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One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe.
Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets.
"We eventually found that a single protein secreted when platelets are activated called human platelet factor 4 [hPF4] actually kills parasites that are inside red cells without harming the red cell itself," explains senior author Doron Greenbaum, PhD, assistant professor of Pharmacology, whose team studies innovative ways to fight malaria. The hPF4 targets a specific organelle of the Plasmodium falciparum parasite called the digestive vacuole, which essentially serves as its "stomach" for the digestion of hemoglobin. The investigators found that hPF4 destroys the vacuole with a deadly speed of minutes or even seconds, killing the parasite without affecting the host cell.
While host defense peptides appear to be attractive therapeutic agents, the expense of manufacturing this protein lessens its potential impact on the treatment of malaria. Greenbaum and colleagues set out to discover whether synthetic molecules mimicking the structure of HDPs could have similar beneficial effects against the Plasmodium parasite. After screening approximately 2000 small molecule HDP mimics (smHDPs) developed by biotech company PolyMedix, Inc. of Radnor, PA, Greenbaum and his team found that "all of the best hits had the same mechanism of action against Plasmodium parasites."
Like the natural hPF4 found in platelets, the most effective smHDPs tested targeted only infected red blood cells, attacking and destroying the parasite in exactly the same way, but with even greater potency and speed. "The smHDPs get into infected red cells and lyse or basically destroy the digestive vacuole or stomach of the parasite more rapidly than the hPF4 protein," Greenbaum notes. "The protein from platelets is about 25 times less potent, but the surprising thing is they act with the same mechanism. With ease, within seconds, they destroy the vacuole of the parasite."
Greenbaum's team settled on two compounds, PMX1207 and PMX207, for testing in mouse models of malaria. Both compounds significantly decreased parasitic growth and greatly improved survival rates, providing further confirmation of the potential of smHDPs as antimalarial agents. The work, Greenbaum says, shows that "we can translate a natural arm of the innate immune system in platelets to drug-like small molecules that we are honing to become potent, selective, potentially less toxic, and cheaper to make as an antimalarial."
Aside from their great effectiveness, smHDPs may have several other advantages over other antimalarial therapies. As Plasmodium inevitably adapts and becomes resistant to a particular drug therapy, the efficacy of that treatment decreases and survival rates drop. By mimicking the body's own natural defenses, the new HDP-centered approach could avoid that pitfall. "Certainly with malaria we've had a lot of problems in the last 20 years with resistance," Greenbaum explains. "One of the unique features of the synthetic HDPs is that studies show that pathogens have a difficult time generating resistance to them, because they attack membranes, not proteins. So they might be intrinsically more difficult to become resistant against."
Although Greenbaum's team focused mostly on the chronic red-blood-cell stage of malaria, their HDP-mimic also shows promise against other stages of the disease. "We think that the mimics would be useful as a transmission-blocking therapeutic," Greenbaum says. "In other words, you prevent transmission from human to mosquito and therefore back to human again. We have positive data for those two stages. It's becoming increasingly more important in antimalarial drug development that people think more and more about multistage inhibition."
The next step for Greenbaum's team is to further hone the selectivity and potency of the smHDP compounds, while developing them into drugs that can be orally administered. As Greenbaum explains, practical antimalarials need to be "taken as pills rather than having to be used intravenously, which is not going to be appropriate for treatment in endemic countries, especially in more rural environments."
University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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A novel kind of nanoparticle could lead to more effective cancer treatments.Patients and doctors often don't know if surgery to remove cancerous tissue was successful until scans are performed months later. A new kind of nanoparticle could show patients if they're in the clear much earlier.
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Just down the road from Facebook and Google, Dr. Phil Wagner runs a laboratory dedicated to optimizing the performance of some of the world's top athletes. At Sparta Performance Science in Menlo Park, California, Wagner and his team bring the spirit of Silicon Valley to bear on the athletic world, helping athletes find the tiny advantages that add to championships. Join us for a trip inside the lab to see where sports meets science.
Pieter Cohen, an internist in Massachusetts, got interested in dietary supplements several years ago, when some of his …
The risk of overdiagnosis and false positives means the UK may be barking up the wrong tree in trialling a wider target age range for breast screening


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Find an Internship or Volunteer in Miami Springs, Florida ( FL )
If you're looking for internships or volunteer work in Miami Springs, Florida or even to get a summer job, you've come to the right place! With over 30,000 around the county, chances are that GrooveJob.com has the right job for you and wants to be your only source for finding internships and volunteer positions in Miami Springs, Florida.
We've got plenty of intern and volunteer work in Miami Springs, Florida. Check out the list of employers below who have positions in Miami Springs. Remember to check back with Groovejob.com on a regular basis. We add new internships and volunteer jobs listings to our database every week, so you'll find new opportunities every time you check back with us.
|Browse by Employer (Click On Logos)
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Customer Business Development (Sales) Internship
…and have selling and account management responsibility. Responsibilities during the internship include achieving superior in-store...
Miami, FL
…Department. The following departments within FIU Athletics are seeking an unpaid intern : DEVELOPMENT (2 Positions) The internship ...
Miami, FL
Fall Internship (Bilingual) Latin Music, Miami Office
…of our operations is the production, marketing and sales of **LATIN** music. Intern assignments will vary depending on department...
Miami, FL
Fall Internship Audience Insights & Analytics
*Title: Fall Internship Audience Insights & Analytics* *Location: Miami, Florida* * General Summary:* The Audience Insights and...
Miami, FL
2014 Internship Location: Miami, FL Exempt/Non-Exempt: Non-Exempt Employment Type: Seasonal - Part Time Department: Other Description:...
Miami, FL
Fall Internship : Management Trainee-North Miami Dade/ Central Broward
…coffee Our interns go at a highly energized pace. From day one as a paid intern with Enterprise, you'll learn what it takes to run a...
Miami, FL
Tax Internship Positions ( Miami_FL)
Tax Internship Positions Job # CR005 KPMG LLP, the audit, tax and advisory firm (www.kpmg.com/us), is the US member firm of KPMG...
Miami, FL
Fall LATAM Legal Internship
## Primary Location Position: Fall LATAM Legal Internship Location: Coral Gables, FL Compensation: Paid Hours: Approximately 20...
Coral Gables, FL
Audience Research and Analysis Internship
…& supporting our International Television group for Latin America this year long internship is for full-time students going into...
Coral Gables, FL
Student / Intern
*Title: Student / Intern * *Location: FL,Florida-Miami* This job code is utilized for the majority of our temporary hires. The individual...
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Marketing Communications Intern - Fall 2014 - (Sports Media/PR/Broadcasting)
Overview of the Internship : The Marketing Communications Intern main job function is to assist the Director of Marketing Communications...
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Title: International Trade Internship -- 6 Month Assignment Location: US-FL-Coral Gables Job Number: COR00345 The International Trade ...
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Sports Management - Digital and Social Media Intern
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Miami Lakes, FL
Audience Research and Analysis Internship - Entertainment and Media Industry Opportunity
…Universal Networks International also operates Movies 24. Career Level Co-op/ Intern Country United States State/Province Florida City...
Coral Gables, FL
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engineering jobs near Cudahy, WI
Voice/ IP Telephony EngineerNEW
Software Folks, Inc. (dba Saviance Technologies)- Milwaukee, WI
Voice IP Telephony Engineer Location Milwaukee, WI Fulltime Skill Set Cisco Prime Cisco IP Telephony (CME, CUCM, SIP, E1, T1, PRI, MGCP, SRST, ACD CAC, Voice Gateway and voice...22 hours ago from Dice
Sr. Reliability Engineer - Plant Maintenance - Relo to Davenport, IowaNEW
Pacific Technical Resources- Milwaukee, WI
Engineering recruitment along with a holistic recruitment philosophy of valuing ... Pacific Technical Resources, LLC IT/Engineering Recruitment Professionals...16 hours ago from Zip Recruiter
Web DeveloperNEW
Technosoft Engineering- Oak Creek, WI
with hardware engineers and other engineering staff to evaluatedevelop ... Bachelor's degree in SoftwareComputer Engineering discipline from four-year college...18 hours ago from Dice
Software EngineerNEW
Corporate Technology Solutions- Milwaukee, WI
Company Description: We are a full-service Information Technology consulting firm headquartered in Milwaukee, WI. We partner with clients to manage, design, build and implement...16 hours ago from ZipRecruiter
Capital Sales Engineer- CNC Machine ToolsNEW
Morris Midwest- Milwaukee, WI
tools, tooling and accessories, and related engineering and support services, is seeking ... the territory. This role collaborates with Engineering, Service, Contract Administration...22 hours ago from ZipRecruiter
System EngineerNEW
Exacta- Brookfield, WI
Company Description: Since 1976 EXACTA Corporation has been enabling companies to build highly skilled, performance-driven teams in Information Technology. EXACTA's uniquely...10 hours ago from ZipRecruiter
Principle Systems Electrical EngineerNEWMilwaukee, WI
high technology products within a concurrent engineering environment. Defines interface ... field required. Masters in Electrical Engineering preferred United States...1 hour ago from IvyExec
Plant Engineering Manager - FoodNEW
Management Business Solutions- Milwaukee, WI
a safe working environment Ensure that Engineering/Maintenance programs are ... QUALIFICATIONS: Bachelor's degree in engineering 10 years of progressive leadership...10 hours ago from ZipRecruiter
Software EngineerNEW
Exacta- Brookfield, WI
software product Computer Science or Engineering degree or equivalent experience Required: Working knowledge of VB.NET, C#, and VB Script Knowledge of PHP, ASP and ASP.NET...22 hours ago from ZipRecruiter
Plating Chemist/EngineerNEW
Spectrum Aluminum Finishing- Muskego, WI
Company Description: We are a successful metal finishing service company that has been in business since 1994. We are a growing company that offers a competitive compensation...10 hours ago from ZipRecruiter
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Book Clubs & Writers' Groups
Library Branch
Toronto Reference Library
The European Book Club is a co-operation of the European Union National Institutes for Culture (EUNIC) in Toronto. Read and discuss books by contemporary European authors, in English translation. This evening will be presente...
Mimico Centennial
Join the book club for an informal book discussion, with lively and stimulating conversation. New members welcome.
Tue Jan 27
Tue Feb 24
Tue Mar 24
Northern Elms
Join Library staff for entertaining book talks. Refreshments will be provided.
Thu Dec 04
Thu Jan 08
Thu Feb 05
Thu Mar 05
Northern Elms
Come and share your love of books and listen to others present their favourites in an informal, lively setting.
Fri Dec 12
Fri Jan 09
Fri Feb 13
Fri Mar 13
Afternoon Book Club meets at 2:00 p.m., the fourth Friday of every month and is open to all interested book lovers in the community. November's book is Sister by Rosamund Lupton. For more information or to register visit the ...
Fri Nov 28
Mimico Centennial
Discuss new books and old favourites with library staff. Call branch at 416-394-5330 for more information.
Thu Jan 29
Thu Feb 26
Thu Mar 26
Would you like to read and discuss an interesting book each month?...
Wed Dec 03
Afternoon Book Club meets at 2:00 p.m., the fourth Friday of every month and is open to all interested book lovers in the community. For more information or to register visit the branch or call 416-396-8890.
Fri Jan 23
Fri Feb 27
Fri Mar 27
Meet other writers and enthusiasts. Find inspiration and share your work in an informal, supportive environment. Writers of all genres are welcome. To register, call 416-396-8890.
Fri Dec 12
Fri Jan 09
Fri Feb 13
Fri Mar 13
Aimez-vous lire en français? Si vous voullez participer à des dicussions stimulantes contactez Céline au 416 395-5762.
Mon Jan 12
Mon Feb 02
Mon Mar 02


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About Ed McMahon
Ed McMahon
Ed McMahon
Ed McMahon is a 19-year veteran of the New Hanover County Sheriffs Office who started his work at the office as a patrol deputy.
When Sid Causey retired in the summer of 2009, McMahon, a Democrat, was appointed to finish out Causeys elected term.
He then won his first election as sheriff. While campaigning, McMahon said his goal is to treat everyone equally under the law. He also said he wants to make the office as accountable to the citizens as possible, in part, by being open with the media so citizens know what deputies are doing.
Raised in a small town in Massachusetts, McMahon graduated from Liberty University. He started his law enforcement career in 1988 with the Vermont State Police before moving to the New Hanover County Sheriffs Office in 1991. While at the office McMahon has worked as a detective, a school resource officer, a hostage negotiator and a member of the Emergency Response Team.
He has served as the assistant division commander of the Detectives Division, captain of the Support Services Division and as chief deputy.
On his campaign Web site, McMahon says he hates crime and its effect on victims, but not criminals who are people too.
He married his wife, Teena, in 1982 and they are the parents of two adult children.
Stories that mention Ed McMahon
Brunswick County to equip deputies with body camerasPublished November 25, 2014
County commissioners approved allowing the sheriff's office to shift funds allocated for other expenses.
Editorial - Changes to inmate policies could put strain on local jailsPublished November 16, 2014
Changes in how the state handles prisoners convicted of misdemeanors could cause jail populations to bulge.
Justice Reinvestment Act leads to increasing local jail populationPublished November 10, 2014
Even though the county jail population has grown, officials say the fluctuating numbers aren't cause for concern.
New Hanover's McMahon, Pender's Smith re-elected to sheriff's postsPublished November 4, 2014
Both incumbents are longtime sheriffs
Letters to the Editor - Oct. 22, 2014Published October 21, 2014
For more than a year, the Education Roundtable of the League of Women Voters Lower Cape Fear has met to study education issues in our area. We have an observer corps who attended school board meetings in Brunswick and New Hanover counties. We have...


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Awkward Colt McCoy Interview After Cowboys Game on Monday Night [VIDEO]
Redskins fans enjoy your week. A tough loss for the Cowboys Monday night, but this moment after the game made me laugh a little bit.
Redskins fans enjoy your week. A tough loss for the Cowboys Monday night, but this moment after the game made me laugh a little bit.
Alice in Chains have unveiled their 'Phantom Limb' video, plus much more, via a new BitTorrent Bundle.
The website Rooster Teeth recently held a 24-hour live stream fundraiser to raise money for Children's Miracle Network hospitals.
Nearly $250,000 was raised, which is pretty awesome.
Besides raising a ton of dough, one of the highlights of the fundraiser was when LeVar Burton, of "Reading Rainbow" fame appeared and read the book "Go the F**k to Sleep" to a group of people gathered on set.
Maybe I should attach one to my tequila bottle for tonight during the Cowboys game.
I can't stress this enough once again, why don't we have this in America?
Aaron Lewis has apologized after his flub at the World Series, mixing up the lyrics to the National Anthem in a performance prior to Game 5.
It's been a while since Staind singer Aaron Lewis has been in the news.
Now, he's got a noteworthy stain to add to his body of work: screwing up the National Anthem before the fifth game of the World Series.
A California Highway Patrol officer in Dublin, Calif., is in trouble for a bit of an invasion of privacy after booking a woman on DUI charges.
A marriage proposal done right.
Quick, somebody get this dog to teach his pals his latest trick.
With recent posts like the guy who had a moth stuck in his ear, I thought it to be a good time to compile more gross videos, perfect for watching in a group to see which of your friends will puke first.
I have heard they have been making a Halo movie for close to a decade now. Who knows if they will ever do it, but this little mini series could be as close as we get.


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"Charlie Brown says that we're put here on earth to make others happy." "Is that why we're here? I guess I'd better start doing a better job… I'd... Read More
Every entrepreneur is a leader. You might not have a staff right now, but you could in the future. Furthermore, as a business owner you are a community leader as well. So even if you're still a... Read More
When you boil it down, productivity is a string of tasks completed in the most efficient way possible. But how can you measure efficiency without a set deadline or goal? The fact is, deadlines can... Read More


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Holiday Gift Guide 2012
As you page through this year's Holiday Gift Guide, there's more here than meets the eye.
In addition to festive ads and clever gift ideas, you are experiencing the magical spirit of shopping local.
The businesses who advertise and provide featured products are special. By advertising, they support this Gift Guide, each other, and all of us in a larger effort— keeping our communities commercially strong and vibrant. In appreciation, we ask that during this holiday season—and all year long—you visit them and spend your dollars close to home. And, as long as you're there, it wouldn't hurt to mention that you stopped by because you saw them in this guide. We are a small, local business ourselves, after all.
To sweeten the deal, if you send us an email telling us about a recent shopping experience prompted by this guide, we'll enter your name into a raffle for a $75 gift certificate.
Browsing can really pay off!
Sarah Corbin, Shopping Feature Writer
See a full version of Holiday Gift Guide here:
Reader Comments
2 Comments - Add Your Comment
firstname.lastname@example.com from Oak Park
Posted: December 6th, 2012 5:25 PM
And thanks to Rosie, OakPark.com editor, who put in lots of hours to make sure we could share this whole section on-line today.
firstname.lastname@example.com from Oak Park
Posted: December 6th, 2012 5:23 PM
A lot of group effort goes into producing a section like this. 36 pages of gifts and advertisers means our in house design teams work around the clock to make sure it all looks wonderful. Yes that's right this is community journalism and our design team works right down the hall from all of us. (not miles and miles away) Elisha-Rio Apilado did all of the design lay out with a bunch of help to get the products "cut out" to look beautiful on the page.
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Ohio family welcomes home blind dog they gave away years ago
Updated On: Mar 27 2013 02:09:30 PM EDT
A Clifton family who gave away their blind dog got a sweet surprise.
Two years ago, the Sloan family adopted Carrot. The hound was blind in her left eye and with two small children, they decided to give her to another family in Price Hill.
Last week, Carrot came back to the Sloans.
"It looks like she was coming home. She was found two blocks away. She could have run in any other direction but she chose to come to Clifton," Kristen Sloan said.
Carrot was malnourished but the Sloans nursed her back to health.
They said they were so surprised to have her home. Now that their kids are older, they said they aren't about to make the same mistake twice. The Sloans have decided to keep Carrot.
Copyright 2013 by WLWT.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Family vacation to Disney World turns to tragedy after 5 killed in late-night crash in Louisiana
Outer Loop reopens in Parkville area
Inner Harbor's new Ice Rink opens Friday
Attorney: Police had 'duty' to cite teen son in fatal crash that killed 5 family members
Police make arrest in connection with road rage incident


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Welcome to the second annual tFS Style Awards! Nominated by our fashion-addicted forum members and voted on by our readers, the Tiffies recognizes exceptional contributions in fashion design, advertising, modeling, editorial and entertainment for 2014.
Vote for your favorites in 14 categories below through November 24, 2013. Winners will be posted on theFashionSpot.com in December.
images: IMAXtree


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My Favourite Album: Best of the Guardian blog (Guardian Shorts Book 1)
The Guardian (Author), Tim Jonze (Editor)
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How do you choose your favourite album? It seems that the answer is: you don't, they choose you.Some of the Guardian's most respected writers explain how they came to discover and love their favourite albums. From Jon Wilde's moving piece on Louis Armstrong's Hot Five and Hot Seven, to Laura Barton'... Read More
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Home » News » Religion
'Black Madonna' icon Masses in Manchester
"This pilgrimage is intended to awaken the faithful about the urgency of defending life from the moment of conception," said Father Peter West, vice president of HLI and chairman of the pilgrimage committee.
The Mass will be celebrated with the organization, Helpers of God's Precious Infants. After Mass there will be a public procession to Planned Parenthood on 24 Penacook St.
On Monday, the icon will arrive at Our Lady of the Cedars Church, 140 Mitchell St., Manchester, at 11 a.m. The icon will be displayed there for the service of Akathist at noon and 3 p.m., and for a celebration of the Divine Liturgy at 7 p.m.
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Person found dead in Manchester alley


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Categories: camera bags, Deals
Kata 3N1-33 DL Sling DSLR Backpack for $74.99 – Deal Alert
Published on March 18th, 2014
Written by: Eric Reagan
Adorama has the Kata 3N1-33 DL sling backpack, which holds a pro DSLR with a long zoom lens attached and 5-6 lenses, a 15.4″ laptop and other accessories, for $74.99 (reg. $149.99). Check it here at Adorama.
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Winnipeg Free Press - PRINT EDITION
One-third report abuse as a child
New study pins rate nationally, regionally
Almost one-third of adult Canadians were abused as a child and many of them struggle with mental-health issues, according to a study led by a University of Manitoba professor.
Study lead and U of M professor Tracie Afifi said her findings that 32 per cent of adult Canadians have experienced child abuse is consistent with the rate of child abuse in other countries.
"I think people often don't realize how prevalent child abuse is in Canada and that we really need to be investing in preventing child abuse from occurring," said Afifi, an associate professor in the departments of community health sciences and psychiatry.
Afifi's team of researchers from the University of Manitoba took data from more than 23,000 adults 18 and older from across Canada who participated in the 2012 Canadian Community Health Survey: Mental Health.
Details of the study were released Tuesday in the Canadian Medical Association Journal.
Their research indicates sexual abuse, physical abuse and exposure to intimate-partner violence is associated with mental-health issues including depression, bipolar disorder, anxiety disorder, alcohol abuse/dependence and drug abuse/dependence.
Afifi said the study didn't ask "Were you abused?" because studies have shown some people who have been abused don't characterize their experiences as such.
Instead, the questions asked whether respondents were slapped on the face or head, spanked with a hard object, pushed, grabbed, shoved or had something thrown at them to hurt them. For both those questions, respondents were asked to say yes only if the behaviour had happened a minimum of three times.
Another question asked whether respondents were kicked, bit, punched, choked, burned or physically attacked at least once.
Sexual-abuse questions were designed to determine whether respondents were forced into unwanted sexual activity. The questions asked people whether as children they had seen their parents, step-parents or guardians hit each other or other adults in the home three or more times.
Overall, physical abuse was the most common; 26 per cent of respondents said they had experienced physical abuse. Ten per cent of respondents said they had experienced sexual abuse and nearly eight per cent witnessed intimate-partner violence.
Men were more likely than women to have experienced physical abuse, 31 per cent versus 21 per cent. But women were more likely to have experienced sexual abuse, 14 per cent versus nearly six per cent.
But no matter the type of abuse, Afifi said it was linked to mental-health issues.
"Even the least severe act of physical abuse that we examined was still across the board, associated with our 14 different disorders," Afifi said.
The report shows that Canada's western provinces had the highest rates of child abuse with Alberta and British Columbia at 36 per cent and Manitoba at 40 per cent. Newfoundland and Labrador had the lowest rates of abuse at 21 per cent.
Afifi said her study didn't look at why the western provinces have higher rates but said it likely has to do with socio-demographic factors.
Ron Kane, director of clinical services at Macdonald Youth Services, said many factors play into child abuse and it would be hard to say why Manitoba has such a high rate.
"You can point to poverty, you can point to violence in communities, unemployment, inadequate housing, poor coping skills -- a whole array of potential factors, but it's difficult to say that there's more of that goes on in Manitoba than anywhere else."
No matter what the cause, Afifi hopes the study will help make health professionals aware of the relationship between child abuse and mental-health issues.
"If a child has experienced abuse, it's really important to pay attention to their mental health so that you can intervene to try to prevent those mental disorders from occurring."
This type of study cannot prove cause and effect, it can only point to possible links.
The Canadian Community Health Survey excluded native communities, people living in the three territories, full-time members of the Canadian Forces and people living in institutions.
-- with files from The Canadian Press
Republished from the Winnipeg Free Press print edition April 23, 2014 C12
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Police identify city's latest homicide victim7:05 PM 0
Winnipeg police released the identity of Winnipeg's latest homicide victim Saturday and appealed to the public to help identify her ...
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Originally published August 2, 2014 at 8:02 PM | Page modified August 3, 2014 at 4:15 PM
Mariners' offense suddenly looks textbook in 6-3 victory over Baltimore
Austin Jackson and Dustin Ackley get on base, and Robinson Cano and Kendrys Morales drive them home.
Seattle Times staff reporter
Mariners @ Baltimore, 10:35 a.m., ROOT Sports
BALTIMORE — This is how it's supposed to work.
The hitters at the top of the lineup reaching base and the hitters in the middle of the order driving them home.
It hasn't happened often for the Mariners this season, and certainly not since the All-Star break. But Saturday night at Camden Yards it all came together in a 6-3 victory over the Baltimore Orioles.
Newly acquired Austin Jackson, who was batting leadoff, and hot-hitting Dustin Ackley batting behind him, combined for five hits, scored four runs and reached base six times.
Robinson Cano and Kendrys Morales drove in five of the runs, and baseball, particularly scoring runs, seemed pretty easy on this night. The Mariners are 41-10 when scoring four or more runs.
"That's a good recipe for winning," Seattle manager Lloyd McClendon said.
The first example of that recipe came in the fifth with the score tied 1-1.
Jackson picked up his first hit as a Mariner with a leadoff single. Ackley, who has been one of the team's most productive hitters since the All-Star break, doubled to right field to put runners in scoring position.
Unlike past games, the Mariners didn't squander this opportunity. Cano belted his eighth homer, hammering a 1-1 changeup over the wall in right field off Orioles starter Miguel Gonzalez to make it 4-1.
"Robby came through big time for us there," McClendon said. "He loves hitting in this ballpark, and tonight was indicative of that."
All eight of Cano's homers this season have come with runners on base. It was his 29th career home run against the Orioles — the most of any opponent — and his 15th at Camden Yards.
"It's about time," Cano joked. "Somebody asked me if I see the ball better here, but I think it's just a ballpark I've been successful in. There's nothing special."
The recipe worked again in the top of the ninth inning. Jackson came up with a two-out single to right field. Orioles manager Buck Showalter called on his fifth pitcher of the night — lefty T.J. McFarland — to face the left-handed hitting Ackley. But the move backfired. Ackley reached on infield single — his third hit of the game. McFarland hit Cano with a pitch to load the bases. Morales drove in some big insurance runs, hammering a single into right field to make it 6-2.
"That was a big hit for us," McClendon said. "It's starting to come around for him."
Besides the new-look lineup, the Mariners welcomed back starter James Paxton from the disabled list. He wasn't great, but showed hints of dominance, pitching 41/3 innings and giving up two runs on four hits with three walks and five strikeouts.
In the first inning, Paxton looked like a pitcher who hadn't thrown in a major-league game since April 8. He walked Nick Markakis on five pitches to start the game and then served up a double to Manny Machado to put runners on second and third. Adam Jones scored Markakis with a ground ball to make it 1-0. Paxton made sure things didn't get worse, striking out Nelson Cruz and Delmon Young to end the inning.
"We thought he'd be a little pumped up, a little over-amped and little rusty," McClendon said. "Once the game got going, I thought he was extremely efficient."
In the second inning, Paxton walked a batter and was in trouble again. But Ackley helped him out with a nice sliding catch on Markakis' soft liner to left field to end the inning.
Ackley then followed up his glove work with some yard work, tying the score in the top of the third inning with a solo homer to right field off Orioles starter Miguel Gonzalez.
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Temperatures moderate by this weekend.
Today will feature cloudy skies with light snow with some accumulation, especially along the lakeshore. Temperatures will be around 30°. Winds will be south at 10-15 mph. Wind chills will be 19-22°.
Saturday will be partly cloudy and milder with highs in the low to mid 40s.
Sunday will be mostly cloudy and turning colder with temperatures close to 50. Some light rain is possible overnight.
Monday will be partly cloudy and colder with highs in the mid 30s.
Tuesday will be mostly sunny and milder with highs in the mid 30s. Some rain is possible for the overnight hours.
Wednesday will be partly cloudy with highs in the upper 30s.
The 6-10 Day Outlook for Wed. Dec. 3 through Sun. Dec. 7 calls for near average temperatures and above average precipitation. Average highs are around 38-39°with average precipitation of 0.46".
The 8-14 Day Outlook for Fri. Dec. 5 through Thu. Dec. 11 calls for near average temperatures and near average precipitation. Average highs are around 36-39° with average precipitation of 0.61".
Have a great day!
Meteorologist Aaron Ofseyer


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Matthew Vaughn to Produce FANTASTIC FOUR Reboot for Fox
Matthew Vaughn, the acclaimed director behind KICK-ASS and X-MEN: FIRST CLASS, has officially signed on to produce Fox's upcoming FANTASTIC FOUR reboot. The news came today via Mark Millar, the infamous comic book writer who Fox hired in 2012 to oversee its upcoming Marvel Comics films.
Today, Millar Tweeted: "Just off the phone with Fox and some excellent news - Matthew Vaughn is producing Josh Trank's Fantastic Four reboot!"
As of now, the film is set for a Spring 2015 release.
According to Marvel, "The Fantastic Four is an internationally-renowned group of superhuman champions (often dubbed the world's premiere super hero team or the first family of super heroes) based in New York City and dedicated to the betterment of the world through scientific discovery and defense against evil."
The Fantastic Four are a long-time hot Marvel commodity. Fox has developed two films based upon them, including 2005's FANTASTIC FOUR and 2007's FANTASTIC 4: RISE OF THE SILVER SURFER. The films starred Ioan Gruffudd, Jessica Alba, Chris Evans, and Michael Chicklis.
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Skittles N Bitz
Crazy comedy sketches featuring your favorite video game characters!
The creation of Jay Donaldson, Kegel gets into all sorts of trouble!
Socially Awkward Male Virgins!
Pretty amazing man, nice to see an artist get so much success from an animation without using any talking in it at all (am I the only one who noticed that fact?). You must have a Wacom thing or something, I mean, if you had done all your visuals on the computer, it would've taken forever. Great stuff!
that was funny they all faked there death lol and did it say can you see this on the soda can 0.o
This was just amazing, I like the way the newgrounds characters were the schoolkids.
Loved it. All of it. Loved the lil twist at the end the most though.
oh noes!
You did it again. Another masterpiece.
Adopting the NG characters as cameos and putting your own spin on things scares me. o.0 Excellent stuff there.
(I liked the effect you did with the Tankmen's goggle reflection)
I would have liked to see more of Alien Homonid however =(
Number one for Pico day?


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Community Status Updates
Premier League Prediction stuff here. http://www.totalfootballforums.com/forums/forum/385-premier-league-prediction-league/ ----- also please note Week 14 Fixtures will be up later this week (games on 2nd/3rd Dec)Nov 24 2014 10:13 PM
Santa HaRv
I'd like to slip down your chimneyNov 23 2014 09:28 PM
ShinkansenShut up Scotland.
Yesterday, 10:51 AM
Mrs Ashley PardewSnared
Yesterday, 03:34 PM
MonarchYou can slip down where-ever you like.
Today, 03:02 AM
Does anyone in England know of an Italian premium clothes designer label called GAS... If so, what do you think about it?Nov 23 2014 06:07 PM
SirBalonVery nice! Think I'm gonna give them more of a try because I own too much Replay and Diesel stuff and I'm bored with it. Everyone's got that sort of thing and I want something different.
Nov 23 2014 09:20 PM
Mrs Ashley PardewWorn by people like The foxes, avoid
Nov 23 2014 10:07 PM
Nov 23 2014 10:19 PM
The Foxes
It's great #banter having no internet at home ! ! !Nov 20 2014 03:00 PM
BerserkerThat sucks mate, you should steal some from a neighbor
Nov 20 2014 11:43 PM
The FoxesIn other news my internet is sorted and I can now annoy you all on a more regular basis again.
Nov 21 2014 11:35 AM
Mrs Ashley PardewThat was how he initially had his internet Blake, the fucking bamp
Nov 21 2014 04:01 PM
If I make you breakfast in bed a simple Thank You will be enough, not all this " How did you get in my house " NonsenseNov 20 2014 02:08 PM
Mrs Ashley PardewAnd I said what about, breakfast at Bluewolf's?
Nov 22 2014 10:47 PM
BluewolfI'm up for that!! Breakfast on me Down the Cafe..
Nov 23 2014 04:47 PM
Mrs Ashley PardewSounds good mate, what bait do they do?
Nov 23 2014 10:06 PM
Okay, should I watch the new Hunger Games in cinema tomorrow, or Interstellar for a 2nd time?Nov 19 2014 09:37 PM
ASFHunger Games. Pointless to waste money to go see a movie you've already seen recently.
Nov 19 2014 10:36 PM
RabI'm going to see Interstellar for a second time on Sunday. Do you want to be out nolan'd by a scottish scrub? WELL? DO YOU?
Nov 19 2014 10:59 PM
RabToo late i've seen it twice
Nov 23 2014 10:02 PM
Had a great time at the Ball, actually i don't remember lol. They had to take me out of the room halfway thru the ceremony posting pics later .Nov 16 2014 01:53 PM
SirBalonCourt marshall was on the lines there lol hahaha
Nov 17 2014 06:54 PM
kuvanmarinerojo4lifeyes and no lol, the thing is this is the only night of the year when is totally acceptable to be wasted and nobody will say shit. As matter of fact everybody at some point got drunk... i was just the first one lol. pics are up in the member pictures thread by the way.
Nov 17 2014 07:11 PM
de derde De BoerDon't worry, if you ever get court marshaled just ask to be represented by Lieutenant Kaffee. That guy is good, it will be your general getting dishonorably discharged,lol.
Nov 18 2014 11:46 AM
de derde De BoerAlways be yourself! Unless you can be batman then always be batman. lol.
Nov 16 2014 10:33 AM
Mrs Ashley PardewTune
Nov 18 2014 11:44 PM
apparently i bought and ate mcdonalds last night, well i woke up next to the remains.Nov 16 2014 12:11 AM
liverbird v04remains like the toy from the kids menu?
Nov 19 2014 08:49 AM
Santa HaRvYou woke up obese didn't you
Nov 19 2014 12:28 PM
Shinkansenyoure all sexy
Nov 21 2014 03:13 PM
So I know I upload alot of shit but if you wanna know what my life is like on a daily basis this is pretty much it. Also Butts. They are important. http://youtu.be/nY4R_fBAlYcNov 14 2014 12:10 AM
Pannaking 14
Hiddink needs to fuck off! Poor excuse of a coach! get rid of that greedy cunt now!Nov 12 2014 09:00 PM
Pannaking 14He did nothing else though, was poor like he has been for a very long time.
Nov 13 2014 10:08 AM
TsubasaShooting always was Sneijder's one and only quality.
Nov 13 2014 12:39 PM
Pannaking 14Nah his passing was amazing before he could spot things and played some great through balls. Now he just strolls around doing next to nothing.
Nov 13 2014 01:47 PM
I still consider 1999 as a recent year. Anyone born after that year that doesn't look like a toddler is weird to me.Nov 11 2014 08:30 AM
Mrs Ashley PardewNewcastle should have beat Man United at wembley, cunts
Nov 11 2014 11:37 PM
TrstntheGr1mIt still trips me out that people born in 1994 can be considered "adults" now :|
Nov 12 2014 11:07 PM
LeicesterBranThe year I was born.
Nov 13 2014 06:00 PM
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Any chance you could have turned the engine over backwards when installing it?
Type: Posts; User: DerekH
Any chance you could have turned the engine over backwards when installing it?
there was a recall for a fuel line on that side of the engine. could be that, i know the issue was that it was getting worn through and cars were catching on fire. so better be safe and get it...
ill trade you my stock head for the one that was on your test motor... ill even overnight it.
Ill chime in too, i have mine zip tied to the rad mount as well. no issues so far. 07 rabbit
I agree with everything said above, id like drop ins and i would probably spend the extra money on the higher quality pistons, however I'm not entirely sold on the idea yet. id like to see a before...
Are you still running stock injectors or have you upgraded to larger ones?
Sweet build, looks like someone sorted out the belt tensioner issue...
whats the build worth if you already have an sri and a header?
Congrats guys, great work. have you put this monster on a dyno? id love to see some charts though the build.
Thanks Fred, the tune is great very happy with it. super smooth and very fun to rev out. it was absolutely worth it.
Finally got my car tuned.
Thanks goes to Jeff and Fred the tune is amazing, and Edmund for organizing the local group buy. You guys rock!
IE SRI + UM tune = A lot of fun!
Thanks Fred, can't wait!
Bump, still need snows.
Don't forget me, i have the friday night 2130 for a 2007 rabbit IE sri tune.
Title says it all. Must be H rated or higher and in good shape, no plugs etc. please pm me with price and tire specs.
i was able to barely make it work with the stock studs and the half height bolt that came with the header. this was like 4 years ago now so i have no idea what size they were. i believe there was a...
i believe eventually there was a version with recessed bolt holes but i don't know which one that was or if it is even fact or just misinformation that has been passed around. i can say for sure...
the thickness of the flange makes it so the studs aren't long enough.
Any pics of it installed? id like to see how it looks installed before i preorder. is it going to work with aftermarket intake manifolds?
I agree, liqui-moly makes the engine run much quieter.
this sounds like the same symptoms i had when my crank sensor went.


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Videos tagged "See Canyon Fruit Ranch"
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Ceremony and Reception at See Canyon Fruit Ranch, San Luis Obispo.+ More details
Katherine & Steve's Wedding Video Preview10:16
362 Plays / 1 Likes / 1 Comment
Katherine & Steve's Wedding Video Preview June 15th, 2013 See Canyon Fruit Ranch Videography: JCV Productions www.centralcoastvideography.com+ More details
Married 8.25.12 in San Luis Obispo, CA. Song is "This Is Not The End" by Gungor and I do not own licensing to this track.+ More details
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Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."


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Measurements Of Famous Women
Last week we showed you the bra sizes of the most famous women in the world. We recognized your thirst and know you want more! So we did some more digging and found full measurements! So you'll know who's a brick house and who's just faking the funk.
Let's take a look!
(And remember, these are all "reported"…we haven't gotten the measuring tape out and done it ourselves…though we wish we could have.)
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Put On Blast: A Gallery Of "Creative Ideas" Beyonce Has Been Accused Of Stealing From Others


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News/Stories Results by Google: Undertaker 20 0
|Publisher: ProWrestling.net
|Sat, 22 Nov 2014 10:22:30 -0800
At 6:20, Morrison distracted Shad, which enabled Miz to hit the Reality Check to score another pin. At 8:30 ... Undertaker video recapped their feud... 3. ... Moments later, Punk hit the high knee and followed up with GTS on Regal and then pinned him ... read full story
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|Wed, 19 Nov 2014 07:22:30 -0800
20 years ago today in Cherry Hill, New Jersey, Chris Candido defated Tracy Smothers in the finals of a one-night tournament to win the vacated NWA World Heavyweight Championship. Candido was the first NWA world champion since Shane Douglas threw ... read full story
|Publisher: Crave Online
|Wed, 05 Nov 2014 06:48:45 -0800
... The Undertaker signaled for his finisher. But at that moment, the lights went out, organ music hit, and Kane would make his debut as he ripped the door off the cell and proceeded to hit Undertaker with the Tombstone Piledriver. ... Both performers ... read full story
|Publisher: Bleacher Report
|Tue, 02 Aug 2011 20:26:43 -0700
Still, the excitement and anticipation for The Undertakers's 20th Wrestlemania match may the biggest thing in wrestling besides The Rock's return to face John Cena at the same event. With that being said, this Wrestlemania is going to be mind-blowing. read full story


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My wife picked up a 3night stay for 150 total but we had to attend the sales pitch. Overall the resort is nice but not the best I've been to and we have been to many. The staff are friendly. 10am check out is ridiculous. Food was ok. Place felt empty even on thanksgiving day so I'm not sure why... More
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Rays close to adding J.P. Howell to league's best bullpen
May 9, 2011, 10:15 AM EST
Despite losing closer Rafael Soriano and setup men Joaquin Benoit, Grant Balfour, and Dan Wheeler to free agency the Rays' bullpen leads the league with a 2.82 ERA and they're close to adding left-hander J.P. Howell to the relief mix.
After struggling as a starter Howell moved to the bullpen full time in 2008 and went 13-6 with 20 saves, 171 strikeouts, and a 2.48 ERA in 156 innings over the next two seasons, but he missed all of last season following shoulder surgery.
Howell threw a scoreless inning at Triple-A over the weekend and manager Joe Maddon told Rick Stroud of the St. Petersburg Times that he's on schedule to rejoin the Rays around May 15.
Before that happens he'll need to show that he can work back-to-back games and Howell's fastball clocked in at just 84-86 miles per hour during the rehab appearance, but even when he was dominating in 2008 and 2009 his average fastball was just 86 mph.
- Chris K - May 9, 2011 at 1:37 PM
They're trading Howell to the Blue Jays?
- buddaley - May 9, 2011 at 3:55 PM
Rick Stroud writes for the St. Petersburg Times, not the Tampa Tribune. The comment about Howell appeared in the Times today.
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6-9am: Duke Meyer
6:20am – Vinyl Lust – a song from a real live LP
8:50am – The Buzz – music news of the day
9am-12pm: John Timmons
11:40am – The Buzz – music news of the day
12pm-3pm: Kyle Meredith
3-6pm – Matt Anthony
4:40pm – The Buzz
5pm – The 5'O Clock Shadow – an original followed by a cover tune.
6-8pm: World Café With David Dye
German electronic-reggae duo, Milky Chance gives insight into their musical background and the internet success of their single "Stolen Dance".
8pm-9pm: Connections Made by Guitar Center With Nic Harcourt
Listen for buzzworthy emerging and undiscovered talent chosen by one of music's most respected tastemakers!
9pm-1am – FPK's Afterdark with Sean Cannon
9pm – The Weekly Feed Preview – a song making waves across the internet.
11pm – On the Scene – We spotlight a music scene and feature two bands from the city
1am-2am: Night Visions With the OK Deejays and Sam Sneed
An eclectic mix of independent and under-represented dance, electronica, rock and pop music from around the world.
2am-5am: WFPK Overnight
Hear your favorite mix of FPK tunes all night long.


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A place for Percy Jackson and the Olympians fans to roleplay.
percy, jackson, demigod, camp, half, blood, forumotion, olympus, forum, fanfiction, site
The place to post ponies and feel welcome.
little, pony, friendship, magic, forums, rainbow, dash, fluttershy, twilight, sparkle, applejack, rarity, pinkie
A place where all types of gamers can unite and have a healthy dose of debates.
free, forum, generation7, gaming, types, gamers, unite, have, healthy, dose, debates, g7gaming, microsoft, games, sony, computer, entertainment, xbox, playstation
Free forum : A place to discuss the happenings going on and around the Pensacola FL area as well as the rest of the nation/world. Due to spamming by Guests, it is now a requirement to register to view messages.
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Chess2U is a place to discuss and share anything related to Computer Chess! So you will need Chess2U to keep up with Chess progress!
computer, chess, engines, opening, books, free, engine, software, download, best, news
Free forum : Discuss bets, tips and general chat regarding gambling.
punters, place, punt, chat, gamble, gambling, betting, punting, winning, chatting, funny, tipping, odds, banter
This is a non canon fairy tail rp site that takes place 50-100 years after the canon events. Create your own character, your own unique magic and much, much more.
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Feral Nature : A place where those who identify as Otherkin, Therian, or any assortment of non-human beings can come together.
otherkin, feral, nature, therian, dragon, therianthropy, furry, nonhuman
Free forum : A place to TRULY discuss watches openly and freely!
Free forum : A fun place to meet other young writers, find writing prompts, and share your story!
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Gathering place for those willing to run on the Darkside.
darksider, tire, motorcycle, 1800, 1300, honda, suzuki, yamaha, kawasaki, goldwing, valkyrie, daniel, meyer
Free forum : A place for CU Designers to share and CU Hunters to snag CU Freebies
free, forum, freebies, only, commercial, place, designers, share, hunters, snag, scrapbook, blogger, graphics, tuts, photoshop, scripts, actions
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A place for the old Over 50 Horsenet friends and new friends interested in horses.


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Free 2 year old German Shepherd to a good home.
I have to move to a smaller place and can not take my friend with me. He is nurtured and is current on all vaccines. He may be a little aggressive toward people he doesn't know but after a few minutes, he will warm up and behave. He is also house trained. He needs someone ...
Nov 23 -
Akc Blue German Shepherd Puppies
*Now taking Deposits!!* Purebred AKC registered German Shepherd puppies available. They are rare Blue/tan and Blue/tan panda colored. I have 2 blue/tan Panda females, 1 blue/tan female and 4 blue/tan males Mom and dad have hip and elbow clearances. Both parents have ...
Nov 1 -
Akc German Shepherd pups
Akc German shepherd puppies, 2 Females +4 Males, blk/tan/red, German Bloodlines and Mother + Grandfather on premises, 26 Hip + Health guarantee, Vet checked before leaving....$1000 + call or email for more info updated 11/13/14
Oct 19 -
Akc Panda German Shepherd
AKC registered blue/tan panda German Shepherd. Johnny is 10 months old, house broken, crate trained, knows basic obedience and up to date on all vaccines. He is very friendly and outgoing. He loves all people and animals! Johnny has not been neutered yet but he can be if ...
Oct 17 -
( beautiful akc German shepherd for sale- 1 1/2 years old)
very good with children. know all her basic commands and more. need a nice yard to run. very good watch dog also. I am moving and can't take her with me
Oct 12 -
New Castle
( dewormed )
Nov 23 -
Baltimore :
Silver Spring
Akc female german shepherd , knows basic commands , great dog , loves children's , with pedigree !! Up to day on shots , get alongs with other dogs !! Reason for sale is my kids have asthma , they where in the hospital for 4 days !!
This ad was posted with the eBay ...
Nov 8 -
Baltimore :
Owings Mills
German Shepherd Dog - Captain - Large - Young - Male - Dog
Captain is a very handsome young man. He is outgoing, playful and somewhat vocal, but on the whole is polite and mannered. He is willing to work to please you and he is extremely friendly and very smart. He is a fun ...
Nov 1 -
Baltimore :
I have Pure breed AKC Geramn Shepherd pups Ready now (8 wks Oct 29th and born Spet 3). Sable or black and tan females. All vet checked, first shots, wormed and paperwork. Socialized with people,children and other pets. Parents have imported and champion bloodlines. Beautiful ...
Oct 30 -
Baltimore :
Bel Air
German Shepherd Dog - King - Large - Adult - Male - Dog
King is looking for a new family to love after his own family had to move. At 10 years of age, King is young at heart, and very energetic. He is good with children. Please consider making this sweet boy part of your ...
Oct 30 -
Atlantic City :
German Shepherd Dog - Trixie - Large - Senior - Female - Dog
Dearest Trixie lost her human to brain cancer. The family tried to keep her, but circumstances made it impossible. Knowing her for years before her loss...I know she is a good dog. She was an only dog her whole ...
Oct 25 -
Baltimore :
German Shepherd Dog - Oden - Large - Adult - Male - Dog
THIS IS A COURTESY POST. IF YOU ARE INTERESTED IN ODEN, PLEASE CONTACT KAITI AT 269-806-2184 OR AT [email removed] Oden, is approximately 4 years old, 90lbs, and may put on additional weight as his body gets use to ...
Oct 15 -
Baltimore :
14wk old male aca shepherd. Up to date with shots. Great with other dogs and kids. Not crate trained house broken. Weighed 35lbs at 12wks going to be a big boy.
Oct 13 -
Baltimore :
Akc german shepherd male , need to sell asap because my kids have asthma and I had my two daughter for 4 days in the hospital
This ad was posted with the eBay Classifieds mobile app.
Oct 12 -
Baltimore :
Owings Mills
German Shepherd Dog - Princess - Medium - Young - Female - Dog
Our little Princess is certainly a lovely and regal little girl. She is petite and dainty and loves affection! Princess unfortunately found herself in a shelter because of landlord restrictions, and it is very ...
Oct 11 -
Baltimore :
Akc german shepherd 2years and couple mont born in 5-13-12 with vaccine up to date , spend 750 on trained , very friendly , athletic good drive need to sell as soon as possible I have 5 dogs and is to much !! I will take 250 or best offer with papers and vaccine records !!
Oct 10 -
Baltimore :
Owings Mills
Akc german !! Good drive , athletic , know basically command sit down stay !! Born May 13 2012 he is a father and a really good dog really friendly , nice temper !! The reason I am selling is I have too many dogs so I want to cut back !! Any question call me 400$ obo !!i ...
Oct 4 -
Baltimore :
Owings Mills
I have a female akc german shepherd for sale she is 2 months old ready for a new home already vaccine and de wormed 500$ obo
This ad was posted with the eBay Classifieds mobile app.
Oct 3 -
Baltimore :
Owings Mills
Cocker Spaniel - Bebe In Pa - Medium - Adult - Female - Dog
PLEASE SEE MY PICTURES AT THE BOTTOM OF THIS PAGE! 11/18/2014--UPDATE FROM BEBE -Hi everyone! Bebe here checking in on you all! I am doing well! The holidays are coming, and things are busy in my foster home! I ...
Sep 28 -
Baltimore :
German Shepherd Dog - Piper - Medium - Baby - Female - Dog
Piper was neglected as a puppy. She was fearful of all people, was severely thin, full of worms and missing hair. We have had her in foster care, she is now 8 months old, she has grown and has learned to trust her ...
Sep 28 -
Baltimore :
German Shepherd Dog - Gaston - Large - Young - Male - Dog
You can fill out an adoption application online on our official website. It is quite apparent that Gaston has not been dealt many good hands in his short life. He has that hardscrabble look about him that is the ...
Sep 23 -
Baltimore :
White German Shepherd - Jada - Medium - Senior - Female - Dog
Beautiful and sweet White Shepherd/Yellow Lab mix girl! Meet Jada! Jada is a gem of a doggie. She is sweet, calm and loving. She is great with dogs and humans - gentle children, too. Our vet estimates that Jada ...
Sep 6 -
Baltimore :
German Shepherd Dog - Aviva - Large - Adult - Female - Dog
You can fill out an adoption application online on our official website.Aviva has come back to ASR and we are are working with veterinary specialists to determine how to help her attain a healthy weight and appetite ...
Aug 10 -
Baltimore :
German Shepherd Dog - Leila - Small - Baby - Female - Dog
You can fill out an adoption application online on our official website. Leila is sponsored by quite a few people! Check out her list here Leila is just the sweetest, most loving little girl! She smothers your face ...
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The Top 10 In Action Sports
01This British Council Is Trying To Make Skateboarding A Crime...
02Want To Escape The UK And Surf Every Day? This Is The Place To Go…
03Snowfall In New York Has Been So Deep, People Can't Get Out Of Their Houses
04What Do You Get If You Cross A Zip-Wire With A Roller Coaster?
0523 #FirstWorldProblems People Encounter When Skiing
067 Awkward Moments Every Brit Experiences When Surfing Abroad
07'Has Skiing Made Me Bald?' - What Do You Contemplate When You're On The Chairlift?
08This Squaw Valley Ski Edit Is Not To Be Missed...
09This 22 Year Old Student Took Three Years To Make This Adventure Film. The Result Is Truly Beautiful…
10From Small Photo To Breathtaking Reality: This Ski Trip Is One Of The Best We've Seen...
NESCAFÉ CHAMPS Leysin 2013 – Highlight Finals
A Snowboarding video by quattro_media - 1,087 views
America sweeps Woman's Podium, Finland's Janne Korpi prevents a route...
All but perfect conditions create all time riding conditions as 16-Year Old Ty Walker (USA) confirms her status as the Über rookie taking out the 22nd Edition of the NESCAFÉ CHAMPS building Slopestyle points for the 2013-14 season.
For more info and results visit: www.nescafe-champs.ch
What Do You Think?
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Tour of the Catechism #51 - Anointing of the Sick
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Uploaded by AirMaria on Aug 23, 2014
Paragraphs 1499 - 1532 - Part Two. The Celebration Of The Christian Mystery - - Section One. The Sacramental Economy - - -ĀChapter Two. The Sacraments Of Healing - - - -ĀArticle 5. The Anointing Of The Sick - - - - -ĀI. Its Foundations in the Economy of Salvation - - - - -ĀII. Who Receives and Who Administers This Sacrament? - - - - -ĀIII. How Is This Sacrament Celebrated? - - - - -ĀIV. The Effects of the Celebration of This Sacrament - - - - -ĀV. Viaticum, the Last Sacrament of the Christian - - - - -ĀIn Brief Ave Maria! "Tour of the Catechism of the Catholic Church" is given by Fr. Daniel J. Mahan, S.T.L., pastor of St. John the Apostle Catholic Church in Bloomington, Indiana, and St. Jude the Apostle in Spencer. He will cover the entire Catechism in about 80 videos, giving an outline of the content along with clear easy to follow explanations. It will be based on theĀ2nd Edition of the Catechism. To Download Audio go to http://airmaria.com?p=44502
Fr. Daniel Mahan Tour of the Catechism Anointing Of The Sick Catechism Catholic Church CCC Extreme
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IC Test Engineer - Nashua, NH
Location - Nashua, NH
I am trying to find a IC Test Engineer for Nashua or Cambridge.
Experience developing on a variety of automated test equipment (ATE). Examples include LTX/Credence ASL, LTX X-series, Teradyne FLEX, micro-FLEX, ultra-FLEX, or Eagle ETS-364 / ETS-88 ...
Nov 23 -
Nashua - Arch & engineering
Licensed Practical Nurse | LPN | GERI (Per Diem)
For details and to apply, please visit
Job Title: Licensed Practical Nurse | LPN | GERI (Per Diem)
Company Name: Favorite Healthcare Staffing
Location: Boscawen, New Hampshire
Job Type: Part-Time/Full-Time
Profession: ...
Nov 22 -
Concord - Medical & healthcare
Business Development
The Spencer Thomas Group is hiring - No Experience Required .We train the right Team Members. We're seeking dynamic, energetic and passionate people who will bring a balance of creativity, focus and determination to our team.Bring your DesireYour passion to learn Your out ...
Nov 22 -
Portsmouth - Everything else
CNC Programmer -- M and G Code programs
Fantastic opportunity for a great company in a fantastic location.Our client is a world class manufacturing company, with an advanced manufacturing team in Hanover New Hampshire. Due to the growth of the business, there is an immediate need to ad a top notch CNC Programmer ...
Nov 22 -
Hanover - Everything else
Reg Truck Driver-Home Wknds-$825 Wk Guant./Avg Over $1000 a WK-M
Regional Truck Driver
Home weekly
Home on weekends with 48 hour reset
$825 a week guaranteed
Average over $1,000 a week
95 % no touch freight and 50 % drop and hook
We go as far west at Texas in Dallas and Houston and as far south as Atlanta. We also run a lot into the ...
Nov 22 -
Nashua - Transportation
Nov 22 -
Manchester - Transportation
Nov 22 -
Concord - Transportation
Field Service Technician
A regional distributor of CNC machine tools, tooling and accessories, and related engineering and support services, is seeking an ambitious and conscientious Field Service Technician for our Newport/Manchester, NH territory. This role will provide exciting opportunities to ...
Nov 22 -
Newport - Everything else
Manufacturing Manager
We are on the lookout for a driven individual with a passion for the biopharmaceutical industry. One of our clients is looking to add a strong Manufacturing Manager to their team:

1) Plan, organize, staff, direct and control production of company's immunoassay ...
Nov 21 -
Concord - Everything else
Front Office Receptionist/Estimator/Pricing
Receptionist/EstimatorA local leading organization in Salem, NH is currently seeking an experienced Receptionist/Estimator. This is a great opportunity for recent Graduates from Technical School with an interest in estimating, project coordination and technical ability.• ...
Nov 21 -
Salem - Everything else
Tellers- Portsmouth
In partnership with a local credit union, Adecco is recruiting for several new Teller jobs on the Seacoast! Qualified Teller candidates will possess prior teller experience working as a Teller. Strong customer service, good math and sales aptitude and ability. Candidates ...
Nov 21 -
Portsmouth - Everything else
Adecco is currently assisting Sig Sauer in recruiting for a Driving position. This position is 1st shift and runs Monday through Friday, 7:00am to 3:30pm.The Driver position is responsible for the transportation of parts daily from Portsmouth, NH to Portland, ME. ...
Outside Sales-Looking for Seasoned Merchant Services Professionals
Merchant Business Alliance is actively seeking outside sales partners to market our merchant services and business solutions to independent business owners. Your main responsibility is showing merchants how they can accept credit cards at a significant savings while helping ...
Nov 21 -
Manchester - Sales & biz dev
Medical Surgical With Telemetry Registered Nurse
Cross Country TravCorps has more of the travel nursing jobs that you want. We currently have an opportunity in Lebanon, NH for a Medical Surgical With Telemetry Travel Nurse, however if this position isn't right for you... don't worry about it. We have new and exciting ...
Nov 21 -
Lebanon - Medical & healthcare
In Home Sales/Construction Sales - LOWES - Nashua
The Project Specialist - Exteriors (PSE) is a salary plus commission in-home sales position. The PS-E plays the primary, customer-facing role, meeting with customers in their homes, assessing their needs, measuring, conducting a professional sales presentation, preparing a ...
Nov 21 -
Nashua - Sales & biz dev
Independent Sales Representative
Innovative medical specialty distributorship with unique, enabling technologies seeks an independent (1099) medical sales representative for the North Boston/Maine/New Hampshire territory. Candidate must have proven sales track record and be self motivated. Your success ...
Internal Medicine Nurse Practitioner (40 miles from Keene, NH)
Busy outpatient internal medicine practice is in need of a full time Nurse Practitioner with previous clinical experience.
Monday - Friday 8 - 5, with one day per week 9 - 6. Outpatient call; 1 - 4 or 5 with rotation to include weekend coverage.
Busy office is located on ...
Nov 21 -
Keene - Medical & healthcare
Senior Web Applications Developer (NH/MA Border): $100k+
Accessible to Rt3 and I-495, our offices are located near the NH/Mass border. We're seeking a passionate Web Developer to join our growing team. The ideal candidate comes with comprehensive web development expertise, strong client-side (JavaScript, AJAX, & jQuery) skills, ...
Nov 21 -
Nashua - Graphic & web design
Technology Sales Specialist
Technology Sales Specialist
MarketSource is currently looking for exceptional individuals to fill a permanent part-time position in assisted sales. This Technology Sales Specialist position requires a solid understanding of consumer electronics and the ability to sell ...
Nov 21 -
Newington - Retail & wholesale
ER Travel Nurse Job in Concord New Hampshire
Concord New Hampshire has a need for an Emergency Room Travel RN. This is a large facility with a Trauma 1 Emergency room. Immediate opening for an experienced Emergency Room Registered Nurse in a New Hampshire ER for 13 week contract, guaranteed Hours- top pay. ...
Brand Ambassador for Dog Food Demos
Do you love dogs? Do you have event demoing experience? This may be the perfect opportunity for you! Work in a pet-friendly environment representing a premium line of dog food to customers who really care about their dogs.
This is an ongoing independent contractor event, ...
Nov 21 -
Nashua - Marketing & PR
ICU Nurse
Job Title: ICU Nurse
Position Summary:
Responsible for the delivery of patient care through the nursing process of assessment, diagnosis, planning, implementation and evaluation. Responsible for directing, coordinating all nursing care based on established clinical nursing ...
Nov 21 -
Portsmouth - Medical & healthcare
Wax Injector 3rd Shift-Benefits-Overtime!
Perform somewhat diversified duties requiring average skill and ability to produce a wide variety of moderately large and difficult wax patterns. Perform wax repair to patterns, as required.
Work with moderately ...
Nov 21 -
Tilton - Construction & trades
Foundry Melt Caster-Overtime-Bonus-Benefits
Perform somewhat diversified duties to assist in the melting and casting of molds following established methods and procedures.
Assist Caster A in all phases of foundry solid and shell mold operations, such as positioning molds for ...
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Ya cause I just checked twitter and I didn't see any post like that.
To reiterate what has already been posted:
"Beginning June 11 @ 11pm EST/ 8pm PST, the Samsung Galaxy S II will have an optional software update to Android version 4.0.3 / Software T989UVLE1 via Kies. This update changes the Android OS to Ice Cream Sandwich (ICS)"
The important thing however is, I just saved a ton of money on my car insurance.
Forget about it read the doc it'll be available a 11pm est today! ****, i didn't sleep last night waiting for the freaking update!
i mean honestly. Not sleeping because of an OS update for your phone. I am excited for the update but really? You need to reevalute life.
i feel like brian the dog from famliy guy when stewie would not let brian down the stairs lol.
Yo just look on my twiter cbrbikerf4 its all there
I wiilll just go with 11 pm timeline..
You are joking about bring up all night waiting for an upgrade. If you go to Android Central forum then the T-mobile Galaxy S2 forum. There is one or two posts about getting ICS and it giving them problems.
I actually think it is the latest update that was rolled out over the past couple of weeks they are talking about.
I finally got my phone working right after that one. Two factory resets and battery pulls. No more echo on calls and my wifi is operating again.
There are some posts over there also about that. Don't know if you really want to be the first on the block with the ICS update. I would, and am going to wait at least two weeks before I try it.
I cant afford having my phone messing up right now.
I wonder why 11pm? If the update is ready why not roll it out? They should wait until 11:59pm; still would be June 11th.
tmonews just took down the post that the ics update was ready, lol
LOL! They jumped the gun just a bit.
haha they just fixed it to 11 pm
David Alire: when is ics coming out for galaxy s 2
%Rey-ann G: Welcome to T-mobile live chat. I'm Rey and My ID# is 853245. Let me try to check that update for you. Please give me a moment.
%Rey-ann G: Currently, there's an ongoing software update Gingerbread in preparation for the upcoming Ice Cream Sandwich (ICS) update.
%Rey-ann G: We don't have updates for ICS yet.
%Rey-ann G: Is there anything else?
David Alire: you dont have ics updates yet. man your guys twitter and facebook lie. its supposed to be today
%Rey-ann G: I'm sorry about that. T-mobile will send ICS over the air if ever we have the update. We still don't have new from the management.
%Rey-ann G: We still don't have news from the management*.
%Rey-ann G: Is there something else?
David Alire: nope thats it.
%Rey-ann G: Thank you for choosing T-mobile Live Chat. have a good one.
%Rey-ann G: I'll go ahead and close the chat in 60 seconds if you haven't disconnected it by then.
Retrieving data ...


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Dr. Paul Hershenson, MD
Internal Medicine, Paul Hershenson MD PC
- 170 Maple Ave Ste 202
White Plains, NY 10601
- 1 Office Location
- (914) 682-0464
Dr. Paul Hershenson has been practicing medicine for 56 years. Dr. Hershenson graduated from the Rosalind Franklin University/ Chicago Medical School in 1958. He practices medicine in White Plains, NY and specializes in Internal Medicine and Pulmonary Disease. Dr. Hershenson is affiliated with White Plains Hospital. He speaks English and Spanish.
Gender: Male
Years in Practice: 56 Years
Languages Spoken: English, Spanish
Medical School: Rosalind Franklin University/ Chicago Medical School
Graduation Date: 1958
Hospital Affiliations: White Plains Hospital
Specialties: Internal Medicine, Pulmonary Disease


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Eclectica Vintage 1980s Kenneth J Lane Large Resin Cluster Clip-On Earrings, Turquoise / Coral
Product informationA bold pair of clip-on earrings from Kenneth J Lane, designed in the 1980s. In chrome plated fittings, with a fearlessly vivid cluster of blue and coral resin and glass details.
- Brand
Eclectica Vintage
- Dimensions
- W2.5 x H4cm
- Earrings Fitting
- Clip-On
- Jewellery Type
- Earrings
- Main Stone Type
- Resin
- Material
- Chrome plated
Delivery in 7 days from our supplier
- Free
International delivery not available
We want you to be happy with your purchase. If you're not, depending on the type of product, you can make free returns in the UK via John Lewis shops, Royal Mail, Collect+, or MyHermes. If you need to arrange collection of large or heavy items, call us on 03456 049 049. For international returns queries, call us on +44 1698 545 454. Find out more about returns.
You'll find returns information on your delivery note. Unless faulty, we'd like you to make your return within 90 days of purchase. Exceptions apply to certain products - find out more about our refund policy.


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Losing with dignity - Music Videos
Embed speakmyword 638 views 2013-01-24T21:54:10 The Daily Pulse (Friday, January 25, 2013): But as for you, continue in what you have learned and have become convinced of, because you know those from whom you learned it... 2 Timothy 3:14 (NIV)
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How Boca Raton became the region's technology hot spot
Fast Tech Awards
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On this year's list of the Top 15 fastest-growing technology companies, nine of the firms are based in Boca Raton. To some, it might seem peculiar that a city of about 90,000 has earned such tech power in a region of 5.7 million.
To those familiar with the city, its history and its technological underpinnings, peculiar doesn't enter the equation.
Boca Raton exists at the intersection of location and circumstance. One could argue Henry Flagler's railroad introduced technology to the region. Some would say tech's first real infusion came with the U.S. Air Force radar installation during World War II. That was followed in the 1960s when IBM's research and development team arrived – ultimately delivering the personal computer in the 1980s.
"Boca has a long history of innovation," said Keith O'Donnell, a partner with commercial real estate firm Avison Young.
When IBM later shrank its ranks, thousands of technology workers who lived here decided to innovate anew. They spawned companies such as Citrix Systems and a host of other technology firms.
The realities of modern innovation and tech development also helped the region flourish and attract top talent, said Andrew Duffell, president/CEO with the Research Park at Florida Atlantic University. The park is home to a dozen tech firms and startups, including Modernizing Medicine, Mobile Help and Pace – three leading regional technology companies.
In a community the size of Boca Raton, "the makeup of its current business community means the impact that these technology companies have stands out more, and their successes are celebrated more visibly," Duffell said.
Jeff Zbar writes for the Business Journal's special reports, including awards sections.
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mirabelleSyllabification: mir·a·belle
Pronunciation: /ˈmirəˌbel /
Definition of mirabelle in English:
1A sweet yellow plumlike fruit that is a variety of the greengage.
Example sentences
- The mirabelles, which are another group of mainly yellow plums, are also hard to classify with confidence but placed by some authorities as varieties of P. insititia.
- It smells racy, intense and richly baroque, glittering with aromas of apricots, nectarines and mirabelles.
- That's when we saw a section which had first escaped our attention, the pick-your-own plum trees - dozens upon dozens of beautiful leafy trees, positively laden with quetsches and mirabelles.
early 18th century: from French.
Definition of mirabelle in:
- British & World English dictionary
- Spanish dictionary
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Word of the day Sprachgefühl
Pronunciation: ˈʃprɑːxɡəˌfuːl
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21 years of experience
Video profile
Accepting new patients
21 years of experience
Video profile
Accepting new patients
4870 York Rd
Buckingham, PA 18912 Phone number & directions
Buckingham, PA 18912 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
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Specialties & Research
Dr. Simona Walsh, MD is board certified in Pediatrics.
Education & Awards
Dr. Walsh graduated from Universitatea De Medicina Si Farmacie Iuliu Hatieganu, Cluj Napoca.
Dr. Walsh has 1 hospital affiliations:
- Doylestown Hospital
- French
- Romanian
Home > Find a Pediatrician > PA > Buckingham Pediatricians > Dr. Simona Walsh, MD
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- Additional Information
- Dr. Simona Manuela Walsh MD is a female Pediatrician, has 21 years of experience and practices in Pediatrics.
- Where does Dr. Simona M. Walsh practice?
- Dr. Simona Walsh has 1 office location.
Dr. Simona Walsh practices Pediatrics near Buckingham, PA.
See Buckingham Pediatricians.