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Providing the latest business, scientific, and regulatory news for the pharmaceutical and biotech industries.
News from Europe's pharmaceutical manufacturing industry coupled with upcoming events, and exclusive articles and interviews from industry experts.
Can Pharma Defy Gravity at the Patent Cliff?
Generic-drug competition has become increasingly aggressive, especially in an environment where healthcare policies are placing stronger emphasis on pharmacoeconomics and demanding better treatment outcomes at a lower cost. A 2012 analysis by IMS Health estimated that patent expiries will reduce brand spending in developed markets by $127 billion through 2016 (1). With drug-development expenditures escalating at an alarming rate while R&D productivity continues to decline, branded drug-makers are under pressure to maximize the value of their products throughout their lifecycles.
"Although the development of new drugs to address unmet patient needs remains the single most important goal of any pharmaceutical company, effective lifecycle management (LCM) is invaluable for getting the greatest possible value from existing brands," says Anil Kane, PhD, executive director and global head of formulation sciences, Patheon.
"The challenge, however, is in the development of creative and unique strategies that will generate intellectual property and provide additional mid- to long-term exclusivity for the product," notes Ninad Deshpanday, PhD, president, R&D, Cirrus Pharmaceuticals, a Kemwell company. "The competition among innovators developing similar strategies has increased, and generics have become smarter; therefore, the window to succeed with novel lifecycle products has become much narrower today."
LCM strategies include identifying new indications, developing modified formulations, finding new routes of administration, combining more than one drug into a single product, producing the drug as a single enantiomer if the original drug substance was a racemic mixture, and switching from a prescription product to over-the-counter (OTC) status, among others. According to Kane, the key issue facing pharmaceutical companies is the selection of one or more of these LCM options by understanding the opportunities and competitor landscape, potential return on investment, and the ability of timely implementation. "Adopting a proactive LCM strategy, such as line extension into pediatrics, changing the dosing regimen by using modified-release formulations or improving clinical benefits and patient compliance by combination products, can offer a broad patent coverage and enhance the value of the brand," Kane adds.
Thomas Hein, PhD, director of sales & business development, at Hermes Pharma, emphasizes that LCM should start as early as possible and be part of an overall product portfolio strategy. "However, from our experience, most companies tend to consider line extensions after the product has been marketed for several years with the aim of prolonging the product lifecycle when it is under threat or when looking to target new customer segments such as children or the elderly."
Formulation strategies
"Expand-and-grow formulations seek to unlock either new or unsatisfied patient pools that are not well addressed by available market formulations. As such, these approaches are already well differentiated from the original, generic-threatened formulations, and therefore, have a degree of competitive protection although such approaches offer no protection to the mass-market side of the business," continues Hansen. "Classic examples of this approach include pediatric and geriatric formulations, fast-melts for 'on-the-go' patients, and intravenous/intramuscular forms for acute use in hospitals."
Modified-release formulations
A well-known case is with Pfizer's cardiovascular drug, Procardia (nifedipine), when it lost its patent. Pfizer went on to introduce Procardia XL, an extended-release formulation designed for once-daily administration as opposed to three times a day with the conventional tablet. The improved formulation consists of a semipermeable membrane surrounding an osmotically active drug core. The drug core is divided into two layers: an active layer containing the drug and a push layer containing osmotically active but pharmacologically inert components. Once ingested, water enters the tablet and the increased pressure in the osmotic layer pushes against the drug layer, releasing the drug through a laser-drilled orifice at a constant rate over 24 hours (2).
Another LCM example is Bristol-Myers Squibb's extended-release formulation of its oral antihyperglycemic drug, Glucophage XR (metformin), which permitted once-daily dosing (instead of twice-daily) in the management of Type II diabetes. Glucophage XR consists of a dual hydrophilic polymer matrix system. Metformin is combined with a polymer, which controls drug release, to form an inner phase. This inner phase is then incorporated as discrete particles into an external phase of a second polymer. Following administration, gastrointestinal fluids enter the tablet, causing the polymers to hydrate and swell, thereby releasing the drug slowly by diffusion through the gel matrix. Drug release is independent of pH, and the hydrated polymer system is broken down by peristalsis of the gastrointestinal tract (3).
Similarly, after the patent of Eli Lilly's blockbuster antidepressant drug, Prozac (fluoxetine), expired, the company developed a once-weekly sustained-release formulation. Prozac Weekly capsules contain enteric-coated pellets that resist dissolution until the lower region of the gastrointestinal tract where the pH is more than 5.5. The enteric coating delays the onset of absorption of fluoxetine for 1 to 2 hours compared with the immediate-release formulations (4). Compliance with the weekly formulation was better than with once-daily fluoxetine (5).
Janssen Pharmaceuticals also used modified-release formulations to optimize product lifecycle by introducing a once-daily paliperidone palmitate tablet (Invega) and an extended-release injectable suspension for intramuscular use (Invega Sustena), administered once every four weeks, for the treatment of schizophrenia. Invega Sustena incorporates Alkermes' proprietary technology for nanoparticles. Janssen is now developing a three-month depot injection, and in June 2012, the company initiated a Phase III trial to evaluate the efficacy, safety, and tolerability of the three-month formulation (6).
Combination products
For example, Eli Lilly launched Symbyax (olanzapine and fluoxetine) as a means to stall sales erosion following the patent expiry of its antipsychotic blockbuster, Zyprexa (olanzapine). Merck & Co. also pursued this strategy with the development of Fosamax Plus, which is a combination of a bisphosphonate and vitamin D for the treatment of osteoporosis in postmenopausal women, and Juvisync, the FDC formulation of the cholesterol-lowering agent, simvastatin, and the antidiabetic drug, sitagliptin. Other examples include GlaxoSmithKline's combination treatments for HIV, Combivir (lamivudine and zidovudine), Trizivir (abacavir, lamivudine, and zidovudine), and Epzicom (abacavir and lamivudine); and Gilead's Truvada (tenofovir and emtricitabine).
FDCs can be developed in different forms, for example, layered tablets, hard gelatin capsules filled with multiple products or multiparticulate tablets, formed through the compression of multiparticulates. In terms of formulation considerations for FDCs, Barzanti explained that the first issue is the challenge of bringing together different pharmacokinectics and target release profiles, which becomes more complex with higher number of actives. "From the manufacturing point of view, however, one of the most common challenges is combining two chemically incompatible actives that need to be kept separated but included in a single dosage form," says Barzanti. "This issue is particularly crucial for layered tablets, where sometimes, an
Another critical issue for all forms of FDC is the in-line control of the single dosages of each drug. "In a layered tablet, the single layers can be sampled and checked individually but it is not possible to check them separately in the final complete unit dose," notes Barzanti. "On the contrary, manufacturing of FDC in hard gelatin capsules can be easily achieved through subsequent filling unit, and many technical solutions are available for in-line check of each drug dosage."
Fast-dissolve formulations
"Applications of fast-dissolve formulations are expanding across therapeutic areas," observes Steve Hamlen, global group product manager, Catalent. For example, conventional selegiline tablets had to be taken more than once daily. Not only did the conventional formulation have less than optimal efficacy, but it also presented a safety risk due to first-pass metabolite formation. The fast-dissolve formulation of selegiline, Zelapar, developed using Catalent's Zydis orally disintegrating tablet technology, is absorbed buccally, thereby, avoiding first-pass metabolism and significantly reducing the potential for side effects. The ability to disintegrate in less than 3 seconds allows for increased bioavailability and a faster onset of action for Zelapar. The maximum blood levels of the drug (Tmax) were achieved in 15 minutes for Zelapar compared with 1 hour for the conventional selegiline pills. Moreover, dosing frequency could be reduced (i.e., 1.25 mg or 2.5 mg once daily compared with 5 mg twice daily for the conventional formulation).
"In one recent case, we were asked to redesign a life-saving medication that required delivering large quantities of the API. The original medication is administered as multiple tablets taken three times a day," says Hein. "We reformulated the medicine from a series of solid tablets into three single packages of orally disintegrating granules, allowing us to encapsulate more API per dose, and therefore, simplify the treatment regimen. This innovation not only improved patient compliance but also provided our client with the opportunity to extend patent protection as the new formulation significantly improved the product."


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Blast bridges, towers and vehicles with dynamite.You need to place the dynamite in the right places to complete mission. Try to complete all 30 levels.
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"Shadow of the Colossus", a game released by the SCEI, the developers of ICO. A completely original game which involves beautiful imagery, amazing landscapes, gorgeous visuals, and heart-racing action as you take down sixteen giant colossal beasts one after another.
SotC should of been Game of the Year 2005.
by Christerray January 25, 2006


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INTERNET EXPLORER PROBLEMSIf you experience problems on this web site, that the drop down menus no longer works or pictures don't show, please turn on the "Compatibility views" (Tools - Compatibility views).


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Leather wearers. Must have gone too fast without me picking up on it. Mah bad!
Am I reading this right? For the example of an elemental shaman, you could spec elemental (chuck bolts, LBs, thunderstorm, etc), but talent resto and enhance? Sure, that would probably suck for raiders by lowering their potential output, especially the Paragon types that min/max everything to death. But it sounds awesome... in theory. It's interesting enough that I'll definitely wanna see the next xpac, but so vastly limited (1 point per 15 levels?) that it's a little unsettling. Also, the builds are likely to be even more cookie-cutter than in the past if my understanding is correct.
Re: Pandaren racials. Bouncy and Inner Peace (50% damage reduction BETTER be on a CD! Double-duration rested XP) seem a little OP, ESPECIALLY the double-duration rested XP. Why create a lush new environment then allow players to smash through it double-fast without caring?
Monks Armor: I presume they'll be cloth wearing types? MAYBE leather at the heaviest? Has there been any mention?
I'm way better at holding my liquor than a panda.
Leather wearers. Must have gone too fast without me picking up on it. Mah bad!
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I suppose that fits from a gearing standpoint. Other than mail, that has three classes fighting over drops at every armor level which leads me to believe the next class introduced will be a mail user.
I'm way better at holding my liquor than a panda.
You'll prolly see them be an agility class most likely. Agi/Int not out of the question.
Actually...gods, it has a tank spec. I have no idea anymore. It'll prolly be like...druid style.
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"Damnit!" - Jack Bauer, 24
We are now officially DONE Day 1. I would like to thank people to have come visit the site hope that you will come tomorrow for a whole bunch more information!
And this time without me disappearing for one panel and making the info NOT come in on time. Apologies!
Hope you enjoyed!
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I'm watching via live virtual ticket too!
Druid style makes sense if they're wearing leather. Otherwise there's itemization issues out the ass, and creating a new "purple shirt of the ___" type thing for just one class sounds utterly ridiculous. Should be an interesting tank class with no auto-attack. I'm VERY interested in seeing their AoE abilities. How does their Chi bar work? Like rage/rp, or more like CP?
I'm way better at holding my liquor than a panda.
The class wasn't really spoken about 'that' much so we have no idea what the info will come out. might be Day 2. Who knows.
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"Damnit!" - Jack Bauer, 24
Might just be a mystery until beta. HOWEVER.. I do like that Blizzard has been listening to player suggestions about the next class added! I've seen many, many posts about people wanting a monk class. I'll definitely be testing it out myself once it goes live. Not even gonna try for the beta.
I'm way better at holding my liquor than a panda.
They already stated exactly what Pandas will wear: Agility leather for Tank/Melee DPS, and Int Leather for healing. They will basically gear up exactly like Druids do now.
They also stated Pandas will use Staves (i.e. Agility ones for tanking/DPS just like Bears/Cats do now) and 1h Swords/Maces/Fist Weaps (i.e. Caster gear for Healing, and potentially Rogue/Enh Shaman weapons if dual-wielding is in, which I bet it will be) as being usable.
pandas? really? what next hello kitty? how about seseme strees and make it educational for tots, pathetic bliz, whats the panda racial? bonus to gold-farming? summon tanks to take out mob crowds? bliz should not be glorifying this part of the world, that stupid pet for tsunami was bad enough... think they sold anything to help katrina vics? wish i liked star wars but i do not, but this is pathetic!
http://www.worldofwarcraft.com/annualpass gives guaranteed beta access. And its able to be paid for in installments.
1) it's not the d3 beta, it's the frigging full release game (get facts straight please)
2) the beta is for Mist of Pandaria
3) it's added benefit for people who planned on playing anyways who are willing to accept the fact that they'll still be subbed for a year.
The way I see it, those who know they'll still be subbed, get bonuses now for just subbing 1 year early and committing. Any of you who are "quitting soon, or burnt out" this isn't your option, don't buy the annual pass. Buy D3 for your 60 bucks, and it'll be cheaper for you. I fail to see how this is "downhill" or "a cheap shot". Seriously people are finding reasons to hate on blizzard when they're doing something that in my opinion is a great alternative to choosing between the two games. But hey, that's your perogative, but don't state shit incorrectly, and then try to blame blizzard for doing something that makes sense.
Zomg, a company wants to make profits!
@people hating on Pandarens, did any of you =play warcraft 3: TFT? Pandarens existed in the Lore. Whether you like it or not, they did, and this should've come as no surprise. "blood elves on horde? Really" who remembers those comments, now no one gives a shit. grow up. Making allusions to hello kitty. seriously? You're playing a GAME WITH ORCS, ELVES, DWARVES, GOBLINS, and GNOMES. Chinese Panda-men, that's too far, space goats? TOTALLY ACCEPTABLE. get off your high horse. At least Pandarens were part of the former warcraft lore with Pandaren brewmasters, Space goats were out of left field, more so than the werewolves.
Last edited by Kazeyonoma; 10-24-2011 at 11:13 AM.
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one word: pokemon
|Ex Tank|
Kren, you can add this to your post if you want in the bottom:
Starcraft 2 Changes
For the full list, please check out Teamliquid's thread: http://www.teamliquid.net/forum/view...opic_id=277762
-Thor is now a final tier unit (only have 1, similar to mothership), has aoe stun/damage spell now, and requires fusion core to build from a tech lab'd factory
-NEW UNIT: Warhound - basically thor anti-air of past + goliath like ground attacks that have bonus damage to mech I think (will confirm at day 2)
-NEW UNIT: Shredder - Stationary runby protection unit. in "defense mode" it locks down an area about the side of your average choke in a circle around it, dealing damage and slowing any enemy units that enter it. Disables when any friendly units enter in it's matrix.
-NEW'ish UNIT: Battle Hellion - Transforms the Hellion into a walker mode, changes fire aoe into conal with shorter range but wider radius, same damage, same attack speed, but gains hp in this form (135). -- NOTE, i tested this against 2 marines just to see in cost efficiency, even with blue flame, at 3/3 the battle hellion form lost to just 2 marines with stim and 3/3, AND only dealt splash damage to 1 of the marines despite them being next to each other, the splash will mostly be effective against melee units only.
- Carrier is removed from game.
- Nexus now has 3 abilities: Chronoboost (old), The ability to turn any building into an auto turret temporarily, recall (yeah, recall)
- NEW UNIT: Tempest - Replaces Carrier, AoE splashy damage to air, attacks at moderate pace, bonus damage to light. Ground damage is a lazer beam similar to the mothership attack spliced with void ray attack.
- NEW UNIT: Replicant - Built from Robo, cheaper than a colossus, but more expensive than a stalker (don't remember the exact numbers). Has 1 ability, and no attack, can become any non-massive ground unit (takes 4-5 seconds to transform), including enemy units (even builders!). Seems to have limited use due to cost and non-massive, but can potentially change tides of battle with tanks/ghosts/infestor mimicry
- NEW UNIT: Oracle - Air Caster unit, no attack, can target a building to stop it from attacking/building, can target a building and see what it is manufacturing for 2 minutes, can freeze in a HUGE AOE (size of an entire mineral patch + CC) any mineral lines preventing them from mining, for X amount of time. first 2 abilities are seemingly poorly tuned or not useful. However, 3rd ability, in practice, when getting 4-5 of these and banking them while building up death ball, can completely shut down mining in multiple bases for extend times, or chain freeze 1 base for long periods of time. Seems overpowered, even InControl thinks so, but holding judgment due to being in alpha/beta.
--Didn't get a chance to play, will give a report tomorrow, for now here's the img
- NEW UNIT - Viper - Air Defiler basically, with a Mortal Kombat/Scorpion style CMERE move that pulls units towards itself (including enemy units). Range seems to be around 8-9 in demos, and can be used even on massive units.
- NEW UNIT - Swarmer - Burrows to spawn waves of units to attack enemy lines. Modern day lurker, but instead of spines, it spawns little broodling type units instead. interesting, not sure how powerful yet.
Zerg Campaign for HOTS was pretty fun, storyline is compelling, upgrades seem cool, and Kerrigan upgrade paths are unique and like promised she is very much so involved in the campaign missions in actual combat.
Reminder, these are first iterations, there will be a full beta for HOTS, and any and all units/spells/stats/numbers can be altered before release, so try not to get too crazy with the unit announcements.
Last edited by Kazeyonoma; 10-22-2011 at 02:53 AM.
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Derp I misread. I guess then that Pandaren Monks will use Agility Fist weapons, Polearms or an agility Staff? Staff might be optimal for healing, polearm for tanking and fist weapons for DPS, makes the most sense anyway.
Firstly this expansion has some good points; the talent system now looks a lot nicer for many classes very different the kind of change that would have been apreciated for cataclysm and it's always nice to have a mini game to keep players occupied. Raid finder is a mixed blessing but it will mean you aren't bored everytime your guild disbands or you leave a guild or just cant play as often. So in terms of changes to the game this is a pretty ok bargain in that it is refinement of everything they have changed in the previous expansions.
Now i'm afraid thats where this post ends being on a good note so please ignore the rest of this if you think pandas are great and an expansion that sounds like it is going to be the equivallent of the phantom menance (no real protagonist or antagonist).
WoW expansion announcement started out with Metzen saying this expansion is about WAR but pandaren are peaceful and will help us discover who we are. Ok big contradiction here, is this an expansion about the alliance and horde finally being able to fight it out without someone trying to 'take over the world' or is this just like the Sha'tar teaching us to work together and put asside old conflicts. Obviously new battlegrounds suggest its not but it doesn't make much sense in my mind. I'd also like to say you are right about the draenei they were a surprise and a big lore upset I don't think anyone really liked that idea but eventually it did pan out as the story behind them was ok. Worgen made sense much more so, also why aren't we getting a hero class per second expansion? It seems they decided the DK was a bad idea and didn't want to live through that instead opting for a 1-90 class, sadly my mind has wondered and remembered a melee class without an auto attack, cool but how annoying must it be to do dailies and mindless stuff when you have to be pressing buttons to do damage? It just doesn't fit a game where auto attacks are bread and butter.
The bad-guys we fight in raids and dungeons have been living on the same island as the peaceful pandaren but only now are causing problems? Where do these bad guys come from what the hell is happening? There were so many well known avenues that could have been pursued better: Aszhara, Emerald Dream, Old gods, the burning legion and titans. While not the most exciting prospects for these lore pieces these are what made Warcraft interesting. Pandaren may have been in Warcraft 3 but then it was more comic relief (HECK there was an april fools about panderans!).
The only reason we are taking all the information at blizzcon seriously is because it is blizzcon otherwise and legendary pretty much wore tin-foil hats until blue posts tried to hint away that MoP might be something else. Bouncy, pet battles and repackaged grind quests all suit april fools more than blizzcon.
Pandaren should have entered WoW I am not saying they are a bad addition but they are more suitable as a content patch (even as a peaceful mediator/trainer of both sides) instead of the theme of an expansion. Oh and yet another tank, dps and healer. Yes the healer would have been a good addition but another tank is hardly necessary. That is all I have to say, I feel like i've been rickrolled and I don't actually play the game anymore.
PS someone should shout at them for planning to rehash more old content, no just no. Your old content was good for its time reusing it is just going to get you called lazy even if you aren't bad enough I had to do some troll heroics when i tried to pick up WoW again and I didn't ever get tired of ZG and ZA :\


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The Middle East and North Africa span both poles of migration: as countries of migrant destination, particularly in the Gulf Cooperation Council countries, and as countries of migrant origin. The region has a large supply of young, active workers, with more than 20 million migrants working elsewhere in the region or in Europe. The research here focuses on labor migration to the region, including the policies and regulations that govern such migration and the role of recruiters; the humanitarian flows that have resulted from wars and political instability; diaspora engagement; and more.
Morocco has evolved into one of the world's leading emigration countries. European immigration restrictions did not stop migration, but rather pushed Moroccan migrants into permanent settlement, prompting large-scale family reunification. Morocco is also becoming a destination country, and the growing presence of immigrants confronts Moroccan society with an entirely new set of social and legal issues typical for immigration countries, as this country profile explores.
With some countries narrowing their legal immigration channels, raising the bar for asylum, and increasing security measures at airports and land borders, migrants took unprecedented – and deadly – risks that captured headlines in 2005.
Lors de la deuxième moitié du 20me siècle, le Maroc s'est transformé en l'un des principaux pays d'émigration du monde. Les marocains constituent une communauté de migrants parmi les plus larges et plus dispersées en Europe de l'ouest.
A source for Europe's labor needs since the 1960s, Moroccan migrants and their remittances are central to the economy back home. But as Hein de Haas of Radboud University Nijmegen explains, Morocco is also becoming a transit and immigration country for migrants from sub-Saharan Africa.
Israel is home to Jews and Jewish immigrants as well as Israeli Arabs, Palestinian refugees, and others. But the arrival of foreign workers in the 1990s has further complicated the country's migration issues, as Martha Kruger reports.
An ILO study of Bahrain, Kuwait, Lebanon, and the United Arab Emirates highlights the special risks of domestic work for women. Gloria Moreno-Fontes Chammartin discusses the findings and implications.
Although the number of refugees displaced from the conflict in Iraq was significantly fewer than expected, the war produced some 260,000 internally displaced persons (IDPs) in the North. Recent reports indicate that despite the threat of inter-ethnic retaliatory violence, many of these IDPs are now returning home.
In the aftermath of the 9/11 attacks on the U.S., EU officials issued a symbolic statement that the EU was prepared to receive Afghan refugees displaced from the looming American intervention. Despite internal policy tendencies to reject Afghan claims to protection and domestic security concerns, EU officials seemed to recognize at the time there was very little risk of a massive influx of Afghan refugees.
Although the relationship between migration and development has been widely discussed and debated for more than 30 years, a number of unanswered questions and unsettled debates remain. On April 11 and 12, 2003, the Migration Policy Institute sought to advance the dialogue. This report summarizes the key talking points of the high level meeting and offers some key summary remarks.
Amidst heightened security concerns in the post-9/11 world, this policy brief examines international responses to the Iraqi refugee situation and explores various tools that can effectively allow states to reconcile security efforts with the continued commitment to international protection.
This policy brief reviews what happened in the 1991 Gulf War and presents possible scenarios and factors affecting movements of refugees and internally displaced persons in Iraq. Focusing primarily on four potential scenarios, the author evaluates the relative likelihood of each scenario and implications each would have for refugees and IDPs.
This special issue of the Forced Migration Review (FMR) was produced in collaboration with MPI. FMR felt that the implications for refugees and IDPs of the terrorist attacks of 11 September 2001 and the events which followed were so significant that they warranted changing our publishing schedule to accommodate this additional issue.


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TOWSON, Md. (AP) -- Police say a Baltimore County councilman had a blood-alcohol level more than twice the legal limit following his arrest on drunken-driving charges.
Charging documents show Councilman Todd Huff's blood-alcohol percentage was .20 percent. The legal threshold for drunken driving is .08 percent.
Huff was pulled over early Saturday morning in Towson for driving with his headlights off. He stopped in the parking lot of a tire and auto repair business he owns.
The documents show the Republican councilman asked the arresting officer, "Don't you know who I am?" The documents also show he asked repeatedly whether field sobriety tests were necessary and suggested that the officers drive him home and "be done with this." Police say he failed several sobriety tests.
Huff has not responded to multiple messages seeking comment.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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This class, specifically designed for youth, will teach the basics of babysitting, including child safety for all ages, stages of development, activities to do with children, weather safety and personal safety tips. Lunch is included. Some classes are followed by a Family and Friends CPR. If you wish to participate in both classes, you must register for both classes in advance. Class size is limited. This class is designed for youth ages 10-15.
For more information, please call our Class Registrar at 920-459-4636.
DetailsTime: 8:00 a.m. - Noon
Location: St. Nicholas Hospital - Christopher Room
If you arrive prior to 8:00, please stay with your child. The instructor uses this time for setting up.
Cost: $30.00
View complete course list for "Babysitting"


text: LFG will great for leveling as prot! You learn to tank along and get lots of experience in a dungeon/ raid type environment. Rather than questing protection which i had to do. Because when i was leveling there was no LFG! Which made me a not so great tank when i first hit 80. I had to study my class way more than intended though soon i found myself a better tank after 1 month of 80 from expirience. You will get the experience you need and not have to go through what I did! Good luck on leveling Sharkain!


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Gurudev, life has come to a standstill before a major decision. I often wonder whether my decision will be right or wrong. How can I take the decision?Just look back at your life in the past. This is not the first time that your mind is confused in a dilemma. You have faced these types of questions and situations many times earlier as well; and every time you have received help to overcome it. And whenev ...
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Pokemon Switching Statistics - August 2009
Discussion in 'Pokémetrics' started by Cathy, Sep 15, 2009.
Page 1 of 3
Page 1 of 3


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presented by Ashlee Fence
Duke Energy Convention Center
3:00 p.m. – Doors Open
4:00 p.m. – Tournament Starts
Have you ever wished to play Texas Hold 'Em alongside your favorite Cincinnati Reds? If so, the Reds Community Fund has the perfect event for you this year at Redsfest!
The ninth annual Prestige Audio Visual & Creative Services Reds Community Fund Celebrity Poker Tournament presented by Ashlee Fence is scheduled for Saturday, December 6, 2014 in Ball Room "A" on the third floor at the Duke Energy Convention Center. The doors will open at 3:00 p.m. for registration and side games, and the tournament will begin at 4:00 p.m.
Each table of 10 will feature a current or former Reds player, coach, broadcaster, or other local celebrity. Plus, if you knock a celebrity out of the tournament, you get the autographed jersey off their back!
At the 2013 event, Bill Kohler, outlasted over 590 poker players to win the 8th annual Reds Community Fund Celebrity Texas Hold'em Tournament and the $11,000 first place prize. The last Reds player to fall was Manny Parra finishing in 29th place. Todd Frazier and Jack Hannahan finished in the top 50 players.


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The Carters have arrived in Paris for the European leg of Beyonce's latest tour. The singer grabbed lunch at the Szptime restaurant with her husband Jay-Z and daughter Blue Ivy, who has joined her mummy on her Mrs Carter World Tour, before hitting the stage in the French capital. Bey welcomed some of the world's most glam folk in the audience including model Karlie Kloss who tweeted: "Guess who I saw perform tonight in Paris…?"
While her big sister Peaches has just given birth to her second child, Pixie Geldof has been doing some nurturing of her own. The model, 22, revealed her green-fingered exploits in a fairytale garden featuring toadstools.
And finally, Nicole Richie popped into QVC yesterday and joked "QVC kicked me out at 1am like a bad booty call, and I'm coming back tomorrow for more... like a bad booty call." Only A-listers wear sunnies at 1am!
Check out the top Instagram pictures of the day in the gallery above...


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* Actualo stamina can only be an integer, not a floating point number (although should be used as float vs armor)
* Last time I visited EJ, resistance cap vs +3 targets was 510 (wiki typo?)
* B31 is wrong. It is named Sta / Base Sta but includes the ICC buff (which is a HP buff, not stamina)
* You get 2 Armor per Agility, not 1
* Cells D34 & E34 have no significance within the spreadsheet
* The delta-table should not use averages as a base to calculate the difference, that's what derivates are for.
* A Parry does not automaticly mean an 'extra' hit, it means the next hit will occur faster. It does not change the chance to be hit X times in a row, nor does it change the value of pure EH. Only the time your healers have will be shortened.
* Your information on a parried attack is wrong, as well as your assumption that a 'extra' attack from a Parry will automaticly be a hit.
It's definately a better first post than the average, but you're still missing some things to make the spreadsheet really useful.