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This is 5 Miles Of Meat, 350,000 Grams Of Protein….
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An investigation by The Day found more than a half-dozen instances across the state in which property owners facing foreclosure believe they were misled by a scheme run by a man convicted of similar illegal activitiy in New Jersey in 2003.
Hospitals statewide have been directed by Gov. Dannel P. Malloy to conduct Ebola preparedness drills within the next seven days and preferably within the next 48 hours, and a Unified Command Team of state officials has been formed to coordinate resources...
Capt. Charles T. Senay steadied his Springfield rifle, aimed at the machine-gun-wielding German moving toward him, and fired. The bullet sailed high into the air.
A sparkling display of fireworks that lasted about 20 minutes evoked cheers and set off car alarms Saturday during Sailfest.
An incident last Friday not only changed Haley Barravecchia's graduation speech at Stonington High School Thursday but also her outlook on life.
When work began in November of 2008 on what would become a multimillion-dollar project to restore the whaling ship Charles W. Morgan, there were no plans to sail her again.
Just 10 years ago, heroin made up a small fraction of the drug-related arrests in Norwich. These days, Detective Lt. Mark Rankowitz and fellow officers can recite any number of stories about the drug's ever-increasing impact.
Gov. Dan Malloy could create a legacy with a vibrant new park system in eastern Connecticut.
Some research points to a connection between the Pequot massacre in Mystic and Thanksgiving.
Dancing steps in support of Higher Edge college program fundraiser
Joey 'Jaws' Chestnut gobbles 9.35 lbs of turkey to win Foxwoods competition
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May 7 (Bloomberg) -- Sisters Katherine Kallinis Berman and Sophie Kallinis LaMontagne, the co-founders of Georgetown Cupcake, discuss the designer cupcake craze and their TLC TV show "DC Cupcakes." They speak with Pimm Fox on Bloomberg Television's "Taking Stock." (Source: Bloomberg)
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Wii U
So I just bricked my Wii U on the new firmware update.
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download froze during downloading. left it on for 6hrs without any activity. pulled the plug and.... BRICK!!
well done nintendo. I thought it was only the launch firmware update that had this problem? I had the firmware installed. I was downloading the new 2.1.0 december update. Any fix I can do or is it 100% bricked and needs repairs?
If its the 2nd option than looks like I'll be $270 richer tomorrow.
how can they design a system that bricks on the downloading part!? It wasnt even installing! Even if it was on the installing part (which is was not) it should be a slim chance on bricking (like every other device ever created).
wow. I cant even get my RENTED game out of the system now. white light is on indicating the game is in system. press eject and wont come out.
any manual eject on this thing (paperclip) like regular dvd drives?
Are you able to turn it on and is there a black screen? If so, leave it on. It might still be able to finish downloading if you wait it out.
If not, try this:
-Try unplugging it and then waiting 2 minutes. Might reset it.
-Hold down the power button for 6 seconds.
Now Playing: videos games
Stop acting like it's all Nintendo's fault. Any game system that gets firmware updates could possibly do this. Even on PS3 there's a warning not to turn off the system. After six hours is a little bit rediculous. Your internet must really suck if it's taking that long.
sounds like his download froze.. not his fault
may have timed out.... again not his fault
installing firmware WHILE it is downloading IS nintendos fault.
others download the whole file before it installs. why nintendo didnt follow this is beyond me.
i have a friend whos bricked launch day. took it back got a new one. wich he bricked intentionally. got a new one, wash rinse repeat. 6 later he got his money back and nintendo ate the cost of 6 wii u's.
this explains the sales
PSN- WartPigX
Karma is just fun money
Does the red light comes on when you plug it in or is it totally dead? It might be the AC power adapter. When that happens with the Wii. You'd had to unplug the AC from both the console and the wall socket and then wait 2 minutes before plugging it back in. That sometimes worked. It's called resetting the AC power adapter.
It's worth a try though.
Oh and you must unplug everything from the Wii U too.
[This message was deleted at the request of the original poster]
Wii U=next gen 360
durability lolz
my grammar sucks and i dont care
disappointing game of the year = re6 (6.5/10)
wartpigX posted...
sounds like his download froze.. not his fault
Your friend is a disturbed individual. Why would he waste time bricking six system?
Now Playing: videos games


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New Edward Cullen Charm <3
after biology :]
black pants, grey sweater, cullen crest cufflink, black notebook, bushy eyebrows, golden eyes and bronze hair :]
i am still having some problems with the back of the hair, so if you have any suggestions, i'd really appreciate them :] <3
in one picture you can see his volvo c30 and in two of them you can see my other characters
i still need to work out a size, cause all of them turn out different, but hey, this is only my 6th :]
Eszti posted this project as a creation without steps
Here are some similar tutorials to help you make this one!
Cupcake girl · , , United States · 28 projects
Andrea B. · Budapest, Budapest, Hungary · 21 projects
Love the silver Volvo:)


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18 results for "game"
Upset win is lasting ACC memory for TerpsHeather Dinich
COLLEGE PARK, Md. -- On the third floor of Maryland's Comcast Center, a line of about 500 people wrapped around the concourse Sunday morning, fans clutching their game programs and other memorabilia, patiently waiting for autographs from former coach...Blog | March 09, 2014
Final: Georgetown 89, Duke 77Heather Dinich
WASHINGTON -- Georgetown played a complete game, and even the President of the United States was here to witness it. The question is how far the Hoyas can ride this momentum. Duke, on the other hand, dropped to 1-4 on the road -- not exactly the resu...Blog | January 30, 2010
Georgetown in controlHeather Dinich
WASHINGTON -- At this point, it's the Hoyas' game to lose. Georgetown is leading 78-58, working their way inside, making their layups, waving their arms and the Verizon Center crowd is deafening. Duke, on the other hand, can't even make its free t...Blog | January 30, 2010
Georgetown Hoyas all smiles after convincing win over Duke Blue D...Heather Dinich
Georgetown's loss to Duke last season started a five-game losing streak in which the Hoyas' season spiraled out of control. After a convincing win over the Blue Devils, they showed another late collapse isn't likely this season.Story | Conversation | January 30, 2010
NCAA tournament: After two-year lull, Duke meets expectationsHeather Dinich
With expectations always so high for Duke, it was a long two years between Sweet 16 appearances for the Blue Devils.Story | Conversation | March 21, 2009
NCAA Tournament: Ty Lawson makes the differenceHeather Dinich
GREENSBORO, N.C. -- Yes, Ty Lawson does make a difference, and he proved it in the second half of North Carolina's 84-70 win over LSU. It was an exciting, back-and-forth game until late in the second half, when the Tar Heels used a 16-2 run to go a...Blog | Conversation | March 21, 2009
NCAA Tournament: LSU plans to outpace UNCHeather Dinich
GREENSBORO, N.C. -- LSU's game plan for keeping pace with North Carolina is simple: "We're going to run like hell," coach Trent Johnson said, smiling. The Tigers will also try to copycat what Boston College did in the Eagles' 85-78 win over UNC on ...Blog | Conversation | March 20, 2009
North Carolina Tar Heels' Ty Lawson pinning hopes practiceHeather Dinich
Ty Lawson's availability for the Tar Heels' second-round game Saturday against LSU depends on how he practices Friday afternoon, the point guard said.Story | Conversation | March 20, 2009
NCAA tournament: North Carolina's Ty Lawson likely to miss first ...Heather Dinich
North Carolina coach Roy Williams said Wednesday there is a "huge, huge probability Ty Lawson will not play" in Thursday's NCAA tournament first-round game against Radford because of an injury to Lawson's right big toe.Story | Conversation | March 18, 2009
NC State matriarch continues to fight the most important battleHeather Dinich
Kay Yow has won and lost many games while at NC State. But the battle she continues to fight, and win, is the most important, and it is an integral piece of the Wolfpack's history, writes Heather Dinich.Story | Conversation | April 01, 2008
Quentin Thomas just needed the confidence to excelHeather Dinich
Quentin Thomas was largely an afterthought at UNC, until the Tar Heels lost their top two point guards. Then he was thrust into duty, and his growing confidence has now given UNC two dependable point guards, writes Heather Dinich.Story | Conversation | March 24, 2008
Curry, Richards pay dividends in Davidson's Sweet 16 runHeather Dinich
In taking down mid-major poster boy Gonzaga and Big East giant Georgetown, Davidson showed its 24-game winning streak is no fluke, writes Heather Dinich.Story | Conversation | March 23, 2008
Tobacco Road paves way for North Carolina's championship bidHeather Dinich
North Carolina's win over Clemson in the ACC championship solidified the Tar Heels' No. 1 overall seed in the NCAA tournament. It also paved the way to the championship game -- as long as UNC stays on Tobacco Road.Story | Conversation | March 16, 2008
Clemson crashes Carolina party; Greenberg lobbies for a bidHeather Dinich
Virginia Tech came close but couldn't stop Tyler Hansbrough and North Carolina. But Clemson knocked off Duke to crash the Tobacco Road party that is typically the ACC final, writes Heather Dinich.Story | Conversation | March 15, 2008
Miller defends Burrell's defense of XavierHeather Dinich
Stanley Burrell bashed the Atlantic 10 for omitting a Musketeer from the all-conference first team. But if Xavier keeps on winning in the A-10 tourney, its game will do enough talking.Story | Conversation | March 13, 2008
Instant Analysis: Clemson-MarylandHeather Dinich
Here is Heather Dinich's instant analysis of Clemson's 73-70 win over Maryland.Story | Conversation | March 02, 2008


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Medical College of Wisconsin to Sponsor Midwestern Conference for Surgical Pathology
By The Medical College of Wisconsin
September 12th – 14th, 2014
The Medical College Department of Pathology will sponsor "The Midwestern Conference: Update Course in Surgical Pathology" September 12th – 14th in Milwaukee. The annual conference, now in its seventh year, will bring to Milwaukee an estimated 100 practicing surgical pathologists, oncologists, and other health care professionals from across the country.
Saul Suster, M.D., professor and chairman of pathology at the Medical College, is the course director. Invited speakers include pathologists representing numerous sub-specialties from the Medical College, as well as guest lecturers from Beth Israel Deaconess Medical Center, Harvard Medical School, Mayo Clinic, Bostwick Laboratories, United States and Canadian Academy of Pathology (USCAP) and Massachusetts General Hospital.
"Surgical pathology is an evolving field of medicine, and this conference brings together top practitioners in the field to share advances in technology and terminology, learn about new techniques of diagnosis, and evaluate current criteria of diagnosis, so that we are providing patients the most accurate, timely care," said Dr. Suster.
The conference will be held at the Intercontinental Hotel downtown Milwaukee.
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Dr. Askew urges urge men, particularly African-American men and other men of color, to know their heart health status.
Learn more about the evaluation of promising career pathways programs.
Let's Move! Child Care is a voluntary initiative to empower early care and education to instill healthy choices from the start.
Two recent publications highlight early implementation and outcomes of the Tribal Health Profession Opportunity Grants program.
April 26 is the National Take-Back Initiative - turn in your unwanted prescription medications for safe and proper disposal.
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Eggs: Where sound nutrition and egg safety intersect
Editor's note: This is a guest post by By Debbie Rayhab, MBA, Director Healthcare Marketing Safest Choice™ Pasteurized Eggs
Approaches to nutrition counseling today are continually expanding to embody a holistic approach. Wellness is a lifestyle choice that includes nutrition and many other healthy choices. This means food safety as well. The USDA/HHS Dietary Guidelines for Americans 2010 note, "A healthy eating pattern also embodies food safety principles to avoid foodborne illness."
Food safety can be an important part of everyone's health routine. Every year, 1 in 6 Americans gets a foodborne illness, according to CDC estimates. Avoiding foodborne illness can be challenging, especially at certain stages of life.
CDC data relates that pregnant women and individuals in the golden years of life are particularly vulnerable to foodborne illness. The same is true for small children. In fact, 1 in 5 Americans is at heightened risk for foodborne illness, according to 2011 research.
The FDA and the CDC are increasingly focusing on egg safety in particular. This is because eggs, while nutritious (containing protein, vitamins A, D, E, iron, choline, lutein and zeaxanthin), represent a high- risk food. The quick facts:
Among foodborne pathogens, Salmonella causes the most illnesses—more than 1 million per year, according to the […]
New CMS rule gives dietitians order-writing privileges
Starting July 11, 2014, Registered Dietitian Nutritionists will be able to order diets in hospitals under Centers for Medicare and Medicaid Services (CMS) regulation. According to CMS, "the addition […]
Our spring magazine and Medicare-compliant obesity counseling
I hope you all had a chance to see the Spring issue of the Nutrition Dimension magazine (either via the mail or the digital version) which is devoted to […]
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RDs and DTRs: Feeling overwhelmed with so many nutrition CE choices? It's hard to make a decision when there are over 250 courses to choose from. Narrow your search […]
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Artist: Finian's Rainbow
Album: Miscellaneous
Genre: Jazz
What is the curse that makes
The universe so all bewilderin'
What is the hoax that just provokes
The folks they call God's children
What is the jinx that gives a body and his brother
And everyone around the run-around
Necessity, necessity
A most unnecessary thing, necessity
What throws the monkey wrench in
A fella's good intention
That nasty old invention, necessity
My feet want to dance in the sun
My head wants to rest in the shade
The Lord says go out and have fun
But the landlord says, "Your rent ain't paid"
Necessity, it's plain to see
What a lovely old world
This silly old world can be
But no, it's all in a mess, account of necessity
I'd like to play some tennis or take a trip to Venice
But sister, here's the menace, necessity
Oh, satan's the father of sin and Cupid's the father of love
Oh, hell is the father of gin
But no one know's the father of necessity, necessity
That's the maximum that a minimum thing can be
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text: This was one of the options for breakfast offered by Beach Bungalow Inn and Suites. We enjoyed the food very much. There were both Mexican food breakfasts and traditional American breakfast options available. We appreciated the nice quiet atmosphere, and that it seemed very clean. We had originally tried a very crowded breakfast place close to the water the day... More


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George Kottaras Rumors
Blue Jays Outright George Kottaras
The Blue Jays announced that they have outrighted catcher George Kottaras off the 40-man roster and officially announced the outrights of Munenori Kawasaki and Dan Johnson, both of which were made known earlier in the week.
Kottaras, 31, batted a strong .233/.351/.533 with three homers in 38 plate appearances between the Indians, Cardinals and Blue Jays this season. Two of those homers came as a member of the Indians in his first game of the season.
The journeyman catcher has always shown plus plate discipline and plus power but low batting averages, as evidenced by his .215/.326/.411 career batting line. Kottaras has struck out in 23.7 percent of his career plate appearances, but that number has jumped to 35.3 percent over the past two seasons (164 PA). Defensively speaking, he's thrown out just 18 percent of opposing base-stealers in his career, and pitch-framing metrics haven't been kind to him.
Kottaras and Johnson have both elected free agency, per the Blue Jays, while Kawasaki has yet to do so. Brendan Kennedy of the Toronto Star tweets that Kawasaki will likely do the same thing that he did last offseason: seek a Major League deal elsewhere but return to the Blue Jays as a minor league free agent if he is unable to find one.
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Full Story | Comments | Categories: Dan Johnson | George Kottaras | Munenori Kawasaki | Toronto Blue Jays | Transactions
Minor Moves: Anna, Kottaras, Jackson
We'll track today's minor moves here.
- The Pirates have outrighted infielder Dean Anna to Triple-A Indianapolis, according to the International League transactions page. Since being claimed by the Bucs in early July, the 27-year-old Anna has batted just .186/.368/.302 in 57 plate appearances. Overall, he has just a .601 OPS at the Triple-A level this season, and he didn't fare any better in the bigs with New York, posting a .518 OPS in 25 plate appearances. Anna excelled with a .331/.410/.482 batting line with the Padres' Triple-A affiliate in 2013, however, indicating that there's some upside in his bat.
- The Blue Jays have signed catcher George Kottaras and sent him to Triple-A Buffalo, Shi Davidi of Sportsnet.ca reports. The Cardinals released Kottaras last month after they acquired A.J. Pierzynski. He's a lifetime .216/.326/.414 hitter in parts of seven seasons with the Red Sox, Brewers, Athletics, Royals, Indians and Cardinals.
- The Brewers have acquired pitcher Jay Jackson from the Pirates for cash considerations, Tom Haudricourt of the Journal Sentinel tweets. Jackson, 26, has posted a 4.89 ERA in 84 2/3 innings as a swingman with Triple-A Indianapolis, but with 9.2 K/9 and 3.8 BB/9. He has also pitched in the Cubs and Marlins systems. He's recently won praise for his stuff, with Pirates Triple-A catcher Tony Sanchez suggesting Jackson has the potential to be a good big-league reliever.
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Full Story | Comments | Categories: Dean Anna | George Kottaras | Milwaukee Brewers | Pittsburgh Pirates | Toronto Blue Jays | Transactions
Minor Moves: Joe Saunders, George Kottaras, Matt Guerrier
Here are the day's minor moves:
- Lefty Joe Saunders has been released, the Royals announced on Twitter. Saunders opted out of his minor league deal, reports Chris Cotillo of MLBDailyDish.com (Twitter link). The 33-year-old lefty will presumably now look for his fourth organization of the year.
- The Cardinals have released catcher George Kottaras after designating him for assignment to create room for the addition of A.J. Pierzynski, reports Jenifer Langosch of MLB.com (via Twitter). Kottaras, 31, saw just six plate appearances for the Cardinals but owns a .269/.375/.615 slash on the year through just 33 plate appearances.
- Twins reliever Matt Guerrier has cleared waivers and been outrighted to Triple-A, but will elect free agency rather than accepting the assignment, tweets Chris Cotillo of MLBDailyDish.com. Guerrier could hold appeal to contenders as a depth piece, particularly on a minor league deal. The veteran righty has produced a solid 3.86 ERA in 28 innings, but has struck out just 3.9 batters per nine.
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Full Story | Comments | Categories: George Kottaras | Joe Saunders | Matt Guerrier | Minnesota Twins | St. Louis Cardinals | Transactions
Cardinals Designate George Kottaras For Assignment
The Cardinals have designated catcher George Kottaras for assignment, Derrick Goold of the St. Louis Post-Dispatch writes. The move clears space for new catcher A.J. Pierzynski.
Kottaras collected only six plate appearances for the Cardinals, who claimed him from the Indians July 11. For the season, Kottaras only has 33 plate appearances, hitting three homers in that span. He's hit .216/.326/.414 in parts of seven seasons in the big leagues.
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Full Story | Comments | Categories: George Kottaras | Newsstand | St. Louis Cardinals
Cardinals Claim George Kottaras
The Cardinals have claimed catcher George Kottaras off waivers from the Indians, reports Jon Heyman of CBS Sports (on Twitter). Kottaras was recently designated for assignment by Cleveland.
It's not surprising to see St. Louis pursuing catching depth after yesterday's news that Yadier Molina will miss the next eight to 12 weeks in order to have a torn ligament in his thumb surgically repaired. The 31-year-old Kottaras has long been known to have an excellent eye at the plate and some power. The career .216/.326/.415 hitter has 14 percent walk rate in 847 Major League plate appearances, and his .199 isolated power mark (slugging minus batting average) is well above-average for any hitter, let alone a catcher.
This, of course, doesn't preclude the Cardinals from pursuing further upgrades behind the dish as the summer wears on. For the time being, however, he should be able to provide a solid OBP if the Redbirds prefer him to one of Tony Cruz or Audry Perez, neither of whom offers much with the bat.
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Full Story | Comments | Categories: Cleveland Indians | George Kottaras | Newsstand | St. Louis Cardinals | Transactions
Indians Acquire Chris Dickerson, Designate George Kottaras
The Indians announced that they have acquired outfielder Chris Dickerson from the Pirates in exchange for a player to be named later or cash considerations. Dickerson's contract will be selected for tonight's game, and George Kottaras has been designated for assignment to create roster space.
The 32-year-old Dickerson has a spotty Major League track record, but he was having an excellent season for Triple-A Indianapolis in the Pirates organization. In 280 plate appearances, Dickerson batted .309/.407/.479 with seven homers and 12 steals.
Dickerson grades out as an excellent defender at all three outfield spots, per Ultimate Zone Rating and Defensive Runs Saved — an attribute that likely appealed to Cleveland with Michael Bourn on the shelf for the next three to four weeks due to a hamstring strain. That glove has come along with a questionable bat for much of his career, however, as he's batted just .233/.275/.361 over his past four stints in the Majors — a span of 287 plate appearances. Dickerson did have a strong start to his big league career with the Reds, however, hitting .283/.383/.440 through his first 421 PA in 2008-09.
The 31-year-old Kottaras has a strong .286/.385/.714 batting line for the Indians this season, though it's come in a sample of just 27 PA. Nearly all of his production came in his first game with Cleveland, when he went 2-for-3 with a pair of homers. Nonetheless, Kottaras has long been known to have an excellent eye at the plate and some power. The career .216/.326/.415 hitter has 14 percent walk rate in 847 Major League plate appearances, and his .199 isolated power mark (slugging minus batting average) is well above-average for any hitter, let alone a catcher.
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Minor Moves: Kottaras, Getz, Greene
Here are the day's minor moves:
- Indians catcher George Kottaras has accepted his assignment to Triple-A, the club announced. He had the right to elect free agency, but will instead stay with the Cleveland organization.
- Second baseman Chris Getz has cleared waivers and been outrighted to Triple-A, according to a tweet from the Blue Jays' top affiliate announcing his activation (hat tip to MLB.com's Gregor Chisholm). The 30-year-old has played in over 450 MLB games in parts of seven seasons, but saw action in just ten contests this year for Toronto before being cleared from the 40-man. Getz will pick back up in the upper minors with a .309/.382/.338 triple-slash (with 6 stolen bases) through 76 plate appearances.
- The Braves have signed outfielder Justin Greene to a minor league deal, according to the MLB transactions page. Greene, a 28-year-old career farmhand, reached the Triple-A level with the White Sox organization in 2011 and 2012, but managed only a .244/.310/.395 line in 301 plate appearances there. Greene had a solid season for the Diamondbacks' Double-A affiliate last year (.308/.377/.413 with 31 stolen bases), but was off to a rough .174/.245/.239 start in his first 102 trips to the plate in 2014.
- As reflected in MLBTR's DFA Tracker, Carlos Marmol (Marlins) is the only player currently in DFA limbo. George Kottaras (Indians) is still deciding whether or not to accept his outright assignment.
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Full Story | Comments | Categories: Atlanta Braves | Chris Getz | Cleveland Indians | George Kottaras | Toronto Blue Jays | Transactions
Minor Moves: Hector Ambriz Accepts Outright
Here are Sunday's minor moves from around MLB:
- The Reds have released pitcher Nick Schmidt, tweets Chris Cotillo of MLB Daily Dish. The 28-year-old lefty pitched 14 1/3 innings for Triple-A Louisville, posting a 7.53 ERA with 11 strikeouts and ten walks. He had previously pitched in the Padres and Rockies systems.
- The Indians have released pitcher Brett Brach, who had been at Triple-A Columbus, Cotillo tweets. Brach, the brother of Orioles pitcher Brad Brach, was a 10th-round pick in 2009. He spent most of the 2013 season with Double-A Akron.
- Cotillo also notes that the Mariners have released pitcher Jonathan Arias, who had made eight relief appearances for Triple-A Tacoma. He had a 9.82 ERA there, striking out ten batters and walking seven in 14 2/3 innings. Arias, 26, had posted very good strikeout numbers at several previous minor-league stops, however.
- Right-hander Hector Ambriz has accepted his outright assignment to Triple-A by the Padres, tweets MLBDailyDish.com's Chris Cotillo. Ambriz, who was designated for assignment Thursday, could have refused the assignment and elected free agency.
- Infielder Josh Wilson has cleared waivers, tweets Jeff Wilson of the Fort Worth Star-Telegram. Wilson, who was designated for assignment by the Rangers Thursday, now has 72 hours to accept an outright assignment or elect free agency.
- Catcher George Kottaras has cleared waivers, tweets CBSSports.com's Jon Heyman. Kottaras was designated for assignment by the Indians Tuesday and now has 72 hours to accept an outright assignment or elect free agency. The 30-year-old saw only four plate appearances during his brief stint with the Indians, but he was productive smashing a pair of solo home runs and drawing one walk.
- There are four players currently in DFA limbo, per MLBTR's DFA Tracker: Buddy Boshers (Angels), Maikel Cleto, (White Sox), Carlos Marmol (Marlins), and Chris Getz (Blue Jays).
Charlie Wilmoth contributed to this post.
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Full Story | Comments | Categories: Cincinnati Reds | Cleveland Indians | George Kottaras | Hector Ambriz | Josh Wilson | San Diego Padres | Seattle Mariners | Texas Rangers | Transactions
Indians Designate George Kottaras For Assignment
The Indians have designated catcher George Kottaras for assignment, tweets MLB.com's Jordan Bastian. With the move, an active roster space was cleared for reliever Josh Tomlin.
The 30-year-old Kottaras saw only four plate appearances during his brief stint with the Tribe, though he delivered two home runs and drew a walk in that time. Kottaras caught on in Cleveland with a minor league deal after being released by the Cubs late in the spring. (He had been picked up by Chicago from the Royals via trade, but lost the backup battle.) Kottaras has drawn attention in the past for his ability to get on base (.355 OBP since 2012), and could appeal to some other clubs around the league.
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Quick Hits: Hoyer, Morrow, Hawkins, Angels
A strong young pitching arm has long been the most valuable commodity in baseball, but as ESPN's Buster Olney writes in his latest Insider-only column, some executives are beginning to put a greater premium on young hitters. Position players may rate higher due to defensive value, not to mention that big bats are becoming a rarer commodity as scoring declines around the game.
Here are some news and notes from around the baseball world…
- The Cubs are widely expected to be sellers at the trade deadline but GM Jed Hoyer told reporters (including CSN Chicago's Patrick Mooney) that trade talks are currently "non-existent" and things won't get serious for at least a few more weeks. "I certainly talk to a lot of GMs on a daily or weekly basis," Hoyer said. "But having a GM call about a specific player? I'm not even sure I fielded one of those yet. Really, that trade talk always dies right at the end of spring training."
- The Blue Jays have shifted Brandon Morrow to the 60-day disabled list, the team announced to reporters, including MLB.com's Gregor Chisholm (Twitter links). The right index finger injury that put Morrow on the 15-day DL earlier today was revealed to be a torn tendon sheath, and if the injury isn't healed by July, Morrow will have to undergo season-ending surgery. This looks to be the third time in as many years that Morrow has suffered an injury that cost him at least two months of the season.
- LaTroy Hawkins' presence could've greatly helped solve the Mets' bullpen issues, which is why Andy Martino of the New York Daily News opines that the team isn't serious about contending. Hawkins signed a one-year, $2.5MM deal with the Rockies, a modest contact that Martino feels the Mets should've and could've easily topped in order to shore up their bullpen's questionable depth.
- The Angels' struggling bullpen could get a boost from the farm system very soon, Mike DiGiovanna of the Los Angeles Times writes. GM Jerry Dipoto said that Double-A right-handers R.J. Alvarez and Cam Bedrosian could both be "a phone call away. They're doing it against high-level professional hitters. I feel like both can help sooner rather than later."
- Indians catcher George Kottaras is likely to be designated for assignment once Yan Gomes returns from the paternity list, Paul Hoynes of the Cleveland Plain Dealer reports. Kottaras was just called up today by the Tribe to take Gomes' place, but he is out of options. The 30-year-old catcher signed a minor league deal with the Tribe in late March.
- In an Insider-only piece for ESPN.com, Mike Petriello identifies three early weaknesses plaguing the Cardinals, Dodgers and Tigers in 2014.
- Ten well-known names ranging from Major League veterans to retired NBA star Tracy McGrady are active in the independent leagues, Zachary Levine writes for FOXSports.com in a brief review of these ten players' career situations.
- Giving minor league starting prospects Major League experience as relievers and eventually working them into the rotation is a strategy popularized by Earl Weaver's Orioles in the 1970's, and this idea has been one of the cornerstones of the Cardinals' success over the last decade, Peter Gammons writes in his latest column for GammonsDaily.com.
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The Digital Life with Kevin Lockett Podcast
Welcome to DigitalKev.com, where some tech lovin' dude from Akron,Ohio named Kevin Lockett who talks to fascinating people across the country about social media, pop culture and life. Reach out to me at email@example.com Twitter.com/KevinLockett, KevinLockett.com or @KevinLockett on Instagram. Check out Soul88.com for the best in entertainment. and like the podcast Facebook.com/DigitalKev.
|Recent Episodes
|Scott O'Brien: Kickstarter & Cleveland Sports Coloring Books
|November 24, 2014
|On this episode, Kevin Lockett talks to Scott O'Brien, who used his love for Cleveland sports and Kickstarter to create succesful coloring books: "Why is Daddy Sad on Sunday" and "Why is Daddy Happy on Sunday". Even if you are not a fan of Cleveland sports, the way Scott used crowdsourcing to fund his coloring books is a must listen. Learn more about Scott at Clecoloringbook.com and take a look at his first Kickstarter campaign here at https://www.kickstarter.com/projects/1254956201/disappointing-moments-in-cleveland-sports-coloring
|James Lopez: The Phat Startup & The Tech 808 Conference
|November 17, 2014
|On this episode, Kevin Lockett talks to The Phat Startup co-founder James Lopez on their upcoming Tech 808 conference in New York City.Tech 808 technology conference, how the Lean Startup method has a lot in common Hip Hop, diversity in technology, Tech 808's first keynote speaker, Girls Who Code founder, Resha Sauja and the origin of the term #BOSSUP. Learn more about the conference at Tech808.co and ThePhatStartUp.com Follow Kevin at @KevinLockett on Twitter & Instagram, listen to past shows at DigitalKev.com and email firstname.lastname@example.com for guest information and sponsorship oppounities.
|Chase R. McCurdy: Tips From a Passionate Photographer
|November 12, 2014
|On today's episode, Kevin Lockett talks to L.A. photographer Chase McCrurdy on his love for photography and tips for newbie photogs. Follow Chase at Chasermccurdy.com, chasermccurdy.tumblr.com, facebook.com/chasermccurdy, twitter.com/chasermccurdy and instagram.com/chasermccurdy. Listen to past shows at DigitalKev.com and follow Kevin at Twitter.com/KevinLockett and Instagram.com/KevinLockett
|Byron Hurt: Documentaries and Filmmaking Tips
|November 4, 2014
|On today's episode, Kevin Lockett talks to renowned director Byron Hurt on documentaries and filmmaking tips.learn more about Byron at BHurt.com. Listen to past shows at DigitalKev.com and follow Kevin @KevinLockett on Twitter and Instagram.
|Maurice Cherry: Diversity in Tech w/ Revision Path
|August 12, 2014
|On this episode, Kevin Lockett talks to Maurice Cherry about his Revision Path podcast. During their discussion, Maurice talks about , creating his company 3eighteen Media, launching the Black Weblog Awards , hear the criticism he had to deal with promoting African Americans in technology and how Dwayne Wayne from a Different World played a part in his tech career. Make sure to check out Maurice at revisionpath.com and 3eighteenmedia.com. Follow Kevin @KevinLockett on Twitter as well as Soul88.com, DigitalKev.com and KevinLockett.com


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It was a good read.
Submitted by RonPaulWins on Fri, 02/07/2014 - 01:40. Permalink
If Glenn has info on US state sponsored terrorism, from the Edward trove, I sure hope that he releases at least some of it. Other than the already known US drone program that IS terrorism and also technically state sponsored.
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Market Square,
T 01772 258248 (office 10am-4pm)
T 01772 905414 (event bookings)
Harris Museum
Opening hours:
Mon 11am - 5pm
Tues – Sat 10am - 5pm
Closed Sundays & Bank Holidays
FREE entry
Wed 26th, from 1pm
Fine Art gallery will be partially closed. 70 Years of Pauline display will be open as normal. All galleries will close at 4.45pm. Apologies for any inconvenience caused.
Sat 29th, 1.30-3.30pm
Scent Bottle Treasure Hunt
Ages 5-12
Tues 2nd, 11am-12pm
Little Hands On
Under 5s & carers
Fri 5th, 10.30-11am
Little Hands On Story Time
Under 5s & carers
Sat 6th, 1.30-3.30pm
Hands On at the Harris
Ages 5-12
Click on the titles for more details or click here for more events


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Hollywood Celebs Leighton, Pribram to Take Plunge for "Loveswell" Gala Benefitting Heal the Bay.Heal the Bay Heal the Bay is a U.S. environmental advocacy non-profit organization based in Santa Monica, California.
Heal the Bay is dedicated to protecting California's Santa Monica Bay, a region of the Pacific coast encompassed by Malibu's Point Dume on the north and the Palos Verdes
HOLLYWOOD -- Actress/model Alexandra Leighton and pro surfer/"ecowarrior" James Pribram will host a gala reception for Loveswell benefitting Heal the Bay on May 1(st) at the Hudson Guild Hudson Guild is a multi-service, multi-generational, community-based organization rooted in and primarily focused on the Chelsea neighborhood of Manhattan, New York. It was founded in 1895. Theatre in Hollywood.
Leighton and Pribram will serve as celebrity hosts following the Hollywood premiere of Loveswell, a one-man show that dives deep into the ebbs and flows of a relationship as seen through the eyes of actor/writer/avid surfer John Fortson.
Net proceeds Net Proceeds
The amount received after all costs are deducted from the sale of a piece of property or security.
In the case of an investor selling a security, net proceeds represent the proceeds from the sale minus any trading costs (i.e. commissions). raised will go directly to Heal the Bay, a non-profit group that fights for workable solutions to the problems threatening Southern California's coastal waters.
Fortson began supporting Heal the Bay after a visit from his nephew, who wanted to learn to surf. "There were large signs posted on the beach warning "Contaminated contaminated,
v 1. made radioactive by the addition of small quantities of radioactive material.
2. made contaminated by adding infective or radiographic materials.
3. an infective surface or object. Water: No Swimming," Fortson said. "He couldn't believe what we Californians know: that after any rain, the water becomes polluted and can make you sick. We have to find a solution to make our waters safe for all who enjoy them."
Only 35 tickets will be sold for Loveswell's VIP reception. Guests will be treated to an array of Italian regional delights,courtesy of Terroni, LA's hottest restaurant. The reception will also feature great wines and prosecco, a raffle, giveaways, and a showing by famed surf artist Meegan Feori, who designed the Loveswell set.
Alexandra Leighton began her career as commercial print and runway model in New York New York, state, United States
New York, Middle Atlantic state of the United States. It is bordered by Vermont, Massachusetts, Connecticut, and the Atlantic Ocean (E), New Jersey and Pennsylvania (S), Lakes Erie and Ontario and the Canadian province of . She landed a recurring role in CBS's "Swingtown," playing the fun-loving, upper class swinger, Cherie Hyatt. Alexandra has appeared on "The Hills" and in numerous commercials. She is an active philanthropist who works tirelessly to raise funds for diabetes, cancer, multiple sclerosis and other charities. She is the voice of the American Heart Association American Heart Association (AHA),
n.pr a national voluntary health agency that has the goal of increasing public and medical awareness of cardiovascular diseases and stroke, and thereby reducing the number of associated deaths and disabilities. , and continues to work as a spokesmodel and actress, giving back to her community and incorporating green living into her daily life.
James Pribram is a professional surfer, writer, commentator and environmental leader. His writings have appeared in the LA Times, Surfer's Path, Surfer Magazine, Surfing, Water, and publications worldwide. He has been an environmental leader in his community, as co-founder of an non-profit organization A non-profit organization (abbreviated "NPO", also "non-profit" or "not-for-profit") is a legally constituted organization whose primary objective is to support or to actively engage in activities of public or private interest without any commercial or monetary profit purposes. for people with ocean-related spinal injuries. James has served on the Laguna Beach Laguna Beach (ləg`nə), city (1990 pop. 23,170), Orange co., S Calif., on the Pacific coast; founded 1887, inc. 1927. Water Quality and Environmental Committees and as board member for the Clean Water Now! Coalition. He received the 2007 John Kelly Environmental Achievement Award.
Loveswell runs Friday through Sunday, May 1st-June 7(th), at the Hudson Guild Theatre, 6539 Santa Monica Blvd. in Hollywood. Tickets are available at www.plays411.net. For complete information on Loveswell and the screenplay, visit www.loveswell.com.
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Ms. Leeann Dunnington
Allergy & Immunology, Lee Physicians Group Of Allergy
- 4761 S Cleveland Ave Ste 3
Fort Myers, FL 33907
- 1 Office Location
- (239) 343-9722
Ms. Leeann Dunnington is a practicing physician. Ms. Dunnington practices medicine in Fort Myers, FL and specializes in Allergy & Immunology. Ms. Dunnington is affiliated with Lee Memorial Health Systems. Ms. Dunnington speaks English and Spanish.
Gender: Not Available
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Languages Spoken: English, Spanish
Medical School: Not Available
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Hospital Affiliations: Lee Memorial Health Systems
Specialties: Allergy & Immunology


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free shippingon most orders over $49*
Get 3% Backwith AllModern rewards
Safavieh Shawmont 4 Piece Deep Seating Group with Cushions
The Shawmont outdoor set brings a resort-like ambiance outdoor living to any home. The chairs feature weather resist removable beige cushion and comfortable stylish arm rests. Weather, mildew, and insect resistant, this 4-piece patio set is ideal for casual outdoor dining.
Safavieh Shawmont 4 Piece Deep Seating Group with Cushions
Weights & Dimensions
|Frame Material: Aluminum
|Woven: Yes
|Frame Finish: 2: Brown
|Frame Finish: 3: Grey
|Cushions Included: Yes
|Seating Design: Deep seating
|Seating Capacity: 4
|Style: Contemporary
|Country of Manufacture: Imported
"Hi, does this seating group require assembly?" asked by Ann
Still have questions about this product? We're here to help
Safavieh Shawmont 4 Piece Deep Seating Group with Cushions
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Tell us what you think about the Shawmont 4 Piece Deep Seating Group with Cushions. It will help us provide you with better products in the future and help your fellow Wayfair shoppers make better purchases.Write A Review
Small spacesmall pieces
Laurie from Austin, TX– Verified Buyer
Great for small space, cushions are thin, furniture is small. If you are above average build, you may find the chairs a bit tight.
Perfect Summertime Patio Set
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Style, comfort, and easy assembly make this four piece conversation set a true bang for your buck. As stated in prior reviews, be sure to pay mind to the provided dimensions, as this is not huge in scale; however, it worked perfectly for us and our space. It's quite lightweight, but withstood the summertime elements perfectly. The cushions dried quickly when they were rained on, and the set looks exactly as it did the day it was delivered (no fading, rusting, or damage whatsoever).
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I love the color of this patio set, I purchased it for a friend and it looks wonderful in their small patio area. They said the assembly was fairly easy it was great for a party they had. Please note this patio set is very low to the ground, so it looks small but comfortable for adults to sit on. I would recommend this product especially since I got it on sale for my friend.
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Great set for the price!
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Easy assembly. Fits nicely in our small patio space. Seems like it is made of quality materials.
deck or outdoor furniture
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great product for our deck. Lightweight and handsome. A bit thin so we worry about it holding up, but so far it has been very good.
Needs pillows
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Ames seating .loved it.
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I have a small patio and the set fit perfectly. I put it together myself quite proud of that.although it take me most of the day. The sale was great. I don't think I could have done better..
About the ManufacturerSafavieh is a leading manufacturer and importer of fine rugs. Established in 1914 in the capital of Persian weaving masters, three generations of knowledge and experience are behind Safavieh's award winning collections.
OUR SKU # FV34081Shawmont 4 Piece Deep Seating Group with Cushions is also sometimes listed under the following manufacturer numbers: FOX6010A, FOX6010B


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Crying semen. After one takes a money shot in the nose (see dick knipfing, the semen comes out of the tear ducts as pearl rain.
Only Prince is man enough to cry pearl rain
by cuntchocula August 28, 2007
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Matthew P Scott
Stanford Medicine, Stanford, California, United States
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Claim your profile
Total impact
Available from: PubMed Central
Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila.
Jian Cao
Julie Ni
Wenxiu Ma
Vanessa Shiu
Luis A Milla
Sangbin Park
Maria L Spletter
Sheng Tang
Jun Zhang
Xing Wei
Seung K Kim
, Matthew P Scott
[Show abstract]
[Hide abstract]
Insulin-producing cells (IPCs) in the Drosophila brain produce and release insulin-like peptides (ILPs) to hemolymph. ILPs are crucial for growth and regulation of metabolic activity in flies, functions analogous to those of mammalian insulin and insulin-like growth factors (IGFs). To identify components functioning in IPCs to control ILP production, we employed genomic and candidate gene approaches. We used laser microdissection and mRNA sequencing to characterize the transcriptome of larval IPCs. IPCs highly express many genes homologous to genes active in insulin-producing beta cells of the mammalian pancreas. The genes in common encode insulin-like peptides and proteins that control insulin metabolism, storage, secretion, and beta cell proliferation, and some not previously linked to insulin production or beta cell function. Among these novelties is unc-104, a Kinesin 3 family gene, which is more highly expressed in IPCs compared to most other neurons. Knockdown of unc-104 in IPCs impaired ILP secretion and reduced peripheral insulin signaling. Unc-104 appears to transport ILPs along axons. As a complementary approach, we tested dominant-negative Rab genes to find Rab proteins required in IPCs for ILP production or secretion. Rab1 was identified as crucial for ILP trafficking in IPCs. Inhibition of Rab1 in IPCs increased circulating sugar levels, delayed development, and lowered weight and body size. Immunofluorescence labeling of Rab1 showed its tight association with ILP2 in the Golgi of IPCs. Unc-104 and Rab1 join other proteins required for ILP transport in IPCs.
Genetics 02/2014;
· 4.39 Impact Factor
Available from: PubMed Central
A Rapid and Simple Method for DNA Engineering Using Cycled Ligation Assembly.
Theodore L Roth
Ljiljana Milenkovic
, Matthew P Scott
[Show abstract]
[Hide abstract]
DNA assembly techniques have developed rapidly, enabling efficient construction of complex constructs that would be prohibitively difficult using traditional restriction-digest based methods. Most of the recent methods for assembling multiple DNA fragments in vitro suffer from high costs, complex set-ups, and diminishing efficiency when used for more than a few DNA segments. Here we present a cycled ligation-based DNA assembly protocol that is simple, cheap, efficient, and powerful. The method employs a thermostable ligase and short Scaffold Oligonucleotide Connectors (SOCs) that are homologous to the ends and beginnings of two adjacent DNA sequences. These SOCs direct an exponential increase in the amount of correctly assembled product during a reaction that cycles between denaturing and annealing/ligating temperatures. Products of early cycles serve as templates for later cycles, allowing the assembly of many sequences in a single reaction. To demonstrate the method's utility, we directed the assembly of twelve inserts, in one reaction, into a transformable plasmid. All the joints were precise, and assembly was scarless in the sense that no nucleotides were added or missing at junctions. Simple, efficient, and low-cost cycled ligation assemblies will facilitate wider use of complex genetic constructs in biomedical research.
PLoS ONE 01/2014; 9(9):e107329.
· 3.53 Impact Factor
Wing Tips: The wing disc as a platform for studying Hedgehog signaling
Tom A. Hartl
, Matthew P. Scott
[Show abstract]
[Hide abstract]
Hedgehog (Hh) signal transduction is necessary for the development of most mammalian tissues and can go awry and cause birth defects or cancer. Hh signaling was initially described in Drosophila, and much of what we know today about mammalian Hh signaling was directly guided by discoveries in the fly. Indeed, Hh signaling is a wonderful example of the use of non-vertebrate model organisms to make basic discoveries that lead to new disease treatment. The first pharmaceutical to treat hyperactive Hh signaling in Basal Cell Carcinoma was released in 2012, approximately 30 years after the isolation of Hh mutants in Drosophila. The study of Hh signaling has been greatly facilitated by the imaginal wing disc, a tissue with terrific experimental advantages. Studies using the wing disc have led to an understanding of Hh ligand processing, packaging into particles for transmission, secretion, reception, signal transduction, target gene activation, and tissue patterning. Here we describe the imaginal wing disc, how Hh patterns this tissue, and provide methods to use wing discs to study Hh signaling in Drosophila. The tools and approaches we highlight form the cornerstone of research efforts in many laboratories that use Drosophila to study Hh signaling, and are essential for ongoing discoveries.
Methods 01/2014;
· 3.64 Impact Factor
Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma.
Melanie G Hayden Gephart
Yourong Sophie Su
Samuel Bandara
Feng-Chiao Tsai
Jennifer Hong
Nicholas Conley
Helen Rayburn
Ljiljana Milenkovic
Tobias Meyer
, Matthew P Scott
[Show abstract]
[Hide abstract]
The Hedgehog (Hh) signaling pathway has been implicated in the most common childhood brain tumor, medulloblastoma (MB). Given the toxicity of post-surgical treatments for MB, continued need exists for new, targeted therapies. Based upon our finding that Neuropilin (Nrp) transmembrane proteins are required for Hh signal transduction, we investigated the role of Nrp in MB cells. Cultured cells derived from a mouse Ptch (+/-) ;LacZ MB (Med1-MB), effectively modeled the Hh pathway-related subcategory of human MBs in vitro. Med1-MB cells maintained constitutively active Hh target gene transcription, and consistently formed tumors within one month after injection into mouse cerebella. The proliferation rate of Med1-MBs in culture was dependent upon Nrp2, while reducing Nrp1 function had little effect. Knockdown of Nrp2 prior to cell implantation significantly increased mouse survival, compared to transfection with a non-targeting siRNA. Knocking down Nrp2 specifically in MB cells avoided any direct effect on tumor vascularization. Nrp2 should be further investigated as a potential target for adjuvant therapy in patients with MB.
Journal of Neuro-Oncology 09/2013;
· 3.12 Impact Factor
Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma.
Sarah J Moore
Melanie G Hayden Gephart
Jamie M Bergen
Yourong S Su
Helen Rayburn
, Matthew P Scott,
Jennifer R Cochran
[Show abstract]
[Hide abstract]
Central nervous system tumors carry grave clinical prognoses due to limited effectiveness of surgical resection, radiation, and chemotherapy. Thus, improved strategies for brain tumor visualization and targeted treatment are critically needed. We demonstrate that mouse cerebellar medulloblastoma (MB) can be targeted and illuminated with a fluorescent, engineered cystine knot (knottin) peptide that binds with high affinity to αvβ3, αvβ5, and α5β1 integrin receptors. This integrin-binding knottin peptide, denoted EETI 2.5F, was evaluated as a molecular imaging probe in both orthotopic and genetic models of MB. Following tail vein injection, fluorescence arising from dye-conjugated EETI 2.5F was localized to the tumor compared with the normal surrounding brain tissue, as measured by optical imaging. The imaging signal intensity correlated with tumor volume. Due to its unique ability to bind to α5β1 integrin, EETI 2.5F showed superior in vivo and ex vivo brain tumor imaging contrast compared with other engineered integrin-binding knottin peptides and with c(RGDfK), a well-studied integrin-binding peptidomimetic. Next, EETI 2.5F was fused to an antibody fragment crystallizable (Fc) domain (EETI 2.5F-Fc) to determine if a larger integrin-binding protein could also target intracranial brain tumors. EETI 2.5F-Fc, conjugated to a fluorescent dye, illuminated MB following i.v. injection and was able to distribute throughout the tumor parenchyma. In contrast, brain tumor imaging signals were not detected in mice injected with EETI 2.5F proteins containing a scrambled integrin-binding sequence, demonstrating the importance of target specificity. These results highlight the potential of using EETI 2.5F and EETI 2.5-Fc as targeted molecular probes for brain tumor imaging.
Proceedings of the National Academy of Sciences 08/2013;
· 9.81 Impact Factor
Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C.
Manuel E Lopez
, Matthew P Scott
[Show abstract]
[Hide abstract]
Understanding neurodegenerative disease progression and its treatment requires the systematic characterization and manipulation of relevant cell types and molecular pathways. The neurodegenerative lysosomal storage disorder Niemann-Pick disease type C (NPC) is highly amenable to genetic approaches that allow exploration of the disease biology at the organismal, cellular and molecular level. Although NPC is a rare disease, genetic analysis of the associated neuropathology promises to provide insight into the logic of disease neural circuitry, selective neuron vulnerability and neural-glial interactions. The ability to control the disorder cell-autonomously and in naturally occurring spontaneous animal models that recapitulate many aspects of the human disease allows for an unparalleled dissection of the disease neurobiology in vivo. Here, we review progress in mouse-model-based studies of NPC disease, specifically focusing on the subtype that is caused by a deficiency in NPC1, a sterol-binding late endosomal membrane protein involved in lipid trafficking. We also discuss recent findings and future directions in NPC disease research that are pertinent to understanding the cellular and molecular mechanisms underlying neurodegeneration in general.
Disease Models and Mechanisms 08/2013;
· 4.96 Impact Factor
Regulation of Ribosome Biogenesis by Nucleostemin 3 Promotes Local and Systemic Growth in Drosophila.
Tom A Hartl
Julie Ni
Jian Cao
Kaye L Suyama
Stephanie Patchett
Cyril Bussiere
Dan Yi Gui
Sheng Tang
Daniel D Kaplan
Matthew Fish
Arlen W Johnson
, Matthew P Scott
[Show abstract]
[Hide abstract]
Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell autonomous and non-cell autonomous growth control roles of NS3 in Drosophila, and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, demonstrate the necessity of NS3 for cell autonomous growth. A hypomorphic allele highlights the hypersensitivity of neurons to lowered NS3 function. We propose that NS3 is the functional ortholog of yeast and human Lsg1, which promotes release of the nuclear export adapter from the large ribosomal subunit. Release of the adapter and its recycling to the nucleus are essential for sustained production of ribosomes. The ribosome biogenesis role of NS3 is essential for proper rates of translation in all tissues and is necessary for functions of growth-promoting neurons.
Genetics 02/2013;
· 4.39 Impact Factor
Available from: Q. Tian Wang
The chromatin remodeling factor Chd1l is required in the preimplantation embryo.
Alyssa C Snider
Denise Leong
Q Tian Wang
Joanna Wysocka
Mylene W M Yao
, Matthew P Scott
[Show abstract]
[Hide abstract]
During preimplantation development, the embryo must establish totipotency and enact the earliest differentiation choices, processes that involve extensive chromatin modification. To identify novel developmental regulators, we screened for genes that are preferentially transcribed in the pluripotent inner cell mass (ICM) of the mouse blastocyst. Genes that encode chromatin remodeling factors were prominently represented in the ICM, including Chd1l, a member of the Snf2 gene family. Chd1l is developmentally regulated and expressed in embryonic stem (ES) cells, but its role in development has not been investigated. Here we show that inhibiting Chd1l protein production by microinjection of antisense morpholinos causes arrest prior to the blastocyst stage. Despite this important function in vivo, Chd1l is non-essential for cultured ES cell survival, pluripotency, or differentiation, suggesting that Chd1l is vital for events in embryos that are distinct from events in ES cells. Our data reveal a novel role for the chromatin remodeling factor Chd1l in the earliest cell divisions of mammalian development.
Biology open. 02/2013; 2(2):121-31.
Kif3a is Necessary for Initiation and Maintenance of Medulloblastoma.
Monique T Barakat
Eric W Humke
, Matthew P Scott
[Show abstract]
[Hide abstract]
Medulloblastoma (MB) cells arise from granule neuron precursors (GNPs) that have lost growth control. During normal development, GNPs divide in response to Sonic hedgehog (SHH), a ligand that binds to the Patched (PTCH) receptor on GNPs. If one copy of the Ptch gene is lost, as in human Gorlin's syndrome and in Ptch(+/-) mice, MBs may form. Proper transduction of the SHH signal critically depends on primary cilia. Loss of primary cilia results in improper signal reception and failure to properly activate SHH target genes. KIF3a, part of a kinesin motor, is required for formation of primary cilia. Here we use tamoxifen-induced ablation of Kif3a in GNPs of postnatal Ptch(+/-) mouse cerebella to show that KIF3a is necessary for MB formation. To investigate the importance of primary cilia in established tumors, we deleted Kif3a from cultured cells and from tumor cell grafts. The loss of Kif3a from established tumors led to their growth arrest and regression. MBs behave as if they are addicted to the presence of primary cilia. These results underscore the potential utility of agents that disrupt cilia for treatment of Hh pathway-related MBs.
Carcinogenesis 02/2013;
· 5.64 Impact Factor
Microtubules Enable the Planar Cell Polarity of Airway Cilia.
Eszter K Vladar
Roy D Bayly
Ashvin M Sangoram
, Matthew P Scott,
Jeffrey D Axelrod
[Show abstract]
[Hide abstract]
BACKGROUND: Airway cilia must be physically oriented along the longitudinal tissue axis for concerted, directional motility that is essential for proper mucociliary clearance. RESULTS: We show that planar cell polarity (PCP) signaling specifies directionality and orients respiratory cilia. Within all airway epithelial cells, a conserved set of PCP proteins shows interdependent, asymmetric junctional localization; nonautonomous signaling coordinates polarization between cells; and a polarized microtubule (MT) network is likely required for asymmetric PCP protein localization. We find that basal bodies dock after polarity of PCP proteins is established and are polarized nearly simultaneously, and that refinement of basal body/cilium orientation continues during airway epithelial development. Unique to mature multiciliated cells, we identify PCP-regulated, planar polarized MTs that originate from basal bodies and interact, via their plus ends, with membrane domains associated with the PCP proteins Frizzled and Dishevelled. Disruption of MTs leads to misoriented cilia. CONCLUSIONS: A conserved PCP pathway orients airway cilia by communicating polarity information from asymmetric membrane domains at the apical junctions, through MTs, to orient the MT and actin-based network of ciliary basal bodies below the apical surface.
Current biology: CB 10/2012;
· 10.99 Impact Factor
Available from: Andres Klein
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C.
Manuel E Lopez
Andres D Klein
, Matthew P Scott
[Show abstract]
[Hide abstract]
BACKGROUND: The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency) impeded the elimination of apoptotic neurons, allowing survival. In the genetic lysosomal storage disease Niemann-Pick C (NPC), caused by loss of NPC1 function, the expression of complement system components, C1q especially, is elevated in degenerating brain regions of Npc1-/- mice. Here we test whether complement is mediating neurodegeneration in NPC disease. FINDINGS: In normal mature mice, C1q mRNA was found in neurons, particularly cerebellar Purkinje neurons (PNs). In Npc1-/- mice, C1q mRNA was additionally found in activated microglia, which accumulate during disease progression and PN loss. Interestingly, C1q was not enriched on or near degenerating neurons. Instead, C1q was concentrated in other brain regions, where it partially co-localized with a potential C1q inhibitor, chondroitin sulfate proteoglycan (CSPG). Genetic deletion of C1q, or of the downstream complement pathway component C3, did not significantly alter patterned neuron loss or disease progression. Deletion of other immune response factors, a Toll-like receptor, a matrix metalloprotease, or the apoptosis facilitator BIM, also failed to alter neuron loss. CONCLUSION: We conclude that complement is not involved in the death and clearance of neurons in NPC disease. This study supports a view of neuroinflammation as a secondary response with non-causal relationship to neuron injury in the disease. This disease model may prove useful for understanding the conditions in which complement and immunity do contribute to neurodegeneration in other disorders.
Journal of Neuroinflammation 09/2012; 9(1):216.
· 4.35 Impact Factor
Available from: Mili Jeon
Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila.
Mili Jeon
, Matthew P Scott,
Kai Zinn
[Show abstract]
[Hide abstract]
The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system. We previously described a unique embryonic tracheal tubulogenesis phenotype caused by loss of both of the Type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D. In Ptp4E Ptp10D double mutants, the linear tubes in unicellular and terminal tracheal branches are converted into bubble-like cysts that incorporate apical cell surface markers. This tube geometry phenotype is modulated by changes in the activity or expression of the epidermal growth factor receptor (Egfr) tyrosine kinase (TK). Ptp10D physically interacts with Egfr. Here we demonstrate that the Ptp4E Ptp10D phenotype is the consequence of the loss of negative regulation by the RPTPs of three growth factor receptor TKs: Egfr, Breathless and Pvr. Reducing the activity of any of the three kinases by tracheal expression of dominant-negative mutants suppresses cyst formation. By competing dominant-negative and constitutively active kinase mutants against each other, we show that the three RTKs have partially interchangeable activities, so that increasing the activity of one kinase can compensate for the effects of reducing the activity of another. This implies that SH2-domain downstream effectors that are required for the phenotype are likely to be able to interact with phosphotyrosine sites on all three receptor TKs. We also show that the phenotype involves increases in signaling through the MAP kinase and Rho GTPase pathways.
Biology open. 06/2012; 1(6):548-58.
Available from: Andres Klein
Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C.
Manuel E Lopez
Andrés D Klein
Jennifer Hong
Ubah J Dimbil
, Matthew P Scott
[Show abstract]
[Hide abstract]
Chronic systemic inflammation is thought to be a major contributor to metabolic and neurodegenerative diseases. Since inflammatory components are shared among different disorders, targeting inflammation is an attractive option for mitigating disease. To test the significance of inflammation in the lipid storage disorder (LSD) Niemann-Pick C (NPC), we deleted the macrophage inflammatory gene Mip1a/Ccl3 from NPC diseased mice. Deletion of Ccl3 had been reported to delay neuronal loss in Sandhoff LSD mice by inhibiting macrophage infiltration. For NPC mice, in contrast, deleting Ccl3 did not retard neurodegeneration and worsened the clinical outcome. Depletion of visceral tissue macrophages also did not alter central nervous system (CNS) pathology and instead increased liver injury, suggesting a limited macrophage infiltration response into the CNS and a beneficial role of macrophage activity in visceral tissue. Prevention of neuron loss or liver injury, even at late stages in the disease, was achieved through specific rescue of NPC disease in neurons or in liver epithelial cells, respectively. Local epithelial cell correction was also sufficient to reduce the macrophage-associated pathology in lung tissue. These results demonstrate that elevated inflammation and macrophage activity does not necessarily contribute to neurodegeneration and tissue injury, and LSD defects in immune cells may not preclude an appropriate inflammatory response. We conclude that inflammation remains secondary to neuronal and epithelial cell dysfunction and does not irreversibly contribute to the pathogenic cascade in NPC disease. Without further exploration of possible beneficial roles of inflammatory mediators, targeting inflammation may not be therapeutically effective at ameliorating disease severity.
Human Molecular Genetics 04/2012; 21(13):2946-60.
· 7.69 Impact Factor
Available from: James Kenneth Chen
Neuropilins are positive regulators of Hedgehog signal transduction.
R Tyler Hillman
Brian Y Feng
Jun Ni
Wei-Meng Woo
Ljiljana Milenkovic
Melanie G Hayden Gephart
Mary N Teruel
Anthony E Oro
James K Chen
, Matthew P Scott
[Show abstract]
[Hide abstract]
The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane proteins with roles in axon guidance and vascular endothelial growth factor (VEGF) signaling, are important positive regulators of Hh signal transduction. Nrps are expressed at times and locations of active Hh signal transduction during mouse development. Using cell lines lacking key Hh pathway components, we show that Nrps mediate Hh transduction between activated Smoothened (Smo) protein and the negative regulator Suppressor of Fused (SuFu). Nrp1 transcription is induced by Hh signaling, and Nrp1 overexpression increases maximal Hh target gene activation, indicating the existence of a positive feedback circuit. The regulation of Hh signal transduction by Nrps is conserved between mammals and bony fish, as we show that morpholinos targeting the Nrp zebrafish ortholog nrp1a produce a specific and highly penetrant Hh pathway loss-of-function phenotype. These findings enhance our knowledge of Hh pathway regulation and provide evidence for a conserved nexus between Nrps and this important developmental signaling system.
Genes & development 11/2011; 25(22):2333-46.
· 12.08 Impact Factor
Available from: eurekalert.org
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.
Dadi Jiang
Colleen A Brady
Thomas M Johnson
Eunice Y Lee
Eunice J Park
, Matthew P Scott,
Laura D Attardi
[Show abstract]
[Hide abstract]
Over half of all human cancers, of a wide variety of types, sustain mutations in the p53 tumor suppressor gene. Although p53 limits tumorigenesis through the induction of apoptosis or cell cycle arrest, its molecular mechanism of action in tumor suppression has been elusive. The best-characterized p53 activity in vitro is as a transcriptional activator, but the identification of numerous additional p53 biochemical activities in vitro has made it unclear which mechanism accounts for tumor suppression. Here, we assess the importance of transcriptional activation for p53 tumor suppression function in vivo in several tissues, using a knock-in mouse strain expressing a p53 mutant compromised for transcriptional activation, p53(25,26). p53(25,26) is severely impaired for the transactivation of numerous classical p53 target genes, including p21, Noxa, and Puma, but it retains the ability to activate a small subset of p53 target genes, including Bax. Surprisingly, p53(25,26) can nonetheless suppress tumor growth in cancers derived from the epithelial, mesenchymal, central nervous system, and lymphoid lineages. Therefore, full transactivation of most p53 target genes is dispensable for p53 tumor suppressor function in a range of tissue types. In contrast, a transcriptional activation mutant that is completely defective for transactivation, p53(25,26,53,54), fails to suppress tumor development. These findings demonstrate that transcriptional activation is indeed broadly critical for p53 tumor suppressor function, although this requirement reflects the limited transcriptional activity observed with p53(25,26) rather than robust transactivation of a full complement of p53 target genes.
Proceedings of the National Academy of Sciences 10/2011; 108(41):17123-8.
· 9.81 Impact Factor
Available from: sciencedirect.com
The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis.
Chao Wang
Zhiguo Ma
, Matthew P Scott,
Xun Huang
[Show abstract]
[Hide abstract]
Niemann-Pick C (NPC) disease is a lethal neurodegenerative disorder affecting cellular sterol trafficking. Besides neurodegeneration, NPC patients also exhibit other pleiotropic conditions, indicating that NPC protein is required for other physiological processes. Previous studies indicated that a sterol shortage that in turn leads to a shortage of steroid hormones (for example, ecdysone in Drosophila) is likely to be the cause of NPC disease pathology. We have shown that mutations in Drosophila npc1, one of the two NPC disease-related genes, leads to larval lethal and male infertility. Here, we reported that npc1 mutants are defective in spermatogenesis and in particular in the membrane-remodeling individualization process. Interestingly, we found that ecdysone, the steroid hormone responsible for the larval lethal phenotype in npc1 mutants, is not required for individualization. However, supplying 7-dehydrocholesterol can partially rescue the male infertility of npc1 mutants, suggesting that a sterol shortage is responsible for the spermatogenesis defects. In addition, the individualization defects of npc1 mutants were enhanced at high temperature, suggesting that the sterol shortage may lead to temperature-sensitive defects in the membrane-remodeling process. Together, our study reveals a sterol-dependent, ecdysone-independent mechanism of NPC1 function in Drosophila spermatogenesis.
Developmental Biology 03/2011; 351(1):146-55.
· 3.87 Impact Factor
Available from: Andres Klein
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder.
Manuel E Lopez
Andres D Klein
Ubah J Dimbil
, Matthew P Scott
[Show abstract]
[Hide abstract]
Niemann-Pick type C disease is a fatal lysosomal storage disorder caused by loss of NPC1 function. The disorder severely affects multiple body systems, particularly the nervous system. To test whether rescue of NPC1 activity in neurons, astrocytes, or other cell types can correct the neurological defects, a Tet-inducible Npc1-YFP transgene was introduced into Npc1(-/-) mice for the cell type-specific rescue of NPC1 loss. NPC1-YFP produced in neurons prevented neuron degeneration, slowed reactive glial activity, and ameliorated the disease. NPC1-YFP produced in astrocytes or in cells of visceral tissue did not. These results suggest that loss of NPC1 activity from neurons is the primary cause of the neuropathology and that rescue of NPC1 function in neurons is sufficient to mitigate the disease. The ability of neurons to survive and function in a cell-autonomous fashion allowed the use of this newly engineered rescue system to further define the brain regions or neuron populations required to ameliorate a neurological symptom. NPC1-YFP produced specifically in cerebellar Purkinje neurons reduced ataxia, increased weight, and prolonged life, but it did not prevent the eventual decline and premature death of Npc1(-/-) mice. Significant increase in lifespan correlated with sustained reduction of inflammation in the thalamus. Neuron rescue of other forebrain areas provided little benefit. Future work targeting increasingly discrete neuronal networks should reveal which CNS areas are critical for survival. This work may have broad implications for understanding the anatomical and cellular basis of neurological signs and symptoms of other neurodegenerative and lysosomal disorders.
Journal of Neuroscience 03/2011; 31(12):4367-78.
· 6.91 Impact Factor
Available from: Diane C Slusarski
Mutations in prickle orthologs cause seizures in flies, mice, and humans.
Hirotaka Tao
J Robert Manak
Levi Sowers
Xue Mei
Hiroshi Kiyonari
Takaya Abe
Nader S Dahdaleh
Tian Yang
Shu Wu
Shan Chen
, [......],
Hatem El-Shanti
Vinit B Mahajan
Polly J Ferguson
Jeffrey D Axelrod
Anna-Elina Lehesjoki
Bernd Fritzsch
Diane C Slusarski
John Wemmie
Naoto Ueno
Alexander G Bassuk
[Show abstract]
[Hide abstract]
Epilepsy is heritable, yet few causative gene mutations have been identified, and thus far no human epilepsy gene mutations have been found to produce seizures in invertebrates. Here we show that mutations in prickle genes are associated with seizures in humans, mice, and flies. We identified human epilepsy patients with heterozygous mutations in either PRICKLE1 or PRICKLE2. In overexpression assays in zebrafish, prickle mutations resulted in aberrant prickle function. A seizure phenotype was present in the Prickle1-null mutant mouse, two Prickle1 point mutant (missense and nonsense) mice, and a Prickle2-null mutant mouse. Drosophila with prickle mutations displayed seizures that were responsive to anti-epileptic medication, and homozygous mutant embryos showed neuronal defects. These results suggest that prickle mutations have caused seizures throughout evolution.
The American Journal of Human Genetics 02/2011; 88(2):138-49.
· 11.20 Impact Factor
Available from: stanford.edu
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.
Monique T Barakat
Eric W Humke
, Matthew P Scott
[Show abstract]
[Hide abstract]
The Hedgehog (Hh) cascade controls cell proliferation, differentiation and patterning of tissues during embryogenesis but is largely suppressed in the adult. The Hh pathway can become reactivated in cancer. Here, we assimilate data from recent studies to understand how and when the Hh pathway is turned on to aid the neoplastic process. Hh signaling is now known to have a role in established tumors, enabling categorization of tumors based on the role Hh signaling plays in their growth. This categorization has relevance for prognosis and targeted therapeutics. In the first category, abnormal Hh signaling initiates the tumor. In the second category, Hh signaling helps maintain the tumor. In the third category, Hh signaling is implicated but its role is not yet defined.
Trends in Molecular Medicine 08/2010; 16(8):337-48.
· 9.57 Impact Factor
Available from: ncbi.nlm.nih.gov
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.
Qicong Hu
Ljiljana Milenkovic
Hua Jin
, Matthew P Scott,
Maxence V Nachury
Elias T Spiliotis
W James Nelson
[Show abstract]
[Hide abstract]
In animal cells, the primary cilium transduces extracellular signals through signaling receptors localized in the ciliary membrane, but how these ciliary membrane proteins are retained in the cilium is unknown. We found that ciliary membrane proteins were highly mobile, but their diffusion was impeded at the base of the cilium by a diffusion barrier. Septin 2 (SEPT2), a member of the septin family of guanosine triphosphatases that form a diffusion barrier in budding yeast, localized at the base of the ciliary membrane. SEPT2 depletion resulted in loss of ciliary membrane protein localization and Sonic hedgehog signal transduction, and inhibited ciliogenesis. Thus, SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium.
Science 07/2010; 329(5990):436-9.
· 31.20 Impact Factor
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Stanford University
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European Molecular Biology Laboratory
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Weizmann Institute of Science
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text:
The high-end electric car manufacturer Tesla Motors prevailed in a lawsuit filed by Massachusetts auto dealers in an attempt to stop the company from selling directly off the assembly line to customer.
Former U.S. Congressman William Delahunt has resigned from the nonprofit company he started in hopes of opening three medical marijuana dispensaries in southeastern Massachusetts, including one in Plymouth.
The Coyle-Cassidy and Bristol-Plymouth boys soccer teams each could have stole the show on Monday.
The state's Department of Transportation is footing the bill for the replacement of a 66-year-old two-lane, overpass-style bridge on Washington Street.
Chris Moulding said organizing a 5K race to raise money for a Taunton nonprofit that builds custom houses for severely injured military vets is well worth the effort.
BLACKSTONE - Hundreds of people gathered on the playing fields at John F. Kennedy Elementary School Sunday evening to pay a somber respect to the four children taken from a Blackstone home in late August and the three lives that...
The obituaries for the Taunton Daily Gazette for Sept. 16, 2014
With a change in the governorship a few months away, a fledgling business group with influential members has organized and is gaining steam to help ensure the $2.3 billion South Coast Rail project stays on track into South Station.
If you've been living under a rock, don't own a radio or a television, or have somehow been lucky enough to remain blissfully ignorant of the recent shenanigans of singer�
Patriots head coach Bill Belichick and his players agree that there's room for improvement following Sunday's 30-7 victory over the Minnesota Vikings.
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- Events Calendar


text:
4/23/2008 (6 years ago)
Catholic News Service (www.catholicnews.com)
NEW YORK (CNS) -- "Baby Mama" (Universal/Relativity) is a frequently funny but morally problematic romantic comedy about one woman's obsession with having a child.
Catholic News Service (www.catholicnews.com)
4/23/2008 (6 years ago)
Published in Movies
Thirty-seven and single, hard-driving grocery chain executive Kate (Tina Fey), who has long put career ahead of family, has begun to hear her biological clock tolling. Discovering that adoption could take as long as five years, she tries artificial insemination. When this fails, she consults an obstetrician who tells her that her chances of conceiving are one in a million.
Not to be deterred, she turns to Chaffee (Sigourney Weaver), the imposing head of a surrogate mother agency, and is soon visited by the, shall we say, unpolished Angie (Amy Poehler), who, at the urging of deadbeat common-law husband Carl (Dax Shepard), eventually agrees to bear the child.
When she and Carl temporarily split, Kate takes in Angie as a roommate, with predictable "Odd Couple" consequences. Love, meanwhile, finds its way into Kate's life in the person of ex-lawyer -- now juice-bar owner -- Rob (Greg Kinnear).
Writer-director Michael McCullers' partially improvised feature debut, with a cast that also includes Steve Martin as Kate's dippy boss, abounds in comic energy. But for most of its running time, the film implicitly accepts current mores regarding fertility that are contrary to Catholic values.
Procedures such as artificial insemination and surrogate motherhood inevitably separate the unitive and procreative aspects of human sexuality and may remove procreation from its God-given context of committed marital love. Here, they are accorded the status of acceptable alternatives to natural conception, even if -- forgive the partial spoiler -- the ending manages to skirt most of these issues.
The film contains acceptability of surrogate parenting and artificial insemination, implied premarital sex, some crude and crass language, sexual and scatological humor, and a drug reference. The USCCB Office for Film & Broadcasting classification is O -- morally offensive. The Motion Picture Association of America rating is PG-13 -- parents strongly cautioned. Some material may be inappropriate for children under 13.
Copyright (c) 2007 Catholic News Service/U.S. Conference of Catholic Bishops
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By Catholic Online (NEWS CONSORTIUM)
The science-fiction hit film "Interstellar" has audiences wondering - is "wormhole travel' possible? According to renowned astrophysicist Kip Thorne of the California Institute of Technology in Pasadena - not very likely. Thorne should know as he served as the ... continue reading
By Catholic Online (NEWS CONSORTIUM)
Walt Disney's "Big Hero 6" is cleaning up at the box office. The feature-length animated film features a robot named Baymax who is part "Ghostbusters" Stay-Puft Man and tire mascot the Michelin Man. Cute, fluffy white and adorable, Baymax comes to a rather sad ... continue reading
By Robert Mullen (NEWS CONSORTIUM)
"If He is in your dreams, nothing can stand against them," says the tagline of the new movie "The Identical". It's a simple phrase, but in this drama set primarily against the backdrop of the rise of rock and roll through the '50s and the '60s it still manages to ... continue reading
By Catholic Online - (NEWS CONSORTIUM)
Walt Disney Studios is pulling "Frozen," their animated box-office champ of last year for a fun new movie short. In a title that is the quintessence of contradiction, the new film is entitled "Frozen Fever." LOS ANGELES, CA (Catholic Online) - "Frozen Fever" ... continue reading
By Caitlin Bootsma
Do you ever wonder why Hollywood stopped producing movies like It's a Wonderful Life, Meet Me in St. Louis, or The Wizard of Oz? These were films that you could enjoy viewing by yourself, but also watch with your children or parents without skipping scandalous scenes ... continue reading
By Catholic Online (NEWS CONSORTIUM)
While he's best known for macho, action dramas such as "Taxi Driver," "Raging Bull" and Goodfellas," movie director Martin Scorsese's previous work has always been steeped in the teachings of the Catholic Church. Now, America's finest living motion picture ... continue reading
By Catholic Online (NEWS CONSORTIUM)
Actor James Shigeta, whose most recent high-profile acting role was in the original "Die Hard" entry, has passed away at the age of 81. Shigeta was a highly active Asian-American actor who paved the way for others, and had a 50-year-plus career that stretched ... continue reading
By Catholic Online (NEWS CONSORTIUM)
The "Transformers" film series in the U.S., is based on a childhood toy favorite where ordinary, commonplace things such as trucks turn into giant robots to do battle. Aimed at children, "Transformers" films are aimed mainly at children and are booked in stadium ... continue reading
By Donald Clark
Relativity Studio's Family Friendly "Earth to Echo" (In theaters Nationwide July 2) will entertain kids of all ages, and provide lots of laughs for parents too! We had an opportunity to pre-screen Earth to Echo with 350 children and their parents at the TLC theatre in ... continue reading
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In spite of the World Cup and the Stanley Cup finals dominating TV airwaves this past weekend, it didn't keep film fans from heading to the theaters in droves. The nation's pick for top flick? The rowdy cop comedy "22 Jump Street," which grossed an impressive ... continue reading


text:
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