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Date: 1925 ca.
Description: A large, two-story wood building with nine over six windows identified as an inn; at the time of the photograph it served as the Butte des Morts Post Offic...
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Description: Aerial view of the 1988 EAA (Experimental Aviation Association) Convention and Fly-in at Wittman Field. On the ground is the Concorde and a B-1 Bomber.
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UPDATE: Survivors of Joplin disaster recall narrow escapes
The manager of a hospital service, a high school principal, families and customers at an IHOP restaurant, including two state legislators, recall where they were when the tornado hit Joplin.
UPDATE: Feds offering home aid following southwest Missouri tornado
Those with homes damaged in Sunday's tornado can receive federal aid for uninsured expenses, including temporary housing.
Task Force 1 finds 'complete devastation' in Joplin
As of 3:15 a.m., the teams from Task Force One were conducting search-and-rescue missions.
UPDATE: Missouri officials say tornado killed at least 89
Houses, churches, schools, businesses and homes were flattened after a tornado hit the city of Joplin on Sunday evening. Officials said at least 89 people were killed and an unknown number of people were injured during the storm.
Joplin residents share stories of devastation
Two Joplin natives tell stories of grief and relief after Sunday evening's tornado.
Columbia organizations mobilize to help Joplin victims
We'll keep a running list of ways you can help. If your group is organizing a relief effort and you're not listed here, let us know. You can e-mail us at email@example.com, send us a tweet @CoMissourian or call 882-5720.
Organizations around Missouri provide relief to Joplin tornado victims
MU Health Care and the American Red Cross Mid-Missouri Chapter have been working to provide relief for the residents of Joplin.
Dispatch from Joplin: Counting themselves grateful
Hertzberg family members count their blessings after boarding up the windows of their damaged Joplin home.
Inside Missouri hospital: a mix of chaos and bravery
Staff at St. John's Regional Medical Center helped patients evacuate after a tornado destroyed much of the building. Patients were then sent to other hospitals for treatment.
VIDEO: See the devastation that hit Joplin
Traditional media and citizen journalists have been uploading videos of the devastation in Joplin to YouTube. Here are a couple of those videos.
Strong storms hit Arkansas; governor offers aid to Missouri
Arkansas offers assistance to Joplin as severe storms tear through state.
Dispatch from Joplin: An unwelcome homecoming
After the tornado leveled her hometown, MU student and Missourian reporter Eliza Smith packed up her car and headed home.
Severe thunderstorm watch issued for Boone County
Boone County is under a severe thunderstorm watch until 6 p.m. Monday. Rainfall is expected through Wednesday.
Joplin native describes living through tornado
MU senior Katy Berryman tells her account of the being in Joplin when the tornado hit Sunday evening.
Attorney general sends examiners to Joplin to check price-gouging
The examiners are there to make sure prices are not being artificially raised for such necessities as food, water and diapers.
MORE COVERAGE: More resources for coverage of the Joplin tornado
Here is a roundup of links providing information about the tornado that hit Joplin.
At least 89 dead in Joplin tornado, officials say
Storm damage reports from Boone County
Hail and wind gusts were seen across central Missouri on Sunday night and Monday morning.
UPDATE: Tornado kills unknown number in Joplin
Tornado warnings has been issued from Texas to Michigan Sunday night, as the unknown death toll continues to rise.

subset: commoncrawl


text:
Human calcitonin in the form of four components and process for their isolation from C-cells material.
1. The .Iadd.substantially pure .Iaddend.dotriacontapeptide amide of the formula ##STR3## its acid addition salts and complexes.
2. A pharmaceutical preparation suitable for treatment of hypercalcaemea, Paget's disease and osteoporosis comprising an effective amount of the dotriacontapeptide amide of the formula ##STR4## .Iadd.
3. The dotriacontapeptide amide of the formula Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 which is substantially free of biological impurities. .Iaddend. .Iadd.4. The dotriacontapeptide amide of the formula Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 which has a distribution coefficient of about 0.6 in a Craig liquid - liquid distribution system of glacial acetic acid, water and n-butanol having a volume to volume ratio of 4:1:5. .Iaddend. .Iadd.5. The dotriacontapeptide amide of the formula Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 which is capable of producing a biological test activity of at least about 100 MRC units per mg in the rat calcium blood level test as described by Kumar. .Iaddend. .Iadd.6. The dotriacontrapeptide amide of the formula Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 which is unitary as determined by thin layer chromatography and electrophoresis. .Iaddend. .Iadd.7. The dotriacontapeptide amide according to claim 6 wherein the thin layer chromatography is on a solid support of aluminum oxide using an eluting system of n-butanol, glacial acetic acid and water and the electrophoresis is on cellulose using an eluting system of glacial acetic
acid, formic acid and water. .Iaddend. .Iadd.8. The dotriacontapeptide amide according to claim 7 wherein the reference standard for chromatographic and electrophoretic measurement of the dotriacontapeptide amide movement is porcine calcitonin. .Iaddend. .Iadd.9. A pharmaceutical preparation suitable for treatment of hypercalcaemia, Paget's disease and osteoporosis comprising an effective amount of the dotriacontapeptide amide of the formula ##STR5##.Iaddend. or its pharmaceutically acceptable acid addition salt or its formulated, activity prolonging complex in a pharmaceutical excipient
suitable for enteral or parenteral administration. .Iadd.10. A pharmaceutical preparation according to claim 9 wherein the dotriacontapeptide amide is substantially pure. .Iaddend. .Iadd.11. A pharmaceutical preparation according to claim 9 wherein the pharmaceutical carrier is mannitol. .Iaddend. .Iadd.12. A pharmaceutically acceptable acid addition salt or a pharmaceutically acceptable formulated, activity prolonging complex of the dotriacontapeptide amide of the formula Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2. .Iaddend. .Iadd.13. A pharmaceutically acceptable salt or complex according to claim 12 wherein the dotriacontapeptide amide is substantially pure. .Iaddend. .Iadd.14. A pharmaceutically acceptable acid addition salt according to
claim 12. .Iaddend. .Iadd.15. A salt according to claim 14 wherein the acid is hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, stearic acid, glycollic acid, lactic acid, pyruvic acid, oxalic acid, citric acid, benzoic acid, cinnamic acid, salicylic acid, 2-phenoxybenzoic acid, 2-acetoxybenzoic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, hydroxyethanesulfonic acid, benzenesulfonic acid, toluenesulfonic acid, trichloroacetic acid or trifluoroacetic acid. .Iaddend. .Iadd.16. A salt according to claim 14 wherein the acid is acetic acid. .Iaddend. .Iadd.17. A pharmaceutically acceptable, formulated activity-prolonging complex according to claim 12. .Iaddend. .Iadd.18. A complex according to claim 17 wherein the complexing substance is nonantigenic gelatin, oxypolygelatin, polyvinyl-pyrrolidone, polyphloretinephosphate phytic acid, protamine, polyglutamic acid, or an inorganic metal compound having a cation selected from aluminum, magnesium, cobalt or zinc and an anion selected from phosphate, pyrophosphate or hydroxide. .Iaddend.
This is a continuation of application Ser. No. 632,928, filed Nov. 18, 1975 (now abandoned), which is a continuation of Ser. No. 488,880, filed July 15, 1974 (now abandoned), which, in turn, is a division of application Ser. No. 253,007, filed May 15, 1972 (now abandoned), which is a continuation of Ser. No. 831,776, filed June 9, 1969 (now abandoned).
The present invention provides new peptides which lower the blood calcium level, their acid addition salts and complexes and a process for their manufacture. These peptides are human calcitonin whose production in pure form, in form of several active components, has been achieved.
It is known that hypocalcaemic hormones occur in mammals and in humans. The structure of porcine thyrocalcitonin has already been explored; it is a dotriacontapeptide amide containing a cystine disulfide ring at the N-terminus. In view of the great importance of calcitonin in the calcium metabolism and in the formation of bones and in the relevant therapy it is important to have human thyrocalcitonin available in pure form. The manufacture of human calcitonin in pure form from C-cell rich medulla carcinoma of the thyroid gland and from C-cell metastasis material has now been accomplished. The process for the manufacture of human calcitonin is characterized in that medullar carcinoma of the thyroid gland or C-cell metastasis material, which has been degreased, for example with acetone or ether, and may have been first extracted with alcohol or with aqueous trichloroacetic acid, is extracted once or repeatedly with a solvent system containing water and a lower alkanol, at a pH value of about 1 to 6, and the resulting solution is worked up in the usual manner as with porcine thyrocalcitonin, especially by gel chromatography with the use of aqueous formic acid as eluant and by Craig distribution with the use of a solvent system containing n-butanol and acetic acid.
The solvent system used for the extraction contains as lower alkanol, for example, methanol, ethanol, propanol, n-butanol or secondary butanol. The water content of the system may vary, for example, from 4 to 50%, preferably from 5 to 30%. The above-mentioned acid pH value is established, for example, with an inorganic acid such as sulfuric or hydrochloric acid, or with an organic acid such as formic or acetic acid, or with an acid buffer such as acetate of citrate buffer. If desired, the solvent system may contain further organic solvents such as acetone, or organic bases such as pyridine or morpholine, and/or inorganic salts such as sodium chloride. Particularly useful are systems containing n-butanol and acetic acid, especially n-butanol+glacial acetic acid+water (75:7.5:21).
The extraction may be performed in several stages with the same or with different solvent systems.
From the extract the crude product is obtained, for example, by evaporation, lyophilization or precipitation, for instance with acetone or trichloroacetic acid.
The chromotographic purification is advantageously carried out on "Sephadex G-50" or on an equivalent material. The elution is performed, for example, with 0.1 N-formic acid.
As mentioned above, the Craig distribution is most advantageously carried out with systems containing n-butanol and acetic acid, for example n-butanol+glacial acetic acid+water (4:1:5).
The main component of human calcitonin (designated herein as HT-C2) is a dotriacontapeptide amide with the following aminoacid sequence: Lys (1), His (1), Asp (3), Thr (5), Ser (1), Glu (2), Pro (2), Gly (4), Ala (2), 1/2 Cys (2), Val (1), Met (1), Ile (1), Leu (2), Tyr (1), Phe (3), 4 of the 5 carboxyl side-chains being in amide form. In addition to it, further active components which are referred to below by HT-C1, HT-C11 and HT-C21 have been isolated in pure form. The aminoacid analysis of HT-C1 is identical with that of HT-C2. Thus, the main component of human calcitonin differs considerably in its aminoacid sequence from that of porcine thyrocalcitonin. When HT-C1 and HT-C2 are enzymatically split with trypsin they form two fragments TrI and TrII having the aminoacid sequence indicated in Table 1 in Example 1.
The components HT-C1, HT-C2, HT-C11 and HT-C21 are unitary in thin layer chromatography and electrophoresis.
it was found that HT-C2 corresponds to the following structural formula: ##STR1## HT-C1 is the dimer of this compound. From the fact that on dansylation of HT-C1 and acid hydrolysis no bis-dansyl-cystine is formed, one can conclude that HT-C1 is an antiparallel dimer.
Under basic conditions, for example with dilute ammonia, or by reduction, for instance with dimercaptoethanol or dithiothreitol at room temperature in aqueous pyridine, HT-C1 is converted into HT-C2.
The components HT-C1 and HT-C2 can be converted into their sulfoxides by known oxidiation, for example with aqueous hydrogen peroxide. The characterization of the sulfoxides is shown in the Examples.
Human calcitonin (components HT-C1, HT-C2, HT-C11 and HT-C21, individually or in any desired mixture) reveals in the rat an activity of about 100 to 200 MRC units per mg (peptide) in the test described by Kumar et al, J. Endocrinology 33, page 470 [1965]. It lowers the plasma calcium level and plasma phosphate level of the blood of mammals, as can be shown by tests on rats weighing 50 to 150 g. In patients with increased bone turn over it lowers the calcium level of the blood on intravenous, intramuscular or subcutaneous injection of 0.01 to 5 mg, for instance in 0.1 molar acetate buffer of pH 4.6. It may therefore be used for the treatment of hypercalcaemiae and of bone diseases such as Paget's disease or osteoporosis.
HT-C1, HT-C2, HT-C11 and HT-C21 are bases capable of forming acid addition salts with inorganic or organic acids. From the acid addition salts the base can be liberated in known manner. For pharmaceutical purposes the base may be converted into therapeutically acceptable acid addition salts, for example into salts with inorganic acids such as hydrohalic acids, for example hydrochloric or hydrobromic acid, nitric, thiocyanic, sulfuric or phosphoric acid, or with organic acids such as acetic, propionic, stearic, glycollic, lactic, pyruvic, oxalic, citric, benzoic, cinnamic, salicylic, 2-phenoxy- or 2-acetoxy-benzoic acid, mandelic, methanesulfonic, ethanesulfonic, hydroxyethanesulfonic, benzene- or toluenesulfonic, trichloro- or trifluoroacetic acid.
Human calcitonin can be converted in known manner into pharmaceutically useful complexes having a prolonged activity, for example complexes with substances that are known to prolong the activity of peptides, such as nonantigenic gelatin, especially oxypolygelatin, polyvinyl-pyrrolidone, polyphloretinephosphate, phytic acid, protamine, polyglutamic acid or sparingly soluble metal compounds, for example phosphates, pyrophosphates or hydroxides of aluminum, magnesium, cobalt or especially zinc.
The salts and complexes are suitable for the same use as the free peptide.
For use in pharmaceutical preparations the new compounds may be mixed with a pharmaceutical organic or inorganic excipient suitable for enteral of parenteral administration. Suitable excipients are, for example, water, physiological saline solutions, gelatin, lactose, glucose, starches, vegetable oils, benzyl alcohols, polyalkyleneglycols and other known pharmaceutical excipients. The preparations may be sterilized and/or contain assistants such as preservatives, stabilizers, wetting agents or emulsifiers. They may also contain further therapeutically valuable additives.
The following Examples illustrate the invention.
In thin-layer chromatography the following systems are used:
______________________________________System______________________________________45 sec-butanol + 3% aqueous ammonia (7:3)52 n-butanol + glacial acetic acid + water (75:7.5:21)79 n-butanol + pyridine + water (1:1:1)101A n-butanol + pyridine + glacial acetic acid + water (42:24:4:30)104 chloroform + methanol + 17% aqueous ammonia (41:41: 18)______________________________________
Unless otherwise indicated, thin-layer chromatography is carried out on Alox D-O (Messrs. Camag). All values (Rs) are referred to porcine α-thyrocalcitonin sulfoxide=1.
Electrophoresis is performed on Avicel cellulose or on Cellogel (cellulose acetate films) at pH=1.9 [with the buffer glacial acetic acid+formic acid+water (95:26.5:980)] at 140 Volt, 2 hours. The distance travelled (d) is referred to porcine α-thyrocalcitonin sulfoxide=1.
10 Grams of medulla carcinoma are immediately deep-frozen and lyophilized. The fatty constituents are removed by extraction with either and the dry tissue (2 g) is thoroughly extracted 3 times with 10 times the volume of a mixture of n-butanol+glacial acetic aicd+water (75:7.5:21) at 20� C. The extracts are combined, in vacuo freed from butanol and lyophilized, to yield 450 mg of a dry residue having an activity of 12 MRC units per mg. 300 mg of this product in 0.1 N-formic acid are purified by gel filtration through a column (450 ml) of Bio Gel P6 or Sephadex G-50 in 0.1 N-formic acid. The active fractions (0.5 to 0.7 column volumes) are combined and lyophilized, to yield 18 mg of a product of 50 MRC units per mg. This material is then subjected to a multiplicative distribution in the system glacial acetic acid+water+butanol (1:5:4) over 140 stages, choosing a phase volume of 3 ml at a phase ratio of 1. The active fractions identified by testing are combined in groups of 10 elements each, freed from the solvent and lyophilized. For the fractions with maximum activity K=0.6. The peptide HT-C2, obtained therefrom is pure according to thin-layer chromatography and electrophoresis. In the rat it displays an activity of about 100-200 MRC units per mg of peptide. The distance travelled, referred to porcine α-thyrocalcitonin sulfoxide, in the system 52 on Alox DO is 1.16; in the system 79 on Alox DO it is 1.79; in the system 104 on Alox DO it is 1.28; in the system 45 on Alox DO it is 1.37. In glacial acetic acid+formic acid+water (95:26.5:980) at pH 1.9 the product travels at 140 volts in 2 hours on Avicel cellulose towards the cathode d=0.77, referred to porcine α-thyrocalcitonin sulfoxide=1.
The produce gives positive color reactions with ninhydrin, chlorotolidine, potassium hexacyanoferrate(II)-iron (III) chloride, diazotized sulfanilic acid amide, no reaction with 4-dimethylaminobenzaldehyde-hydrochloric acid or Sakaguchi reagent; no ultraviolet fluorescence; tryptophan is absent. The aminoacid analysis after acid hydrolysis reveals the following result: Lysine (1), histidine (1), aspartic acid (3), threonine (5), serine (1), glutamic acid (2), proline (2), glycine (4), alanine (2), 1/2 cystine (2), valine (1), methionine (1), isoleucine (1), leucine (2), tyrosine (1), phenylalanine (3), NH3. The sulfoxide of HT-C2 reveals the following values: Rs 52=1.07, Rs 45=1.20, Rs 79=1.66.
For further characterization the enzymatic splitting of the peptide with trypsin is used. There are obtained two fragments, namely TrI containing the aminoacids 1-18, and TrII with the aminoacids 19-32. The aminoacid sequence of the two fragments is shown in Table 1. TrII is in thin-layer chromatography on Alox DO distinctly more lipophilic than TrI and travels in the electrophoresis faster towards the cathode than does TrI.
Fragment TrI : Rs 52=0.53; Rs 79=0.54; Rs 104=0.51.
Electrophoresis on Avicel cellulose: d=0.81.
Fragment TrII : Rs 52=1.38; Rs 79=1.45; Rs 104=1.43.
Electrophoresis on Avicel cellulose: d=0.94.
TABLE 1______________________________________ TrI TrII______________________________________NH3 (3) (2)Lys 1His 1Asp 3Thr 3 2Ser 1Glu 1 1Pro 2Gly 2 2Ala 21/2 Cys 2Val 1Met 1Ile 1Leu 2Tyr 1Phe 1 2 18 14______________________________________
110 Grams of deep-frozen C-cell metastasis material taken from the chest are degreased with ether and then extracted as described in Example 1 with n-butanol+glacial acetic acid+water (75:7.5:21), to furnish 6 g of dry extract as a dark-brown powder, which is repeatedly agitated with 0.1 N-formic acid (total 150 ml), during which 3.6 g of the dry residue pass into solution. The solution is subjected in two portions on a Bio Gel P6 column (5 cm; 85 cm; volume about 1.6 liter) to gel chromatography with 0.1 N-formic acid and collected in fractions of 20 ml each. There are two peaks with active material present, namely in fractions 13-21 with the peak maximum at 0.4 column volume and the fractions 25-34 with the peak maximum at 0.55 column volume. The fractions 25-34 are combined and lyophilized to furnish 105 mg of crude produce which is identical with the product obtained by gel filtration as described in Example 1 and, after multiplicative distribution according to Example 1, furnishes pure HT-C2. The combined fractions 13-21 are lyophilized and furnish 202 mg of crude product which is subjected to a multiplicative distribution in the system n-butanol+glacial acetic acid+water (4:1:5) over 400 stages in elements having a phase volume of 3 ml each. The activity maximum is at K=0.19. The resulting pure product (HT-C1) gives in the rat test according to Kumar et al. (see above) about as good results as the product obtained in Example 1 (HT-C2). It can be converted, for example with 5% hydrogenperoxide, into the equally active sulfoxide. In thin-layer chromatography on Alox DO Rs 52=1.04; Rs 79=1.42; Rs 45=1.20. The sulfoxide reveals the following values: Rs 52=0.88; Rs 79=1.29; Rs 45=1.09. In electrophoresis on Avicel cellulose d=0.90 for HT-C1 and its sulfoxide. On Cellogel d=1.15 for HT-C1 and d=1.35 for its sulfoxide. HT-C1 gives positive reactions with ninhydrin, chlorotolidine, Pauly reagent and Barton's reagent. The reaction according to Sakaguchi and according to Ehrlich and ultraviolet fluorescence are negative.
Aminoacid analysis after acid hydrolysis reveals: Lysine (1), histidine (1), aspartic acid (3), threonine (5), serine (1), glutamic acid (2), proline (2), glycine (4), alanine (2), 1/2 cystin (2), valine (1), methionine (1), isoleucine (1), leucine (2), tyrosine (1), phenylalanine (3), NH3.
By trypsin splitting, two fragments with the same aminoacid sequences as for HT-C2 in Table 1 of Example 1 are obtained. TrII is identical for HT-C1 and HT-C2.
For fragment TrI Rs 52 (on Alox)=0.55; Rs 101 A (on cellulose)=0.86. In electrophoresis on Avicel cellulose d=0.91.
For fragment TrII Rs 52 (on Alox)=1.38; Rs 101 A (on cellulose)=1.31. In electrophoresis on Avicel cellulose d=0.94.
HT-C2 is dissolved in 50 times its own weight of as 0.1% cysteine hydrochloride solution and kept for 1 hour at 45� C., and the solution is then chromatographed. Apart from other products, a spot corresponding to HT-C1 is found.
When HT-C1 is heated with 0.5 N-ammonia for 1 hour at 45� C., it is converted into HT-C2.
When medulla carcinoma is extracted as described in Example 1, the dry residue is purified by gel filtration and the resulting product (containing 50 MRC units/mg) is subjected to a multiplicative distribution at described in Example 1, there are obtained apart from the fractions with a maximum activity K=0.6 fractions with K=2.7. The peptide HT-C21 obtained therefrom is unitary in thin-layer chromatography and electrophoresis. It has the same aminoacid composition as HT-C2, but it has no free α-amino group. It reveals in the rat an activity of about 100-200 MRC units per mg of peptide.
In thin-layer chromatography on Alox DO Rs 52=1.40; Rs 104=1.40; Rs 79=1.80. In the electrophoresis on Avicel cellulose d=0.56.
The product gives positive color reactions with ninhydrin, chlorotolidine, potassium hexacyanoferrate(II)-iron (III) chloride and diazotized sulfanilic acid amide.
When medulla carcinoma is extracted as described in Example 2, the dry residue of the extract purified by gel filtration and the product of fractions 13-21 is subjected to a multiplicative distribution, there are obtained--apart from the active fractions with K=0.19--fractions with K=4.0. The peptide HT-C11 obtained therefrom proves to be unitary in thin-layer chromatography and electrophoresis. In the rat it displays an activity of about 100-200 MRC units per mg of peptide. In thin-layer chromatograpy on Alox DO Rs 52=1.45; Rs 104=1.60; Rs 79=1.60. In the electrophoresis on Avicel cellulose D=0.54. The product gives positive color reactions with ninhydrin, chlorotolidine, potassium hexacyanoferrate (II)-iron(III)chloride and diazotized sulfanilic acid amide.
A solution of 0.5 mg of ##STR2## in 1 ml of an aqueous solution of 20 mg of mannitol and 4.6 mg of formic acid is filtered sterile and under aseptic conditions charged into a 5 ml-ampoule, then deep-cooled and lyophilized. Before use the lyophilizate is dissolved in distilled water. The contents of the ampoule corresponds to about 70 MRC units. The solution is injected intramusclarly or intravenously, for example 10 to 70 MRC-units per day.
A suspension is prepared by dissolving 5.25 mg of ZnCl2 and 1.05 mg of Na2 HPO4.2H2 O in 0.5 ml of 0.1 N hydrochloric acid, adding with stirring a solution of 1.0 mg of calcitonin M-HT-C2 in 0.25 ml of distilled water, then 0.5 N NaOH up to pH 8.6 and filling up to 1 ml with distilled water. The suspension corresponds to about 150 MCR-units. It can be preserved with a suitable preservative, for instance with 10 mg of benzyl alcohol.
The suspension can be used for intramuscular injection, for example 25 to 75 MRC units per day.
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Faint BFP turned to all BFNs.. I'm out again
Find a Conversation
|Fri, 08-12-2011 - 9:34pm
Hi everyone
Thanks for all your warm welcome messages, but looks like I am out already. I got a faint BFP (it came up straight away, there was no doubting it, using FRER) on Thursday, and since then I have done lots of HPTs and they have all been BFNs :( (including more FRERS, FMU, and one other brand). I got my BFP at 12DPO and today is 14DPO and I am due for AF tonight. My temp is still very high, and I am exhausted, my veins are getting stronger, and my sense of smell is still disgustingly strong, but I don't think any of that means anything. I had lots of symptoms earlier - tired, nauseas, sore bbs, way more veins on my bbs, tummy and hips, sense of smell skyrocketed, leg cramps, pale face, white lotiony CM, stretching pains down there at night. BUT I think my body just overreacts to all sorts of things.
There is no way one can go from a faint BFP to all BFNs and for it to be ok, so I am 97% sure it is over and now I need to wait for AF - hope it isn't too far away. I suppose for the sperm to have waited 6 days before conception then it couldn't have been too healthy. Oh well, maybe when we are ready to actually TRY for this baby we want (please let us win the lottery!!) then we will make it happen :) I am tired of my body being pregnant without a baby in there!
Good luck everyone :)
|Sat, 08-13-2011 - 12:16am
|Sat, 08-13-2011 - 3:08pm
|Sun, 08-14-2011 - 10:56am
I'm so sorry =( Hopefully, when you guys are ready to start trying again, it's quick!
|Mon, 08-15-2011 - 2:57pm
|Mon, 08-15-2011 - 8:36pm
Thanks everyone. I had the miscarriage last night so it is definitely over. Thanks for your nice thoughts, it makes a difference.
I am more determined than ever now though to get my life into better order so that we can officially actually make a healthy baby at last. with a more stable and secure Life to come into.
Best of luck everyone :)


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Already worried about Hillary? Still waiting for you to suggest who you might support for president in 2016.<quoted text>
Hillary-Michelle has to be a joke. Hillary is a pathological liar. Michelle had to surrender her law license to avoid prosecution for scamming insurance companies.
That ticket would be a joke.
It's hard for you to be FOR anything when all you can do is whine and fret about things that scare you.


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Member Feeds
Is Spring Here-Ice out in Little Ollie Lake
GUNFLINT TRAIL Celebrates "Two-Line Opener"
Grooming on Banadad Ends for the Season
Break from the Cold Tomorrow-Friday
Very Large Black Cat Sighted
Wound Vets Ski Nordic Trails
Great Early December Snow
11/20/14 - I failed to mention that Sawbill Lake froze over for the season on Monday, November 10th.
11/20/14 - I failed to mention that Sawbill Lake froze over for the season on Monday, November 10th. It would have frozen a few days before that except high winds kept it open.
We've been receiving some great pictures from talented photographers. Dave Brislance is a Lutsen, Minnesota based wildlife photographer. He was kind enough to share some close ups of a bull moose he saw just off the Sawbill Trail back in October. - Bill
Photo by David Brislance.
Photo by David Brislance.
Photo by David Brislance.
FADP: French Press
This is truly a #FavoriteEverydayProduct in my kitchen as I DO use it EVERY. SINGLE. DAY. My mornings start out with a 16 oz. glass of water, followed up a cup of Bulletproof Coffee I take with me for my 15 mile ride to the gym. I use my French Press a little different than the average Joe (pun intended, get it?). I use my press to cold-press my coffee. I have read that cold-pressing coffee cuts the acidity and you won't have the "day old" taste like you do with hot-brewed coffee. (Click here for a great article).
Cold-pressing coffee is uber-easy: put as many grounds to your taste (I use three scoops), add water and let sit for at least 12 hours. While I cold-press, this Minnesota born and raised girl likes her coffee hot. After living off-grid for 10 years, I don't use a microwave much and heat mine in a pan on the stove. (I'll save the reasons why I don't microwave much for another post).
Give the French-press, cold-pressed coffee a try and let me know if you notice a difference in taste and the acid in your stomach.
Winterer's Gathering & Arctic Film Festival this weekend
Celebrate the North this weekend at North House Folk School's Winterer's Gathering & Arctic Film Festival.
The three-day event features presentations, coursework, workshops, a winter tent camp, a gear & ski swap, community dancing, films, featured speakers and more, all focused on the lifeways and cultures in the North.
This year's featured speakers are Katherine Breen, Sarah and Eric McNair-Landry and Erik Boomer who paddled their hand-crafted traditional Inuit sea kayaks 600 miles around southern Baffin Island, retracing a historical migration route.
They will give a presentation about their adventures at 7:30 p.m. Saturday night.
This will be followed by the featured film of the Arctic Film Festival: "Lost in the Barrens" based on a novel by Farley Mowat. The film starts at 9 p.m.
There's lots more to see and do at Winterer's Gathering, however, including a variety of workshops, presentations and more.
Highlights include the the Snowshoe Shuffle Contra Dance with Over the Waterfall (7 p.m. Friday,) the Gear & Ski Swap (10:30 p.m. Saturday) and the Deep Freeze Chili Feed (6 p.m. Saturday) as well as ongoing films about the Arctic and the people who live there, and a wide variety of workshops and presentations.
New this year are "Drop-in Skills"workshops, where participants can sign up and learn a number of skills. On Saturday, the workshops include "Fix your hole-y socks" with Elise Kyllo, "Sharpening Things" with Paul Linden, 3 p.m., and "Making Mittens" with Kurt Buetow at 4 p.m.
On Sunday, Nate Johnson will hold "Meet the Crooked Knife" at 9 a.m. and Emily Derke will teach "Small Game Snaring" at 10 a.m. followed by Mike Schelmeske, "Repurpose Old Tools."
For the complete schedule of events, visit www.northhouse.org.
Another storyteller of the north, author, filmmaker, Olympian and NHL hockey player, Henry Boucha, will speak at the Grand Marais Public Library at 1:30 p.m. Friday. This is a free program about Boucha's life growing up in Warroad, becoming an Olympic and NHL hockey player and how his Ojibwe roots have helped him persevere through challenges and tragedies to become a leader in raising awareness about Native American athletes today. All invited.
Also this Friday, Bill Kienert, the director of 'Project Ice," a film that will shown at 7:30 p.m. at North House during the Arctic Film Festival, will talk about making this film about the Great Lakes on WTIP's The Roadhouse. Also, the EverGreen Grass Band will be on the show to talk about their music and play a few tunes. The program airs from 5-7 p.m.
And this is the weekend for the popular "Holidays in Schroeder" in the West End.
It will be held in two locations: the Cross River Heritage Center and the Schroeder Town Hall from 10 a.m. to 2 p.m. Saturday. A Christmas bazaar will be held at at the Town Hall. Entitled "North County Creations," it will offer a wide variety of handmade arts & crafts for the holiday season.
There will be a holiday sale at the Cross River Heritage Center at the same time and features an an art sale and an exhibit of works by Mary Jane Huggins, Peter Juhl, Kathy Gray-Anderson, Trish Hunter and Tim Ostroot. Mrs. Santa Claus will make an appearance, and there will be lefse and krumkaka demonstrations. The drawing for "Whitesky," a handmade quilt, will be at 2 p.m. The Heritage Center will then close for the season. Free and open to the public.
Fans of NPR's Stuart McLean & the Vinyl Cafe can see him in Thunder Bay this weekend, too. He will be at the Thunder Bay Community Auditorium presenting his Christmas show at 2:30 p.m. (EST) Sunday. Tickets are available online at www.tbca.com.
In other art news, this is the last weekend to see the Members Show at the Grand Marais Art Colony. It closes Sunday, Nov. 23.
This is an exceptional exhibit that showcases the breadth and variety of art work created by Art Colony members. Glass, ceramics, oil, encaustic, sumi-e, watercolor, mono-prints, sculpture, collage and more are featured in the show.
The Art Colony is also featuring extra handmade bowls from the Empty Bowls fundraiser last week in its Gift Shop. They are $10 each. All the proceeds will go to Empty Bowls.
The Art Colony is open from 9 a.m. to 4 p.m. daily.
In Duluth, Lutsen sculptor Tom Christiansen is among 26 artists selected to exhibit in the 60th annual Arrowhead Biennial, which is currently open at the Duluth Art Institute in the Depot in Duluth.
Also at the Duluth Art Institute is an exhibit of Jo Wood's bead paintings, "Meaning of Home" and a fascinating exhibit featuring drawings, notebooks, and source material for George Morrison's masterpieces. The exhibit is entitled "Drawing at the Horizon."
In conjunction with the Duluth Art Institute's exhibit, the North Shore Bank of Commerce is exhibiting "From the Collection," a selection of works by previous winners of the Biennial as well as other selected works. It was curated by John Steffl, the former director of the Duluth Art Institute, and a ceramic artist and fine art photographer as well.
Well-known Minnesota artists like Jim Denomie, Craig Blacklock , Cheng Khee Chee, Cecilia Lieder, Elsie Cook, John Salminen and many more have works in bank's exhibit space.
In his curator's statement, Steffl notes: "Regrettably, there is a troublesome pebble embedded in the psyche of our society: the misguided perception that art cannot exist without a rarified and pristine environment. It is a twisted thought that turns owning and displaying artwork into an unfortunate burden, like caring for an expensive breed of delicate, if not sickly, schnauzer."
He goes on to say that all the artworks in this exhibit have had a life. "They have been placed in offices, showcased in lobbies and tucked away in alcoves … They have been loved (or in some cases endured) by staff and clients, captains of industry as well as everyday folks. And, unquestionably, it is the egalitarian beauty of presenting at at the North Shore Bank of Commerce that makes curating exhibits so attractive. People from all walks of life have the opportunity to experience art in a familiar setting … at their discretion … for free."
In Thunder Bay, the Baggage Building Arts Centre is featuring "Birch Bark Visions" through Nov. 30.
It is a collaborative exhibition of drawings on birch bark by artists Mac Squires, Lisa Winter and Gail Marshall.
The Baggage Building is located at Prince Arthur's Landing in downtown Thunder Bay. Check it out here.
For music this weekend:
Thursday, Nov. 20:
- Gordon Thorne, Gunflint Tavern, 8 p.m.
Friday, Nov. 21:
- EverGreen Grass Band, Gunflint Tavern, 9 p.m.
- Cook County's Most Wanted, Birch Grove Foundation fundraiser, Papa Charlie's, 9:30 p.m.
Saturday, Nov. 22:
- Josh Von Mink, Lutsen Resort, 7 p.m.
- Comedy Show, Grand Portage Lodge & Casino, 8 p.m.
- EverGreen Grass Band, Gunflint Tavern, 9 p.m.
Sunday, Nov. 23:
- Stuart McLean & The Vinyl Cafe's Christmas Show, 2:30 p.m. (EST), Thunder Bay Community Auditorium, Thunder Bay
- Timmy Haus, Gunflint Tavern, 7 p.m.
Wednesday, Nov. 26:
- Open Mic Night, Gunflint Tavern, 6 p.m.
Here is our selection of photographs for this week.
First up, some gorgeous northern lights photos.
And some great wildlife shots.
The first one is by Paul Sundberg.
David Johnson has been taking lots of photographs of bald eagles recently. Here's a stunning one.
Thomas Spence captured this fascinating image of early ice on the Onion River.
And we found two great sunrise shots. Here's one by Bryan Hansel taken on Artist's Point.
And Jamie Rabold caught this gorgeous shot as a 1,000-footer approached the Duluth harbor in swirling sea fog.
Have a great weekend, everyone!
Bike Lanes or Multi-use Trail: Learning More about Highway 61 Concept Designs
As the community has the opportunity to provide feedback on two concept designs for the Highway 61 corridor through Grand Marais, there are many things to consider. This is an important opportunity to shape the future of Grand Marais and each community member has a unique set of experiences and perspectives to share. With this in mind, we're highlighting some of the different features and options in the current concept designs to help encourage individual input on the designs.
One of the differences between the two concept designs is the way bicycles are accommodated: on street bike lanes or a multi-use trail. Each option has its own pros and cons, while both would offer better bicycle accommodations that the current corridor. Even for those of us that do not bike, these designs have benefits for drivers as well.
What are on street bike lanes and multi-use trails?
In Concept Design A, bike lanes provide 5 foot wide dedicated pavement width for bicycle use, created with painted lines on the pavement. In Concept Design B, a multi-use trail provides 12 foot wide dedicated pavement for 2-way pedestrian use including bicycles, separated from the road.
Why would we choose on street bike lanes over a multi-use trail?
Some bicyclists prefer to use the road and bike lanes support the existing and future use of the roadway for bicyclists. The use of bike lanes also separates pedestrian and bicyclist traffic, which can have extra advantages in areas with more foot travel. In parts of the corridor, shared use of a multi-use trail has already been an issue at times with congestion. Road separated multi-use trails create potential driveway crossing conflicts due to limited visibility of the crossing. This can be especially of concern to faster moving cyclists, who are more visible in on street bike lanes. The use of bike lanes on Highway 61 through Grand Marais also replicates an existing bike lane system in the downtown of Grand Marais. In the winter months, on street bike lanes can be plowed with the road, not creating any additional snowplowing demands.
Why would we choose a multi-use trail over on street bike lanes?
A multi-use trail also has its advantages over on street bike lanes. By using the multi-use trail option, we could continue the existing Gitchi Gami State Trail through the length of the corridor on the south side until Broadway, when it could potentially switch back to the north side of the road, creating a continuous multiuse facility through the corridor. This multi-use trail would be two feet wider than the existing multi-use trail, creating more space for a variety of users. A multi-use trail provides a grade separated facility that helps protect pedestrians and bicyclists from vehicles. This may be especially appealing to bicyclists not comfortable with on street riding in the corridor, such as young riders. Multi-use trails, if left unstriped, also do not require the painting upkeep as bike lanes do.
What does this mean for drivers?
The design of the road, intersections, and driveways will help improve circulation and safety by better defining vehicular movements at driveways and bringing some angled intersections to 90 degrees. Both entries into town are designed to better inform drivers they are entering a pedestrian zone where slower speeds are required. The road needs to speak to the drivers not just MPH Signs. This results in a better informed driver and safer driving condition. Existing traffic, from local to heavy commercial, is accounted for in the new road design. Bike lanes help dictate bicycle behavior easing vehicle circulation in general. Better designed crosswalk at the correct locations minimizes arrant erratic pedestrian crossings and improves safety and vehicle circulation.
While these are not all the factors to consider, we hope this will help illuminate some of the benefits and trade-offs that are inherent in making community design decisions.
How can I share my thoughts?
The City of Grand Marais needs your input and not only on whether bike lanes or a multi-use path would be preferable for you. Take a few moments to look at the concept designs and provide your feedback at: www.becausemovingmatters.org/highway61. Feedback will be welcomed until Wednesday, November 26th.
Lake Effect Snow and the Lack of It
We haven't been getting snow dumped on us and it's kind of disappointing. Lutsen, the downhill ski hill in our area, is open but had to make most of their snow. I'm sure they would appreciate four feet of the real stuff right about now. Cross-country skiers are biting at the chomp to hit the trails, including me, but it's going to take a bunch of snow before the trails will open. Why aren't we receiving lake effect snowfall? This article does a great job of explaining the process and if I had to guess at the reason we're not getting big snowfall right now I would say it's because there isn't a big difference between the temperature of the water and the air on the North Shore. What do you think?Science behind the lake effect Ed Russo POSTED: 12:27 PM EST Nov 17, 2014 UPDATED: 12:40 PM EST Nov 17, 2014
It's no doubt that parts of the area are going to be dealing with an intense wintry blast over the next several days causing many headaches. There are other parts of the Great Lakes region, though, that will have it worse.
One key ingredient to lake effect snow is something called fetch. Fetch is the distance wind travels over water. The longer the fetch, the more intense the snow bands.
Since the prevailing wind over this part of the country is usually west to east, the fetch over Lake Michigan is relatively small, although still significant enough to create lake effect snow.
However, Lake Erie and Ontario are oriented more west to east so the prevailing wind matches up with the longest axis of both of those lakes resulting in much longer fetch. It's no surprise that because of this, parts of northwest Pennsylvania and New York are going to be measuring snow in feet!
What about Lake Superior? The west to east distance is even greater than that of Erie or Ontario. Lake Superior is a much colder lake so the difference in air/lake temperature is never as great as it is on Erie and Ontario. The greater the temperature difference between air and water, the greater the instability, and as a result, stronger snow bands develop.
With a north wind Lake Michigan can really produce intense snow bands because the wind will travel along Lake Michigan's longest axis which is a north to south distance of just over 300 miles. This is what generates major lake effect snow events in areas like LaPorte county. Due north winds are far more uncommon, however, than a west wind, since west is prevailing across this part of the country.
Another reason the eastern lakes have enhanced snowfall is because of the very hilly terrain across New York and Pennsylvania. This terrain causes the air to lift (called orographic lift) which results in heavier snow. Northern parts of Michigan, especially the UP, often see enhanced lake effect snow due to the higher terrain in places like the Porcupine Mountains.
Barb Gecas on Cover of Minnesota Trails Magazine
Hestons Lodge and Banadad Trail Association Board member Barb Gecas is on the front cover of the current Minnesota Trails Magazine. Her daughter is following her in the picture.
"Clean" Eggs Benedict? Oh yeah!
Eggs Benedict is one of my all-time favorite restaurant breakfasts. I don't have very often as it is not the most healthiest, but with this "cleaner" option, I may have to try to make at home! This recipe come from Clean Eating Magazine who has a whole section of "Classics Made Clean" where I found this week's #RecipeOfTheWeek.Classic Eggs Benedict with Lemon Basil Hollandaise
By Heather Bainbridge
Serves: 2
Hands-on Time: 25 minutes
Total Time: 25 minutes
- 3 large eggs, divided
- 1/3 cup buttermilk
- 1 tsp arrowroot powder
- 1/2 tsp fresh lemon juice
- 1/2 tsp safflower oil
- 1/8 tsp ground cayenne pepper
- 1 tbsp fresh basil, chopped, plus additional for garnish
- 2 1-oz slices all-natural turkey bacon, no nitrates or nitrites
- 2 1/2-inch-thick slices vine tomato
- 1 whole-grain English muffin, halved and toasted
- Prepare sauce: In a small saucepan on medium, whisk 1 egg, buttermilk, arrowroot, lemon juice, oil and cayenne. Reduce heat to low and cook, whisking often, until thickened, about 15 minutes. Stir in 1 tbsp basil.
- Meanwhile, poach eggs: Fill a medium saucepan with 2 inches water and bring to a simmer. Crack 1 egg into a small cup. With a spoon, make a swirling motion in water and slowly add egg, using spoon to tuck egg white close to yolk. Crack remaining egg into small cup and add to water; repeat tucking motion with egg white. Cook each egg for 4 minutes. With a slotted spoon, remove eggs from water.
- Meanwhile, heat a medium nonstick skillet on medium-high. Add bacon and cook, turning once, until crisp, about 4 minutes per side. Remove bacon from skillet and cut each slice in half; add tomato to skillet and sear, turning once, for 1 to 2 minutes per side. Top English muffin halves with bacon, tomato, egg and hollandaise, dividing evenly. Garnish with additional basil.
Nutrients per serving (1 egg, 1/2 english muffin, 1 slice tomato, 1 slice bacon, 3 1/2 tbsp hollandaise): calories: 251, total fat: 11 g, sat. fat: 3 g, Monounsaturated fat: 4 g, polyunsaturated fat: 3 g, carbs: 18.5 g, fiber: 3 g, sugars: 6 g, protein: 20 g, sodium: 474 mg, cholesterol: 309 mg
Deadline extended for Highway 61 feedback
The deadline for providing feedback on the concept designs for Highway 61 through Grand Marais has been extended until Wednesday, November 26th. Be sure to take advantage of this opportunity to shape the future of Grand Marais, whether you drive, walk, and/or bike. The next public meeting will be held in January.
View concepts and provide feedback at www.becausemovingmatters.org/highway61.
Looking for a Canoe, Kayak or Stand Up Paddle Board?
Our friends in Clearwater, Minnesota may have exactly what you need. They are located just a short drive from the Twin Cities and can set you up with a watercraft you're sure to enjoy. Right now they are entering names of anyone who purchases a boat into a drawing to win a trip to the Boundary Waters, courtesy of Voyageur Canoe Outfitters. This is right in time for the holidays so check them out today!
Wenonah Canoes, Current Designs Kayaks, Pau Hana SUP boards, Jackson Kayaks, Native Watercraft Kayaks, NuCanoe, Liquid Logic Kayaks, Osagian Canoes, and periodically we get other used brands in.
Kratt Chat: Get your MOVE ON!
Get your MOVE ON! From tradeshows, festivals to movie theatres, you will find us busting out everywhere! The quickest move for me this month was my dash into Lake Superior. Well, actually, the dash out was more like lightning speed.
Visit Cook County is all about "getting our MOVE on". One of the two most significant moves occurred mid-month when we joined forces with our Info Center team and moved them to the new office building. A four month renovation project was completed and our new location promises to be more visible from Highway 61 and more spacious for our visitors.
While most of the crew stayed home and coordinated our Moose Madness Festival, a few of us hit the highway and headed south. Jim Vick, Kjersti Vick and I traveled to the Mall of America for the Minnesota Ski and Snowboard Expo. It was heartwarming and satisfying to hear from so many people regarding their love of our area. They truly call Lutsen Mountains home. Kjersti hit the road again the next week and attended the Windy City Ski Show www.windycityskiandsnowboardshow.com in Champlain (Chicago) Illinois. She is young and can do these back to back weekends which are extremely fun but very exhausting.
At the end of the month, the administrative team bid farewell to the Mayhew Building and MOVED to the heart of downtown. Visit Cook County and the Information Center are all part of one big team located at 116 W. Highway 61 (the old Gunflint Realty Building). I figure if I describe our location as the "old Gunflint Realty" AND NOT "right next to the Dairy Queen", I might forget that a DQ Blizzard is literally 20 feet away.
Please make sure to mark your calendars for:
Visit Cook County – Open House
Wednesday, December 10th
3:00 to 5:00pm
Kjersti, Anna and I will be packing our bags and taking Cook County to the metro once again. You'll find us wearing our moose horns and talking up a storm at the Midwest Mountaineering Outdoor Adventure Expo www.midwestmtn.com on November 21, 22, and 23. If you are visiting Minneapolis, please stop by and see us. We will be joined by many area businesses who have found this show to be an opportunity not to be missed.
Visit Cook County will also be a part of (for the first time ever) the Arrowhead Ice Fishing and Winter Show in Duluth on December 12, 13, and 14 shamrockprod.com/exhibitor/ice/iceehome.aspx . Just the name of this the show was screaming to me "you need to be here"!
In other exciting news, Lutsen Mountains opened for the 2014-15 season on Saturday. It was a beautiful sunny weekend with great man made snow. Open weekends until December, you can now get your move on down the slopes!
And last but not least, the coolest thing ever – our winter video will be part of pre-viewing in select theatres across the metro during the holiday season. The 15 second winter video clip will hit 57 screens more than 12,000 times from November 14 through January 8th. You will find us at the following theaters:
- Showplace ICON at the West End – Minneapolis
- Mall of America – Minneapolis
- Rosedale 14, St. Paul
- Eagan 16, Eagan
The post Kratt Chat: Get your MOVE ON! appeared first on Cook County Minnesota.
Dual Fuel Rate Interruption Today: November 17th
A Dual Fuel Rate Interruption will happen today, November 17, 2014 starting at 5:30pm until 8:30pm. You can check out load control schedules at http://lmguide.grenergy.com
It's Beginning to Feel Alot Like Winter
Temperatures have dipped down into the single digits and the wind has been blowing fierce. It feels more like January outside than November. The good news is after a few days of bitter cold the weekend forecast calls for temperatures in the 30′s again. I think I had better get all of my outside chores done this weekend because who knows when we may see this warm of temperatures again. If this winter is anything like last year it will be quite some time.
Quit Plastic and Think Your Safe From BPA?
There have been many reports of the dangers of bisphenol A (BPA), a chemical found in plastic food and beverage containers that can potentially leach into the foods they are stored, especially when microwaved. While there is debate over the ingredient, ever since I first heard of the potential danger, I will only buy containers with the "BPA-free" label hoping that it means it is safe and I NEVER microwave food in plastic. I will heat it on a paper or glass plate or eat it cold.
What I didn't know is canned foods is one of the biggest sources of BPA Americans ingest today. Yes, canned foods…like metal cans. According to the Good Housekeeping website:
The insides of food cans are often lined with an epoxy resin that keeps corroding metal away from the food. But bisphenol A in that resin can migrate into the foods; in fact, it's the major source of our exposure to the chemical, says the government's National Toxicology Program. While the FDA has issued reassuring statements about the risk, other experts aren't so convinced. In 2007, the nonprofit Environmental Working Group found BPA in more than half of the 97 food cans it tested, with the highest levels coming from chicken soup, infant formula, and ravioli. Just one to three servings of those foods with those concentrations could expose a woman or a child to BPA at levels that cause serious adverse effects in animal tests, the group concluded.
Though you may see "BPA-free" on some canned goods, food manufacturers are not required to list the chemical on labels, so you have no way of knowing whether it's present.
The scariest part of this report is the statement it's in the cans of infant formula and if you read the rest of the article, children have the highest levels in their bodies. How to limit exposure? Just like how we SHOULD eat:
- Limit processed, packaged and canned foods.
- Buy broths in boxed containers instead of canned or plastic.
- Have the bulk of your diet consist of fresh one-ingredient foods
- Use BPA-free baby bottles and sippy cups
EXTRA SPECIAL CAUTION: Plastic water bottles left in cars in the heat can be the worst culprits. The bottles usually are NOT BPA-free and when they are left in the hot car in the sun, it can be a bad combination.


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A transformer overheated near Zov's restaurant, causing a small fire on the roof, officials said.
TUSTIN – A small fire broke out on the roof of Zov's Bistro on Tuesday afternoon in the Enderle Center in Tustin.
Zov's Bistro employees were able to extinguish the fire at the one-story restaurant before the Orange County Fire Authority arrived, officials said.
The fire was caused by a blown transformer that overheated, said OCFA spokesman Marc Stone. People at the center heard three popping sounds when the transformer malfunctioned around 4 p.m. Tuesday, Stone said. No one was injured.
The restaurant at 17440 17th St. in Tustin, at 17th and Yorba streets, was only closed for one evening and reopened the morning after the fire.
People were evacuated from nearby businesses, including a hair salon.
Power was out for 1,474 Southern California Edison customers in Tustin and Santa Ana starting at 4:03 p.m., said spokeswoman Vanessa McGrady. Power has been restored to 409 of those customers, she said.
Edison representatives are investigating the incident, she said.
The outage are is bounded by Santa Clara Avenue, Vanderlip Avenue, Newport Avenue and the 55 freeway, McGrady said.
Contact the writer: 714-796-7949 or email@example.com
Comments are encouraged, but you must follow our User Agreement
Keep it civil and stay on topic. No profanity, vulgarity, racial slurs or personal attacks. People who harass others or joke about tragedies will be blocked. By posting your comment, you agree to allow Orange County Register Communications, Inc. the right to republish your name and comment in additional Register publications without any notification or payment.


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Tag: upgradeable
iMac 24-inch surprise: graphics card is upgradeable?
MacsimumNews broke down a MacGeneration post (a French publication) revealing that the new 24-inch iMac Apple introduced this week could quite possibly be the first iMac with a truly upgradeable graphics card. Thanks to a new Mobile PCI Express Module (MXM - originally designed for high-end...
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The good old days — if they even ever existed — are gone, and.Andy VanPutte thinks volatility in the resin market is here to stay and needs to be managed with a strategy just like sales, purchasing and manufacturing activities
This in-depth report examines the Brazilian plastics industry from a historical and geographical context. Our analysts provide insight on economic trends and forecasts, growing manufacturing sectors that utilize plastics, private investment opportunities, market environment challenges, and innovations in R&D.
Data tables and charts on producer prices, trade, plastics production and end market indicators is also included.
This report is a review and analysis of the North American Plastics Recycling Industry, including key trends and statistics based on 2013 performance. We examine market environment factors, regulatory issues, industry challenges, key drivers and emerging trends in post-consumer and post-industrial recycling.Learn more
This special package contains our 132-page 2014 Market Report on the Injection Molding segment and our exclusive 2014 RANKINGS database of 500+ Injection Molders for a discounted package price.Learn more
January 14, 2015 - January 14, 2015Plastics in Automotive
February 4, 2015 - February 6, 2015Plastics News Executive Forum 2015
June 2, 2015 - June 3, 2015Plastics Financial Summit - Chicago 2015
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October 27, 2015 - October 29, 2015Plastics Financial Summit - New York - 2015More Events


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[Each week, SOHH asks two entertainment personalities to name their Top 5 rappers of all-time. To make things tricky, we've created a "Hall of Fame" of emcees (see right) who are universally respected and therefore may not be mentioned. After Driicky Graham dished out his five favorites, producer Lee Bannon brings out his top spitters.]
Kanye West. Kanye is definitely on the same level as Tupac, Jay-Z and Biggie. I know this may sound blasphemous but I say this because of the social aspect. Pac was controversial and had the whole Black Panthers thing, Kanye's the same way with saying George Bush doesn't like black people. He had his moment in the little political spectrum and being controversial. On top of that, he's selling, his hip-hop and he's pop. That's very hard to do in hip-hop.
Wu-Tang Clan. I'd put the whole RZA and Wu-Tang in there. First of all, even though they were wilding out and acting crazy back then, they had the whold discipline with the Five Percenters impressed me. That kind of set the tone for hip-hop with "Word" and "What up, G?" They made people so into lingo that they don't even know what they're saying.
Cypress Hill. Cypress Hill is dope. DJ Muggs is one of the best producers out there. I'd say Cypress Hill is on that list.
King-Tee. I feel like Biggie bit him. Go on YouTube and listen to "Down A** Loc" by King-Tee. I'm telling you, he's on my Top 5. That's for sure. This is of all time.
Evidence. I'd put Evidence from Dilated Peoples on there. He might not even say that much, but he's a true emcee. He's like Tim Duncan because he's so fundamental.


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So true. I always say I never believed in love at first sight until the second they put him in my arms (not that I didn't love him when I carried him, but you know, that whole post-push hormonal surge and all). :)
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14th January 2008
Gay gamers experience Second Life
3:40 PM — Video games may come in many shapes and sizes, but one thing tends to stay the same from game to game: They all give the people playing them the opportunity to step into someone else's shoes.As thrilling as that sounds in theory, in practice it usually forces gamers to take control of characters that look little like them and move them through storylines over which they have little control.A few fairly recent releases have added some breathing room to that often claustrophobic aspect of video gaming.
11th January 2008
Website records life and times of Orton 1
2:55 PM — A website dedicated to the life and times of gay playwright Joe Orton has been launched.Leicester City Council joined forces with the University of Leicester and Islington Council to create the site, which has the endorsement of the Orton Estate.Despite his professional career lasting a mere three years, Joe Orton is still remembered as one of the most talented and outrageous playwrights of the 20th century.
Comment: L Word highlights US military's gay ban 2
2:39 PM — Actress Rose Rollins is speaking out about her The L Word character Tasha and the "Don't Ask, Don't Tell" storyline garnering national attention for her role.Playing a captain in the Army National Guard, Rollins' character is navigating the difficult choice many real LGB soldiers are facing in the US military — whether to stay in the closet or face being discharged and losing their careers.Although Tasha has developed a reputation as being the 'tough' girl on the show, her character is about far more than her exterior 'attitude'.
Seaside Pride will chase away the winter blues
1:30 PM — For those of you finding January a struggle, help is at hand from the seaside city of Brighton.Pride may seem like a distant memory, but fear not - Winter Pride kicks off on February 2nd, a festival of more than 70 events designed to cheer up even the most grumpy gay.The festival has something for everyone, from an 80's trans disco to a lesbian mud fight.
Extra performance for London's sold out gay panto
12:40 PM — A charity panto in aid of gay equality organisation Stonewall has proved so popular that an extra date has been added to cope with demand.On January 13 London Frontrunners will stage their A Christmas Carol at the Drill Hall in Chenies Street, with an extra evening performance at 7.15pm.The second performance will be in aid of the venue itself, the UK's premier gay arts venue which has recently been threatened with complete withdrawal of its Arts Council funding.
British Museum examines Rome's premier gay couple 2
12:10 PM — He is best-known in the UK for building a defensive wall as protection against the fierce Scots.However, back in Rome the Emperor Hadrian was noteworthy for taking his gay lover as a consort, a new exhibition about his life reveals. Hadrian: Empire and Conflict opens at the British Museum later this year. Publius Aelius Traianus Hadrianus, to give him his full name, was made emperor in AD117, when the Roman Empire was at its prime.
QBoy meets hip hop heroes
11:50 AM — Gay rap sensation QBoy fulfilled one of his lifelong dreams recently - meeting his musical idols Salt-N-Pepa.His interview with the queens of hip hop is part of a documentary for BBC digital network 1Xtra.The documentary about the return of Salt-N-Pepa by Made In Manchester productions has been co-produced by QBoy. This is the rapper's first radio production credit.
Pink Singers bring Continental show to London
2:15 AM — After two concerts in Paris, the Pink Singers are bringing Amour and more to London.Equivox, the vibrant Parisian lesbian and gay choir, will be the special guests of the performance which includes various love songs inspired in the city of Paris.The lesbian and gay community choir will be putting on the show on January 19th at Duke's Hall, Royal Academy of Music at Marylebone Road.
10th January 2008
Documentary uncovers the double lives of China's gay men
4:50 PM — Oscar-winning documentary maker Ruby Yang is to direct a film about homosexuality and the pressures created by China's one-child policy.China is known for its strong censorship, especially on sensitive issues. "There's a lot of pressure to produce an heir," Ms Yang told Reuters ."Many gay men are married and live a double life. They lie to their parents, lie to their wives."
Pride London parade to take place in July 4
12:55 PM — This year's Pride London parade and rally are set to be the biggest ever say organisers.The parade will take place in central London on Saturday July 5th."Following the enormous success of the Pride events in June 2007, and all the feedback we received from people who took part, our aim is to create an even bigger and better event for 2008," said Paul Birrell, Chair of Pride London.
World's first trans MP to be subject of biopic
12:40 PM — Two Australian-based film-makers have won the right to make a film about the life of Georgina Beyer, the world's first transsexual MP.Ms Beyer, who retired from politics last year, is co-operating with the producers of the film, which is said to have a sizeable budget."I'm not going to be one of those people that wants to be there every inch of the way and having some control over casting of course," Ms Beyer told 3 News.
8th January 2008
Documentary explores lesbian beauty 2
4:40 PM — A TV programme in which a bisexual woman goes on a mission to see if lesbians view the female body the same way as heterosexual men has been showing this week.Current TV is showing Lesbian Beauty as part of a week-long season it is currently hosting named Skin Deep, which is airing until January 12th.In a bid to go beyond the usual lesbian beauty stereotypes of 'butch' or 'lipstick lesbians,' Tat Grey visited the Miss Gay UK pageant, met the editor of Diva magazine and hit the lesbian clubs and bars on the street of Soho.
Playing gay characters is not 'brave', says Fry 2
11:40 AM — Gay actor Stephen Fry has said he is not impressed with straight actors who play gay characters.In a Radio Times interview, the QI host expressed frustration at how straight actors was seen as 'brave' for taking on a gay role.He said a gay man would never be considered 'brave' if he played an intimate scene with a woman.Fry's latest role on the small screen is that of solicitor PeterKingdom, in the ITV series Kingdom who is single and straight.
7th January 2008
Onscreen lesbian kiss upsets Egyptian academics 1
4:10 PM — A lesbian sex scene in an Egyptian film has outraged religious scholars, who are telling people not to watch the 'sinful' movie.An Islamic Studies professor at Cairo University wants the Egyptian authorities to prosecute the director and both actresses involved in the scene, Ghada Abdel-Razeq and Sumaya Al-Khashab.Dr. Abdel-Sabour Shahin believes the film, Hina Maysara (Until Further Notice), promotes homosexuality and debauchery and destroys the morality in society.
Barrowman: closeted actors are "just sad" 6
12:37 PM — Torchwood leading man John Barrowman has criticised gay stars who refuse to come out of the closet.The openly gay actor said his sexuality did not influence the kind of roles you got offered as an actor and believes it is "just sad" that someone would deny their sexuality to the world."If it (being gay) has been a problem, no-one ever told me so. I know people who lie about being gay because they think it will affect their work chances."
Sex overshadows De Beauvoir's contribution to French society
11:33 AM — Academics fear novelist and feminist icon Simone de Beauvoir's sex life may overshadow the celebration of her birth in France this week.Critics are concerned with the French press condemning her sex life instead of highlighting her contribution to modern thought.The author and philosopher shocked the Parisian society of the early 20th Century with her threesomes and affairs with women.
4th January 2008
Gay Tory to star in TV comedy
5:04 PM — A former Big Brother contestant who was once a Conservative parliamentary candidate may star in a remake of a controversial 1970s television programme.Derek Laud, who also worked as a speechwriter for several leading Tories and as a lobbyist at Westminster, is an unusual figure in the party, a black, camp and openly gay man.He was a contestant in the sixth series of reality show Big Brother, which was eventually won by Anthony Hutton.
Xena stars top lesbian lust list 3
4:45 PM — Lucy Lawless, the actress who played Xena: Warrior Princess, has topped the LesbiaNation Top Ten Women We Love of 2007.The popular lesbian website lists "beautiful and talented women of all persuasions, artists, musicians, athletes, filmmakers, movie stars and television celebrities," but all of the top ten as voted for by their readers are TV stars.In second place was Renee O'Connor, last year's winner, who also starred in Xena as Gabrielle.
Rosie O'Donnell is most annoying celebrity
4:40 PM — Comedian, talk show mainstay and LGBT rights activist Rosie O'Donnell has hit back after being voted 2007's most annoying celebrity.The readers of Parade magazine in the US chose the 45-year-old, who took the title with 44% of the vote.She beat off still competition from other hated celebs Heather Mills-McCartney, rightwing polemicist Ann Coulter and gossip blogger Perez Hilton.
Elton's concert could help gays says Tatchell 3
1:32 PM — Sir Elton John has sparked controversy by setting a concert date in Abu Dhabi later this month.Homosexuality is punishable with imprisonment of up to 14 years in the country and there is general discrimination towards homosexuals in the United Arab Emirates.Peter Tatchell, gay human rights campaigner from OutRage!, said:"In early 2006, the United Arab Emirates imposed six years jail on 11 gay men arrested at a private party."


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Today's video talked about various self-help and personal development tools, and essentially was a pep talk for doing what it takes to maintain your attitude of success. Success, Steve says, is simple, but not easy. Duh! Make a decision. And develop the mental toughness to follow through on your promises to yourself.
Well, that's not new news to most of us Sparkers, is it? I sometimes have a hard time with his terminology. I am not particularly crazy about the term "mental toughness", you know? I respond better to a concept of kindness to myself. Yes, there are times to tough it out, but there are also times to bind up broken feelings and hug oneself.
Still, over all, I believe in any method to keep one going... try it, and if it works, fine, if it doesn't, let it go.
1. What are your beliefs about self-help and personal development?
I'm a bit of a self-help junkie. Love the stuff. I will use *anything* that keeps me motivated.
2. Are you mentally tough enough to keep your word by sticking to your diet?
No. I'm not. Not 100% of the time, not perfectly. But consistently. Over the long term. I'm working on it.
3. What are three key beliefs about weight loss and fitness you'd like to change or upgrade?
1. That I have to be perfect to be worth it.
2. That I can't keep it off long term.
Not sure I can come up with a third...
Life is good... Spark on!
Today's video focus was on being prepared for the tough times with strategies for success. Wanting something isn't enough... there is legwork in this process.
1. What foods (that are 'legal') on your diet will satisfy you or at least make it easier to handle dangerous emotions like boredom, frustration, stress and discouragement?
Volume and warmth for trapped in the house snow days... soup. Taking my own snacks when food days happen at work. "Legal" single serving treats for weekend days... but be careful with portion sizes.
2. Do you fully understand how breaking your new habits even one time can begin to unravel your new habits?
Yes. Been there. Done that. Know the pattern.
3. What is your script for handling pressure to eat at family functions and parties?
Actually, I don't get a lot of this any more, as all of us are watching our health. But what has worked: "I've worked too hard to get here to undermine it now by ____." Or "I have had too many of these recently, I'll pass today."
It was an absolutely gorgeous day for a run/walk yesterday. As I drove toward the starting venue, I observed several joggers out and about already between 7 and 8 a.m.
Most of the runners who commented on the weather were complaining of "the heat", and it was warm for March 31st, for sure. Consider last year we walked this in snow.
I met up with HOT4FITNESS at the start of the race, and we walked together the first loop around the building and to the beginning of the gravel trail that constitutes the largest portion of the race. That's almost the first mile, and is the first water stop. After the water, I took off jogging. I figured easy jog for a mile, then maybe walk/jog alternate miles. Got to the 2 mile marker, still felt good, and jogged on past the 3 mile marker before dropping to walk. Did not walk for very long in any of my later rotations, did jog slower sometimes, faster other times.
My legs started complaining after the halfway point, and I kept varying my pace in the hopes of finding a comfortable stride. But walking was harder than jogging by then, so a slow jog was pretty much in order for the remainder of the race. I shaved more than 20 minutes off my walking time from last year.
Things that happened, of note: you know that nightmare of driving and having a deer jump out in front of you? Well! A few of us discovered it can happen while running/walking/jogging, too. Right out of the bushes, maybe five or six feet in front of me. Thought it was a large dog at first, but NO... a very frightened deer. She (I assume it was a doe) dashed from the woods on one side of the path into the clearing on the other side and kept right on running... as did we.
Back at the start/finish line, I walked into the building in search of "the necessary", and overheard a man approaching a security guard, looking for the EMTs to help another guy who was in the men's room. Several minutes later I observed the ailing gent carried out on a stretcher. Let me remind you... road racing is a dangerous activity... it can uncover health issues. Prepare. Train. And don't be fooled by the adrenaline rush that happens at such events.
A smart runner I met? A young woman who knows she has a rapid heart rate, had her doctor's permission to run, and monitored her heart rate throughout the ten miles, dropping back to a walk until the heart rate went down, and then adjusted her pace up again once it got to a safe level.
She was among several folks I ended up playing tag with, thoughout the ten miles. During my walk intervals they would jog on by. During my jog intervals, I would catch up. In the end, I finished with a personal best for 10 miles, 1:47:28. And I have a plan for the next week... swim today, strength at least one day, get back to mileage building walk/jogs toward the latter half of the week.
It was a blast, people. Be careful, but don't let that stop you from doing what you dream. Do it smart, but do it! Spark on.
Part of this morning's video was focussed on the question "what are you willing to do to achieve your goal". There is only one correct answer: "Whatever it takes". I've had "I'll do whatever it takes..." as part of my Spark page since the beginning. While I've said it, there have been times when I've forgotten that I meant it.
The opposite of "whatever it takes" is an attitude of "I'll try" as opposed to "I'll do".
1. How has negotiating the price of success hurt you in the past?
I'm trying to think whether I've ever done this. I must have? But I've been at the "whatever it takes" stage Steve talks about for a while now, and am recommitting to it. I think I have done well in the past but then NOT committed to maintenance, leading to the regains.
* I have in the past come to the conclusion that I wasn't willing to do what it takes and that brought me to the giving up, slip-sliding away place. I'm not sure if that qualifies as "negotiating the price of success", or walking away from the other fella's best offer.
2. Have you really committed to doing 'whatever it takes' to achieve your weight loss goal?
Yes, ma'am, yes, sir. I am committed to the current goal, which is maintenance within a range.
3. What tools, tips, strategies and resources have helped you most in this course?
Not sure if I've heard anything particularly new. I've been down this road. Some things I was already doing. Some things I have discovered from past experience are counter productive for me, personally. I would say what's helped me most is the videos: having a guy talking at me that I can talk back to and evaluate his message for how much it might really apply. That, and the reminders to USE tools that work.
Now today I found myself agreeing with him! It goes in waves... talking back or cheering "Yes! That's what I've learned!"
Today it was about maintaining momentum and the importance of consistency / keeping our goals fresh. Because things *do* change.
1. On a scale of 1-7, 7 being best, how good is your attitude on a normal day?
"Normal" day - during the week? 7. On weekends, I drift down at times to a 5. It's easier to feel deprived on those non-work days... and it has to be guarded against. Extra pep talks in order!
2. How have you used momentum to help you succeed in the past?
Oh, this is huge: keeping one small promise to myself motivates me to keep the next one. It's a snowball of woo-hoo! On the other hand, momentum of beating up on oneself can really take me the other way. And taking that first mis-step can push me way down the other way. Better not to start. At work... bypassing the treats table feeds staying compliant all day long. Being compliant one day fuels the next day's compliance.
3. Why do you want to be fit?
Being fit gives me a quality of life I only dreamed of when I was fat. For me, nowadays, it really is all about feeling good and being healthy. It feels wonderful!


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"Washington DC's Metro System" Top 5 Page for this destination United States of America Transportation Tip by deecat
United States of America Transportation: 240 reviews and 240 photos
I agree with the reporter, Frank Clines who said, "The D.C. Metro is one of the wonders of the Western World. It's still as pristine now as it was when it opened over twenty years ago." As a visitor to Washington, I was amazed at the efficiency, reliablity, and safety (not to mention cleanliness) of this city's subway system...Of all the large cities that I have visited, it is, by far, the best.
Part of the reason it remains so clean is that the trains themselves are constructed from "graffiti-resistant material". Also, the organization itself is efficient; even the maps that they hand out are easy to follow. This subway is built deep underground because of Washington's swampy terrain. Thus, you have to ride long escalators to reach most Metro stops. But, what the heck, they are fun. If you have an opportunity, take a look up when on the Dupont Circle escalator. I'm sure that you will agree that it is really something.
One of the reasons that I was so surprised about the great Metro is because I had read that the city of Washington was notoriously bad with public services. They supposedly have poor snowplowing services as well as trash pick-up.
Note: Remember not to throw away your ticket. You will need it
I just wanted to include positive comments about this wonderful city.
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Book your room at United-21 Resort, Kodaikanal
Standard Room, 1 Double or 2 Single Beds, Valley ViewMax Occupancy: 4 guests (up to 3 children, 2 infants)
Deluxe RoomMax Occupancy: 3 guests (up to 2 children, 2 infants)
Honeymoon SuiteMax Occupancy: 2 guests
Family SuiteMax Occupancy: 4 guests (up to 3 children, 3 infants)
Standard Room, 1 Double or 2 Single BedsMax Occupancy: 4 guests (up to 3 children, 2 infants)
Kodaikanal hotel with a restaurant
Situated in Kodaikanal, this hotel is close to Kurinji Temple, Kurinji Temple Kodaikanal, and Bryant Park. Local attractions also include American University of India and Silver Cascade.
Hotel Features
In addition to a restaurant, United-21 Resort, Kodaikanal features laundry facilities. Other amenities include a business center and high-speed (wired) Internet access (surcharge).
Room Amenities
All guestrooms include high-speed (wired) Internet access (surcharge), minibars, and desks.Information missing or incorrect? Tell us!
United-21 Resort, Kodaikanal
Hotel Amenities
The hotel offers a restaurant. Wired high-speed Internet access is available for a surcharge. This 3-star property offers access to a business center.
- Restaurant
- Airport transportation (surcharge)
- Business center
- Wired (high-speed) Internet access - surcharge
- Laundry facilities
Family Friendly Amenities
- Laundry facilities
Available in all rooms: Wired high-speed Internet access (surcharge)
Available in some public areas: Wired (high-speed) Internet access - surcharge
Room Amenities
- Minibar
- Desk
- Room service
- Wired high-speed Internet access (surcharge)
Where to Eat
United-21 Resort, Kodaikanal has a restaurant on site.
Room service is available.
Hotel Policies
Check-in time starts at noon
Special check-in instructions:
Check-out time is noon
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Christmas Eve (24 December) Gala Dinner per adult: INR 750
- New Year's Eve (31 December) Gala Dinner per adult: INR 750


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Make a home for wildlife
Image: John Markham
House sparrows, starlings, house martins and swifts depend on buildings for nest sites. The last two species are almost completely dependent on them. Roofs are also important habitats for roosting bats.
Opportunities for birds to share your house are greatest in older properties. Modern building techniques and renovation materials can prevent their access, unless you provide specific opportunities.
There are five steps for safeguarding existing nest sites or creating new ones in your roof:
If you're in the process of purchasing or building a new house or extension, ask either the developer or builder to fit internal nestboxes for swifts, house sparrows or starlings into the design of the building. You could also fit external nextboxes. More...
Considering renovations? You can help the birds that may be nesting in your roof by protecting existing nest sites. More...
Green roofs have been used extensively on the continent for some time and are now becoming more popular in the UK. Mosses and lichens will grow naturally on most roofs, but a green roof is intentionally designed to support vegetation. More...
The RSPB speaks out for birds and wildlife, tackling the problems that threaten our environment. We rely upon memberships and donations to fund our work. Nature is amazing - help us keep it that way. More...
Visit our Contact us section for telephone numbers, office addresses and more.
21 November 2014
Conservationists are thrilled that lapwings, birds which have been disappearing from the UK, have had a successful 2014 breeding season in grassland habitats managed by the RSPB.
13 November 2014
The RSPB is today urging Defra to publish the workable elements of the Hen Harrier Action Plan, which the Society believes could bring about the recovery of one of England's most beleaguered birds of prey.
10 November 2014
The Conference of the Parties of the Convention on Migratory Species (CMS) has agreed a set of guidelines to tackle causes of poisoning and ratified a groundbreaking Action Plan to save more than 400 bird species.
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The League (2009– )
Plot Summary
A group of friends who are in a grown men's fantasy football league. They battle between life and the computer in a funny semi scripted show.- Written by sammyziegelman
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Property and several stolen guns taken last month from a White Pigeon bait and tackle store were recovered by investigators from the St. Joseph County Sheriff's Department. Deputies were dispatched Saturday to a residence in the 67000 block of Blue School Road in Constantine Township regarding an unwanted subject. During the investigation, deputies located and seized items from a breaking-and-entering ... Read More »
St Joseph County
Marine Corps permanent meeting
The St. Joseph County Area Marine Corps League has a permanent meeting place and time. Following the group's first meeting as its own chapter last weekend, members agreed to meet at 6 p.m. the second Tuesday of the month at the FOP Hall, east of Centreville on M-86. Members had staged both an informational meeting and Saturday's inaugural meeting at ... Read More »
Fitz to seek third term
Victor Fitz announced Monday he will seek a third term as Cass County prosecutor. The 54-year-old Fitz was previously elected as prosecutor in 2004 and re-elected in 2008. Fitz was originally appointed to the position by Circuit Court Judge Michael Dodge in May 2003. A veteran law enforcement official, Fitz has served in the field of prosecution since 1983. He ... Read More »
McDonough to run again
St. Joseph County Prosecutor John McDonough announced last week he will be seeking re-election to another four-year term in November. The 32-year-old McDonough is in the fourth year of his initial four-year term after upsetting incumbent Doug Fisher in 2008. McDonough said representing the citizens of St. Joseph County has been an honor and he indicated he hopes to continue ... Read More »
Millage renewal to be on ballot
A millage renewal to support the St. Joseph County Commission on Aging is expected to appear on a countywide ballot later this year. The amount of the renewal, however, is being debated by the St. Joseph County Board of Commissioners. During Friday's executive committee meeting, which drew all seven commissioners, discussion stemmed from the three-quarters of a mill expiring this ... Read More »
Trailway master plan meeting
The first of what could well be a number of trailway master plan meetings in Sturgis took place last week. About 50 people attended the session, which centered on ideas and potential routes, corridors and connections for non-motorized traffic. Participants noted existing roadways – including Congress and West streets in Sturgis – along with abandoned railroad rights-of-way could be utilized ... Read More »