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1,001 Things It Means to Be a Dad: Some Assembly Required
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|Format: Paperback
Number of Pages: 304
Vendor: Thomas Nelson
Publication Date: 2008
|Dimensions: 5.50 X 4.50 (inches)
Availability: In Stock
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Publisher's Description
D-A-D. How can three letters mean a 1001 things?!
Harry H. Harrison Jr.'s latest dose of his trademark wit and wisdom pays tribute and provides insight to dads from all walks of life. From new dads, single dads, dads of adult kids and more, 1001 Things it Means to be a Dad is a topic we can all appreciate, especially when there's "some assembly required!" With two million books in the market, no one knows how to deliver simple, powerful insights like Harry.
Author Bio
Harry H. Harrison, Jr. is a nationally acclaimed author appearing on the NY Times and Booksense lists of best-selling non-fiction trade paperback and parenting books. He has over 1.8 million books in print featuring titles such as Father to Son, Father to Daughter, Life Lessons on Raising a Boy, Mother to Daughter, plus five titles in his 1001 Things series. He's been interviewed on 22 television programs and featured on over 50 local and syndicated radio programs coast to coast. His books are sold throughout Western Europe, Norway, South America, and the Far East. He and his wife, Melissa, have two boys.
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Home » Opinion » Editorials
SNHU's revolution: A bold experiment
A traditional college degree is based on spending two or four years in classes, then passing exams that produce transcripts full of letter grades. The costs at SNHU are around $50,000 for a two-year degree, $110,000 for a four-year degree. With the approval of the university's new competency-based model, students will have the opportunity to earn a two-year degree for about $5,000. Instead of tallying their classroom instruction time, the university will assess the students' knowledge and skills.
"For the first time in the history of American higher education, federal dollars will support a degree path based on what you have learned, not how long you have sat in a chair," SNHU President Paul Leblanc told this newspaper.
The university is calling this initiative the College for America. Available only through participating employers, eventually it will be opened to the public.
This is not New Hampshire's first foray into competency-based education. During Gov. Craig Benson's term, state Board of Education Chairman Fred Bramante pushed hard to have competency-based education and real-world learning introduced into the public school system. He succeeded, which allowed some very innovative experiments. But the public K-12 education system being what it is, these changes have been slow to spread.
Higher education is a different beast. It is highly competitive. Good (and bad) ideas can spread quickly. Already administrators at other colleges and universities are considering following SNHU's lead. It is too early to call this a revolution, but Leblanc's experiment definitely is noteworthy.
"What higher education has historically been able to do with great precision is tell the world how long a student spent on a topic, not what they have actually learned," Leblanc said earlier this month. "So when an employer gets a transcript in front of them, and sees the student got a 'B,' all that tells them is that the student did better than a student who got a 'C,' but they don't know what the student actually learned. When they get a transcript from CFA, they will see 120 competencies that define very precisely what a student knows."
The appeal for employers is obvious. Students should be attracted by the dramatically lower prices and the opportunity to go at their own pace. Is this the long-sought answer to the ever-rising price of higher education? It is far too early to know. But it is an experiment with promise, and Leblanc deserves credit for conducting it.
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subset: commoncrawl


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Josh Donaldson
A's Donaldson Turns Flub Into Fantastic Play
On Sunday he blasted a walk-off homer in extra innings. He followed that up Monday night with a pretty slick play against Angels Catcher Chris Ianneta.
Donaldson Gets Career-High 5 Hits, A's Defeat White Sox In Rout
Josh Donaldson had a career-high five hits while driving in four runs, helping Jon Lester and the Oakland Athletics beat the Chicago White Sox 11-2 on Tuesday night
Samardzija Snaps Skid, A's Defeat Astros
Jeff Samardzija pitched eight solid innings and Josh Donaldson drove in three runs to lead the Oakland Athletics over the Houston Astros 8-2 Monday night.
Lester Sharp, A's Snap Royals Winning Streak
Jon Lester pitched six strong innings and Josh Donaldson homered twice and drove in four runs as the Oakland Athletics beat Kansas City 11-3 Tuesday night, snapping the Royals' eight-game winning streak.
A's All-Stars Play Role In Leading American League Over National League
On a summer evening filled with reminders of generational change, the AL kept up nearly two decades of dominance by beating the National League 5-3 in the All-Star game Tuesday for its 13th win in 17 years.
Back To Back: A's Cespedes Wins Second Straight Home Run Derby
Oakland's Yoenis Cespedes became the first repeat winner of the All-Star home run derby in 15 years, powering his way past Cincinnati's Todd Frazier by a whopping 9-1 in the final round Monday night.
Daily Madden: A's In Center Stage At Home Run Derby Circus
A's All-Star Josh Donaldson will participate. Should A's manager Bob Melvin be concerned with Donaldson's statement that he'll try to hit one out of the stadium?
Kazmir Sharp, A's Beat Giants In Finale Of Bay Bridge Series
All-Star Scott Kazmir struck out nine in seven scoreless innings to help the Oakland Athletics win the annual Bay Bridge series by beating the San Francisco Giants 6-1 on Thursday.
Daily Madden: All-Star Selections Honor The A's
Six players from the Oakland A's have been selected for the All-Star game, the most since 1975.
A's Lead Major League Baseball With 6 All-Star Selections, Giants Earn 2
The team with baseball's best record also boasts the most All-Star selections for next week's midsummer classic. The Oakland A's will send six of their starters to the game at Target Field in Minnesota on July 15.


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- Publisher: Interplay
- Release Date: Jun 13, 2001
- Critic Score
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Ultimately, a gap-filled and very linear storyline, a lack of any sort of multiplayer or joystick support, and the relative ease of mission completion undermine any real value here for the gamer.
User Score
Generally favorable reviews- based on 22 Ratings
User score distribution:
Positive: 4 out of 4
Mixed: 0 out of 4
Negative: 0 out of 4
Nov 19, 2012It's been over a decade since this game was released. I thank my dad for buying me this game. The game was well presented. The story was very powerful, and the narrator had you at the edge of your seat. As for graphics, they will obviously be ugly compared to those of more modern games, but, hey, this game was made in 2001, so give it a break. It was great at the time. Now for the gameplay. What a wonderful combination of real-time strategy and third-person shooter elements! Yes, it has the action, but you really need think, and start being strategic. And I love the resource management. The sound and music were excellent as well. What pains me is that there was no multiplayer. If it had multiplayer, then it would be a great game perfected. Unfortunately, the game only has a story mode, so once you beat the game, that's it. But it takes about 20-30 hours to complete, and a second playthrough is worth it, so that's like 40-60 hours. In conclusion, this is the best game nobody plays. I hope one day, someone will remake this game, solve all its issues and I'll buy it on day one.… Full Review »
JenkinSDec 22, 2009Hostile Waters was very far beyond it's time when it was released, I still could not find anything comparable in the game world today, with it's uniformly created games always basing on Action, Horror and the graphic improvements of their predecessors. I still play it, I'm still impressed from it's depth. When I reached the end I was empty. Rage should have sold the license to anyone, who was able to create good remakes or sequels.… Full Review »
[Anonymous]Oct 26, 2005Solid hybrid strategy/action game. Pretty unique, I really liked it.


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Listeners with a taste for sultry R&B slow jams are likely aware that, in addition to being fun to listen to, the songs are often designed to serve a very practical purpose: to smooth out lovers' quarrels by expressing those feelings that can't be put into words (particularly on the male side of the equation). Fresh off a move to new label home Asylum (through Notifi Records), industry veteran Ginuwine knows this better than anyone, and on the lead single off his forthcoming sixth LP he speaks for anyone desperate for one Last Chance with a special someone. Officially chosen for promotion after being leaked to the 'net in early January, the record finds Ginuwine pouring his heart out over a sweeping, piano-driven instrumental by Bryan-Michael Cox, expressing just how ready he is to make things right with a few well-chosen metaphors ("If I've only got one shot to win you, call me Jordan, fourth quarter, in '92."). If you're yearning for more of 'wine's time-tested R&B stylings, pick up a copy of A Man's Thoughts, his first album in nearly four years, this June.
Written by richard on 03/29/09
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Tennessee State Parks Vacation Packages
Thank you to all our guests who joined us for our Waterfall and Fall Color Tours. We hope you enjoyed your time with us, and look forward to seeing you again.
Hosts Cassie Rapert and State Naturalist Randy Hedgepath are already planning dates for the Spring Tours. These popular three day tours focus on the beauty and history of some of our most majestic falls and include educational seminars and interpretive programs unique to each location. Also included are meals, lodging and transportation to our various destinations. We will announce our Spring Tour Dates soon!


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Who is mabus that nostradamus predictions told us of, Who was nostradamus? nostradamus was a 15th century physician and divination practitioner, he wrote in cryptic verses in the french language. in his day his skills as. Essential nostradamus release, obama's war on isis and, Essential nostradamus release, obama's war on isis and hogue's scottish referendum prediction. Predictions of nostradamus 2014, Many of nostradamus' prophecies have come true such as from the great fire of london (1666), the french revolution (1789), the rise of napoleon and adolf hitler.
Nostradamus predictions about isis, the islamic state: the, Nostradamus predictions about isis, the islamic state: the sharia law puts obama on isis. robin williams, in memoriam. Predictions of nostradamus: from obama to the antichrist, "a telling documentary about the startling connections between the 15th century prophet nostradamus and 9/11, barack obama, bush, and the november elections," says. Nostradamus obama prophecies revealed - daily squib, Most of the nostradamus quatrains deal with disasters, such as plagues, earthquakes, wars, floods, invasions, murders, droughts, and battles.
Patrick bernauw - nostradamus, obama and 2012, Nostradamus, obama and 2012 posted on thursday, 16 july, 2009 | 32 comments columnist: patrick bernauw nostradamus strikes again. google "obama. Prophecies !!! for 2012 - 2014 following obama re-election, Hello ats, i bring to you today a few prophecies that were brought to my attention by a close friend, who came across an interesting chap that has quiet a story to. Nostradamus ' dragon 2012 /2014 predictions | prophecy, "because there is only one thin hair between divine information and pure imagination!" universal predictions from august 30 th 2012 to february 19 th 2014.


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Boasting a unique design, the French Connection Game On Large Leather Shoulder Bag features a real leather construction with twin grab handles and a main zip fastening. With a front fold over flap which conceals a front zip pocket, this bag has a large main compartment with an inner zip pocket for extra storage. K.D.
Dimensions: H:32 x W:34cm
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Please see our returns policy.
French Connection Lyla Bowler Bag - Hornbeam/Black
French Connection Game On Large Leather Envelope Clutch
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To achieve healthy skin, first and foremost is to thoroughly cleanse your skin from any make-up, debris and impurities. Even if you don't wear any make-up, cleansing is still very important to avoid oil and dirt build-up that causes whiteheads, blackheads (oxidized oil), dead skin cells and even pimples. Finding the right cleanser is not as easy as you may think. The cleanser that you use should be suitable for your skin type and condition while not causing your skin to feel tight or taut. After cleansing, your skin should feel fresh, smooth, soft and bright.
For the past month, I've been testing out a couple of cleansers and today I shall finally review them. Origins Checks and Balances, Skineeds Age Defense Silky Cleansing Cream, La Mer The Cleansing Foam, Missha Effectual O2 Bubble Cleanser, Dermalogica Special Cleansing Gel, Enjoy Your Rice Day Facial Soap.
Read on for the individual reviews.
Origins Checks and Balances (150ml/RM95)
This frothy face wash is designed to balance out the two skin condition of combination skin which is dry and oily. Only a pea-sized amount of the mousse-like cleanser is needed to create a lot of foam making the tube lasts for a very long time. Broad Leaf Extract discourages excess oil production while Wheat Protein balances and protects dry areas. No tautness or tightness is felt after cleansing instead skin feels smooth and very refreshed with a minty feeling. This cleanser also contains tourmaline (a gem stone) which actually makes water wetter to more easily disperse dirt and sebum. The aromatic scent is provided by Bergamot, Spearmint and Lavender. Cleansing has never felt so enjoyable with the spearmint smelling like Christmas.
Skineeds Age Defense Silky Cleansing Cream (100g/RM6)
This cleansing cream is enriched with 100% pure orange essential oil which is packed with Vitamin C and natural emollients to protect against aging and environmental aggression. The orange scent is very distinct but not in a negative way. Unlike other cleansing creams, a small amount of this cream lathers up quite a bit making the cleansing process more satisfying. Skin feels clean but slightly taut after cleansing, which is unexpected from a cleansing cream. The product has to be stored upside down to avoid the orange oil from accumulating at the tube's cap. this product is available from Price Abuse.
La Mer The Cleansing Foam (125ml/RM265)
This product is marketed in Asia as a whitening cleansing foam but it does not have any whitening ingredients and is actually exactly the same as the US' version of the Cleansing Foam. It contains marine extracts which have anti-irritation and calming properties, a combination of fine jade and white pearl powders that are rich in amino acids to gently polish the skin, magnetized tourmaline, and Deconstructed Waters to aid the loosening of debris without having to cleanse with much force. Only a small amount is needed to create a lot of lather to thoroughly cleanse skin without feeling tight or taut. There's a slight cooling feeling on the skin after cleansing and skin feels very smooth, looking immediately brightened.
Missha Effectual O2 Bubble Cleanser
I initially used the sample of this cleanser that I got to wash my brushes and I was surprised at how clean my brushes got; murky foundation all out in one wash. I decided to use it on my face and indeed this cleanser work as a foam cleanser and removes makeup as well. Enriched with O2 Carrier Liquid, it purifies and revitalizes the skin. This products give a lot of bubbles when lathered. An excellent cleanser for deep cleansing. Should be available at Missha Stores
Dermalogica Special Cleansing Gel
Um... it cleansed... and that was it. Nothing special. Not a lot of foam. Available at Dermalogica agents.
Enjoy Your Rice Day Facial Soap (100g)
I got this at the beauty expo for RM5 (regular price unknown) and just thought I'd give it a try. Apparently, it is a recommended product by a famous Taiwanese show (Nu Ren Wo Zui Da) and had good reviews so I was quite happy that my instinct told me to buy it. This bar soap contains Rice Bran Oil which is used traditionally in Japan to smoothen skin. It is believed that rice bran oil can help stimulate skin's collagen production making skin feel firmer as well and also improves blood circulation for a healthy and glowing complexion. I found out about the information on these benefits only after I've used the product and I've come to believe now that it is true. This pleasantly fragrant soap give lots of foam with just a few rubs in a wet palm. Surprisingly, the skin did not feel any tightness or tautness after cleansing and more obvious than any other cleansers, my skin looked immediately brightened.
This product is available from Vee-Man Beauty. Click for locations.
I have two more cleansers to try and review which is Clarins Gentle Foaming Cleanser and Cetaphil Gentle Skin Cleanser so do look out for their reviews in the near future.
Photo Credit: www.origins.com, www.priceabuse.com, www.nongmiu.com, www.missha.ae, www.worlddutyfree.com
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Grand Alliance members comment on possible Grand Alliance composition
Following the recent Grand Alliance press announcement on the 2005 product upgrade, the CEOs of Grand Alliance members Hapag-Lloyd, MISC, NYK and OOCL jointly expressed that they were united in their pledge to continue providing a high quality service to their customers.Should there be any amendments to the composition of the Grand Alliance in 2006, the new vessels ordered by Hapag-Lloyd, MISC, NYK and OOCL will be deployed to meet the expected growth in demand, and services will be further enhanced to offer more options for customers.
The four Grand Alliance members of Hapag-Lloyd, MISC, NYK and OOCL, with their combined resources and expertise, are confident that they can provide the top level of service.
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|Uloola Track
This pleasant walk takes you from Heathcote to Waterfall Station. This walk ventures into central Royal National Park along a well maintained bush track. The walk goes via a beautiful set of waterholes and rock flats at Karloo Pools. The walk continues to the peaceful campsite at Uloola Falls and then along a service trail, to Waterfall Railway Station. (open in app)
Bushwalking track notes photographs, maps and camping spots for Uloola Track (Heathcote to Waterfall)
Map of Walk
Map of Uloola Track (Heathcote to Waterfall)
Problem loading PDF Try here
Map Controls - Show Contours | Hide Path | Hide Distances | Hide Names
Map Scale 1 km
Base maps are used under licence and is © Department of lands Panorama Avenue Bathurst 2795 www.lands.nsw.gov.au
Maps that cover the walk area (please always carry maps of the area)Print a map and track notes here
Photo Gallery
Cross sectional view of the Uloola Track (Heathcote to Waterfall) bushwalking track
Analysis and summary of the altitude variation on the Uloola Track (Heathcote to Waterfall) bushwalking track
Overview of this walks Grading - Based on the AS 2156.1 - 2001
These details are new. This new feature still requires more testing and refining. Please use the 'Walker Feedback' for report specific issues. Please e-mail Matt if you have any general comments. Hope you find it helpful.
Under this standard, a walk is graded based on the most difficult section of the walk.
Some more detail of this walks Grading
Here is a bit more details explaining the grading looking at sections of the walk.
Around 8km of this walk has short steep hills, whilst the remaining 3km has gentle hills with occasional steps.
Quality of track
10km of this walk follows a formed track, with some branches and other obstacles and another 950m follows a clear and well formed track or trail. Whilst another 590m follows a rough track, where fallen trees and other obstacles are likely and the remaining 200m follows a smooth and hardened path.
6km of this walk has minimal directional signs and another 4.5km has directional signs at most intersection. The remaining (1.1km) is clearly signposted.
Experience Required
Around 6km of this walk requires no previous bushwalking experience, whilst the remaining 4.8km requires some bushwalking experience.
This whole walk, 11km is not usually affected by severe weather events (that would unexpectedly impact safety and navigation).
This whole walk, 11km has limited facilities (such as not all cliffs fenced).
Track Notes
Getting therePlan your trip to the start of the walk and back from the end of the walk
Public Transport links currently not working, sorry
Near by
Campsites in the park
Bonnie Vale camping groundNorth Era camping groundUloola Falls camping ground
Nearest know Outdoor Stores near the start of this walk
A list of the nearest UHF CB repeaters I found to Uloola Track (Heathcote to Waterfall).
Weather and Park info
Fire Danger
This walk passes Greater Sydney Region fire area which currently has a HIGH rating and No fire ban in place. (Downloaded 35 minutes ago)
Please Note: Each park may have its own fire ban, this rating is only valid for today and is based on information from the RFS Please check the RFS Website for more information.
Weather and Climate
Weather and Climate summary detailed weather and climate information here
Royal National Park Link to official closures and fire bans page
Region: Sydney & Surrounds
Park fees Camping Facilities
Current Park Closure information for Royal National Park
Closure information last downloaded Wednesday 26th of November 2014 03:00 PM
Lady Wakehurst Drive closed for essential maintenance (Ends Wednesday 26 November)
Roads and Maritime Services (RMS) will be doing maintenance on the following roads in Royal National Park which will result in the some road closures:
Locations affected: Werrong Beach track, The Coast track, Red Cedar Flat picnic area, Upper Causeway picnic area
Trail closure
Florence Parade trail is closed to the public between Grays Point and the Royal National Park Office until further notice due to a pollution incident.
Penalties apply for non-compliance
For more information, please contact the Royal National Park Office on (02) 9542 0632 or visit the NSW national parks safety page.
Closed areas: Garie Road closure for RMS essential maintenance (Thursday 27 November to Friday 28 November)
Roads and Maritime Services (RMS) will be doing maintenance on the following roads in Royal National Park which will result in the some road closures:
Locations affected: Garie Beach picnic area, Governor Game lookout
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One question before I start.
Would you eat one of the above creations?
If you answered yes, please continue.
If you answered no, then you answered no.
Carry on.
Take out the garbage or go for a walk.
There's nothing more to see or read here.
Here is a picture of a funny monkey to help you forget why you came here in the first place.
I have lived with 4 women/daughters for the better part of 29 or so years.
I'm used to all the stuff associated with their personal hygiene too;
hair products, hair brushes, blow dryers (they torch at least one on a monthly basis),
gel/goop crap for their hair, conditioners, face wash [with Hawaiian pumice!], ass wash, back wash, foot wash and feminine mouthwash.
It never ceases to amaze me the amount and selection of products available.
Guys have two major categories: shaving and deodorant.
We don't need much more.
There are some products available to guys as well that simply elude me.
Axe body spray, for one.
Oh, it's infused with pheromones so no woman can resist you.
Let's lay that one to rest and say that if you stink like BO or smell like Charles Manson, no pheromone spray, body wash or Godly bar of soap will ever eliminate that.
No wonder you go home alone.
Living with women I've gotten used to oddly named products that have no relation to anything 'male';
'The Brusher', Pink Grapefruit Exfoliate, Slick Works, Catch the Wave gel, Got2B hair motherfu*&$^ Complex,
TRESemme Simply No Frizz with *Frizz Defense!( and God knows how many more).
I used to think these products were okay as long as they didn't interfere with my life as a hair growing Neanderthal.
That thinking changed a few weeks ago when I went to the fridge after several perfectly chilled Harpoon Leviathan Ales.
Looking into the freezer I spotted an Italian Ice that was the perfect size for a nightcap dessert.
I picked it out and saw the name 'Whoosh' on the lid.
Judging from the color is was a blue raspberry ice.
One of my favorite 'ice' flavors.
As I began lifting the lid off I noticed that this was not 'ice' at all but something called 'Shower Jelly'.
My monkey brain screamed: DO NOT EAT THIS!
The company that made it is was called 'Lush'.
They make fresh handmade cosmetics.
Or do they?
Their shower jellies include 'Sweetie Pie' and 'Whoosh' (the one I almost ate).
They have bath bombs with names like Butterball, Bon Bomb, Dragon's Egg, Sex Bomb and The Sicilian
(oooh, tease me with your seductive Italian flare! Grazie!)
This company has stuff called 'Gorilla Perfume'.
Gorilla? For a woman?
Maybe a hairy woman.
Why not call it 'Primate Scent Enhancer'?
What's the difference?
The names are quite amusing though . . .
'The smell of weather turning' . . . (here comes the big one, honey!)
'Snowshowers' . . . (get out the shovel you lazy, fat bastard!)
'1,000 Kisses Deep' . . . (not going there, evah)
The other thing I almost ate was a 'Lush' bath bar.
These things look like little oval white hunks of chocolate imbedded with yummy things . . . like nuts and stuff.
I almost ate a 'Wiccy Magic Muscles' bar that looked more like a white chocolate Snickers bar than a massage bar.
My olfactory senses slowly connected with my brain and said, "Dude? The tummy ain't gonna like this. It ain't food."
Nuff said.
I had learned my lesson.
Lush has some great names for their products though;
Nutts ( a massage bar. Not touching the name)
Strawberry Feels Forever (giving them a *Beatle for that one)
Heavenilli (looks like Sushimi, minus the wasabi)(rub sushi all over my face, please)
After 8:30 (looks like a piece of carrot cake with 1" of cream cheese frosting, who can resist?)
Dorothy (a bath bar that looks like a little doggie turd on a blue urinal hockey puck)(truth)
Guys like me can't understand this stuff.
We are happy that it makes you happy but we will never comprehend the obvious product innuendo.
And there is much of it with 'Lush'.
Consider their Body Butters:
King of Skin
Schnuggle (so cute the name alone makes me gag)
Aqua Mirabilis (?)(is that a constellation?)
You Snap the Whip (Shades of Quentin Tarantino)
And last but not least, 'Buffy';
Massage our Buffy body butter all over your wet skin in the bath or shower to make you softer and smooth to the touch, paying special attention to your backside. We add ground rice, almonds and beans to Buffy to act as exfoliants; the rough textures eliminate lumps and bumps and sloughs away dry skin cells to reveal brighter, fresher looking skin. Rinse off the exfoliating bits and pat yourself dry. There's no need for body lotion after a Buffy slaying session, because the cocoa and shea butters keep your skin beautifully smooth, moisturized and soft to the touch.
Smack my ass and call me Sally, this is true.
I would write more about this company but I have a mad date with an extravagant bath bar called, 'Blue Skies and Fluffy White Clouds'.
And I think she's taking me for one hell of a soapy ride . . .
Kirkland Oliver was a regular on Friday afternoons at the cigar store where I work in Boston.
He was an affable and enigmatic man still living life like it was 1969.
We hadn't seen Kirk in over three weeks, a rare thing for a guy that you could count on like clockwork
to show up and get some rolling tobacco and papers (6oz of 3 Citadels and 17 Modiano Club Papers).
On a dark whim, I Googled 'Kirkland Oliver – obit- Boston' and came up with a result that broke my heart.
Kirkland died July 29th at 66 years of age of prostate cancer.
What follows is a personal obituary and tribute to a gentle soul many people have never had the good fortune to meet.
This was written in part by myself but a more substantial portion was written by my dear friend and associate, Will Marks.
Enjoy our candid view of a man that truly knew who and what he was.
Kirkland used to make collages out of stuff most folks would discard.
He would make stuff featuring his pals' names featuring all kinds of symbols and references.
The message was pretty much the same: Kirkland was telling us that we were cool by his calculus.
These works of art weren't made for everyone.
Just the people that Kirkland let into his cosmic circle.
Speaking of calculus, one time a fellow was in the store going on and on about his math ability.
Kirkland asked him what he did and the fellow said, "I'm a quant!" then he shared some detail in a condescending tone to make sure Kirkland got it saying, "I'm into heavy math for the investment industry."
The store got quiet and Kirkland looked at him and said, "Yeah, I was into math too, used to make my dick hard in 3rd grade so I got into making shapes and artwork all based on math."
Sizing up the quant he added "…but I outgrew that stuff, if you dig."
KO had an unmistakeable 'jazz' quality about him.
From the way he walked (with a huge wooden walking stick) to the way he talked he had a rhythm and undeniable groove.
It was his 'groove' and his alone as he walked to the beat of his own personal drummer.
There was nothing quite like Kirkland striding into the store with the overpowering scent
of a double dose of patchouli oil announcing his arrival.
He'd flash that winning crooked smile and say "Peace" and get into the discussion always leading it back to the tenants of his homespun philosophy (equal parts Hendrix/Shakespeare/McLuhan/Grateful Dead/Health Food Store Chatter/Cantab lounge misinformation) with detours along the way typically including the night Sun Ra played Slug's when he was blitzed on Owsley acid or how Mingus tore it up another night, his recent favorite band Girls On Top,
or how the Boston Public Library's address was proof of dark plots.
"You know what the number of the Boston Public Library is, man? 666! It's the sign of the 'Cipher', you dig?"
Kirk would chuckle and say, "Peace . . . peace."
Naturally, Kirkland bragged about his family and how he played the violin.
Then there were his cosmic rants about people who were too uncool to be friendly.
When Kirk would get rolling papers (always 13 until the size changed and it went to 17)
he always challenged me to grab the correct number of papers.
Sometimes I would and he would smile and say, "Nice, man. Peace."
And he always rolled one menthol cigarette on Fridays.
Kirkland's Friday pronouncements—"All the world's a stage", "What goes around comes around", "Ain't nothing new under the sun", "Can you dig it?", "It's the Illuminati man they are controlling everything these days", "Man I was checking out the internet you know where that is man?", "Did you know I was in a coma man? Yeah, didn't even know my wife when I woke up!", "I love the smell of that cigar it's getting me high.", "I'll take some menthol and 17 packs of rolling papers."—are now a thing of the past; part of the store's hallowed lore.
Kirkland has joined the pantheon of greats who went before him.
No sweat, Kirkland the larger than life friend to all who were willing, who put the "hep" in hepcat,
will live on in the hearts of all who were lucky enough to have been touched by his friendship and love.
I know many things about this man but some I can't share here.
These were his gifts.
I know he always made me smile in his own and original hepcat way.
And although the sun was shining in Boston today, the city for me was just a darker shade of grey without Kirk . . .
Sleep well, my friend.
Oh, and Peace . . .
Hail to Kirkland for he knew who and what he was:
~m & Will Marks
This video moved me in so many ways and I am proud to share it here on my blog.
It was suggested by SKennedy of the Alzheimer's Foundation.
I hope and pray that people watch the video, send this link to family and friends, share it with the world.
What is the one thing you never want to forget?
Your name?
The day of the week?
Favorite songs?
The names of family and friends that you love?
Ordinary everyday objects?
Caring for loved ones afflicted with this insidious disease, I have personally witnessed all of the above at one point in time.
Your heart breaks for them but you know you have to move on because the progression of Alzheimer's
never sleeps.
Sometimes, as a caregiver, nor do you.
I personally never want to forget how much I love my Pamela, my three incredible daughters and my twin sister Maureen.
(there are so many more on my list but I needed to shave it or you would be here forever)
If ever I should forget, I pray that they all softly remind me from time to time.
This disease takes and takes and takes until there is literally nothing left but skin and bones.
Just imagine a world without Alzheimer's.
That, my friends, is a beautiful thing.
Once again, please consider supporting me in my Walk to Remember on September 30th. [see my link below]
I will be walking for my Mom, Dad and Pamela's Dad who is currently in the middle stages of this leviathan monster.
I can't seem to get away from it so I walk.
And I will continue to walk.
For all the lost souls . . .
One thing.
Just one thing.
It's something we can easily remember.
But how about them?
A world without Alzheimer's is a beautiful thing.
the link for my personal fundraising page
True strength
is being able to hold it all together
when everybody else is expecting you to fall apart.
Life can be so damn confusing . . . like now.
And yeah, oddly enough I'm fine.
Most cryptic.
I read a post on Facebook from a 'friend' tonight.
I have no idea if he wrote it or found it on the interwebz.
That said, it moved me to tears reminding me of my Mom and Dad's struggle with Alzheimer's.
It's called 'When Tomorrow Starts Without Me' and is a simply beautiful epitaph and message of hope that should be shared.
I'm missing my Mom and Dad tonight the way they used to be . . . more than usual.
I'm over remembering the bad stuff.
Moving on.
Please share this . . .
Thank you, JohnD for posting!
attributed to David M Romano
When tomorrow starts without me
And I'm not there to see;
If the sun should rise and find your eyes
All filled with tears for me.
I wish so much you wouldn't cry
The way you did today;
While thinking of the many things
We didn't get to say.
I know how much you love me
As much as I love you;
And each time that you think of me,
I know you'll miss me too.
But when tomorrow starts without me
Please try to understand,
That an angel came and called my name
And took me by the hand.
She said my place was ready
In heaven far above;
And that I'd have to leave behind,
All those I dearly love.
But as I turned to walk away,
A tear fell from my eye;
For all my life, I'd always thought
I didn't want to die.
I had so much to live for,
So much yet to do;
It seemed almost impossible,
That I was leaving you.
I thought of all the yesterdays,
The good ones and the bad;
I thought of all the love we shared,
And all the fun we had.
If I could relive yesterday
Just even for awhile,
I'd say goodbye and kiss you
And maybe see you smile.
But then I fully realized
That this could never be;
For emptiness and memories
Would take the place of me.
And when I thought of worldly things
I might miss come tomorrow;
I thought of you, and when I did,
My heart was filled with sorrow.
But when I walked through heaven's gates
I felt so much at home;
When God looked down and smiled at me
From His great golden throne.
He said, "This is eternity
And all I've promised you;
Today your life on earth is past,
But here it all starts anew."
"I promise no tomorrow,
But today will always last;
And since each day's the same day,
There's no longing for the past."
"But you have been so faithful,
So trusting and so true;
Though at times you did do things,
You knew you shouldn't do."
"But you have been forgiven
And now at last you're free;
So won't you take my hand
And share my life with me?"
So when tomorrow starts without me,
Don't think we're far apart
For every time you think of me,
I'm right here in your heart.


text:
On Purpose
On Purpose
We develop the best professionals into the next generation of social enterprise leaders - those who will tackle social and environmental problems by harnessing the power of business for good.
London, United Kingdom
29 Aug 2013
Opportunity has expired
Compensation details:
During the 1 year leadership programme you will be paid £21k p.a. We encourage people to think about this as a stipend for a paid year of training and development.
On Purpose Associate
Use the skills you've built to kick-start your social-purpose career (year-long leadership programme)
London, United Kingdom
Applicants are required to hold the relevant Visas/Work Permits
Compensation details:
During the 1 year leadership programme you will be paid £21k p.a. We encourage people to think about this as a stipend for a paid year of training and development.
To view this opportunity please sign back in or join
(it takes 10 seconds and might change your life!)
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On Purpose equips high-flying professionals with the experience, skills and networks to launch a career combining the power of business with social and environmental objectives.
On Purpose is a one-year, paid leadership programme that combines two different work placements with intensive 1:1 support and world-class training provided by professionals from high-profile organisations across different sectors such as McKinsey, Bain, the Big Issue, UnLtd and Bridges Ventures.
There is enormous potential for using business principles to do more social good. We are looking for outstanding professionals with a track record of achievement and two or more years work experience in order to launch you in your career with social purpose.
On Purpose's leadership programme can change your career and will connect you to like-minded people working to solve some of society's biggest issues. You will fast track your social purpose career by learning from and tapping into hands-on placements, 1:1 support, your peers on the programme and On Purpose's sector-spanning networks. Following the programme, Fellows continue to benefit from our extensive network of other experienced professionals.
Questions? Ask us on Facebook: www.facebook.com/onpurposeuk or why not come and meet current Associates, Fellows and the On Purpose team in a Central London location at one of our events.
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text:
Heat Wave view
Eye Candy: California Love view
Eye Candy: Southern Sensation view
Photo Credit: Eric Ganison Photography
"I'm focused on my dreams and giving my son the world," says Guidroz. "Everything else...
"I'm focused on my dreams and giving my son the world," says Guidroz. "Everything else is secondary right now."
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SURevolution is excited to announce its cooperation and collaboration with renowned furniture designer Tucker Robbins in the Architectural Digest Home Design Show. The Show will take place on March 26 for trade and VIP guests and open to the public from the Friday 27th to Sunday 29th. We invite you all to attend this exceptional event and to support this alliance founded on our common passion for culturally, ecologically and socially responsible design.
Join our network of non-profits, companies and individuals who believe social change can happen through design.Become A Member
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text:
Lady Colts beat Lady 'Cats to go to 21-0
Thursday evening volleyball action saw the team with the area's best record at the 'Cats Lair... More
- Rod Johnson The Daily Jeffersonian
Thursday evening volleyball action saw the team with the area's best record at the 'Cats Lair... More
WOODSFIELD -- Make it four Pioneer Valley Conference volleyball crowns in as many years for the... More
BARNESVILLE -- Following a loss in the OVAC semifinals Tuesday and finishing third, the... More
Closing out the regular season with Senior Night Wednesday, the visiting Zanesville Bishop... More
COLUMBUS -- R. G. Florey scored an unassisted goal at the 87:43 mark to snap a scoreless deadlock... More
League title hopes and a boatload of computer playoff points will be on the line for Meadowbrook,... More
NEW CONCORD - It will be another road trip for the Muskingum University Fighting Muskies as the... More
BYESVILLE -- Talk about a wake-up call! Visiting Martins Ferry came to town with upset on its... More
SARAHSVILLE -- Host Shenandoah High and Buckeye Trail earned spots in Saturday's O.V.A.C Class... More
NEW CONCORD - John Glenn High has a long tradition of excellence on the golf course. No Muskies'... More
STEUBENVILLE - Caldwell High entered as the No. 4 seed in the Ohio Valley Athletic Conference... More
NEW CONCORD -- John Glenn High continued to roll along on Tuesday night picking up a convincing... More
NEW CONCORD -- John Glenn High rolled past visiting New Lexington for a Muskingum Valley League... More
BYESVILLE - While John Glenn will be competing as a team, Meadowbrook High senior Damon Moore... More
Area soccer teams learned their destinations and match-ups for the upcoming Ohio High Athletic... More
MAGNOLIA -- The Newcomerstown High Lady Trojans dropped an Inter-Valley Conference setback to... More
The Cambridge Lady Bobcats suffered a 3-0 setback to visiting Philo High in non-league girls... More
John Glenn Cheer Clinic The John Glenn High School Cheer Clinic will take place Wednesday, Oct. 8... More
WEST LAFAYETTE -- The Muskingum University women's golf team finished fourth (437) at River... More
Dallas Guy (Meadowbrook), a sophomore at the University of Rio Grande, finished in first place... More
Meadowbrook, Buckeye Trail and Shenandoah were awarded No. 1 seeds as the OHSAA Sectional... More
Visiting John Glenn came calling on Cambridge High on Saturday afternoon in a 'Kick For A Cure'... More
McCONNELSVILLE -- The John Glenn High Muskies took their game on the road Friday night to face... More
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BYESVILLE -- While a couple of big school teams from downstate in West Virginia and the premier... More


text:
Harbor Island House Rental Photos and Description
3 bedrooms, 2 full baths, sleeps 8
Because of the limitations of the "Instant Quote" system, quotes for stays of less than 1 week are approximate. We are happy to give you a precise quote and break out all costs for you--Just email us! We manage 18 Harbor Island vacation properties. Please email for availability; calendar feature is not used.
Pet Friendly, Excellent Ocean View & Direct Beach Access! This beautiful second row, 3 bedroom, 2 full bath beach home is newly remodeled and professionally decorated. It features large front and back decks--both with dining tables and chairs, beautiful ceramic tiles throughout, and a wood burning fireplace in the livingroom. Very short walk to Beach & Racquet club and just steps to the beach on your private path & boardwalk. Gorgeous direct ocean view from the spacious deck stretching full length across the back of this home. There is covered parking below the house for 2 cars, & open parking adjacent to the home for 2 more vehicles. Quality furnishings throughout. Ceiling fans and flatscreen cable TV and DVD players in all three bedrooms and living area. High speed wireless Internet access. Stereo radio/CD player with IPOD dock. King bed in master, second bedroom has one double bed, third has two twins, and a queen inflatable to expand sleeping options. The outdoor shower is perfect for rinsing off after the beach. This home is pet friendly, limited to one small to medium dog. Sorry, no cats please. All rates exclude taxes and vehicle gate pass; departure cleaning added to stays of less than one week. Pet fee is $15 per night to a maximum of $90 per stay; dogs only, 1 pet maximum. No smoking, please.
- Suitability:
- Long-term Renters Welcome
- children welcome
- non smoking only
- pets considered
- wheelchair inaccessible


text:
ovuleLine breaks: ovule
Pronunciation: /ˈɒvjuːl , ˈəʊ-/
Definition of ovule in English:
The part of the ovary of seed plants that contains the female germ cell and after fertilization becomes the seed.
Example sentences
- The number of pollen tubes and ovules in the ovaries of each of six dissected pistils from each cross is shown.
- It is well known that most flowering plants produce more ovules than the number of seeds they mature.
- Once the pollen has fertilized the egg cell contained within the ovule, the ovule develops into a seed, and the ovary of the enclosing carpel begins to enlarge and ripen, forming the fruit.
early 19th century: from French, from medieval Latin ovulum, diminutive of ovum.
- 1
ovular adjective
- Example sentences
- These filial organs are enclosed by a maternal seed coat, derived from one or both ovular integuments.
- Nevertheless, there is a consensus that the palisade layer, which develops from the outer epidermis of the outer ovular integument, is critical in determining the permeability property of a seed coat.
- However, any role of ethylene, produced due to damaging the ovular base, cannot be excluded.
Definition of ovule in:
- US English dictionary
What do you find interesting about this word or phrase?
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Word of the day prepotent
Pronunciation: ˌprēˈpōtnt
greater than others in power or influence


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Channel Account Executive
Location - New York, Boston, Chicago, NY
All Relocation Fees will be covered by the company.
Education and Training Requirements
Bachelor's degree (GA/BS) from a four-year college or university or equivalent combination of education and experience.
Work Experience ...
Nov 23 -
Mortgage Loan Officer
Mortgage Loan Officer
Reviews and analyzes mortgage and consumer loan applications for approval or denial. Interviews and assists members with loan inquiries and applications, and provides financial counseling. Responsible for an effective ...
Nov 21 -
Accounting Manager
Position Description
Mortara Instrument, a fast-growing global leader in non-invasive cardiology devices, is seeking an exceptional candidate to fill the position of Accounting Manager.
We are looking for a candidate that has strong analytical abilities and enjoys ...
Nov 20 -
Internal Audit Manager
As part of the Corporate Services staff, the Internal Audit Manager is responsible for evaluating, planning, developing, maintaining, facilitating, and executing the overall global audit effort, ensuring that audit coverage is appropriate for the control and risk ...
Oct 24 -
Accountant Controller
NRV, Inc.
N8155 American Street
Ixonia, Wisconsin 53036
Controller – Full Time Position
Oct 20 -
Branch Manager
***This is an over-staff position and will require travel at least twice a month within the southern part of Wisconsin***
The branch manager is responsible for the overall operations of the branch. The Company sets reasonable standards for delinquency, bad debt, slow file, ...
Oct 14 -
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text: Retrovirology - Latest Articles http://www.retrovirology.com The latest research articles published by Retrovirology 2014-11-19T12:00:00Z Human semen contains exosomes with potent anti-HIV-1 activity Background: Exosomes are membranous nanovesicles secreted into the extracellular milieu by diverse cell types. Exosomes facilitate intercellular communication, modulate cellular pheno/genotype, and regulate microbial pathogenesis. Although human semen contains exosomes, their role in regulating infection of viruses that are sexually transmitted remains unknown. In this study, we used semen exosomes purified from healthy human donors to evaluate the role of exosomes on the infectivity of different strains of HIV-1 in a variety of cell lines. Results: We show that human semen contains a heterologous population of exosomes, enriched in mRNA encoding tetraspanin exosomal markers and various antiviral factors. Semen exosomes are internalized by recipient cells irrespective of cell type and upon internalization, inhibit replication of a broad array of HIV-1 strains. Remarkably, the anti-HIV-1 activity of semen exosomes is specific to retroviruses because semen exosomes blocked replication of the murine AIDS (mAIDS) virus complex (LP-BM5). However, exosomes from blood had no effect on HIV-1 or LP-BM5 replication. Additionally, semen and blood exosomes had no effect on replication of herpes simplex virus; types 1 and 2 (HSV1 and HSV2). Mechanistic studies indicate that semen exosomes exert a post-entry block on HIV-1 replication by orchestrating deleterious effects on particle-associated reverse transcriptase activity and infectivity. Conclusions: These illuminating findings i) improved our knowledge of the cargo of semen exosomes, ii) revealed that semen exosomes possess anti-retroviral activity, and iii) suggest that semen exosome-mediated inhibition of HIV-1 replication may provide novel opportunities for the development of new therapeutics for HIV-1. http://www.retrovirology.com/content/11/1/102 Marisa Madison Richard Roller Chioma Okeoma Retrovirology 2014, null:102 2014-11-19T12:00:00Z doi:10.1186/s12977-014-0102-z /content/figures/s12977-014-0102-z-toc.gif Retrovirology 1742-4690 ${item.volume} 102 2014-11-19T12:00:00Z PDF Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation Background: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of different context in diverse HIV-1 strains on the fitness costs due to the T242N mutation has not been well characterized. To better understand the extent of fitness costs of the T242N mutation and the repair of fitness loss through compensatory amino acids, we investigated its fitness impact in different transmitted/founder (T/F) viruses. Results: The T242N mutation resulted in various levels of fitness loss in four different T/F viruses. However, the fitness costs were significantly compromised by preexisting compensatory amino acids in (Isoleucine at position 247) or outside (glutamine at position 219) the CTL epitope. Moreover, the transmitted T242N escape mutant in subject CH131 was as fit as the revertant N242T mutant and the elimination of the compensatory amino acid I247 in the T/F viral genome resulted in significant fitness cost, suggesting the fitness loss caused by the T242N mutation had been fully repaired in the donor at transmission. Analysis of the global circulating HIV-1 sequences in the Los Alamos HIV Sequence Database showed a high prevalence of compensatory amino acids for the T242N mutation and other T cell escape mutations. Conclusions: Our results show that the preexisting compensatory amino acids in the majority of circulating HIV-1 strains could significantly compromise the fitness loss due to CTL escape mutations and thus increase challenges for T cell based vaccines. http://www.retrovirology.com/content/11/1/101 Donglai Liu Tao Zuo Bhavna Hora Hongshuo Song Wei Kong Xianghui Yu Nilu Goonetilleke Tanmoy Bhattacharya Alan Perelson Barton Haynes Andrew McMichael Feng Gao Retrovirology 2014, null:101 2014-11-19T12:00:00Z doi:10.1186/s12977-014-0101-0 /content/figures/s12977-014-0101-0-toc.gif Retrovirology 1742-4690 ${item.volume} 101 2014-11-19T12:00:00Z PDF Structural basis of genomic RNA (gRNA) dimerization and packaging determinants of mouse mammary tumor virus (MMTV) Background: One of the hallmarks of retroviral life cycle is the efficient and specific packaging of two copies of retroviral gRNA in the form of a non-covalent RNA dimer by the assembling virions. It is becoming increasingly clear that the process of dimerization is closely linked with gRNA packaging, and in some retroviruses, the latter depends on the former. Earlier mutational analysis of the 5? end of the MMTV genome indicated that MMTV gRNA packaging determinants comprise sequences both within the 5? untranslated region (5? UTR) and the beginning of gag. Results: The RNA secondary structure of MMTV gRNA packaging sequences was elucidated employing selective 2?hydroxyl acylation analyzed by primer extension (SHAPE). SHAPE analyses revealed the presence of a U5/Gag long-range interaction (U5/Gag LRI), not predicted by minimum free-energy structure predictions that potentially stabilizes the global structure of this region. Structure conservation along with base-pair covariations between different strains of MMTV further supported the SHAPE-validated model. The 5? region of the MMTV gRNA contains multiple palindromic (pal) sequences that could initiate intermolecular interaction during RNA dimerization. In vitro RNA dimerization, SHAPE analysis, and structure prediction approaches on a series of pal mutants revealed that MMTV RNA utilizes a palindromic point of contact to initiate intermolecular interactions between two gRNAs, leading to dimerization. This contact point resides within pal II (5? CGGCCG 3?) at the 5? UTR and contains a canonical ?GC? dyad and therefore likely constitutes the MMTV RNA dimerization initiation site (DIS). Further analyses of these pal mutants employing in vivo genetic approaches indicate that pal II, as well as pal sequences located in the primer binding site (PBS) are both required for efficient MMTV gRNA packaging. Conclusions: Employing structural prediction, biochemical, and genetic approaches, we show that pal II functions as a primary point of contact between two MMTV RNAs, leading to gRNA dimerization and its subsequent encapsidation into the assembling virus particles. The results presented here enhance our understanding of the MMTV gRNA dimerization and packaging processes and the role of structural motifs with respect to RNA-RNA and possibly RNA-protein interactions that might be taking place during MMTV life cycle. http://www.retrovirology.com/content/11/1/96 Suriya Aktar Valérie Vivet-Boudou Lizna Ali Ayesha Jabeen Rawan Kalloush Delphine Richer Farah Mustafa Roland Marquet Tahir Rizvi Retrovirology 2014, null:96 2014-11-14T12:00:00Z doi:10.1186/s12977-014-0096-6 /content/figures/s12977-014-0096-6-toc.gif Retrovirology 1742-4690 ${item.volume} 96 2014-11-14T12:00:00Z PDF Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4 + T-cell subsets, including stem cell memory T-cells Background: CD4+ memory T-cells are a major target for infection by HIV-1, whereby latent provirus can establish and endure suppressive antiretroviral therapies. Although HIV-1 subtype C strains (C-HIV) account for the majority of HIV-1 infections worldwide, the susceptibility of CD4+ memory T-cells to infection by CCR5- (R5) and CXCR4-using (X4) C-HIV is unknown. Here, we quantified the susceptibility of naïve and memory CD4+ T-cell subsets, including stem cell memory T-cells (TSCM), to infection by HIV-1 subtype C (C-HIV) strains from treatment-naïve subjects who progressed from chronic to advanced stages of disease whilst either maintaining CCR5-using (R5) viruses (subjects 1503 and 1854), or who experienced emergence of dominant CXCR4-using (X4) strains (subject 1109).FindingsWe show that R5 and X4 C-HIV viruses preferentially target memory and naïve CD4+ T-cell subsets, respectively. While TSCM were susceptible to infection by both R5 and X4 C-HIV viruses, the proportion of infected CD4+ T-cells that were TSCM was higher for R5 strains. Mutagenesis studies of subject 1109 viruses established the V3 region of env as the determinant underlying the preferential targeting of naïve CD4+ T-cells by emergent X4 C-HIV variants in this subject. In contrast, the tropism of R5 C-HIV viruses for CD4+ T-cell subsets was maintained from chronic to advanced stages of disease in subjects 1503 and 1854. Conclusions: This study provides new insights into the natural history of tropism alterations for CD4+ T-cell subsets by C-HIV strains during progression from chronic to advanced stages of infection. Although not preferentially targeted, our data suggest that TSCM and other memory CD4+ T-cells are likely to be viral reservoirs in subjects with X4 C-HIV infection. http://www.retrovirology.com/content/11/1/97 Kieran Cashin Geza Paukovics Martin Jakobsen Lars Østergaard Melissa Churchill Paul Gorry Jacqueline Flynn Retrovirology 2014, null:97 2014-11-12T12:00:00Z doi:10.1186/s12977-014-0097-5 /content/figures/s12977-014-0097-5-toc.gif Retrovirology 1742-4690 ${item.volume} 97 2014-11-12T12:00:00Z XML ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity Background: The role of innate immunity in general and of type I interferon (IFN-I) in particular in HTLV-1 pathogenesis is still a matter of debate. ADAR1-p150 is an Interferon Stimulated Gene (ISG) induced by IFN-I that can edit viral RNAs. We therefore investigated whether it could play the role of an anti-HTLV factor. Results: We demonstrate here that ADAR1 is also expressed in the absence of IFN stimulation in activated primary T-lymphocytes that are the natural target of this virus and in HTLV-1 or HTLV-2 chronically infected T-cells. ADAR1 expression is also increased in primary lymphocytes obtained from HTLV-1 infected individuals. We show that ADAR1 enhances HTLV-1 and HTLV-2 infection in T-lymphocytes and that this proviral effect is independent from its editing activity. ADAR1 expression suppresses IFN-? inhibitory effect on HTLV-1 and HTLV-2 and acts through the repression of PKR phosphorylation.DiscussionThis study demonstrates that two interferon stimulated genes, i.e. PKR and ADAR1 have opposite effects on HTLV replication in vivo. The balanced expression of those proteins could determine the fate of the viral cycle in the course of infection. http://www.retrovirology.com/content/11/1/93 Anne Cachat Sandrine Alais Sébastien Chevalier Chloé Journo Floriane Fusil Hélène Dutartre Adrien Boniface Nga Ko Antoine Gessain François-Loïc Cosset Rodolphe Suspène Jean-Pierre Vartanian Renaud Mahieux Retrovirology 2014, null:93 2014-11-12T12:00:00Z doi:10.1186/s12977-014-0093-9 /content/figures/s12977-014-0093-9-toc.gif Retrovirology 1742-4690 ${item.volume} 93 2014-11-12T12:00:00Z PDF Stabilization of the ß-hairpin in Mason-Pfizer monkey virus capsid protein¿ a critical step for infectivity Background: Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a mature core – a hexameric lattice protein shell that protects retroviral genomic RNA. Subtle conformational changes within CA induce the transition from the immature lattice to the mature lattice. Upon release from the precursor, the initially unstructured N-terminus of CA is refolded to form a β-hairpin stabilized by a salt bridge between the N-terminal proline and conserved aspartate. Although the crucial role of the β-hairpin in the mature core assembly has been confirmed, its precise structural function remains poorly understood. Results: Based on a previous NMR analysis of the N-terminal part of M-PMV CA, which suggested the role of additional interactions besides the proline-aspartate salt bridge in stabilization of the β-hairpin, we introduced a series of mutations into the CA sequence. The effect of the mutations on virus assembly and infectivity was analyzed. In addition, the structural consequences of selected mutations were determined by NMR spectroscopy. We identified a network of interactions critical for proper formation of the M-PMV core. This network involves residue R14, located in the N-terminal β-hairpin; residue W52 in the loop connecting helices 2 and 3; and residues Q113, Q115, and Y116 in helix 5. Conclusion: Combining functional and structural analyses, we identified a network of supportive interactions that stabilize the β-hairpin in mature M-PMV CA. http://www.retrovirology.com/content/11/1/94 Martin Obr Romana Hadravová Michal Dole¿al Ivana K¿í¿ová Veronika Papou¿ková Luká¿ ¿ídek Richard Hrabal Tomá¿ Ruml Michaela Rumlová Retrovirology 2014, null:94 2014-10-30T12:00:00Z doi:10.1186/s12977-014-0094-8 /content/figures/s12977-014-0094-8-toc.gif Retrovirology 1742-4690 ${item.volume} 94 2014-10-30T12:00:00Z XML Host and viral determinants for MxB restriction of HIV-1 infection Background: Interferon-induced cellular proteins play important roles in the host response against viral infection. The Mx family of dynamin-like GTPases, which include MxA and MxB, target a wide variety of viruses. Despite considerable evidence demonstrating the breadth of antiviral activity of MxA, human MxB was only recently discovered to specifically inhibit lentiviruses. Here we assess both host and viral determinants that underlie MxB restriction of HIV-1 infection. Results: Heterologous expression of MxB in human osteosarcoma cells potently inhibited HIV-1 infection (~12-fold), yet had little to no effect on divergent retroviruses. The anti-HIV effect manifested as a partial block in the formation of 2-long terminal repeat circle DNA and hence nuclear import, and we accordingly found evidence for an additional post-nuclear entry block. A large number of previously characterized capsid mutations, as well as mutations that abrogated integrase activity, counteracted MxB restriction. MxB expression suppressed integration into gene-enriched regions of chromosomes, similar to affects observed previously when cells were depleted for nuclear transport factors such as transportin 3. MxB activity did not require predicted GTPase active site residues or a series of unstructured loops within the stalk domain that confer functional oligomerization to related dynamin family proteins. In contrast, we observed an N-terminal stretch of residues in MxB to harbor key determinants. Protein localization conferred by a nuclear localization signal (NLS) within the N-terminal 25 residues, which was critical, was fully rescuable by a heterologous NLS. Consistent with this observation, a heterologous nuclear export sequence (NES) abolished full-length MxB activity. We additionally mapped sub-regions within amino acids 26–90 that contribute to MxB activity, finding sequences present within residues 27–50 particularly important. Conclusions: MxB inhibits HIV-1 by interfering with minimally two steps of infection, nuclear entry and post-nuclear trafficking and/or integration, without destabilizing the inherent catalytic activity of viral preintegration complexes. Putative MxB GTPase active site residues and stalk domain Loop 4 -- both previously shown to be necessary for MxA function -- were dispensable for MxB antiviral activity. Instead, we highlight subcellular localization and a yet-determined function(s) present in the unique MxB N-terminal region to be required for HIV-1 restriction. http://www.retrovirology.com/content/11/1/90 Kenneth Matreyek Weifeng Wang Erik Serrao Parmit Singh Henry Levin Alan Engelman Retrovirology 2014, null:90 2014-10-25T00:00:00Z doi:10.1186/s12977-014-0090-z /content/figures/s12977-014-0090-z-toc.gif Retrovirology 1742-4690 ${item.volume} 90 2014-10-25T00:00:00Z XML Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein Background: Plants remain an important source of new drugs, new leads and new chemical entities. Triptolide is a diterpenoid epoxide isolated from Tripterygium wilfordii Hook F that possesses a broad range of bioactivities, including anti-inflammatory, immunosuppressive and anti-tumor properties. The antiviral activity of triptolide against human immunodeficiency virus type 1 (HIV-1) has not been reported. Results: In this study, nanomolar concentrations of triptolide were shown to potently inhibit HIV-1 replication in vitro. To identify the step(s) of the HIV-1 replication cycle affected by triptolide, time-of-addition studies, PCR analysis and direct transfection of viral genomic DNA were performed. The results of these experiments indicated that triptolide acts at the stage of viral gene transcription. In addition, a luciferase-based reporter assay that allows quantitative analysis of long terminal repeat (LTR)-driven transcription showed that Tat-induced LTR activation was impaired in the presence of triptolide. Moreover, Western blot analysis of exogenous gene expression (driven by the human elongation factor 1 α subunit promoter) in transiently transfected cells revealed that triptolide specifically reduces the steady-state level of Tat protein, without suppressing global gene expression. Further studies showed that triptolide accelerates Tat protein degradation, which can be rescued by administration of the proteasome inhibitor MG132. Mutation analysis revealed that N-terminal domains of Tat protein and nuclear localization are required for triptolide to reduce steady-state level of Tat. Conclusion: This study suggests for the first time that triptolide exerts its anti-HIV-1 activity by specifically prompting the degradation of the virally encoded Tat protein, which is a novel mechanism of action for an anti-HIV-1 compound. This compound may serve as a starting point for developing a novel HIV-1 therapeutic approach or as a basic research tool for interrogating events during viral replication. http://www.retrovirology.com/content/11/1/88 Zhitao Wan Xulin Chen Retrovirology 2014, null:88 2014-10-17T12:00:00Z doi:10.1186/s12977-014-0088-6 /content/figures/s12977-014-0088-6-toc.gif Retrovirology 1742-4690 ${item.volume} 88 2014-10-17T12:00:00Z XML Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineages Background: HIV-1 can persist for the duration of a patient's life due in part to its ability to hide from the immune system, and from antiretroviral drugs, in long-lived latent reservoirs. Latent forms of HIV-1 may also be disproportionally involved in transmission. Thus, it is important to detect and quantify latency in the HIV-1 life cycle. Results: We developed a novel molecular clock–based phylogenetic tool to investigate the prevalence of HIV-1 lineages that have experienced latency. The method removes alternative sources that may affect evolutionary rates, such as hypermutation, recombination, and selection, to reveal the contribution of generation-time effects caused by latency. Our method was able to recover latent lineages with high specificity and sensitivity, and low false discovery rates, even on relatively short branches on simulated phylogenies. Applying the tool to HIV-1 sequences from 26 patients, we show that the majority of phylogenetic lineages have been affected by generation-time effects in every patient type, whether untreated, elite controller, or under effective or failing treatment. Furthermore, we discovered extensive effects of latency in sequence data (gag, pol, and env) from reservoirs as well as in the replicating plasma population. To better understand our phylogenetic findings, we developed a dynamic model of virus-host interactions to investigate the proportion of lineages in the actively replicating population that have ever been latent. Assuming neutral evolution, our dynamic modeling showed that under most parameter conditions, it is possible for a few activated latent viruses to propagate so that in time, most HIV-1 lineages will have been latent at some time in their past. Conclusions: These results suggest that cycling in and out of latency plays a major role in the evolution of HIV-1. Thus, no aspect of HIV-1 evolution can be fully understood without considering latency - including treatment, drug resistance, immune evasion, transmission, and pathogenesis. http://www.retrovirology.com/content/11/1/81 Taina Immonen Thomas Leitner Retrovirology 2014, null:81 2014-10-16T12:00:00Z doi:10.1186/s12977-014-0081-0 /content/figures/s12977-014-0081-0-toc.gif Retrovirology 1742-4690 ${item.volume} 81 2014-10-16T12:00:00Z XML HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity Background: HIV-1 viral infectivity factor (Vif) is an essential accessory protein for HIV-1 replication. The predominant function of Vif is to counteract Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G, A3G), a potent host restriction factor that inhibits HIV-1 replication. Vif mediates the proteasomal degradation of A3G and inhibits A3G translation, thus diminishing the pool of A3G that is available to be packaged into budding virion. Although Vif is robust in degrading A3G, the protection provided against A3G is not absolute. Clinical and laboratory evidence have shown that A3G is not completely excluded from HIV-1 viral particles during HIV-1 replication. It remains unclear why the viral samples are still infectious when A3G has been packaged into the virions. Results: In this study, we provide evidence that Vif continues to protect HIV-1 from the deleterious effects of A3G, even after packaging of A3G has occurred. When equal amounts of A3G were packaged into budding virions, the virus expressing functional Vif was more infectious and incurred fewer G to A hypermutations in the second round of infection compared to Vif-deficient virus. A Vif mutant with a defect in viral packaging showed a reduced ability to protect the HIV-1 genome from G to A hypermutations. Conclusion: Our data suggest that even packaged A3G is still under the tyranny of Vif. Our work brings to light an additional caveat for any therapy that hopes to exploit the Vif-A3G axis. The ideal strategy would not only enhance A3G viral packaging, but also reduce HIV-1 Vif viral encapsidation. http://www.retrovirology.com/content/11/1/89 Yudi Wang Ballington Kinlock Qiujia Shao Tiffany Turner Bindong Liu Retrovirology 2014, null:89 2014-10-11T12:00:00Z doi:10.1186/s12977-014-0089-5 /content/figures/s12977-014-0089-5-toc.gif Retrovirology 1742-4690 ${item.volume} 89 2014-10-11T12:00:00Z XML


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Home » News » Education
Pushback against logo plan for UNH heats up
Last week, the university said it will pay about $100,000 to a New York City design firm that has prepared three possible logos. The notion is to modernize the image of UNH and distant it from the single-campus model that is implicit in the Thompson Hall logo.
Scotty Arsenault said the university should hire a local artist. "You're paying a ridiculous amount for insultingly mediocre designs. Don't limit yourselves to this shield/crest concept," he wrote.
"We need to compete nationally and internationally for students and dollars," she said.
UNH President Mark Huddleston will make the final decision on the logo, Mantz said.
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Yes, we informed liberty voters aren't the target audience 4 CNN
The Rand Haterz (at least, the ones who aren't paid trolls and operatives posing as "concerned Ron Paul supporters") don't seem to realize that TV appearances and interviews like this one aren't aimed at them. They're aimed at independents and old school Republicans like my folks, who have bought into the MSM depiction of Ron Paul as a "kook." Just last week, my dad watched a Rand sound bite on Fox News and said out loud, I'd vote for this guy in a second."
It's unfortunate that Rand can't catch a break from these alleged Liberty votes. If "Paul" wasn't his last name, they'd be salivating with glee over having such a pro-Liberty Senator. Instead of comparing him to the other 97 +/- losers in the Senate, they insist on comparing him to his dad, a one-in-a-million statesman and scholar. And if that's their criterion, they will never find Rand acceptable and will continue to cut off their noses to spite their face.
"Evil is powerless if the good are unafraid." - Ronald Reagan
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Sometimes after I finish a game my sound stops working, not just for the LOL client, but for everything else as well. When I close the LOL client, I get sound back for everything on my computer. Any ideas?
Next time you open League of Legends, alt tab out.
Go to the bottom left. Click on the volume. Hit mixer.
Change the settings so that other sounds are on par with LOL.
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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See how to make a healthy Italian-style white bean soup with fresh spinach.
In this video, you'll see how to make a healthy Italian-style white bean soup with fresh spinach. The white beans give this soup its wonderful creamy texture without any actual cream; it's a healthy, hearty soup your family will love! And starting with canned white kidney beans and chicken broth makes it easy. Watch the video, then get colleenlora's 5-star recipe for Creamy Italian White Bean Soup. Serve this hearty soup with grated Parmesan cheese. See more soup videos >>
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The Amazing Race Review: A Sad Dayby Luke Dwyer at . Comments
Watching the end of this week's leg of The Amazing Race: Unfinished Business I now know what it must feel like to have to choose between your two children: awful.
The reality that the cowboys were going to be towards the back of the pack, if not last, was evident very early after Jet messed up the Roadblock. However, we were able to dream that another team would get U-Turned as well and Jet and Cord could use their speed to make up ground, pass a team and avoid a last place finish.
As the Detour wore on, however, it became obvious that a worst case scenario was developing. The cowboys would be U-Turned, alright. But one by one each of the teams I wanted to see forced to do the other half of the challenge - Kent and Vyxsin, Kisha and Jen or Gary and Mallory – skated by the double U-Turn without doing anything.The only option which remained was U-Turning the Globetrotters. This didn't help our emotional conundrum; with the cowboys, they're the two most popular teams and we were guaranteed one would go home. It was truly a sad episode.
Flight Time and Big Easy can't be blamed for U-turning the cowboys, they had no other choice. They even commented that they didn't want to send Jet and Cord to the other challenge, but felt they had no option.
The real problem with the episode was the format of the leg. By placing the Double U-Turn last, a lot of the drama was removed from the leg. The first few teams that arrived at the Double U-Turn knew they were done with challenges, knew there were teams behind them and didn't want to make enemies when they didn't need it.
Let's hop in the time travel machine and go back to the fifth leg of the race. Remember when Flight Time and Big Easy and Jaime and Cara were both U-Turned, but each had an opportunity to come back during the Roadblock? The twist of the Roadblock after the Detour kept the leading teams uncertain of their spot and led to an earlier U-Turning. Without that pressure this week, no one needed to U-Turn.
The real tragedy this week is that a terrible team like Kent and Vyxsin go on while one of the best teams of all time, Jet and Cord, are sent home. I should clarify: Vyxsin is certainly worthy, but Kent is not.
Two weeks ago he showed us a bad side of himself and hasn't done much to redeem himself in the legs since then. This week was no exception as Kent bitched and whined his way through the Detour. The task of delivering luggage was too taxing for the skinny man. Never mind that four other women, including one team of only women and his partner, Vyxsin, all managed to complete the task without complaining.
The cherry on top (or whatever the negative version of that saying is) was Kent once again lacking any sort of pride and allowing Vyxsin to carry him in the cart at the end of the Detour. Perhaps even more confusing was her acceptance at doing so and subsequent praise of his fortitude on the challenge. Are we missing something?
In the end, we lose one of our favorite teams, Jet and Cord. Below is a quick eulogy of the cowboys.
Two time The Amazing Race runners, brothers Jet and Cord were best known by the nickname "The Cowboys" and for their signature cowboy hats. Revered for their never-say-die spirit, Jet and Cord's time on each appearance on The Amazing Race ended sooner than it should. The pair was revered for their unflappable kindness and civility, regardless of the circumstances. One of the most feared teams ever to run the race, the pair ends their The Amazing Race careers with several leg victories and countless hearts of women all over America, but no titles.
More from this episode:
- Zev absolutely killed it this week. If you need reminding, check out our quotes section.
- Is anyone else annoyed at the faux build-up that the producers like to lay on us to create drama where none exists? This week moves such as not showing us what train the cowboys got on or trying to make it seem like Jet and Cord were close to catching Flight Time and Big Easy when it was unlikely they were close. The last scenario illustrates the problem with this editing ploy: we're now jaded and don't believe what we're seeing. We'll never know if the Cowboys actually got close to Flight Time and Big Easy.
- I've been meaning to mention this for a while: Jen looks like a female version of Rajon Rondo. I'm not sure who that's more insulting to.
- Watching Zev and Justin force down the cheese fondue was really disgusting. I found it very hard to watch by the end.
I have watched AR since season 1. I am really disappointed. This season had some of my favorite teams back (minus Rob and Amber). The Cowboys played such a great game. As well as many of the teams. I like many of the remaining teams minus Kent and Vxyin (like her not crybaby him). If you are suppose to do the task how can come you don't have to figure out the answer for yourself. This has happened to the Cowboys twice. I feel it is okay to help other teams but not with the answers to a assigned task. The U-turn should not be at the end because the Cowboys had no way of recovering. Big Easy and Flight Time had no other choice. This should have been a 2 week leg so the Cowboys at least had a chance. Shame on you AR producers.
I have watched every series, every episode of the Amazing Race since it began... but now it has lost it's lustre to me. Why were Jen and Keisha not penalised for losing their map? Why can the teams get away with cheating, by giving the answers to each other?
Jet and cord have played straight and fair and in no way deserved to go home... gutted!
The Cowboys weren't given a fair deal and as such I no longer care, this show has gone downhill...not going to bother next season.
I have watched the AR since the beginning all 11 seasons. It is the ONLY reality show I watch and the only 1 I would ever want to be on but I am DONE for this season. Jet and Cord have always been polite, helpful and good sportsmen. They don't yell at their partner(Ron and Kent) or others or push people out of taxis(Kent), they play fair and never give up. I was rooting for them and Flight Time and Big Easy but with the Cowboys gone I won't watch the rest of the season because I know F.T. and B.E. are next to go. To have Gary and Mallory and Kent and Vyxsin survive with the non-elimination legs reeks especially how EASY their speedbumps were. I just can't support the rest of this season.
I think there has been too much of this sharing of the answers in this season's AR and it is totally killing the show. You are supposed to win the show through your own hard work and determination not piggy riding on someone else's work!!! I mean come on...example one...globetrotters did it last night and they also did it with the flag challenge back at the beginning...can you guys not do your own work...another time where the cowboys bucked up knew there was something missing and went back to do it right ON THEIR OWN!!!! I don't know if I can stomach watching the end of this season, truly. Jet and Cord, best team ever!!!
I agree that the Cowboys were not given a fair chance, there should be a penalty for giving out information to other teams. They should be brought back! It will absolutely make me nuts if Blondie and her Dad win, he's fine, but I want to put a sock in her mouth. Kent is Vyxin's very own triple detour. Justin and Zev are working together and hopefully make it to the final 3. Somtimes I think AR makes some very poor decisions. Like when Kent and Vyxins missed the 2 "scheduled" planes they got a penalty. What were they supposed to do? Just sit there until the race ended? Another sore point I've had was when the Chinese brother and sister won the race which ended in China,they spoke the language and had been there...can you say "unfare advantage"????
Last night's episode was disheartening. Seeing the cowboys lost when they were the only team that played fair. That is, without getting any help from the other teams that decided to gang up on them. The producers should make a rule about giving answers to other teams. Penalties should be meted! Suddenly, this race is NOT SO AMAZING anymore....
No fair! The cowboys were cheated!!! Ban The Amazing Race!!!
I have always been a fan of The Amazing Race until last night's episode when Jet and Cord got eliminated. They were the only team that played fair in the Lichtenstein challenge. Everybody else cheated including the sisters who didn't even have to go back when her map flew off of her pocket. The show should have penalized the cheaters. Not doing so is like advocating that cheating is only way you get ahead in life. Is this the message that the show wants to get across? Too bad. I really thought the show was Emmy worthy.
So sorry to see the cowboys go. That blonde chick is so damn annoying. She makes me cringe everytime she acts so goofy. She makes Phil smile but she makes me yell Shut up at my TV
i'm agreeing with everyone on here about other teams suffering a cheating penalty. the amazing race is supposed to be about teamwork, determination, and (sometimes), sheer luck. when teams regularly join forces, or all gang up against one team, the show starts to feel like survivor, where social connections and tricks are the most important thing. i don't watch survivor for that very reason, and i'm getting a little fed up with amazing race for allowing stuff like that to happen. (this is the 2nd time this season the cowboys had a hard time with a clue that everyone else shared.) the cowboys were by far my favorite team, but when you have 5 teams working against you, what chance do you have?


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B&B Noisy le Grand
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TripAdvisor Reviews B&B Noisy le Grand Noisy-le-Grand
Travel Blogs from Noisy-le-Grand
Le Chateau de Versailles
... we paid the locksmith 120 E ( about $180 Canadian) for a service call and a 90 second solution! Now we know how the locals can shop at Les Galeries Lafayette! After this experience we needed some comfort food so we tried a great Italian place on a side street for fried calamari (no batter here!) and pasta pappardelle with speck ham and mushrooms for Rick, and rigatoni with pumpkin (yes!), marscapone and speck for Ardeth. We definitely felt better after that ...
Hotel Premiere Classe & Gay Paree
... flood our cell as the shower curtain wasn't up to the job. I did my best to mop up and we got out of there a bit sharpish just in case there were complaints from the first floor guests about water coming through the ceiling. We hot footed it across the road and jumped on the 6.17 am train to Paris. The only thing we had to worry about now was if we could blag it to Paris without paying the fare. Despite the fact we'd paid for the other train we ...
Mercy auvoir
... all of who although thought the book as kind of cool did not want to buy it. They told us about a shop to go to. It again the guy did not want it. A valiant attempt I thought but no dice in paying for your trip with the proceeds of Carla's book. Across the. Remaking bridge of arts with all the locks and then a short stroll along the plages again to hop on the metro home. This was a good idea as we were kind of done with walking and pretty hot. ...
Rest Day
... late in the afternoon before heading out for dinner. Had a pre dinner drink and then walked up an alley way and settled in to an inviting restaurant. Chatted to a group of people from Oz that were fun to talk too. Checked the time and couldn't believe it was after 10 already. Shortly after, said our good byes and had a night cap on our way back to our ...
... saleswomen. A stunning,special exhibition of paintings by Van Gogh at Musee D'Orsay. Row upon row of delectable pastries,each a work of art with it's own special name. Standing in the queue,in silence,agonising over the selection. Dog droppings on the pavement. Endless art. A place of contradictions, of poverty and palaces. Best thing to do? Take the back streets and get lost. Above all,Paris is creative,inspiring and ...
Other places to stay in Noisy-le-Grand
Holiday Inn Paris Marne La Vallee2 Boulevard du Levant, Noisy-le-Grand | 3 star hotelfrom $102
Novotel Marne La Vallee Noisy2 Allee Bienvenue, Noisy-le-Grand | 4 star hotelfrom $111
Ibis Paris Marne La Vallee Noisy4, Allee Bienvenue, Noisy-le-Grand | 3 star hotelfrom $77
Premiere Classe Marne La Vallee - Noisy Le Grand9 rue de l'Universite, Noisy-le-Grand | 1 star hotelfrom $60
hotelF1 Marne la Vallee Noisy le Grand/ ChampsBoulevard du Ru de Nesle, Noisy-le-Grand | Hotelfrom $39
Kyriad MLV Noisy Le Grand5 rue du Ballon, Noisy-le-Grand | Hotelfrom $72