text:
Morso - NYC
- Address:
420 East 59th St,
New York, NY 10022Neighborhood:
Upper East Side
- Cuisine:
ItalianPrice: $30 and under
Morso - NYC
- Dining Style: Casual Dining
- Website: http://www.morso-nyc.com/
- Phone: (212) 759-2706
- Hours of Operation:
Dinner: Mon-Sat: 5:30pm - 11:00pm; Sunday : 5:30pm-10pm Brunch: Sunday: 11:30am - 3:30pm
- Payment Options: AMEX,Diners Club,Discover,MasterCard,Visa
- Cuisine: Italian, Contemporary European
- Executive Chef: Pino Luongo
- Dress Code: Casual Dress
- Accepts Walk-Ins: Yes
- Additional Details: Banquet/Private Rooms, Bar Dining, Beer, Chef's Table, Counter Seating, Delivery, Full Bar, Happy Hour, Patio/Outdoor Dining, Personal wines welcome, Personal wines welcome (corkage fee applies), Private Room, Takeout, View, Weekend Brunch, Wheelchair Access, Wine
- Catering: Experience the same great cuisine in your home or location of your choice. We are delighted to cater your next event from 20-2000. Please inquire with our private dining department.
- Private Party Facilities: Our Private Dining Alcove is steps away from our main dining room and offers guests a majestic view of the 59th Street Bridge. This semi-private space can seat up to 14 guests in a fun, casual ambience.You may order a la carte or select some of Morso signature dishes to create a special celebration.
- Private Party Contact: Ezma Samuel 2127592706
- Special Events: email@example.com
Getting there
- Cross Street: First Avenue and Sutton Place
- Public Transit: 4,5,or 6, N, Q, R Subway to 59th Street
- Parking: Public Lot
- Parking Details: Morso is happy to offer our guests $3 off every hour of parking right next door to our restaurant at 422 East 59th Street between 1st Ave & Sutton Place.
Entrances on both 58th & 59th Streets. Present your parking ticket to us for validation. Validated tickets must be presented to garage cashier at check-out. SUV rates may apply
A word from Morso - NYC
Morso is a culmination of a life in food and a passion for culinary excellence. Thirty years ago Pino Luongo, brought the then unfamiliar flavors and culture of authentic Tuscan cooking to New York City. With the essence of his homeland at heart and a truly original style of cooking, Luongo shaped the Italian menus and restaurants we consider as classics today. For Morso, his values and passion remain unchanged. Great, seasonal ingredients, skillfully prepared, shared with family and friends. Taking little bites of inspiration from all over Italy and the Mediterranean, combined with Pino's finest signature dishes; Morso represents a quintessential dining experience—authentic contemporary cooking in a vibrant and relaxed setting.Continued
Foodspotting photosSee all photos
Morso - NYC reviews from OpenTable diners
98 reviews since July 30, 2014
- Food4.2Service4.1
- Ambiance4.1Noise LevelModerate
neighborhood gem (72)fit for foodies (52)great for outdoor dining (47)good for groups (27)special occasion (20)great for lunch (17)great for brunch (11)romantic (10)notable wine list (9)hot spot (7)scenic view (6)late-night find (5)vibrant bar scene (3)kid-friendly (3)Show More
- Quality with styleNYCtravVIPDined on 11/22/2014Excellent preparation and great service make this a consistently enjoyable dining experience for us. Pastas are standouts but you can't go wrong with anything on this well balanced menu. Go and you'll come back!Special Features:I would recommend this to a friend.
- UnderwhelmingBethluvDined on 11/16/2014Went for brunch Only thee tables including us. Service was terrible Food was mediocre Screwed up the orders Coffee was served in metal pots with no lids so after five minutes the extra coffee was cold Just seemed to be extra stupid Will not return Better options elsewhereSpecial Features:
- Consistent and DependibleKimiVIPDined on 11/7/2014Great service, food and always a pleasure to see Pino... Thoroughly enjoyed!Special Features:
- Bring Ear plugs and a two way radioSanford6810Dined on 11/6/2014The noise level at Morso is so high that at one point my friends and i were writiing notes to each other. What is the matter with restaurants in this city? Everyone knows New Yorkers are loud and aggressive, but lately when we go to restaurants there are people there who are obviously deaf or think they have to let everyone else in the restaurant know how witty they are, talking at the top of their lungs. At one point when we were trying to give the waitress our dinner order, even she couldn't hear us. The food is okay. Nothing to write home about
- 25th Anniversary CelebrationappleannieDined on 11/5/2014We had a delightful evening at Morso. It was our first visit. We were greeted warmly by the lovely hostess and the night just went up from there. Service was excellent and the food amazing. Every dish was delicious. We shared the special chicory salad with anchovies, the sardines with onions and raisins, and the amazing Timbale. (If you've craved this ever since viewing The Big Night, here's your chance to taste it. You won't be disappointed.) Oh, and let me not forget to mention the delectable desserts - warm passion fruit tart and the lightest cannoli ever! We can't wait to go back.Special Features:
- Group meals in pleasant settingnycadventurouseaterDined on 11/3/2014Morso is a go-to place for us, especially for group meals in a much more pleasant setting than most restaurants that can flexibly accommodate large groups. Warm, gracious service. Delicious salads, appetizers and pastas. Entrees we've had have been quite good, though my experience there is limited - we've tended to stick with pasta entrees. Desserts at least quite good, but their tiramisu is first rate - strong espresso flavoring, delicate cake, very creamy mascarpone. Lovely shaved artichoke salad, intensely peppery cacio e pepe, delicious octopus. Wine list skews a bit towards the steep side. I haven't done a count, but my guess is that only about 10-15% of the red wines are under $50, with at least half the list or more north of $60.Special Features:
- Neighborhood gemsuttonplaceVIPDined on 10/29/2014I live in the Sutton Place area and find this a convenient location where I can get good food and service on a consistent basisSpecial Features:I would recommend this to a friend.
- neighborhood gemlluv2dineDined on 10/26/2014when it opened next door to me near the queensboro bridge i was skeptical but i've been 3 times now and the food and service are always outstanding!Special Features:I would recommend this to a friend.
- Sometimes less is...writer100VIPDined on 10/24/2014If you wonder if the "small" option for many of the entrees will leave you hungry, be assured they will not. Particularly if you begin with the evening's soup in a bowl big enough to share. And then there are the popovers which arrive unbidden but oh so warmly welcome.If your chair abuts an aisle you may find yourself brushed by the occasional passing waiter, and that's really the only demerit I can assign. Morso has a fairly senior clientele (I am one) who too often raise their voices to be understood by dining partners just across the table. When many such voices are raised, you may wish for a hearing aid--just so you can turn it down.Special Features:I would recommend this to a friend.
- corked winelbt22Dined on 10/23/2014first choice of wine the bottle was corked! i know this happens, but the waitress tried to convince us it was fine.. really? otherwise, food was good and overall pleasant experience.
- Keeps getting betterjmjrVIPDined on 10/20/2014Pino's vision keeps getting better and when the new terrace is complete the experience wil be wonderful. Always fresh, authentic Tuscan food.Special Features:I would recommend this to a friend.
- NoiseNeighborVIPDined on 10/15/2014The noise level is overwhelming to the point it makes dining less than pleasurable.
- OpenTable Diner Since 2009Dined on 10/15/2014Service poor. Waiter forgot to put one order in. When dish came - veal scalloping- meat was so tough it could not be cut. This was replaced with a mixed sea food dish in which half of the items were hard and not good. Drink forgotten til reminded.
- Superb!EffieVIPDined on 10/14/2014This is such a wonderful restaurant...and, we are very lucky to live close by. While we often come back for our "favorites" it's fun (and always satisfying) to try something new that Pino suggests. Morse never disappoints. Grazie mille!Special Features:I would recommend this to a friend.
- OpenTable Diner Since 2014Dined on 10/13/2014Loved it the first time we were there. Not so pleased the second time.
- Consistently excellentNYCtravVIPDined on 10/12/2014amiable and caring service plus excellent Italian cuisine make this a frequent choice for us.Special Features:I would recommend this to a friend.
- OpenTable Diner Since 2009Dined on 10/4/2014Ambiance pleasant, comfortable,inviting, food excellent-like the option of half portions!Special Features:I would recommend this to a friend.
- Dr. Steven TunickBHound47Dined on 10/1/2014Have been there several times over the last two years. Find the whole experience excellent in all aspects. I have no criticism or complaints. Loved the ambience, the food, the service. Good vibe. Had a dish that we had in Rome last year, Bucontini e Cacia e Pepe which was excellent. Highly recommend this place. It is a find.Special Features:
- HelperVIPDined on 10/1/201445 minutes after our appetizers and no entree. We had to ask the server about it. He should have been on top of it and the kitchen screwed up. Although the food was good,not sure if we would return. This shows poor management.
- consistently goodIknowwhatIlikeDined on 10/1/2014This neighborhood restaurant has it all. Good food, attentive service with a casually sophisticated atmosphere. The wine list is small and more than adequate with relatively modest pricing. ALWAYS a pleasure to dine at this restaurant. Also, the owner Pino Luongo has been there every time I have been there. Another great sign of "quality control".Special Features:I would recommend this to a friend.
- Sutton Place GemsuttonplaceVIPDined on 9/28/2014This is a neighborhood gem in Sutton Place where you can get good food, great service and be in a very comfortable setting.Special Features:
- JohnJohnVIPDined on 9/21/2014Outstanding food and service, a must place to go when in New YorkSpecial Features:I would recommend this to a friend.
- Our go to favoriteNYCtravVIPDined on 9/16/2014always congenial staff and great food make this our go-to favorite! They will make special pasta samplers for you if you like but the ones on the menu are terrific!Special Features:
- Returning guestsmoomoo32Dined on 9/13/2014They were wonderful to us. Accomodated us graciously at corner table away from the kids birthday party Will definitely returnSpecial Features:
- Great Greek foodBostonFoodieVIPDined on 9/6/2014I am in from out of town on business and wanted delicious late night Greek food without too much fuss. This place was perfect: tasty, well-prepared food, courteous service, and nice tables outside at which to enjoy it all. Morso would be a fun place to go with a group of friends.Special Features:I would recommend this to a friend.
- JohnVIPDined on 8/29/2014A place to be visited when in New York, great food n service a neighborhood gem.Special Features:I would recommend this to a friend.
- CookieDined on 8/18/2014The service was wonderful and attentive. The summer salad special was delicious and the cacio e pepe pasta was perfect - tasty, but not too heavy. Just the right portion size. Such a pleasure to dine outdoors, and not be right on the sidewalk amid all of the traffic. Close your eyes and you are in Italy. Delightful!Special Features:I would recommend this to a friend.
- My Neighborhood FavnotsogoodVIPDined on 8/9/2014It seems like I eat at Morso at least once every other week. I have introduced more people to this restaurant than any other. The food is excellent, ambiance is very good, service nees to be worked on. 3 times we were served other peoples meals. Somehow, I don't want to complain. I'll just hope the practice and get it right. I'll be back probably next week.Special Features:
- Surprise--in a Good Waywriter100VIPDined on 8/5/2014Too often neighborhood places are well, in the neighborhood--meaning their great strength is convenience. Morsi is a really good Italian restaurant that offers fine foodm good wine selection, personable service. And the half portions (full size available too, of course) means you can sample a bit more widely without feeling gluttonous. And in the warm weather, like now, you can eat on the broad terrace under Cinzano umbrellas--albeit with a view of the side of the 59th Street bridge. Still, close your eyes, and you can imagine you are somewhere in Italy on a terrace overlooking the Med. Only the occasional truck in need of a new muffler will spoil your dream.Special Features:
- great menuOpenTable Diner Since 2009Dined on 7/31/2014Morso has a nice range of Itaian food and offers half portions if ao desired. Servce is great , customers ae local and happy to be there. We enjoy the food very muchSpecial Features:I would recommend this to a friend.
- The Dogs have it!!!!StarrtreksVIPDined on 7/30/2014I have eaten at Morso's on several occasions in the outdoor area and found it delightful but on Wednesday evening it was most unpleasant There were at least 6 dogs and I assume with their owners, some quiet, some not so quiet, some on owners laps and being fawned over I find taking ones dog to dinner quite rude. I am a dog lover, but find sharing dinner at a lovely restaurant most unpleasant. Our server Michael was not at his best I spoke to the hostess who informed me dogs are very welcome!!!! I will return because the food and ambiance is lovely and the service is usually quite good I hope there will no dogs at dinnerSpecial Features:
- The following 274 reviews are from the Morso - NYC reviews archive.
- Pino's magic!jmjrVIPDined on 7/27/2014This is Pino's gem. He brings real Italian food to those who appreciate the "Big Night". Everything is fresh and the crowd is vibrant. Nice to get off the uptown 2nd and 3rd ave scene.Special Features:I would recommend this to a friend.
- excellentHarvVIPDined on 7/25/2014As always, Morso continues to be an outstanding restaurant.Special Features:
- excellentHarvVIPDined on 7/21/2014Always a pleasure to dine at Morso. Food, service are consistently above average.Special Features:
- Very nice, but noisy outsideExNewYorkerDined on 7/18/2014We ate out on the patio. The food and service were very good, and the staff all liked our 11-month-old child. However, it is next to the Queensboro bridge - noisy enough that conversation is affected.Special Features:I would recommend this to a friend.
- Great fishCrinkVIPDined on 7/12/2014We tried two of the specials for the day: grilled sardines on a bed of cooked fennel, and skate served with Tuscan fries and greens. Both were some of the best we've ever eaten. The salads were imaginative. One of us had a salad special of nectarines, peaches, avocado, greens, and feta cheese, the other a salad of cooked summer vegetables. The outdoor dining is in front of the restaurant, separated by planters from the sidewalk, across from the Ed Koch Bridge. Pleasant enough. There was the constant hum of traffic noise from the bridge but very little traffic going along that part of 59th St.Special Features:
- food good, service badFoodmanDined on 7/12/2014The brunch food was very good. It only took 50 minutes to get it -- and the restaurant was half empty! Took 15 minutes, after we sat, for our waiter to bring over menus and water. Seemed as if they were interns from another country with the lack of speed and confusion.
- Great food...but thats allamywestvillageVIPDined on 7/9/2014The fish is delectable. ...fresh and well prepared...the pastas yummy. However on a steamy summer night, they had the door open to feed the diners sitting outside so it was uncomfortable and sticky inside, the tables are so close together that you have to strategize how to navigate to the restroom, the service was very slow (we got our meal an hour after ordering) and it was too noisy.Special Features:
- Restaurant in our buildingJbnyuVIPDined on 7/8/2014Like a cafeteria for the Sovereign. We can say on the spur of the moment...let's go downstairs for dinner. The ambience and staff are amazing. Always feel like I am at home.Special Features:
- Paris5thDined on 7/7/2014Food was good--my friend had sole which was excellent. I had a pasta a la vongole--a bit disappointing. The clams were out of their shells and tasted rubbery, but the pasta itself was delicious. Salad was terrific.Special Features:


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Tom Stoppard's Rock 'n' Roll at The Stage Theatre
* Additional fees apply.
The last date listed for Rock 'n' Roll was Sunday March 7, 2010 / 2:00pm.
Currently at The Stage
The Rainmaker -- Tony-Nominated Romantic Comedy Classic
- Full Price:
- $40.00 - $56.00
- Our Price:
- $20.00 - $28.00
The Stage launches its new season with a longtime stage favorite, The Rainmaker -- a sho...Learn More
Venue Details
Parking on a Sunday afternoon was challenging, and after 15 minutes of looking for street parking I ended up in one of the many lots that increase their rates when there's a show...10 dollar flat fee for parking---A Weekend With Pablo Picasso travel • Nov 17 2014 star this tip starred
We had a delicious dinner before the show within easy walking distance at Arcadia.Bonnie & Clyde dining • Jul 03 2014 star this tip starred
Reviews & Ratings
Featured review from Lois Brown
view more less of this review
I love this theater. Every seat has a good view and the acting is always superb. The play istelf was very enlightening and thought provoking. For those of you thinking this is a Rock N Roll musical, please read about the play before attending.
star this review starred report as inappropriate
I recommend you take time to read the program or check out the website before viewing. The production is more about politics then it is about rock and roll but that said I really enjoyed it. There are strong performances particularly by Jonathan...continued
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The play is great (It could be more interesting for me as I know the recent history of Czechoslovakia well). The theater is very nice, small place with a good view from anywhere. The actors were enthusiastic. The costumes and lighting were...continued
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This was our first experience at San Jose Stage Co. We're looking forward to many more shows. Exceptional talent!
Quotes & Highlights
"A celebration of the pagan spirit embodied by rock 'n' roll." —The Guardian
"Splendid, illuminating entertainment that resonates with emotion. There will always be Rock 'n' Roll_." —_Associated Press
This extraordinary theatrical event, nominated for four Tony Awards and three Drama Desk Awards, makes its South Bay Premiere in a uniquely intimate production at The Stage. It's August 1968, and Russian tanks are rolling in to Prague. Jan, a Czech student, lives for rock music; Max, an English professor, lives for Communism; and Esme, the flower child, is high. By 1990, the tanks are rolling out, The Stones are rolling in and idealism has hit the wall. Stoppard's sweeping and passionate play spans two countries, three generations and 22 turbulent years, at the end of which, love remains — and so does rock 'n' roll.
About the Ticket Supplier: San Jose Stage Company
Founded in 1983, San Jose Stage Company is a professional theatre company dedicated to producing the works of contemporary playwrights that speak to the conditions, hopes and fears of all mankind.
San Jose Stage operates in their own theatre facility in downtown San Jose. They produce five plays per season on an annual budget of approximately $850,000.00 and serve over 25,000 patrons each season.


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Junior Member
when will they get to working on twitch!!!!!!!!!!!!!!!!!!!
Senior Member
Very interested to see how much of a difference the Garen tweaks will make. Also, really happy with the way the Panth buffs look. I might just have to start playing him again. Also just need another 1400IP for Skarner. league of legends life is good. :P
Yelling Guy
NIcely done. = D
Little scared to fight a good pantheon now let alone before....
love this patch
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Not enough of Fiddle... Just not enough. :'(
He's still so ridiculous. :P
i believe (for all the guys that talk about Renekton buffs) that slice and dice should have lower cd and/or dice armor reduction should have and increase in duration (dunno 1/2 secs) because everybody with 50 rage will always attempt to stun for awesome dmg bonus and longer stun or to heal a lot, its more like : dice's enraged is not worth loosing the rage in comparison with the other skills enraged versions.
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I was hoping to see the Ignite bug on Yorick fixed where his ultimate when used on himself would not bring him back to life if died from Ignite.
Other than that this looks like a great patch!
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text:
SAN FRANCISCO (AP) — University of California leaders on Wednesday called for an expansion of online courses to help the 10-campus system contain costs, broaden access and hold down tuition rates.
University of California wants more classes online
UC President Mark Yudof said the university plans to launch several online education initiatives in the next few months, including an incentive program to encourage faculty members to create digital versions of high-demand, entry-level courses.
"It's no secret that UC has hit a wall with regard to traditional instructional methods," Yudof said at the UC Board of Regents meeting. "The finances simply no longer exist to support the old model of instruction in many ways."
The board meeting in San Francisco was attended by Gov. Jerry Brown, who has been pressing California colleges to embrace online education to make college more accessible and affordable.
In his 2013-2014 budget, Brown has proposed giving California's public colleges and universities more money, thanks to the November passage of Proposition 30 tax initiative. But in return, he wants them to control expenses, stop raising tuition and move more classes online.
"There's a brute reality out there," Brown told the regents. "There's not a luxury of sitting in the present trajectory unless you don't mind paying ever increasing tuition."
Brown's budget plan would increase state funding for UC by $250 million — less than what the university had requested, but a welcome change from several years of deep budget cuts.
At the meeting, Yudof thanked Brown for the proposed budget increase and said he believed UC could meet the governor's challenge. He suggested that campuses may have to maintain higher student-faculty ratios in the future.
"We are committed to doing everything we can to keep tuition down," Yudof said. "We are committed to developing the best online education system for our students. And we are committed to maintaining fiscal discipline."
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text:
Deer running in front of your brand new car causing an accident.
My new LEXUS was just BambiBombed!
by Gregory and Tari May 26, 2008
A deer by the side of the road.
We had to drive slow because of all the bambi bombs.
by IamTree August 30, 2010
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woodward ave - royal oak, mi
i have lived in troy for the past 19 years and have eaten all over the city. yesterday i was driving on woodward and i got to thinking about a couple of places that i have driven by hundreds of times but have never tried. please share your thoughts on the following:
chicken shack - looks like a carry out/diner type place. big bright sign out front. around 5:30, the small lot had quite a few cars and there was about a dozen people visible through the wall of windows. obviously, they do chicken. is at good? do they do anything else?
pasquale's - giant italian place with a huge parking lot that their security guards will not let you use if you are going to walk over to duggan's. i have heard the pizza is good.
aspen - i have read reviews in the paper that say the food is surprisingly good for a bar.
onion roll - another diner-type place where i suspect sandwiches are featured.
re: Jim M
Agreed with Jim on Chicken Shack. I like it, but it is just that: basically fast food. And yes, the chicken is broasted. They do several other things, especially ribs, and I guess lots of people like the ribs, too, but it's not where I go when I want ribs.
I'm not enamored with Pasquale's. I've eaten there maybe 4-5 times over the years, and to this day I don't understand the appeal of the place. It's well-attended, but the food is decidedly mediocre at best. *Don't* get veal there...it's an entire waste of money. To me, it's pretty low-end Italian for mid-scale-to-upper-scale prices. Being that the Detroit area is absolutely *littered* with tons of (often better) places for Italian, I vote thumbs-down here.
Onion Roll is a place that I've never been personally, but have heard *nothing* but good things about. I guess I just can't get over the way the place looks or something.
Not familiar with Aspen.
A bit further up Woodward is Falaffel King, which is pretty good Middle Eastern for relatively cheap. I *love* their chicken shawarma sandwich for $4.19. It's a meal by itself, or darned near it. Nice people, too.
Also up there is Mt. Chalet II, which, for a bar, has surprisingly good food, at least the few times I've been there. I am utterly *unimpressed* with their drinks (their Amaretto Sour is positively horrid, which they fully admit to), but the food is far better than typical bar fare. When I eat there, I'm happy I've done so.
Oh, and Thai House Express is, bar none, the *worst* "Thai food" I have *ever* had the displeasure of ingesting. When I was done "eating" (I can count the number of bites I ate on one hand), I threw out the remaining 90+% of the "food" they served. Avoid this place like the freaking plague. It's an abomination, especially when you consider how many great Thai places there are around the area.
Hope that helps!
re: boagman
chalet, aspen, skiing....bad mix up on my part. i meant mt. chalet and wrote aspen (an underwhelming place on hall road east of lakeside).
re: xman887
Heh. I can understand why you made the Aspen/Chalet dyslexia move. But yes: Mt. Chalet's food is better than you'd expect it to be, and they do offer a good deal more than standard bar fare. I'm not saying that you'll be blown away, but you may very well be pleasantly surprised by what they're offering, as well as how nicely they prepare it. Aside from whipped potatoes (which I should know well enough to avoid getting *anywhere* by now...), their food has always been enjoyable in my experiences there.
It's funny that you should say that about Aspen. My impression of it is the same as yours, but two non-foodie friends of mine *really* like the place, because they're meat-'n'-taters people, and I guess they do that pretty well there. They'll make the drive up there from Hazel Park, and I think to myself: "You're joking, right? All that way? Must be some steak..."
re: boagman
Wow, Mt. Chalet is still around? My dad used to take me there for happy hour. FWIW, their clam strips were pretty good in 1988. Also, I was like 9.
In Minnesota, restaurants are like mayflies. If someone recommends a place at 10am, you'd better get there before 5, or it'll be closed.
I didn't think Pasquales was good, even as a kid.
re: kevin47
Bite your tongue. With the way things are around the country, but *especially* here in Michigan, places both good and bad are suffering to the point of having to close. We want the good ones to stick around, like Mt. Chalet.
And you're dead-square-on about Pasquale's.
re: boagman
How is Siam Spicy? East side of Woodward near Webster, I think. Drive by all the time and heard good things from friends, but have never been. No offense to my friends, but I trust your opinion more than theirs. :)
re: aliasrlm
It's not bad. I've eaten there about 4 times or so, and haven't been turned off by it once. It certainly isn't my *first* choice for Thai, but it's a decent place that has one very important thing going for it: it's open on Sunday, which 99.999999% of other Thai places aren't, apparently. When you're dying for Thai on a Sunday, it'll work.
A guy from my church swears by a certain dish of theirs, which I can't for the life of me remember at the moment. I'll have to ask him on Sunday and get back to you with it. When I've eaten there, I've been satisfied, but I'm much more into Pi's in Hazel Park or Sterling Heights.
re: boagman
Good to know. We still haven't been to Pi's, which is crazy considering it's probably not too far away (we're in Ferndale). Thanks again!
I've eaten at Pasquale's at the request of family members many, many times. I've never cared for any of their pasta dishes, but the pepperoni they put on pizza is wonderful. Cheese and crust, not so much (yet better than the big chains). But the pepperoni itself is worth it.
When the wife and kids ask me to go on a chicken run, I drive past KFC to get to Chicken Shack. Their potatoes have acquired a reputation, and I admit I can't resist them either.
re: dearborn barkis
Now, see, when it comes to the KFC/Chicken Shack comparison, there just *is no way* to compare the two to me. I like both, but while they both involve deep frying (which is basically what "broasting" is), the taste of the two are just miles away from each other. Yes, they're both chicken, but they're just nothing like each other. I guess you really *can* chalk one up for the Colonel's recipe of 11 herbs and spices...and when you've got a taste for KFC, Chicken Shack won't cut it. When you've got a taste for Chicken Shack, KFC won't cut it.
I will *fully* admit that the sides from Chicken Shack are better than KFC's, though.
re: boagman
Agreed. Both KFC and chicken shack broast which is a combination of deep frying and pressure cooking. The Colonel gets the credit for being the original. In spite of not being a big fan of corproate chains/franchising It's hard to deny the temptation of KFC every now and then.
Chicken Shack is straight fried chicken with out the herbs and spices. I enjoy both but neither will substitute for the other.
There is a Chicken Shack on 23 mile in New Baltimore and one in downtown Rochester as well (A block West of Main on University).
I never understood the attraction of Pasquales but I don't blame them at all for not letting Duggans patrons utilize their parking.
re: grouper
Dis-a-freaking-gree. I *hate* YaYa's wimpy little pieces of chicken meat, and I keep waiting and waiting for the day that the place finally dies for lack of business. If you want overpriced, tiny, and pretty tasteless pieces of chicken served by idiots, then yes: by all means, eat at YaYa's. Just don't say you weren't warned.
re: boagman
Sorry, I never get the chicken pieces as I always get the shredded chicken salad. Which is better than most as there is no mayo involved. The YaYa's in the Flint area where they started usually have a pretty good following.
re: grouper
Ah. Fair enough, as I honestly can't speak to the chicken salad. It may very well be good...I just haven't had nor gazed upon it. I'm rather surprised there's no mayo...what do they use to "bind" it together? Or is it just dry?
Avoid for a chicken dinner, though...hideously small chicken at exorbitant rates.
re: boagman
The chicken is shredded and relies upon the taste from the flame-broiling. They also provide a dressing that comes in low-fat, that I think is yogurt based. When you just want something that's not too heavy, but provides some lettuce and protein, it's the place to go. For years I loved their chicken noodle soup which I thought wasn't bad for take-out,,,,then I found Nino's chicken nooode. So much like my own I can fool myself!!
re: boagman
I absolutely love Yaya's chicken.
I agree it is pricey, but the grilled, marinated chicken is awesome in my book.
I have never had Chicken Shack, but I would certainly NEVER choose KFC over YaYa's.
I'm a Chicken Shack fan, if the chicken is hot. We've gotten it a couple of times where it has either sat for a bit or was just not correctly cooked and was sitting in a pool of nasty grease. The potatoes and coleslaw also are excellent. When I worked in Troy I would get chicken from T-Birds on occasion and it's similar to that.
I've been warned away from Pasquales--"Franco American Italian"--so have never been.
Onion Roll makes a decent sandwich, but I prefer Bread Basket or Samuel Hoffmans in Clawson.
Pasquales is 80s italian heavy red sauce nothing to write home about.
Onion Roll - Not a diner it's pastrami and corned beef mostly with some other choices. Was good one time I went and ok another time.
Onion Roll is pretty good, but I wouldn't put their sandwiches at the level of, say, Bread Basket. If you go to the coney places on Lafayette in Detroit for the entertainment of watching the staff scream at each other in Greek, Onion Roll may be your type of place. A lot of arguing going on behind the counter.
I've only eaten there once, but I'll second (fifth? tenth?) the consensus on Pasquale's. Wouldn't pass muster in a Jersey diner, let alone a real Italian restaurant in Jersey, and they're pretty pricey.
"...pasquale's - giant italian place with a huge parking lot that their security guards will not let you use if you are going to walk over to duggan's. i have heard the pizza is good."
Forget Pasquale's bland pasta and Duggan's Big-Boy-wannabe Big Chief--I'd rather have a Big Mac--and jaywalk across Woodward to Red Coat.
re: dearborn barkis
*Or*, you could just skip Mickey D's altogether and get a Redcoat burger made with the stuff that comes on a Big Mac, which I found wonderful when I tried it.
Oh, and positively *do not* try to jaywalk across Woodward by Duggan's and Redcoat. Believe it or not, I actually *did* get a jaywalking ticket doing just that, and no, I wasn't drinking, and no, it wasn't on Dream Cruise day.
I was *ticked off* about it.
Pasquale's - absolutely terrible food. The pasta, pizza, salads, all VEry VEry VERy forgettable.
Onion Roll - Makes a pretty mean pastrami sandwich. They're not as good as say Zimmerman's or Bread Basket, but it comes very close. Cash only. The cook guy is really friendly.
Falafel King. Cheap, fast, always good. Great place to pick up some quick eats.
Vinsetta Grill - we recently tried that place, not bad! Willing to give it a second shot. Their forte are burgers as well. Their "niche" is the amount of toppings you can put on it. Very creative.
re: donbui82
Agree Pasquale's is not worth the time it is old school heavy Italian and pretty uninspired. Directly across the street is an Italian Restaurant at the end of a strip mall the name is alluding me it is a mans name though. The food is much better cheaper and really hits the spot.
re: donbui82
Thanks for the comments about Vinsetta - that is one of those places that I've never tried either - whenever I drive by it, I say to myself that I should try it - but I always forget its an option when I am deciding where to eat. I live in downtown RO, so I usually don't get beyond those restaurants when I am brainstorming and I wholly forget most of the woodward options.
This is a second vote for the pepperoni at Pasquale's. They use the small pepperoni, the ones that curl up at the sides and gather little pools of grease in the middle. The pizza in general is great though. Wonderful ratios of crust to sauce to cheese. Floppy too, which I adore. I also happen to rather like their pasta and sauce as well. Especially the meat sauce. No one does meat sauce right like Old-School American-Italian. You can go take a "real Bolognese" and go stick it.
But it seems many seem to hate Pasquale's because they are not a "real" Italian restaurant or something of that nature. Not a La-tee-da-oh-so-precious-authentic Italian straight from the Old Country. (or at least one of the many posing as such)
Well good for them I say. I love their honest, simple, and, at least in my apparently deluded opinion, delicious fare. Pasquale's is authentic-----Authentic-American-Italian. Sometimes that's what people want. Heavy, meaty, 1000s of calories, not too subtle, but quite effective.
re: RNemes
I'm honestly glad that you like them, as it would seem that you're quite the minority opinion. You must admit, though, that what they serve *for they price that they serve it at* is decidedly expensive. I find their price-to-quality ratio to be appalling myself, and I'm not even that picky about my Italian food and/or restaurants.
Don't misunderstand: I'm not condemning Pasquale's to a fate any worse than, say, Como's in Ferndale (which I'd probably place in the same, exact category a Pasquale's, if not worse), but really now: Pasquale's bills itself as an Italian restaurant more than just a pizza joint...as such, it has to be rated accordingly.
re: boagman
My little rant being done, I do understand where you are coming from. Perhaps I have a problem separating nostalgia from real appreciation of quality on some level. I dunno.....
Anyhow, I have always greatly appreciated your comments boagman. Diamond Jim's and Stage Deli come to mind as a couple places you have turned me onto. (and you have my eternal gratitude for those!)
So while we are on the subject of Italian...if you could only go to one Italian restaurant in SE Mich ever again, which would it be? I *will* go there.
re: RNemes
> if you could only go to one Italian restaurant in SE Mich ever again, which
> would it be?
My overall choice would be Pasta Fagioli @ Franklin & Square Lake. It's a very
small bistro that does a LOT of carry-out business. Prices are reasonable and
they encourage you to bring your own wine.
I rate the overall work of the kitchen as Very Good with an occassional
Excellent and/or Just-okay. Lelli's and Andiamo are con$i$tently better; al$o
con$i$tently more expen$ive.
For lasagna; I still trek to Ruggero's in Flint. Their lasagna is available using
italian sausage (yum) or ground-beef (why bother).
re: rainsux
Oh my gosh, I grew up down the street from the original Ruggero's and to this day rate most restaurant lasagna against theirs. It was the first lasagna I had ever eaten and loved it way back then. For my 30th high school reunion, my friends and I went to Ruggero's and passed on the dinner served at the reunion. We all ordered our favorites from junior high school...it was a great dinner.
re: RNemes
What's my favorite Italian destination? That's a darned good question, as Italian is certainly *not* my forte/cuisine of choice. I honestly don't have a whole lot of experience in it since I rarely get an Italian craving...you'd probably have a heck of a lot better knowledge on it than I do, quite frankly.
I took a page from your book and looked at Pasquale's online menu, and if the pricing currently posted there is correct, then I'd be more prone to agree with you: it wasn't as expensive as I had remembered. It's entirely possible that they've reduced prices in the couple of years since I've been there, but I absolutely recall being *appalled* by the price they charged my friend for a veal dish which was so lousy, she wouldn't take any of it home. Considering that I hadn't enjoyed what I'd eaten either, I was wondering how a place like that would be able to stay as popular as it had. Pizza and location would explain a lot, I guess.
Glad you like DJBs and Stage! I've actually been hankering to go back to DJBs lately, but haven't been in a couple months. It's time!
re: boagman
As an addendum here I looked at the Pasquale's menu just now and I honestly can't see the problem as far as prices go. The entire menu is basically under 20 bucks, and a huge number of dishes (entrees that is) are under 10. Seems pretty dang cheap to me in this day and age.
Anyhow, that aside, I still want to know what you consider the ultimate Italian in the SE Mich area, as I am sure it will be quite awesome. My real go-to place, as an Ann Arborite, is Paesano's, if that is any meaningful gauge.


text:
USDA Mortgages: Take Advantage of These Low-Rate Mortgage Loans to Buy a New Home
Are you thinking about buying a home in a rural or suburban area? If so, you'll want to take a look at the United States Department of Agriculture's mortgage programs as you may qualify for them.
In today's blog post we'll introduce the USDA Rural Development Single Family Housing Guaranteed Loan Program, explain the benefits of this mortgage program and how to determine if you qualify.
What is a USDA Mortgage Loan?
The USDA mortgage program is one of a number of programs in which the federal government will guarantee a mortgage loan as long as the recipient meets certain criteria. The intent of this program is to provide a boost to residents of rural or suburban areas who are struggling to obtain a traditional mortgage.
USDA mortgage loans are an ideal solution for those who are looking for 15 or 30-year amortization periods as they tend to have lower interest rates than mortgages offered by banks and other lenders.
USDA Mortgage Loan Benefits
There are numerous benefits to USDA mortgages that make this an enticing option compared to a mortgage from a traditional lender. As these loans offer full 100 percent financing you won't have to place a large down payment when buying the home. The USDA offers very competitive 15 and 30-year fixed interest rates, something you won't find from many banks or other mortgage lenders.There's also no maximum home purchase price with USDA mortgages, however note that you'll still be limited by your risk and your ability to manage the monthly mortgage payment.
USDA Mortgage Loan Requirements
The USDA mortgage program is open to all homebuyers that meet a number of initial requirements. The home you intend to purchase has to be located in a rural area (as determined by the USDA) and it cannot be a vacation home or investment property. As with any mortgage, you'll need a relatively clean credit history. Finally, note that your annual income will also be assessed and you'll need to prove that you're within 115 percent of the region's median income.
As you can see, the USDA Rural Development Mortgage program can be an excellent option if you're planning on buying a home in a rural or suburban area. Contact your local mortgage advisor today and they can explain the USDA home loan program and answer any questions that you might have.
November 21, 2014 by Ann Zeilingold · Leave a Comment
FOMC Minutes: Economy Growing, Housing Lags
Minutes of the Federal Open Market Committee (FOMC) meeting held October 28 and 29 were released Wednesday. The report suggests that the U.S. economy continues to improve, although the annual inflation rate remains near 1.50 percent and short of the committee's goal of 2.00 percent. Falling crude oil prices were cited as a cause of faltering inflation rates. The minutes indicated that FOMC members expect inflation to remain below the 2.00 percent benchmark for the next year or so.
The minutes did not reveal an exact date for raising the target federal funds rate, which is currently 0.00 to 0.250 percent, but analysts expect a rate change in mid-to-late 2015. One committee member said that the Fed should commit to keeping the target federal funds rate at its present level until inflation reaches the Fed's goal of 2.00 percent.
Job Markets Improve, Mortgage Rates Fall
FOMC members said that labor markets had improved "somewhat further." The minutes noted that the national unemployment rate had declined to 5.90 percent in September, which was lower than the FOMC goal of 6.50 percent for national unemployment. While this was good news, FOMC discussed the fact that a significant number of part-time workers suggested under-utilization of the labor force. A combination of stronger labor markets and a 0.25 percent reduction of mortgage rates during the intermeeting period between September 17 and October 28 were seen as positive for housing markets, but the committee noted that mortgage lending standards for single-family homes had not changed much. Lending requirements were more accommodative for commercial real estate.
QE Ends, FOMC Seeks to Maintain "Accommodative" Financial Conditions
FOMC members voted to end asset purchases made under the Fed's quantitative easing program, but said that ongoing reinvestment of principal payments on bonds and MBS with the goal of maintaining "sizeable" holdings of long-term securities. The minutes indicated that this would help maintain "accommodative" financial conditions.
The committee agreed to re-assert its position that although national unemployment and inflation may achieve or surpass FOMC goals, the committee could maintain the target federal funds rate at current levels for "some time" after the benchmarks are achieved. Ultimately, the FOMC's decision to change the target federal funds rate will include thorough and ongoing review of global and domestic economic developments.
Committee members concluded this meeting with a decision to set the next FOMC meeting for December 16 and 17.
November 20, 2014 by Ann Zeilingold · Leave a Comment


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How Police Officers Are Trained to Know Which of Your Belongings Are Most Worth Seizing
Police officers are trained to know what property of yours makes the most sense to seize. The Heritage Foundation has written much about a law… Read More
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text:
I love how he says "second" instead of "minute" and the right wing labels him a fool. Have you listened to a word either of the Bushes have said?
via Facebook http://bit.ly/1aMHJcG
Civic Lesson
I said what?!
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- RT @WhatTheFFacts: Colorado switched mile marker "420" to "419.99" to stop people form stealing it. http://t.co/XrdogqpvM4 6 hours ago
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The James F. and Marion L. Miller Foundation, Meyer Memorial Trust, The Collins Foundation, The Paul G. Allen Family Foundation, William G. Gilmore Foundation, The Maybelle Clark Macdonald Fund, Maribeth Collins Exhibition Endowment Fund, Sharon and Keith Barnes, Pat and Trudy Ritz, Arlene Schnitzer/The Harold & Arlene Schnitzer CARE Foundation, Larry and Jane Viehl, The Standard, Mary C. Becker, Flowerree Foundation, The Wheeler Foundation, Exhibition Series Supporters, Virtual Information Executives, GridBox Media, Portland Monthly, NW Natural, Ziba Design, Oregon Arts Commission, The Regional Arts & Culture Council, Work for Art, and Anonymous (2).
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"Spending today complaining about
yesterday won't make tomorrow better."
Chat about the latest Ipods and talk about the latest gadgets with your friends. What is your favorite electronic gadget?
"Spending today complaining about
yesterday won't make tomorrow better."
teh nostalgia
Want advice? Ask me, or look at my blogs.
Ask me about anything and I'll try to help you as much as I can :'D
"You can't start the next chapter if you keep re-reading the last"
teh nostalgia
"pokeman4ever" wrote:why less portable? please explain i was thinking about getting one.
A great online version of the famous Candy Crush. This is the best game launched...
Have you ever fancied being a ranger like those fantasy characters you love so m...
Millions of Students will be doing an Hour of Code with Tynker December 8th-14th...
You run across the city in a car chase with the police officers.
The evil master kidnapped all of your friends!


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1937 Jaguar SS 100 Roadster Replica Great looking replica of an iconic British sports car from the Golden Age of European performance cars. ... More
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text:
"I told the guys we're not in this thing to knock anybody out. I don't care if the Yankees or the Red Sox get in. I care about the Baltimore Orioles. But we're in this thing, and people are watching for two weeks. We have a chance to play some good baseball and feel proud about it."
Related quotes
"Yankee Stadium is my favorite stadium; I'm not going to lie to you. There's a certain feel you get in Yankee Stadium."
"I just picked up the phone. Actually, it was not that easy. I called Yankee Stadium, and they gave me a number of a person in Dallas that handled all his relationships."
"I still think the division and league are wide open. It's not like the American League, with the Yankees and Boston, or Chicago, who are all extremely stacked."
"The one I fought the best was the last one at Yankee Stadium. After 15 rounds I was not tired and felt I could've fought 15 more."
"Of course we watch what the Yankees do, ... but our feeling is they're an island in the game. We're not going to compete with their payroll or revenues. We expect that this team will have a lot more fun than last year's, doing it quietly, without a $180 million payroll."


text:
Pearls in autoimmunity
ABSTRACT This manuscript does a review of the more frequent issues published at Autoimmunity Reviews, Journal of Autoimmunity and Autoimmunity
in the period of January–December 2009. The following topics were commented: (1) multiple sclerosis (MS) and its relationships
with Epstein Barr infection, with vitamin D polymorphism and the new modalities of MS treatment. (2) Type 1 diabetes and genetic
discovers, studies with GAD 65 and IA-2 autoantigen and the association T1D and autoimmune organ-specific diseases. (3) Autoimmune
thyroid disorders and its association with susceptibility genes and polymorphisms. (4) Multiplex autoantibody profiling approaches
in MS and rheumatoid arthritis. (5) Th17 cytokine in primary biliary cirrhosis, experimental autoimmune encephalomyelitis
and celiac disease. (6) Vitamin D and experimental autoimmune prostatitis and pulmonary alveolar proteinosis.
KeywordsAutoimmunity–Multiple sclerosis–Diabetes–Thyroid disorders–Vitamin D–Autoantibodies
Article: Hair dyes as a risk for autoimmunity: from systemic lupus erythematosus to primary biliary cirrhosis[Show abstract] [Hide abstract]
ABSTRACT: Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium sized intrahepatic bile ducts. Environmental factors include exposure to various infectious, xenobiotic and chemical compounds. These exposures may occur occupationally, through water or air contamination, pharmacological administration or by elective exposure, to name a few. Hair dyes are compounds that have been implicated in the development of several autoimmune diseases, including systemic lupus erythematosus (SLE) and PBC. So far, only epidemiological studies have addressed the role of hair dyes in PBC, with limited results. Hair dyes in SLE have been examined, and have recently demonstrated an association, both epidemiologically and immunologically. This follows a series of negative studies, which may not have taken into account several features of hair dye use. This review will examine the literature surrounding hair dye use and SLE, and compare this to data surrounding PBC. Treating physicians should be prepared for questions surrounding the need to take precautions against repeated hair dye use and this topic is discussed further.Autoimmunity Highlights. 01/2013; 4(1).
Page 1
Pearls in autoimmunity
Joze ´lio Freire de Carvalho•
Rosa Maria Rodrigues Pereira•
Yehuda Shoenfeld
Received: 2 January 2011/Accepted: 11 January 2011/Published online: 23 March 2011
? Springer-Verlag 2011
Autoimmunity and Autoimmunity in the period of January–
December 2009. The following topics were commented: (1)
multiple sclerosis (MS) and its relationships with Epstein
Barr infection, with vitamin D polymorphism and the new
modalities of MS treatment. (2) Type 1 diabetes and genetic
association T1D and autoimmune organ-specific diseases.
(3) Autoimmune thyroid disorders and its association with
susceptibility genes and polymorphisms. (4) Multiplex
autoantibody profiling approaches in MS and rheumatoid
arthritis. (5) Th17 cytokine in primary biliary cirrhosis,
experimental autoimmune encephalomyelitis and celiac
disease. (6) Vitamin D and experimental autoimmune pros-
tatitis and pulmonary alveolar proteinosis.
This manuscript does a review of the more fre-
Diabetes ? Thyroid disorders ? Vitamin D ?
Autoimmunity ? Multiple sclerosis ?
PubMed searches include only the following periodics:
Autoimmunity Reviews, Journal of Autoimmunity and
Autoimmunity, this manuscript did a review of the more
frequent issues published in the period of January–
December 2009.
The following topics will be herein summarized:
(a) multiple sclerosis (MS) and its relationships with
Epstein-Barr infection, with vitamin D polymorphism and
the new modalities of MS treatment. (b) Type 1 diabetes
(T1D) and genetic discovers, studies with GAD 65 and IA-
2 autoantigen and the association T1D and autoimmune
organ-specific diseases. (c) Autoimmune thyroid disorders
and its association with susceptibility genes and polymor-
phisms. (d) Multiplex autoantibody profiling approaches in
MS and rheumatoid arthritis. (e) Th17 cytokine in primary
biliary cirrhosis, experimental autoimmune encephalomy-
elitis and celiac disease. (f) Vitamin D and experimental
autoimmune prostatitis and pulmonary alveolar proteinosis.
Multiple sclerosis
The literature brings the idea that vaccination against
Epstein-Barr and also antiviral treatment of this condition
could inhibit the progression or else cure multiple sclerosis
(MS) originates from the fact of that more than 99.5% of
the patients with MS are positive for Epstein-Barr virus
(EBV) serology as compared to 94.0% of controls [1].
Pender proposes an autoimmune hypothesis that EBV-
infected autoreactive B cells attack the target organ where
they produce pathogenic autoantibodies and provide
costimulatory survival signals to autoreactive T cells, in
genetically susceptible people [2, 3]. In agreement with this
J. F. de Carvalho (&) ? R. M. R. Pereira
Rheumatology Division, Disciplina de Reumatologia, Faculdade
de Medicina, Universidade de Sa ˜o Paulo, Av. Dr. Arnaldo 455,
3? andar, Sala 3105, Sa ˜o Paulo, SP 01246-903, Brazil
e-mail: email@example.com
Y. Shoenfeld
Department of Medicine B, Center for Autoimmune Diseases,
Sackler Faculty of Medicine, Sheba Medical Center, Tel-Aviv
University, Tel-Hashomer, Israel
Y. Shoenfeld
Incumbent of the Laura Schwarz-Kipp Chair for Research
of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel
Autoimmun Highlights (2011) 2:1–4
DOI 10.1007/s13317-011-0016-x
Page 2
pathophysiology, Fraussen et al. [4] demonstrated that
autoreactive B lymphocytes are detected in MS cerebro-
spinal fluid, and these cells are responsible for the immu-
noglobulin production and oligoclonal band formation seen
in this neurological disorder, in comparison with healthy
people where these B cells are not observed.
Another mechanism associated with MS pathophysiol-
ogy is the vitamin D status. In this line, polymorphisms of
the active metabolite vitamin D receptor (VDR) have major
effects on vitamin D function and its metabolism, as well
as on immune regulation. Indeed, in a recent study, the
authors concluded that the VDR plays a role in the regu-
lation of vitamin D metabolism in MS patients and in
healthy controls, and that the Fok-I polymorphism affects
this regulation [5]. Furthermore, other studies show a sig-
nificant difference of genotype distribution frequency
between the MS patients and controls for the functional
exon 9 VDR marker Taq I and for the Apa I alleles [6].
Regarding treatment, as the available immunomodula-
tory therapies for MS patients are only slightly effective
and do not avoid the progression of neurological deficits,
Payne et al. [7] reviewed the possibility of using new im-
munomodulators that act on degraded myelin growth
inhibitory molecules and neuroregenerative therapies (e.g.
stem cell therapy), or the combination of these modalities.
These experimental treatments appear exciting, although
much labor is still needed to make certain their long term
safety and efficacy.
Type 1 diabetes mellitus
Type 1 diabetes (T1D) is a genetically conditioned auto-
immune disease in which several polymorphisms genes
have been described. Recently, Settin et al. [8] studying
cytokine-related polymorphisms demonstrated association
to TNF-a and IL-1Ra genes among Egyptians diabetic
patients and suggest that these polymorphism could be
considered as genetic markers for T1D.
Another interesting genetic study showed that the
PTPN22 polymorphism is associated to T1D exclusively in
children exposed to cow's milk during early infancy
(before the age of 6 months) suggesting a relationship
between genetic and environmental factors [9]. A Japanese
study demonstrated that a FOXP3/Scrufin polymorphism
was associated with adult onset T1D, especially in females,
and slowly progressive T1D. This gene alteration could be
implicated with a regulatory T cells dysfunction [10].
HLA-class II genes are also implicated in susceptibility
for human T1D. Elagin et al. [11] demonstrated in an
animal model in the context of human HLA-class II dia-
betes-susceptibility genes, that immunization with a human
autoantigen (GAD65) results in the development of a
severe insulitis and low levels of autoantibodies. These
authors bring a new animal model which helps studies on
GAD65 autoimmunity in the scenario of HLA-DR8.
Most T1D mellitus is caused by autoimmune pancreatic
beta-cell destruction and various antigens are implicated in
this process such as, glutamic acid decarboxylase-65
(GAD65), islet cell antigen (IA-2), insulin, and islet-
specific glucose-6-phosphatase catalytic subunit related
protein. Investigating the role of the GAD65, Kanazawa
et al. [12] using GAD65 knockout non-obese diabetes
(NOD) splenocytes and transferring to NOD–SCID system,
the authors observed that the onset of diabetes in recipients
of knockout splenocytes was significantly delayed as
compared to recipients of wild-type splenocytes. This study
suggested that anti-whole GAD65-reactive T cells have the
ability to regulate the development of T1D.
The role of GAD65 was recently evaluated using a
hydroxyl radical modified antigen. The ROS oxidation of
GAD65 caused conformational perturbation, generating
highly immunogenic neoepitopes. The authors concluded
that this neoantigen could be one of the factors to induce
T1D autoantibodies [13].
Another work studying the epitopes of the IA-2 auto-
antigen, the authors identified a region of IA-2 (831–860)
frequently recognized by antibodies in T1D and demon-
strates that these responses stimulate T cells to produce
interleukin-10 [14].
Type 1 diabetes could be associated with other auto-
immune disorders such as thyroid disease, autoimmune
gastritis, celiac disease and Addison's disease. Tsirogianni
et al. [15] suggested screening organ-specific autoanti-
bodies in diabetic patients in order to detect early devel-
opment of these associated autoimmune diseases.
Three additional articles concerning this field were also
published at Journal of Autoimmunity [9, 11, 14].
Thyroid disorders
Various susceptibility genes, including HLA, for autoim-
mune thyroid diseases have been identified. HLA-DR3 has
been described strongly associated with Graves' disease
(GD) and the frequency of this HLA was generally 40–55%
in GD patients, compared to 15–30% in the general
population, resulting in a relative risk for people with
HLA-DR3 of 3–4 and recent studies have suggested that the
primary susceptibility allele in GD is indeed HLA-DR3
(HLA-DRB1*03) [16]. Very recently, an arginine substi-
tution at position 74 of the DR b 1 chain of HLA-DR3
(DRb1-Arg74) has been described to be associated with
GD and also related to thyroglobulin variants. This amino
acid substitution originates a significant deforming in the
peptide binding pocket of HLA-DR, affecting the binding
2Autoimmun Highlights (2011) 2:1–4
Page 3
of pathogenic thyroid peptides. This knowledge brings
new ideas regarding treatment using antagonist agents or
peptide to HLA-DR modulation [17]. On the other hand,
non-HLA genes including the CTLA-4, CD40, PTPN22,
thyroglobulin, and TSH receptor genes has been also
implicated in autoimmune thyroid disease [18].
Interleukin-23 receptor single nucleotide polymor-
phisms has been related with Graves' oftalmopathy (GO).
In a case control study with North American Caucasian
subjects, the A allele of rs2201841 was demonstrated to be
strongly associated with GO [19] although this genetic
alteration was not observed in Japanese individuals [20].
Regarding clinical studies, our group have demonstrated
for the first time in juvenile onset of systemic lupus ery-
thematosus that thyroid disorders are associated with a
mild lupus presentation in comparison to those patients
without this endocrinological disease [21].
Multiplex autoantibody profiling approaches
Multiplex arrays are one of the technologies which are able
to detect autoantibodies by measuring simultaneously
thousands of markers from a unique biological sample. The
main rationale of diagnostic tests is making an early and
accurate diagnosis, however it increases the probability of
false positive and false negative results.
Application of this technology has been recently used in
MS using a autoantibody profiling with promising results
regarding the generation of a so-called MS-specific auto-
antibody fingerprint. Somers et al. [22] applied this tech-
nique for MS cerebrospinal fluid identified a new panel of
eight antigenic targets with 45% sensitivity and 86%
specificity for this neurological autoimmune disease.
Since antibodies directed to citrullinated peptides (anti-
CCP) showed a similar sensitivity but a more elevated
specificity than the rheumatoid factor (RF), a multiplex
approach to detect RF in combination with ELISA anti-
CCP test was recently evaluated in patients with rheuma-
toid arthritis to increase the sensitivity of RF. The authors
could observe in a prospective study that multiplex cyto-
fluorimetric test appeared to be more sensitive and specific
than nephelometric assay for RF detection [23].
Interleukin-17-secreting T cells (Th17)
The emerging role of interleukin-17 as an important pro-
inflammatory cytokine, produced primarily by a new T
helper cell subset termed Th17, has received significant
interest in the pathogenesis of several human autoimmune
diseases and animal models of autoimmunity. Differentia-
tion of Th17 cells is driven by the simultaneous presence of
transforming growth factor-beta (TGF-beta) and some
inflammatory cytokines (IL-6, IL-21) [24].
The Th17 role in the pathophysiology of primary biliary
cirrhosis (PBC) was demonstrated in a recent study using
human and murine model of this disease. The authors
found an increase in the frequency of positive IL-17 T
lymphocytes in liver tissues from PBC patients, and also
increased IL-17 production in mice cocultures of splenic T
cells and in liver non-parenchymal cells, suggesting a role
of the Th17 in liver autoimmunity [25].
This cytokine was also studied in experimental auto-
immune encephalomyelitis (EAE). The authors evaluated
the role of thrombospondin-1 (TSP-1), a protein that could
be implicated in the production of IL-17 through TGF-beta
activation of TGF-beta, on the generation of an encepha-
litic Th17 response in EAE. This study demonstrated that
TSP-1 participates in the differentiation of Th17 cells
through its ability to activate latent TGF-beta, and enhan-
ces the inflammatory response in EAE [26].
This Th17 cytokine has also been studied in intestinal
biopsies from celiac disease patients with active disease,
remission disease and those after in vitro gliadin exposi-
tion. Potent Th17 responses were observed in active dis-
ease, whereas short incubation with gliadin of biopsies
showed a tendency of upregulation of Th17, suggesting a
importance of Th17 in active phase of celiac disease [27].
Vitamin D and autoimmunity
Vitamin D has effects in modulating the immune response
including inhibitory effects on T cells, B cells and dendritic
cells and these suppressive immunologic properties have
led to considering its role in autoimmune and inflammatory
diseases. In this way, the impact of VDR on experimental
autoimmune prostatitis has been recently investigated using
of VDR-Knockout mice. These knockout animals presented
a more severe prostatitis with a higher lymphoproliferative
response against prostate antigen and amplified levels of
interferon c associated with an augmented of mononuclear
cell infiltration. The authors concluded that VDR plays a
role in pathophysiology of autoimmune prostatitis [28].
Pulmonary alveolar proteinosis (PAP) is an autoimmune
disorder characterized by surfactant accumulation and
neutralizing autoantibodies, granulocyte/macrophage col-
ony stimulating factor, and deficiency of activin A (a
cytokine implicated in regulating B-cell proliferation in
alveolar macrophage). Recently studies also demonstrated
deficiency in vitamin D target in bronchoalveolar lavage
from these patients. A study investigated the effects of
1,25-dihydroxyvitamin D on activin of the macrophage
alveolar from PAP and healthy subjects demonstrated that
vitamin D increased activin A only in healthy controls but
Autoimmun Highlights (2011) 2:1–43
Page 4
not in PAP patients. A deficient expression of vitamin D
target genes (cathelicidin and thioredoxin interacting pro-
tein) was also observed in macrophages of PAP patients,
suggesting that an impairment of activin expression may
involve dysregulation of a novel species-specific vitamin
D-activin A pathway in PAP [29].
recipients of grants from the Federico Foundation and CNPq (300665/
2009-1 to JFC and 305691/2006-6 to RMRP).
J.F. de Carvalho and R.M. Pereira were the
Conflict of interest
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multiple sclerosis. Part I: the role of infection. Ann Neurol
2. Pender MP (2003) Infection of autoreactive B lymphocytes with
EBV, causing chronic autoimmune diseases. Trends Immunol
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Gene polymorphisms of TNF-alpha-308 (G/A), IL-10(-1082)
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Carvalho JF, Pereira RM (2009) Juvenile onset systemic lupus
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RL, Gershwin ME (2009) Hepatic IL-17 responses in human and
murine primary biliary cirrhosis. J Autoimmun 32:43–51
26. Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B,
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Abraham S, Singh RJ, Brescia D, Kavuru MS, Thomassen MJ
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4Autoimmun Highlights (2011) 2:1–4


text: In Pictures: The best office apps for your iPad, round 4 Be sure to have these apps to get the most office productivity possible from your iPad Galen Gruman (InfoWorld) 0 - - - - print email prev next Loading... Presentation editor: KeynoteSimply put, Keynote is an amazing slideshow editor. I prefer it over PowerPoint even on the Mac, and on the iPad, it works beautifully when creating complex slide transitions and element effects. And its iCloud compatibility can be a real life-saver, ensuring all your devices have the current documents. A bonus is Apple's free Keynote Remote app for the iPhone and iPod Touch that lets you control a Keynote presentation remotely on your Mac or iPad.Keynote's big negative is its awkward requirement of copying documents to and from cloud storage services, rather than allowing direct access as other apps do. Prev Next 6/15 Comments on this image There are currently no comments for this image. Comments are now closed. Close In Pictures: The best office apps for your iPad, round 4 15 images


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You can now filter search results with text. Example: "person: john" will search only person pages for "john".
Can Barry Allen still save the day without his super speed?
John Constantine's plan has seemingly failed and now nothing is holding Superman back.
"I have you now," said the Inquisitor to Kanan and Ezra.
Character »
Possessor appears in 26 issues.
A mutant and original member of the X-Men. Warren received his angelic wings at a tender age, as well as a unique healing factor in his blood. After being twisted into a weapon of Apocalypse, Warren became the cold Archangel.
Former KGB agent Natasha Romanova, known as Black Widow, is one of the greatest spies ever and is one of the best agents S.H.I.E.L.D. has ever had. She's a long-time member of the Avengers and was a founding member and the only leader of the short-lived Los Angeles-based superteam: The Champions.
The first Darkstar, Laynia Petrovna is a mutant capable of manipulating an immeasurable amount of darkforce energy. She lived and died in service to her mother country Russia, but was later resurrected in the body of the previous Darkstar, Reena Stancioff, when Reena was transformed into a Dire Wraith.
Nova fought the Elders of the Universe when they tried to kill Galactus
Galactus is the famed "Devourer of Worlds" in the Marvel Universe. His powers are nearly omnipotent. He has appointed a number of entities as his Heralds, imbuing them with the Power Cosmic. He uses energy from the core of planets and universal sources to sustain himself. Only a select few beings have defeated him such as Phoenix Force.
Denying his infernal heritage, the Son of Satan uses his abilities for the betterment of mankind, but has at times succumbed to his darker, demonic side, even clashing brutally with the forces of both Heaven and Hell.
Hercules first met Kamo Tharnn, the Elder of the Universe known as the Possessor, while on a quest to obtain the Rune Staff. The Rune Staff is the chosen power item/talisman of the Possessor. Upon finding the staff in the Kamo Tharnn's possession, Hercules and his companion Sif, the Asgardian warrior-maiden love interest of his friend Thor, battled the Possessor and eventually obtained the Rune Staff which they brought back to Earth and used to to aid Thor.
The youngest member of the original X-Men. Bobby is an Omega-level mutant, although it took some help from Emma Frost to realize this. Bobby's control of ice is vast; he can create shields, clones, spikes, slides and also freeze others. He currently teaches at the Jean Grey School for Higher Learning.
Once allies in his realm, In-Betweener betrayed them and called Death to dispose of them
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Thor is the Asgardian God of Thunder and the son of Odin, the All-Father of Asgard , the Elder Earth-Goddess. Combining the power of both worlds, Thor is arguably the greatest and mightiest defender of both . Armed with his powerful enchanted hammer Mjolnir, Thor is the mightiest warrior of Asgard, a founding member of the Avengers and one of the strongest, most powerful beings on Earth.
One of the Wild West's most famous gun-fighters, Two-Gun Kid journeyed forward to modern times alongside the Avengers to face new challenges as a man out of time.
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Until then, gain points by continuing to edit pages.
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