many as I could, including a rash during pregnancy known as PUPPP (Pruritic Urticarial Papules and Plaques of Pregnancy). While this complication during pregnancy is definitely a pain, luckily, it causes no harm to the mother...Traveling During the Third TrimesterPregnancy |
I'm back! Did you all miss me? We just got home from our last family vacation before Miss Mo arrives and I have to say, traveling during the third trimester, even this early on, is hard! We had a great time on our trip, but a lot of third trimester pregnancy symptoms made the trip very interesting. Our vacation started with a 10 hour drive up ...


text:
Men's Guide Gear® 2,400 gram Thinsulate Ultra Insulation Rubber Boots, Realtree® Hardwoods Grey®
Item # F341W-160332
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Guide Gear® 2,400 gram ThinsulateTM Ultra Insulation Rubber Boots
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About this title: BradyGames? " Diablo III Signature Series Strategy Guide " includes the following: Complete Quest Guide, covering all four Acts in the adventure. Exhaustive Bestiary, detailing every monster in the game. In-depth coverage of Heroes to maximize player effectiveness in all five Character Classes. Guide to meeting and leveling up the Blacksmith, Jeweler, and Mystic professions, and how to maximize the relationships and crafting from each Artisan. Presentation of item types, weapons, collectibles, and other loot. Plus: discussion of sets of items, how to get better loot, and manage raw materials. The only official resource to Blizzard's Online Auction House. Bid on and win rare items safely and effectively. Screen shots capture numerous indoor and outdoor areas in new regions of Sanctuary.
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Boxy cut
By Karen
from Toronto
Boxy cut of snap top. Crinkle fabric is thinner and thus more see through than other white tops offered in this line. Undergarment shows through. So going back in the box and to the company. Had high hopes.
Bottom Line No, I would not recommend this to a friend
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A Great Buy!
By DD
from Ottawa
Really like this blouse! I have worn it a lot; it can be casual or dressed up.The white is clean and bright, and I love the collar and 3/4 sleeves.Overall I am very pleased with this purchase. Would buy it in black which is not available here but is on the US shopping show. More choices, please TSC!
Bottom Line Yes, I would recommend this to a friend


text: Published: July 13, 2014 3:00 a.m. Artist, art blend together Rachel Von | The Journal Gazette Madeline McCaig works on her art piece during the Chalk Walk on East Main Street in front of the Fort Wayne Museum of Art on Saturday. The Chalk Walk is a community event in which artists may choose to reproduce existing artworks or create their own in a designated square using pastels. Related Participants get kick out of parade


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How Novels WorkOxford University Press 2006; US$ 10.99
Never has contemporary fiction been more widely discussed and passionately analysed; recent years have seen a huge growth in the number of reading groups and in the interest of a non-academic readership in the discussion of how novels work. Drawing on his weekly Guardian column, 'Elements of Fiction', John Mullan examines novels mostly of the... more...
To Seek Out New WorldsPalgrave Macmillan 2003; US$ 41.00
This volume explores the science fiction/world politics intertext. Through detailed analyses of such texts as Blade Runner, Stalker, Star Trek, and Buffy the Vampire Slayer, the chapters in this volume examine the complex and sometimes contradictory relations between world politics, both as discipline and as practice, and discourses of science fiction.... more...
How to Read a BookTouchstone 2011; US$ 16.99
With half a million copies in print, How to Read a Book is the best and most successful guide to reading comprehension for the general reader, completely rewritten and updated with new material. Originally published in 1940, this book is a rare phenomenon, a living classic that introduces and elucidates the various levels of reading and how to... more...
The Theory of CriticsmTaylor and Francis 2014; US$ 57.95
This book is divided into five parts and covers: representation; subjectivity; form, structure and system; history and society; morality, class and ideology. Each part contains several thematic sections in which extracts from different writers and periods are juxtaposed. The study of literary theory has tended to concentrate on very recent developments.... more...
Critical Theory TodayTaylor and Francis 2014; US$ 43.95
This thoroughly updated third edition of Critical Theory Today offers an accessible introduction to contemporary critical theory, providing in-depth coverage of the most common approaches to literary analysis today, including: feminism; psychoanalysis; Marxism; reader-response theory; New Criticism; structuralism and semiotics; deconstruction; new... more...
An Early SelfStanford University Press 2014; US$ 65.00
What role has Jewish intellectual culture played in the development of modern Romance literature? Susanne Zepp seeks to answer this question through an examination of five influential early modern texts written between 1499 and 1627: Fernando de Rojas's La Celestina , Leone Ebreo's Dialoghi d'amore , the anonymous tale Lazarillo de Tormes (the... more...
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Going GlobalTaylor and Francis 2014; US$ 42.95
First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company. more...
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Worlding America explores the circulation of short narratives in the early Americas through a combination of neglected primary materials and scholarly commentary. Building on recent reconsiderations of American literature in light of transnational and hemispheric approaches, it follows the migration of stories from various backgrounds and demonstrates... more...
The Real History of Tom JonesPalgrave Macmillan 2005; US$ 36.00
The Real History of Tom Jones revivifies historical materials from which Henry Fielding constructed the greatest comic novel of the eighteenth century. This study recovers and explores the contexts necessary to understand Fielding's subtle art, such as the bloody conflict for the throne between Stuarts and Hanoverians, a contradictory class system,... more...


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DSWA/C/14/2014 October 8, 2014
"Urshlem" Diocean Center- Beasley, Texas
Blessings to our Cor-Episcopoi, Priests, Deacons, Parish Managing Committee Members, Diocesan Assembly Members and all the faithful of our Diocese!
Dearly Beloved,
By the grace of God, the new Diocesan Center, Urshlem, has been modified and renovated enabling us to conduct many diocesan level events at the center over the past year. However, there is still more work to be done so as to make Urshlem a spiritual center that fully caters to the needs of our growing diocese.
It was decided at the last Diocesan Assembly held May of 2014 in Houston, to build a chapel in the traditional Orthodox architectural style along with a museum with an approved budget of $1.5 million for this first phase of our long-term projects. The primary aim for this chapel and museum is to build a spiritual center where all who visit can experience the beauty and serenity of God's presence. It is intended to be a quiet place set apart for prayer, meditation, and worship that allows for one to be away from the busy and stressful life we often live. A core fundraising committee was formed and has met on different occasions to develop ways to raise funds for this project. It was proposed that in all our major cities, that a stage program be conducted inviting artists from Kerala, as a major fundraising program that can help raise a considerable portion of funds for the construction of the first phase of the developments desired for the Diocesan Center.
As you all know, our faithful are part of other Kerala/Malayalee communities and we cooperate with them for many social and religious programs, and we know that members of these groups will cooperate with us in the development of the Malankara Orthodox Church in the North American Continent. We hope that they would consider this as an opportunity to become part of a great cause. We further hope that it will instill a positive message among the Indian community that the Malankara Orthodox Church continues to rise and grow with a focus on the coming generations in this part of the world.
Therefore, we request you to organize a committee under a convener in each area with individuals from our parishes who can willingly work for the success of this program. The core committee of the Diocese led by the General Convener, Rev. Fr. Slomo Isaac George, and Secretary, Mr. George Geevarghese, will give you more detailed information with regard to this matter. In order to organize such a program effectively, we seek the cooperation of all our clergy and faithful in each area of our diocese. It is our request to all our parishes that priority be given to this fundraiser, and you do not arrange similar programs of fundraising on a parish level till we conclude this diocesan level event in September 2015.
May the intercession of Mary the mother of God, St. Thomas the apostle to India and our saints Mar Gregorios and Dynisios be a fortress for us all.
Yours in Christ,
Alexios Mar Eusebius


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Somebody expressing large amounts of wickness, usually named wayne.
Yo, wick wayne just pooped in that bucket.
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Friday 21 December 2012, 14:37
My sense of humour, a bit like Miranda's, is based around bodily functions and the timeless hilarity therein. Basically I'm a child trapped in a man's body.
When working on Miranda, we're always bringing ideas into the rehearsal room and we either get a gold star from her, or polite but dismissive no - but it's always done in good humour.
Gary and Miranda on the brink of a kiss To test a joke out if we can't decide if something's funny or not, we record it both ways in front of the studio audience and see which gets the best reaction.
Our audience at the recordings are very vocal - be that laughing, sympathising or booing – they make it very clear who they're rooting for.
We had a brilliant time filming this series.
When Gary Barlow turned up I felt like a 12-year-old girl and didn't know what to say to him.
We always have a very high calibre of guest on the show, often because they're fans themselves.
The cast celebrate Christmas together
One of the stand-out moments for me was in episode four when we tried some alternative endings for Dr Gail's departure.
The episode was played out more like a play than a TV show and some of the other cast members weren't warned.
It caused them a bit of a shock when we started to explore the boundaries of Gary and Dr Gail's relationship.
I love working in BBC Television Centre, it's always such fun and there's such a sense of history there, especially in comedy.
When filming this series we overlapped with Strictly and I would frequently bump into contestants like Michael Vaughan and Sid Owen and the various judges around the studios. We often asked them for dancing advice when we had dancing scenes.
We had the honour of being the last studio sit-com to be filmed at Television Centre while it still belongs to the BBC.
I always try to find the truth of the world my character inhabits - be it comedy like Miranda, or serious drama, like The Secret Of Crickley Hall. I approach each challenge the same, basically.
Working on Miranda has its own challenges. Trying to keep a straight face when all around me are losing theirs - that's one the hardest things.
This was interspersed with every time the director said cut, Miranda and I going to a quiet corner of the location where I helped relieve her of her trapped wind.
I hope she doesn't hate me for that.
Tom Ellis plays Gary in Miranda. Tom's byline photo is kind courtesy of Scott McAulay.
Series three of Miranda begins on Wednesday, 26 December at 9pm on BBC One. For further programme times, please see the episode guide.
More on Miranda
Digital Spy: 'Miranda' star Tom Ellis: 'New series is the strongest yet'
Miranda Hart on the BBC TV blog: Miranda: The making of a sitcom
TV Tropes [screenwriting conventions]: Miranda
Comments made by writers on the BBC TV blog are their own opinions and not necessarily those of the BBC.
All posts are reactively-moderated and must obey the house rules.
Join the discussion...
Just watched the Christmas special on i-player with headphones whilst the family watched a serious film on TV. I laughed out loud and then giggled and guffawed and annoyed everyone. I just couldn't stop myself. Miranda is so well written and performed and just brilliant. Very excited about the new series!
I just love this show !! Christmas episode was great
I Absolutely Loved the xmas episode, I was in hysterics. Miranda is the funniest person ever, the script is so well written! I can't wait for the rest of the seris! :)
I absolutely love this show!!! It's brilliant! I am very much looking forward to the next series!! I hope you won't cancel it any time soon.
It is absolutely brilliant! You all are brilliant for creating such an amazing tv show!!
Never seen this before but, have just watched the Christmas episode and i haven't laughed so much at a comedy programme in years. Think i will be watching more of this in future, it is absolutely hillarious.
I love this programme. I don't think I've laughed that much in my entire life! I watch it every single week over and over again and i still haven't got bored!! A truly talented cast!!! cant wait for the next episode! until then i will be watching last episode and yet again crying my eyes out :)
There is not a person i know who doesn't find this show absolutely hilarious! Even if i watch the same episode 100 times I will still laugh the same every time. It NEVER gets old. I only started watching this show on series 2. I wish I could watch the series 1 episodes.
I cannot get over just how brilliant this show is..........................they say
that laughter is the best medicine....................this is better than
medicine..............................and I love the unadulterated madness,
combined with Miranda's slapstick........thank-you - all of you!
Miranda like I call SUCH FUN!! I love it, keep up the good work u guys.
I belong to a drama group, I really love drama also, I was just wondering if maybe you can come to our drama group 1 time to give us some hints maybe or just be out patron? It's a group for people with learning difficulties.
I can't wait for Mondays when Miranda is on, thanks for producing such a funny tv proggramme, it's really excellent!
Such Fun!!!!!!!!!!!!!!! :0)
P.S Tom Ellis is HOT!, go for him Miranda, I would :0)
Every episode is very funny, a great sitcom. Looking forward to many more series being made!
The dinner party episode is the funniest thing I have seen on TV since Morcambe and Wise with Andre Previn. I started watching it on the train and had to stop because I was laughing so much I was scaring the other patients. We love Miranda
Love the programme - but am desperate to know where Mirandas' bedding is from in episode 4?
just watched episode 5. Three Little Words - sooo funny!! Brilliant Brilliant Brilliant!! I have Series 1 and 2 on box set now... think I am going to watch them all again from start from finish!!
more,more, more please this is the cleverest & funniest programme I have had the privilege to watch, keep it up. There is not one Character in it that is not funny & Miranda is wonderful.
Thank you Thank you, everybody at "Miranda". My daughter received the series 1 and 2 dvd for Christmas, and I just got through ep 1 of series 1 and was roling on the floor. I have since watched the whole of series 3 so far, and each episode getting better and better. Top drawer comedy, written and performed so well. A complete breath of fresh air. My favourite comedy programme Thank you again x x x
sorry but miranda hart is a terriable duff actress and not in the least bit funny, more charlie chaplin in a big crimpoline frock...and he wasnt funny either
Thursday 20 December 2012, 18:03
Friday 4 January 2013, 10:31


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Posts Tagged 'droplet digital pcr'
The Power of Partitioning:: Posted by American Biotechnologist on 12-30-2013
Bio-Rad Launches PrimePCR™ Assays for Droplet Digital™ PCR:: Posted by American Biotechnologist on 12-11-2013
Bio-Rad Laboratories, Inc. announced the release of its PrimePCR assays for Droplet Digital PCR systems. This release expands Bio-Rad's current offering by an additional 46 mutation detection assays and 323 copy number assays. In addition, the existing set of gene expression qPCR primer-only assays can now be used with the recently launched QX200™ Droplet Digital PCR system, featuring EvaGreen detection capabilities.
The new ddPCR assays are the only predesigned and fully wet-lab validated assays for digital PCR, alleviating the burden placed on researchers of design and experimental optimization and offering precision and sensitivity without a standard curve. The assays enable novel research strategies and accelerate discovery for inherited disorders, cancer, and infectious diseases.
Many methods for mutation analysis offer poor selectivity and fail to detect mutation events with abundances of less than one in 100 wild-type sequences. Bio-Rad's ddPCR technology provides an absolute measure of target DNA molecules, and together with the PrimePCR mutation detection assays, can enable the detection of one mutant molecule in the background of 100,000 wild-type sequences (0.001%). Measuring these extremely low levels of mutation abundance can lead to dramatically more sensitive and less invasive diagnostics.
Current methods, including qPCR and next-generation sequencing, also lack the resolution needed to accurately analyze copy number variation (CNV). Due to their high precision and absolute measurement capability, ddPCR assays enable the quantitative discrimination required to resolve small-fold changes in gene copy numbers. ddPCR assays can also be used to detect subsequent changes in the expression of target genes.
PrimePCR ddPCR assays are available in multiple reaction sizes and are compatible with both the QX100 and QX200 platforms using the ddPCR supermix for probes.
For more information on Bio-Rad's PrimePCR products, please visit www.bio-rad.com/PrimePCR.
Using Droplet Digital™ PCR to Quantify Levels of HIV Reservoirs:: Posted by American Biotechnologist on 12-04-2013
Emerging Applications of Bio-Rad's Droplet Digital™ PCR Technology:: Posted by American Biotechnologist on 11-06-2013
Since its introduction in 2011, Bio-Rad Laboratory's Droplet Digital PCR (ddPCR™) technology has demonstrated the potential to be a transformative technology, particularly in clinical applications.
In the past, tools developed for such applications have been limited by their inadequate precision and/or their lack of sensitivity for detecting rare species. But thanks to ddPCR technology, researchers can now focus on more of these "needle-in-a-haystack" problems. Less than two years since Bio-Rad brought ddPCR systems to the market, their application has resulted in nearly 50 peer-reviewed publications citing the technology.
The advantages of ddPCR technology have already had an important impact on medical research.
"The HIV community, for instance, has benefited from ddPCR's ability to make more sensitive measurements, which can also depend on its attribute of increased precision," said George Karlin-Neumann, the scientific affairs director at Bio-Rad's Digital Biology Center. "To have greater sensitivity down to very, very low levels depends on being able to distinguish something from nothing. You need a system that inherently has very low noise."
Droplet Digital PCR Is a Sensitive Tool for Detecting Residual HIV DNA
A great example of the clinical potential of ddPCR systems is the work of Matt Strain and Douglas Richman of the Center for AIDS Research at the University of California, San Diego School of Medicine, who validated the technology's performance in HIV provirus detection. Subsequently, in collaboration with Deborah Persaud of Johns Hopkins Children's Medical Center in Baltimore, the researchers used the technology to demonstrate that an infant born with HIV was functionally cured.
In a recent BioTechniques podcast, Dr. Strain said that ddPCR assays demonstrate an increase in precision and accuracy over their entire dynamic range relative to real-time PCR assays, particularly at low numbers. Additionally, the total cost per sample of Droplet Digital PCR assays is at least 10 to 100 times less than that of older chip-based digital PCR systems.
"When you're talking about factors of a hundred or more in cost, there really isn't any comparison," said Dr. Strain.
Dr. Richman will present information on using ddPCR to detect latent HIV, including assaying rare events in a large number of cells and retrieving clinically relevant data.
A Glimpse at Droplet Digital PCR's Future in Diagnostics
The research group headed by Hanlee Ji, an assistant professor at Stanford University School of Medicine, focuses on translational and clinical questions of cancer genetics that, once answered, have the potential to improve cancer patient care. The investigators have developed numerous methods for the accurate interrogation of cancer genomes that overcome challenges associated with clinical samples and the genetic variability resulting from tumor evolution. In this endeavor, Droplet Digital PCR is one of their chief tools.
"Droplet Digital PCR has accelerated our discoveries," said Dr. Ji. "Given its ease of use, superior performance in terms of accuracy, and rapid development time for novel assays, Droplet Digital PCR has repeatedly demonstrated its vast utility and potential for future diagnostic application."
Dr. Ji recently gave a talk on using ddPCR technology to track the presence, expansion, and disappearance of pathogenic genetic variants in cancer, infectious diseases, and other human diseases over time, and also discussed the technology's potential for highly informative diagnostics. He now uses Bio-Rad's recently launched second-generation ddPCR instrument, the QX200™ Droplet Digital PCR system, the only digital PCR system that works with both DNA-binding dye and TaqMan probe chemistries.
The QX100™ system boasts a lineup of prestigious users including:
- Jim Huggett,the author of the digital MIQE (dMIQE) guidelines and a scientist at LGC (the UK's designated National Measurement Institute for chemical and bioanalytical measurement)
- David Dodd of the University of Texas, Southwestern
- Leonardo Pinheiro of Australia's National Measurement Institute
- Ross Haynes of the U.S. National Institute of Standards and Technology
- Vicki Hwang of the University of California, Davis
- Alec Morley of Flinders University and co-author of the first paper to use digital PCR
- Keith Jerome of the University of Washington
- Gary Lee of Sangamo BioSciences
- Sabita Sankar of MolecularMD
- Donna Sullivan of the University of Mississippi Medical Center
There are also a number of emerging applications using ddPCR technology including microRNAs, single-cell gene expression, gene linkage, multiplexing, EvaGreen applications, and validating next-generation sequencing data.
For more information on the QX200 Droplet Digital PCR system, visit www.bio-rad.com/QX200.
To view Bio-Rad's six-part webinar series on Droplet Digital PCR and the complete list of Droplet Digital PCR system publications, visit http://www.bio-rad.com/ddPCR-Webinars.
Bio-Rad's Droplet Digital PCR Highlighted at ASHG Annual Meeting:: Posted by American Biotechnologist on 10-22-2013
More accurate and precise assessment of copy number variation (CNV), the number of copies of a particular gene that are present in a genome, may lead to improved diagnosis and therapy for cancer and other diseases including autoimmune disorders. However, current technologies to determine copy number can be inaccurate, labor intensive, or prohibitively costly, diminishing their effectiveness in clinical applications.
Using Bio-Rad Laboratories' Droplet Digital PCR (ddPCR™) technology, researchers can rapidly, accurately, and economically determine copy number states. Groups from the University of California, Davis, and the University of Colorado School of Medicine, among others, will present promising new research results at this year's annual meeting of the American Society of Human Genetics (ASHG), held in Boston from October 22-25, 2013.
"Since its introduction in 2011, Bio-Rad Laboratory's ddPCR technology has demonstrated the potential to be a transformative technology based on its greater precision, reproducibility, and sensitivity than conventional approaches such as real-time PCR," said George Karlin-Neumann, the scientific affairs director at Bio-Rad's Digital Biology Center.
Less than two years since Bio-Rad brought digital PCR systems to the market, studies using ddPCR assays have resulted in nearly 50 peer-reviewed publications.
Using ddPCR to Improve Pediatric Care
One example of how CNV determination with ddPCR technology shows promise for clinical applications is newborn CNV screening. 22q11.2 Deletion Syndrome (22q11DS) is the most common microdeletion syndrome in humans and is associated with more than 100 different diagnostic findings including craniofacial defects, developmental delay, and autism spectrum disorders. Researchers in Dr. Flora Tassone's lab at the University of California, Davis have developed an inexpensive, rapid, sensitive, and specific alternative to fluorescent in-situ hybridization (FISH) – the currently accepted diagnostic tool – using ddPCR technology to identify newborns with 22q11DS. At the ASHG meeting, they will demonstrate for the first time the efficacy of ddPCR in large population screening studies (Program Number 2590F).
Researchers on Dr. James Sikela's team at the University of Colorado School of Medicine are investigating DUF1220 copy number reduction and its association with microcephaly, a neurodevelopment disorder related to pediatric brain size. They will demonstrate how ddPCR is an effective technique for determining copy numbers of highly duplicated sequences such as DUF1220 and how ddPCR may be used for similar studies in future research where array comparative genomic hybridization (aCGH) analysis or qPCR are not accurate enough (Program Number 3215F).
In addition to the research findings described above, Bio-Rad's ddPCR technology will be showcased in 11 other presentations. For more information, visit Bio-Rad's booth at ASHG (booth #839). Bio-Rad will also be hosting an ASHG lunch workshop on Thursday, October 24 at 12:30 PM in room 211 as well as a hospitality suite on Thursday, October 24 at 7:45 PM at the New England Aquarium, 1 Central Wharf in Boston, featuring presentations from UC Davis and Harvard Medical School researchers. Please visit booth #839 for further details.


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Inexpensive Fun
Surprisingly affordable and fun, these value-priced rides stimulate your well-being and your bank balance.
By May 27, 2009 / Photos by Jay K. McNally
It has been said that money can't buy you happiness. But in the case of the five cars featured here, money can indeed buy more than happiness it can buy a set of wheels guaranteed to put a smile on your face by being both inexpensive and fun to drive.
Most of the cars in this group feature a base price of less than $19,000, and they come in a wide variety of configurations: as a sedan or coupe (), a compact SUV (), an all-wheel-drive sedan or 5-door () and a pair of attractive, sporty 5-doors ( and ).
2009 Honda Fit Sport (MSRP $16,260)
In the minds of many, a 5-door (once upon a time known as "a wagon") can be efficient and/or practical...but not fun. But roomy little runabout turns this notion on its ear. And thanks to a recent restyling, the Fit looks even more sporting with its more aggressive and pointy proboscis.
Though its 4-cylinder engine makes only 117 horsepower, the Fit has a peppy, rev-happy nature, crisp steering and a smooth-shifting 5-speed manual transmission. Even the suspension is tuned to have a sporty feel. The Sport model has some welcome additional features, including a body kit (with a roofline spoiler), sharp-looking 16-in. alloy wheels and a USB audio interface. And on the safety front, there are front and side airbags, along with active front head restraints that help minimize whiplash for the driver and front passenger in the event of a rear-end collision.
Five Reasons to Buy:
1. Even more fun than it looks
2. Space efficiency
3. Thrifty fuel economy
4. Nice-looking 5-door
5. Clean interior
2009 Subaru Impreza 2.5i (MSRP $17,995)
With a starting price under $18,000, the sport sedan (also available as a 5-door for only $500 more) is a very good deal on the surface. But delve a little deeper into its window sticker and factor in the standard all-wheel-drive and unique flat-4-cylinder engine and this Subie becomes an exceptional deal.
has been equipping its cars with full-time all-wheel-drive for years, and it is a strategy that has worked well for this Japanese manufacturer not only has this helped differentiate the company from the likes of // but it has helped Subaru earn a near cult-like following in the snow country from Colorado to the Northeast.
As for the aforementioned "flat" engine, this means that the cylinders/pistons are horizontal, a design favored by for decades.
When the weather gets bad, the all-wheel-drive starts to shine, capable of getting places that other cars can't, and doing it at a bargain price.
Five Reasons to Buy:
1. All-wheel-drive versatility
2. All-wheel-drive fun
3. Low base price
4. Peppy engine
5. Reputation for reliability


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Bald Rock
Bald Rock is a 4,012 ft / 1,223 m mountain peak near Whitefish, Montana, United States. Based on peakery data, it ranks as the 2677th highest mountain in Montana and the 30312th highest mountain in the United States. The nearest peaks are Bald Mountain, Sheepherder Hill, Boorman Peak, Pilot Knob, Tally Mountain, and Ashley Mountain. See the Bald Rock map, 3D fly around, and the Bald Rock photos to get a better sense of the mountain.
Photos provided by Panoramio are under the copyright of their owners.
Bald Rock SUMMIT LOG claim the peakery first ascent!
No one has reported climbing or hiking to Bald Rock summit on peakery. If you've climbed this peak be the first to report it! Share your summit log entry and add Bald Rock pictures from your climb below. Include the names of the routes or trails you took to the summit and back.
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4,012 ft / 1,223 m
ProminenceHeight Rank
#2678 in Montana
#30341 in United States
Summited by
3d Fly AroundShow Bigger »
Nearest peaks see on map »
- Monte Rosa 2,510 ft / 765 m 0 mi / 1 km away
- Mount Monadnock 3,165 ft / 965 m 1 mi / 1 km away
- Dublin Peak 3,041 ft / 927 m 1 mi / 1 km away
- Town Line Peak 2,884 ft / 879 m 1 mi / 2 km away
- Bigelow Hill 1,549 ft / 472 m 2 mi / 4 km away
- Gap Mountain North Summit 1,821 ft / 555 m 3 mi / 4 km away


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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"Although the picture I ultimately chose was a little dark on the finished product, I love the magnet! The entire theme fits with our wedding style."
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Thor Tower
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bubble and unicorns
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rise of antares
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Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. Part 1 of a 2-part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS. Part 1 focuses...
Discuss the article on the Forums.
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I changed from shopping at other Magic sites because of MJM's great price and free shipping.
I only buy Magic from this site now because they...Read More ->


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CNN's Sara Sidner and a media lawyer explain what it's like to cover Ferguson; big-name anchors are secretly meeting with Darren Wilson; Bill Cosby pressures an AP reporter.
NBC gets an exclusive on the Obama administration's drone policy, which escapes the attention of Bill O'Reilly and Doonesbury takes a stand for newspapers.
Topic for discussion:
Why no coverage by the media of the stunning testimony of Panetta and Dempsey this week which revealed that Mr. Obama and Mrs. Clinton were missing in action during the Benghazi terror attack? And that Panetta and dempsey knew on day 1 that it was a terror attack, but apparently the president didn't for 3 weeks (despite candy Crowley trying to come to his aid during the debates)?


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Cincinnati Children's Hospital Medical Center
Widespread vaccination of adolescents for pertussis was associated with lower rates of infant hospitalizations for the respiratory infection than would have been expected had teens not been inoculated according to new research in Pediatrics.
Reporting their results online Oct. 21, researchers said the study underscores the importance of increasing vaccination rates among teens and adults to stem an ongoing pertussis epidemic among infants. The research was conducted by physicians at Cincinnati Children's Hospital Medical Center and the University of Michigan.
The ongoing epidemic has been linked to waning immunity and the failure to vaccinate, according to Katherine A. Auger, MD, MSc, the study's lead author and a pediatrician in Division of Hospital Medicine at Cincinnati Children's.
"We know infants get pertussis from family members, including older siblings," Auger said. "While it is encouraging to find a modest reduction in infant hospitalizations after the vaccination of adolescents began, there were still more than 1,000 infants hospitalized for pertussis in 2011. Expecting parents should discuss with their doctors the need for vaccination of all caregivers before the birth of a baby."
The current study was initiated following recommendations by the Centers for Disease Control in 2006 to vaccinate all adolescents against pertussis. Researchers used data from the Nationwide Inpatient Sample, a database maintained by the U.S. Agency for Healthcare Research and Quality.
Investigators examined pertussis hospitalization rates for infants after the new adolescent vaccine recommendations were made and compared them to predicted hospitalization rates had adolescent vaccinations not been implemented. Hospitalization data from 2000 to 2005 – prior to the teen vaccination recommendations – were used to predict hospitalization rates had adolescent vaccinations not been implemented.
In three of the four years examined after the teen vaccination recommendations (2008-2011), investigators found lower hospitalization rates for infants than would have been expected with no adolescent vaccinations.
In 2011 for example, the expected hospitalization rate for pertussis if adolescent vaccinations had not been implemented was 12 hospitalizations per 10,000 infants. The observed rate following the teen vaccinations was significantly lower at 3.27 hospitalizations per 10,000 infants.
Pregnant women should receive pertussis vaccination during pregnancy, according to a recommendation made by the Centers for Disease Control in 2012. Auger said future research will be needed to assess how and if this policy change further affects pertussis hospitalization rates in infants.
Study authors received funding from the Robert Wood Johnson Foundation through the Clinical Scholars program.
Cincinnati Children's Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S.News and World Report's 2013 Best Children's Hospitals ranking. It is ranked #1 for cancer and in the top 10 for nine of 10 pediatric specialties. Cincinnati Children's is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at www.cincinnatichildrens.org. Connect on the Cincinnati Children's blog, via Facebook and on Twitter.
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Researchers have successfully targeted an important molecular pathway that fuels a variety of cancers and related developmental syndromes called "Rasopathies." Reporting their results Nov. 20 in Chemistry & Biology, scientists at Cincinnati Children's Hospital Medical Center say they identified a class of lead compounds that successfully recognize a key target in the Ras signaling pathway – opening the door to future development of therapies that could make treatments more effective with fewer side effects.
Conclusive data show that hydroxyurea therapy offers safe and effective disease management of sickle cell anemia (SCA) and reduces the risk of stroke, prompting early termination by the National Heart Lung and Blood Institute (NHLBI) of a key clinical trial studying the drug's efficacy. NHLBI officials issued the announcement today, about one year before the study was originally scheduled to end. The study was led by Cincinnati Children's and Principal Investigator Russell Ware, MD, director of Hematology at the medical center.
The sound of monitor alarms in hospitals can save patients' lives, but the frequency with which the monitors go off can also lead to "alarm fatigue," in which caregivers become densensitized to the ubiquitous beeping.
Cincinnati Children's Hospital Medical Center has opened its newest urgent care center at the hospital's Liberty Campus, located on Yankee Road. This represents a continued commitment from the medical center to provide care to Greater Cincinnati's pediatric population.
A study to be released in the November issue of Health Affairs shows that integrating community housing data on such code violations as mold and cockroaches with health data can identify at-risk geographical areas of medical concern and help target patients for medical interventions.
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Feb 17, 2014
CAIRO [MENL] -- Al Qaida has been targeting tourists in Egypt's turbulentSinai Peninsula.
Nov 04, 2013
NICOSIA [MENL] -- Iran has launched a dual-use submarine.
Nov 02, 2013
CAIRO [MENL] -- Tunisia has been placed on alert for Al Qaida bombings.
Oct 31, 2013
CAIRO [MENL] -- Egypt, on the eve of the European season, has reportedimproved security for tourists in the Sinai Peninsula.


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|Hospital Quality
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Key things you need to know aboutDr. First:
Dr. First's Experience
Research training, expertise and qualifications
Dr. First's Specialties
- Sports Medicine
- View 1 specialty and 2 board certifications
Procedures Dr. First Performs
- ACL (Anterior Cruciate Ligament) Surgery
- Carpal Tunnel Release
- See all 20 procedures
Conditions Dr. First Treats
- Achilles Tendinitis
- Ankle Sprain and Achilles Tendon Sprain or Rupture
- See all 55 conditions
More About Dr. First's Background
Today in Pain Management
Hospital Quality
The right hospital is as important as the right doctor
- CHRISTUS Saint John Hospital
- 18300 Saint John Drive
- Houston, TX 77058
9 Facts About Hospital Quality
Patients' risk of dying during a hospital stay for heart bypass surgery could be 85.2% lower, on average, at a hospital rated 5 stars compared to a hospital rated 1 star for that procedure. Choosing the right hospital is critical to your health. View Slideshow
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Likelihood of recommending Dr. First to family and friends is 4.2 out of 5 5 1 29
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8 Facts About Patient Satisfaction Surveys
Patient satisfaction surveys provide a standardized way of reporting about healthcare experiences. But there can be more than meets the eye when reviewing scores. Here's what you should know
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Office Space To Rent In Trenton NJ
Office Space Prices and Amenities: This is just about the best time in years to lease new Trenton executive office suites. Commercial office space is very reasonably priced right now, making this a great time to rent new office space and grow your business. These premium office centers are available in a variety of sizes and lease options, and are perfect for any business or company.