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- Address:
Evansville, IN 47713Neighborhood:
- Cuisine:
Fusion / EclecticPrice: $31 to $50
- Dining Style: Casual Elegant
- Website: http://www.madeleinesfusion.com/
- Phone: (812) 491-8611
- Hours of Operation:
Dinner: Tuesday - Thursday: 4:30pm - 10:00pm, Friday & Saturday: 4:30pm - 10:30pm
- Payment Options: AMEX,MasterCard,Visa
- Cuisine: Fusion / Eclectic, Global, International
- Executive Chef: Timothy Mills
- Dress Code: Smart Casual
- Accepts Walk-Ins: Yes
- Additional Details: Banquet/Private Rooms, Bar Dining, Bar/Lounge, Beer, Chef's Table, Dancing, Fireplace, Full Bar, Late Night, Non-Smoking Area, Non-Smoking Restaurant, Patio/Outdoor Dining, Private Room, Smoking Area (patio only), Takeout, View, Wheelchair Access, Wine
A word from Madeleine's
Madeleine's, located in the heart of the Historic District, is Evansville's only Fusion Restaurant. Chef Timothy Mills, of The Culinary Institute of America, and Tyra Sikkink named their casual elegant restaurant in honor of their daughter Madeleine. Chef Mills brings his experience from around the country, including New York and Washington, D.C. to the Tri-State. The menu changes weekly and features the freshest seafood and choice meats combined with a fusion flair that makes your dining experience truly unique and pleasurable every time. Our wine cellar houses the Tri-State's finest selection of premium wines, while our bar features numerous premium liquors and a fusion specialty, Sake Martinis. Whatever the occasion, a romantic dinner, dinning with friends, business entertainment, or just a love of fine food, Madeleine's is sure to pleaseContinued
Foodspotting photosSee all photos
Awards voted by OpenTable diners
- Diners' Choice WinnerMost Booked
Madeleine's - Best Restaurants in Evansville ›
Madeleine's reviews from OpenTable diners
36 reviews since August 1, 2014
- Food4.6Service4.5
- Ambiance4.5Noise LevelModerate
romantic (26)neighborhood gem (25)special occasion (24)fit for foodies (19)notable wine list (19)great for outdoor dining (8)good for groups (4)late-night find (4)hot spot (2)kid-friendly (1)Show More
- Our favorite place in EvansvilleSean7371Dined on 10/31/2014My wife and I recently moved to the tri-state from Nashville where it seems like a great restaurant opens up almost every day, and I am convinced that Madeleine's could hold its own against any of those places. It is quickly becoming not only our favorite restaurant in Evansville but anywhere for that matter!Special Features:
- A pleasant birthday dinnerDino47Dined on 10/24/2014A nice fall evening, that was made nicer by the wonderful dinner at Madeleines. Fish and chicken with a great pinot grigio from Napa. Ice cream and coffee finished the meal perfectly.Special Features:I would recommend this to a friend.
- #1 in Evansville AreathefourbeesDined on 10/15/2014After dining at just about every restaurant in the area in the past 2 years, we discovered that Madeleine's is the best so far. I don't know why we waited so long to try it but we're glad we did and we plan to return soon. I would compare the whole experience to one of the best experiences we had in New Orleans. We tried the fish, ravioli, chicken and the largest pork chop we've ever seen. The food was superb. The service was very attentive and professional. Very charming and lovely atmosphere.Special Features:I would recommend this to a friend.
- WonderfulCrashDined on 10/11/2014My bride and I had a perfect dining experience at Madeline's for our wedding meal. We were given a private table and the food, service, and ambiance was absolutely spot-on. We couldn't have asked for anything more. Thank you so much for adding to our special day.Special Features:
- European FeelLittleasyDined on 10/10/2014My wife and I went there for a nice romantic dinner. The have a very fresh menu that changes weekly or as local items are available. Everything is cooked fresh with fresh products and with care, skill and attention. They have a very good wine list and an extremely selection of your bar liquors. If you are looking for a Coors Light with your dinner you just came to the wrong spot! Nothing they have pairs with Coors Light and that is a great thing. The dining room gave you the feel of being in a small french restaurant with the tables, not matching chairs and same for the flat-ware. Just a really great meal, great atmosphere, great service! Very surprising to find such a spot in Evansville. We will be back.Special Features:
- Loved it!spunkyDined on 10/4/2014We are from out of town but will be coming back to Madeleine's.Special Features:
- Lovely mealqualitymattersDined on 10/2/2014Service, ambience and food were very good. Each entrée that our party of four ordered exceeded expectations.Special Features:
- OpenTable Diner Since 2009Dined on 10/2/2014Excellent meal with great blue cheese gnocchi. Excellent bar!Special Features:
- Good food, longggggg dinnerYouknowmeDined on 9/26/2014This was a great place for a romantic evening. We arrived 10 minutes prior to our reservation to an EMPTY restaurant and patio. We were surprised by this, especially on a Friday night. We ordered the cheese plate (DELICIOUS) and the suggested wine. We also had the lobster ravioli, filet & mushrooms... all very good. We also ordered dessert, I enjoyed my apple pie? (not sure it was really pie, more of an apple crisp..) but my husband did not enjoy or find anything special about the Banana's Foster. Our only gripe was that it took us OVER three hours from sitting down to leaving. We enjoyed our quiet evening away but it took a lot longer than expected!Special Features:I would recommend this to a friend.
- What a great find.Davin1023Dined on 9/26/2014My wife and I loved this place! We went very early so it was quiet and empty, but the food was truly amazing.Special Features:
- What a gem in out of the way spotGahuskerDined on 9/25/2014We are from out of state (Georgia) - actually learned about this from Arizona friends who had a referral from Indianapolis. That's quite a reputation. We met Tim - what a wonderful experience; he visited us at our table and sincerely wanted our feedback regarding the overall experience. We were effusive with our compliments (we've eaten at 5-star restaurants from coast to coast) - food, staff and service were all outstanding. The neighborhood initially made us think we were lost - alas! His establishment is a hidden gem and well worth the visit. Everyone we encountered during our dining experience were 1st class and very service oriented. We highly recommend and will also return if we are in Evansville again.Special Features:I would recommend this to a friend.
- great saladsbirthdayDined on 9/23/2014The salads ( beet and heirloom tomato) were great. The entries were also good, Osso Buco and pork chop. nice evening for my wife's birthday.Special Features:
- First Class ExperienceOpenTable Diner Since 2014Dined on 9/3/2014This place stands out from the ordinary. The minute you walk in the door you can feel the calm and warm atmosphere. The level of personal attention and caring invite you into an evening with new friends. The wine list is unmatched in the area and the food is a treat to see as wlll as enjoy for every option from start to the wonderful deserts. An enjoyable event every time I get to visit.Special Features:
- Jewel On the Ohio.BeardsleyVIPDined on 9/3/2014What a find! I love happening on one-of-a-kind Single-Propriator locations known for "something" whether a dive diner or a high-end dining experience. Madeleine's is the latter. Nestled in Evansville's Historic district among turn of the century homes its easy to drive by even if youre looking for it. The food, ambiance and wine were exceptional. While a choice between Prime and Dry Aged beef was a nice touch one doesn't expect to find a Calamari Tender preperation of this quality in a quaint Ohio River Town setting. Madeleine's will be my default choice whenever my travels take me to Evansville in the future.Special Features:
- Great nite outCarlDined on 8/28/2014Very timely and knowledgeble staff, calamari excellent and very unique, steak was as good as I've had any where. It was a very cool evening trying creative mixed drinks and hanging out with friends on the very cool patio after dinner.Special Features:I would recommend this to a friend.
- Dinner at Madeleine'sWinenDineDined on 8/28/2014My wife and I had our 26th anniversary at Madeleine's this past Thursday evening. Emma was our waitress and she was Great! I had the bone-in Ribeye MR and it was cooked to perfection! Very Good! My wife ordered the Frog Leggs and she was not quite as satisfied with her meal. Wine choice was The Prisoner......very good. Recommend this place for sure.........Special Features:I would recommend this to a friend.
- Somewhat disappointing for a FusionOpenTable Diner Since 2014Dined on 8/20/2014Located in the historic district of Evansville, everything was tastefully done, except for the food and the service. The food was good but not great, and the server, although attentive, served us the wrong entree and failed to bring us a side dish that we ordered. The prices seemed a bit high for what we received. Since you have to go out of your way to get there, you should probably find out from others, who are familiar with the restaurant, what dishes are worth ordering.Special Features:
- DukeDukeDined on 8/15/2014Madeleine's provided a quiet dinner for my wife and I to enjoy our anniversary. We were seated immediately when we arrived. The duck was fantastic. The rack of lamb was just average. The outdoor seating was romantic and comfortable. A very nice dinner with good service and great food.Special Features:I would recommend this to a friend.
- Perfect Birthday CelebrationCuriousDiner88Dined on 8/15/2014I booked Madeleine's to celebrate my best friend's birthday and my own to top off our girl's day. It was perfect from the moment we sat down. I had asked if they did anything special for birthdays to include it. I was presently surprised to find the table decorated with birthday items. It was sweet. Our waitress was perfect. Attentive and knowledgeable about the menu. The food was delicious from start to finish. I just wish I had enough room to finish the Vidalia Onion soup. Yum! My friend enjoyed her meal as well. It's the perfect spot for friends looking for a higher-end birthday celebration, a romantic date, an anniversary or just wanting something different.Special Features:I would recommend this to a friend.
- IndyvisitorsDined on 8/9/2014Wonderful meal, especially enjoyed the duck. Great desserts! Great saki style martinis! What a neighborhood gem!Special Features:I would recommend this to a friend.
- The following 161 reviews are from the Madeleine's reviews archive.
- steaknutsforsteakDined on 7/22/2014The steak was over cooked. However, it was still very good. Very large portions.Special Features:I would recommend this to a friend.
- Wonderful Find!!!!!RoosterDined on 7/12/2014Went to Madeleine's for a second first date in 25 years. Right off the bat the Chef Tim greeted us, Corey the mixologist poured a generous glass of wine and Sadia our server was very pleasant and personable. The food was great, the wine list extensive and the atmosphere was outstanding. The restaurant closes at 10 but we went out back to the outdoor dining area after dinner and stayed until 1 or maybe 2...we lost track of time. Tisha (?) Tim's wife and Madeleine (their daughter) came out and we had a wonderful conversation. This is definitely a wonderful place to come and enjoy food...A diamond in the rough in Evansville, IN of all places. PS-I went with a lifelong resident of Evansville and this was their first time....Loved It!!Special Features:I would recommend this to a friend.
- A "gem" of a place.HobinDined on 7/12/2014Not what you would expect in a city like Evansville where chain restaurants dominate. I have not been disappointed the 3 times I have frequent. Still lovin' the Lobster Mac n' Cheese and the vanilla cheese cake was sooo yummy !Special Features:I would recommend this to a friend.
- lovely placeEmilyDined on 6/24/2014We were on vacation with the kids going to Holiday World during the day and eating well at night. Madeleine's was by far one of the best places we've eaten. The sweetbreads were unbelievable. The duck was delicious. They made the very best chicken fingers for the kids that I've ever had. The wine was amazing. Dessert was ok. Or was not the strongest dish of the night but certainly good. The ambience was amazing and the owner was especially kind to our children who are well behaved but at 6and 4, young all the same. A big recommendation for this neighborhood gem.Special Features:I would recommend this to a friend.
- FabulousMrandmrsHDined on 6/21/2014We have found a gem! Great food friendly owners, great wine list. Beautiful surrounding with the greatest collectic silverware and plates. I can't wait to bring more of our friends.Special Features:I would recommend this to a friend.
- Great find in a little town...familyfoodiesVIPDined on 6/21/2014This was our second time at Madeleine's and we really enjoyed dinning there. Our kids are in competitive swimming and we travel to Newburgh/Evansville once a year in the summer time. The particularly outstanding dishes of the night were the deviled eggs with the watermelon relish, the rabbit in a mushroom cream based sauce and the vanilla cheesecake. The waitress was very accommodating taking care of our kids (10 and 12) who enjoyed the grilled salmon with a side of one of the best mac and cheese I ever tried. The place is a little quiet and more on the romantic side for a family with young children. We highly recommend it for a special occasion and its historical location!Special Features:I would recommend this to a friend.
- Elegant DiningTravellerDined on 6/18/2014The owner has demonstrated pure genius in creating the perfect setting. Great venue with delicious food. Makes me want to move to Evansville. Ah well, Maybe Madelein's will come to us.Special Features:I would recommend this to a friend.
- Creative menuIndytimVIPDined on 5/29/2014Menu frequently changes with one creative dish after another. Always perfectly spiced and prepared. Seafood, steaks, lamb and poultry are always top quality.Special Features:
- Fine diningOpenTable Diner Since 2014Dined on 5/24/2014We enjoyed our 10th anniversary dinner here, wonderful service and a nice atmosphere with a number of different areas to take in your meal. The menu changes often enough to always keep Madeline's fresh.Special Features:I would recommend this to a friend.
- Fine dining at its bestTlewis3033Dined on 5/20/2014My husband and I went to Madeleine's for our 30th anniversary. The food was wonderful, nice and quiet, great service, and they have a really nice wine list. A little pricey, but you get what you pay for. Nice place for a special occasion.Special Features:I would recommend this to a friend.
- Gem in the rough!Find2dineDined on 5/15/2014We wanted to find a good restaurant in the area and couldn't be more pleased now that we have tried Madeline's! The atmosphere is very nice and also very appealing(classy without being overdone), the food is wonderful, the tableware is a combined experience of delicate notes from the past mixed with modern style and the service was friendly, knowledgeable and prompt. Excellent meal and experienc and we will go back anytime we are in the area!Special Features:I would recommend this to a friend.
- Excellent and exceptionalCowboyDined on 5/10/2014The service was beyond expectation the moment my wife and I walked in the door. Outstanding service and the food and wine were above expectations. I would highly recommend this restaurant to anyone! My only regret is that we have not eaten there sooner. This will be on our list of places to go, especially when friends and family come to visit.Special Features:
- Last Minute Date nightOpenTable Diner Since 2010Dined on 5/10/2014Menu was very diverse. I could have ordered the entire menu! Food was great but service was very slow. We will definitely dine again and hope for better service.Special Features:
- Great dinner at Madeleinestrav1Dined on 5/6/2014We planned a dinner for four. We had a wonderful dinner with wine. Great night with friends.Special Features:I would recommend this to a friend.
- siebersDined on 4/19/2014Great food and service. One of the best in Evansville!Special Features:I would recommend this to a friend.
- Great time!run4itnickDined on 3/22/2014What a cute place! Every visible surface had thought put into it. The food was delicious, esp the ice cream. The service was so-so. It's fine-dining food, but not fine dining.Special Features:I would recommend this to a friend.
- First timeTizzieDined on 3/8/2014Since this was the first time we had been there overall it was great. We were seated in the front and so we did not see most of the place. Food and service were great! Really need to do something about the noise, it might keep me from returning. It was not energetic it was LOUD!Special Features:
- Quiet, alluring and pleasant.DanutaDined on 3/7/2014This is definitely one of Evansville's gems. A perfect mixture of charm, atmosphere and culinary masterpieces. Just relax and imbibe everything Madeleines has to offer..Special Features:I would recommend this to a friend.
- Madeleine's ReviewJohanDined on 2/5/2014This is the best restaurant in Southern Indiana and as good as you will find anywhere in the world! Great Staff, great food, fresh, willing to work with your diet preferences and a charming little place! Shaun is one heck of a server!Special Features:I would recommend this to a friend.
- Perfect EveningWonderfullyRomanticVIPDined on 1/28/2014What a perfect evening we had at Maddy's very recently! With food at its best and service second to none, Madleine's again provided a truly unique dining experience for Evansville.Special Features:I would recommend this to a friend.


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KayDi's Event's team consists of four fun & professional ladies who all enjoy helping our clients enjoy a smooth & relaxing day! These ladies help to provide many services that we offer such as floral arrangements, set up, transportation, client assistance, and MUCH, MUCH more!
Lakiea, Yohna, Calvett & Courtney

subset: commoncrawl


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Food and Beverage
The Luminous Star™ Bouquet with Swizzle Sampler from Edible Arrangements is the perfect combo of healthy, juicy fruit and irresistible, gourmet, semisweet dark chocolate – the ultimate gift for teachers, co-workers, or neighbors this holiday season.
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text:
Tom Jicha's column in Sun-Sentinel's TV book for Jan. 22 was an unfortunate crossover from his responsibility to answer a reader's question to editorializing _ and not for the first time.
His indictment of vegetarians, or even non-red-meat-eating public, as "wackos" was a poor effort to show his respect for Robert Mitchum as a role model for meat-eaters and hard drinkers. Mitchum should be credited for his acting ability and not for his abuse of his body.


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Avid tennis fan here.
Have been a Fed fan since forever.
Mostly joined htis forum to get info on the USO which i am planning to attend for the first time this year.
Take care.
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text: Science Educational Enhancement Services (SEES) is a diversity program serving historically under-represented minority students in the College of Science. It was established in fall 1987 to increase the retention and the number of under-represented minority students graduating from Cal Poly Pomona with degrees in the sciences and mathematics. The program strives for the retention and graduation of its members by establishing a supportive community among students with these ethnic backgrounds and having technical career goals. SEES services include special faculty advisors in each department of the college, a faculty-alumni-student mentoring program, a science orientation course for freshmen, a study center and computer lab where students can work together, Academic Excellence Workshops, career development workshops and socials throughout the year.


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Care package for soldier
December 19, 2012 more »»
Westfield Academy and Central School September Students of the Month
December 19, 2012 WESTFIELD — On a monthly basis, Westfield Middle School honors one student at each grade level as the Student of the Month. more »»
Westfield Academy and Central School honor, merit rolls for the first quarter 2012-13
December 19, 2012 Merit roll Students earning an average of 85.00 to 89.499 percent are awarded recognition by having their names placed on the merit rol. more »»
Chautauqua Lake Central School honor roll first quarter 2012-13
December 19, 2012 Chautauqua Lake Central School District has announced its honor roll students for the first quarter of the 2011-12 school yea. more »»
Chautauqua Lake Central School Students of the Month — October
December 12, 2012 MAYVILLE — Students of the Month at Chautauqua Lake Central School, honored for October achievements, are Jeremy Lesniowski, Emilie Christie, Jenna Nicole Einink, Jenna Marie Wiemer, Hamzah Khalil... more »»
Sherman Central School Students of the First Quarter 2012-13
December 12, 2012 SHERMAN — The Sherman Central School's senior high Student of the Quarter is Travis Henry, the son of Joan and Terry Henry. more »»
Ripley Central School first quarter honor, merit rolls
December 12, 2012 Grade 12 honor roll: Beatty, Ashley; Chapman, Danielle; Dulmus, Tyler; Horstman, Eric; Mellors, Shanda; Petroff, Ian; Rater, Cody; Tessmer, Sierra. more »»
Eisenhower defeats WACS in HS Bowl
December 12, 2012 JAMESTOWN — Eisenhower Area High School defeated Westfield Academy and Central School 74-57 in a recent WJTN High School Bowl match at Jamestown Community College. more »»
Sherman school teacher donates poster
December 12, 2012 Tammy Hawkins, a Sherman Central School art teacher, recently created a poster for the Ladies Auxiliary to the Veterans of Foreign Wars in the Department of New York to use on a project that will... more »»
Campbell makes JBC President's List
December 12, 2012 JAMESTOWN — Jamestown Business College has announced the President's and Dean's Lists for the fall 2012 term. To qualify for the President's List a student must earn a 3.90 to 4. more »»
Basketball benefit to help CLCS pediatric cancer patient Makuch
December 12, 2012 FORESTVILLE — A benefit basketball game for a local pediatric cancer patient is planned for Saturday, Dec. 8. more »»
Students help clean up Mayville lawns
December 5, 2012 MAYVILLE — Signs reading "Your lawn has been raked" were placed throughout the Village of Mayville on Friday, Oct. more »»
Panama superintendent named administrator of year
December 5, 2012 At its 60th annual conference, the state Association of Educational Office Professionals named Bert Lictus, Clymer resident and Panama Central School superintendent, as its 2012 Administrator of the... more »»
CLCS honor society welcomes new members at ceremony
December 5, 2012 MAYVILLE — The National Honor Society at Chautauqua Lake Central School welcomed new members in a candlelight ceremony recently in the district auditorium. more »»
Goodell recognizes student participation in summer reading challenge
December 5, 2012 State Assemblyman Andy Goodell, R-C-I-Chautauqua County, who sponsored the Summer Reading Challenge in conjunction with the New York State Library's summer reading initiative, recently announced the... more »»
Westfield Parent Connection's Friends of Education Fund receives its first alumni class donation, challenges other classes
November 28, 2012 WESTFIELD — Members of the Westfield Academy and Central School's Parent Connection Friends of Education Fund subcommittee accepted a $500 donation from the WACS class of 1982. more »»
Sherman FFA members compete in Indianapolis
November 28, 2012 SHERMAN — Members of the Sherman Central FFA Chapter in New York made up one of 30 teams participating in the National FFA Food Science and Technology Career Development Event. more »»
Jamestown college to receive $900K biotech grant
November 28, 2012 JAMESTOWN — Jamestown Community College's biotechnology department is about to get a whole lot better. more »»
Sherman Central's 2012-13 first quarter honor, merit roll
November 28, 2012 12th grade honor roll: Shania Allen; Nicholas Ames; Alexandria Anderson; Branda Burick; Allyson Cady; Samantha Delcamp; Kevin Gleason; Brock Griesbaum; Cierra Haskins; Travis Henry; Kyra Levy;... more »»
Clymer Central's 2012-13 first quarter honor, merit roll
November 28, 2012 Honor and merit rolls for the first marking period for the 2012-13 school year for Clymer Central School. The merit roll is students with a 84.5 to 89.49 percent grade point average. more »»
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The birth of the biotechnology industry was accompanied by regulatory uncertainty as well. Neither regulatory agencies nor
sponsors had a clear road map for the monitoring and approval of biopharmaceutical products. Questions surrounding the purity
and safety of recombinant proteins were different from those associated with small molecules. As the new industry grew, regulatory
agencies worked with companies to improve and standardize biopharmaceutical manufacturing, and to develop purity and safety
Throughout the 1990s, the biopharmaceutical industry struggled to meet the needs of a growing pipeline as well as a burgeoning
demand for newly released products on the market. In response to this demand, companies focused on scale, constructing more
manufacturing plants and procuring additional bioreactors and equipment to satisfy the market. It was the age of stainless
steel in the industry. But with unpredictability in product yields, regulatory approval, and commercial demand, essentially
every company struggled with over- or under-capacity.
Like many in the industry, Wyeth has had to deal with adjusting manufacturing capacity to unpredictable requirements in demand.
In 1998, when Wyeth and Immunex launched a soluble TNF receptor–fusion protein (used for the treatment of rheumatoid arthritis)
the product was manufactured under contract by Boehringer Ingelheim. However, US demand alone for the new molecule exceeded
the predicted worldwide demands in the first six months after launch. Neither Wyeth nor Immunex could have anticipated the
tremendous demand for this drug, which could not be met through internal capacity or the capacity available at Boehringer
Ingelheim. Both Wyeth and Immunex (which had merged with Amgen by 2002) responded by renovating older facilities and building
up their own capacity. By 2005, three large facilities were generating ample drug product to meet market demands that continue
to grow dramatically.
At Wyeth, we believe that the productivity and economics of biopharmaceutical manufacturing are about to change dramatically.
While the nature of clinical development and product markets will remain unpredictable, process development and manufacturing
will become more efficient, less costly, and better able to adapt to rapid changes in clinical prospects and market demand.
As a company, we have made it our highest priority to bring about a transformation in manufacturing processes and technology.
Currently, more than one-third of our research and development pipeline consists of biopharmaceuticals (vaccines and protein-based
drugs), while our commercial biotech portfolio brings in annual revenues of approximately $7 billion. This number is expected
to grow in the coming years. Thus, it became a strategic imperative to reject the status quo and find a better, more efficient
way to manufacture our products. We needed to find a better way to manage the direct costs associated with biopharmaceutical
manufacturing, as well as the potential costs related to product development delays (due to process modifications, batch variability,
and non-robust operational systems) and lost sales due to insufficient capacity. To continue with business-as-usual was untenable.
Over the past five years, we have been working on innovations in cell biology, bioprocess engineering, and workflow, resulting
in dramatic increases in yields and efficiencies that will eventually filter through to the rest of the industry. Our objective
is to break through the paradigm that biotechnology drugs are expensive to produce. Here, the biopharmaceutical industry has
an opportunity that is not available to manufacturers of small-molecule therapeutics: improving production efficiency through
In the past 10 years, we have been successful in increasing the volumetric productivity of our clinical monoclonal antibody
processes more than 10-fold and as much as 30-fold for next-stage processes, where new technology has been applied.1,2,3 We can achieve volumetric productivity levels of 10 grams per liter in fed-batch cultures. These results have been achieved
through cell engineering efforts, increasing the amount of protein produced per cell, as well as increasing the viable cell
density of the production culture through proprietary fermentation technology. A single 5,000-L bioreactor can now produce
the same amount of product (about one metric ton per year) equal to that produced by 100,000 L of fermentation capacity using
previous technology. In addition, advances in purification technology have led to streamlined processes that use limited chromatography
steps, resulting in high process yields (80%) and purity, while reducing water and buffer usage, suite labor, and ultimately,
lowering the cost of goods.
The goal is to replace stainless steel with biology, to put more resources and efforts into improving the efficiency of biological
expression rather than building more reactors and more manufacturing plants. A 10- to 30-fold improvement in manufacturing
efficiency has the potential to transform the business model of the entire biopharmaceutical industry, influencing decisions
about whether or not to build facilities and about how to allocate resources, plan product portfolios, and respond to shifting
market landscapes.


text:
Java/J2EE Developer (closed)
Orlando, FL
$70,000-90,000 compensation
Report this Job as Spam
Job Description
Java/J2EE Developer needed for a permanent position in the Orlando, FL area.
- As a member of the development team you will design and develop software components for enterprise web applications
- Write clear, detailed application specifications
- Work on compelx problems where analysis of situations or data requires evaluation of various factors
- Trouble-shoot difficult and complex software issues
- Write Test scripts for new and existing software functionality
- Create and track software defects
- BS/BE Computer Scinec or related business field along with 3-5 years experience.
- worked in progressively responsible technical roles
- substantial subject matter knowledge
Required Skills:
- Must have struts 2.0 and spring experience
- Heavy Java both front end and backend
- XML, HTML, CSS, Javascript, and AJAX


text:
Isles Files
Your source for behind-the-scenes New York Islanders hockey news and information.
BloggersArthur Staple
ArchivesMore »
One day left = two new Islanders videos
Embedded above is the Islanders video we shot Friday at Nassau Coliseum on the eve of the start of the lockout-shortened NHL season.
It includes interviews with John Tavares, Matt Moulson and Kyle Okposo.
Embedded below is highlights of our sitdown with Arthur Staple to discuss the start of the season for the Islanders.
Those reading this on Newsday's apps can watch the video here on our Facebook page https://www.facebook.com/video/video.php?v=10100843057956895
Tags: video , john tavares , matt moulson , kyle okposo


text:
(Mineola, NY) Nassau
County Clerk Maureen O'Connell joined Boy Scout Troop #5 of Massapequa
at their Eagle Scout Court of Honor Ceremony for Michael Richard
Imbrogno of Massapequa. County Clerk O'Connell, along
with other area officials, the leaders and families of Troop #5 honored
this outstanding young man who has demonstrated great commitment
to community service. Clerk O'Connell presented Michael
with a County Citation in recognition of his achievements. Michael's
dedication and many accomplishments earned him the rank of Eagle
Scout which is the highest award in the Boy Scouts of America. Congratulations
to Michael, and the entire Troop #5 family on this special occasion
and for all his great work on behalf of the community.


text:
view bio »
LSU head coach Johnny Jones calls a play during the second half of an NCAA college basketball game against Kentucky in Lexington, Ky.Photo by Associated Press /Chattanooga Times Free Press.
The Southeastern Conference began this week with half of its men's basketball teams owning 7-7 league records.
The sizable logjam has evoked mixed reactions from the league coaches, with LSU's Johnny Jones leading the optimistic viewpoint.
"I think it just speaks to how great our league is and how competitive it is from top to bottom," Jones said. "You look at what [nationally top-ranked] Florida has been able to do, but they've been in some tough, challenging games, and so has [second-place] Kentucky."
LSU, Arkansas, Texas A&M, Ole Miss, Missouri, Tennessee and Vanderbilt all entered this week with 7-7 SEC records, and Vandy was the first to fall from that list -- with Tuesday night's loss to the No. 1 Gators. Commodores coach Kevin Stallings has never seen a bigger cluster of teams in his 15 years within the league, and he doesn't view it as a good thing.
Especially not in the eyes of the NCAA tournament selection committee.
"I think the fact that we've all kind of beaten up on each other a little bit has hurt us in some regards nationally," Stallings said. "I think it's hurt the perception of our league a little bit nationally, but I'm very optimistic that the teams that do get into the tournament from our league will do very well."
The two most prominent NCAA tournament projections tend to support Stallings and his concern. ESPN's Joe Lunardi has Florida, Kentucky, Missouri and Tennessee in his mock bracket, with Cuonzo Martin's Volunteers being relegated to a play-in game, while CBS's Jerry Palm has just Florida, Kentucky and Missouri making the 68-team field.
Should the SEC send three teams, it would mark the third time in six years the league had such a small delegation. The SEC had at least five teams in the tournaments from 1997 through 2008.
"The SEC has nine teams in the top 100 of the RPI," Martin said. "You get criticized throughout the course of a season, but when you look at the numbers, the SEC is one of the top leagues in the country."
According to the RPI used by CBS, the SEC is currently the seventh-best league behind the Big 12, Big Ten, Pac-12, Big East, Atlantic Coast and Atlantic-10.
"Obviously it's going to play itself out with records and RPIs and whatever the committee looks for in terms of making those selections," Florida coach Billy Donovan said, "but look at the way Georgia has played. Ole Miss is very, very good. Tennessee is outstanding. LSU is talented. Arkansas is playing well. Then there's Missouri.
"We have an opportunity to get a good number of teams in, but a lot of it is going to depend on how things shake out the final two weeks of the regular season and in the conference tournament."
Contact David Paschall at firstname.lastname@example.com or 423-757-6524.
David Paschall is a sports writer for the Times Free Press. He started at the Chattanooga Free Press in 1990 and was part of the Times Free Press when the paper started in 1999. David covers University of Georgia football, as well as SEC football recruiting, SEC basketball, Chattanooga Lookouts baseball and other sports stories. He is a Chattanooga native and graduate of the Baylor School and Auburn University. David has received numerous honors for ...


text:
DIC: Domain Name Registries to Promote DNSSEC
The DNSSEC Industry Coalition (DIC) was founded in the U.S. with the goal to drive further development and acceptance of the DNSSEC security protocol. The consortium includes a half dozen top Domain Name Registries and software developers that are currently laying out an action plan.
Despite regular crises in the Domain Name System (DNS) and weaknesses of relevant software, such as shown by recent DNS attacks, the DNSSEC protocol has had a slow adoption rate. According to a recent survey by the Measurement Factory, among the estimated 11.9 million existing nameservers only a minute proportion use DNSSEC. The coalition intends to address this issue.
Certain registries have found common ground. Among them are the ones for the top domains .org, .info, .edu, .com, .net, and for country specific ones like .se, .uk, .tv and .cc. Add to these software providers such as ISC and BIND, which is by far the greatest provider of nameserver software.
In their announcement, the members of the DNSSEC Industry Coalition promise to develop common tools and applications to make DNSSEC easier to adopt. They also intend to set an example. The effect this will have on users outside the big ISPs is still to be seen. Technical solutions for DNSSEC have existed for a long time, but top name registries have been reluctant to adopt them up to now.
Issue 170/2015
Buy this issue as a PDF
TOR Network Isn't So Anonymous
A new study says it is possible to unmask 81% of TOR users.
.NET Goes Open Source
Redmond joins the revolution by turning the .NET Core Runtime into a GitHub project.
Drupal Advisory Unleashes a Torrent of Attacks
Users only had 7 hours to update before the intrusions started.
HTML5 Gets Promoted to a Standard
It's official: The new web arrives
Linus Addresses Criticism for Harsh Language
Kernel king admits his tone has alienated volunteers, but says the demands of the process require directness.
New SSL Attack Lets a Malicious Listener Steal Session Cookies
New flaw in an old encryption scheme leaves the experts scrambling to disable SSL 3
Leading Open Source Coder Rants about Rants
Lennart Poettering wants to change the way Linux developers talk to each other.
HP Splits into Two Companies
Enterprise giant frees itself from ink and home PCs (and visa versa).
Mozilla Labs Shuts Down
Mozilla's product think tank sinks silently into history.
Internet Giants Launch Collaboration to Improve Open Source
TODO group will focus on open source tools in large-scale environments.


text:
Understanding the mechanisms of drug resistance in enhancing rapid molecular detection of drug resistance in Mycobacterium tuberculosis
SUNScholar Research Repository
Faculty of Medicine and Health Sciences
Department of Biomedical Sciences
Molecular Biology and Human Genetics
Doctoral Degrees (Molecular Biology and Human Genetics)
View Item
Understanding the mechanisms of drug resistance in enhancing rapid molecular detection of drug resistance in Mycobacterium tuberculosis
Johnson, Rabia
Date Issued:
One of the aims of direct observed therapy strategy implemented by the World Health Organization was to prevent the development of drug resistant tuberculosis. However, in recent years a dramatic increase and spread in multidrug resistant tuberculosis has been observed. In this study, a molecular epidemiological approach was used to understand and rapidly detect drug resistance in high incidence tuberculosis communities of the Western Cape, South Africa. Previous studies showed that, drug resistant tuberculosis occurs as a result of spontaneous mutations in particular genes. Using molecular techniques, we developed an algorithm to rapidly detect isoniazid, rifampicin and ethambutol drug resistance in tuberculosis patients from a short term mini culture. Rapid detection of drug resistance is important to prevent future transmission events. In addition, accurate ethambutol resistance testing is of particular importance, since treatment of patients infected with multidrug resistant strains with second line anti-tuberculosis drugs depend on the ethambutol test results. In a comprehensive study, we found that the algorithm performs well when compared to the traditional culture method currently used by the routine laboratories. However, the results showed that more then 90 % of ethambutol resistance is missed by the routine laboratories. This has important implications for the tuberculosis control program, since patients infected with the drug resistant strain may be on inappropriate treatment. In this study, we found that certain strains have a selective advantage to become drug resistant and transmit and this implies that they are more virulent and fit than other strains. This observation has also been made for strains within the same genotype family. The more transmissible drug resistant strains cause large drug resistant outbreaks. This study highlights the complexity of the drug resistant epidemic, and confirms that it is a major problem in local communities. Application of molecular methods has provided us with tools to study how resistance might develop. We have demonstrated how we made use of a newly developed method to detect a multidrug resistant outbreak in the study community. The applications of transcriptomics identified several genes that might play a role in isoniazid resistance. Using this data a model was proposed whereby isoniazid resistant strains can compensate for the toxic effect of the drug. Application of comparative genomics by whole genome sequencing will be used to assist us in the further understanding of the mechanisms of drug resistance. This study also conclude that we should continue in our attempts to develop faster diagnostics for both first and second line drugs and that we must not loose site that all of this research must in the end benefit the patients.
Thesis (PhD (Biomedical Sciences. Molecular Biology and Human Genetics))--University of Stellenbosch, 2007.
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La France n'est pas seulement riche de son passé et de ses musées, elle regorge de talents qui rayonnent au-delà de nos frontières (Medtech, Nanobiotix, ....)
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From www
Ipsos FranceNeurosciences : Ipsos s'associe à NEUROHM, leader mondial des ...
A kit of 3D-printed anatomical body parts could revolutionize medical education and training, according to its developers at Monash University.
Professor Paul McMenamin, Director of the University's Centre for Human Anatomy Education, said the simple and cost-effective anatomical kit would dramatically improve trainee doctors' and other health professionals' knowledge and could even contribute to the development of new surgical treatments.
"Many medical schools report either a shortage of cadavers, or find their handling and storage too expensive as a result of strict regulations governing where cadavers can be dissected," he said.
"Without the ability to look inside the body and see the muscles, tendons, ligaments, and blood vessels, it's incredibly hard for students to understand human anatomy. We believe our version, which looks just like the real thing, will make a huge difference."
The 3D Printed Anatomy Series kit, to go on sale later this year, could have particular impact in developing countries where cadavers aren't readily available, or are prohibited for cultural or religious reasons.
After scanning real anatomical specimens with either a CT or surface laser scanner, the body parts are 3D printed either in a plaster-like powder or in plastic, resulting in high resolution, accurate color reproductions.
Further details have been published online in the journal Anatomical Sciences Education.
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ChemaCepeda's curator insight, July 23, 4:22 AM
La impresión 3D también va a mejorar la manera en que nos formamos los profesionales sanitarios
100 mil millones de imágenes circulan en Facebook , el 77% del total del contenido compartido en Facebook. La imagen es el contenido preferido.
Via jose antonio gabelas
Education Research - A five minute video summary of four articles related to experiences, and strategies for creating professional learning networks in an organization.
From wesharescience
A five minute video summary of four articles related to experiences, and strategies for creating professional learning networks in an organization. 5MSF
Via Dr. Susan Bainbridge, María del Carmen Quiñones Martínez
From coreight
Les français sont de plus en plus intéressés par la technologie, à différents degrés. Illustration en image
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The first problem is that we start with a Persona, which is a very bad idea, and then plop in an action which we think should be taken in order to achieve the expected outcome.
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This is a great replacement for user stories. Be sure to also follow the link at the end that takes you to his other article "5 tips for writing better job stories"
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text: Rumors that an IKEA furniture store could open in St. Louis kept news outlets and Facebook campaigns busy for years before Swedish retailers made the deal official last week. Every few months, it seemed, a fresh whisper would reignite the blogs and comments in business gossip. But now that IKEA see ... More >>


text:
Book your room at Buffalo Tavern Bed & Breakfast
West Jefferson bed & breakfast with a complimentary breakfast
Situated in West Jefferson, this bed & breakfast is in the same area as Museum of Ashe County History and Ash County Park. Regional attractions also include Blue Ridge Music Center.
Property Features
Amenities at Buffalo Tavern Bed & Breakfast include barbecue grills.
Room Amenities
Televisions come with satellite channels. Guestrooms also feature bathrobes and private bathrooms.Information missing or incorrect? Tell us!
At your hotel
At your hotel
A complimentary breakfast is offered.
Buffalo Tavern Bed & Breakfast has designated areas for smoking.
- Year Built 1872
- Barbecue grill(s)
- Free breakfast
- Front desk (limited hours)
- Designated smoking areas
In your room
- Private bathroom
- Bathrobes
- Satellite TV service
Eat and drink
Guests are offered complimentary continental and full breakfasts.
The fine print for Buffalo Tavern Bed & Breakfast
When you arrive
Check-in time ends at 7 PM
Check-in time starts at 4 PM
When you leave
Check-out time is 11 AM
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.


text:
MINEOLA, NY – Nassau County District Attorney Kathleen Rice announced today that a jury has convicted Kevin Cohen of grand larceny, fraud, and forgery charges for stealing more than $300,000 from prospective adoptive parents by promising them babies that did not exist. Cohen, an attorney, went so far as to present hopeful couples with fake sonograms and fictitious records on forged stationary from hospitals and doctors to carry out his scam.
The jury deliberated for about a day before convicting Cohen, 42, of Roslyn, of Grand Larceny in the Second Degree, 11 counts of Grand Larceny in the Third Degree, three counts of Criminal Possession of Forgery Devices, Attempted Grand Larceny in the Third Degree, Scheme to Defraud in the First Degree, 10 counts of Forgery in the Third Degree, eight counts of Criminal Possession of a Forged Instrument in the Third Degree, and two counts of Criminal Impersonation in the Second Degree. He faces up to 92 years in prison at his December 7 sentence date.
During the three-week trial, the jury heard testimony from 13 prospective parents who had been scammed by Cohen who previously had headed an agency called the Adoption Annex. The Adoption Annex had been set up to provide information to prospective adoptive parents, but was defunct by 2008.
In most cases Cohen's adoption scam scenario was similar. He would tell the couple that he had a young, unmarried mother who lived in either in Nebraska, Pennsylvania, or Arizona who wished to give up her baby for adoption.
Rice said that from October 2007 until the time of his arrest in September 2009, Cohen held himself out as a legal expert in adoption proceedings. He was able to obtain large sums of money from couples to arrange adoptions. Couples, including those from Georgia, Texas, and Ohio, gave Cohen the money believing it would be held in escrow to pay for the medical costs and other expenses of birth mothers who wished to have their children adopted.
One couple paid Cohen $60,000 after he claimed that he had located two prospective out-of-state birth mothers who were looking to give up their babies for adoption. In reality, these birth mothers did not exist and were fabricated by Cohen. Cohen went as far as to create forged medical records and information for the fake birth mothers which he gave to couples looking to adopt.
One couple said that their two other recently-adopted children had turned over their life savings of $500 to help their parents with the cost of adopting another baby. Another woman waited for days in a Pennsylvania motel room down the road from a hospital where Cohen said the birthmother was going to deliver. The hopeful adoptive mother returned home with no baby after Cohen told her that the mother had changed her mind. Often Cohen would comfort the families after a "failed adoption." In order to assure that the family would not request their money back, Cohen would tell the family about another adoption situation, promising them that this time they would be parents.
"There are no words to describe the pain and torment this defendant inflicted on kind and generous couples looking to provide a child with a loving home," Rice said. "Now, with Kevin Cohen headed to prison, he will never again have the chance to destroy another family's dream of adopting a child."
Deputy Chief Karen Bennett of the Street Narcotics & Gang Bureau and Assistant District Attorney Andrew Garbarino of the Public Corruption Bureau are handling the case for the DA's Office. Cohen is representing himself.


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THIS IS A MANUFACTURER DIRECT ITEM. THIS ITEM SHIPS ON OR BEFORE Tuesday, December 9 th
Commemorate the National League in the 84th annual MLB All-Star Game with this game-used collectible. Each individually-numbered collectible comes with National League team logos and player images. It comes with an actual piece of game-used base and ball from the 2013 MLB All-Star Game obtained under the auspices of the MLB Authentication Program and can be verified by its numbered hologram at MLB.com. It is officially licensed by MLB and framed in black wood. This collage is one of a limited edition of 500, measures 15" x 17" x 1" and comes ready to hang in your home or office.
- Collectible framed collage
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