text:
The present invention provides novel biophotonic sensors that have molecular recognition with high sensitivity for target molecules. In one embodiment, the biophotonic sensors have capture moieties with high specificity for molecules of interest (target molecules) and biophotonic conjugates. The biophotonic conjugates exhibit a characteristic photonic activity only when a target molecule is bound. This characteristic photonic activity may include, but is not limited to, either a qualitative response or a measurable change in photonic characteristics upon interaction of the sensors with the target molecules. Methods are also provided for use of the biophotonic sensors to detect molecules of interest either in vitro, in vivo, or in situ.
1. A biophotonic sensor comprising:
a capture moiety wherein the capture moiety has a high specificity for binding a target molecule; and
a biophotonic conjugate wherein the biophotonic conjugate has a characteristic photonic activity when the target molecule is bound to the capture moiety.
2. The biophotonic sensor of
3. The biophotonic sensor of
4. The biophotonic sensor of
5. The biophotonic sensor of
6. The biophotonic sensor of
7. The biophotonic sensor of
8. The biophotonic sensor of
9. A biophotonic sensor comprising:
a capture moiety wherein the capture moiety has a high specificity for binding a target molecule;
a biophotonic conjugate; and
at least one polymer backbone;
wherein the capture moiety and biophotonic conjugate are attached to the polymer backbone such that when the target molecule is bound to the capture moiety, the biophotonic conjugate has a characteristic photonic activity.
10. The biophotonic sensor of
11. The biophotonic sensor of
12. The biophotonic sensor of
13. The biophotonic sensor of
14. The biophotonic sensor of
15. The biophotonic sensor of
16. A method for detecting a target molecule in a sample comprising the steps of:
introducing into the sample the biophotonic sensor of
measuring the photonic activity of the biophotonic sensor.
17. A method for detecting a target molecule in a sample comprising the steps of:
introducing into the sample a biophotonic sensor wherein the biophotonic sensor comprises a capture moiety and a biophotonic conjugate, wherein the biophotonic conjugate has a characteristic photonic activity when the target molecule is bound to the capture moiety; and
measuring the photonic activity of the biophotonic sensor.
18. The method of
19. The method of
20. The method of
21. The method of
22. The method of
The present invention relates generally to biophotonic sensors and more particularly, to biophotonic sensors having both a binding site for target molecules and a biophotonic conjugate.
Sensing systems to probe physiological processes are widely used in research and medical laboratories worldwide. Biosensors in particular have proven capable of high specificity for target molecules. The most widely used biosensors are enzyme based, with commercial applications directed at blood-glucose measurement, pregnancy and fertility testing. However, translating a low level molecular recognition event into a measurable signal can be challenging. Biosensors based on molecular interaction are often limited by insensitivity except at relatively high concentrations, though an ion-channel switch-based biosensor has been used to detect picomolar concentrations of proteins. Recent advances have coupled photonics with biosensors to create a new class of biophotonic sensors that show promise in the non-invasive detection of blood-glucose levels, diabetes, cancer, and bilirubin levels in infants. Rutter, G A, et al., Proc. Nat'l. Acad. Sci. USA, 93: 5489-5494 (1996). These advances all demonstrate the potential that joining the specificity of molecular of recognition with the sensitivity of photonics can have for detection of biologically important molecules.
Biophotonics describes a general class of detection methods that couple biological-based recognition with photonic phenomena. Many different implementations of biophotonics have been utilized to study gene expression (Turner, A. P. F., Nature 387: 555-557 (1997)), adenosine triphosphate (ATP) production (Cornell, B. A. et al., Nature 387: 580-583 (1997)), and measurement of calcium levels in cells with high specificity and sensitivity. However, use of these methods for non- or minimally invasive sensing of molecular targets in vivo has been impractical. In addition to detection of physiological fluid components, a number of biophotonic systems have been developed to probe cellular processes. These include fluorescent and bioluminescent agents for use in reporter gene assays and determination of ATP. For example, U.S. Pat. Nos. 5,532,129 and 6,162,602 disclose modified synthetic nucleic acid polymers into which functional photonic properties are directly incorporated. These modified nucleic acid polymers are used for detecting hybridization to a specific DNA sequence.
Thus it would be desirable to provide a biophotonic sensor combining molecular recognition and biophotonic signaling for both in vivo and in vitro use. Such a device would provide detection of low levels of biomolecule and other molecular targets. It would also be desirable to provide methods for using such devices.
The present invention provides novel biophotonic sensors that have molecular recognition with high sensitivity for target molecules. In one embodiment, the biophotonic sensors have a capture moiety with a high specificity for molecules of interest (target molecules) and a biophotonic conjugate. The capture moiety further has at least one component for binding the target molecule. Preferably, the capture moiety has at least two binding components. Furthermore, the biophotonic conjugate has at least two photonic components. The biophotonic conjugate exhibits a characteristic photonic activity only when a target molecule is bound. This characteristic photonic activity may include, but is not limited to, either a qualitative response or a measurable change in photonic characteristics upon interaction of the sensors with the target molecules.
In another embodiment, the photonic sensors of the present invention may be a single unit or multiple units. In an illustrative embodiment, the components of both the capture moiety and biophotonic conjugate are contained on a single biophotonic sensor unit. In a further embodiment, the biophotonic sensors can either be free in solution or bound to a solid matrix. The biophotonic sensors can be bound to the solid matrix by, but not limited to, hydrophobic interactions, hydrophilic interactions, ionic interactions or covalently bound. Non-limiting examples of solid matrices are multi-well plates, tubes and beads.
Methods for using the biophotonic sensors of the present invention are also provided. The biophotonic sensor is added to a sample, organism or mammal to determine if the desired target molecule is present. Additionally, if desired, the amount of the target molecule that is present in the sample may be determined. In one embodiment, the biophotonic sensor is initially in an inactive state, with minimal or no contact between the components of the biophotonic conjugate. Binding of the target molecule to the capture moiety produces the biophotonic sensor in an active state. In the active state the conformation of the sensor changes such that the components of the biophotonic conjugate will come into close proximity and/or contact with each other, producing photonic activity resulting in a photonic signal. The photonic signal is then collected by a device such as, but not limited to, fiber optic cables, arrays, waveguides or secondary reporting devices. In an alternate embodiment, the biophotonic sensor is initially in the inactive state in which the biophotonic conjugates form a complex prior to binding of the target molecule that deactivates, quenches or gives only background levels of the photonic activity of the biophotonic conjugate. Binding of the target molecule causes the inactive complex to dissociate, generating a biophotonic sensor in an active state.
Additional objects, advantages, and features of the present invention will become apparent from the following description and appended claims, taken in conjunction with the accompanying drawings.
The various advantages of the present invention will become apparent to one skilled in the art by reading the following specification and subjoined claims and by referencing the following drawings in which:
The present invention provides novel biophotonic sensors that have molecular recognition with high sensitivity for target molecules. The biophotonic sensors of the present invention comprise at least one capture moiety which has a high specificity for molecules of interest (target molecules) and at least one biophotonic conjugate. The biophotonic conjugate exhibits a characteristic photonic activity only when a target molecule is bound. This characteristic photonic activity may include, but is not limited to, either a qualitative response or a measurable change in photonic characteristics upon interaction of the sensors with the target molecules.
In one embodiment, the capture moiety has a high affinity and specificity for a target molecule. The target molecule is any molecule of interest that can be bound by the binding components of the capture moiety. The target molecule can include individual molecules, molecular complexes or classes of molecules. Furthermore, the target molecule may be free in solution or it may be immobilized such as, but not limited to, a receptor, glycoprotein or oligosaccharide on a virus capsule or a cell membrane. Non-limiting examples of target molecules are nucleic acid molecules, proteins, enzymes, receptors, metals, coenzyme, small organic or inorganic molecules or any other compound of interest. The capture moiety is comprised of at least one binding component that interacts and/or binds the target molecule. Examples of binding components of the capture moiety include, but are not limited to, antibodies, antibody fragments, enzyme inhibitors, receptor-binding molecules, ligands, various toxins and the like.
In another embodiment, the biophotonic sensors of the present invention comprise at least one biophotonic conjugate. The biophotonic conjugate preferably has at least two components which, when they interact with one another, produce a unique and measurable photonic activity. In a preferred embodiment, the biophotonic conjugate is a fluorescent, bioluminescent, or a chemiluminescent conjugate, and more preferably, a bioluminescent conjugate. In one aspect of the embodiment the system is active and the conjugate produces a signal, preferably fluorescent or luminescent (
In an illustrative embodiment the biophotonic conjugate of the present invention is a fluorescent conjugate. The fluorescent biophotonic conjugates will have components that form appropriate donor and acceptor pairs which are capable of energy transfer by dipole coupling.
A chromophore refers to those groups which have favorable absorption characteristics, i.e., are capable of excitation upon irradiation by any of a variety of photonic sources. Chromophores can be fluorescing or non-fluorescing. Non-fluorescing chromophores typically do not emit energy in the form of photonic energy (hv2). Thus they can be characterized as having a low quantum yield, which is the ratio of emitted photonic energy to adsorbed photonic energy, typically less than 0.01. A fluorescing chromophore is referred to as a fluorophore, and typically emits photonic energy at medium to high quantum yields of 0.01 to 1.
An acceptor chromophore for the purposes of the present invention is a fluorophore that is capable of accepting energy transfer from a donor chromophore and producing an emission spectrum. Because energy transfer by dipole coupling can typically occur when there is an overlap in the emission spectrum of the donor and the excitation spectrum of the acceptor, a �suitable� acceptor typically has an excitation spectrum in the longer wavelengths than its corresponding suitable donor. In this regard, donors and acceptors can be paired for capacity to transfer energy on the basis of overlapping donor emission and acceptor excitation spectra. Therefore, potentially any chromophore can be paired with another chromophore to form an acceptor-donor pair, so long as the two chromophores have different emission spectrums, and have sufficiently overlapping donor emission and acceptor excitation spectra to affect energy transfer.
A non-fluorescent donor producing fluorescent re-emission in the acceptor group is an extremely valuable property. The non-fluorescing donor in a composition of the present invention provides the particular advantage of a low or absent level of emission by the donor, thereby not contributing to background or the detectable emitted light in a donor-acceptor system. Thus, non-fluorescent donors allow for very low background and are particularly preferred. A multiple donor system comprised of such non-fluorescent chromophores would have very little inherent fluorescent background. This property overcomes a major limitation that has severely limited practical uses of fluorescent energy transfer in biophotonic sensor applications. It also opens opportunity to create more useful photonic mechanisms and applications. With regard to unique properties in acceptors, most preferred are acceptors with the highest quantum yields, or with other properties that increase the signal-to-noise ratio between specific acceptor emissions and the background (nonspecific) emissions attributable to the donor. Examples of approaches to reduce the signal-to-noise ratio include using donors having lower emission, preferably non-fluorescing donors, selection of acceptor-donor pairs in which the spectral distance between the emission spectrum of the donor and acceptor is maximized, and preferably selected as to be non-overlapping.
Multiple donors groups (fluorescent and non-fluorescent) transferring energy to a single or smaller number of acceptor groups can be used. Generally, multiple donors transfer to a single acceptor group, but under some conditions and for certain photonic mechanisms more than one acceptor group may be used. The preferred arrangements are those involving the non-fluorescent donors, which provide the important advantage of a low background extended energy transfer process. Other preferred arrangements involve multiple fluorescent donors, excited in the visible region, which transfer to an acceptor(s) which re-emits in the infrared region. This is a useful mechanism because the infrared emission can be detected by optoelectronic devices which are much less sensitive to background fluorescence produced in the visible region.
Chromophore groups with strong quenching properties can also be used to prevent fluorescent emission by the acceptor group. Preferably quenching chromophores are used in biophotonic sensors in which the inactive configuration has the components of the biophotonic conjugate in contact or close proximity with each other. In this embodiment, the present invention contemplates the use of a quencher chromophore (or quencher), that has the capacity to accept, like an acceptor, the transfer of energy by dipole coupling, but does not have significant emission. Although similar in properties to a non-fluorescing donor, the term quencher refers to a non-fluorescing chromophore that is configured to draw the energy potential away from an excited acceptor so that the acceptor does not emit, i.e., the acceptor is quenched.
The mechanism for energy transfer to a quenching chromophore is the same as for donor-donor or donor-acceptor transfer, namely dipole coupling, and therefore is subject to the same requirements as described herein relating to transfer distances and optimum pairing configurations. It is important to point out that the various arrangements and configurations of donor, acceptor, and quencher groups described above can be achieved by either incorporating them within the biophotonic sensor consisting of either a single unit or multiple units.
In an alternate preferred embodiment the biophotonic conjugate of the present invention is a bioluminescent conjugate. The subjects of both chemiluminescence and bioluminescence (visible luminescence from living organisms) have been thoroughly studied. Bioluminescent molecules are distinguished from fluorescent molecules in that they do not require the input of radiative energy to emit light. Rather, bioluminescent molecules utilize chemical energy, such as ATP, to produce light. An advantage of bioluminescent moieties, as opposed to fluorescent moieties, is that there is virtually no background in the signal. The only light detected is light that is produced by the exogenous bioluminescent moiety. In contrast, the light used to excite a fluorescent molecule often results in the fluorescence of substances other than the intended target. This is particularly true when the background is as complex as the internal environment of a living animal.
Several types of bioluminescent molecules are known. They include, but are not limited to, the luciferase family and the aequorin family. Members of the luciferase family have been identified in a variety of prokaryotic and eukaryotic organisms. Luciferase and other enzymes involved in the prokaryotic luminescent (lux) systems, as well as the corresponding lux genes, have been isolated from marine bacteria in the Vibrio and Photobacterium genera and from terrestrial bacteria in the Xenorhabdus genus.
An exemplary eukaryotic organism containing a luciferase system (luc) is the North American firefly Photirius pyralls. Firefly luciferase has been extensively studied, and is widely used in ATP assays. Bioluminescent systems such as the firefly luciferase (FFL) system are particularly interesting for biophotonic applications. FFL catalyzes the oxidation of luciferin in the presence of ATP and O2 to produce oxyluciferin, AMP and green light (λ563 nm). The light produced is very intense, being approximately 1000 times more sensitive than conventional fluorescence techniques. Modified versions of this reaction have been developed utilizing metal ions or coenzyme A to prolong the light emission. cDNAs encoding luciferases from Pyrophorus plagiophthalamus, another species of click beetle, have been cloned and expressed (Wood, et al., Science 244: 700-702 (1989)). This beetle is unusual in that different members of the species emit bioluminescence of different colors. Four classes of clones, having 95-99% homology with each other, were isolated. They emit light at 546 nm (green), 560 nm (yellow-green), 578 nm (yellow) and 593 nm (orange). The last class (593 nm) may be particularly advantageous for use as a light-generating moiety with the present invention, because the emitted light has a wavelength that penetrates tissues more easily than shorter wavelength light.
In a further embodiment, the components of both the capture moiety and biophotonic conjugate are placed on an inert backbone, preferably a polymer. The polymer is a linear polymer or a multibranched polymer such as, but not limited to, star polymers and branched PEGs. The material of the backbone should be inert to the capture moiety and biophotonic conjugate and should have minimal fluorescence and/or luminescence. Furthermore, the backbone should not quench any signal generated by the biophotonic conjugate. Non-limiting examples are PEGs, pluronics, lipids or liposomes. It would also be desirable to have a polymer backbone that is biocompatable and non-toxic to the sample, particularly when the sample comprises living cells or an entire organism such as a mammal.
The capture moiety and biophotonic conjugate are attached to the polymer backbone preferably by tethers or side chains on the polymer backbone (
In another embodiment, the biophotonic sensor of the present invention has the components of both the capture moiety and biophotonic conjugate on more than one backbone polymer (
The biophotonic sensors can also be attached to a solid matrix. Non-limiting examples are styrene or glass beads, tubes, multi-well plates or a gel such as, but not limited to a hydrogel. The sensors can be attached to the solid matrices by, but not limited to, hydrophobic interactions, hydrophilic interactions, ionic interactions or covalently bound. Some advantages of using the biophotonic sensors on a solid matrix are the ease of recovery and also the ability to wash away any non-bound material.
Methods for using the biophotonic sensors of the present invention are also provided. The biophotonic sensors can be used in vitro, in vivo, or in situ for detection and/or quantification of biomolecules and compounds of interest. In one embodiment the biophotonic sensors are mixed into a sample to be assayed. The sample may be, but not limited to, a solution, a serum sample or an environmental water sample. Alternatively the sample is cultured cells, an entire organism or a mammal. For example, U.S. Pat. No. 6,217,547 discloses methods for localization of light emitting conjugates in a mammal. However, unlike the biophotonic sensors of the present invention, the conjugates disclosed in the patent do not require binding of a target molecule to produce a signal. If the biophotonic conjugate is fluorescent, the sample is exposed to an energy source of the appropriate wavelength. If the biophotonic sensor does not produce a strong signal until the target molecule is bound, the sample containing is exposed to the energy source of the appropriate wavelength after adding the biophotonic sensor. Alternatively, if the biophotonic sensor produces a measurable fluorescent signal which decreases upon binding of the target molecule, the biosensor is either exposed to the energy source before being added to the sample or after it has been added. The signal generated by the biophotonic compound in solution is then monitored and collected. Non-limiting examples of devices used for collection of the signal may be, but are not limited to fiber optic cables, arrays, waveguides and secondary reporting devices such as signal amplification with ion channels, electronics or other devices.
It is contemplated that the biophotonic sensors of the present invention can be used in methods to identify the presence of specific biomolecules in a mammal. Particularly, the presence of certain viruses in a patient could be detected using the biophotonic sensors. For example, if a patient exhibited symptoms that could be due to either influenza or the common cold, the biophotonic sensor could be used to distinguish between the two causes for the symptoms. A biophotonic sensor having a capture moiety specific for neuramimidase, a viral coat glycoprotein specific to influenza virus, could be introduced into either a blood sample or to the patient themselves. If a signal is detected then the patient has the influenza virus and appropriate treatment can be administered.
The present invention also provides methods for detecting specific cells and or organelles in an organism, particularly a mammal. For example, a biophotonic sensor with a capture moiety specific for receptors or membrane proteins found in a specific tumor cell line may be administered to a patient. The photonic signal from the sensor would allow for the location of tumors in the patient.
The foregoing discussion discloses and describes merely exemplary embodiments of the present invention. One skilled in the art will readily recognize from such discussion, and from the accompanying drawings, that various changes, modifications and variations can be made therein without departing from the spirit and scope of the invention.
All patents and other publications cited herein are expressly incorporated by reference.
Referenced by
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World Bank Vice President Philippe Le Houérou Arrives Tomorrow
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March 27, 2014
Dhaka, March 27, 2014: World Bank Vice President for the South Asia Region Philippe Le Houérou arrives in Dhaka tomorrow to build on the longstanding partnership between Bangladesh and the World Bank Group, since the country's independence.
This is Le Houérou's first visit to Bangladesh since assuming his position in July 2013 and comes as the World Bank shifts more of its resources in the country to address infrastructure bottlenecks and expand energy generation.
"Bangladesh's remarkable success in reducing poverty is an example for other developing countries who want to achieve the same. But Bangladesh has the potential to do much better," said Le Houérou. "With nearly one-third of the population living in poverty, Bangladesh still faces daunting challenges. By addressing critical development bottlenecks, including in the areas of investment climate, energy and transport, Bangladesh can reduce poverty faster and ensure shared prosperity for its people."
During his visit, Le Houérou will meet with the senior government officials and the private sector and civil society leaders and discuss how the World Bank can best support efforts to make economic development more inclusive while ensuring good governance and strengthening the country's own institutions. He will also visit World Bank financed projects in Bangladesh.
Since 1972, the World Bank has committed more than $17 billion to support the Government of Bangladesh. The World Bank's current portfolio in Bangladesh stands at $6.7 billion with 31 projects.
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subset: commoncrawl


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Rigged this up just the other day while getting ready to clean enough bottles for my brew. Fairly new to the forum, so don't really know if it's been posted or not! BUT it works like a charm!!!
I am not sure what you are showing off. The picture is too small to really make out what it is that you want us to see.
I think he's got a bottle brush attached to a drill...
Yea sorry with the small picture...but it is a Bottle brush attached to a drill.
Yup! That's how I do it. Works great.


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Hoodlum (1997)
Set in 1930s Harlem, this high-octane crime drama told the fictionalized tale of Black gansters fending off Jewish mobster Dutch Shultz from muscling in on their numbers racket. Focusing primarily on legendary hustlers like Bumpy Johnson and Stephanie St. Clair, the film put a retaliatory, blaxploitation slant (the Harlem hustlers never fought back) to a piece of well-known crime history.
On the fifteenth anniversary of the film's release, here's a look at the cast that made a piece of urban history.
(Photo: United Artists Pictures)
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It is my pleasure to present a brand new video from Athens, GA's Casper & the Cookies for the song "Sharp!" from 2009's Modern Silence (one of my favorite albums of last year). I just love this 70's glam influenced song that's really funkier than it has any right to be. Shake it!
(And for you hi-fi folks, check out the vimeo.)
And, if that wasn't enough, they have a bunch of tour dates coming up (including a lot of SXSW awesomeness and a TBA Seattle date)!


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I always try to be honest really and to tell you the truth I wasn't actually going to buy or play Wolfenstein: The New Order. I hadn't planned on it anyway. My brother suggested to make the purchase after he saw the game on CatchoftheDay.com.au for a very generously discounted price ($60 AUD, so about $56.41 USD), so I thought alright, why not, if it's bad it's not that expensive. Full retail of this game is about $99 AUD ($92.72 USD) so yeah, we kinda get ripped off.
Turns out it's not bad, not bad at all! I was pleasantly surprised.
I haven't played Wolfenstein since the original. I remember playing the original Wolfenstein 3D on a PC a long time ago when I was a kid, at my dad's friend's place who funnily enough lives on a farm in the middle of nowhere. Then I remember playing the Super Nintendo adaptation of Wolfenstein 3D where they tried to give it a little bit of a plot, which was just narrated with walls of text in front of a still picture of "B.J" talking to some guy in an office. I won't lie, that sounds wrong.
Wolfenstein: The New Order pits players into the first person shoes of Captain William "B.J" Blazkowicz (I think that's how you spell his name), a former Sergeant of the U.S Rangers who now serves as an agent of the U.S. Special Forces. The game immediately throws you into an epic battle, storming a base of Nazi General Wilhelm "Deathshead" Strasse. Shortly after storming the base, you're captured by Deathshead himself, you're forced to choose one of your comrades to die gruesomely right in front of you, then you manage to make your escape before B.J suffers a head injury that puts him in a vegetative state. This is all in the first level by the way, you know, the tutorial of the game.
Fast forward fourteen years later, B.J is in a Polish mental hospital where he is being treated. The hospital is stormed by Nazi soldiers and somehow, B.J is able to break free from his vegetative state and begins to do what he does best. Killing Nazis. Upon his escape from the hospital, B.J learns that the year is 1960 and at the end of World War II, the Nazi's won.
The plot is well told and there is actually a fair amount of decent writing and voice acting, particularly for B.J, however, what I will complain about is this, how is it after fourteen years of being in a vegetative and immobile state is B.J still a hulking Nazi killing machine? Were they feeding him steroids and making his body do weights, or something? I don't know but I'll try not to let that get in the way.
Wolfenstein: The New Order reminds me of three games I've played in the past mixed into one and that's not necessarily a bad thing. It reminds me of Call of Duty 4: Modern Warfare, The Chronicles of Riddick: Escape from Butcher Bay and 007: Nightfire. It's a first person shooter, with tight controls, unlimited sprinting, the ability to jump, climb over obstacles, crouch, slide across the ground and so forth. You can fire your guns from the hip, fire from the iron sights like Call of Duty and you can dual wield weapons. I didn't really experience any problems with the controls at all. You can also melee with a knife or if you're quiet enough, take out bad guys from behind with brutal and somehow quiet take downs.
One feature I liked was the ability to lean, which was common in first person shooters of the past but not so much now. Leaning allows you to take cover behind objects, whether it's a wall or a corner, and you can lean out either left, right, up or even down and fire at the enemy. Leaning is also useful in stealth segments, as you can approach a corner and lean to the side to survey the area for any enemies. It's a nice welcome back feature that I used often.
What adds further challenge to the game is health and armour and how it works. Unlike most modern shooters of today that utilize some form of health regeneration, Wolfenstein: The New Order returns to its roots and once again, players now have to be wary of their health and armour. To restore health, players must find health packs to heal them, while armour can be found scattered throughout levels and collected off some fallen enemies. Armour does as it's called, it protects your health from being harmed and it is a very handy thing to have. It's possible to upgrade your health by finding certain collectables and if you collect enough health packs, you can enter a "supercharge" mode that basically means for a short duration of time, you can have more health than your maximum allows. This can be handy for vicious fire fights.
I will make a note though, dual wielding weapons is only fun for about five minutes then it loses the appeal very quickly. Dual wielding weapons makes you slower and you lose the invaluable option to aim down the iron sights. You're better off sticking to just one gun.
To my surprise there is a fair emphasis on stealth, however that being said, once you're spotted stealth will pretty much immediately be thrown out the window with no chances of hiding and relocating. As long as you can take out the officers who are capable of calling in reinforcements, you'll be fine. You can tell when you've entered an environment where it's intended for stealth. Guards are fairly isolated from one another, allowing you careful opportunity to take them out quietly one at a time with your knife, or throwing knives if you have any. You can also acquire a silencer for your pistol at some stage, which makes stealth very easy, as the pistol seems to have limitless range if careful accuracy is used. It's fun stealth and there's nothing really wrong with it, it's just not as in depth as say Metal Gear Solid or Splinter Cell.
There's a fair amount of variety for the most part in regards to enemies and environment. You'll be breaking into Nazi strongholds and prisons, swimming and exploring sewers and so forth. It's a pretty interesting game. There's a fair amount of enemies too from Nazi soldiers, to riot guards, to officers, dogs and giant robots. Fun stuff. Yup. The Nazi's have robots and lots of them. I was a little disappointed by the weapon variety though, there really isn't much and it really depends on what level you're in that determines what weapons you acquire. Most of the time I used the knife, silenced pistol or assault rifle, they worked out most of the time and only rarely did I have to find and use something else to take down a particular enemy. Don't get me wrong, I enjoyed it, but I fear that players may feel a bit "meh" at the lack of weapon variety. Some weapons you can only get on particular levels for particular situations.
Wolfenstein: The New Order introduces a Perks system, which kind of reminds me of an RPG in a way mixed in with achievements. There are categories, or trees of Perks. You've got Stealth, Tactical, Assault and Demolition. Each category has its own number of Perks, which act as upgrades as long as you can unlock them. Unlocking them works in a similar way as to achieve trophy/achievements, for example, to unlock the 'Assassin' Perk, you must silently take down up to fifty enemies and ten dogs (I think, or it might be five, I might have the numbers wrong). Once you've done this, you've permanently unlocked the Assassin Perk, meaning you're quieter when you run and when you sneak (crouch walk) you move faster. Very handy.
I mentioned a spoiler before that involves the player being forced to choose between saving one character and letting the other one die. Well, the reason I mentioned this is because depending on who you save actually allows a new skill. Should you save one character, you'll receive the ability to hot wire devices to unlock new things. Should you save the other? You'll receive the ability to pick lock certain doors and access new paths. In regards to the storyline, saving either or character doesn't really change anything.
The overall presentation of Wolfenstein: The New Order is quite impressive. Environments are quite large and detailed and the world of Post Nazi victory is not only imaginative, but down right disturbing. This is one of the most intense shooters I have played, with some very, literally in your face moments of violence, fear and gore. This is game is certainly not for the faint of heart. Guns feel heavy, guns are loud and explosions are loud. The soundtrack is pretty damn impressive too, particularly at the title screen. Most of the voice acting and dialogue is quite good too. This is a good looking game and it sounds good.
Sadly, there isn't much to collect in terms of collectables. You can find statues that increase your maximum health and you can unlock character trophies (3D models) that include brief biographies and and you can get concept art to check out too. There's also Enigma codes scattered throughout the game, which apparently if you collect them all you can unlock in-game content. What this content is though, I have no idea, so I can't tell you if it's worth it or not at this stage.
Despite my surprise and praise of this game, there's a few things that fall a little.
Apart from B.J, most of the characters feel quite undeveloped and they really aren't that interesting. Some of them are sure, but most of them aren't. Which is a shame, considering this is probably the best written Wolfenstein game and they wanted to expand on narrative, this is a missed opportunity.
Enemy A.I can at times be a bit hit and miss. Sometimes the enemies are ruthless and will really put the pressure on the player. Sometimes though, they'll just stand there and wait for you to shoot them in the head. It's unpredictable, but not in the best way.
Personally, while this game is fun and action packed, I felt at times it can be a bit repetitive. I found I could only play the game for an hour or so, then I would have to take a break and probably play the next night or so. I'm sure some players will disagree to this and could binge through it and finish it in a night (considering the game play probably lasts about ten to fifteen hours), but I'm not one of those people.
There's only a few vehicle sections, but truthfully I hated these segments and to me it was probably the worst thing about the game. The vehicle segments are painfully forced and the controls don't feel so tight or sharp anymore. I would love to avoid these but unfortunately you've just gotta push through them. There's a couple of quick time events on foot too but thankfully, not much at all.
Finally, since it's a single player only game, there's not much to come back to upon the completion of Wolfenstein: The New Order. Sure, you could revisit levels to search for stuff you may have missed, such as Enigma codes or maximum health trophies, but there's not much to go back for. If you're a big fan of this game and a masochist, you could revisit the already challenging game and try it again at a harder difficulty.
Wolfenstein: The New Order is a pleasant surprise. What I find funny and kind of ironic is despite being a shooter made in 2014, it feels very new and fresh all because it revisits old school gaming, reintroducing health and armour, the ability to learn and so forth, while it mixes in new elements of today, such as the Perks system. I'm actually glad I picked this game up.
Wolfenstein: The New Order is available now on PC, X-Box 360, X-Box One, PS3 and PS4 consoles.
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Daniel A. Bloom
Dan is a member of Pachman Richardson, LLC, where he practices family law and serves as a mediator, arbitrator and Guardian Ad Litem. From June 2001 through May 2006 Dan was a Magistrate Judge in Fulton County, where he was specially assigned to the Family Division.
Practice Areas
Family Law; Collaborative Family Law; Matrimonial Law; Divorce (contested and uncontested); Support, including Alimony and Child Support; Modification, including Custody, Child Support and Alimony; Prenuptial Agreements; Separation Agreements; Settlement Agreements; Paternity; Legitimation; Name Change; Mediation; Arbitration, including Arbitration of Custody Disputes; Case Evaluation; Guardian ad Litem.
Bar Admissions
- Georgia 1995
- Emory University School of Law, J.D., 1994
- Tulane University, B.A., 1989
Honors & Awards
- Selected for inclusion in The Top 100 Lawyers in Georgia Super Lawyers 2012
- Selected for inclusion as a Georgia Super Lawyer 2010, 2011, 2012
- 2002-2003 Families First Award from the Atlanta Bar Association
- 2005 Outstanding Service to the Stonewall Community Award
- Named one of Georgia's Legal Elite 2007, 2008, 2010
Associations & Accreditations
- State Bar of Georgia, Family Law Section
- Atlanta Bar Association, Family Law Section, Board of Directors
- Chair Elect, Family Law Section of the Atlanta Bar Association
- Stonewall Bar Association
- ACLU of Georgia Board of Directors
- Partnership Against Domestic Violence Board of Directors
- Emory Public Interest Committee; Advisory Board, Emory Law School
- Lawyers Club of Atlanta
- Collaborative Law Institute of Georgia
- International Academy of Collaborative Professionals
- Association of Family and Conciliation Courts
- Certified Mediator
- Certified Arbitrator
- Guardian Ad Litem
Publications & Seminar Presentations
"Domestic Violence and the Collaborative Law Practice," The Collaborative Law Institute of Georgia, April 11, 2008
"Parenting Plans Under O.C.G.A. §19-9-3 – Just Do It – Right!," Atlanta Bar Association, February 14, 2008
"Legal Representation in Domestic Relations Cases where Family Violence is a Factor," Association of Family and Conciliation Courts, September 27, 2007
"House Bill 369 and Parenting Plan Skills Training," The Collaborative Law Institute of Georgia, August 24, 2007
"Custodial Issues Unique to Same-Sex Couples," Atlanta Bar Association, August 18, 2006
"Domestic Unions – Taking a Look at the Challenges and a Preview of What is on the Horizon," American Bar Association, September 30, 2005
"The Guardian ad Litem – Resolving Custody Without Litigation," Atlanta Bar Association, October 28, 2004
"Critical Partnerships in Representing Children in Custody Cases," American Bar Association, April 17, 2004
"Nuts and Bolts of Being a Guardian ad Litem," various dates over last 8 years
"Domestic Violence and its Impact on Children," various dates over last 10 years


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"good company, perception by customers is that you're starting to loose it, since merging with Ricoh UK "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I worked at NRG UK
recognised company, good products, freedom to do job. if you're in the right job and team, the morale can be good.
bad work/life balance, average career opportunities, pay not enough for hours and effort put in.
look after dedicated knowledgeable staff or they'll leave. How can you spend millions on 'improving the system' and in the meantime keep your customers and staff in the dark
2 Other Employee Reviews for NRG UK (View Most Recent)Sort: Rating Date
"A fulfilling, fun and learned experience "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I worked at NRG UK full-time (more than 3 years)Pros
Well i was lucky enough to run scotland for the Indirect Operations of NRG, we had a fantastic team who looked after each other, we fed from one and other and most of all we hit our targets and i also had some fantastic dealers in ScotlandCons
the only con would have been lack of tech support in the scottish region and the fact our board in Japan were working from figures and not really getting a foothold on the economic downturn that Britain was heading into at that time!!!Doesn't RecommendNeutral OutlookApproves of CEO


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May 7, 2013
Ford Commercial Truck is replacing its annual Tough Truck Sweepstakes with a contest – the Tough Truck Challenge – which gives business owners the chance to win a brand new work truck.
Entrants will be given a chance to convince a selection committee, and the public, that their business deserves the Grand Prize Super Duty Pickup.
Participants are encouraged to make their case in 300 words or less by describing their business, goals, and current commercial vehicles in an original way. The submission Period began April 15 and ends August 31.
The top 10 entries will be posted and put to a vote on the Ford Trucks Facebook fan page and fordtoughtruck.com – where the public will decide who wins.
First place is a 2014 Ford F-250 Super Duty. Second place is a trip to a Las Vegas trade show and $1,000 American Express Gift Card, and third place is a $1,000 American Express Gift Card.
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
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Mark Whicker column.
CARSON – The loser, Mike Alvarado, stared blankly, not quite processing the fact that the curtain came down.
The winner, Brandon Rios, ran to a far corner and then fell on his chest, either sobbing or convulsing, as his handlers converged.
The referee, Pat Russell, stood defiant after he had taken four remaining rounds of indescribably sweet candy away from a sellout crowd at The Home Depot Center.
He was thinking straighter than anyone else in The Home Depot Center, a sold-out madhouse on this Saturday night, when boxing rose to its eternal paradox. The closer it approaches disaster, the more beautiful it gets.
"This was a great, great fight," Russell said in a corridor near the locker rooms. "But this kid (Alvarado) is a great fighter. A year from now, I want him to be walking around.
"I was going to take him into deep water, but I wasn't going to let him drown."
For nearly seven rounds Rios and Alvarado flooded this ring with nose-to-nose savagery, like dump trucks crashing into each other time after time. The area around the ropes was extraneous, for the most part. So, until the very end, was Russell.
In every round of the replay that you absolutely must watch, you will see the pride and joy of championship boxing.
You will see Alvarado, who came in 33-0, battering Rios with right leads and right-on combinations. You will see Rios endure that abuse and return with his signature uppercuts, his right hands that somehow sprang fresh out of misery and pain.
"Look at their faces," Russell said. "I don't think they ever missed each other."
But when the deal came down, Russell was poised. Rios got Alvarado with a showy right hand that got his Oxnard fans excited, but a more damaging blow was a quieter right to the nose.
Rios followed it with a chopping right that finally broke Alvarado's defense, that spun him bewildered toward the ropes. Now 30-0-1, Rios is a merciless shark at those moments, and Russell stopped the fight before Alvarado went down but also before he couldn't get up.
"I heard him (Russell) talking to Mike in the ring," Rios said, standing in the hallway as a doctor was checking out his swollen forehead.
"He said, come on. Hit him. Nothing was happening. I know Mike's a warrior like me. If he's going to lose he wants to go down fighting."
Alvarado, observing boxing custom, said it shouldn't have stopped but didn't seem real convincing. His trainer, Henry Delgado, was even more equivocal.
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Samsung Group
"Fantastic "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at Samsung Group
Good place to work. nice recognition and feedback for our effort. Package is worth compared with other good product companies
Time schedule is very hectic. All maintenance project. Not many scratch development projects. All projects depends on Head quarters.
844 Other Employee Reviews for Samsung Group (View Most Recent)Sort: Rating Date
1 person found this helpful
"was quite unsatisfactory "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at Samsung GroupPros
telecom industry is very competitive and innovation is appreciatedCons
but there is a very small marketshare to vie for and the competition is hectic and this makes the work-life balance awryAdvice to ManagementAdvice
in india, i worked for samsung and i found quite a number of glorified managers who were not hands-on and had no knowledge of how to run an Agile mobile development platform . samsung needs better managers.Doesn't RecommendDisapproves of CEO
1 person found this helpful
"Incompetent yet Arrogant as far as Software aspects are concerned "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I worked at Samsung GroupPros
Compensation , Benefits
As long as u obey n sit in the office for 10+ hours, u are safe.Cons
1. Incompetent Bosses who hardly know anything about Computer Science
2. Incapable of Learning New Stuff, Lack of Smart People; Mostly Follow Orders and Work in a Military Style
3. Not a place for people who take work seriously particularly in the SW Domain
4. Bunch of incompetent sycophants n managers pretending to be Engineers n ResearchersAdvice to ManagementAdvice
Get rid of useless Principal Engineers who cannot create ideas or learn new stuff. Its a bunch of Managers pretending to be Engineers n Researchers. The hierarchical military style work is destroying creativity.Doesn't RecommendNo opinion of CEO


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Book Description:Mags, a young Herald trainee in Haven, the capital city of the kingdom of Valdemar, has talents not commonly found in Herald trainees. Recognizing this, the King's Own Herald decides to train Mags as a spy in order to uncover the secrets of a mysterious new enemy who has taken an interest in Mags himself. Why is the even deeper mystery. The answers can only be found in the most unexpected corners of Mags' past...assuming he can live long enough to find them.
Buyback (Sell directly to one of these merchants and get cash immediately)
One fine body…
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Senior Member
1.4% of a free account community.
Junior Member
Hi all,
I think the majority of players are good. I think the "baddies" who need to be punished often do get punished but I think banning a account is a waste of time. It should be a I.P. ban that way the offender can't just make a new account. I have seen a player get banned then 15 min later he is on another account doing the same thing. If you ban just his "troll" account he can make another, if you ban all his accounts he is done and will never harrass another person. Some may argue that there may be multiple people using one computer and it's not far to the (good) players. My response would be tough $@(^. It isn't far to the rest of us who play with respect to others that you can just make 20-30 accounts with total disreguard if you get banned.
I think Riot should set up some "Dummy" cases where there is no clear evidence. use them as a test.
See how long people take to vote see if people just click "punish" even if it is unwarented...
i have voted on many cases, i read through the chat logs and believe it of not i get a email saying that i didnt choose like the majority. there are cases where someone is in fact being trolled the WHOLE match and just because there are three ******s that joined together the reported person is automaticly guilty.
sorry for the spelling.
This is weird
Id like to see a way to vote someone up - positively. So when Player A has been threatening to report Player B all game for no good reason, you can show some support for Player B being wrongly harrassed.
Another awesome idea would be to downgrade the value of people who report the most. Some people are just *******s and whining is their excuse for not getting better in-game.
Wouldn't you agree that a player who reports 1 or 2 players every match, has little to contribute?
it seams an on going epidemic of leavers over half the games played lately have had either leavers at the beginning or worse leavers at 12 to 15 level in the game. These people are reported of coarse but does it do any good it runs the game and all say should be banned longer that the 5 min i agree offenders should be 5 min first offense but habitual offenders should be banned for 24 hours and should be auto .
just wondering was talk of one day being able to combine accts that had money put into is there ever going to be such a time thanks wam
i like that option just because one player has a problem or blames another should not be reported false reasons
They are just over powered because they spend too much time playing video games i don't under stand how leaving a game ruins it for the other players and if you perma ban me then it just show that you are not apart of America because in America we have the right of free speech. so shut me you communist animals!
Chairman Moo
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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MOVIEmeterSEE RANK
Up 56,347 this week
Body and Soul (1927)
- Drama | Romance - 1 October 1927 (USA)
(awaiting 5 votes)
Reviews: write review
A disgraced alcoholic surgeon settles in a small village in the Swiss Alps. He falls for Hilda, a servant at the hotel where he lives. He tricks her into marrying him by making her think ... See full summary »
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Jeffrey Ross on James Holmes Roast Joke: Not Really Sorryby Free Britney at . Comments
During the taping of Comedy Central's roast of Roseanne Barr Sunday, Jeffrey Ross turned to Seth Greene and congratulated him on a "really big night." Why?
"You haven't gotten this much attention since you shot all those people in Aurora," the comedian joked in reference to alleged killer James Holmes, adding:
"I'm kidding! You're nothing like James Holmes. At least he's doing something in a movie theater that people remember."
Yeah. How did he respond to the obvious backlash?
Ross admitted that "Yes, I crossed a line" but that this is "what the roasts are all about. That's what Roseanne is about ... unapologetic comedy."
"If I had held back, I would have done her a disservice."
As for Ross' disservice to the Colorado shooting victims, producer Jonas Larsen has already said the jokes will be cut from the August 12 telecast.
If Ross is at all sorry, he's not exactly showing it.
"In these particular times - it is important to exercise freedom of speech," he added. "Comedians are apologizing a lot. I am not saying that is right or wrong."
"But it scares me when I start second guessing myself. I wanted to put it out there and remind people what America is about, and on some level, what roasts are about."
"When I was a kid I said whatever I wanted. It was one of my favorite things about America," he added. "So now I feel like I am a big kid."
As for his second most controversial move of the night - dressing like disgraced Penn State football coach Joe Paterno - Ross said he doesn't care.
What do you think of Ross' jokes about James Holmes?
It has nothing to do with freedom of speech. Surprisingly, he is not intelligent enough to distinguish between freedom of speech (when and what is appropriate) and plain human TACT and compassion. The guy lacks some depth instead of shallowness.
Would this troll be making a joke about the Colorado shootings if the shooting was in a synagogue? Don't think so and Barr would not have found it to be funny.
Not at all funny this close to the tragedy. Jews can make jokes about the Holocaust, Muslims can make jokes about Allah. That's the rule of great comedy. If anyone ever wants to joke about James Holmes, let it be the victims alone. I have no respect for this level of insensitivity. I am not from America, but I lived there for seven years once. I love your country, and the bulk of your people, but you take this freedom of speech TOO FAR, just as you take your "RIGHT TO BEAR ARMS" WAY WAY WAY TOO SERIOUSLY!! Okay, so I am going to break my own rule about telling jokes now. Have you heard this one? "THE USA IS THE GREATEST INSANE ASYLUM ON PLANET EARTH- RUN BY THE INMATES". Just kidding... ha ha ha lol!
This guy is noted for being one of the most caustic comedians at any roast. If you can't take the heat, get out of the kitchen.
Too bad Jeffrey Ross was not one of the victims, since he thinks it is funny. What an ugly troll he is - inside and out.


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Collection System - Facility Management Product Release
Grasshopper Co.
website | Company information
The HighLift™ empties from a raised position at the flip of a switch. It has a maximum vertical emptying height of 72 inches, allowing operators to empty clippings and debris into an elevated space, such as a pickup bed or trailer. The rear-mounted collector and deck-mounted Quik-D-Tach® vacuum retain the mower's zero-turn maneuverability. The vacuum picks up debris without the need for an auxiliary engine and requires no tools for removal. The collector has a 15-foot capacity and a tapered bottom that compacts debris for continued productivity and fewer stops.
Content Category: Grounds Management
- Anti-icing vs. Deicing: Applying Industrial Snow Melter
- Green Landscaping Best Practices
- Lawn Mower Maintenance: Ensure Safe, Reliable Operations
- Options Abound for Lawn Mower Attachments
- Snow & Ice Removal Equipment: Develop an Arsenal
- Strategies for Developing a Fleet Management Program
- Techniques for Establishing Effective Bird Control Systems
- Utility Vehicle Accessories Expand Grounds Operations
- What Task Can a Turf Maintenance Vehicle Not Perform?
- Mower Maintenance Plan Helps Extend Life of Fleet
- Follow Manufacturer's, Warranty Guidelines to Extend Mower Shelf Life
- Keeping Employees Safe Top Priority of Mower Fleet Management
posted: 5/29/2014
Search Collection System on FacilityZone.com


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Playstation 3
Secret Trophies for Split/SecondHome / Playstation 3 /
This page contains Split/Second Unlockables for Playstation 3 called "Secret Trophies" and has been posted or updated on May 27, 2010 by johnjerick. Let us know what you think of this Unlockable by thumbs voting.
- Developer: Black Rock Studio
- Publisher: Disney Interactive Studios
- Genre: Driving General
- Release Date: May 18, 2010
- ESRB: Everyone 10+
Secret Trophies
To unlock the following PS3 Trophies, complete the following tasks:
|How to Unlock:
|Better Luck Next Time (Bronze)
|Get wrecked by a shortcut that a rival has triggered.
|Bully (Silver)
|In an event, wreck every rival with a Power Play.
|Cheapskate (Bronze)
|Use a shortcut that a rival has triggered.
|Convoy (Silver)
|Overtake 12 trucks in a row without crashing in a Survival event.
|Eliminator Efficiency (Bronze)
|Win an Elimination event by being in 1st place at each elimination.
|Fearless (Bronze)
|Overtake 5 trucks in a row during Sudden Death in a Survival event.
|Follow Me (Bronze)
|In an event, change the track twice with a Route Changer Power Play.
|Frequent Flyer (Bronze)
|In an event, wreck 3 rivals by crash landing a plane.
|High Pipe (Bronze)
|In an event, wreck 3 rivals by demolishing a cooling tower.
|Once, Twice, Three times Evasive (Bronze)
|Get three Perfect Waves in a row in either a Air Strike or Air Revenge event.
|Rope A Dope (Bronze)
|With 5 seconds or less on the clock, escape from last place and certain elimination.
|Shipwrecked (Bronze)
|In an event, wreck 3 rivals by launching a ship sideways across the track.
|Split/Second (Bronze)
|Win a Race event by less than a second.
|Swept Away (Bronze)
|In an event, wreck 3 rivals by destroying a dam.
|Team BlackRock (Bronze)
|Beat a member of the development team or someone who has beaten them.
|The Pain Train (Bronze)
|In an event, wreck 3 rivals by derailing a train.
|Untouchable (Bronze)
|Win a Race event without crashing.
|Zero To Hero (Bronze)
|Use a route changer to go from 8th to 1st place.
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Serving Christ Together
A Message from the DS
I am really enjoying our Charge Conferences this year. I have been hearing many inspiring stories of churches who are reaching out in new and exciting ways. Thank you for sharing your ministries with me.
As I have listened to your reports I have realized how important sharing our story is - not from a self- glorifying perspective, but recognizing and celebrating what God is doing in and through us. We need to do more story-sharing in our church ministry and in our own personal lives. We need to articulate how God is working in us. The old hymn says, "We've a story to tell to the nations that shall turn their hearts to the right, a story of truth and mercy, a story of peace and light. For the darkness shall turn to dawning and the dawning to noonday bright; and Christ's great kingdom shall come to earth, the kingdom of love and light."
I have also become aware of our misunderstanding of the word "evangelism." Evangelism is not about just getting more church members, it is about sharing the message of Christ with others. Inviting new people to church is important, but if all we are hoping for is to add people to our rolls so that our church looks good, we are missing the true meaning of Christ's call to make disciples to the ends of the earth. Christ's call is to share love, peace, and new life to a hurting world and the church is the facilitator of that call. We need to take it very seriously.
I look forward to continuing my travels around the district and hearing your stories. They enrich my life!
SPR & Finance Workshops
On Thursday, November 13 the District Office will offer 2 training sessions for SPR Committee members and Finance Committee members. The training event will be held at LaGrange First UMC at 7pm in the Methodist Ministries Center. District Superintendent Carol Cook will lead the SPR workshop and District Administrative Assistant Denise Wilson will lead the Finance workshop. Both will focus on the duties and responsibilities of these two required committees. Be sure that your church is represented at both!
District Connection Groups
We have begun the District Connection Groups! Every church in the LaGrange District has been assigned to a group and one clergy from each group has been designated as the group leader. (Click here for a list of the groups and leaders.) Groups should now be meeting to plan activities for the coming year. These groups will provide an opportunity for clergy and laity within close geographic proximity to get together for fellowship, worship, and mission projects. If you have not seen information about these activities, check with your pastor.