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Publications (98)359.16 Total impact
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ABSTRACT: Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, yet the functions of the individual groups are not fully understood. Adrenergic C3 neurons project widely throughout the brain, including densely to sympathetic preganglionic neurons in the spinal cord, yet their function is completely unknown. Here we demonstrate in rats that optogenetic stimulation of C3 neurons induces sympathoexcitatory, cardiovasomotor functions. These neurons are activated by glucoprivation, but unlike the C1 cell group, not by hypotension. The cardiovascular activation induced by C3 neurons is less than that induced by optogenetic stimulation of C1 neurons; however, combined stimulation produces additive sympathoexcitatory and cardiovascular effects. The varicose axons of C3 neurons largely overlap with those of C1 neurons in the region of sympathetic preganglionic neurons in the spinal cord; however, regional differences point to effects on different sympathetic outflows. These studies definitively demonstrate the first known function of C3 neurons as unique cardiovasomotor stimulatory cells, embedded in the brainstem networks regulating cardiorespiratory activity and the response to glucoprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience. 11/2014; 34(45):15110-22.
Article: Angiotensin type 1A receptor expression in C1 neurons of the rostral ventrolateral medulla contributes to the development of angiotensin-dependent hypertension[Show abstract] [Hide abstract]
ABSTRACT: Chronic low dose systemic infusion of angiotensin II induces hypertension via activation of the angiotensin II type 1A receptor (AT1AR). Previously, we have demonstrated that expression of the AT1AR on catecholaminergic neurons is necessary for the full development of angiotensin-dependent hypertension. In the present study, we examined the mechanism by which selective deletion of the AT1AR from these cells affects the development of hypertension. We also tested the hypothesis that AT1AR expressed by catecholaminergic C1 neurons in the rostral ventrolateral medulla play an important role in angiotensin II hypertension. A Cre-lox approach was used to delete AT1AR from all catecholaminergic cells or from C1 neurons selectively. Subcutaneous administration of angiotensin II induced hypertension in all mice, with delayed onset and reduced maximal response in the global AT1AR catecholaminergic knockout. The AT1AR catecholamine knockout mice had decreased renal fluid and electrolyte retention and urinary noradrenaline excretion. The blood pressure response was only reduced during the second week of angiotensin II infusion in the selective C1 AT1AR deletion, demonstrating that AT1AR expression by C1 neurons plays a moderate role in angiotensin-induced hypertension. The difference in the time course of hypertension development between the global AT1AR knockout from catecholaminergic cells and the C1 AT1AR deletion mice suggests that other catecholamine neurons are important.This article is protected by copyright. All rights reservedExperimental physiology 09/2014; · 3.17 Impact Factor
Article: Identification of CNS neurons with polysynaptic connections to both the sympathetic and parasympathetic innervation of the submandibular gland.[Show abstract] [Hide abstract]
ABSTRACT: Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distribution would enable coordinated regulation and might suggest individual premotor neurons could project to both sympathetic and parasympathetic outflows. To investigate this one submandibular gland was sympathectomized. One of two isogenic strains of the pseudorabies virus, expressing different fluorophores, was injected into the cut sympathetic nerve and the other into the submandibular gland. Independent labeling of the peripheral sympathetic and parasympathetic pathways was observed. Dual-labeled neurons were observed in many CNS regions known to be involved in regulating salivary function. We propose these observations highlight a common pattern of organization of the CNS, providing the anatomical framework for the fine control of organ function required for homeostatic regulation and the coordination of organ responses to enable complex behaviors.Brain Structure and Function 05/2014; · 7.84 Impact Factor
Article: Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice.[Show abstract] [Hide abstract]
ABSTRACT: Therapeutic targets for male contraception are associated with numerous problems due to their focus on disrupting spermatogenesis or hormonal mechanisms to produce dysfunctional sperm. Here we describe the dual genetic deletion of α1A-adrenergic G protein-coupled receptors (adrenoceptors) and P2X1-purinoceptor ligand gated ion channels in male mice, thereby blocking sympathetically mediated sperm transport through the vas deferens during the emission phase of ejaculation. This modification produced 100% infertility without effects on sexual behavior or function. Sperm taken from the cauda epididymides of double knockout mice were microscopically normal and motile. Furthermore, double knockout sperm were capable of producing normal offspring following intracytoplasmic sperm injection into wild-type ova and implantation of the fertilized eggs into foster mothers. Blood pressure and baroreflex function was reduced in double knockout mice, but no more than single knockout of α1A-adrenoceptors alone. These results suggest that this autonomic method of male contraception appears free of major physiological and behavioral side effects. In addition, they provide conclusive proof of concept that pharmacological antagonism of the P2X1-purinoceptor and α1A-adrenoceptor provides a safe and effective therapeutic target for a nonhormonal, readily reversible male contraceptive.Proceedings of the National Academy of Sciences 12/2013; · 9.81 Impact Factor
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ABSTRACT: The baroreceptor reflex dampens the short-term fluctuations in blood pressure by feedback modulation of heart rate (HR) and vascular resistance. Impairment of this reflex has been observed in hypertension and heart failure. Angiotensin II, a blood borne hormone, acts via its type 1A receptor to attenuate the baroreceptor reflex and this reflex is reported to be dramatically altered in angiotensin type 1A receptor knockout mice. This study sought to further investigate changes in the arterial and cardiopulmonary baroreceptor reflex control of HR in angiotensin II type 1A receptor knocked out mice. In artificially ventilated, isoflurane anesthetized mice, the arterial and cardiopulmonary baroreceptor reflexes were activated via injection or slow infusions, respectively, of phenylephrine and sodium nitroprusside through the jugular vein. We observed no impairment of either the arterial or cardiopulmonary baroreceptor reflex control of HR in angiotensin type 1A receptor knockout mice.Physiological reports. 11/2013; 1(6):e00171.
Article: Stimulation of Angiotensin Type 1A Receptors on Catecholaminergic Cells Contributes to Angiotensin-Dependent Hypertension.[Show abstract] [Hide abstract]
ABSTRACT: Hypertension contributes to multiple forms of cardiovascular disease and thus morbidity and mortality. The mechanisms inducing hypertension remain unclear although the involvement of homeostatic systems, such as the renin-angiotensin and sympathetic nervous systems, is established. A pivotal role of the angiotensin type 1 receptor in the proximal tubule of the kidney for the development of experimental hypertension is established. Yet, other systems are involved. This study tests whether the expression of angiotensin type 1A receptors in catecholaminergic cells contributes to hypertension development. Using a Cre-lox approach, we deleted the angiotensin type 1A receptor from all catecholaminergic cells. This deletion did not alter basal metabolism or blood pressure but delayed the onset of angiotensin-dependent hypertension and reduced the maximal response. Cardiac hypertrophy was also reduced. The knockout mice showed attenuated activation of the sympathetic nervous system during angiotensin II infusion as measured by spectral analysis of the blood pressure. Increased reactive oxygen species production was observed in forebrain regions, including the subfornical organ, of the knockout mouse but was markedly reduced in the rostral ventrolateral medulla. These studies demonstrate that stimulation of the angiotensin type 1A receptor on catecholaminergic cells is required for the full development of angiotensin-dependent hypertension and support an important role for the sympathetic nervous system in this model.Hypertension 09/2013; · 6.87 Impact Factor
Article: Cardiovascular role of angiotensin type 1A receptors in the nucleus of the solitary tract of mice.[Show abstract] [Hide abstract]
ABSTRACT: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A receptors (AT1AR). To assess function, we examined the effect of expressing in AT1AR in the NTS of mice lacking these receptors. Bilateral microinjections of lentivirus expressing AT1AR (AT1Av mice, n=6) or green fluorescent protein (GFPv, n=8, control) under the control of the PRSx8 promotor, were made into the NTS of AT1AR null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR) and locomotor activity. Expression of AT1AR in the NTS increased BP by 11.2±4 mmHg (P<0.05) at 2 and 3 weeks, while GFPv mice remained at pre-injection BP. Ganglion blockade reduced BP to similar levels pre- and post-transfection in GFPv and AT1Av mice. Greater pressor responses to cage-switch stress were observed following AT1AR expression (+18±2 mmHg pre- to +24±2 mmHg post-virus, P<0.05) with similar stress-induced pressor responses pre- and post-virus in GFPv mice. Pressor responses to restraint stress pre- and post-virus were similar in AT1Av but were 20% less post GFPv (P<0.001). The lack of attenuation in BP to restraint was associated with 4-fold greater Fos-expression in AT1AR mice. AT1AR expression in the NTS did not alter baroreflex gain differently between groups. The results suggest that transfection of AT1AR on neurons in the NTS elevates BP independent of the SNS and pressor responses to aversive stimuli are associated with greater Fos-expression in forebrain regions. This study suggests a novel mechanism by which the NTS may modulate MAP in the long-term via AT1AR.Cardiovascular Research 07/2013; · 5.81 Impact Factor
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ABSTRACT: Following its generation by both systemic and tissue-based renin-angiotensin systems, angiotensin II interacts with specific, G-protein coupled receptors to modulate multiple physiological systems, including the cardiovascular system. Genetic models in which the different components of the renin-angiotensin system have been deleted show large changes in resting blood pressure. Interruption of the generation of angiotensin II, or its interaction with these receptors, decreases blood pressure in hypertensive humans and experimental animal models of hypertension. Whilst the interaction of angiotensin II with the kidney is pivotal in this modulation of blood pressure, an involvement of the system in other tissues is important. Both systemic angiotensins, acting via the blood-brain barrier deficient circumventricular organs, and centrally-generated angiotensin modulate cardiovascular control by regulating fluid and electrolyte ingestion, autonomic activity and neuroendocrine function. This review discusses the pathways in the brain that are involved in this regulation of blood pressure as well as examining the sites in which altered angiotensin function might contribute to the development and maintenance of high blood pressure.Autonomic neuroscience: basic & clinical 02/2013; · 1.82 Impact Factor
Article: Angiotensin 1A receptors transfected into caudal ventrolateral medulla inhibit baroreflex gain and stress responses.[Show abstract] [Hide abstract]
ABSTRACT: The caudal ventrolateral medulla (CVLM) is important for autonomic regulation and is rich in angiotensin II type 1A receptors (AT(1A)R). To determine their function, we examined whether the expression of AT(1A)R in the CVLM of mice lacking AT(1A)R (AT(1A)(-/-)) alters baroreflex sensitivity and cardiovascular responses to stress. Bilateral microinjections into the CVLM of AT(1A)(-/-) mice of lentivirus with the phox-2 selective promoter (PRSx8) were made to express either AT(1A)R (Lv-PRSx8-AT(1A)) or green fluorescent protein (Lv-PRSx8-GFP) as a control. Radiotelemetry was used to record mean arterial pressure (MAP), heart rate (HR), and locomotor activity. Following injection of Lv-PRSx8-GFP, robust neuronal expression of GFP was observed with ∼60% of the GFP-positive cells also expressing the catecholamine-synthetic enzyme tyrosine hydroxylase. After 5 weeks, there were no differences in MAP or HR between groups, but the Lv-PRSx8-AT(1A)- injected mice showed reduced baroreflex sensitivity (-25%, P = 0.003) and attenuated pressor responses to cage-switch and restraint stress compared with the Lv-PRSx8-GFP-injected mice. Reduced MAP mid-frequency power during cage-switch stress reflected attenuated sympathetic activation (Pgroup × stress = 0.04). Fos-immunohistochemistry indicated greater activation of forebrain and hypothalamic neurons in the Lv-PRSx8-AT(1A) mice compared with the control. The expression of AT(1A)R in CVLM neurons, including A1 neurons, while having little influence on the basal blood pressure or HR, may play a tonic role in inhibiting cardiac vagal baroreflex sensitivity. However, they strongly facilitate the forebrain response to aversive stress, yet reduce the pressor response presumably through greater sympatho-inhibition. These findings outline novel and specific roles for angiotensin II in the CVLM in autonomic regulation.Cardiovascular Research 08/2012; 96(2):330-9. · 5.81 Impact Factor
Article: Disruption of muscle renin-angiotensin system in AT1a-/- mice enhances muscle function despite reducing muscle mass but compromises repair after injury.[Show abstract] [Hide abstract]
ABSTRACT: The role of the renin-angiotensin system (RAS) in vasoregulation is well established, but a localized RAS exists in multiple tissues and exerts diverse functions including autonomic control and thermogenesis. The role of the RAS in the maintenance and function of skeletal muscle is not well understood, especially the role of angiotensin peptides, which appear to contribute to muscle atrophy. We tested the hypothesis that mice lacking the angiotensin type 1A receptor (AT(1A)(-/-)) would exhibit enhanced whole body and skeletal muscle function and improved regeneration after severe injury. Despite 18- to 20-wk-old AT(1A)(-/-) mice exhibiting reduced muscle mass compared with controls (P < 0.05), the tibialis anterior (TA) muscles produced a 25% higher maximum specific (normalized) force (P < 0.05). Average fiber cross-sectional area (CSA) and fiber oxidative capacity was not different between groups, but TA muscles from AT(1A)(-/-) mice had a reduced number of muscle fibers as well as a higher proportion of type IIx/b fibers and a lower proportion of type IIa fibers (P < 0.05). Measures of whole body function (grip strength, rotarod performance, locomotor activity) were all improved in AT(1A)(-/-) mice (P < 0.05). Surprisingly, the recovery of muscle mass and fiber CSA following myotoxic injury was impaired in AT(1A)(-/-) mice, in part by impaired myoblast fusion, prolonged collagen infiltration and inflammation, and delayed expression of myogenic regulatory factors. The findings support the therapeutic potential of RAS inhibition for enhancing whole body and skeletal muscle function, but they also reveal the importance of RAS signaling in the maintenance of muscle mass and for normal fiber repair after injury.AJP Regulatory Integrative and Comparative Physiology 06/2012; 303(3):R321-31. · 3.28 Impact Factor
Article: Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure.[Show abstract] [Hide abstract]
ABSTRACT: In heart failure (HF), cardiac sympathetic nerve activity (SNA; CSNA) is increased, which has detrimental effects on the heart and promotes arrhythmias and sudden death. There is evidence that the central renin-angiotensin system plays an important role in stimulating renal SNA in HF. Because SNA to individual organs is differentially controlled, we have investigated whether central angiotensin receptor blockade decreases CSNA in HF. We simultaneously recorded CSNA and renal SNA in conscious normal sheep and in sheep with HF induced by rapid ventricular pacing (ejection fraction: <40%). The effect of blockade of central angiotensin type 1 receptors by intracerebroventricular infusion of losartan (1 mg/h for 5 hours) on resting levels and baroreflex control of CSNA and renal SNA were determined. In addition, the levels of angiotensin receptors in central autonomic nuclei were determined using autoradiography. Sheep in HF had a large increase in CSNA (43±2 to 88±3 bursts per 100 heart beats; P<0.05) and heart rate, with no effect on renal SNA. In HF, central infusion of losartan for 5 hours significantly reduced the baseline levels of CSNA (to 69±5 bursts per 100 heart beats) and heart rate. Losartan had no effect in normal animals. In HF, angiotensin receptor levels were increased in the paraventricular nucleus and supraoptic nucleus but reduced in the area postrema and nucleus tractus solitarius. In summary, infusion of losartan reduced the elevated levels of CNSA in an ovine model of HF, indicating that central angiotensin receptors play a critical role in stimulating the increased sympathetic activity to the heart.Hypertension 03/2012; 59(3):634-41. · 6.87 Impact Factor
Article: Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress.[Show abstract] [Hide abstract]
ABSTRACT: The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A receptors (AT(1A)Rs) at various sites within the brain, including the rostral ventrolateral medulla. In this study we examine the involvement of AT(1A)Rs associated with a subclass of sympathetic premotor neurons of the rostral ventrolateral medulla, the C1 neurons. The distribution of putative AT(1A)R-expressing cells was mapped throughout the brains of three transgenic mice with a bacterial artificial chromosome-expressing green fluorescent protein under the control of the AT(1A)R promoter. The overall distribution correlated with that of the AT(1A)Rs mapped by other methods and demonstrated that the majority of C1 neurons express the AT(1A)R. Cre-recombinase expression in C1 neurons of AT(1A)R-floxed mice enabled demonstration that the pressor response to microinjection of angiotensin II into the rostral ventrolateral medulla is dependent upon expression of the AT(1A)R in these neurons. Lentiviral-induced expression of wild-type AT(1A)Rs in C1 neurons of global AT(1A)R knock-out mice, implanted with radiotelemeter devices for recording blood pressure, modulated the pressor response to aversive stress. During prolonged cage-switch stress, expression of AT(1A)Rs in C1 neurons induced a greater sustained pressor response when compared to the control viral-injected group (22 ± 4 mmHg for AT(1A)R vs 10 ± 1 mmHg for GFP; p < 0.001), which was restored toward that of the wild-type group (28 ± 2 mmHg). This study demonstrates that AT(1A)R expression by C1 neurons is essential for the pressor response to angiotensin II and that this pathway plays an important role in the pressor response to aversive stress.Journal of Neuroscience 02/2012; 32(6):2051-61. · 6.91 Impact Factor
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ABSTRACT: C3 neurons constitute one of three known adrenergic nuclei in the rat central nervous system (CNS). While the adrenergic C1 cell group has been extensively characterized both physiologically and anatomically, the C3 nucleus has remained relatively obscure. This study employed a lentiviral tracing technique that expresses green fluorescent protein behind a promoter selective to noradrenergic and adrenergic neurons. Microinjection of this virus into the C3 nucleus enabled the selective tracing of C3 efferents throughout the rat CNS, thus revealing the anatomical framework of C3 projections. C3 terminal fields were observed in over 40 different CNS nuclei, spanning all levels of the spinal cord, as well as various medullary, mesencephalic, hypothalamic, thalamic, and telencephalic nuclei. The highest densities of C3 axon varicosities were observed in Lamina X and the intermediolateral cell column of the thoracic spinal cord, as well as the dorsomedial medulla (both commissural and medial nuclei of the solitary tract, area postrema, and the dorsal motor nucleus of the vagus), ventrolateral periaqueductal gray, dorsal parabrachial nucleus, periventricular and rhomboid nuclei of the thalamus, and paraventricular and periventricular nuclei of the hypothalamus. In addition, moderate and sparse projections were observed in many catecholaminergic and serotonergic nuclei, as well as the area anterior and ventral to the third ventricle, Lamina X of the cervical, lumbar, and sacral spinal cord, and various hypothalamic and telencephalic nuclei. The anatomical map of C3 projections detailed in this survey hopes to lay the first steps toward developing a functional framework for this nucleus.The Journal of Comparative Neurology 01/2012; 520(11):2352-68. · 3.66 Impact Factor
Article: Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension.[Show abstract] [Hide abstract]
ABSTRACT: Dietary deficiency of ω-3 fatty acids (ω-3 DEF) produces hypertension in later life. This study examined the effect of ω-3 DEF on blood pressure and hypothalamic gene expression in young rats, before the development of hypertension, and in older rats following the onset of hypertension. Animals were fed experimental diets that were deficient in ω-3 fatty acids, sufficient in short-chain ω-3 fatty acids or sufficient in short- and long-chain ω-3 fatty acids, from the prenatal period until 10 or 36 weeks-of-age. There was no difference in blood pressure between groups at 10 weeks-of-age; however, at 36 weeks-of-age ω-3 DEF animals were hypertensive in relation to sufficient groups. At 10 weeks, expression of angiotensin-II(1A) receptors and dopamine D(3) receptors were significantly increased in the hypothalamic tissue of ω-3 DEF animals. In contrast, at 36 weeks, α(2a) and β(1) adrenergic receptor expression was significantly reduced in the ω-3 DEF group. Brain docosahexaenoic acid was significantly lower in ω-3 DEF group compared with sufficient groups. This study demonstrates that dietary ω-3 DEF causes changes both in the expression of key genes involved in central blood pressure regulation and in blood pressure. The data may indicate that hypertension resulting from ω-3 DEF is mediated by the central adrenergic system.Hypertension Research 11/2011; 35(4):381-7. · 2.79 Impact Factor
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ABSTRACT: Astrocytes are the major source of angiotensinogen in the brain and play an important role in the brain renin-angiotensin system. Regulating brain angiotensinogen production alters blood pressure and fluid and electrolyte homeostasis. In turn, several physiological and pathological manipulations alter expression of angiotensinogen in brain. Surprisingly, little is known about the factors that regulate astrocytic expression of angiotensinogen. There is evidence that angiotensinogen production in both hepatocytes and cardiac myocytes can be positively regulated via the angiotensin type 1 receptor, but this effect has not yet been studied in astrocytes. Therefore, the aim of this project was to establish whether angiotensin II modulates angiotensinogen production in brain astrocytes. Primary astrocyte cultures, prepared from neonatal C57Bl6 mice, expressed angiotensinogen measured by immunocytochemistry and real-time PCR. Using a variety of approaches we were unable to identify angiotensin receptors on cultured astrocytes. Exposure of cultured astrocytes to angiotensin II also did not affect angiotensinogen expression. When astrocyte cultures were transduced with the angiotensin type 1A receptor, using adenoviral vectors, angiotensin II induced a robust down-regulation (91.4% ± 1.8%, p < 0.01, n = 4) of angiotensinogen gene expression. We conclude that receptors for angiotensin II are present in extremely low levels in astrocytes, and that this concurs with available data in vivo. The signaling pathways activated by the angiotensin type 1A receptor are negatively coupled to angiotensinogen expression and represent a powerful pathway for decreasing expression of this protein, potentially via signaling pathways coupled to Gα(q/11) .Journal of Neurochemistry 07/2011; 119(1):18-26. · 3.97 Impact Factor
Article: Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata.[Show abstract] [Hide abstract]
ABSTRACT: Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses. In anaesthetized rats in vivo and perfused rat working heart brainstem preparations in situ, C1 neurones were acutely silenced by application of the insect peptide allatostatin following cell-specific targeting with a lentiviral vector to express the inhibitory Drosophila allatostatin receptor. In anaesthetized rats with denervated peripheral chemoreceptors, acute inhibition of 50% of the C1 neuronal population resulted in ∼50% reduction in renal sympathetic nerve activity and a profound fall in arterial blood pressure (by ∼25 mmHg). However, under these conditions systemic hypercapnia still evoked vigorous sympathetic activation and the slopes of the CO(2)-evoked sympathoexcitatory and cardiovascular responses were not affected by inhibition of C1 neurones. Inhibition of C1 neurones in situ resulted in a reversible fall in perfusion pressure and the amplitude of respiratory-related bursts of thoracic sympathetic nerve activity. These data confirm a fundamental physiological role of medullary catecholaminergic C1 neurones in maintaining resting sympathetic vasomotor tone and arterial blood pressure. However, C1 neurones do not appear to mediate sympathoexcitation evoked by central actions of CO(2).Cardiovascular Research 05/2011; 91(4):703-10. · 5.81 Impact Factor
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ABSTRACT: Hypertension affects more than 1.5 billion people worldwide but the precise cause of elevated blood pressure (BP) cannot be determined in most affected individuals. Nonetheless, blockade of the renin-angiotensin system (RAS) lowers BP in the majority of patients with hypertension. Despite its apparent role in hypertension pathogenesis, the key cellular targets of the RAS that control BP have not been clearly identified. Here we demonstrate that RAS actions in the epithelium of the proximal tubule have a critical and nonredundant role in determining the level of BP. Abrogation of AT(1) angiotensin receptor signaling in the proximal tubule alone is sufficient to lower BP, despite intact vascular responses. Elimination of this pathway reduces proximal fluid reabsorption and alters expression of key sodium transporters, modifying pressure-natriuresis and providing substantial protection against hypertension. Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension.Cell metabolism 04/2011; 13(4):469-75. · 17.35 Impact Factor
Article: Angiotensin type 1A receptors transfected into the A1 neurons inhibit baroreflex gain and the cardiovascular response to stress in AT 1A −/− miceAutonomic Neuroscience-basic & Clinical - AUTON NEUROSCI-BASIC CLIN. 01/2011; 163(1):53-53.
Article: Role of angiotensin in the rostral ventrolateral medulla in the development and maintenance of hypertension.[Show abstract] [Hide abstract]
ABSTRACT: Whilst crucial for behavioural and homeostatic responses to environmental challenges, chronic elevation of sympathetic nervous system activity to specific vascular beds is associated with hypertension. Indeed such elevated activity may drive the increase in blood pressure seen in some people and in some experimental models of hypertension. This review discusses the neural circuitry involved in generating and modulating sympathetic efferent nerve activity, focusing on the premotor neurons of the rostral ventrolateral medulla. Neurons in the rostral ventrolateral medulla show altered responses to angiotensin II in experimental models of hypertension, suggesting that this might be an important node for interaction between these two systems that are crucial for regulation of blood pressure.Current Opinion in Pharmacology 01/2011; 11(2):117-23. · 5.44 Impact Factor
Article: Is augmented central respiratory-sympathetic coupling involved in the generation of hypertension?[Show abstract] [Hide abstract]
ABSTRACT: Respiratory modulation of autonomic neural activity, with consequent phasic alteration of cardiac and vascular function, has been observed in many species including humans and is considered an index of cardiovascular health. Whilst many factors contribute to this modulation, including for example baroreceptor reflex feedback, it is accepted that a significant component is derived from an interaction within the central nervous system. Functional links between the brainstem circuitry generating the respiratory rhythm and neurons responsible for generate sympathetic and parasympathetic activity to the cardiovascular system have long been hypothesized, although the detailed understanding of these interactions is incomplete. There are several proposed physiological functions for these interactions including the matching of ventilation to cardiac output and tissue blood flow. However, recent observations suggest that altered central respiratory coupling may play a role in the development of hypertension and in the maintenance of elevated levels of sympathetic vasomotor activity in disease. The focus of this review article is to discuss these observations and place them within the context of current understanding of the neural substrates that might be responsible for respiratory-sympathetic coupling.Respiratory Physiology & Neurobiology 11/2010; 174(1-2):89-97. · 2.05 Impact Factor
Top Journals
University of Melbourne
Melbourne, Victoria, Australia
- • Department of Physiology
- • Department of Medicine
Monash University (Australia)
Melbourne, Victoria, Australia
- Department of Physiology
Victoria University MelbourneMelbourne, Victoria, Australia
Austin HealthMelbourne, Victoria, Australia
Universität HeidelbergHeidelburg, Baden-Württemberg, Germany
The Royal Children's HospitalMelbourne, Victoria, Australia


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Fort Pierce, United States of America
1985 Reynolds Drive, Fort Pierce, FL 34945, United States of America – Show map
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Outdoor Pool, Outdoor Pool (all year)
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Free public parking is available on site (reservation is not needed).
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Any additional older children or adults stay free of charge when using existing beds.
One older child or adult is charged USD 10 per person per night in an extra bed.
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The maximum number of extra beds/cribs in a room is 1.
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La Quinta Inn & Suites Fort PierceLocated between Interstate-95 and the Florida Turnpike, this Fort Pierce hotel is 5 miles from PGA Golf Club. It features an outdoor pool and spacious rooms with a 37-inch flat-screen TV.
Score from 61 reviews Very good
Located between Interstate-95 and the Florida Turnpike, this hotel is a 10-minute drive from both downtown Fort Pierce and PGA Golf Club. It is also less than 10 miles from Tradition Field.
Score from 75 reviews Very good
Royal Inn Beach Hutchinson IslandThis Hutchinson Island boutique hotel is a 3 minute walk from sandy beaches and the Inlet Jetty Boardwalk.
Score from 72 reviews Good
Fairfield Inn & Suites Fort PierceThis Fairfield Inn is located just off I-95, 5 miles from 21 Mile Beach. The hotel has an outdoor pool and a whirlpool, and provides free Wi-Fi throughout the hotel.
Score from 70 reviews Excellent
Room was clean & had a refrigerator & microwave. We appreciated the 24 hour coffee center.
We had requested a quiet room & the room we were given was located just off the elevator & near the ice machine & vending machine. There was a travel baseball tournament taking place in the area, so our room was not very quiet.
Roomy room.
Breakfast was lacking .
Clean and comfortable
Good breakfast, and clean room
The omellettes for breakfast were a nice change.
The fact that the swiming pool was an outside pool.
All Good
Nice room and nice people
Great breakfast. Also, when we checked in, the gal at the front desk promptly helped us with a restaurant recommendation, and gave us mapguest directions.
Could have used a larger breakfast space, as there was a really large group there for breakfast.
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Telomeres are sections of DNA that tell an interesting story about lifespan. Shorter telomeres usually suggest a shorter life -- but new research by a Wilmot lung cancer expert shows that longer telomeres might be a promising biomarker for a recurrence of early stage lung cancer.
A whopping 76 posters, representing the research of graduate students and post-docs in the Center for Musculoskeletal Research (CMSR), filled the Flaum Atrium on September 18 as part of the Third Annual CMSR Scientific Symposium. The day-long event also featured oral presentations by graduate students, post-docs, and faculty on a wide range of research related to the biology and pathology of muscle, cartilage and bone.
The answer is yes, according to a new study out today in the Milbank Quarterly. In fact, where older adults rank in the "big five" personality traits correlates to how frequently they use a range of additional expensive health services such as hospital stays, hospital-based rehabilitation, and skilled nursing home care.
We all know that traveling to different time zones or working the night shift shakes up our body clocks. A new URMC study also shows that tobacco smoke can harm circadian rhythms, by changing gene expression patterns in lung tissue.
Although many childhood leukemias are curable, one type – known as 11q23 infant leukemia – has a poor survival rate and requires intensive treatment with life-threatening side effects. In an early-edition article in Blood, the URMC shows it discovered a gene that could provide a new target for therapy.
If you're being treated for cancer and experiencing symptoms, what would cause you to pick up the phone and call your cancer center? Pain emerged as the number one reason, in a study of 563 patients, who reported 2,378 symptoms during 1,229 phone calls to the James P. Wilmot Cancer Center.


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LBO France and Maple Knoll Capital buy French office assets
Related fund data links
LBO France and Maple Knoll Capital have acquired assets in a recently closed portfolio transaction concerning four office buildings in the outskirts of Paris.
The portfolio includes a 17,000 sq m environmentally certified office building in St Ouen let to Alstom Transports with a 12-year firm lease, as well as three additional office assets.
Phillip Burns, CEO of Maple Knoll Capital, says: "This is our first deal in France and follows our recent acquisition of a 60,000 sq m office building in Munich, Germany. Maple Knoll is focused on value-add and opportunistic real estate and we continue to see selective opportunities in Europe."
Stéphanie Casciola, head of real estate at LBO France, says: "This is our third acquisition since the start of the year, following that of the 24 light-industrial asset LIPS portfolio in Ile-de-France and a 10,000 sq m office building located in the French CBD La Défense (Le Cap). These acquisitions illustrate our ambition to be increasingly active in the context of a recovering French market, which particularly lends itself to value added investment strategies.
The investment department of Catella brokered the transaction representing over 60,000 sq m. Natixis provided financing to both LBO France and Maple Knoll Capital.
LBO France and Maple Knoll Capital were advised by Clifford Chance (Francois Bonteil, Adeline de Menonville), Wragge & Co (Pierre Appremont, Pierre-Emmanuel Chevalier) and by Etude Monassier (Sylvie Burthe-Mique, Guillaume Palais).
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The Hanlan Water Project is the largest and most extensive water infrastructure project that the Region of Peel has undertaken. Major streets affected by construction include Lakeshore Road East, Dixie Road, Eastgate Parkway, Tomken Road and Cawthra Road.
Read more about Hanlan and your commute here.
For details on the Hanlan Water Project, visit www.hanlanwaterproject.ca
Lane restrictions on Bloor Street from Golden Orchard Drive to Havenwood Drive.*
June 9, 2014
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September 23, 2014
Lane restrictions on Dixie Road south of Winding Trail to Golden Orchard Drive.*
Lane restrictions on Dixie Road from south of Hickory Drive to Burnhamthorpe Road.*
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Lane restrictions on Dixie Road from the Queensway to North Service Road.*
*Effective Sept. 2, 2013 additional buses have been allocated to address potential service delays.
Please be advised that weather conditions and road construction can affect the timely arrival of your bus and you may experience delays on some of our routes. Please give yourself extra time when planning your trip.
We have various ways to help you plan your trip and get the latest schedule times:


text: We decided to take this scenic drive instead of the highway so we could just stroll along and enjoy the scenery. I can say it didn't disappoint! We stopped along the river where we took beautiful pictures and enjoyed our time in nature. It was pleasant and gave our young girls a great experience.


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MONDAY, Sept. 17 (HealthDay News) -- Smoking-induced insulin resistance, which improves with smoking cessation, may be due to activation of mammalian target of rapamycin (mTOR), according to a study published online Sept. 10 in Diabetes.
To investigate the mechanism of smoking-induced insulin resistance, Bryan C. Bergman, Ph.D., from the University of Colorado Denver, and colleagues studied insulin sensitivity in 12 healthy sedentary nonsmokers and 10 smokers.
The researchers found that the smokers were less sensitive to insulin, but sensitivity improved after they stopped smoking for one or two weeks. The improvement was associated with normalized phosphorylation of insulin receptor substrate-1 (IRS-1) at serine 636. Treatment of muscle cells with nicotine reduced insulin sensitivity and was associated with increased phosphorylation of IRS-1 at serine 636. One of the two possible pathways known to stimulate IRS-1 phosphorylation, mTOR, was stimulated by nicotine; mTOR also prevented IRS-1 phosphorylation during nicotine exposure and normalized insulin sensitivity when inhibited.
"These data indicate nicotine induces insulin resistance in skeletal muscle by activating mTOR," Bergman and colleagues conclude. "Therapeutic agents designed to oppose skeletal muscle mTOR activation may prove a novel strategy for individuals who are at increased risk of diabetes and cardiovascular disease because they cannot stop smoking or are exposed to secondhand smoke."
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When is the Peace Ball?
January 20, the evening before the Presidential Inauguration
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Each $200 ticket includes admission for one to The Peace Ball, VIP reception, refreshments and open bar.
- VIP Reception begins at 6:00pm
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Show for Nov 25, 2014
Ferguson Erupts After Grand Jury Decides Not to Indict Darren Wilson
Secretary of Defense Chuck Hagel Forced to Resign
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Iran Nuclear Talks Extended for 7 Months
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Obama Awards Medal of Freedom to 18, Including 3 Slain Civil Rights Activists
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Hijack mission for DRIV3RHome / PC - Windows /
This page contains DRIV3R Hints for PC - Windows called "Hijack mission" and has been posted or updated on Feb 2, 2009 by rochelle. Let us know what you think of this Hint by thumbs voting.
- Developer: Reflections Interactive
- Publisher: Atari
- Genre: Driving Mission-based
- Release Date: Mar 15, 2005
- ESRB: Mature
Hijack mission
Move the truck in the road. Follow the truck until you are blocked in. Shoot off the front bumper with the M-16 then continue to shoot it towards the vehicle. As it bounces off of the truck, the truck will get back out of the way. By doing this, you do not have to go off the annoying jump around back of the building that always flips your car over. When you catch up to the truck, get alongside him and just push the front of the it toward the lamp posts. He will immediately come to a violent stop. This will give you a perfect opportunity to kill him without totaling his vehicle, and thereby ruining the mission. To find the place where the car is located, continue on the path he was taking then take a left to get to the end of the map and make a right. You will see a couple of gunman on the right in front of the entrance. Never go in the other side, placing the target in the line of fire.
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November 27, 2014
Stay up-to-date with KAKE News:
Thursday, September 23, 2010
The nation's only four-year degree program in automotive restoration is right here in Kansas. Now, the program is expanding to include a major in motorcycles.
Students at McPherson College's Automotive Restoration Program learn techniques for auto restoration like removing dents, shaping metal, and welding. The auto restoration program gives students the chance to build their skills and then gain practical experience by restoring vehicles as part of the classroom curriculum.
The students work on cars from the early 1900s to the muscle car era. Now, students can also earn a degree in motorcycle restoration. The first students in the program will begin work this semester learning about the history of motorcycles. Next semester, they will begin work on restoring donated bikes.
Program administrators say there is a demand for people who restore and repair motorcycles. The program will kick off with a rally on the McPherson College campus in McPherson on Saturday, September 25th.
The rally is free to the public and includes free barbecue, tours of the auto restoration labs, and a chance to see McPherson students build a Model-T from a pile of parts in less than 20 minutes. For more information check out the McPherson College website by clicking on "Related Links" below.
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Narrow your search
We've limited the list to standalone streaming boxes.
Roku's Streaming Stick offers tons of apps, a real remote, and a compact design for just $50, making it the best streaming stick and an outstanding value.
The Stream is a budget "cloud-based PC," now available in two new laptop and two new tablet sizes, making it one of the least expensive ways to get Windows 8.
The video giant already attracts a billion unique visitors monthly, but will those users pay to play? YouTube gave CNET an exclusive demo of streaming service Music Key.
The Stream is a budget "cloud-based PC," available in five sizes, and one of the least-expensive ways to get Windows 8 in a laptop or tablet.
Let's crowd-source an answer to this important question, with a special eye toward families with multiple users.
If you keep expectations in check, this bargain-basement Windows 8 laptop has good battery life and a decent design.
In a bold statement about security, a new site is broadcasting live feeds from thousands of web cameras, some of which show home interiors. CNET's Sumi Das talks to CNET's Ian Sherr about who's at fault and how you can protect yourself.
The fitness-tracking Basis Peak gets new accessories and some deeper connectivity -- with call notifications coming soon.
The Samsung Wireless is the best mobile device for media streaming and data backup, but only Android users need apply.
Streaming boxes, sticks, Blu-ray players and, well, other stuff. All offer video streaming from Netflix and other sources, often for affordable prices that make them ideal holiday gifts. Here are our favorites for 2014.


text:
Chat dr sharad upadhye rashi bhavishya(mi marathi , Internet and technology answers. maja naav hema aahe maji janma vela sakali 4 chi aahe maji janma tarikha 3/2/1988 aahe mala maja bhavisha kay aahe te saag. Marathi horoscope 2013 - marathi astrology 2013 | rashi, Providing yearly prediction of all the zodiac sign in marathi language, rashi by rashi, yearly zodiac prediction by marathi astrology 2013. for those who prefer to. Rashi bhavishya 2013 | marathi horoscope 2013 | marathi, Get rashi bhavishya 2013 in marathi. most accurate marathi horoscope 2013, rashi bhavishya 2013, and marathi astrology 2013 by astrosage.com.
My Rashi Bhavishya 2013 In Marathi


text:
Metformin in Obese Non-diabetic Pregnant Women (MOP)
The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by Epsom and St Helier University Hospitals NHS Trust.
Recruitment status was Recruiting
Recruitment status was Recruiting
Epsom and St Helier University Hospitals NHS Trust
Fetal Medicine Foundation
King's College Hospital NHS Trust
Information provided by (Responsible Party):
Epsom and St Helier University Hospitals NHS Trust
ClinicalTrials.gov Identifier:
First received: January 7, 2011
Last updated: January 31, 2012
Last verified: January 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is currently recruiting participants.
|Estimated Study Completion Date:
|September 2014
|Estimated Primary Completion Date:
|June 2014 (Final data collection date for primary outcome measure)


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Junior Member
hello i am looking to join a good group of ppl that just want to play Lol and have fun. i am new to the game and am still learning but i really enjoy playing. looking for a group to take me under their wing and help me learn the game better and not rage it i die lots or dont understand the game terminology lol. looking forward to any replies.
SOTS HyperLust
Senior Member
Hello Fushyn. Nice name btw! Would you be interested in Team Air Gear? Our head leaders are willing to help. This is what we are here for. Not only are we interested in playing ranked games, raising our ELO and meeting new people, we also have special groups for people that are below level 30 to help them level up and help with anything that is requested! So please contact us and fill out the contact form on our site below. Someone will email you back today! I hope you consider! Thank you!
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


text:
November 10 -11, 2012 Time: Saturday ~ 9:00 am – 5:00 pm Time: Sunday ~ 12:00 noon – 5:00 pm Location: Killeen Civic & Conference Center Contact: Lori Brooks 254-833-2656 Description: Annual holiday bazaar featuring a variety of arts and crafts vendors.
The Friends of the Killeen City Library System will hold their annual used book sale at the Killeen Community Center (corner Veteran's Memorial Blvd and W.S. Young Drive) on Saturday, November 10, 2012. ...
City of Killeen offices will be closed November 27 and 28 in observance of Thanksgiving. All city offices will reopen December 1. ... Read More
Killeen will mark the start of the holiday season November 29 with the annual Tree Lighting event at the Killeen Community Center, 2201 East Veterans Memorial Boulevard. The public is invited to join in an evening of free family fun. ... Read More
The Friends of the Central Texas State Veterans Cemetery will lay more than 5,000 wreaths at the Central Texas State Veterans Cemetery Saturday, November 29, at 10 a.m. The public is encouraged to participate. ... Read More
The City of Killeen will host Holiday Extravaganza December 13 from noon to 5 p.m. at Green Avenue Park, 717 N. 2nd Street. ... Read More
Killeen residents are invited to show off their festively decorated homes in the annual outdoor holiday decorating contest. ... Read More
HEB and the City of Killeen will host the seventh annual Feast of Sharing December 16 from 4 to 8 p.m. at the Killeen Civic and Conference Center. ... Read More


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Dodge NASCAR
Manufacturer wars: Chevy is king but history shows wealth shared
victorious in seven different brands in NASCAR : Chevrolet, Ford, Dodge , Plymouth, Pontiac, Oldsmobile ..... Keselowski drove a Team Penske Dodge to the Sprint Cup championship. Before Dodge pulled out of NASCAR , the automaker's biggest season
Longtime motorsports PR professional Denny Darnell dead
sponsor of what then was the NASCAR Winston Cup Series. It was in the early 1990s that NASCAR exploded from a regional ..... relations representative for Dodge when the automaker finished ..... admired and respected in the NASCAR community for the quality
Highlights of the 2014 SEMA Show ... so far | FOX Sports
twitter.com/GHc4drzs9X — Dodge (@ Dodge ) November 5, 2014 Motorsports ..... DavidWilsonTRD) November 5, 2013 Motorsports Dodge Ram 3500. #SEMA #SEMA2014 pic ..... Motorsports More #SEMA2014 at the # NASCAR booth - @KyleBusch 's 2015 @JoeGibbsRacing
Last Lap: Could Dodge Be Returning To NASCAR ?
Updated NOV 22, 2013 3:51a ET NASCAR Is it true? Could Dodge be returning to NASCAR ? Reportedly, Chrysler is talking ..... Last Lap for Monday, April 22nd. - Dodge may be headed back to NASCAR [Beyond The Flag] - SPEED Exclusive
Dodge Challenger SRT Hellcat price, speed revealed | SPEED | The Motors On FOX Blog
SUPERCROSS SPORTS CARS NASCAR CARS VIDEO TV SCHEDULE Search for: Jul 17 Dodge Challenger SRT Hellcat ..... 8-speed automatic. Dodge President and CEO Tim ..... mph. Cars Challenger Dodge Post navigation ← F1 ..... Motocross TUDOR Series NASCAR Race Results F1 Interactive
707-Horsepower Dodge Challenger SRT Is The Most Powerful American Car Ever | SPEED | The Motors On FOX Blog
1 INDYCAR SUPERCROSS SPORTS CARS NASCAR CARS VIDEO TV SCHEDULE Search for: Jul 4 707-Horsepower Dodge Challenger SRT Is The Most Powerful ..... News at 12:42 pm Cars Challenger Dodge The 2015 Dodge Challenger SRT packs 707 horsepower
Spencer: Dodge's legacy
last few weeks we've been speculating whether or not was in a race in NASCAR . On Tuesday he made it clear that they were going to poll out at the end ..... plug on the program. And for a lot of race fans it's a sad sad day for NASCAR .we've been speculating whether or not -- was in a race in NASCAR . On Tuesday he made it clear that they were going to poll out at the end of 2012. And until the foreseeablefor a lot of race fans it's a sad sad day for NASCAR .
TUDOR Championship: Dodge Viper Big Fire - 12 Hours of Sebring 2014
United SportsCar Championship: #33 Ben Keating in the Dodge Viper GT-D Class car catches fire in turn 6 at Gurney Bend.
Coupal OK after dramatic flip in NASCAR Canadian Tire Series race (VIDEO)
Sunday's NASCAR Sprint Cup and TUDOR Championship races at Watkins Glen ..... walk away. Likewise was the fortune for Xavier Coupal, a NASCAR Canadian Tire series driver whose Dodge Challenger tore itself apart in the closing laps of Sunday's
NASCAR and Elvis: Just A Hunk, A Hunk Of Burnin' Love
Updated NOV 22, 2013 4:05a ET NASCAR Today we celebrate the life of The ..... Without question, Elvis was a NASCAR man. The King starred in a bunch ..... Speedway," where he drove a Dodge Charger built by NASCAR Hall of Fame member Cotton Owens


text:
Sell Your Shoretel-Avaya-Mitel-Cisco Phones- Telephone Systems-Fast Bids! New/Used Phones-Systems- Email to email@example.com
The Trusted Telecom Source for Mitel-Shoretel-Avaya-Nortel and more!The customer service leader in Business Telecom Industry since 1998- Buy-Sell-Support Phone Systems
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Have Telecom Items For Sale? Top Dollar Offered - Lightning Fast Bids Provided firstname.lastname@example.com


text:
East Huntingdon man shoots self in hand with pistol
An East Huntingdon man accidentally shot himself in the hand early Monday, according to state police.
Jeremy Clark Sultzer, 24, was in a bedroom of a Homestead Avenue home playing video games at 1:45 a.m. when he took out a recently purchased Sig Sauer .9mm pistol and loaded it, police said.
Sultzer was placing the gun back in its holster and attempting to lower the hammer when his finger slipped, causing the weapon to discharge, police said. The bullet went through Sultzer's left hand, breaking several bones, police said.
He was treated at Excela Health Frick Hospital and later taken to UPMC Presbyterian in Pittsburgh, where he was in fair condition Tuesday afternoon.
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text:
Early election results show Northwest Georgia voters rejected the controversial transportation sales tax referendum by a large majority.
With 10 of 15 counties reporting totals, the sales tax was voted down by 67.5 percent in the 15-county district in Northwest Georgia. Across the state most districts appeared to be rejecting the sales tax increase.
The transportation special purpose local option sales tax was designed to allow voters in each district to decide if they wanted their sales tax increased by one percent.
But criticism across the state questioned whether the sales tax would hurt the economy in the long run and if larger counties would lose money for the smaller counties within the district.
The 18-billion project would last for 10 years.
Joy Lukachick Smith is the city government reporter for the Chattanooga Times Free Press. Since 2009, she's covered crime and court systems in North Georgia and rural Tennessee, landed an exclusive in-prison interview with a former cop convicted of killing his wife, exposed impropriety in an FBI-led, child-sex online sting and exposed corruption in government agencies. Earlier this year, Smith won the Malcolm Law Memorial Award for Investigative Reporting. She also won first place in ...


text:
Arizona State Sun Devils
ASU Associate AD Rocky Harris: 'Haven't seen this kind of excitement since 1996'
Tempe is more abuzz than it's been since Arizona State senior associate athletic director, Rocky Harris, was a student.
Second-year coach Todd Graham has the Sun Devils prepared to play host to Stanford in the third Pac-12 Championship Game and the first in program history. And with a trip to the Rose Bowl on the line, the anticipation has incited memories of the team's last trip to Pasadena, in 1996, when Harris was merely an undergrad.
"I haven't seen this type of excitement since then and even maybe that year," Harris told The Dan Bickley Show with Vince Marotta on Thursday.
Although the game is produced by the conference, Harris is thrilled with the privilege to host it, sharing that he believed it would be a sellout. Because production is out of ASU's hands, there will be no pre-game fireworks or pro-Sun Devil videos on the docket.
"It is a somewhat neutral game," Harris explained. "I wouldn't call it neutral, though, with 68,000 ASU fans and 2,500 Stanford fans, that's not very neutral.
"But they're trying to make it so it's as fair as possible for the opposing team."
What's more? Stanford has had so much trouble selling their portion of tickets that they sent back a share to Arizona State yesterday, according to Harris.
"Stanford returned about a quarter of theirs which, to me, I'd rather have a quarter empty seats than a quarter in red or cardinal cheering on their team," he told the show.
Kickoff is scheduled for 5:45 p.m. Saturday at Sun Devil Stadium.
Remaining tickets can be purchased online, by calling (480) 965-5333 or at the Sun Devil Stadium box office.
Most Popular
Sun Devils Audio
- Vince Marotta's Territorial Cup PoemVince revisits his tradition of writing a poem regarding the Duel in the Desert.
- Ray Anderson- ASU athletic directorHe may be new to the rivalry, but Ray Anderson is starting to see the importance of the Territorial
- Bickley BlastUCLA's chances for a national championship may be slim, but their hopes are still alive.
- Jeff Van Raaphorst-Former ASU quarterback Jeff Van Raaphorst believes that rivalry games affect fans more than they do players.
- Mark May, ESPN college football analyst ESPN college football analyst Mark May says this is the biggest Territorial Cup game he can remember


text:
Just two of the six coaches in this week's finals have won state championships: Dixie's Blaine Monkres at Morgan in 1993 and Mountain Crest's Mark Wootton in 2005.
The other four make their first title game appearances and, of course, Spanish Fork's Kirk Chambers and Timpview's Cary Wittingham are first-year coaches.
Those two become the 39th and 40th coaches to advance to the title game their inaugural season and the first since Highland's Brody Benson in 2006. The last coach to win a state championship his first year was Monticello's Seth Giddings in 2004. Of the previous 38 to make the finals, 18 celebrated victories.
Spanish Fork and Syracuse emerge on the championship stage for the first time, while Jordan and Dixie haven't been there since 1998. Mountain Crest is back for the second time in three seasons, and after missing the last two, Timpview returns for the fifth time in seven years and the sixth time in nine seasons.
5A Championship – Jordan (11-1) vs. Syracuse (12-0)
Series history: First meeting
Coach vs. coach: First meeting between Jordan's Eric Kjar and Syracuse's Russ Jones.
Current winning streaks: Jordan 6 (but 11 against Utah schools), Syracuse 12 (school record).
Jordan Quick Facts
Began its gridiron program in 1909, 103rd season. Finals record: 11-4 (.733). Last championship: 1994. Playoff record: 50-30 (.625), 42nd appearance.
Championship game history:
1931, beat Logan 18-0
1934, beat Box Elder 3-0
1936, beat Box Elder 13-7
1938, lost to Carbon 6-0 (A)
1939, beat North Cache 13-0 (A)
1940, beat Carbon 7-6 (A)
1941, beat Box Elder 20-12 (A)
1944, beat Provo 7-0 (A)
1947, beat Logan 21-6 (A)
1948, beat Carbon 28-0 (A)
1950, beat Box Elder 13-0 (A)
1981, lost to Judge Memorial 52-13 (3A)
1983, lost to Judge Memorial 26-21 (3A)
1994, beat Bear River 27-7 (4A)
1998, lost to Skyline 41-21 (5A)
Coach: Erik Kjar is 37-13 (.740) in his fourth season, since 2009. Kjar took the Beetdiggers from 7-5 and the quarterfinals his first year to 9-4 in 2010 and 10-3 last season and back-to-back semifinals.
Playoff record: 7-3, fourth appearance and first championship game.
Syracuse Quick Facts
Opened in 2007, sixth season. First championship contest. Playoff record: 8-4 (.667), fifth appearance.
Coach: Russ Jones is 45-23 (.662) in his sixth season at Syracuse, since 2007. Overall, he's 70-50 (.583) in his 11th season, including 20-13 in three years at Viewmont (2000-02) and 5-14 in two seasons at Woods Cross (2005-06).
Jones guided the Titans from 0-10 their first season to 10-3 and the semifinals their second year.
Playoff record at Syracuse: 8-4 (.667), fifth appearance. Overall: 10-7 (.588), eighth appearance, including 2-2 at Viewmont and 0-1 at Woods Cross. First championship game.
Extra Point 1: Last week, Jordan continued its pattern of scoring at least five touchdowns in every game this season.
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For the creators of the faith-based baseball drama "Home Run," making a movie that was real meant more than ensuring their lead actor looked right swinging a bat and running the bases.
Faith-based drama 'Home Run' seeks honest approach to addiction, recovery
"It's in the faith genre but it's a true life story," Tulsa-based producer Carol Spann Mathews said.
"It's about not only addiction and recoveries, but it's about past hurt and how that passes down from generation to generation. It's about fathers and sons; it's about single parents. When people watch the film, we hear over and over again that they relate to a character, and it's different for everybody."
The movie, filmed in Okmulgee and Tulsa in 2011, opened in theaters nationwide Friday.
Addressing addiction
Mathews, an award-winning television and film producer whose work has been featured on Trinity Broadcast Network, The Family Channel and ESPN, co-produced and worked as executive producer on "Home Run" with fellow Tulsan Tom Newman, whose credits include the Max Lucado adaptations "Resurrection" and "Christmas Child" as well as the 2005 missionary drama "End of the Spear."
"That's really his passion ... telling positive, life-affirming messages and Gospel-oriented messages through movies," Mathews said in a phone interview from New York, where she was promoting "Home Run." "We just began to pray and consider what topics would be important. If you're going to spend the time to do a movie, let's make it worthwhile. Do something good for the world."
"Home Run" focuses on fictional professional baseball star Cory Brand (Scott Elrod, who had a small role in the Oscar-winning drama "Argo"), whose alcohol abuse upends his life and career. After he is arrested for driving under the influence and suspended from his team for eight weeks, his agent (Vivica A. Fox, of the "Kill Bill" movies) ships him off to his hometown of Okmulgee, where he reluctantly enters a 12-step Celebrate Recovery program and takes over coaching a local youth baseball team.
Celebrate Recovery is a "biblical and balanced" program that helps people overcome their "hurts, hang-ups, and habits." Offered in more than 19,000 churches nationwide, it is based on the words of Jesus rather than psychological theory.
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Go yourself to the police station.
Call child protective and have a case opened.
This is so wrong.
me BS 52
him - 46
married 15 years DIVORCED 10 31 12
children - ds15 ds12
d-day 12-19-11
I gave a 24hour ultimatum then went to attorney next day
Divorce filed
I agree this is beyond wrong.... I am still in shock. I am still wondering what the hell they saw to make them say they dont have a case and it was closing? How much abuse does it take for our justice system to really step up to keep the victims safe and put away the man that is causing all the pain, breaking all the rules left and right. Does it take until they are gone? I just am so shocked......
I hate police, seriously. How dare this detective not bother to interview the kids but instead interview an abusive asshole and then send the kids back there.
Definitely go to his supervisor - his lack of care in this case is bordering on criminal neglect. Be sure to tell the supervisor that if your kids are abused again you intend to file charges against the detective division for criminal negligence or misconduct or any charge you can make stick. After all, any further abuse is solely because of their failure to properly do their job.
Lazy pricks.
I assume with bruises and marks that have lasted 18+ days you have already taken him to a doctor but if not - take them to the doctor. Doctors and nurses are also MANDATORY reporters of abuse.
Do all these things. See all these people. Get yourself a paper trail that cannot be dismissed.
Call CPS and get the case reopened. Show them the photographs. Show them the doctor's report, the counselor's opinion, etc.
Time for the mama bear claws to come out.
Hang in there!
This POS has beat you in front of the kids..stalked you..had a RO..there is a shit ton of evidence against this POS..all showing him to be an abusive asshole..and this fucking detective believes the word of a known abuser?? And he doesn't even bother to speak with the victims?
I agree...go to the police station and ask to speak to the head detective.
I don't see how they can say there isn't enough evidence here. I don't understand why they aren't speaking with the children.
I will pray that they won't suffer any further abuse this weekend while they are with him. Im sure he is pissed that they told.
Hey..he violated probation by leaving the state..what happened to that? Are they just going to look the other way on that too?
..that feeling you get in your stomach, when you heart's broken. It's like all the butterflies just died.
Yes confused I have been at a loss of words over the last 10 months. He has stalked me, barged in on my very sick mother, telling her he would stop at nothing to get my kids, text me and ask me to come to his house to have sex and leave the next morning to go to work - and they have YET to ever do anything on a TPO violation ... he wont pay support, and I cant get him served as he wont answer the door and because he is self employed I can not get a garnishment so I am still fighting that.
And then yes NOW this - I am beyond upset. I am thinking of emailing our local news department in all honesty. I am truly at a loss of words. I have tried to file several reports of BLANTANT violations against my ex and every time the damn cops tell me it is a civil custody issue, take it to court we cant help you.
Keep in mind I let a LOT of what he does go. I only have tried to report major things and He still gets away with everything and anything. It makes me sick.
I tried to call the kids and they didnt answer. I am a basket case.
Yes my kids are in counselnig and the counselor has mentioned callnig CPS to file a report. I havent followed up with her yet but I believe her. She cant stand him and in my counseling sessions told me how he will NEVER stop. It is not about the kids, this is about control. He is still trying to control me. He even went after my best friend who is a cop (not same county as I live in and where I am trying to fight him at) but he is a cop. He loves his job and has done it for 12 years. He gave us a place to stay when we left that day back in October.
Well NOW my ex has the interanl affairs folks investigating him of using his 'police' power to get my ex arrested when It should have been me to go to jail that day. I was floored when I found out all the allegations my stupid ex put in a SWORN statement. My poor friend is not in great jeorpardy of losing his job over a idiot that gets away with anything and no one seems to want to stand up to him.
So I have tried to not ask him any questions. He was also floored on what has been going on with the legal system. He told me he lost faith in the justice these days. I know the feeling big time.
Here is my goals this week:
Contact the SHERIFF himself Monday morning and get a sit down meeting.
Follow back up with CPS to see about getting a case with them for the kids.
Finding an attorney to file emergency hearing in our town for Sole Custody NO Visitation.
Follow up with Counselor on her behalf of her reports.
Be back in counseling with kids and myself.
And maybe call local news depending on how the talking to the sheriff call goes.
Thank you all again for listening to me and giving me advise. I am a basket case this week - I just do not know what more they need for abuse... :(
They are going to get his cell records to see where his phone pinged that day and if it is over state lines, then yes he will have what they call a revokation hearing. That is when the judge will revoke him to go to jail for x amount of days (usually 60 here where I am at)
I am not sure how they proceed on that. I just make a report - I dont get any other info other than they will definitely find out. I just cant believe this is my life. Was enough to be cheated on, then being abused, but now my kids. This part I can not handle. I am about to lose my marbles literally and I do not want to go do something I will regret :( But damn... when does it stop?????
I had the same thought..about calling the news stations. I would wait until after talking to the sheriff and CPS, and your counselor. If no one can help, maybe that should be your next step.
Im not surprised he isn't letting the kids call you. Unless it's in the visitation agreement, chances are, he won't allow them to call you at all. He wants you to worry. I think he sounds insane.
I hate this for you.
What the hell is wrong with that detective?? What a lazy POS! How does he sleep at night knowing what is going on with your babies and doing nothing??
I am spitting nails for you teeghan.
I vote for the news media. Up here we have some wonderful "dog with a bone" investigators. They DO NOT let up with DSHS. And DSHS has been in so much shit they do not like to have everyone know how worthless they really are.
Yes, not letting your babies talk to you is just his messed up thinking of controlling you. Doesn't give a shit what your babies need/want.
Sending all my prayers and strength to you, and your babies.
Hang in there. Be strong and keep up the fight for your little ones. Sending hugs your way!
Double Betrayal D-Day 7/26/2013
Divorced 11/18/2014
Two steps forward and one step backwards, is still progress.
Stay strong. Stay safe. Stay LEGAL. Ok?
Sending prayers and thoughts your way.
You've done everything, Every Freaking Thing, that you were supposed to do and you've been shit upon by this PD at every turn. Time to go after them, and then bump this up the line to the media. I would also get in touch with your local state representative and make sure that they get photos of your children's wounds.
Screw the locals. They obviously are completely worthless.
D-Day, June 10, 2012
I was absolutely horrified after reading this whole topic. Someone said "Definitely go to his supervisor - his lack of care in this case is bordering on criminal neglect. Be sure to tell the supervisor that if your kids are abused again you intend to file charges against the detective division for criminal negligence or misconduct or any charge you can make stick. After all, any further abuse is solely because of their failure to properly do their job." Great advice IMHO. Put the fear of God into that police department regarding anything else happening to your babies.
You seem to have it all together, are doing all the right things. You MUST be sure his visitation rights are stopped before his PO puts him back in jail, cuz he's gonna be pissed, and he sounds like a scary, scary man.
My heart bleeds for you and your brave children. You are a wonderful mother, I am in awe of your strength. Thoughts and prayers coming hard.
Please keep us updated. . .


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Fugitive lip biter arrested in California
Nov 6, 2014
Jonathan E. Benedict
Oct 30, 2014
Darrell W. Cook
Oct 2, 2014
Michael Polchies
Sep 25, 2014
Home » News » Crime
For League of Women Voters, prison system is a shambles
Sponsored by the Hollis Women's Club, "Take the Keys and Lock Her Up," is the result of three years of research by members of the League of Women Voters of New Hampshire, who are now sharing what they've learned.
The talks offer some background on the state's decision to defend against a lawsuit filed by four women inmates at the State Prison for Women in Goffstown, alleging the state is violating their constitutional rights by failing to treat them the way male inmates are treated.
"There's a vast expanse of difference in how we are treating men and women," said league co-president Liz Tentarelli, who headed up the study with league vice president Peg Fargo.
According to Tentarelli and Fargo, men at the state prison on Concord have access to medical care when they need it. But at Goffstown, state budget cuts now mean there's no back up for a staff that's already stretched thin. If the Goffstown nurse calls in sick, there's no infirmary that day and inmates who are sick stay in their cells.
At Concord, a mental health staff provides consistent care for male inmates with structured group treatment and activities, crisis intervention and a special unit for the mentally ill.
"They are not providing adequate treatment for mental health and substance abuse at the Goffstown women's prison," said Tentarelli.
Fargo said there's a tremendous need for those services.
As many as 90 percent of the women in the prison have drug- or alcohol-related issues, said Fargo. A large majority have trauma-related problems. They have been abused physically or emotionally at some time in their lives.
At Concord, men can attend classes and study for high school diplomas four days a week. Teachers spend the fifth day at Goffstown.
An industrial training program at Concord offers inmates a chance to learn trades such as building wooden furniture, upholstering, graphic arts and cooking.
"This is what women learn for skills," said Tentarelli as she clicked a button on a laptop that flashed an image of crocheted baby blankets and hand-painted birdhouses on the screen above her head.
For the women there is no training for skills that would provide a competitive wage, she said.
Part of the problem is the old building at Goffstown, which doesn't have space for those types of programs. It also doesnt have space for the inmates. The building has room for 105 inmates. There are currently 127 women there but, in the past, there have been as many as 140.
At one point there were 60 women sharing three toilets, said Fargo.
The League of Women Voters is the fourth group to study the conditions at Goffstown, and no one denies there are problems. And just about everyone agrees that a new system with better services is the key to helping inmates rebuild their lives and avoid returning to prison once they are released. But for years, the state Legislature has voted against spending $37 million to build a new women's prison, Fargo said.
The cost of construction has risen to $42 million, and the state is waiting to hear from a consultant hired to review bids from private companies interested taking over the entire prison system.
The League is researching the privatization of prisons and, so far, members aren't optimistic about what they've learned.
"It's our great hope that this might be our year," said Tentarelli. "We are hoping that a new group of legislators will begin to look at a better solution. It's still a very punitive system when you put people in a facility where there is no hope."
The League has looked at different solutions and when members return to Hollis on Feb. 6, they will talk about alternative sentencing for non-violent offenders.
The last talk of the series will focus on the option of privatizing prisons and on education and training and how to help women become self-sufficient.
For Fargo, the immediate goal is to start the conversation on the impact incarcerating women has on those individuals, their children and families, and their cities and towns.
"This is a time when New Hampshire should be sitting down as a group trying to figure out what we want to do here," she said.
"What do you want to do?" she asked the small crowd in Hollis. "These women will be released and they are coming back to your community."
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Police searching for person stealing from cars in ManchesterREADER COMMENTS: 0
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Jury acquits Mont Vernon driver, who was checking text, in death of former Amherst fire chief
Offend someone? To jail with you!
Driver acquitted in Amherst ex-chief's death
A kinder, gentler House Speaker?
College Football: Wildcats are CAA champs
College Hockey: Providence blanks UNH
- Whom do you think bears the brunt of the blame for the mayhem this weekend in Keene?
- KSC students
- 37٪
- KSC administration
- 2٪
- Police
- 6٪
- Visitors from out of town
- 18٪
- A combination of any/all of the above
- 37٪
- Total Votes: 2483


text:
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About the one I'm looking for...
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I'd just like to add...
I love dogs. I like US history and geography especially; I have seen most of the US outside Alaska, I like the western states specially the southwest, and northern Mexico. But US beaches tend to be crowded. Relatively isolated beaches can be found around the Gulf of California. I have an affinity for and am a fair weather friend of the Arkansas Razorbacks football team. I was born in Little Rock, Arkansas and grew up in Ouachita County, Arkansas, the sixth generation on my mother's side to reside in the County even if it does not contain a good beach but it has a river.
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text:
22 Feb 2013
Estate agencies will be successful if their agents learn how to build trust and to establish a completely open and honest relationship with their clients.
This is according to Lizette Joubert, who has owned and run the Rawson Property Group's Paarl franchise for eight years. She has placed her franchise in the number one or two spot in the area she serves making it safe to say that her opinion on the ingredients that make for success is bound to be noteworthy.
She says estate agents will have to know their "subject" and have all the essential data on the local property scene and how its prices have fared recently and in the past. They must also know how interest rates have performed and what they are likely to do in the future and they have to be able to advise their clients on how to pre-qualify for a bond. Then they must know everything about their town or precinct and the factors which can determine whether it a pleasant place to live.
After ensuring the client understands all of the above thoroughly, agents must then show their client that they are never far from their thoughts and their interests are being attended to. Whether the client is selling or buying, regular feedback is essential, says Joubert as silence on the part of the agent will be taken to mean that he is inactive or has lost interest. Even in the most hopeless situations, where there has been no activity at all, she says the client has to be kept informed as often as possible.
Coupled with these knowledge and service attributes, Joubert says a good agent will be known to be truly ethical.
She adds that unfortunately, in the estate agency world, there has been a share of those who have sailed close to the wind and whose morality is suspect. However, once it has been established that an agent will reject involvement in any shady deal, even if it is profitable to him, his reputation and the number of clients he attracts will grow.
She believes this is the reason why certain Rawson Properties Paarl agents have clients who have done numerous deals with them and established a trusting relationship. "Franchise principals such as myself have to be absolutely ruthless in ensuring that the ethical foundation on which the business is being built is understood and adhered to by the entire team." Any overstepping of the line is dealt with at once and it should be made clear that any agent trying to go this route can't be part of the team. Joubert says once this is established and understood, it is amazing how teams can thrive and succeed.
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- 4/7/14 /
- Comment
Gary Cole on Veep, Will's Death on The Good Wife, and the Christopher Walken Rule
After seeing Will die on The Good Wife, he went, "Wow, okay — they're really going over the edge!"
Skip to content, or skip to search.
After seeing Will die on The Good Wife, he went, "Wow, okay — they're really going over the edge!"
"We probably cut 20 words out of 1 million from the show tonight."
Following an intracranial hemorrhage earlier this week that left him in a coma, Gary Coleman has been taken off life support by his wife, Shannon.
Former child star underwent emergency surgery.
"If you get hit by a bus tonight, I don't care."
Pull up a chair, why don't ya?
"Gary's typically unhappy a lot, but oddly enough, at the same time, that's what makes him happy."
Coleman on his new movie: "It was worse than any film school project ... I shouldn't be in this movie in the first place, but the mortgage keeps coming."
Mike Judge picks Jason Bateman to star in a comedy, finally. Plus: Gary Coleman goes to court.
The pants are a size XL 12 regular from Gap Kids and, as the description notes, "would be perfect for any child who loves Gary."


text:
Jun 01st 2014
2014 Best of the Beehive Food Survival Guide
Here are some essentials for eating well in the Beehive. Read More
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Traditional Belgian cuisine at Bruges Waffles & Frites Read More
Do yourself a favor of flavor and try out Vinto's Pizzeria this summer! Read More
Bring a little sweetness to your salsa with Red Iguana's Salsa de Uña, complete with fresh mangos, oranges and limes. Read More
It's basically summer, which means the oven should be turned off. Get the season started with this recipe from Red Iguana. Read More
Walk and dine in downtown, SLC. Read More
Craving something seasonal, fresh and flavorful? May we suggest preparing pasta primavera? Read More