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Diseaseless System Cold sores usually go away without any medication in about a week to ten days. Many people choose to wait for their cold sores, just ignore them until they disappear. Others decide to ten days is too long to have a great facial pain,, shameful defect near your mouth and look medications or other treatments to make the cold easier to treat pain. There are many different types of cold sore treatment available, from antiviral pills over the counter creams and prescription sale. Many people also use conventional painkillers like aspirin and acetaminophen for the treatment of herpes labialis.
People suffering its first outbreak of cold sores, are recommended to take antiviral medications. These pills are available only by prescription, so the cold sore sufferer should consult a doctor first. Cold sore medication such as acyclovir or famciclovir can relieve pain and reduce healing time of cold sores. Antiviral drugs are most effective when people start taking it when cold sores first appears.
Several types of creams which are used to treat cold sores. Creams containing docosanol are particularly useful. Docosanol used to fight the HSV-1 virus that causes cold sores and can relive pain and help heal cold sores before. Other types of treatment of cold sores include creams designed to numb the area around the wound and moisturizer cold creams that help revitalize the skin around the mouth ulcer. Lip balm can prevent cold sores from cracking open. https://www.linkedin.com/today/post/article/20141001062043-146919720-dr-patel-s-diseaseless-system-review-free-book-download
Many conventional medications to relieve pain such as acetaminophen, aspirin and ibuprofen are excellent treatments for cold sores. These drugs treat inflammation, pain relief. While there is no cure for cold sores, there are several types of treatment for cold sores that make having a cold sore more bearable shorter experience.


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Tech Posts
B.A.B.E, the biggest Steampunk gun shoots smokeMay 6, 2013 By Buddy
Ecoxpower charges your Smartphone and shows you way ahead at the same timeAugust 22, 2012 By Buddy
A Solar-Powered unmanned aircraft can fly all day long but comes with an extreme price tagAugust 17, 2012 By Buddy
The Spine Robot is a real life Dr. Octopus arm and is powered by hydraulicsAugust 14, 2012 By Buddy
"Urban Rough Sleepers" Backpack transforms into a shelter to keep you cozyJuly 12, 2013 By Buddy
Striking portable SNES mod is shock proof and holds 10 hrs battery backup
Modding can do miracles. We've seen a lot of mods related to gaming but this portable SNES might be the simplest yet the best one ever. The portable SNES mod has been made by a redditor known as robotairz. Yes, it's an SNES mod, not so common piece of gaming these days but the popularity and craze of this gaming console led the modder create it with elegance.
robotairz created the case last year but shared his creation on Reddit yesterday. The portable SNES is a yellow mod that comprises of a shock proof interior and a solid carry case. It is powered by six 3.7v 5000mAh li-po batteries and can be plugged in for charging via an inbuilt charger. One charge can hold more than 10 hours of gaming. It also has an 8" LCD with a resolution of 800×600.
All of it took him about $425 in the built. Another redditor offered him $900 for the console but he rejected the offer as he is not willing to sell it.

subset: commoncrawl


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July 02, 2014 3:51 PM
Francis Mutua has been a wood craftsman for years. But today, the Kenyan artist is working with a much softer material -- plastic flip-flops.
And as he cuts and glues the raw materials and recycles them into whimsical animal sculptures, he's also cleaning up his nation's coastline.
Tens of thousands of plastic sandals are collected each year by the non-profit environmental group called Ocean Sole. The discarded flip-flops wash up on Kenya's beaches and are tossed out in its poor neighborhoods.
"In the slums, people use a lot of sandals," said Mutua. "When they are finished, they discard them. There are people who walk and collect them and bring them to the compound."
At the Ocean Sole workshop in Nairobi, the sandals are turned into eye-catching art by Mutua and 50 other artisans.
Ocean Sole was founded in 1997 by Kenyan conservationist Julie Church, who sees the project as a way to promote change in how people live.
"Being able to impact people through training, education and awareness in a much greater level -- right now we're just dealing with the clean-up," said Church. "If we get more people involved in cleaning up their act, I think we can do something."
Workers collect the washed-up flip-flops and bring them to Ocean Sole's headquarters to be cleaned and sorted. There, they are glued together, sanded and given new life.
Ocean Sole brought Mutua and several other artisans to Washington DC for the annual Smithsonian Folklife Festival, to demonstrate their craft and spread their environmental message.
As he displays his work, Mutua said Ocean Sole has changed his life - and his country - in ways he did not expect.
"The difference made by these," he said, "we are saving the environment."
Avery Sunshine is known for her irresistible combination of soul, jazz and gospel influences. She's traveled the world entertaining audiences with her powerful voice, inspiring lyrics and infectious spirit. She joins host Shawna Renee on "The Soul Lounge" to perform and share the stories behind her new album, "The Sun Room."


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Ledaig 10 Year Old
Back to Products
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750ml Bottle $284.94
Case of 6
750ml Bottle $284.94
Case of 6
Item #61414
Size: 750ml
Type: Scotch
Varietal: Single Malt
Country: Scotland
Region: Mull
Proof: 92
Prices, promotions and availability may vary by store and online.
Glengoyne 10 Year Old
"Nose: A fresh but very soft, warm fruitiness, with hints of smoke and sherry. Body: Light to medium, smooth, rounded. Palate: Clean, sweetish, tasty, very pleasant. Finish: Still sweet, but drying slightly. Clean, appetizing."
$39.99 / 750ml Bottle
$227.94 / Case of 6
$227.94 / Case of 6
Tobermory 10 Year Old
A complex gem from the only distillery on the Isle of Mull. Soft, yet rich, with a rounded fill that belies it's age, this is a great eveyday whisky.
$49.99 / 750ml Bottle
$284.94 / Case of 6
$284.94 / Case of 6
Laphroaig Triple Wood Islay Single Malt
Similar to Laphroaig Quarter Cask, but also finished in oloroso sherry casks. Fruit and smoke: fleshy red berries, red licorice, toffee, ripe barley, coal tar, sun-baked seaweed, peat smoke, and a hint of coffee grounds. Tarry finish. I rated the Quarter Cask a 91, and I think this whisky is in the same ballpark. If you like sherry-influenced whiskies, then go for the Triple Wood. If not, then consider the Quarter Cask.
$59.99 / 750ml Bottle
$341.94 / Case of 6
$341.94 / Case of 6
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Department of Homeland Security, Bureau of Customs and Border Protection: Required Advance Electronic Presentation of Cargo Information, GAO-04-319R, B-293424, December 18, 2003
B-293424: Dec 18, 2003
Additional Materials:
(202) 512-2853
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This is our report on a major rule promulgated by the Department of Homeland Security. It was published in the Federal Register as a final rule on December 5. Information pertaining to cargo before it is either brought into or sent from the United States by any mode of commercial transportation. The cargo information required is that which is reasonably necessary to enable high-risk shipments to be identified for purposes of ensuring cargo safety and security and preventing smuggling pursuant to the laws enforced and administered by CBP. Whichever is later. 5 U.S.C. 801(a)(3)(A). As the rule was published in the Federal Register on December 5. It does not have the required 60-day delay in its effective date for congressional review.
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Oct 23, 2013 12:21 PM by Ian Auzenne
A contract worker is dead following a jobsite accident Tuesday at the Port of West St. Mary.
Sheriff's deputies received the call around 4:15 P. M. about a medical emergency at the port.
Port executive director David Allain says the victim was working on the roof of a building that the port rents when he fell.
Allain refused further comment about the incident pending an ongoing investigation into the accident by the port and other agencies.
3 hours ago


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featured »
Opportunities to take part in Centennial events
Share The Winston-Salem Centennial Commission is making the Centennial website available to residents and organizations to share their centennial events and memories. Any organization that is having a centennial-related event can have information aboutRead More »
Q & A with hometown legend
Share Carl Eller's life as a legendary football player is well-documented, and he's enshrined in nearly everybody's Hall of Fame (college and pro). Recently, the man they call "Moose," came home to Winston-Salem toRead More »
Column: Can We All Just Get Along?
Share I never considered the late Rodney King anything of a philosopher, but as one observes Washington shenanigans, especially around fiscal matters, it seems that Brother King had a point. Can we all just,Read More »
Library to host 'Muslim Journeys'
Share "Muslim Journeys," a series of programs slated to be held next month in the Central Library Auditorium, will support the Muslim Journeys Bookshelf, a collection of 25 books and three DVDs awarded toRead More »
Diggs-Latham hosts black history extravaganza
Share Black History Month at Diggs-Latham Elementary Magnet School for Arts and Global Studies ended with a culminating celebration of speeches, singing and dancing. Community members, Winston-Salem/Forsyth County Schools Central Office personnel, business partners,Read More »
WSSU to use grant to help aspiring entrepreneurs
Share A $40,000 grant from the DataMax Foundation will support efforts by the Center for Entrepreneurship (CFE) at Winston-Salem State University's School of Business and Economics to encourage new businesses as part of itsRead More »
Clean-Up Crew
Share Volunteers help tidy city Volunteers came out in force in support of the Great American Cleanup effort in Winston-Salem on Saturday. Nearly 700 residents took part in the annual event, part of aRead More »


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- Fri
- Nov 28, 2014
- Updated: 12:23am
Solo adventure
PUBLISHED : Wednesday, 05 May, 1993, 12:00am
UPDATED : Wednesday, 05 May, 1993, 12:00am
Most Popular
YACHTSMAN Terence Lam has steered his way through the first stage of his solo round-the-world voyage. Nearly one month into his three-year adventure, Lam has reached Palawan in the Philippines.
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Two postgrad students seeking general day-to-day jobs
Hello! We are two reliable and trustworthy [female] postgraduates who are simply looking to fill some time before moving back up to Edinburgh at the start of December. We are most experienced in the hospitality industry but would consider a ra
Dumfries, Dumfries and Galloway11 days ago


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iPhone Dev Team, the creators of the first iPhone 4 jailbreak, has said it will not be supporting its jailbreak and has chosen to back out of the 'cat and mouse' game with Apple.
The original hack was released mere weeks after the release of Apple's iPhone 4 and gained immense popularity for being an alarmingly simple process. Users could jailbreak their iPhone simply by visiting a website.
Dev-Team has confirmed that it will not be providing an updated version of the jailbreak for the new 4.0.2 firmware, which Apple released to counter the hack.
A post on the Dev-Team blog congratulated users who were able to jailbreak their iPhone but also revealed the team wouldn't butt heads with Apple any longer.
"FW 4.0.2/3.2.2 was *only* released to fix the jailbreakme hole," the team said. "With FW 4.1 still in its beta stages, it makes no sense to escalate the "cat & mouse" with Apple for FW updates that only fix the jailbreak holes. To quote WOPR, "the only winning move is not to play."
The team indicated that continuing the development process this early in the beta firmware period would only benefit Apple.
"If the cat & mouse game escalates too quickly, especially during beta FW periods, nobody but Apple benefits. For this reason, there won't be a 4.0.2/3.2.2 jailbreak specifically during the period where 4.0.2/3.2.2 is the latest public release," it said.
A jailbreak for the PlayStation 3 also recently made its way to the internet.


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Anchor Steam is ranked on:
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Beers with 4.9 Percent Alcohol ContentOct 18 2014
List of beers with 4.9 percent alcohol content, sorted alphabetically with photos when available. This li...more
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The Best Domestic Beersvote on it! Oct 18 2014
This list features the best domestic beers, ranked by the beer loving community. There's nothing better t...more


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Interesting Facts About A$AP Rocky. Named after rapper Rakim (of Eric B. & Rakim fame); Started rapping at 8. Childhood: Born in the crime-infested Harlem ...
A$AP Rocky Goldie Review - Rap/Hip-Hop - About.com
Like any rap rocket, A$AP Rocky is hit-driven. And so he's kicked off his rap career with hit after hit, none of them like anything you'd expect from a Harlem rapper ...
ASAP Rocky - Interview - Rap/Hip-Hop - About.com
He's the most exciting new voice in rap. A$AP Rocky has also inspired a good dose of vitriol for adopting elements of Houston hip-hop in his music.
A$AP Rocky - 'Long Live A$AP' (RCA) - Rap/Hip-Hop - About.com
Jan 15, 2013 ... A$AP Rocky writes his own formula on Long Live ASAP.
10 Rappers to Watch in 2012: A$AP Rocky - Rap/Hip-Hop - About.com
He invokes the spirit of UGK, name checks Harlem, and tips his hat to OutKast on the cover of LiveLoveA$AP. Rocky represents a new rank of rappers with no ...
Top 10 New Rap Albums for March - Rap/Hip-Hop - About.com
A$AP Mob has been putting in "Work" lately. The crew hit it big with A$AP Rocky and A$AP Ferg last year, and they look to keep the momentum going with the ...
Top 10 New Rap Albums for October - Rap/Hip-Hop - About.com
The guest list is a weird one: Purity Ring, Freddie Gibbs, Scrufizzer, Charli XCX, A$AP Rocky. Paul White and SKYWLKR handle most of the production. Not.
Drake - "Hold on, We're Going Home" - Rap/Hip-Hop - About.com
There are certain styles only a few artists can pull off. Kanye West rocks skirts and leather pants. A$AP Rocky favors nail polish. And there was a time when all of ...
Top 10 Rap Songs for April 1, 2012 - Rap/Hip-Hop - About.com
Apr 1, 2012 ... Now Plies, an unlikely candidate for a saturnine soundtrack, offers up his ... A$AP Rocky's three-headed monster of a response to critics who ...
Top 50 Rap Songs of 2012: #50 - 41 - Rap/Hip-Hop - About.com
Juicy J - "Bandz a Make Her Dance" (Ft. Lil Wayne and 2 Chainz). Now this is ... " F**kin' Problems" is A$AP Rocky's idea of a wink: Drake as a zany playboy?


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Wanderlust Trailer: Jennifer Aniston and Paul Rudd Live on a Communeby Free Britney at . Comments
With her turn in Horrible Bosses earlier this year, Jennifer Aniston likely made a lot of people reevaluate the American sweetheart/mediocre romantic comedy persona she's cultivated (or been burdened by) over the years.
Wanderlust further helps her break that mold in hilarious fashion.
Jen and Paul Rudd play a couple who exit the city and take refuge in the country within a community that is ... shall we say, socially liberal. Watch the trailer:
Their new community/commune home is filled with people who embrace a free-spirited mentality when it comes to jobs, relationships, clothes ... you name it.
Produced by Judd Apatow, Wanderlust is also notable as the film where Jen met Justin Theroux, who co-stars in the film and is now her live-in boyfriend.
It comes out February 24.
Very ordinary house, and it doesn't look like it's in Beverly Hills. It looks like just antehor home in the Valley- South of the Boulevard. It must just have a Beverly Hills zip code, way to plain, just like Jen.
Paige, what is your problem? Haven't you dated anyone ever? Married the first man you met? Is three boyfriend in 5 years too much, five a scandal for a free single woman? Please let us (and Jennifer) know the exact number and other rules you set us. Let us know how often we must change our hair too even if we liked our present style..
Paige - in 7 years! Jen actually dated and had the norm of relationship like a regular person! When Jen's marriage ended she was still in love with her husband! Maybe you should be talking about George, Gerard, Sandra, Renee, and many other stars and people you know! or brad, jolie look at their records....... and jolie herself has said they have an open relationship - so how many people have they been with? we don't know! and i don't care! strange how lightly we don't mind calling a person an unkind name without looking at the big picture just because we like another star. sad. move on!
Jen is one classy lady! Awesome! The movie looks fun! Justin is so hot! Jen and Paul look like they could be a real couple - great chemistry! I love Jen and Justin! Justjen! I will be there to see Wanderlust on day ONE!
I dont see this relationship lasting. She's a whore after brad dumped her she just went from man to man. Vince,paul,john am i missing anyone? Try a new hair style and a movie role jen.


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How To Protect Your Relationship From Holiday Drama view
9 Ways to Balance Success and Finding Love view
10 Smart Habits Of Happy Couples view
Photo Credit: Getty Images
The summer nights never end in Las Vegas, which makes it the ideal escape for any couple...
The summer nights never end in Las Vegas, which makes it the ideal escape for any couple looking for a vacation filled with long laughs, great fun and a string of unforgettable nights. You know what they say: "What happens in Vegas, stays in Vegas." So, don't you think it's high time you two booked your stay there?
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Thursday 15 November 2012 Updated: 21/12 08:46
STRATFORD District Council are to take the government to court over plans to build 800 homes in Shottery.
Councillors voted on Thursday (November 15) in favour of challenging the green-light given by Secretary of State for Communities Eric Pickles in the face of almost unanimous local opposition, including the district council, Shakespeare Birthplace Trust, and Stratford MP Nadhim Zahawi.
Coun Chris Williams, Chairman of Regulatory Committee, said: "The committee was unanimous in its decision, showing full support for the course of action."
Mr Pickles announced his decision to approve an appeal by JS Bloor Homes to build the huge development on land near Anne Hathaway's Cottage.
The planning application by JS Bloor Homes and Hallam Land Management for up to 800 new homes, a new primary school, health centre and local shops was originally rejected by the district council in 2011. Further to an appeal held earlier this year, the Secretary of State decided planning permission should be granted.
The council will now contest the decision based on legal advice.
Council leader Coun Chris Saint, said: "I was pleased that a unanimous decision was made that reflected the many representations I have received."
2 Stratford on Avon man jailed for raping prostitute
3 More to Christmas Truce than football
4 Gold curtain up at Holy Trinity Church in Stratford on Avon
5 Lottery win for Stratford-on-Avon couple
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MAKING Stratford a million times better is the
GOLDEN boy James Roe has topped off a
THE DEVASTATED family of a teenager who died
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HOMES and businesses in the town centre have been affected ...
A FOUR car smash on the M40 caused gridlock on ...
Visit the Worcester Observer website for the latest.


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Eighty years ago, on April 4, 1930, the Hughson Union High nine nosed out the local Manteca High Buffaloes and won the third C.I.F. game of the season by a 12 to 11 game in Hughson. The Hughson boys were hitting the ball quite regularly, getting six runs off Fred Theiler and six off Joe Abreu, who pitched for the Mantecans. They pitched fairly good ball but were given little support in the field. In the sixth frame, the Mantecans started a rally and scored eight runs before they could be stopped. Theiler and Joe Bettencourt got three ...
I told a former student that it's important to be passionate about something other than your career, so in case work goes bad, or the exuberance with which you jumped into said career wanes, you're not left with nothing.
Seventy years ago, on March 28, 1940, in a wild and wooly game that saw both nines score at will, the Manteca High hickory stickers finally came through with a close 12-11 win over their rivals from Tracy High. The lead changed hands several times at the outset of the game and both pitchers were hit unmercifully. "Frenchy" Guisto poked out a pair of four-ply swats besides gathering a triple and two singles for a perfect day at the plate. It was the only sporting event that came to a head over the past week. All other scheduled events were ...
It may sound odd, but 19-year-old Mantecan Jake Commeau's ultimate goal is to play Division-I ice hockey for a four-year university.
As the water temperatures continue to rise, local fishing is only going to continue to get better.
Though I didn't have a plan, there was little doubt I would end up spending Saturday fly-casting.
Fifty years ago, on March 25, 1960, Manteca High, for the second time this season, knocked a club out of the unbeaten ranks by knocking off the powerful St. Mary's High Rams 8-1. It was the Rams' first loss in six games. Walt McDonald pitched the first six frames for the Buffaloes and was credited with the win. McDonald and reliever Wes Holbrook limited the Rams to two base hits. Tim Brumley, with a double and a home run and Wade Richards with two singles, led the locals in the hitting column.
The entire buzz this week has been about the 18.11-pound bass that was recently caught and released by Kyle Gentry of Oakdale.
DUBLIN - Manteca Futbol Club's under-14 girls Arsenal was eight minutes away from calling it a season during its NorCal Premier State Cup Final 16 match against No. 3 seed Dublin Fury Sunday at Emerald Glen Park.
Saturday evening was almost the perfect meal, well, as perfect as one can be without mom's crab rolls or eating trout and salmon riverside minutes after its been hooked and clubbed.
Jacob Souza produced a gem to remember for the Spreckels Park Major Division A's on Opening Day Saturday, leading a 4-0 shutout of the Indians.
Manteca Bowl
The Ripon Chiefs varsity got on the board first Saturday in the opening round of the Motherlode Valley Football League playoffs against the Hughson Huskies but could not pull off the win in a 32-8 loss to the Huskies.
In opening-round action of the Trans-Valley Youth Football League the Ripon Knights junior varsity avenged a regular-season loss to the Modesto Christian Kingsmen with a convincing 25-8 win.
The Manteca Jr. Timberwolves varsity remained undefeated in conference play and sewed up the No. 1 seed in upcoming Delta Youth Football League playoffs with a 39-22 victory over the host Dublin Fighting Irish.
The Ripon Knights used a balanced and pounding attack to defeat the Denair Lions 40-8 on Saturday at Ripon Christian High School to sew up the first seed and an opening-round bye in the upcoming Trans-Valley Youth Football League playoffs.
Angel Garay ran for 116 yards and three touchdowns to lead the Manteca Jaguars varsity to a 38-8 win over the Merced Bears in Cen-Cal action.
Manteca Bowl
The Ripon Chiefs varsity got on the board first Saturday, but that was not enough as the undefeated Escalon Outlaws battled back to win 28-8 in the Motherlode Valley Football League regular-season finale.
East Union is showing signs of peaking at just the right time.
Chelsea Gray was destined to assist others, whether by pass or by lesson. The former Brock Elliott Elementary School student has succeeded at basketball's highest levels, winning state championships at
The varsity Ripon Chiefs burned the Riverbank Raiders with a balanced attack in their final home game of the regular season and rolled to a 38-9 Motherlode Valley Football League victory.
Manteca Jr. Timberwolves safety Tarnjot Singh saved his team's 14-6 win over the Manteca Chargers with a late-game interception and set up the first Jr. Timberwolves score with an interception on Saturday in varsity Delta Youth Football action at Dino Cunial Field.
Angel Garay returned a punt 70 yards for a touchdown and added two more scores to lead the Manteca Jaguars varsity to a 32-6 win over the Atwater Falcons in Cen-Cal action.
The Manteca Cowboys wrapped up the DYSA regular-season campaign undefeated with a 44-0 shellacking of the Atwater Falcons
The Modesto Christian Kingsmen junior varsity downed the Ripon Knights 14-6 in Trans-Valley Youth Football League action.


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Pool party foods to sit at ambient temperature
- Bada Bing Jul 2, 2010 09:52 AM
Any great ideas for main or side dishes to bring to my neighbor's July 4 pool party? The format is that we show up about 4pm, and food sits in the shade of the garage while people pick away at it for quite some time (couple of hours). It'll be 90 degrees (C32) out. I already know that someone's bringing a Mac & Cheese and another is bringing baked beans.
In the past, I brought a quiche one year, a Turkish-style green bean salad another year, and then a delightful and simple dish of cooked dried beans (in case you wonder, cannellini cooked in flavorful broth, then well drained and served mixed with diced roasted peppers, minced herbs, S&P, and best-quality olive oil).
While those were all successes, I bet there are great other ideas around here. Thanks in advance!
i'll give you the same suggestions i had for another Hound who needed ideas for a potluck dish:
- charred corn salad inspired by elote (Mexican grilled corn)
- German potato salad
- non-traditional guacamole...there are a zillion ways to get creative with it
- gazpacho (traditional, white grape & almond, avocado...)
BTW, the "shade" of the garage doesn't sound sufficient to me to keep things cool. i hope the hosts are planning to set up some ice baths!
I make a great greek salad with chopped fresh cucumber (salted for 30 mins, drained and rinsed), chopped red onion, fresh tomatoes and feta cheese with mint and parsley and a light olive oil and red wine vinegar dressing. Corn salad is alsoa great idea. If you want to do a main dish, maybe go for pulled pork done in the crock pot over night.
re: jenhen2
Great ideas so far!
I think I grasp how to approach all of these except the charred corn salad. Any tips there? (I googled and ended up with some very different recipes, many to be served as salsas.)
re: Bada Bing
it's not an official dish you'll find anywhere on the web...i made it up :)
shuck & clean several ears of corn, brush with a mixture of olive oil, toasted ground cumin and smoked paprika, and grill or roast until lightly charred in places. slice the kernels off the cobs and add to a bowl. fold in some crumbled or grated anejo or cotija chese and chopped fresh cilantro, and toss with a chili-lime vinaigrette.
re: goodhealthgourmet
Sounds terrific. I'll do a test run. Just bought 8 ears of fresh corn.
re: Bada Bing
that's the base recipe - you can jazz it up a bit if you want to. i love adding sliced grilled scallions and halved grape tomatoes or diced tomatillos. you can even toss in some diced grilled zucchini...
re: goodhealthgourmet
Second the tomatillos! It's excellent with some chipotle en adobo chopped fine and (if you're a fan) cilantro! Ohhh I'm getting hungry.
re: WhatThePho
Great suggestions, whatthepho! I've already meant to add in roasted sweet peppers, and will roast some tomatillos, too. And anything I can get adobo-chipotles into, I go for it!
re: goodhealthgourmet
For chile-lime dressing, I'm supposing the basic approach would be one part lime juice to two parts oil, with seeded chile(s) and maybe cilantro pureed in to taste?
I ask, because I see there are some more elaborate chile-lime dressing recipes involving sweeteners, fish sauce, sesame oil, etc., but I think perhaps simpler will be better if I want to foreground the best produce going just now.
re: Bada Bing
I guess I didn't mix the dressing together, just squeezed lemon juice on the corn and drizzled olive oil. Cracked pepper, a little salt, chopped cilantro, chopped raw tomatillo, chopped up chipotle en adobo with whatever sauce clung to the peppers. I don't really know how much I used or proportions, but I didn't use much oil.
Sorry I'm not being more helpful!! :)
re: Bada Bing
shoot, i meant to elaborate on the dressing...that's where i usually hide the chipotles :) and i should have said "dressing" as opposed to vinaigrette because it's yogurt & sour cream-based.
Creamy Chipotle-Lime Dressing
2 ounces (¼ cup) nonfat Greek yogurt
2 ounces (¼ cup) light sour cream
1 chipotle pepper in adobo sauce, minced
1 tablespoon adobo sauce from chipotle peppers (or more if you prefer extra heat)
2 tablespoons fresh lime juice
1 teaspoon freshly grated lime zest
2 tablespoons red wine vinegar
1 teaspoon agave nectar
½ teaspoon toasted ground cumin
½ teaspoon smoked paprika
½ teaspoon kosher salt
Whisk all ingredients together and refrigerate until ready to use. Makes approximately 1 cup. (Note, if there's a problem with separation/curdling, try whisking in a tablespoon of mayonnaise, or subbing low fat buttermilk for part of the dairy.)
re: goodhealthgourmet
<jaw dropping> holy smokes, GHG, that looks incredible! Drat...just mixed up a Basil Citrus Vinaigrette for my salad for tonight...but must try your chipotle lime dressing very soon!
re: goodhealthgourmet
that does look mouth watering!
re: goodhealthgourmet
Excellent dressing, GHG! I ended up using it (subbing honey for agave nectar, which I don't have) as a dressing for a salad of grilled corn cut from the cob and tossed with roasted red peppers and tomatillos, coarsely grated pecorino romano (a foodsnob idea below), and cilantro. I also tossed in a small amount of ground roasted (but unsalted) peanuts I had left over from a pad thai (that was mainly a texture effect).
Everyone loved it! Thanks for all the help, and also for all the other Hounds' ideas that I'll be getting to work on pronto.
re: Bada Bing
awesome :)
always a pleasure - thanks for reporting back!
re: goodhealthgourmet
GHG - how much in advance can you make the salad? how about the dressing? Should I expect the separation and add the mayo? How much does this yield (people wise)? Thanks!
re: smilingal
you can absolutely make the salad in advance. just be sure to leave it out for a bit before serving to take the chill out of the vegetables (you can even zap it for a few secs to warm it up), and if you want to add tomatoes or tomatillos, do it right before serving.
the dressing can be done a day or two ahead. as for separation, sometimes it happens, sometimes it doesn't. so there's no need to add the mayo unless it does separate on you...or you can use buttermilk in the dressing from the start, and you should be in the clear.
as for servings, well, the dressing recipe makes a little over 6 ounces. i don't like my salads overdressed, so i can usually get anywhere from 10-12 servings out of it. but keep in mind that most people are accustomed to 1.5 - 2 Tbsp dressing, so that would only yield 6 - 8 servings.
oh, and a note about the recipe - i wrote that up when i was still using agave nectar on occasion, which is no longer the case. you're certainly welcome to use it, but i now use honey or coconut nectar/sugar.
re: goodhealthgourmet
Thanks GHG! One more thing - as we finished the last of the mayo dressing that I had made as a spread for the roasted corn on it's cob from this past weekend - my husband remarked that it was too spicy for his palate - If I leave out the chipotle pepper from your dressing entirely will it be lacking some zing? what do you think? I didn't make mine with the chipotle - it was another ingredient that gave the heat - maybe even cayenne - i can't remember.
re: Bada Bing
I substitute pecorino romano cheese when I make elotes. It is amazing.
re: foodsnob14
pecorino is a great substitute - similar to anejo but with more bite :)
A Vinagrette based potato or pasta salad would be a good choice. Or a crudite tray with a non-mayo based dip. 3-Bean salad. Hummus and pita chips. Watermelon and feta salad. Grilled vegetable tray.
fruit salad or fruit skewers or a rice or pasta salad with a pesto dressing or union square cafe nuts (yeah they won't stay warm but still good to snack on) or caprese salad
re: Bada Bing
This is a great one to briong for outdoor parties. Roasted Beet stacks with Goats Cheese and Cranberry Pistaccio pesto.
1/2 cup toasted pistachios
1/2 cup dried cranberries
3 cloves roasted garlic
2 sprigs fresh parsley
1/2 cups olive oil
salt and freshly ground black pepper to taste
Place the pistachios, cranberries, garlic and parsley into a food processor and process until very finely chopped. While the food processor is running, slowly drizzle in 2 tablespoons of the olive oil. Spoon out the pesto into a bowl and stir in remaining olive oil. Season with salt and black pepper to taste. The pesto should be slightly sweet and salty.
Meanwhile, roast beets for an hour or so in a 425 oven, peel, then slice in abou t1" thick rounds.
Top beet slices with a dollop of Goats Cheese, then Pesto.
Amazing flavour combo.
re: RodVito
Thinly slicing vegetables make for great salads and stay crunchy for a long time. Thinly slice radish, celery, fennel (any vegetable that you like to eat raw). Add something sweet (maybe some dried figs) something salty (capers, olives, and thinly sliced Parmesan cheese), something rich (toasted pistachios, pine nuts, walnuts) and toss it in a champagne vinegar or lemon juice vinaigrette.
Southwestern grilled potato salad: grill off parboiled potato slices (cut about an inch thick)...for the dressing, quarter an onion (I like Vidalia), a few tomatillos,seeded poblano chiles and cloves of garlic; put them in a sheet of foil & drizzle with olive oil. Wrap it up and grill until the veggies are tender. Once the vegetables are cooked, put into a food processor and with it running, drizzle in enough olive oil to thin it out. Add the potatoes to a bowl, along with some sliced green onion, oregano, cumin, s & p. Mix in the dressing and some crumbled queso fresco. This is delicious and can be kept at room or outdoor temp without having to be on ice.
re: Cherylptw
I learned on CH that the (commercially prepared) mayo isn't the culprit; it's actually the potato (and other things).
re: c oliver
Haven't been on this thread for awhile; thanks for posting this...you learn something new everyday
re: Bada Bing
+1 for the Super Slaw. you can see one of our discussions about it here:
I think my all-time favorite easy app. is when tomatoes are ripe and beautiful: all colors of cherry tomatoes, grape tomatoes, heirlooms, cut if necessary; lightly crushed, topped with great olive oil, salt and pepper, and lemon juice or red wine vinegar; handful of crushed basil and some minced garlic (I don't use the garlic though.) A big bowl of this with crostini - Summertime!!
a stack of ham on rye w/mustard sandwiches
cold fried chicken
cold sliced meat loaf
bbq brisket in a slow cooker
cooler corn
As a veteran of may pool parties, I'd say finger foods and simple dips seem the most popular:cheeses and crackers, fruit, vegetables, maybe simple non-dairy dips (I once had a great pureed ratatouille at one pool party), all things that don't require refrigeration. At the ones I've been to, the host provided the main dish, which was cooked just before serving.


text:
Sarasota Condo Rental Photos and Description
Seasonal townhome with a large tandem garage. This home features 2 bedrooms and 2.5 bathrooms, fully equipped kitchen and everyday conveniences of home. Enjoy your getaway, while relaxing at the sparkling community pool or sitting out on one of the three lanais. Willowbrook is a gated community, located in the picture-perfect community of Lakewood Ranch. The home is near beaches, parks, shopping, restaurants, golf, and nightlife.
Details for 2 Bedrooms, Sleeps 4, 3 Bathrooms
- Suitability:
- non smoking only


text:
Originally published May 14, 2014 at 6:03 AM | Page modified May 15, 2014 at 12:48 AM
Recipe: Cornmeal Waffles with Banana Bourbon Syrup
Makes about 10 waffles
These are perfectly fine served with maple syrup or honey dripped on top. But for something more opulent, maple syrup simmered with caramelized bananas, pecans and bourbon — like bananas Foster on a waffle — puts them over the top.
7 tablespoons unsalted butter, more for waffle iron
1 large ripe banana, peeled and sliced into ½-inch-thick rounds
2 tablespoons bourbon
½ cup maple syrup
½ cup toasted chopped pecans, optional
1¼ cups all-purpose flour
¾ cup finely ground cornmeal
1 tablespoon sugar
1 teaspoon baking powder
1 teaspoon fine sea salt
½ teaspoon baking soda
1 cup sour cream or Greek yogurt
1 cup whole milk
4 large eggs, separated
1. Melt 5 tablespoons butter either on the stove or in the microwave. Set aside.
2. In a medium skillet over medium-high heat, melt remaining 2 tablespoons butter until foam subsides. Add bananas in a single layer. Cook, without moving, until undersides are golden brown, two to three minutes; flip and brown other side, two to three minutes more. Transfer to a bowl.
3. Add bourbon to pan and let simmer until mostly evaporated, about one minute. Pour in syrup and pecans; simmer until just heated through. Pour syrup on bananas and cover to keep warm (or reheat just before serving).
4. In a large bowl, whisk together flour, cornmeal, sugar, baking powder, salt and baking soda. In a separate bowl, whisk together sour cream or yogurt, milk, melted butter and egg yolks. Fold wet ingredients into dry ingredients.
5. In a mixer fitted with the whisk attachment, whip the egg whites until they hold stiff peaks. Immediately fold into batter.
6. Heat waffle iron. Using a pastry brush or paper towel, lightly coat iron with melted butter. Cook waffles (using about ½ cup batter per waffle) until golden and crisp. Butter the iron in between batches as needed. Serve waffles immediately as they are ready, or keep warm in a 200-degree oven until ready to serve. Serve with banana syrup on top.
— Melissa Clark, The New York Times
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Find out how regular hands-on investments make a difference in helping your children avoid risky and foolish behaviors. read more
Charisma Magazine
Page 31 of 82
The Ultimate Draft Picks: Who's On Your Team?
From a mentor to a wingman to a group of go-to guys, find out why every man needs a strong support team around him to live a God-honoring life. read more
3 Reasons Why You Need to Attend a Marriage Conference
Many men might shy away from marriage conferences, but find out how invaluable they can be in restoring broken relationships. read more
The Same Old Marriage Fights and How to Change
Most times, arguments between husbands and wives are the result of the same old issues. Find out what you can do to overcome them. read more
Are You an Authentic Man?
The foundation of manhood is being redefined. What can we, as believing men of God, do to reverse the trend? read more
Terror Alert: How to Be Ready for Anything
A godly man needs to be prepared for attacks from the enemy. Find out how to lean on God's Word and defend yourself from these assaults. read more
12 Things That Can Cause Marriage Failure
Satan tries to ruin your marriage with many stumbling blocks. Read and find out which ones are most pertinent in your relationship with your spouse. read more
How to Stay Above the Perilous Line Between Marriage and Divorce
Statistics says the odds are against couples enjoying lengthy marriages. It's a victory that can be won, however, and here's how. read more
Exploring a Husband's Role as a Prophet, Priest and King
In theology, Christ occupies the classic threefold office of prophet, priest and king. Find out how that relates to you as a husband. read more
A Guide to Writing a Love Letter to Your Wife
Words on paper can last forever. When is the last time you penned a love letter to your wife? read more
7 Stumbling Blocks to Sexual Purity
Women struggle with sexual temptation as much as men although it's more subtle. Here are 7 ways ...
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9 Things Wives Should Never Say to Their Husbands
This time, it's the husbands' turn. What other phrases have you discovered that cause more ...
The Danger of Christian Celebrity
The world doesn't need more Christian celebrities. Neither does the church
Praying Down Powers and Principalities
Many people go to unhealthy extremes in their approach to spiritual warfare. Instead of diving down ...
What Would Jesus Say to Kim Kardashian?
Jesus offers His salvation to everybody—even if you are a reality TV star who poses nude.
10 Foods That Increase Your Risk of Cancer
Plain and simple, here are some foods (and drinks) that you should stay away from.
Your Real Worst Enemy Is Closer Than You Think
One simple strategy will cause this adversary of your soul to immediately bow, but you have to see ...
Warring With Wisdom and Revelation
God is calling us to a higher level in spiritual warfare. Here's how you can up your game for ...
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Not all signs related to the Second Coming are negative. Here are seven encouraging and exciting ...
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6 Keys to Keep the Fire of God Burning in Your Life
Every day we're faced with challenges that can quench the flame of faith. Here's how to fan ...
7 Characteristics of Authentic Prophetic Ministry
Too much of the church is sinking in the quagmire of apostasy. Here are key scriptural elements ...
3 Things to Do When You're Drowning Spiritually
Stop flailing your limbs and cursing your situation. Take these simple steps to grow beyond the ...
10 Deadly Mindsets in the Church
Here are some negative paradigms that impact a church. Find out if you fall into them.
5 Financial Red Flags That Can Sink Your Family
Are you barely keeping your head above water financially? Is it because of one, some or all of ...
4 Kingdom Laws for Understanding Angels
It is essential for us to know how to receive and activate God's supernatural (and often ...
4 Overlooked Ways the Holy Spirit Is Active
The Holy Spirit moves in the most unexpected ways. Here are four activities of the Spirit we should ...
2 Key Deceptions Behind Your Spiritual Battles
The enemy is the master of lies, and he seeks to weaken our defenses with these key deceptions. But ...
Is This When the Rapture Is Really Coming?
Though no man knows the day or the hour of Christ's return, John Shorey says he's decoded a ...
A Powerful Prophetic Promise for the Weary
The enemy of your soul wants to make you think perception is reality. Thank God He's given us ...
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The enemy hates you and comes to kill, steal and destroy, but he's got some very real ...
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Skysports.com understands Brentford are closing in on the signing of Leicester midfielder Nicky Adams.
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Brentford boss Andy Scott has held a long-term interest in Adams and is keen to bring him to Griffin Park.
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A number of clubs were thought to be keen on signing Adams, but Brentford appear to have stolen a march on their rivals for the former Wales Under 21 international.
Brentford are in talks with Leicester about a fee for Adams and are hopeful of agreeing a deal for the midfielder.


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-DaNuTz- Blog
Steam Holiday Sale Report
by -DaNuTz- on Comments
Top 10 Spookiest Villain
by -DaNuTz- on Comments
My JRPG
by -DaNuTz- on Comments
The story is set in a fantasy land located on separate margins of the Earth, ruled by 2 kings: Shurubel and Pufuletz. After receiving several death threats from his enemies, Shurubel fears for his life and addresses a letter to Pufuletz, asking him to send either of his three sons, promising to grant the one who would help him , his only daughter. Meanwhile, Shurubel's castle is attacked and he loses over half of his army. He's been injured badly but he won this battle. After reading the letter and hearing what happened the last day, Pufuletz sends his sons immediately to aid him in battle.
This is where the adventure starts. You play as one of the three sons trying to find more about Shurubel, a backstory of what has he done to deserve this, who are his enemies, dark secrets about his daughter, the relationship between the two kings and much more. There are many riddles to solve, evil creatures to destroy, great boss battles and of course huge rewards. Depending on who do you chose to play as and the decisions you make throughout the game, there are different endings and you may want to replay it to find answers for all your questions.Characters: Goanga: - The eldest son of King Pufuletz. Basic tank and melee class. ---------------------------------------------- HP: 150 MP: 60 Agility: 5 Strength: 13 Inteligence: 4 Defence: 10 Skills: Hateful Strike, Taunt, Divine Shield, Curse Weapons: Sword, Hammer Shoimul: The middle son of King Pufuletz. Basic caster class. ---------------------------------------------- HP: 50 MP: 70 Agility: 15 Strength: 15 Inteligence: 15 Defence: 10 Skills: Stealth, Dazing Traps, Steal, Poison Weapons: Dagger, Short sword Furnicaru: - The youngest son of King Pufuletz. Basic ranged class. ---------------------------------------------- HP: 125 MP: 250 Agility: 25 Strength: 7 Inteligence: 12 Defence: 7 Skills: Black Arrow, Starfall, Heal, Lightning Strike Weapons: Bow Boss: Ursuletz ---------------------------------------------- Ursuletz is a powerfull ancient evil, six legged creature. All those who faced him before, perished. Having a wide range of skills allows him to win his battles without much effort. He's the one responsible for the attack at King Shurubel's castle and you will have to kill him to complete the main quest and restore the peace in the land. Why I think this game is worth playing - Dynamic story - Multiple endings depending on your actions - Great boss battles
TGS Puzzler Activity
by -DaNuTz- on Comments
bigger version
Finally over after 15 years ...
by -DaNuTz- on Comments
Today I got my Bachelor's Degree in Informatics.
Am I proud of myself ? Yes.
Was it worth it ? Not really.
Do I think it will help me get a better job ? No, in this country it is just another useless paper.
But ... I'm glad it's over. Starting a new phase in my life.
Look what i got :)
by -DaNuTz- on Comments
Even though no one is reading my blog anymore, I r too happy not to share this special moment with all of my puffy friends from Gamespot :P ... lmao
Better late than never: Merry Christmas and Happy New Year :D
Also, you can find me on Facebook (lol, don't ask) ... send me a pm with your profile :P
Ornament Hunt
by -DaNuTz- on Comments
Clue 01: Van Nguyen
Clue 02: Jody Robinson
Clue 03: Guy Cocker
Clue 04: Matthew Gravish
Clue 05: Chris Watters
Clue 06: Kevin VanOrd
Clue 07: Aaron Sampson
Clue 08: Alex Sassoon Coby
Clue 09: Werner Goff
Clue 10: Jan Heir
Clue 11: Randolph Ramsay
Clue 12: Andrew Park
Clue 13: Mark Walton
Clue 14: Justin Covert
Clue 15: Sophia Tong
Clue 16: Kurtis Seid
Clue 17: Giancarlo Varanini
Clue 18: Justin Porter
Clue 19: Ryan MacDonald
Clue 20: Tyler Winegarner
Clue 21: Maxwell McGee
Clue 22: James Kozanecki
Clue 23: Frank Adams
Clue 24: Sarju Shah
Clue 25: Shaun McInnis
Clue 26: Ricardo Torres
Clue 27: Tom Magrino
Clue 28: Dan Chiappini
Clue 29: Homer Rabara
Clue 30: Takeshi Hiraoka
Clue 31: Tor Thorsen
Clue 32: Jim Maybury
Clue 33: Carolyn Petit
Clue 34: Tom McShea
Clue 35: Dan Mihoerck
Clue 36: Jane Douglas
Clue 37: Brendan Sinclair
Clue 38: Laura Parker
still alive ?
by -DaNuTz- on Comments
If you are, I wish you a Merry Christmas and a Happy New Year
May the light of Eärendil be with you my friend :P


text:
The total annual cost of EU membership to the UK could rise to 20% of GDP if the EU continues with its current economic policies, a tendency likely to be reinforced by the proposed constitution. This is according to a new study of UK membership of the EU by Professor Patrick Minford. The book, Should Britain Leave the EU?, is published on 2 June 2005.
In the book Professor Minford explains that this potential cost is so large because of:
Excessive regulation in labour and product markets; and
The UKs possible share of the enormous EU pension liabilities.
The cost of the EU to Britain is equivalent to the UK economy rem


text:
Buffalo Deshawn Jean
SALE $53.97 was $113.00 Item #19380BM11786
Sorry, this product is currently not available on buckle.com.
- Slim fit straight leg zip fly jean
- Low rise, 18 1/2" bottom opening
- Tacking, hand sanding and cuts with fill yarn details
- Embroidered back pockets
- 100% Cotton.
- Machine wash cold with like colors. Do not bleach. Tumble dry low. Use warm iron.
- This quality denim has been hand finished for a unique, individual look. It will wear like your old favorite jeans, with each hole and tear continuing to destruct over time. We hope you love the vintage appearance and comfort of wearing jeans that have the look and feel of years of wear. Thanks for making the Buckle your denim destination.
- Made in China.
Have a Question?
Email Guest Services.
We changed our page. Tell us what you think.
D Fits have slightly more room in the hips and thigh than the "S" Fits.


text:
Jasmine Ivey and Alyssa Cantu are still collecting hardware in their already-decorated senior campaigns.
Ripon Christian's girls soccer team can steal a piece of the Southern League championship this Wednesday when it welcomes Mariposa.
Logan Jackson continues to make a splash in a sport where Buffalo don't often roam – diving.
A heavy thunderstorm brought rain, wind and even some hail on Friday, washing out the local sports calendar.
Joshua Patton had a goal in mind when he first stepped foot on the Sierra High campus as a freshman.
RIPON – March 22, 2005.
Jack Thomson believes he's found another arm to bolster Sierra's run at a Valley Oak League championship.
On the diamond, Dakota Conners hasn't made many errors in judgment or position.
The wall in Frank Fontana's classroom bears the images and years of championships past.
Kimball got redemption against Sierra on Wednesday during a rematch of last year's Sac-Joaquin Section Division IV championship.
MODESTO – One day after his pitching staff was burned by Beyer in a double-digit loss, Jon Manrique did what most do in emergency situations.
WOODLAND – In years past, John De Visser has played his cards close to his chest with Woodland Christian, refusing to throw his top pitchers against a perennial playoff team.
Oakdale kept its foot on the gas against the rest of the Valley Oak League after shutting out Lathrop 10-0 in a shortened five-inning contest.
The East Union girls varsity track squad came up shy of sweeping Wednesday's tri-meet against both Sonora and Sierra.
Manteca's girls tennis team ended the first round of Valley Oak League play with a pivotal 5-4 win at Oakdale despite missing two regular doubles players Tuesday.
Lathrop threatened to force a fifth set but came up short against visiting East Union, which prevailed 25-15, 25-22, 13-25, 25-21 for its first Valley Oak League victory of the season.
McKenna Doyle posted her best score of the season Tuesday at Manteca Park Golf Course and was low medalist in Sierra's 258-287 victory over Oakdale.
Ripon Christian got back on track Tuesday with a 4-1 win at Waterford.


text:
Originally published January 7, 2014 at 6:34 AM | Page modified January 8, 2014 at 2:47 AM
2 icebreakers trapped in Antarctica break free
A Russian research ship at the center of an Antarctic rescue drama has broken free from heavy pack ice two weeks after it became trapped, officials confirmed on Wednesday, hours after a Chinese icebreaker that became trapped while trying to help the Akademik Shokalskiy also freed itself and was heading for open waters.
A Russian research ship at the center of an Antarctic rescue drama has broken free from heavy pack ice two weeks after it became trapped, officials confirmed on Wednesday, hours after a Chinese icebreaker that became trapped while trying to help the Akademik Shokalskiy also freed itself and was heading for open waters.
The Akademik Shokalskiy had been trapped in ice-clogged Commonwealth Bay since Christmas Eve, while the Chinese ship that came to its rescue, Xue Long, or Snow Dragon in Chinese, reported last week it too was stuck.
But the Snow Dragon was able to use its helicopter to retrieve 52 scientists, journalists and tourists from the Russian ship. They are now on their way home aboard an Australian icebreaker, Aurora Australis.
The Chinese official Xinhua News Agency reported from the Snow Dragon, with 101 crew aboard, on Tuesday that it successfully escaped after making a 100-degree turn and pushing away the ice, and opening up a channel of water.
Russia's state news agency ITAR-Tass reported that the Akademik Shokalskiy, with its 22 crew who had stayed on board, was making its way out of the dense ice on its own.
The Australian Maritime Safety Authority's Rescue Coordination Centre, which is responsible for rescues in the region, said it was informed early Wednesday that both ships had managed to break free and were making slow progress through lighter ice conditions toward open water.
The center's spokesman Sam Cardwell told the Australian Broadcasting Corp. radio that a shift in the winds "...took the pressure off the ice and allowed them to break free."
A U.S. Coast Guard heavy icebreaker, Polar Star, cut short an Australian stopover on Sunday to head to the rescue of the two icebreakers by clearing a navigational path through Commonwealth Bay. The journey from Sydney was expected to take the 122-meter (399-foot) cutter a week.
The Coast Guard said Wednesday that the Polar Star had now changed its course for Antarctica's Ross Sea to fulfill its original mission.
The Polar Star left its Seattle homeport last month on a mission to break a channel through the sea ice of McMurdo Sound to allow the resupply and refueling of the U.S. Antarctic Program's McMurdo and Amundsen-Scott South Pole stations.
The Australian icebreaker was headed toward Australia's Casey Station, which it will resupply before returning to the Australian state of Tasmania with the 52 passengers from the Akademik Shokalskiy.
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- We're no better than Ferguson; maybe worse | Danny Westneat
- Grand jury faced a tangle of eyewitness accounts


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More indications there is life in outer space
Three new research articles show that the conditions for life as we know it here on Earth exist in the universe.
European Space Agency sets date for comet landing
European Space Agency sets Nov. 12 date to attempt first comet landing
Recovery of bodies suspended at Japanese volcano
Toxic gas worries cause rescuers to suspend recovery of bodies from deadly Japanese volcano
Why bats are being spied on in a local meadow
Shannon Pederson, a phD student and teaching assistant at the University of Maryland, has installed microphones in a meadow at the Audubon Naturalist Society's Woodend Sanctuary.
University launches beer-making program
Central Michigan University launches 'fermentation science' program to fuel microbrew industry
GE to give Penn State $10M for gas drilling center
Penn State: GE to give $10M for gas drilling research center, teaching programs
Indonesia enlists wasps in war on crop killer
Tiny wasps tasked with saving Indonesia's cassava crop from devastating pest
FACT CHECK: Obama's UN speech spins statistics
FACT CHECK: Obama skirts some inconvenient truths in UN climate-change speech
Glen Canyon Dam marks 50 years as power source
US officials hail 50th anniversary of Glen Canyon Dam as power source for drought-prone area
Mars missions: Successes and failures
World's successes and failures in Mars missions
Changes ordered at Los Alamos over nuke waste leak
Los Alamos cleanup officials reassigned, changes ordered over nuke waste leak
Businesses and investors pressing for green policy
Ahead of UN summit on climate change, businesses are pressing for market-based solutions
Official: Wreck off Haiti likely not Columbus ship
Haiti official says evidence so far suggests wreck off north coast isn't Columbus ship
Expanded US ocean preserve to be world's largest
Ocean preserve expanded by Obama will be world's largest, 3 times the size of California
Mexico sees sign of hope for Monarch butterflies
Mexico sees tentative sign of hope as Monarch butterflies show up early
Renewable energy plan hinges on huge Utah caverns
Vast, man-made caverns in Utah hold promise for balancing out renewable energy supply, demand
Spokane sewage could be tested for marijuana level
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Mars mission opens India for space business
India's Mars mission is boon for its space business and inspiration for homegrown scientists
US issues new rules for university germ research
US tells universities, scientists to do more to flag germ research with biosecurity concerns
Editorial Roundup: Excerpts from recent editorials
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Fri, Jun 03, 2005
Residents of the West Side in Manchester, NH, have an answer to
one of their most pressing questions: Why was a military aircraft
roaring low over their homes Tuesday and is there anything to be
worried about?
The answers: That was a US Navy F/A-18 Hornet cruising low over
the 'hood. The aircraft, dispatched from Maine's Brunswick Naval
Air Station. The aircraft, based at NAS Oceana in Virginia, was on
a testing and evaluation mission.
The Hornet was, in short, acting as target in the testing of a
new target acquisition radar recently installed on an Aegis-class
cruiser steaming just offshore.
Authorities received several dozen complaints about the
low-flying aircraft since Tuesday evening. The pilot performed
several abrupt-looking maneuvers. When the Manchester Union-Leader
asked NAS Brunswick spokesman John James, he responded, "They do
Manchester Airport's assistant director, Brian O'Neill, told the
Union-Leader no one in the tower was talking to the Hornet driver.
But, he said, that's not unusual and "We had no issues [with
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Home » News » Public Safety
Laconia classmates mourn friend, root for recovery of another girl injured in crash
The condition of the injured girl, Alyssa Miner, has been upgraded to fair at Dartmouth-Hitchcock Medical Center in Lebanon, where she was flown with critical injuries after both girls were hit by a car.
Another student, Lilyanna Johnson, 14, died at the hospital Friday night.
The girls were students walking home from Laconia Middle School when the accident happened about 2:30 p.m. Friday.
On Saturday, grief counselors and other members of the community were on hand to speak with students affected by the tragedy at the school during the morning and afternoon.
The Saturday session allowed counselors to be made available to students, who will be on vacation next week.
Students have also been invited to share their thoughts, remembrances and condolences through the school website.
"The LMS community is mourning the loss of Lilyanna Johnson and the injury of Alyssa Miner," said a notice. "Share your memories, thoughts and condolences."
Laconia Police Capt. Matt Canfield said the girls were hit when one car stopped at a crosswalk to allow the girls to cross the street and another car "suddenly veered" from behind the stopped car and hit one girl, a guardrail and the second girl.
One of the girls was thrown into the air and landed on the car's hood and windshield before falling to the pavement, Canfield said.
Police identified the driver of the car as Amy Lafond, 51, of 10 River St. Laconia,
Her car came to rest against the guardrail on the other side of the street, police said.
As of Saturday, no charges had been filed against Lafond in connection to the accident, Sgt. Dennis Ashley said.
Police are seeking information from anyone who may have seen the accident. Information can phoned to Laconia police at 524-5252, by calling the Laconia Crimeline at 527-1717 or at laconiapd.org
Staff Writer Bill Smith contributed to this report.
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The Genetics Website Committee Will be Hosting a Q&A and Eric Monson will Present his Research on Wednesday, 11/12/14
Eric's Abstract
Assessment of Whole Exome Sequence Data in Attempted Suicide
In this study, we present the first large-scale sequencing project designed to assess the role of functional genetic variation within the human exome in the risk for suicidal behavior. Our analysis takes advantage of recently-developed variant collapsing methods to determine whether suicide attempters have elevated rates of functional mutational burden as compared to non-attempters. To do this, we generated whole exome sequencing data for 387 bipolar subjects with a history of a moderate or serious suicide attempt and 631 bipolar subjects with no history of suicide attempt. Additional sequencing targets for core regulatory regions of approximately 1500 genes predicted to be involved with synaptic function were also included in the data. Functional variant sets were assessed in groups defined by gene-loci and pathways using mutational burden and sequence kernel association tests. No signals survived correction for multiple testing. Our suggestive findings implicate glutamatergic signaling, as did our previous genome wide association study. This study demonstrates a first look at the potential power behind whole exome sequencing in the investigation of functional coding and regulatory variation contributing to the complex phenotype of suicidal behavior and the promise such techniques might afford as large scale next generation sequencing efforts continue to expand.
Sophia Gaynor and Hannah Seberg Will Present Their Research Wednesday, 10/8/2014
Sophia's Abstract
S. Gaynor1, E. Monson1, M. Breen1, K. Novak1, J.B. Potash1, V.L. Willour1
1 University of Iowa, Department of Psychiatry
Suicidal behavior is a complex phenotype with an estimated heritability of 30-50%. While this heritability is partly dependent on the presence of psychiatric disorders, other evidence implicates an independent heritable factor. In order to assess the genetic basis of this independent factor, we are conducting a next-generation targeted sequencing project on 38 candidate genes and two candidate regions in 500 bipolar (BP) subjects that have attempted suicide and 500 BP subjects that have not attempted suicide. The candidate genes and regions were chosen based on hypotheses generated by our lab and evidence from the suicide literature. The target regions for sequencing include all exons of all alternative transcripts, intron-exon boundaries, alternative promoter regions, and any putative regulatory elements identified by ENCODE, including 10kb upstream and downstream of each gene. We currently have completed the sequencing for all of our samples and have data analyzed for 505 of these samples, including 254 BP attempters and 251 BP non-attempters. For these first 505 samples, we found 14,159 unique variant sites following quality control filtering. We performed both individual variant tests and gene burden tests on these variant sites. Our top findings from the individual variant testing include an intergenic region of 2p25 (p=1.20×10-4) and an intronic region of LRRTM4 (p=7.16×10-4). For gene burden testing, our top results based on p-value are DLG3 (p=1.07×10-2) and TMEM132A (p=1.3×10-2). Our top results based on odds ratio are NLGN4X (OR=0.191) and GRIN2B (OR=5.02). We are currently in the process of analyzing the remaining samples, and the addition of these samples will provide more power to identify significant variant or gene associations. The identification of variants associated with suicidal behavior in these candidate genes and regions will help elucidate the biological basis of this complex phenotype.
Hannah's Abstract
TFAP2A and MITF work in parallel to activate melanocyte differentiation genes
Hannah Seberg1, Eric Van Otterloo2, Gregory Bonde2, Robert Cornell1,2
1Interdisciplinary Program in Genetics, 2Department of Anatomy and Cell Biology
Transcription factor activator protein 2 alpha (TFAP2A) is widely expressed in the neural crest and multiple neural crest-derived cell types, including melanocytes. Mutations in tfap2a cause pigmentation phenotypes in humans, mice, and zebrafish. However, it is unclear how TFAP2A activity relates to that of lineage-specific Micropthalmia-associated transcription factor (MITF), which directly regulates melanocyte differentiation effectors such as melanin synthesis genes. This issue is complicated by the redundant expression of Tfap2 paralogs. In zebrafish melanocytes, tfap2e is highly expressed along with lower levels of tfap2a and tfap2c. To study the role of multiple paralogs in melanocyte development, we created a tfap2e mutant using zinc finger nucleases. Whereas the number of melanocytes in tfap2a mutants is reduced by about 66%, tfap2e mutants have no discernable phenotype. However, tfap2a/e double mutants display about 50% reduction of melanocytes, suggesting partially redundant functions for tfap2a and tfap2e. We next assessed the genetic interaction between tfap2a and mitfa. Single heterozygous embryos are phenotypically normal, while tfap2a;mitfa double heterozygotes have fewer melanocytes. These data indicate that TFAP2A and MITF interact genetically, but the mechanism of this interaction is unknown. To test the model that TFAP2A and MITF co-activate melanocyte differentiation genes, we identified genes that are likely to be direct targets of TFAP2A. First, we generated a profile of genes that are significantly downregulated in trunks of tfap2a null zebrafish embryos. We then conducted anti-TFAP2A ChIP-seq in human primary melanocytes to create a profile of TFAP2A-bound loci. Genes at the intersection of these profiles include several melanin synthesis genes, such as DCT, PMEL, and OCA2. Many of these genes are also known to be direct targets of MITF. These results provide evidence that TFAP2A and MITF work in parallel to promote melanocyte differentiation, and show that the widely-expressed transcription factor TFAP2A can directly regulate expression of lineage-specific targets.
Michael Molumby and Salleh Ehaideb Will Present Their Research Wednesday, 9/10/14
Michael's Abstract
Branching out by sticking together: gamma-protocadherins regulate dendrite arborization
The a-, b-, and g-Protocadherins (g-Pcdhs) are cadherin superfamily adhesion molecules encoded by clustered gene families. The 22 g-Pcdhs are combinatorially expressed in the brain, and play critical roles in synaptogenesis, dendrite arborization, and the survival of subsets of neurons. We have shown that the g-Pcdhs promiscuously form cis-tetramers that interact strictly homophilically in trans (Schreiner and Weiner, PNAS, 2010). The g-Pcdh cluster could thus generate 104-105distinct adhesive interfaces, providing CNS cells with molecular identities. We recently showed that the γ-Pcdhs promote cortical dendrite arborization by inhibiting a FAK/PKC signaling pathway (Garrett, et al., Neuron, 2012).
Here we provide further evidence for cortical dendrite arborization mediated by γ-Pcdhs homophilic matching. We demonstrate that Emx-Cre driven overexpression of a single γ-Pcdh isoform (A1 or C3) in the cortex increases dendrite arborization compared to control mice. We hypothesize that this increase is a result of increased matching of γ-Pcdhs tetramers in trans-interactions from the over expression of a single γ-Pcdhs isoform (γ-Pcdh-A1/C3) in the cortex. To further support our hypothesis, we are pursuing experiments to disrupt trans-interactions of g-Pcdhs in vitro and in vivo to examine the effect on dendrite arborization.
Salleh's Abstract
Elucidating the mechanism of epilepsy in flies
Prickle spiny-legs (Pksple) is one of two adult isoforms encoded by the prickle gene, and plays a role in the non-canonical WNT signaling/planar cell polarity (PCP) pathway in flies. We previously reported that pksple mutants are seizure-prone, and that mutations in prickle orthologues are associated with myoclonic (muscle jerk) seizures in both flies and humans. Using a seizure stimulation paradigm, we find that the pksple heterozygous flies have a lowered seizure threshold compared to control flies, with increases in spiking activity after electric shock, similar to what is observed for other seizure-prone flies. Such seizure activity can be ameliorated by treatment with valproic acid, a human anti-epileptic drug which has been shown to be effective in treating human patients with PRICKLE mutations. Since these patients also suffer from ataxia, or uncontrolled gait, we developed an assay to assess whether our pksple flies had similar phenotypes. Notably, both pksple homozygotes and heterozygotes exhibited a statistically significant loss of coordinated gate compared to controls, with loss of both functional pksple copies resulting in a more severe ataxia than loss of just one copy. These data further underscore the striking parallels between the prickle-associated myoclonic epilepsy syndromes observed in flies and humans.
Presentation Schedule: Fall 2014
|Michael Molumby
|Salleh Ehaideb
|Hannah Seberg
|Sophia Gaynor
|Jessica Ponce
|Eric Monson
|Patrick Lansdon
|Lisa Harney
Allison Cox and Hung-Lin Chen Will Present their Research Thursday, 8/7/14
Allison's Abstract
Whole Exome Analysis of Individuals and Families with Chronic Recurrent Multifocal Osteomyelitis (CRMO)
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, autoinflammatory bone disease presenting in infancy and childhood. While CRMO is characterized by painful bone lesions, it is often comorbid with psoriasis or Crohn disease and many patients have close relatives with either of the more common disorders. Some syndromic cases of CRMO are caused by truncation mutations in the interleukin-1 receptor agonist (IL-1RA) gene and these children respond very well to treatment with recombinant IL-1RA. However, most cases are non-syndromic with an unknown genetic cause, although many patients respond to TNF-α blocking agents, implicating the pathway in the disease. Using whole exome sequencing paired with genetic analyses based on inheritance patterns in several affected families, I hope to determine a component of CRMO's underlying genetics. Preliminary results implicate a shared pathway in the pathogenesis of the disease. I am currently sequencing a candidate gene in a large cohort of CRMO samples from our laboratory.
Hung-Lin's Abstract
Effect of diet on genetically inherited seizure-like behavior in Drosophila
Hung-Lin Chen,1 Patrick Lansdon,1 Junko Kasuya,2 Toshihiro Kitamoto1,2
1Interdisciplinary Genetics Ph.D. Program and 2Department of Anesthesia
Nutritional therapies have the great potential to prevent or treat various neurological disorders, such as epilepsy, in an effective, natural, and economical manner. However, their exact therapeutic values have not been rigorously evaluated in most cases and the molecular mechanisms responsible for their beneficial effects remain elusive. The goal of this study is to unravel the fundamental molecular underpinnings of nutritional therapies for genetically inherited neurological dysfunctions using the fruit fly Drosophila melanogaster as a model organism. Shudderer (Shu) is a classical Drosophila mutant that is characterized by strong spontaneous jerking and twitching. Our molecular analysis revealed that Shu carries a gain-of-function mutation in the voltage-gated sodium channel gene, paralytic. Here we report that feeding Shu mutants a modified diet results in drastic improvement of their seizure-like phenotypes. Shu needs to be fed the "therapeutic" diet during the larval stage in order to receive a maximum benefit from the food, suggesting that the diet has a therapeutic effect on Shu by affecting development of the nervous system. These findings are significant because they provide an unprecedented opportunity to employ versatile experimental tools available for Drosophila and investigate the mechanisms underlying the diet-dependent improvement of inherited behavioral abnormalities under strictly controlled genetic and environmental conditions.
University of Iowa Alumni Igor and Patricia Schneider Will Meet with Genetics Students 7/24/14
Danielle Herrig and Autumn Marsden will Present their Research Thursday, 7/10/14
Danielle's Abstract
Speciation typically occurs when a single species splits into two populations in which gene flow is severely reduced. Over time, the two populations accumulate genetic differences that eventually produce two independent species. While hybridization between two species, and thus the potential for gene exchange, has traditionally been viewed as a reproductive mistake, recent studies suggest that it is not as rare as once believed. Previous studies suggest that although regions of the mitochondrial and nuclear genomes can be exchanged independently or together, the X chromosome often plays a large role in speciation and gene exchange is typically barred on the X. One way in which the X chromosome may play a large role in speciation is though X-linked trans-regulatory elements (TREs) effecting the expression of autosomal genes through interactions with autosomal cis-regulatory elements (CREs). Indeed, whole-genome analyses of gene expression in our lab indicate that X-linked genes are more differentially expressed between species while autosomal genes are preferentially misexpressed in hybrid males. Because there is only one copy of the X chromosome producing X-linked TREs in hybrid males, we hypothesize that the hemizygosity of the X chromosome leads to greater levels of autosomal misexpression in the heterogametic sex. To investigate the effects of the uni-parental origin of the X chromosome on autosomal misexpression, we will analyze whole-genome expression in attached-X stocks of Drosophila yakuba, D. santomea, and their hybrids wherein the X chromosomes are inherited in a uni-parental manner in females. It is my expectation that if the hemizygosity of the X chromosome contributes to autosomal misexpression in males, attached-X F1 hybrid females will mimic results from F1 hybrid males.
Autumn's Abstract
Calcium-dependent Naked-Dishevelled Interaction Modulates Wnt Signalling Outputs
AN Marsden1,2, SW Derry1, TA Westfall1, DC Slusarski1
1Department of Biology, University of Iowa, Iowa City, IA 52242, 2Interdisciplinary Graduate Program in Genetics
The Wnt signaling network plays critical roles in development and is implicated in human disease. Wnts comprise a complex signaling network that, upon ligand binding, activates the phosphoprotein Dishevelled (Dvl), leading to distinct outputs including polarized cell movement (known as planar cell polarity, Wnt/PCP) and stabilization of the transcription factor β-catenin (Wnt/β-catenin). The mechanisms that determine a specific output is not completely understood, especially since they share receptors and cellular effectors. My project focuses on two such shared components that also bind each other, Dvl and Naked (Nkd). Previously we demonstrated that Nkd is required for zebrafish dorsal forerunner cell (DFC) migration, Kupffer's vesicle formation and proper organ laterality. Moreover, we identified calcium fluxes in the DFCs and determined that the EF-hand motif in Nkd weakly binds calcium. Using a combination of biochemical and functional assays, we show calcium-induced conformational changes in the Nkd-Dvl complex and identify a requirement for the Nkd EF-hand in cell polarity but not in β-catenin transcriptional outputs. We predict that Nkd and Dvl form a cooperative calcium binding pocket, which allows for conformational changes or subcellular localization to direct Wnt/PCP output. We identified a region in Dvl that may coordinate ion binding. We have mutated this novel Dvl calcium binding site, and performed biochemical, genetic, and functional studies. To determine the impact upon Wnt signaling output, I utilize gene knockdown and rescue in the zebrafish DFCs, in a tissue that hosts converging Wnt signals. I also determined the subcellular localization of Nkd and Dvl components within the cells known to have calcium fluxes and cells that are quiescent. Our data suggests that calcium-induced secondary structure changes in the Nkd-Dvl complex serve to interpret the physiology of a cell receiving multiple cues and provides mechanistic insight into Wnt signal integration in vivo.
Emily Beck and Fengxiao Bu Present Their Research Thursday, 6/26/14
Abstract for Emily Beck
Cyto-nuclear co-intogression in the sister species Drosophila yakuba and D. santomea
Introgression, also called introgressive hybridization, is the effective exchange of genetic information between species through natural hybridization, and can occur when reproductive isolation is incomplete. Previous genetic analysis of the hybrid zone formed by Drosophila yakuba and its sister species D. santomea showed that the mitochondrial genome of the former species had introgressed into the latter and completely replaced its native form. Since mitochondrial proteins work intimately with nuclear-encoded proteins in the oxidative phosphorylation (Oxphos) pathway, we hypothesized that some nuclear genes in Oxphos co-introgressed along with the mitochondrial genome allowing for preservation of function. We analyzed nucleotide variation in the 12 nuclear genes that form cytochrome c oxidase (COX), an Oxphos enzyme complex composed of both nuclear- and mitochondrial-encoded proteins, in 33 Drosophila lines. Using maximum likelihood methods, we detected significant introgression from D. yakuba to D. santomea in only the three nuclear genes composing subunit V of this complex. The detection of introgression in the three proteins that work together in same subunit, interact with one another, and directly with the mitochondrial-encoded core strongly supports coordinated cyto-nuclear co-introgression to allow for optimal COX activity. We aim to investigate the nuclear genes of all the other subunits of Oxphos (88 genes total) for evidence of co-introgression.
Abstract for Fengxiao Bu
CFH-mutation related atypical hemolytic uremic syndrome may be modulated by Coagulation factor X
F. Bu1,2, N. Borsa2, W. Tollefson3, M. Schnieders3, H. Azaiez2, K. Wang4, C. Thomas2,5, C. Nester2,5, R. Smith1,2,5
1) Interdepartmental PhD Program in Genetics, University of Iowa, Iowa City, IA; 2) Molecular Otolaryngology and Renal Research Laboratories, University of Iowa, Iowa City, IA; 3) Department of Biochemistry, University of Iowa, Iowa City, IA, USA; 4) Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA; 5) Rare Renal Disease Clinic, Departments of Pediatrics and Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA,
Background: Atypical hemolytic uremic syndrome (aHUS) is a complement-related rare renal disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. Mutations in CFH account for approximately 22% of aHUS cases. In familial cases, CFH-mutation penetrance ranges from 12.5% to 100% suggesting the involvement of other genetic factors/modifiers in the etiology of this disorder.
Methods: Five families carrying the same disease mutation – c.3644G>A, p.Arg1215Gln – in CFH were included in this study. Using targeted genomic enrichment and massively parallel sequencing, all coding exons of genes in complement and coagulation cascades were screened for coding variants. Data were analyzed using a customized local Galaxy pipeline. After filtering for quality and frequency, novel and rare variants were annotated based on computational algorithms and reported studies. For selected variants the predicted functional impact was confirmed in vitro.
Results: A known factor X deficiency variant (F10 c.424G>A, p.Glu142Lys) was identified in a three-generation pedigree. No carriers of both the F10 p.Glu142Lys variant and the CFH p.Arg1215Gln variant developed aHUS, although two persons carrying only the CFH p.Arg1215Gln variant developed disease in early childhood. Protein modeling shows that wild-type Glu142 hydrogen bonds with Cys129, while mutated Lys142 hydrogen bonds with Ser146, a shift that destabilizes an important intra-light-chain interaction between a two-stranded beta-sheet and a small alpha-helical secondary structure element. Consistent with this prediction, recombinant mutant factor X secretion was altered in HEK293 cells and its activity was reduced by 30%.
Conclusion: We have identified a variant in F10, p.Glu142Lys, that may modify CFH-related aHUS perhaps protecting CFH-mutation carriers from developing the phenotype.This finding may explain some instances of incomplete penetrance and offer new therapeutic targets to treat this life-threating disease.
Presentation Schedule: Summer 2014
|Jennifer Teitle: The Versatile PhD
|Emily Beck
|Fengxiao Bu
|Danielle Herrig
|Autumn Marsden
|Igor and Patricia (Genetics Alumni)
|Hung-Lin Chen
|Allison Cox
Melissa Marchal and Changya Chen Will Present Their Research on May 22, 2014
Melissa's Abstract:
The Role of Maternal Wnts and Frizzleds in Dorso-Ventral Axis Specification
Elucidating the molecular mechanisms that transform a symmetric egg into a more complex embryonic body has interested developmental biologists for some time. The asymmetric distribution of determinants within the oocyte is critical to normal developmental processes such as dorsal axis determination and cell migration. In Xenopus laevis in particular, maternal mRNAs involved in the patterning of the secondary body axis are localized to the oocyte vegetal cortex, and upon sperm entry, are subsequently translocated to the future dorsal side. This process, called cortical rotation, is required for the asymmetric activation of the Wnt/β-Catenin signaling pathway on the dorsal side of the blastula. β-catenin, a down-stream wnt effector, regulates the transcriptional activation of dorsal-specific genes at the midblastula transition. Support for the role for β-Catenin signaling in the specification of the dorso-ventral (D/V) axis was garnered from maternal mRNA depletion studies in Xenopus. Recent evidence has suggested that secreted Wnt ligands Wnt11 and Wnt5a may act together in axis formation. However, the function of other maternally expressed Wnts and their cognate receptors (frizzleds) remains uncharacterized. We propose that one or more uncharacterized wnts/fzds act in D/V axis specification. Preliminary analysis of the developmental expression patterns of all wnts and frizzleds (fzds) present in frog, found that wnts 1, 2, 5a, 5b, and 10b and fzds 1, 3, 4, 5, 6, and 7 are expressed in the oocyte, suggestive of a role in D/V patterning. Moreover, maternal fzd1-depleted embryos exhibit a ventralization phenotype and partial defects in dorsal-specific gene expression, while fzd4-depleted embryos exhibit a dorsalization phenotype and an expansion of dorsal specific markers. Further characterization of the genetic factors involved in D/V axis specification could advance the understanding of the pervasive Wnt signaling pathway and provide mechanistic insights into developmental defects.
Changya's Abstract:
Long-Range Chromatin Interactions in Fetal and Adult Hematopoietic Stem Cells
HSCs in fetal liver undergo rapid self-renewal divisions, which lead to a massive increase in cell number of the HSC pool. In contrast, the adult bone marrow HSCs have lower self-renewal capacity. Fetal and adult HSCs display differences in their differentiated cell output. Fetal HSCs have erythro-myeloid lineage output while adult HSCs have balanced lineage output. These differences of biological properties between fetal and adult HSCs correlate with distinct gene expression in HSCs. The transcription factor Sox17 is required for the maintenance of fetal, but not adult, HSCs. Ezh2, a core component of polycomb repressive complex 2 (PRC2), is essential for fetal, but not adult, HSCs. In contrast, Bmi1, Gfi1, Etv6, and C/EBPα are required for restriction of self-renewal in adult HSCs. Several studies have shown that the expression of Sox17 is controlled by long-range chromatin interaction. SUZ12, a PRC2 subunit, can occupy the promoter region of Sox17 and repress its expression in ES cells. In addition, the expression of Sox17 is controlled by polycomb protein and H3K27me3 during pancreatic differentiation. The transcription factor SMAD2/3 can bind to the promoter region of Sox17 and is associated with H3K27me3 depletion to activate gene expression. Ezh2 and Bmi1, aother two polycomb proteins, are also involved into HSCs regulation. It is clear that polycomb proteins are key factors of long-range chromatin interaction. In addition, the expression of Gfi1 is regulated by five regulatory regions with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 as upstream regulators. These indicate that long-range chromatin interaction is essential to the expression of key regulators in fetal and adult HSCs. We currently use 3C-based technologies to identify the long-range chromatin interactions in both fetal liver and bone marrow HSCs.


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text: Two USG Executive Board Positions Open; Elections Scheduled for Saturday St. Thomas Newsroom February 7, 2012 Undergraduate Student Government is planning a special election for the positions of executive vice president and vice president of administrative affairs. Both are paid, executive board positions, and candidates must be juniors or seniors and in good standing with the university to run. Election packets will be available starting today on the USG website and in the Campus Life Office, Room 325, Anderson Student Center. Packets are due back by 8 a.m. Friday, Feb. 10, in the USG office, Room 314, Anderson Student Center. Candidates will give two-minute speeches to the Undergraduate Student Government General Council at 10:30 a.m. Saturday, Feb. 11, in the Woulfe Alumni Hall, with the special election immediately following. For more information about the elections email Mike Orth. Mike Orth sworn in as USG president Undergraduate Student Government announced Sunday that junior Mike Orth, executive vice president of USG, would be stepping in as president, following the resignation of Greg Scharine from the position. Orth was sworn in Sunday at the weekly USG meeting. Orth previously served as freshman and sophomore class president before being elected to the USG Executive Board in April 2011. He will now serve as president of USG and as student representative to the St. Thomas Board of Trustees. Email Jared Scharpen, USG vice president of public relations, for more information. RelatedTwenty USG Positions Open for Election for 2014-15Undergraduate Student Government Now Accepting Applications for Board of Trustees LiaisonsUSG to Conduct Special Elections for Three PositionsUSG Plans Special Election for Vice President of Public Relations


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Childhood of a Circle
"Childhood of a Circle", an animation by Kadavre Exquis. This is a marvelous little film, I only wish it was 200 times longer!
Watch the whole film below!
"Childhood of a Circle", an animation by Kadavre Exquis. This is a marvelous little film, I only wish it was 200 times longer!
Watch the whole film below!
Ugo Gattoni and Mcbess drawing together at Hayward Gallery for Nobrow, a couple months back. Watch the video below!
There is a scene in Efterklang's film "An Island" where the band performs with local people from a small town and although it is obvious that most of them are not musicians they are all playing instruments alongside the band. It is a beautiful scene (I admit I shed a tear the first time I watched it), and I was so inspired by it I began brainstorming ways that I could create a similar experience with bands here in Vancouver. I didn't take the idea any further than my notepad.
Last week I discovered that some fellow Vancouverites have started doing this very thing! They call it Playground. The premise is simple: One band, one audience, one goal. Create a song together, and then record it in less than an hour.
Watch a video of the most recent Playground event below!
Director Joseph Mann opts for puppets instead of computer graphics in this somber video for "Small Hands" by Keaton Henson. The results are pure magic.
Watch the music video below!
Another beautiful hand-painted episode of "Acid Drops", a project by artist Matt Box to "psychedelically capture the individual styles of influential skateboarders". This one features Dylan Rieder.
Watch the hand-painted animation below!
Epic 8-min music video starring Jake Gyllenhaal as a serial killer in a fencing outfit? Yes, please. I love everything Daniel Wolfe directs and this one for The Shoes is another stunner.
Watch the video below! WARNING: This one's fairly violent!
"Full Circle" by Callum Cooper. This is genius, I can't believe I haven't seen this done before.
Watch the video below!
Beginnings is a short film series by Chiara Clemente, and her latest installment features Iranian artist Marjane Satrapi. I love watching any artist draw their signature character so it's a treat to see Satrapi put some ink down as she talks about life many years before her graphic novel series Persepolis became an Oscar-nominated film.
Watch below!