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If you've written your own custom attached property in WPF you may come across the following error when you try to look at a Window, Page or UserControl that attempts to use the attached property in the WPF designer in Visual Studio 2008:
The Property '[your custom attached property name]' is read-only and cannot be changed
The Property '[your custom attached property name]' is read-only and cannot be changed
The puzzling thing is that you can get this error message even if your attached property is not defined as read-only, and has a setter and isn't registered as read-only in the Property Meta-data. Even more confusingly the property can seem fine and working correctly at run-time.
So what's going on? Although the error message is a little cryptic the error is caused by a type mismatch between the property type of the dependency property (when it is registered) and the second parameter accepted by the "Set[YourPropertyName]" method that is defined when creating an attached property. For example if you've registered an attached property like this:
public static readonly DependencyProperty MyCustomProperty = DependencyProperty.RegisterAttached("MyCustom", typeof(MyOtherType), typeof(MyType));
The property meta-data system expects that when you set this attached property the value will be of MyOtherType (the second type parameter is the type that "owns" the dependency property, usually the type you declare the DP in). Type WPF designer is aware of this, for example if you attempt to assign this property in XAML from a string and no appropriate converter from string to MyOtherType is present it shows an error.
However as part of your attached property declaration you are also obliged to create "Get[PropertyName]" and "Set[PropertyName]" wrapper methods for getting and setting the attached properties.
public static void SetMyCustom(DependencyObject depObj, TheWrongType value){ depObj.SetValue(MyCustomProperty, value);}
If we include the wrong type as the second parameter in one of these declarations – in this case a type that is not assignable from MyOtherType - this isn't a compile time error (because these methods aren't part of any interface we're implementing or generic type) and may work fine at run-time if that code path isn't called (I believe that XAML bypasses the property wrappers). The designer does pick up on the discrepancy, and considers that type dependency property is read-only because it couldn't find an appropriately typed "Set[YourPropertyName]" method. Of course this error is easy to resolve once you know the cause, by changing the type of the second parameter to be the same as, or assignable from the type that was used when you declared the dependency property.
The ASP.NET repeater is a great control for creating an arbitrary templated look for lists of data in ASP.NET web applications. WPF's databinding bears a great deal of similarity to the templating support found in the repeater, taking the power of templating even further by allowing templates to be defined as resources and re-used in multiple contexts, and in lots of different types of controls. However in spite of this there is no Repeater control in WPF.
Sample Repeater (from MSDN)
<asp:Repeater id="Repeater1" runat="server"> <HeaderTemplate>

 Company	 Symbol
 </HeaderTemplate> <ItemTemplate>
  <%# DataBinder.Eval(Container.DataItem, "Name") %> 	  <%# DataBinder.Eval(Container.DataItem, "Ticker") %>
 </ItemTemplate> <FooterTemplate>
 </FooterTemplate> </asp:Repeater>
How can you replicate the functionality of the repeater in WPF? It turns out this is quite easy using an ItemsControl. ItemsControl is the base type that lots of list-like controls in WPF like ListBox, ComboBox and Menu which inherit from it either directly or indirectly. ItemsControl is also the parent to some list-like controls you might not expect such as the toolbar (which is really just a list of buttons and other controls, usually laid out horizontally) and StatusBar (once again, usually just a kind of horizontal list of controls). In spite of its fairly fundamental nature to lots of the usual suspects in the WPF controls namespace it isn't an abstract type and can be created in markup and bound like this:
ItemsControl Xaml Code
<ItemsControl ItemsSource="{Binding}"> <ItemsControl.ItemTemplate> <DataTemplate>  <TextBlock Text="{Binding}" /> </DataTemplate> </ItemsControl.ItemTemplate></ItemsControl>
The <DataTemplate> element allows us to specify how we want each item the ItemsControl is bound to, and the ItemsSource property on the ItemsControl populates the bound items from the data context (I'm assuming for the purposes of this demo that the stuff you want to bind to is in there). Another thing you may wish to do with the ItemsControl is to place it inside of a ScrollViewer control. The ASP.NET repeater generates HTML which is hosted in the browser, which handles showing a scroll-bar if the document is longer than can be displayed on a single screen. WPF Windows and Pages don't default to this way of operating, and thus you probably want to add the scroll viewer if more items are added to the ItemsControl than can be displayed inside the Window or Page.
Here is a complete page showing the list of binding modes available in WPF displayed in an ItemsControl. The ItemsControl has an ItemsPanel property that the bound items are layed out in. The default is a StackPanel, which is they type of panel you would want to reproduce the functionality of the ASP.NET Repeater. In this example below we've used the UniformGrid instead to control the layout of the items being bound. You can click here to run this page in your browser.
<Page xmlns="
" xmlns:x="
" xmlns:d="clr-namespace:System.Windows.Data;assembly=PresentationFramework" xmlns:sys="clr-namespace:System;assembly=mscorlib" > <Page.Resources> <ObjectDataProvider MethodName="GetValues" ObjectType="{x:Type sys:Enum}" x:Key="bindingNames"> <ObjectDataProvider.MethodParameters> <x:Type TypeName="d:BindingMode"/> </ObjectDataProvider.MethodParameters> </ObjectDataProvider> </Page.Resources> <ItemsControl ItemsSource="{Binding}" DataContext="{StaticResource bindingNames}"> <ItemsControl.ItemsPanel> <ItemsPanelTemplate> <UniformGrid IsItemsHost="True" /> </ItemsPanelTemplate> </ItemsControl.ItemsPanel> <ItemsControl.ItemTemplate> <DataTemplate>  <TextBlock Text="{Binding}" FontSize="22" Margin="5" Foreground="#feca00" /> </DataTemplate> </ItemsControl.ItemTemplate> </ItemsControl></Page>
When you create a WPF application in Visual Studio the 'entry point' for the process, where the application is created and the first form displayed, is not directly apparent. Instead the start-up behaviour is controlled by setting attributes on the App.xaml, such as which form to start. At compile-time WPF generates the real entry point method using the classic static void Main() method signature in C#, or Public Shared Sub Main() in VB.NET. Inside the Main() method WPF creates an instance of one of your classes which derive from System.Windows.Application, and calls the blocking Run() method on this Application-derived class which keeps the process "alive". Generally this is a useful abstraction, hiding away some of the lower-level details of how the WPF application starts up, however sometimes you want to provide your own version of the Main() method. So how do you tell WPF to use your main method and not its own?
The way WPF knows to create the Main() method for a particular xaml file is through the build action property set for App.xaml - it has a build action of ApplicationDefinition. By changing this to Page WPF won't create the Main method and you can provide your own in a regular class file you add to the project.
It is important to note that when you provide your own Main() method that the method should be adorned with the STAThread attribute, which sets the threading model for the process. You can either look at the current generated Main() method for your project as a starting point (it should be in the obj folder) or use the following code:
[System.STAThreadAttribute()]static void Main(){ YourApplicationName app = new YourApplicationName(); app.InitializeComponent(); app.Run();}
Visual Studio 2008 comes with some useful snippets for WPF development out of the box. In C# type propa followed by two TAB keystrokes inserts the a snippet for an attached dependency property, including a getter, setter and the registration code.
Similarly propdp followed by two TAB keystrokes inserts a snippet for a dependency property. As you would expect the snippet for this is very similar to the attached dependency property, except in this case it calls DependencyProperty.Register() instead of DependencyProperty.RegisterAttached().
Visual Basic in Visual Studio 2008 has even more snippets defined including RoutedCommand and RoutedEvent registration snippets, and a RoutedCommand handler snippet. I'm primarily a C# kind of guy, so I never realized that VB.NET had the two snippets I mentioned above for C# in VS2005 (with the VS Extensions for .NET 3.0 installed). It seems in this case C# is playing catch-up to VB.NET.
You can look at all the snippets (not just the WPF-specific ones) by selecting "Tools->Code Snippet Manager" from the VS menu. You can of course define your own snippets, but it is nice to see these ones built in to VS2008.
One thing people often ask me about WPF is the learning curve - how long will it take for me to be productive, and how long before I know the "whole api". The sad fact is that knowing the "whole" of WPF is a difficult proposition, due to its size. A lot has been written about the learning curve associated with the XAML programming model and the vector-based retained rendering system, but regardless of these factors WPF is going to have a learning curve due just to its size. WPF is big by any standard - with almost 1600 public types in v3.0 and almost 3600 classes it is approximately the same size as Windows Forms and ASP.NET combined. It spans 3 main assemblies PresentationCore.dll, PresentationFramework.dll and WindowsBase.dll (I'm excluding the Aero, Classic, Luna and Royale "theme" assemblies, and the UI automation and ReachFramework in my calculation of the size since they are not WPF specific). The good news is that you don't need to know the "whole api" in order to be productive and start using WPF. Here's a helpful infographic to convey the message:
Visual Studio 2008 and .NET Framework 3.5 were released earlier this week. Visual Studio 2008 is the first version of Visual Studio released since WPF and the rest of .NET Framework 3.0 were released a year ago. VS2008 includes a WPF designer and XAML editor, and allows targeting of .NET 3.0 or .NET 3.5 when developing and compiling solutions.
.NET Framework 3.5 includes a host of new language features for C# 3.0 and VB9. Most of these language features exist primarily to support LINQ, however .NET 3.5 also includes some enhancements to WPF. An overview of the changes in 3.5 can be found here on MSDN. Kevin Moore also recorded an interview for Channel9 before he left Microsoft discussing some of the changes that were coming in 3.5. Dr Tim Sneath also listed off 15 of his favourite enhancements to WPF here.
Some of my favourite enhancements for WPF in .NET 3.5 are supporting XBAP applications in FireFox (on versions of Windows) and the data binding and IErrorProvider enhancements (thanks in part to Paul Stovell).
WPF's InkCanvas control provides a quick and easy way to add ink input to your application. By default the strokes in the InkCanvas are thin black lines, which may be too thin or difficult to see in some instances. Fortunately the appearance of the strokes can easily be changed by modifying the DefaultDrawingAttributes property of the InkCanvas which is of type DrawingAttributes.
<InkCanvas> <InkCanvas.DefaultDrawingAttributes> <DrawingAttributes Color="Red" Width="5" /> </InkCanvas.DefaultDrawingAttributes></InkCanvas>
The DrawingAttributes has a number of other interesting properties, such as the FitToCurve property which makes lines drawn in the canvas smoother. It is set to false by default. This property seems to have less of an effect when using a tablet input device. When "drawing" with the mouse you can notice the difference more easily.
Setting the IsHighlighter property to true causes the strokes to be drawn semi-transparently to allow content behind them to show through.
The IgnorePressure property defaults to false and uses pressure information from devices capable of sending it (like input tablets) to alter the thickness of the line.
You can also set the shape of the stylus tip to rectangular or elliptical by setting the StylusTip property.
For some kinds of applications displaying as "maximised" is not enough, either because they want to make use of every single pixel of screen-space possible, or because displaying the task bar and associated window trimmings would be distracting or confusing for users of the application. The PowerPoint slide viewer is a good example of this, starting in "kiosk" mode to create a more immersive presentation and preventing audience members becoming distracted by the task bar and things in the notification area. Fortunately doing this for your own WPF application can be achieved quite easily by setting the WindowStyle and WindowState properties on the Window as shown below.
Xaml Code
<Window x:Class="LearnWPF.KioskMode.Window1" xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation" xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml" Title="LearnWPF.KioskMode" WindowStyle="None" WindowState="Maximized">
WindowStyle should be set to None (this draws the window without any border, and is the same state you can use to create a WPF splash screen) and the WindowState set to Maximized. These properties can also be set from code. One small issue we have observed is if you try to change the WindowStyle in code after the WindowState has changed to Maximized the resulting window will be drawn without a border, but won't display over the top of the status bar.
If you're from further down the developer end of the designer-developer spectrum chances are you've been avoiding creating your own images, and on the look-out for some good XAML icons and vector images to include in your application, since bitmap images often look blurry. While we included some XAML image resources in the past there are plenty of other good resources out on the web if you know what to look for. Although no graphic designers are sitting at home churning out XAML code per-se, there are plenty of ways to convert the vector content they produce (like SVG files or Adobe Illustrator .ai files) to XAML. Here we've included two sites to get you started, and approaches for converting other vector formats into XAML.
is a repository of "open source" vector art stored in SVG format. SVG is an XML-based vector format (and thus you could transform it yourself to XAML if you wished), however there is already an excellent tool from Andrej Benedik from WPF-graphics.com for doing this. You can also use the free and open-source InkScape editor to edit SVG files. Many of the images are licensed in the public domain, meaning you can use them for pretty much any purpose. Shown below is a mac-like SVG image of a new computer by "big red smile" (possibly not their real name) beside the converted XAML version displayed in Kaxaml.
is a "free vector art of the day" type site, with nice vector backgrounds and images released under a variety of terms (so make sure you check the license on the image). Most of the files here are Adobe Illustrator .ai files. If you have Illustrator installed you can use Mike Swanson's exporter, however if you're a developer that is less likely. Expression Design (now included in MSDN universal) can import Illustrator .ai files. For some reason it can't open them directly (if you select File->Open and then try to browse for a .ai file it won't let you) so you need to create a new blank file, and then select File->Import and browse for the .au file. Once in Expression Design you select File->Export and select Xaml as the type from the dropdown list. You can then choose how the xaml is formed when you export it.
.NET applications traditionally suffer from slower startup time than native applications, caused by the time to load the .NET framework DLLs, JIT time etc. WPF applications have further things that can slow down cold start-time, the extra PresentationCore, PresentationFramework and WindowBase assemblies that need to be loaded and the start-up of the PresentationFontCache service. Any tips to help improve start time is therefore most welcome.
Doug Stockwell recently released an updated version (v1.6 build 2802) of his free RikReader WPF-based RSS Reader, with considerably-improved start time. I've been using RikReader as my primary RSS reader since it was first released, and in previous versions the start time stood out as a blemish on an otherwise excellent app. The performance characteristics of older versions of RikReader were a little different to usual applications, in that the hot start-times were still quite bad (>10 seconds for my list of a couple of hundred feeds), whereas the new version hot-starts in about 4 seconds (roughly equivalent to Expression Blend, Thoughtex and most other WPF applications I use). Cold start-times for RikReader had also improved noticeably.
I contacted Doug to find out what he'd done to achieve this great improvement, and was pleased to hear of the simple change he had made. Instead of using XAML to declaratively set the DataContext for his main window, which contained all the RSS feed data, he switched to setting it programmatically in the Application.OnActivated. This sounds like a tip that would improve the perceived performance of the app (making the main window display more quickly) without improving the actual performance, however it seems to have also improved the actual start time considerably. As with all things performance-related your mileage may vary, and it pays to measure yourself. Fortunately the simplicity of this change means it will be easy to swap between the two methods of setting the DataContext.


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Actor, Comedian, Writer - Home
Thanks for visiting!
Welcome to the website of actor, comedian, and writer Peter Sers. We are very busy so far this year! 2014 Has already seen Peter in SF, Reno, Boise, Phoenix, Denver, Vegas, and of course LA! And rumor has it, there's a pilot in the works. Shhhh...
NEWS: Webseries-"Casting Nightmares" now on You Tube.
Short Film-"My Blue Heart" currently in pre-production
I am also now a contributing writer for Dodgers Beat.(www.dodgersbeat.com, Facebook/dodgersbeat, Twitter@dodgersbeat)
Also look for me doing my stand up in a city near you!
Las Vegas, San Francisco, San Diego, Salt Lake City, Atlanta, New York, Chicago, Denver, more cities TBA...
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It is a 5km run - it's you against the clock.
Every Saturday at 9:00am.
It's run in Roundshaw Downs - off Purley Way, Croydon. See Course page for more details.
Nothing - it's free! but please register before your first run. Only ever register with parkrun once. Don't forget to bring a printed copy of your barcode (request a reminder). If you forget it, you won't get a time.
We all run for our own enjoyment. Please come along and join in whatever your pace!
It is entirely organised by volunteers - email email@example.com to help.
Every week we grab a post parkrun coffee at the very friendly LA Fitness Cafe nearby.
Annette HELLIWELL • Chris PHELAN • George Christopher CURTIS • Laura FOSTER • Martin LLOYD • Michael Joseph LARKIN • Mick TURNER • Nikki TARRANT • Paul David COOPER • Tim GRAY • Tony GALLAGHER • Yan HUA
Roundshaw Downs parkrun takes place
every Saturday
at 9:00am


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Explaining the persistence of violence, sectarianism, and incompetence.
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Sunni-Shiite hatreds are the least of the Middle East's problems -- it's the struggle within the Sunni world that will define the region for years to come.
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text: Forbidden Zone: The Mystery of the Bigfoot By The P! Company Join intrepid Brit, Nigel Winthorne, as he takes us into the throes of the unknown in... more »Join intrepid Brit, Nigel Winthorne, as he takes us into the throes of the unknown in his hit BBC reality series, the Forbidden Zone. In this week's episode, Nigel Winthorne and his team are hot on the trail of Bigfoot. Call him what you will- sasquatch, yeti, skunk ape, abominable snowman, ape-man, Harry from "Harry and the Hendersons"- this creature is indeed the world's most dangerous game (in a hunting sense- you know, because they are very rare). -- a P! Company Sketch www.thepcompany.com « less Published January 27, 2011 180 views More Info » Full Credits The P! Company Uploader Stats & Data 3 Funny Votes 3 Die Votes 177 Views Published January 27, 2011 Categories: Sketch Parody Nostalgia Keywords: yeti skunk ape abominable snowman ape-man Harry george noory art bell whitley streiber bigfoot sasquatch coast to coast am comedy funny sketch company thepcompany.com nerds Up Next: Grouplove - Borderlines & Aliens AUTOPLAY Up Next In: 10 Boston Movie Trailer Herman Cain's Campaign Promises with Mike Tyson Zach Galifianakis on Physical Comedy David Blaine Street Magic 2 Follow Facebook Twitter Tumblr Instagram Advertisement Browse Related Comments 3+ more View All ▶ The P! Company Vaguely Related Videos Vaguely RelatedPics & Words Advertisement From Around the Web ZergNet


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Graphic Design InternshipBookmark This
Semprove, Inc.
DescriptionWe are looking for a talented Graphic Design Intern to join our team. This position will focus on developing banners, infographics, etc. for our family of websites focused on sexual health and has high-growth potential, for the right candidate. This is likely a part-time position, but may develop into a full-time internship, in our Mountain View, CA office, and may be open for telecommuting, at least partially.
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Joy Behar condemned a political ad by Nevada Republican Senate nominee Sharron Angle as fomenting racial divisiveness. The View aired Angle's latest TV ad on the talk show on Tuesday morning. Looking at the camera, Behar addressed Angle, calling her READ FULL STORY
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The View returned again to last Thursday's argument with Bill O'Reilly that resulted in walk-offs by Whoopi Goldberg and Joy Behar. On Monday's show, they explained their motivations for the dramatic exits. "We talk about standing up to bigotry, so I stood up," said Behar. "I had had enough," said Goldberg. "I was gonna cuss him out."
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Joaquin Phoenix returned to Late Show With David Letterman on Wednesday night for the first time since his February 2009 appearance. Last night, Letterman described Phoenix as "the dope in the beard" and "a side of beef in a suit."
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Priceline to buy OpenTable restaurant reservation website
OpenTable seats more than 15 million diners per month at more than 31,000 restaurants.
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Press release from PR Newswire
Regeneron Reports Third Quarter 2010 Financial Results and Business Highlights
Thursday, October 28, 2010
Regeneron Reports Third Quarter 2010 Financial Results and Business Highlights07:00 EDT Thursday, October 28, 2010TARRYTOWN, N.Y., Oct. 28 /PRNewswire-FirstCall/ -- Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) today announced financial results for the third quarter of 2010 and provided current business highlights. Current Business HighlightsPublic Offering of Common StockIn October 2010, the Company completed a public offering of 6,325,000 shares of Common Stock and received net proceeds of approximately $174.7 million. Extension of Technology Licensing Agreement with AstellasIn July 2010, Astellas Pharma extended through 2023 the non-exclusive license agreement that allows Astellas to utilize Regeneron's VelocImmune® technology in its internal research programs to discover fully human monoclonal antibody product candidates. Astellas made a $165.0 million up-front payment to the Company in August 2010 and will make another $130.0 million payment in June 2018 unless it terminates the agreement prior to that date. Upon commercialization of any antibody products discovered utilizing VelocImmune®, Astellas will pay the Company a mid-single-digit royalty on product sales.VEGF Trap-Eye ? Ophthalmologic DiseasesInitial data from two Phase 3 studies (VIEW 1 and VIEW 2) evaluating VEGF Trap-Eye (aflibercept ophthalmic solution) in patients with the neovascular form of age-related macular degeneration (wet AMD) are expected in the fourth quarter of 2010. In addition, two Phase 3 studies (COPERNICUS and GALILEO) of VEGF Trap-Eye in central retinal vein occlusion (CRVO) are fully enrolled, and initial data from these studies are anticipated in the first half of 2011. One-year results from a Phase 2 study (DA VINCI) in patients with clinically significant diabetic macular edema (DME) will be available in the fourth quarter of 2010. In February 2010, the Company reported a statistically significant improvement in visual acuity compared to focal laser therapy over the initial 24 weeks of treatment, the primary endpoint of the study.VEGF Trap-Eye is being developed by Regeneron in collaboration with Bayer HealthCare. Bayer HealthCare has rights to market VEGF Trap-Eye outside the United States, where the companies will share equally in profits from any future sales of VEGF Trap-Eye. Regeneron maintains exclusive rights to VEGF Trap-Eye in the United States. ARCALYST® (rilonacept) ? CAPSNet product sales of ARCALYST® Injection for Subcutaneous Use in the third quarter of 2010 were $4.9 million, compared to $5.0 million during the same period of 2009. The Company recognized $20.0 million of net product sales during the first nine months of 2010, which included $15.2 million of ARCALYST® net product sales made during the first nine months of 2010 and $4.8 million of previously deferred net product sales. In the first nine months of 2009, the Company recognized $13.4 million of ARCALYST® net product sales. ARCALYST® is available for prescription in the United States for the treatment of Cryopyrin-Associated Periodic Syndromes (CAPS), including Familial Cold Auto-inflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS) in adults and children 12 and older. ARCALYST® is a fusion protein that blocks the cytokine interleukin-1 (IL-1). CAPS is a group of rare, inherited, auto-inflammatory conditions characterized by life-long, recurrent symptoms of rash, fever/chills, joint pain, eye redness/pain, and fatigue. ARCALYST® (rilonacept) ? GoutARCALYST® is in a Phase 3 clinical development program for the prevention of gout flares in patients initiating uric acid-lowering therapy. In June 2010, the Company announced positive efficacy and safety results from a Phase 3 study (PRE-SURGE 1) in gout patients initiating allopurinol therapy to lower their uric acid levels. There are two other ongoing studies in the Phase 3 program. The global PRE-SURGE 2 study, which has a similar trial design as PRE-SURGE 1, is evaluating the number of gout flares per patient over the first 16 weeks of initiation of allopurinol therapy. The global RE-SURGE study is evaluating the safety of ARCALYST® versus placebo over 16 weeks in patients who are at risk for gout flares because they are taking uric acid-lowering drug treatment. PRE-SURGE 2 and RE-SURGE are fully enrolled, and the Company expects to have initial data from both studies by early 2011. Regeneron owns worldwide rights to ARCALYST®. Aflibercept (VEGF Trap) ? OncologyAflibercept (VEGF Trap) is being developed worldwide by Regeneron and its collaborator, sanofi-aventis, for the potential treatment of solid tumors. Three randomized, double-blind, Phase 3 trials, all of which are fully enrolled, are evaluating combinations of standard chemotherapy regimens with either aflibercept or placebo for the treatment of cancer. One trial (VELOUR) is evaluating aflibercept as a 2nd-line treatment for metastatic colorectal cancer in combination with FOLFIRI (folinic acid [leucovorin], 5-fluorouracil, and irinotecan). A second trial (VITAL) is evaluating aflibercept as a 2nd-line treatment for locally advanced or metastatic non-small cell lung cancer in combination with docetaxel. The third trial (VENICE) is evaluating aflibercept as a 1st-line treatment for metastatic castration-resistant prostate cancer in combination with docetaxel/prednisone. In September 2010, Regeneron and sanofi-aventis announced that, following a planned interim analysis, the Independent Data Monitoring Committee (IDMC) for the VELOUR study recommended that the study continue to completion as planned, with no modifications due to efficacy or safety concerns. An IDMC is a body of independent clinical and statistical experts that meets periodically to evaluate study data. Based on projected event rates, final results from the VITAL study are anticipated in the first half of 2011 and from the VELOUR study in the second half of 2011. Based on projected event rates, an interim analysis of the VENICE study is expected to be conducted by an IDMC in mid-2011, with final results anticipated in 2012. In addition, a randomized Phase 2 study (AFFIRM) is evaluating aflibercept as a 1st-line treatment for metastatic colorectal cancer in combination with FOLFOX (folinic acid [leucovorin], 5-fluorouracil, and oxaliplatin). The AFFIRM study is fully enrolled, and initial data are anticipated in the second half of 2011. Monoclonal AntibodiesSince 2007, Regeneron and sanofi-aventis have collaborated on the discovery, development, and commercialization of fully human monoclonal antibodies generated by Regeneron using its VelocImmune® technology. During the fourth quarter of 2009, Regeneron and sanofi-aventis expanded and extended their collaboration with the objective to advance an average of four to five antibodies into clinical development each year between 2010 and 2017. The following antibody candidates are being developed under the collaboration: REGN727, an antibody to PCSK9, a novel target for LDL cholesterol reduction, is in Phase 1 studies using both intravenous and subcutaneous routes of administration. REGN727 is being studied as a single agent and in combination with statin therapy. A Phase 2 program is expected to begin in the first half of 2011. REGN88, an antibody to the interleukin-6 receptor (IL-6R), is in a Phase 2/3 study in rheumatoid arthritis and a Phase 2 study in ankylosing spondylitis, a form of arthritis that primarily affects the spine. Both studies are enrolling patients.REGN421, an antibody to Delta-like ligand-4 (Dll4), a novel anti-angiogenesis target, is in a Phase 1 study in patients with advanced malignancies. REGN668, an antibody to the interleukin-4 receptor (IL-4R), a target for allergic and immune conditions, has completed Phase 1 testing in healthy volunteers and will be entering a Phase 2 study in patients with atopic dermatitis in the fourth quarter of 2010.REGN475, an antibody to nerve growth factor (NGF), is being evaluated in Phase 2 studies in osteoarthritis of the knee and other pain indications. At the request of the FDA, another pharmaceutical company has suspended its anti-NGF antibody clinical program in osteoarthritis and certain other chronic pain indications. Regeneron has responded to FDA requests for information about patients in the Company's REGN475 clinical trials. REGN475 is currently not on clinical hold, and the Company's Phase 2 trials in patients with vertebral fracture pain and chronic pancreatitis pain are ongoing. The Company's Phase 2 trial in osteoarthritis of the knee has been completed. REGN910 is an antibody to angiopoietin-2 (ANG2), a novel angiogenesis target. An Investigational New Drug Application (IND) for REGN910 in the oncology setting is expected to be filed by the end of 2010. We plan to initiate clinical trials with two additional antibodies by the end of the year, REGN846 and REGN728.Financial ResultsThe Company's total revenues decreased to $106.0 million in the third quarter of 2010 from $117.5 million in the same quarter of 2009, primarily due to the receipt of a $20.0 million substantive milestone payment from Bayer HealthCare in the third quarter of 2009, partly offset by higher collaboration revenue in the third quarter of 2010 in connection with the Company's antibody collaboration with sanofi-aventis. Total revenues increased to $325.4 million for the first nine months of 2010 from $282.5 million for the same period of 2009, primarily due to higher collaboration revenue in 2010 in connection with the Company's antibody collaboration with sanofi-aventis, partly offset by the receipt of the $20.0 million substantive milestone payment from Bayer HealthCare in 2009. The Company's total operating expenses increased to $138.1 million in the third quarter of 2010 from $118.7 million in the same quarter of 2009, and to $410.1 million for the first nine months of 2010 from $317.2 million for the same period of 2009, primarily due to higher research and development expenses in connection with the Company's higher employee headcount and expanding research and development activities in 2010, principally in connection with the sanofi-aventis antibody collaboration. The Company had a net loss of $33.9 million, or $0.41 per share (basic and diluted), for the third quarter of 2010 compared with a net loss of $1.0 million, or $0.01 per share (basic and diluted), for the third quarter of 2009. The Company had a net loss of $89.9 million, or $1.10 per share (basic and diluted), for the nine months ended September 30, 2010 compared with a net loss of $31.3 million, or $0.39 per share (basic and diluted), for the same period in 2009. At September 30, 2010, cash, restricted cash, and marketable securities totaled $520.4 million compared with $390.0 million at December 31, 2009. Cash, restricted cash, and marketable securities at the end of the third quarter of 2010 included the $165.0 million up-front payment received in August 2010 from Astellas, as described above. Regeneron currently estimates that year-end 2010 cash, restricted cash, and marketable securities, including the net proceeds of the Company's public offering, as described above, will total $600 - $620 million.About Regeneron PharmaceuticalsRegeneron is a fully integrated biopharmaceutical company that discovers, develops, and commercializes medicines for the treatment of serious medical conditions. In addition to ARCALYST® (rilonacept) Injection for Subcutaneous Use, its first commercialized product, Regeneron has therapeutic candidates in Phase 3 clinical trials for the potential treatment of gout, diseases of the eye (wet age-related macular degeneration and central retinal vein occlusion), and certain cancers. Additional therapeutic candidates developed from proprietary Regeneron technologies for creating fully human monoclonal antibodies are in earlier stage development programs in rheumatoid arthritis and other inflammatory conditions, pain, cholesterol reduction, allergic and immune conditions, and cancer. Additional information about Regeneron and recent news releases are available on Regeneron's web site at www.regeneron.com.This news release discusses historical information and includes forward-looking statements about Regeneron and its products, development programs, finances, and business, all of which involve a number of risks and uncertainties. These include, among others, risks and timing associated with preclinical and clinical development of Regeneron's drug candidates, determinations by regulatory and administrative governmental authorities which may delay or restrict Regeneron's ability to continue to develop or commercialize its product and drug candidates, competing drugs that are superior to Regeneron's product and drug candidates, uncertainty of market acceptance of Regeneron's product and drug candidates, unanticipated expenses, the availability and cost of capital, the costs of developing, producing, and selling products, the potential for any collaboration agreement, including Regeneron's agreements with the sanofi-aventis Group and Bayer HealthCare, to be canceled or terminated without any product success, and risks associated with third party intellectual property. A more complete description of these and other material risks can be found in Regeneron's filings with the United States Securities and Exchange Commission (SEC), including its Form 10-K for the year ended December 31, 2009 and Form 10-Q for the quarter ended September 30, 2010. Regeneron does not undertake any obligation to update publicly any forward-looking statement, whether as a result of new information, future events, or otherwise, unless required by law.REGENERON PHARMACEUTICALS, INC. CONDENSED BALANCE SHEETS (Unaudited)(In thousands)September 30, December 31,20102009ASSETSCash, restricted cash, and marketable securities$520,409$390,010Receivables82,28765,568Property, plant, and equipment, net318,498259,676Other assets21,23925,948Total assets$942,433$741,202LIABILITIES AND STOCKHOLDERS' EQUITYAccounts payable, accrued expenses, and other liabilities$80,265$52,990Deferred revenue355,088182,428Facility lease obligations159,016109,022Stockholders' equity348,064396,762Total liabilities and stockholders' equity$942,433$741,202REGENERON PHARMACEUTICALS, INC.CONDENSED STATEMENTS OF OPERATIONS (Unaudited)(In thousands, except per share data)For the three monthsFor the nine monthsended September 30,ended September 30,2010200920102009RevenuesCollaboration revenue$89,344$100,689$269,678$233,875Technology licensing10,03710,00030,11230,000Net product sales4,9364,97319,98513,364Contract research and other1,6621,7935,6245,229105,979117,455325,399282,468ExpensesResearch and development 122,043105,434364,040279,972Selling, general, and administrative15,65812,84044,56035,892Cost of goods sold3724721,4941,299138,073118,746410,094317,163Loss from operations(32,094)(1,291)(84,695)(34,695)Other income (expense)Investment income4538571,4843,935Interest expense(2,234)(581)(6,660)(581)(1,781)276(5,176)3,354Net loss$ (33,875)$ (1,015)$ (89,871)$ (31,341)Net loss per share amounts, basic and diluted$ (0.41)$ (0.01)$ (1.10)$ (0.39)Weighted average shares outstanding, basic and diluted81,63879,86681,43379,663Contacts Information:Michael Aberman, M.D.Peter DworkinInvestor RelationsCorporate email@example.com@regeneron.comSOURCE Regeneron Pharmaceuticals, Inc.For further information: Michael Aberman, M.D., Investor Relations, +1-914-345-7799, firstname.lastname@example.com, or Peter Dworkin, Corporate Communications, +1-914-345-7640, firstname.lastname@example.com


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Rant Sports Week 8 Official College Basketball Top 25 Rankings
Top 25 Rankings
Conference play is almost here. There have been many players who have gotten off to amazing starts and there have been many teams that have done the same. I am sure less players will put up huge numbers once conference play does actually begin, but that remains to be seen. Regardless, let's take a look at the Week 8 college basketball top 25 rankings.
No team in the top five lost, which means the top five will not look any different. There is, however, a lot of change outside of the top 10. That tends to happen when ranked teams beat each other and when other teams pull off upsets.
Texas got a huge win over North Carolina, but ended up losing to Michigan State in the very next game. Still, the Longhorns will be joining the top 25 thanks to their fast start. Up until this point, they have been underrated to say the least.
Wichita State has passed every test so far and remains undefeated. There are still plenty of other undefeated teams, but the Shockers have a legit shot at going undefeated this season. That is because they play in a weaker conference that no longer has the Creighton Bluejays. Plus, Wichita State is one of the best teams in the country.
Jabari Parker and the Duke Blue Devils have been impressive as of late and the same thing can be said about the full strength Florida Gators, who will finally have Chris Walker back here shortly.
Well, check out the latest edition of the college basketball top 25 rankings for Week 8.
If you're a tweeter feel free to follow me @TheTrevorLowry or add me to your network on Google.
25. Missouri Tigers
The Missouri Tigers were handed their first loss of the season, but it was against an underrated Illinois team by one point. Still, the Tigers have been great so far and should challenge for an SEC title.
24. Iowa Hawkeyes
Iowa may have two losses, but both came against very good teams. Watch out for this team once Big Ten play starts.
23. Texas Longhorns
Texas was one of the hottest teams in the nation before losing to Michigan State. Still, it managed to beat North Carolina by three points in the game before that.
22. Massachusetts Minutemen
Massachusetts finally lost and that loss came against Florida State. The Seminoles have surprisingly been a very good team, so this is not a bad loss or anything like that.
21. Colorado Buffaloes
It would not surprise me if the Colorado Buffaloes made a run to the Final Four this year. That is how much talent they have, but they will have to go through a tough Pac-12 Conference first.
20. Memphis Tigers
Memphis had one the most talented backcourts coming into the 2013-14 college basketball season and that has been evident so far.
19. San Diego State Aztecs
San Diego State continues to win, as it is on an eight-game winning streak. Kansas is soon, so it will be interesting to see if the Aztecs can come away with the victory.
18. North Carolina Tar Heels
P.J. Hairston no longer being on the team or not, North Carolina can finally move on and worry about the players who are actually on the court.
17. Kansas Jayhawks
Kansas has quietly beaten two solid opponents ever since dropping two straight. The Jayhawks' last two victories have come against New Mexico and Georgetown.
16. Kentucky Wildcats
Kentucky will play Louisville next and it really could use a win against a team that is actually ranked. A win for the Wildcats would give this young and talented team some much needed confidence and would have them back in the conversation for a national title.
15. Florida Gators
The Florida Gators could be the best team in the nation, yet they come in at No. 15. That is because they already have two losses--against two ranked opponents--but they have beaten two top 20 teams in the past two games.
14. Baylor Bears
Baylor may have missed out on the NCAA tournament last season, but that should definitely not be the case this year. The Bears have been challenged in their non-conference schedule, which means they should be more than ready for Big 12 play.
13. Iowa State Cyclones
Iowa State recorded another quality win by knocking off Boise State on Christmas. No, the Broncos were not ranked coming into that game, but they are expected to challenge for a MWC title.
12. Connecticut Huskies
The Huskies lost their first game of the season by two points against Stanford. They followed that up with a victory against Washington.
11. Villanova Wildcats
Villanova has the chance to beat its second top five team of the season when it takes on Syracuse on Dec. 28. The Wildcats will move all the way up to the top five if they can pull off the victory.
10. Oregon Ducks
Oregon continues to win and it also continues to have the highest scoring offense in college hoops.
9. Wichita State Shockers
I am not sure when the Wichita State Shockers will lose, but I wouldn't mind seeing them going undefeated this season.
8. Duke Blue Devils
Jabari Parker is the best player in the nation right now. As a result, the Duke Blue Devils are one of the best teams, which they proved by knocking off another solid opponent in the UCLA Bruins.
7. Louisville Cardinals
Louisville has been very quiet this season. Well, the Cardinals will play Kentucky next, so that could change very soon.
6. Oklahoma State Cowboys
Oklahoma State knocked off a very good Colorado team, which means it has now beaten two ranked opponents. The Cowboys should be the team to beat entering Big 12 play.
5. Michigan State Spartans
Michigan State may have lost to North Carolina, who lost to Texas, but it managed to beat the Longhorns. Quite the love triangle or whatever you want to call it right there.
4. Wisconsin Badgers
The Wisconsin Badgers should take their undefeated record into conference play. First up will be the Northwestern Wildcats, but Wisconsin has one more game before that can happen.
3. Ohio State Buckeyes
Just like Wisconsin, the Ohio State Buckeyes should be undefeated when Big Ten play starts. And just like Wisconsin, Ohio State has one more game before that can happen.
2. Syracuse Orange
Syracuse has been great so far, but beating the undefeated Villanova Wildcats would be the cherry on top. At least for the time being.
1. Arizona Wildcats
Arizona will enter Pac-12 play undefeated once again. This year, however, it should only lose a couple of games in the conference.
This is the No. 1 team in the country and it is the favorite--by far--to win the Pac-12.
Iowa State vs. Alabama: Game Preview, Prediction
The Iowa State Cyclones look to start the season 4-0 when they face Alabama in the Hall of Fame Classic. Who comes out on top? Find out here. Read More
BYU vs. San Diego State Game Preview, Prediction
The BYU Cougars and San Diego State Aztecs face off in a matchup of NCAA Tournament sleepers. Who will come out on top in the Maui Invitational? Find out here. Read More
Oregon vs. Michigan Game Preview, Prediction
The Oregon Ducks and Michigan Wolverines are two potential 2015 NCAA Tournament teams. Their early season match-p is crucial to their eventual tournament hopes. Find out more here. Read More
Villanova vs. VCU: Game Preview, Prediction
The Villanova Wildcats take on the VCU Rams in a top 15 showdown in the Progressive Legends Classic. Who will come out on top? Find out here. Read More
Missouri vs. Arizona: Game Preview, Prediction
The Arizona Wildcats look to stay undefeated as they face the rebuilding Missouri Tigers. Who will come out on top? Find out here. Read More
Calipari Wishes Daughter Happy B-day On Wrong Day
John Calipari accidentally wished his daughter a happy birthday on the wrong day. Read More
5 Bold Predictions For Oregon vs. Michigan
Michigan basketball should beat a talented but young Oregon team in Barclays Center to clinch a Legends Classic Final matchup with VCU or Villanova. Read More
Top 5 Players in A 10 Entering 2014-15 CBB Season
The 2014-15 college basketball season is underway, and these five players are the best that the Atlantic 10 conference has to offer. Read More
Given 4 Years, Could Kentucky Make NBA Playoffs?
After Kentucky dominated Kansas 72-40, the internet wondered if UK could beat the 0-11 76ers. But why not focus on a more important, pointless, question? Could Kentucky make it to the NBA Playoffs? Read More
Top 10 Frontcourts In College Basketball
These 10 frontcourts are the best in college basketball this season. Read More
Top 10 Duos In College Basketball In 2014-15
These 10 duos are the best in college basketball for the 2014-15 season. Read More
Kam Williams Could Be Key For Ohio State
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Texas Tech Takes Over Stewardship of International Journal of Hispanic Media
Regents professor Kenton Wilkinson was named as the publication's editor.
The Thomas Jay Harris Institute for Hispanic and International Communication (HIHIC) in the College of Media & Communication at Texas Tech University has taken over stewardship of the International Journal of Hispanic Media, publishing its first issue this month.
Formerly known as the Journal of Spanish Language Media, Texas Tech assumed control from the University of North Texas' Center for Spanish Language Media, which published the journal for the last six years. Kenton T. Wilkinson, the Thomas Jay Harris Regents Professor in Hispanic and International Communication, was named the publication's editor.
"Sponsorship of the journal raises the research profile of both the institute and the College of Media & Communication," Wilkinson said. "Having the journal based here complements the collaborative and individual research activities being pursued by faculty and student affiliates of the institute."
Wilkinson said the name of the journal was changed to be more inclusive to bilingual and English-language media directed toward Hispanic audiences in the U.S. while maintaining an international focus. He hopes to publish articles that show a broad range of research methods and quality research to promote Hispanic media.


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