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I tried so many but this is the one I always go back to. Great smell, stays forever, and you get compliments from everybody around.
Very expensive but also my fav fragrance. It just makes me feel sophisticated.
Have been wearing this 7 years, it is my go-to fragrance and I highly recommend. It is rare that I do not get a compliment while wearing this.
You don't need to apply much to get the perfect amount
Hmm hmmm hmmmmmmm! Was that weird? lol well that's what comes out of my mouth every time I put on this baby!
I have always been a fruity perfume kind of girl. And this is just what a fruity perfume kinda girl needs :) so fresh and young and still so sophisticated.
I must say that I don't have the normal bottle which is really pretty. I got the twist and spray perfum version that comes with two refills. The idea of that is just amazing! it just fits in my bag, purse, when I travel. Just perfect! I will see if I can upload a photo of it.
This darling baby has never failed to get me lots and lots of compliments. It's just marvelous.
I got this as a gift so I really can't comment on the price. But excuse me? it's Channel! so of course it's pricey!
xoxo Lolitagirl ;)
I just wanted to hate Coco Mademoiselle; lets check out my list of complaints:
1) I usually dislike fruity perfumes. Fruit should be eatendang it!
2) The note listing = boring cliché line-up. Yayanother fruity-floral with a dash of patchouli. Bleck.
3) Its painfully ubiquitous.
Anyway, Mademoiselle is, indeed, all of the previously mentioned items; however, in spite of the reality surrounding this fragrance, I still enjoy it. First, the citrus fruit somehow sticks around past the opening and blends with the patchouli and lychee creating a warm, pink haze that weaves through the composition. Below the pink haze is a touch of musk and above the pink haze one can detect the icy fluttering of jasmine and rose. The floral component is high quality and can be found in other Chanel fragrances; IMO this is one of the features that keep Mademoiselle from sliding into the pit mediocrity. An hour later, the delicious patchouli-vetiver-tonka combination takes over. This is, by far, my favorite phase and Im shocked at how much my wrist finds its way to my nose. After the release of Coco Noir and Chance, I have a newfound appreciation for Mademoiselle
4 out of 5 people found this review helpful. Did you? Yes No
I adore this fragrance. It screams sophistication but without the granny-like character of Chanel No. 5. More of a fall/winter scent in my opinion, though it's certainly wearable year round too. I will definitely repurchase this when I run out, but I may try the EDP next time as I currently have the EDT and I want just a little longer lasting power.
This smells absolutely fantastic! I always thought of this of a more mature fragrance, since my grandmother often wore it. However, lately I've been going through a major perfume phase and I realized that I love this scent on me now too, not just when I'm older. I purchased the 1.7oz bottle today and I cannot wait to wear it tomorrow! :)
Coco Mlle and Classic Coco are both must-tries (and must haves for most) for the fragrance lover.
The light, airy top note fades into a powdery floral with a hint of green and a hint of orange that I enjoy.
Beautiful 3-season (Spring, Summer, Fall) fragrance for me. YMMV.
smells really good! i love the soap tooo!!!
I am doing this review on the coco mademoiselle twist and spray eau de parfum. I first sampled this perfume about 4 years ago but never purchased due to the price, but I recently decided to treat myself! I purchased it for myself for £75.00 from boots online. It comes as a 20ml test tube shape bottle which is inside a white enamel casing with gold up each corner. The box is simple and classic looking, with the name gabrielle chanel across the front as well as all the other info.
The box contains another 2 bottles of the perfume which are refills for the cannister so you get 60mls of eau de parfum,
This actually seems quite good value and when you work out the price of the perfume per 100ml, the twist and spray is cheaper than the 35ml and the 50ml bottles (per 100ml) but more expensive than the 100ml bottle.
To use the perfume you simply twist the top part or the bottle and the large gold button emerges with the spray nozzle and just squirt as you would usually, then twist in the other direction to close so it cannot squirt in your bag. The liquid is pink in colour. To change a bottle once its run out just pull out the old bottle and replace with the new and put sprayer button back on.
The fragrance itself is sweet and fresh, but it is classic and expensive smelling, You can tell this is a real quality perfume when you wear it and it is very sexy. Its not simply fruity floral perfume, its got depth to it. Not like so many perfumes you smell in the shops. I think it could be worn day or night as its not heavy, but I will save mine more for going out and not for work. I can put this on at night and my husband can still smell it in the morning!
I'd say this is marketed for the younger women who cannot wear Coco as its too heavy and strong, I'd say its for people between 20-40 but any age could wear it really.
Some people say the scent wears off quickly, I disagree, there are a lot of fakes around of the 100ml eau de perfum coming in from europe, and I recommend not purchasing from online auction sites as you may well be buying counterfeit goods and they look just like the original in terms of the packaging and bottle, so do yourself a favour and purchase the real thing as we all know quality sells itself. I wouldn't be suprised if some of the reviewers on here had received theirs as a gift purchased off an auction site and that's why its not lasting very long! These large bottles cost £93.00 a lot of people cant afford this to give as a gift so will go to online auction sites to spend £50.00 instead.Its better to simply purchase the smaller bottle.
All in all I give 10/10 for this, its beautiful in so many ways and I will always keep my supply stocked up!
Prices for the eau de parfum are: 35ml- £46.00, 50ml- £65.00, 60ml twist and spray £75.00, 100ml-£93.00
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TRB Chemedica (UK) Limited continually strives to be an employer of choice in the UK in order to attract and retain individuals with the best skills, attitudes and standards.
Staff retention is extremely important so we place top priority on career progression, development, pay and reward and a pleasant working environment. 25% of TRB Chemedica (UK) Limited's staff have been employed by the Company since its inception in 2002 and another 30% have been with the Company for more than four years.
TRB Chemedica (UK) Limited's focus is first class customer service and delivery of innovative, novel products and it is through our people that we accomplish this.
Training and development is ongoing for all staff and significant funds are dedicated to this.
Work-life balance
We appreciate that work is only one aspect of our employees' lives. To help staff fulfill all of their commitments in and out of the office, we have introduced home computers/laptops with remote desktop connections to allow people to work from home. We also offer a choice of benefits to our staff which most suit their individual needs.
TRB Chemedica (UK) Limited is an Equal Opportunities Employer.
Current Vacancies (3):
Application Form (pdf)
- The North West of England
- London & Home Counties
- The South of England
TRB Chemedica (UK) Ltd is the UK subsidiary of TRB Chemedica International, based in Switzerland, an innovative, research-based bio-technology company specialising in the manufacture of bio-synthetic treatments for a variety of medical conditions.
We have 3 vacancies for bright, ambitious, motivated and enthusiastic graduate sales representatives to promote our rheumatology and ophthalmic products to customers in the NHS and private practice in London & Home Counties, the North West, and the South of England. The successful candiates will be expected to demonstrate exceptional levels of activity, with a correspondingly high level of business generation.
You will be a life sciences graduate, with excellent language and presentation skills. You will have excellent IT skills and you will be resourceful, energetic, and determined. A clean driving licence is essential as these positions entail significant travel within the UK.
We offer a generous basic salary, as well as a company car, private healthcare, pension and a profit related bonus following the satisfactory completion of a six month probationary period. Comprehensive training and on-going field support will be provided.
To apply please complete our Application Form and send to: firstname.lastname@example.com.

subset: commoncrawl


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High-strength, trowel grade, latex-based adhesive for installing ceramic and mosaic tile to floors, walls and countertops. Easy to spread, quick-grab formula requires no bracing. Provides excellent water resistance. Nonflammable and easy water clean-up. Interior use.
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DAP Products Inc. is an operating company of RPM International Inc.© 2014 DAP Products Inc.


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Countryside Alliance Champion of Champions awards.
You are reading the home page of the website of the Chalke Valley Stores (shop, post office and coffee shop) which opened in Broad Chalke on 3rd June 2013.
On May 1st 2014, less than a year after opening, we were voted the UK's Best Village Shop / Post Office in the Countryside Alliance Awards.
Change of web site page for Countryside Alliance Vote – please read this even if you have already voted
November Newsletter: So much going on: Vote NOW, Chalke Valley Wine and Cheese Event, Hub'n'Pub Christmas Evening, Christmas Goodies from the Stores, Cyber Cafe coming
October News Letter: A busy summer, new suppliers, Champion of Champions Awards
July Newsletter: new products and new faces
Chalke Valley Stores opened on the 3rd June 2013 in the premises of the URC Chapel in High Road, Broad Chalke. The full facility (also known as the Chalke Valley Community Hub) offers both retail and community facilities
Retail facilities
- A village shop
- Outreach Post Office
- Coffee shop with wi-fi services
- Collection point for deliveries, dry cleaning etc
The shop stocks a wide range of everyday and special products, with a focus on locally made and fresh produce. Our range includes:
Daily delivered fresh fruit & vegetables
Fresh bread and hot pasties, sausage rolls etc
All baked on the premises daily
Delicious home-baked cakes, quiches, pies and pastries
Fresh coffee and cakes in the Coffee Shop 10-12 am & 2-4 pm daily
Fresh meat from Manor Farm Meats and other local suppliers
(special orders taken – e.g. for your Sunday roasts!)
Organic Chicken from Angel Cottage Farm every 3rd Wednesday of the month
Local organic beef from Cools Farm available monthly
days to be announced
Super organic bread from Henderson's Bakery every Saturday
Proper bread made the old-fashioned way – Wholemeal, sourdough a speciality – and 'Pain Rustique is excellent!
Daily Newspapers and free Wi-Fi connection
Dry cleaning pick up / drop off on Wednesdays
Community facilities
- Meeting rooms/worship area
- Information centre
- Chalke Valley Benefice Admin Office
- Village archive, small library and book swap
- Police drop in
The Hub is a facility for the whole of The Chalke Valley and not just for the village of Broad Chalke. It is strategically located in the URC Chapel on the main valley road in Broad Chalke in the heart of the Chalke Valley. Map.
More Information
For further background information please visit About Us
The Contact page has, not unsurprisingly, contact details. You can also subscribe to our emailing list to be kept up to with the latest developments.


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|List A - Z | Top 1000 | Random | Origins
AsayaRate Asaya: Do you like this name?
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Asaya meaning and name origin
Asaya \a-sa-ya\ as a boy's name has the meaning "God has created" and is a variant of Asael (Hebrew): biblical name.
Asaya is also pronounced similarly to Asa and Isaia.
Popularity of Asaya
Asaya is not a popular first name for males and an equally uncommon surname or last name for all people (2000 U.S. Census).
Displayed below is the baby names popularity of Asaya name for boys (2012 statistics). Compare Asaya with its source form and related boy baby names.
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U.S. Sen. Bob Corker addresses fiscal and foreign policy issues with the Rotary Club of Cleveland on Tuesday.
Photo by Paul Leach .
published Tuesday, May 28th, 2013
Stories this photo appears in:
CLEVELAND, Tenn. — U.S. Sen. Bob Corker, R-Tenn., said Tuesday that the nation's economic recovery and ongoing success depend on aggressively addressing its fiscal problems and creating better policies to deal with China and intervention in the Syrian crisis.


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- You are here:
- Photos >
- suzuki palette sw
It's o-kei! Suzuki Palette SW introduced in Japan
by Alex Nunez (RSS feed) on Sep 19th, 2009 at 3:33PM
You're Japanese. You have a family. You need a minivan. But minivans are freaking huge, Japan's streets are crowded, and you want something that's a lot smaller and can dart between lumbering dekotora lit up like Vegas. So, you look to a kei minivan because it's teeny tiny. Suzuki's got your back with the Palette, the micro-mini minivan it introduced back in early 2008. It's totally neat in that way all Japanese kei cars are, as its compact size belies interior storage capacity capable of swallowing up literally hundreds of packs of Dentyne, several vintage Super Famicoms, and that box of... Read More


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Crimes at the Dark House
64 minutes.
Directed by George King
Cast: Tod Slaughter, Sylvia Marriott and Hilary Eaves
Country: Great Britain
Film / Drama / Horror / Foreign
Percival Glyde is murdered in his sleep with a wooden spike that is hammered into his skull. His killer steals his identity and moves into Glyde's London mansion. The family lawyer who has not seen the real Percival since he was a boy informs the madman of Glyde's arranged marriage to the beautiful heiress Laurie Fairlie. Greed and perversion drive this lunatic to the brutal killing of anyone who attempts to unravel his secret identity. Crimes at the Dark House is one of many horror films starring British actor Tod Slaughter and directed by George King. Based on a novel by Wilkie Collins, this story was adapted a second time for the 1948 Warner Brothers film The Woman In White.
Crimes at the Dark House Prevu


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Former CIA Director and Army Gen. David Petraeus and Paula Broadwell, co-author of "All In: The Education of General David Petraeus." | Photo made available on the International Assistance Force's Flickr site.
Updated: January 21, 2013 3:49PM
Our Illinois legislators should all be armed and patrolling schools within their districts when the Legislature is not in session.
These dedicated public servants work part time while receiving generous salary and pension benefits from the taxpayers. This is an opportunity for them to do some volunteer work that would protect our children and put them in daily contact with their constituents. It also would get them off the additional government payrolls that many of them now occupy.
Mark S. Renz, Oak Lawn
Don't rush in new laws
Never make really important and long-lasting decisions in the heat of the moment. Unfortunately, Americans did this when they passed the Patriot Act after 9/11. This greatly expanded the federal government's powers to lengths most people don't realize.
It gave the government power to invade our privacy without much justification. Would we know about David Petraeus' non-criminal extramarital affair without the Patriot Act? Doubtful. We must also use caution attacking one of our inalienable rights in the heat of the moment following the horrible massacre in Connecticut.
Tom O'Brien, Dearborn Park
Allow guns in court
I am very conflicted about recent judicial rulings allowing everyone to carry guns, except in courtrooms. What are all of these judges afraid of? If someone gets out of line, they can just pull out a gun from their black robes and shoot them.
Melanie Wojtulewicz, West Lawn
A time to overreact
To those screeching, "Don't overreact! Don't overreact!" I reply, weeping, "How can I not! How can I not!"
Barb Tomko, Ravenswood
Mental health care needed
The entire country has been shocked by the Connecticut school shooting last week, and while mourning the victims, also feeling a sense of urgency to understand how this tragedy could have been prevented. With so many details yet to emerge, it is impossible to know whether the proper mental health treatment could have helped Adam Lanza, but there is no question that this terrible event will lead to many conversations about the state of mental health care in this country.
After all, there may or may not have been mental health signs that should have triggered intervention in this case, but if there were — and they were ignored — we could never forgive ourselves.
It is exactly for reasons such as these that many community hospitals like Saint Anthony remain committed to offering critical mental health care, even as others are shutting their doors to these patients. Why would they possibly do that? In the case of the State of Illinois and Gov. Pat Quinn's office, it's a budget issue. These patients cost more and the budget is in crisis, so the state shut down its facilities that serve this population, increasing traffic to hospitals such as ours. And the scary truth is many of these remaining hospitals are considering a similar decision due to readmissions penalties.
On the surface, the readmissions penalty makes sense: It penalizes hospitals that release patients who are then readmitted for the same issue at theirs or another hospital. This should encourage hospitals to implement new practices to reduce such cases. But the devil is in the details — consider that mental health patients have a higher readmissions rate than the average patient, so hospitals that serve a higher mix of patients with mental health and psychological needs face higher penalties. Now, you can understand why the base of services to these patients is shrinking.
If you, like me, are struggling to find a way to take action based on the Connecticut tragedy when there is so much that is out of your control, one thing you can do is support your local mental health providers and fight back against unfair policies that penalize them — and require them to release patients back on the street who need further care for their own safety and that of others. Contact your local elected officials and tell them now is not the time to turn our backs on patients in need.
Guy A. Medaglia,
president and chief executive officer,
St. Anthony Hospital


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Wallenpaupack Area Little League All Stars set to host 2014 tournament title tilt.
Dave Granlund cartoon on Mitt Romney.
LeBron James�is coming home. The basketball star announced he's returning to play for the
Elementary�has cast newcomer Ophelia Lovibond as Sherlock Holmes' (
A Comic-Con tradition continues! For the fifth year in a row TV Guide Magazine and Warner Bros. Television are teaming up for a special issue with behind the scenes scoop and photos from some of TV's biggest hits. The magazine...
Several decades from now, when historians look back at the beginning of the end of the expensive, wasteful and tragic American War on Drugs, Jesse Snodgrass may very well be mentioned prominently.
There will be a preview of the CROSSINGS, presented by WCM's Summer Music Festival CROSSINGS at The Cooperage at 7:30 pm...
Something to Talk About
[WARNING: This story contains spoilers from Season 2 of�Orange Is the New Black. Read at your own risk.]�Daya and Bennett have very different ideas...
- Events Calendar


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Driver's sandwiched between two thick layers of cotton wool held in place by a string wound tightly in a sloppy manner around the whole thing. Additional cotton wool inside the cups does whatever it is it does.
One might intuit that this mod would worsen the sound - but one would be wrong.


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RT @CCSkills: Diolch @NTWtweets @jontreg @mrmarcrees for launching the Welsh NSA live brief competition in @CAVC and @ColegSirGar this month
UCAS Code: C22
Course Code: W290
The college has an established reputation for facilitating the creative development of art and design students. This new course has evolved in response to contemporary art and design practice, culture and industry and is available bilingually, where students can choose to be taught and supported through the medium of Welsh or English.
In the rapidly growing and changing world of visual communication, graphic design can be best described as 'making an idea visual'. The course gives learners the opportunity to develop problem-solving skills as well as working in 2D, 3D and with the moving image. Students will explore the use of words and how they communicate using typography. The course seeks to equip you to work in this exciting and diverse industry, developing creative attitudes and skills within a variety of media, both traditional and digital. The course introduces you to essential graphic languages and processes including digital image manipulation, traditional and digital drawing, typography, branding, advertising, 3D & 2D visualisation, web design, motion graphics, print-making, advanced desktop publishing, preparation for print and along with new technologies, project management. Focusing on some of the major areas in contemporary communications, this course helps to promote the creative thinking processes together with introducing the skills required to enter the creative industry. The programme can also offer individuals an opportunity to create work in a bilingual context and environment. Your practice is supported by an integrated theory programme enabling you to work confidently and professionally within the context of graphic communication. The School of Creative Arts, provides a friendly and supportive environment for students to explore their options and develop their individual style and potential.
Freelance design practice, publishing, advertising, branding Web design, exhibition design, studio management, art direction, television graphics, sign manufacturing, teaching / lecturing.
Tariff score points accepted 120. In addition applicants would normally be expected to have achieved English or Welsh language, mathematics to a minimum of C at GCSE. Selection procedures offers will be made based on UCAS application predicted grades, reference and interview. On receipt of the UCAS application students will be invited for interview where they would usually be expected to present a portfolio of art work. Programme co-ordinators will interview prospective students. Mature applicants with relevant prior experience are welcome and are considered on an individual basis. International students will be interviewed by video conferencing. At interview the candidate will give evidence of current experience and reasons for undertaking undergraduate study. He/she must demonstrate at interview that he/she is academically and technically/practically capable of completing and benefiting from the programme. Academic certificates and relevant documentation will be checked before unconditional acceptance.
RT @CCSkills: Diolch @NTWtweets @jontreg @mrmarcrees for launching the Welsh NSA live brief competition in @CAVC and @ColegSirGar this month


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Military payments for biofuels flagrant
In his commentary July 29, Lt. Gen. John Castellaw lauds the efforts of the military to convert to new biofuels. Imagine how much fuel an aircraft fighter wing unit would use in a month. Planes are constantly training, taking off and landing on carrier warships, training pilots for wartime. Thousands of gallons?
What the general selectively failed to mention is how much this new biofuel costs. In 2009, the service paid $425/gallon for 20,000 gallons of algae-based fuel ($8.5 million). Later that year, the service paid $67.50/gallon for 40,000 gallons of fuel from the camelina plant ($2.7 million). The Navy is now paying $26.60/gallon for 450,000 gallons of biofuel ($12 million) to power a carrier strike group off the coast of Hawaii this year. Are you kidding me? If the economy was booming, maybe. But with a $1.2 trillion deficit, these people are nuts.
People in this country had better educate themselves about what's going on in our government. It has been hijacked by a group of people who have an agenda that they will perpetrate at any cost. They care less about the plight of the country or the American citizens. We can't afford four more.
TAYLOR E. CAVIN, Hixson
Think about where food comes from
Just pondering — Chick-fil-A is being punished for its values and beliefs. Think about this ... my husband grows chicken. Chicken that is served at Chick-fil-A and many more restaurants. We do not support gay marriage. Does that mean folks who do support it shouldn't eat our chicken? If anyone is boycotting Chick-fil-A then why not boycott every restaurant that serves chicken raised on our farm?
I believe in God and the Bible. I believe in traditional family values, but I don't care if conservatives, liberals, heterosexuals, homosexuals, Christians, Muslims or Hindus want to eat the chicken we grow. If Chick-fil-A's beliefs bother you then you should think about where your food really comes from. Most farmers are God-loving people with very traditional family values.
If you are concerned about supporting Chick-fil-A then you should buy some chickens, cows and pigs and brush up on your gardening skills because I can assure you that each time you pull through that drive-through or go to a dine-in restaurant, you are supporting a farmer and his family and he will likely be in church Sunday, tithing (money made from you) to support traditional family values!
Political correctness goes both ways
Clay Bennett's Aug. 1 editorial cartoon shows the word "INTOLERANCE" spelled in cutout letters, including Chick-fil-A's trademark "C."
Obviously it was in reference to Dan Cathy, CEO of the privately-held, family-owned restaurant chain who affirmed his personal belief that "the biblical definition of the family unit" includes marriage between a man and a woman.
When are the politically correct police going to admit that intolerance also applies to people like themselves who cannot — or are unwilling to — tolerate others whose beliefs and worldviews differ from their own?
ROBERT J. TAMASY, Hixson
Alicia Morrison: Your chicken is not the issue here. CFA is at fault only because of the funding it gives to political anti gay organizations. I don't care if you or anyone believes in Biblical principles as long as they are not discriminatory against people in hiring or serving policies. CFA doesn't need to be involved in politics, since it's a corporation.
Robert Tamasy: I do not tolerate people who violate basic political reasoning and decide to use their company's money to fund anti gay organizations who are trying to use their influence to persecute and discriminate against gay people. I can respect them as a person, but ideas do not automatically gain respect because a person holds them, whoever they are. I think even President Obama, a good man, holds ridiculous ideas in terms of philosophical beliefs concerning the afterlife, etc. But I respect him as a person. Same as you, Dan Cathy, even the people of Westboro Baptist Church. but ideas are not afforded the respect I give to people, even if they are deeply important to them.
Tolerance of others does not mean tolerance of their ideas. I am only intolerant of a businessman using his public accommodation as a source of funding for anti gay propaganda.
TAYLOR E. CAVIN, if you want to object to the excessive spending on the military, go right ahead, but don't narrowly tailor your remarks to biofuels.
There are plenty of carriers groups going around, and many of them are deployed just because of the Middle East.
You are, however, nuts yourself if you think you can just shut them all down. Let's keep 6 or so of them.
ALICIA MORRISON, to be fair, the entire agricultural industry is so replete with abuses that many people opt-out in general. Not Steve King though, who thinks it's offensive that we have laws against animal abuse that don't apply to humans.
But here's your mistake. You're saying Cathy just believes something. Wrong. He's funding groups trying to put his beliefs into legal effect. He supports discrimination in the laws.
Go to church if you want. That's fine. But when you go to a politician and try to get them to vote your way, that's where you subject yourself to public criticism.
ROBERT J. TAMASY, sometime after our brains fall out of our heads. You are making the classic mistake, that "tolerance" requires one to "tolerate" your "intolerance" which is just the petty whining of bullies everywhere.
Really, why do so many people try that faulty logic? Do Bigots actually think that the real bigots are the ones who won't let them oppress and discriminate against others?
Besides as I just said, he wants his personal beliefs to be laws. Are the rest of us supposed to just sit around out of your misconceived distortion of tolerance and let him make whatever laws he wants?
Wow, that biofuel data was really amazing! With military venture capitalism the price went from $425/gallon to $26.60/gallon in just three years and they were able to produce 450,000 gallons? That's tremendous progress. At that rate of progress, biofuels will soon be cheaper than middle eastern oil and we won't be supporting terrorists and extremist regimes with our taxpayer funded military spending. Think how many American lives and billions of dollars we could save if we didn't have to constantly police that area of the world in order to secure that resource. Which is kinda the point. I bet nobody would object to spending $20 million on better body armor to save the lives of our soldiers, so why not spend that much so you may not have to fight the next Middle Eastern war?
Leaf, what are you doing thinking of the future? That's just plain unacceptable. And suggesting that we abandon our overseas military ventures just because it would spare lives? What about American prestige and glory?
Also, they did object to spending more on better body armor, they cheaped out.


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Campus Media
La Vie Collegienne
A weekly newspaper written for the College community, La Vie Collegienne is a student-organized and student-produced publication. With the help of a faculty advisor, students become active in all phases of journalistic work including reporting, writing, photography, advertising, editing, and layout. Staff positions are open to all students.
La Vie Collegienne invites responsible comments from the College community in its "Letters to the Editor" Section.
WLVC is the student-operated campus radio station. Staff positions are open to any student interested in broadcasting. Student DJs create their program formats and broadcast live. Recent formats include hard rock, punk, top 40, pop, progressive, jazz, classical, and ska. Students also program and broadcast weekly topical shows. Students can listen to WLVC by visiting http://wlvrradio.lvc.edu. Students can contact WLVC at email@example.com.
Lebanon Valley College
101 N. College Avenue
Annville, PA 17003-1400
Student Affairs 717-867-6233


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During flight the engine started to smoke, and then it quit. The pilot immediately turned towards a known field and made an emergency landing. While landing, the propeller stopped in the vertical position and caught on the uneven terrain resulting in the aircraft nosing over. Postcrash examination of the engine revealed a cracked crankshaft.
The National Transportation Safety Board determines the probable cause(s) of this accident to be:
Index for Nov1995 | Index of months


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Facebook Gets Stingy With Social Graph and 4 Social Media Stocks Seeing Action
+ More Articles|
January 25, 2013
Facebook, Inc. (NASDAQ:FB): Current Price: $31.60
This week, Facebook has prevented a number of services from using its Social Graph. The company hopes to keep the information of who people's true friends are out of its competitors' hands.
Markets are at 5-year highs! Discover the best stocks to own. Click here for our fresh Feature Stock Pick now!


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12 languages
Seo In Guk is a South Korean actor and pop singer who rose to popularity after winning the talent show "Superstar K" in 2009. Born October 23, 1987, the singer openly discussed his struggle with bulimia after being told to lose weight by judges at an audition. He also starred in the 2012 television drama series "Love Rain." Watch the music video of his song "Love Again."
This wall is managed by the community. Have an idea and would like to volunteer? Please contact the Channel Manager!


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Lowongan Kerja Marketing Manager
Finding the one individual who stands out from the rest, whose unique skills and qualifications make him or her the linchpin in a client's success, is the key to executive search. Our business at Universal Synergy – Executive Search Consultant is to find extra ordinary and talented people. We have built our executive search practice upon the belief that a company's leadership requirements are a critical part of its strategy, and that executive search is best performed with an undeniable commitment to the long-term success of our clients.
As a privately held company, we are driven by one objective: serving our clients. Our commitment to quality permeates through every element of our search: our people, our process and our database of proven and emerging talent.
Our Client, One or Leading Retail and Distribution Company with several leading foreign brands and wide distribution network through Indonesia is seeking suitable candidates to join their team as:
Marketing Manager (Electronic and Lighting)
Job Description:
Please kindly send us your resume to:
Universal Synergy – Executive Search Consultant
Email: email@example.com
Subject: Marketing Manager (Lighting) --- Update : Tuesday, October 20, 2009


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Bev Eggleston, the Virginia pig farmer trying to revive Ossabaw pigs, has refitted his truck to run on barbecue grease! He's struck up a symbiotic friendship with Hill Countrys Robbie Richter (Richter gets to try great pork, Bev gets to eat great barbecue), and the two have come to an understanding by which Richter will save his grease for Egglestons special diesel engine. The ideas not as crazy as it sounds: San Francisco asks restaurants to recycle grease for the city's bus fleet.
But Egglestons goal is more ethereal than environmental: My trip from Virginia to New York is six hours long, and Id like to make the whole thing on pork fat, Eggleston says. Im delivering pork, so I should be running on pork. That is crystalline logic at work. Egglestons Ossabaw hogs, meanwhile, are appearing on more and more New York menus: Aside from his original clients like Gramercy Tavern, Il Buco, and Blue Hill, his pigs will soon be making cameos at Insieme, Craftsteak, and other fine meateries.
Related: Virginia Pig Farmer Is the Toast of the New York Pork World


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To get away from the so-called "metropolitan elite" - who believe they run the country?
To get away from the so-called "metropolitan elite" - who believe they run the country?
The really important thing about this interesting little stat is...
... that we should remember all those people who so vehemently insisted that it would never happen.
These are the same people who have always insisted that immigration would either make no difference... and/or that immigration would improve things for those already here.
To put it nicely... these people are... at best... liars, dissemblers and fools.
They open-handedly give away that which does not belong to them... while all the time insisting that those who have a real claim to that which is given away... either did not want it.... did not deserve it... or that it actually belonged to the new owners in first place.
It was never about race... or "immigration"...
... it became "invasion" some considerable time ago... and the resources available to these small islands are now stretched to breaking point.
The future will not be pleasant for any of those crammed into what is clearly the designated benefit funded retail park of the European Union.
I fear that your "9%" comes under the heading of "... white British born will never be a minority in their own capital city... London".
Some of us have been aware for a long time of what the demographics of London had become.
People like you have been insisting for too long that we should not trust our own senses.
I'm not saying it's a necessarily bad thing... perhaps London needs annual riots... perhaps it will be good for the country... perhaps the world... as London becomes less and less functional... leading ultimately to a collapse of London property values.
But let's not worry about it. As long as we can all remain ever so ever so polite and not make any incomer feel unwelcome... it's bound to be for the best... and all in the best possible taste.
The English must be the first people in history to have committed national and cultural suicide... through "good manners".
Why fret about London... there are all those other towns and cities where the demographics are changing to suit the liars and thieves who have insisted that we should all smile while they give away that which does not belong to them... namely, our country, our heritage and our children's futures.
Except that they haven't committed any kind of "suicide". And good manners should be a matter of pride.The English must be the first people in history to have committed national and cultural suicide... through "good manners".
The answer to this question is quite simple....
....if you work on average wages, you cant afford London
but if you dont work, or are an imigrant on benefits you dont have to worry about escalating housing costs as they are paid for you.
"Don't go around saying the world owes you a living. The world owes you nothing. It was here first." Mark Twain
'white flight' out of London'.
Sounds like a racist comment or at least a comment to cause trouble.


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An aerial photograph, distributed by the Hamilton County Sheriff's Office, shows the crimson Jeep Rubicon belonging to Gail Palmgren. The Jeep and the human remains believed to be those of Palmgren were discovered Thursday on Signal Mountain.
Photo by Contributed Photo /Chattanooga Times Free Press .
published Friday, December 2nd, 2011
Stories this photo appears in:
The remains believed to be those of a missing 44-year-old woman were found Thursday afternoon and recovery efforts are beginning now.


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Comments from MainManJimmy
|Story title
|2011-04-11 08:08:18
|Jessica Loves Me?
|Thanks for the comments. I have posted chapter 2 now. But for some reason it hasn't linked with my profile as of yet. It's called "Jessica Loves me? 2" for those who you who want to read the next chapter.
|2011-04-13 05:02:34
|Jessica Loves Me? 2
|Thanks for comments guys. Spelling and grammar has always been a problem for me during my life and i aplogise for that.
On another note. I have just put chapter 3 up. Hope you guys enjoy it
|2011-04-27 17:41:10
|Jessica Loves Me? 3
|I appreciate each of your guys comments. Glad to see people are enjoying the story. 150 positive votes. Been on holiday at the beach and just got back but will write my next story in next couple days. Thanks again guys for reading and commenting
|2011-05-02 10:51:46
|Jessica Loves Me? 3
|Hey everyone. Just posted a new story called "Chuck: Deleted Scenes 1" for those who are interested. Took a beak from this story to write this new series and study for my exams coming up. I'll start writing the next chapter for this series now and it should be up by the end of the week.


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Search pictures and profiles of Senior Singles near you right now. Discover how online dating sites make finding singles in the United States, Canada, and all over the world simple, safe and fun! Once you browse profiles and pictures start flirting, messaging and connecting with other members of the SeniorPeopleMeet.com community. Search today and find other sexy, intelligent singles for casual dating or a serious relationship in your area.Search Single Senior Men | Search Single Senior Women
A little about me...
Hi ladies. I'm a fun loving guy who tans well. People say I'm a very handsome man with a great personallity. They say I look like a young Harrison Ford every bit as good looking as Tom Cruse. That's fine, but I'd rather be known for my integrity, wit, charm, skill with a fishing rod in my hands and my abillity on the ski slopes. I like outdoor activities, and quiet evenings at home with any film or a good espionage novel. When I have my camera repaired I'l upload a photo or two and you discerning ladies can evaluate for yourselves if what they say is true, Until then there is one question you need to ask yourself, do I feel lucky, well do ya!
About the one I'm looking for...
I like attractive ladies with a good sense of humor. Women who believe in themselves and are confident. A woman who is as comfortable in an evening dress as she is in her best pair of blue jeans. Ladies who can gleen as much satisfaction from being in a small boat on a big calm lake as they can from being on a crouded dance floor. I might be asking alot, but if I shoot for the stars I may just hit the moon, that wouldn't be so bad. I would hate to look back on my life filled with regrets waiting to meet oblivion alone.
I'd just like to add...
Send me a message.
Meet Senior Singles
in your State


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Aging, genetics, pregnancy and extreme weight loss are some of the factors that can cause the build-up of excess fat on different parts of your body such as your abdomen, thighs, hips and upper arms. To make matters worse, sometime these stubborn and unsightly fat deposits just won't go away – even if you diet and exercise. Liposuction, one of the most popular cosmetic surgery procedures in the world today, can help if you want a safe and effective solution to this problem. You can have Liposuction in Thailand done by highly skilled plastic surgeons at a safe, friendly and modern hospital environment.
Destination Beauty can help you get your ideal body shape back and we guarantee you world-class services at rates that are up to 70% lower than what you can get back home. We have partnered with the top hospitals and plastic surgeons in Bangkok and Phuket, and whether it's conventional Liposuction in Thailand, VASER Liposuction in Thailand, AccuSculpt Laser Lipolysis in Thailand or other liposuction techniques that you're looking for, we assure you of top-quality care. It's easy to get started – simply get in touch with us and learn more about Liposuction in Thailand and how we can help you for FREE!
Depending on your particular case and your surgeon's recommendation, there are several liposuction techniques that you can choose from.
Some of the types of liposuction available to you here in Thailand include:
In the cosmopolitan capital city of Bangkok, our partner hospitals offer conventional liposuction in Bangkok, VASER Liposuction in Bangkok and AccuSculpt Laser Lipo in Bangkok techniques. And in the postcard-perfect island of Phuket, you can opt for either conventional Liposuction in Phuket or VASER Lipo in Phuket. Whatever destination you choose, though, you're sure to be under the care of competent, English-speaking surgeons who are backed by highly trained and compassionate medical professionals.
If liposuction sounds like the answer to your problems and don't know where or how to begin, we'll gladly help you – for FREE!
That's right. When you contact us by filling out the form on this page or emailing us at email@example.com, we'll get back to you with answers to your questions and more information about the different Liposuction techniques in Thailand as well as with detailed info on our partner surgeons and hospitals. We'll also – at your convenience – walk you through a FREE online consultation with a real Thai surgeon.
When you decide to fly over to have your procedure done in Thailand, we'll work with you with all the bookings – from your airlines to your hotels to your hospital. Once you touch down in Bangkok or Phuket, we'll make sure you always have someone to turn to if you have some more questions or concerns.
Of course, a smooth experience with results you've been hoping for – that's what you want. So, we'll make sure that all your bookings stay on track and we'll help you with advice and counseling while you rest and recover.
So, if you want to get rid of your excess fat, you first have to get rid of your anxieties and doubts. Get in touch with us now and let us work with you to have Liposuction in Thailand!


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Cusano P1 CigarsView Samplers of Cigars
Cusano P1 Cigars Description
Cusano P1 cigars are handmade with a well-balanced blend of long & short premium-grade Dominican tobaccos rolled in a handsome U.S. Connecticut Broadleaf Maduro wrapper that's lighter in color than most Maduros. Medium-bodied with a naturally sweet tobacco flavor, the P1 blossoms into an impressive full-flavored and complex smoke with a great aroma. Presented in bundles of 20 cigars, this cigar is a consistently good performer, and makes a terrific alternative to Partagas and Punch.
Buy Cusano P1 Cigars online at discount prices here at Famous Smoke Shop - your source for Cusano P1 Cigars.
Other Brands by Cusano
Customer Reviews
by Domrey Cigar Limited
by Matasa
by Rocky Patel Cigars


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Financial Information
Seed Savers Exchange is a non-profit, 501(c)(3), member supported organization, and your contributions are tax deductible to the extent allowed by the law. We are focused on making the best use of every dollar donated to the SSE mission. Click here to read about our programs which are funded by your contributions.
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HarbourKids: Thanksgiving
This event has passed.
- Date:
- Category:
- Location
Let's Create and Appreciate!
Bring the kids to a world of good at Harbourfront Centre this Thanksgiving Monday. Featuring a full day of family fun, including concerts, films, crafts and more. We're putting the "great" back in grateful.
For more details: www.harbourfrontcentre.com/harbourkids
Location: Harboufront Centre


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The pilot was landing on runway 36, a 3,000-foot-long, 50-foot-wide, asphalt runway. The airplane touched down on the left side of the runway centerline and bounced. The airplane touched down again; however, the left landing gear was off the runway surface and the airplane was drifting further to the left. The airplane struck a runway edge light and the pilot attempted to abort the landing; however, the airplane struck a second runway light, became airborne, and then impacted trees, before coming to rest. Winds reported at an airport located about 8 miles northwest of the accident site, about 20 minutes prior to the accident, were from 290 degrees at 16 knots, gusting to 26 knots. The pilot did not report any mechanical failures or malfunctions of the airplane.
The National Transportation Safety Board determines the probable cause(s) of this accident to be:
Index for Nov2008 | Index of months


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From Proteopedia
|2xwr, resolution 1.68Å ()
|2biq, 1dt7, 2ybg, 2j1x, 1uol, 2foj, 2b3g, 2bin, 1olh, 1pes, 1tsr, 2j21, 2gs0, 2j0z, 1c26, 2x0v, 1sal, 1kzy, 1xqh, 2fej, 2ahi, 1a1u, 3sak, 2wgx, 1saf, 2foo, 2bio, 1olg, 2j11, 2bip, 1pet, 1jsp, 2j1y, 1ma3, 2x0w, 2vuk, 1aie, 2h1l, 1saj, 1tup, 1hs5, 2x0u, 2ata, 1ycq, 1gzh, 1sah, 1ycr, 2bim, 2j10, 1sak, 2ady, 1sae, 2j1z, 1ycs, 2ac0, 2j20, 1h26, 2j1w
|FirstGlance, OCA, RCSB, PDBsum
|save as pdb, mmCIF, xml
The tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle and provides a paradigm for an emerging class of oligomeric, multidomain proteins with structured and intrinsically disordered regions. Many of its biophysical and functional properties have been extrapolated from truncated variants, yet the exact structural and functional role of certain segments of the protein is unclear. We found from NMR and X-ray crystallography that the DNA-binding domain (DBD) of human p53, usually defined as residues 94-292, extends beyond these domain boundaries. Trp91, in the hinge region between the disordered proline-rich N-terminal domain and the DBD, folds back onto the latter and has a cation-pi interaction with Arg174. These additional interactions increase the melting temperature of the DBD by up to 2 degrees C and inhibit aggregation of the p53 tetramer. They also modulate the dissociation of the p53 tetramer. The absence of the Trp91/Arg174 packing presumably allows nonnative DBD-DBD interactions that both nucleate aggregation and stabilize the interface. These data have important implications for studies of multidomain proteins in general, highlighting the fact that weak ordered-disordered domain interactions can modulate the properties of proteins of complex structure.
Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer., Natan E, Baloglu C, Pagel K, Freund SM, Morgner N, Robinson CV, Fersht AR, Joerger AC, J Mol Biol. 2011 Jun 10;409(3):358-68. Epub 2011 Mar 30. PMID:21457718
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
[P53_HUMAN] Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma. Defects in TP53 are a cause of esophageal cancer (ESCR) [MIM:133239]. Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is an autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.[1][2][3][4][5][6][7][8][9][10] Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. Defects in TP53 are a cause of lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Defects in TP53 are a cause of choroid plexus papilloma (CPLPA) [MIM:260500]. Choroid plexus papilloma is a slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood.[11] Defects in TP53 are a cause of adrenocortical carcinoma (ADCC) [MIM:202300]. ADCC is a rare childhood tumor of the adrenal cortex. It occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome and is a component tumor in Li-Fraumeni syndrome.[12] Defects in TP53 are the cause of susceptibility to basal cell carcinoma 7 (BCC7) [MIM:614740]. A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.[13]
[P53_HUMAN] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; te function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.[14][15][16][17][18][19][20][21][22][23][24]
About this Structure
2xwr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
- Natan E, Baloglu C, Pagel K, Freund SM, Morgner N, Robinson CV, Fersht AR, Joerger AC. Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer. J Mol Biol. 2011 Jun 10;409(3):358-68. Epub 2011 Mar 30. PMID:21457718 doi:10.1016/j.jmb.2011.03.047
- ↑ Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13777-82. PMID:10570149
- ↑ Law JC, Strong LC, Chidambaram A, Ferrell RE. A germ line mutation in exon 5 of the p53 gene in an extended cancer family. Cancer Res. 1991 Dec 1;51(23 Pt 1):6385-7. PMID:1933902
- ↑ Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA, et al.. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990 Nov 30;250(4985):1233-8. PMID:1978757
- ↑ Srivastava S, Zou ZQ, Pirollo K, Blattner W, Chang EH. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature. 1990 Dec 20-27;348(6303):747-9. PMID:2259385 doi:http://dx.doi.org/10.1038/348747a0
- ↑ Felix CA, Nau MM, Takahashi T, Mitsudomi T, Chiba I, Poplack DG, Reaman GH, Cole DE, Letterio JJ, Whang-Peng J, et al.. Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia. J Clin Invest. 1992 Feb;89(2):640-7. PMID:1737852 doi:http://dx.doi.org/10.1172/JCI115630
- ↑ Malkin D, Jolly KW, Barbier N, Look AT, Friend SH, Gebhardt MC, Andersen TI, Borresen AL, Li FP, Garber J, et al.. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J Med. 1992 May 14;326(20):1309-15. PMID:1565144 doi:http://dx.doi.org/10.1056/NEJM199205143262002
- ↑ Frebourg T, Barbier N, Yan YX, Garber JE, Dreyfus M, Fraumeni J Jr, Li FP, Friend SH. Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome. Am J Hum Genet. 1995 Mar;56(3):608-15. PMID:7887414
- ↑ Varley JM, McGown G, Thorncroft M, Tricker KJ, Teare MD, Santibanez-Koref MF, Martin J, Birch JM, Evans DG. An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53. J Med Genet. 1995 Dec;32(12):942-5. PMID:8825920
- ↑ Luca JW, Strong LC, Hansen MF. A germline missense mutation R337C in exon 10 of the human p53 gene. Hum Mutat. 1998;Suppl 1:S58-61. PMID:9452042
- ↑ Guran S, Tunca Y, Imirzalioglu N. Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family. Cancer Genet Cytogenet. 1999 Sep;113(2):145-51. PMID:10484981
- ↑ Rutherford J, Chu CE, Duddy PM, Charlton RS, Chumas P, Taylor GR, Lu X, Barnes DM, Camplejohn RS. Investigations on a clinically and functionally unusual and novel germline p53 mutation. Br J Cancer. 2002 May 20;86(10):1592-6. PMID:12085209 doi:10.1038/sj.bjc.6600269
- ↑ Ribeiro RC, Sandrini F, Figueiredo B, Zambetti GP, Michalkiewicz E, Lafferty AR, DeLacerda L, Rabin M, Cadwell C, Sampaio G, Cat I, Stratakis CA, Sandrini R. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9330-5. PMID:11481490 doi:10.1073/pnas.161479898
- ↑ Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexo BA, Tjonneland A, Overvad K, Rudnai P, Gurzau E, Koppova K, Hemminki K, Corredera C, Fuentelsaz V, Grasa P, Navarrete S, Fuertes F, Garcia-Prats MD, Sanambrosio E, Panadero A, De Juan A, Garcia A, Rivera F, Planelles D, Soriano V, Requena C, Aben KK, van Rossum MM, Cremers RG, van Oort IM, van Spronsen DJ, Schalken JA, Peters WH, Helfand BT, Donovan JL, Hamdy FC, Badescu D, Codreanu O, Jinga M, Csiki IE, Constantinescu V, Badea P, Mates IN, Dinu DE, Constantin A, Mates D, Kristjansdottir S, Agnarsson BA, Jonsson E, Barkardottir RB, Einarsson GV, Sigurdsson F, Moller PH, Stefansson T, Valdimarsson T, Johannsson OT, Sigurdsson H, Jonsson T, Jonasson JG, Tryggvadottir L, Rice T, Hansen HM, Xiao Y, Lachance DH, O Neill BP, Kosel ML, Decker PA, Thorleifsson G, Johannsdottir H, Helgadottir HT, Sigurdsson A, Steinthorsdottir V, Lindblom A, Sandler RS, Keku TO, Banasik K, Jorgensen T, Witte DR, Hansen T, Pedersen O, Jinga V, Neal DE, Catalona WJ, Wrensch M, Wiencke J, Jenkins RB, Nagore E, Vogel U, Kiemeney LA, Kumar R, Mayordomo JI, Olafsson JH, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet. 2011 Sep 25;43(11):1098-103. doi: 10.1038/ng.926. PMID:21946351 doi:10.1038/ng.926
- ↑ Schneider E, Montenarh M, Wagner P. Regulation of CAK kinase activity by p53. Oncogene. 1998 Nov 26;17(21):2733-41. PMID:9840937 doi:10.1038/sj.onc.1202504
- ↑ Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP. The function of PML in p53-dependent apoptosis. Nat Cell Biol. 2000 Oct;2(10):730-6. PMID:11025664 doi:10.1038/35036365
- ↑ Louria-Hayon I, Grossman T, Sionov RV, Alsheich O, Pandolfi PP, Haupt Y. The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem. 2003 Aug 29;278(35):33134-41. Epub 2003 Jun 16. PMID:12810724 doi:10.1074/jbc.M301264200
- ↑ An W, Kim J, Roeder RG. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004 Jun 11;117(6):735-48. PMID:15186775 doi:10.1016/j.cell.2004.05.009
- ↑ Ghosh A, Stewart D, Matlashewski G. Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol. 2004 Sep;24(18):7987-97. PMID:15340061 doi:10.1128/MCB.24.18.7987-7997.2004
- ↑ Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V. The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem. 2007 Apr 20;282(16):11969-81. Epub 2007 Feb 22. PMID:17317671 doi:M608974200
- ↑ Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell. 2007 Mar 9;25(5):725-38. PMID:17349958 doi:10.1016/j.molcel.2007.02.007
- ↑ Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11612-6. doi:, 10.1073/pnas.0813177106. Epub 2009 Jun 25. PMID:19556538 doi:10.1073/pnas.0813177106
- ↑ Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010 Aug 6;142(3):409-19. doi: 10.1016/j.cell.2010.06.040. PMID:20673990 doi:10.1016/j.cell.2010.06.040
- ↑ Wu L, Ma CA, Zhao Y, Jain A. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem. 2011 Jan 21;286(3):2236-44. doi: 10.1074/jbc.M110.174755. Epub 2010 , Oct 19. PMID:20959462 doi:10.1074/jbc.M110.174755
- ↑ Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM. p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell. 2012 Jun 22;149(7):1536-48. doi: 10.1016/j.cell.2012.05.014. PMID:22726440 doi:10.1016/j.cell.2012.05.014


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6′ 5″ 345 • Offensive Tackle • Georgia
Comparison: Carl Nicks
Grade 7.8 ¦ About the Grade
- Amazing raw strength
- Will drive defenders off the screen
- Quick and nimble feet
- Plays aggressively and with a mean streak
- Plays well in smaller areas
- Shows good agility getting to the second level and laterally
- Adjust well
- Can swallow up bull rushers
- Long arms
- Can play multiple positions along the line
- Overall technique needs to be corrected
- Doesn't bend properly
- Gets to tall in the run game
- Fires off the ball recklessly missing blocks
- Struggles in space
MockDraft 101′s Opinion:
- I'm beginning to warm up towards Cordy Glenn, he struggled early in the season and looked more like a second round guard. As the season wore on he got stronger and looked like he could play OT at the next level. His combine performance answered any doubts I had about him athletically and I moved him from my Guard to OT list. Glenn has a high upside and all of his weaknesses can be corrected with good coaching. Not sure he can be a franchise LT, but no doubt has the skill set to be a solid RT for a team towards the bottom of Round 1.


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Girls Track
Spring Track practice @ track - 2:30
Mansfield's results for the MSTCA Twilight Meet at Barnstable Fair Grounds on October 19th:
38. 12 Sami Carey 19:24.2
45. 9 Julie Romano 19:35.2
55. 11 Emily Sarkisian 19:45.7
78. 11 Morgan Debolt 20:20.7
139. 12 Sarah Neenan 21:43.0
145. 11 Sarah Fernandez 21:51.9
Mansfield placed 13th overall in the meet.
Information from Coach Ellis
Reported by Brian Carchedi
The Girls Cross Country team finished off the dual meet season with a perfect 5-0 record. That gives the team the Kelly Rex Division Dual Meet title. This is the first time in about a decade that Mansfield girls have won it. Coach Ellis: "These girls have been working very hard all season and its great to see them come together and accomplish an undefeated season."
Information from Coach Ellis
Reported by Brian Carchedi
On Tuesday, October 1st, Mansfield beat KP 27-30. Mansfield took 2nd, 3rd and 4th in the race, which put the hornets in a good position. It then came down to Morgan Debolt, who was battling four KP runners. She secured sixth place with a PR time, which secured the race for the team.
The team is now 4-0 which guarnatees a share of the Kelly Rex Dual Meet Title. The team will race Taunton next tuesday.
Information from Coach Ellis
Reported by Brian Carchedi
Mansfield Results at the Ocean State Invitational at Goddard Park in Warwick, RI
Large School Varsity Race
Team Placed 10th with 237 Points
15 Sami Carey 20:15.15
31 Emily Sarkisian 20:44.19
46 Morgan DeBolt 21:17.30
76 Kerri Sullivan 22:15.14
86 Sarah Neenan 22:29.76
97 Sarah Fernandez 22:50.77
110 Grace Parsons 23:21.95
Large School Junior Varsity
One Mansfield girl earned a medal
28 Sophie Kelliher 22:20.11
Large School Freshman Race
The freshman Team came in 4th overall with 89 Points
2 Julie Romano 16:08.23
21 Kerry McCarthy 17:56.97
36 Jessica Cowan 19:02.43
42 Emily Aarons 19:26.42
55 Nicole Mackie 20:25.95
Information from Coach Ellis
Reported by Brian Carchedi
On Tuesday, September 10th, Sami Carey and Emily Sarkisian led the Mansfield squad to a 15-46 win over Attleboro. Mansfield would take the top 5 spots in the race. Freshman Julie Romano ran to an impressive 3rd place finish in a time of 20:11. Morgan DeBolt and Sarah Neenan would round out the scoring for Mansfield.
Mansfield's next meet is home against North Attleboro on Tuesday.
Information from Coach Ellis
Reported by Brian Carchedi


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Written by Lyn Dobrin, firstname.lastname@example.com Wednesday, 24 April 2013 08:44
Don't speak Portuguese? Here's a little vocabulary lesson to explain the name of this family-style restaurant.
Brasa — hot coal that is ready for roasting.
Churrasqueira — a restaurant serving wood-char grilled meat; servers come to the table with meat on a skewer.
Rodizio — a style of service, where diners pay a fixed price and waiters bring food several times during the meal until the diner says "Enough!"
In this Portuguese-style all-you-can-eat restaurant, waiters bring skewers of grilled meat to the table and you select what you want: pork loin, skirt steak, top sirloin, beef cubes, beef ribs, chicken, chicken drumsticks, turkey with bacon and Brazilian sausage. When you've had enough, you just say "no" when the skewers are brought around.
Or you can order individual dishes from the menu. Brasa is rightfully proud of its chicken, a two-and-one-half pound fryer, butterflied, seasoned with sea salt and other spices, and basted as it cooks over the hot charcoal fire. The skin is crispy and a bit spicy. The meat, particularly the leg and thigh, is tender. If you want to go spicier, ask for their piri piri sauce with red pepper flakes and oil.
In addition to the meats, Brasa serves soups, hot sandwiches and fish dishes that include grilled cod fish, grilled swordfish and branzino, all served family-style with an assortment of carbs: white rice, French fries, boiled potato, delicious house-made potato chips, plus steamed vegetables. All diners get the cold and vinegary house salad of lettuce, onions and tomatoes, plus olives and bread. Extra sides are black beans, fried bananas, sautéed collard greens and farofa (toasted cassava flour).
There are two lunch specials every day. A recent offering was grilled octopus with red skinned potatoes, roasted red pepper and onions, and alentesana — pork, clams and potatoes with cilantro, one of the most traditional and popular pork dishes in Portuguese cuisine.
Most desserts are made in-house and include flan, heavenly whites (a rich pudding of heavy cream, eggs and Marie tea biscuits) and pistachio cake.
A few words about that pistachio cake. When co-owner Paul Batista told me the most popular dessert at Brasa was a pistachio cake, I thought I'd hear that it had been passed down from generation to generation from his ancestors in Portugal. Instead, I learned that he had invented the cake, modifying a recipe that his Italian mother-in-law had located, and that one of the prime ingredients was white cake mix.
The recipe for Brasa's pistachio cake feels a bit like the Food Network's "Chopped" where chefs are given a box of ingredients to make a dish. In addition to the white cake mix, there's also pistachio pudding mix, Sprite soda and pistachios.
The cake is very moist — almost like a thick pudding. The chopped pistachios add a welcome crunch in the icing. This is the kind of dessert that can easily become a craving.
Brasa Churrasqueira Rodizio is located at 100 Herricks Road in Mineola. The phone number is 516-280-8000; the website, www.brasarodizio.com.


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WILDCARE Tasmanian Coast Conservation Fund
Click here to donate to WILDCARE Tasmanian Coast Conservation Fund
The WILDCARE Tasmanian Coast Conservation Fund has been established in partnership with Pennicott Wilderness Journeys to contribute towards the protection, conservation and management of marine and coastal reserves, marine mammals and seabirds.
The fund supports projects dealing with one or more of the following themes:
- coastal reserve and marine reserve management
- marine mammal and seabird conservation
- community awareness of and participation in coastal and marine conservation
If you would like to support the conservation of Tasmania's spectacular coastline and the wildlife that lives there, make a tax deductible donation today, either here on line or by post to WILDCARE Inc GPO Box 1751 Hobart 7001 Tasmania Australia. Cheques should be made out to WILDCARE Tasmanian Coast Conservation Fund. All donations of $2 or more are tax deductible.
WILDCARE Inc thanks Pennicott Wilderness Journeys for their partnership in establishing this fund with WILDCARE Inc and for their support of reserve management and wildlife conservation.
You can help us build on their initiative and on-going commitment by donating to the fund.
What has the fund done to date?
Tasman Island pest eradication program success
WILDCARE Inc is pleased to announce that Tasman Island has been declared cat-free, following the success of a program to eradicate the feral pests that have wreaked havoc on the island's populations of ground-nesting seabirds.
Rangers from the Parks and Wildlife Service and scientific staff from the Department of Primary Industries, Parks, Water and Environment have monitored the island regularly since the establishment in 2009 of the eradication program, funded by the Wildcare Tasmania Coast Conservation Fund which has been strongly supported by ecotourism operator Pennicott Wilderness Journeys.
A final check of the 120-hectare island recently found no sign of feral cats and the island has been declared free from the predators, which were killing an estimated 50,000 birds every year.
Rob Pennicott says that he and his staff are thrilled to have been able to support the Tasman Island initiative through a $65,000 donation to the Wildcare Tasmanian Coast Conservation Fund.
"It's great to know that we've played a part in saving tens of thousands of fairy prions, short-tailed shearwaters and other seabirds that breed on Tasman Island," Rob says. "These wonderful native birds will now increase in numbers, free from the threat of predatory felines."
Rob paid tribute to the Parks and Wildlife Service staff who carried out the preliminary research, worked on the field activities and conducted the follow-up monitoring of the program.
"It's been a true team effort between Parks and Wildlife, Wildcare Inc and the Tasmanian Coast Conservation Fund," he says. "Everyone involved with Pennicott Wilderness Journeys feels great satisfaction at seeing this program achieve success. And every day, as our boats pass close to the island's rugged sea crags, it's great to be able to explain to our guests that they have played a role in the program's success, because a proportion of every ticket goes to help the work of the Fund."
Parks and Wildlife Service Tasmania is the Agency responsible for managing the conservation reserve estate in Tasmania – land amounting to 39% of Tasmania, in excess of 440 reserves including 19 National Parks and the globally significant Tasmanian Wilderness World Heritage Area. WILDCARE Inc has a long standing, positive and productive partnership with the Parks and Wildlife Service to protect and manage Tasmania's reserved land, and conserve Tasmania's natural and cultural heritage.
Pennicott Wilderness Journeys are leaders in marine eco-tourism and operate along the coastlines of the Tasman Peninsula and Bruny Island. Rob Pennicott and his team encourages other marine tourism operators to contribute to the Tasmanian Coast Conservation Fund to support protection, conservation and management of our coasts and the wildlife that lives there. To date (2010) Rob Pennicott has donated $100,000 to the Wildcare Tasmania Coast Conservation Fund.


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GAINESVILLE -- Florida center Dwayne Schintzius helped dispel rumors that he will turn pro after this season by saying Wednesday that he has taken out a $1 million insurance policy through next season.
Some NBA scouts have said Schintzius, a 7-foot-2 junior, would be a lottery pick in this year`s NBA draft should he turn pro. Although he has denied any desire to leave Florida early, rumors persisted about Schintzius` intentions.