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In its recent third quarter reporting, the company posted a 7% decrease in user engagement and a slide in growth of monthly active users: growth increased 23%, but that was down from 24% posted in the second quarter of 2014 and down from 38% reported in the third quarter of 2013. Consequently, Twitter's stock price has fallen in recent weeks, and the S&P downgraded Twitter's debt to junk status, describing the company's risk as significant. So, how did it come to this? Where did Twitter go wrong, and, more importantly, what can it do to right the ship and recruit new users?
Jun 30, 2006
Thomson Scientific, a business of The Thomson Corporation, has announced a new enhancement to Thomson Pharma, a drug discovery and development information solution for professionals working at all stages of the drug development pipeline.
The new Thomson Pharma Generic Competition Module is a strategic tool for research-based pharmaceutical companies. The module provides critical, early intelligence, and independent analysis to help companies identify and assess signs of generic competition for brand products. The module is derived from the Vision CITM system, which provides Product Lifecycle Management teams with the analysis by which to forecast loss of product exclusivity, the ability to identify competition, and the potential effects of generic entry on their competitor's products. The module also gives pharmaceutical companies a tool for identifying and tracking early generics activity, and researching potential competitors.
(www.scientific.thomson.com; www.thomson.com)


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Blue Hill by Hand manufactures earrings, necklaces, rings, bracelets, bubble wands and ornaments. All of our products are hand-made in the United States by local artisans supporting economically sustainable lives. Reduce. Reuse. Recycle. Respect. What a simple (and beautiful) small step in creating a better world.
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Brass leaf charm. Antique-brass earwire.Ā
Patinated brass charm with glass bead. Color may vary. Brass kidney wire.Length: 2 1/4"
Brass charm, brass filigree bead, faceted crystal rondelle bead.ĀBrass earwire.Length: 2 1/4"
S-hook and mesh ball, faceted crystal rondelle beads and brass spacer beads. Brass earwire. Currently available only in silver mesh.Length: 2 1/2"
Matte-black chain with gold-plated rings. Gold-filled earwire.Length: 2 1/2"
Antiqued copper hoop and freshwater coin pearl. Copper earwire.Length: 1 1/4"
Sterling wire shaped into a heart. Length: 3/4"
Silver-plated orchid charm holds a czech crystal rondelle. Colors vary. Sterling earwire.Length: 1"
Why Knot$22.00
On The Fringe$28.00
Abstract Bubble$32.00
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subset: commoncrawl


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Winnipeg Free Press - PRINT EDITION
A lesson in kindness from story of cruelty
It's a "sad story," or so the woman who experienced it warned me, as I'm warning you. But, in a way, it's also a story of hope. One that is reminiscent of Stand By Me, the coming-of-age film where four 12-year-old boys discover the body of another kid beside a river. Except this story is about a group of younger eight- and nine-year-old girls whose own right of passage seems to have happened long before last weekend, when they found a different kind of body by a different river.
-- -- --
The longest Winnipeg winter in living memory seemed to finally be over Saturday when, enticed by the spring-like weather, Louise Thiessen ventured out for a walk in St. John's Park.
Which is where the middle-aged woman was startled to see a nine-year-old girl standing alone by the edge of the swollen and racing Red River.
"I called out to her that she was in danger and to step away," Louise would tell me later, "and she said she'd found a puppy in a box floating by the river."
The little girl was using a stick to keep the box from being swept away.
Louise ran to her side and pulled the box to shore.
The puppy, Louise quickly determined, was dead.
"It had been strangled with a shoelace."
The little girl told Louise she had seen two women in the bushes wearing hoodies place the box in the river and when it stayed close to the river's edge, the curious lone little girl had fished it closer. As it turned out, though, the little girl wasn't alone.
Suddenly, there were six girls gathered around Louise, all about the same age, all aboriginal.
"And I had to tell them all the pup was dead."
The girls didn't want to believe it.
"They kept asking, 'Are you sure the puppy isn't just sleeping?' "
Louise knew they couldn't just leave it there, so they all began walking back to her house.
"Me carrying the box and them chattering away like kids do at that age, saying how much they love animals, and about their pets, and how some of them had come to sad ends."
They all told Louise they wanted to work at the humane society when they grow up, looking after puppies like the one in the box they had hoped was just sleeping.
Then, seemingly out of nowhere, the girls began talking about another little victim of a cruel death.
Phoenix Sinclair.
Louise was distressed they knew so much so young. And how they talked so matter-of-factly and in such graphic detail about the cruelty inflicted on Phoenix by the people who were supposed to love and care for her.
"I guess that's what they see," Louise reflected. "That's a sad thing in itself, that they have come to expect this sort of thing."
The saddest part, Louise said, is these children may grow up to be messed up, and we just shake our heads.
"These kids think most adults are mean. I just think we need to show them kindness instead of coldness."
So it was that Louise and the girls ended up standing in front of her home, where they placed evergreen branches over the puppy's cardboard coffin and set it near the curb for Animal Services to pick up.
"We talked about heaven, and I told them that I believe animals go to heaven because they're innocent and God loves them even more than we do."
The girls agreed and gave him a name.
Happy Golden.
"Because they decided he's happy in heaven even though people were cruel to him down here."
Louise told them their hearts were so sweet and more caring than many adults, and that they could come visit her anytime. She wept as she spoke. The girls didn't. None of the children had cried, from the time they found Happy Golden beside the river until the time they left him beside the road.
I asked Louise about that.
You cried, but the children didn't?
"I think it was more for them," she said, "than the puppy."
-- -- --
It wasn't just a group of children coming upon a body that made me think of Stand By Me.
It was the fact that, in their own way, the six little girls stood by the innocent puppy at the end of its short sad life, the way they stand by each other. But mostly the story of the little girls and the puppy in the box reminded me of how many more adult role models like Louise Thiessen these children need in their lives.
To stand by them.
Republished from the Winnipeg Free Press print edition May 3, 2013 B1
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Ok guys, I need help (!) I'm new to Bestheda and their games. I've just started Fallout 3 and have become 'Overemcumbered' What is the solution/how can I overcome this strength problem with my character?
#3991463, By martinthemonkey Fallout 3 concerns...
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Bend loses tax fight
|| Print |
|High Five
|Friday, October 02, 2009
A special tax on downtown property owners was at the center of the city of Bend's three-year dispute.
Read the full story at The Bulletin.
{biztweet}Bend Oregon property tax{/biztweet}
|A Complex Portrait: Immigration, Jobs and the Economy
|Revenge Forestry
|Woman of Steel
|The Bookseller
|Kill the Meeting
|Political Clout
|Mergers lucrative for departing CEOs, but not necessarily shareholders
|Senators ask, but get no real answers regarding safety from air bag executives
|Senate investigation says Wall Street misused commodities businesses
|Amazon says its cloud services will run on renewable energy
|Home building falls in October due to apartment sector
|Dollar hits highest point against Yen since 2007
|Investors wonder if OPEC cutback is imminent
Is your business ready to join us in the call for action? This opening panel includes Oregon businesses who will discuss why they signed the Oregon Climate Declaration, the investments they are making to reduce carbon emissions, and how their actions are affecting their companies.
Get ready for two days of special events produced with the EPA, Portland Timbers and ISOS before and after the GoGreen Conference on October 16.
Plenty of employers seem "dazed and confused" after the recent vote to legalize marijuana. In light of Measure 91 passing, what are some issues for private-sector Oregon employers to consider?
Rotary's Oregon Ethics in Business aims to raise consciousness about business ethics by honoring exceptional companies.
Barran Liebman's annual employment law seminar is an industry classic.
Is my drug-free workplace policy up in smoke?
More than 400 "Change Makers" will gather to invest in a socially sustainable community.
Sussman Shank LLP is pleased to announce that Dallas G. Thomsen and Victor J. Roehm have become partners of the firm.


text:
Tag archives for prevention
Previous research has documented a link between downturns in the economy and suicide among adults. But how do those downturns ripple throughout families and communities, and in particular, how do massive job losses affect the mental health of teens? A new study has found that, sadly, many teens are not immune to the stress of a struggling economy.
Twenty-three years and millions served: CDC's National Breast and Cervical Cancer Early Detection Program
Next time someone asks you what exactly public health does, repeat this number: 4.3 million. That's the number of women — mothers, sisters, wives, aunts, grandmothers, daughters and friends — who might have otherwise gone without timely breast and cervical cancer screenings if it weren't for public health and its commitment to prevention.
Today, the Centers for Disease Control and Prevention released new data on heat deaths among U.S. workers, underscoring the often-tragic consequences that result when employers fail to take relatively simple and low-cost preventive actions.
Next time you pass a tree, you might want to give it a second thought. Maybe even a hug. One day, that tree might just help save your life.
McDonald's ruling could be a major turning point for the fast food worker movement; federal commission clarifies rules for pregnant workers; miners with black lung may have been wrongly denied benefits; and a new OSHA whistleblower partnership is launched to support commercial carrier workers.
Studies: Students initially complained about healthier school food, but now it's like totally not a big deal
Nearly two years ago, American schoolchildren began sitting down to healthier school lunches, thanks to new federal nutrition guidelines. Media reports of the nutrition upgrade weren't terribly encouraging, with stories of unhappy kids, unhappy parents and politicians who think addressing childhood obesity is an example of the "nanny state." However, recent research has found what most parents probably already know: Kids are pretty adaptable — they just need some time.
Vaccine safety is one of those topics that has become so tragically mired in misinformation and myth that there can never be enough supporting evidence. So, here's some more.
Building safe ways for children to bike and walk to school is more than just a way of encouraging kids to go outside and get active. According to a new study, it's also an investment that reaps millions of dollars in societal gains. In other words, smart walking and biking infrastructures for kids make good economic sense.
Public health ROI: Study finds investing in lead poisoning prevention could reap millions in benefits
Childhood lead poisoning is one of those health risks that everyone has likely heard about, but many probably think it's a problem of the past. However, a recent study reminds us that in just one state — Michigan — the effects of childhood lead poisoning cost about $330 million every year. And that's a conservative estimate.


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New York Giants: Why James Brewer should be nervous
James Brewer OTAs are in their final week, mandatory mini camp will begin shortly after, training camp will commence July 21, and so it's safe to say that the New York Giants offseason training is moving along and showing great results. The rookies are settling in and Eli Manning has said that he believes he is at 100 percent and can get back to playing at his fullest potential...
Via isportsweb.com
June 11, 2014 | Discuss
Giants O-Line on move, Boothe to C, Brewer LG
The New York Giants' offensive line is once again doing the injury shuffle. For the sixth time in 12 games, an injury will force the Giants to field a new starting combination on the line in front of quarterback Eli Manning. The latest lineman to go down was third-year center Jim Cordle. He injured his left knee in Sunday's loss to Dallas and was placed on injured reserve...
Via AP on Fox
November 27, 2013 | Discuss
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Truck Series champion Matt Crafton will be on standby at Las Vegas Motor Speedway this weekend for Paul Menard, who awaits the birth of his first child.
Jennifer Menard remained in North Carolina while Menard made the trip to Las Vegas for Sunday's Sprint Cup race.
MORE: Las Vegas schedule | Harvick leads Vegas test | Biffle, Roush teams slow | Earnhardt fans
Crafton will be on standby for all practice sessions and the race. Crafton won the Truck Series championship last season, and although he has 317 career starts over 15 years, he has never raced in the Sprint Cup Series. NASCAR wanted to observe Crafton in the No. 27 Chevrolet on Thursday to approve him as the standby driver.
Crafton and Menard have been close friends since 2001, and he said he's honored Menard has the confidence in him to step in if needed.
PHOTOS: NASCAR families
Menard enters the race 24th in the standings after finishes of 32nd at Daytona and 23rd at Phoenix.


text:
I didn't see this in the Known Issues post, so I thought it best to put it here.
I logged in on my phone, accepted some invalid SSL certs (probably not the brightest thing I've ever done), and got an email asking me to verify the account. I clicked the link, and was taken to the monthly/yearly subscription page. I'm already a paid subscriber, so that's why this post exists.
I'm on my Android smartphone using Chrome. Not that it should make a difference anymore, but just another point of data to add.


text:
From a young age, our parents teach us to be joiners.
When I had scarcely learned to walk, my mom enrolled me in a group ice skating class—complete with ice show participation (I recall wearing a sequined frog costume). Along with that, came piano lessons, art classes, swimming classes, summer camp, carpool groups and more. Before I graduated from elementary school, I knew it was time to leave my mark on society and run for student council. I blew the elementary school gymnasium away with my candidate speech for secretary.
That desire to be grouped continues through our school years, but I think it's sometimes forgotten after we graduate college—a period in our lives when we are most disenfranchised and posse-less. We remember to join a gym and to network to find a job. When it comes to other social experiences, sometimes we're on our own unless we seek out new opportunities. That said, I think JUF really steps up when it comes to providing social outlets for people in their 20s and 30s.
My first couple years after college were sometimes a social struggle. After graduating from the University of Wisconsin, many of my friends scattered all over the country. Thankfully, when I returned home to Chicago, I reconnected with childhood friends. However, some childhood friends also had moved or our relationships had changed from time apart. Those of us who were around were busy trying to figure out our careers via internships and first jobs. We also found ourselves dumbfounded by a Chicago bar scene where everyone didn't already "know our name."
College is perhaps the most socially enriching environment one can have, particularly if you attend a university that nearly engulfs the city in which it resides. In college, I was surrounded by thousands of people my own age, engaging in local activities geared toward the majority population. During my senior year at college, most of my closest friends lived within a 3 block radius of me. We could have performed the old movie cliché with the cans and string from our windows (quaint, yet unnecessary in a cell phone era).
After a few years of life as "an adult" and forging new and different friendship groups, I've become more of a joiner. Ironically, the joining came after the friends. I'm of the belief that you can never have enough new people in your life. I also am a big fan of introducing friends to each other, because then I can hang out with people from various facets of my life at one time and not worry about them having nothing to say to each other.
About a year ago, I found myself reunited with a childhood friend who'd moved back to the city after nearly a decade away. This friend reunion put me in such a giddy state, that I wanted to spread the love. Around that same time, I decided to form a book club and include reunited friends, work friends, old friends and all of their friends. To say the group was a "mish-mosh" is an understatement.
Our book club is preparing to celebrate its one-year anniversary this month. The group is larger than ever, and its members are very dedicated to reading and to each other. Book clubs are often stereotyped for consisting of chatty, catty ladies who discuss the book for five minutes a meeting and then drink wine and gossip. My group legitimately breaks down each book in heated discussion (while stuffing our faces with potluck food). In fact, we've had two authors join our discussions, including Oy!Chicago's Rachel Bertsche.
I love the group for its diversity, for the ladies' outspokenness and for their tolerance. It has become an unexpected community of intelligent women I never knew I needed and wanted in my post-college life. Many of the members have found the book club has also re-ignited their passion for reading. Not to mention, friendships forged in the club have led to other social outings and even joining workout classes together.
My advice to newbies in the city and those who are mulling through those early 20s is to continue to put yourself out there and meet new people. Start a group or club based on an interest, and invite people you might not know well to join.
Groucho Marx once said, "I don't want to belong to any club that will accept me as a member."
However, I recommend surrounding yourself with unlikely company. You'll be amazed at who you meet along the way.
Sheraton Chicago, 301 East North Water St.
Saturday, December 13 | 8:15 p.m.
Featuring an evening of standup comedy with SETH MEYERS
Emmy award winner and host of Late Night with Seth Meyers
8:15 PM – Doors Open, wine, beer & concession snacks at your table9:00 PM – Program Begins
AFTER PARTY immediately following Seth MeyersBigger and Better This Year!Head downstairs for two hours of open bar, late night food and DJ
Big Event is YLD's premier fundraiser. Your attendance requires a gift to the 2015 JUF Annual Campaign and reflects your commitment to building a stronger Jewish community in Chicago, Israel and throughout the world.
Learn more and register now at www.yldchicago.org/bigevent
Castle Chicago, 632 N. Dearborn St.Wednesday, December 24 | 8 p.m.
The Official Matzo Bash 2014, Chicago's ONLY Christmas Eve Gala! Last year over 1,500 people attended! This is THE party that everyone will be at!
It's Christmas Eve, what else are you going to do?
Your ticket will include:- 8-10 p.m. Gourmet Appetizer Buffet & Drinks*- Discounts on VIP tables reservations- Covered heated check in area- ONE-STOP-SHOP open until 4 a.m. with a full restaurant and 5-levels of schmoozing & dancing- Tickets are emailed to you when purchased with no shipping/handling fee's
Matzo Bash tickets are selling quickly! Get the Early Discount and buy your ticket now! Click here for $15 tickets!


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text: If you saw this movie you probably loved it and I can't blame you. You may have also noticed the soundtrack. I found a CD yesterday and listened through it. I have to say the CD is awesome. Two tracks stand out as way above the rest. "In Time" and " Walk Away" both strike me as being awesome rock tracks. But the many other tracks will have you doing air guitar and bobbing that head


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Wirathu rejects 'self-immolation' rumours
The nationalist monk rejects widespread rumours on social media that he vowed to carry out self-immolation as a protest if Burma fails to adopt proposed Race Protection Laws.
The nationalist monk rejects widespread rumours on social media that he vowed to carry out self-immolation as a protest if Burma fails to adopt proposed Race Protection Laws.
The English website of The Irrawaddy was brought down on Thursday by hackers, following the Burmese news group's coverage of nationalist monk Wirathu.
The divisive Burmese monk will attend a conference in Columbo, organised by Sri Lankan Buddhist nationalist group the Bodu Bala Sena.
Lead Story News Politics Suu Kyi Video
NLD's Win Tin meets nationalist monk Wirathu in Mandalay to discuss the NLD's aim to amend Article 59(f) of the constitution
President Thein Sein has defended the prominent anti-Muslim monk Wirathu and his controversial "969" movement, after Time Magazine described him as "the face of Buddhist terror"
Following the publication of the July issue of Time that features notorious nationalist monk Wirathu on the cover along with the headline: 'The Face of Buddhist terror", Burma's government says[...]
Burma's most notorious monk, Wirathu, has spoken out about Time magazine's July issue which features his photo and the headline: "The Face of Buddhist terror" on the cover.
Buddhist nationalists in Magwe division have become the latest to march in support of the controversial Interfaith Marriage Law.
Watch today's top stories with Angus Watson
Watch today's top stories with Angus Watson.
Watch today's top stories with Angus Watson.
Watch today's top stories with Angus Watson
Watch today's top stories with Angus Watson
Watch today's top stories with Angus Watson
Burma's nascent internet industry has seen rampant abuse by extremist groups spreading misinformation, inciting violence and circulating false reports and pictures.
Watch today's top stories with Angus Watson.
Watch today's top stories with Angus Watson.
The English version of The Irrawaddy, a popular Burmese news site, was brought down on Thursday by activists calling themselves the Blink Hacker Group. The hackers appeared to target The[...]
Communal Violence Lead Story Mandalay Division News
Mandalay regional government said it will imminently lift a curfew that was imposed in seven townships across the city at the beginning of July following deadly communal mob violence.
Communal Violence Lead Story Mandalay Division News women's issues
A young Muslim woman who claims she was raped by a court official has dispelled reports that her case is linked to recent riots in Mandalay.
Lead Story News religion Society Video
The All Burma Monks' Union say Buddhist monks at the scene of riots in Mandalay on Tuesday night had helped diffuse the situation, not enflame it.
Lead Story Mandalay Division News religion Society Video
Police officers are lining the streets of Mandalay after violence between Buddhists and Muslims broke out on Tuesday night.
Ethnic issues Lead Story News Politics women's issues
Ninety-seven civil society organisations, including several women's rights groups, spoke out on Tuesday against Burma's proposed Interfaith Marriage Act.
Analysis Contributor Lead Story
Proposed interfaith marriage laws reveal the link between ethnic sectarianism and gender inequality in Burma, writes Dr Nyo Tun.
Contributor Lead Story News Society
The term 'ethnocentric Buddhism' points to the notion that Buddhist identity is intrinsically linked to national identity, says scholar Dr Paul Fuller.
National League for Democracy veteran Win Tin, 84, remains unconsciousness in Rangoon General Hospital following an operation on his large intestine, fellow central executive committee member Win Myint confirms to DVB.
Ethnic issues Lead Story News Politics Rohingya
Arakanese Buddhists from all of the state's 17 townships have vowed to boycott Burma's upcoming census after the government ignored an ultimatum to omit the term "Rohingya" from data collection.
The Hawaii-based East-West Centre is hosting the fourth iteration of its biennial media conference in Rangoon this week. In many respects, it serves as a testament to how far press freedoms in Burma have progressed over the past two years.
Analysis Contributor Lead Story News
Dr Nyo Tun offers an insight into the harsh realities of Burma's 'mental culture', using the recent Wirathu – Win Tin debate as a basis.
An amended Ant-Terror Bill passed through Burma's lower house Monday. The Bill focuses on blocking terrorist funding in Burma but includes clauses on nuclear materials and facilities.


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Oven Roasted Sausage, Potatoes and Peppers. 1.spray a large baking pan w/ nonstick spray. 2.slice sausages into thin rounds, about 1/5″ thick. 3.cut potatoes into 1/2″ chunks 4.slice onion and pepper into strips 5.place all ingredients on baking sheet and drizzle oil over. 6.add salt & pepper and spices 7.top w/ sliced banana peppers 8.bake at 400 for about 30-35 min.
Oven Roasted Sausage, Potatoes and Peppers. This is really good!!! I'm going to try this with turkey sausage.
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Loaded Mashed Potato Bake OH MY STARS THIS WAS DELISH! DO NOT USE 'I CAN'T BELIEVE IT'S NOT BUTTER'...USE REAL BUTTER!! : ) Mandy


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Research Summary
David Liu's research integrates chemistry and evolution to illuminate and program biology, especially toward the development of new therapeutics. His major research interests include (1) the discovery of therapeutically relevant synthetic molecules using DNA-templated synthesis, a technique developed in his laboratory, and Darwinian selection; (2) the characterization and engineering of genome-editing proteins toward next-generation human therapeutics; and (3) the laboratory evolution and delivery in vivo of proteins that modify information flow in human cells.
The past century of life sciences research has resulted in an emerging understanding of the ways in which DNA, RNA, proteins, and small molecules regulate information flow in living systems. This understanding has made increasingly realistic the possibility of not just reading but precisely manipulating biological information in humans by changing the structure of our genomes, altering gene expression patterns, engineering new conditions under which genes are expressed, and creating new circuits that interface exogenous synthetic molecules with gene expression programs. The purposeful manipulation of information flow in human cells and patients has the potential to (1) reveal and validate causal relationships among genes, gene products, and human disease and (2) lead to breakthrough small-molecule or macromolecular therapeutics that address disease at the most fundamental level of our software, the human genome, as well as at the level of gene products.
Although the vision of manipulating gene sequences, gene regulation, and gene products with molecular precision in mammalian cells—and, eventually, in humans—has enormous potential to benefit society, several daunting challenges must be overcome before this vision can be fully realized. Perhaps the most significant of these challenges is how to create with a practical efficiency and success rate the many protein or nucleic acid machines that are needed to alter genomes, transcriptomes, or proteomes with a sufficiently high degree of selectivity and potency. To realize a vision in which arbitrary genes, transcripts, or proteins can be manipulated in mammalian cells requires fundamentally new approaches to generating, at an unprecedented scale, protein or nucleic acid machines with precision, tailor-made properties.
These approaches will likely exploit recently discovered natural proteins, coupled with state-of-the-art technologies such as phage-assisted continuous evolution (PACE), by rapidly evolving and engineering these proteins toward uses that advance the science of therapeutics. For example, the creation of robust platforms of programmable CRISPR (Cas9)-based or TALE-based genome editing and transcriptional regulation tools that are capable of turning "on," turning "off," or altering the nucleotide sequence of any combination of genes or regulatory sequences in the human genome represents an ambitious but well-defined goal that would have a major impact on illuminating disease biology and potentially treating genetic diseases.
In addition to evolving and engineering macromolecules, discovering and developing small molecules that can modulate the biological activities of targets validated using programmable genome-engineering proteins are essential activities to connect new biological insights to leads for therapeutic development. Some targets may only be addressable using macromolecular therapeutics by virtue of their binding energies and ability to catalyze transformations such as manipulating the covalent structure of genes and proteins. For other targets, however, small molecules will likely remain the most promising class of agents to modulate activities in therapeutically relevant contexts. Therefore, the development and application of new, highly efficient small-molecule discovery technologies such as the selection of DNA-encoded small-molecule libraries against many biological targets of interest in a single experiment will play crucial roles.
The activities needed to realize this vision can be classified into the following three phases:
Phase 1: Develop the tools. New methodologies and technologies to characterize, engineer, and evolve proteins will be developed and applied to transform natural components such as Cas9 or TALE domains into variants with the specificity, context independence, activity level, stability, cellular compatibility, and effector functions necessary to illuminate or address human disease. These effector functions will likely include DNA cleavage, transcriptional activation, transcription repression, epigenetic modification, and recombination to insert, delete, or replace alleles. Although these activities have become a focus of several laboratories, including our own, many of the key developments and insights have either not yet been reported or only very recently been described. Importantly, TALE- and CRISPR-based systems are programmable using a simple code that relates target DNA sequences with TALE or CRISPR protein or RNA sequences. Because this programmability alone—although crucial—is insufficient to ensure that these tools will be robust or accessible enough to support Phase 2 and Phase 3 activities, methods to rapidly characterize and improve these tools must also be developed.
In addition to programmable DNA-binding proteins and protein–RNA complexes, other macromolecules capable of manipulating biological information flow in human cells—including antibodies, proteases, sortases, recombinases, polymerases, and nucleases—are also poised to play key roles in the understanding and treatment of disease. As is the case with TALE and CRISPR systems, a primary determinant of the likely impact of these proteins is our ability to engineer or evolve therapeutically relevant levels of activity, specificity, stability, or cell-state dependence. Therefore, general methods such as high-throughput specificity profiling or PACE that can efficiently characterize and improve diverse classes of proteins may prove especially valuable to Phase 1 efforts.
Phase 2: Discover the programs. Sets of evolved or engineered macromolecules generated in Phase 1 will be used to discover and test causal relationships between genes and disease-associated pathways in mammalian cells. As Phase 1 methods become increasingly effective, and ever larger sets of these tools become accessible, Phase 2 activities will transition from a hypothesis-testing mode (Does gene A when upregulated and gene B when downregulated induce disease if gene C is mutated?) into a hypothesis-generating mode ("forward genetics") with the goal of discovering sets of genes or proteins that when activated, repressed, or modified alter the propensity of human cells to enter a diseased state.
Phase 3: Enable therapeutics. The knowledge from Phase 1 and Phase 2 will trigger new drug discovery efforts through the identification of new targets for small-molecule screening and development. In addition, the programming tools themselves, if sufficiently specific and active, have potential as macromolecular therapeutics. Phase 3 efforts therefore will aim to develop both small-molecule and macromolecular therapeutics that program human cells in the ways discovered in Phase 2. The macromolecular side of this phase will require characterizing and improving delivery (using new delivery technologies such as supercharged proteins), biodistribution, immunogenicity, and efficacy studies in cell culture and animal models of human disease.
Implementing this ambitious vision in a way that has an effect on society outside of the laboratory will foster—and require—a multidisciplinary, highly collaborative culture that seamlessly integrates chemists, synthetic biologists, macromolecule engineering and evolution experts, cell biologists, clinicians, bioinformaticists, industry experts, and entrepreneurs.
Specific examples of transformative applications include
- Revealing the genetic dependencies of oncogenesis, infectious disease progression, and metabolic disorders in therapeutically relevant settings;
- Programming the expression of sets of transcription factors that induce the differentiation or transdifferentiation of therapeutic cells (e.g., pancreatic exocrine cells into beta cells in diabetics, white adipose tissue into brown fat in patients with metabolic disorders, or serotonergic neurons into dopaminergic neurons in patients with Parkinson's disease);
- Altering the structure of the genes in infected individuals to disrupt the life cycle of infectious disease agents (as a validated example, editing CCR5 in patients with HIV);
- Programming cells containing cancer- or infectious disease-associated genetic changes to undergo apoptosis; and
- Implicating genes and gene combinations that grant resistance or sensitivity to known bioactive molecules for which there is no target known.
Other support includes grants from the Defense Advanced Research Projects Agency and the National Institutes of Health.
As of October 17, 2014


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Yesterday, my kids opened a drawer in the dining room that was packed with retired bibs. They were sort of excited to see the bibs, as if they were old friends. When I realized we don't use bibs at all anymore, it seemed obvious what their future would be: stuffed animal capes.
Julian had a whole plan about how he was going to entertain younger children by flying these guys around attached to a rope. He was not going to let the younger children touch the stuffed animals. (His plan was flawed.)
I was thinking I'd just put a star in the center of the bibs with a Sharpie, but
the dictator Julian had a more specific process in mind. Ultimately, we ended up with a Wonder Pets-inspired look. I think a less costume-obsessed child would probably be ok with an unadorned bib.
Latest posts by Whitney Moss (see all)
- 6 reasons CVS is awesome for parents - November 25, 2014
- When to use black and white photo filters - November 21, 2014
- 10 Clutter-Free Gifts for Dads & Husbands - November 20, 2014


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In this tutorial we will create a really beautiful and simple flat drop down menu using HTML and CSS only. We are not using any JavaScript or jQuery plugin to achieve the drop down effect. This will be a simple, neat and clean flat drop down menu which will follow the current flat UI trend in the design industry. So let's start creating our simple drop down menu.
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Apr 18 2013 / 01:04


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The official San Diego Chargers pre-game show.
The Chargers and the San Diego Blood Bank are gearing up once again for one of the community's longest running and most successful life-saving events of the year; Chargers Blood Drive XXXVI.
The official San Diego Chargers pre-game show.
The official San Diego Chargers pre-game show.
Your own private Chargers Luxury Suite. Is there any more prestigious way to entertain? Enjoy plush surroundings, protection from the elements and, best of all, a truly remarkable view of the field. This is the environment to build relationships and expand business opportunities. Solidify the core of your business while creating memories and an experience that your clients, employees and friends will enjoy—and remember—long after the game is over.
Virtual Venue I Premier Suite Seats I Single Game Suites I Gameday Hospitality I Luxury Seating Map, Qualcomm Stadium | Handbook
For more details on Luxury Suites, or to request information, click here or call 877-CHARGERS option"4"


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Weak Demand, Oversupply Dampen Oil Price
Oil – Despite tension in the Middle East, oil is still on a downward swing. What impact could the North American market feel from a prolonged oil price decline?
Oil – Despite tension in the Middle East, oil is still on a downward swing. What impact could the North American market feel from a prolonged oil price decline?
Silver – This morning, silver rose 0.3 percent, or $0.06, hitting $20.06 per ounce. Investors are seeking a safe haven against the risks of global conflict, particularly as some see the situation in Ukraine escalating.
When political tension hits, the price of gold almost always increases on safe-haven demand. Such was the case today.
Oil – Reuters reported today that oil prices have fallen as worries have subsided regarding supply interruptions in Libya and Iraq.
Oil – Writing for Time, Bryan Walsh explored the future of oil exports from the United States in light of increasing violence in Iraq. Although he noted that it is not easy to predict the future of oil and energy, Walsh suggested that the U.S. could play an even bigger role on the global oil and energy markets in the future.
Oil – Reuters reported today that prices for Brent crude oil fell as fears surrounding the impact of violence in Iraq on oil exports subsided. However, U.S. oil prices were up following a decision by the U.S. government to allow exports of lightly refined oil.
Silver – Today, silver rose 1.3 percent, or $0.27, hitting $21.09 an ounce, its highest price since March.
Gold – Gold took a big jump at the end of last week, spurred by further tension in Iraq and comments from Federal Reserve Chairwoman Janet Yellen.
It was a good week for metals, with gold climbing to a nine-month high this week. Silver and copper also took strides in an upward direction. Crude, on the other hand, dipped slightly.
Oil – Bloomberg reported that Brent Crude reached a Nine-month high in London today, rising to $115 a barrel on continued tensions in Iraq.
Get our independent commentary on resource trends and companies delivered to your inbox.
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Related quotes
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"We played a box-and-one and it gave them some room to get inside and flash in for a rebound. Then there were times where we had the inside and a long rebound would pop back out."


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What happens when a religion demonizes women and puts them out of sight and mind?
The Dancing Boys of Afghanistan
April 18, 2011 by 15 Comments
March 6-8, 2015
Terrenea Resort
Palos Verdes, CA
How Palestinian Nazis speak: Blessed are your axes. palwatch.org/main.aspx?fi=1…
I understand the traitor John Kerry is headed for the UAE to plead with them to remove the terrorist front CAIR from their terrorist list.
Oh yes, and Sharpton is also a crook, which is why he is in financial trouble: nytimes.com/2014/11/19/nyr…


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- Filed Under
In the current debate over what to do, if anything, about the situation in Syria, I thought it might be helpful to look, albeit briefly, at the Western and Christian tradition around just war. At the moment, we've been given a bit of breathing space as the diplomatic effort moves forward.
No one doubts that a diplomatic solution would be a godsend. How does a nation decide for or against war or even intervention? Right now, it seems that the majority of Americans are basing their decisions on a combination of fatigue and the desire for isolation that is a result of that fatigue.
This position is ...


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Love Sms - Find largest collection of Love Sms messages at Hamariweb.com submitted by user, get all the fresh Love Sms text messages, Quotes, Wishes, Greetings in Urdu, English & Roman Urdu to send mobile sms your friend & family members in Pakistan now.
You may meet people who're:Better than meFunnier than meMore beautiful than meBut one thing I can say to you - I'll always be there for you when they all leave you!
Love bears all things;Love endures all things;Love hopes in all things;Love believes in all things.Come, let's fall in love!
Sari Dunya k Rivajon sy Adavat ki thiMujhay yad hy jb mein nay muhabat ki thi
You learn to like someone when you find out what makes them laugh;But you can never truly love someone until you find out what makes them cry!
Love is the path that leads to happiness.However, it's so narrow that two can't walk on it unless they become one!
"True love stories never have endings."
"Love is not a matter of counting the years … But making the years count."
Strength grows when we dare;Unity grows when we pair;Love grows when we share;And relationships grow when we care!
Love is like a cloud, love is like a dream,Love is one word and everything in between,Love is a fairy tale come true,Because I found love when I found you!
"Don't expect a perfect love from any of your close ones...Just show them what it is..."
Love means.L: Lifes PurposeO: On the way of EmotionV: Valley of JoysE: End of sorrows.I wish you Life be filled withlove
"I LOVE YOU because i need you"because i love you so muchLOVE is composed of a single soul inhabiting two bodies
Your task is not to seek for love, but merely to seek and find all the barriers within yourself that you have built against it.
What is special in Love?Nothing special.It has two vowels, two consonants and two fools!
You're like Asthma - you take my breath away.Like Dandruff - I can't get you off my head.Like my Car, you drive me crazy.Like Dentures, I can't smile without you!
Love Is Like A Ice Cube,the Harder U Hold On To It,the Faster It Disappear.All you Have In your HandWill Be Tears Of Crushed Love
My love for you is like a fractal - it goes on forever.
Once you have feelings for someone,Those feelings will always be there,You may not like them anymore,But you'll still care!
Dreams are made for believers;Believers are made for dreams;But I'm made for you and that's a reality!
Love is composed of a single soul inhabiting two bodies.
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Signs in the Blood
By Vicki Lane
(Dell, Mass Market Paperback, 9780440242086, 400pp.)
Publication Date: May 31, 2005
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Enter your zip code below to find indies closest to you.
Elizabeth Goodweather and her husband built a rewarding life in the hills and hollows of their adopted Appalachian home. But now Elizabeth is alone, her husband tragically killed, her children grown, the land around her filled with customs and beliefs she cannot share. It's still a good life–tending the small herb and flower business–but Elizabeth's fragile peace is about to be shattered.
Cletus Gentry vanished while hunting ginseng in the hills–and his mother is sure the childlike man was murdered. As Elizabeth retraces Cletus's last wanderings, she will discover that a killer has been waiting all the while in the coves and hollows near her farm for her to see the light…and then come willingly to her own death.
Vicki Lane lives with her husband, two sons, and daughter-in-law on a mountain farm in North Carolina. She has completed her second Elizabeth Goodweather novel and is at work on the third.
"[A] well-crafted, dramatic tale of murder, miracles and midlife romance..... Lane utilizes exotic religions to intensify the book's dark-toned suspense, while resisting oversimplification and insult. Her heroine's open-minded fascination with beliefs not her own should appeal to an unusually wide readership."--Publishers Weekly


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Salmon Grilled Between Romaine Lettuce Leaves
- Total Time:
- 30 min
- Prep:
- 20 min
- Cook:
- 10 min
- Yield:
- 4 servings
- Level:
- Easy
- 4 (3-foot) pieces of twine, or other non-flammable natural fiber
- 4 (6-ounce) salmon fillets
- 8 large outer romaine lettuce leaves
- 2 teaspoons olive oil
- 3 lemons, 2 juiced, 1 sliced thinly
- Salt and freshly ground black pepper
- 4 teaspoons capers
- 8 sprigs fresh dill
Soak twine in hot water for 5 minutes.
Rinse salmon in cold water and pat dry with towel.
Repeat the following for each salmon steak: Rinse 2 romaine leaves in water, shake off excess water. Drizzle 1/2 teaspoon of oil over the inside (concave) side of leaves.
Place salmon fillet in the center of 1 leaf (concave side up).
Pour the juice of 1/2 lemon over salmon, trapping the drippings with the leaf. Season with salt and pepper. Top with 1 teaspoon capers, 2 sprigs of dill, and 1 lemon slice.
Place the second leaf, concave side down, over salmon. Fold the ends of the bottom leaf up to keep juices trapped, and wrap the string around the leaves to seal. Tie string in a knot.
Preheat oven to broil. Set rack in the highest position.
Broil romaine-wrapped salmon for 5 minutes per side. The lettuce will blackenthis is a good thing. Cooking time will vary according to the exact thickness of the fillet. (Salmon can also be grilled over direct heat for 5 minutes per side).
To serve, instruct guests to cut string and remove top leaf. Yes, they can eat the blackened lettuce.
Recommended beverage: Pinot Noir (if salmon is farm-raised), Zinfandel (if salmon is wild)
Recipe courtesy Bob Blumer
More Recipes and Ideas
Grilled Shrimp in Lettuce Leaves with Serrano-Mint Sauce
Recipe courtesy of Bobby Flay
Grilled Salmon with Sherry Vinegar-Honey Glaze and Spicy Tomato Relish
Recipe courtesy of Bobby Flay
Grilled Salmon with Merlot Pan Sauce
Recipe courtesy of Emeril Lagasse


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Recent Stories
- Top that!
- University and industry collaborations recognised by prestigious award
- Forty South Lakes Science teachers visit the faculty
- Physics PhD student wins EPSRC Doctoral Prize
- New network for particle accelerator engineers
- Faculty leads new initiatives to stimulate postgraduate teaching and business innovation
- Lancaster research to help business decision-makers protect against cyber attack
- Lancaster University helps British fishing tackle manufacturer reel out new product
- Research institute opens in China
- Lancaster University engineers help discover the world's biggest cave
How grazing helps grasslands thrive
Story supplied by LU Press Office
Grazing animals are improving biodiversity by increasing the amount of light available for plants at ground level.
The research, published in Nature, is by an international team of scientists led by the University of Minnesota and including Lancaster University.
Understanding the interplay among fertilisers, herbivores and plant growth is critical to our capacity to feed a growing human population and protect threatened species and ecosystems.
Scientists at 40 sites on six continents set up research plots with and without added fertilizer and with and without fences to keep out the local herbivores such as deer, kangaroos, sheep or zebras.
One of the sites is in Lancashire where the researcher was Dr Carly Stevens, of Lancaster University's Lancaster Environment Centre, who said: "This experiment demonstrates how grazing shapes our grassland ecosystems and provides benefits to biodiversity. By carefully managing grazing in grasslands habitats hopefully we can offset at least some of the damage that can be done by fertilisers".
The scientists measured the amount of plant material grown, light reaching the ground, and number of species of plants growing in the plots.
When the researchers compared data across the 40 study sites, they found that fertilizing reduced the number of plant species in the plots as species less able to tolerate a lack of light were overshadowed by fast-growing neighbours.
On both fertilized and unfertilized plots, where removal of vegetation by herbivores increased the amount of light that struck the ground, plant species diversity increased.
These results held true whether the grassland was in Minnesota, Argentina or China, and whether the herbivores involved were rabbits, sheep, elephants or something else.
The findings add a key piece to the puzzle of how human impacts affect prairies, savannas, alpine meadows and other grasslands.
The study was made possible due to the formation of the Nutrient Network, also known as NutNet. This is a collaborative international experiment as a resource to understand how grasslands around the world respond to a changing environment.
Mon 10 March 2014
Latest News
Top that!
Students and staff this week witnessed a significant development in the construction of two new super-labs providing teaching space for more than 200 students.
Wed 26 November 2014
University and industry collaborations recognised by prestigious award
Lancaster University and resident company The REACH Centre have been recognised for their outstanding track-record of working together at a prestigious award ceremony.
Story supplied by LU Press Office
Wed 12 November 2014
Forty South Lakes Science teachers visit the faculty
On 24th October, forty teachers from across the South Lakes area visited the Faculty of Science and Technology, as part of a partnership between Lancaster University, Research Council UK, and the South Lakes Federation.
Thu 06 November 2014
Physics PhD student wins EPSRC Doctoral Prize
Peter Hodgson, who has just successfully defended his PhD, has now rounded off the achievement with the award of an EPSRC Doctoral Prize by the Faculty of Science and Technology.
Thu 30 October 2014


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Map | Pre-paid Parking
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QTH: OLSZEWO-BORKI, POLSKA: R, SPPA: OR, PGA: OR09, Loc: KO03sb.
NOTE! We have a new postal address valid since August 1, 2014.
My XYL is Barbara/SQ5BB. We are living in Kurpie region (note traditional costume on our QSL card) located in N/E part lowland plain called Mazovia (Mazowsze) of Poland (near town of Ostroleka). More info visit http://en.wikipedia.org/wiki/Kurpie .
Our local radio club is SP5KVW in Ostroleka.
Recently I am focused on 15m, 20m and 10m bands JT65A digital mode.
QRV on 20/15/10m PHONE and DATA (PSK31 PSK63 JT65A JT9) barefoot into portable style home made wire antennas:
1) 20m - 1/4 "triple leg" wire vertical on the 7m fishing rod,
2) 15m - 3 el square shape Moxon wire beam,
3) 10m - 3 el square shape Moxon wire beam.
FM SAT skeds are possible.
Paper QSL's via PZK QSL Bureau (SP5 OT-25) or direct.
Electronic QSL's via LoTW and eQSL(AG).
73 de Andy/SP5XSD
1296831 Last modified: 2014-09-26 17:29:36, 1870 bytes
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Yilda Diaz has seen her son, Royals catcher Salvador Perez, take on a leadership role since his days on youth baseball teams at Club Firestone in Valencia, Venezuela. Perez homered in Game 1 and stroked a clutch two-run double that helped the Royals ea... Read More »
Home | Tag Archives: leadership
Superintendent Mann Award
Norton Community School Superintendent Greg Mann has been named the Kansas School Superintendents' Association (KSSA) 2011 Distinguished Service Award recipient. Mann was recognized by fellow superintendents during the recent Council of Superintendents meeting at the State Department of Education in Topeka on February 23rd. Each year, KSSA recognizes a superintendent for outstanding contributions and exemplary leadership – in the organization ... Read More »


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Bel: "Chloe your curry roots have got really bad."
Chloe: "I know, it sucks."
Chloe: "I know, it sucks."
by chloewhitexxx May 05, 2011
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Welcome to the WKHS Counselors website. We hope this website will provide easy access to information students and parents may find helpful. Please bear with us as we continue to add content to the site. If you have any suggestions or requests for information that you would like to see on the website, please let your counselor know so that we can add it to the development list.
Attached please find the powerpoint slides from the Junior Student/ Parent College Information Night presentation held at Worthington Kilbourne High School on October 29, 2014.
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valid XHTML and CSS.


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Guru3D Rig of the Month - November 2014
Dragon Age: Inquisition VGA graphics performance review
MSI 970 Gaming motherboard review
Corsair Gaming M65 RGB game mouse review
MFAA Multi-Frame Samples AA Explored - Guide
GSKILL Phoenix Blade 480GB PCIe SSD Review
Corsair Gaming H1500 Dolby 7.1 headset review
GALAX GeForce GTX 970 EXOC Black Edition review
Guru3D Contest 2014 - Win a Gigabyte GTX 980 G1 Gaming
Call of Duty Advanced Warfare VGA graphics performance benchmark review
Detonator 31.50 Windows 98|ME
Posted by: Import on: 02/01/2004 04:20 AM [ 0 comment(s) ]
Windows 98/ME This is a new set of Detonators 31.50 For Windows 9X/ME. This set works on all known NVIDIA based graphics cards to date and was released by Compaq. Your graphics card does not have to be from Compaq though as these are generic drivers.

Self Extracting archive, a very easy setup ;)
« ATi CATALYST 2.4 Windows 2000|XP · Detonator 31.50 Windows 98|ME · SoftQuadro 4 »


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Texas Roadhouse - Review about Steak from Fairmont, West Virginia
- Nov 22 2014-11-22 17:08:09
Texas Roadhouse
Texas Roadhouse is a publicly traded chain restaurant that specializes in steaks and promotes a western theme. The company is an award-winning, full-service restaurant chain featuring hearty, hand-cut steaks, fall-off-the-bone ribs and hot, fresh-baked bread and more. The company was founded in 1993 in Indiana by Kent Taylor. The chain operates about 340 locations in 46 states. Their main suppliers are Tyson Foods and Smithfield Foods. Texas Roadhouse serves American Cuisine, including steak, ribs, chicken, and seafood. For the customers' convenience in the waiting room (as well as at all tables) the restaurant provides free in-shell peanuts. Most restaurants offer entertainment in the form of line dancing. Texas Roadhouse Restaurant is offering a certificate for a free Cactus Blossom with the next purchase of two entrée.6040 Dutchman's Lane Louisville KY 40205
- Cafes and Restaurants
- Fairmont, West Virginia
- Steak
- 17
We have always enjoyed going to texas road house. We always got the dallas filet, which was very good. Yesterday we went and decided to try other steaks such as the ribeye and the new york strip. I wouldnt have fed neither steak to a dog. They were tuff and non tasting and expensive. My husband asked for loaded sweet potato, which is suppose to have marshmallie, cinnam I n and carmel. He got a... Read more ›Was this review helpful? 0 0 2.5


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7 out of 10 | Michael stayed December 26, 2013
"mike barber from ottawa."
"The petit dejeuner was tres petit. Coffee barely warm at 7 a.m."
10 out of 10 | Rose stayed January 09, 2011
"Staying there again for sure."
"Location is Perfect. Comfort is excellent. Just real good deal for the price too."
6 out of 10 | Verified Guest stayed August 01, 2010
"I find it expensive for what it's worth....also, when we went in our room, we were 4 but there were only two towels. As well as there were only two pillows. But mostly I found it expensive, however, I would recommend it as the room was nice."
2 out of 10 | Verified Guest stayed December 06, 2009
"Worst hotel I have stayed at. Still dealing with bug bites from the extremely dirty bed covers."
8 out of 10 | Peter stayed April 27, 2006
"A convenient walk to local attractions. Hotel staff very helpful in finding information about local attractions. Room was very clean."
9 out of 10 | Verified Guest stayed September 12, 2004
"Please take better care of your blue fish in its lonely jar on the counter. He needed a plant, a bigger space, more water, and food ... and especially some friends. I worried about him."
8 out of 10 | Verified Guest stayed August 16, 2004
"The first night of our stay (saturday the 14th), there were young adults on our floor that were excessively noisy and out of control through all hours of the night, twice they knocked on our door loudly and once even entered our room. We slept very poorly on this night and were very tired for our sightseeing the next day. The staff however was pleasant enough."
9 out of 10 | John stayed January 04, 2004
"great hotel"


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I'm very happy with the purchase of this item,,, also had the best price and thePublished 1 month ago by FELIX ANTONIO MEJIAS HERNANDEZ
This phone only works when charging. Cannot even make a call and it turns off. Limited apps..Published 1 month ago by anna
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Good phone but can't send or get pics. And it won't update....Published 2 months ago by Jennifer Flowers
Piss poor.... It was supposed to be a new phone when I got it......started having problems with it and called Samsung...IT WAS OUT OF WARRANTY!!!!!!!! Read morePublished 3 months ago by Daniel J.Koon
This is Windows OS phone. Few apps are available for it. It has very little product support. It works well.Published 3 months ago by Ham Bone


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Make beats and rap, I am Blade, I am Whistler
from G-Eazy (Ft. Aquaforce, Chippy, Skizzy Mars & Sonny Shotz) – Outta Pocket RMX Lyrics on Genius
G is referring to the characters in the Blade trilogy films. Blade did all of the "front-man" action (rapping in G's case) while Whistler was behind the scenes, making sure everything was perfect for Blade. Since G is both behind the scenes tweaking his instrumentals/mixes and rapping, he refers to himself as Blade and Whistler-the dynamic duo, or solo per se.
To help improve the quality of the lyrics, visit "Outta Pocket RMX" by G-Eazy (Ft. Aquaforce, Chippy, Skizzy Mars & Sonny Shotz) Lyrics and leave a suggestion at the bottom of the page


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Home » News » Public Safety
In wake of Pariseau high-rise fire, Manchester housing officials consider smoking ban
The housing authority has so far resisted calls from the federal government to convert the authority's 1,271 apartments into smoke-free zones, but officials said it will be discussed, at least informally, among the governing board of the authority.
"Obviously, with what's happened at the Pariseau, it's something the board should talk about," said George Copadis, chairman of the housing authority Board of Commissioners. "It's a double-edged sword; these folks, basically it's their homes."
Last year, the U.S. Department of Housing and Urban Development encouraged directors of public housing authorities to make some or all of their properties smoke-free. Most public housing authorities in New Hampshire have banned indoor smoking - including apartments. But the larger authorities, such as Manchester, Nashua and Concord, have not, according to data compiled by the New Hampshire Tobacco Prevention & Control Program.
Some housing authorities have been smoke-free for years.
At the 580-unit Portsmouth Housing Authority, a smoking ban went into effect in July 2009, said Craig Welch, the newly named executive director. He said the smoking restrictions protect the health of non-smoking residents and employees.
Tenants can smoke, but not in their apartments or indoor common areas. Some of Portsmouth's larger projects offer outdoor smoking areas.
"It's still difficult," Welch said, adding that mentally ill tenants are the ones who most often violate the smoking ban. Although no one has been evicted for violating the smoking provisions of their lease, that is possible, he said.
The 250-unit Laconia Housing Authority went smoke-free in August 2011. Smoking is prohibited on housing authority property entirely. Interim Director Claire LaMay said if smoking were allowed outdoors, smoke could drift into apartments.
"We do not stop people from smoking; they just cannot smoke on our property," she said,
Both housing authorities gave lengthy notices of the change in policy. No-smoking provisions were added to individual leases when they came up for renewal. And the authorities offered smoking cessation programs to tenants.
Stewart Property Management, which manages privately owned, low-income apartments in New Hampshire, has also taken steps to make its properties smoke-free, including the downtown Carpenter Center in Manchester.
HUD urged public housing authorities last May to make the change, noting that the elderly, youth and people with chronic illness are especially susceptible to second-hand smoke and related illnesses such as heart disease, respiratory problems and cancer, HUD said.
It also said that smoking is the leading cause of fire-related deaths in multi-family buildings, based upon a 2005 report. The HUD recommendations are not binding.
Dick Dunfey, executive director of the MHRA, said a no-smoking policy has been discussed at the staff level. Currently, smoking is prohibited in common areas such as hallways and activity rooms.
He said tenants haven't been pressing for a smoking ban. Several months ago, one resident complained about cigarette smoke around the entrance of a building. The staff encouraged smokers not to smoke so close to the entrance, and they complied, he said.
Dunfey is cool to a ban, and said it's not wise to set policy based on a single incident, such as the Pariseau fire.
"Residents of Manchester Housing and Redevelopment Authority properties are living in their homes," Dunfey said, "they have the right to the peaceful enjoyment and liberties of their own homes."
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Added Apr 3, 2012
Visby, Sweden
Flower made in organza fabric, my first organzaflower ever.
Jul 11, 2013, 09.00 PMby jennyrecorder
I make these too, easy and very different :) I got the idea from my sewing teacher who sells hers (hand sewn) for AUD $50!!! I love your symmetry, very professional.
Jul 11, 2013, 09.09 PMby Madcinderella
Thank you Jenny for saying that my flowers look professional! :D
Apr 14, 2012, 01.15 PMby Madcinderella
You are welcome =D I´m not that good in english so I hope you understod a little of what I ment!
Apr 3, 2012, 11.59 PMby micbrown
Nice, how did you make it?
Apr 4, 2012, 04.15 PMby Madcinderella
Thank you!!! =D
It was realy simple, I just cut out seven or eight circles in diffrent sizes, and then cut little cuts around the circles…
Took a candle and burnt the edges VERY gentley.
Then I laid the circles in size after each other and sew them together whit invisible thread and a pearl.
Apr 10, 2012, 12.46 AMby micbrown
Cool. I am going to give it a go.I would like add a pin to the back so I can wear with a jacket. Thanks for the instructions :)
Add to Favorites 2 people added it
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Seams divide the front for a detail minimalists will love! (This pattern is also a part of our sale)
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NASDAQ:VECO Technical AnalysisNASDAQ:VECO - Veeco Instruments Inc.VECO - Sector: Technology, Industry: Semiconductors.VECO lost -0.56% on 11/28/14.VECO is trading in the range of $0.00 - $37.73 in the past 30 days. Money Flow Index (MFI) is bullish and moving up for VECO.Relative Strength Index (RSI) is bullish and moving up for VECO.Relative Strength Index (RSI) is bearish and moving down for VECO.Commodity Channel Index (CCI) is bullish for VECO.Stock Performance on Mondays in the past 90 days: -3.36%Stock Performance on Tuesdays in the past 90 days: 0.90%Stock Performance on Wednesdays in the past 90 days: -0.55%Stock Performance on Thursdays in the past 90 days: 14.28%Stock Performance on Fridays in the past 90 days: -3.28%Stock Rating: Buy with a score of 4/5.
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"Did you ever think of the many things you've learned to do?" "Did you ever grow anything ... in the garden of your mind?" Those are the kinds of gentle, encouraging questions children heard during Fred Rogers' PBS television show, "Mister Rogers' Neighborhood," over the course of three decades.
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1/1 Photo of Red Lobster White Cheddar Mashed Potatoes Recipe
Prep Time:
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The is a copy cat recipe of the Red Lobster White Cheddar Mashed Potatoes. I love them but Red Lobster doesn't carry them any more. they are quite easy to make.
Units: US | Metric
Serving Size: 1 (305 g)
Servings Per Recipe: 4
Every recipe, menu, tip and how-to is right here, at your service.


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Town Square
Attend the 81st annual Contra Costa democrats BBQ
Original post made on Aug 10, 2012
Read the full story here Web Link posted Thursday, August 9, 2012, 10:22 AM
Comments (1)
a resident of Alamo
on Aug 10, 2012 at 6:44 am
Democrats BBQ? Sounds good to me... and be sure not to miss the big Democrat BBQ in November. See you at the polls.
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The Giving Season
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Thanksgiving Transfer Fever!
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Thankful season for ValleyCare
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Anyone at the Dad Vails this afternoon who didn't know this before today is completely cured of their ignorance, as the Boilermakers took the final two premier races of the day, the men's and women's varsity eights, and nabbed the overall points trophy in the offing. The women's eight got a full Boiler Up treatment, then the men got the same, and finally the entire program chimed in when the points were finally tallied; you could say it was a day made for a Boilermaker.
Purdue chalked up a few big firsts today; despite having taken the points trophy something like seven of the last 10 years, this is the school's first gold medal in the men's eight, and (obviously then) the first time they won both the big eights events. (This has happened only twice before since the addition of the W8 in 1976, when Temple did it in 1994 and 1996). The Purdue women did win the eight previously, 10 years ago.
The Purdue women came into the event seeded fifth, largely due to inconsistent racing this season, according to coach Jake Hatch.
"The crew is strong and they row well," he said, "but they have been up and down this season with trouble getting their racing together from a maturity standpoint. It has been a learning year for us, and it all came together today."
Men's coach Dave Kucik was not surprised by his crew's win, but he was clearly emotional on the medals dock, and his admiration for the crew's effort showed. "You always think you can win," Kucik said, "but this crew had a little something special." Kucik chalked it up to "a bit of synergy. A few of these guys won the frosh eight a couple years ago; there are a few different people in this crew, but there is really a lot of desire and a lot of fight in the crew."
As to taking both eights, Kucik exclaimed "It's just awesome. It should be a great ride home."
More notes from the Vails: Dowling crews took two gold medals today, and still have the international feel they have become known for; after a win in the women's DII/DIII eight, in which crew Dowling has six international students, considerable parts of the celebration were conducted in other than English; in the men's four, the crew was forced to break down from an eight earlier this year when three crew members, two from Poland and one from Slovakia, had to head home to try out for their respective Olympic teams, according to men's coach Frank Pizzardi, Jr.
The Georgia Tech light eight repeated as champs this year, and should contend for another run next year; the crew returned five members from last year's eight, and will return six from this year's eight in 2008.
Fordham's win in the men's four is their fifth in the past few years. The young crew, which includes a junior, two sophomores, a frosh, and a junior coxswain, found their speed earlier this year at the Murphy Cup when they drew Dowling in a one-to-the-final heat that also was to include a "fastest time" qualifier. "They had some trouble with the stakeboats due to the big storm, so they dropped the fastest time qualifier," said coach Ted Bonanno. "So I told the guys, well, you have to have the fastest time – you have to win!" The crew met the challenge, and hasn't slowed down since.
The Cal State Long Beach silver medal light women's eight all but came out of nowhere –literally. The crew includes six novices, four of whom did not row before February, according to coach Brent. "They're decent athletes, but they didn't come to rowing from other sports; we just picked them off campus," he said. "They all decided they wanted to go to the IRA, tho, and they showed up 20" early for every practice, every day, to do the work to make it happen."
Finally, I may have this wrong, but I'm pretty sure Ohio State won the women's point trophy; if I'm right, that' not bad for a club program that rows in the shadow of a big DI squad.
row2k Interview: Kaffe Break with Olympic Rowing Champ Olaf Tufte (November 25, 2014)
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Book Review: Flat Water Tuesday (November 4, 2014)
The Philadelphia Challenge Cup, from 1920 to 2014 (October 24, 2014)
2014 USRowing Fan's Choice Awards (October 1, 2014)
Carolina Rowing Signs Seven(November 26, 2014)
Nottingham send team of ten to Team GB assessment day in Boston(November 26, 2014)
Deadline looms for boathouse purchase(November 26, 2014)
Boathouse project approved(November 26, 2014)
KU: Nine Sign with Kansas Rowing(November 26, 2014)
Is selecting pupils by rowing ability such a bad idea?(November 26, 2014)


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Tap Paradise Cove Answers for iPhone - iPodHome / iPhone - iPod /
Game Questions & Answers (Q&A) service lets you ask questions about video games for game consoles or PC games. So ask your Tap Paradise Cove question for iPhone - iPod and get answers from real gamers or answer questions and share your insights and experience with the rest of the gaming community.
- Developer: Pocket Gems, Inc.
- Publisher: Pocket Gems, Inc.
- Genre: Simulation General
- Release Date: Mar 7, 2012
- ESRB: Not Set
Question & Answers
Answer from: Kay
You just have to keep sending your ships out. I have usually five out at a time and the rest in bay. That's the only way I ever got them. But I'm on her wish now and I haven't been getting any
Answer from: Remag
Paradise Cove gives you a hint of the ship in Esther's Wish description (the lock on the sail). Takes these ships on long Voyages increases the amount and odds of getting tools.
The Golden Hind = coconuts
Cpt. Beth = ropes
Cpt. Johns = canvases
Answer from: Yara
I need help! I sent all my boats on long voyages and I didn't get any coconuts! even the golden hind didn't get me any :/ how should I get the FIVE coconuts?:/
Answer from: Remag
I visually got a coconut from the Hind once but didnt see any after. I agree with Kay - keep about 4-5 ships out doing short voyages. I noticed i recieved more coconuts when I sent out more ships. It's weird because I got the coconut count but wasnt sure where they were coming from! Just to let you know what I did-collect from the whales often, keep the ships out and play often. I hope this helps.
Answer from: Water nymph
I'm getting my coconuts not from ships...its from a farm called banana plantaion.
Answer from: Renee
Where did u buy banana plantation? I still got no coconut after sending many boats to voyages many times at the same time!! It's really difficult to find any coconut OMFG!!
Unanswered Questions
From: Moo
Posted on: 10-20-2014
From: TeeCie Grams
Posted on: 10-07-2014
From: Rgclive
Posted on: 09-20-2014
From: Tlcg
Posted on: 09-08-2014
From: Brenda Baby
Posted on: 09-04-2014
From: CMP
Posted on: 08-18-2014
Tap Paradise Cove - Expand your colony Trailer
- Nov 19, 2013, Views: 382
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