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Media outlets have been reporting for months (or longer, in the case of Westword) about how law enforcement officers in Kansas, Nebraska, Wyoming, Oklahoma and other Colorado border states are stopping cars with green-and-white license plates more often since the legalization of marijuana here. (One ... More >>
April Fool's Day pranks are a sacred tradition for Denver Cruiser Ride. Last year, for example, the Cruisers released a collection of bogus themes for the weekly Wednesday rides (including "Skid Marks & Seamen Stains") before sharing the genuine items. And this year? The Cruisers unveiled the real ... More >>
Traditionally, April Fool's Day is a time to play tricks on others. But this time around, we played one on ourselves. As we were assembling a post featuring March's most memorable mug shots (it's coming later this week), we discovered we'd neglected to publish one for February. Hard to say why, sinc ... More >>
Within the first few weeks of our relationship, my boyfriend and I had told each other everything. I think that in the modern cultural lore of love, one of the ways a true "connection" with someone is established is if you have the comfort and desire to air all of your dirty laundry to them. I did t ... More >>
Craft breweries and related companies love April Fool's Day and each year, they skewer their fans, their competitors, big breweries and themselves with jokes. But these breweries are also innovators, and a couple of years ago, one of these jokes actually became reality when Wynkoop Brewing produced ... More >>
Colorado Craft Beer Week kicked off last Friday at the Governor's Mansion, where our brewer-in-chief, John Hickenlooper, toasted the brewing industry in the state and unveiled three draft handles that will now serve the historic home. But the events at breweries, restaurants and bars around the stat ... More >>
In 2011, Boulderites voted to take care of their own power needs, giving Xcel Energy the boot. Now, New Era Colorado, a pro-municipal-energy outfit, says Question 310, an Xcel-linked measure on the November ballot, may undo the entire project. To fight back, New Era created a video casting the battl ... More >>
Update: Yesterday, Denver police announced, with a good deal of hoopla, that an arrest had been made in the March 31 vandalism of the Big Blue Bear at the Colorado Convention Center, during which the tourism symbol was splashed with green paint. Mere hours later, however, the Denver District Attorn ... More >>
Denver Cruiser Ride organizer Brad Evans thinks big -- and not just when it comes to pranks like releasing an April Fools Day 2013 themes list featuring selections like "Skid Marks & Semen Stains." When Evans previewed the upcoming Denver Cruiser Ride season, which kicks off May 15, he told us abou ... More >>
The Denver Cruisers know how to stir things up. Rather than simply announce the 2013 themes for the mega-popular Wednesday rides, Brad Evans and company released an April Fools' Day version first -- one that turned heads via concepts like "Skid Marks & Seamen Stains." Behind the edgy irreverence, o ... More >>
In some ways, it's appropriate that Richard Howard Craft, a disgraced former Greeley pastor, was sentenced to federal prison on April Fools' Day. Then again, "fool" is too mild a term for Craft given what he's admitted to doing. And frankly, "schmuck" doesn't really cut it, either, although it'll d ... More >>
There's been the usual squawking over the Best of Denver -- complaints about the editorial picks in various categories, and much louder complaints over many of the Readers' choices. And, of course, there have been the standard queries about why the editorial picks are given so much more prominence t ... More >>
If it was intended as an early April Fools' Day joke, it wasn't a very funny one. On Saturday night, vandals splashed green paint on the Big Blue Bear, the symbolic mascot of the Colorado Convention Center, and of Denver tourism in general -- if you don't count DIA's demon Mustang, that is. See pho ... More >>
Do you love April Fools' Day? Or do you think it's the most annoying holiday ever -- an excuse for amateur comedians to play pranks proving once and for all they're not very funny? We've gathered together a collection of April Fools' Day memes intended to appeal to both groups. Check them out belo ... More >>
Members of the Air Force spend their days defending the rest of us from evil-doers, and we're grateful. But they apparently have enough free time to engage in Facebook-related pranks. Today's bizarre examples: Members of a sorta-unknown squadron have stolen a sister outfit's super-irritating air ho ... More >>
It took balls for the Wynkoop Brewing Company to turn an April Fool's Day joke about a brew made with bull testicles into reality in October, during the Great American Beer Festival. But the brewery really had to sack up after that, as it negotiated with the feds about what it could and couldn't pu ... More >>
Update 12/4/12: Well, that was short-lived. Turns out Pot 107 was an aberration after all, and not a actual format. If you tuned in to the 107.1 frequency this morning hoping to hear Denver's Dope Hits, you no doubt noticed that, rather than hearing an endless loop of ganja goodness, you were greete ... More >>
Every November, I cook a turkey. Not on Thanksgiving, but a couple of weeks early. This way, I can get a taste of Turkey-Day excitement early and not have to stuff myself on the actual day, ending up in a tryptophan-induced coma. The same plan also helps you survive Great American Beer Festival week ... More >>
Malt, water, hops, yeast...and bull testicles. That's the recipe for the ballsiest beer that Denver's Wynkoop Brewing Company has made in its 24-year history, and one that it will start serving on October 8 during Great American Beer Festival week. Rocky Mountain Oyster Stout, which started off as ... More >>
April Fool's Day jokes often seem funnier to those pulling them than they do to their targets. That was undoubtedly the case for bogus letters claiming that Xcel Energy would be cutting off anyone who voted to end Boulder's relationship with the power supplier.
Wynkoop Brewing pulled off an outstanding April Fool's Day joke last weekend, producing this ballsy video about a fake beer: Rocky Mountain Oyster Stout. "These testicles; they're very fresh." In fact, it could be one of the funniest, best-produced joke videos to come out of our state's 140-plus cra ... More >>
Denver blog posts are over April Fools Day. At Mile High Report, Nick Cast notes that with Tim Tebow gone and Peyton Manning on board, no one will be shocked if the Broncos win. DenverUrbanism's Ken Schroeppel looks at Denver single-family homes circa the 1920s. Denver Frank shares a video he dub ... More >>
Great news for dance music fans, just in time for Caffeine this weekend: Hot 107.1 just flipped formats. The former Top 40 station, owned by Max Media, will now be catering the electronic dance community. Partnering with Denver-based Global Dance Music, the station will now be spinning the biggest b ... More >>
Craft brewers sold $8.7 billion worth of beer in 2011, up more than 9 percent over the previous year, according to the Boulder-based Brewers Association. That's a lot of suds. The total amount of beer they made rose 13 percent, or roughly 1.3 million barrels, to nearly 11.5 million barrels. The num ... More >>
When our esteemed art director (who we will decline to explicitly name for reasons that will become clear... now) designed the photo that accompanied Embattled Painting of the Virgin Mary fellating Christ appears to weep blood (at right), our fake April Fool's day joke article, he mentioned h ... More >>
Tom MurphyThe Inactivists The Inactivists With Little Fyodor & Babushka Band and The Skivie sWalnut Room | April 1, 2011 At least this show didn't turn out to be a April Fool's Day joke of some kind. But that's a possibility given that The Inactivists are jokers with a wickedly mischievous ... More >>
Welcome to In the Weeds. Kyle will be right with you -- most likely to complain about something. Usually he is pleasant, but this is his place to blow off some steam. Don't take it personally; he just needs to vent because he's been doing this for about thirteen years. Enjoy your meal. Serve ... More >>
It's the cheese to your prankster macaroni.There are things in this world that really were made to be together. April Fool's Day, for instance, is really nothing more than an excuse to be roguish and weird -- the exact qualities that are the basis for all that is steampunk. Peanut butter, m ... More >>
J.R. Smith.Nothing to fear from these three Denver blog posts -- since it's not April Fools' Day yet. Roundball Mining Company's Kalen talks about how a potential trap game against the Sacramento King became another testament to teamwork by everyone on the Nuggets -- even J.R. Smith! Colora ... More >>
John Hickenlooper.Denver blog posts are multiplying like rabbits... with calculators. Colorado Pols' NCAA-style bracket to determine the state's political powerhouse for the year is down to its final two contestants -- John Hickenlooper and Ken Salazar. Vote early and often. Square State's ... More >>
Friday is opening day at Coors Field, and that means the return of Colorado's most unusual brewery, the Blue Moon Brewing Company @ the Sandlot. Open only during Colorado Rockies home games and only during baseball season, the Sandlot is celebrating its sixteenth year of serving baseball-the ... More >>
Proud to be an American.This week gets off to a strong start with Something on a Stick Day, a holiday dedicated to that great American pursuit of putting food on sticks before eating it -- well, actually, the Middle East probably got the jump on this one with their kebabs and whatnot, but did ... More >>
Salt River FieldsMajor League pitchers and catchers report to spring training today -- Valentine's Day. Which is appropriate considering how little most of the guys will see their loved ones over the next seven or eight months. But the brand spanking new Spring Training facility for the Colo ... More >>
Sing, Forbes, sing! Nugget Kenyon Martin's birthday was surely better than his April Fool's Day, when teammate J.R. Smith's driver filled K-Mart's SUV with buttered popcorn. The power forward's December 30 birthday appears to have been a happier affair, though it too involved some Nuggets haz ... More >>
Tom Tancredo.It was just a week ago that former congressman and presidential/gubernatorial candidate Tom Tancredo and "Ask a Mexican" columnist Gustavo Arellano debated immigration in front of a packed house in Denver. And the fun's not over yet.
My First Bacon: you've got a friend in meat"What child on this planet wouldn't want to befriend a piece of mostly meat held together with fat and love?" asks ThinkGeek, the affable producer of all kinds of geeky wares. Mario Batali jokes notwithstanding, we have the same question. Who WOULDN ... More >>
Apparently, it's not the triple cream Brie, the foie gras or chicken liver pâté, or the supersize burger, milkshake and xx-large boat of fries that's contributing to our nation's obesity. Nope. According to new research, the muffin that droops over your waistline is caused by the "fat bug, ... More >>
The offending white meatPerhaps you've heard by now about the legal scuffle that's pitting The New White Meat against The Other White Meat. Here's a primer, if not: About a week ago, the Pork Board sent a cease and desist letter, via Denver's Faegre-Benson legal team, to ThinkGeek. The lette ... More >>
Chopstick to it. Today in Cafe Society: • IACP Conference Report: Drunk and in possession of press credentials. • IACP Conference Report: Food writers are good in bed. • Veggie Girl: US Thai Cafe. • Mini Bar set to open in April. • Green Energy: Jason Sheehan is right! • Opening today: ... More >>
On Wednesday, April 1, the Wynkoop Brewing Co. (1634 18th Street), will host an April Fool's Day beer dinner inspired by Dr. Seuss; the first pour is at 6:30 p.m. Tickets are $35, for reservations, call 303-297-9999. Or go hog wild at Zolo Southwestern Grill at 2525 Arapahoe in Boulder, where chef ... More >>
Earlier today, the liberal ProgressNow Colorado organization sent out its regular e-mail news digest under the signature of Dick Wadhams, head of the Colorado Republican Party, complete with a goofy pic of Dick at the top. Happy April Fool's Day! But something not as funny from ProgressNow's standpo ... More >>
I have to extend an apologetic hand to both my fellow Westworder Joel Warner and, by extension, the Highland Mommies -- the web message board group in North Denver; See, at Monday's editorial meeting, Mr. Warner brought up a rumor he'd heard that Chipotle was changing its menu. There weren't many de ... More >>
Of all the things to be celebrated cross-culturally, to have the potential to bring people of the world closer together, it would have to be April Fool's Day. Seriously, any other holiday would be better, don't you think? Instead of turning our friends into dupes, maybe we could all do something m ... More >>
In 1988, Westword published its fifth Best of Denver issue, a celebration of the city that saluted everything from the Best Band (the Subdudes, just going national) to the Best Hungry Young Band (Big Head Todd and the Monsters, long before they started singing Hillary Clinton's song) to the Best H ... More >>


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Wednesday, October 10, 2012
Being So Glad
One of the reasons I was glad that Ed and not David Miliband won the Labour leadership in the aftermath of the 2010 General Election was that I thought that having been Foreign Secretary in the dog days of the last Labour administration would mean that the older Miliband would be unable to rid himself or his party of the stench of their complicity in so many of the horrors of the War on Terror. I was also glad because having been Foreign Secretary in the dog days of the last Labour administration meant being the kind of Blairite shit who, at best, thought that complicity was a price worth paying for, well, what exactly was never quite clear, but it wasn't only an ideological complaint: this was tactics; I could see any criticism of anything particularly vile the Coalition did being countered with reminders of the Labour leader's involvement in extraordinary rendition, of the party being unable to extricate itself from its entanglement in the quasi-imperial projects of the lunatic fringe of the Republican party and so unable to hold the government to task. So this, reminding us that Miliband assured MPs that rendition was not taking place via Diego Garcia when he was Foreign Secretary, is in a certain kind of sense reassuring. On the other hand, it reminds me that my Department is kindly offering a little prestige in their retirement to someone whose career may well end up being defined by their complicity in and lies to Parliament about torture.
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subset: commoncrawl


text:
|Total (w/tax)
|Total (w/tax)
Book Description:
"A fabulously entertaining new quartet—with links to her popular Cynster series….Laurens adds a dash of exotic spice to her always reliable mix of sexy romance and risky intrigue."—Booklist The fourth book in New York Times and USA Today bestselling author Stephanie Laurens's sensational Black Cobra Quartet, The Reckless Bride is a brilliant mix of intrigue, danger, and historical romance from one of the very best in the business. A breathtaking adventure set in England's Regency Era, The Reckless Bride continues the acclaimed romance novelist's extraordinary chronicle of love and duty, as brave ex-officers of the Crown band together to destroy the traitorous fiend known as The Black Cobra.
Tags: Literature-Fiction, Genre-Fiction, Historical,


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Democrats have asked state election officials to keep six Republicans running as Democrats off this spring's recall ballots.
Democrats have forced Republican Gov. Scott Walker, Republican Lt. Gov. Rebecca Kleefisch and four GOP state senators into recalls to punish them for passing a law that stripped public workers of their union rights.
Six Republicans are running as Democrats to ensure a Democratic primary in each race. The Democrats' attorney, Jeremy Levinson, filed a complaint with the Government Accountability Board Thursday asking the board to disqualify them, saying they falsely represented themselves as Democrats when they were collecting nomination signatures.
GAB spokesman Reid Magney says the board will consider the complaint at a meeting next week.
State Republican Party spokesman Ben Sparks didn't immediately return a message.
(Copyright 2012 by The Associated Press. All Rights Reserved.)
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text:
- ServSafe Registration Information
- ServSafe Allergens Program
- ServSafe Food Handler Program
- ServSafe Alcohol Training
The ServSafe Food Safety® Programs deliver much more than training. They combine critical information, exclusive tools, and real world resources to transform knowledge into action. In short, ServSafe puts the highest standard to work for you every day.
ServSafe Food Certification Managers Course
The ServSafe Food Protection Manager Certification is nationally recognized and accredited. To date, more than 4 million ServSafe Food Protection Manager Certifications have been awarded. Learn the latest on sanitary food handling, food preparation, food-borne illness and the way to prevent it!
Why be certified?
- The ServSafe Food Protection Manager Certification is accredited by the American National Standards Institute (ANSI)-Conference for Food Protection (CFP) and is valid, reliable and legally defensible.
- Train your staff in the highest standard of food safety training and certification.
- ServSafe is a better way to learn, with training options to fit your needs. It's more engaging, for greater comprehension and better application.
- Better customer satisfaction. Food safety impacts your customers, your employees and your business. With so much on the line, the right preparation means everything.
About the course...
NIFI and the Educational Foundation of the National Restaurant Association, which is recognized nationwide, designed the Serving Safe Food Certification Course.
How it works...
Upon registration for the course you will be mailed class details and a course book. Registration must be received at least 10 days prior to the course date.
The test for this course is given at the conclusion of the class, on the same day. You must receive a 75% or above to be issued a certificate. Those who pass the examination receive a certificate from the MRA and the National Restaurant Association Educational Foundation, where certification is held in a transcript and is good for five years. Certificates will be mailed within 2-3 weeks of the class date.
The cost for MRA Members is $100.00, the cost for Non-Members is $160.00.
If you are interested in joining the MRA please click here for more information.
Registering to attend a ServSafe Certification Course is easy!
For ONLINE registration and a full list of MRA sponsored classes, click here
For mail, email, and fax registration, simply download the appropriate ServSafe session brochure below, complete, and return with payment.
ServSafe - Kansas City (Classes held at US Foods in Lenexa, KS)
ServSafe - St. Louis (Classes held at PFS Middendorf)
ServSafe - St. Louis (Classes held at US Foods)
ServSafe - Jefferson City (In partnership with Confidential Restaurant Solutions)
ServSafe - Southwest Missouri (In partnership with Tom Food Safe LLC)
For questions, please contact:
Diane Archambault, St. Louis office, firstname.lastname@example.com
Call us toll free at 877-413-7029 for further class information.
ServSafe Allergens Program
The NEW ServSafe Allergens online, interactive course drives home critical information your employees and managers need in order to accommodate guests with food allergies. The ServSafe Allergens online course covers such topics as identifying allergens, communication with the guest, preventing cross-contact, food labels and more.
The number of Americans affected by food allergies is trending higher every year. Dining out is a serious concern for them as well as their family and friends. Those who deal with this life-threatening condition are often unsure which restaurants can safely accomodate them-if at all. That's why making your restaurant staff allergy aware can help increase your revenue opportunities.
To capitalize on this opportunity, you and your employees need to have the basic information required to ensure everyone takes the steps necessary to keep your customers safe. And the ServSafe Allergens Online Course is your best, most trusted source for qualified online training. Get started today!
ServSafe Food Handler Program
The ServSafe Food Handler training and assessment program is a complete solution that delivers consistent food safety training to employees.
ServSafe Food Handler covers five key areas:
- Basic Food Safety
- Personal Hygiene
- Cross-contamination & Allergens
- Time & Temperature
- Cleaning & Sanitation
The ServSafe Food Handler Program uses best-in-class training to get your employees ready for the workplace.
Access training information here or call toll free 877-413-7029 if you need additional information.
ServSafe Alcohol Training
The Missouri Restaurant Association presents the ServSafe Alcohol Training program from the National Restaurant Association. This program is designed to help our members protect themselves in the wake of the Supreme Court decision that threw out Missouri's dram shop civil liability protection for restaurateurs and bar operators.
The ServSafe Alcohol training program is designed as a series of the train-the trainer workshops and basic server/bartender training for owners, managers, food and beverage directors, service coordinators, trainers, bartenders, and servers. This comprehensive training program:
- Teaches proper techniques of responsible beverage alcohol service
- Alerts participants to alcohol's effects on the body
- Informs operators and managers on how local and state laws affect them
- Provides guidance in identifying and handling problem situations through videos and role playing exercises
- Presents effective internal communications techniques
- Helps reduce the risk of third-party liability lawsuits
- Positions restaurant businesses for reduced premiums on their liquor liability insurance coverage
- Promotes repeat business by encouraging a relaxed and friendly atmosphere
- Unlike other beverage service training programs, ServSafe Alcohol provides a complete program that allows restaurateurs the flexibility and savings of training their own servers on site rather than sending them to expensive and time-consuming classes.
- By allowing restaurateurs to schedule and conduct in-house training of wait staff, ServSafe Alcohol provides the knowledge, techniques and information restaurateurs need to protect their businesses in a sensible, cost-effective manner.
ServSafe Alcohol training is available to MRA members for $35 per person. This includes training, training manual and test. Non-members may also attend the training, although seating is limited and first preference will be given to MRA members. The cost for Non-Members is $50.
If you are interested in joining the MRA please click here for more information.
Call the MRA offices toll free at 877-413-7029 if you need additional information.
Additional links:
The Youth@Work website is part of EEOC's Youth@Work initiative - a national education and outreach campaign to promote equal employment opportunity for America's next generation of workers. For more information please visit www.youth.eeoc.gov


text:
Color: Atomic Orange/White/Pure Platinum
6 Month Outsole Warranty
Average weight: 12.1 oz. (Size 8.5)
Nike Air Max cage
lin mckee from PA wrote (August 07, 2014):
Love the look, extremely stable, very comfortable. Roomy toe box so I ordered 1/2 a size smaller for a perfect fit.
Item #: 554874-801


text:
Crock-Pot Greek Chicken (for Salads or Pita Sandwiches)
Prep time:
Cook time:
Total time:
Serves: 4
Serving size:
- 1 Small Onion, sliced
- 2 Chicken Breasts (cut in half, frozen is fine!)
- 1 Teaspoon Olive Oil
- ½ Teaspoon Oregano
- ½ Teaspoon Garlic Powder
- 1 Teaspoon Lemon Seasoning (I used a Weber Zesty Lemon blend)
- ½ Teaspoon Salt if Lemon Seasoning is Salt-Free
- 1 Tablespoon Lemon Juice
- Put sliced onions on the bottom of the dip sized Crock-Pot.
- Add chicken, and cover with the remaining ingredients.
- Turn Crock-Pot to low for 4-6 hours, until chicken is tender enough to shred with a fork.
- Remove chicken to shred with two forks and return to Crock-Pot.
- Mix chicken with onions and liquid.
- Use chicken as filling in pita sandwiches with tomatoes, lettuce, and tzadziki sauce OR as topping on a Greek salad with a bed of greens, your favorite veggies, tzadziki sauce and pita chips*.
* I used the toaster oven on broil setting until crisp to make my own pita chips from sliced multi-grain pitas and topped with cooking spray and my favorite seasonings.
Linked up at the Old Fashioned Recipe Exchange!


text: With its easy elegance, this turtleneck sweater dress is certain to be worn again and again. The silhouette appears tailored to the body, despite it being knitted from slightly lustrous rayon and nylon yarns. The shape, with its dropped waist and pleated bottom, is effortlessly feminine with a vintage feel. Pointelle and ribbed details add intricate textures to this dress, while a hint of stretch maintains the impeccable fit. So chic worn with tights and boots now, and over bare legs in early Spring. Fits true to size and fully fashioned.


text:
Meet local Massapequa singles in your area by filling out our quick registration form. Once inside you will be area to search thousands of single Massapequa members. Personal ads of singles in the Massapequa area will be at your fingertips and with our new matchmaker service you will receive new matching members in your email inbox on a weekly basis. Find the best Massapequa singles when joining our online dating service today!
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text:
Cath Kidston floral white cotton plimsoles
All you fellow Londoners out there dealing with the tube strike, I commiserate. I also wish to impart some (yes, rather obvious) wisdom to all those who are making their way to and from work today and tomorrow and that is: wear some comfy and rainproof walking shoes! Don't do as I did this morning and wear your silly old ballet flats, as when you have to walk across London in the rain, you'll find this isn't the best idea going...
I'm wishing I had of thought of this earlier and arranged to have had these cute Cath Kidston plimsoles on my feet instead. They look like they could withstand a bit of walking and even though they're no waterproof wellies, they'd probably do better to keep the rain out than my pumps. Very cute, too! They're £16 from Cath Kidston.
Related: Cath Kidston floral print wellington boots | Turn your shoe heap into shoe heaven with Cath Kidston's shoe tidy!


text:
Marisa Miller's 'Guitar Hero' Ad Banned for Being Too Racy
Wednesday 16 June By Tom Cullen
The Furor About Michael Jordan's Fuhrer
Wednesday 16 June By Dr. Abraham J Froman
Terrifying Dog Smiles May or May Not Sell Dog Food
Friday 07 May By Emerald Catron
Belgian Condom Ad Will Motivate You to Wrap It Up
Thursday 29 April By Asylum Staff
Japanese Plan to Deal With Global Warming Seems to Involve Shaving Bears
Friday 02 April By Asylum Staff
Sex, Career Can Be Incredibly Difficult for a Man With Small Hands
Thursday 04 February By Asylum Staff
Taco Bell Founder Dies, We Remember Great Moments in Bell History
Tuesday 19 January By Ian Fortey
City Residents Waste 270,000 Pounds of Food a Day
Monday 21 December By Lisa Freedman
Is This Bleeding Traffic Safety Ad Effective?
Wednesday 08 July By Jeremy Taylor
Enter the Ludicrous World of Japanese Nicolas Cage Ads
Wednesday 01 April By Asylum Staff
Padma Lakshmi Does Food Porn
Friday 27 March By Jeremy Taylor
Ads Make TV More Pleasurable
Wednesday 04 February By Jeremy Taylor
Like in America, Foreign Beer Makers Use Sex to Sell Suds
Tuesday 02 December By Asylum Staff
Commercial Reminds Us What Women Really Want
Friday 29 August By Asylum Staff
Sexy Ads -- The Raciest Sales Pitches You've Ever Laid Eyes on
Thursday 21 August By Jeremy Taylor
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text:
From Proteopedia
|3ley, resolution 1.99Å ()
|Non-Standard Residues:
|3les, 3lev, 3lex, 1tji
|FirstGlance, OCA, PDBsum, RCSB
|save as pdb, mmCIF, xml
2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 6a7 in complex with HIV-1 GP41
Elicitation of antibodies against targets that are immunorecessive, cryptic, or transient in their native context has been a challenge for vaccine design. Here we demonstrate the elicitation of structure-specific antibodies against the HIV-1 gp41 epitope of the broadly neutralizing antibody 2F5. This conformationally flexible region of gp41 assumes mostly helical conformations but adopts a kinked, extended structure when bound by antibody 2F5. Computational techniques were employed to transplant the 2F5 epitope into select acceptor scaffolds. The resultant "2F5-epitope scaffolds" possessed nanomolar affinity for antibody 2F5 and a range of epitope flexibilities and antigenic specificities. Crystallographic characterization of the epitope scaffold with highest affinity and antigenic discrimination confirmed good to near perfect attainment of the target conformation for the gp41 molecular graft in free and 2F5-bound states, respectively. Animals immunized with 2F5-epitope scaffolds showed levels of graft-specific immune responses that correlated with graft flexibility (p < 0.04), while antibody responses against the graft-as dissected residue-by-residue with alanine substitutions-resembled more closely those of 2F5 than sera elicited with flexible or cyclized peptides, a resemblance heightened by heterologous prime-boost. Lastly, crystal structures of a gp41 peptide in complex with monoclonal antibodies elicited by the 2F5-epitope scaffolds revealed that the elicited antibodies induce gp41 to assume its 2F5-recognized shape. Epitope scaffolds thus provide a means to elicit antibodies that recognize a predetermined target shape and sequence, even if that shape is transient in nature, and a means by which to dissect factors influencing such elicitation.
Elicitation of structure-specific antibodies by epitope scaffolds., Ofek G, Guenaga FJ, Schief WR, Skinner J, Baker D, Wyatt R, Kwong PD, Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7. Epub 2010 Sep 27. PMID:20876137
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3ley is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
- Ofek G, Guenaga FJ, Schief WR, Skinner J, Baker D, Wyatt R, Kwong PD. Elicitation of structure-specific antibodies by epitope scaffolds. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7. Epub 2010 Sep 27. PMID:20876137 doi:10.1073/pnas.1004728107
Proteopedia Page Contributors and Editors (what is this?)
Categories: Mus musculus | Baker, D. | Guenaga, F J. | Kwong, P D. | Ofek, G. | Schief, W R. | Skinner, J. | Wyatt, R. | 2f5 | Envelope protein | Epitope | Gp-41 | Graft | Hiv-1 | Immune system | Monoclonal antibody | Re-elcitation | Scaffold | Transplant | Vaccine design


text:
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|2 1/2
|heavy whipping cream
|well chilled
|powdered sugar
|cocoa powder
|zest (see note)
|or Tia Maria, coffee flavor, such as kahlua
|cocoa powder
|unsweetened, for garnish*
Pour cream into a well-chilled mixing bowl.
Beat in an electric mixer fitted with chilled beaters or whip attachment.
Stir in the confectioner's sugar and cocoa and beat on medium speed until the cream begins to thicken.
Add the coffee zest and liqueur.
Continue whipping until cream reaches the soft peak stage, and remove from the mixer.
Finish beating by hand using a wire whisk, whipping until cream is quite thick but not grainy.
Note: to make coffee zest, add 3 parts coffee crystals to 1 part boiling water.
To assemble the cake, split each layer into halves.
Set the first layer on a serving plate, top side down.
Fit a 14-inch pastry bag with a large number 5 plain tube, and fill it 1/3 full with mocha whipped cream.
Starting 1/2 inch from the edge, pipe a circle of cream around the top of the layer.
Fill center of the circle with additional cream, smoothing surface with a large metal offset spatula.
Repeat with the second and third layers, placing them cut side up.
Arrange the top layer cut side down, aligning layers so the sides of the cake are even.
Empty the remaining whipped cream into the pastry bag.
Pipe 1/2 inch whipped cream dots on the top layer, beginning at the outer edge.
Each dot should touch the preceding one, forming a ring.
Continue working toward the center of the cake until the entire surface is covered.
Place 1/2 tsp cocoa in a very fine mesh strainer.
Gently tap the strainer over the surface of the cake to give it a light dusting of cocoa.
Place the cake in the refrigerator uncovered to chill, but remove from refrigerator at least 1 hour before serving.
Storage: Store leftover cake in the refrigerator under a foil tent.
This cake will keep for up to three days.
First published: 1996-01-27 last updated: 2013-04-20
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East Ridge Officer Sean MerrimanPhoto by Contributed Photo /Chattanooga Times Free Press.
An East Ridge police officer will appear before a judge as a suspect in a Friday hit and run.
The accident happened early in the morning at the 8100 block of Blue Spruce Drive in Middle Valley. The Hamilton County Sheriff's Office, which has investigated the case, followed a fuel trail that led from a damaged truck to Officer Sean Merriman's 2004 Jeep Cherokee.
Merriman has been cited with leaving the scene of an accident. He is slated to appear in Hamilton County Sessions Court on May 21.
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Lil Wayne Says He Is Unaware Of Backlash To New York Comments
Lil Wayne says he is clueless to the backlash against his comments towards New York.
Lil Wayne got under some people's skin when he said that he "flat out" doesn't like New York City, New York. After facing some backlash for his comment, Weezy spoke to MTV News about the response, stating that he doesn't pay any attention to what others are saying and that he's completely unaware of how people interpreted his words.
"I have to be honest with you, dog: All I do is work, and I swear to God, I don't even know the reaction," said Wayne. "If I knew the reaction I'd know how to be able to answer that question, but I don't know the reaction. I just say what I want to say, do what I want to do and fuck who don't like it."
He also said he hadn't heard Fabolous' "So NY," which responded to the comment with the rhyme, "I'm so New York, Weezy probably don't like me." "Nah, I don't listen to nothin' else but myself, 'cause I'm just tryin' to get better," he said. "I always listen to what I could've said or done better, so I'm sorry."
RELATED: Cory Gunz Talks New Mixtape, Collaboration With Lil Wayne For "I Am Not A Human Being 2"
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The Beloved Hotel Rating: 5.0 Pearls
The ultra-luxe Beloved, on a white-sand beach, features 109 suites with super sexy decor. They're all-white, with spacious, sleek marble bathrooms and Jacuzzi tubs, and have the vibe of a luxurious New York City hotel room -- except they're about four times the size and feature private balconies, many with ocean views. The expansive spa and fitness center are great, and the two pools with food and drink service are large and attractive. There are four restaurants, but most of them are not open all hours and service can be slow. Another downside is that the beach is often strewn with seaweed, and many guests have complained that the pool water is much too cold. The Beloved Hotel and Excellence Playa Mujeres have a very similar vibe and level of luxury, so travelers may want to compare prices before booking.
Hotel Villa Rolandi Thalasso SPA - Gourmet & Beach Club Rating: 4.5 Pearls
The Hotel Villa Rolandi is a romantic, 35-room boutique that fully embraces the "less hectic than Cancun" vibe of Isla Mujeres. Two big draws are the secluded location on a small white-sand beach and the "no children under 13" policy. All rooms are spacious suites (the smallest starts at 498 square feet) that offer flat-screen TVs, large balconies with private Jacuzzis, and Italian marble floors. Great perks include a free continental breakfast delivered to rooms at no extra charge, and a 42-foot yacht that provides free transportation to and from Cancun.
Isla Mujeres Palace - All Inclusive Rating: 4.0 Pearls
This 62-room all-inclusive, couples-only boutique hotel is located on a white-sand beach in the southern part of Isla Mujeres. It features all the standards of larger resorts -- a nice pool with a swim-up bar, non-motorized water sports, balconies with ocean views -- but on a smaller scale and with a more intimate vibe. Airy rooms are luxurious and elegant with Jacuzzis for two, furnished balconies, flat-screen TVs, and free Wi-Fi. There is one restaurant here with a somewhat limited menu. Perks at this hotel include a lack of crowds -- no fighting for pool chairs here -- along with a nice fitness center, spa with four treatment rooms, and quiet beach.


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|DIY Tree Swing
|DIY Projects
Building a tree swing out of timber and natural materials can be a fun DIY exercise for you and the family will guarantee many years of enjoyment. Nothing is more reminiscent of old-fashioned, backyard fun than a tire swing. Children love the swinging motion and being outdoors is the healthiest entertainment.
A Timber Tree Swing By John Vivian
Build a tree swing and feel like a kid again! My childhood was graced with an older generation that knew how a kids' swing ought to be built. No flimsy metal frame sets with cramped plastic seats hung on thin, palm-cutting clothes line. No thigh-squeezing rubber slings on finger-pinching chain either. Instead, there were stout wood seats that little knees could lock on to, and boat-mooring line, suspended from sturdy tree branches, and that was fat enough to give a firm grasp. At the old family homestead, a swing at the river bank was fastened so high that the rope disappeared forever into the canopy of a huge black oak. Pumping hard, we could swing 15 feet above the water ... let go and fly almost to midstream ... and land in a cannonball worthy of the name.
I've built old-style swings on my own country places for over 20 years now. I can tell you that an awful lot of children (and adults) have shared the joy of swinging and creating a nice breeze during those sticky summer days. There's a real pride in knowing I helped to put those smiles there — a pride everyone should know. So I've decided to teach all of you the craft of building a sturdy swing that your children and grandchildren will remember you by.
There's several materials that go into building a tree swing. You'll need a hand saw or electric Skilsaw (try square or other right angle), wood rasp, sandpaper, screwdriver (an electric power driver is best), a drill with 1/8" and 3/8" wood-bits, lumber, rope, fasteners, fittings (as specified), plus a can of wood preservative and a brush. However, you'll need no great carpentry expertise, and I'll demonstrate some marlin-spike seamanship so that you can fasten the rope securely.
First, there's the matter of picking the right tree. You should look for one that is in open ground, and that has a thick, live-wood limb which is growing parallel to (and not inaccessibly high off) the ground. A limb much less than ten inches in diameter will bounce, reducing the young swinger's stability. A solution might be to attach the swing close to the trunk, but too close and the swing will carom off it. Deadwood branches will break, and limbs that angle upwards will skew the arc of the swing.
The higher the limb, the longer the swings pendulum motion and the higher it can go before gravity overpowers momentum. Playground swings are six to ten feet high, and a grade schooler can get five to six feet above the pavement. Your yard will provide a softer landing for any slip, and your swings ropes can be attached fifteen feet off the ground to give a good but not too-high ride. For a real cloud-duster, you can send a good tree climber up to fasten your ropes to a limb 25 feet or more high. Make a point of supervising those children under 12 years of age. Measure or estimate the height of the limb off of the ground. Then go to a quality lumber yard and a good hardware store and purchase the following weather-resistant materials:
Wood Measure sure six feet of nominal 4/5" thick, 6' wide (actual measure: 1 1/16" thick and 5½" wide) #2-grade Eastern white, Western red cedar, or California redwood decking, preferably with "eased" or rounded edges. If these naturally rot-resistant, non-splintering woods are not available, buy white oak or an other hardwood if you can. Common two-inch-thick construction softwood lumber is okay. It's thick and splintery but definitely better than thin, easy splitting, 1" pine shelving. Don't think of using deck boards of that colored, pressure-treated wood — you don't want a splinter containing arsenic or copper preservative in your child's tender bottom.
Screws: For an electric power-driver, you'll need 26 #6, 1 7/8"-long galvanized deck screws ($.10 apiece); for hand-driving, use 26, #6, 1 7/8" brass screws ($.25 each).
Twine: You'll need several feet of 1/16" thick 20 to 30 lb nylon twine.
Build The Seat
The seat is made from a pair of narrow boards (a single, wide board might split). It is ten inches deep and 16 inches wide to offer young children an ample seat, a good leg hold, and a snug, safe fit. If your kids are broad in the beam, or the swing is going to be used by older teens and adults, cut the seat boards 18 inches long.
1. Two 16" long seat boards. Rip-saw 1/2" off the roughest long edge of each board.
Fasten Cleats To Seat
Place the seat boards on a flat scrap lumber surface with the cut edges facing one another. To provide a drainage slot, place the spacers of cardboard (from the back of a writing tablet) between them at the ends and the middle.
1. Spread glue on one side and then place the cleats. The center cleat should be in the middle and the end cleats should be inset a half-inch from the edges of the seat. Clamp or weight in place.
Drill Rope Holes
1. To locate the rope-attachment holes, draw a faint pencil line 1½" in from (and parallel to) the ends of the seat top. Make a pencil mark 1½" from the end of the lines. Make a dent at the pencil mark with a nail or punch to center the drill.
Attach Ropes
The swing-ropes are attached to looped rope slings at each side of the seat. The slings give a snug hip-hold, and offer the swing greater stability; it can't tip forward or backward and dump a child who might be swinging too enthusiastically. And a small child can pull against the forward rope for better leverage.
The Rope Slings
Cut two 5-foot lengths of rope. Tape cut the ends or sear with a match until the ends melt so that the rope won't unravel (be careful not to breathe the smoke or let the hot, melted poly burn you).
Thread the rope ends down through holes in the seat, slip washers over each end. Now, leaving a good four inches of tail, tie simple but self-tightening overhand "granny" knots in all four ends. Adjust the knots until the slings are of equal length. With the fence staples, tack the tail of each rope to the end cleats.
Then, cut off and sear the ends of four two-foot lengths of the 1/16" nylon twine. Locate the center of each seat rope sling, and twist 180 degrees into a 1-inch loop. Untwist the sling ropes where they cross just enough to open the strands. Then thread twine through both, and twist them back tight. Pull one end of the twine short (about six inches). Tie the twine ends tight to hold the loop together.
Now, bind (in nautical jargon, "whip") the loop together where the ropes cross. Form the short end of the twine into a loop with a good tail. Binding in the tail of the twine loop as you go, wrap the long end as tight as you can a dozen times around the "X" where the rope crosses below the loop. Thread the end of the wrapping twine through the twine loop, then pull the end of the loop's bound-in tail until the loop disappears under the wrapping. Trim and sear the loose ends of twine. Nylon twine is limp, and keeping it tight it takes dexterity, but with a trial or two you will lay on your wrapping tight and evenly spaced, ending up with a seaman-like rope eye or "Becket":
Attach Rope to Limb
Fasten the swing ropes seventeen inches apart on your tree limb. (Spacing the ropes a bit wider than the seat gives lateral stability so the swing won't skew or twirl easily. If the kids are small, and you want to reduce and further stabilize the swings travel, experiment with even wider spacings.) Where it circles the limb, you may want to run the rope through a length of old garden hose to protect a thin bark such as beech, or notch rough hickory or maple bark to keep the rope in place.
For easiest attachment, toss the rope over the branch, throw a "bowline" knot in one end (see the illustration: Knots) leaving a three inch tail. Then, for good measure, whip the tail to the adjoining swing rope. Pass the other end of the swing rope through the loop and cinch what is now a running bowline tight up on the limb.
An even better method is to attach the ropes to the eye screws in the limb. Drill 1/8" pilot holes 17 inches apart on the under side of the limb; insert a screwdriver in the eye screws and turn them into the holes. Then make whipped-tail bowlines in one end of the rope and hang it from the eye screws with secure, but dis mountable "S" hooks. This way you can unhook the swing and store it over winter. Keep those rubbing metal parts (which are up at the tree limb) greased and the swing should last for generations.
Attach Rope To Seat
Attach the free end of the swing ropes to the Becket's that are in the seat rope slings with a Becket bend. Take your time to loosen and adjust the knots so that the seat is level and at the best height. Remember, you want your children to be able to reach the ground with the balls (but not the heels) of their feet. (Hint: For a 7-year-old, a seat top 13" off the ground is about right.) Push the whipcord holding the sling Becket up under the loop in the Becket bend, tighten, and whip the loose end of the knot to the swing-rope.
This simple-looking but self-cinching knot will hold forever, even in slippery artificial-fiber rope. But when the kids grow a few inches, you can cut the binding, loosen the knot with a push, raise the swing and rebind. Check the knots until the rope sets over a few month's use. If your knots or bindings persist in coming loose, avoid shipping out on a sailing vessel any time soon and spray with an all-purpose, water-resistant adhesive. The wood will weather to a dusty gray in time and, with annual applications of wood preservative, should last until your grandchildren have grandchildren of their own.
Finally, a comment on swing safety:Centrifugal force will hold kids on the seat as long as they don't go so high that the rope slackens at the top of the swing. Accidents are limited to occasional scratched knees and stubbed toes at the landing zone under the swing if kids are given a non-slippery seat, rope they can grasp, plus training and supervision. Teach them to hang on tight with both hands and to swing straight and not too high. And, prohibit tricks, while swinging high (no twisting the rope, hanging ape-like by one arm, no standing on the seat or letting go to to sail off onto the ground). Scrapes are minimized if kids are dressed in tough jeans and shoes. (Little girl's dresses are not safe swing-apparel. Silky under drawers can slip off dress fabric, and send kids sprawling to the ground. Bare knees are vulnerable.)
It's easiest on shoe leather if kids are encouraged to "let the dog die" rather than scruffing themselves to a stop. And, never let grown-ups or older youngsters push younger children higher than they like to go.
DIY Tire Swing
Recycle an old tire and make a simple vertical or horizontal apparatus for hours of outdoor fun.
Here are two types of simple tire swings, vertical or horizontal. The vertical is more suitable for a solitary swinger, while the horizontal allows more than one child to swing.
Choose Tree for Swing
Prepare the Tire
For a vertical tire swing, you will need enough rope to reach the distance from the tree to the swing, pluLight truck tires work well, but bigger, heavy truck tires used on semis can cause harm. Avoid steel-belted radials, which can pose cutting hazards.
Pad the ground beneath the swing with wood chips, bark or recycled-tire rubber tiles.
Easy Vertical Tire Swing
Simple Horizontal Tire Swing
Drill about three drain holes in the bottom of the tire. Then, drill three holes, equidistant, and from top to bottom of the tire. Thread the ropes through the drilled holes and through a washer and then tie a secure knot.
A simple DIY Tire Swing
Cut the rope to the desired length. Measure from the branch to the height you want the swing to be, and add a little extra for knots.
Enter the rope into the hose, making sure the hose will rest on top of the branch to protect the branch and your rope.
Drill a big hole at the bottom of the tire so the rain can drip away ...
Throw the rope over the branch placing the rubber hose on top of the branch and tie it up. Leave some space open.
Get someone to hold the tire at the desired height (or something) and tie the other end of the rope to your tire.
Check the capacity of your swing. A thicker branch, closer to the trunk, can support the most weight.
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Marshall McLuhan 1964CLICK HERE for more quotes


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The Israeli Hacktivists' Cyber War in Gaza
Late Thursday night, as Israeli tanks advanced into the Gaza strip, civilian Israelis gathered to fight alongside them. The frontline, however, was virtual, the battlefield digital. Soon after Israeli soldiers crossed into Gaza, the hacktivism group the Israeli Elite Force (IEF) recruited an army of volunteers. The Hashtag for the operation was #OpIsraelRetaliate and the chosen targets were official Palestinian websites.


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Enter your username and password to sign into your account.
In Spring 2013, the WEMTA Board approved a plan to reactivate the Intellectual Freedom Committee (which had been disbanded in 2008).Carin Bringelson is the Intellectual Freedom Committee Chair, 2013-2015. Besides the committee, there are also the following Intellectual Freedom resources in WEMTA:
These and other WEMTA intellectual freedom activites, as well as additional resources, can be found under the IF links on the left.
If you have an IF concern, we encourage you to contact an IF Network member. If you are facing an actual or potential book challenge, we encourage you to contact the Cooperative Children's Book Center Intellectual Freedom Information Services.


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Contact: Science Press Package
American Association for the Advancement of Science
Caption: Jay F. Storz, University of Nebraska. This image relates to a paper that appeared in the June 14, 2013, issue of Science, published by AAAS. The paper, by Chandrasekhar Natarajan at University of Nebraska in Lincoln, NE, and colleagues was titled, "Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin."
Credit: [Image courtesy of Brent Hampton]
Usage Restrictions: Please cite the owner of the image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission.


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Microsoft confirms March 14 release of Internet Explorer 9
It sounds like the party will be pretty wild, with live music from Yeasayer, the Head and the Heart, and Fences. We're told that over 1,500 people will be attending (but unfortunately Download Squad can't make it).
There's a fun video of Ryan Gavin and Dean Hachamovitch, the Corporate Vice President for Internet Explorer, discussing the browser's upcoming release after the break.
If you haven't read our IE9 guide yet, you now only have five days before the final build is released, so hurry up!


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"Because breathing shouldn't be a struggle or a risk"We at Breathe California are actively advocating for policies that promote clean air and improve lung health in our communities. Our legacy of advocacy work spans decades and includes the implementation of the 1970 Clean Air Act and the Prop 99 tobacco-tax in California. We continue to be a key advocate of landmark state and federal legislation on air quality and lung health issues.
As a community-driven grassroots organization, we welcome input from our community members to determine necessary legislation and policy change. Breathe California then amplifies our communities' voice to hit every level of policy implementation. Our local team of policy experts advocate for air quality and lung health improvement in all nine Bay Area Counties. Over the last five years alone Breathe California has participated in an average of:
- 350 in-person meetings with policy makers each year;
- 175 collaborative and collaboration meetings each year,
- 45 formal public testimonies at hearings each year.
We have seen many successes, but there is much more to do. Lung disease is now the 2nd leading cause of death in America. As we strive for a world free of lung disease, with your support and participation we are determined to tackle these challenges.
Become a Breathe California Advocate today! Learn more about our breadth of advocacy work in:
Policy Accomplishments and our Air Quality and Lung Health Partners
!Join Our Advocacy Network Breathe California is making a difference by advocating for lung health issues and acting as a model for the nation...but we can't do it without you. In addition to our local grassroots programs which promote lung health, we are working on state and national levels to help shape policy and pass legislation supporting our vision of healthier communities and cleaner air. Members of our Advocacy Network will be able to sign petitions and send web messages to their legislators about policy issues that Breathe California is focusing on. Become a [http://salsa3.salsalabs.com/o/50701/p/salsa/web/common/public/signup?signup_page_KEY=7748|Breathe California Advocate] today. {HTML(wiki="1")}
{IMG(src="display390",imalign="left")}{IMG}"The most proud that I've been as a Supervisor with my ten colleagues on the San Francisco Board of Supervisors is in developing policy from the bottom up. Breathe California and our environmental justice organizations have really been wonderful, making it easy for policymakers like me so that we use local policymaking to really promote leadership and a brighter future for everyone."{HTML} !A History of Leadership in Public Health{IMG(src="display149",imalign="right",class="padbord")}{IMG} Since 1908, with the help of thousands upon thousands of individuals like you supporting us, we have worked to prevent lung disease and promote lung health in the San Francisco Bay Area and beyond. Since our founding as the San Francisco Society for the Study of and Prevention of Tuberculosis, we have been at the forefront in support of research, education and advocacy to eradicate lung disease. !Tuberculosis Through education, prevention, treatment and research, we played a key role in containing the TB epidemic by the mid-1900s. Today we continue to advocate for adequate funding of TB control services, as tuberculosis remains one of the leading causes of death by infectious disease worldwide. !Tobacco Control Since the 1980s we have been leaders in advocating for smoke-free workplaces, restaurants, bars, parks, golf courses, farmers markets and multi-unit housing. Breathe California staff have provided leadership to local county tobacco control coalitions. !Clean Air Advocacy With the help of a strong grassroots effort we have been instrumental in the adoption of clean vehicle policies for city and county fleets, the removal of dirty diesel school buses, wood smoke control and adoption of clean truck and construction regulations in California. Today we continue to fight against threats to regulations that protect clean air and reduce green house gases. !Asthma Advocacy In addition to our ((Asthma Education)) programs, we have advocated for policies to reduce the burden of asthma in communities, including instituting asthma action plans for students in schools and daycare, increasing carpet-free and smoke-free units and assisting with mold identification in public housing. !Research Since the early 1900s we have made research a top priority in our fight against lung disease. We continually advocate for increased funding for lung disease research on the state and ((COPD Advocacy|national level)). !The Fight Continues We have seen many successes, but there is much more to do. Lung disease is now the 2nd leading cause of death in America. As we strive for a world free of lung disease, we are determined to confront these challenges with the same commitment and determination we used to curtail the tuberculosis epidemic of the 1900s.
- Supervisor Eric Mar
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Originally posted 06/22/2011 09:30PM
Christina Aguilera, Blake Shelton, Cee Lo Green and Adam Levine have their finalists on The Voice.
After the top eight contestants performed the night before, the results (a combination of judges' scores and viewers' votes) were announced on Wednesday.
Keep reading to find out who made the first-ever final four on NBC's hit show.
Originally posted 02/14/2011 10:55AM
Blake Shelton says Valentine's Day with fiancée Miranda Lambert probably won't be too passionate this year – and it has nothing to do with her forgetting to thank him at the Grammy Awards.
"The Grammys have kind of screwed up Valentine's Day for everybody here," the country singer, 34, told PEOPLE at the music-awards show on Sunday. "We're all going to get wasted tonight. I mean, we are. And we're going to feel like crap. The last thing we're going to want to do tomorrow is touch each other."
For her part, Lambert, 27 – who won Best Female Country Vocal Performance for "The House That Built Me" – said she's still expecting Shelton to step up today.
Originally posted 02/04/2011 09:00AM
Miranda Lambert has a lot to be happy about: a sexy fiané, multiple Grammy nominations and her recent weight loss, to name a few.
So what's the problem?
"Being happy is horrible for songwriting, especially for country music. We just want to write about leaving and sadness," Lambert, 27, says in the March issue of Ladies Home Journal. "I have to put myself in a dark place if I want to write something good."
Originally posted 08/18/2010 03:30PM
How does country star Jewel keep her figure in tune? Mesquite-smoked Texas-style barbecue.
Okay, maybe that's not her most tried-and-true diet tip, but the country singer certainly has a go-to barbecue joint: Hard 8 BBQ in Stephenville, Texas.
"I take all my out-of-town guests here, and they rave about it," she tells PEOPLE Country in its September issue. "In fact, I think they visit me just for the barbecue."
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Garner totes her birthday boy, son Samuel, through Brentwood, Calif. Plus: Michelle Williams, Mila Kunis, Prince Harry and more
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They've got class – no, really! Sarah Jessica Parker teaches her backpack-rocking son James, 10, a thing or two about N.Y.C. street style before school on Tuesday.
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Friday, 22 February 2013 00:00
More than month has passed since our beloved son, brother, uncle and brother-in-law, Nunzio Izzo, was murdered. I would like to thank the community of Glen Cove, Mayor Ralph Suozzi and his administration, the Glen Cove Police Department including Lt. Det. Nagle, most especially Detectives Van Allen and Albin, and Nassau County Detective Nardo. Together they all worked long and hard to help solve this senseless crime. They should all be congratulated for outstanding work on this case.
Words cannot describe the outpouring of love and support from our relatives, friends, and the entire community of Glen Cove. We have suffered a tragic loss that can never be replaced and will never be forgotten.
On behalf of my wife, myself and my family and the entire Izzo family I want to thank everyone for their love and support and may God continue to bless you.


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1 person found the following review helpful
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This is a collection of soaked sprouted grains and seeds with apricots. It is very crisp and is actually very good. I use it with coconut milk. It is delicious and very filling. However, it has to be eaten slowly and chewed thoroughly because the ingredients are on the hard side. I haven't tried this, but I think putting liquid over it several minutes before eating might make it easier to eat as it would soften the seeds and grains. I also add a few raisins to the mix. I think dates would also be a good addition. I will buy more but I think I will do a lot of experimenting with it by adding some of the above ingredients plus coconut, walnuts and maybe even some fresh fruit. It is good and filling.
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Posted by MichelX on Aug 27, 2012
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One of my two favorites of Lydia's cereal. The other is Vanilla Crunch. They are filling and pure. The price is waaaaay better than the other Raw sprouted cereal brand, although that one is tastier, however it has added sweeteners. This is pure and better for dieting or those who prefer unsweetened.
Apricot sun cereal
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Loved it as a snack or with yogurt. Healthy fiber intake, not too sweet as I like. Good fill up in a evening when you have no idea why you're hungry. I'm not sure I'd eat it with milk like regular cereal, but have not tried. Has a sunflower seed in it. Kids did not like it, said it tastes too healthy :)).
Posted by Scottishdave on Aug 08, 2011
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My favourite of the Lydia's cereals. All sprouted grains mean i can now digest the seeds and nuts.
Best Lydia's Cereal
Posted by Reviewer1010990 on Aug 26, 2011
Purchased at iHerb
I love this cereal and the bits of dates mixed in ... plus, it's low in sugar, high in fiber, and not too high in calories. I stir it into yogurt for breakfast, and I feel great all morning long!


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Hemsworth steps out in Los Angeles. Plus: Olivia & Jason, Kim Kardashian, Lindsay Lohan and more
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A day after hanging with Minnie Mouse, Sarah Jessica Parker gives her mouse ears to daughter Tabitha, 3, who gets in the holiday spirit for her ride to school in New York on Thursday.
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Rocks Off Sr.'s choice for 1991's best album.1991 was one of the biggest years in modern music. It was when metal went pop, radio country ruled, grunge went mainstream, and rap began its climb to chart dominance, even if it was spearheaded by a white candy rapper from Dallas. There were man ... More >>
Marco TorresEditor's Picks: Mary J. Blige, Reliant Stadium (RodeoHouston), March: Exquisite. Beach House, Walter's on Washington, April: Can't hate on this one either. Magical. Wu-Tang Clan, Numbers, December: Against all odds, they brought the motherfuckin' ruckus.
Four artists share their guilty, and not-so-guilty, pleasures
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Merge and Matador reach ten years of indie success


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A team led by Dr. Haim Cohen, of Bar-Ilan University's Mina and Everard Goodman Faculty of Life Sciences, and including researchers from Hadassah Medical Center, the Hebrew University, and Carnegie Mellon University, has discovered a gene that increases survival in mammals. The discovery increases the likelihood that similar activity can be found in a human gene.
Many genes that affect the lifespan of laboratory animals have been discovered recently, and researchers are focusing on a group of these genes, known as Sirtuins. Sirtuins can be found in every species developed over the course of evolution and are, in one way or another, found in single-celled organisms, such as yeast, and in complex organisms, such as humans. The most highly researched gene in this group is SIR2 (Sirtuin 2) which has been found to prolong life in yeast, worms and flies. If this gene is removed from yeast cells, the yeast cells age faster and live a shorter life. But if a copy of the gene is transplanted into the yeast, their life expectancy increases. Similar phenomena also occur in worms and flies.
Preservation of the SIR2 family of genes during evolution indicates the importance of these genes in critical life processes. In each organism in which SIR2 has been found, the gene regulates lifespan, but this was yet to be proven in mammals. Last year there were many reports in scientific literature on the extent of their involvement in the lifespan. More than thirty research groups debated the issue in the pages of the leading scientific journals Nature and Science, but a final conclusion was not reached.
Research of the SIR2 gene in mammals yielded a set of seven genes — Sirtuins 1-7 or SIRT 1-7 – each of which works in key reactions in the process of life. Do any of them bring about extended life in mammals? This is where Dr. Cohen's research steps in. Cohen examined gene number 6 from the Sirtuin group (SIRT6) in mice. He used two groups of mice. In one group SIRT6 was removed from the mice and in the second group he created an over-expression of the gene in mice.
"Originally in mice without the gene, researchers saw premature aging," says Cohen. "They suffered spinal curvature, calcium deficiency and osteoporosis, immune system problems, and diabetes — conditions which are familiar to us in aging humans. We called the second group, which we created in the laboratory, the 'MOSES' mice (an acronym for mice over-expressing exogenous SIRT6), and compared their lifespan to that of wild-type mice, which possess a normal amount of SIRT6."
Cohen and his team fed two groups of wild-type and MOSES mice a high-fat diet containing 60% more fat calories than average. The wild mice developed the diseases associated with aging, while the MOSES mice remained healthy. MOSES bodies contained 30% less fat, about 40% fewer triglycerides (which increase cholesterol) and 30% less diabetes compared to the MOSES mice. Concerning lifespan, wild strain female mice usually live longer than males. In the tests conducted by Cohen on 250 wild and MOSES mice, they found that with normal diet the MOSES male mice lived 15% longer than the male wild species. However, among the MOSES females, no change was recorded. What, then, gives the females a longer life expectancy?
"We found that the rise in life expectancy among males is based on the calorie restriction known to us as a basic mechanism of life extension. There is overlap between these pathways, and the SIRT6 gene is involved in it. Females from the very beginning have a longer life expectancy than males because the basic mechanism is already active, so the engineered males just catch up to females," concludes Cohen. "In the current study, published today, we've made a huge evolutionary leap in the transition from yeast cells to mice. We were the first to show that these sirtuin genes regulate life span in mammals. The research was conducted in laboratory animals under very sterile conditions. Is this what happens in nature? It's not clear. The human SIRT6 gene is very similar to that in mice. It could be that drugs designed to activate the gene will have a positive impact on our ability to treat age-related diseases whose frequency increases in the elderly and in the physiological damage caused by obesity."


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When Eva Mendes stepped out onto the red carpet for 'The Other Guy's premiere in Leicester Square last night, her demure Prada green silk faille dress with embroidered beading, was primly hiding what has become her trademark - that gorgeous hour glass figure. Eva's banging bod has so far landed her megabucks modelling contracts with Calvin Klein, to front the superbrand's jeans, lingerie and Obsession fragrances.
So it's no surprise that Mendes is amused to hear the fashion press declaring the "return of the hourglass" for Autumn Winter 2010; 'Well it's not news to me!' said the actress to Grazia Daily 'I've been making a living for years because I have an hourglass figure and curves! I don't think the trend has ever been away but it's great to see natural assets celebrated.'
We also wondered, with all those curvy lingerie models now making the leap from calendars to catwalks, would she ever consider modelling in a designer's fashion show if approached? 'No, I would never go near a catwalk unless it was for charity!' she told us, seemingly horrified 'there's no way I think the two worlds [acting and catwalking] should cross over; I do what I do as an actress but I don't think I would know how to walk - it's a skill. Let models get on with what they do well.'
Fair enough. Bet she's hanging on to those lucrative ad campaigns though.....
- Emma Pritchard Jones


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Facebook Gifts Deemed Promising and 4 Stock Analyses Making Rounds
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January 04, 2013
SodaStream International Ltd. (NASDAQ:SODA) Current Price 48.57
After conducting checks, Stifel Nicolaus is more confident in SodaStream International Ltd.'s first and fourth quarter U.S. sales based on lower inventories at some stores and new distribution outlets. The firm raised their estimates but believes that the consensus of first quarter earnings per share estimate does not account for the cost of the company's Super Bowl ad. They maintain a Hold rating on the stock.


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August 13, 2014
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Gov. Scott Walker rejected $810 million in federal funding for a high-speed train line between Madison and Milwaukee after he was elected in 2010, and the issue has continued to surface.
Earlier this month, a Chicago-based environmental group paid for a billboard along Interstate 94 between Madison and Milwaukee on which it urges the state to get "back on track" with high-speed rail. For the full story, click here.
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