text:
Merkel against unilaterally recognizing Palestine as a state
Report: Abbas accuses Israel of using wild boars against Palestinians
Jewish youths hurt in brawl with Arabs in east Jerusalem
Riots break out in various areas of West Bank
Hamas denies knowledge of Liberman plot, but says leaders of 'occuaption' are legitimate targets
Israeli official: Erdogan rhetoric befits Tehran or Damascus, not a NATO capital
Netanyahu proposes his own version of 'Jewish state bill'
Israel's ambassador to return to Sweden on symbolic Nov. 29th date
Netanyahu: We have nothing against east Jerusalem residents, but we must protect our citizens
Pro-public health advocates battle against private-medicine lobbying and ad campaign
Doctors, nurses more than twice as likely to get flu shots than general population
Cheapen gluten-free food for celiac patients, panel says
Project to improve nutrition loses funds
'Leviathan gas reservoir to begin flowing by early 2018'
New kid's Israeli archaeology game launched for iPhone
Green Knesset advances as MKs replace paper with iPads
Zion Tech: Our Israeli start-up of the week aims to revolutionize therapy access
James Blunt is coming to get 'high' in Tel Aviv
Staging music
Grapevine: Farewell to an articulate advocate for Israel
Theater Review: The Tempest
Yellow-and-blue survives scare to beat Limoges
Beersheba with an opportunity to go top
Back-on-track Maccabi Tel Aviv takes on Limoges in Euroleague
Hapoel Jerusalem facing early Eurocup exit
HRW: Israel's demolition of Palestinian terrorists' homes is 'war crime'
Jerusalem mayor: We cannot discriminate against Arabs
English soccer club owner faces racism probe for saying Jews 'chase money'
Lawmaker in Antwerp calls on Belgian government to fund security for Jews
German survey: Spike in anti-Semitism after Gaza war
WATCH: How do American college students react to ISIS, Israeli flags?
Picking up the pieces of a lost culture
More reconstruction materials slated to enter Gaza next week
Jordanian PM reportedly sends condolence letter to families of Jerusalem synagogue terrorists
Yemen minister dedicates award to country's Jews
ISIS releases new video with Cantile
IAEA to discuss Iranian offer to allow 'managed access' to site
Into the Fray: The Arabs' war against the Jews and what must be done
My Word: A personal response to terrorism
An open society
November 21, 2014: Expel 'shahids'
No Holds Barred: The ferocious battle for Israel at New York University
Wishful doing
Cinema of reconciliation
On the volcano's edge
Knowledge, power and abuse
Q&A with a Colombian lone soldier
European Press: Dividing line
Veterans: Keeping an ear out for change
Book Review: Written from his heart
This Week in Jerusalem
Who is your God?
Grapevine: Amazing place
A voice from India
Happily Eva After: When the going gets tough...
Grapevine: Reclaiming our heritage
Upscale dining in Neveh Tzedek
A war for the soul of Israel's Arab community
Iran and the West – how big a gap?
Iranian nukes and 'Palestine' - mutually reinforcing perils for Israel
Islamic State – APEC a fizzer - G20 promises no better
A song for Cheshvan: 'The Eucalyptus Grove'
דְיוֹקְנְאוֹת תַרְבּוּת
מָה הַסִיפּוּר?
הָאַרְכִיוֹן שֶל רוֹמַן וִישְנִיָאק
Har Nof in flames
Meet the Ambassador: No longer a conference diplomat
'Post' leads the way with new podcast
Grapevine: The highest accolade of all
The secret of Jewish survival
Frontlines Podcast: Jerusalem's 'lone wolves'
Tempête au sein de la coalition
Crise de confiance
Qui prendra la relève de Mahmoud Abbas ?
Arafat, Abbas, même combat ?
Daniel Oren, maestro d'Israël, d'Italie et d'ailleurs !
Nos plus belles années ?
De Berlin à New York, 1920-1975
Le pogrome de Constantine
Le pot de chocolat liégeois par qui le scandale arrive
Le dernier kibboutz
La course aux étoiles
Les mordus du français
On n'invite pas un pyromane à éteindre un incendie
Tuer l'EI dans l'œuf
Le mont du Temple et la guerre sainte de l'islam
Les attentats du lundi 10 novembre vus par la presse française
L'Europe, nouvelle alliée d'Abbas ?
Ces enseignants-éclaireurs
Pope Francis condemns Palestinian violence
Last Christian shop-owners in Old City: 'Tourists afraid of the politics'
Kurdish refugees struggle to survive as they outrun Assad's army and ISIS
Discover Ramla from a Christian persepective
Pastor who died in crash mourned in Israel
KKL Belgium Donates Portable Bomb Shelter to Kiryat Gat
KKL-JNF Awards 2014 Blumberg Prize
Exploring the Ilanot Botanical Garden and the Vickar Observation Point
Cornerstone Laid for Sports Rehab Park at Meir Hospital
Mexican Politician and Business Leader Miguel Aleman Velasco Visits KKL-JNF in Jerusalem
International Conference in Sde Boker: Combating Desertification Together
Rehabilitation of the Lower Jordan: Bringing the River Back to Life
Central America Celebrates Independence at the Rabin Center
In his Footsteps: Heritage Excursions in Memory of Yitzhak Rabin
Cleanup Day Activities in Central Israel
International Cleanup Day: Cleaning Together in Northern Israel
KKL-JNF's Eyes in the Forest - The Horshim Forest Green Patrol
Israel Today and Tomorrow: KKL France Mission Visits Israel
Start-up Israel: KKL Italy November Mission Learns about Israel's Past and Future
KKL-JNF and Desert Agriculture Latin American Diplomats visit the Negev
A Successful Annual Fundraising Event for KKL Milan
Living Green in Israel: the Contest and the Winners
Addressing Climate Change Conference
Nurturing the Foresters of the Future
Saving the Sabras
11.22.2014 | 29 Heshvan, 5775
Into the Fray: The Arabs' war against the Jews and what must be done
My Word: A personal response to terrorism
An open society
November 21, 2014: Expel 'shahids'
No Holds Barred: The ferocious battle for Israel at New York University
Charley's game
Know Comment: The essentiality of anger
Yael's Corner: Our answer to darkness
'Battle for Jerusalem' is personal
Toldot: The ability to say 'I made a mistake'
Another Tact: The perils of peace
Is this really an intifada?
06/28/2012 21:09
Sinai Today: Message of strength and faith
Mourning the Toulouse shootings 370.
(photo credit:REUTERS)
Rebbetzin Eva Sandler of Toulouse, France, recently spoke at Sinai Indaba, South
Africa's annual national Torah convention, which brings together more than 4,500
Jews.A modern-day Jewish heroine, she spoke with remarkable composure
and dignity about her husband, Rabbi Yonatan Sandler, and their sons Aryeh and
Gavriel, brutally murdered by an Islamic terrorist on March 25, 2012.Eva
Sandler's fortitude in the face of horror was truly moving; her calm and brave
presence in Johannesburg and Cape Town brought a message of strength and faith
to us all. Although she spoke sentence by sentence through a translator, the
language and cultural barriers – which by any rational analysis should have
separated us into different worlds – seemed to dissolve; there was a strong
sense of shared Jewish fate.As Rebbetzin Sandler recounted the details
of that terrible day, we all felt that Toulouse could have been, G-d forbid,
Johannesburg or Cape Town, New York or London, Jerusalem or Tel Aviv. There is a
shared Jewish fate which binds all Jews, in defiance of the natural laws of
history.Rav Yosef Dov Soloveitchik, in his foundational essay Kol dodi
dofek ("The voice of my beloved knocking"), identified two distinct covenants
between G-d and the Jewish people: the "covenant of fate" and the "covenant of
destiny."G-d entered into the covenant of fate with us whilst we were
still subject to Egyptian slavery, when He said, "I will take you to me to be a
nation." Through this covenant we became a separate people with a shared and
supernatural fate for all times, and from which there is no escape.In
the past 70 years, for example, we have seen the irresistible power of this
covenantal shared fate as Nazi Germany sought to annihilate assimilated and
religious Jews alike. And today the covenant of fate binds all Jews, willingly
or unwillingly, to the State of Israel and to the events and pressures that
accompany anything to do with it. Every Jewish community around the world has
been thrust to the front lines facing the anti-Israel onslaught, which in its
milder form can mean being denigrated and isolated and in its most virulent form
poses a serious threat to life and limb as attested to by Eva Sandler's
tragedy.Rav Soloveitchik explains that the covenant of fate binds us and
imposes on us a moral responsibility toward one another's welfare. Every Jew
must stand in solidarity with, and help, support and protect every Jew
unconditionally, irrespective of political affiliation or religious observance
or any other criterion. The allencompassing covenant of fate connects us all,
giving expression to the very concept of Jewish peoplehood and unity.The
covenant of destiny goes beyond the covenant of fate which simply binds us as a
nation through force of external circumstances.The covenant of destiny,
known also as "the covenant of Sinai" because it was entered into at Mount Sinai
when G-d gave us the Torah, is about our shared values, moral vision and the
Divine mission of the Jewish people. It is comprised of the Torah's principles
and values and calls us to a higher destiny, one which transcends mere survival.
It is about why we want to survive, and what our purpose and moral calling is.
It gives us our mission, articulating the raison d'être of the Jewish
people.In her courageous speeches in Johannesburg and Cape Town,
Rebbetzin Sandler epitomized both the covenant of fate and the covenant of
destiny. She spoke of her life mission – to continue the work that she and her
husband had been doing prior to the attack. They were teachers of Torah and
leaders of their community. She spoke about their decision to return to France,
after many years of yeshiva study in Israel, to give back to their community of
birth and where they were raised and educated.She spoke of her
determination and commitment now to continue to promote Torah values in the
world so that the terrorists who attack these values will not be granted
victory.It is this mission which brought her to South Africa; as she
said, before the tragedy she could never have imagined that one day she would be
in South Africa. But she accepted my invitation to Sinai Indaba, a convention
dedicated to the covenant of destiny, to continue her mission of teaching Torah
values and bringing a message of faith and loyalty to G-d.Rav
Soloveitchik says further that the covenant of destiny redeems the covenant of
fate from the latter's potential victimhood.In the context of the
covenant of fate we become subjected to the overpowering forces of history; we
play a reactive role, with no choice but to respond due to force of
circumstances, trying simply to survive. The covenant of destiny, however, is
embraced freely and chosen, as it was first entered into at Mount Sinai. The
covenant of destiny gives us a sense of purpose, a sense of who we are and why
we are here, and what our moral calling is in this world. It gives Divine
meaning, context and imperative to the role of the Jewish people in history, and
indeed to our lives as individuals.It was powerful and moving to witness
these ideas of Rav Soloveitchik embodied in Eva Sandler, who transcended
victimhood to become a modern-day heroine. At Sinai Indaba she spoke of her pain
and of her moral mission to spread the light of Torah and faith in the world,
calling on us to join her. She has moved beyond succumbing to despair from
tragic events to rising to a moral vision and calling, redeeming the covenant of
fate through the covenant of destiny.If we regard Jewish peoplehood as
solely about physical survival and responding to external events and threats,
then we lose our sense of purpose and mission which come from our Torah, given
at Sinai. The covenant of fate is unconditional and all-embracing, while the
covenant of destiny, rooted in Torah and mitzvot, proclaims a clear and specific
moral vision for the Jewish people.These two covenants are the framework
for Jewish unity and peoplehood. The covenant of fate enjoins us to embrace and
care for every Jew, no matter how different he or she is, to stand in solidarity
with Jews around the world and to defend the State of Israel. And the covenant
of destiny calls upon us to embrace our shared moral vision and fulfill our
Divine mission.The writer is chief rabbi of South Africa.
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text:
Custom Lettering Graffiti Girl
Details about Custom Lettering Graffiti Girl
This custom wall decals comes in 2 pieces easy to install and you can choose up to 15 letters for the text of this wall decal.
- In the 59"x65" decals, the girl is 27"x59"
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- In the 33"x36" decals, the girl is 15"x33"
- In the 22"x24" decals, the girl is 10"x22"
Graffiti Girl custom lettering is a bi-color decal: you can choose the color of the text and the color of the girl separately. If you order custom lettering graffiti girl in reverse, only the design will be reversed. Your lettering will be as you wrote in the text box.
Decal color shown in the picture: Purple & Black
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subset: commoncrawl


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text:
Canstar Community News - ONLINE EDITION
Everyone knows a Jim...
I wasn't 20 steps into our downtown library, when a man called me by name.
"Stephanie! Do you remember me?"
He was a big man. He had long, curly hair that almost covered his eyes. He had a bushy, unkempt beard. I was certain I'd never met him before. And then he said his name.
Oh, Jim. I did remember Jim. Suddenly the memories came like a landslide. He was the boy in grade school who had a very tough time. Perhaps you had a 'Jim' in your school. My Jim had to go through daily humiliation — not only inflicted by the students, but by our Grade 3 teacher, too.
You see, Jim was dirty. Which was hardly the fault of an eight-year-old boy — one can only imagine what his home life was like. Every day, when Jim came to school his first task was to show both sides of his hands to the teacher. And if they were dirty (which they were — every day), she would hand him a bar of soap that she kept in her desk just for him. Off he would go to the washroom, then come back and show his hands again to see if he had passed the first 'test' of the day.
My eight-year-old self felt so horrified for him, in some way knowing something was wrong but not knowing what nor how to handle it.
I remember Jim at the sock hop, going from girl to girl, asking them to dance. Despite hearing no after no, he kept on, undeterred. When I was next in line, I remember all these conflicting feelings running through my head. I knew what I should do and I knew what I wanted to do.
We danced. But all the while I remember wondering what all the other girls were thinking.
At the library, Jim was quite animated. He knew about me, what I was doing and who I married. He said he read about me in the paper — so I thought maybe it was The Lance and that we lived in the same part of town.
"Where do you live?" I asked.
His answer shocked me.
"The Salvation Army on Higgins," he said. "I've been struggling with depression but I'm getting better."
He said this not with sadness but with pride and hope in his voice. We chatted for a few more minutes until a lady in the library shushed us. And we parted.
Later, as I sat in the class I had come to the library for, I realized that I did not do the very thing that I teach my clients to do. I did not ask "what's important now."
Surely if I had asked myself that question, I would have realized that sitting down with Jim and buying him a coffee would have been so much more valuable. I was really disappointed with myself.
The next day, I phoned the Salvation Army. While they won't tell you if a person is staying there, they will leave a message. I left my name and number and Jim called back quickly.
I told him I'd be happy to buy him a coffee and we made a plan. I went the to coffee shop and I waited. And waited. And waited.
Jim didn't show up. Jim didn't call. And that's the end of the story.
But I don't want it to be that end of the story. I want to tell Jim how sorry I am that he went through all that humiliation in school, I want to say that I'm sorry that I wasn't nicer, that I didn't buy him a coffee when we met at the library.
Everyone knows a Jim. What do you call yours?
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Libraries used to be such quiet spaces11/25/2014 5:36 PM 0
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Further interest rate rises have struck homeowners a blow in the wallet, adding more to their mortgage bills.
The Reserve Bank governor, Graeme Wheeler, raised the official cash rate from 3 per cent to 3.25 per cent yesterday - the third straight rise of 25 percentage points this year.
The latest increase adds about $15 a month to repayments on every $100,000 of mortgage debt, for a 20-year loan.
Many homeowners have already responded to projected rate rises earlier this year by switching all or part of their mortgages to a fixed rate.
These may initially higher be than a floating rate but, crucially, stay the same regardless of OCR rises for as long as the fixed-rate term lasts.
Reserve Bank figures published yesterday said that, since the start of the year, lending on floating rates had fallen by about $10 billion, and fixed-rate mortgages had risen almost as much.
Wellington Home Loan Shop broker Sloan McPhee said the past three to four days had seen an influx of people looking to fix their rates.
"It's been really noticeable over the last three days, or probably over the last three weeks. People are a lot more aware these days around interest rates and finances."
But he cautioned against fixing all of a mortgage. It was better to retain flexibility by keeping a small portion floating to pay it off faster.
ANZ became the first bank to say it would follow the Reserve Bank's lead, with rates across its range of mortgages to rise 0.25 per cent.
Its floating variable rate rose to 6.49 per cent.
While interest rate rises hurt borrowers, they help people with money in the bank.
ANZ has also lifted the interest rate on its high-interest savings account from 4.25 per cent to 4.50 per cent. Other banks are expected to follow suit.
The interest rate rises are another annoyance for people trying to get on the housing ladder, but experts said they would not be the deciding factor in the current market.
Real Estate Institute Wellington regional director Euon Murrell said the rises would not stop people borrowing to buy houses.
What was hurting the market was loan-to-value restrictions brought in by Wheeler in October to cool the housing market.
Murrell said it was targeted at a problem that was nowhere near as bad in Wellington as in Auckland and Christchurch.
"Yes, [interest rate rises] will have a small impact on mortgage repayments, both existing and new, but more to the point it is the loan-to-value restrictions that are having the most impact, especially with first-home buyers, and I am tired of the Reserve Bank's view on this.
"The pressure on the market is being driven by Auckland and the artificial Christchurch situation, created by the earthquakes . . .
"They must realise that the rest of the country is not experiencing this type of market so why penalise the provinces? New Zealand does not stop at the Bombay Hills."
- The Dominion Post
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CFTR: Domains, Structure, and Function
- Sreenivas Devidas,
- William B. Guggino
- … show all 2 hide
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Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF) (Collins, 1992). Over 500 naturally occurring mutations have been identified in CF gene which are located in all of the domains of the protein (Kerem et al., 1990; Mercier et al., 1993; Ghanem et al., 1994; Fanen et al., 1992; Ferec et al., 1992; Cutting et al., 1990). Early studies by several investigators characterized CFTR as a chloride channel (Anderson et al.; 1991b,c; Bear et al., 1991). The complex secondary structure of the protein suggested that CFTR might possess other functions in addition to being a chloride channel. Studies have established that the CFTR functions not only as a chloride channel but is indeed a regulator of sodium channels (Stutts et al., 1995), outwardly rectifying chloride channels (ORCC) (Gray et al., 1989; Garber et al., 1992; Egan et al., 1992; Hwang et al., 1989; Schwiebert et al., 1995) and also the transport of ATP (Schwiebert et al., 1995; Reisin et al., 1994). This mini-review deals with the studies which elucidate the functions of the various domains of CFTR, namely the transmembrane domains, TMD1 and TMD2, the two cytoplasmic nucleotide binding domains, NBD1 and NBD2, and the regulatory, R, domain.
- Akabas, M. H., Kaufmann, C., Cook, T. A., and Archdeacon, P. (1994). "Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator," J. Biol. Chem. 269, 14865–14868.
- Ames, G. F. L., Mimura, C. S., and Shyamala, V. (1990). "Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human traffic ATPases," FEMS Microbiol. Rev. 75, 429–446.
- Anderson, M. P., Berger, H. A., Rich, D. P., Gregory, R. J., Smith, A. E., and Welsh, M. J. (1991). "Nucleotide triphosphates are required to open the CFTR chloride channel," Cell 87, 775–784.
- Anderson, M. P., Rich, D. P., Gregory, R. J., Smith, A. E., and Welsh, M. J. (1991b). "Generation of cAMP-activated chloride currents by expression of CFTR," Science 251, 679–682.
- Anderson, M. P., Gregory, R. J., Thompson, S., Souza, D. W., Paul, S., Mulligan, R. C., Smith, A. E., and Welsh, M. J. (1991c). "Demonstration that CFTR is a chloride channel by alteration of its anion selectivity," Science 253, 202–205.
- Bear, C. E., Duguay, F., Naismath, A. L., Kartner, N., Hanrahan, J. W., and Riordan, J. R. (1991). "Cl− channel activity in Xenopus oocytes expressing the cystic fibrosis gene," J. Biol. Chem. 266, 19142–19145.
- Bear, C. E., Li, C., Kartner, N., Bridges, R. J., Jensen, T. J., Ramjeesingh, M., and Riordan, J. R. (1992). "Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)," Cell 68, 809–818.
- Berger, H. A., Travis, S. M., and Welsh, M. J. (1993). "Regulation of the cystic fibrosis transmembrane conductance regulator by specific protein kinases and protein phosphatases," J. Biol. Chem. 268, 22037–2047.
- Carroll, T. P., Morales, M. M., Fulmer, S. B., Allen, S. S., Flotte, T. R., Cutting, G. R., and Guggino, W. B. (1995a). "Alternate translation initiation codons can create functional forms of the cystic fibrosis transmembrane conductance regulator," J. Biol. Chem. 270, 11941–11946.
- Carroll, T. P., McIntosh, I., Egan, M. E., Zeitlin, P. L., Cutting, G. R., and Guggino, W. B. (1995b). "Transmembrane mutations alter the channel characteristics of the cystic fibrosis transmembrane conductance regulator expressed in Xenopus Oocytes," Cell Physiol. Biochem. 362, 160–164.
- Carson, M. R., Travis, S. M., and Welsh, M. J. (1995). "The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity," J. Biol. Chem. 270, 1711–1717.
- Cheng, S. H., Gregory, R. J., Marshall, J., Paul, S., Souza, D. W., White, G. A., O'Riordan, C. R., and Smith, A. E. (1990). "Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis," Cell 63, 827–834.
- Cheng, S. H., Rich, D. P., Marshall, J., Gregory, R. J., Welsh, M. J., and Smith, A. E. (1991). "Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel," Cell 66, 1027–1036.
- Cheung, M., and Akabas, M. H. (1996). "Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment," Biophys. J. 70, 2688–2695.
- Collins, F. S. (1992). "Cystic fibrosis: molecular biology and therapeutic implications," Science 256, 774–779.
- Cotten, J. F., Ostedgaard, L. S., Carson, M. R., and Welsh, M. J. (1996). "Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of the cystic fibrosis transmembrane conductance regulator," J. Biol. Chem. 271, 21279–21284.
- Cutting, G. R., Kasch, L. M., Rosenstein, B. J., Zielenski, J., Tsui, L. C., Antonarakis, S. E., and Kazazian, H. H. J. (1990). "A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein," Nature 346, 366–369.
- Dalemans, W., Barbry, P., Champigny, G., Jallat, S., Dott, K., Dreyer, D., Crystal, R. G., Pavirani, A., Lecocq, J. P., and Lazdunski, M. (1991). "Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation," Nature (London) 354, 526–528.
- Denning, G. M., Ostedgaard, L. S., and Welsh, M. J. (1992b). "Abnormal localization of the cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia," J. Cell Biol. 118, 551–559.
- Deversen, E. V., Gow, I. R., Coadwell, W. J., Monaco, J. J., Butcher, G. W., and Howard, J. C. (1990). "MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters," Nature (London) 348, 738–741.
- Drumm, M. L., Wilkinson, D. J., Smit, L. S., Worrell, R. T., Strong, T. V., Frizzell, R. A., Dawson, D. C., and Collins, F. S. (1991). "Chloride conductance expressed by ΔF508 and other mutant CFTRs in Xenopus oocytes," Science 254, 1797–1799.
- Egan, M., Flotte, T., Afione, S., Solow, R., Zeitlin, P. L., Carter, B. J., and Guggino, W. B. (1992). "Defective Regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR," Nature (London) 358, 781–584.
- Fanen, P., Ghanem, N., Vidaud, M., Besmond, C., Martin, J., Costyes, B., Plassa, F., and Goossens, M. (1992). "Molecular characterization of cystic fibrosis: 16 novel mutations identified by analysis of the whole cystic fibrosis conductance transmembrane regulator (CFTR) coding regions and splice site junctions," Genomics 13, 770–776.
- Ferec, C., Audrezet, M. P., Mercier, B., Guillermit, H., Moullier, P., Querec, I., and Verlingue, C. (1992). "Detection of over 98% cystic fibrosis mutations in a Celtic population," Nature Genet. 1, 188–191.
- Garber, S. S. (1992). "Outwardly rectifying chloride channels in lymphocytes," J. Membr. Biol. 127, 49–56.
- Ghanem, N., Costes, B., Giorodon, E., Martin, J., Fanen, P., and Goossens, M. (1994). "Identification of eight mutations and three sequence variations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene," Genomics 21, 434–436.
- Gray, M. A., Harris, A., Coleman, L., Greenwell, J. R., and Argent, B. E. (1989). "Two types of chloride channels on duct cells cultured from human fetal pancreas," Am. J. Physiol. 257, C240–C251.
- Gregory, R. J., Rich, D. P., Cheng, S. H., Souza, D. W., Paul, S., Manavalan, P., Anderson, M. P., Welsh, M. J., and Smith A. E. (1991). "Maturation and function of the cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2," Mol. Cell. Biol. 11, 3886–3893.
- Higgins, C. F., Hiles, I. D., Salmond, G. P. C., Gill, D. R., Downie, J. A., Evans, I. J., Holland, I. B., Buckel, S. D., Bell, A. W., and Hermondson, M. A. (1986). "A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria," Nature (London) 323, 448–450.
- Hwang, T. C., Lu, L., Zeitlin, P. L., Gruenert, D. C., Huganir, R., and Guggino, W. B. (1989). "Chloride channels in CF: Lack of activation by protein kinase C and cAMP-dependent protein kinase," Science 244, 1351–1353.
- Hwang, T. C., Nagel, G., Nairn, A. C., and Gadsby, D. C. (1994). "Regulation of the gating of the cystic fibrosis transmembrane conductance regulator Cl channels by phosphorylation and ATP hydrolysis," Proc. Natl. Acad. Sci. USA 91, 4698–4702.
- Hyde, S. C., Emsley, P., Hartshorn, M. J., Mimmack, M. M., Gileadi, U., Pearce, S. R., Gallagher, M. P., Gill, D. R., Hubbard, R. E., and Higgins, C. F. (1990). "Structural model of ATP binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport," Nature (London) 346, 362–365.
- Kerem, B. S., Zielenski, J., Markiewiz, D., Bozon, D., Gazit, E., Yahav, J., Kennedy, D., Riordan, J. R., Collins, F. S., and Rommens, J. M. (1990). "Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene," Proc. Natl. Acad. Sci. USA 87, 8447–8451.
- Kim, E., Niethammer, M., Rothschild, A., Jan, Y. N., and Sheng, M. (1995). "Clustering of the Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases," Nature 378, 85–88.
- Kim, E., Cho, K. O., Rothschild, A., and Sheng, M. (1996). "Hetero-multimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins," Neuron 17, 103–113.
- McCarty, N. A., McDonough, S., Cohen, B. N., Riordan, J. R., Davidson, N., and Lester, H. A. (1993). "Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator channel by two closely related arylaminobenzoates," J. Gen. Physiol. 102, 1–23.
- McDonough, S., Davidson, N., Lester, H. A., and McCarty, N. A. (1994). "Novel pore-lining residues in CFTR that govern permeation and open-channel block," Neuron 13, 623–634.
- Mercier, B., Lissens, W., Novelli, G., Kalaydjiev, L., DeArce, M., Kapranov, N., Canki-Klain, N., Lenoir, G., Chauveau, P., Lenaerts, C., Rault, S., Cashman, S., Sanguiolo, F., Audrezet, M. P., Dallapiccola, B., Guillermit, H., Bonduelle, M., Liebaers, I., Quere, I., Verlingue, C., and Ferec, C. (1993). " Identification of eight novel mutations in a collaborative analysis of a part of the second transmembrane domain of the CFTR gene," Genomics 16, 296–297.
- Morales, M. M., Carroll, T. P., Morita, T., Schwiebert, E. M., Devuyst, O., Wilson, P. D., Lopes, A. G., Stanton, B. A., Dietz, H. C., Cutting, G. R., and Guggino, W. B. (1996). "Both the wild type and a functional isoform of CFTR are expressed in the kidney," Am. J. Physiol. 270, F1038–F1048.
- Moser, J. A., Douar, A. M., Sarde, C. O., Kioschis, P., Feil, R., Moser, H., Poustka, A. M., Mandel, J. L., and Aubourg, P. (1993). "Putative X-linked adrenoleukodystropy gene shares unexpected homology with ABC transporters," Nature (London) 361, 726–730.
- Picciotto, M. R., Cohn, J. A., Bertuzzi, G., Greengard, P., and Nairn, A. C. (1992). "Phosphorylation of cystic fibrosis transmembrane conductance regulator," J. Biol. Chem. 267, 12742–12752.
- Reisin, I. L., Prat, A. G., Abraham, E. H., Amara, J. F., Gregory, R. J., Ausiello, D. A., and Cantiello, H. F. (1994). "The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel," J. Biol. Chem. 269, 20584–20591.
- Rich, D. P., Gregory, R. J., Anderson, M. P., Manavalan, P., Smith, A. E., and Welsh, M. J. (1991). "Effect of deleting the R domain on CFTR-generated chloride channels," Science 253, 205–207.
- Riordan, J. M., Rommens, J. M., Kerem, B. S., Alon, N., Rozmahel, R., Grzelvzak, Z., Zeilenski, J., Lok, S., Plavsic, N., Chou, J. L., Drumm, M. L., Iannuzzi, M. C., Collins, F. S., and Tsui, L. C. (1989). "Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA," Science 245, 1066–1073.
- Savov, A., Mercier, B., Kalaydjieva, L., and Ferec, C. (1994). "Identification of six novel mutations in the CFTR gene of patients from Bulgaria by screening the twenty-seven exons and exon/intron boundaries using DGGE and direct DNA sequencing," Hum. Mol. Genet. 3, 57–60.
- Schwiebert, E. M., Egan, M. E., Hwang, T. H., Fulmer, S. B., Allen, S. S., Cutting, G. R., and Guggino, W. B. (1995). "CFTR regulates outwardly rectifying chloride currents through an autocrine mechanism involving ATP," Cell 81, 1063–1073.
- Sheng, M. (1996). "PDZs and receptor/channel clustering: Rounding up the latest suspects," Neuron 17, 575–578.
- Sheppard, D. N., Rich, D. P., Ostedgaard, L. S., Gregory, R. J., Smith, A. E., and Welsh, M. J. (1993). "Mutations in CFTR associated with mild disease for Cl− channels with altered pore properties," Nature (London) 362, 160–164.
- Sheppard, D. N., Ostedgaard, L. S., Rich, D. P., and Welsh, M. J. (1994). "The amino-terminal portion of CFTR forms a regulated Cl− channel," Cell 76, 1091–1098.
- Siebert, F. S., Lindsell, P., Loo, T. W., Hanrahan, J. W., Riordan, J. R., and Clarke, D. M. (1996). "Cytoplasmic loop three of cystic fibrosis transmembrane conductance regulator contributes to regulation of chloride channel activity," J. Biol. Chem. 271, 27493–27499.
- Stutts, M. J., Canessa, C. M., Olsen, J. C., Hamrick, M., Cohn, J. A., Rossier, B. C., and Boucher, R. C. (1995). "CFTR as a cAMP-dependent regulator of sodium channels," Science 269, 847–849.
- Tabcharani, J. A., Chang, X. B., Riordan, J. R., and Hanrahan, J. W. (1992). "The cystic fibrosis transmembrane conductance regulator chloride channel. Iodide block and permeation," Biophys. J. 62, 1–4.
- Tabcharani, J. A., Chang, X. B., Riordan, J. R., and Hanrahan, J. W. (1991). "Phosphorylation-regulated Cl− channel in CHO cells stably expressing the cystic fibrosis gene," Nature (London) 352, 628–631.
- Valle, D., and Gartner, J. (1993). "Penetrating the peroxisome," Nature (London) 361, 682–683.
- Walker, J. E., Saraste, M., Runswick, M. J., and Gay, N. J. (1982). "Distantly related sequences in the α and β subunits of ATP synthase, myosin, kinases, and other ATP-requiring enzymes and a common nucleotide binding fold," EMBO J. 1, 945–951.
- Title
- CFTR: Domains, Structure, and Function
- Journal
Journal of Bioenergetics and Biomembranes
Volume 29, Issue 5 , pp 443-451
- Cover Date
- 1997-10-01
- Print ISSN
- Online ISSN
- 1573-6881
- Publisher
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Topics
- Keywords
- Chloride channels
- outwardly rectifying chloride channels
- review
- Industry Sectors
- Authors
- Sreenivas Devidas (1)
- William B. Guggino (1)
- Author Affiliations
- 1. Department of Physiology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205


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Reviews for Chaska Sweets & Snacks
by Honeydev333
one month ago
Was there last night with friends we ordered 3 curries and tandoori chicken . Their tandoori wasn't fresh that i can tell but loved their chaska special butter chicken completely indian style loved rest of curries aswell will come back surely for chaska special butter chicken ....
by Gaurav Verma
9 months ago
If anyone is fond of real quality of the Indian cuisine and authentic sweets in Auckland. Here is one and only place which is "Chaska" in Otahuhu at Auckland. I love the quality and taste of food here...:-)
by Jacky
May 06, 2012
yummy SAMOSA and NAN reminds me London `s take away. found this place with my work mate take me for quick lunch.well placed veg and non-veg options THALI (pre plated). good to be have SAMOSA on really cheap price of $1.30 at Otahuhu.
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The family of a Dallas teenager Jakadrien Turner is demanding answers after she was deported to Colombia, despite the fact that she is a U.S. citizen and speaks no Spanish. Turner, a 15-year-old African-American runaway, was living in Houston when she was arrested for shoplifting and gave police a fake name that belonged to a 22-year-old undocumented immigrant from Colombia with warrants for her arrest. The Immigration and Customs Enforcement agency (ICE) reportedly discovered Turner's fingerprints did not match those of the Colombian national, but deported her anyway. "The country has no idea that we have got a rogue police force. That rogue police force is called ICE," says Ralph Isenberg, a Dallas businessman who has become an advocate for immigrants. "I'm hoping that Black Americans, who have a history of understanding the destruction of our families, because slavery done that to our families, will at some point wake up and understand that the problem of immigrants is something we cannot ignore," adds Dallas Reverend Peter Johnson, a longtime civil rights advocate who has worked with the Turner family. We also speak with Jacqueline Stevens, a political science professor at Northwestern University who recently published an exhaustive report on U.S. citizens who have been detained and deported. [includes rush transcript]
Occupy New Hampshire Member on His Exchange with Mitt Romney over Support for Corporate Personhood
Occupy New Hampshire activist Mark Provost made national headlines Wednesday when he attended a town-hall meeting hosted by Republican presidential candidate Mitt Romney and asked about his past comment that "corporations are people." Provost's question to Romney came as Occupy New Hampshire is preparing for a series of events leading up to the state's Republican primary to highlight the disproportionate impact corporations and wealthy donors have on the political process. We play an excerpt of the town-hall exchange and get Provost's response to Romney reply. "I think his response really, again, is this denial that there's this class in the country and that there are some people within the corporation, specifically the workers, that are taking it on the chin so that the United States' executive management can make massive bonuses, and serve their shareholders rather well, too, because the profits largely go to capital gains and dividends." [includes rush transcript]
Buddy Roemer: GOP Pres. Candidate Who Backs Occupy, Campaign Finance Reform, Excluded from Debates
We speak with Buddy Roemer, a candidate who is on the Republican ballot in New Hampshire but has not been invited to this weekend's two Republican debates—or any of the past 16 debates—even though he is a former governor of Louisiana and four-term member of Congress. Roemer's campaign is unusual in the Republican field: He has refused to accept campaign contributions more than $100, rejected all donations from political action committees, and has made campaign finance the key plank in his platform. He has also endorsed the Occupy Wall Street movement. "[President Obama] gets elected, and he says he wants change. But he takes all his money from these same corporations who don't want change," Roemer says. "Special interests control Washington. I've been there." [includes rush transcript]
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It was a dramatic scene in the Senate this week. As Sen. Elizabeth Warren, presiding, announced the defeat of the Keystone XL pipeline, a Crow Creek Sioux man from South Dakota sang out in the Senate gallery. A massive people's climate movement against extracting some of the dirtiest oil on the planet had prevailed ... at least for now.
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NHL on NBCSN: Will Rangers' Nash return to face Boston?
Nov 19, 2013, 8:47 AM EST
NBCSN continues its coverage of the 2013-14 campaign tonight when the New York Rangers host the Boston Bruins at Madison Square Garden at 7:30 p.m. ET. In addition to NBCSN, you can also watch the game online.
The Rangers have rebounded from their 3-7-0 start, but they're far from out of the woods. They have found the back of the net just three times in their last three games and rank near the bottom of the league with an average of just 2.1 goals per game.
They need to get Rick Nash (concussion) back, and there's a decent chance of that happening tonight.
Pro Hockey Talk's partner FanDuel is hosting a one-day $2,500 Fantasy Hockey league tonight (Tuesday). It's just $10 to join and first prize is $500. Starts at 7:00 p.m. ET. Here's the link.
The Rangers might also catch a break by avoiding Tuukka Rask, who has been one of the NHL's top goaltenders this season. Although nothing has been confirmed, Rask played in Carolina on Monday and the Bruins will face the St. Louis Blues on Thursday, so it wouldn't be surprising if backup Chad Johnson picked up a rare start to avoid wearing out Rask.
Even if Nash returns and Rask warms the bench though, the Bruins will be a challenging opponent for the Rangers. For starters, Boston has successfully killed off its last 32 penalties, including Hurricanes' 5-on-3 opportunity last night. The Bruins have also won five of their last six games to put them just one point shy of the Atlantic Division lead.
Boston ranks 10th in the league in goals per game, but in that regard their edge over the Rangers comes from their offensive depth. David Krejci has been cold lately, but Loui Eriksson is riding a six-game point streak. Brad Marchand has struggled to get anything going offensively this season, but 22-year-old Reilly Smith's sophomore season is off to a productive start. They're a team that remains a threat even when some of their better players aren't able to pull their weight.
Roughly a quarter of these two team's seasons are in the books and it looks like the race for playoff spots will be as tight as ever. In the Atlantic Division, just eight points separates first and sixth place. In the Metropolitan Division, the gap between first and sixth is just seven points. They'll need every edge they can get now to aide them in the battle for a postseason berth and seeding in April.
- heynyc61 - Nov 19, 2013 at 9:20 AM
Neither team can claim Consol Energy as it's home barn… Tonight they are at MSG. Can't wait since I'll be there in the bridges
- 11blueshirts11 - Nov 19, 2013 at 10:48 AM
I'm interested to see where Nash fits in if he in fact does return tonight. I think he'd fit well as a RW with Hagelin and Richards
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Marion County residents will have an opportunity to extend a Local Option Sales and Services Tax next Tuesday.
Keywords: LOSST, mayor darrel dobernecker, Tax
In just under two weeks, Marion County voters will be asked to weigh in on whether or not to continue a one cent local option sales tax.
Keywords: local option sales and services tax, march 1st, mayor darrel dobernecker, Vote
Will you be joining the crowds shopping on Black Friday?
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call: (641) 842-3161 | (641) 628-8672


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A myelin map brain surface image from a 65-75 year old healthy HCP Lifespan subject is featured on the October 31, 2014 Aging Brain special issue of Science.
Myelin mapping is being used in HCP provide useful markers between individuals for functionally distinct regions of the cerebral cortex, which can vary in size and location between individuals. One of the questions being asked in the HCP Lifespan pilot project is whether maps of myelin content change over the lifespan and how those changes might affect the function over the brain in healthy aging.
The image was produced in Connectome Workbench from a subject scanned in Lifespan Phase 1a who was recruited as a healthy control through the Knight Alzheimers Disease Research Center at Washington University.


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As a technology writer, Ariella Brown has covered including 3D printing, analytics, big data, bitcoin, cloud computing, green technology, marketing, and social media. She holds a PhD in English and taught college level writing before becoming a full time writer, editor, and social media consultant. Her best social media outlet of choice is Google+. YOu can also follow her on Twitter. Links to her portfolio, blogs, favorite quotes, and photos can be found at writewaypro.net.
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Hore relishing Highlanders return
ESPNscrum Staff
January 14, 2012
Andrew Hore still has international ambitions © Getty Images
All Blacks hooker Andrew Hore is relishing the chance to pull on the Highlanders jersey after years of turning out for their Wellington rivals.
The Kiwi international cut ties with the Hurricanes at the end of the 2011 Super Rugby in what was a mass exodus from the Wellington franchise. Hore was joined by the likes of Ma'a Nonu, Aaron Cruden and Piri Weepu in departing from the 'Canes and for Hore it provided him the chance to journey back to the south of New Zealand close to his farm in Maniototo.
"It has all worked out pretty well," Hore told the Otago Daily Times. "I have made a lot of good friends up there ... but there are no real regrets coming back here. Being a Highlander is something special and all my mates are ... supporters.
"I guess it sunk in when I realised I could just get in the car and drive to work rather than say goodbye to everyone, fill the suitcase up and head to Wellington. It is a new challenge with a new team and obviously we've got a new stadium. And I suppose I'll be able to go to my local pub and talk about how the Highlanders are going to go instead of getting grief about being a Hurricane.
"It is the breath of fresh air you need after reaching one [of] your major goals, which was the World Cup."
The Highlanders' first match of the 2012 Super Rugby season is on February 25 against Kiwi rivals the Chiefs and Hore hopes for a successful campaign.
"There is definitely a bit of a buzz here," Hore said. "If you could pick a time to come to the Highlanders, this would be it. Jamie has got a great bunch of guys and he has got some good coaches around him. They did a really good job last year and got some belief."
© ESPN Sports Media Ltd.
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The two sides of the Samoan coin
Samoa's Sivi Tau says the team "come completely prepared", the reality is a world away. Seilala Mapusua on Samoa and building a future


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Find records of Bernice Anderson
Find birth, death, marriage, military, and other records of Bernice M Anderson at Ancestry.com.Search for records
Biography & Family History Add details
Bernice M Anderson (1921 - 2008) was born on June 22, 1921. She was born into the Anderson family.
There are no known spouses or children on file for Bernice. Bernice died on March 25, 2008 at age 86.
Bernice M Anderson's last known residence is at Estes Park, Larimer County, Colorado.
This record of Bernice M Anderson comes from the United States Social Security Death Index. According to information provided to the SSDI, this death record has been verified by a family member of the deceased. This data can be considered very accurate. What is the SSDI?
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How to redo an old couch
By Chaya Kurtz, Networx
First, how gross is the couch in question? Has it been sitting outside, getting rained on and moldy? Have the filling/cushions rotted out or disintegrated? If we're talking about a couch that it is gross because it is moldy and rotten, or because Heaven forbid it has bedbugs, I'm going to say throw it out. Sorry. Some things are not salvageable. Remember the episode of Portlandia when Daniel and Meg go dumpster diving? I'm all for upcycling, but there's a limit, and that limit is any food that is unsanitary and couches that are literally rotten. K?
Now, if your couch is merely gross because the upsholstery fabric is ugly or dirty, then by all means take a stab at reupholstering it. First of all, it could be worth it to take your couch to a professional upholsterer. If that's out of your price range, then follow these tips, many of which I got from Amy of While Wearing Heels and All Things Thrifty.
1. Start by taking photos of the couch with its gross upholstery on it. You'll need them later. Take note of all of the details of the couch. Which parts of the upholstery are sewn? Which parts are stapled? Document the way the the couch is constructed well so that you can recreate it. The upholstery on the cushions will most probably be sewn. Do you have a sewing machine? Do you know how to make patterns? The most challenging piece will be recreating the cushion covers, as it will require sewing.
2. Next, slowly and carefully, remove the upholstery from the couch. OK, this is more easily said than done. Gently pry off the upholstery from the back and bottom of the couch. Try not to tear the fabric, as it helps to have it as a guide for cutting the size and shape of your new upholstery fabric. Save every single part of the couch that you remove from it.
3. Get out your vacuum cleaner and clean the couch. There will be treasures in there like food, dust, maybe money, and hopefully not bugs. Avoid tearing or otherwise damaging the filling while removing the old upholstery fabric and while cleaning.
4. The next step is cutting the fabric. You'll need to trace around the pieces that you removed. DO NOT cut the pieces exactly the size as the ones that you removed. YOU MUST cut them bigger. Now please do not say that I didn't warn you.
5. You are going to staple the fabric onto the frame of the couch. Use an electric staple gun. Again, don't say I didn't warn you.
6. It would be dishonest to say that I actually know how to sew couch cushions. However, they covered it in detail on Design Sponge.
Have you successfully reupholstered a couch? Do you want to share your tips with others? Please comment.
Source: http://www.networx.com/article/how-to-reupholster-a-gross-couch
Distributed by Internet Broadcasting. This material may not be published, broadcast, rewritten or redistributed.
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No police presence at homeless feeding on Fort Lauderdale beach


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Posts tagged with Ku Lgbt Resource Center
KU center promoting one-person, gender-neutral restrooms this week
If you've stopped by a restroom at KU's Sabatini Multicultural Resource Center — or, at certain times, the Kansas Union — and seen a sign out front labeling it as a "single-use, gender-neutral restroom," you may have wondered what that was about.
What it means is that any individual may use it, regardless of gender. And the signs are there because of a campaign by the KU Lesbian, Gay, Bisexual and Transgender Resource Center to create more restrooms in that format across campus.
The promotion, which is running this week, coincides with Transgender Awareness Month. Michael Detmer, a grad student who serves as resource coordinator for the LGBT Resource Center, says traditional men's or women's public restrooms can create uncomfortable situations, or even lead to harassment, for transgendered people and others who don't fit precisely into the categories of male or female. These gender-neutral restrooms provide a "safe space" for them, he said.
The center has been working for a few years to convert single-person restrooms around campus to the gender-neutral format, which Detmer said would also allow them to be used as family restrooms for people with children. The effort is taking some time, he said, because there is effort and cost involved in identifying restrooms that will work and in changing signs.
For now, the group has turned all the restrooms in the Multicultural Resource Center gender-neutral through tomorrow. Restrooms on the fourth floor of the Union underwent the switch for two hours earlier this week during an LGBT Resource Center event, and it will happen again from noon to 1 p.m. tomorrow during a visit from Stephanie Mott of the Kansas Equality Coalition, an LGBT rights group.
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- Regents, university officials fear budget cuts ahead November 19, 2014 · 32 comments
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- Letter: Not 'marriage' November 21, 2014 · 2 comments
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- Arrest made after Wichita woman raped, set on fire November 20, 2014 · 9 comments
- Haskell wants Title IX efforts to affect sexual, domestic violence across Indian Country November 3, 2014
- Lawrence Community Shelter executive director to resign after six months on the job November 20, 2014
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- Our Town Sports (Nov. 20, 2014) November 19, 2014
- Tuner Tom Eversole is the 'pit guy' of pianos on KU's campus April 26, 2012
- Pollard plays role of delivery guy November 20, 2014


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Native advertising is having its big moment. When done right, it has tremendous pull with consumers. According to Nielsen, native ads produce as much as an 82% in brand lift. An infographic from MDG Advertising says 70% of individuals reported that they would prefer "to learn about products through content rather than through traditional advertising."
Jul 14, 2009
SirsiDynix, a provider of library automation technology, announced the release of SirsiDynix Symphony 3.3. The release contains a number of features to increase overall staff efficiency, including acquisitions vendor interface ports (VIP), enhanced usability wizards, enhanced personalization for users, SIP2 patron authentication, staff web client, and horizon and dynix migrations. SirsiDynix also announched the release of SirsiDynix Web Reporter 3.3 for Oracle. web Reporter is a web-based reporting solution that uses MicroStrategy enterprise-level reporting tools. web Reporter 3.3 for Oracle works with SirsiDynix Symphony 3.3 for Oracle and further enhances this product by incorporating a number of updates, including six new report templates, 69 new reporting attributes and metrics, and 13 additional filters.


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In the loop
|| Print |
|Articles - April 2012
|Thursday, March 22, 2012
Giant Loop's founders set out to make motorcycle saddlebags that are functional and rugged, that look good strapped to a motorcycle and that would find an immediate audience among motorcycle adventurers worldwide. So far, the founders are three for three.
The Bend company's line of saddlebags, tank bags and other accessories are made of a 22-ounce, extra heavy-duty vinyl coated polyester wrapped in ballistic-strength Cordura nylon and held together with highstrength straps and clips, says co-founder Dave Wachs. Wachs and co-founder Harold Olaf Cecil took their inspiration from the gear used by outdoor enthusiasts in Central Oregon. In fact, friends at Bend-based Metolius Climbing, which is best known for its rock climbing harnesses, helped the pair design and build their prototype products.
The goal, says Olaf Cecil, was to make "an internal-frame backpack for a motorcycle."
"Everything available looked super dorky, but motorcycles are really cool," Wachs says. Rather than big, bulky bags, Giant Loop focused on slim, sleek bags that don't affect the performance of the motorcycle.
As for sales, the company went live with its retail website in September 2008 and sold its first bag within two hours of opening. Today, the company has 120 dealers nationwide and another eight international distributors. Giant Loop, which takes its name from the term for a long-distance motorcycle tour that begins and ends in the same place, now has eight products and has added two full-time employees.
Giant Loop was profitable from the first day by necessity as much as by choice. The company has no line of credit, no loans and no outside investors. What it does have is an enthusiastic customer base that inspires Wachs and Olaf Cecil to keep coming up with new ideas. Just don't expect anything dorky.
Reimagining education to solve Oregon's student debt and underemployment problemsNews
Thursday, November 13, 2014
How do we skill up our future technology workforce in a smart way to take advantage of these high-paying jobs? The answer shouldn't focus only on helping people get a bachelor's degree.
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I Know How You FeelNovember/December 2014
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Water WorldNovember/December 2014
Wednesday, October 22, 2014
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The short list: 5 hot coffee shops for entrepreneursContributed Blogs
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Oregon entrepreneurs reveal their favorite caffeine hangouts.
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Three problems with Obama's immigration orderNews
Wednesday, November 26, 2014
By now, anyone who knows about it has a position on President Obama's executive order on immigration. The executive order is the outcome of failed attempts at getting a bill through the normal legislative process. Both Obama and his predecessor came close, but not close enough since the process broke down multiple times.
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The 100 Best Companies survey is openNews
Friday, October 24, 2014
How does your workplace stack up against competitors? How can you improve workplace practices to help recruit and retain employees? Find out by taking our 100 Best Companies to Work for in Oregon survey!
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Is your business ready to join us in the call for action? This opening panel includes Oregon businesses who will discuss why they signed the Oregon Climate Declaration, the investments they are making to reduce carbon emissions, and how their actions are affecting their companies.
Get ready for two days of special events produced with the EPA, Portland Timbers and ISOS before and after the GoGreen Conference on October 16.
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More than 400 "Change Makers" will gather to invest in a socially sustainable community.
Sussman Shank LLP is pleased to announce that Dallas G. Thomsen and Victor J. Roehm have become partners of the firm.


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Castrol's Unlock your performance 1000rwhp Widebody Toyota Supra
Don't forget to follow me on Instagram @vicious_supra
I hate talking about my car on video because sounding like a douche bag is
usually inevitable but I couldn't pass up the chance of a professionally
filmed video of the car.
Big thanks to Matt Farah, Tom Morningstar, Cardomain, and Castrol.
The build video for the car is finally in the works, I apologize for
pushing it back over a year. I'm not sure how subscriptions work but I'll
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A sensible drive through the city on a very busy weekend night. All boring,
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The Black Beast Supra.
Subscribe to my new channel for updates on my GTR
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Skyline R32 GTR soundgasm
Attached some cameras on Asim Gondal's Left hand drive Nissan Skyline R32
It develops 598whp / 680nm on all 4 wheels (about 730hp 850nm in engine)
And in this video it shows some of it's power an noise. (To bad he had
old/faded brakes in this video.)
The video is from Rudskogen Motorcenter at the event GATEBIL.
R35 Skyline GT-R vs 67mm Supra in Mexico
45-189 mph pull, GPS verified. 2 jumps + 1 clean run.
Toyota Supra: 6765 billet wheel turbo,
HKS 264 cams, AEM, E85, ~700 rwhp
R35 GT-R: Cobb, LR Exhaust, intake and
hard pipes, etc, pump gas, est. ~580 whp
Raw footage from briank03's video:
R34 GTR 560 KW 25 Psi 'The Jetters Edge' Project Finished
From start to finish...... the Jetters Edge Car is now for sale! Thanks to
everyone who help build this street weapon!
Street Racing in Japan - BCNR33 GT-R vs BNR32 GT-R vs Evo
A street race in Japan between a BCNR33 Skyline GT-R, BNR32 Skyline GT-R,
and Mitsubishi Evo.
TunerLab.jp does not condone nor promote street racing as it is illegal and
dangerous, take it to the track!
R34 GTT - DriveThrough
I met up with more Skyline owners (plus others) and went for a drive.
Here's the video.
Tuner Skyline GT-R MEGA TEST- RB Japanese Muscle - Hot Version International
Go to http://gtchannel.com for more car videos and content. Before the
R35 GT-R, there was the "SKYLINE GT-R"...Featured cars : HKS R34 Skyline
GT-R, Hosaka R33 Skyline GT-R, Bee Racing B324R Drift Car, Esprit Z33 with
1119hp Skyline GT-R first testrun on the road
Bruntingthorpe: Skyline R34 GTR Launches
Placeholder video until I clean the car up and do some proper filming. Some
launches at Bruntingthorpe. Car is a 1999 Nissan Skyline BNR34 GTR, about
500 whp, Wiseco pistons, OS Giken STR clutch, HKS turbos and a load of other crap.
Supra speedo video, 1099 rwhp JamieP.
Subscribe to my new channel for updates on my GTR
Mine's R34 Vs. 3 Tuned R35 GT-R
check out my chanell for more !!
Lamborghini Aventador Twin Turbo Startup, Sounds, Acceleration, vs McLaren MP4-12C
Lamborghini Huracan vs McLaren MP4-12C Spider
McLaren 650S vs MP4-12C on the Dyno
GoPro Winner for October 2014 is Brad with a 2007 Volkswagen GTI
Which car is faster?
Similar 1/4 mile timeslips to browse:
1996 Toyota Supra E.Kanoo Drag Supra Titan: 7.036 @ 186.770
1993 Toyota Supra : 7.770 @ 184.000
Kean Wang, Engine: 3.4, Turbos: BL55-91 Tires: MT ET drags
1994 Toyota Supra NA-T: 7.778 @ 176.380
David Henry, Engine: 2JZGE, Turbos: GT4788 Tires: 33x12
1995 Toyota Supra Boost Logic: 8.190 @ 189.710
SW, Turbos: 91mm
1994 Toyota Supra turbo: 8.281 @ 183.150
Saad Saad, Engine: 3.0 litre 2jz, Turbos: 91 Tires: Mickey Thompson
1994 Toyota Supra TT: 9.010 @ 157.000
Darin Dichiara, Engine: 183ci toyota, Turbos: PT76-GTS Tires: MT ET Drag 28x10.5
1997 Toyota Supra Turbo: 9.194 @ 154.630
Alessandro de Luca, Engine: 2JZ, Turbos: Single
1994 Toyota Supra Turbo & Nitrous: 9.740 @ 142.000
Rich Eager, Engine: 2JZGTE, Turbos: BL71GTS Tires: MT
1998 Toyota Supra : 9.910 @ 144.000
Jarrett Humphreys, Engine: 2JZGTE 3.0L, Turbos: Garrett
2006 Ultima GTR : 9.945 @ 143.340
Richard Marlow,
1994 Toyota Supra Billet 71HPS Turbo: 9.980 @ 139.270
Kevin D, Engine: 2JZ, Turbos: Billet 71HPS Turbo Tires: BF Goodrich G-Force
1993 Toyota Supra turbo: 10.000 @ 136.000
carlos padilla, Engine: 2jzgte, Supercharger: none Turbos: t78 Tires: mt et street
1994 Toyota Supra : 10.050 @ 139.000
Humberto Aurbi, Engine: 3.0L, Turbos: Greddy T-78
1998 Toyota Supra : 10.130 @ 139.000
Jarrett Humphrey,
1997 Toyota Supra gt40r: 10.184 @ 132.150
Guy-guy Cloutier, Engine: 2jzgte stock, Turbos: gt4088r Tires: MT26x15x10
1995 Toyota Supra : 10.200 @ 139.000
Angel Robles, Engine: 3.0 twin turbo(2jzgt, Turbos: Greddy T-78 Tires: mt et streets 16
1995 Toyota Supra : 10.280 @ 141.000
Brad Daley, Turbos: t72 Tires: 26x10 ET Drag
1993 Toyota Supra : 10.360 @ 141.000
steve whittaker, Engine: 3100cc, Turbos: apexi rh6 x2 Tires: mickey t drag radials
1987 Toyota Supra : 10.386 @ 137.580
Jamie Daley, Engine: 3.0 liter 7MGTE, Supercharger: na Turbos: custom Garrett Tires: mt et drag
1994 Toyota Supra : 10.400 @ 130.000
Chris Anderson, Engine: 3.0, Turbos: HKS twin 2835 Tires: 26x10x15 mickey thompson
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text:
Facebook adding banks for IPO-sources
SAN FRANCISCO (Reuters) - Facebook Inc FB.N will add banks in coming weeks to help underwrite its initial public offering, two sources familiar with its plans said on Friday.
Deutsche Bank (DBKGn.DE), Credit Suisse CSGNNY.UL and Citigroup (C.N) are among the banks that will likely be added, said the sources, who requested anonymity because they were not authorized to speak publicly on the matter.
Last September, Facebook increased its credit line to $2.5 billion.
One of the sources said that the credit line may be increased to about $5 billion in the future.
In February 2011, Facebook set up a $1.5 billion credit agreement with affiliates of Morgan Stanley (MS.N), JPMorgan Chase & Co (JPM.N), Goldman Sachs (GS.N), Bank of America Merrill Lynch (BAC.N) and Barclays Capital (BARC.L), the leading underwriters of the company's IPO.
Facebook plans to increase its credit line to help cover a tax bill related to employee stock awards that will vest soon after it goes public.
On February 1, Facebook filed regulatory documents for an IPO.
Bloomberg reported earlier on Friday that Facebook would add banks to its roster of IPO underwriters.
A spokesman for Facebook declined to comment. Representatives for Deutsche Bank, Citigroup and Credit Suisse also declined to comment.
(Reporting By Alistair Barr; Editing by Bernard Orr)
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India approves $2.6 billion mounted gun purchase - official
India approved on Saturday the purchase of 814 mounted gun systems for the army at a cost of 157.5 billion rupees ($2.55 billion), a defence ministry spokesman said. Full Article
Intel's Valuation
Intel could rise 30 percent over next two years - Barron's. Full Article
Pope declares sainthood of two Indians, four Italians. Full Article
Stake Sale Strike
Coal India trade unions call off strike in victory for Modi. Full Article
Interview: Bulgari CEO
Bulgari CEO: we shouldn't have left India so we're back. Full Article
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Hamilton takes second F1 title in style. Full Article
Available For Remake
Bollywood finally wants to pay the price for remakes. Full Article
Davis Cup
Vintage Federer seals first Davis Cup for Switzerland. Full Article
Reuters India Mobile
Get the latest news on the go. Visit Reuters India on your mobile device Full Coverage


text:
A classic view of Tip and Bale's Bushhouse when it's inundated in flutes
Nobody knows what the objective of Tip and Bale's Bushhouse is. It used to have interesting activities, but Disney lawyers had it remodeled to further inflate their egos.
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