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New Data on Vortioxetine for Cognition in Unipolar Depression
A 5mg dose of the antidepressant vortioxetine (Brintellix) was previously reported to have positive cognitive effects in elderly depressed patients. In a 2014 article in the International Journal of Neuropsychopharmacology, researcher Roger S. McIntyre et al. presented data from FOCUS, a study of cognition in depressed patients. The eight-week double-blind study included 18- to 65-year-olds (who were not selected for having cognitive problems per se).
McIntyre and colleagues used two tests of cognition, the Digit Symbol Substitution Test (DSST), which measures attention, psychomotor speed, and executive function, and the Rey Auditory Verbal Learning Test (RAVLT), which measures memory and acute and delayed recall. The researchers found that both the 195 patients taking 10mg/day of vortioxetine and the 207 patients taking 20mg/day of vortioxetine had better performance on both tests than the 196 patients who received placebo.
Response rates (meaning a patient achieved a 50% improvement on a scale of depression) were 47.7% on 10mg of vortioxetine, and 58.8% on 20mg of vortioxetine, compared to 29.4% on placebo. Remission rates were 29.5% on 10mg of vortioxetine and 38.2% on 20mg of vortioxetine versus 17% on placebo. McIntyre suggested that the drug worked both directly and indirectly, improving depression in some, but also improving cognition even in those whose depression did not improve.
The mechanism that could account for vortioxetine's cognitive effects has not yet been identified. Like other selective serotonin reuptake inhibitor (SSRI) antidepressants, vortioxetine is a potent blocker of serotonin (5HT) reuptake, which it does by inhibiting the serotonin transporter (5HT-T). Unlike other SSRIs, vortioxetine is also a blocker of 5HT3 and 5HT7 receptors, an agonist at 5HT1A and 5HT1B and a partial agonist at 5HT1D receptors. It could be considered a polymodal 5HT active drug in contrast to the more selectively active 5HT-T–inhibiting SSRIs.
Lighting Up Neural Networks in Mice
A new technology is making it possible to view the mammalian brain's structure and connectivity for the first time. Karl Deisseroth discussed the technology, called CLARITY, at a plenary lecture at the 2014 meeting of the International College of Neuropsychopharmacology.
The way CLARITY works is by replacing lipids in the brain with a hydrogel substance. This preserves the structure of the brain's neural networks, leaves proteins and nucleic acids intact, but allows for observation by rendering the brain transparent. This can be done in a system as large as the entire adult mouse brain. Early attempts took a whole day, but Deisseroth eventually found a way to render a mouse's brain transparent in a matter of minutes.
The pictures are truly amazing, allowing for the visualization of previously microscropic neurons, dendrites, axons and connections in life-sized images. Pictures and details are available at www.clarityresourcecenter.org.
Deisseroth and colleagues have used CLARITY imaging to determine where neurons fire during different social activities. By placing photosensitive fibers in selected neurons using a virally based gene insertion technique, Deisseroth and colleagues were able to selectively fire dopamine neurons in the ventral tegmental area, part of the brain's reward system, and thus increase or decrease the social interaction of mice by increasing or decreasing firing. The effects were selective to social interaction; the firing did not affect locomotor activity or exploration of an inanimate object.
The ventral tegmental area contains neurons that project to several locations in the brain, and Deisseroth and colleagues hoped to observe which were important to social interaction. Stimulating the ventral tegmental area to drive the medial prefrontal cortex caused anxiety in the mice and made them averse to social interaction. However, when the ventral tegmental area was used to selectively drive the nucleus accumbens, another part of the brain's reward system, social interaction increased.
Deisseroth wanted to know if the nucleus accumbens was also involved in normal spontaneous social interactions. The researchers used a virus to insert an opsin-sensitive calcium gene that could give an ongoing readout of neural activity. (Opsin is a light-sensitive receptor found in cells in the retina.) The team found that the nucleus accumbens was implicated in social interaction with another mouse, but not in exploration of a novel object. Based on CLARITY imaging of the structure of ion channels (which are so small they cannot even be seen with an electron microscope), Deisseroth was able to selectively alter ion fluxes and turn neuronal firing on or off at will.
In the last 50 years, the brain and its billions of neurons and hundreds of trillions of synapses have gone from complete inaccessibility toward increasing clarity.
Rapid-Onset Antidepressant Treatments
At the International College of Neuropsychopharmacology (CINP) World Congress of Neuropsychopharmacology in 2014, several presentations and posters discussed treatments that bring about rapid-onset antidepressant effects, including ketamine, isoflurane, sleep deprivation, and scopolamine.
Ketamine's Effects
Multiple studies, now including more than 23 according to researcher William "Biff" Bunney, continue to show the rapid-onset antidepressant efficacy of intravenous ketamine, usually at doses of 0.5 mg/kg over 40 minutes. Response rates are usually in the range of 50–70%, and effects are seen within two hours and last several days to one week. Even more remarkable are the six studies (two double-blind) reporting rapid onset of antisuicidal effects, often within 40 minutes and lasting a week or more. These have used the same doses or lower doses of 0.1 to 0.2mg/kg over a shorter time period.
Attempts to sustain the initial antidepressant effects include repeated ketamine infusions every other day up to a total of six infusions, a regimen in which typically there is no loss of effectiveness. Researcher Ronald Duman is running a trial of co-treatment with ketamine and lithium, since both drugs block the effects of GSK-3, a kinase enzyme that regulates an array of cellular functions, and in animals the two drugs show additive antidepressant effects. In addition, lithium has been shown to extend the acute antidepressant effects of one night of sleep deprivation, which are otherwise reversed by a night of recovery sleep.
Ketamine's effects are related to the neurotransmitter glutamate, for which there are several types of receptors, including NMDA and AMPA. Ketamine causes a large burst of glutamate presumably because it blocks NMDA glutamate receptors on inhibitory interneurons that use the neurotransmitter GABA, causing glutamatergic cells to lose their inhibitory input and fire faster. While ketamine blocks the effects of this glutamate release at NMDA receptors, actions at AMPA receptors are not blocked, and AMPA activity actually increases. This increases brain-derived neurotrophic factor (BDNF), which is also required for the antidepressant effects of ketamine. Ketamine also increases the effects of mTOR, a kinase enzyme that regulates cell growth and survival, and if these are blocked with the antibiotic rapamycin, antidepressant effects do not occur.
In animal studies, ketamine increases dendritic spine growth and rapidly reverses the effects of chronic mild unpredictable stressors on the spines (restoring their mature mushroom shape and increasing their numbers), effects that occur within two hours in association with its rapid effects on behaviors that resemble human depression.
About 50–70% of treatment-resistant depressed patients respond to ketamine. However, about one-third of the population has a common genetic variation of BDNF in which one or both valine amino acids that make up the typical val-66-val allele are replaced with methionine (producing val-66-met proBDNF or met-66-met proBDNF). The methionine variations result in the BDNF being transported less easily within the cell. Patients with these poorly functioning alleles of BDNF are less likely to get good antidepressant effects from treatment with ketamine.
Ketamine in Animal Studies
Researcher Pierre Blier reviewed the effects of ketamine on the neurotransmitters serotonin, norepinephrine, and dopamine. In rodents, a swim stress test is used to measure depression-like behavior. Researchers record how quickly the rodents give up trying to get out of water and begin to float instead. Blier found that ketamine's effects on swim stress were dependent on all three neurotransmitters. For dopamine, ketamine's effects were dependent on increases in the number of dopamine cells firing, not on the firing rate, and for norepinephrine, ketamine's effects were dependent on increases in burst firing patterns. Each of these effects was dependent on glutamate activity at AMPA receptors. Given these effects, Blier believes that using ketamine as an adjunct to conventional antidepressants that tend to increase these neurotransmitters may add to its clinical effectiveness.
Important Anecdotal Clinical Notes
Blier reported having given about 300 ketamine infusions to 25 patients, finding that two-thirds of these patients responded, including one-third who recovered completely, while one-third did not respond to the treatment. Patients received an average of 12 infusions, not on a set schedule, but according to when they began to lose response to the last ketamine infusion. If a patient had only a partial response, Blier gave the next ketamine treatment at a faster rate of infusion and was able to achieve a better response. These clinical observations are among the first to show that more than six ketamine infusions may be effective and well tolerated. Read more
Saffron Is An Effective Treatment for Mild Depression
Saffron, the expensive yellow spice derived from the plant Crocus sativus, was the subject of a recent meta-analysis in the journal Human Psychopharmacology. The meta-analysis included six studies of a total of 230 adult outpatients with major depressive disorder. In two of these studies, 30mg/day of saffron extract was as effective as 20mg/day of the antidepressant fluoxetine and 100mg/day imipramine for the treatment of mild to moderate depression had been in other studies.
Saffron is suggested to have anticancer, anti-inflammatory, antioxidant, and antiplatelet effects, and current clinical trials are exploring whether it could prevent and treat Alzheimer's disease.
The current study was an effort to systematically analyze clinical trials on saffron to establish treatment parameters such as dosage in addition to safety information.
Study Finds No Substantial Risk of Infant Cardiac Problems from Antidepressant Use During Pregnancy
In the past there has been some concern that selective serotonin reuptake inhibitor (SSRI) antidepressants taken during pregnancy could increase an infant's risk of cardiac problems. There was particular concern that the SSRI paroxetine could lead to right ventricular outflow tract obstruction, and sertraline could lead to ventricular septal defects. A 2014 study by KF Huybrechts et al. in the New England Journal of Medicine analyzed data from 949,504 women in a Medicaid system from three months before pregnancy until one month after delivery during the years 2000-2007.
Infants born to mothers who had taken antidepressants during their first trimester were compared to infants whose mothers had not taken antidepressants. In total, 6.8% or 64,389 women had used antidepressants in their first trimester.
While the rate of cardiac defects in newborns was greater among those mothers who had taken antidepressants (90.1 infants per 10,000 infants who had been exposed to antidepressants versus 72.3 infants per 10,000 infants who had not been exposed to antidepressants), this relationship diminished as confounding variables were removed. The relative risk of any cardiac defect after taking SSRIs was 1.25, but this decreased to 1.12 when restricted to only those mothers who were diagnosed with depression, and to 1.06 when the researchers controlled for things like depression severity. (All relative risk numbers were calculated with a 95% confidence interval.)
The researchers concluded that there is no substantial risk of increased cardiac defects in children born to mothers who took antidepressants during their first trimester.
The Good and Bad News About Deep Brain Stimulation for Treatment-Resistant Depression
Deep brain stimulation is a treatment in which electrodes are implanted in the brain to treat movement or affective disorders. At the 2014 meeting of the International College of Neuropsychopharmacology, Thomas Schlaepfer reviewed the current status of studies of deep brain stimulation for depression. The bad news is that two double-blind randomized controlled studies are no longer recruiting patients because interim analysis failed to show a benefit to the deep brain stimulation over a sham stimulation. The studies targeted two of the most promising parts of the brain for deep brain stimulation—the subgenual anterior cingulate (important for motivation) and the anterior limb of the internal capsule (which contains nerve fibers going to and from the cerebral cortex), so their failure is a big disappointment.
The better news is that Schlaepfer repositioned the electrodes to target a site in the medial forebrain bundle nearer to the ventral tegmental area. After this shift he observed rapid onset of antidepressant response (within two days) in seven of the first eight patients studied, and these responses persisted over many months of follow up. This response was achieved at 2.8 microamps, a lower stimulation current than was used in other studies of deep brain stimulation.
Editor's Note: Since patients started to feel better when they were still on the operating table, this may offer an opportunity to more rapidly assess effectiveness, do a double-blind study, and see if the findings can be replicated as another mode of achieving rapid-acting and long-lasting antidepressant effects in treatment-resistant patients. Intravenous ketamine has rapid-onset antidepressant effects, but its effects are short-lived.
Antidepressants and Ketamine Reverse Animal Models of Anhedonia and Learned Helplessness
Researcher Tony Pitts presented a study at the 2014 meeting of the International College of Neuropsychopharmacology (CINP) that described the neurobiology of an animal model of depression in rodents. In animal models, researchers provoke depression-like symptoms in animals with the hopes of finding neurobiological clues to human depression. Pitts' studies explored the effects of acute stressors as well as more chronic long-term stressors such as learned helplessness.
In the rodents, acute stressors caused increased cell firing in the hippocampus, which caused increases in burst firing and an increase in the number of cells firing in the ventral tegmental area, which then led to increased activity in the nucleus accumbens (the brain's reward center). However, after the stressor was over, there was an opponent process that resulted in a much more prolonged period of inhibition in the nucleus accumbens, with associated decreases in psychomotor activity and reward seeking. The rodents lost their preference for sucrose and engaged in less intracranial self-stimulation, pressing a bar to stimulate the brain pleasurably. These and other effects suggest an analogy to anhedonia (loss of pleasure in activities that were previously enjoyed), which is a key component of human depression.
In related studies, after experiencing periods of inescapable shocks, rodents developed learned helplessness, failing to avoid the area where shocks were delivered even when an exit was readily available. Rodents who had learned helplessness showed inhibited firing of cells in the ventral tegmental area, less activity in the nucleus accumbens, and apparent anhedonia. This inhibition was mediated via messages from the infralimbic prefrontal cortex (the equivalent to the subgenual cingulate cortex in humans, important for motivation) to the amygdala and then the GABAergic ventral pallidum, which decreased the number of dopaminergic cells firing in the ventral tegmental area. Blocking the amygdala input to this inhibitory pathway reversed the low dopamine firing and the anhedonia-like behaviors.
The anesthetic ketamine (which has rapid-acting antidepressant effects in humans) produces an immediate reversal of the learned helpless behavior in the rodents and increases the number of dopamine cells firing in the ventral tegmental area. Ketamine administered directly into the nucleus accumbens induces long-term potentiation (enhanced synaptic responsivity) and reverses helpless behavior and the long-term depression of neural firing that is associated with it.
Thus, when an acute stressor is over and the opponent process emerges, or following long-term chronic stressors such as learned helplessness, the excitatory path to the ventral tegmental area is absent, while the inhibitory path to the ventral tegmental area (via the infralimbic prefrontal cortex, amygdala, and ventral pallidum) predominates. Ketamine is able to re-activate the activating pathway and increase activity in the ventral tegmental area and the nucleus accumbens, changes that are associated with the reversal of learned helplessness and anhedonia.
Editor's Note: In the previous BNN, we reported researcher Scott Russo's findings that input from the intralaminar nucleus of the thalamus was critical to the depression-like behaviors seen in a different animal model of depression, social defeat stress, where repeated exposure to defeat by a larger, more aggressive animal produces behaviors that resemble human depression. Here in Pitts' research, learned helplessness is induced by inescapable shocks. Both models share the finding that firing decreases in the reward area of the brain (the nucleus accumbens). However, the key part of the brain driving the low levels of activity in the nucleus accumbens and the associated depression-like behavior appear to be different in these two different models. The intralaminar nucleus of the thalamus plays a key role in the social defeat stress model, while the infralimbic cortex and the amygdala play key roles in the learned helplessness model. These data together suggest that part of the reason depression differs from person to person may be because the illness can be driven by different brain areas as a result of different kinds of stressors.
Antidepressants and Ketamine Induce Resilience in Animals Susceptible to Depression-Like Behavior
To study depression in humans, researchers look to rodents to learn more about behavior. Rodents who are repeatedly defeated by more aggressive animals often begin to exhibit behavior that resembles depression. At the 2014 meeting of the International College of Neuropsychopharmacology (CINP), researcher Andre Der-Avakian reported that in a recent study, repeated experiences of social defeat led to depressive behavior in a subgroup of animals (which he calls susceptible), but not in others (which he calls resilient). Among many biological differences, the resilient animals showed increases in neurogenesis in the dentate gyrus of the hippocampus.
Chronic treatment of the susceptible animals with the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine or the tricyclic antidepressant desipramine, which both increase neurogenesis, also reversed the depressive behavior in about half of the animals. A single injection of the anesthetic ketamine (which has rapid-acting antidepressant effects in humans) reversed social avoidance behavior in about 25% of the animals. One depression-like symptom was anhedonia (loss of pleasure from previously enjoyed activities), which researchers measured by observing to what extent the animals engaged in intracranial self-stimulation, pressing a bar to stimulate the brain pleasurably. The effectiveness of the drugs in inducing resilient behavior was related to the degree of anhedonia seen in the animals. The drugs worked less well in the more anhedonic animals (those who gave up the intracranial stimulation more easily, indicating that they experienced less reward from it.)
Atypical Antipsychotics in Bipolar Depression
A limited number of atypical antipsychotics are approved by the Federal Drug Administration for the treatment of depression in patients with bipolar disorder. This is important to note, because the widely used traditional antidepressants that are highly effective in unipolar depression are not effective in bipolar depression. Here we review the status of the only three approved drug treatments for bipolar depression (olanzapine, quetiapine, and lurasidone) and highlight data on a promising new atypical antipsychotic, cariprazine.
Lurasidone (Latuda)
At the 2014 meeting of the International College of Psychopharmacology, researcher Joseph Calabrese reviewed the efficacy of the latest atypical antipsychotic to receive FDA approval for bipolar depression, lurasidone. In monotherapy, both low (20–60mg/day) and high doses (80–120mg/day) showed higher response rates (53% and 51%, respectively) than placebo (30%). When added to either lithium or valproate, lurasidone response (57%) again exceeded that of placebo (42%). Calabrese also indicated that all of the other secondary outcome measures were also statistically significant, including score on the Clinical Global Impressions scale for bipolar disorder, time to response, percentage of remitters, time to remit, score on the Hamilton Anxiety scale, and a patient rated depression scale (QIDS).
Lurasidone is also approved for schizophrenia at higher doses (up to 160mg/day). At least twice as much of the drug is absorbed when food is in the stomach, so it is recommended that patients take it one to two hours after dinner or after a snack of 350 calories or more. The drug has an excellent side effects profile, as it is weight- and metabolically- neutral (i.e. it does not increase blood glucose, cholesterol, or triglycerides).
Quetiapine (Seroquel)
The atypical antipsychotic quetiapine has been FDA-approved for bipolar depression for a number of years. It consistently performs better than placebo in bipolar depression, and unlike lurasidone, quetiapine is also FDA-approved for mania, as well as for long-term prevention of both manic and depressive episodes as an adjunct to either lithium or valproate. Quetiapine is also superior to placebo for prevention of both manic and depressive episodes as a monotherapy, but is not FDA-approved for this indication. A good target dose for bipolar depression is 300mg/day of the extended release preparation taken several hours prior to bed time. Higher doses of 400 to 800mg/night are used for mania and schizophrenia. Quetiapine is also FDA-approved as an adjunct to antidepressants in unipolar depression. The drug has sedative side effects, perhaps because of its potent antihistamine effects. It can also increase weight, glucose, and cholesterol slightly more than placebo.
Olanzapine and Fluoxetine
Olanzapine (Zyprexa) and a combined preparation of olanzapine and fluoxetine (Symbyax) are also approved for bipolar depression, but many guidelines suggest that these be considered secondary treatments because they are associated with weight gain and adverse metabolic effects.
Cariprazine Effective in Bipolar Depression and Mania
At the 2014 meeting of the International College of Neuropsychopharmacology, researcher Suresh Durgam presented a poster on the first study of the atypical antipsychotic cariprazine in bipolar depression. There have also been three positive placebo-controlled studies of the drug in mania. It is a dopamine D2 and D3 partial agonist, with greater potency at the D3 receptor than the atypical antipsychotic aripiprazole (Abilify). In the large placebo-controlled eight-week study, doses of 1.5mg/day were superior to placebo, but higher (3mg) and lower doses (0.75mg) were not.
Another poster presented by the same research group also reported that augmentation of antidepressants with cariprazine in unipolar depression had results that were significantly better than placebo.
Editor's Note: While all atypical antipsychotics that have been tested for mania have antimanic efficacy (lurasidone has not been studied in mania), their antidepressant profiles differ considerably. Only the three atypical antipsychotics noted above (olanzapine/fluoxetine, quetiapine, and lurasidone) are FDA-approved for bipolar depression, and in light of recent findings, cariprazine is likely to follow soon.
The atypical antipsychotics NOT approved for bipolar depression include: aripiprazole (Abilify), risperidone (Risperidol), and ziprasidone (Geodon), with the first atypical antipsychotic clozapine and the most recent ones not yet formally tested as far as this editor is aware, including asenapine (Saphris), iloperidone (Fanapt), and paliperidone (Invega).
Only the atypical antipsychotics aripiprazole and quetiapine are FDA-approved as adjunctive treatments to antidepressants in unipolar depression, and cariprazine may soon be added to this list.
How the Chemicals in Marijuana Work in the Brain
Raphael Mechoulam, who first synthesized THC, the main ingredient in marijuana, gave the history of marijuana and its receptors in the central nervous system in a plenary talk at the 2014 meeting of the International College of Neuropsychopharmacology. In Syria hundreds of years ago the drug was named ganzigunnu, meaning "the drug that takes away the mind." It has also been called azalla, meaning "hand of the ghost." Among the 100 compounds in marijuana, the best-known ingredient is delta-9-tetrahydrocannabinol (delta-9 THC), which produces most of the actions of the drug. There is another active ingredient, cannabidiol (CBD), which has calming and anti-anxiety effects, but is present in very low levels.
The brain has cannabinoid receptors that respond to ingredients in marijuana in addition to other chemicals produced in the brain. They modulate calcium ions and decrease the release of many neurotransmitters.
THC acts at CB-1 receptors, producing the high. The CB-1 receptor is synthesized on demand, post-synaptically, and is transferred to the pre-synaptic terminal where it decreases calcium and transmitter release. Consistent with marijuana's appetite-stimulating properties ("the munchies"), if the CB-1 receptor is blocked in animals, they lose their appetite and die of hunger.
There are also low levels of CB-2 receptors in the brain, whose activation does not cause a high, and whose levels may increase dramatically in pathological situations. Activation of the CB-2 receptor is anti-inflammatory and, in the same way that the immune system acts against foreign proteins, CB-2 acts as a protector against non-proteins.
CBD does not bind to any cannabinoid receptors, but its actions are blocked by cannabinoid antagonists.
There are two chemicals in the brain (endogenous ligands) that act at cannabinoid receptors—anandamide and 2-arachidonoylglycerol (2-AG). They are soluble only in lipids (not in water), and have never been given to people. In animals, 2-AG has neuroprotective effects, decreases the size of a stroke by 60%, and increases recovery from stroke.
Marijuana and CBD in particular have also had beneficial effects in people. Marijuana decreases the nausea and vomiting associated with chemotherapy in children, has anti-inflammatory effects in rheumatoid arthritis (decreasing inflammatory marker TNF alpha), and has anti-diabetes and anti-convulsant effects.
In 2012, researcher F. Markus Leweke and colleagues showed that CBD was about as effective as the atypical antipsychotic amisulpiride in alleviating the psychotic symptoms of schizophrenia. CBD's other effects include reducing anxiety and improving psoriasis by increasing DNA methylation (Pucci et al. 2013).
It seems possible that some of these myriad effects of marijuana and endogenous ligands at CB receptors could be exploited for clinical therapeutics, as Mechoulam endorses, but when and how that will take place remains an unanswered question.
Editor's Note: Despite all these potential positives of CBD, it should be noted that its levels are very low in marijuana, and that heavy smoking of marijuana has substantial adverse effects. These include low motivation, a doubling of the risk of psychosis, a hastening of the onset of bipolar disorder and schizophrenia, and cognitive impairment, as well as some changes in brain structure seen via magnetic resonance imaging (MRI). It may be becoming legal in many states, but is a bad idea for those at high risk for mood, anxiety, or bipolar disorders or for schizophrenia.


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Middle School News
Rittman Winter Spirit Wear
Orders for Christmas need to be in by November 25th!
Feed Those in Need
Annual Canned Food Drive
Sponsored by Quest and Tribal Council
Dec 1-5
Drop off Canned Food Items to the stage area in the commons each morning!
RMS Girls Basketball Games
7th Grade Girls Basketball will scrimage Kingsway on November 25th at Kingsway. Time of scrimage is 5:00pm.
The 8th Grade Girls Basketball scrimage with Central Christian that was canceled on November 18th is resceduled for November 25th at 4:30pm at Central Christian School.
Information PARCC Tutorials for Parents and Students
PARCC Tutorial General Overview of Toolbar
PARCC Tutorial Grades 6-8 Math Assessment Overview
PARCC Tutorial Grades 6-8 ELA Assessment Overview
MS Christmas Dance
Rittman Middle School will hold a dance on December 19, 2014 from 5pm to 7pm. Cost will be $5.00 per person. After the dance you may walk over to attend the Rittman High School Boys Basketball Game. Dance will be semi formal. More information to come.
Rittman DC Poinsettia Fundraiser
Poinsettia orders will be delivered to Heather Ramsier's house, 14994 Decourcey St. on Dec 2nd. You may pick up your orders between noon and 6pm!
CASH COW Fundraiser
Any Cash Cow money and unsold books should be returned to Diane Stuart. Any questions call Diane at 330-416-4383.
Parents Plus
Please join: Parents Plus.
Follow us on Twitter
Looking for a way to keep up with daily school events and sports? Follow us on TWITTER! @RHSRMSNews

subset: commoncrawl


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Despite the mainstream media's doom-and-gloom predictions of a deeprecession, the large number of interesting (and in some cases,innovative) products displayed at the 2001 Summer NAMM show inNashville, TN, seemed to indicate otherwise. By the end of thethree-day trade show, the editors at EM felt that a number ofitems stood out from the crowd.
TheBoss WP-20G Wave Processor is a scaled-down version ofRoland's V-Guitar processors. The stomp-box sized device acceptssignals from guitars equipped with divided pickups (with 13-pinconnectors) and issues synthesizer-like sounds, ring-mod effects, asitar-type sound, and an acoustic guitar simulation. There is no MIDIinvolved, and tracking is immediate, accurate, and above all,polyphonic. . . The JoeMeek MQ1 integrates the company'scompressor and EQ technology with a digital-audio interface for Windowsand Macintosh computers. The interface offers a breakout XLR connector andprovides 48V phantom power for use with condenser mics You also get apair of stereo, balanced 1/4-inch inputs and outputs. The breakout boxsports controls for the 3-band Meequalizer and a JoeMeek opticalcompressor. . . ToneWorks Pandora PXR4 squeezes four tracks ofhigh-quality MPEG digital audio, along with eight virtual tracks perchannel, onto SmartMedia cards. The diminutive pocket studio offers 77different effects—including amp and mic simulators— alongwith 55 sampled rhythm patterns. Editing features include Copy, Insert,Erase, Time Compression/Expansion and more. Each SmartMedia card canstore up to 99 songs. . . Eventide's new Eclipse deliversquality pitch shifting, reverb, and special effects with roughly fivetimes the processing power of its acclaimed H3000 series processor, butfor considerably less cash than it's predecessor. TheEclipse's dual-engine architecture provides serial, parallel,stereo, or dual-mono processing configurations. The Eclipse boasts24-bit, 96 kHz A/D converters, with a signal-to-noise ratio of betterthan 104 dB. . . Big Briar's long-awaited Minimoog Voyagerwill finally see the light of day. The instrument combines a polyphonicMIDI keyboard controller with a monophonic analog synth that offersthree oscillators, a dedicated LFO, and two lowpass Moog-style filters.The front panel includes a Tactex pad for use as a 3-D programming andperformance interface. MIDI I/O and a host of dedicated CV jackscomplete the scene. . . The Etek Dynamagic two-channelcompressor offers dual-band compression with an adjustable crossoverfrequency for each channel. You can adjust each channel for fast orslow release times, and the unit provides a VU meter for keeping an eyeon your signal. . . Evolution's MK-261 is an inexpensive61-key, touch-sensitive MIDI keyboard controller. The MK-261 includesassignable modulation and pitch-bend wheels, as well as transpose,octave-shift, and ten non-volatile memory locations for storing yourkeyboard setups. . . Audio-Service's D.A.I.S. is aconfigurable digital-audio patch bay that uses Yamaha YGDAI interfacecards to provide digital I/O. The rack-mountable routing systemprovides interchange between AES/EBU, ADAT, and TDIF formats, andYamaha's Y2 cards. Software for Windows and Macintosh computerslet you arrange routings graphically. . .The Mobile I/O 2882 isa FireWire digital-audio interface for Macintosh and Windows computers.The rear panel of the interface supports 24-bit, 96 kHz recording withsimultaneous balanced and unbalanced analog I/O as well as ADAT, S/PDIFoptical, AES/EBU digital, and of course, IEEE 1394 I/O. . . Rolandcombines the synthesis capabilities of its XV-series synths with avariable arpeggiator and rhythm-track generator in the new FantomWorkstation. You can control arpeggiator performances and patches onthe Fantom in real time using the onboard D-Beam controller. As withthe XV-series keyboards, the Fantom's sound set is expandable:you can increase the unit's waveform collection to over 200 MB ofsounds. . . Yamaha's AW2816 Portable Digital Studiooffers 16 mono and 1 stereo track of 16- or 24-bit audio at samplingrates of 44.1 or 48 kHz. The recorder offers an 02R-like mixer, similarto that of the AW4416, but with improved effects processing. TheAW-2816 improves upon the MIDI implementation of its predecessor withMIDI control of its motorized faders among other upgrades.
These are my comments.
Line 6 Introduces AMPLIFi TT Bluetooth Streaming System for Guitar
Amptweaker Announces Limited-Edition BluesFuzz Pedal
Nathan East Premieres New Documentary and Discusses "Footloose"
Tal Wilkenfeld Releases Christmas Single, Launches YouTube Channel
Eventide announces H9 Max harmonizer stompbox
Modartt releases Michelstone toy piano instrument for Pianoteq
Johnny A. Reveals His Gorgeous Gibsons, Gretsches & More
Jimmy Page Visits 'Ellen DeGeneres Show,' Discusses Possibility of Led Zeppelin Reunion
Win Tickets to See Opeth and In Flames Live in Los Angeles
Guitarist Chris Broderick and Drummer Shawn Drover Quit Megadeth
A Songwriter's Story: "Thanksgiving Prayer"
The Safety Fire Share Acoustic Version of "Wise Hands"
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Rumors Pointing to September iPhone 5 Ship Date 93
from the hang-in-there-kathleen dept.
Originally rumors had stated that the iPhone 5 had already started production back in March
But these new rumors are definitely accurate!
I wonder if you'll be able to
I wish Richard Stallman could turn up and defend my corner on this one...
You probably have a rounded corner. If he showed up, you could be both be sued for violating Apple's design patents. Try using a perfect, 90 degree corner.
Then say "Linux" three times and he'll show up to correct you that it should be "GNU/Linux." That's how you summon him, right?
Business is a good game -- lots of competition and minimum of rules. You keep score with money. -- Nolan Bushnell, founder of Atari


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text:
- Escape from the
- Amanda Seyfried
- Youngster Room
- The Cowboy Esca
- My Self
- Strange House E
- Escape from Stu
- House Arrest Es
- Escalator Fun
- Uno Card Game
- Ghost Bastards
- Minion Jump Adv
- Madagascar 3 Pu
- Baby Hazel Than
- Find The Object
- Thanksgiving Ch
- Lovers Drive
- Pig Wars
- Dora Barn Activ
- Teen Girl Escap
- 101 Dalmatians
- Snow White and
- Thief Escape
- Fast Sniper 2
- Zombie Physics
- Ice Room Escape
- Serving Cookies
- Girl Trap Escap
- Cheese Hunt 2
- Mr Cube
- Escape from Tha
- Puzzle Prince
- Humaliens Battl
- Jennifer Lopez
- Magicians Trap
- Escape from Sou
- Kiss Evolution
- Trouble in Pixi
- Sophisticated H
- Gold Miner
Adults Kids Top 10 Games
Escape from Wicked
Emergency Drive
Turbo Puzzle
Ninja Ladder War
Fruits Mahjong
Escape from the Al
Escape My Puzzle
Jerry Cheese Chase
Animals Word Searc
Solve the Traffic
The 490th escape game from 123bee.com Every night I hear some strange noise from my neigh...
It's an Emergency call!! You must reach the place of holocaust as fast as possible to resc...
You need to find and place the correct pieces on the empty places. If you drag the wrong o...
Are you game skilled???? Checkout this arduous game its tough enough to finish off, have a...
A Classic Mahjong game to entertain you. The goal of this game is to match the open pairs ...
The 485th escape game from 123bee.com On expedition of new worlds, aliens found our planet...
Hi Friends, we come with tricky puzzle for you. Solve this puzzle to test your brain power...
Help the Jerry to reach home before caught with Tom. Get ready for a cheese chase with all...
Hi! This is new type of word search. Find out the animals name.Click on the starting lette...
Solve the Traffic is an interesting and addictive puzzle game. Your car got stuck in this ...
Resplendent Girl D
Scooby Shadow Race
Woody to the Rescu
Cute Geeky Girl Ma
Thai Green Chicken
Barbie Arabic Prin
Womens Day Recipe
Womens Day Makeove
Princess Castle Ca
Youda Farmer 3
Here is a pretty girl, she is packing dresses to go for a vacation trip. She is confused t...
Scooby has a new challenge now! He has to race with his shadow to win the game. Use spaceb...
Help Woody getting to the other side by jumping with the rope....
Girls, being smart is an amazing quality that can be extremely helpful in life. And so is ...
Learn how to cook a delicious thai green chicken curry and follow all the step to make you...
Barbie has changed her fashionista American life style for the Arabic fashion and life sty...
Do you like to make cake on your own? Then try this cake recipe, it's very simple and enjo...
Help this women to look pretty by making facial and pick out the best dress and accessori...
Did you ever get a princess castle cake for your birthday? You will probably want a cake l...
Manage your farm goods once again as you haul your fresh supplies around town....
Walkthrough for Baby Escape
The 21st escape game from 123bee
A baby is trapped in a locked room.You can use objects and clues available here to escape.Use your intelligence to help the baby to escape
A baby is trapped in a locked room.You can use objects and clues available here to escape.Use your intelligence to help the baby to escape
Baby Escape Walkthrough: http://www.123bee.com/play/baby-escape
1.Go to left side.
2.Take the matchstick from ground.
3.Again, go to left side.
4.Take the matchbox from ground.
5.Go to right side.
6.On a slab, there is a Metal rod.
7.Take the metal rod.
8.Take matchbox from inventory panel and light up a match stick.
9.Take the matchstick and view the room through the window.
10.Come back and take the metal rod from inventory.
11.Use metal rod to on the switch.
12.Room lights are on now.
13.Go to right side twice.
14.Take the thread from ground.
15.Come back to main view.
16.There is a balloon in the umbrella hook.
17.Take the balloon.
18.Take the balloon from inventory panel and tie it with thread.
19.Take the balloon from inventory and show it to baby through window's third bar.
20.The baby comes near to the balloon.
21.Go to main view.
22.Kick the door thrice.
23.The door opens.
Walkthrough Video
Baby Escape Video Walkthrough:


text:
Local Sports
Acadiana Travels To Carencro For Big District Showdown – Game Preview
Saints Beat Up Panthers 28-10, Take Division Lead
Saints K Shayne Graham Named NFC Special Teams Player Of The Month
Five Intriguing Games This Weekend – From the Bird's Nest
High School Football Team Wins In Incrdeible Fashion – VIDEO
Saints Travel To Take On Panthers
Giants Defeat Royals, 3-2, Win World Series – VIDEO
70 Seconds Of Saints, Week 9 – Thursday Night Throw Down – With Steve Wiley [Video]
The New Orleans Saints are coming off their best performance of the season. Can they bottle that success, take it on the road, and capture a much needed road victory on a short week? There's only one man to ask. Super Saints fan Steve Wiley is back with his Week 9 edition of 70 Seconds of Saints.


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Chairman: John Shimkus (IL)
Vice Chairman: Phil Gingrey (GA)
Ralph Hall (TX)
Ed Whitfield (KY)
Joe Pitts (PA)
Tim Murphy (PA)
Bob Latta (OH)
Gregg Harper (MS)
Bill Cassidy (LA)
David McKinley (WV)
Gus Bilirakis (FL)
Bill Johnson (OH)
Joe Barton (TX)
Fred Upton (MI)
Ranking Member: Paul Tonko (NY)
Frank Pallone, Jr. (NJ)
Gene Green (TX)
Diana DeGette (CO)
Lois Capps (CA)
Jerry McNerney (CA)
John D. Dingell (MI)
Jan Schakowsky (IL)
John Barrow (GA)
Doris O. Matsui (CA)
Henry A. Waxman (CA)
WASHINGTON, DC – House Energy and Commerce Committee leaders responded today to the consent decree filed with the U.S. District Court for the District of Columbia that establishes a deadline of December 19, 2014, for the Environmental Protection Agency to take a final action on the coal ash rule that was proposed in June 2010.
WASHINGTON, DC – The House of Representatives today approved H.R. 2279 by a vote of 225 to 188.
To read DOE's, response, click here.
WASHINGTON, DC – Nuclear Regulatory Commission Chairman Allison Macfarlane appeared before Congress today alongside NRC Commissioners Kristine Svinicki, George Apostolakis, William Magwood, and William Ostendorff at a joint hearing hosted by House Energy and Commerce Subcommittees on Environment and the Economy and Energy and Power.


text:
Tsongkhapa Guru Yoga Commentary
Click to watch full screen
What is World Peace?
Come and dine in a place where distinguished men and women have had some real good food
Being in love really does make life so much more beautiful. And what better declaration of love than the quintessential [...]
Don't keep us to yourself! Spread the love; spread the Dharma.
When you generate a kindness in your heart, everyone will feel it, even the animals that we think are just dumb mute brutes which they are not.
Try this deliciously fresh salad with a bit of crunch to it.
Famous vegetarians include Plato, Socrates, Albert Einstein, Leonardo DaVinci, Paul McCartney, and Natalie Portman.


text:
Identity Thief
Length: 1 hour, 51 minutes
Synopsis: Unlimited funds have allowed Diana to live it up on the outskirts of Miami, where the queen of retail buys whatever strikes her fancy. There's only one glitch: The ID she's using to finance these sprees reads "Sandy Bigelow Patterson" and it belongs to an accounts rep who lives halfway across the U.S. With only one week to hunt down the con artist before his world implodes, the real Sandy Bigelow Patterson heads south to confront the woman with an all-access pass to his life. And as he attempts to bribe, coax and wrangle her the 2,000 miles to Denver, one easy target will discover just how tough it is to get your name back.
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- Man shoots, kills woman on Industrial Road, police say
- How many presidents have played golf at Shadow Creek? Four!
- Wood carries Rebels past Owls in solid bounceback victory


text:
Luca Menin
Headphone brain surgery
Head digital memory
Popping up in empty trunk of dimensions, space
Trapped in vacuum of energy mazes
Gravity squeezed applications
Liquid plasma of information
Vaporized in melted ice
Transforming rivers into skies
Decibel ears snapped by view Pixar eyes
At the touch of an extensions
Rocks are 90 % empty
Hardened by indivisible dimensions
Science grail
The atom quest
Through the existence of sense
Till the Infinity end
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text: Dow's Peace Accord With Loeb Shows Path for DuPont Updated 1 hour ago Can Dow's Deal With Dan Loeb Show Path Ahead for DuPont? Updated 2 hours ago U.S. Will Seek Expanded Ozone Treaty Next Year After Talks Fail Updated 4 hours ago Oil at $75 Won't Shut in Much U.S. Shale, Dow's Liveris Says Syngenta Plans Cuts Affecting 1,800 Jobs to Reduce Costs Dow Chemical Pact With Third Point Avoids Proxy Fight Draghi Says ECB Must Boost Inflation Steve Miller: Dow Chemical Board Moves Prevent Loeb Fight Dow Chemical, Third Point in Board Pact India, China Said to Drop Opposition to Limits on HFCs in Talks Germany Opens Door to Commercial Fracking in Merkel Bill Flooding at Uralkali May Make Potash Corp. Biggest Producer Triton Said to Seek Compo Buyer After Splitting Fertilizer Maker Are Activist Investors Targeting the Wrong Companies? Saudi Arabian Stocks Slip to Lowest Since March as Oil Retreats


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The Top 10 In Action Sports
01This British Council Is Trying To Make Skateboarding A Crime...
02Want To Escape The UK And Surf Every Day? This Is The Place To Go…
03Snowfall In New York Has Been So Deep, People Can't Get Out Of Their Houses
04What Do You Get If You Cross A Zip-Wire With A Roller Coaster?
0523 #FirstWorldProblems People Encounter When Skiing
067 Awkward Moments Every Brit Experiences When Surfing Abroad
07'Has Skiing Made Me Bald?' - What Do You Contemplate When You're On The Chairlift?
08This Squaw Valley Ski Edit Is Not To Be Missed...
09This 22 Year Old Student Took Three Years To Make This Adventure Film. The Result Is Truly Beautiful…
10From Small Photo To Breathtaking Reality: This Ski Trip Is One Of The Best We've Seen...
EyesdownFilms - This is Joel Moore
A Mountain Biking video by eyesdownfilms - 11,505 views
This is Joel Moore, local up and coming riding from the South Wales area Joel Moore is starting to kick up a fuss in the mountain biking scene.
Getting some great results so far this year, 6th at BDS National Champs just behind the legendary Steve Peat, he is a definite to look out for next season.
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text: Tanya great essays, affordable prices and quick delivery! Today Essay Services Offered ♥ India Is the mere thought of that term paper tormenting you? Are you coveting those elusive grades in hopelessness? Do you feel poor writing skills could slow your educational and career growth? Is your assignment a nuisance in the way of something more important that you need to get done? If that sounds like you, we are here to end your worries. Quality papers, before-time deliveries, exciting discounts, two free revisions and perpetual support without shelling out obscene amounts - that's our offer!We're Indian and dedicated, punctual, non-scamming, warm, and qualified (and immodest). Yes, 'cheap prices' is the only stereotype that we don't defy! Get in touch to use our services/know more!


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Purple tritan radish
I've sung the song before. If at first you don't succeed, dust yourself off and try again. We've eaten black radishes, red radishes, pretty radishes, ugly radishes, radishes that… Read More »
Remembrance Day
Last Tuesday was Veterans Day and the older kids were out of school. Sam had a birthday party that chewed up the middle few hours of the day,… Read More »
Carnival squash & sage barley risotto with maple butter
If there's a more Fall-spirited, festive, happy-making dish around, please fill me in. Let's talk about ingredients first, starting with this squash. (I know, I know, three straight… Read More »
Green cabbage
Our experiment with green cabbage serves to illustrate an important point when you're dealing with kids: they're fickle. Mark my words (in fact, look them up on the… Read More »
It was the Mister's birthday last week. 5 golden years, how quickly they've gone. I can still remember the day he was born. I'd snuggled him close to… Read More »
Coconut kabocha soup with Japanese 7-spice
We're talking squash again this week. Two weeks in a row, I hope this isn't a fireable offense. What can I say, I'm passionate about squash. As if… Read More »
Acorn squash
A couple of things went wrong with this experiment. Clearly I haven't learned my lesson about trying new foods when the kids are cranky and hungry. A worse… Read More »
Sticky toffee pudding in 30 easy steps
Ingredients 1/2 to 3/4cups chopped dates 1/2 to 3/4cups apple brandy (or Calvados) 2cups unbleached, all purpose flour 2cups white sugar 2teaspoons baking soda 1teaspoon ground cinnamon 1/2teaspoon… Read More »
Roasted delicata squash with Meyer lemon vinaigrette
If I'm famous for anything in the kitchen, it's my track record for that most heroic of tasks: Thanksgiving dinner. It's a beast, but someone's gotta do it…. Read More »
Baby peppers
Once in a while I choose a horrible time to try new foods. This seemed like a perfect chance – the kids were all sitting in the living… Read More »


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From the Division of General Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH (Dr. Martin); Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS (Dr. Penzien); Center for Pain Studies, Rehabilitation Institute of Chicago, Chicago, IL (Dr. Houle); Department of Biostatistics, West Virginia University, Morgantown, WV (Dr. Andrew); and Pain and Rehabilitation Clinic of Chicago, Chicago, IL (Dr. Lofland).
The Predictive Value of Abbreviated Migraine Diagnostic Criteria
Article first published online: 15 SEP 2005
DOI: 10.1111/j.1526-4610.2005.00234.x
Headache: The Journal of Head and Face Pain
Volume 45, Issue 9, pages 1102–1112, October 2005
Additional Information
How to Cite
Martin, V. T., Penzien, D. B., Houle, T. T., Andrew, M. E. and Lofland, K. R. (2005), The Predictive Value of Abbreviated Migraine Diagnostic Criteria. Headache: The Journal of Head and Face Pain, 45: 1102–1112. doi: 10.1111/j.1526-4610.2005.00234.x
Publication History
- Issue published online: 15 SEP 2005
- Article first published online: 15 SEP 2005
- Accepted for publication December 1, 2004.
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text:
Native Plants
Q. Who is Mr. Smarty Plants?
A: There are those who suspect Wildflower Center volunteers are the culpable and capable culprits. Yet, others think staff members play some, albeit small, role. You can torture us with your plant questions, but we will never reveal the Green Guru's secret identity.
Did you know you can access the Native Plant Information Network with your web-enabled smartphone?
Ask Mr. Smarty Plants is a free service provided by the staff and volunteers at the Lady Bird Johnson Wildflower Center.
Need help with plant identification, visit the plant identification page.
rate this answer
Thursday - February 20, 2014
From: Chicago, IL
Region: Midwest
Topic: Non-Natives, Plant Identification
Title: Plant identification
Answered by: Nan Hampton
QUESTION:I'm not sure of county of origin. It was given to me by someone I no longer have contact with. When I initially received it I thought it was just a small potted vine of some type. I've had it a year and now it is flowering. It has thick vines with large sturdy leaves along the vine pointing upwards towards the tip of the vine. Protruding from the last set of leaves at end of the vine are thin stalks with blooming clusters of tiny four petal orange flowers. Photo available
Our focus and expertise are with plants native to North America and I think that probably your plant is not native. From your description, however, one non-native plant comes to my mind—an orange kalanchoe. There are many species of kalanchoe and most originate in Africa or Asia. One species, Kalanchoe blossfeldiana, originates in Madagascar and can have white, yellow, scarlet, pink, orange or salmon colored flowers. We don't accept photos for identification; but, if this isn't your plant, you can visit our Plant Identification page where you will find links to several plant identification forums that do accept photos of plants for identification.
More Non-Natives Questions
Invasive, non-native Eragrostis cilianensis, stink grass
March 22, 2005 - I am writing a children's book for Darby Creek Publishing about smelly plants and animals. I have read that Eragrostis cilianensis is one of the few bad-smelling grasses. Would the purpose of the o...
view the full question and answer
Eliminating invasive, non-native chameleon plant from Omaha NE
April 11, 2011 - I have been attempting to eradicate the chameleon plant in my gardens for 3 years. I have sprayed Round Up and covered with newspaper then mulch and it is coming back again this year! I am wondering...
view the full question and answer
Foxglove safety from England
April 21, 2013 - Hi, regarding safety of foxgloves grown near edible plants - foxgloves are good companion plants for vegetables, in case of root vegetables they improve their storage life and quality. Foxgloves prote...
view the full question and answer
Recovery of damaged fuchsia plant in hanging basket
July 23, 2007 - I had a beautiful fuchsia plant hanging on my porch. The hanger gave way and the plant fell straight down into another flower bed. The fuchsia seemed ok. I put it back in the pot put up new strong ...
view the full question and answer
Non-native citronella mosquito plant wintering inside in Charlotte NC
October 20, 2011 - Can I bring the citronella mosquito plant in the house over the winter, or should it be planted outside. I live in Charlotte, NC.
view the full question and answer
|Support the Wildflower Center by Donating Online or Becoming a Member today.
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How Should We Feel About a 'Food Porn' Lingerie Set?
That's one way to take #foodporn to actual porn level, we guess.
WATCH: Nigella Lawson's Voice Stars on Modern Family
We too could use some extra help in the kitchen, if Nigella Lawson so wanted to guide us through cooking Thanksgiving dinner. Although we probably don't enjoy it the same way as Phil Dunphy does on Modern Family.
WATCH: Mario Batali Makes a Better Cocktail! And Jimmy Fallon Fails
Has someone been taking bartending lessons, we wonder? Because Mario Batali is really doing well with that muddler, while Jimmy Fallon just sort of gently prods his lemon and apple. Come on Fallon, get into that muddler!
Let's All Collectively Freak Out Over Guy Fieri With Normal Hair
That suit will live on forever, even if the hair does not.
CBS Buys Meatball Shop-Inspired Pilot (Quick, Let's Name Who Should Play Michael Chernow and Daniel Holzman)
Well well, our meatball-slingin' guys are going to be on TV! Well, ish.Read on...
WATCH: Daniel Boulud, Be Our New Year's Eve Date?
Not only do we think Daniel Boulud is just about the nicest guy all-around, he's definitely our dream date for New Year's Eve. Imagine how well we'd eat! Beef wellington with black truffles? Yes please!Read on...
WATCH: Danny Meyer Compares His Restaurant Empire to Cheers (Does That Make Him Sam Mallone?)
It's no secret that Danny Meyer is kind of a big deal in the hospitality world, and now we know why — his whole business model is based on Sam Mallone on Cheers. MIND = BLOWN.Read on...
WATCH: Our Newest Crush, Nick Anderer, Made Us Abbachio Al Forno
We loved seeing Maialino's executive chef, Nick Anderer, talk about traditional Roman dishes, working his way from an art history college program to New York City kitchens, and serving Korean food on Thanksgiving day to his hardworking staff.Read on...
Rich Rosendale Nabs Stint on CBS Saturday Morning Teen Show Alongside Jamie Oliver
Rosendale recently left his post at West Virgina's Greenbrier Resort after representing Team USA in the 2013 Bocuse d'Or, then he did a TEDx talk, and now, he'll be moving on to shiny, television studio pastures, hosting the other half of CBS Saturday morning's newly minted food show time slot.Read on...
Jamie Oliver Is Coming To Your Saturday Morning Cartoons
You know the warm fuzzy feeling that overwhelms your body when you hear mention of ABC-Disney's One Saturday Morning, or NBC's Discovery Kids? CBS is attempting to recreate that nostalgia for a new generation of 13-16 year olds with a fresh three-hour block of "pro-social" Saturday morning programming.Read on...
CBS Dashes Giada And Bobby's Morning Talk Show Dreams
The world is not ready for a syndicated morning talk show hosted by Giada De Laurentiis and Bobby Flay, the New York Post reports.Read on...
With CBS's New Baking Show, Cooking Competitions Continue To Invade Network TV
First we had MasterChef on Fox, where Joe Bastianich, Graham Elliot, and Gordon Ramsay made some poor amateur chefs cry every Monday night. Then came news of ABC's The Taste, the upcoming cooking competition featuring Nigella Lawson and a very harried FCC censor hired solely to edit everything Anthony Bourdain said. Now CBS is getting in on the action too, with their newest unnamed baking competition that's happening. It's totally happening, guys!Read on...
WATCH: Grant Achatz Gives His Younger Self Some Life Advice
"People will tell you you don't have what it takes," he warned. "And right now, you don't…you don't have what it takes right now. But you will."Read on...


text:
HOME > I Wanna Be a Soap Star > I Wanna Be a Soap Star 4 > I Wanna Be a Soap Star 4 News
I Wanna Be a Soap Star 4 News
Cameron Mathison dishes on hectic schedule, 'Dancing' opportunityOctober 15, 2007
Cameron Mathison currently has what he described as a "really hectic" schedule that has him acting on All My Children, hosting I Wanna Be a Soap Star's fourth season, and competing as a Dancing with the Stars fifth-season celebrity participant.
SoapNet orders a fourth season of 'I Wanna Be a Soap Star'March 2, 2007
SoapNet has ordered a fourth season of I Wanna Be a Soap Star -- and for the first time, the winner of the Disney-owned cable network's reality competition series will appear on a non-ABC soap, Daily Variety reported on Friday.
- Kourtney Kardashian reveals when her third child is due and how she'll prepare
- 'The Bachelor' creator Mike Fleiss reportedly arrested for harassing Brooke Burke-Charvet and husband
- 'Hell's Kitchen' chef Aaron Lhamon quits the show before seemingly getting fired by Gordon Ramsay
- 'Survivor: San Juan del Sur -- Blood vs. Water' eliminates Jeremy Collins
- Diem Brown remembered by on-and-off love Chris 'CT' Tamburello
- 'Love & Hip Hop' star Erica Mena and fiance Bow Wow set wedding date
- Dean McDermott: My marriage with Tori Spelling is better and stronger than ever
- Kathy Griffin to reportedly replace the late Joan Rivers on 'Fashion Police'
- Janice Dickinson accuses Bill Cosby of raping her about 30 years ago


text:
Select a region below to explore Resorts & Lodges in that destination.
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- Mammoth Lakes (3)
- North Coast California (2)
- Orange County (12)
- Palm Springs (19)
- San Diego (12)
- San Francisco Bay (14)
- Shasta Cascade (1)
Historic Charm on Tahoe's Shore
On the picturesque west shore of Lake Tahoe stands Tahoe Tavern Properties, a historic property...
Luxury - Resorts and Lodges in California
California is a state that offers luxury in many forms. Catch a tan on your beach house shores in Los Angeles or the Central Coast, breathe in the fresh mountain air at your Sierra Nevada chalet, sip a vintage wine in a Napa Valley chalet, or dip your toes in Lake Tahoe outside a sprawling resort. No matter what the terrain, you'll find exceptional accommodations and amenities in this West Coast oasis. Elegance is expected at luxury resorts like Solage Calistoga, Hotel Healdsburg, and Glorietta Bay Inn.
Surround yourself with lush gardens and the cool, salty ocean breeze of California's central coast at Sea Otter Inn. Luxury suites include private Whirlpools, fireplaces and some even have private garden patios overlooking a colorful spring. Take a wine tasting tour to awaken all of your senses.
Coastal Vacation Rentals features a wide range of Pismo Beach, California accommodations near the beautiful white-sand beaches. These units are equipped with modern touches to ensure you have a comfortable and convenient vacation. Whip up home-cooked meals in your private kitchen, enjoy the views from your balcony, and relax after a long day in the...
The Ritz-Carlton, Laguna Niguel premiered as the first luxury beach resort along coastal Orange County. Today, the Dana Point resort boasts a newly re-imagined vibe, services and spaces, yet still occupies its perch atop 150 foot bluff featuring cascading views of the Pacific Ocean. With two swimming pools, two whirlpools, two tennis courts, a...
If 535 fireplaces, 41 pools, 53 hot tubs, 23 tennis courts, 7 restaurants and 5 golf courses doesn't scream luxury, then nothing does. La Quinta Resort and Club invites you to challenge yourself on the links, indulge in your choice of fine restaurants, relax via the spa or hot tub, or whatever you want. Your luxurious desert escape awaits at La...
Redwood Coast Vacation Rentals features a wide selection of accommodations along the California Coast that offer everything you're looking for in a comfortable and convenient vacation. Equipped with full kitchens, spacious living rooms with cable television and DVD player, wireless internet, gas grills and more, you will feel right at home. Many...
Discover a truly luxurious Sonoma destination at the Sonoma Coast Villa & Spa Resort. Here, beautiful, terraced gardens lead to rooms boasting private patios, wood burning fireplaces and fresh cut flowers. The restaurant specializes in organic, Wine Country cuisine, and daily complimentary wine tastings bring Sonoma to your taste buds.
Check out the Splendido Jacuzzi Suites for the ultimate luxury spa experience at Roman Spa Hot Springs Resort. With etched stone, mosaic tile and marble featured throughout, the suite seems more like a work of art than a resort accommodation. A romantic fireplace and sound system will help you set your perfect mood. Slip into your chamois robe...
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You will never have to leave the comfort of the hotel for entertainment when you stay at the Manchester Grand Hyatt San Diego. Seven onsite restaurants, an onsite spa and exceptional outdoor pool facilities are just a few of the amenities you will enjoy during your stay. Plus your room choices are amazing as well! The Premium View King, for...
From the stunning meditation garden featuring fire pits and lush tropical plants, to the exquisite furnishings throughout the hotel, luxury surrounds you at every turn during your stay at Tradewinds Carmel! Some guest rooms feature amazing amenities like a fireplace, private balcony and spa-jetted tubs. And, if you are having a hard time filling...
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Short Cuts
Feastday: May 30
Birth: 1844
Death: 1895
Beatified By: 28 September 1993 by Pope John Paul II
Canonized By: 25 November 2001, Saint Peter's Square by Pope John Paul II
Not much information is known about Elizabeth, but she has the distinction of being one of the first to know about Mary's great blessing as the Mother of God. Zachary was a priest in ... continue reading | shop
St. Thomas Aquinas, priest and doctor of the Church, patron of all universities and of students. His feast day is January 28th. He was born toward the end of the year 1226. He was the son ... continue reading | shop
Francesco, named in honor of St. Francis of Assisi, was born to Giuseppa and Grazio Forgione, peasant farmers, in the small Italian village of Pietrelcina on May 25, 1887. From his ... continue reading
Born on January 13, 1891 in Guadalupe, Mexico, Miguel Agustin Pro Juarez was the eldest son of Miguel Pro and Josefa Juarez. Miguelito, as his doting family called him, was, from an early age, ... continue readingMore Saint of the Day
Margaret was an English princess. She and her mother sailed to Scotland to escape from the king who had conquered their land. King Malcolm of Scotland welcomed them and fell in love with the beautiful princess. Margaret and Malcolm were married before too long. As ... continue readingMore Female Saints
St. Michael the Archangel - Feast day - September 29th The name Michael signifies "Who is like to God?" and was the warcry of the good angels in the battle fought in heaven against satan and his followers. Holy Scripture describes St. Michael as "one of the chief ... continue reading
The name Gabriel means "man of God," or "God has shown himself mighty." It appears first in the prophesies of Daniel in the Old Testament. The angel announced to Daniel the prophecy of the seventy weeks. His name also occurs in the apocryphal book of Henoch. He was the ... continue reading
Dymphna was fourteen when her mother died. Damon is said to have been afflicted with a mental illness, brought on by his grief. He sent messengers throughout his town and other lands to find some ... continue reading
St. Zita was born into a poor but holy Christian family. Her older sister became a Cistercian nun and her uncle Graziano was a hermit whom the local people regarded as a saint. Zita herself always ... continue reading
By Deacon F.K. Bartels
St. Teresa's whole life is one of simple beauty and fervent purpose; it is a life contained in Christ. She shows us how to live the same way through Prayer.On reading from St. Teresa, a deep feeling of her love for His Majesty envelops us; we begin, in a very real, ... continue readingMore Christian Saints & Heroes


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For 91 Days on Boise's Own KBOI 2
We woke up at 3:30am in order to make the drive from Cascade to Boise, to appear live on AM Extra on KBOI 2. Check out the video… you might be able to tell we're not accustomed to being on camera, but it went pretty well. Especially considering that at this early hour, we're normally fast asleep.
Thanks so much to the news crew: J Bates, Stephanie Smith and Adam Behrman (who hails from my corner of the world: northwest Ohio!)
KBOI 2's AM Extra – Website
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August 31, 2012 at 1:49 am


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Winnipeg Free Press - PRINT EDITION
K.C. has Bills to take care of
Amazing Chiefs continue pursuit of perfection in Buffalo
ORCHARD PARK, N.Y. -- Perfect record. Worst-to-first turnaround. Trap game.
Chiefs coach Andy Reid has no difficulty guarding against getting swept up by the headlines and hype surrounding Kansas City's perfect start. He chooses to tune it all out.
"I'm pretty simple, guys," Reid said, declining to indulge questions on why the Chiefs (8-0) are winning in his first year on the job and following a league-worst 2-14 finish last season. "All those are good stories. I just haven't thought about any of that. I mean, your mind never goes there. You just kind of keep pushing ahead."
Reid is focused solely on today, when the Chiefs travel to play the Bills (3-5), a team that similarly went through an off-season transition and is also off to a better-than-expected start under first-year coach Doug Marrone.
This is no time for the Chiefs to peek ahead to their upcoming bye week, followed by an AFC West showdown against the Peyton Manning-led Broncos. And it's immaterial to Kansas City's stingy and sack-happy defenders that Buffalo could be down to its fourth-string quarterback -- undrafted rookie Jeff Tuel or newly signed free agent Matt Flynn -- with interim starter Thad Lewis nursing bruised ribs.
"We're not satisfied," linebacker Derrick Johnson said. "Buffalo is a good team. We're not going to overlook them at all. That's not even a conversation."
The Chiefs have the Bills' attention for various reasons, including providing players a sense of hope in believing a turnaround might not be far off for Buffalo.
"That franchise is motivation for the Bills," receiver Stevie Johnson said. "We can do the same thing."
Both have similar pasts. Buffalo hasn't made the playoffs in a league-high 13 seasons, and is on its sixth coach since 2000.
The Chiefs are on their sixth coach, and made the post-season only three times over the same span.
The Bills haven't been pushovers this season. They're 2-2 at home, with both losses decided by a combined margin of five points.
"We don't think we're far from where they are," centre Eric Wood said. "We're sitting at 3-5, but the film shows a much better team than that."
Here are four things to look out for as the two non-division rivals meet for the sixth straight season:
SACK ATTACK: It's no coincidence the Chiefs have a league-leading 36 sacks, and the Bills are second with 27. Both defences feature new co-ordinators who developed their attacking styles under New York Jets coach Rex Ryan.
Kansas City's Bob Sutton spent the past four seasons in New York as a senior defensive assistant and linebackers coach, while Buffalo's Mike Pettine was the Jets' defensive co-ordinator.
They've both introduced Ryan's up-tempo and aggressive schemes to their defences.
AVOIDING A TRAP: With a chance to match their best start in franchise history, the Chiefs have several other reasons to avoid looking past the Bills in opening the second half of their schedule.
Coming off three straight home games, the Chiefs close with five of eight on the road. They also have five games against division rivals, including two each against Denver and San Diego.
The schedule's lining up to be tougher, too. Kansas City's first eight opponents currently have a combined record of 21-40. Their final eight: 35-24.
QB SHUFFLE: Bills rookie starter EJ Manuel (sprained right knee) isn't yet ready. Kevin Kolb (concussion) is on season-ending injured reserve. And Lewis' status is uncertain.
That leaves Marrone preparing to choose between Tuel, who struggled in replacing Manuel in a 37-24 loss at Cleveland on Oct. 3, and Flynn, signed a week later after being cut by Oakland.
Flynn might be in his sixth NFL season, but Tuel has the early edge because he's more familiar with the offence.
"I feel better about Jeff right now because I know Jeff," Marrone said. "That's not to say Matt's not good enough. I just haven't seen enough of Matt."
LIMPING OFFENCE: Quarterback isn't Buffalo's only concern in facing a Kansas City defence that's not allowed more than 17 points this season.
The Bills' top two running backs, C.J. Spiller (sprained left ankle) and Fred Jackson (sprained left knee), are nursing injuries. Jackson expects to play, and Spiller is likely to return after missing one game. Johnson, their leading receiver, is bothered by an assortment of injuries, including a sore hip.
-- The Associated Press
Republished from the Winnipeg Free Press print edition November 3, 2013 B12
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Black Duck Software is the leading supplier of open source software governance and compliance management solutions. We are seeking an energetic individual to join our Business Development team to generate qualified prospects for sales to close. Success in the BDR role requires a10/13/2014 Burlington, MA Save This Job
Location: Boston, MAType: Full TimeMin. Experience: Entry Level The GuideSpark Revenue Development Representative role is on the front lines of revenue generation. The GuideSpark Revenue Development Representative role is a high activity, high volume role focused on maximizing10/30/2014 Boston, MA Save This Job
Location: Menlo Park, CAType: Full TimeMin. Experience: Entry Level The GuideSpark Revenue Development Representative role is on the front lines of revenue generation. The GuideSpark Revenue Development Representative role is a high activity, high volume role focused on10/30/2014 Menlo Park, CA Save This Job
ON24 is the global leader in webinar-based marketing solutions that drive demand generation and customer engagement. Its patented cloud-based platform features an interactive and immersive user interface and industry-leading webinar analytics for events, campaigns and11/25/2014 San Francisco, CA Save This Job
If you are ambitious and looking to jumpstart your career in sales, this is the opportunity for you! The Account Development Representative (ADR) will be a front line key business developer for Mirantis OpenStack Express (MOX). The ADR will generate new business opportunities11/17/2014 Mountain View, CA Save This Job
More information about this job: Overview: Aerohive Networks?the pioneer in controller-less Wi-Fi?reduces the cost and complexity of today's networks with cloud-enabled Wi-Fi and routing solutions for medium and large enterprise headquarters, branch offices and teleworkers.11/3/2014 Atlanta, GA Save This Job
ON24 is the global leader in webinar-based marketing solutions that drive demand generation and customer engagement. Its patented cloud-based platform features an interactive and immersive user interface and industry-leading webinar analytics for events, campaigns and10/26/2014 Charlotte, NC Save This Job
Zuora is the leader in subscription billing software and we are growing like crazy. We have an epic opportunity for you to join our fast growing team where you can have an impact on our revenue growth as we sprint for an IPO. We offer competitive salaries, great benefits, and a10/22/2014 Foster City, CA Save This Job
If you are seeking to develop your career in sales and the opportunity to gain invaluable skills in business, you are in the right place. We are looking for talented individuals to start a career in technology sales with a rapidly growing software company. Emgage is a Microsoft11/24/2014 Santa Monica, CA Save This Job
The Account Development Representative at Delphix will have provide a high-level of impact drive lead generation, navigate enterprise organizations, and identify and create new qualified sales opportunities. This high impact role will help organizations use Delphix? Data11/25/2014 Menlo Park, CA Save This Job
Ping Identity is continually hiring smart, energetic and passionate people to join our Customer Care team on a contract basis. The Customer Care Representative (CCR) position is for individuals who are ready to embark and learn the fundamentals of sales qualification. As an11/18/2014 Denver, CO Save This Job
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Department: Telesales Location: Palo Alto, CA Reports to: Jeremy Collins Summary: The primary goal of the Sales Development Representative (SDR) is to increase the qualified pipeline of new opportunities, as well as, increase sales volume of the Ooma Office product and services.11/12/2014 Palo Alto, CA Save This Job
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Department: Sales Location: 30066, GA Employment Type: Full Time SUMMARY: The Business Development Representative is responsible for prospecting, qualifying and generating new sales leads to support the National Sales Executives. The ideal candidate must be a highly10/14/2014 Alpharetta, GA Save This Job


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Scotland manager Gordon Strachan felt little could be gleaned from the 1-0 win over UEFA Euro 2016 qualifying rivals Poland on Wednesday.
Celtic's Scott Brown was the Scotland goal hero for the second game running, as he followed up his match winner against Norway in November with another decisive strike to settle the friendly in Warsaw.
The game was arranged well in advance of the UEFA 2016 qualifying draw that pitted the two nations together in Group D, with Strachan's men due to return to Poland in October.
And while Strachan lauded his captain Brown, he believes it would be foolish to read anything into the result.
"It was not a great game and you can't expect anything other than that at this time of year," said Strachan.
"Scott Brown was the man of the match and the goal sealed it.
"But it meant absolutely nothing as these two sides will not be the same for the Euro 2016 campaign, but it gives us confidence and builds nicely to our next friendly."
Brown retained the armband, despite the return of Manchester United's Darren Fletcher, who made his first appearance for his country since October 2012 as a second-half substitute after being sidelined through illness.
But it was a captain's performance from Brown, who was dogged in midfield, although he was perhaps lucky to stay on the field after a first-half altercation with Slawomir Peszko, after which both players were booked.
When Brown's winner arrived in the 77th minute, it was a thunderous effort passed Arsenal goalkeeper Wojciech Szczesny.
"It was with my left-foot as well," said Brown.
"One of those that could end up in row Z, but fortunately it went in.
"We are doing what the manager is telling us and we are looking like a team out there.
"It is good to get a game against our group opponents and show what we can do against them."
|G. Fay
|F. Brown
|R. Corsie
|J. Beattie
|J. Love
|L. Ross
|M. Sneddon
|K. Little
|J. Ross
|H. Lauder
|L. Evans
|Coach: A. Signeul
|A. Szymanska
|N. Krzysik
|A. Sikora
|W. Aszkiełowicz
|M. Mika
|N. Chudzik
|S. Gonzalez
|E. Nicinski
|P. Balcerzak
|N. Pakulska
|P. Wisniewska
|Coach: W. Basiuk
for J. Love 60'
for H. Lauder 76'
for L. Ross 90+2'
for S. Gonzalez 71'
for N. Chudzik 89'
for E. Nicinski 90+3'
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