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|By David Stanley
Article Rating:
|July 9, 2014 09:45 AM EDT
In the pharmaceutical industry, the drug development clock is ticking at the rate of warp-speed. As a result, companies are constantly looking for solutions to help them accelerate time to market - and many are realizing that implementing a cloud-based information management system can bring much needed clarity, organization and efficiency to the complex documentation processes and protocols required to bring a drug to market.
One such company is Singapore-based Lypanosys, an early-stage pharmaceutical company developing a clinically differentiated drug for the dermatology market. Blaine Ah Yuk-Winters, the project manager of the geographically dispersed pharmaceutical startup, describes Lypanosys as a virtual company in the sense that its manufacturing, preclinical, and clinical development activities are spread across the US, Asia, and Australia.
Addressing the Documentation Challenges within the Pharmaceutical Industry
According to a survey by the consulting group Ovum, pharmaceutical companies are ahead of other industries when it comes to adopting enterprise applications, such as enterprise resource planning (ERP) and customer relationship management (CRM) solutions, but lag behind in the adoption of business intelligence solutions such as regulatory tracking/management systems that can harness data more productively. Furthermore, an FDA CTD/eCTD (Electronic Common Technical Document) quality reviewer survey noted that only about half of sponsors do a good or excellent job in organizing documents according to CTD best practices.
While this may help explain why some pharmaceutical firms have been slow to implement hosted document and data management systems, Lypanosys is the sort of international venture that cloud computing was invented for.
"We found a solution that enables us to get all of our files into a cloud-based enterprise content management system, which we can access wherever we are," said Ah Yuk-Winters.
The cloud has worked well Lypanosys so far. All of the company's documents reside on a hosted server and can be easily shared among project participants regardless of location. As a result, Lypanosys can operate virtually - or "office-lessly."
The Implications and Repercussions of Poor Information Management
Poor information management can create a bottleneck for companies on multiple levels, as well as add unnecessary cost burdens. For example, take the cost of storage: failing to manage data appropriately results in the retention of redundant information and records, which occupies storage space within a system. There's also the time-cost associated with chasing down information needed to meet regulatory requirements or to make an important business decision.
According to Ah Yuk-Winters, these were important considerations during Lypanosys' evaluation of various cloud-based information management systems. Unfortunately, many cloud offerings, such as the first one Lypanosys tried, are frustratingly slow.
"With the other system we tried, it was not so much the time it took uploading and downloading documents, it was the time it took maneuvering inside the interface. It was quite sluggish. When you clicked on a folder, it would often take 15 seconds to open."
The initial cloud system Lypanosys deployed structured files in multiple levels of traditional folders and subfolders. To get to a file they wanted, users could have to wait several minutes for the interface to open the final folder location - not including the time to download the document.
"We just couldn't employ the system for daily use," added Ah Yuk-Winters.
However, the system Lypanosys ultimately selected and deployed, M-Files, delivered the required performance at both the users' desktop interface as well as its remotely hosted servers.
The solution integrates its document and workflow controls in Windows Explorer and Microsoft Office as well as any other Windows application, so the way information is saved and retrieved is already familiar to most PC users. And because its search capability is based on efficient indexed metadata and "full text" content - rather than traditional folder structures - users can sort through content and find the files or other important information they need in seconds. Even with larger files, such as submission documents for the FDA, M-Files' unique caching and server synchronization capabilities enable silent and quick uploading in the background, so users can move on to other tasks. The result is performance that feels like the system is running on users' local PCs, yet information actually resides in the cloud.
"One of our directors needed a report to provide to a potential investor. He was actually in an airport in transit in Asia and was able to quickly locate the file and send it off. He was impressed with how easily that went. We are very happy with the system's responsiveness," continued Ah Yuk-Winters.
On the server side, the information management system runs on the Windows Azure cloud platform, which operates from Microsoft data centers around the globe. With the Windows Azure platform, the system delivers flexibility and reliability to users, whether they're in Auckland or Ankara.
"For accessing content, it's really quite fast," says Ah Yuk-Winters. "The searching and retrieving features are great. The way you can sort documents into different types and groups with metadata is fantastic."
Keeping Order in the Cloud
A significant advantage of cloud-based systems lies in their reliability and scalability. Raw storage without other information management capabilities, such as solutions offered by popular file sharing services like Dropbox and Box, can quickly turn into a disorderly mess of folders, just as it does with on-site "on-premise" servers when traditional Windows folder structures are used for categorizing and storing documents.
An effective hosted information management solution can manage hundreds of thousands -- and even millions - of documents. Managed documents and other types of information can range from lab notebook entries, study data, biomarkers, formulation studies, and statistical analyses to GLP (Good Laboratory Practice) compliance documents, patent analyses, market research, patent filings, product commercial path scenarios, IND (Investigational New Drug) submission strategies, toxicology reports, templates, and the list goes on and on...
A cloud-based document and information management solution should also provide collaboration features, such as the ability to easily share files with internal employees or external partners and check-in/check-out to manage document creation and editing in a team environment, as well as workflow features for automating business processes, the ability to quickly scan paper documents into the system with optical character recognition (OCR) to create searchable PDF files, a user-friendly interface, tracking/audit trail features, support for compliance with regulations such as FDA 21 CFR Part 11, EU GMP Annex 11, etc., version management for tracking document and information history, reporting features and compatibility with training software controls. The system should also be compatible with existing legacy enterprise systems, such as ERP and CRM solutions.
Lypanosys found a solution that addressed these critical needs, and as a result, was able to bring order and efficiency to their chaotic document and information universe by organizing and indexing every item in the centralized cloud repository. The solution also featured flexible yet strict access permissions functionality and a complete compulsory version history for everything.
"M-Files saved us a lot of time over what we had going on with just a folder structure," says Ah Yuk-Winters. "Before, when we had to submit a filing to the FDA it was difficult to find the relevant documentation we needed. There were duplicates everywhere. Trying to find a document and not knowing which version was the latest was a nightmare. Automatic versioning is essential when you have multiple people in different locations revising the same work."
Flexible permission controls also enable Lypanosys to authorize third-party consultants and advisors to sign in to the company's system to access selected materials and then save their own versions of documents, without the risk of upsetting organizational processes.
"The ability to share files with consultants overseas has proved very handy. They can pull files whenever they want at any time they want."
Realizing the Benefits of Hosted Information Management
An information management system can help pharmaceutical companies and related organizations become more responsive by making it easy and fast to locate the latest version of any document or information object, dramatically reducing the time associated with document requests, audits, and submissions. It can also help enforce security, protect and archive institutional knowledge, and streamline regulatory compliance procedures. Personnel resources are also conserved by reducing the need to handle and store paper.
With an effective information management system in place, pharmaceutical companies can literally shave years off the drug development clock by getting all company documentation, information and processes under control, while also providing insight and business intelligence into how information is being used and where company processes can be improved. This proactive approach towards information management, process automation and consistent tracking leads to higher quality reviews and efficient, successful audits, greatly reducing the risk of noncompliance while providing 100% traceability of all documents, records and cases across the organization.
Couldn't all this be done with a traditional on-premise solution too? Yes, it could, but the cloud changes the equation by eliminating the need to purchase and configure servers, as well as reducing the IT resources needed to maintain them. Further it reduces upfront costs, allowing organizations to pay for cloud solutions with smaller, more manageable monthly payments.
If your organization is experiencing challenges with managing and finding information, or could benefit from improving the way submissions and audits are handled, a modern information management system can help - and the cloud provides a compelling alternative that eliminates barriers that may have prevented implementing such a system in the past.
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Video: Python pizza on the menu in Florida Everglades restaurant, and guess what? It 'tastes like chicken'
Would you eat a sssssssssssssssssslice?
Saturday 01 February 2014
A new delicacy has slithered onto plates at a Florida restaurant – python pizza.
The swamp special at Evan's Neighborhood Pizza also includes alligator sausage, frogs' legs and pork.
The restaurant, in Fort Myers, has been serving snake for two years on the special "Everglades Pizza".
Evan and Avis Daniell, the owners, came up with the unusual topping amid warnings that Burmese pythons were invading the national park, threatening local biodiversity.
"People talk about it all the time and whether it's negative or positive, it really doesn't matter because the fact is: we can make it and it's delicious," said Mr Daniell, 52.
He insisted the python pizza was tasty, with the snake meat tasting like chicken "but a bit more chewy".
It has become a bestseller at the restaurant. Mrs Daniell said customers were happy to pay $45 to try it "like a dare".
It is currently illegal to hunt and kill pythons in Florida, where many are kept as pets, so the meat is imported.
Thousands of Burmese pythons have been invading the national park after apparently being released by owners and multiplying.
Sitting at the top of the food chain, they have no natural predators in Florida and can grow up to six metres long.
Additional reporting by AFP
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Follow along with step-by-step beading projects and share your designs with beaders around the world—it's quick & easy!
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About this design:
this is by far one of my favorite pieces that I have made. I found the carved rectangular bead first and focused the necklace around it. my favorite color scheme.
Components:mookite, assorted gemstones, czech pressed glass, silver components
Read the comments (or add your own)
Oooooohhhhh … aaaaahhhhh … (sigh) … this is utterly gorgeous Jamie Marie. I adore it … the colors … the design … everything!
thank you!
I agree! This is gorgeous! Love the design,etc. A winner, Jamie!
Me three! SOOOO gorgeous!
Make it four!!
Excellent design!!
VERY NICE! lOVE THE MOOKITE!
Love it
Still LOVE it!
thank you!!!
This came together very nicely. Good eye for color & balance!
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Airbnb is revolutionizing the way the world travels. Tagged by Time Magazine as the "eBay of Space", Airbnb is a profitable, fast-growing, online marketplace giving everyday people the ability to monetize their most valuable asset: an extra bedroom, vacation rental, airbed,11/5/2014 San Francisco, CA Save This Job
Department: Regulatory Affairs Job Title: Head of Reg. Affairs & QA Job Location: San Diego, CA Description: The Head of Regulatory Affairs and Quality Assurance will be responsible for leading and directing all regulatory and quality activities for Ambit Biosciences. They10/18/2014 San Diego, CA Save This Job
What it?s about As our engineering leader, you will play a critical role in SecondMarket?s continued success by working directly with Engineering, Product, and Operations teams to define, build, and deliver world-class quality and highly scalable products while growing a10/4/2014 New York, NY Save This Job
Job Description About Us: At CloudFlare, we have our eyes set on an ambitious goal -- to build a better web. We believe that with our talented team, smart technology and engaged users we can solve some of the biggest problems on the web. We already serve more web traffic than10/13/2014 San Francisco, CA Save This Job
ARGOS IS GROWING! After having met several important milestones including exciting clinical data, we are poised for new strategic objectives which will require significant new resources. Those new resources include a well-qualified person to head our Manufacturing10/12/2014 Durham, NC Save This Job
Job Code: 14-928 Location: Rockville, MD Applicants must meet the following requirements: An undergraduate degree in business, computer science, engineering, or a related field is required; advanced degree preferred. A minimum of 15 years of broad-based information11/3/2014 Rockville, MD Save This Job
Quantcast is an organization that lives and breathes data. Data is used in every aspect of our business, driving everything from our audience measurement service, to our real time bidding, and even corporate operations. We interact with data at scale, regularly processing 30+ PB10/21/2014 San Francisco, CA Save This Job
Job Description About Us: At CloudFlare, we have our eyes set on an ambitious goal -- to build a better web. We believe that with our talented team, smart technology and engaged users we can solve some of the biggest problems on the web. We already serve more web traffic than11/12/2014 San Francisco, CA Save This Job
The Director of Marketing will report to the CEO and be responsible for the full range of marketing activities for Netuitive. This person will manage his/her budget and future staff to develop Netuitive thought and product leadership within the IT Operations Analytics space as10/4/2014 Reston, VA Save This Job
Fulcrum, a leading provider of marketing analytics and technology solutions, is seeking an operations manager. This is a great opportunity for an experienced operations professional to work with a range of technologies in a high-paced environment. Description of Role: We are a9/30/2014 New York, NY Save This Job
Type: Full Time Min. Experience: Mid Level At Dataminr, we are seeking a Senior Data Analyst to join our Data Analysis Team. The responsibilities for this position are comprehensive, including overseeing our multilingual analysis team, conducting in-depth analysis of large data10/4/2014 New York, NY Save This Job
A Technical Project Manager at Verimatrix is a highly visible, customer-facing team member responsible for managing complex, multi-phase high-profile, and mission-critical customer projects for our customers, partners and resellers. The Technical Project Manager represents10/22/2014 San Diego, CA Save This Job
The Recruiting Manager will serve as the point of contact for the Business Operations function at Quantcast, building out one of our most rapidly growing areas of our company. The Business Operations group is responsible for ensuring the successful delivery and optimization of10/21/2014 San Francisco, CA Save This Job
About us: Revionics delivers the industry?s most powerful End-to-End Merchandise Optimization solution, enabling retailers of all sizes to execute a fact-based Omni-channel merchandising strategy utilizing the most comprehensive set of shopper demand signals to enhance financial10/12/2014 Austin, TX Save This Job
About CRITEO Criteo is a global leader in digital performance advertising, working with over 5,000 companies around the world. Criteo has over 800 employees in offices across the U.S., Europe and Asia serving more than 40 countries. Why work for us? Our greatest asset is our9/14/2014 New York, NY Save This Job
In the role of Solution Architect (deployment / support engineer) you will work directly with customers to define requirements related to their ALM task repositories and information systems and design an ALM integration solution using Tasktop Sync.Flexible Location: United Kingdom
Reports To:Head of Product Status:Permanent Overview We are seeking an experienced, technically savvy and highly organized Product Manager who will lead a cross-functional team through idea generation and discovery, product definition, development and product launch. The Product9/22/2014 San Francisco, CA Save This Job
Accelerate your career as you develop one of our fastest growing industry segments ? our emerging Oil & Gas Business Unit. Established in 1993, EPAM Systems (NYSE:EPAM) is a leading global provider of Software Engineering, Consulting, QA/Testing and Support/Maintenance services9/28/2014 Newtown, PA Save This Job
Plastiq (pronounced "Plastic") is a fast-growing tech company changing the landscape of payments, empowering you to use your cards everywhere cards aren?t accepted. Starting with a vision to drive new payment choice for tuition, Plastiq has evolved into a service enabling11/24/2014 San Francisco, CA Save This Job
About Netuitive Netuitive replaces human guesswork with behavior learning technology to automate performance analysis. The company?s software solution is offered as a service (SaaS) and on-premise, and allows users to visualize, isolate, and proactively address IT performance11/3/2014 Reston, VA Save This Job


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Mod reader Cgeylikmanfps wrote in with the URL for a website that has a previously unmentioned BIONICLE� game available to play. It was part of a contest, but the deadline has passed so while you may be able to register a new high score, you won't get the associated prize package. If you want to check it out, you can find it


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D.C denies George Washington Hospital's bid to relaunch kidney transplant business
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- Ben Fischer
- Staff Reporter- Washington Business Journal
George Washington University Hospital's plans to reactivate its dormant organ transplant program have been stymied by a top D.C. regulator, keeping competitor MedStar Health's near monopoly in the city alive.
The hospital, which had shut down its small transplant program in the late '90s, learned May 31 it would not receive a required "certificate of need" to begin kidney and pancreas transplants, a blow to one of CEO Barry Wolfman's major strategic initiatives since arriving in April 2012.
"We are disappointed and will be appealing the decision," said hospital spokesman Steven Taubenkibel.
In its regulatory filings, George Washington highlighted statistics showing that fewer transplants have been performed citywide since Howard University Hospital closed its program in 2010. The declining transplants, a 12 percent drop for kidneys and a 42 percent drop for pancreas, stands at odds with growing incidents of end-stage renal disease, officials said.
Also, George Washington had argued, wait lists are growing at the facilities that still perform transplants. In 2011, MedStar's two hospitals, Washington Hospital Center and Georgetown University Hospital, did 79 percent of all kidney transplants (and 100 percent if you don't count pediatric transplants and patients at the Walter Reed military hospital).
MedStar opposed George Washington's request, essentially saying a monopoly is in the public interest because medical outcomes are best — and costs are most efficiently managed — in high-volume operations.
In his decision, Amha Selassie, director of the State Health Planning and Development Agency, said George Washington could not prove that there is insufficient hospital capacity.
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Tesco bucks recession as overseas sales soar
But growth at UK stores is likely to be overtaken by that of its smaller rivals
Wednesday 17 June 2009
The retail giant Tesco trumpeted the strength of its international business yesterday and robust UK first-quarter figures, but the grocer's domestic sales continue to lag substantially behind its big three rivals.
The UK's biggest supermarket chain posted a 12.6 per cent rise in group sales, excluding petrol, as international sales rose 20.1 per cent at actual exchange rates for the 13 weeks to 30 May.
Lucy Neville-Rolfe, Tesco's corporate and legal affairs director, said: "Obviously, it has been a very difficult period in the economies that we operate and we have had very good growth, which demonstrates how useful our broad strategy is. Asia went into recession the latest and China is already beginning to show signs of recovery."
Tesco – which operates in 14 countries, including the US, Poland and the Czech Republic – said sales grew by 43.8 per cent in Asia, helped by favourable exchange rates with the weak pound and an "excellent performance" in South Korea.
In the UK, Tesco posted like-for-like sales, excluding petrol and VAT, up by 4.3 per cent, marginally down on the 4.4 per cent delivered in the first six weeks of its financial year.
While analysts at Shore Capital said this was Tesco's strongest UK underlying sales since the first quarter of 2007, its rival Sainsbury's is expected to post first-quarter underlying sales of 6.4 per cent today and Morrisons delivered an 8.2 per cent uplift, excluding fuel and VAT, for the 13 weeks to 3 May. For the three months ended March, Asda posted first-quarter like-for-like sales of 8.4 per cent, excluding petrol, the timing of Easter and the effect of a leap day in 2008.
Andrew Kasoulis, at Credit Suisse, said: "Although Tesco still lags its main peers in terms of headline like-for-like sales, Q1 sales are further evidence that the absolute performance remains very robust." Credit Suisse expects a "gradual convergence" in underlying sales among the big four grocers over the rest of the year. Last September, Tesco started introducing hundreds of discount brand products to fight back against the discounters Aldi and Lidl.
Tesco also relaunched its ClubCard with £150m on 11 May in a move that lets customers exchange vouchers for double value rewards tokens in store and online on a wide variety of products. Ms Neville-Rolfe said it had already hit its target of more than one million customers doubling up their vouchers. "ClubCard has [particularly] helped with clothing and wine," she said.
Overall, Tesco said that its UK non-food business had "resumed modest like-for-like growth", citing an improved performance on electricals, homewares, horticulture and toys. However, some City analysts said the return to form of its non-food implied its underlying food sales had slowed. Jonathan Pritchard, at Oriel Securities, said: "We continue to believe that Tesco's UK marketing lacks verve at the moment and have never been convinced by the discounter ranges."
Total UK sales, excluding petrol, jumped 9.3 per cent, boosted by revenues from Tesco Personal Finance unit.
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Ronin: Spirit of the Sword is a Flash game which can be found on Newgrounds. Is a first-person adventure game, divided in three parts, involving dungeon exploring and sword fighting. And also some seriously NSFW stuff.You play as a blue-haired ronin, a swordmaster who's trying to recover an ancient, powerful scroll from the evil ninja master Red Fox. Captured by the ninja's minion, he's imprisoned in her mansion, but saved by a girl named Rei, who wants to end Red Fox's threat by any necessary mean. Together they join their forces to battle Red Fox' followers and stop her.
This game contains examples of:


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Toronto concert picks for Thursday: Black Rebel Motorcycle Club, Foxygen, HIM
Toronto Star's best bets for live music on May 9
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Black Rebel Motorcycle Club
They've moved into middle age on a sombre note, opening shows in honour of Michael Been, father of frontman Robert and leader of '80s outfit The Call who died of a heart attack three years ago while on the road as BRMC's sound man. This tour, off the recent Specter at the Feast release, is their first large-scale work since, adding a touch of poignancy to their ringing, classic rock sound. Kool Haus, doors 7 p.m.
Sometimes, striking while the iron is hot can put pressure on a young band. This California pair with a goofy, tuneful take on 60s rock were in just two months ago co-headlining a show that went well, but all has not been peace and since. Their SXSW grind was curtailed due to exhaustion and they subsequently cancelled a Euro tour for "creative health" reasons. Now they're right back at it, and let's hope the mojo is there, because that debut record marks them as reshapers of some ability and wit. With Miami's noisy Crumbs. Wrongbar, 8 p.m.
Veteran metal-pop act from Helsinki are Euro faves who have been pouring out hard, but melodic stuff with minimal variations for two decades, and come in off eighth record Tears on Tape. With that much stuff to draw on, including a few show stoppers, and a track record here in TO of delivering good shows, no wonder this one's sold out. Danforth Music Hall, doors 7 p.m.
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Florida State quarterback Christian Ponder (right) gains yardage as he moves around Oklahoma linebacker Tom Wort (top left) and defensive back Tony Jefferson (bottom left) in the first quarter of an NCAA college football game in Norman, Okla., Saturday, Sept. 11, 2010.
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Secure your seat in one of our lounges to watch the Blues in European action.
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There are a range of products available offering you a chance to win big money prizes.
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VfL Wolfsburg (A) Thu 27 Nov 2014, 18:00, Europa League
09 June 2013 13:03
Goodison Park will be home to one of the best pitches in the country from next season with a full renovation currently underway.
Major preparations are already taking place ahead of the upcoming campaign with the Club installing a brand new system to help the team in its quest for glory.
Head groundsman Bob Lennon spoke with the Evertonian to explain what he and his team are doing to make sure the famous pitch is one of the finest in the Premier League.
"What we are doing this year is a full renovation of the pitch, which includes a new system called Desso Grassmaster. It's the same as Arsenal, Aston Villa and Wembley use. This will be the Rolls-Royce of pitches now and one of the state-of-the-art pitches in the county."
The installation of the system should see the pitch remain in top condition during periods of bad weather and throughout the winter months, with polyfibres punched into the roots to nit the turf together.
Lennon said: "We're doing this to hopefully give the pitch consistency through the year instead of just from summer through to Christmas time. All this bad weather we've had over the last couple of years has been a problem, so we've had to have a decent pitch this year."
New Everton manager Roberto Martinez is known for his passing style and attacking play and the introduction of the new system should help the team continue the attractive football that delighted the Goodison faithful throughout last season.
"The players are quite adamant about a good pitch because they go to places like Arsenal, Aston Villa, Manchester United and all these other places and they want the same system," added Bob. "We have to keep up with the rest of the league. This [Dessa Grassmaster] is what they had for the World Cup in South Africa and this system will be used for the next 20 to 30 years.
"It is state-of-the-art, so there will be nothing to improve on this one."
U21s gain Goodison experience, plus Kone and McAleny comebacks please coach.
Kone travels but Naismith remains on Merseyside.
Hull, QPR and Stoke all on general sale.
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RT @GraMcConnell: We've made the Eurotunnel - one step closer to Wolfsburg! @Everton Just a 7hr drive to go on the other side http://t.co/X…
Unsworth praises work ethic of @OfficielArounaK and @CMcAleny following their returns to the field last night. evertonfc.com/news/2014/11/2… #EFC
#EFCU21: Unsy says last night's Goodison outing will help prepare his side for Monday's free-entry game v Sunderland. evertonfc.com/news/2014/11/2…


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(805): View more from California
his cum tasted like old pizza and looked like old milk
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his cum tasted like old pizza and looked like old milk
If you stick your dick in my spaghetti, we're fighting.
All I know is that it's pretty damn mean to put a glass wall in a bar.
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i was way too optimistic last night... got back to my apartment and the porch light was still on, like i'd actually make it all the way home.
so why are there three stressed gay men and a bowl of vomit in the smoke room?
She counted 5,6,7,8 then intentionally kneed herself in the eye numerous times.
And the clouds opened up and the sex gods said I hate you alfalfa
i was like his sober eyes girls would come up to us, show us theirs and if approved by me blew him, if rejected they went to my truck with a bottle of patron
He fucked me so hard I might have to go to the hospital for internal bleeding
That girl from the bar sent me a text saying that she wants to wear my cock as a hat. A cock hat. Is that good or bad?
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Someone brought brownies to work and I was skeptical to eat one then I remembered I was at work and there is no way there is weed in them. Haha I'm blaming you for that.
I want to be "performing a disservice to society by actually wearing clothes in public" hot.


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Try the mushroom diet to lose the weight without losing your curves
It's not uncommon that during weight loss women's butts and breast sizes shrink along the way too, but the M-Plan diet promises to prevent that! Celebrities such as Kelly Osbourne and Katy Perry swear by the M-Plan, a diet which consists of replacing one meal a day with a mushroom infused dish.
The diet claims that in a matter of 14 days, you can drop up to a dress size, but STILL keep your sexy curves. You're probably wondering what it is about mushrooms that make them so great. Well, read on to find out!
Read more ¿Qué más?: Easy moon diet could help you lose up to 6 pounds in one day!
The way the M-Plan works is that you are required to replace a lunchtime snack or dinner with a mushroom dish. Mushrooms are high in protein and fiber, but low in calories making it an ideal vegetable to eat in large quantities.
Nutritionist Jeannette Jackson tells the U.K.'s Daily Mail that mushrooms are perfect to prevent us from snacking throughout the day. "The dietary fiber in mushrooms helps promote good bowel function leaving you feel more satisfied, so you won't go hungry again quickly," she explained.
Many celebrities have claimed that they have lost weight eating the veggie high in zinc, iron, and B vitamins on a daily basis. They also say its how their hair, skin, and nails stay healthy. Jackson mentions that she is aware that women want to lose weight but don't want to lose their boobs and butt, which makes mushrooms the ideal vegetable to eat.
The mushroom diet may help you lose weight and let you maintain the curves you want, but Jackson warns that it is more important to have a healthy, natural well-balanced diet as opposed to focusing on eating one vegetable. Sure its super powerhouse qualities make mushroom an excellent and cost effective food, but she warns that there is such thing as too much of a good thing.
Hmm, I enjoy eating mushrooms from time to time if they are seasoned a particular way, but eating them raw doesn't sound so appealing to me. I'm aware of the many nutritional benefits it provides, but is the M-Plan diet really worth trying? If you are really focused on losing weight but want to keep your boobs and booty this may be the perfect meal plan for you. I mean, the celebs who swear by it are the definition of svelte and curvy, so who knows, maybe it can work for you after all!
Image via Thinkstock
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Will Murphy
Founder/Managing Partner
Updated On : Sep 30, 2014
2040 Polk Street
Hollywood, FL 33020
HQ Phone: 954-922-3388
Email format for @murphyslawfirm.net
Direct Phone : Not Available
< 5
500k - 1 Million
SIC Code:
Will Murphy is the current Founder/Managing Partner. You can find Will Murphy's linkedin profile, phone numbers, wiki, twitter, and biography on Murphy's Law Firm, P.A's Lead411 profile, as well as Murphy's Law Firm, P.A email addresses with the @murphyslawfirm.net domain format. Will Murphy's email may or may not be inside the profile. Murphy's Law Firm, P.A is situated in Hollywood, FL. You can find their contact information on Lead411 categorized under Legal. Some possible email formats for Will Murphy are firstname.lastname@example.com, email@example.com, email@example.com, and firstname.lastname@example.com. If you sign up for our free trial you will see our firstname.lastname@example.com addresses.
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Will Maberry - Sales - Marketing
A Santa Rosa Beach, FL-based organization, Destin Real Estate Company is just one of the many Lead411 profiles that you can find contact information, like phone numbers and emails. Their profile includes @destinproperties.com email addresses, as well as details on Will Maberry's email, the organization's Marketing Director. Their profile can be found in Unknown category. If you also need twitter, facebook, linkedin, wiki, and biography details for Will Maberry, you can also find them in Lead411. Some possible email formats for Will Maberry are email@example.com, email@example.com, firstname.lastname@example.com, and email@example.com. If you sign up for our free trial you will see our firstname.lastname@example.com addresses.
Will Montanaro - Executive
Rutgers Athletic Development's Dir Development, Major Gifts is Will Montanaro. They are based in New Brunswick, NJ, and you can find their Lead411 profile filed under the Non-profit industry. Will Montanaro's profile contains twitter, phone numbers, linkedin, wiki, and biography information, and you can also find other Rutgers Athletic Development contact information and email addresses on Lead411 with the @scarletknights.com domain format. Some possible email formats for Will Montanaro are firstname.lastname@example.com, email@example.com, firstname.lastname@example.com, and firstname.lastname@example.com. If you sign up for our free trial you will see our email@example.com addresses.
Will Mcnabb - Executive
A Manager at Crow's Nest Marina Restaurant based in Venice, FL, Will Mcnabb has a comprehensive profile on Lead411. You can find the entry on Crow's Nest Marina Restaurant in our Restaurants category. The company CEO is . There are email addresses on their profile and may include Will Mcnabb' email format too. You can also find other contact information like facebook, phone numbers, biography, wiki, and linkedin for Will Mcnabb. Some possible email formats for Will Mcnabb are email@example.com, firstname.lastname@example.com, firstname.lastname@example.com, and firstname.lastname@example.com. If you sign up for our free trial you will see our email@example.com addresses.
People Directory > Will Murphy


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When Freeway released his sophomore album, Free At Last, last November, widespread critical praise followed. In this era of cookie-cutter rap, Free distinguished himself as one of a few major emcees who puts his whole being into his work. On the newest buzz single from his upcoming junior album, Freedom of Speech, the Philly veteran steps up his metaphor game by comparing The Block in his hometown to a woman; though she had been there to support him for many years, he left her once the major fame and fortune came. Now independent once again, Free is ready to turn down all the big-time offers because he has his Baby Back. Produced by Blunt and featuring a short interpolation of the Chili's restaurant jingle (near the end), Baby Back (The Block) leaves no doubt that Free is loyal to his streets.
Written by Burmy on 10/7/08
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He's a game changer, I think,
Submitted by wacko bird on Sat, 07/26/2014 - 14:48. Permalink
He's a game changer, I think, cause he has the credibility to be taken seriously. There's a Geneva speech on YouTube you should watch too.
I must be willing to give up what I am in order to become what I will be. Albert Einstein
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#1 Oceanside 38 - Carlsbad 0 in the San Diego Section CIF Quarterfinals of the Open Division! A complete and total Pirate Shut … [Read more...]
Pirates Show Why They're Ranked No. 1 In Win Over Carlsbad
OHS Senior Selected to March with Prestigious U.S. Army Band
The U.S Army All-American Bowl is more than just a football game for the best high school players. It's also about some of the nation's best high … [Read more...]
Dr. Duane Coleman Goes to Washington
An Announcement from the Oceanside Unified School District Congratulations to OUSD Superintendent Dr. Duane Coleman for being chosen as one of only … [Read more...]
OHS Football Athletes Accept Early Scholarship Offers
It's exciting to have a 10-0 Pirate varsity football team for Fall 2014! So it is no doubt, the talented, outstanding Senior players on the team are … [Read more...]
OHS Wrestling Benefit Dinner a Success
Parents, friends, and fans of OHS wrestling had a great night of comic relief, musical talent and delicious Hawaiian BBQ while supporting your … [Read more...]
OHS Drama "ALMOST, MAINE" performances most favorable
Oceanside High School's Drama Department presented "Almost, Maine" on November 14-15 at the Oceanside Sunshine Brooks Theatre. "Almost, Maine" is a … [Read more...]
#1 Oceanside takes down El Camino, Nov. 7
Not this year WILDCATS! Oceanside defeats the El Camino Wildcats on November 7! Varsity, JV & Freshman football all WIN! OHS pride of owning … [Read more...]
OHS Tile Project
The Oceanside High School Foundation invites you to be part of a very special commemorative project. In September 2008, a beautiful, permanently … [Read more...]
OHS Banner Information
These Oceanside High School athletic banners were proudly displayed in the OHS gym for many years. Upon the renovation of the gym a few … [Read more...]
2014 Hall of Fame Ceremony
The Oceanside High School Foundation celebrated our ninth annual Hall of Fame induction ceremony celebrating over a hundred years of Pirate Pride. … [Read more...]


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text: We had a wonderful tour leader named Harris Hardy for our tour of the Canyon, Harris's grandmother has a plot of land in the park so he had personal experiences he told us about. We had 6 people in our tour. Go for the smaller group tour. Wonderful time learning about the Navajo culture and traditions. Harris was outstanding! Small... More


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NEW YORK: Calling Rajat Gupta a "flight risk" due to his strong personal and financial ties to India, US prosecutors have asked a court here to reject the former Goldman Sachs director's request to remain free on bail pending appeal of his conviction on insider trading charges.
Gupta, who was sentenced last month to two years in prison, had appealed in the US Second Circuit Court of Appeals to grant him bail pending appeal and had asked for a stay on his surrender date. The former McKinsey head is set to begin his jail term on January 8 next year.
In a memorandum submitted on Monday by US Attorney in Manhattan Preet Bharara and federal prosecutors Reed Brodsky and Richard Tarlowe, the government said Gupta's request for a stay of his surrender date and release pending appeal should be denied.
The prosecutors said Gupta "poses a risk of flight" due to his "strong ties overseas, including assets, family, and close friends in India."
Interest Networkitimes | Email


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Tags 1960s, springtime
Genres classic rock, 60s, rock, rockabilly, oldies (beta)
(flag as incorrect)
April 23, 2012
Tunes about change and tunes from the '60s.
where did you get the pic from????????
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Might be my favourite mix of all time. Love the Rookie mixes!
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Amazing Tavi
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Friday Playlist: Arm in Arm by RookieMag
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best friends, friendship, friend love
Slumber Party by RookieMag
Dreamy songs to play at a sleepover, while the world outside fades away.
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Hanging Out With Angela Chase and Rayanne Graff by RookieMag
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Ap-parent-ly Scary Songs by RookieMag
A Halloween playlist by cool dad Steve Gevinson.
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text:
» Business
AirAsia targets 17-20% growth in capacity
Publication Date : 22-01-2013
AirAsia Bhd is targeting 17 to 20 per cent capacity growth for this year.
Chief executive officer Aireen Omar said the growth should be in line with its workforce's growth to cater to its expansion plan.
"We are taking in 10 aircraft this year and are growing substantially. This would stimulate traffic for the group.
"We will see an increase in flight frequencies as well as new destinations from our existing points and to points that have been established by our affiliates within the region," Aireen said.
She was speaking to reporters after the signing of a partnership agreement between AirAsia and Manipal International University, an entity of Manipal Education Malaysia (MEM), for human capital development and upscaling of human talent competencies in Malaysia.
Aireen said each new aircraft would require 40 additional workers and that there was a need for a steady supply of human capital that covered all aspects of the businesses to meet rising demand.
"We believe the venture will not only benefit Malaysia but we are also focusing on regional growth," she said.
At the moment, AirAsia has 10,000-strong workforce in the region, with 5,000 to 6,000 of them in Malaysia.
"We are looking at building a pipeline of potential employees for AirAsia and we will work with AirAsia in aligning the relevant syllabus with competencies and soft skills prescribed by the the organisational culture of AirAsia," said Manipal Education Malaysia managing director and chief executive officer Iskandar Mizal Mahmood.
Iskandar said MEM provided a suite of education facilities and services with total investments of over 650 million ringgit (US$213.49 million) and that the first phase of its over 140-acre campus in Nilai was now open.
"This year, we are hoping to seal several partnerships which include five global giant companies and four local firms," he said.
» Other Business
● TACLOBAN CITY: Sign of confidence in Tacloban: Opening of SM store
● KUALA LUMPUR: AirAsia X may need more funds, say analysts
● KUALA LUMPUR: Malaysia woos back the Chinese
● HANOI: Vietnam eyes law to give foreigners right to purchase homes
● HONG KONG: 95% SMEs affected by 'Occupy', says survey
● BANGKOK: Wage hike for some, job loss for many others
● SINGAPORE: Beauty ads accused of using ugly tricks
● SHANGHAI: Chinese shoppers rediscover the joy of retail outlets
● BANGKOK: 3 Thai industries noted as having global potential
● TOKYO: Abe's fiscal goals depend on continuous wage hikes
● KATHMANDU: World Bank to invest US$130 million in Nepal's solar plants
● BANDAR SERI BEGAWAN: Asean financial integration faces challenges: Analyst
● BANDAR SERI BEGAWAN: Visa, lack of flights block Asean aviation integration
● KATHMANDU: Cross-border power trade: Nepal, India agree to devise long-term plans
● SAN FRANCISCO: Alipay brings the frenzy of Black Friday to China
» Most Viewed
● MANILA: Filipino? Or just Filipino-looking Asian?
● BANGKOK: Thai junta flayed over crackdown on rebellious 'Hunger Games' salute
● SEOUL: 180,000 Koreans in America are undocumented
● SINGAPORE: Asia poised to enter 'new golden era'
● BANGKOK: I'm not a dictator, says angry Thai PM
● BANGKOK: Three-way strife may be likely now
● SEOUL: Korea, Japan to resume sex slavery talks
● BEIJING: Beijing to build air corridors to blow away pollution
● SHANGHAI: Chinese shoppers rediscover the joy of retail outlets
● TAIPEI: Taiwan's ability to sign FTAs in doubt, says US
● TOKYO: Abe seeks voters' verdict on Abenomics
● BANGKOK: 3 Thai industries noted as having global potential
● TOKYO: Dialogue with China necessary for boosting Hong Kong's autonomy
● TOKYO: Abe sends legislators home in 'Abenomics dissolution'
● SEOUL: Illegal Chinese fishing


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Created: 07/11/2014 10:27 AM WDIO.com
NEW YORK (AP) - Chrysler says it is recalling 651,000 Jeep and Dodge SUVs in the U.S. because vanity mirror lights that have undergone repairs can short circuit and start a fire if not reassembled correctly.
The recall is for certain 2011 to 2014 Jeep Grand Cherokee and Dodge Durango models. Chrysler says it has seen the problem only in lighted sun visor mirrors that have been repaired. But as a precaution, it says the recall applies to all of the vehicles.
The automaker says it knows of three injuries caused by the lighted mirror.
Chrysler will contact customers and let them know when they can have the problem fixed.
The recall will total 895,000 SUVs around the world. About 45,000 are in Canada, 23,000 are in Mexico and 175,000 are outside North America.
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
Licenses, Deer Population Down for Wisconsin Deer Opener
The Wisconsin firearm deer hunting tradition got off to a safe start as Department of Natural Resources officials said they had received no reports of accidental shootings or other injuries by mid-afternoon Sunday on the opener of the state's nine-day gun deer hunt.
Northlanders Give Back in Preparation for Holiday Season
Northlanders gave back on Saturday in preparation for the holiday season. It was Family Volunteer Day at the Duluth Library, and folks participated in several friendly projects.
"By Us, For Us" Meeting to Discuss Vision for Equity in Duluth
Duluth's Native and African heritage communities came together on Saturday to share experiences and ideas at the 1st United Methodist Church. The meeting called "By Us, For Us" invited people of color, African Americans and Native Americans to come together to break bread and learn about each other culturally.
MNsure Enrollments, Renewals Approach 8,000
Minnesota's health insurance exchange says it has enrolled nearly 8,000 Minnesotans in health plans in the first week of open enrollment this fall. The deadline for enrolling in coverage that takes effect Jan. 1 is Dec. 15.
Wisconsin Gun Deer Hunt Begins
The season opened as the sun rose Saturday and will run through Nov. 30. Forecasts for opening weekend called for freezing rain and fog with highs ranging from the upper 30s to the low 40s both days.


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A week after enlisting former Florida Gov. Jeb Bush in his campaign for education reform, Gov. Bob McDonnell is calling on another prominent fellow Republican.
The Lafayette Parish School System announced late Thursday afternoon that two students ages 14 and 17 were taken into police custody after allegedly making threats to bring a gun to campus Friday.
Louisiana cannot execute a DeSoto Parish man next week because the state has provided too little information about the drug that will be used in the lethal injection and the execution methods, a federal judge ruled Thursday.
A federal judge has agreed to cut short former Louisiana Gov. Edwin Edwards' court supervision following his release from prison.
Twenty-twelve was a year that will stay etched in the collective memory of Lafayette for years to come. For Police Chief Jim Craft, it'll hopefully be one of those years you can look back on a decade from now and call an anomaly.
Paying a lawn service to mow your yard? Storing your boat at a marina? Contracting with someone to repair your roof? Getting cable or satellite TV piped into your house?
The Department of Revenue has chosen Ernst & Young to analyze calculations used to design Jindal's tax proposal. Jindal is proposing to get rid of state income taxes, in exchange for higher sales taxes and other tax code adjustments.
The Big Easy is one of more than a dozen cities where the show's nationwide search for its next big act will be held.
The Missouri Republican Party says Jindal is to speak Feb. 16 at a banquet for its annual Lincoln Days conference in St. Louis. Jindal also was a keynote speaker during the Missouri Lincoln Days event last year in Kansas City.
State Sen. Elbert Guillory, D-Opelousas, must be a busy man; that would explain why he was a no-show at a recent meeting in Alexandria, where 36 educators from around the state gathered to hear his keynote speech.
City-Parish President Joey Durel spoke for about 45 minutes to a packed Cajundome Convention Center for his annual State of the Parish address, getting in a good-natured poke at newly elected City-Parish Council Chairman Brandon Shelvin that greatly delighted us.
NOV 26 Zach Kopplin, who we came to know and love when he was a Louisiana high school student lobbying for the continued inclusion of science stuff in science class, pens this post in The Atlantic about a "textbook" available for social studies instruction in Texas that discusses how Moses contributed to the Constitution. (Oy! Texas rednecks love Jews. Who knew?)
NOV 26 Finally, mad people on the interwebz is a good thing! World wide webby outrage has caused the village of Moreauville to reverse its plan to confiscate pit bulls and Rottweillers and euthanize them simply because of their breed, WAFB reports here. The plan? They're going to enforce the leash law. Well, that would have been a good place to start.
NOV 26 Jim Brown, like many of us Louisiana voters, seems fed up with out of town know-it-alls trying to tell us what to do. Bill Cassidy can't make it through the day without flying someone in to "tell us political retards" how to vote, he says.
NOV 26 Blogger Tom Aswell is writing about the behavior of the two finalists in the 6th Congressional District race: Edwin Edwards and Garret Graves. Edwards has come out swinging, but Graves' campaign seems bent on snatching defeat from the jaws of victory, Tom says.
NOV 26 Blogger CB Forgotston is confused, he says, because Governor Bobby Jindal said higher education wouldn't get cut, but it looks like it is being cut. CB's asking: When is a cut not a cut?
NOV 26 Unless you're in Virigina, you shouldn't count on seeing our Governor on Election Day. Mark Ballard writes in the Advocate's political blog that Bobby will be appearing at a GOP love fest of some kind there, instead of spending the day here.
NOV 26 This post on The Lens takes a look at the ongoing dispute in New Orleans over the banners about the upcoming tax election for the school system. The banners are hanging on schools, and some feel they are promotional, which is not allowed, instead of educational - which is allowed.
NOV 26 Not all college students are focused on football games and parties at this time of year. This post on DIG Baton Rouge recounts an LSU student group that tries to make sure that those who are hungry and homeless are not forgotten by those of us who aren't.


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(707): View more from California
I thought she was going to get passionate and throw her on the bed and fuck her, but she just started breaking stuff.
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I thought she was going to get passionate and throw her on the bed and fuck her, but she just started breaking stuff.
New boss looks like john cusack in a collar. Hot. Why do i always want to have sex with priests?
I'm pretty sure he came before I knew he was inside me.. Didn't think that was his plan when he said he was gonna do things I've never experienced before
we've been dating more than a month and i just realized there's no hair on his chest..
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So how many licks to the face does it take to get kicked out of the bar?
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he said i balance and complete him. i feel sick
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Judge me all you want, but while you are stuck at home eating Ramen and tap water, I will be dining with some guy who, although might be the same age as my father, is filthy rich.
to instagram or to not instagram the picture i took of when i shit in the urinal
My roommate was tripping balls last night, he kept me up all fucking night
All's fair in love and war. and tinder.