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Pumpkin Pie Cupcakes
My family always asks for these cupcakes once fall starts. We just love the flavors of cinnamon and cloves—the shining stars in this dessert. —Melissa Story, Trego, Wisconsin
24 Servings
Prep: 30 min. Bake: 15 min. + cooling
1-3/4 cups mashed cooked
canned pumpkin
3/4 cup sugar
3/4 cup packed brown sugar
1/2 cup unsweetened applesauce
1/3 cup canola oil
2 eggs
2 egg whites
2-2/3 cups all-purpose flour
2 teaspoons baking powder
2 teaspoons ground cinnamon
1 teaspoon baking soda
1 teaspoon salt
1/4 teaspoon ground nutmeg
1/4 teaspoon ground cloves
1/4 cup butter, softened
1/4 cup shortening
1-3/4 cups confectioners' sugar
1/4 teaspoon ground cinnamon
1/8 teaspoon ground cloves
1/2 cup finely chopped walnuts
In a large bowl, beat the pumpkin, sugars, applesauce, oil, eggs and
egg whites until well blended. Combine the flour, baking powder,
© Taste of Home 2014
2 of 2
Pumpkin Pie Cupcakes
Directions (continued)
cinnamon, baking soda, salt, nutmeg and cloves; gradually beat into
pumpkin mixture until blended.
Fill foil-lined muffin cups two-thirds full. Bake at 350° for
15-20 minutes or until a toothpick inserted near the center comes
out clean. Cool for 10 minutes before removing from pans to wire
racks to cool completely.
In a small bowl, beat butter and shortening until fluffy. Add the
confectioners' sugar, cinnamon and cloves; beat until smooth. Spread
over cupcakes; sprinkle with walnuts. Yield: 2 dozen.
Nutritional Facts:
1 cupcake equals 229 calories, 9 g fat (2 g saturated fat), 23 mg cholesterol, 212 mg sodium, 35 g carbohydrate, 1 g fiber, 3 g protein.
© Taste of Home 2014


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Alleppey backwater cruising Alappuzha, India River CruisesKerala Canoe Tourism is situated in Alleppey – in the heart of famous back water resources of Kerala. Our main aim is to getting maximum customer satisfaction by providing a high quality & unforgettable cruising experience. ... $170 Per Trip
Houseboats KeralaAlappuzha, India River CruisesBack water tour alleppey kerala... $100 Per Night/Room
Houseboat Cruise in Kerala BackwatersAlappuzha, India River CruisesOurs is Houseboat built with Natural Wood & Fibre. There is fully furnished bed room attached with toilers, living cum dining rooom, kitchen etc. in the Houseboat. Houseboat cruise through the backwaters of Alleppy and Kumarakom in Kerala.... $120 Per Trip
Coco Houseboats, Alleppey , Kerala, IndiaAlappuzha, India River CruisesCoco House Boats operates romantic backwater cruises since 2000 having one bedroom houseboats, two bedroom houseboats, three bedroom houseboats, family house boats and also offers various backwater tour packages.
... $100 Per Night
Alleppey Houseboats @ $55* only.Book NowAlappuzha, India Luxury CruisesWe own Houseboats having 1bed ,2Bed,3Bed room houseboats in Alleppey to serve you the Nature on Backwaters cruise through our luxury Houseboats,Deluxe Houseboats & Our Premium Houseboats to enchant the beauty of sunset through Backwaters on Houseboat... $55 Per Night/Pers
Bed And Break In House BoatAlappuzha, India Bed & BreakfastsBed and breakfast in house boat ,activities -sunset watching,moon watching,night fishing,sunrise watching,-----fasilities-airconditioned room,satlite tv,uper duck balcony,...Starting at $100 Per Night/Room
Vembanad House-kerala Heritage Back Water HomestayAlappuzha, India Bed & BreakfastsVembanad House -Heritage Back Water Home Stay.,alappey,kerala,india
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Alappuzha Luxury Kerala HouseboatsAlappuzha, India Hotels & ResortsCosy House Boats operates kerala backwater cruises having one bedroom houseboats, two bedroom houseboats, three bedroom houseboats, four bedroom houseboats conference house boats and various backwater tour packages. please contact 00 91 98471 02160...Starting at 3,500 Per Night
Kerala KayakingAlappuzha, India Kayaking & CanoeingKerala Kaykaing is one & only company in alleppey who do the backwater kayaking tour in alleppey backwater .See the peaceful villages, smiling children and farmers hard at work. An excellent opportunity to see day today life of villagers, local peo... $22 Per Person
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Houseboat Cruise in Kerala BackwatersAlappuzha, India Eco ToursKerala Houseboats are made with natural wood & fibre. There is fully furnished Bed rooms attached with modern toilet, living cum dining room, kitchen etc. in the Houseboat. Houseboat cruise through the backwaters of Kumarakom & Alleppy in Kerala.... $100 Per Night
Terai Arc Landscape AdventuresGurgaon, India Eco ToursTerai Arc Landscape (TAL) the lowlands along the Himalaya mountain range in India & Nepal. The TAL is home to many endangered mammals including the Bengal tiger (of which it has one of the world's highest densities)& the Indian rhinoceros,...Starting at $100 Per Night
Village TourMumbai, India Eco ToursCalling all adventure tourists who would like to try something new, isn't it time we gave up playing virtual Farmville behind a computer screen and play it in reality instead ?
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subset: commoncrawl


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Houzz is the new way to design your home.
26 Batesville, IN Bedding and Bath Manufacturers and Retailers
Whether you're looking for the latest in bath accessories and products or hunting for luxurious custom bedding, you'll find a wide range of Batesville, IN bedding and bath manufacturers and retailers on our Professionals pages. More
Holder Mattress Co., Inc. (317) 848-2939
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Very cool Skyborn! I like!
I wasn't quite sure where to put this -- but for various reasons (including Cinder's recent frontpage postings on moviemaking) I decided to share something I cut together today.
[ame="http://www.youtube.com/watch?v=c9pfd4fCqqk"]YouTube - Sapphiron 1-Shot (HD)[/ame]
It's just a 2-minute highlight reel of my guild downing normal Sapphiron in one shot last night. I wanted to make something that looked good, had some energy and maybe was fun to watch. I know I enjoying putting it together.
This is not a guide video by a longshot Just me doing something fun for my guildies to enjoy.
What do you think?
Eventually I plan to do something similar with either Naxx full clear, or 2-3D Sarth (when we get there!).
Does anyone else want to share some WoW PvE videos?
Very cool Skyborn! I like!
Some great editing. Good vid, man. It's so rare to see nice videos without the UI showing. It really adds to the effect.
Not bad, not bad at all. Man I wish I had your FPS :<
"Yes." - Captain Obvious
What song is that?
The Tempest by Pendulum
Very cool. Much better than the crappy videos I make.
your hat may be nice, but I have the little white tank top that says Legendary right across my boobs. I win. (or more correctly, H wins)
**convinced it's a trap and it's actually porn, girlie doesn't watch**
haha wow---you have my favorite song in it. when i started the video i looked in windows media player to pause my play list and it was already paused and i got a lil creeped out.
its tempest - pendulum. i love how sarcastic it is.
cool vid but 1 thing..
It's Cider not Cinder =P
READ THIS: Posting & Chat Rules
nice video!
i wish i had the time to fool around with some video editing.


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Read genuine user reviews of Marks & Spencer from customers past and present. You can share your own experiences with others by submitting your own review at the bottom of the page.
|Marks & Spencer Summary
"Excellent service & competitive rate, very pleasant man who served me Friday evening 19/9 !! will always check M&S Merry Hill first."
"Brilliant service from friendly competent staff in Cribbs Causeway branch. All done briskly and efficiently followed by a cheery "Enjoy your trip". Aus dollars handed over in my choice of denominations. Thanks again M & S."
"Beware the rate advertised is only for M&S card holders. the rate drops considerably if you do not have an M&S card."
"M&S give a reasonable rate of exchange providing you have a credit card with them. Service is efficient and pleasant, though it is best to avoid luchtime queues if you are going into a branch to collect your money. A big bonus is that you can charge your M&S card without further costs and they are happy to give you denominations of your choice."
"What ca I say brilliant service from marksie in Torquay,great rate for on the street one of the best around and they had the curRency I wanted czch korona, really impressed defo going to be using them again"
"I have to say that the rates are not the best available but really fair considering the amazing, brilliant service. Always arrive very quickly by post and never any problems. Also when I have bought in store the staff are really well trained and switched on! All these reasons are why I keep going back to Marksies for travel money"
"I ordered my US$ on Friday at 12.30pm with Steph (extremely helpful) and she confirmed the note on the website that says currency ordered Friday (even before 2pm) may not arrive until Monday, but 7.15am Saturday morning there it was! Perfect service all round, I will most definately use again."
"Ordered my dollars with Barbara Measury, who was extremely helpful and polite, yesterday 11.15am and received them this morning 9.30. I always get my dollars from M&S, who give a good rate, NO extras to pay, and a great service. Thank you Barbara, M&S"
"A good rate and helpful staff who were happy to give me a fistful of low denomination notes (Hungarian forints]"
"Very competative rates and excellant service. Ordered my travel money and had it 2 days later"
"Always had excellent service and very competitive rates. Highly recommended."
"Very helpful and switched on staff. Best I've used and I travel a lot."
"As usual, working to the last minute before holiday and forgot to order holiday money! Checked the comparison sites and saw M&S had best rates for Mexican Pesos as not enough time to order cash online. Phoned M&S Taunton who confirmed they had Pesos (many do not hold them)and transaction was first class. They gave me the denominations i requested so would happily recommend M&S."
If you would like to share your own experiences of Marks & Spencer with other users, please use the form below. Please Aim to write at least a couple of sentences, and remember to be factual and honest with your opinions. If you are stuck for things to write about; tell us what the customer service was like, if you would buy from them again, and whether or not you would recommend their services to others. If you can include an order number this can help to prove you were a real customer should a supplier choose to reply. We reserve the right to remove malicious reviews or ones that we feel are fake or placed by companies to boost their profile.
Collect 5 free Maximiles points for submitting a review on Compare Holiday Money. Maximiles is an online loyalty programme that allows it's members to claim free rewards and discount vouchers in exchange for points collected by using certain websites. Click here for full details (opens a new window).
To claim your free points, simply use the email address associated with your Maximiles account, or create a free account.
Brand new to Compare Holiday Money - compare travel insurance quotes from over 30 top providers and buy your cover online.
FlyMy is dedicated to helping travellers, golfers, skiers - anyone with excess luggage to avoid some of the hassle of airline travel.
Compare airport parking prices for all the major UK airports and get a quote in minutes. Book online in advance and save money.
Back from holiday with some unwanted currency? Sell it back to an authorised dealer and get a better rate.
If you regularly send money abroad, check out this Regular Payment Plan and save hundreds of pounds a year.
Keep up to date with the latest news and analysis on the Compare Holiday Money Blog.
Save money on your next holiday abroad by following these 8 simple tips compiled by our resident currency experts.
We have teamed up with TheTrainLine.com bring you cheap and discounted train tickets.
All NEW Forums! Why not ask our community your travel money questions? The Compare Holiday Money Forum


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LEGO Batman: DC Super Heroes
Legends Unite! Batman and Robin join forces with other famous DC super heroes including Superman, Wonder Woman, Green Lantern and more to stop the notorious villains Lex Luthor and The Joker from destroying Gotham City. Batman fans everywhere will enjoy this original story that's filled with classic LEGO videogame action and humor as players fight to put the bad guys back behind bars!
This game includes many hours of content and cinematics that take up a lot of space! You will need 2.6 gb of available space on your device if you install over wifi, but only 1.3 gb of space if you download on your computer and then sync.
As with many large app installations, we advise that you restart your device after installing as this will resolve some stability issues. Also make sure you have installed the most recent firmware.
A few other things we are working on are more frequent saves in the game, and fixing stability issues that some of our players are experiencing.
Justice League favorites such as Superman, Wonder Woman, Green Lantern, and The Flash can be unlocked as you progress through the game or accessed at any time through purchase via our in-game store. Have Aquaman, Green Arrow, Cyborg and Hawkman help keep Harley Quinn, Poison Ivy, Penguin, and Catwoman in check!
Master abilities of suits such as Robin's Hazard Suit equipped with a Pressure Cannon, gadgets such as Batman's Batarang, and soar through the air with Superman as he fights crime with his Freeze-Breath and Heat Vision!
iPad Retina display compatibility takes LEGO games on the iOS platform to the next level.
Switch between "Classic" and "Touch Screen" controls to find the play-style that suits you best.
For the first time in a LEGO game for iOS, mini-figs talk and bring even more life to this original story!
Unlock achievements and connect through Game Center to get the full experience from your Gotham City adventure
What's new
Bug fixes and optimizations for iOS8.
Share with Others
- Last changed:
- Oct 10, 2014
- Category:
- Games
- Developer:
- Warner Bros.
- Version:
- 1.6
- Size:
- Current Version Average Rating:
- 4.00 (133)
- All Versions Average Rating:
- 4.00 (5966)
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• Heads Up!
• Hobbit Movies
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• Legend of the Guardians: The Owls of Ga'Hoole
• LEGO Harry Potter: Years 1-4
• LEGO Harry Potter: Years 5-7
• LEGO ® Marvel ™ Super Heroes: Universe in Peril
• LEGO® Friends
• LEGO® Legends of CHIMA: Speedorz™
• LEGO® Legends of CHIMA™ Online
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• Looney Tunes Scene & Sound Machine
• Looney Tunes Scene and Sound Machine Free
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• Man of Steel Experience
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• Monkey vs Chow HD
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• Tapper World Tour - FREE
• Tapper World Tour HD
• Tapper World Tour HD - FREE
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• Terminate Me
• Terminator: Salvation #1 FREE
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• Terminator: Salvation Graphic Novel
• The Hangover
• The Hangover Part II Photobooth
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• The Vampire Diaries
• The Vampire Diaries for iPad
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• Transcendence: Origins
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• WaterTower Music
• Wild Things


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Patients & Visitors
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Many nontraumatic situations or conditions may occur and need to be handled properly. Being prepared and knowing how to react ahead of time could prevent a situation from becoming an emergency. And learning how to respond to conditions and illnesses properly could make the difference between a potentially fatal outcome and a treatable, manageable situation.
Listed in the directory left you will find some additional information regarding preventing unintentional injuries, for which we have provided a brief overview.
If you cannot find the information in which you are interested, please visit the Nontraumatic Emergencies Online Resources page in this website for an Internet address that may contain additional information on that topic.
Preventing Unintentional Injuries Overview
Vital Signs (Body Temperature, Pulse Rate, Respiration Rate, Blood Pressure)
When to Call For Help
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Find an MUSC Doctor:
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text: Hi everyone, Has anyone ever heard of or knows of an English, French or Dutch pudding that includes a syrup made from vinegar? One of my friends is looking for the historical antecedents of the South African pudding recipe asynpoeding (vinegar pudding). It's similar to a self-saucing pudding, but is baked with a syrup spooned over it then served with custard. The vinegar is in the syrup not the pudding. I'm not a huge sweets person so I have no idea. ciao Lucrezia PS Thanks for all the afternoon tea suggestions - I will tell you how it goes! This electronic message contains information from CACI International Inc or subsidiary companies, which may be confidential, proprietary, privileged or otherwise protected from disclosure. The information is intended to be used solely by the recipient(s) named above. If you are not an intended recipient, be aware that any review, disclosure, copying, distribution or use of this transmission or its contents is prohibited. If you have received this transmission in error, please notify us immediately at postmaster at caci.co.uk Viruses: Although we have taken steps to ensure that this e-mail and attachments are free from any virus, we advise that in keeping with good computing practice the recipient should ensure they are actually virus free. CACI Limited. Registered in England & Wales. Registration No. 1649776. CACI House, Avonmore Road, London, W14 8TS.


text:
Dana Does it with "Glee": Ye Olde Lesbian Beer Garden (Ep. 4.20)
On this week's episode, Glee tackles sensitive issues. All of them. Meanwhile, Santana takes on the New York lesbian bar(re) scene.
International viewers can watch here.
Check back each week for Dana's latest Glee recap, and follow her on Twitter @DanaPiccoli.


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Nikon D3100 Digital SLR Camera Body + 18-55 VR Lens + 16GB + Accessories Bundle!
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Included in the Manufacturer Box:
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The Nikon D3100 Digital SLR Camera is an affordable, compact, and lightweight photographic power-house. It features the all-purpose 18-55mm VR lens, a high-resolution 14.2 MP CMOS sensor along with a feature set that's comprehensive yet easy to navigate - the intuitive onboard learn-as-you grow guide mode allows the photographer to understand what the 3100 can do quickly and easily. Capture beautiful pictures and amazing Full HD 1080p movies with sound and full-time autofocus. Easily capture the action other cameras miss with a fast start up time, split-second shutter release, 3 frames per second shooting and 11-point autofocus.
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MIAMI GARDENS — After the new coach said "errors" four times in the same breath, after the new No. 1 pick said "improve" three times in the same sentence, after the new Dolphins era started with the same thud the old one ended with, the new quarterback was asked where it hurt. He had been sacked four times, after all.
"Right here," Chad Pennington said, softly, following the Dolphins' 20-14 loss to the New York Jets.
He pointed to his chest.
"In my heart," he said.


text:
Best Holiday Fashion Gifts 2012
Shop Your Socks Off: Over 250 Great Gifts For Everyone on Your List!
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With only a week or so left to lock down your holiday shopping, we're helping you out by rounding up all of our amazing gift guide content. We've included everything — great gifts for your family members (even the picky ones!); your minimalist, bohemian, and girliest girlfriends; and even something for the special someone in your life — at all possible price points. Click through now to see and shop more than 250 perfect presents for everyone on your list!
Latest Fashion


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LEXINGTON, Ky. (Oct. 31, 2014) – Coldstream Park will host the city's fourth annual Free to Breathe fundraiser this Saturday, Nov 1. The inspirational event will feature a 5k run/walk and a 1-mile walk for all fitness levels, with awards for top fundraisers and finishers.
All proceeds from the event support Free to Breathe, a nonprofit lung cancer research and advocacy organization dedicated to ensuring surviving lung cancer is the expectation, not the exception.
Kentucky leads the nation in both new incidences of lung cancer and deaths from the disease. Though tobacco use is the biggest risk factor for developing lung cancer, anyone can develop the disease regardless of his or her smoking status. Lung cancer kills nearly twice as many women as breast cancer, and it is the leading cause of cancer deaths for both men and women in the U.S. Despite this, lung cancer receives proportionately less government funding per death than other types of cancer.
Free to Breathe aims to rally Kentuckians to create change and help defeat lung cancer. Supporters and participants are creating communities of hope by raising awareness of the disease and funds which can fuel advances in detection and treatment and ultimately save lives.
Registration for the event will begin at 8:30 a.m. Saturday, followed by the opening rally at 9:40 a.m. The cost to register that day is $30. Registrants can choose to participant in one of three events:
· 5K Run, beginning at 10 a.m.
· 5K walk, beginning at 10:05 a.m.
· 1-mile walk, beginning at 10:10 a.m.
For more information on Free to Breathe, visit www.freetobreathe.org.
LEXINGTON, Ky. (Oct. 29, 2014) – The University of Kentucky Markey Cancer Center has
signed a memorandum of cooperation to collaboratively study lung cancer with the Nanjing
Medical University in the Jiangsu Province, China.
Earlier this month, Dr. Mark Evers, director of the UK Markey Cancer Center, and Daret St. Clair, associate director for basic research, visited Nanjing Medical University to sign the memorandum with Nanjing Medical University Chancellor Shen Hongbin agreeing to collaborate on future projects in cancer research.
The initial contact between the two institutions developed with the exchange of researchers and clinicians between St. Clair's laboratory and Nanjing Medical University Affiliate Hospital, the first Nanjing Hospital. Markey's strength in basic research was a collaborative match with Nanjing Medical University investigators who have specific expertise in the genetic and epigenetic analyses of lung cancers.
Kentucky has the highest mortality rate of lung cancer in the U.S., but lung cancer is also a common disease in China.
"Cancer is a global problem," Evers said. "This partnership with Nanjing Medical University will establish collaborative ties with their talented investigators as we work together to fight cancers that have a high incidence in both Kentucky and China."
In addition, there may be opportunities to share clinical trial expertise between the two institutions.
"This is an excellent example of how the Markey Cancer Center continues to expand its network and reach, not only regionally but globally as well," Evers said.
LEXINGTON, Ky. (Oct. 23, 2014) – The University of Kentucky Markey Cancer Center's Jin Shin Jyutsu practitioner Jennifer Bradley will be the featured guest on SiriusXM Family Talk Channel 131's "Aches and Gains" with Dr. Paul Christo the next two Saturdays.
Originally scheduled for just one show, Bradley's interview was expanded to two. The first airs Saturday, Oct. 25 at 5 p.m., with the second installment airing Saturday, Nov. 1 at 5 p.m. Podcasts are accessible after the show at www.paulchristo.com.
Jin Shin Jyutsu (JSJ) is an ancient form of touch therapy similar to acupuncture in philosophy. Bradley, a licensed practitioner, originally began offering free JSJ sessions to patients as a Markey volunteer in 2009. In 2010, she received a $49,000 initial grant from the Lexington Cancer Foundation to provide the touch therapy to cancer patients full-time. Since then, Bradley has offered up to five free sessions to Markey patients at no charge.
JSJ is considered part of an integrative treatment plan at the UK Markey Cancer Center. Patients may self-refer, though many patients currently seen are referred by their physician or Markey staff.
During a session, patients receive light touches on 52 specific energetic points called Safety Energy Locks as well as fingers, toes, and midpoints on the upper arm, upper calf and lower leg in predetermined orders known as "flows." Patients remained clothed except for shoes and all hand placements are done over clothing.
LEXINGTON, Ky. (Oct. 22, 2014) – In 1994, University of Kentucky alumna Cathy Bell was diagnosed with breast cancer – for the first time.
Because she had a family history of the disease (her grandmother fought breast cancer), she began having mammograms at an earlier age than most. And during her baseline mammogram at age 39, her doctors discovered an unusual pattern of calcifications, and ultimately, a malignancy.
Treatment quickly followed – a lumpectomy (a breast-conserving surgery) and radiation. Bell, then a busy elementary school principal, says she was mainly concerned about getting back to work.
"I had a school to run and needed to get past that 'bump in the road' and return to my duties," she said.
Ultimately, Bell only missed four days of school. She headed back to work as soon as she could, fitting in an hour of daily radiation into her schedule. When her treatment was completed, she thought she was done.
"I thought I had moved past it," she said.
Local recurrence, or the return of a cancer to its original location, is a relatively uncommon circumstance. Most of the time, a local recurrence will happen within the first five years following diagnosis.
However, in a few instances, a local recurrence can happen many years down the road. In Bell's case, she was nearly two decades cancer-free before receiving that sobering diagnosis for a second time.
In 2013, she noticed an unusual pain under her arm. Though she'd had a regular mammogram only six months earlier, she went back to her doctor for another. The results showed a similar pattern of unusual calcifications in the same breast – her cancer had returned.
Now retired, Bell says she spent a great deal of time researching treatment for breast cancer, and her investigations led her to University of Markey Cancer Center breast surgical oncologist Dr. Patrick McGrath. Because she'd undergone radiation therapy previously, Bell could not use that treatment again, which is commonly paired with a lumpectomy.
Instead, she opted for a bilateral mastectomy with delayed reconstructive surgery. Additionally, she underwent genetic counseling at Markey to determine if she carried the BRCA1 or BRCA2 gene mutation – a test she did on behalf her sisters, who are now considered "high risk" due to having two close family members with breast cancer. Luckily, Bell's results were negative.
Bell, an avid writer, says she turned to poetry to help work through her emotions after her second diagnosis. Shortly before her surgery, she composed a piece titled "This One is About Me." The poem, written in a catchy cadence with humor sprinkled throughout, served another purpose – to give her friends and family information on her health straight from the source and help them understand what she was going through.
"I turned to creativity to deal with my issues," she said. "That's how I dealt with all that information."
Shortly after she wrote her poem, Bell received a letter from the UK Markey Cancer Center inviting her to participate in the center's inaugural "Expressions of Courage" event, a creative exhibit showcasing original artistic expressions created by cancer patients, friends and family. Bell immediately knew she wanted to participate.
"I thought, wow, I already have this done!" she said.
Contributing to Expressions of Courage was just one way Bell has given back. She notes that she "loves UK" and supports the Markey Cancer Foundation and other cancer research organizations when she can. And having gone through the difficulties of dealing with breast cancer not once, but twice, she says her role now is to help others deal with their own diagnoses and to help in any way she can, noting that sometimes that just means lending an ear. She is frequently called up by friends or family members affected by breast cancer, who are seeking help and understanding for themselves or on behalf of a loved one.
"This is just the way it's supposed to be," Bell said. "I feel like I'm here to help other people… Famous people may write a book or talk publicly, but that's not my style. I'm a good listener when I need to be."
Earlier this year, Bell was dealt another small setback when she was diagnosed with squamous cell carcinoma in her lip. After undergoing Mohs surgery, the former UK cheerleader was back to living her life yet again, staying busy in retirement – and remaining eternally optimistic.
"It's just what I've been dealt," she says. "I love life and I want to keep living it!"
MEDIA CONTACT: Allison Perry, (859) 323-2399 or firstname.lastname@example.com
LEXINGTON, Ky. (Sept. 19, 2014) – Kentucky faces some of the highest rates of cancer incidence and mortality in the nation, but Methodist Hospital in Western Kentucky is stepping up the fight against cancer. The Methodist Hospital organization in Henderson, Ky., has announced a new affiliation with the University of Kentucky Markey Cancer Center, the state's first and only National Cancer Institute-designated cancer center.
Methodist Hospital CEO Bruce Begley said the announcement meant great things for their patients.
"The Methodist Hospital affiliation with the UK Markey Cancer Center brings to this region nationally ranked cancer treatment close to home," Begley said. "We believe this is a big step in the continuing battle against cancer, and I appreciate UK HealthCare's overall mission of extending high-quality cancer care to all Kentuckians."
"We are extremely excited and proud for our cancer care program to become an affiliate of the Markey Cancer Center," said Dr. Arshad Husain, medical director of hematology and oncology at Methodist Hospital. "This alliance means great things for our patients. It will enable us to offer access to the latest practices in diagnosis and treatment of cancers and blood disorders, including clinical trials – thus providing a higher level of cancer care in our neighborhood."
The UK Markey Cancer Center Affiliate Network was created to provide high-quality cancer care closer to home for patients across the region, and to minimize the effects of cancer through prevention and education programs, exceptional clinical care, and access to research.
Methodist Hospital in Henderson is a 192-bed acute care facility and is just one facet of the Methodist Hospital Healthcare system. Other facilities serving the area include
Methodist Hospital Union County, a critical access hospital in nearby Morganfield, Ky., and 19 outpatient physician offices with 47 providers over a four-county service area.
By becoming a UK Markey Cancer Center Affiliate, Methodist Hospital is in keeping with the organization's mission to provide safe, compassionate, high quality, and cost-effective services to the communities served. The Methodist Hospital Healthcare system will now be able to offer their patients access to additional specialty and subspecialty physicians and care, including clinical trials and advanced technology, while allowing them to stay in western Kentucky for most treatments.
The Markey Cancer Center Affiliate Network supports UK HealthCare's overall mission of ensuring no Kentuckian will have to leave the state to get access to top-of-the-line health care.
"UK HealthCare doesn't just serve Lexington and central Kentucky – our mission is to provide all Kentuckians with the best possible care right here in the state," said Dr. Michael Karpf, UK executive vice president for health affairs. "The Markey Cancer Center Affiliate Network allows us to collaborate with community hospitals to provide top-notch cancer care much closer to home -- saving both travel expenses and time for the patients, in addition to keeping them close to their personal support system."
Markey is one of only 68 medical centers in the country to earn an NCI cancer center designation. Because of the designation, Markey patients have access to new drugs, treatment options and clinical trials offered only at NCI centers.
Moving forward, the Markey Cancer Center is working toward the next tier of designation – an NCI-designated Comprehensive Cancer Center. Currently, 41 of the 68 NCI-designated cancer centers in the country hold a comprehensive cancer center status. The Markey Cancer Center Affiliate Network will play a large role in bringing that next level of cancer funding to Kentucky.
"The burden of cancer in Kentucky is huge, and unfortunately we have some of the worst cancer rates in the country," said Dr. Mark Evers, director of the UK Markey Cancer Center. "By collaborating with our affiliate hospitals across the state, we have the potential to make a serious impact on cancer care here in the Commonwealth."
The UK Markey Cancer Center Affiliate Network began in 2006 and comprises 12 hospitals across the state of Kentucky:
Evaluations are under way for several other hospitals, including two more outside the state of Kentucky, extending Markey's reach and establishing it as the destination cancer center for the region.
LEXINGTON, Ky. (Sept. 18, 2014) - To celebrate Ovarian Cancer Awareness Month, cancer survivors and UK faculty and staff participated in a special tailgating event called "tealgating" eariler this month.
The event further helped create awareness about the UK Ovarian Screening Program, an ongoing study that uses transvaginal ultrasound to detect ovarian cancers. Women over age 50 and women over age 25 who have a family history of ovarian cancer are eligible for the free program.
More than 43,000 women have participated in the UK Ovarian Screening Program and more than 256,000 free ultrasound screens have been done through the program. Women from every county in Kentucky have participated in the program ane more than 85 malignancies have been detected.
For more information on the program or to schedule an appointment, visit http://ovarianscreening.info.
LEXINGTON, Ky. (Sept. 16, 2014) – Dr. Edward M. Wolin, a nationally known expert in treating neuroendocrine and carcinoid tumors, has joined the team at the University of Kentucky Markey Cancer Center.
Neuroendocrine tumors develop from endocrine cells found in the digestive tract, lungs, pancreas, and other sites. These rare cancers present unique diagnostic challenges. They tend to be slow-growing, and usually have metastatic disease at the time of diagnosis.
At Markey, Wolin will serve as the director of the Carcinoid and Neuroendocrine Tumor Program. In addition to working with Markey's team of surgical and radiation oncologists, pathologists, and diagnostic radiologists, Wolin will collaborate on patient care with UK Chief of Medical Oncology Dr. Lowell Anthony. Anthony came to UK in 2011 and helped build up Markey's Neuroendocrine Clinic, the region's first multidisciplinary clinic dedicated to endocrine and neuroendocrine tumors.
Wolin brings a robust research program to Markey, including multiple clinical trials. His research efforts focus on finding treatments which are more effective and less toxic, including pasireotide, lanreotide, everolimus, other m-tor inhibitors, targeted radiation including peptide receptor radiotherapy with Lu-177, anti-angiogenic drugs, novel targeted biologic anti-cancer treatments, and targeted treatment of liver metastases. Wolin's research is also directed at development of new imaging and diagnostic procedures for carcinoid/neuroendocrine tumors.
"Dr. Wolin is renowned for his skill in treating these complex forms of cancer, and we are thrilled to bring his expertise to our patients here in Kentucky," said Dr. Mark Evers, director of the UK Markey Cancer Center. "Through his clinical trials, many patients will be able to receive extremely specialized care that they couldn't get anywhere else in the country."
Wolin earned his medical degree at Yale University School of Medicine. He performed his internship, residency and a medical oncology fellowship at Stanford University Medical Center followed by a clinical fellowship at the National Cancer Institute in Bethesda, Maryland. Prior to coming to Markey, he served as co-director of the Cedars-Sinai Carcinoid and Neuroendocrine Tumor Program at Cedars-Sinai Medical Center in Los Angeles.
Wolin sees patients in the Multidisciplinary Clinic on the first floor of the UK Markey Cancer Center's Whitney-Hendrickson building. To make an appointment, call 859-257-4488 or toll free 866-340-4488.
LEXINGTON, Ky. (Sept. 15, 2014) – A new study by University of Kentucky researchers has identified a novel molecule named Arylquin 1 as a potent inducer of Par-4 secretion from normal cells. Par-4 is a protein that acts as a tumor suppressor, killing cancer cells while leaving normal cells unharmed.
Normal cells secrete small amounts of Par-4 on their own, but this amount is not enough to kill cancer cells. Notably, if Par-4 secretion is suppressed, this leads to tumor growth.
Published in "Nature Chemical Biology," the UK study utilized lab cultures and animal models to show that low levels of Arylquin 1 induced Par-4 secretion without causing harm to the producer cells.
Additionally, researchers found that Par-4 is bound to a protein called vimentin, which contributes to tumor metastasis. Arylquin 1 binds to vimentin, displacing the Par-4 for secretion -- which means it may also be useful for inhibiting the spread of cancer.
These findings have strong implications for the development of future cancer treatments, as researchers are now focusing on developing Arylquin 1 into a drug to inhibit both primary and metastatic tumors.
"We found that Par-4 is inactivated by pro-metastasis proteins such as vimentin," said Vivek Rangnekar, UK professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine. "This implies that by using small molecule drugs that target metastasis proteins, we may be able to both inhibit the spread of cancer while also releasing the tumor suppressor -- Par-4 -- to then induce the death of the cancerous cells."
Rangnekar, who also serves as associate director for the UK Markey Cancer Center, initially discovered the Par-4 gene in 1994. Working closely with UK medicinal chemist David Watt and a multidisciplinary team across the UK campus, their labs are developing secretagogues that can cause elevated secretion of Par-4 for the inhibition of primary and metastatic tumors.
This study was funded by grants from the National Cancer Institute, the National Center for Research Resources, and the UK Center for Clinical and Translational Science.
LEXINGTON, Ky. (Sept. 15, 2014) -- Did you know that you can help others by participating in research? Health-focused research affects every aspect of our lives, from the medications we take to the health of our environment. Researchers are working hard to identify new treatments and strategies to improve the health of our communities, but research needs healthy volunteers and volunteers with medical conditions in order to succeed. Participating in research is a safe, easy way for you to give back to your community and give hope for the future while learning more about your own health.
Find out how you can participate in research during the University of Kentucky's next #AskACat Twitter chat, beginning 2 p.m. Tuesday, Sept. 16, at @universityofky. UK researchers will answer general questions about participating in research. They will also answer questions about ResearchMatch, a registry that pairs volunteers with researchers looking for participants, and UK's new Research Registry and Specimen Bank, or the "biobank." For more information on ResearchMatch, visit www.researchmatch.org/?rm=@AskaCat.
UK patients are being invited to help researchers by allowing leftover blood and tissue from their normal medical procedures to put into the biobank. For example, when a patient undergoes a blood draw or tissue biopsy, the blood or tissue that isn't used for testing is normally thrown away. In the new biobank project, however, patients will be given a consent form to allow any "leftover" blood or tissue from their regular medical procedures to be stored in the biobank for research purposes. No additional procedures will be performed or extra blood or tissues collected whatsoever. Participation is voluntary, and to protect patient privacy, all identifying information (such as name, address and social security numbers) will be removed from the samples and corresponding medical records.
Four UK experts will respond to questions during the chat:
· Belinda Smith, education specialist at the Office of Research Integrity;
· Ada Sue Selwitz, director of the Office of Research Integrity;
· Dr. Susanne Arnold, associate professor in medical oncology and radiation medicine and associate director for clinical translation at the Markey Cancer Center; and
· Dr. Phil Kern, director of the Center for Clinical and Translational Science and the Barnstable Brown Diabetes and Obesity Center.
Join the conversation or follow the chat at the university's official account @universityofky, or use the hashtag #AskACat for questions and responses from the Twitter chat.
Individuals interested in asking questions about participation in health care research, ResearchMatch, or the biobank can send their questions to twitter.com/universityofky through 3 p.m. Sept. 16, or to the UK Facebook page prior to 2 p.m., Sept. 16. Responses to questions will be shared with the university's Twitter followers and those following the hashtag #AskACat.
UK will present its next #AskACat Twitter chat Oct. 21.
MEDIA CONTACT: Whitney Hale or Elizabeth Adams, 859-257-1754
LEXINGTON, Ky. (Sept. 3, 2014) – Hardin Memorial Health celebrated a new affiliation between its Cancer Care Center and the University of Kentucky Markey Cancer Center, the state's first and only National Cancer Institute-designated cancer center.
"The Markey affiliate agreement provides a great opportunity for professional education and training for our staff and physicians," said Hardin Memorial Health President Dennis Johnson. "Collaboration with Markey and their affiliates across the state allows our team to stay up-to-date on the newest cancer treatments and research."
"There is no reason for cancer patients in central Kentucky to leave this area to seek treatment, because the HMH Cancer Care Center provides personalized cancer care close to home," said Dr. Adam Lye, medical director of the Hardin Memorial Health Cancer Care Center. "This care can be enhanced when combined with Markey's specialized treatment, technology and clinical trial opportunities that will help us take cancer care to the next level. This is great news for cancer patients and their families in our community."
By joining the UK Markey Cancer Center Affiliate Network, the HMH Cancer Care Center will be able to offer their patients access to additional specialty and subspecialty physicians and care, including clinical trials and advanced technology, while allowing them to stay closer to home for most treatments. The Markey Cancer Center Affiliate Network supports UK HealthCare's overall mission of ensuring no Kentuckian will have to leave the state to get access to top-of-the-line health care.
The UK Markey Cancer Center Affiliate Network began in 2006 and comprises eleven hospitals across the state of Kentucky:
LEXINGTON, Ky. (Aug. 19, 2014) – A new web-based program developed by University of Kentucky Markey Cancer Center researchers will provide a simple, free way for healthcare providers to determine which brain tumor cases require testing for a genetic mutation.
Gliomas – a type of tumor that begins in the brain or spine – are the most common and deadly form of brain cancer in adults, making up about 80 percent of malignant brain cancer cases. In some of these cases, patients have a mutation in a specific gene, known as an IDH1 mutation – and patients who have this tend to survive years longer than those who do not carry the mutation.
Developed by UK researchers Li Chen, Eric Durbin, and Craig Horbinski in collaboration with software architect Isaac Hands of the UK Markey Cancer Center Cancer Research Informatics Shared Research Facility, the program uses a statistical model to accurately predict the likelihood that a patient carries the IDH1 mutation and requires screening.
Gliomas are often tested for IDH1 mutation following surgery to remove the tumor, but undergoing this type of testing often requires stringent insurance pre-approvals due to rising healthcare costs, Horbinski says.
"Currently, there are no universally accepted guidelines for when gliomas should be tested for this mutation," Horbinski said. "Obtaining insurance pre-approval for additional molecular testing is becoming more commonplace, and this program will assist healthcare providers with an evidence-based rationale for when IDH1 screening is necessary."
Additionally, Horbinski notes that the program will help conserve research dollars by helping brain cancer researchers narrow down which specific older gliomas in tumor banks – previously removed in a time before IDH1 testing was routine – should be tested as data for research projects.
Horbinski's research on the program was published in the May issue of Neuro-Oncology. The work was funded through a grant from the National Cancer Institute, the Peter and Carmen Lucia Buck Training Program in Translational Clinical Oncology, and the University of Kentucky College of Medicine Physician Scientist Program.
LEXINGTON, Ky. (Aug. 13, 2014) – Becker's Hospital Review magazine has listed the University of Kentucky Albert B. Chandler Hospital among the nation's "100 Hospitals and Health Systems with Great Oncology Programs" in its recently released compilation of leading cancer care providers in the United States. The UK Markey Cancer Center, whose clinical programs are integrated with Chandler, received a National Cancer Institute cancer center designation in July 2013.
According to the health care industry trade publication, organizations included on the 2014 list are "leading the way in terms of quality of patient care, patient outcomes and research." Becker's noted Markey's recent NCI designation, its 29 percent patient growth over the past five years, and its status as a Blue Distinction Center for Complex and Rare Cancers for 10 cancer types.
The Becker's Hospital Review editorial team selected hospitals for inclusion based on rankings and awards they have received from a variety of reputable sources. The following awards were considered as part of the criteria for inclusion on the list: U.S. News & World Report cancer rankings, Truven Health Analytics, CareChex cancer care rankings, National Cancer Institute designations, the American College of Surgeons Commission on Cancer accreditations, American Nurses Credentialing Center designations, and awards and Blue Distinction Center recognition from the BlueCross BlueShield Association.
LEXINGTON, Ky. (July 30, 2014) – As part of a weeklong tour across the state, the Smoke-Free Kentucky Coalition will be making a stop at the University of Kentucky Markey Cancer Center today at 11 a.m. to promote better health for Kentuckians through smoke-free policies. The event at Markey is one of several stops across the state as it heads to western Kentucky for the annual Fancy Farm Picnic.
At each stop, the Smoke-Free Coalition is rallying supporters and reaching out to legislators, urging them to join 24 other states in passing a comprehensive, statewide smoke-free law that covers all indoor workplaces and public places, including bars and restaurants. The goal of the tour is to get all Kentuckians, around the state, active and engaged in supporting smoke-free policy as the campaign gears up for the 2015 legislative session.
Secondhand smoke contains more than 7,000 chemicals, almost 70 of which are known to cause cancer, and is proven to cause heart disease, lung cancer, respiratory illnesses and even premature death. In fact, studies indicate that secondhand smoke exposure causes about 1,000 deaths a year in Kentucky.
To find out more information about how smoke-free policies are good for health and businesses visit: www.smokefreekentucky.org
LEXINGTON, Ky. (July 30, 2014) — The phrase "we caught it early" is possibly the best news a patient can hear in the midst of a cancer diagnosis. Combating cancer in its earliest stages, when the disease is localized to a certain part of the body, gives patients the best chances of survival.
Screenings for breast, skin, colon, prostate and other forms of cancer are touted for saving lives through early detection. Many health care providers recommend cancer screenings as a precautionary measure, especially for high-risk patients. But in the case of lung cancer, the leading cause of cancer death in the United States, the patient's decision to undergo a screening process is more complex.
According to University of Kentucky psychologist Dr. Jamie Studts, lung cancer screening is an algorithm, not an event. Patients aren't always aware of the physical and psychological consequences of the lung cancer screening process, which can lead to false positive results, invasive biopsy procedures, harmful radiation exposure and anxiety caused by an ongoing process.
Studts, a researcher in the UK Department of Behavioral Science and the Cancer Prevention and Control Program of the Markey Cancer Center, is working to develop an online tool that will help individuals at high risk for lung cancer navigate the lung cancer screening decision-making process. He said the decision to undergo lung cancer screening should be well-informed and aligned with the patient's personal values. Studts is collaborating with Dr. Margaret Byrne, a health economist and medical decision-making researcher at the University of Miami, on this project, which is funded by a grant awarded from the National Cancer Institute.
"Screening is for asymptomatic, healthy people to find out there's something wrong," Studts said. "You are committing to a series of events that will lead to either learning you don't have cancer, or detecting and treating it."
A number of factors, including the Affordable Care Act's provision of accessibility to cancer screening services and results from a 2011 National Lung Screening Trial conducted by the National Cancer Institute, have reinvigorated the public's interest in lung cancer screening. The National Lung Screening Trial reported a 20 percent relative reduction in mortality for high-risk individuals who received a low-dose computed tomography (CT) scans. But the report also identified substantial risks and limitations to lung cancer screenings, which included overdiagnosis and relatively high false positive rates. The rate of false positive occurrence in the study of a high-risk population was 39 percent. With high rates of false positive scans and ongoing follow-up treatment, Studts said widespread lung cancer screening could be a costly burden for government-funded health care but could also prevent very expensive treatments for late stage lung cancer.
Studts and his fellow researchers have proposed a decision-making aid that is designed to accomplish three objectives: disperse knowledge, empower the patient and clarify individual's values. The aid will present accurate information about the screening process and calculate feedback that's tailored to the individual. The tool will also empower the individual to discuss the decision with their health care provider by providing a prompt list of potential questions. Finally, the values clarification component of the tool will explore the patient's personal preferences regarding the lung cancer screening process. For instance, if a patient is ultimately unwilling to undergo surgery for a lung biopsy, the tool can determine that they will likely experience minimal benefit from a screening.
"The goal is to help people interpret what they learn in the context of what's important to them regarding their goals in health," Studts said. "They will learn about lung cancer screening options, benefits, harms and uncertainties associated with the modality."
To develop the provider education program, Studts has collaborated with a team of University of Kentucky experts, including Dr. Eric Bendsadoun, a pulmonologist and director of the lung cancer screening program; Dr. Susanne Arnold, a medical oncologist who is part of the multidisciplinary lung cancer screening program; Dr. Michael Brooks, a cardiothoracic radiologist; Dr. Mark Dignan, a cancer prevention and control researcher; Dr. Eric Durbin, a cancer research informatics expert; and Dr. Brent Shelton, a cancer biostatistician.
The next step in their research will be conducting a clinical trial to test the decision-making aid among high-risk individuals, or high pack-year smokers, in Florida and Kentucky. Recently, Studts, along with Dr. Tim Mullet, a cardiothoracic surgeon at UK, received funding from the Kentucky Lung Cancer Research Program to develop an online continuing education program geared toward educating health care providers about lung cancer screening and how to discuss the lung cancer screening question with their patients. Eventually, he envisions dispersing a comprehensive educational toolkit on lung cancer screening to clinics and hospitals.
Studts said the current research suggests that lung cancer screening has minimal benefits for individuals younger than 55. Still, many Americans with a history of high pack-year smoking will face the decision of whether to be screened for cancer in their lifetime. Studts believes it will be helpful to implement an online tool that will help guide members of the high-risk population through a decision-making process.
"We're interested in delivering high quality patient centered care – helping people be engaged in their health care choices and helping health care providers engage in these choices too."
MEDIA CONTACT: Elizabeth Adams, email@example.com
LEXINGTON, Ky. (Aug. 6, 2014) – The Louisville Ironman – a triathlon consisting of a 2.4-mile swim in the Ohio River, a 112-mile bike ride, and a 26.2-mile run – is a competition that would test even the toughest of wills.
But for University of Kentucky radiation oncologist Dr. Jonathan Feddock, the competition is about more than achieving a personal goal – Feddock, an accomplished triathlete, is using his athletic talents to help provide better care for the cancer patients he treats. When he competes in the Aug. 24 Ironman, he'll be doing so to raise money to pay for renovations and updates to the brachytherapy program at the UK Markey Cancer Center.
Brachytherapy is a specific form of radiation treatment where radiation sources are placed inside or close to the area requiring treatment.
"The main benefit to using brachytherapy for the treatment of cancer is that this is the only method of radiation treatment where we can make radiation appear exactly where we want to," said Feddock. "If your goal is to treat a tumor with curative doses of radiation and not treat the normal parts of the body immediately next to it, then brachytherapy is the best option."
The total estimated cost for the brachytherapy project is approximately $1.2 million dollars, and Feddock has a specific goal to reach – he is trying to raise $200,000, with the remaining $1 million to be matched through the University, independent philanthropists, and department funds. The proposed changes would consolidate all areas involving brachytherapy, including moving the implant procedure room and the radiation treatment room into a combined space, and upgrading the current brachytherapy equipment.
Brachytherapy treatment is commonly used to treat most gynecologic cancers, as well as malignancies of the breast, prostate, and skin. Under Feddock's leadership, the radiation medicine department has developed a niche practice that uses brachytherapy for recurrent tumors in patients who have previously received radiation. As a result, UK sees patients from all over the country.
Unfortunately, Kentucky holds the distinction of having some of the highest cancer rates in the country – including being No. 8 in the U.S. for cervical cancer incidence. The availability of brachytherapy in the state is limited, and as a result, Markey provides brachytherapy services for essentially all patients coming from central, eastern and southern Kentucky.
Currently, Markey patients receive their brachytherapy implants in the Ben F. Roach Building, but have to be transported down a long hallway to the radiation treatment room in the UK Albert B. Chandler Hospital. Because the radiation therapy treatment and recovery rooms require a shielded vault, consolidation is not an easy process.
However, Feddock points out, the renovations will improve staff efficiency and the overall patient experience, in addition to allowing his team to see even more patients per day.
"Currently, the setup and logistics of brachytherapy treatment limit me to no more than two cases a day," Feddock said. "As our patient population grows, there's a real need to streamline the process so we can see more patients. I believe the proposed changes would allow me to treat three to four patients a day."
Feddock is determined to reach his goal, and he's even implemented a clever strategy to bring in donations. After speaking with members of the World Triathlon Corporation, he has been given special permission to begin the Ironman in Louisville this year in last place – and he's encouraging donors to "bet against him" by pledging a small amount for every single person he passes in the race. With close to 3,000 competitors ahead of him, that's a lot of potential donations.
The plan becomes more impressive when you look at his track record: in 2011, Feddock finished 30th in the Ironman; in 2013, he finished 17th.
"While I'm approaching some corporate sponsors and individual philanthropists about making larger donations, I think crowdfunding is the key here," Feddock said. "Every single dollar helps, and if a lot of different people contribute just a small amount, it will add up. By pledging even a small donation, you'll be making a huge impact on cancer care for women and men across Kentucky."
Dr. Marcus Randall, chair of the Department of Radiation Medicine, says his team fully supports Feddock's undertaking.
"Dr. Feddock's commitment to his patients and to UK HealthCare is inspirational to us all," Randall said. "The department is strongly supporting Dr. Feddock, which shows that we truly have 'skin in the game' when it comes to giving our patients the best treatment possible."
To support Feddock's mission and improve patient care at the UK Markey Cancer Center, visit his personal fundraising page, Ironcology.net for details on how to donate. All donations are processed through the Markey Cancer Foundation.
The Comprehensive Breast Care Center Receives Prestigious Accreditation The Comprehensive Breast Care Center at the UK Markey Cancer Center has undergone a transformation over the past year and a half. The CBCC performs a full range of services, including
Clinical trials offer tailored, inventive cancer treatments by Allison Perry LEXINGTON, Ky. (Feb. 21, 2012) The following column appeared in the Lexington Herald Leader on Sunday, Feb. 19, by Dr. Jay HayslipToday's cancer therapies are far different than the treatments
'Colon cancer is a silent killer' Survivor Anna Arthur talks about the importance of screenings In our culture, many women shy away from telling others how old they are. As a 14 year survivor of colon cancer, Lexington resident Anna
Markey Announces High Survival Rates for Many Cancers LEXINGTON, Ky. (Sept. 6, 2011) — New data officially released today shows University of Kentucky Markey Cancer Center patients who have certain types of cancer have higher survival rates than patients with
Markey patient named LLS "Man of the Year" »
Homemade "survival bracelets" honor late UK coach, raise money for cancer research »
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Approvals, disapprovals, or other decisions made under these rules may be appealed by an applicant as follows:
(A) The aggrieved party may request in writing that an informal meeting be held with the deputy director, the chief, a representative of the board, and the applicant to discuss and attempt to resolve the particular problem through negotiation and settlement. Such request shall include a written summary of the controversy. The chief shall schedule said meeting and shall give all parties reasonable notice thereof in writing. At the conclusion of such meeting, a report documenting the problem, the efforts made at the meeting to resolve the problem, and any resolution reached shall be submitted by the chief to the director for his/her consideration and approval. If the director requires additional data or documentation from the aggrieved party relative to the issue(s) or problem(s) in question in order to adequately evaluate the resolution reached, such data or documentation shall promptly be provided by said party.
(B) In the event informal meetings requested do not result in resolution of the controversy, or if no informal meetings are desired by the aggrieved party, said party may request by certified mail that a formal hearing be convened pursuant to section 119.06 of the Revised Code, as hereafter may be amended, with the director or a designee presiding, to hear the controversy and make a formal decision thereon. Appeals from such formal hearing shall be made as provided by section 119.12 of the Revised Code, as may hereafter be amended.
Effective: 07/01/2009
R.C. 119.032 review dates: 04/14/2009 and 07/01/2014
Promulgated Under: 119.03
Statutory Authority: 5119.61 to 5119.63
Rule Amplifies: 5119.61 to 5119.63
Prior Effective Dates: 5-29-1971, 8-21-1980


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EDINBURG, TEXAS ---- The Rio Grande Valley WhiteWings scored four runs late in the game to defeat the Edinburg Roadrunners 7-4 at the Edinburg Baseball Stadium Friday night. With the loss the Roadrunners fall a game behind the WhiteWings for fourth in the United League Standings.
The Roadrunners got on the board in the top of the first inning on an RBI groundout by Carlos Hereaud that scored Wilmer Pino from third base for an early 1-0 lead.
Rio Grande Valley tied the game in the top of the third inning on an RBI triple by Agustin Septimo that scored Casey Allen. Denys Lantigua then singled to right center field to allow Septimo to score from third giving the WhiteWings a 2-1 lead.
Edinburg tied the game in the bottom of the fourth after Bryon Smith walked to lead off and then moved to third after a few wild pitches by starting Sendy Vasquez. Vincent Blue followed with a walk and took second, while Smith scored on the overthrow to second by WhiteWings catcher Sandy De Leon to make it a 2-2 game.
RGV took the lead once again in the top of the sixth inning on an RBI fielder's choice from Rico Santana that scored Septimo from third making it 3-2 in favor of the WhiteWings.
In the bottom of the seventh inning Osiel Flores led the inning off with a walk then moved to second on a sacrifice bunt by B.J. Wheeler and moved to third where after lack of coverage on third base. Pino hit an RBI ground out to third base that allowed Flores to touch home plate. Robert Matlock then singled to center and later came in to score on an RBI single by Smith which gave the Roadrunners a 4-3 lead.
The WhiteWings responded in the top of the eighth inning with two runs against starter Tim Haines (4-4) and then added two more runs in the top of the ninth inning against Aaron Guerra who came in to relieve Haines in the eighth.
Julio Santana pitched a scoreless ninth for his 12th save of the season.
The Roadrunners and WhiteWings will play the third game of this four-game series on Saturday night at the Edinburg Baseball Stadium. Miguel Martinez (3-2) is expected to face Juan Peralta (0-2) with the first pitch at 7:05 p.m.


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The new version 2.31 with Windows 8.1 support is available now.
The IEEE 1394 High Performance Serial Bus (also known as FireWire or i.Link™) is supported by all current Windows operating systems. Windows provides a bus driver and device drivers for various IEEE1394 OHCI compliant host controllers (e.g. from Texas Instruments / TI, VIA, RICOH or NEC). The Windows 1394 driver stack exports a programming interface which is available in kernel mode only. Win32 applications running in user mode are not able to access this interface.
It is for this reason that communication between Windows applications and IEEE 1394 devices requires a kernel-mode driver which has to conform to the Windows Driver Model (WDM).
Developing a kernel-mode WDM driver is considerably different to developing Windows applications. It requires specialist knowledge in kernel-mode programming and a deep understanding of operating system internals. The development and debugging process can be very time-consuming, especially if the driver has to support different Windows systems. These driver development efforts can avoided using the generic IEEE 1394 device driver VHPD1394.
The generic high performance IEEE 1394 device driver, VHPD1394, provides Win32 applications with direct access to IEEE 1394 devices. It can be used with any kind of IEEE 1394 device, enabling application developers to control devices without having to develop a kernel-mode WDM driver. The VHPD1394 driver provides an extensive programming interface based on standard Windows API functions. It supports complete IEEE 1394 functionality and is optimized for maximum efficiency.
Programming Interface
The Win32 native VHPD1394 programming interface is ideal for use in programming languages such as C and C. The VHPD1394 toolkit includes a C++ class library, providing an easy-to-use interface. There are numerous source code examples showing how to integrate the VHPD1394 driver into an application.
The VHPD1394 software components can be integrated into a final product. Various product-specific adaptations (e.g. file names, paths, copyright messages) are supported. The result is a fully customized driver package that can be shipped as part of an end product. Customization prevents conflicts with other products that also use the VHPD1394 driver.
Using Thesycon's PnP Driver Installer, it is very easy to create a specific setup wizard that handles driver installation, un-installation and update in a comfortable and reliable way. For more information on PnP Driver Installer, check out http://www.thesycon.de/pnpinstaller.
VHPD1394 Demo is time-limited but has full functionality. The device driver can be used for 2 hours. After this time, all function calls will be rejected and the computer must be rebooted in order to use the demo again. The demo package includes the VHPD1394 device driver, the complete documentation and the source code of all programming examples.
Current Version: 2.31
NOTE: The driver described on this page is *not for use by end users*. It will not help solve any problems you may experience with a consumer device such as a webcam, camcorder, card reader, external sound card, etc. Thesycon's device drivers are software components intended to be used by hardware or software manufacturers to create end products.
VHPD1394 Application Design Guide
VHPD1394 Software License Agreement – Single Product License
VHPD1394 Software License Agreement – Unlimited Product License
VHPD1394 Software License Agreement – Source Code License
If you would like to be kept informed of product updates, please subscribe to the Thesycon newsletter.


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The Element of Freedom. Alicia Keys.
Through most of The Element of Freedom Alicia Keys sings processionals. They're slow, clean songs with semi-classical acoustic piano, soft-pop chord changes and simple, prominent hip-hop beats. They've nearly got a social purpose: They underline acts of inspired dignity, or informed desire, or virtuous defiance.


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Dear Dell and Microsoft: You're not Apple
Dell has always been a first-class choice for budget-minded CIOs. The company grew to prominence by shaving everything – including R&D costs – from the bill of materials for its utilitarian, corporate machines. Today, despite four years of attempts to invigorate its brand with consumers, Dell remains a consumer-computing laggard …
"And why is a company that has in the past built a truly great browsing experience allowed its internet expertise to languish?"
I was already sceptical about this article but this just made me stop and give up. I think it was referring to Microsoft.
Title schmitle
Agreed this is crazy talk.
The only sense in which MS ever won over other browsers was in number of installs.
Yes they were never that great, but
That's a little like saying "the only sense in which they were successful as a company was in having the biggest market share" - doesn't really damn them does it.
dell made it by shaving costs!
I agree, forgetting dell made it by being subsidised by intel was bad enough, but going on to say MS gave us a great browsing experiance really showed the writer as a complete idiot.
Next up Sony leads the world in secure systems
Erm Netscape
I think you need to go back and use some of the old alternatives to IE.
Netscape was a bloated clunky pile of junk. Only Opera provided a truly compelling alternative, but it was £30 or so to buy at that point and didn't work with all sites.
IE was fast and stable in comparison, it just had a lot of quirks when sticking to standards.
Giles is right!
while from a developer perspective writing web apps for ie 6 meant non-standard markup, from a consumer perspective that doesn't mean anything.
If using ie was as horrible an experience as these comments state the internet wouldn't have got this popular.....
Even with a desktop monopoly you don't get to 90+% market share unless you have the best all round product at the time. In reality apart from that EU browse choice screen MS still has the monopolistic advantage but user have proven themselves capable of seeking out the alternatives like FF and Chrome etc. This is worth doing because they are better.
It was only a while after IE6 had become established that mozilla and others got their act together by concentrating on standards, speed and of course being free/OSS which helps.
I LIKED Netscape Navigator 4...
Don't try to BS those of us that were actually there.
> I think you need to go back and use some of the old alternatives to IE.
I did at the time.
I had absolutely no desire to flee to the allegedly "superior" IE.
Opera was fast and stable by comparison. IE was not.
Opera wasn't free, so it isn't comparable really.
If you're old enough to remember, you know that for the better part of 10 years IE was the best free browser available on the internet.
I always favoured Netscape over IE. IE pissed me off every time, right up until today when I'm forced to use IE8 on my corporate desktop. It still force closes itself and stops responding with no explanation.
Miss it on Mac, cuz of banks....
"for the better part of 10 years IE was the best free browser available on the internet."
....even on a Mac
Though, Communicator 4.5-7 is a soft spot for me, as I used to use it constantly for the browsing and Composer back then!!! Ahh, to be 14 again.
Even though it's not well known, iCab on OS 8.5-6/9.x performed very well. And, if you think nobody knows about it NOW...... XD
"No, enterprise software is not sexy"
No they are not. Think Lotus Notes.
That is all...
Internet Explorer? On Linux?
Just not in their DNA.
Microsoft and Dell Need To Open Communications With Hobbiests
If they want to do better in the SOHO, home and hobby marketplace, Microsoft and Dell need to open communications with computer hobbiests and amateur enthusiasts.
They both need to stop depending on (often obnoxious) semi-blind amateurs helping blind amateurs in forums for consumer support and feedback.
They need to get actual employees talking to at least some regular home computer users, and they need to do this in places culturally different than just California and New York.
Listen to all types of consumers.
Engage with computer hobbiests??
What - both of them?
This is company trying to sustain billions of dollars of sales. Neither of the "hobbiests" has that kind of dough.
MS DO support hobbiests
MS actually support hobbiests far better than many other companies (games houses excluded) - look at any of the Visual Studio Express editions. OK, they're just trying to suck developers into their platform so that, in the workplace, they'll choose the paid-for version of Visual Studio - but if you just want to knock up a quick Windows app (a tool for modding data files in a game for instance) Visual C# Express is fantastic.
I don't remember seeing anything like that for Logic Studio (a rather good Mac music program) or Adobe Photoshop.
Windows success in the home is why it is a success at the office
Windows success in the home is the primary reason it is a success at the office.
You can hire people for any kind of position and they'll very likely be familiar with Windows already from using it at home.
I can't think of bigger reason why we use Windows instead of Linux.
It is the same with Office. So many more potential hires already know Office than know WordPerfect. And people usually have Office on their home computers already, so they can take work home.
Arse about face...
Not at all. Not even close. Windows success in the SOHO market is completely down to the fact it was what most people used at work. As a result schools and universities started mainly using Windows and Office because that is what the students were likely to encounter in the workplace. Computing, remember, started before 1995! Windows in the home is why it's successful in the office? Fuck me! Kid's today...
Agreed. In the office you are a prisoner. You have a set routine and you are using their productivity suite day-in day-out. What do you do at home? You go one of two ways - you get something else because you don't want to pay and/or just want something else, or you get what's familiar to you which can now be had for cheap by piggy-backing your home license on your workplace one. It's not the greatest deal in the World but it's a pretty smart move.
It's a cycle so you're both right, depending on which bit you're looking at
"Windows success in the SOHO market is completely down to the fact it was what most people used at work". Very true. When you were far more likely to encounter a computer on a daily basis at work than at home, people's working experiences with MS stuff played a large part in influencing what they bought personally when having an (IBM-compatible) PC in the home started to become the norm. If using a PC was a requirement of your job, training would follow and those skills were carried back to the shiny new 286 or similar in the living room.
Since that point, a new generation have grown up with access to a Windows-powered machine and entered the workplace with those basic skills ready to use. Training budgets are now focused far more on specific tasks or applications and it isn't expected that a new hire is going to spend their first month trying to figure out how to use their computer instead of learning their job role. It's now reached the point where the scales have tipped entirely the other way and a lot of companies (who's IT involvement is purely out of necessity rather than their core business) are locked into MS primarily because that is all they can expect any new employees to be able to use.
The way out of the cycle is to re-train them to be as comfortable with an alternative (likely cheaper, more secure and arguably better) OS than Windows, which will ultimately change which OS the new generation of kids will be comfortable using. As that takes a significant investment of time and money in their employees, very few companies do.
I reckon Keith T's opening line should have read "Windows success in the home is the primary reason it is STILL a success at the office".
No. It was DOS vs. MacOS.
> Windows success in the home is the primary reason it is a success at the office.
What? Were you just born yesterday?
DOS was a success in the office before Windows even existed.
The dominance of Windows is an extension of the dominance of MS-DOS in the workplace, not the other way around.
I'm just wondering....
WHICH US school corporations these people visited in the 90s. Every one I went to anywhere around the entire Midwest had a much larger number of Macs than they did DOS/WIN boxes.
Some still DO!!! XD
And so do they everywhere else in the world! Take you fanboy glasses off, stop trolling and look at the facts. It's mactards like you who give the rest of us a bad name.
Wow, not trolling at all...
In fact, I was merely expressing my experience....
...and I don't wear glasses...
And with the name calling....sounds like someone's annoyed by what I stated to be my own personal experience. Oh, and I never said anything outside of the Midwest, did I? At any point. I'm pretty sure you are showing your colors a bit more than I.
In fact, I am extremely at odds with Apple in the direction SJ has taken them. I long for the days of true innovation and vision that Woz brought to the table. SJ is just more about screwing others with lawsuits and keeping everything under his ultimate control. not to mention the big FUCK YOU they threw to the enterprise users by dumping XServe.
Thanks for playing!
Completely agree...
certainly with the point that Microsoft don't get consumers. The thing is that no matter how hard they try, they just aren't cool and like it or not, cool matters to consumers. The XBox team should really be the driving force behind consumer products for Microsoft and perhaps given a degree of autonomy. Dell on the other hand should just give up! Snap-on covers are so 1998.
I much agree with you and AnotherNetNarcissist
And I quite appreciate articles bye Matt Asay but there are some things to remember.
The Personal Computer was never meant to be a business computer, it was designed to be
a personal home device.
The fact that it was adopted bye business is the most expensive failure to have happened
to business.
Gates is truly a guy who was looking for the mass market. When Windows did well he had a look at the Fortune 500 and realized that there where other mass market devices too, like music players, game consoles and cell phones. That we can do too, he said, and I will become the Chief Architect because I invented the computer.
Even the Xbox is a failure, money wise, as it has probably not made any profit yet, considering its development costs.
It is a bit hard to compare Apple and Microsoft. Apple has always done both the OS and the design. Jobs does have a clue about design, also he was wise enough to adopt a *nix* OS.
Also he was there when inventions happened while Gates was there more or less bye accident
(an accident bye IBM).
Dell a hardware producer like so many others. Do they produce anything in the US any more.
GATES sucks.
Yes. Billy made his money by lying and cheating. Then he made SERIOUS buck as a result of that lying and cheating.
The fact the the OS materialized, got better, sold better, .... whatever.... is all fouled with the fact the Billy lied and cheated his way to that position.
Microsoft must die as a company. I don't spend a dime on them or there property. More and more folks are doing the same. Can't wait for the day that MS declares BK!
~LOL~ I so agree!
Snap on covers are soooo 1998! LOL!
Re: Gates sucks
Oh come on. Find me the head of a massive corporation who got there by being nice and cuddly. Mark Zuckerberg? Fred The Shred? Larry Ellison? Grow up, dude, it's a big bad world out there.
Help Please
I don't know if I should give the thumbs up or down this. Is it sarcasm or a foam lipped rant.
Any suggestions?
@Mark Serlin
In fact I would go as far as to say if you aren't a self-centred stubborn prick you don't stand a chance.
It's just another Turing Machine. Really...
> The Personal Computer was never meant to be a business computer, it was designed to be
You're kidding right?
The PC was specifically designed as a business machine. It was designed as a business machine to keep the up and coming home computer company at the time from invading IBM's turf.
The PC was designed by IBM to sell to businesses so they wouldn't be tempted by the likes of Apple.
No, I am not kidding. At the time the Micro Computer had arrived. There was Radio Shack and Apple and others. So they had to do something, very reluctantly.
The PC, bye IBM was downgraded internally as there was in fact people within IBM who where afraid that that Home Computer would be a threat against their minicomputers.
Originally they wanted a decent processor too (Motorola) but then downgraded to Intel.
The book "Inside Intel" is a very readable book, with a lot of inside information about all of this.
One very interesting part is where the people from Intel wanted to help the Microsoft programmers to use the processor in a better and more advanced manner.
The Microsoft programmers response to that was - that does not matter, all that matters is features.
do what?
>a company that has in the past built a truly great browsing experience
Which company is that you are talking about coz it certainly ain't Microsoft!
Well, being fair
At the time IE6 was released the other browsers were pretty crap so
* At the time
* Compared to other browsers
I suppose you could call it a 'truly great browsing experience' (although I agree that is pushing it a bit)
I think that is what the author meant
... an early Mosaic lately? Old enough to remember it and Gopher?
Although to be fair
Internet Explorer didn't exist when early Mosaic was kicking about. And yes, I remember it (when it wouldn't display pictures in the browser), and gopher too.
I do agree with you in principle though - Internet Explorer first appeared at version 2, and was rubbish. v3 was actually not bad compared to its peers (namely Netscape 2 and 3), and even though IE5.5 was an abomination for developing to, it was rather nice to use (again, compared to the bloated struggling mess that was Netscape 4).
Just because Microsoft declared the internet finished with IE6, and let everyone else actually do the job of making browsers conform to the standards, their browsers have *generally* been quite nice to use. That said, I can't remember when I last loaded IE on this machine - I'm using Firefox 4, and rather liking it.
re: Tried...
Scarily, I _am_ old enough to remember Mosaic and Gopher. Aughh.
Seriously, though... now that you mention it, I've often had a curious urge to dig out my old copy of Mosaic -- yeah, it's still buried in a pile of backed-up stuff on an old Zip cartridge someplace -- fire up my old G3 Mac running OS 8.x (still sitting around the studio, believe it or not), and see how many current sites it can load without imploding.
Can't think of a better title. Some of the author's views on Dell seem reasonable. But his views on Microsoft are just plain wrong. Microsoft has had huge successes in the consumer market. The entire Windows 95 product line was focused primarily at the home user. The fact that until very recently PC games were generally only available for Windows is another pointer towards this. This was one of the key reasons Microsoft went out and created the XBox. They could see Sony making a lot of money with the playstation, and figured that they could easily create a gaming console using DirectX and Windows under the hood. Xbox 360 and Kinect have been hugely popular.
Windows still has a massive market share (according to StatOWL for example, Windows has over 85% of residential market share). Both in consumer and business land, Windows is by far and away the most popular OS. By many measures Vista has more market share alone than OSX, and remember Vista was almost completely untouched by businesses: http://en.wikipedia.org/wiki/Usage_share_of_operating_systems
If Microsoft decided to concentrate on business at the expense of consumer, they would make a lot less money. Microsoft have been successful because of a synergy between the 2 markets. All your corporate software works on Windows so you get it at home, but also all the games and media stuff you want at home also works, so you are happy paying for it at home.
Hell Dell
Hello HP
Here we are together
I'll just leave the room so you two can get to know each other better - a lot, lot better yes?
Both are right
Windows is successful because it is used in the home
Windows is successful because it is used in the office
In summary windows is successful because normal people (that is not you and I) aren't really aware that there is anything else.
Windows is successful because you can hardly buy a PC without it.
If every car from every manufacturer came with wooden wheels then it would be incorrect to say that wooden wheels are successful because everybody had cars with wooden wheels.
Well, it would actually, but not because wooden wheels are popular or better, but just because people don't have much of a choice in the matter.
It doesn't help that they already have that special wheel changing tool that only works on wooden wheels and sort of know how to use it. A bit. So what if they get a bunch of splinters and the wheel often breaks whenever they have to rotate their tyres? They're used to that happening and probably think they'd have the same problem with alloys anyway so why bother changing?
So yes, say that Windows is successful because of Microsofts strong-arm bully boy behaviour but don't point to the number of people who use Windows and try and tell me that they are all using it by choice.
Windows is successful because you can hardly buy a PC without it
"Windows is successful because you can hardly buy a PC without it."
I'm really getting sick and tired of this nonsense. Just by repeating it doesn't become true.
There really are plenty of PCs available without Windows, both from plain assemblers and big brand names like HP or Dell. This of course is over the widespread availability of generic components to build your own PC.
If you really believe that you can hardly buy a PC without Windows I would suggest to sometimes lift your butt from that couch and open your eyes.
@Goat Jam
I think the problem is that we're now past the point where the bundling matters. It served it's purpose to the point that if you ship a machine to the general public (not the Reg readership) that has linux installed they will likely come back asking for windows. Not because it's better, not because they cannot do what they want to, but because it's bloody everywhere. This means that finding someone to demonstrate how to do things is easy, getting add-ons that work is easy (plug in, insert disk). Familiarity is there. Oh, and the apps for those that need them. The fact that for years you've had to run performance crippling AV software on Windows, or reinstall the OS every 18 months (XP), or constantly update the bastard really hasn't dented the desire for the OS. That should give an indication of what any other OS is up against. I have to use it at work and don't in general at home, but respect the stranglehold that it has.
Think Stockholm Syndrome for operating systems. People are using it by choice in a kind of fucked up way.
Windows is successful because...
Windows is successful in the office because, as the old saying goes, nobody ever got fired for buying Windows.
@Mark 65
I agree, to a point.
I also wonder whether at point of purchase, if people were asked "and what OS would you like for that $500 PC sir? Windows @ $249* or Ubuntu for free?"
If people actually knew what percentage of their PC purchase was made up by the windows tax + av subscription I'm sure that a significant number would be willing to give the free option a go. If more people did that then momentum would build and we could maybe break out of the stranglehold that MS currently has on the general public.
The bottom line is that MS should NOT be allowed to force Windows onto every PC and the cost of purchasing it with a PC should be a line item on the invoice. The real problem here is that MS have social engineered the entire population into believing that somehow they get Windows for free when they purchase a PC so Free Linux is in effect competing with free Windows and has no hope in such a battle.
Here, have a free beer
* http://www.microsoftstore.com.au/shop/en-AU/Microsoft/Windows/Windows-7?network=clixGalore
"Think Stockholm Syndrome for operating systems."
That's perfect. Windows (and Office, and IE) is the definitive "devil you know."
Dell's Roots Are In Consumer!
Dell built itself from the ground up as a consumer company. Remember Dell was the first to offer great value on customized mail-order PCs. Enterprise came later.
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A local BMX star is getting national attention this week. Brett Banasiewicz has been named Toyota USA's 2012 athlete of the year.
Banasiewicz was one of three finalists. Anyone who competed in the Dew Tour was eligible.
Banasiewicz is still recovering from a head injury from a serious BMX fall in August.
In response to his injury, several major competitions, including the Dew Tour and the X Games, now require athletes to wear certified helmets.


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