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In two relatively short years, Sarah Burton has gone from being the right hand woman of one of Britain's most talented and controversial designers to being something of a national treasure. Her talent has protected the label's hot ticket status in Paris. And the Royal Wedding Dress made her a household name.
Outside the show venue last night there were crush barriers to keep crowds of fans who had gathered just to watch the audience arrive. Within mere seconds of pictures being posted on the web, they had been re-posted, re-tweeted and 'liked' on facebook and instagram hundreds of times.
She has also managed to bring the softness of romance to the often uncompromising vision that was Alexander McQueen's. The impact is there but the darkness has gone. The first model out last night with her scraped back peroxide bob and face covered in a mirrored visor was a vision of futuristic elegance with her frothy layers of sculpted A lines: her tiered skirt under her elbow length cape worn over high mongolian lamb boots with heels carved out like little trotters. She was impressive but totally without that old McQueen menace.
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Sarah Burton's skill is indisputable but it feels like she still has something to prove. This was one of the first collections that genuinely felt so much her own that it seemed almost impossible that Lee McQueen could have had anything to do with it. And, for Sarah Burton and for the future of the brand that is a good thing. But the clothes still challenge the idea of wearability beyond the wardrobes of the likes of fashion's Formula 1 dressers such as Anna Dello Russo or Daphne Guinness.
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by Paula Reed in Paris

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MOUND CITY, Ill. — An Illinois prosecutor says he won't pursue charges that Chicago Bears offensive lineman J'Marcus Webb had marijuana in his vehicle during a traffic stop.
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The 6-7, 333-pound Webb has started 44 games in his first three seasons with the Bears since being drafted in the seventh round in 2010 out of West Texas A&M.
The Bears are aware of the arrest and are "gathering information."


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Bugging the Middle Years
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Joined: 08 Oct 2006
Posts: 1577
Location: Ontario, Canada
Posted: Mon Mar 08, 2010 3:01 pm
Post subject: Bugging the Middle Years
Historically, the Seltorian Hive Ship
Burning Torch of Vengeance
did not arrive in our galaxy until long after the Middle Years were over - conveniently (for the locals, at least) after the refits and new ship classes which brought the Alpha Octant up to the level that the M81 Galaxy ships had been at before them.
However, say if one wanted to run a scenario in which the Seltorians arrived much earlier, during the course of the Middle Years. What kind of options would their Alpha Octant opponents put on the table, to try and counter them?
(For argument's sake, say that the Seltorians would be limited in terms of what they could build/deploy from the Hive Ship, and that the ships they built historically with Klingon help - the DNL and NCA - would not be available.)
Indeed, given the smaller (and weaker) ships at the Holdfast's disposal during this era, would this turn of events spell bad news for the Tholians - or can they at least hold their own (in a defensive position, say when trying to protect a BS or SB) against their most hated foes?
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Location: Dallas, Texas
Posted: Mon Mar 08, 2010 4:22 pm
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If the Seltorians arrived during the Middle Years*, the Tholians would be dead. Their NDD and NFFs would die quickly, and they hadn't even designed the DD yet. The pathetic Tholian defense would be crushed in fairly short order.
At that point, the Seltorians would have to decide whether to stick around or not. They could really screw up the Klingons (and Feds) if they chose, though I am sure the Galactics could eventually overwhelm them with pure numbers.
It would be interesting to see what new alliances could evolve from this. With the Federation and Klingons likely forced to fight together against a common enemy, alliances could end up being radically different! The Hydrans might never be conquered, and the Kzinti might be completely screwed (since now *all* of their neighbors hate them!) The Romulans are likely screwed, too, as the new alliances would likely prevent the eventual Klingon partnership with them.
Most likely, however, the Seltorians would be happy with a job well done and just leave. Their leaders aren't idiots, and they have to know that their single Hive ship cannot take on an entire Galaxy of opponents. And, having just demonstrated their utter ruthlessness, I doubt any of the Galactics are going to want to be friendly, either.
An interesting side effect of this, however, is if the Seltorians do leave, and don't cause much damage to the Klingons while doing so, then the Romulans are well and truly screwed.
So, in the end, if the Seltorians arrived during the Middle Years, and everything else is relatively equal, the fairly obvious results are:
1) Tholian Holdfast is dead in short order.
2) Seltorians leave.
[*] I say "Middle Years", but I was thinking "Early Years". Thus, the disconnect between the leading statement and everything that follows. My bad.
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Last edited by mjwest on Mon Mar 08, 2010 7:24 pm; edited 1 time in total
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Location: Ontario, Canada
Posted: Mon Mar 08, 2010 5:35 pm
Post subject:
Just to clarify, the Holdfast would have no more NDDs or NFFs, but would have DDs, POLs and Cs, as well as the various units listed in
Briefing #2
, such as light and heavy monitors, base stations, starbases and what have you.
When it comes to the Selts leaving, there's no guarantee there wouldn't other Tholians on the way - such as the 312th and the ships which eventually went to the Draco Dwarf Galaxy.
(Although, perhaps Draco would end up getting two waves of immigrants - one from a re-routed 312th, then another from the
War Havoc
's fleet later on...)
EDIT: In
terms, I was assuming that a Romulan player would have their Middle Years ships also - although maybe one could experiment with a no-KR option and only give them the Eagle-series hulls? (Perhaps they got help from someone else instead of Smarba.)
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Joined: 08 Oct 2006
Posts: 3498
Location: Dallas, Texas
Posted: Mon Mar 08, 2010 7:22 pm
Post subject:
Oh, wait. You said *Middle Years*. I was thinking *Early Years*. My bad.
Let's try this again.
What would likely happen if the Seltorians show up in the Middle Years, is basically what happened historically, except that Tholians eventually die.
Since the Tholians are already established by Y120, and have started producing the C and other ships, they would be a much tougher nut to crack. So, it is likely the Klingons would still let the Seltorians settle down on the same world they got later, and they would then start working on producing ships and building a fleet, all the while annoying the Tholians.
Then, at some point between Y130 and Y150, the Klingons would have been between wars for long enough to focus on the Tholians. At that point, the Seltorians would not have enough of a fleet to succeed at an assault on their own, but would be able to help the Klingons in a joint assault.
And then the Tholians die.
Once the Tholians are dead, the Seltorians would pretty much have to leave. There purpose in the Milky Way is gone, and they have zero hope of conquering just the Klingons, much less anyone else. If the Klingons play it right, they would make sure the Seltorians take the brunt of the assault on the Tholians, then kill the remnants after the war. No reason to leave loose ends around.
And that is pretty much the difference. There might be one or two less wars with the Klingons involved, as it would take longer for them to rebuild their fleet after that. I don't see the 4PW or GW being derailed, however. The Romulans might actually get help from the Klingons earlier, because the Klingons would need pressure on that front to keep the Federation off their backs. Other than that, I don't see much difference.
Actually, I am liking the Early Years arrival scenario better ...
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Posted: Mon Mar 08, 2010 10:49 pm
Post subject:
One thought I had was for the Seltorians to show up in 2550.
At this point, the Feds and Klingons were historically only a few years away from the war which the Organians put a stop to. At this point, relations between the two powers would already be quite tense.
Enter the Hive Ship. If the Klingons allow the Selts to use their space as a launch pad for a campaign, Star Fleet might start getting a little itchy about this turn of events - especially if, say, the Klingons 'volunteer' the Tholian Border Squadron under Limited War.
However, if the TBS is deployed, the Klingo-Selt coalition might find the Tholians backed up by the Federation Seventh Fleet, taking part in a limited war of its own.
(This could launch the larger Fed-Klingon war a few years earlier - or it might simply add fuel to the fire. However, even if the Organians intervene this time around, would that stop the forces already in Tholian space?)
So, in
terms, one could have
Fed ships alongside Middle Years Tholians in a fight against
Klingons and the Seltorians - with perhaps the odd Middle Years Orion raiders crashing the party.
What kind of tactics would the Middle Years Star Fleet (or Tholians or Orion Pirates, for that matter) use if obliged to start shooting at Seltorian ships/fleets/convoys/etc, Klingon-allied or no? Can the superior weight in numbers and the presence of heavier command ships take on the somewhat smaller, but Main Era-equivalent ships of the Tribunal fleet?
(In such a scenario, I'd still keep the Selts from getting their three-boom hulls. In-universe, perhaps the Klinks needed to work out newer warp technologies to work the problem out. From a campaign perspective, I'd want to oblige the Selts to not rely on DNLs and NCAs...)
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Joined: 03 May 2008
Posts: 1865
Location: Earth
Posted: Tue Mar 30, 2010 11:53 am
Post subject:
When the seletorians did arrive historically, they imeadiatley threw everything they had at the tholians, which cost them victory. So I would say that if the federation intervened, the seletorians would be stopped, unless the klinks attacked the feds, in which case the feds would pull back the fleet on the tholian border.
But I doubt the Feds would bother helping the tholians. They don't gain anything, and it would raise hostilities with the klinks.
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Clint Eastwood Gossip
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Bradley Cooper: 3 for 3?
Here's Bradley Cooper arriving in London. Hair's getting long. Since the American Sniper trailer came out people have now added it to the Oscar long list of contenders. That happens any time Clint Eastwood directs a movie. He's not young anymore, that guy. And it'll be his second directorial release this year. Full Story
Sienna supports Tom
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Sienna Miller supported her partner Tom Sturridge at the London premiere of Effie Gray this weekend in London. Great print on that dress. They seem happy and relaxed together. Not that it's any of my goddamn business but I'm relieved to see that. Professionally, it's not a good time for Sienna to get restless. Full Story
DDL vs Clint Eastwood and the "old white men"
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Daniel Day-Lewis was honoured the other night at BAFTA LA. Have you seen his acceptance speech? It was dedicated to Clint Eastwood's Obama chair. The President had just won re-election the night before. Conservatives were in a tailspin. And here's a British actor taking the piss out of a Hollywood legend. Full Story
I guess that explains Justin Timberlake...
And why Clint Eastwood cast him in his next movie. Because, obviously, he's OUT OF HIS F-CKING MIND.Click here for my initial thoughts on Clint Eastwood's wife and daughters and their reality show, specifically in reference to Daniel Craig's comments about celebrity famewhoring and the Kardashians. Full Story
Romeo & Juliet!
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I know I've mentioned this before...But I LOVE Baz Luhrmann's Romeo & Juliet. It's in my personal Top 10 of all time, that's how much I love it. Thank you Eleni and Corelli for giving me the DVD. I should watch it tonight since Leo's rekindled my quiver.Anyway, the AFI Awards are happening in Hollywood this afternoon and look!It's Leo and Claire! It's Romeo and Juliet!Just for fun, I'm pulling some old photos of the two in similar poses. Full Story
Daniel Craig's morning cheer
Oh hey Crusty! How's this? A smile during an interview? Some good humour on The Today Show? But you hate the dog and pony show! As you know, I'm kinda tired of Daniel Craig's whinging about the media and publicity and spotlight and attention paid to his personal life. I've already written about it at length here Full Story
Nepotism Reality TV - where are you Daniel Craig?
Francesca Eastwood is the daughter of Clint Eastwood and his ex-wife Frances Fisher. She is 18. She wants to be an actress. Oh the times. Oh our times. Clint Eastwood can't get his daughter an acting gig... but he can get her a reality tv show. And so here we are. TMZ Full Story
Clint & Leo present J Edgar
J Edgar opened the 2011 AFI Fest in Hollywood last night. The film will hit theatres next Friday and then we see whether or not it will factor during award season. I've only read two reviews so far (THR and Screen Daily Full Story
This must just be a bad trailer
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Leo > JT
I've been tied up on TIFF business for days so I've had to catch up on all the non-TIFF I've missed including the new magazines, etc. Was digging this Justin Timberlake spread in the new Esquire when I first saw it. He looks good. The article itself, about when he went to Comic-Con and dressed up as Ernie and how liberated he felt and eyeroll eyeroll eyeroll is predictably insufferable. Full Story
Leo on set: pyjamas to tuxedo
Clint Eastwood is known for motoring through a shoot. He's nothing if not efficient. And so Leonardo DiCaprio was on set yesterday filming in several costumes, first at the house, in pyjamas, and then at night with Dame Judi Dench and Armie Hammer, who plays his lover, all dressed up for a black tie affair. Full Story
Leo's full face
Yesterday in this article about Hayden Christensen, I posited that when men get full faces, they don't ever get their faces back – a rare female advantage. During the LiveBlog, Leonardo DiCaprio was suggested by one of the commenters as an another example. Full Story
Chuck Bass goes big time
Ed Westwick is that you? From Gossip Girl to Clint Eastwood? Blake Lively will be jealous. For real. It's a major professional accomplishment for Ed Westwick – Deadline reported yesterday that he's signed onto Eastwood's upcoming J Edgar Hoover film with Leonardo DiCaprio in the lead. Full Story
It's all coming to TIFF
Holy. Sh-t. More TIFF announcements, more major additions, so many world premieres at this year's film festival including the Midnight Madness line-up and more potential award winners to the schedule covering the entire spectrum from elder Hollywood statesman to dirty tramps and roughnecks. Clint Eastwood will be in Toronto with Hereafter starring Matt Damon. Full Story


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Watch for Nikki at a motorcycle stunt show near you: she'll be traveling across the U.S. promoting her appearance in a stunt team's calendar. Working in the entertainment business has always been a dream for Nikki--her parents are both actors--but she's still too young to kn...
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Saturday, February 8th from 2:30 pm to 4:00 pm
"Five Women Wearing the Same Dress," a second stage theatre production, is presented at 8 p.m. Friday and Saturday, and at 2:30 p.m. Sunday in the Glaize Studio Theatre. Tickets are $10 for adults, $9 for senior citizens, and $10 for non-SU students. Complimentary tickets are available in advance for employees and students with SU I.D. Visit www.conservatoryperforms.org or call the box office at 540/665-4569 for more details.
- Glaize Studio Theatre, Ruebush Hall
620 MILLWOOD AVE., Winchester, VA, 22601, United States
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The body of 11-year-old Jodi Parrack showed evidence of bruising on her neck, abrasions consistent with handcuffs on both wrists and contusions to both nipples, according to a 2007 autopsy report reviewed by the Sturgis Journal.
Four St. Joseph County residents –John Bippus, Aaron Miller, Roger Rathburn and Bob Sills — will square off Tuesday, with the winner representing the Republican party in November's general election.
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The highest possible hand in poker. Playing Hold 'em, if you hold As, 3s and the board is Qs, 8s, Kd, 2s, 9c you are said to be holding "the nuts." The terminology is said to refer to the fact that poker is a partial information game, meaning that when you bet, you don't know if you're winning or losing. This being the case, you have to have "nuts" (as in testicles) to have the nerve to bet. The only case when you can bet in poker without "testicles" would be if you had the best possible hand and could not be beaten, hence the term "nuts"
Joe won that large pot over Carl because Carl only had a flush, but Joe had the nuts with four of a kind.
Beküldő: Poker Player 2004. március 29.
A word yelled by the rude nig nog woman at Willo's Party, pronounced wrongly as "Hhnaats!" She would only say it about every two minutes when she's eaten all of her nog nuts and when not yelling "Freed!" Willo would then kindly feed the Nogger it's elephant food while it was yelling "oo, oo, ee, ah!" The chimp would not give any of it's masses of food to it's husband, "Cleveland."
Nog: Me eaten de five handred pound o' hhnaats mon.
Willo: Here's your nuts.
Nog: Piss off Cleveland, mon! Only
me eat a da elephant food mon! You eat a da chimp
food Mon!
Willo: Here's your nuts.
Nog: Piss off Cleveland, mon! Only
me eat a da elephant food mon! You eat a da chimp
food Mon!
Beküldő: Ednatoast Jeeganflipperwick 2009. június 7.
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Allogeneic Transplant in HIV Patients (BMT CTN 0903)
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The rationale for this trial is to demonstrate the feasibility and safety of allogeneic HCT for patients with chemotherapy-sensitive hematological malignancies and coincident HIV-infection. In particular, the trial will focus on the 100-day non-relapse mortality as an indicator of the safety of transplant in this patient population. Correlative assays will focus upon the incidence of infectious complications in this patient population, the evolution of HIV infection and immunological reconstitution. Where feasible (and when this can be accomplished without compromise of either the donor quality or the timeliness of transplantation), an attempt will be made to identify donors who are homozygotes for the delta32 mutation for CCR5.
Drug: Fludarabine and Busulfan (Flu/Bu)
Drug: Fludarabine and Melphalan (Flu/Mel)
Drug: Busulfan and Fludarabine (Bu/Flu)
Drug: Cyclophosphamide and Total Body Irradiation (Cy/TBI)
Drug: Fludarabine
Drug: Busulfan, Fludarabine, Cyclophosphamide
Phase 2
|Study Type:
|Study Design:
|Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Allogeneic Hematopoietic Cell Transplant for Hematological Cancers and Myelodysplastic Syndromes in HIV-Infected Individuals
- Non-Relapse Mortality [ Time Frame: 100 days ] [ Designated as safety issue: Yes ]The events for non-relapse mortality are death due to any cause other than relapse of the underlying malignancy
- Disease Status Following Transplant [ Time Frame: 100 days ] [ Designated as safety issue: Yes ]Patients will be assessed for disease status at Day 100 post-HCT: complete remission, partial remission (HL, NHL), stable disease (HL, NHL), relapse.
- Chimerism [ Time Frame: 4 weeks, 100 days and 6 months ] [ Designated as safety issue: Yes ]Blood samples will be evaluated for T cell and myeloid chimerism at 4 weeks, 100 days and 6 months post-transplant.
- Incidence of Infections [ Time Frame: Date of transplant through one year post-transplant ] [ Designated as safety issue: Yes ]Microbiologically documented infections will be reported by site of disease, date of onset, severity, and resolution, if any.
- Six Month Overall Survival [ Time Frame: Six months post transplant ] [ Designated as safety issue: Yes ]Overall survival is defined as time from transplant to death or last follow-up.
- Acute Graft-versus-Host Disease (GVHD) [ Time Frame: 100 Days ] [ Designated as safety issue: Yes ]Acute GVHD will be graded according to the BMT CTN Manual of Procedures. The time to onset of acute grades II-IV GVHD and grades III-IV GVHD will be recorded, as well as the maximum grade achieved.
- Chronic Graft-versus-Host Disease (GVHD) [ Time Frame: 100 days, 6 months, 2 years ] [ Designated as safety issue: Yes ]Chronic GVHD will be scored according to the BMT CTN Manual of Procedures. The time to onset of limited and extensive chronic GVHD will be recorded.
- Immunologic Reconstitution [ Time Frame: 8 Weeks; 6, 12 and 24 Months ] [ Designated as safety issue: Yes ]This will be measured in all patients at 8 weeks, 6 months, 12 months and 24 months post-transplant. Tests to be performed on peripheral blood at those time points include CD2, CD3, CD4, CD8, CD19, CD3+/CD25+, CD45 RA/RO, CD56+/CD3-, and quantitative immunoglobulins (IgM, IgG and IgA).
- Impact of Therapy on the HIV Reservoir [ Time Frame: Day 100, 6 Months, 12 Months, and 24 Months ] [ Designated as safety issue: Yes ]HIV-1 RNA in plasma will be measured by standard real-time RT-PCR (detection limit 40 copies/ml) and by the investigational single copy assay (SCA, detection limit 0.38 copy/ml). HIV-1 DNA in peripheral blood mononuclear cells (PBMCs) and other cells will be quantified using the same primers and probes used for SCA but without a reverse transcription step. HIV-1 RNA levels will be measured in plasma prior to the initiation of ablative chemotherapy, and at Day +100, 1 and 2 years post-transplant.
- Hematologic Function [ Time Frame: Day 100, 6 months ] [ Designated as safety issue: Yes ]Hematologic function will be defined by ANC greater than 1500, Hemoglobin greater than 10g/dL without transfusion support, and platelets greater than 100,000 and measured at Day 100 and 6 months. Use of growth factors will be noted.
|Estimated Enrollment:
|Study Start Date:
|September 2011
|Estimated Study Completion Date:
|November 2015
|Estimated Primary Completion Date:
|November 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Allogeneic Transplant
In general reduced-intensity conditioning (RIC) is reserved for patients with co-morbidities or older patients in whom regimen-related mortality weighs against myeloablative conditioning (MAC). However, the selection of a RIC or MAC regimen in any particular patient is left to the discretion of investigators at the participating center in accordance with institutional standards.
Drug: Fludarabine and Busulfan (Flu/Bu)
Drug: Fludarabine and Melphalan (Flu/Mel)
RIC Regimen: Fludarabine total dose: 120-180 mg/m^2, Busulfan: ≤ 8 mg/kg PO or 6.4 mg/kg IV). Recommended regimen:
The sequence of fludarabine and busulfan administration in RIC regimens will be done according to institutional standards. Intraveneous busulfan may be administered in divided doses or once daily. Oral busulfan must be administered in divided doses. Busulfan dose adjustments for obesity are listed in Section 126.96.36.199 of the protocol. Fludarabine dose adjustments for renal impairment are listed in Section 188.8.131.52.
See Section 2.5.4 and Table 184.108.40.206 of the protocol for critical information about antiretroviral management in the setting of a busulfan-containing reduced intensity conditioning regimen when the antiretroviral regimen includes ritonavir.
Drug: Busulfan and Fludarabine (Bu/Flu)
RIC Regimen: Fludarabine total dose: 120-180 mg/m^2, Melphalan total dose: less than or equal to 150 mg/m^2. Recommended regimen:
The sequence of fludarabine and melphalan administration in RIC regimens will be done according to institutional standards as long as the prescribed doses are the same as the regimen above. Dividing the dose of melphalan over two days is permitted. Fludarabine dose adjustments for renal impairment are listed in Section 18.104.22.168 of the protocol.
Drug: Cyclophosphamide and Total Body Irradiation (Cy/TBI)
MAC Regimen: Fludarabine total dose: 120-180mg/m^2 Busulfan total dose less than or equal to 16mg/kg PO or 12.8 mg/kg IV. Recommended regimen:
The sequence of busulfan and fludarabine administration in MAC regimens will be done according to institutional standards. Busulfan may be administered intravenously in divided doses or once daily. Appropriate busulfan dosing adjustments per institutional standard should be made when levels are available to achieve the target Css. Busulfan dose adjustments for obesity are listed in Section 188.8.131.52 of the protocol. Fludarabine dose adjustments for renal impairment are listed in Section 18.104.22.168 of the protocol.
Drug: Fludarabine
MAC Regimen: Cyclophosphamide total dose: 120 mg/kg, Fractionated TBI total dose: 1200-1420 cGy Recommended regimen:
The sequence of cyclophosphamide, TBI and TBI administration practices in MAC regimens will be done accordingly to institutional standards. Cyclophosphamide dose adjustments for obesity are listed in Section 220.127.116.11 of the protocol. See Appendix F of the protocol for detailed information on pharmacokinetic interactions. MESNA will be given to reduce the risk of cyclophosphamide-associated hemorrhagic cystitis. MESNA will be dosed based on cyclophosphamide dose and may be administered per institutional guidelines.
Drug: Busulfan, Fludarabine, Cyclophosphamide
MAC Regimen (conditioning agent dose adjustments for renal impairment):
Patients with a creatinine clearance of 40-70 ml/min (measured or calculated) should have a 20 percent dose reduction.
MAC Regimen (conditioning agent dose adjustments for obesity):
Detailed Description:
The study is designed to evaluate the feasibility and safety of reduced-intensity and fully-ablative allogeneic hematopoietic cell transplantation (HCT) for patients with hematological malignancies or myelodysplastic syndromes (MDS) who have HIV infection. The goal of the study is to assess the 100 day Non-relapse Mortality as well as immunological reconstitution in this patient population. Where feasible, an attempt will be made to identify HLA-compatible hematopoietic stem cell donors who are homozygotes for the delta32 mutation of the chemokine receptor 5 (CCR5delta32). Patients will undergo a treatment plan review prior to registration on the trial. All patients will undergo allogeneic HCT from a matched sibling or unrelated donor.
|Ages Eligible for Study:
|15 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV-1 infection, as documented by a rapid HIV test or any FDA-Approved HIV-1 Enzyme or Chemiluminescence Immunoassay (E/CIA) test kit and confirmed by Western Blot at any time prior to study entry. HIV antigen, plasma HIV-1 RNA, or a secondary antibody test by a method other than rapid HIV and E/CIA is acceptable as an alternative test. Alternatively, if a rapid HIV test or any FDA-Approved HIV-1 Enzyme or Chemiluminescence Immunoassay (E/CIA) test is not available, two HIV-1 RNA values greater than or equal to 2000 copies/mL at least 24 hours apart performed by any laboratory that has CLIA certification, or its equivalent, may be used to document infection.
- Patients must be willing to comply with effective Antiretroviral Therapy.
- Patients must be greater than or equal to 15 years of age.
- Hematological malignancy associated with a poor prognosis with medical therapy alone. Diagnoses to be included: a)Patients with the diagnosis of Acute Myeloid or Lymphocytic Leukemia (AML or ALL) in first or second complete remission; b)Patients with advanced myelodysplastic syndromes (MDS), including those with International Prognostic Scoring System (IPSS) Int-2 and high-risk disease with less than 10 percent marrow blasts and no circulating myeloblasts after most recent therapy. Patients with acute leukemia that develops from a pre-existing MDS must meet the inclusion criteria for patients with AML detailed above; c)Hodgkin Lymphoma beyond first remission achieving at least a partial response to most recent therapy with no evidence of progression prior to transplant; d)Non-Hodgkin Lymphoma beyond first remission achieving at least a partial response to most recent therapy with no evidence of progression prior to transplant.
- Donor/recipient HLA matching: a) Related donor: must be an 8/8 match at HLA-A, -B, -C, (serologic typing or higher resolution) and -DRB1 (at high resolution using DNA based typing). A 7/8 related donor match is permitted only if an 8/8 unrelated donor cannot be identified; b) Unrelated donor: must be a 7/8 or 8/8 match at HLA-A, -B, -C, and -DRB1 (at high resolution using DNA based typing).
- Patients with adequate organ function as measured by: a)Cardiac -Left ventricular ejection fraction at rest greater than or equal to 40 percent demonstrated by MUGA or echocardiogram. Patients with known heart disease must have a functional status no worse than American Heart Association Class I defined as patients with cardiac disease but without resulting limitation of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, dyspnea, or anginal pain; bi)Hepatic - Total Bilirubin less than 2.0 mg/dL (except for isolated hyperbilirubinemia attributed to Gilbert syndrome or antiretroviral therapy as specified in the protocol Appendix E) and ALT and AST less than 5x the upper limit of normal; bii)Concomitant Hepatitis - Patients with chronic hepatitis B or C may be enrolled on the trial providing the above bilirubin and transaminase criteria are met. In addition, there must be no clinical or pathologic evidence of irreversible chronic liver disease, and there must be no active viral replication as evidenced by an undetectable hepatitis viral load by a PCR-based assay; c)Renal-Creatinine clearance (calculated creatinine clearance is permitted) greater than 40 mL/min; d)Pulmonary: DLCO, FEV1, FVC greater than or equal to 45 percent of predicted (corrected for hemoglobin).
- Signed Informed Consent
Exclusion Criteria:
- Karnofsky/Lansky performance score less than 70 percent.
- Active CNS malignancy; however, patients with a history of positive CSF cytology that has become negative with intrathecal chemotherapy are eligible.
- Uncontrolled bacterial, viral or fungal infection (currently taking medication and with progression or no clinical improvement).
- Active CMV retinitis or other CMV-related organ dysfunction.
- AIDS related syndromes or symptoms that pose a perceived excessive risk for transplantation-related morbidity as determined by the principal investigator.
- Untreatable HIV infection due to multidrug antiretroviral resistance. Patients with a detectable viral load greater than 750 copies/ml should be evaluated with an HIV drug resistance test (HIV-1 genotype). The results should be included as part of the Antiretroviral Review. This Review Committee will make the final determination as to whether HIV viremia could potentially be suppressed with alternate antiretroviral therapy.
- Pregnant (positive β-HCG) or breastfeeding.
- Fertile men or women unwilling to use contraceptive techniques from the time of initiation of mobilization until six-months post-transplant.
- Prior allogeneic HCT.
- Patients with psychosocial conditions that would prevent study compliance and follow-up, as determined by the principal investigator.
- T-cell depletion (including ATG or alemtuzumab) is not allowed.
- Use of cord blood as the source of hematopoietic cells is not allowed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01410344
|Contact: Mary Horowitz, MD, MS
|Contact: Ellen Parker
|United States, California
|City of Hope National Medical Center
|Not yet recruiting
|Duarte, California, United States, 91010
|University of California Los Angeles
|Not yet recruiting
|Los Angeles, California, United States, 90035
|United States, Florida
|University of Florida College of Medicine
|Gainesville, Florida, United States, 32610-0277
|Contact: John R Wingard, MD 352-273-7760 firstname.lastname@example.com
|H. Lee Moffitt Cancer Center
|Tampa, Florida, United States, 33624
|Contact: Ernesto Ayala, MD 813-745-1554 email@example.com
|United States, Maryland
|Johns Hopkins Medical Institutions
|Not yet recruiting
|Baltimore, Maryland, United States, 21231
|Contact: Richard Ambinder, MD 410-955-8839 firstname.lastname@example.com
|United States, New Jersey
|Hackensack University Medical Center
|Hackensack, New Jersey, United States, 07601
|Contact: Scott Rowley, MD 201-996-5828 email@example.com
|Contact: Melissa Baker, MD email@example.com
|United States, New York
|Memorial Sloan-Kettering Cancer Center
|Not yet recruiting
|New York, New York, United States, 10174
|Contact: Ariel Noya, MD email@example.com
|United States, Pennsylvania
|University of Pennsylvania School of Medicine
|Philadelphia, Pennsylvania, United States, 19104
|Contact: Kim Hummel 215-349-5786 email@example.com
|United States, Texas
|University of Texas MD Anderson Cancer Center
|Houston, Texas, United States, 77030
|Contact: Uday Popat, MD 713-745-3055 email@example.com
|Texas Transplant Institute
|Not yet recruiting
|San Antonio, Texas, United States, 78229
|Contact: Paul Shaughnessy, MD 210-575-6907 email@example.com
|United States, Utah
|University of Utah
|Not yet recruiting
|Salt Lake City, Utah, United States, 84132
|Study Chair:
|Joseph Alvarnas, MD
|City of Hope National Medical Center
|Study Chair:
|Richard Ambinder, MD
|Johns Hopkins University
Additional Information:
No publications provided
|Responsible Party:
|Medical College of Wisconsin
|ClinicalTrials.gov Identifier:
|NCT01410344 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 3, 2011
|Last Updated:
|June 2, 2014
|Health Authority:
|United States: Federal Government
United States: Food and Drug Administration
Keywords provided by Medical College of Wisconsin:
Non-Hodgkin Lymphoma
Additional relevant MeSH terms:
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases
Lymphoproliferative Disorders
Neoplasms by Histologic Type
Fludarabine phosphate
Alkylating Agents
Anti-Infective Agents
Antimetabolites, Antineoplastic
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Antirheumatic Agents
Antiviral Agents
Immunologic Factors
Immunosuppressive Agents
Molecular Mechanisms of Pharmacological Action
Myeloablative Agonists
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
ClinicalTrials.gov processed this record on November 27, 2014


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People dressed as the Russian Santa Claus, Ded Moroz (Grandfather Frost) and his companion Snegurochka (Snow Maiden) stand near a New Year tree at the central Ala-Too Square in the Kyrgyz capital Bishkek, on December 27, 2011. New Year, which was the biggest informal holiday of the year in the former Soviet Union, is also very popular in predominantly Muslim Central Asian nation of Kyrgyzstan. AFP PHOTO / VYACHESLAV OSELEDKO (Photo credit should read VYACHESLAV OSELEDKO/AFP/Getty Images)
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Last fall, we asked Texas Highways readers to share their favorite places in the state for our Texas Top-40 Travel Destinations. And share you did—by phone, email, Facebook, and through many amazingly detailed letters. Thousands of TH readers helped to shape the final list, which we will divulge throughout 2014, Texas Highways' 40th-anniversary year.
Marble Falls' picturesque setting along its namesake lake proves enticing enough, but travelers stick around this Hill Country town for the live music, classic cafés, art galleries, intriguing shops, and annual events that range from a soapbox derby to drag-boat races.
As a Texan exiled for 14 years to Arizona, I feel fortunate to have found decent barbecue, chicken-fried steak, and—halfway through my time there—even Blue Bell ice cream. There was no Tex-Mex, though. And, unfortunately, there was a shocking dearth of pie.
Texas Highways readers are like our field reporters, so find out what these readers recommend.
: Readers Recommend, Texas Highways, Box 141009, Austin 78714-1009. See the print edition for additional details.
Western Hill Country picksMy sister and I explored the western Hill Country. We highly recommend the wienerschnitzel and chocolate hazelnut crème brûlée at the Welfare Café in Welfare, the down-home lunch and yeast rolls at Neal's Lodges' dining room in Concan, the rustic Foxfire Log Cabins at Vanderpool, and The Comfort Common in aptly named Comfort.
At Camp Verde General Store in Camp Verde, we especially liked the gorgeous patio and the whimsical metal sculpture of a camel out front.
SABRINA O'CONNOR, Austin
The Welfare Café is at 223 Waring Welfare Rd. in Welfare. Neal's Lodges is at 20970 Texas 127 in Concan. Foxfire Log Cabins is at 117 Olsen Ranch Rd. in Vanderpool. The Comfort Common is at 717 High St. in Comfort. Camp Verde General Store is at 285 Camp Verde Rd. East in Camp Verde.
O'Leander CaféWhile my wife and I were visiting family in Leander, a local fireman told me that the O'Leander Café had a pecan burger that was "worth dying for." So I went over, met owners Loretta and David Warner, and ordered the O'Leander Pecan Burger, which is cooked with a special pecan-and-onion mix. If you are willing to die for a hamburger, that's one burger "worth dying for!" Along with the burger, I ordered sweet-potato fries and a Pepsi, and was really tempted to try one of their mouth-watering desserts, but I had no room left. We went back to Leander in mid-November and just had to take a little diversion over to the O'Leander Café.
JIM AND RUBY MASTEN, Tyler
O'Leander Café is at 105 W. Willis St. in Leander.
Robert's SteakhouseIn Flatonia, Robert's Steakhouse, formerly Stockman's, has a new owner. Now, Robert Palomera is wooing folks, like me, to drool over the divine $12.99 steak dinner! You get those crispy, wonderful fried onions, a crisp salad, and a great choice of potatoes. Please do check this one out—you won't be disappointed.
KAY KENNELL, San Antonio
Robert's Steakhouse is at 1241 N. Texas 95 in Flatonia.
Jim's Bar-B-Que and CatfishDriving into East Texas at Waskom we saw a billboard sign for Jim's Bar-B-Que and Catfish. I had the (very tender) smoky-flavored pork ribs that practically fell off the bone. They truly have a real pit barbecue out back! My husband had the Cajun-fried catfish dinner, the tastiest catfish he'd ever had. Both dinners were served with choice of coleslaw, potato salad, corn on the cob, or beans, with huge glasses of iced tea! The menu also boasts a country breakfast, sandwich plates, chicken, hot links, beef and pork dinners, burgers, desserts and more.
JANICE PORTER, Alaska
Jim's Bar-B-Que and Catfish is at 770 Spur 156 in Waskom; 903/687-3316.
StetsonOn a recent trip to the coast, we stopped at an out-of-the-way café in Campbellton. Stetson is a vintage '50's-era café run by Jean and "Papa Bear" Roane. Jean said they were famous for their hamburgers and chicken-fried steak, so we took them up on it. The burger was a great, old-fashioned grilled cheeseburger, and the chicken-fried steak was large, tender, flavorful, and all meat under the golden batter. Cold iced tea was served in mason jars and Cokes from the bottle. Jean gives "free advice" and tells colorful stories while "Papa Bear" does the cooking. This café will be on our permanent South Texas-trip agenda!
DON AND DEBBY REEVES, Bedford
Stetson Restaurant is at 2825 Commerce St. in Cambellton; 830/579-4006.
Arnold BurgersYou will find the largest burger in Texas in the smallest place in Amarillo: Arnold Burgers. In an 18-by-30-foot building, the largest hamburger—24 inches with all the fixings-—is served almost daily. Other burgers come in all shapes and sizes, and the smallest item there is called the "hamburger cookie." Yum!
CATHERINE HUNT, Stinnett
Arnold Burgers is at 1611 S. Washington St. in Amarillo.
Texas Highways readers are like our field reporters, so find out what these readers recommend.
Texas Highways readers are like our field reporters, so find out what these readers recommend.
Cowcatchers Steaks
While driving around Bulverde, we found a great restaurant (with great views) called Cowcatchers Steaks. The food is delicious (especially the rib-eye), pricing is reasonable, and the service and venue outstanding. Kids will enjoy the Longhorns and horses in the front and the space to run around. This is the perfect place to take your family for a special occasion that calls for steak.
MARCO BARROS, San Antonio
Cowcatchers Steaks is at 1100 Bulverde Rd.; 830/980-6080.
Ginger Brown's Old Tyme Restaurant and Bakery
TH readers will want to know about Ginger Brown's Old Tyme Restaurant and Bakery in Lake Worth. They have the most delicious home-style meals ever—real chicken-fried steak, meatloaf, chicken and dumplings, pot roast, and chicken potpie (to name a few)—served with traditional vegetables
and from-scratch mashed potatoes and rolls. You will also be served one of Ginger's "made daily" cinnamon rolls with your meal, or you might want to try one of the scrumptious homemade pies (coconut, chocolate, and many more). They have old-time prices, enjoyable décor, and a staff that goes above and beyond to make you feel welcome.
JOYCE BELL, Fort Worth
Ginger Brown's Old Tyme Restaurant and Bakery is at 6312 Jacksboro Hwy.; 817/237-2114.
Doc's Fish Camp & Grill
Doc's Fish Camp & Grill in Marble Falls should be recognized as one of the best steak and seafood restaurants in the Hill Country, if not the state. The restaurant has been around for 15 years and has an interesting story about its conception and rebirth.
Doc's Fish Camp & Grill is at 900 FM 1431 West; 830/693-2245.
Two Amigos Taqueria
Two Amigos Taqueria is a little café two blocks west of the Waxahachie courthouse. The authentic Mexican food is fabulous! Try the nachos with everything on them or a
soft taco made with corn tortillas, seasoned chicken, grilled onions, and cilantro. Need more? The tortilla soup is to-die-for and served in generous portions. Prices are reasonable, and the menu has something for everyone. Some days the café observes a lunch schedule only, but later in the week they stay open through the evening. It's a real treat!
TANA DIXON, Odessa
Two Amigos Taqueria is at 212 W. Jefferson St.; 972/923-3305
The Moosehead Cafe
I recommend The Moosehead Cafe in Crockett. Not only is the food great, the people there are the nicest!
JESSICA and BILLY McRAE, Crockett
The Moosehead Cafe (think burgers, Philly cheese steaks, chicken-fried steaks, and rib-eye sandwiches) is at 412 E. Houston Ave..
Longhorn Ranch Store and Grill
We stopped at the Longhorn Ranch Store and Grill in Whitesboro for lunch. It was a great experience. Best rib-eye sandwiches that we ever had. Great food and nice Western furnishings and accessories!
OTTIS AND BARBARA MURDOCK, Benbrook
Longhorn Ranch Store and Grill is at 12265 E. US 82.


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The Forresters Resort And Functio is located in The Entrance, Forresters Beach, New South Wales, Australia
- Just One Hour North Of Sydney Nsw, Forresters Beach Resort And Conference Centre Offers 4 Star Accomod- Ations And Modern Convention Facilities Set In Two Acres Of Tropical Gardens And Only 6 Minutes Walk To The Beach. - Dlx - Deluxe Guest Room With Either 1 Queen Bed Or 1 Queen Bed And Single Bed. - Std - Standard Guest Room With Either 2 Queen And 2 Singles Or A Queen And Single Bed With A Sofa Or A Queen Sofa Or A Queen Bed. - Eak - Executive Guest Room With 1 King Bed Or King Bed With Sofa. - Exc - Extremely Large Guest Room With 1 King Bed And A 2 Person Spa. - Rooms Include Air Conditioning/ Heating, Honeymoon Suite Or Over- Sized Rooms.
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Baby Nano Puff Jacket
In Stock Product Number: 32234
The thing about backcountry weather in the spring is that whatever it is, it probably won't last. The windproof and water-resistant Patagonia Baby Nano Puff Jacket Jacket handles fickle climes by combining a 1.4-oz 20-denier polyester mini-ripstop shell and a 2-oz 100% polyester plain weave, both with a Deluge DWR (durable water repellent) finish. The interior of this baby puff jacket holds ultralight, compressible 60-g PrimaLoft One insulation that has a high warmth-to-weight ratio for steady, all-day toastiness. Features: full-zip front with internal wind flap and zipper garage; zippered handwarmer pockets with reflective pulls; stay-put spandex binding at cuffs.
* This product does not qualify for shipping to all countries.
- Lightweight, wind-resistant polyester mini-ripstop shell has high-tear strength; fabric treated with a DWR (durable water repellent) finish
- Warm and incredibly lightweight insulation made of 60-g PrimaLoft ONE 100% polyester
- Unique quilt pattern holds insulation in place
- Full-zip front with internal wind flap and zipper garage; two zippered handwarmer pockets with reflective webbing pulls
- Spandex binding at sleeve opening
- Hand-me-down ID label
- Shell: 1.4-oz 20-denier polyester mini-ripstop. Lining: 2-oz 100% polyester plain weave. Both with a DWR (durable water repellent) finish. Insulation: 60-g PrimaLoft ONE 100% polyester
Gender: Youth
Weight: 161 g (5.7 oz)
Material: Polyester plain weave,Deluge DWR
Technologies: [PrimaLoft ONE]
PrimaLoft ONE
Season: F14
Vendor ProductId: 61360
Review ProductId: 32234


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A true gem. Screen printed on silk, the Nordic Diamond Silk Pillow Cover is inspired by Scandinavian patterns and ice crystals. Arrange on a sofa or bed for an instant dose of glamour.
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Laundry Organization & Laundry Room Storage
Green solutions to everyday laundry and storage problems help keep your home safe and clean. Put an ecofriendly spin on your laundry room organization with healthier washing, drying, and laundry storage products that are free of toxic chemicals.
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Mizzou put together a solid effort in 2014, reaching the bubble of the NCAA Tournament. But that's all they go to, as a 9-9 SEC record had a few losses too many to be taken seriously for national contention despite going 23-12 overall. Jabari Brown (19.9 PPG) left for the NBA Draft, Jordan Clarkson (17.5 PPG) was drafted by the Lakers, and Earnest Ross (14 PPG) graduated. No one else averaged even six points per game, and then coach Frank Haith abruptly bolted for Tulsa. A transfer comes in spring semester and a couple freshmen will debut, but otherwise this team is in serious rebuilding mode.
The Missouri Tigers operate under coach Kim Anderson at Mizzou Arena in Columbia, Missouri. The Tigers seem to go through periodic phases of success, making the NCAA Tournament every year between 2009 and 2013, but not between 2003 and 2009, but then every year from 1998 through 2003. Overall they've made 26 Tournament appearances, seven Sweet Sixteens (most recently in 2009), and sent 26 players to the NBA including Larry Drew, Linas Kleiza, Anthony Peeler, and Keyon Dooling. Mizzou looks to start another run of consistent success this season, and Gold Coast Tickets want to help get you in the stands to see it!
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SACRAMENTO – Assemblywoman Shannon Grove (R-Bakersfield) Monday recognized Little Deer Durvin as the 34th Assembly District's "Woman of the Year." Durvin, a Ridgecrest resident, is best known in her community as a beloved child care provider and advocate for child education. She owned and operated Little Deer's Family Child Care and Preschool for nearly 25 years."It's such a pleasure to be recognized for doing the work that I...
News to knowAccording to a report from USA Today, officials have identified a man who bought two tickets...
Hot videoAn outdoorsman's video shows just how far a hungry bear will go for a snack in this viral video of a black bear climbing up a tree and out onto a wire in an attempt to grab a snack.
You can tell it�s Lent without going to church:� Groceries are packed with seafood and coupon deals.
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M&H Racemaster
M&H Racemaster produces top of the line tires for drag racing applications. Their signature tire is the Front Runner, which allows the use of skinny front wheels. These tires are sure to help you achieve your goals when drag racing your Ford Mustang.
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News Posts
Two of Year's Top Ten New Species Discovered by Museum Scientists
by AMNH on
Two extraordinary new species discovered by scientists at the American Museum of Natural History — a toothy leech and a Louisiana batfish — have been named in the Top 10 New Species of 2011, a ranking compiled by the International Institute for Species Exploration (IISE) at Arizona State University. Every year taxonomists at the IISE review thousands of new species uncovered over the preceding calendar year.
One of the Top 10 is Tyrannobdella rex, which means "tyrant leech king," a new species of blood sucker with ferociously large teeth lining a single jaw. It was discovered in Perú when the leech, which is less than 2 inches in length, was plucked from the nose of a girl who had recently been bathing in a river. T. rex was first brought to the attention of Mark Siddall, curator in the Museum's Division of Invertebrate Zoology, when he received a specimen collected by Dr. Renzo Arauco-Brown, a Peruvian medical doctor. Siddall immediately recognized it as a new species. Part of the research for the paper, originally published in PLoS ONE, involved an expedition by two of Siddall's students, Anna Phillips and Alejandro Oceguera-Figueroa, to gather new specimens for DNA analysis.
Frogs: A Chorus of Colors
by AMNH on
Back by popular demand, Frogs: A Chorus of Colors, opens at the Museum on Saturday, May 28. Featuring more than 200 live frogs, from the tiny golden mantella frog to the enormous African bullfrog, this dynamic exhibition introduces visitors to these complex amphibians, their biology and evolution, their importance to ecosystems, and the threats they face in the wild.
Podcast: Human Evolution and Why It Matters: A Conversation with Leakey and Johanson
by AMNH on
Celebrating decades of groundbreaking exploration in East Africa, renowned paleoanthropologists Donald Johanson and Richard Leakey shared the stage at the American Museum of Natural History recently to discuss the overwhelming evidence for evolution in the hominid fossil record and why understanding our evolutionary history is so important. In this podcast, join the discussion, moderated by Dr. Sanjay Gupta, chief medical correspondent for CNN.
Known for such landmark discoveries as "Lucy" (Johanson) and "Turkana Boy" (Leakey), the work of these two scientists has produced much of the fossil evidence that forms our understanding of human evolution.
Looking back over careers spanning 40-plus years, Dr. Johanson and Dr. Leakey shared the stories behind their monumental finds and offered a look at what's ahead in human evolutionary research.
This historic event was made possible through a joint partnership of the American Museum of Natural History, the Arizona State University Institute of Human Origins, and the Turkana Basin Institute, headquartered in the U.S. at Stony Brook University.
Museum Astrophysicist Receives Award
by AMNH on
Museum astrophysicist Jacqueline Faherty, who recently completed her doctorate under the supervision of Curator Michael Shara, was one of five students at Stony Brook University who received the 2011 President's Award for Distinguished Doctoral Students.
Faherty's dissertation looked at the kinematics of brown dwarfs—objects intermediate between planets and stars because they aren't massive enough for nuclear fusion. The award citation is:
"For creating the largest extant catalog of uniform astrometric data on brown dwarfs, and for making significant contributions to our understanding of the nature and physics of brown dwarfs based upon this astrometric data."
Name the Mamenchisaurus Contest
by AMNH on
She's new in town and she needs a name! Meet Mamenchisaurus, an 18-year-old vegetarian known for her 30-foot-long neck and for being one of the world's largest dinosaurs. She recently arrived at the American Museum of Natural History, and thousands of people have come to see her so far. Like a lot of 18-year-olds, she also happens to love tweeting. But her full name, Mamenchisaurus hochuanensis, is too long to tweet. So let's give her a nickname!


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The area on a man's body found between the scrotum and anus. Also known as "the seams of life" because if one tears his scranus his soul will fall out.
I tore my scranus and my soul fell out.
od uživatele professor nutsack 11. Srpen 2003
The flabby stinky skin between your dingleberry tree and ur tea bagger
Mom will u please stop tickeling my scranus


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Expertise = less parries/dodges = more abilities and swings that hit the target = more abilities and swings which cause damage and threat = more threat. Expertise scales fully with all other threat stats bar hit, since it influences a different yet equally important side of the mechanics than, say, AP or Block Value.
Additionally, expertise contributes to damage reduction by reducing parry haste.


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Software, Automation & Control :: Instrumentation, Automation & Control
March 1, 2014
Amrit Agarwal,
Consulting Engineer
For optimum operation, dilute-phase pneumatic conveying systems must be operated in a certain sequence. Operators should follow the design guidelines provided here, and install the right instrumentation and controls, to avoid common problems, such as pipeline plugging, equipment failure, high power consumption, product contamination and more...
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Stormwater Management / BMP Facilities Operation and Maintenance Agreement
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Saturday Science Links: October 18, 2014
Collection of the best articles of the past several weeks on science (and faith) from around the web.
The Resource Finder has powerful filtering features — check out the tutorial to learn more.
Collection of the best articles of the past several weeks on science (and faith) from around the web.
Written by BioLogos Fellow of Biology Dennis Venema, this series of posts is intended as a basic introduction to the science of evolution for non-specialists.
This entry was originally posted on February 17, 2010. In this video conversation, Jeff Schloss makes the observation that when we use the term "evolution", it is not always exactly clear what we are actually discussing unless we denote the intended usage.
The evidence suggests that God has chosen to work through a random process, one which involves the routine creation and destruction of millions of cells that never get used. This is the ordinary means by which God maintains our health. The miracles of healing recorded in the Bible are miraculous precisely because they don't occur by this normal, natural process.
The tension generated by our understanding of God's character, as revealed in the Bible, and by the reality of the natural world around us has been the focus of much debate within the Christian church since the first century. This series examines critically several of the proposed solutions to this problem, viewing them from the perspective of a geologist, paleontologist, and orthodox evangelical Christian.
In this series, we reexamine the claim made by Intelligent Design proponent Michael Behe to have found a limit to "Darwinian" evolution in light of recent results from the laboratory of Richard Lenski.
When they imagine evolution, many Christians picture novelty: new species arising over time, or speciation events. But as the most recent Southern Baptist Voices exchange makes clear, many Christians also focus on the role of death in evolution—something that can be a stumbling block.
It is one thing to say that death is primordial; it is another to view it as the central means of creation. The theological uneasiness about this issue ultimately rests not just on an understanding of God's creative activity, but also on a particular representation of evolution.
We live in exciting times for a geneticist: more and more genomes are being sequenced, and more and more novel genome-wide analyses are being performed to shed light on what all those newly-determined sequences mean.
I now respond directly to Dembski's analysis of "Darwinism" and how BioLogos differs from the view he critiques.
In science, we don't really know the true way things actually work. What we have are theories—broad explanatory frameworks supported by experimentation, which we can use to make testable predictions about the natural world.
A common challenge to evolutionary theory is that while life does indeed change over time (what is known as microevolution), no one has ever seen one species evolve into another species (macroevolution).
In today's video, Dr. Rick Colling states that evolution is not merely the imposition of death and destruction and survival of the fittest. Rather, it is about second chances.
One of the challenges for discussing evolution within evangelical Christian circles is that there is widespread confusion about how evolution actually works. In this installment on "junk DNA", we explore how genomics can be employed to test for non-functional sequences by comparing sequences between related organisms.
Scholar and musician Jeff Warren addresses the questions of how music is meaningful, and where that meaning resides, by looking at the popular ideas that musical meaning is entirely subjective to the listener and that the meaning of music can be universal. He also explores the recent trend of attempting to explain music via neuroscience. Finally, he looks into the reasons why music continues to play such a critical role in the worshiping life of the Church.
In today's video, Oxford physicist Ard Louis discusses the famous debate between renowned evolutionary biologists Stephen Jay Gould and Simon Conway Morris over the idea of evolutionary convergence.
This two-part series highlights some of the most common misconceptions about evolution and some helpful responses to them.
This blog series by Dennis Venema undertakes the task of clarifying numerous aspects of evolution that often become misconstrued by Christians. He first discusses the idea of speciation in a population over time, later applying it to the speciation process that occurred among hominids (human ancestors) which led to modern humans. He continues to support this idea by exploring so called "Mitochondrial Eve,""Y Chromosome Adam" and other compositional clues of the human genome.
With his standard panache, the late Harvard paleontologist Stephen J. Gould argued strenuously that evolution had no inherent directionality. We are mere accidents; a "tiny twig on an improbable branch of a contingent limb on a fortunate tree".


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Hey Ciderhelm its Aradin from Rivendare. I am a pally tank working on progression this week in Ulduar with The Grand Crusaders. Been watching your videos and I am really liking them. I have also been looking for better ways to optimize my game play by using new mods to help me out more. I've noticed and have most of the same mods as you, but would like to know what health bar mod your using that you can set in the middle of your screen like that showing your own and your targets health.
Get back at me whenever you can and please share any help you can provide me. Thank you very much .
Hey Cider, I'm really interested in the mod you use to show your current health pool and rage in numbers above your target and target/target
Edit: Nevermind, it was in the post right before this one. Thanks!
What was the addon used too see your health and the targets health?
My guild just downed these guys usin 3 tanks. Probably not ideal but we had 2 dk tanks and a pally tank. i tanked stormcaller by myself, and bein an unholy tank i was able to use my ghouls gnaw as an extra interrupt. So between mind freeze, strangulate, gnaw, and death grip when he was bein stubborn and wouldnt move out of the runes, it was very easy to keep him silenced almost the entire fight. the fight took a little longer bein down a dps, but overall it wasnt too tough
As a warrior tank, I open the pull with a charge and take Brundir and Molgeim. Our Paladin taunts Steelbreaker back to the entrance. It is incredibly easy for a Warrior to solo the two smaller bosses. After the initial pull, applications of Thunderclap and Demo Shout are enough to keep threat on the two while dps focus on the big guy. So During phase one, you sit back and just ready your interrupts. Shockwave, Bash, and Conc Blow work on both Chain Lightning and Whirlwind. Just be aware that Bash is your only instant there. Save Heroic Throw when he's standing in the rune and needs to be silenced.
Besides the dispel being important, having the tank strafe away from Steelbreaker is best. The mob really needs to get out of that rune fast when it appears under him. He moves somewhat slow and this doesn't help. Walking backwards is too slow and you don't want to put your back to him when he's on that rune. So set yourself up.
If ranged can stay next to the wall if at all possible, because of the death rune, it's usually helpful.
After wiping for a couple of nights in 10 man using 1 paladin tank on the smaller bosses and me (warrior) on Steelbreaker we decided to do it like this:
Paladin on Steelbreaker by the entrance (can dispell himself instantly)
Warrior on Molgeim at the back left (Shield Slam removes his shield)
Unholy DK tanks Brundir on the back right with a single resto druid healing both the warrior and the DK who takes very very little damage on this Brundir
It seems a bit overkill to do it with 3 tanks on 10 man but it works for us.
Unfortunately we had to stop early for the night due to a DC but we've got this strat nailed and are looking forward to the kill on Thursday.
As always thank you! We failed last night on this fight, but now I am going to have everyone in the raid come watch this before we go in. And as always the videos are great! Most people have to see the fight, they cant just listen and do what they are told =) tankspot is fail proof!
so i have an idea for killing these guys in diffrent orders, but i was wondering.....
Do there healths reset after each one dies, or can you get all there health down to like 5-10% and then just pick them off in what ever order u want?
Hey all!! I thought I would put in my 2 cents and forgive me if this is repeated...!
After wiping on Council about 9 times in 10 man we were wondering if the strategy above worked...we used a Warrior tank at the back on Runemaster and Stormcaller with a pally healer and I tanked Steelbreaker near the door with a holy priest on me and a drood healing grp and backing up the priest on fusion punch.
By accident on the 10th try, I pulled Steelbreaker and Runemaster and left the Warrior with the little guy. We decided to ride it out and see what would happen and holy crap was it easy!! The Warrior and his pally healer were actually bored at the back and the 2 bosses I had went down like girls. It took some cute kiting to use the blue runes to the best of our advantage but over all this was the easiest way. Give it a try!
Great video. We actually did this in a organized pug, a mixture of 2 guilds when we attempted this. However due to the fact that we wernt entirely sure what we were in store for when each council member died or how we would be able to react to it. The rune circles and the lightning tendrils specifically. We dpsd molg and brun down to roughly 25-30% and then proceeded to take down steelbreaker from 100%-0. After taking down molg we popped hero and took down brun relatively easy.
the addon that you used Hp bar for boss and seemed like yours on the right what addon would that be?
Okay, so, I know this thread is old, and I get the gist of the fight with a warrior tank. I've had several attempts made with a warrior tanking Brundir in the back, so I know how it goes.
What happens when you don't have a Warrior in the raid?
I'm leading a newly formed 10 man raid group through Uld on our way to ToC/ToGC. I've got two great pally tanks, great DPS, and working on the healers, but no Warrior to be found anywhere. Does Brundir's tank have to be defense capped? Or could I put my DPS DK in the back for a "3" tank setup? What about putting a Rogue in the back with the Pally tank, or does that kill the DPS on Stormcaller too much? I really feel like we have the interrupts between the DK, my Enhance shammy, and my Rogue, but I'm just not sure how hard Brundir hits or how quickly my DPS can down Stormcaller in the front.
Thanks in advance.
If the shaman could go Ele, and with proper placement, you could in theory have the shaman interrupting ranged while still DPSing other targets. I'd have the shaman make a macro to Windshear the Focus target (Brundir) with cast bars up.
To be honest, you can probably get away with not interrupting everything. When my guild was progressing through Ulduar we killed Brundir last, which meant I had him all to myself for the majority of the fight and it just wasn't possible to stop everything even as a warrior (well, I never got to crazy with warbringer).
The Brundir tank doesn't have to be D-capped, since he spends the majority of the time casting and if you lock him out of nature or silence him he doesn't melee for that hard (4 - 5k on plate I believe?).
But on 10-man if you have 3 healers and are killing Steelbreaker first you can afford to let a few (or more) lightning bolts get through. I would prioritize interrupting chain lightning in phase one. Then lightning whirl in phase 2 (you can't let those get through however). Remember he's stunnable and silenceable until phase 3.
I just wish some of our guildmates had more patience. The grumbling starts after 2 wipes, and bailout is widespread after 3. Any suggestions on that?
I'm an alt-oholic. I'm ok with that.
Well our guild never had a warrior for any runs sofar in ulduar and it worked quite fine.
The strategy we use is 1 tankadine takes steelbraker at the entrance and the other tankadine gets the other 2 bosses in the back. He interrupts what he can, we get steelbreaker quickly down, i take molgein (forgot how to write it again we down him paying special attention to the green runes.
Than finaly we all go on brundir and our dk heps a lot with the interrups.
What might work is using a fellhunter for the interrupts on brundir
I'm an alt-oholic. I'm ok with that.