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Clive Palmer says more state MPs will desert the LNP for his party, but not before September's federal election
- From: The Courier-Mail
- May 22, 2013
BILLIONAIRE miner and aspiring Prime Minister Clive Palmer has predicted more State MPs will desert the LNP for his fledgling party - just don't expect them to jump before the September federal election.
Speaking at one of his frequently-held press conferences outside State Parliament today, Mr Palmer said his Palmer United Party would stand candidates in every state electorate.
But he said he did not expect current LNP sitting MPs to change teams until after September because they were "worried about their skin."
"I think you will find a lot of them joining us after the next federal election because that's what politicians are like. They are all worried about their skin," Mr Palmer said.
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2 4 6 8 NO more Violence! No more hate! My signs for TAKE BACK THE NIGHT! #yyc By Brighteyedwanderer
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High levels of plant-based estrogens discovered in some industrial wastewater.
Washington, August 11 (ANI): Civil engineering researchers in the University of Minnesota's Institute of Technology have discovered high levels of plant-based estrogens Estrogens
Mentioned in: Acne, Polycystic Ovary Syndrome
estrogens (es´trōjenz),
n. , called phytoestrogens Phytoestrogens
Compounds found in plants that can mimic the effects of estrogen in the body.
Mentioned in: Premenstrual Syndrome
n.pl plant-derived estrogen analogs. , in some industrial wastewater.
In the study, civil engineering associate professor Paige Novak and her graduate student researcher Mark Lundgren studied wastewater streams from 19 different industrial sites in Minnesota and Iowa and analyzed them for six phytoestrogens.
They found very high concentrations of these hormone-mimicking phytoestrogens - up to 250 times higher than the level at which feminization feminization /fem·i·ni·za·tion/ (fem?i-ni-za´shun)
1. the normal development of primary and secondary sex characters in females.
2. the induction or development of female secondary sex characters in the male. of fish has been seen in other research - in the wastewater discharged from eight industrial sites, including biodiesel plants, a soy milk Soy milk (also called soya milk or soybean milk) and sometimes referred to as soy drink/beverage and even soy latte) is a beverage made from soybeans originating from China. factory, a barbecue meat processing facility and a dairy.
They also detected high concentrations of phytoestrogens in the water discharged by some municipal wastewater treatment plants Wastewater treatment plant also called wastewater treatment works
- Sewage treatment – treatment and disposal of human waste.
- Industrial wastewater treatment – the treatment of wet wastes from manufacturing industry and commerce including mining, quarrying and
The good news is that the researchers revealed that phytoestrogens can be removed from water as it goes through standard treatment.
In fact, they saw more than 90 percent removal of these compounds from the water.
Unfortunately, sometimes 99 percent removal is needed to reach levels that are considered harmless to fish.
Plant-based phytoestrogens are naturally occurring but have been shown to function as hormone mimics and alter development and reproductive patterns in fish.
These effects include decreased aggression, immunosuppression immunosuppression
Suppression of immunity with drugs, usually to prevent rejection of an organ transplant. Its aim is to allow the recipient to accept the organ permanently with no unpleasant side effects. , and decreased testosterone production.
Other estrogens that cause similar effects have been linked to population-level collapse in fish, according to according to
1. As stated or indicated by; on the authority of: according to historians.
2. In keeping with: according to instructions.
3. Novak.
"Many people have looked at human-related chemicals such as those in birth control pills birth control pill
See oral contraceptive.
birth control pill Oral contraceptive, see there as the primary source of estrogens in the water supply, but they have not looked at plant-based estrogens from a wide variety industries," Novak said.
"Our research is the first study of its kind to provide a snapshot in time of what is going on in these industries. We hope that it can be used in planning new industrial sites and expansion of current sites," she added.
Novak pointed out that some of these industrial facilities are in small towns without sophisticated wastewater treatment plants.
In these locations, there is potential for impacts on fish and wildlife.
"Our nation (US) needs to do some careful planning as we rapidly expand various plant processing industries," Novak said.
"We need to include good wastewater treatment into our industrial plant designs.
We also need to think broadly as we look for the causes of fish feminization in various streams, rivers and lakes, as well as possible solutions," she added. (ANI)
Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved.
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Derbyshire go for Morris
Derbyshire have appointed John Morris as the club's new head of cricket.
The former England international scored 13,489 runs during an 11-year spell between 1982 to 1993 at the County Ground, averaging over 40.
The 43-year-old, who played in three Test matches and eight one-day internationals for England, replaces former Zimbabwe captain David Houghton after he left the post before the end of his contract.
Morris said: "I am highly delighted to be here. I have never lost the love of the game since I retired from playing and to come back to my roots and represent the team with which I made my name as a player is a wonderful feeling.
"Cricket is in by blood, it is my life and it is now up to me to prove myself within management and to take this club forward."
Morris, who won the Sunday League and Benson and Hedges Cup with Derbyshire before spells with Durham and Nottinghamshire, added: "I will do things my way and some changes will be made.
"But I know that there is enough desire and ability within this club to take it forward and to be a competitive team in first-class cricket.
"I am not saying that I have got all of the answers, of course I haven't, but there will be a philosophy in place of how I want the team to play cricket and I will bring strong leadership to the camp.
"My philosophy is play it properly, play it well, play it with a smile on your face and let's learn how to win."
Derbyshire chairman Don Amott added: "I am delighted that John has been appointed our new head of cricket and I have every confidence that he can bring us success on the pitch to match the progress we are making off it.
"Our main focus will always be trying to improve our cricket and compete at the top of the domestic game and we will give John all the support he needs to achieve that.
"I am sure all Derbyshire members and supporters will get behind John and the squad as we move forward."


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Will BCCI finally be forced to act?It finally had to be the Supreme Court of India that needed to remind the Board of Control for Cricket in India (BCCI) about the meaning of the word propriety. That cricket is a gentleman's game and needs to be governed as such. That by turning a ... Cricbuzz.com, 1 day ago
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Will BJP still back Srini?
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'BCCI conveniently bends the rules to suit itself'
Former cricketer-turned-MP Kirti Azad tells Rediff.com's Manu Shankar that Narayanaswami Srinivasan is equally responsible for the mess in Indian cricket, even if he is not involved. A policeman walks past a logo of the Board of Control for Cricket in India (BCCI). Photograph: Arko Datta Accusing the Board of Control for Cricket in India of having double standards, former cricketer-turned-Member of Parliament Kirti Azad said it lives by the motto 'you show us the man and ...Rediff.com, 6 days ago
CAB keeps Srini waiting, to support only after Jaitley nod
ded to keep their cards close to their chest as its supremo Jagmohan Dalmiya "refused to commit his support" for president-in-exile N Srinivasan and has told him that he will do so only after receiving the nod from Arun Jaitley. Srinivasan met ...Business Standard India, 1 week ago CAB keeps Srini waiting News Today, 1 week ago Cricket Association of Bengal keeps N Srinivasan waiting, to support only after Arun Jaitley nod Economic Times, 1 week ago CAB keeps N Srinivasan waiting, to support only after Arun Jaitley nod ZeeNews.com, 1 week ago
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Baroda Cricket Association inks land deal, promises cricket stadium at earliest
VADODARA: The residents of Vadodara may finally get to watch international cricket matches in a world-class stadium. The Baroda Cricket Association (BCA) management on Wednesday signed a land deal for 18 bighas of land in Kotambi that was approved ...Times of India, 3 weeks ago Baroda Cricket Association allows president to sign land deal if issues addressed Times of India, 1 month ago
Burn the orchard,re-grow cricket
Getting Mr. Srinivasan to walk the plank is desirable, but won't rescue Indian cricket. Scrap the BCCI, whole hog, and start over Isn't it reassuring to learn how many men of character the Board of Control for Cricket in India has? With the ...The Hindu, 1 month ago
VEAG opposes Nag river de-notification proposal
NAGPUR: To ensure survival of city's iconic Nag River, Vidarbha Environmental Action Group (VEAG) has decided to register strong opposition to the industrial department's proposal, seeking de-notification of the water body. Requesting not to allow ...Times of India, 1 month ago
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Wine tasting in Italy: Amarone in the Valpolicella
We spent a wonderful July day wine tasting in Italy's Valpolicella region, just north of the city of Verona. Heading out of the B&B (scroll down for photos) after breakfast, we drove through the picturesque countryside, explored a couple small towns, and learned more about the full-bodied Amarone wine that has made the area famous. Valpolicella is…
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Town Square
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AROUND TOWNIs your name Arthur?
Dear Emily, Each year San Ramon invites those named Arthur to their own festival to celebrate that name, as "ART," and...Original post made by Ralph N. Shirlet on May. 18, 2010
There are no comments yet. 734 Views
COMMENTS ON STORIESIdentify your needs when writing college essays
In this week's [http://danvilleexpress.com/square/index.php?i=3&d=&t=3783 Doing College], expert admissions adviser Elizabeth...Original post made on Jun. 27, 2012
Last comment by Dale, on Jun 27, 2012 at 9:28 am | 1 comment | 734 Views
AROUND TOWNAIA meeting, June 9, to discuss MVHS solar power generation station
Dear Editor, Neighborhoods are tracking www.alamoca.org, the Alamo Improvement Association website, for issues impacting...Original post made by [removed] on Jun. 6, 2011
There are no comments yet. 733 Views
COMMENTS ON STORIESDanville council to host second budget review session
The Danville Town Council on Tuesday (May 13) is set to hold its second study session to review the 2014-15 recommended town...Original post made on May. 13, 2014
Last comment by avid bicyclist, on May 14, 2014 at 11:13 am | 3 comments | 733 Views
AROUND TOWNAlamo community on YouTube today, September 17
Dear Dolores, Alamo neighborhood and community groups will gather at Yellow Wood Friday morning between 9 and 11 to be...Original post made by Hal on Sep. 17, 2010
Last comment by Hal, on Sep 17, 2010 at 3:50 pm | 1 comment | 732 Views
AROUND TOWNGet home safely on Cinco de Mayo
On Thursday, May 5, the American Automobile Association will be offering free tow and ride home through its Tipsy Tow program....Original post made on May. 5, 2011
Last comment by Duffy, on May 5, 2011 at 8:09 am | 2 comments | 732 Views
COMMENTS ON STORIESRally post: Meals on Wheels donations
Hi everyone: Another article in this fine publication reports the difficulties of the charity Meals on Wheels of Contra...Original post made by Conservitizen Paintor on May. 2, 2013
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COMMENTS ON STORIESRagin' Cajun raises $100,000+ to benefit cancer patients
The Sandra J. Wing Healing Therapies Foundation's sixth annual Ragin' Cajun fundraiser held earlier this month was "definitely...Original post made on Mar. 20, 2014
Last comment by Judy, on Mar 20, 2014 at 2:37 pm | 3 comments | 732 Views
COMMENTS ON STORIES'Spare the Air' alert issued for Wednesday
The Bay Area Air Quality Management District has issued a "Spare the Air" alert for Wednesday, warning of unhealthy pollution...Original post made on Sep. 28, 2011
Last comment by Derek, on Sep 28, 2011 at 12:12 pm | 2 comments | 731 Views
AROUND TOWNDanville Council campaigns have started in cyberspace
Dear Editor, A volume of e-exchanges have started in our region to generate new candidates for Danville Town Council including...Original post made by [removed] on Sep. 30, 2011
Last comment by [removed], on Oct 6, 2011 at 7:01 pm | 1 comment | 731 Views
COMMENTS ON STORIESStreetwise: What does 2012 have in store?
As election fever picks up and residents begin to enact their 2012 resolutions, Roving Reporter Stan Wharton went t o 24...Original post made on Jan. 5, 2012
Last comment by Steve, on Jan 9, 2012 at 10:44 am | 6 comments | 731 Views
COMMENTS ON STORIESMarchers will 'Occupy' Tri-Valley
Occupy Oakland is headed to Pleasanton to mark the second anniversary of the lockout of workers from Castlewood Country Club....Original post made on Feb. 24, 2012
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COMMENTS ON STORIESLaptops stolen with John Muir patient health info
John Muir Health began notifying more than 5,000 patients on Monday of a potential breach in the security of their personal...Original post made on Apr. 6, 2010
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COMMENTS ON STORIESLocal Sport Clips to help with oil spill
Trimmings and clippings from the Sport Clips Haircuts store at Camino Tassajara and Crow Canyon in Danville are about to...Original post made on May. 13, 2010
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COMMENTS ON STORIESStreetwise: What do you remember most about your mother?
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AROUND TOWNKellogg drops legal dispute against San Ramon-based nonprofit
Toucan Sam will allow other birds to glide through the friendly skies after a legal dispute between Froot Loops maker Kellogg...Original post made on Nov. 28, 2011
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COMMENTS ON STORIES114 flights out of SFO canceled as east coast airports remain closed
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Last comment by Derek, on Oct 30, 2012 at 3:43 pm | 1 comment | 730 Views
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AROUND TOWNStreetwise: How prepared are you for a disaster?
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Page 223.5 of 263
Hayward NAACP officials threaten blog posters
By Tim Hunt | 21 comments | 1,790 views
Not so speedy trial
By Roz Rogoff | 4 comments | 1,274 views
By Tom Cushing | 1 comment | 285 views


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A dozen Burma army soldiers died yesterday morning during heavy fighting with the Kachin Independence Army's (KIA) Battalion 3 in Waingmaw (or Waimaw) township in eastern Kachin State, according to officials from the KIA and local residents.
A KIA soldier suffered minor injuries during one of the two clashes that took place yesterday, according to a fellow member of the KIA's Battalion 3.
The first outbreak of violence happened at the Burma army's Bum Tawng post on the Myitkyina to Kambaiti road at about 7 a.m. The post was previously under KIA control but was abandoned in November of last year.
Witnesses say that three Burma army soldiers stationed at a checkpoint on the road were killed after KIA personnel detonated a series of remote controlled explosive devices. According to local residents government troops usually use the gate to forcibly collect tax from traders and civilians who pass through.
Four hours after the Kambaiti road clash, KIA forces and government troops again clashed at a location between Sambai and Ga Ra Yang village on the Myitkyina to Bhamo (Manmaw) road. At least 9 government soldiers appeared to have died and several more were injured, said a KIA officer serving at the frontline.
After the clashes local residents observed a 20 vehicle convoy carrying what appears to be more government troops pass Shwe Nyaung Pyin village near Ga Ra Yang. It is believed that the ultimate destination for the troops is Waingmaw.
Yesterday in the jade rich Hpakant region of western Kachin State, KIA Battalion 6 soldiers raided the Kamaing police station capturing weapons and ammunition. According to KIA officials four police were killed and three others were injured during the raid.
Although Burma's central government led by ex-general President Thein has promised to hold peace talks with the KIA's political wing the Kachin Independence Organization (KIO), the army continues to attack KIA positions and send more troops to Kachin State.
- Burma army shells land near Kachin IDP camps (News) 25 Nov 2014
- Myitkyina residents defy authorities to mourn 23 Laiza cadets (News) 24 Nov 2014
- Laiza shelling fatalities were from KIO allies, ABSDF, AA, CNF, TNLA (News) 22 Nov 2014
- Government claims Laiza shelling was a "warning shot" (News) 22 Nov 2014
- KIO, UNFC condemn Laiza shelling (News) 21 Nov 2014


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Archive for March, 2008
Good health begins at home
When it comes to promoting health and wellness, Windsor Regional Hospital (WRH) felt it had to look at itself before it could be a mentor to its community. And, it had to start at the top with the President and ...
Health Promotion driving force behind Mount Sinai
Hospital's Family Medicine Centre's approach
Health Promotion driving force behind Mount Sinai Hospital's Family Medicine Centre's approach By Kristen Marano Are you feeling sluggish, energy-drained and tired even though you get a decent night's sleep? These feelings are often the result of an unbalanced diet that includes too ...
Pain management in geriatric population presents
special challenges
A health-care team at Baycrest recently worked through a difficult case that offers valuable insight into what a complex pain and management assessment looks like in the geriatric population. The case involved an 80-year-old woman from an assisted-living seniors' building with ...
Tackling pain management in young patients
Recognizing the importance of pain management in children, the Children's Hospital of Eastern Ontario (CHEO) is tackling pain management in a coordinated fashion. Following a Quality Improvement report that identified the need for improved pain management services at CHEO, a working ...
Immunity: The natural "cure" for the common cold
Supervising naturopathic doctors (ND) and fourth-year clinic interns at the Robert Schad Naturopathic Clinic (RSNC), the teaching clinic at the Canadian College of Naturopathic Medicine (CCNM), have had their hands full this winter. "Winter is always a terrible time for ...
Ongoing education ensures sustainability for Joseph
Brant Memorial Hospital Pain Resource Nurse Team
More than seven years ago a multidisciplinary team at Joseph Brant Memorial Hospital came together to focus on pain management, share ideas and develop strategies for addressing patient pain. That proactive and progressive approach was manifested again in June 2006 ...
Music to their ears
George Linton has been making high-powered connections since 1975. If you've conjured up an image of a high-powered executive making high-powered deals, you'd be way off base. In real life, George Linton connects people with music. For several hours every ...
A stepping stone approach to managing pain
You can always smell when the spring season is upon us. With this season comes the feeling of hope and anticipation of what good things lay ahead. For the employees and partners of SCO Health Service this hope also comes ...
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Healthcare that (almost) makes house calls
A cancer diagnosis can be traumatic for not only the patient but also family members and caregivers. Feelings of stress, anxiety, sadness, anger […]Read more →
Facilities Management and Design
Ultraviolet and HVAC: Keys to reducing hospital acquired infections
The use of ultraviolet light systems is becoming more widely used in healthcare facilities for disinfecting patient and operating rooms. Yet, ultraviolet lights […]Read more →
Infection Control
Hospitals weigh-in on flu shot or wear a mask policies
More than voluntary and less than mandatory: What some hospitals have learned so far about implementing 'get a flu shot or wear a […]Read more →
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Patient satisfaction is served
Patient experience surveys in Ontario consistently find a link between satisfaction with hospital food and overall patient satisfaction. Comprised of different backgrounds, cultures […]Read more →
Evidence Matters
Proton Pump Inhibitors: Are we doing no harm?
Ongoing stomach and digestive problems can be miserable for patients – and are a common cause for visits to a health care professional. […]Read more →
Health Care Policy
Putting patients at the helm of symptom management
Cancer Care Ontario (CCO) is completing the Systemic Therapy Ambulatory Toxicity Management (AToM) Pilot which takes a patient-centred approach to improve how treatment-related […]Read more →
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Defining the patient experience
You'd be hard pressed to find anyone who would choose a hospital stay over a trip to Disneyland. However, as Fred Lee controversially […]Read more →
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Meal-time patient hand hygiene initiative shows promise
The recently launched meal-time patient hand hygiene initiative at Quinte Health Care (QHC) is having amazing results. The number of patients contracting antibiotic […]Read more →
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The power of people: Enhancing the patient experience
As health care workers and leaders, it's our job to provide expert, compassionate care to our patients. We go to school, get our […]Read more →
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A comprehensive approach to enhance patient experience
When Gordon Newman was invited to join William Osler Health System's (Osler) Patient Experience Advisory Committee, he eagerly accepted. As a former patient, […]Read more →
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Telemedicine pilot improves withdrawal management care
Since the late 1990s, the Ontario Telemedicine Network (OTN) has offered two-way videoconferencing to increase access to patient care and education for health […]Read more →
Patient and Staff Safety
How one hospital made hand hygiene rates soar
Royal Victoria Regional Health Centre (RVH) takes its commitment to safety seriously. In fact, that unwavering focus on quality care is our highest […]Read more →
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I am the patient experience
Michael Stern is a fighter. For two years he had been fighting prostate cancer until he underwent a radical prostatectomy – a surgery […]Read more →
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Researchers create "black box" for use in operating rooms
Researchers at St. Michael's Hospital have developed a "black box" for use in operating rooms, similar to that used in the airline industry. […]Read more →
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Enteroviruses cause a wide range of illness; most are associated with the common cold, but others are associated with lower respiratory tract, skin […]Read more →
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Measuring the quality of client and family engagement
Woven into the fabric of Holland Bloorview Kids Rehabilitation Hospital is the client and family voice. To ensure client and family voices are […]Read more →
Flu vaccines and Ebola relief – do we have duties to get and to give?
Over 40 years ago, philosopher and ethicist Peter Singer published an article called "Famine affluence and morality". The piece argued that we ought […]Read more →
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First hospital in Canada with completely paperless medical record system
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Education program enhances dementia care
Before every shower, Jerry* would resist, kick, hit and yell. Staff at The Scarborough Hospital (TSH) couldn't understand why bathing caused him such […]Read more →
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Would your employees recommend your hospital as a great place to work, learn and grow? Would they say that they trust your organization? […]Read more →


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Will Chinaĺs Air Defense Zone Chill Trade?Thomas J. Bollyky interviewed by Beina Xu
New Chinese territorial claims over the East China Sea have alarmed trade partners and neighbors, but no major disruption in the region's...
Speaker: Charles E. Schumer, Member, United States Senate (D-NY)
Presider: Nancy E. Roman, Vice President & Director, Washington Program, Council on Foreign Relations
June 9, 2005
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Maximalist finds lessons in the past that anticipate and clarify our chaotic present, revealing the history of U.S. foreign policy in an unexpected new light. More
This clear and authoritative book presents a sweeping account of China's global resource quest and the unrivaled expansion of its economy. More
The story of the tragic and often tormented relationship between the United States and Pakistan, and a call to prepare for the worst, aim for the best, and avoid past mistakes. More
This Independent Task Force asserts that elevating and prioritizing the U.S.-Canada-Mexico relationship offers the best opportunity for strengthening the United States and its place in the world.
This Independent Task Force report finds that as more people and services become interconnected and dependent on the Internet, societies are becoming increasingly vulnerable to cyberattacks.
The authors argue that it is essential to begin working now to expand and establish rules and norms governing armed drones, thereby creating standards of behavior that other countries will be more likely to follow.
The author examines Pakistan's complex role in U.S. foreign policy and advocates for a two-pronged approach that works to quarantine threats while integrating Pakistan into the broader U.S. agenda in Asia.
The authors assess the political, security, and economic challenges facing U.S. policymakers in Afghanistan and evaluate a range of policy options.
Learn more about CFRĺs mission and its work over the past year in the 2014 Annual Report. The Annual Report spotlights new initiatives, high-profile events, and authoritative scholarship from CFR experts, and includes a message from CFR President Richard N. Haass.
Read and download »
New Chinese territorial claims over the East China Sea have alarmed trade partners and neighbors, but no major disruption in the region's...
Shanghai's new free trade zone promises to be a testing ground for China's economic reform, but its innovations should be assessed over time,...
Tensions between China and Japan are rising, but an economic version of mutual deterrence is preserving the uneasy status quo. Put simply,...
Michael Spence writes that cooperation between the United States and China on issues surrounding the environment, trade, investment, and...


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if we can further anti-gravity technology, space travel should be much simpler hence less expensive.
Welcome to Unexplained Mysteries! Please sign in or create an account to start posting and to access a host of extra features.
Commercial space flights possible in 2008
They will be pricey though...
Started by Rykster , Feb 13 2006 03:26 PM
Started by Rykster , Feb 13 2006 03:26 PM
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|$250 per person security deposit for any apartment or
townhome ($750 max), and no application fee!
|Not in Lawrence? No problem!
Download an application from our website and pay your deposit over the phone
with a Visa or Mastercard. We'll take care of the paperwork by fax or email. See
our leasing page for details on how to solidify your new home, or send an inquiry
to one of our leasing consultants.
|Get info on the Lawrence Transit/KU bus route on our
Bus Route Info page, or visit their website.
Meadowbrook has instituted a permanent resident referral program
that can earn you credit on your rent account. Ask your leasing agent
how you can benefit from referring your friends to Meadowbrook!
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open regular hours on Friday, November 28, and
Saturday, November 29. If you would like to visit our
community, call our office and set up an appointment with
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|Apartments and townhomes available in December and
January are now posted on our Current Availability page.
Studios and one-bedrooms are going quickly, so call a
leasing agent today to set up a visit.
We have also taken several reservations for August,
2015! With a Fall Reservation Program, you can reserve
your home for next year right now--ask a leasing agent for
more details.


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HBO Go Now Available on Apple TV, Also Adds ESPN and Sky TV
Despite Game of Thrones Season 3 just coming to a close, Apple TV today added HBO Go to their list of available channels. The software update, which should be available as of today, also includes access to WatchESPN, UK's Sky News, anime site Crunchyroll, and music concert and documentary streaming service Qello.
Needless to say, you'll need to have a cable/sat subscription that includes access to HBO and ESPN, while UK's Sky TV is said to be available for free to US, UK, and Ireland Apple TV owners.
Crunchyroll offers a 7-day free trial that rolls over into a $6.99 a month subscription. Macrumors says a $11.99 a month subscription providers more exclusive access. Qello also offers a 7-day free trial with a $4.99 a month subscription that provides unlimited access to their library of concerts and music documentaries.
The Apple TV update, software version 5.3, can be downloaded now for the Apple TV generations 2 and 3.
Christen Costa
Grew up back East, got sick of the cold and headed West. Since I was small I have been pushing buttons - both electronic and human. With an insatiable need for tech I thought "why not start a blog focusing on technology, and use my dislikes and likes to post on gadgets."
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AllCast Returns To Chromecast
Samsung Wins Ban On iPhones And iPads Nobody Uses Anymore Anyway
Have All The Sensors With The NODE Wireless Sensor
HooToo TripMate Is A Portable Charger And A Travel Router As Well
The Gala Ring Is A Business Card On Your Finger
Ad Campaign Rewards a Free Samsung Galaxy S4 When You Stare At It for 60 Minutes Straight (video)


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Author Archives: William S. Lind
That Old Romanov Feeling
America loses even if it wins a war with China.
Leaner, Meaner Marines
Even with a Taftian foreign policy and a defensive grand strategy, America …
Building a Navy That Won't Sink the Economy
America is by geography a maritime state. Even with a vastly shrunken …
Reshaping the Pentagon for an Age of Austerity
The systemic crisis now beginning to engulf the United States, Europe, and …
Battles Won, Wars Lost
By William S. Lind | August 22, 2011 One of the rules …
Turning Libya Into Somalia
In mid-April, I was asked to participate in a "Libya Workshop" in …
Generation Gap
By William Lind | May 5, 2011 A central tenet of the …
In the Middle East, Tyranny May Give Way to Anarchy
By William Lind | March 30, 2011 As the American foreign-policy establishment …
A Tea Party Defense Budget
Tea Partiers rightly fear national ruin unless government spending is reduced. The …
His Majesty's Birthday
The Kaiser Warns that American Exceptionalism Violates the Laws of History By …
War for Women
Feminist ideology wins in Afghanistan By William Lind The interesting question about …
Rail Against the Machine
What's so conservative about Federal Highways? by William S. Lind Conservatives do …← Older posts Newer posts →
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Updated: 07/28/2014 8:30 AM |
Created: 07/28/2014 8:21 AM
By: Nikki Ibarra, KOB Eyewitness News 4
A brand new overpass opened to traffic on Paseo Del Norte Monday morning.
The Jefferson overpass, which is an above-grade bridge for eastbound and westbound Paseo Del Norte traffic, is one of six major improvements of the Paseo/I-25 Interchange project. It is designed to allow Paseo Del Norte traffic to flow freely over Jefferson Street NE while still providing access to the interchange and better flow for northbound and southbound traffic on Jefferson.
A number of major closures took place on Paseo over the weekend while crews finished up the overpass.
Construction for the project is expected to be completed in December 2014.
KOB welcomes a lively and courteous discussion as long as you follow the rules of conduct set forth in our Terms of Use. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Use.
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All News & Blogs
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Visit the Photo Place
Theresa A. Gailliot
Theresa Ann Gailliot, 71, of Fredericksburg died on Saturday, April 26, 2014.
She was the beloved wife of the late Martin A. Gailliot; mother of Scott and Steve; stepmother of Ali, Maggie and Martin; dear grandmother of Anthony, Olivia, Zoe, Kaia and Martin III; and sister of Janice.
Theresa was very involved in youth sports, coaching baseball, basketball and soccer through the years.
Services and interment will be private.
In lieu of flowers, the family requests donations in Theresa's memory go to the Spotsylvania Regional Medical Center.
Services are under the care of the Demaine Funeral Home, Springfield.


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4.2 cu. ft. Built-in Refrigerator/Freezer Combo with 3 Removable Tempered Glass Shelves, 8 Lbs. Daily Ice Production, 8 Lbs. Ice Storage Capacity and Interior LED Lighting
Our Price
4.2 cu. ft. Compact Refrigerator with 1.5 cu. ft. Freezer, 3 Removable Tempered Glass Shelves, Digital Touch Pad Control, LED Lighting and Star K Certified
24" Built-in Combo Ice Maker/Refrigerator with 8 lbs. Daily Ice Production, 13 lbs. Ice Storage, No Drain Required and 4.2 cu. ft. Refrigerator Capacity
5.2 cu. ft. Compact Refrigerator with 3 Removable Tempered Glass Shelves, 123 Bottle or 185 Can Capacity, Energy Star Qualified, Digital Touch Pad Control and Star K Certified: Stainless Steel
21" Built-in Combo Ice Maker/Refrigerator with 2.1 cu. ft. Refrigerator Capacity, 8 lbs. Daily Ice Production and No Drain Required
2.1 cu. ft. Compact Marine Refrigerator Freezer Combo with 24 12-oz. Bottle Capacity, 44 12-oz Can Capacity, 8 Lbs. Ice Production Per Day and 2 Fixed Door Compartments
24" Undercounter All Refrigerator with 5.3 cu. ft. Capacity, 4 Heavy-Duty Wire Shelves, Convection Cooling, Door Lock, ADA Compliant and Glass or Solid Door Option
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Cardiff by the Sea House Rental Photos and Description
Custom, gourmet kitchen/4 bedrooms/3+baths. Ideal for Del Mar Racetrack Folks!
Are you looking for a luxurious custom home with spectacular – panoramic ocean views?
Would you like to sit at your very own kitchen table…living room… or balcony and watch:
•Amazing sunsets each evening?
•Dolphins and surfers frolicking in the surf?
•A peak of Catalina Island off in the horizon?
•Whales "spouting" off in the distance? Wow.
Would you and your family like to stay really, really, really close to the beach?
Yes- just a quick 7-minute walk- and you are there!
•500' and 7 minute walk to Swami's Beach
•Moonlight Beach
Would you and your family like to vacation at an exquisitely decorated, new custom home that accommodates up to 9 people and is equipped with:
•4 bedrooms and 3 ½ baths --including 2 masters with en-suites and walk in closets?
•A gourmet kitchen- with granite counter tops and top of the line appliances?
•Total privacy behind a gated entry?
•A fabulous media system with CD, DVD, great sound system, wireless Internet, large flat screen TVs in each room, Cox Cable with HBO and Showtime, all controlled by easy to use remotes?
•Laundry room with high-end appliances?
•Outdoor shower for surfers and beach goers?
•Towels, bedding, fully stocked kitchen, and just about any thing you could want! Just bring your own beach towels, food and beverages and you are good to go!
Would you and your family like to stay within walking distance of quaint and historic downtown Encinitas and Cardiff?
Just a 5-10 minute walk to:
•3 grocery stores
•2 farmers markets
•Restaurants, bars and fine dining?
•Tons of shopping
•Amtrak and the Coaster train
•And, much, much more.....
Yes, the Cardiff beach House is located a mere 5-10 minute walk from both downtown Encinitas and Cardiff where you can find just about anything you could possibly want. Or, if you choose, you can even ride our bike!
Would you like to stay in an ideal location for vacationing throughout San Diego?
Located in north coastal San Diego, the Cardiff Beach House is truly the perfect location. It's close to Del Mar, the Del Mar Racetrack, Rancho Santa Fe, La Jolla, Torrey Pines, UCSD, the gliderport, high-end golf courses, shopping, La Jolla, dining, Legoland, the zoo. Plus++++
If so, you will love the Cardiff Beach House!
I think when you add it all up, you will know you found the perfect spot for your next vacation. Just give us a call or contact via email/ vrbo as soon to book your vacation!
Open to both short term and long term rentals. Extra discounts apply to longer term rentals.
Note: Kitchen, living and dining area is on the 2nd floor to maximize views. There is a flight of stairs (in 2 sections) that total 18 stairs. My 81 year old disabled mother was able to use the stairs- but might be an issue for others.
Likewise, the house is not fully baby proofed. We would, however, consider adding a baby gate and protectors for electric sockets if requested.
Although the beach is only 500' as the bird flies, one has to walk ~ 6 blocks to get to Swami's beach access point. There are many beaches in the area- some of which offer easier access for elderly and those that might have a difficult time with stairs and hills. Moonlight Beach has the easiest access.
Allergies? Occasionally our cat joins us when we are staying here. THe house is very clean- and have not had any problems- but just want potential renters to know ahead of time.
Questions? Just give me a call:)
- Suitability:
- Long-term Renters Welcome
- Minimum Age Limit for Renters
- children welcome
- non smoking only
- pets not allowed
- wheelchair inaccessible
About Libby Scott
Originally from Illinois, Doug & Libby Scott moved to the north coastal portion of San Diego over 26 years ago. They have 3 kids- all of which are in college and grew up in the area.
Doug, Libby and kids have enjoyed their time in Encinitas/Cardiff. Doug, a runner, hiker and biker tries to find time for adventures while Libby- is always looking for the 'perfect' photograph and adopting a non-profit to get involved with. Libby, a professional photographer recently closed her gallery in Northern Wisconsin and is now focusing her art on the San Diego area. Check out the artwork in the Beach House- most of it is hers!
izations- primarily in the arts.
Libby Scott purchased this house in 2013
Why Libby Scott chose Cardiff by the Sea
The Cardiff Beach House is a perfect beach escape. Not only is it an exquisite custom home featuring all the conveniences of a 5 star resort- but is also located minutes from the beach, fabulous restaurants, bars and shopping.
What makes this house unique
Incredible ocean views. Yes- you can listen to the surf break while watching whales, dolphins and surfers and incredible sunsets.


text:
Low Rise High Density
Low Rise High Density examines a housing type celebrated in the 1960s and 70s, and what it means in the United States today. The exhibition presents original oral histories with project architects and global case studies from the last 50 years.
Forty years ago, low-rise, high-density housing offered a substitute for the high-rise model then dominating public housing in the United States. Dense enough to support public transportation, yet low enough to avoid dependence on elevators, the type attempts to bring together the benefits of urban and suburban living. Presenting architectural drawings, photographs, and oral histories with project architects, Low Rise High Density traces typology over time. The consideration of environmental and social ideas embedded in low-rise, high-density housing is as urgent now as it was when the typology was first developed. Today we can look at low-rise, high-density housing as an alternative to suburban sprawl.
Exhibition Opening
Event Details:
Thursday, April 25, 2013
The Center for Architecture
536 LaGuardia Place
New York, New York
- More information:


text:
Fry French Fries With Only One Spoon Of Oil
What if I told you that you could make the perfect French fries with only a spoonful of any oil? You'd probably tell me that I was crazy and that I should stop dreaming. Well, it's time to wake up, because the folks at Tefal have actually come up with a device that allows you to do just that. The ActiFry will allow you to prepare genuine fries with just one spoonful of oil! The patented technology circulates hot air around the fries, while the mixing paddle disperses the oil. The technique results in fries that are crispy on the outside and soft on the inside. Personally I think it sounds too good to be true, but you know I'd give it a try. Well maybe if it wasn't for the $300 price tag...
What do you think? Would you give it a try?
To check out a video of the ActiFry in action, read more
Source: Spluch
- Sriracha beer exists, y'all — Grub Street
- 3 no-fail tips for Thanksgiving success, from Amanda Hesser — Food52
- What does a perfectly portioned Thanksgiving plate look like? — POPSUGAR Fitness
- Jimmy Fallon on the pros and cons of Thanksgiving — Eater
- Thanksgiving classics, remixed — Snapguide
- This sweet potato casserole milkshake is all kinds of awesome — Tastemade


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Challenge level:
Can you help the children in Mrs Trimmer's class make different
shapes out of a loop of string?
You can make a calculator count for you by any number you choose.
You can count by ones to reach 24. You can count by twos to reach
24. What else can you count by to reach 24?
Can you place the numbers from 1 to 10 in the grid?
A game for 2 people using a pack of cards Turn over 2 cards and try
to make an odd number or a multiple of 3.
Can you find the chosen number from the grid using the clues?
Find the squares that Froggie skips onto to get to the pumpkin
patch. She starts on 3 and finishes on 30, but she lands only on a
square that has a number 3 more than the square she skips from.
These red, yellow and blue spinners were each spun 45 times in
total. Can you work out which numbers are on each spinner?
Investigate the different shaped bracelets you could make from 18 different spherical beads. How do they compare if you use 24 beads?
In this maze of hexagons, you start in the centre at 0. The next
hexagon must be a multiple of 2 and the next a multiple of 5. What
are the possible paths you could take?
Andrew decorated 20 biscuits to take to a party. He lined them up and put icing on every second biscuit and different decorations on other biscuits. How many biscuits weren't decorated?
Find the words hidden inside each of the circles by counting around
a certain number of spaces to find each letter in turn.
How can you use just one weighing to find out which box contains
the lighter ten coins out of the ten boxes?
Frances and Rishi were given a bag of lollies. They shared them out evenly and had one left over. How many lollies could there have been in the bag?
This article for teachers describes how number arrays can be a
useful reprentation for many number concepts.
Norrie sees two lights flash at the same time, then one of them
flashes every 4th second, and the other flashes every 5th second.
How many times do they flash together during a whole minute?
Pat counts her sweets in different groups and both times she has
some left over. How many sweets could she have had?
A game for 2 or more people. Starting with 100, subratct a number from 1 to 9 from the total. You score for making an odd number, a number ending in 0 or a multiple of 6.
Help share out the biscuits the children have made.
Can you order the digits from 1-6 to make a number which is
divisible by 6 so when the last digit is removed it becomes a
5-figure number divisible by 5, and so on?
If there is a ring of six chairs and thirty children must either
sit on a chair or stand behind one, how many children will be
behind each chair?
Use cubes to continue making the numbers from 7 to 20. Are they sticks, rectangles or squares?
Use this grid to shade the numbers in the way described. Which
numbers do you have left? Do you know what they are called?
Factor track is not a race but a game of skill. The idea is to go
round the track in as few moves as possible, keeping to the rules.
Look at the squares in this problem. What does the next square look
like? I draw a square with 81 little squares inside it. How long
and how wide is my square?
Four of these clues are needed to find the chosen number on this
grid and four are true but do nothing to help in finding the
number. Can you sort out the clues and find the number?
Becky created a number plumber which multiplies by 5 and subtracts
4. What do you notice about the numbers that it produces? Can you
explain your findings?
On a farm there were some hens and sheep. Altogether there were 8 heads and 22 feet. How many hens were there?
This package will help introduce children to, and encourage a deep
exploration of, multiples.
I am thinking of three sets of numbers less than 101. They are the
red set, the green set and the blue set. Can you find all the
numbers in the sets from these clues?
This activity focuses on doubling multiples of five.
I am thinking of three sets of numbers less than 101. Can you find
all the numbers in each set from these clues?
Can you complete this jigsaw of the multiplication square?
What is the lowest number which always leaves a remainder of 1 when
divided by each of the numbers from 2 to 10?
Imagine a wheel with different markings painted on it at regular
intervals. Can you predict the colour of the 18th mark? The 100th
Ben's class were making cutting up number tracks. First they
cut them into twos and added up the numbers on each piece. What
patterns could they see?
Are these domino games fair? Can you explain why or why not?
Investigate which numbers make these lights come on. What is the smallest number you can find that lights up all the lights?
Nearly all of us have made table patterns on hundred squares, that
is 10 by 10 grids. This problem looks at the patterns on
differently sized square grids.
Mr Gilderdale is playing a game with his class. What rule might he have chosen? How would you test your idea?
Look at three 'next door neighbours' amongst the counting numbers. Add them together. What do you notice?
Got It game for an adult and child. How can you play so that you know you will always win?
In a square in which the houses are evenly spaced, numbers 3 and 10
are opposite each other. What is the smallest and what is the
largest possible number of houses in the square?
A game that tests your understanding of remainders.
In this problem we are looking at sets of parallel sticks that
cross each other. What is the least number of crossings you can
make? And the greatest?
What do the numbers shaded in blue on this hundred square have in common? What do you notice about the pink numbers? How about the shaded numbers in the other squares?
If you have only four weights, where could you place them in order
to balance this equaliser?
Use the interactivity to sort these numbers into sets. Can you give
each set a name?
Yasmin and Zach have some bears to share. Which numbers of bears
can they share so that there are none left over?
Arrange the four number cards on the grid, according to the rules,
to make a diagonal, vertical or horizontal line.
A game in which players take it in turns to choose a number. Can you block your opponent?


text:
Kukla's Korner Hockey
Looking At NHL Records
by Paul on 08/10/07 at 11:40 AM ET
Comments (0)
from Alan Adams of Sportsnet,
The National Hockey League, meanwhile, has its share of records that will never be broken, along with a few that could be broken.
Take Glenn Hall's mark of 502 consecutive starts in net. Not even New Jersey workhorse Martin Brodeur can slip on a Superman costume and better this accomplishment.
How about Teemu Selanne's 76 goals as a rookie with the Winnipeg Jets in 1992-93? Unless the NHL makes nets as big as soccer nets, you have to think Selanne will be the perennial benchmark for rookies to shoot for.
read on about records that may or may not be broken…
Filed in: NHL Talk, | KK Hockey | Permalink
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Das Schweigen von Ralf Dziminski wird überbewertet
ralf dziminski
livejournal userinfo
journal archive
(no subject)
[May. 27th, 2018|
11:21 pm
dzima's noticeboard
Leave a comment.
(you can write anything you feel like here)
51 comments
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(no subject)
[Sep. 4th, 2010|
03:25 pm
Good morning.
Just to let you know, I'm more active on tumblr and flickr these days, that is to say, I take pictures of myself which are actually accepted as academic work, then I post them online:
Dzima's Tumblr
Dzima's Flickr
Dzima's Twitter
I'll be surprised if anyone comments here let alone reads this.
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Leave a comment
I'd have made this announcement on tumblr if I knew how to use that site
[Jan. 22nd, 2010|
06:32 pm
I'm back in Aus.
After seeing all the nuclear destruction and fallout caused by the latest financial crisis, I wish that all the children will sing 'Brand New Day' so that we can make the world a better place in Mad Max 4.
By the way, I'm also back in university. Because if you haven't noticed yet I'll be forever 18 in my head.
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(no subject)
[May. 23rd, 2009|
07:33 am
For those of you out of the loop, I've been spending sometime in South America with my adorable family as of lately. In
Val Verde
to be precise (the same country whose dictator Arnold killed in Commando and where the Predator attacked in his first movie. Also, it's where Sly Stallone is shooting 'The Expendables').
Life is great; if you earn $10 a day here, you can live like a king. My palate is being constantly delighted as well; the locals have come up with hundreds of different ways to make a meal with white flour, sugar and/or meat
And to disappoint all my fans, I also hardly own any musical or photographic gear these days. I'm just trying to make to world a better place without my "art".
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(no subject)
[Mar. 5th, 2009|
09:32 pm
Just writing this short note to tell people who haven't visited
's website, go do it now!
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(no subject)
[Feb. 23rd, 2009|
11:21 pm
I'll fly off tomorrow allegedly but I might be back sooner than you expect, just like the next sequel in the Die Hard franchise.
Here's me, wearing the famous Meta t-shirt. Please help Meta's trust fund by buying this t-shirt from Alin at
By the way, here's a pixelated tour of Alin's new place.
Alin's place video
He's already planning a new exhibition at there to be curated by The Edge, featuring photos by Pete Toms, a sound installation digitally manipulating Pavarotti's voice samples by Brian Eno and paintings by Nelson Mandela, sponsored by Amnesty International. Coffee at opening party provided by yours truly.
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(no subject)
[Feb. 20th, 2009|
11:01 pm
While I still can't find a job, I've decided to launch myself into some entrepreneurial joint ventures in the meantime, specially in the fitness business.
I'm proudly announcing our latest release, the Doraemon Barbell.
If you wanted to do your own squats, deadlifts, bench presses and power cleans at home but don't have enough space for a power rack, here is the all-in-one solution. Weighing 45kg, it provides with enough resistance for the ultimate pump.
In case you wondered how Steven Seagal got his amazing physique in the movies Fire Down Below and Under Siege II: Dark Territory, all he did was to exercise with our very own Doraemon Barbell. Don't go out believing any bogus fitness programs; all you'll ever need is a Doraemon Barbell.
Here's a demonstration video.
Yours for only U$149.99 including shipping worldwide.
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[Feb. 12th, 2009|
10:54 am
Looks like I'll be back in Australia very soon. I'm so excited about it that I can't stop smiling, like this:
I'll be looking forward to restart my career as an assistant to the 2nd in charge duty manager at Hungry Jack's/Burger King and being a homeless man, sleeping at Hyde Park with all my best mates: possums, ibises and mosquitoes. I'm not exaggerating.
On less gloomy news, I went to Yokohama Chinatown for the second time ever to apply for a toilet cleaner job. I didn't get it because I didn't have enough work experience and the employer required a university degree in toilet cleaning. Plus the current recession is making people want to save on detergent and not to clean their toilets anymore. Anyway, here are some pictures and videos of Yokohama Chinatown:
It's very touristy, like San Francisco Chinatown. My favourite shop was the one that sold Bruce Lee jumpsuits for kids and babies:
Yokohama Chinatown #1
Yokohama Chinatown #2
Yokohama Chinatown #3
Yokohama Chinatown #4
Today I'm applying for a job to be a window cleaner/windowlicker at the 103rd floor of Roppongi Hills, so may you and Richard D. James wish me good luck. Hopefully they won't require work experience or university degree on window cleaning.
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Kanto Pilgrimage: (H)Iroshima, mon amour
[Jan. 24th, 2009|
11:10 pm
Recently, I got this job that was meant to last for 3 months but which I ended up quitting after one week. It mostly comprised of going to the snowy mountains near Hiroshima, living surrounded by snow and pine trees in complete isolation from the outside world while looking for humans that were infected by a never seen alien mutating shape-shifting species. But that was just my imagination. I quit before I ended up running with an axe after completely normal human beings and ended up too tired of doing heavy workouts in the snow. (There's your next summer blockbuster plot summary: a cross between The Thing, The Shining, Rocky IV and Total Recall).
Here's my failed attempt at snowboarding.
My only friends there were foxes and wild boars. We had a few beers together.
I visited Hiroshima as well. No insult but there's not much to see apart from the obvious A-bomb destroyed sites and related memorials.
The only remaining building from the bombing
How to dismantle Bono with an Atomic Bomb
No matter what Momus wants you to believe in, Japanese people love America more than they even love themselves so here are the stars and stripes standing proudly a few meters away from where the bomb was originally dropped. No joke.
I also tried some local cuisine: Hiroshima style Okonomiyaki. If you had Yakisoba, it's the same thing but with the noodles on top of the vegetables. I'll stick with
Osaka style Okonomiyaki
from now on.
According to our sorely missed friend Sparklig Beatnic, they were burning last year's protective amulets here at Gokoku Shrine.
It was very warm though so hung out there for while. Here are a few vids of the bonfire:
Gokoku #1
Gokoku #2
Gokoku #3
Also, Hiroshima Castle wasn't that interesting but the ducks in the moat were amusing.
I tried to go to the Contemporary Art Museum but it was closed but apparently it's not very interesting anyway. Then I came back to Tokyo by bus, 12 hour trip, very much looking forward to have a break from snow and alien creatures who don't pay you a proper wage.
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[Dec. 6th, 2008|
06:27 pm
And now to break the silence and for some good news...
I have found a new full time job. All I can say so far is that it has something to do with this:
Also, I'll be starring in an upcoming Beat Takeshi (or Takeshi Kitano) movie... well, almost.
Stay tuned.
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text: Arthritis Research & Therapy - Latest Articles http://arthritis-research.com/ The latest research articles published by Arthritis Research & Therapy 2014-11-22T01:35:05Z Use of next-generation DNA sequencing to analyze genetic variants in rheumatic disease Next-generation DNA sequencing has revolutionized the field of genetics and genomics, providing researchers with the tools to efficiently identify novel rare and low frequency risk variants, which was not practical with previously available methodologies. These methods allow for the sequence capture of a specific locus or small genetic region all the way up to the entire six billion base pairs of the diploid human genome.Rheumatic diseases are a huge burden on the US population, affecting more than 46 million Americans. Those afflicted suffer from one or more of the more than 100 diseases characterized by inflammation and loss of function, mainly of the joints, tendons, ligaments, bones, and muscles. While genetics studies of many of these diseases (for example, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease) have had major successes in defining their genetic architecture, causal alleles and rare variants have still been elusive. This review describes the current high-throughput DNA sequencing methodologies commercially available and their application to rheumatic diseases in both case–control as well as family-based studies. http://arthritis-research.com/content/16/6/490 Graham Wiley Jennifer Kelly Patrick Gaffney Arthritis Research & Therapy 2014, null:490 2014-11-22T01:35:05Z doi:10.1186/s13075-014-0490-4 /content/figures/s13075-014-0490-4-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 490 2014-11-22T01:35:05Z XML The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology The peripheral nervous system is critically involved in bone metabolism, osteogenesis, and bone remodeling. Nerve fibers of sympathetic and sensory origin innervate synovial tissue and subchondral bone of diathrodial joints. They modulate vascularization and matrix differentiation during endochondral ossification in embryonic limb development, indicating a distinct role in skeletal growth and limb regeneration processes. In pathophysiological situations, the innervation pattern of sympathetic and sensory nerve fibers is altered in adult joint tissues and bone. Various resident cell types of the musculoskeletal system express receptors for sensory and sympathetic neurotransmitters. Osteoblasts, osteoclasts, mesenchymal stem cells, synovial fibroblasts, and different types of chondrocytes produce distinct subtypes of adrenoceptors, receptors for vasointestinal peptide, for substance P and calcitonin gene-related peptide. Many of these cells even synthesize neuropeptides such as substance P and calcitonin gene-related peptide and are positive for tyrosine-hydroxylase, the rate-limiting enzyme for biosynthesis of catecholamines. Sensory and sympathetic neurotransmitters modulate osteo-chondrogenic differentiation of mesenchymal progenitor cells during endochondral ossification in limb development. In adults, sensory and sympathetic neurotransmitters are critical for bone regeneration after fracture and are involved in the pathology of inflammatory diseases as rheumatoid arthritis which manifests mainly in joints. Possibly, they might also play a role in pathogenesis of degenerative joint disorders, such as osteoarthritis. All together, accumulating data imply that sensory and sympathetic neurotransmitters have crucial trophic effects which are critical for proper limb formation during embryonic skeletal growth. In adults, they modulate bone regeneration, bone remodeling, and articular cartilage homeostasis in addition to their classic neurological actions. http://arthritis-research.com/content/16/6/485 Susanne Grässel Arthritis Research & Therapy 2014, null:485 2014-11-22T01:24:11Z doi:10.1186/s13075-014-0485-1 /content/figures/s13075-014-0485-1-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 485 2014-11-22T01:24:11Z XML Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case¿control and cohort study IntroductionRepetitive episodes of ischemia and reperfusion (I/R) are a cardinal feature of the pathogenesis of systemic sclerosis (SSc), which precedes tissue fibrosis. The complement system is a key mediator of tissue damage after I/R, primarily by activation of the lectin pathway. This study investigated whether serum levels and polymorphisms of mannose-binding lectin (MBL) and ficolin-2 (FCN2), two pattern recognition receptors of the lectin pathway, are associated with the predisposition to, and clinical features of SSc. Methods: A case?control study was undertaken involving 90 patients with SSc from a single SSc outpatient clinic and 90 age- and sex-matched blood donors. MBL and FCN2 levels and polymorphisms were measured in both groups, and in cases correlated with clinical data. Results: MBL levels and genotypes were equally distributed in cases and controls while there were some significant differences in FCN2 polymorphisms. Median MBL levels were higher in SSc cases with diffuse disease compared with controls (2.6 versus 1.0 ?g/ml, P <0.001).In some cases, higher MBL levels were associated with the presence of clinical findings associated with vascular dysfunction and local tissue damage (digital ulcers, calcinosis and pitting). Moreover, MBL levels were associated with fibrotic disease manifestations as evidenced by the presence of diffuse disease (median 2.6 versus 0.8 ?g/ml, P =0.002), the modified Rodnan skin score (r =0.39, P <0.001), and interstitial lung disease as measured by forced vital capacity (r?=??0.33, P =0.001). Importantly, MBL levels also correlated with the SSc Health Assessment Questionnaire scores (r =0.33, P =0.002). The results for FCN2 levels were less striking. Phenotypic MBL results were largely confirmed by analysis of MBL polymorphisms. MBL levels were not associated with the presence of autoantibodies or hypocomplementaemia. Conclusions: Overall, predisposition to SSc was not influenced by the lectin pathway of complement in our matched case?control study. However, our preliminary data suggest that MBL, and to a lesser extent FCN2 may modulate disease manifestations of SSc, particularly in diffuse cutaneous disease. http://arthritis-research.com/content/16/6/480 Michael Osthoff Gene-Siew Ngian Melinda Dean Mandana Nikpour Wendy Stevens Susanna Proudman Damon Eisen Joanne Sahhar Arthritis Research & Therapy 2014, null:480 2014-11-18T12:00:00Z doi:10.1186/s13075-014-0480-6 /content/figures/s13075-014-0480-6-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 480 2014-11-18T12:00:00Z PDF Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis IntroductionActivated platelets exert a proinflammatory action that can be largely ascribed to their ability to interact with monocytes. However, the mechanisms that promote dynamic changes in monocyte subsets in rheumatoid arthritis (RA) have not been clearly identified. The aim of this study was to determine whether platelet activation and the consequent formation of monocyte-platelet aggregates (MPA) might induce a proinflammatory phenotype in circulating monocytes in RA. Methods: The surface phenotype of platelets and the frequencies of monocyte subpopulations in the peripheral blood of RA patients were determined using flow cytometry. Platelets were sorted and co-cultured with monocytes. In addition, monocyte activation was assessed by measuring the nuclear factor ?B (NF-?B) pathway. The disease activity was evaluated using the 28-joint disease activity score. Results: Platelet activation, circulating intermediate monocytes (Mon2) and MPA formation were significantly elevated in RA, especially in those with active disease status. Furthermore, Mon2 monocytes showed higher CD147 expression and responded to direct cell contact with activated platelets with higher cytokine production and matrix metallopeptidase 9 (MMP-9) secretion, which increased the expression of CD147. After the addition of specific antibodies for CD147, those effects were abolished. Furthermore, the NF-?B?driven inflammatory pathway may be involved in this process. Conclusion: These findings indicate an important role of platelet activation and the consequent formation of MPA in the generation of the proinflammatory cytokine milieu and for the promotion and maintenance of the pathogenically relevant Mon2 monocyte compartment in RA, which is likely to play an important role in the pathogenesis of autoimmunity. http://arthritis-research.com/content/16/6/478 Meng-yao Rong Cong-hua Wang Zhen-biao Wu Wen Zeng Zhao-hui Zheng Qing Han Jun-feng Jia Xue-yi Li Ping Zhu Arthritis Research & Therapy 2014, null:478 2014-11-18T12:00:00Z doi:10.1186/s13075-014-0478-0 /content/figures/s13075-014-0478-0-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 478 2014-11-18T12:00:00Z PDF Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis IntroductionRecent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo. Since the systemic use of rapamycin is associated with numerous side effects, the goal of the current study was to examine the beneficial effect of local intra-articular injection of rapamycin in a murine model of OA and to elucidate the mechanism of action of rapamycin on articular cartilage. Methods: Destabilization of the medial meniscus (DMM) was performed on 10-week-old male mice to induce OA. Intra-articular injections of 10??l of rapamycin (10??M) were administered twice weekly for 8?weeks. Articular cartilage damage was analyzed by histology using a semi-quantitative scoring system at 8 and 12?weeks after surgery. Mammalian target of rapamycin (mTOR), light chain 3 (LC3), vascular endothelial growth factor (VEGF), collagen, type X alpha 1 (COL10A1), and matrix metallopeptidase 13 (MMP13) expressions were analyzed by immunohistochemistry. VEGF, COL10A1, and MMP13 expressions were further examined via quantitative RT-PCR (qPCR). Results: Intra-articular injection of rapamycin significantly reduced the severity of articular cartilage degradation at 8 and 12?weeks after DMM surgery. A reduction in mTOR expression and the activation of LC3 (an autophagy marker) in the chondrocytes was observed in the rapamycin treated mice. Rapamycin treatment also reduced VEGF, COL10A1, and MMP13 expressions at 8 and 12?weeks after DMM surgery. Conclusion: These results demonstrate that the intra-articular injection of rapamycin could reduce mTOR expression, leading to a delay in articular cartilage degradation in our OA murine model. Our observations suggest that local intra-articular injection of rapamycin could represent a potential therapeutic approach to prevent OA. http://arthritis-research.com/content/16/6/482 Koji Takayama Yohei Kawakami Makoto Kobayashi Nick Greco James Cummins Takehiko Matsushita Ryosuke Kuroda Masahiro Kurosaka Freddie Fu Johnny Huard Arthritis Research & Therapy 2014, null:482 2014-11-17T12:00:00Z doi:10.1186/s13075-014-0482-4 /content/figures/s13075-014-0482-4-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 482 2014-11-17T12:00:00Z PDF Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis IntroductionProgression of arterial involvement is often observed in patients with Takayasu arteritis (TA) thought to be in remission. This reflects the failure of currently used biomarkers and activity criteria to detect smouldering inflammation occurring within arterial wall. Pentraxin-3 (PTX3) is a soluble pattern recognition receptor produced at sites of inflammation and could reveal systemic as well as localized inflammatory processes. We verified whether the blood concentrations of PTX3 and of C-reactive protein (CRP) in patients with Takayasu arteritis (TA) might reflect vascular wall involvement, as assessed by signal enhancement after contrast media administration, and the progression of arterial involvement. Methods: A cross-sectional single-centre study was carried out on 42 patients with TA that comprised assessment of PTX3, of CRP and erythrocyte sedimentation velocity (ESR). In total, 20 healthy controls and 20 patients with Systemic Lupus Erythematous (SLE) served as controls. Vascular imaging was carried out by magnetic resonance angiography, doppler ultrasonography and computed tomography angiography. Results: Patients with TA and SLE had higher plasmatic PTX3 and CRP concentrations than healthy controls (P?=?0.009 and 0.017, respectively). PTX3 levels did not correlate with those of CRP. Patients with active systemic TA had significantly higher concentrations of CRP but similar levels of PTX3 than patients with quiescent disease. In contrast, patients with vascular inflammation detectable at imaging had higher PTX3 concentrations (P?=?0.016) than those in which vessel inflammation was not evident, while CRP levels were similar. The concentration of PTX3 but not that of CRP was significantly higher in TA patients with worsening arterial lesions that were not receiving antagonists of tumor necrosis factor-? or interleukin-6. Conclusions: Arterial inflammation and progression of vascular involvement influence plasma PTX3 levels in TA, while levels of CRP accurately reflect the burden of systemic inflammation. These results support the contention that PTX3 reflects different aspects of inflammation than CRP and might represent a biomarker of actual arteritis in TA. http://arthritis-research.com/content/16/6/479 Enrico Tombetti Maria Di Chio Silvia Sartorelli Maurizio Papa Annalaura Salerno Barbara Bottazzi Enrica Bozzolo Marta Greco Patrizia Rovere-Querini Elena Baldissera Alessandro Del Maschio Alberto Mantovani Francesco De Cobelli Maria Sabbadini Angelo Manfredi Arthritis Research & Therapy 2014, null:479 2014-11-14T12:00:00Z doi:10.1186/s13075-014-0479-z /content/figures/s13075-014-0479-z-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 479 2014-11-14T12:00:00Z PDF Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease associated with a break in self-tolerance reflected by a production of antinuclear autoantibodies. Since autoantibody production can be activated via nucleic acid Toll-like receptor 9 (TLR9), the respective pathway has been implicated in the development of SLE and pathogenic B cell responses. However, the response of B cells from SLE patients to TLR9 stimulation remains incompletely characterized. Methods: In the current study, the response of B cells from SLE patients and healthy donors upon TLR9 stimulation was analyzed in terms of proliferation and cytokine production and correlated with the lupus disease activity and anti-dsDNA titers. Results: B cells from SLE patients showed a reduced response to TLR9 agonist compared to B cells from healthy donors in terms of proliferation and activation. B cells from SLE patients with higher disease activity produced less interleukin (IL)-6, IL-10, vascular endothelial growth factor, and IL-1ra than B cells from healthy donors. Further analyses revealed an inverse correlation of cytokines produced by TLR9-stimulated B cells with lupus disease activity and anti-dsDNA titer, respectively. Conclusion: The capacity of B cells from lupus patients to produce cytokines upon TLR9 engagement becomes less efficient with increasing disease activity, suggesting that they either enter an exhausted state or become tolerant to TLR stimulation for cytokine production when disease worsens. http://arthritis-research.com/content/16/6/477 Julia Sieber Capucine Daridon Sarah Fleischer Vanessa Fleischer Falk Hiepe Tobias Alexander Guido Heine Gerd Burmester Simon Fillatreau Thomas Dörner Arthritis Research & Therapy 2014, null:477 2014-11-11T12:00:00Z doi:10.1186/s13075-014-0477-1 /content/figures/s13075-014-0477-1-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 477 2014-11-11T12:00:00Z PDF The metastasis promoting protein S100A4 levels associate with disease activity rather than cancer development in patients with idiopathic inflammatory myopathies IntroductionThe aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. Methods: Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy controls. The associations between S100A4 levels, inflammation, disease activity, muscle strength and cancer development were evaluated. Results: All myositis patients had significantly higher serum levels of S100A4 protein compared to healthy controls (median (IQR): 31.5 (17.4 to 59.5) versus 23.8 (14.5 to 33.7) ng/ml, P <0.05). In patients with PM, serum levels of S100A4 protein were significantly higher than in healthy controls (41.6 (24.2 to 123.1) versus 23.8 (14.5 to 33.7) ng/ml; P <0.001) as well as in patients with DM (26.7 (11.3 to 47.5) ng/ml; P <0.05). The levels of S100A4 were comparable between myositis with and without cancer. In all myositis patients, serum S100A4 levels correlated with MYOsitis disease ACTivity assessment (MYOACT) score (r = 0.34; P = 0.001), constitutional (r = 0.30; P = 0.003), pulmonary (r = 0.43; P = 0.0001) and extramuscular disease activity (r = 0.36; P = 0.0001), as well as with creatine phosphokinase (r = 0.27; P = 0.015) and lactate dehydrogenase (r = 0.37; P = 0.002) or c-reactive protein (CRP) levels (r = 0.24; P = 0.038). Multiple regression analysis showed significant association between S100A4 serum levels and extramuscular disease activity (β = 0.552; P = 0.002) in PM patients and with MYOACT (β = 0.557; P = 0.003) and CRP levels (β = 0.391; P = 0.029) in DM patients. Conclusions: Circulating levels of S100A4 are elevated in patients with myositis and associate with several disease activity parameters, particularly with extramuscular components. No relation between S100A4 levels and presence of cancer associated myositis was found. http://arthritis-research.com/content/16/5/468 Lenka Ple¿tilová He¿man Mann Lucie Andrés Cerezo Ond¿ej Pecha Ji¿í Vencovský Ladislav ¿enolt Arthritis Research & Therapy 2014, null:468 2014-10-31T12:00:00Z doi:10.1186/s13075-014-0468-2 /content/figures/s13075-014-0468-2-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 468 2014-10-31T12:00:00Z XML Ultrasound composite scores for the assessment of inflammatory and structural pathologies in Psoriatic Arthritis (PsASon-Score) IntroductionThis study was performed to develop ultrasound composite scores for the assessment of inflammatory and structural lesions in Psoriatic Arthritis (PsA). Methods: We performed a prospective study on 83 PsA patients undergoing two study visits scheduled 6?months apart. B-mode and Power Doppler (PD) findings were semi-quantitatively scored at 68 joints (evaluating synovia, perisynovial tissue, tendons and bone) and 14 entheses. We constructed bilateral and unilateral (focusing the dominant site) ultrasound composite scores selecting relevant sites by a hierarchical approach. We tested convergent construct validity, reliability and feasibility of inflammatory and structural elements of the scores as well as sensitivity to change for inflammatory items. Results: The bilateral score (termed PsASon22) included 22 joints (6 metacarpophalangeal joints (MCPs), 4 proximal interphalangeal joints (PIPs) of hands (H-PIPs), 2 metatarsophalangeal joints (MTPs), 4 distal interphalangeal joints (DIPs) of hands (H-DIPs), 2 DIPs of feet (F-DIPs), 4 large joints) and 4 entheses (bilateral assessment of lateral epicondyle and distal patellar tendon). The unilateral score (PsASon13) compromised 13 joints (2 MCPs, 3?H-PIPs, 1 PIP of feet (F-PIP), 2 MTPs, 1?H-DIP and 2?F-DIPs and 2 large joints) and 2 entheses (unilateral lateral epicondyle and distal patellar tendon). Both composite scores revealed a moderate to high sensitivity (bilateral composite score 43% to 100%, unilateral 36% to 100%) to detect inflammatory and structural lesions compared to the 68-joint/14-entheses score. The inflammatory and structural components of the composite scores correlated weakly with clinical markers of disease activity (corrcoeffs 0 to 0.40) and the health assessment questionnaire (HAQ, corrcoeffs 0 to 0.39), respectively. Patients with active disease achieving remission at follow-up yielded greater reductions of ultrasound inflammatory scores than those with stable clinical activity (Cohen?s d effect size ranging from 0 to 0.79). Inter-rater reliability of bi- and unilateral composite scores was moderate to good with ICCs ranging from 0.42 to 0.96 and from 0.36 to 0.71, respectively for inflammatory and structural sub-scores. The PsASon22 and PsASon13 required 16 to 26 and 9 to 13?minutes, respectively to be completed. Conclusion: Both new PsA ultrasound composite scores (PsASon22 and PsASon13) revealed sufficient convergent construct validity, sensitivity to change, reliability and feasibility. http://arthritis-research.com/content/16/5/476 Anja Ficjan Rusmir Husic Judith Gretler Angelika Lackner Winfried Graninger Marwin Gutierrez Christina Duftner Josef Hermann Christian Dejaco Arthritis Research & Therapy 2014, null:476 2014-10-31T00:00:00Z doi:10.1186/s13075-014-0476-2 /content/figures/s13075-014-0476-2-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 476 2014-10-31T00:00:00Z PDF CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients IntroductionSingle nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to pro-inflammatory stimuli. Previous reports suggest these effects may have an impact on clinical decision-making based on CRP, for example DAS28. We aimed to investigate the possible association between 7 CRP SNPs, their haplotypes, and the serum level of CRP as well as the DAS28 score in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment. Methods: Overall, 315 disease-modifying anti-rheumatic drugs and steroid na?ve RA patients with disease duration <6?months were included from two randomized controlled trials (the CIMESTRA and OPERA trials). Seven CRP SNPs were investigated: rs11265257, rs1130864, rs1205, rs1800947, rs2808632, rs3093077 and rs876538. The genotype and haplotype associations to CRP and DAS28 levels were evaluated using linear regression analysis adjusted for age, sex and treatment. Results: The minor allele of rs1205 C?>?T was associated with decreased CRP levels at baseline (P =0.03), with the TT genotype having a 50% reduction in CRP from 16.7 to 8.4?mg/L (P =0.005) compared to homozygosity of the major allele, but no association was observed at year one (P =0.38). The common H2 haplotype, characterized by the T allele of rs1205, was associated with a 26% reduction in CRP at baseline (P =0.043), although no effect was observed at year one (P =0.466). No other SNP or haplotype was associated with CRP at baseline or year one (P ?0.09). We observed no associations between SNPs or haplotypes and DAS28 scores at baseline or year one (P ?0.10). Conclusion: CRP genotype and haplotype were only marginally associated with serum CRP levels and without any association to the DAS28 score. This study shows that DAS28, the core parameter for inflammatory activity in RA, can be used for clinical decision-making without adjustment for CRP gene variants.Trial registrationThe OPERA study is registered at clinicaltrials.gov (NCT00660647). The Cimestra study is not listed in a clinical trials registry due to inclusion of patients between October 1999 and October 2002. http://arthritis-research.com/content/16/5/475 Christian Ammitzbøll Rudi Steffensen Martin Bøgsted Kim Hørslev-Petersen Merete Hetland Peter Junker Julia Johansen Jan Pødenphant Mikkel Østergaard Torkell Ellingsen Kristian Stengaard-Pedersen Arthritis Research & Therapy 2014, null:475 2014-10-31T00:00:00Z doi:10.1186/s13075-014-0475-3 /content/figures/s13075-014-0475-3-toc.gif Arthritis Research & Therapy 1478-6354 ${item.volume} 475 2014-10-31T00:00:00Z PDF


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text: Comments on: Keith Tkachuk Suspended By St. Louis Blues!!!! http://hockeytraderumors.com/keith-tkachuk-suspended-by-st-louis-blues/ NHL - Hockey Trade Rumors, providing NHL Hockey Trade Rumors since 1996 Thu, 27 Nov 2014 19:15:11 +0000 hourly 1 By: GreatWhiteNorth http://hockeytraderumors.com/keith-tkachuk-suspended-by-st-louis-blues/comment-page-1/#comment-126333 Mon, 19 Sep 2005 16:04:09 +0000 http://localhost/wordpress24/?p=10600#comment-126333 I've heard that he was over 300lbs during a golf tournament during the lockout. He doesn't really stay in shape outside of hockey. ]]> By: wingerxxx http://hockeytraderumors.com/keith-tkachuk-suspended-by-st-louis-blues/comment-page-1/#comment-126332 Mon, 19 Sep 2005 14:10:27 +0000 http://localhost/wordpress24/?p=10600#comment-126332 That sounds a little better. There is just no way I could imagine Tkachuk pushing 300 lbs. ]]> By: distance7 http://hockeytraderumors.com/keith-tkachuk-suspended-by-st-louis-blues/comment-page-1/#comment-126331 Mon, 19 Sep 2005 14:05:36 +0000 http://localhost/wordpress24/?p=10600#comment-126331 Well, it isn't a good explanation, but the Blues' owner apparently didn't want to have to buy out their contract and then pay other people to come in. Since he's trying to sell them and it'd be cheaper just to have them on instead of handing out large sums of money to these people. That's what I've heard, at least. ]]> ructation


text:
The noise of loads of people in the same room typing on computers
Keith: I Couldn't hear anything because of that keyboard symphony
by The Muffin Bear November 06, 2010
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