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TITLE: The Here and Now
AUTHOR: Ann Brashares
PUBLISHER/YEAR: Delacorte Press/2014
SERIES: No
SOURCE: I received this book for review from the publisher via NetGalley.
Follow the rules. Remember what happened. Never fall in love.
This is the story of seventeen-year-old Prenna James, who immigrated to New York when she was twelve. Except Prenna didn't come from a different country. She came from a different time—a future where a mosquito-borne illness has mutated into a pandemic, killing millions and leaving the world in ruins.
Prenna and the others who escaped to the present day must follow a strict set of rules: never reveal where they're from, never interfere with history, and never, ever be intimate with anyone outside their community. Prenna does as she's told, believing she can help prevent the plague that will one day ravage the earth.
But everything changes when Prenna falls for Ethan Jarves.
Thoughts and Reactions
I read a few reviews for The Here and Now and was prepared to hate it. I was expecting for it to not make sense, for the characters to be heinous, really any number of sins, but you know what? I actually enjoyed my time spent reading. Maybe it's because I went into it with such low expectations, but I enjoyed the novel more than I thought I would. It certainly wasn't the perfect read and I'm not running out to buy it for friends, but it was a few hours of my time well spent.
Preena is a time traveler who has come to our era with a group of others from the future in order to prevent a completely dystopian future. However, this group has taken to hiding out and has not taken any action to change the future. Preena learns through unconventional means that a turning point is about to occur and she must prevent one event from happening that could change humanity's entire course.
I have to admit that I love books that involve time travel. They don't always make sense, but there's something about the possibility of multiple time lines and time being circular that appeals to me. Even if a story's not particularly well written I'll probably like it more than I should. A lot of people who's opinions I rely on when choosing books absolutely trashed The Here and Now and a few people didn't finish it. I can understand why. The plot was convoluted and their was a not entirely successful blend of romance and mystery. However, despite the convoluted nature of the time travel I was still reading at two am. Their were logical holes in the plot that even now I can't fully wrap my mind around so I'm not even going to touch on them here.
The love story was also problematic in that it wasn't exactly fleshed out. It was love at first sight and then we jump ahead a few years to a nearly fully developed relationship. Preena and Ethan are good friends despite her community's restrictions on relationships with people native to the time. Typical star crossed lovers trope. There's really no build up or tension to their relationship. They're basically in love as soon as the readers meet them. It's not as satisfying as watching a relationship grow.
The mixture of crazy time travel drama and romance was an odd balance.They seemed to take these large breaks from their mission and it suddenly became a contemporary romance for a few chapters. It was jarring and put me off from the part of the story I was actually interested in; the crazy time travel pandemic. These breaks from the main plot combined with some of the logic holes slowed the pace down and dragged the story out. I thought it could have been much tighter; most of the action was packed into a couple of pages and the characters seemed to have quite a few deus ex machinas on their side so in the end there was a lot of exposition as opposed to action.
It was most definitely not my favourite book and I think there are definitely better time travel stories out there. I didn't however hate it and it did keep me flipping the pages until the early morning hours. It might not be the best book out there, but it kept me entertained as I read it and sometimes that's all I ask for.
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Monday, November 17, 2014
Monday, November 10, 2014
The Dream Thieves by Maggie Stiefvater | Book Review
Title: The Dream Thieves
Author: Maggie Stiefvater
Publisher/Year: Scholastic Press/2013
Series: Yes, The Raven Cycle, Book 2
Source: Purchased
Goodreads / Author's Website
Now that the ley lines around Cabeswater have been woken, nothing for Ronan, Gansey, Blue, and Adam will be the same.
Ronan, for one, is falling more and more deeply into his dreams, and his dreams are intruding more and more into waking life.
Meanwhile, some very sinister people are looking for some of the same pieces of the Cabeswater puzzle that Gansey is after...
Thoughts and Reactions
Author: Maggie Stiefvater
Publisher/Year: Scholastic Press/2013
Series: Yes, The Raven Cycle, Book 2
Source: Purchased
Goodreads / Author's Website
Now that the ley lines around Cabeswater have been woken, nothing for Ronan, Gansey, Blue, and Adam will be the same.
Ronan, for one, is falling more and more deeply into his dreams, and his dreams are intruding more and more into waking life.
Meanwhile, some very sinister people are looking for some of the same pieces of the Cabeswater puzzle that Gansey is after...
Thoughts and Reactions
In writing my review for this novel I realized that I never actually posted, or wrote, my review for The Raven Boys, the first novel of the series. Suffice to say, I loved it. I loved it so much that upon finishing it I pretty much immediately purchased it's sequel. However, that was a year ago and I just finished The Dream Thieves. That has nothing to do with the book and everything to do with my head space at the time.
I picked up The Dream Thieves time and time again with the intention of reading it, but for whatever reason I could not get passed the first few chapters. I put it down and came back to it about a week ago. I was hooked. It picks up right near where The Raven Boys left off. Adam has recently woken the ley line and nobody's sure how to act around him. Noah is becoming increasingly dim as the line is surging and causing power outages across Henrietta. Everybody now knows that Ronan can take objects from dreams and that's really the focus of this book.
Ronan is an interesting and complex character; although he wasn't my favourite going it, he grew on me as I felt like this novel really introduces us to him. He comes across as brash, but only because he cares so much. He has this ability that he doesn't understand; one that may or may not have had something to do with his father's death is and he's still trying to figure himself out. The Dream Thieves really paints him in a more sympathetic light since you really get to see his perspective.
The title essentially sums up the book. Unlike The Raven Boys where the boys and Blue are trying to find a mystical ley line, but it is mostly rooted in reality, The Dream Thieves expands upon this mystical world. Friends are dead but in the land of the living and Ronan can take things from dreams. It's crazy and thrilling. It didn't feel like a departure so much as a ramping up of the action and the world's magical nature.
I'm not sure what else to say about this book as I don't want to ruin it for anybody who has not already read it, but it thoroughly gripped me. Henrietta is more dangerous now that the line has been woken and more people are out to find it. The characters are dealing with things that they don't fully understand and it is so exciting for the reader. I love the characterizations and how fully each character is being developed. The relationships forming between them feel real and fractured and I can't think of a single character who I don't like. Even the characters who I don't like, villains like Kapuscinki, have more than one dimension and are compelling.
I am now thoroughly invested in the Raven Cycle and cannot wait to read Blue Lily, Lily Blue. I don't often read series because I find myself getting bored halfway through, but this is one that I'm more than happy to continue.
Thursday, November 6, 2014
Blood Sports by Eden Robinson | Book Review
Title: Blood Sports
Author: Eden Robinson
Publisher/Year: Mclelland & Stewart/2006
Series: No
Source: Purchased
Author: Eden Robinson
Publisher/Year: Mclelland & Stewart/2006
Series: No
Source: Purchased
Tom, a young man, hardly innocent, has been caught up over the years in Jeremy's world of drugs, extortion, and prostitutes, while Jeremy, vindictive, vicious, either protects Tom or uses him, but always controls him. Added to the mix is Paulie, a junkie two years clean and Tom's girlfriend, and also the mother of his daughter. This lethal triangle shifts when word gets out Tom has been talking to the police, and men from the past who have a lot to lose reappear. Suddenly Tom and Paulie are pawns in a much larger game, with everything at stake.
Thoughts and Reactions
I have to be honest, crime thrillers aren't my usual genre. I have a weak stomach, what can I say. No matter how well written a novel is I'll find myself skipping over parts of it I find too gruesome; it's the same reason I don't watch horror movies. I generally stick to contemporary for a reason. That having been said, every once in awhile I find myself picking up a crime novel, a novel that describes itself as gritty, and giving it a shot. I have yet to fall in love with one of these books, Blood Sports included.
Blood Sports fits squarely into its genre. It takes place on the Downtown East Side of Vancouver; one of the poorest areas of North America. Tom is living with his girlfriend and daughter in a small apartment, trying to leave his past behind, but it starts to catch up with him. He is kidnapped, tortured; it is all brutally described in detail. It may be a work of fiction, but none of it is entirely out of the realm of possible, making it that much more difficult to read.
Robinson's prose suits the genre and helps set a dark, dank and downright creepy tone throughout the novel. It is direct, never shying away from the more unsavoury details of whatever a character is going through, whether it be a drug overdose or torture. It is brutal and fitting. An interesting stylistic choice that I found to be quite effective was the way the story jumped around in time. It was jarring and on occasion it took me awhile to figure out where in time we were, but it added to the story's overall chaos and confusion. We are normally seeing the story through Tom's eyes and he is often unsure of what is happening; the jumps through time help bring that confusion to the reader.
The characterizations are brilliant and while I felt for Tom and his girlfriend Paulie; I could also clearly see how they ended up in the situation they were in. They made many poor choices, compounded by bad luck. That's not to say that I didn't want them to come out ahead in the end as they were complex characters who were clearly trying to build a better life, but it was also easy for me to see why that was so difficult for them. Jeremy Reiger, Tom's sociopathic cousin is one of the most disturbing, unfeeling characters I have come across in literature and not somebody I want to revisit anytime soon; I can only assume that was Robinson's goal while writing him into this novel and that she was successful at it.
I didn't love Blood Sports, but I didn't expect to. I found it to be more than a little unsettling and I do think that that's a sign of a successful thriller/murder mystery. I put down the book and felt so creeped out; there really was no reprieve to the tension. I think Robison wrote an excellent crime novel and I love that it was set in a Canadian city. It may not have been the book for me and I won't be picking up another thriller in the near future, but I would definitely recommend it to somebody who liked the genre and maybe, just maybe, has stronger nerves than me.
Saturday, November 1, 2014
On Reading the Classics
There was a time in my life when I would read the classics all the time. I loved them, or if I didn't love them, I could see the value in them and wanted to know why they gained the reputation they did. It's how I came across my love of Joseph Heller and realized after reading Anna Karenina that I never, ever wanted to read War & Peace. These books were my friends. They stuck with me for weeks as I lugged them from bus to bed to couch to appointment waiting room and occasionally even stuck with my thoughts.
Something changed between high school and now though and I'm not completely sure what it is. Sure I "got busy," but we're all busy and I was always busy; that shouldn't have prevented me from continuing to read these worthwhile novels. I'll cut myself some slack for the university years; I was reading a lot of books for school and when I was reading for pleasure I didn't necessarily want to think critically. That doesn't give me an excuse now.
I'm not going to lie; I have an absolute ton of classic novels bought for very little money, lining my shelves, completely untouched. I love reading YA (I wouldn't blog about it if I didn't), but why can't I read both? Granted these books are HUGE. The size is intimidating to say the least. I mean look at The Count of Monte Cristo!
See! See! (I'm sure you can also see that I need to work on my photography skills) But I shouldn't keep using that as an excuse, should I? I have these books sitting here; I SHOULD read them. Plus, they're classics for a reason... right?
Something changed between high school and now though and I'm not completely sure what it is. Sure I "got busy," but we're all busy and I was always busy; that shouldn't have prevented me from continuing to read these worthwhile novels. I'll cut myself some slack for the university years; I was reading a lot of books for school and when I was reading for pleasure I didn't necessarily want to think critically. That doesn't give me an excuse now.
I'm not going to lie; I have an absolute ton of classic novels bought for very little money, lining my shelves, completely untouched. I love reading YA (I wouldn't blog about it if I didn't), but why can't I read both? Granted these books are HUGE. The size is intimidating to say the least. I mean look at The Count of Monte Cristo!
|875 Pages of VERY TINY script!
I'm still nervous about the amount of time they're going to eat up. Time I could spend reading multitudes of other books, or watching movies or hanging out in my pyjamas with the boyfriend, but it could also be time well worth it. Time I spend immersed in another world, expanding my mind. One of the first up on my list is The Count of Monte Cristo, followed by The Lord of the Rings and maybe some Dostoevsky in the end. I can't guarantee I'll make it through, but it's worth a shot.
So friends, what do you think? Do you read the classics or did you at any point? Does anybody out there have any tips on follow through for me?
Thursday, October 16, 2014
Lock & Key by Sarah Dessen | Book Review
AUTHOR: Sarah Dessen
PUBLISHER/YEAR: Viking / 2008
SERIES: No
SOURCE: Purchased
Goodreads / Author's Website
There's a reason Sarah Dessen has such a huge following. She consistently writes engaging young-adult novels that touch on themes close to many people's hearts. Lock & Key is no exception. Ruby has been living on her own for months after her mother took off, but once social services finds out she goes to live with Cora, her estranged sister and Jamie, Cora's down to earth, family oriented husband.
Honestly, it took me awhile to get into this book and I don't think it was the story, but me. I don't think I was in the right mood for this particular book on this particular day. That having been said, Dessen constantly writes compelling, flawed characters that draw me in and make me want to keep reading. Ruby is so hurt and this story is really about her and learning how to trust and reconcile her old life with her new one. I felt for her despite her flaws and her occasional obvious obliviousness.
Of course, there's also the boy next door. Nate, the hot swimmer who seems to have a perfect life, but as the two get closer and Ruby learns to open up, it becomes obvious that not all is what it seems. I found Nate's story to be almost more compelling than Ruby's. He was such a sympathetic character, always putting others before himself. I kind of wanted a glimpse into his head. I felt for him and wanted to know more.
Being a comfort read, the plot was fairly predictable,but sometimes that's okay. You know what you're getting when you read a Dessen novel and you start it because you know you'll like it in the end despite it's predictability.
Friday, October 10, 2014
On Balance and Life
You guys, I've been out of the game for ages now. In fact, even now I'm not convinced that I'll be able to make a blog and life work. Don't get me wrong, I love the blogging community and have been reading reviews periodically even if I haven't been commenting. I just don't know how to make blogging work with life. It's like a full time job in itself and over the past year I've found that I've barely been reading let alone writing.
I'm going to try to get back in the game a little. Maybe posting here and there. I've got a backlog of books to read and I love sharing my thoughts and hearing what everybody else thinks. I don't know if it's going to work, but it's worth a shot, no?
How do you all make it work and prevent these year long breaks?
I'm going to try to get back in the game a little. Maybe posting here and there. I've got a backlog of books to read and I love sharing my thoughts and hearing what everybody else thinks. I don't know if it's going to work, but it's worth a shot, no?
How do you all make it work and prevent these year long breaks?
Thursday, November 7, 2013
Bellman & Black: A Ghost Story by Diane Setterfield | Book Review
AUTHOR: Diane Setterfield
PUBLISHER/YEAR: Atria Books / October 2013
SERIES: No
SOURCE: Received for Review via NetGalley
Goodreads / Author's Website
Recently I've been trying to branch out from my typical YA fare. It may seem a little nuts since I haven't been involved with the YA community for that long and I have so much catching up to do, but I've been missing my literary fiction. With that in mind I picked up Bellman & Black; Diane Setterfield's second novel. Now I haven't read The Thirteenth Tale, but I've heard some really good things about it so I was kind of looking forward to Bellman & Black just based on author reputation. I just didn't end up loving it as much as I thought I would.
What originally drew me to the novel was the premise more than anything else. It's described as a ghost story. William Bellman accidentally kills a rook when he's eleven years old, an incident that supposedly has a profound impact on his life. We jump ahead to when he is a young adult, leading a very happy life. He marries a beautiful woman, has healthy children and is amazingly successful in his business. However, the people he loves are slowly taken from him until it all ends in tragedy. A mysterious man dressed all in black has been at each funeral and as the deaths get closer to Bellman, the man offers him a compromise to save his favourite child, but it's a deal he can't fully remember.
That set up sounds kind of fantastic. It's a ghost story, a man haunted by death, but I just didn't think it panned out like I thought it would. I was expecting well a ghost or at least a little bit of creep factor. I didn't get any of that at all. Honestly, I felt like these life changing events left Bellman nearly completely unmarred. I would have loved just a little more humanity from him. The beginning is strong. Setterfield manages to build a sense of foreboding withing the first few pages. She has a very descriptive writing style that worked so well in setting tone. Like I figured something was going to happen after the innocent rook is killed. As the deaths started piling up I was definitely creeped out, but that's where the book lost me.
While the tone and style worked, William never seemed like a fully fleshed out character. More than anything else he felt like an allegorical character more than anything else. He was only there to prove a moral point; he was a protagonist in a three hundred plus page book and it just didn't work for me. He was distant and lacked a human element. He was so focused on his work and making things run smoothly that he missed the real parts of life, the play and the grief. While I feel like it worked in getting across the overall message of the book I didn't want to read about a theme, I prefer reading about a person. It was hard to invest in him when he was invested in so little.
I also couldn't really get a feel for secondary characters. Bellman couldn't connect to them and therefore I as a reader couldn't. Some of them seemed to have interesting stories, but it's hard to say when we learn so little about them. Overall I would have loved to see some more character development throughout the novel.
I feel like the point of the book was that death comes for everybody and we need to take time out to appreciate life and grieve for the ones we lost; things that Bellman never did. Here's the thing though; I feel like that's a pretty well used/loved theme and I don't think this is the best example of it. There was a total disconnect between the tone and the plot. The basic plot was just so well known, man invests more in money than he does in life and there wasn't anything new in it.
I loved Setterfield's overall style. I loved the eeriness and have no complaints about tone or style. I would still love to read The Thirteenth Tale because writing wise Bellman & Black totally worked for me. I wish I could say I connected to this particular story more, but it left me flat. Well trodden themes and characters that I couldn't feel for made reading this particular book feel like a chore. However, I did gain a new appreciation for Setterfield's style and look forward to trying another book of hers in the future.
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Cynthia is responsible for the day to day operations and staff management at the GRN. She is primarily responsible for foundation fundraising, and also works to elevate regional issues to a national level, and monitors federal agency action affecting coastal and marine endangered species in Gulf states.
Cynthia received her B.A. from the University of Guelph, Ontario, Canada, her law degree from the University of Mississippi in 1983, and her Masters of Law in Law and Marine Affairs from the University of Washington in 1992.
How is Louisiana addressing its dropout problem?
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How does Louisiana determine if someone is a danger to themselves or others?»»» View all Topics!

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Sprague Rappaport Stethescope
Home > Diagnostics > Stethoscopes > Sprague Rappaport Stethescope
Sku: 46608
Designed to detect the entire range of heart and chest auscultation. Features a proprietary valve mechanism that eliminates acoustic leakage, a threaded, chrome-plated zinc chestpiece drum that permits the use of five interchangeable chestpiece fittings, adjustable chrome-plated brass binaurals and a heavy-walled double tubing configuration that blocks out extraneous sounds.
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- Cooking Time:
- Servings: Serves 2
- Preparation Time:
- 2 slices Pepperidge Farm* 9 grain natural Whole Grain Bread
- 1/2 tsp.dried oregano leaves,crushed
- 2 medium plum tomatoes,thinly sliced
- 2 oz. fresh mozzarella cheese,cut up
- 6 fresh basil leaves,thinly shredded
- Spray top of each bread slice with vegetable cooking spray, and sprinkle with oregano.
- Heat 10" nonstick skillet 1 min.
- Add bread, oregano-side down, and cook until browned.
- Turn over.
- Top with tomatoes and cheese.
- Cover and heat until cheese softens.
- Sprinkle with basil
NotesPizza from a slice of Bread !!!
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2008 Honda Fit • 4 cylinder 2WD Automatic • 45,000 miles
My engine stalled on the freeway, completely lost power and coasted to the side, a couple days before that it stalled while driving around neighborhood, mechanics rebooted computer, no problem until about 6 months ago idling rough and now stalling in the morning when engine called, pulled in reverse and than stalling. Mechanic couldn't catch the problem when I took it in. European recall and north American recall with engine spring could be the problem
February 17, 2011.
February 17, 2011.
I don't know about the recall. What spring are you refering to?
May 3, 2011.
May 3, 2011.
If i took out my 91 toyota carolla engine what other cars would it be compatible with?
4 answers • 1991 Toyota Corolla
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1992 Isuzu Rodeo 3.1 V6 mileage: 135,000. I am wanting to replace the engine in my Isuzu Rodeo. I have seen many different types of redo's but I would like to put a 305 V8 and change ...
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When Sparks Fly: Teatro ZinZanni's Electrifying New Dinner Show
* Additional fees apply.
The last date listed for When Sparks Fly was Sunday August 31, 2014 / 5:30pm.
Currently at Teatro ZinZanni
Teatro ZinZanni's Big Top Rock: Curious Circus -- A Rock 'n' Roll Circus for Families
- Full Price:
- $19.00
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- $9.50
It's a jam-packed morning of family fun when Mother of Invention's Exhibition of Ideas and Invent...Learn More
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Eat before you come. There's only popcorn and donuts for sale.Teatro ZinZanni's Big Top Rock: Curious Circus info • Nov 10 2014 star this tip starred
Try to sit close to the center. More expensive, but worth it.When Sparks Fly info • Aug 26 2014 star this tip starred
Reviews & Ratings
Featured review from csinape
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Program great, but experience bad--Worst seats in the house that should not be given to anyone except a contortionist. Back to the music stage where some performances were & could not see them--had to turn left and bend forward to see anything on center stage & try not to block person next to me from seeing, & light shined in my eyes preventing me from seeing aerial acts!!
Eight of us were packed in the booth--noticed some booths with better views had 4 people! Realize Groupon people pay a little less, but this was bad.
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Wonderful show, BUT They added surcharge onto our bill of $25.86, which we were very surprised about and expressed to our waitress, which she then voiced that we had only paid half of what the price was so they added the extra charge to pay for...continued
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Seating face opposite of the stage.
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Marvelous evening! Good meal, nice service, fabulous show.
Menu and beverage selections are subject to change without notice.
Each course is served at your table and service is completely intertwined with the show.
A full selection of cocktails, fine wine, domestic and imported beer, champagne, cognac and after-dinner drinks is available in the lounge and at your table. The Lounge is open for drinks and shopping one hour before show time.
Teatro ZinZanni generally recommends the show to guests age 13 and older. It is a very long evening with a sophisticated menu that is not necessarily designed for a child's palate. However, there is no age restriction, so parents should use their best judgment.


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Are you Holbrook E Kohrt?Claim your profile
Publications (69)417.62 Total impact
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ABSTRACT: Blockade of the immune checkpoint programmed death receptor ligand-1 (PD-L1)/PD-1 pathway has well-established clinical activity across many tumor types. PD-L1 protein expression by immunohistochemistry (IHC) is emerging as a predictive biomarker of response to these therapies. Here, we examine PD-L1 expression in a thymic epithelial tumor (TET) tissue microarray (TMA). The TMA contained 69 TETs and 17 thymic controls, with each case represented by triplicate cores. The TMA was stained with rabbit monoclonal antibody (clone 15, Sino Biological) to human PD-L1. PD-L1 staining was scored based on intensity as follows: 0=none, 1=equivocal/uninterpretable, 2=weak, and 3=intermediate-strong. Those cases with all cores scoring 3 in the epithelial component were categorized as PD-L1 and the remaining as PD-L1. D-L1 scores were more frequent in TETs than controls (68.1% vs. 17.6%, p=0.0036). PD-L1 scores and histology were significantly correlated, with higher intensity staining in WHO B2/B3/C TETs. Only 14.8% of TETs had PD-L1 staining of associated lymphocytes. In an adjusted analysis (age/gender), PD-L1 TETs had a significantly worse overall survival (HR 5.40, 95% CI 1.13-25.89, p=0.035) and a trend for worse event-free survival (HR 2.94, 95% CI 0.94-9.24, p=0.064). PD-L1 expression was present in all cases of TETs within the epithelial component but only in a minority in the lymphocytic component. TETs stained more intensely for PD-L1 than controls, and PD-L1 TETs were associated with more aggressive histology and worse prognosis. This study lends rationale to a clinical trial with anti-PD1/PD-L1 therapy in this rare tumor type.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 11/2014; · 4.55 Impact Factor
Article: Treatment of 4T1 Metastatic Breast Cancer with Combined Hypofractionated Irradiation and Autologous T-Cell Infusion.[Show abstract] [Hide abstract]
ABSTRACT: The goal of this study was to determine whether a combination of local tumor irradiation and autologous T-cell transplantation can effectively treat metastatic 4T1 breast cancer in mice. BALB/c mice were injected subcutaneously with luciferase-labeled 4T1 breast tumor cells and allowed to grow for 21 days, at which time metastases appeared in the lungs. Primary tumors were treated at that time with 3 daily fractions of 20 Gy of radiation each. Although this approach could eradicate primary tumors, tumors in the lungs grew progressively. We attempted to improve efficacy of the radiation by adding autologous T-cell infusions. Accordingly, T cells were purified from the spleens of tumor-bearing mice after completion of irradiation and cryopreserved. Cyclophosphamide was administered thereafter to induce lymphodepletion, followed by T-cell infusion. Although the addition of cyclophosphamide to irradiation did not improve survival or reduce tumor progression, the combination of radiation, cyclophosphamide and autologous T-cell infusion induced durable remissions and markedly improved survival. We conclude that the combination of radiation and autologous T-cell infusion is an effective treatment for metastatic 4T1 breast cancer.Radiation research. 07/2014;
Article: Variability in CRP, regulatory T cells and effector T cells over time in gynaecological cancer patients: a study of potential oscillatory behaviour and correlations.[Show abstract] [Hide abstract]
ABSTRACT: The inflammatory marker, C reactive protein has been proposed to also be a biomarker for adaptive immune responses in cancer patients with a possible application in time based chemotherapy. Fluxes in serum CRP levels were suggested to be indicative of a cyclical process in which, immune activation is followed by auto-regulating immune suppression. The applicability of CRP as a biomarker for regulatory or effector T cells was therefore investigated in a cohort of patients with gynaecological malignancies.Journal of Translational Medicine 06/2014; 12(1):179. · 3.46 Impact Factor
Article: Child abuse, disruptive behavior disorders, depression, and salivary cortisol levels among institutionalized and community-residing boys in Mongolia.[Show abstract] [Hide abstract]
ABSTRACT: Hypothalamic-pituitary-adrenal (HPA) axis activity is related to childhood disruptive behavior disorders and to exposure to abuse and neglect. This study explores the relationship of diurnal salivary cortisol levels with oppositional defiant disorder (ODD) and caregiver attitudes toward physical punishment among boys in Mongolia.Asia-Pacific Psychiatry 06/2014; · 0.47 Impact Factor
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ABSTRACT: Treatment with cetuximab, an EGFR-targeting IgG1 mAb, results in beneficial, yet limited, clinical improvement for patients with head and neck (HN) cancer as well as colorectal cancer (CRC) patients with WT KRAS tumors. Antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells contributes to the efficacy of cetuximab. The costimulatory molecule CD137 (4-1BB) is expressed following NK and memory T cell activation. We found that isolated human NK cells substantially increased expression of CD137 when exposed to cetuximab-coated, EGFR-expressing HN and CRC cell lines. Furthermore, activation of CD137 with an agonistic mAb enhanced NK cell degranulation and cytotoxicity. In multiple murine xenograft models, including EGFR-expressing cancer cells, HN cells, and KRAS-WT and KRAS-mutant CRC, combined cetuximab and anti-CD137 mAb administration was synergistic and led to complete tumor resolution and prolonged survival, which was dependent on the presence of NK cells. In patients receiving cetuximab, the level of CD137 on circulating and intratumoral NK cells was dependent on postcetuximab time and host FcyRIIIa polymorphism. Interestingly, the increase in CD137-expressing NK cells directly correlated to an increase in EGFR-specific CD8+ T cells. These results support development of a sequential antibody approach against EGFR-expressing malignancies that first targets the tumor and then the host immune system.The Journal of clinical investigation. 05/2014;
- [Show abstract] [Hide abstract]
ABSTRACT: Immune cell infiltration in the tumor microenvironment is of prognostic and therapeutic import. These immune cell subsets can be heterogeneous and are composed of mature antigen-presenting cells, helper and effector cytotoxic T cells, toleragenic dendritic cells, tumor-associated macrophages, and regulatory T cells, among other cell types. With the development of novel drugs that target the immune system rather than the cancer cells, the tumor immune microenvironment is not only prognostic for overall patient outcome, but also predictive for likelihood of response to these immune-targeted therapies. Such therapies aim to reverse the cancer immunotolerance and trigger an effective antitumor immune response. Two major families of immunostimulatory drugs are currently in clinical development: pattern recognition receptor agonists (PRRago) and immunostimulatory monoclonal antibodies (ISmAb). Despite their immune-targeted design, these agents have so far been developed clinically as if they were typical anticancer drugs. Here, we review the limitations of this conventional approach, specifically addressing the shortcomings of the usual schedules of intravenous infusions every 2 or 3 weeks. If the new modalities of immunotherapy target specific immune cells within the tumor microenvironment, it might be preferable to deliver them locally into the tumor rather than systemically. There is preclinical and clinical evidence that a therapeutic systemic antitumor immune response can be generated upon intratumoral immunomodulation. Moreover, preclinical results have shown that therapeutic synergy can be obtained by combining PRRagos and ISmAbs to the local tumor site. Clin Cancer Res; 20(7); 1747-56. ©2014 AACR.Clinical Cancer Research 04/2014; 20(7):1747-56. · 7.84 Impact Factor
- Blood 03/2014; 123(12):1957-60. · 9.78 Impact Factor
Article: TLI-ATG Conditioning and Allogeneic Transplantation for Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms.[Show abstract] [Hide abstract]
ABSTRACT: Allogeneic hematopoietic cell transplantation (allo HCT) is the only curative therapy for the Myelodysplastic Syndromes (MDS) and Myeloproliferative Neoplasms (MPN), but treatment related toxicity has been a barrier to its more widespread use. The non-myeloablative regimen of Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) permits the establishment of donor hematopoiesis necessary for the graft versus malignancy (GVM) effect and is protective against acute Graft versus Host Disease (aGVHD) but has minimal direct cytotoxicity against myeloid diseases. We explored the use of TLI-ATG conditioning to treat 61 patients with allo HCT for MDS (n= 32), therapy-related myeloid neoplasms (n=15), MPN (n=9) and CMML (n=5). The median age of all patients was 63 years (range 50-73). The cumulative incidence of aGVHD Grades II-IV was 14% (95% CI 4-23%) and Grades III-IV 4% (0-9%) and did not differ between patients that received allografts from related or unrelated donors. The cumulative incidence of non-relapse mortality (NRM) at 100 days, 12 months, and 36 months was 0%, 7%, and 11%. Overall survival (OS) and progression-free survival (PFS) were 41% (29-53%) and 35% (23-48%) respectively. The safety and tolerability of TLI-ATG, as exemplified by its low non-relapse mortality, provides a foundation for further risk-adapted or prophylactic interventions to prevent disease progression.Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 03/2014; · 3.15 Impact Factor
Article: Donor hematopoiesis in mice following total lymphoid irradiation requires host T regulatory cells for durable engraftment.[Show abstract] [Hide abstract]
ABSTRACT: Total lymphoid irradiation (TLI) with anti-thymocyte globulin (ATG) is a unique regimen that prepares recipients for allogeneic hematopoietic cell transplantation (HCT) by targeting lymph nodes, while sparing large areas of the bone marrow (BM). TLI is reported to increase the frequency of regulatory CD4(+)CD25(+)FoxP3(+) T cells (Treg) relative to conventional T cells. Here, barriers to hematopoietic stem cell (HSC) engraftment following this non-myeloablative conditioning were evaluated. TLI/ATG resulted in profound lymphoablation but endogenous host HSC remained. Initial donor HSC engraftment occurred only in radiation exposed marrow sites, but gradually distributed to BM outside the radiation field. Sustained donor engraftment required host lymphoid cells since lymphocyte deficient Rag2γc(-/-) recipients had unstable engraftment compared to wild-type. TLI/ATG treated wild-type recipients had increased proportions of Treg which was associated with increased HSC frequency and proliferation. In contrast, Rag2γc(-/-) recipients that lack Treg did not. Adoptive transfer of Treg into Rag2γc(-/-) recipients resulted in increased cell cycling of endogenous HSC. Thus, we hypothesize that Treg influence donor engraftment post-TLI/ATG by increasing HSC cell cycling, thereby promoting exit of host HSC from the marrow niche. Our study highlights the unique dynamics of donor hematopoiesis following TLI/ATG, and the effect of Treg on HSC activity.Blood 03/2014; · 9.78 Impact Factor
Article: Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies.[Show abstract] [Hide abstract]
ABSTRACT: Natural killer (NK) cells mediate anti-lymphoma activity by spontaneous cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC) when triggered by rituximab, an anti-CD20 monoclonal antibody (mAb) used to treat patients with B cell lymphomas. The balance of inhibitory and activating signals determines the magnitude of NK cell's efficacy by spontaneous cytoxicity. Here, using a killer cell immunoglobulin-like receptor (KIR) transgenic murine model, we show that blockade of the interface of inhibitory KIRs with MHC class I antigens on lymphoma by anti-KIR antibodies prevents a tolerogenic interaction and augments NK cell spontaneous cytotoxicity. In combination with anti-CD20 mAbs, anti-KIR treatment induces enhanced NK cell-mediated, rituximab-dependent cytotoxicity against lymphoma in vitro and in vivo in KIR transgenic and syngeneic murine lymphoma models. These results support a therapeutic strategy of combination, rituximab and KIR blockade through lirilumab, illustrating the potential efficacy of combining a tumor targeting therapy with an NK cell agonist thus stimulating the post-rituximab anti-lymphoma immune response.Blood 12/2013; · 9.78 Impact Factor
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ABSTRACT: Systemic administration of the checkpoint blockade antibody anti-CTLA4 results in severe auto-immune toxicity, limiting its clinical efficacy. Fransen and colleagues show here that peri-tumoral delivery of low doses of this immunomodulatory drug can trigger a systemic anti-tumor immune response while preventing the toxicity against other organs.Clinical Cancer Research 08/2013; · 7.84 Impact Factor
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ABSTRACT: The aryl hydrocarbon receptor (AhR) has become increasingly recognized for its role in the differentiation and activity of immune cell subsets; however, its role in regulating the activity of natural killer (NK) cells has not been described. Here, we show that AhR expression is induced in murine NK cells upon cytokine stimulation. We show that in the absence of AhR, NK cells have reduced cytolytic activity and reduced capacity to control RMA-S tumor formation in vivo, despite having normal development and maturation markers. Although AhR was first identified to bind the xenobiotic compound dioxin, AhR is now known to bind a variety of natural exogenous (e.g., dietary) and endogenous ligands. We show that activation of AhR with an endogenous tryptophan derivative, 6-formylindolo[3,2-b]carbazole, potentiates NK cell IFN-γ production and cytolytic activity. Further, administration of 6-formylindolo[3,2-b]carbazole in vivo enhances NK cell control of tumors in an NK cell- and AhR-dependent manner. Finally, similar effects on NK cell potency occur with AhR dietary ligands, potentially explaining the numerous associations that have been observed in the past between diet and NK cell function. Our studies introduce AhR as another regulator of NK cell activity in vivo.Proceedings of the National Academy of Sciences 07/2013; · 9.81 Impact Factor
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ABSTRACT: Activation of TLR9 by direct injection of unmethylated CpG nucleotides into a tumor can induce a therapeutic immune response; however, Tregs eventually inhibit the antitumor immune response and thereby limit the power of cancer immunotherapies. In tumor-bearing mice, we found that Tregs within the tumor preferentially express the cell surface markers CTLA-4 and OX40. We show that intratumoral coinjection of anti–CTLA-4 and anti-OX40 together with CpG depleted tumor-infiltrating Tregs. This in situ immunomodulation, which was performed with low doses of antibodies in a single tumor, generated a systemic antitumor immune response that eradicated disseminated disease in mice. Further, this treatment modality was effective against established CNS lymphoma with leptomeningeal metastases, sites that are usually considered to be tumor cell sanctuaries in the context of conventional systemic therapy. These results demonstrate that antitumor immune effectors elicited by local immunomodulation can eradicate tumor cells at distant sites. We propose that, rather than using mAbs to target cancer cells systemically, mAbs could be used to target the tumor infiltrative immune cells locally, thereby eliciting a systemic immune response.Journal of Clinical Investigation 05/2013; In Press. · 12.81 Impact Factor
Article: Identification of gene microarray expression profiles in patients with chronic graft-versus-host disease following allogeneic hematopoietic cell transplantation.[Show abstract] [Hide abstract]
ABSTRACT: Chronic graft-versus-host disease (GVHD) results in significant morbidity and mortality, limiting the benefit of allogeneic hematopoietic cell transplantation (HCT). Peripheral blood gene expression profiling of the donor immune repertoire following HCT may provide associated genes and pathways thereby improving the pathophysiologic understanding of chronic GVHD. We profiled 70 patients and identified candidate genes that provided mechanistic insight in the biologic pathways that underlie chronic GVHD. Our data revealed that the dominant gene signature in patients with chronic GVHD represented compensatory responses that control inflammation and included the interleukin-1 decoy receptor, IL-1 receptor type II, and genes that were profibrotic and associated with the IL-4, IL-6 and IL-10 signaling pathways. In addition, we identified three genes that were important regulators of extracellular matrix. Validation of this discovery phase study will determine if the identified genes have diagnostic, prognostic or therapeutic implications.Clinical Immunology 05/2013; 148(1):124-135. · 3.77 Impact Factor
Article: High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells.[Show abstract] [Hide abstract]
ABSTRACT: Defects in T cell function in cancer patients might influence their capacity to mount efficient anti-tumor immune responses. Here we identified highly reduced IL-4-, IL-10- and IL-21-induced phosphorylation of STAT6 and STAT3 in tumor infiltrating T cells (TILs) in follicular lymphoma (FL) tumors, contrasting other non-Hodgkin lymphoma TILs. By combining phospho-protein specific flow cytometry with several T cell markers, we identified that CD4(+)CD45RO(+)CD62L(-) FL TILs were largely non-responsive to cytokines, in contrast to the corresponding autologous peripheral blood subset. We observed differential expression of the inhibitory receptor PD-1 in FL TILs and peripheral blood T cells. Furthermore, CD4(+)PD(-)1(hi) FL TILs, containing T(FH) and non-T(FH) cells, had lost their cytokine responsiveness, whereas PD-1(-) TILs had normal cytokine signaling. However, this phenomenon was not tumor-specific, since tonsil T cells were similar to FL TILs. FL tumor cells were negative for PD-1 ligands, but PD-L1(+) histiocytes were found within the T-cell rich zone of the neoplastic follicles. Disruption of the microenvironment and in vitro culture of FL TILs could restore cytokine signaling in the PD-1(hi) subset. Since FL TILs in vivo likely receive suppressive signals through PD-1, this provides a rationale for testing PD-1 Ab in combination with immunotherapy in FL patients.Blood 01/2013; · 9.78 Impact Factor
Dataset: CD8+CD44(hi) but not CD4+CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD
Article: Cancer Vaccines and T Cell Therapy.[Show abstract] [Hide abstract]
ABSTRACT: ▪▪▪.Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 10/2012; · 3.15 Impact Factor
Article: CD137 is expressed in follicular dendritic cell tumors and in classical Hodgkin and T-cell lymphomas: diagnostic and therapeutic implications.[Show abstract] [Hide abstract]
ABSTRACT: CD137 (also known as 4-1BB and TNFRSF9) is a member of the tumor necrosis factor receptor superfamily. Originally identified as a costimulatory molecule expressed by activated T cells and NK cells, CD137 is also expressed by follicular dendritic cells, monocytes, mast cells, granulocytes, and endothelial cells. Anti-CD137 immunotherapy has recently shown promise as a treatment for solid tumors and lymphoid malignancies in preclinical models. We defined the expression of CD137 protein in both normal and neoplastic hematolymphoid tissue. CD137 protein is expressed by follicular dendritic cells in the germinal center and scattered paracortical T cells, but not by normal germinal-center B cells, bone marrow progenitor cells, or maturing thymocytes. CD137 protein is expressed by a select group of hematolymphoid tumors, including classical Hodgkin lymphoma, T-cell and NK/T-cell lymphomas, and follicular dendritic cells neoplasms. CD137 is a novel diagnostic marker of these tumors and suggests a possible target for tumor-directed antibody therapy.American Journal Of Pathology 09/2012; 181(3):795-803. · 4.60 Impact Factor
Article: Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody.[Show abstract] [Hide abstract]
ABSTRACT: Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.Oncoimmunology. 09/2012; 1(6):957-958.
Article: The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses.[Show abstract] [Hide abstract]
ABSTRACT: Infiltration of specialized immune cells regulates the growth and survival of neoplasia. Here, in a survey of public whole genome expression datasets we found that the gene for chemerin, a widely expressed endogenous chemoattractant protein, is down-regulated in melanoma as well as other human tumors. Moreover, high chemerin messenger RNA expression in tumors correlated with improved outcome in human melanoma. In experiments using the B16 transplantable mouse melanoma, tumor-expressed chemerin inhibited in vivo tumor growth without altering in vitro proliferation. Growth inhibition was associated with an altered profile of tumor-infiltrating cells with an increase in natural killer (NK) cells and a relative reduction in myeloid-derived suppressor cells and putative immune inhibitory plasmacytoid dendritic cells. Tumor inhibition required host expression of CMKLR1 (chemokine-like receptor 1), the chemoattractant receptor for chemerin, and was abrogated by NK cell depletion. Intratumoral injection of chemerin also inhibited tumor growth, suggesting the potential for therapeutic application. These results show that chemerin, whether expressed by tumor cells or within the tumor environment, can recruit host immune defenses that inhibit tumorigenesis and suggest that down-regulation of chemerin may be an important mechanism of tumor immune evasion.Journal of Experimental Medicine 07/2012; 209(8):1427-35. · 13.21 Impact Factor
Top Journals
Stanford University
Palo Alto, California, United States
- • Division of Hematology
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- • Department of Surgery
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Centre Hospitalier Universitaire de RennesRoazhon, Brittany, France
University of California, San Francisco
San Francisco, CA, United States
- Division of Hospital Medicine
Stanford Medicine
Stanford, California, United States
- • Department of Medicine
- • Division of Hematology
Indiana Blood and Marrow TransplantationIndianapolis, Indiana, United States


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Books » Category » AU, NZ & South Pacific Books » New Zealand
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By Barraud, Ned; Candler, Gillian
Under the Ocean introduces young children to the creatures that live in the seas around New Zealand. The book describes different habitats: underwater reefs, the sea floor, the open ocean and the deep ocean. Animals featured in the fact pages include octopus and squid, sharks and ...
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By Challinor, Deborah
1830s Sydney Town - with its bar brawls, blackmail, friendship, romance, tattoos, gin and much more - is brought vividly to life as fiesty prostitute Friday, naive seamstress Harrie and cunning thief Sarah try to make their way as transported convict women. 1831: Assigned to a go ...
By Williams, Peter
n his time as a criminal defence lawyer in the New Zealand courts, Peter Williams QC has seen it all. From the days when abortion, homosexuality and even telling fortunes could see a person hauled before the courts, to sensational cases of wrongful imprisonment and police corrupt ...
By McMillan, Dawn; Illustrated by Kinnaird, Ross
A strong wind, a loose peg, and Doctor Grundy's Undies are off for a ride! Will his underwear survive?"--Back cover.
By Smith, Craig; Illustrated by Tulloch, Scott
Square Eyes the panda likes to watch television and not play outside or do any exercise so his friends sing him a song to get him moving.
By Kirwan, John; With Bell, Elliot; Louden-Bell, Kirsty
'I'm a dad and I'm scared.' Charting John Kirwan's experiences as a father, and incorporating voices of young people today, Stand By Me examines issues around teenage mental health, with a focus on depression and anxiety. It is intended as a useful guide for parents, caregivers a ...
Edited by Green, Paula; Illustrated by Cooper, Jenny
The best New Zealand poems for children, collected by star New Zealand poet Paula Green and illustrated inventively by Jenny Cooper. This exciting collection is truly a must-have for every home, school and library. Bursting with wonderful poems that will make you laugh, cry, nod ...
By Llewelyn, Christopher; Illustrated by Tulloch, Scott
After a long day's work at the zoo, the animals all head back to their respective homes and families, making their way back to the work and navigating the city the following morning, just like mums and dads do! Some ride public transport, some take a jog, some hitch a ride and to ...
By McCauley, Debbie; Translated by Waaka, Tamati
Tells the story of a little blue penguin who was covered in oil as a result of the oil spill from the Rena shipwreck. Describes his rescue, the treatment he had at the Te Maunga Oiled Wildlife Response Unit and his release back into the wild. Sidebars provide more information abo ...
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Bahco Raker Tooth Hard Point Bow Saw Blade 24" / 607mm For Green Wood
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Fugitive lip biter arrested in California
Nov 6, 2014
Jonathan E. Benedict
Oct 30, 2014
Darrell W. Cook
Oct 2, 2014
Michael Polchies
Sep 25, 2014
Home » News » Crime
Woman sentenced to prison for Portsmouth Market Basket robbery
Julia Marie Konchek, 22, pleaded guilty to a felony robbery charge in Rockingham County Superior Court, admitting that she snatched a woman's Fendi purse inside the Woodbury Avenue store on Feb. 19.
Konchek has been held at the county jail since her arrest. Her 111 days behind bars will count toward her state prison sentence.
Last week, a judge denied a request by prosecutors for an extension to seek an indictment against Roy.
The state is generally required to obtain an indictment within 90 days after a person is arrested unless it wins permission from a judge for more time to work on a case.
No second request has been filed.
Konchek and Roy were arrested by Portsmouth police shortly after the robbery in February.
Roy's lawyer, Brian Lavallee, had argued against the state getting any kind of extension to seek an indictment against his client, and suggested they had no evidence to support the charge.
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Police say hit-and-run driver was observed tossing beer cans from carREADER COMMENTS: 0
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Pipes and plans: A chance to show up Mass.
Manchester school exec contract squeaks by
Pipes and plans: A chance to show up Mass.
Manchester school exec contract squeaks by
Your Turn, NH -- Mike Moffett: Republicans can win in 2016 with Kasich at the top of the ticket
- Whom do you think bears the brunt of the blame for the mayhem this weekend in Keene?
- KSC students
- 37%
- KSC administration
- 2%
- Police
- 6%
- Visitors from out of town
- 18%
- A combination of any/all of the above
- 37%
- Total Votes: 2483


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Fantasia Painter, an excellent photo editing app for Windows Phone that we reviewed nearly two years ago, will continue development after its main creator took a long hiatus from the app.
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Welcome to the Virginia Society of Association Executives (VSAE) website. VSAE is the only association in Virginia that serves the state's association management industry. We focus our resources on the professional development needs of our members by providing information, education and ideas to assist association executives in the profession.
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Phone: 804-747-4971 Fax: 804-747-5022Email: firstname.lastname@example.com our staff


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Please email email@example.com for current class times, availability, and pricing. We are experiencing a very high volume of calls right now. Please be patient and leave a message or send an email. We will get back to you as soon as we can, usually within a week. – Mr. Simon
Congratulations to Tingting Bi, a longtime student and now Editor in Chief of the Mission San Jose High School Smoke Signal student newspaper. Congratulations also to all our College Counseling students who gained admittance to top schools including Berkeley, UCLA, NYU, RPI, Carnegie Mellon, Boston, and Washington.
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Resources and Publications
Resource and Publication
Policymakers should do more to spur data-driven innovation in both the public and private sectors.
Advancing globally, cost-competitive clean energy solutions to climate change requires a shift from a...
We need an "innovation economics" approach to the budget that spurs growth through increased investments,...
The EU-U.S. T-TIP Agreement will only be fully successful if it fully maximizes innovation.
A thorough analysis of capital investment over the past three decades uncovers several troubling trends.
The use of localization barriers to trade, by numerous countries, threatens the global economy.
Congress needs to reauthorize the Federal Helium Program now in order to avoid idling a valuable public...
Neo-Luddites are once again blaming technology for job loss but the evidence shows they are wrong.
An infographic illustrating how to fund next-generation clean energy breakthroughs.
ITIF explains the difference between competitiveness, innovation and productivity in this policy memo.
A discussion of why Trade Promotion Authority (TPA) is a vital component of U.S. trade policy.
In its new report, Google details the improved methods it is using to combat piracy.
Criticisms of a leaked IP chapter for the TPP are unfounded and overblown.
The Trans-Pacific Partnership needs to be a "gold standard" agreement to be truly effective.
We should focus on promoting the positive aspects of Big Data.
The drastic economic cost of across-the-board deep decarbonization can be avoided.
This accompanying blog summarizes ITIF's comments to the State of New York regarding their BitLicenses.
GMOs, Neonicotinoids, and Aldo Leopold's Land Ethic: The Fish & Wildlife Service Brings a "Whole Foods" Approach to Wildlife While Shooting Itself in Our Foot
U.S. Fish & Wildlife Service betrays it's conservationist legacy by adopting scientifically indefensible bans on modern farming techniques.
Portions of the EU's proposed General Data Protection Regulation (GDPR) would introduce inefficiencies into the process of conducting medical research.
New paper finds that STEM immigrants increase wages for workers of all skill levels.
Stephen Ezell presented on Mexico's Innovation Ecosystem at the Wilson Center.
Val Giddings discussed the importance of continued agricultural innovation at the 2014 North Carolina...
Rob Atkinson discussed the impact of ICT growth at the "Building Blocks of the Ubiquitous Digital Single...
Rob Atkinson presented on "How the Cloud Can Drive Economic Growth" to Canada's Digital Policy...
ITIF co-hosted events in London and Brussels to assess the roots of the EU's productivity and ICT adoption...
Doug Brake argued the case for Communications Act rewrite at the Congressional Internet Caucus Advisory...
Daniel Castro will present on the panel "Data and Privacy: Identification, De-Identification, and Re-...
Daniel Castro will speak at the Association of Public Data Users 2014 Annual Conference.
Daniel Castro will participate in the American Bar Association webinar "Big Data and Privacy Frameworks:...
Stephen Ezell presented at the Swedish Network for Innovation and Technology Transfer Support's Innovation by...
ITIF Submits Comments on House Energy and Commerce Whitepaper on Competition Policy in Communications
ITIF submitted comments with the House Committee on Energy and Commerce on competition policy and broadband...
Matthew Stepp testifies before the United States House Natural Resources Committee Subcommittee on Energy and...
Undue regulation would hamper public benefit of patient-generated health data.
Senate testimony argues that limiting collection of geo-location data by third parties for commercial use...
ITIF amicus brief asks U.S. Supreme Court to clarify the treatment of WiFi under the Wiretap Act.
To drive growth and innovation, Washington needs to address, three deficits, not just the budget deficit.
Communications Act Update provides opportunity to reform spectrum policy and unlock capacity to fuel wireless...
The FTC should avoid unnecessarily regulating predictive analytics and the underlying data. Instead, it...
The U.S. decision to forgo oversight of Internet governance has inherent risks.
Data has the potential to improve economic growth and quality of life but only if we get the policies right.
Conventional economics provides an increasingly poor guide for economic policy and should be replaced by an evolutionary economics framework.
Rob Atkinson contributed the chapter "Public Policy, Innovation and New Technologies" to the textbook "Guide to U.S. Economic Policy."
Robert Atkinson contributed the chapter "Innovation in Cities and Innovation by Cities" for the book "Creating Competitiveness: Entrepreneurship and Innovation Polices for Growth."
In a chapter for the new book Practicing Sustainability, Rob Atkinson wrote about sustainability from an innovation economics perspective.
"Innovation Economics: The Race for Global Advantage." This new book delivers a critical wake-up call: a fierce global race for innovation advantage is under way and the United States is running the risk of losing.
Daniel Castro contributed a chapter titled "U.S. Federal Cybersecurity Policy" in the book "Cybersecurity: Public Sector Threats and Responses."
Rob Atkinson contributed a chapter titled chapter "Who's Who in Internet Politics" for the book "The Next Digital Decade: Essays on the Future of the Internet."
Supply-Side Follies: Why Conservative Economics Fails, Liberal Economics Falters, and Innovation Economics is the Answer
Supply-Side Follies methodically debunks the common assumptions of conservative economics and demonstrates why it is a flawed doctrine that is setting up the U.S. for a major economic downturn in the near future.
Taking into account the historical record, the book discusses the shortcomings of prevailing liberal and conservative economic doctrines and lays out a new growth economics agenda aimed at maximizing the productivity and innovation-enhancing forces of the New Economy.


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Find records of Alejandro Amarales
Find birth, death, marriage, military, and other records of Alejandro Amarales at Ancestry.com.Search for records
Biography & Family History Add details
Alejandro Amarales (1945 - 2007) was born on January 25, 1945. He was born into the Amarales family.
There are no known marriages or children on record for Alejandro. Alejandro died on July 14, 2007 at 62 years of age.
Alejandro Amarales's last known residence is at San Juan, San Juan County, Puerto Rico.
The data on this page comes from the official record for Alejandro Amarales in the SSDI (United States Social Security Master Death Index). According to information provided to the SSDI, this death record has been verified by a family member of the deceased. This data can be considered very accurate. What is the SSDI?
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SAN ANTONIO - Results of final, round 3 eliminations in Exhibition at the 2013 Nitro Jam Series, IHRA San Antonio Nitro Jam presented by CarSafe & Good Vibrations Motorsports Day One:
Car#-Driver(Opp'nt)-RT-----ET---Speed-----Car#-Driver(Opp'nt)-RT----ET---Speed Bye 014 Richard Hutchins E3 ****WINNER**** 0.862 9.859 133.89 Prior rounds: E1 0.690 10.024 122.05A VW cab-forward with a big Chevy in the back. Should be a natural wheelstander, but this time out he was late bringing the front wheels up and they were back on the track around half track.
Car#-Driver(Opp'nt)-RT-----ET---Speed-----Car#-Driver(Opp'nt)-RT----ET---Speed 905 Rich Hanna 105 Ken Hall E3 0.025 5.875 269.46 ****WINNER**** 0.030 5.867 272.56 Prior rounds: E1 (N On File ) 0.002 4.055 199.20 (N On File ) 0.039 4.066 201.70Another very close race between the two and this time it was Hall who turned on the win light (at the quarter-mile this time) by four thousandths, nipping Hanna in the lights.
Car#-Driver(Opp'nt)-RT-----ET---Speed-----Car#-Driver(Opp'nt)-RT----ET---Speed TRAIN K.C. Jones JETTR James Paul Kelley E3 ****WINNER**** 1.423 7.123 196.42 -0.400 9.327 215.93 Prior rounds: E1 (J Paul Kelle) 0.281 6.738 234.13 (K Jones ) 0.436 7.031 224.44Kelley beat the green by a full bulb, giving Jones the easy win.
Car#-Driver(Opp'nt)-RT-----ET---Speed-----Car#-Driver(Opp'nt)-RT----ET---Speed LES Les Shockley Bye E3 ****WINNER**** 0.541 7.774 209.59 Prior rounds: E1 0.000 7.311 209.59Shockley closed the evening with another fire and noise show.
IHRA: 10 Most Recent Entries [ top ]
Nov 24- Summit Super Series Champions Named at San Antonio Raceway
Nov 24- IHRA Announces Return to Sportsman National Event Racing At NJDRS =
Nov 24- IHRA to Add New No Electronics Index Class at Select Events In =
Nov 13- IRG Sports + Entertainment Acquires Maryland International Raceway
Nov 12- IHRA Welcomes 710 Dragway, Douglas Dragway
Nov 06- IRG Sports + Entertainment Acquires Cordova Dragway Park in Illinois
Nov 06- IRG Sports + Entertainment Announces Major Financing And Acquisition Of Two Tracks
Oct 23- 2014 IHRA Junior Dragster Champion- John Tolisano III
Oct 16- IHRA World Champions Recognized at Nitro Jam Awards Celebration
Oct 13- IHRA Crowns 2014 World Champions At Summit World Finals


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