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|By PR Newswire
Article Rating:
|January 8, 2013 03:01 AM EST
PARIS, January 8, 2013 /PRNewswire/ --
SAGEMCOM, LEADER DU MARCHE DES PASSERELLES MULTIMEDIA RESIDENTIELLES EN EUROPE, DEVOILE AU CES 2013 A LAS VEGAS, LA NOUVELLE BOX SAGEMCOM F@ST 3965 Air INTEGRANT UN MODEM LTE.
Après de nombreux déploiements basés sur les technologies 2G et 3G, Sagemcom annonce sa nouvelle génération de passerelles résidentielles mobiles LTE.
(Photo: http://photos.prnewswire.com/prnh/20130108/586518 )
(Logo: http://photos.prnewswire.com/prnh/20121017/568139 )
Cette nouvelle génération de produits permet aux opérateurs d'offrir des services Triple-Play (data, téléphonie, TV) résidentiels très haut débit via leur réseau mobile LTE.
Basé sur le savoir-faire et l'expérience de Sagemcom, le F@st 3965 Air offre tous les services haut débit résidentiels d'un produit à forte valeur ajoutée. La richesse des interfaces tels que le Wi-Fi 802.11n dual band 2,4&5GHz, les ports USB ou le routage gigabit Ethernet permettent de connecter l'ensemble des terminaux de la maison. Grâce à son logiciel éprouvé, le F@st 3965 Air est contrôlable à distance, via TR069, ou localement via une interface web. Les fonctionnalités DLNA ou stockage dans le Cloud en font un produit multimédia essentiel dans la maison.
« Les performances du LTE tant en débit qu'en couverture permettent aux opérateurs d'offrir des services résidentiels comparables à ceux offerts sur les lignes fixes. Les solutions Sagemcom permettent de bénéficier du meilleur des deux univers », explique Ahmed Selmani, Directeur Général délégué de Sagemcom Broadband.
Le F@st 3965 Air offre des débits jusqu'à 100Mbps en LTE, ou 42Mbps en 3G, si le réseau LTE n'est pas activé. Deux variantes sont disponibles pour couvrir l'ensemble des bandes de fréquences et répondre ainsi aux besoins des opérateurs à travers le monde.
A propos de Sagemcom
Groupe français de haute technologie à dimension internationale, Sagemcom opère sur les marchés du haut-débit (maison numérique, décodeurs, box Internet, téléphonie et terminaux multimédia), des télécoms et de l'énergie (infrastructures télécoms, compteurs communicants et management de l'énergie), et de la gestion de documents (terminaux d'impression, logiciels et solutions, dématérialisation).
Avec un chiffre d'affaires de près de 1,3 milliard d'euros, Sagemcom emploie 4 600 personnes sur les cinq continents ; leader européen sur la plupart de ses marchés clés, Sagemcom a pour ambition de devenir un des leaders mondiaux des terminaux communicants à forte valeur ajoutée.
Sagemcom est fortement engagé dans le développement durable à travers le cycle de vie de ses produits : éco-conception, consommation d'énergie, charte éthique responsabilisant l'ensemble de ses fournisseurs.
Pour plus d'informations : http://www.sagemcom.com
The 3rd International Internet of @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that its Call for Papers is now open. The Internet of Things (IoT) is the biggest idea since the creation of the Worldwide Web more than 20 years ago.
Nov. 28, 2014 10:00 AM EST Reads: 1,036
Cultural, regulatory, environmental, political and economic (CREPE) conditions over the past decade are creating cross-industry solution spaces that require processes and technologies from both the Internet of Things (IoT), and Data Management and Analytics (DMA). These solution spaces are evolving into Sensor Analytics Ecosystems (SAE) that represent significant new opportunities for organizations of all types. Public Utilities throughout the world, providing electricity, natural gas and water, are pursuing SmartGrid initiatives that represent one of the more mature examples of SAE. We have s...
Nov. 27, 2014 04:00 PM EST Reads: 1,282
The security devil is always in the details of the attack: the ones you've endured, the ones you prepare yourself to fend off, and the ones that, you fear, will catch you completely unaware and defenseless. The Internet of Things (IoT) is nothing if not an endless proliferation of details. It's the vision of a world in which continuous Internet connectivity and addressability is embedded into a growing range of human artifacts, into the natural world, and even into our smartphones, appliances, and physical persons. In the IoT vision, every new "thing" - sensor, actuator, data source, data con...
Nov. 27, 2014 04:00 PM EST Reads: 1,630
The Internet of Things is tied together with a thin strand that is known as time. Coincidentally, at the core of nearly all data analytics is a timestamp. When working with time series data there are a few core principles that everyone should consider, especially across datasets where time is the common boundary. In his session at Internet of @ThingsExpo, Jim Scott, Director of Enterprise Strategy & Architecture at MapR Technologies, discussed single-value, geo-spatial, and log time series data. By focusing on enterprise applications and the data center, he will use OpenTSDB as an example t...
Nov. 27, 2014 03:00 PM EST Reads: 1,464
How do APIs and IoT relate? The answer is not as simple as merely adding an API on top of a dumb device, but rather about understanding the architectural patterns for implementing an IoT fabric. There are typically two or three trends: Exposing the device to a management framework Exposing that management framework to a business centric logic Exposing that business layer and data to end users. This last trend is the IoT stack, which involves a new shift in the separation of what stuff happens, where data lives and where the interface lies. For instance, it's a mix of architectural styles ...
Nov. 27, 2014 03:00 PM EST Reads: 1,298
An entirely new security model is needed for the Internet of Things, or is it? Can we save some old and tested controls for this new and different environment? In his session at @ThingsExpo, New York's at the Javits Center, Davi Ottenheimer, EMC Senior Director of Trust, reviewed hands-on lessons with IoT devices and reveal a new risk balance you might not expect. Davi Ottenheimer, EMC Senior Director of Trust, has more than nineteen years' experience managing global security operations and assessments, including a decade of leading incident response and digital forensics. He is co-author of t...
Nov. 27, 2014 01:00 PM EST Reads: 1,663
The Internet of Things will greatly expand the opportunities for data collection and new business models driven off of that data. In her session at @ThingsExpo, Esmeralda Swartz, CMO of MetraTech, discussed how for this to be effective you not only need to have infrastructure and operational models capable of utilizing this new phenomenon, but increasingly service providers will need to convince a skeptical public to participate. Get ready to show them the money!
Nov. 27, 2014 11:00 AM EST Reads: 1,277
The Internet of Things will put IT to its ultimate test by creating infinite new opportunities to digitize products and services, generate and analyze new data to improve customer satisfaction, and discover new ways to gain a competitive advantage across nearly every industry. In order to help corporate business units to capitalize on the rapidly evolving IoT opportunities, IT must stand up to a new set of challenges. In his session at @ThingsExpo, Jeff Kaplan, Managing Director of THINKstrategies, will examine why IT must finally fulfill its role in support of its SBUs or face a new round of...
Nov. 27, 2014 10:00 AM EST Reads: 1,221
One of the biggest challenges when developing connected devices is identifying user value and delivering it through successful user experiences. In his session at Internet of @ThingsExpo, Mike Kuniavsky, Principal Scientist, Innovation Services at PARC, described an IoT-specific approach to user experience design that combines approaches from interaction design, industrial design and service design to create experiences that go beyond simple connected gadgets to create lasting, multi-device experiences grounded in people's real needs and desires.
Nov. 27, 2014 08:00 AM EST Reads: 1,231
Enthusiasm for the Internet of Things has reached an all-time high. In 2013 alone, venture capitalists spent more than $1 billion dollars investing in the IoT space. With "smart" appliances and devices, IoT covers wearable smart devices, cloud services to hardware companies. Nest, a Google company, detects temperatures inside homes and automatically adjusts it by tracking its user's habit. These technologies are quickly developing and with it come challenges such as bridging infrastructure gaps, abiding by privacy concerns and making the concept a reality. These challenges can't be addressed w...
Nov. 27, 2014 07:45 AM EST Reads: 1,511
The Domain Name Service (DNS) is one of the most important components in networking infrastructure, enabling users and services to access applications by translating URLs (names) into IP addresses (numbers). Because every icon and URL and all embedded content on a website requires a DNS lookup loading complex sites necessitates hundreds of DNS queries. In addition, as more internet-enabled 'Things' get connected, people will rely on DNS to name and find their fridges, toasters and toilets. According to a recent IDG Research Services Survey this rate of traffic will only grow. What's driving t...
Nov. 27, 2014 07:00 AM EST Reads: 1,487
Scott Jenson leads a project called The Physical Web within the Chrome team at Google. Project members are working to take the scalability and openness of the web and use it to talk to the exponentially exploding range of smart devices. Nearly every company today working on the IoT comes up with the same basic solution: use my server and you'll be fine. But if we really believe there will be trillions of these devices, that just can't scale. We need a system that is open a scalable and by using the URL as a basic building block, we open this up and get the same resilience that the web enjoys.
Nov. 27, 2014 06:45 AM EST Reads: 1,384
Connected devices and the Internet of Things are getting significant momentum in 2014. In his session at Internet of @ThingsExpo, Jim Hunter, Chief Scientist & Technology Evangelist at Greenwave Systems, examined three key elements that together will drive mass adoption of the IoT before the end of 2015. The first element is the recent advent of robust open source protocols (like AllJoyn and WebRTC) that facilitate M2M communication. The second is broad availability of flexible, cost-effective storage designed to handle the massive surge in back-end data in a world where timely analytics is e...
Nov. 27, 2014 06:45 AM EST Reads: 1,319
We are reaching the end of the beginning with WebRTC, and real systems using this technology have begun to appear. One challenge that faces every WebRTC deployment (in some form or another) is identity management. For example, if you have an existing service – possibly built on a variety of different PaaS/SaaS offerings – and you want to add real-time communications you are faced with a challenge relating to user management, authentication, authorization, and validation. Service providers will want to use their existing identities, but these will have credentials already that are (hopefully) i...
Nov. 27, 2014 04:00 AM EST Reads: 1,228
"Matrix is an ambitious open standard and implementation that's set up to break down the fragmentation problems that exist in IP messaging and VoIP communication," explained John Woolf, Technical Evangelist at Matrix, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Nov. 27, 2014 04:00 AM EST Reads: 1,176
P2P RTC will impact the landscape of communications, shifting from traditional telephony style communications models to OTT (Over-The-Top) cloud assisted & PaaS (Platform as a Service) communication services. The P2P shift will impact many areas of our lives, from mobile communication, human interactive web services, RTC and telephony infrastructure, user federation, security and privacy implications, business costs, and scalability. In his session at @ThingsExpo, Robin Raymond, Chief Architect at Hookflash, will walk through the shifting landscape of traditional telephone and voice services ...
Nov. 26, 2014 02:00 PM EST Reads: 1,611
Explosive growth in connected devices. Enormous amounts of data for collection and analysis. Critical use of data for split-second decision making and actionable information. All three are factors in making the Internet of Things a reality. Yet, any one factor would have an IT organization pondering its infrastructure strategy. How should your organization enhance its IT framework to enable an Internet of Things implementation? In his session at Internet of @ThingsExpo, James Kirkland, Chief Architect for the Internet of Things and Intelligent Systems at Red Hat, described how to revolutioniz...
Nov. 24, 2014 07:00 PM EST Reads: 1,716
Bit6 today issued a challenge to the technology community implementing Web Real Time Communication (WebRTC). To leap beyond WebRTC's significant limitations and fully leverage its underlying value to accelerate innovation, application developers need to consider the entire communications ecosystem.
Nov. 24, 2014 12:00 PM EST Reads: 1,620
The definition of IoT is not new, in fact it's been around for over a decade. What has changed is the public's awareness that the technology we use on a daily basis has caught up on the vision of an always on, always connected world. If you look into the details of what comprises the IoT, you'll see that it includes everything from cloud computing, Big Data analytics, "Things," Web communication, applications, network, storage, etc. It is essentially including everything connected online from hardware to software, or as we like to say, it's an Internet of many different things. The difference ...
Nov. 24, 2014 11:00 AM EST Reads: 1,746
Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world.
Nov. 24, 2014 09:00 AM EST Reads: 1,782


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3.8 / 54 reviews
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4.0 / 51 reviews
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2.0 / 51 reviews
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3.0 / 51 reviews
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3.0 / 52 reviews
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1 Swansea Marriott Hotel
Maritime Quarter Map
Rate includes breakfast
In the bustling Maritime Quarter on the enchanting Swansea Bay, the Swansea Marriott Hotel captures the charm and beauty of its Gower peninsula surroundings. A gentle stroll to the city centre... More
Nice & relaxing after a 5 hour journey
2 Mercure Swansea Hotel
Phoenix Way Map
Save 30% on your stay
Enjoy tranquil lake views at the Mercure Swansea Hotel, a gateway to the Brecon Beacons and Gower Peninsula. This 3-star Swansea hotel is set in landscaped grounds, 3 miles from the city centre.... More
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Port Talbot Map
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family weekend away
4 Norton House Hotel
17, Norton Road, Mumbles Map
Advance Purchase - SAVE 15%
Built in 1790 and now run as a 3* Hotel offering 18 en-suite bedrooms and 4 self-catering apartments. Norton House Hotel is a traditional, classic style building, set in spacious gardens, close to... More
Good place to stay
The hotel has an impressive Health & Fitness Club with its 18m indoor heated swimming pool, sauna and therapy rooms.Complimentary car parking is also available. A 7 storey modern building in a... More
6 The Gower Hotel
11 Church Lane Map
Situated close to both Swansea and the areas many beautiful beaches, this luxurious boutique Hotel offers fine dining, comfortable accommodation and free Wi-Fi and parking.A charming and quirky... More
7 Travelodge Swansea M4
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Junction 47 M4 Motorway near Swansea. More
For the money???
8 ibis Swansea
Fabian Way Map
Ibis Hotel Swansea is a budget Hotel located in Central Swansea.Your Hotel booking puts you close to the SA1 Waterfront Development, easy access to the city's shopping and entertainment districts.... More
9 Travelodge Swansea Central
Princess Way Map
Exit the M4 at J42, continue ahead onto A483 & continue onto the A4067, after Sainsbury's take right hand lane into Wind Street , after 500yds turn left into St Mary's Street & follow around into... More

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Holdays.net Home
Jewelry Sale
All sales Start @ .99 cents
See our other Sterling Silver Jewelry
Up for your Consideration ........
Is This Vintage Old Pawn NAVAJO MADE Heavy Solid Overlay Sterling Silver Concho Belt.
Made by Navajo Willie A. Yazzie Jr. (Willie the Dipper). Willie Specialized in Silver Overlay Work and began producing in the 1950's. Worked for M.L.Woodard. Willie shared the Dipper Makersmark with his father, but we believe this piece is a little to recent to have been made the Senior Yazzie.
About the belt......
14 Conchos, each Overlaidin Sterling Silver, each with a different Native American Motif.
Motifs include Bear Paw, Sun Face, Kokopelli, Thunder Clouds, Maize and many more. (see photo's).
Fantastic Overlay work by a Master Navajo Silversmith
Beltis35 1/2inches long.
Concho Belt Buckle Center Piece is 2 inches across, the other Conchos are 1 1/2 inches across.
Buckle is Stamped Sterling and has Medicine Man Dipper Symbol, the other Conchos have the only the Medicine Man Dipper Makersmark and tested as Sterling.
Total Weightis HEAVY 168.7 Grams.
InVery GoodVintageCondition with no dents or gouges.Minimal light scuffs can be polished up.
This is a Unique CONCHO BELT Museum Quality.
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Thank you for your time and good luck offerding.
14 Day Money Back if not 100% satisfied with your purchase.
We combine shipping.
This item has been shown 0 times.
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2014 Reader Survey: College Sports Sherman Critical Of Several NFL Policies MASN Taking Aim At MLB Advance To Nats NHL, NHLPA Aim For Big Money World Cup Red Sox Willing To Go Over Luxury Tax Threshold Silver Optimistic About New Bucks' Arena Bahamas Hosting CBB Despite Gambling Executive Transactions 2014 Reader Survey: Motorsports Jeter Played No Role In Woods' Tribune Piece
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Shining StarPublished in SportsBusiness Journal on 11 / 24 / 14
The Dallas Cowboys are moving ahead in developing a cutting-edge training and mixed-use complex that will strengthen their ties in north Texas through a partnership with the city of Frisco and the local school district. In the planning stages for the past two years, the ambitious project could co...
Tags: Facilities
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SportsBusiness Journal: Family section drives K-State work
Kansas State, nestled in the heart of the Wheat Belt, went against the grain to develop the newest expansion to Bill Snyder Family Stadium. A rendering shows the new north end zone at Bill Snyder Family Stadium, set to open in 201 ...
Tags: Facilities
SportsBusiness Daily: Vikes Pleased With Stadium Builders License Revenue
The Vikings have generated about $30M in Stadium Builders License revenue for their new stadium development, far exceeding projections for the first two months of the program, according to officials with Van Wagner Sports & Entertainment, the team's sales agency. Since launching a high-tec ...
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SportsBusiness Daily: Vikings Set Strong Seat License Sales Pace
The Vikings have generated about $30M in Stadium Builders License revenue for their new stadium development, far exceeding projections for the first two months of the program, according to officials with Van Wagner Group, the team's sales agency. Since launching a high-tech preview center of p ...
SportsBusiness Daily: TD Garden Set For Redeveloped Legends Club
The soon-to-be redeveloped Legends Club at TD Garden will bring a contemporary look to the premium space tied to digital technology and a revamped food program. Delaware North Boston, the arena's owner/operator, shared images exclusively with THE DAILY and discussed the project ahead of ...
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SportsBusiness Journal: Teams push mobile ticketing
By any measure, the Atlanta Braves took a big risk this season by essentially forcing their season-ticket holders to embrace mobile ticketing. Mobile ticketing adoption rates across the sports industry are estimated in the low double-digit percentages at best, even after more than a half decade o ...
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SportsBusiness Journal: Live Nation talks digital
Live Nation Entertainment, the world's largest ticket provider and event promoter, has enjoyed a front-row seat as the market shifts toward digital ticketing. Last year, Live Nation Entertainment, a company that includes Ticketmaster, a provider to dozens of major league facilities, sold 21 ...
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SportsBusiness Journal: New board to change Churchill
This year's Kentucky Derby will redefine the fan experience in horse racing, thanks to the track's massive new video board, say officials with Churchill Downs and Van Wagner Big Screen Network, the board's content provider. Over the past weekend, the track was to unveil its new ...
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The Casio Tryx hits the market with an intriguing design that tests our preconceptions about camera design (and our ability to refrain from making puns about sleeves). Armed with a 12.1-megapixel backlit CMOS sensor and a 3-inch touchscreen, the Tryx (official designation EX-TR100) certainly turns heads thanks to its design.
The Tryx sports an innovative frame that rotates freely from the rest of the camera, allowing for nearly limitless ways to hang, mount, handle, and hold your new point-and-shoot camera. This isn't a camera with bags of custom options or impressive performance, but its design at least forces you to re-think what kind of shots your camera is capable of capturing.
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Hayley Beresford (AUS) on Rebena-W
2008 Hanovarian mare by Rosario
Hayley Beresford (AUS) on Rebena-W
2008 Hanovarian mare by Rosario
Rosario - Argentina (von Nico Giraldez)
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Los hermanos
model: Nana Ichigo.
Messi com fãs na Argentina
Leo with fans in Rosario
Boardwalk #rosario #argentina #redviajar #bdviajes (en Rosario - Sta Fe - Argentina)
Messi com um fã em Rosário
Back in Rosario
"What do you want me to tell you? I already said everything", Leo says when he's asked about the absorbed feelings, days away from the World Cup Final we lost against Germany last Sunday. And he laughs, cheeky, just as he is inside the pitch. He looks at the rival first, this journalist, he checks her out from top to bottom, he doesn't trust her, and when she presses a little bit he just answers once again, "That's it! There's nothing else to say". "But this is your town Leo, could you say anything for the people who supported you here?". It doesn't work. He doesn't dribble because he's carrying his suitcase. Either way, he doesn't need to. He looks ahead and goes out fast, the field is open for him, all of it. Even his wife Antonella Roccuzzo is left behind. But it doesn't matter because those few bystanders in the airport are desperate to reach him, until he climbs into a black SUV at the parking lot. "Thanks crack!", says lovingly one of the few people who got a picture in the end.
Ghostly train station (Estación de tren fantasma) | Rosario | Santa Fé | Argentina
You won't believe what I found in my town's exhibition for Batman's 75th anniversary.
Yes! Young justice action figures! I couldn't believe my eyes
EDIT: Wait, there's more! Stupid phone didn't let me add the other one. Robin in his stealth suit. I think… or just badly painted? and because they didn't have a Zee one, I took a pic of the animated series collection <3
Rosario Dawson
Rhapsody Magazine - August 2014
Photographer - Tony Duran
Makeup - Kara Yoshimoto Bua / Starworks Artists
Monument to the Flag (Monumento a la Bandera) | Rosario | Santa Fé | Argentina
Alan, in the memorable photo with Leo Messi. (Photo: Arroyo News)
Last Friday Messi stopped to refuel his truck in General Lagos. The Barcelona star took pictures and signed autographs for all who came.
Here approached Alan, a boy who sells fried pies, and took a photo with the Argentine idol. The boy, who operated heart felt touch the sky with his hands to be with Messi.


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Comments Posted By BhaktaRoyBaba
Displaying 1 To 1 Of 1 Comments
Astronomical Models of Lunar Position
«« Back To Stats Page
Where you say, "Such a model cannot be based only on sastra. To be scientific and convincing it must have explanatory and predictive power in the physical world. It should be based upon Vedic literatures, logical hypothesis, empirical observation, and established historical precedents."
I must admit I was taken aback by part of this statement, and cannot agree with "logical hypothesis, empirical observation, and established historical precedents."
However the part where you say, "To be scientific and convincing it must have explanatory and predictive power in the physical world."
I can see that viewpoint as valid in the sense that if the knowledge revealed in the sastras are indeed science than they should be able to have an explanatory model.
As to much of the rest of the article it seems you argue more from the point that modern mainstream science has more answers than the sastras. That might be the view of many. But it is not the view of all the scientists nor all learned people.Nor is it the view expressed in Srila Prabhupada's books.
Amazing things things are not easily accepted by the masses.Cutting edge breakthroughs are often rejected.
The sastras describe things like the same concept as special relativity, atomic particles, string theory, the fact that space and time are curved, matter outside the universe, anti-matter and so many things.Prior to this century most of these would have been scoffed at by many.But now they don't seem so far fetched do they? A nice example in one of the purports Prabhupada says, "The atom is the minute subtle form of eternal time." (Śrīmad Bhāgavatam 3.11.1).Science has not yet caught up to that single statement.Except maybe Dr. Albert Einstein.
It is no wonder why learned men such as Dr. Einstein studied the Vedas, Bhagavad-Gita.He was one of the top scientists, so what need would he have of sastra?Well maybe you have heard, "the more one knows, the more questions are revealed."
Dr. Einstein's formulas may imply that space-time is so curved that the current models of the earth and solar system need to be revised.
I think all can respect your article and opinions expressed as at least wondering how things like the Vedic planetary models can be done practically.
But cutting-edge models may appear impractical.For they are not just for men of today but the future.In 1,000 years who knows, maybe science will have caught up?
» Posted By BhaktaRoyBaba On Nov 5, 2010 @ 11:16 pm
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Ultrasound and Self-Healing Hydrogels Noninvasively Deliver Targeted Chemotherapy
By Medimaging International staff writers
Posted on 08 Jul 2014
Image: Harvard researchers have shown how ultrasound can temporarily disrupt an alginate hydrogel, which is held together by calcium ions (black dots) that are bound to acid chains (yellow). The gel self-heals when the ultrasound stops (Photo courtesy of the Wyss Institute and Harvard SEAS).
Image: Fluorescence micrographs show red-colored breast cancer cells that were exposed to three different treatments. The use of ultrasound to trigger periodic bursts of higher drug doses (right) was most effective in killing the cancer cells (Photo courtesy of the Wyss Institute and Harvard SEAS).
Modern drug-delivery systems used to administer chemotherapy to cancer patients typically release a constant dose of the drug over time. But a new study challenges this gradual approach and offers a unique way to locally deliver the drugs "on demand."
The study's findings were reported online ahead of print June 24, 2014, in the journal
Proceedings of the National Academy of Sciences of the United States of America (PNAS).
Led by David J. Mooney, PhD, a core faculty member at Harvard University's Wyss Institute for Biologically Inspired Engineering and a professor of bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS; Cambridge, MA, USA), the scientists packed a biocompatible hydrogel with a chemotherapy drug and used ultrasound to trigger the gel to release the agent. Similar to many other injectable gels that have been employed for drug delivery for decades, this one slowly releases a low level of the agent by diffusion over time. To temporarily increase doses of drug, scientists had earlier applied ultrasound--but that strategy was a one-shot job as the ultrasound was used to destroy those gels. However, this gel was different.
The investigators used ultrasound to temporarily disrupt the gel such that it released short, high-dose bursts of the drug--similar to opening up a floodgate. But when they stopped the ultrasound, the hydrogels self-healed. By closing back up, they were ready to go for the next "on demand" drug burst—providing an innovative way to administer drugs with a far greater level of control than possible before. Furthermore, the investigators also demonstrated in lab cultures and in mice with breast cancer tumors that the pulsed, ultrasound-triggered hydrogel approach to drug delivery was more effective at blocking the growth of tumor cells than conventional, sustained-release drug therapy.
"Our approach counters the whole idea of sustained drug release, and offers a double whammy," said Prof. Mooney. "We have shown that we can use the hydrogels repeatedly and turn the drug pulses on and off at will, and that the drug bursts in concert with the baseline low-level drug delivery seems to be particularly effective in killing cancer cells."
The advance holds potential implications for improved cancer treatment and other therapies requiring drugs to be delivered at the right place and the right time—from post-surgery pain medications to protein-based drugs that require daily injections. It requires an initial injection of the hydrogel, but the approach could be a much less traumatic, minimally invasive and more effective method of drug delivery overall, according to Prof. Mooney said.
"We want to give clinicians the ability to deliver drugs as locally as possible combined with the flexibility to temporally control the dose," said co-lead author Nathanial Huebsch, PhD, who was a Harvard SEAS graduate student in the Harvard-Massachusetts Institute of Technology (MIT; Cambridge, MA, USA) division of health sciences and technology at the time of the research. For example, many cancer patients require a regular dose of pain killers, but unpredictable pain attacks require them to take much larger doses over a short time.
Key to the success of the project was devising a hydrogel that self-heals is choosing the right kind of hydrogel with the right kind of drug—and applying the right intensity of ultrasound. "We were able to trigger our system with a level of ultrasound that was much lower than high-intensity focused ultrasound that is used clinically to heat and destroy tumors," said co-lead author Cathal Kearney, PhD, who was a postdoctoral fellow at SEAS at the time of the study. "The careful selection of materials and properties make it a reversible process," Dr. Kearney said.
The scientists performed most of their research for this study with a gel composed of alginate, a natural polysaccharide from algae that is held together with calcium ions. In a series of laboratory tests they found that with the correct level of ultrasound waves, the bonds break up and enable the gel to release its drug payload, but as long as the gel in in the presence of more calcium, the bonds reform and the gels self-heal.
Once the researchers figured out that the gel would self-heal, they evaluated a drug that they believed it would hold well—in this instance, a chemotherapy drug called mitoxantrone, which is frequently used to treat breast cancer. In fact, the ultrasound triggered the gel to release the blue-colored drug, as indicated by the newly blue color of the surrounding medium. Only one ultrasound dose was effective, and the gel reformed after it was disrupted, making multiple cycles possible.
Next, they tested the treatment on mice that had human breast cancer tumors implanted in their bodies. They injected the drug-laden gel close to the tumors, and over the course of six months the mice that received a low-level sustained release of the drug with a daily concentrated pulse of ultrasound (only 2.5 minutes) fared significantly better than mice treated the same but without ultrasound. In contrast to the other groups, the tumors in the ultrasound-treated mice did not grow substantially and, moreover, the mice survived for an additional 80 days.
"These results demonstrate how applying novel engineering approaches and programmable nanomaterials can create entirely new solutions to critical medical problems," said Wyss Institute rounding director Don Ingber, MD, PhD, who is also a professor of vascular biology at Harvard Medical School and Boston Children's Hospital (Boston, MA, USA), and professor of bioengineering at Harvard SEAS. "Dave's work shows that these new responsive hydrogels that remodel reversibly when exposed to ultrasound energy at the nanoscale not only provide a new way to administer drugs on demand, they also produce better responses to therapy even in a disease as difficult to treat as cancer."
This development to use simple ultrasound pulses and readily available hydrogels in a new way comes after Prof. Mooney's work using low-power lasers to stimulate stem cells to regenerate the material that comprises teeth. The scientists also demonstrated that the gel can release other kinds of cargo as well, including proteins, which lays the foundation for potentially using these hydrogels for tissue regeneration, and condensed plasmid DNA, suggesting their potential use in gene therapy.
The scientists next plan to examine these other potential applications, as well as the possibility of releasing two different drugs independently from the same hydrogel, according to Prof. Mooney.
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EVE Online Incarna goes live
EVE Online players, rejoice! The day you've been waiting for is finally here. Today marks the release of EVE Online's much-anticipated Incarna expansion. The most notable addition with this update is undoubtedly the new ability for players to finally exit their spaceships and explore the...
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|Photo by Robin May
|"The Governor does not determine learning standards, nor does he create tests" — state Superintendent of Education John White
As expected, Gov. Bobby Jindal took steps Wednesday to pull Louisiana from Common Core testing, but Superintendent of Education John White says the new academic standards will remain in place for the upcoming school year.
Jindal issued a letter to the Partnership for Assessment of Readiness for College and Careers, notifying the consortium of the state's withdrawal; he also issued an executive order forbidding the state Department of Education from using the testing standards, while also freezing funding for the tests.
In a statement released Wednesday, Jindal takes a line straight from the mouths of Louisiana's Tea Party, arguing:
[P]roponents weren't up front about federal involvement in PARCC and Common Core. Now that we understand the federal overreach involved, we need to slow down and make the right decision. Some Common Core proponents suggest that we cannot have high standards without Common Core. That is a false statement. We need a Louisiana test that ensures children are performing at high levels so they can compete not only around the country, but around the world. We can certainly have high standards without giving up control of Louisiana's education system to the federal government.
On the other side of the argument, White says the Department of Education and the Board of Elementary and Secondary Education remain committed to the new academic standards.
Contrary to Jindal's attempt to scrap Common Core, White says the DOE will move forward with its implementation.
In a statement issued Wednesday, White says:
State and federal law have long required that Louisiana measure literacy and math performance through standards and annual tests. By using test forms and questions that make results comparable among states, we are following the Legislature's mandate that we not only measure but also compete.
The Governor is sending a letter to the National Governors Association and the Common Core State Standards withdrawing Louisiana ... The Governor does not have this authority ... The Governor does not determine learning standards, nor does he create tests.
White's statement was no doubt a ballsy move, and while Jindal's attempt to pull Louisiana from Common Core is legally iffy, the real question now is how long it will be before Louisiana is looking for a new education super.
The countdown begins.
NOV 21 Bobby Jindal is headed to Iowa again, the Des Moines Register reports here. The paper outlines what's going on with Bobby's non-campaign for president, and there's a lot of stuff here -- too bad none of it sounds like somebody running Louisiana. Hey, wasn't that the job he wanted?
NOV 21 The end of the term has come for the grand jury investigating a lucrative Medicaid contract and a former state health official's ties to the company that won it, the Advocate reports here, but that doesn't mean the investigation into this stinkiness is over. There are still some things to look into, the lead prosecutor says.
NOV 21 With the passage of two amendments to Louisiana's much-amended constitution (it has been amended almost 200 times now) higher education has an even bigger target on its collective back, columnist Jim Beam opines in this post. Higher ed used to share the spotlight with health care, but that has changed, he says.
NOV 21 Here's a weird one: The Louisiana Cannabis Industry Association has endorsed Bill Cassidy for the U.S. Senate. Apparently, Mary Landrieu said she wouldn't consider support of medical marijuana but Cassidy said he would, WWL reports here.
NOV 21 Solange Knowles, possibly best-known for assaulting her brother-in-law in an elevator while wearing an ugly dress after the Met Ball, got married in the Marigny Opera House this past weekend, the New York Times reports here. Knowles, who has a house in the Faubourg Marigny district and owns a boutique in the Quarter, married Alan Ferguson.
NOV 21 This post on the Fuel Fix blog outlines a $1.4 billion move announced this week by the Apache Corp. that includes the sale of assets in south Louisiana. The company's interests in more than 90,000 acres in south Louisiana are some of the assets being sold, the post reports.
NOV 21 One (possible) positive from Hurricane Katrina is a comprehensive zoning ordinance for New Orleans. Nine years later, we're getting closer to that being finalized, but the current version has some problems. Here's the latest in a series of posts on The Lens in which residents give their views of the draft; this one is more amusing than most.
NOV 21 The new NOLA smoking ordinance is going to harsh your (nicotine) buzz, man. This post on Gambit outlines the high (or low, as the case may be) points: it includes electronic cigarettes and hookahs in its bans; eliminates smoking within 25 feet of any building's public entrance and in any public space - or near any public space - operated by the city.
NOV 20 Here's an interesting article in the New York Times. The authors have picked one dish to represent each state in a Thanksgiving meal. Louisiana's dish? Shrimp stuffed mirlitons.
NOV 20 Politico reports here that Bobby Jindal won't be kept out of the presidential race by anyone else's candidacy. (If he's running, which he's not, 'cause he's not done prayin' on it) So he's not interested in who is running, or what the polls say, or how much money he's got? K.
NOV 20 NOLA Defender's Tiny Daiquiri has a little fun with Bobby Jindal's Meet the Press appearance in this post. Bobby is still prayin' on whether or not he'll run for the job he's been running for over the past three years, Tiny says.


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It Is IMPERATIVE To Know OF Sex Offenders Living In Your Community!
- Each year there are as many as 350,000 sex crimes are reported.
- Approximately 60,000 - 70,000 sex crimes are committed against minor under 18 years of age
- Over 550,000 convicted sex offenders were released, and are residing within our cities, nationwide.
- The residency status of over 100,000 convicted sex offenders, are unknown to (authorities|law enforcement officials|local law enforcement}.
- Staying aware of the risks that are present in your area, is the best way to keep your loved ones protected.
Your Sex Offender Report Gives You:
- Recent housing location records
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- Latest photos of sex predators
- Details of the sexual offense that was committed.
- Details and date offender was apprehended
Make your FREE search now. Find out how many of Seattle, Washington Offenders are living near you home.


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Barca agrees with Messi
06 May 2014 [09:15] -
This week could see Barcelona and Leo Messi sign the player's new contract, with the two sides all set to hold one last meeting to dot the i's and cross the t's. The Catalan club have been waiting for Jorge Messi to return from Argentina to schedule the meeting.
With no other commitments on the horizon, the player's father and Josep Maria Bartomeu will sign a deal which will see Leo Messi's wages significantly increased, making him the highest paid footballer in the world. The striker currently receives a net sum of 16 million including bonuses.
With this move Barcelona will drastically increase the player's pay packet. After a long tug of war, the basics of the deal have now been thrashed out. The biggest stumbling block for both sides was the amount the star should receive in bonuses every year. This has now been overcome and the deal could be made public sometime this week.
It is worth bearing in mind that Barcelona do not want the issue to drag on and that renewing the Argentine's contract is the best way to put paid to the rumours about a possible departure
There is also a possibility the agreement may run for one further season. Messi's current contract expires on 30th June 2018.
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Wharton with four offers
Christian County (KY.) standout Devon Wharton is one of the top defenders in the state. The junior…
Do offer lists predict future success? That and the two decommitments, a new commitment and other notes from the Midwest.Read More
Every week, Fantasy Football Expert Rusty Reeves predicts a heaping handful of players who will decline in the coming weeks. They should be downgraded at least one tier. Chicago Bears QB Jay Cutler …Read More
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Look of the Day: Royal in Blue
by Fashion 20 Reactions 0 Shares Print
Cobalt blue is everywhere these days and I don't mind one bit. Sinplicit looks smashing and royal in blue. I love the contrast between the cropped white peacoat and the blue mini dress - it's very Jil Sander.
Here's what she's wearing:
- Mini Dress: Forever 21
- Cropped Coat: Banana Republic
- Leggings: Banana Republic
- Wedges: Vintage
Congrats to Sinplicit!
Everyone else, submit your looks and vote on your favorite ones today and I just might feature you on FabSugar! If you live overseas and have a fab outfit to share, join the Overseas Fashionistas Group and to submit a Look in this group learn how to post a blog.
Read More CobaltLook Of The Day
Look of the Day
celebritytrunk 7 years
OMG, love the cobalt blue tunic and the jacket is the PERFECT compliment. I can't wait to try and replicate this look. Very chic and mod!
sinplicit 7 years
thanks guys! the wedges unfortch is falling apart. i have to wear them sparingly.
JKe895 7 years
You look awesome!!!
JKe895 7 years
You look awesome!!!
fashionstar 7 years
I really like every piece in this outfit, especially the jacket and shoes, the only thing is that I know that all the colors go well together at first I didn't care for the boldness of the black with the cobalt and white. But the more I look at it the more I love it. :)
nati 7 years
love it!
nati 7 years
love it!
glam-sugar 7 years
Nice look
glam-sugar 7 years
Nice look
Mme-Hart 7 years
Mme-Hart 7 years
roxxiluv0x 7 years
amazing outfit! i wish the wedges werent vintage... then i could buy them. they are so cute
The-New-Black 7 years
love the coat!
The-New-Black 7 years
love the coat!
sandra-werner 7 years
I have NO IDEA how I missed this outfit in The Lookbook! It is perfect!!! :)
Lala77 7 years
cute :)
Lala77 7 years
cute :)
imahoopie 7 years
I like that she didn't wear black shoes with this outfit, as it would have ruined the look.
Daylyn 7 years
Very cute! :)
Daylyn 7 years
Very cute! :)
Link Love
- The designers shared what they're coveting this holiday season — Who What Wear
- There's an art to waiting in line on Black Friday — HuffPost Style
- One day, Victoria Beckham walked into Claire's . . . — InStyle
- John Galliano will present a very important award to Anna Wintour — The Cut
- We're dreaming about these Comme des Garcons sneakers — Style.com
- Eva Chen actually fainted when she saw Karl Lagerfeld — Lucky
- Burberry's Pre-Fall collection is chock-full of coats — Fashionista
- Lululemon's limited-edition collection is sparkling — literally — Racked
- Forget tights. Forget knee-highs. It's all about ankle socks — The Fashion Spot


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Wednesday, 12 Feb 2014 10:24 PM
The White House says President Barack Obama is nominating Vicki Kennedy to the board of governors for the U.S. Postal Service.
Kennedy is the widow of former Sen. Ted Kennedy, who died in 2009. The Massachusetts Democrat was a prominent supporter of Obama's first presidential campaign.
Vicki Kennedy is a lawyer and co-founded the Edward M. Kennedy Institute for the United States Senate. She's also on the board of trustees for the Kennedy Center.
Kennedy's nomination must be confirmed by the Senate. The board of governors chooses the postmaster general and controls the postal service's spending, planning and policies.
© Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Saturday, 22 Nov 2014 19:56 PM
A Missouri state senator and gun-control advocate who has protested police actions in Ferguson surrounding the Michael B . . .
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Two men suspected of buying explosives they planned to detonate during protests in Ferguson, Missouri, once a grand jury . . .
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The grand jury deciding whether to in . . .
Well...,it looks like we can anticipate the Ferguson Grand Jury decision this...
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Global warming biggest hoax of mankind,...
Not a smidgeon of evidence . 30,000 emails from lois alone ion that time period...
1. Ok we know the problem, now what is Congress going to DO about it? Stop...
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Local Rooms: The Alexis Hotel
Posted Jan 24, 2012, 4:00am
The Hotel The Globe building was built about a decade after the Great Seattle Fire of 1889 wrought massive damage downtown. In 1982 it was renovated and reopened as the Alexis Hotel, where you can still see 19th-century storefronts in the parking garage. The boutique property pushes high culture: pieces from the Seattle Art Museum in the lobby, wine tastings every night, and books all over the place.
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2012 CEO pay report
|| Print |
|Articles - October 2012
|Monday, September 24, 2012
Page 2 of 3
Median pay for all 20 Oregon CEOs has remained less than a third of the S&P 500 CEO pay.
That median pay rose from $2.1 million in 2007 to $3.0 million in 2011. Equilar produces an annual S&P 500 CEO Pay Study, which shows that prior to the recession in 2007, median S&P 500 CEO pay was approximately $8.7 million. It fell the next two years; then, as stock markets recovered, it roared back to $9.6 million in 2011. Nike, Precision Castparts and FLIR are currently the only Oregon companies included in the S&P 500 index.
Nike CEO Mark Parker's total pay was more than a third of the $103 million paid to our CEO group.
Parker earned more than $35 million for the year ended in May 2012. Two-thirds of Parker's pay was stock awards, which could rise or fall in value by the time he can exercise them. He received no bonus and his salary was only $1.6 million.
Looking at Nike's performance, net income only declined once, in 2009, and was at an all-time high of $2.2 billion for 2012. Nike's stock price is also flying high, elevating the grant-date value of Parker's equity.
CEO pay and company performance seesawed wildly during the past five years' mostly in synch' but sometimes not.
Nationally, S&P 500 CEOs saw their median compensation decline in 2009, then rise the next two years, roughly in line with company net income, which shifted higher and lower than pay.
Likewise, average CEO pay for the top 19 companies in Oregon (excluding Nike) fell in 2009, then rose the next two years, increasing an average of 11% per year. Company net income followed the same — more extreme — pattern but only rose an average of 2% per year.
Individual companies, though, often strayed from company earnings. Parker's percentage change in pay rose three times as high as net income in 2010, fell in 2011 when earnings continued to grow, then shot up 219% in 2012, while net income grew just 4%.
As a share of pay' salary has been in retreat for decades.
Don Lindner, executive compensation practice leader for WorldatWork, a nonprofit association focused on compensation education, says that base pay used to comprise about 50% to 60% of CEO compensation until the 1980s.
Then came IRS Section 162(m) in 1992, stipulating that corporations could deduct no more than $1 million of executives' non-performance pay. To avoid tax liability, annual bonuses rose dramatically, says Lindner, and mega-grants of stock and options were invented, raising the prominence of equity awards. Regulators effectively had placed a limit on salary, but the unintended consequence was to rapidly increase total compensation, albeit in a leveraged form.
Among Oregon's top 20 CEOs, average salary grew 5% per year since 2007, but as a share of total compensation it declined from 22% in 2007 to 14% in 2011. Salary accounted for just 10% of the S&P 500 CEOs' 2011 pay. This decline of salary's share is exacerbated by rising equity awards — much riskier and less liquid than cash.
"To replace base pay, which is a sure thing, with at-risk pay like options, you have to give them a whole bunch more [stock and options], because they're worth less," says Lindner.
Two Sides of the CoinContributed Blogs
Friday, September 26, 2014
This post focuses on the recent release of the new Apple iPhone as well as Alibaba's IPO, the largest U.S. IPO in history.
Read more...
Constant ContactOctober 2014
Thursday, September 25, 2014
To prevent burnout, companies are banning email and after-hours communications. But is the 24-hour workday here to stay?
Read more...
The Rail BaronOctober 2014
Thursday, September 25, 2014
Oil is gushing out of the U.S. and Canada, and much of it is coming from places that don't have pipeline infrastructure. So it's being shipped by rail.
Read more...
Political CloutNovember/December 2014
Wednesday, October 22, 2014
Businesses spend billions of dollars each year trying to influence political decision makers by piling money into campaigns.
Read more...
Election SeasonNovember/December 2014
Wednesday, October 22, 2014
We didn't intend this issue to have an election season theme. But politics has a way of seeping into the cracks and fissures.
Read more...
100 Best Nonprofits announcedNews
Thursday, October 02, 2014
Oregon Business magazine has named the sixth annual 100 Best Nonprofits to Work for in Oregon.
Read more...
Semiconductor purgatoryNews
Monday, October 06, 2014
Intel's manufacturing way station; Merkley's attack dog; Diamond Foods gets into the innovation business.
Read more...
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|Dollar hits highest point against Yen since 2007
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Is your business ready to join us in the call for action? This opening panel includes Oregon businesses who will discuss why they signed the Oregon Climate Declaration, the investments they are making to reduce carbon emissions, and how their actions are affecting their companies.
Get ready for two days of special events produced with the EPA, Portland Timbers and ISOS before and after the GoGreen Conference on October 16.
Plenty of employers seem "dazed and confused" after the recent vote to legalize marijuana. In light of Measure 91 passing, what are some issues for private-sector Oregon employers to consider?
Rotary's Oregon Ethics in Business aims to raise consciousness about business ethics by honoring exceptional companies.
Barran Liebman's annual employment law seminar is an industry classic.
Is my drug-free workplace policy up in smoke?
More than 400 "Change Makers" will gather to invest in a socially sustainable community.
Sussman Shank LLP is pleased to announce that Dallas G. Thomsen and Victor J. Roehm have become partners of the firm.


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Hollow-fiber permeability apparatus
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A hollow-fiber permeability apparatus includes:a housing; a bundle of permeable-wall hollow fibers disposed in the housing; inlet means for supplying a first fluid into the spaces between the fibers; outlet means for withdrawing the first fluid from the housing, the first fluid being led through at least one of the inlet and outlet means in a lamelliform flow toward the bundle, whereby the first fluid can uniformly flow through the whole bundle; and means for flowing a second fluid inside the fibers such that materials selectively permeate through the walls of the fibers.
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Designs for Eliana
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Wind River Integrates Virtualization Technology into Next-Generation RTOS for Internet of Things
ALAMEDA, Calif.-- August 18, 2014 -- Wind River®, a world leader in delivering software for intelligent connected systems, has introduced a virtualization profile for the next generation version of its market-leading VxWorks® real-time operating system (RTOS). Based on proven Wind River virtualization technology, Virtualization Profile for VxWorks extends the scalability capabilities of the VxWorks 7 Core Platform by integrating a real-time embedded, Type 1 hypervisor into the core of the RTOS.
Through embedded virtualization, Virtualization Profile allows VxWorks customers to consolidate multiple workloads on a single processor. It provides robust, safe and secure partitioning across all market segments, from automation control to medical scanners to avionics control systems -- critical in today's era of the Internet of Things (IoT). OS-agnostic, the profile allows combinations of VxWorks, Linux, Windows® and other operating systems to share the memory and cores of a multi-core processor or system-on-chip (SoC).
"VxWorks with integrated virtualization allows customers to address IoT device challenges, where connectivity, scalability, security, and future-proofing are required," said Dinyar Dastoor, vice president of product management at Wind River. "It delivers the key benefits that will give our customers a competitive edge in consolidation, flexibility, safety, and security, as well as CAPEX and OPEX savings, and significant reduction in development time for end devices. We see a strong need for these capabilities across all market segments, but with an emphasis where connectivity is now requisite, such as in industrial, medical, aerospace and defense."
Recognized as the industry-leading RTOS, VxWorks has been re-architected with a highly modular approach leading to the separation of the VxWorks core operating system from packages such as the file system or networking stack. As a result, individual applications can now be updated at any time without requiring a rework or retest of the entire system, increasing scalability and the ability to quickly adjust to market changes.
Wind River will be hosting a webcast, titled, "Meeting Today's IoT Device Challenges with Virtualization and Consolidation," this Wednesday, August 20. For more information and to register for the webcast, visit http://bit.ly/Y1kyvf.
More information about Virtualization Profile for VxWorks is available at http://tinyurl.com/VxWorksVirtualization. And to learn more about how Wind River is addressing the opportunities and challenges created by the Internet of Things, visit http://tinyurl.com/iotsite.
About Wind River
Wind River, a wholly owned subsidiary of Intel® Corporation, is a world leader in delivering software for intelligent connected systems. The company has been pioneering computing inside embedded devices since 1981, and its technology is found in nearly 2 billion products. Wind River offers the industry's most comprehensive embedded software portfolio supported by world-class global professional services and support, and a broad partner ecosystem. Wind River delivers the technology and expertise that enables the innovation and deployment of safe, secure, and reliable intelligent systems. To learn more, visit Wind River at www.windriver.com.
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