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Google, Apple, Microsoft: Will 2014 be the year the auto tech war heats up?
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- Lauren Hepler
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Consumers are juggling increasing numbers of electronic devices — from smartphones and tablets to wearables like Google Glass — and automakers are trying to figure out how to best link all the technology while minimizing distractions.
Now that virtually every major automaker has an R&D presence in Silicon Valley to aid in this pursuit, look for competition to upgrade in-car operating systems to accelerate in the year ahead.
This week, Google upped the ante in the evolving field with the announcement of an Open Automotive Alliance to create an in-car version of the Android operating system. General Motors, Honda, Hyundai and Audi have all signed on to the Google project, begging the question of how competitors like Apple Inc. and Microsoft Corp. will respond.
"You'll see more announcements like this. There's a lot left to figure out," said Gary Silberg, the Chicago-based national automotive industry leader for KPMG. "Google's competitors will react."
If tech companies — Google or otherwise — are successful in their bid to gain a bigger role in the car market, the play could lead to new revenue and push automakers to compete for bells and whistles. Silberg is also watching for auto tech "concept convergence," where advances in fields like sensor-based technology lead to new breakthroughs for in-car entertainment and self-driving cars alike.
As we previously reported, companies like Mercedes-Benz already allow drivers to access music, contacts and social media accounts in their cars through smartphone plug-ins. The new Google initiative, while still scarce on details, generally aims to improve the software running inside a car and help developers tailor apps for in-car use.
Lauren Hepler is the economic development reporter at the Silicon Valley Business Journal.
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Nathan Beaulieu won the Memorial Cup with the Saint John Sea Dogs this season. (Photo by Nick Laham/Getty Images)
2011-06-25 11:55:00
The Montreal Canadiens took Nathan Beaulieu with the 17th overall selection in the NHL draft.
Beaulieu enjoyed success with the Memorial Cup champion Saint John Sea Dogs this season and improved as the year went along, finishing with 45 points in 65 games and adding 17 points in 19 games during the Quebec League playoffs.
After being selected by the bleu, blanc et rouge, the skilled, offensive defenseman talked to the media.
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Home > Sport > Golf
Sunday February 9, 2014 MYT 5:38:00 PM
Sunday February 9, 2014 MYT 10:06:37 PM
by rajes paul
Danny Chia in a file photo. After six months of rehab, Danny is eager to get fit in time for the Maybank Malaysian Open.
KUALA LUMPUR: A six-month layoff from the sport has whetted the appetite of professional golfer Danny Chia to make a swinging return to his favourite tournament – the Maybank Malaysian Open from April 17-20 at the Kuala Lumpur Golf and Country Club.
The 41-year-old Danny is slowly returning to competitive tournament after undergoing surgery for a career-threatening shoulder injury last September.
"I had been suffering from the stiff neck and shoulder problem for three years but I somehow managed to play on," said Danny.
"But last year I couldn't bear the pain anymore. I couldn't even lift my arm ... so, I went for an MRI (magnetic resonance imaging) scan. Based on the report, I knew I had to go for surgery if I wanted to save my career."
Danny, who is the only Malaysian to have played in all four rounds of the British Open in 2010, said that his mission now is to be fit – physically and mentally – for the home tournament, which he has been a regular of for more than a decade.
Danny has always been considered the best local golfer and someone who has a chance of becoming the country's first home champion, although he has allowed pressure to get to him on many occasions.
Despite the struggle to live up to expectations, Danny has always looked forward to the Malaysian Open – and it's no different this time.
"The six months that I was out were tough, especially for a guy like me ... who used to travel so much for tournaments. I missed golf a lot," said Danny.
"I did nothing much except spend more time on rehab. I worked on regaining the lost muscles in my right arm. It was a long and tedious process but I'm glad to be back on the course now."
So eager was Danny to return to the greens that he took a shorter time than many to get back on his feet.
He has already taken part in two local tournaments this year – the Sabah Masters and the I&P Tournament of Champions.
And, according to him, everything is going as planned.
"I'm at the stage where I'm re-building my game and trying to get back the feel of playing in tournaments. I didn't do that well in the last two local tournaments but they did give me some indication of where I stand.
"It's too early to make any conclusions on how far I can go but it's certainly a good step forward. I hope to be ready for the Malaysian Open, though," said Danny, who is the first Malaysian to have won on the Asian Tour, a feat he achieved in 2002 at the Taiwan Open.
His next tournament is the second leg of the PGM Tour – the Swiss-Garden Closed Championship at the Damai Laut Golf and Country Club in Lumut, Perak, from Feb 12-15.
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Another Computer Legend Passes Into the History Books
Computer scientist Dennis Ritchie, who drove the design of the C programming language and the UNIX operating system, died over the weekend at the age of 70. While not a household name, Ritchie, along with cohorts Ken Thompson and Brian Kernighan, helped create the foundation for much of modern computing.
Ritchie is perhaps best known as the co-author of the book, The C Programming Language, which became the bible to C programmers ever since its publication in 1978. Kernighan, who co-authored the book, attributed Ritchie with the design of the language though.
While many criticized the admittedly dangerous features of C (dangling pointers, unbounded array copies, promiscuous data type casting, and so on), it became popular in part because it was a no-holds-barred type of language, and allowed the programmer free reign to pursue all sorts of mischief — both good and bad. That reflected the US software culture of the times.
While UNIX and (especially) C are still prevalent in the current computing landscape, they are not nearly as dominant as they were in the last two decades of the 20th century. But the next generation of languages and operating systems, C++ and Linux in particular, have direct lineage back to those foundational technologies.
Even other languages, whether they resemble C syntax or not, usually come with C bindings so they can tap into the rich set libraries developed over the last three decades. Today, it's hard to imagine a software stack in the computing industry without C and UNIX and the technologies they spawned.
Both C and UNIX also benefitted from being born at the right time. It was in the late 70s and early 80s that marked the rise of the enterprise server build-out (not to mention the PC market). Importantly, these technologies enabled an open systems model for the industry. The UNIX OS was the first major open source software project, which led to its adoption at universities and research centers.
Ritchie regarded C and UNIX as historical accidents though. From his perspective, the world was just ready to embrace these technologies because of their ease of distribution and openness. "Somehow both hit sweet spots," he said, in an interview with ITworld back in 2000. "The longevity is a bit remarkable."
The open nature of the software enabled companies like IBM, HP, Sun Microsystems, and other OEMs to build platforms in which applications could be compiled with C and run on various UNIX OS flavors (HP-UX, IBM AIX, Sun Solaris) more or less unmodified. I say more or less because in truth, these commercial UNIX variants parted ways that often made it difficult to pass applications freely from one vendor's system to another. With the emergence of Linux, UNIX's open source offspring, the technology became more standardized, and in the process, even more widely disseminated.
For all of Ritchie's influence on the industry, he never really became a pop icon in the manner of Steve Jobs or Bill Gates. Unlike Jobs and Gates, who led their respective companies to fame and fortune, Ritchie was the archetype computer scientist — the guy that came up with all the great ideas, upon which others built great empires.
To programmers of his time though, he was a hero. A Harvard grad, with majors in physics and applied math, Ritchie was one of the best and the brightest of the new breed of computer geeks making their way into the world of the late 60s. It was in 1969, while working at AT&T, that he, along with fellow colleagues Ken Thompson, Brian Kernighan, Douglas McIlroy, and Joe Ossana developed the UNIX operating system.
In 1983 he received the Turing Award. Five years later, he was elected into the National Academy of Engineering for the development the C language and for co-developing UNIX. He was subsequently awarded the National Medal of Technology in 1998. In January of 2011, Ritchie, along with Ken Thompson, were awarded the Japan Prize for Information and Communications for their UNIX work.
Despite these accolades, Ritchie remained humble. For would-be language inventors he had this advice:
"Don't have any expectations that anyone will use it, unless you hook up with some sort of organization in a position to push it hard. It's a lottery, and some can buy a lot of the tickets. There are plenty of beautiful languages (more beautiful than C) that didn't catch on. But someone does win the lottery, and doing a language at least teaches you something."
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Special to the Chickasaw Journal HOUSTON – The Houston Band Boosters will host their annual fish fry fundraiser on March 8 and is asking the community to purchase their tickets as soon as possible. The Friday night event will see Seafood Junction once again cook up to-go plates at Houston Middle School from 4 […]
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Israel's comatose ex-leader Sharon shows signs of consciousness
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By Allyn Fisher-Ilan | January 28, 2013 8:42 AM EST
Seven years after suffering a massive stroke comatose ex- Israeli prime minister Ariel Sharon has surprised his doctors by displaying "a certain degree of consciousness," an expert who examined him using an MRI scan said on Sunday.
The results of tests conducted by a joint Israeli-American team did not mean the former general and right-wing politician turned peacemaker was about to wake up from the coma he has been in since a January 2006 stroke.
But doctors saw the responses displayed by Sharon, 84, in a two-hour exam on Thursday as "encouraging" that there may some day be a cure for some comas, Alon Friedman, a neurological director at Israel's Soroka Medical Centre in Beersheba, said.
Experts at Soroka, joined by a leading U.S. neurologist, Martin Monti, of the University of California Los Angeles, scanned Sharon's brain to test its function Friedman told Reuters in an interview by telephone.
"The chances of him getting out of bed are very, very slim," Friedman said.
But the machine detected some brain activity, when Sharon was shown photographs of his family and also when asked to imagine his home, he said.
These findings suggest that despite Sharon's comatose state "he might be listening, and some important information goes into his brain and is being processed," Friedman said.
Sharon "might be awake, and there is a chance that he is conscious," though due to paralysis suffered as a result of his stroke he cannot respond physically, he added.
"To some extent the patient is what we call 'locked in', he understands and responds with his brain but cannot activate any muscles."
Friedman said Sharon's eyes were open for at least part of the time when he responded to the sight of family photographs.
More surprising were signs the machine showed that Sharon had processed a request to imagine various scenes such as his home, Friedman said, adding that Sharon's brain had also shown signs of responding to his son, Gilad's voice.
"The results of the tests are not clear but encouraging, and they surprised us," Friedman said, adding he saw the results as contributing to data about potential stimuli scientists hope may someday help them awaken certain patients from a coma.
"This is futuristic, and not the case at the moment," he said.
Sharon's stroke felled him at a critical juncture in Israeli politics.
Once a hard-line defence chief, Sharon made a dramatic political about-face with a 2005 Gaza pullout. His illness came just weeks after he made a dramatic exit from the right-wing Likud party to found a centrist faction in the hope of advancing peace moves with the Palestinians.
(Writing by Allyn Fisher-Ilan; Editing by Jason Webb)
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Alan Haselhurst
MP, Saffron Walden
MP, Saffron Walden
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Alan Haselhurst hardly ever rebelled against their party in this parliament
Connoisseurs of parliamentary proceedings may find it wry that I have the honour to serve under your chairmanship, Mr Chope. I hope your mind is cleansed of those occasions when the roles were reversed and I may have had occasion to call you to order. I thank my hon. Friend the Member for Harlow (Robert Halfon) for giving us this opportunity to raise these issues—issues that I imagine...
That was not exactly how it was explained to me by the police officer who came to the discussions at Hatfield Heath; but what my hon. Friend says demonstrates my point. There is uncertainty about what must happen. If the law is being applied unevenly because police discretion means variation from one place to another, that is not helpful to any of us. To sum up, what we need and what the...
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Conservative MP for Saffron Walden
Entered House of Commons on 18 June 1970 — General election
Changed party from Conservative on 16 May 2005
Also represented Middleton and Prestwich
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Sales of Cumbria's police buildings raise more than £1.7m
Last updated at 13:09, Monday, 25 August 2014
More than £1.7 million has been raised so far from a sale of police stations and buildings in Cumbria.
Documents have revealed the sums paid out to date in the big sell-off, which was launched to slash costs in the wake of budget cuts. A report also reveals the status of a number of properties that are still waiting to be sold.
The sale was launched more than two years ago following a review of all force stations, offices and buildings to see if they provided value for money and met the needs of communities and local squads.
Stations in Wigton, Cockermouth, Keswick, Maryport, Cleator Moor, Egremont and Alston were among those chosen to be sold.
Figures gathered for the county's crime commissioner, Richard Rhodes, show a total of £1,771,100 has been paid for properties so far. The highest individual sum was £327,000 following the sale of Keswick police station. Pub chain JD Wetherspoon is opening a bar on the site. The lowest was £45,600 for Millom Police Station.
A report to Mr Rhodes' executive board, which includes police chiefs, states: "There were originally four properties that were planned for disposal in 2014/15."
It says the former Wigton Police Station is due to be marketed soon, while a rental agreement has been extended with the current occupiers of what used to be Cleator Moor Police Station. On Maryport Police Station, the report adds moves on this property are "currently on hold pending decisions regarding operational requirements".
Police are no longer based at any of these sites.
"It is now unlikely that a sale will be achieved during 2014/15," the report states about the Maryport station.
The other property involved in this year's plans is a police house in Ambleside. It was said at the time of the shake-up that it would save about £119,000 a year in running costs.
Some community leaders voiced their disappointment but the force said it was a "small number of buildings" that were "under-occupied and under-used".
Officers said the way people used stations had changed and visitor numbers were in decline, while technology allowed police to do more while out and about. Cash raised is being used for a new station in the south of the county.
First published at 13:05, Monday, 25 August 2014
Published by http://www.newsandstar.co.uk
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RSA adds Big Data analytics to security service suite
In just under a month, security folks are coming to San Francisco for the annual RSA show, and if Wednesday's announcement from the company is to go by, one of the major themes at conference will be Big Data. At a press conference at its Massachusetts headquarters, RSA unveiled its Security Analytics appliance that's designed to …
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All pitching for that GCHQ contract?
Perhaps they should outline their new improve private key management software?
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New Century FS 1017 Ogan Ave P.O. Box 781 Grinnell, IA 50112 Phone # 641-236-3117 Fax # 641-236-5363
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Any Latina and LJ
October 30, 2014 − Amy Latina, LJ
Amy Latina and LJ now have their leather jackets on and these two sexy girls just cannot get enough of touching each other.
Sapphire Storm
October 28, 2014 − Sapphire Storm
Gorgeous Sapphire Storm is a secretary everyone would like in their office as she looks stunning in the satin blouse, mini-skirt and fishnet tights, the boots are a very sexy look too.
Sapphire Storm
October 26, 2014 − Sapphire Storm
Sapphire Storm looks very sexy dressed as a secretary in a satin blouse, leather mini-skirt and fishnet tights, she puts on the leather boots just to add to the sexy look.
Stacey Von
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Lovely Stacey Von is almost fully leather clad now as she has the jacket, skirt and boots on so all she needs to do now is put on the leather gloves.
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Gorgeous Stacey Von is looking very happy here as she just loves to wear all this leather as it makes her feel sexy and she is right.
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What is better than a sexy girl like Tasha Holz in a nurses unifom? of course it is a nurses uniform with plenty of leather so she puts on the leather jacket and leather gloves.
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Amy Latina and LJ
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Amy Latina is waiting for LJ to visit her and it is not long before LJ arrives, these lovely girls enjoy wearing leather and they also enjoy each other very much.
Amy Latina and LJ
October 14, 2014 − Amy Latina, LJ
Lovely Amy Latina and LJ were at Amy's flat for the afternoon with nothing to do so they began to enjoy each other's company in plenty of leather of course.
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October 12, 2014 − Sapphire Storm
Sapphire Storm is looking very sexy in this nice and shiny pvc outfit and she puts on a pair of long shiny gloves and plays with the paddle.


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Clad in floral orange shorts and a RailRiders t-shirt while wearing a face of both fun and fierce determination, the RailRiders' venerable top executive issued assurance that families and baseball enthusiasts will be comfortable when the gates open a week from Thursday.
"I guarantee that on Opening Day April 4 it will be at least 60 degrees," said Crain. "To back my guarantee, if it is not 60 degrees on April 4, then anyone who comes to Opening Day will get a free Sunday through Thursday ticket any day the rest of the entire 2013 season." Please note, the free ticket offer excludes the special holiday home game on the Fourth of July.
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From the Calhoun Cardiology Center (Dr White), University of Connecticut School of Medicine, Farmington, CT; Ross Heart Hospital (Dr Cooke), College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH; Division of Cardiology (Dr Kowey), Lankenau Medical Center, and Jefferson Medical College, Philadelphia, PA; University Hospital Aintree (Dr Calverley), Liverpool, England; Respiratory Medicine (Drs Bredenbröker, Goehring, and Mosberg), Nycomed: a Takeda Company, Zurich, Switzerland; Forest Research Institute Inc (Drs Zhu, Lakkis, and Rowe), Jersey City, NJ; and University Kiel and Lung Clinic Grosshansdorf, members of the German Center for Lung Research (Dr Rabe), Grosshansdorf, Germany.
Correspondence to: William B. White, MD, Division of Hypertension and Clinical Pharmacology, Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030-3940; e-mail: firstname.lastname@example.com
For editorial comment see page 723
Funding/Support: Funding was provided by Research and Development, Forest Research Institute Inc, a wholly owned subsidiary of Forest Laboratories, Inc, Jersey City, NJ, and Nycomed: a Takeda Company, Zurich, Switzerland.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.
Evaluation of cardiovascular safety for new therapies for COPD is important because of a high prevalence of cardiac comorbidities in the COPD population. Hence, we evaluated the effects of roflumilast, a novel oral phosphodiesterase 4 inhibitor developed for the treatment and prevention of COPD exacerbations, on major adverse cardiovascular events (MACEs).
Intermediate- and long-term placebo-controlled clinical trials of roflumilast in COPD were pooled and assessed for potential cardiovascular events. Studies comprised 14 12- to 52-week placebo-controlled trials in patients with moderate to very severe COPD. All deaths and serious nonfatal cardiovascular events were evaluated by an independent adjudication committee blinded to study and treatment. The MACE composite of cardiovascular death, nonfatal myocardial infarction, and stroke was analyzed according to treatment group.
Of 6,563 patients receiving roflumilast, 52 experienced MACEs (14.3 per 1,000 patient-years), and of 5,491 patients receiving placebo, 76 experienced MACEs (22.3 per 1,000 patient-years). The MACE composite rate was significantly lower for roflumilast compared with placebo (hazard ratio, 0.65; 95% CI, 0.45-0.93; P = .019).
A lower rate of cardiovascular events was observed with roflumilast than with placebo in patients with COPD, indicating the lack of a cardiovascular safety signal when treating patients with COPD. Potential cardiovascular benefits of roflumilast should be evaluated in future controlled clinical trials.
Cardiovascular diseases are common, serious comorbid conditions in patients with COPD. The risks for developing incident cardiac arrhythmia, venous thromboembolic disorders, myocardial infarction (MI), and stroke in patients with COPD are substantially greater than in healthy people.1,2 Additionally, COPD compounds the risk of cardiovascular death, heart failure, and hospitalizations for cardiovascular diseases when present as a comorbid condition in patients with underlying ischemic heart disease.3,4 The findings are less clear with regard to the impact of COPD on MI rates in patients with underlying heart disease3,5 and perhaps could be better classified through cluster analyses into distinct phenotypes according to the severity of each comorbidity.5
Low-grade systemic inflammation has been proposed as a possible link between COPD and systemic comorbid diseases, such as cardiovascular disease.6 Thus, whether specific therapies for pulmonary disease may have effects on cardiovascular outcomes in patients with COPD is of interest.
Roflumilast is a newly registered, selective, oral, once-daily phosphodiesterase 4 (PDE-4) inhibitor shown to have antiinflammatory activity7 and to produce effective reductions in the rates of acute exacerbations in patients with severe to very severe COPD.8 As part of the clinical development of roflumilast for the treatment of COPD, > 12,000 patients have participated in trials for 12 to 52 weeks.
In the present study, we performed a retrospective assessment of cardiovascular events pooled from the entire clinical database of placebo-controlled roflumilast COPD trials of ≥ 12 weeks (Table 1). The patient-level evaluation was performed by an expert committee blinded to treatment group and unaware of any study results at the time of the assessment. The focus of the analysis was on the incidence of major adverse cardiovascular events (MACEs), as defined previously,16 with roflumilast and its placebo comparator.
One patient each in studies FK1 103 and M2-124 was randomized twice.
Study FK1 103 evaluated withdrawal of roflumilast after 12 wk of treatment vs continued treatment for 24 wk; the switch arm of the study (patients who received roflumilast for 12 wk then placebo for 12 wk) was not included in this pooled analysis.
The prespecified approach by charter was to determine the incidence of MACE as previously defined9 (nonfatal MI, nonfatal stroke, and cardiovascular death) for roflumilast and placebo (or a combination of roflumilast and active agent vs placebo and active agent). All COPD clinical studies from the roflumilast drug safety database that met the following criteria were included in the analysis: (1) randomized trials with a parallel group design, (2) one treatment arm of roflumilast ≥ 250 μg per day, (3) one treatment arm of placebo comparator or placebo and active agent, and (4) a planned double-blind treatment period of ≥ 12 weeks. Fourteen studies met these inclusion criteria. Comparisons presented in this article are roflumilast vs placebo or roflumilast plus salmeterol or tiotropium vs placebo plus salmeterol or tiotropium. Open-label trials, studies that assessed pharmacologic effects or drug-drug interactions rather than clinical outcomes, and single- or multiple-dose studies of roflumilast for disposition assessments were excluded from the analysis. This analysis was conducted with a pool of studies and multiple sites in different countries so that there is not one committee or approval number, but all sites had independent ethics committee or institutional review board approval prior to study start.
The 14 studies comprising this analysis are shown in Table 1. These studies included ambulatory adult patients aged > 40 years who had been given a clinical diagnosis of COPD (confirmed with postbronchodilator [albuterol 400 μg] FEV1/FVC ratio of ≤ 70%).
Patients were randomly assigned to oral roflumilast 250 or 500 μg once daily or to placebo. Patients could use short-acting β2-agonist inhalers as needed and short-acting anticholinergic drugs at stable doses. In some of the trials, they could continue treatment with long-acting β-agonists, long-acting anticholinergic drugs, or inhaled corticosteroids, although use of theophylline was not allowed in the studies. All studies were approved by local ethical committees, and informed consent was obtained prior to enrollment of patients.
The primary analysis in the present study was based on MACEs.16 These events were identified by extracting all deaths and all serious adverse cardiovascular events reported by investigators using the Medical Dictionary for Regulatory Activities, version 11.0. These events comprised the nonadjudicated dataset that was then assessed independently by a three-member cardiovascular adjudication committee (authors W. B. W., G. E. C., P. R. K.) with extensive expertise in cardiac and cerebrovascular end point assessment. All cardiovascular event adjudications were performed while blinded to both drug exposure and type of study to determine whether the cardiovascular events and deaths met the criteria for MACEs. End points sought from the database were (1) nonfatal cardiac events (nonfatal MI, myocardial ischemia, acute coronary syndrome, angina pectoris, resuscitated cardiac arrest, coronary revascularization); (2) all deaths, including from MI, stroke, heart failure, arrhythmia, sudden death or unexplained death, pulmonary embolism, and vascular emergencies (eg, aortic dissection); and (3) cerebrovascular events (ischemic or hemorrhagic stroke or transient ischemic attack). Noncardiovascular deaths were those that did not meet the cardiovascular death criteria.
The following definitions were used in the adjudicated diagnosis of a MACE end point. Acute MI was defined as the presence of two or more of the following criteria: (1) persistent chest pain; (2) cardiac biomarker (myocardial band fraction of creatine phosphokinase, cardiac troponins) levels above the upper limit of normal if spontaneous or more than three or five times the upper limits of normal if after percutaneous coronary intervention or coronary artery bypass graft surgery, respectively; and (3) myocardial injury pattern or development of Q waves in two contiguous ECG leads. Stroke was defined as ischemic or hemorrhagic with an acute, focal neurologic event lasting ≥ 24 h. Imaging studies (CT scan or MRI of the brain) were reviewed and nearly always available but were not mandatory for adjudication of the event. If an imaging study demonstrated an acute cerebrovascular injury that was not associated with a clinical neurologic deficit of > 24 h, the event was characterized as a stroke. Cardiovascular death was defined as that caused by MI, stroke, heart failure, arrhythmia, sudden or unexplained death, pulmonary embolism, or vascular emergencies, such as aortic dissection. The definitions of all events used in the adjudication process were well defined and prespecified in a committee charter.
If events adjudicated by the cardiovascular adjudication committee differed in diagnosis from that assigned by the original reporter, the event was reclassified according to the committee determination. If the data available were deemed insufficient by the committee to permit a definitive diagnosis, then the original reporter's diagnosis was accepted. All events within 30 days of the last drug exposure were considered as exposure associated and included in the analyses. When two clinically linked events occurred within 2 weeks of each other, the more severe event was included in the analysis; for example, if a patient had a hemorrhagic stroke followed by a cardiovascular death 6 days later, cardiovascular death rather than nonfatal stroke would be the event included in the analysis.
The baseline characteristics in the entire cohort were summarized with descriptive statistics for roflumilast and placebo groups. The times to MACE were analyzed in the entire cohort according to the treatment that patients received. In any individual patient, the first event (nonfatal MI, nonfatal stroke, or cardiovascular death) was used for the time-to-event calculations. The safety population was defined a priori in the various trial protocols as all patients who received one or more doses of assigned study medication and was used in all statistical analyses.
Analyses of MACEs were performed for all patients from studies comparing roflumilast (250- and 500-μg doses were combined) with placebo. A Cox proportional hazard model was used to analyze the time to first event. The hazard ratio (HR) of each respective event was expressed as the ratio of roflumilast to placebo with 95% CIs and P values for statistical testing of the null hypothesis that HR = 1.0. When the estimated HR was < 1, roflumilast had a more favorable cardiovascular event profile than the other treatment; the reverse was true if the estimated HR was > 1. All P values and 95% CIs were two sided. To assess the consistency of the treatment effect across various subgroups, similar analyses were performed for patients with and without baseline cardiovascular comorbid conditions, and additional analyses for composite MACE were performed for subgroups on the basis of age group, sex, baseline smoking status, COPD severity, concomitant inhaled corticosteroid use, and concomitant long-acting β-agonist use. Kaplan-Meier plots were generated for each category of events for the overall population.
As shown in Table 2, 12,054 patients were included in the analysis; 6,563 patients were randomized to roflumilast 250 to 500 μg total daily dose, and 5,491 were randomized to placebo. Baseline patient characteristics in the comparisons between roflumilast and placebo were similar for age, sex, COPD severity, and concomitant cardiovascular and pulmonary medications. Similar proportions of the patients in the roflumilast and placebo treatment groups had cardiovascular risk factors of hypertension, diabetes, hyperlipidemia, or ischemic heart disease at baseline (Table 2).
Data are presented as median (range), mean ± SD, or No. (%). GOLD = Global Initiative for Chronic Obstructive Lung Disease; HMG-CoA = 5-hydroxy-3-methylglutaryl-coenzyme A.
The disposition of deaths and nonfatal cardiovascular deaths by the adjudication process is shown in Figure 1 according to treatment assignment. A total of 78 cardiovascular deaths and 51 nonfatal MACEs were adjudicated by the independent committee blinded to treatment assignment. For the primary analysis, results are from adjudicated MACEs. The HRs and 95% CIs based on the Cox proportional hazards model are presented in Table 3. A total of 129 adjudicated MACEs were confirmed in 128 of 12,054 patients in the analysis. Fifty-two MACEs were observed in 52 of 6,563 patients randomized to roflumilast (3,639 patient-years), and 77 MACEs were observed in 76 of 5,491 patients randomized to placebo (3,448 patient-years). For the roflumilast vs placebo adjudicated events comparison, a significant treatment difference was evident (HR, 0.65; 95% CI, 0.45-0.93; P = .019). The HRs for the individual cardiovascular events were < 1 for cardiovascular death, nonfatal MI, and nonfatal stroke for roflumilast vs placebo, but none were statistically significant. Correcting for exposure to treatment, the adjudicated roflumilast event rate was 14.3 per 1,000 patient-years compared with a placebo rate of 22.3 per 1,000 patient-years (Table 3).
Data are presented as No. (%), unless otherwise indicated. CHF = congestive heart failure; CV = cardiovascular; HR = hazard ratio; MACE = major adverse cardiovascular event; MI = myocardial infarction.
Calculated using the Cox proportional hazard model with terms for treatment, age, sex, smoking status, and country pool.
Patients treated with roflumilast and placebo were exposed to study drug for 3,639 and 3,448 patient-y, respectively. Exposure-adjusted incidence rates per 1,000 patient-y were 14.3 (roflumilast) and 22.3 (placebo) for composite MACEs, 9.6 (roflumilast) and 12.5 (placebo) for CV death, 3.0 (roflumilast) and 6.4 (placebo) for nonfatal MI, and 1.6 (roflumilast) and 3.5 (placebo) for nonfatal stroke.
Significant at P < .05.
Kaplan-Meier plots for the probability of experiencing MACEs and the various components are presented in Figure 2. These plots were truncated after 372 days. With the exception of nonfatal stroke, fatal and nonfatal cardiovascular events accrual began to separate between 90 and 150 days of exposure, with lower event rates for roflumilast than for placebo.
Risk factors recorded at baseline included the presence of hypertension, diabetes mellitus, hyperlipidemia, and a history of heart disease (Table 2). Adjudicated event rates were higher in patients with baseline cardiovascular risk factors than in those without baseline cardiovascular risk (Table 4). HRs for MACEs found in patients treated with roflumilast relative to placebo in patients without cardiovascular diseases or risk factors at baseline were lower than in those with cardiovascular comorbid conditions. Adjusting for cardiovascular risk factors at baseline did not materially affect the HR for MACEs. There were significantly fewer MACEs for roflumilast than for placebo in the subgroup of patients with COPD who did not have cardiovascular comorbid conditions at baseline (Table 4).
Data are presented as No. (%), unless otherwise indicated. See Table 3 legend for expansion of abbreviations.
Calculated using Cox proportional hazard model with terms for treatment, age, sex, smoking status, and country pool.
Includes ischemic heart disease, type 2 diabetes, dyslipidemia, and hypertension (see Table 2).
Adjudicated event rates according to age, sex, smoking status, COPD severity, and concomitant long-term pulmonary medication use are shown in Figure 3. HRs were similar across age, sex, and smoking status. There were no significant interactions for COPD severity, concomitant inhaled corticosteroid use, or long-acting β-agonist use. However, reductions in MACEs were significant in patients with severe COPD (GOLD [Global Initiative for Chronic Obstructive Lung Disease] stage III), in those using concomitant inhaled corticosteroids, and in those not using long-acting β-agonists and not in the corresponding subgroups.
Subanalyses of the four trials carried out for 1 year demonstrated that exacerbations of COPD were reduced significantly by roflumilast relative to placebo. Between patients with and without exacerbations, the proportions with MACEs were similar (1.7% and 1.6%, respectively). Between patients with and without MACEs, the proportions experiencing exacerbations were similar (43.2% and 42.1%, respectively).
In an analysis of clinical trials involving > 12,000 patients, reductions in MACEs (nonfatal MI, nonfatal stroke, and cardiovascular death) were found in patients treated with the PDE-4 inhibitor roflumilast compared with patients who received placebo. Of note, subgroup analyses indicated that the risk reduction might be more prominent in patients with severe vs moderate COPD. Changes in MACEs for roflumilast relative to placebo were not altered substantially as a result of baseline cardiovascular risk factors. The cardiovascular effects of roflumilast appeared to be independent of age, sex, smoking status, use of concomitant COPD treatments such as long-acting β-agonists and inhaled steroids, and COPD exacerbations.
Patients with COPD are known to have higher rates of cardiovascular mortality and hospitalizations compared with age- and sex-matched control patients without COPD,2,17,18 and the rates of cardiovascular death and MI in the present analysis are similar to those previously published.19‐21 Of note, stroke rates typically are not reported in most studies evaluating cardiovascular event rates in trials or cohorts of COPD. The rates of cardiac death and MI vary substantially in analyses of COPD populations according to pulmonary and cardiovascular disease severity, the era in which the study was performed, and the duration of the observational period.3‐5,20‐22 In the present study of > 12,000 patients with COPD in which about 17% had ischemic heart disease, the placebo MACE rate was 1.4%, and the roflumilast MACE rate was 0.8%. In contrast, in a VALIANT (Valsartan in Acute Myocardial Infarction Trial) substudy3 of 1,258 patients with COPD, all of whom had a very recent MI, the average rate of cardiovascular death, MI, and heart failure was about 15%. In a pooled analysis of 19 studies comparing tiotropium to placebo in 7,819 much-healthier patients with moderate to severe with COPD, the incidence of cardiovascular death was only 0.35%20 and likely reflects both the lower cardiovascular morbidity chosen for clinical trial participation and the much shorter observation time.
In the present study, patients with cardiovascular risk factors or disease at baseline had two to three times the MACE rate as patients without these at baseline. In both subgroups of patients, roflumilast conveyed a reduction in cardiovascular events, although the change appeared to be more substantial in patients without baseline cardiovascular diseases.
Studies have shown that patients with severe and moderate COPD also have evidence of systemic inflammation, including elevated circulating levels of tumor necrosis factor, IL-6, and C-reactive protein, compared with healthy people.18,23‐25 Additionally, Sin and Man18 showed that an important link exists between systemic inflammation in COPD and cardiac injury in association with varying levels of airflow obstruction. Unfortunately, proinflammatory markers were not obtained in all the studies used in the present pooled analysis of cardiovascular events. However, it is known that PDE-4 inhibition provides a wide range of antiinflammatory actions in vitro26 and in vivo.27 The oral PDE-4 inhibitor roflumilast has been shown to reduce airway inflammation in COPD as assessed by sputum neutrophil and eosinophil counts,7 an antiinflammatory benefit that may be associated with the ability of the drug to reduce exacerbations of COPD.8 Hence, the reduction in MACEs seen with roflumilast compared with placebo in the present analysis may be partly related to reductions in vascular inflammation induced by PDE-4 inhibition.
Few data exist with regard to potential cardiovascular benefits of therapies for COPD. Extensive analyses of the effects of long-acting β-agonists and inhaled corticosteroids on cardiovascular events have shown no harm,28,29 and a trend toward a mortality benefit for the combination of salmeterol and fluticasone proprionate has been observed in the TORCH (Toward a Revolution in COPD Health) trial.30 The long-term effects of the inhaled long-acting anticholinergic agent tiotropium on cardiovascular events was first reported in the UPLIFT (Understanding Potential Long-Term Impacts on Function With Tiotropium) trial19 and later reviewed in a pooled analysis of shorter-term placebo-controlled trials of the agent.31 In UPLIFT, the incidence rate of serious cardiac events was 16% lower for tiotropium than for placebo (P < .05), with an 11% reduction seen in all-cause mortality (P = .09).19 In a later pooled analysis of nearly 20,000 patients, the relative risk of mortality while receiving tiotropium was significantly reduced by 23%.31 In the present study of roflumilast in patients with COPD, the relative reduction in MACE compared with placebo was 35%, with all three components (cardiovascular death, nonfatal MI, and nonfatal stroke) showing a similar directional change that favored roflumilast.
Although the studies included in this pooled analysis were not designed to assess the relative effects of roflumilast vs placebo on cardiovascular outcomes, the baseline characteristics of the population, including age, underlying cardiovascular risk factors, severity of COPD, and concomitant cardiac and pulmonary therapies were similar for the roflumilast and placebo treatment groups (Table 2). Furthermore, although the present sample size is quite large, the trials were for ≤ 1 year of observation, so the patient-years of exposure are relatively small compared with primary cardiovascular outcome studies. However, the event rates in the placebo-controlled trials analyzed here were similar to those in trials and analyses of cardiovascular events in patients with COPD.17‐19,29,31 Nevertheless, the description of absolute risk of MACEs for roflumilast relative to placebo must be interpreted with caution.
This cardiovascular safety analysis of data from randomized controlled trials of roflumilast in patients with COPD for up to 1 year demonstrates a lower incidence of cardiovascular events in those treated with roflumilast vs placebo. Further resolution of the absolute and relative cardiovascular effects of systemic PDE-4 inhibition will require purposefully designed prospective randomized trials of appropriate durations.
Author contributions: Dr White had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr White: contributed as principal investigator and chair of the cardiovascular adjudication committee to the conception and design of the analysis and drafting of the manuscript.
Dr Cooke: contributed as a member of the cardiovascular adjudication committee to the data interpretation and critical review of the manuscript.
Dr Kowey: contributed as a member of the cardiovascular adjudication committee to the data interpretation and critical review of the manuscript.
Dr Calverley: contributed as a member of the steering committee for roflumilast studies to the data interpretation and critical review of the manuscript.
Dr Bredenbröker: contributed to the clinical operations for the conduct of the study, data acquisition, and critical review of the manuscript.
Dr Goehring: contributed to the clinical operations for the conduct of the study, data acquisition, and critical review of the manuscript.
Dr Zhu: contributed to the biometric analysis, data analysis, and critical review and editing of the manuscript.
Dr Lakkis: contributed to the biometric analysis, data analysis, and critical review and editing of the manuscript.
Dr Mosberg: contributed as a safety physician involved with the clinical study operations to the data acquisition and interpretation and critical review of the manuscript.
Dr Rowe: contributed as a safety physician involved with the clinical study operations to the data acquisition and interpretation and critical review of the manuscript.
Dr Rabe: contributed as a member of the steering committee for roflumilast studies to the data interpretation and critical review of the manuscript.
Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr White has research funding from the National Institutes of Health unrelated to the content of this article. He is the president of the American Society of Hypertension, Inc for 2012 to 2014. Dr White is a consultant regarding the cardiovascular safety of numerous noncardiac drugs and devices (steering committees, data safety monitoring committees, and cardiovascular end point committees) for companies that include Ardea Biosciences, Inc; AstraZeneca; Dendreon Pharmaceuticals; EMD Serono, Inc; Forest Research Institute, Inc; Eli Lilly and Company; Roche; Teva Pharmaceutical Industries, Ltd; and Takeda Global Research and Development Center, Inc. Drs Cooke and Kowey are prior members of the cardiovascular adjudication committee for roflumilast and are paid consultants to Nycomed. Drs Calverley and Rabe are members of the steering committee for roflumilast trials and are paid consultants to Nycomed. Drs Bredenbröker and Goehring are full-time employees of Nycomed. Drs Zhu, Lakkis, and Rowe are full-time employees of Forest Research Institute Inc. Dr Mosberg was a full-time employee of Nycomed until June 2012.
Role of sponsors: Nycomed: a Takeda company supplied the original data and source documents to the cardiovascular adjudication committee. All data in this analysis were available to all authors for review and assessment. None of the authors received any financial compensation for any aspect of manuscript preparation. No medical writer was involved in drafting the manuscript.
Other contributions: Morgan Hill, PhD, Prescott Medical Communications Group (Chicago, Illinois), provided assistance with the preparation of figures and tables, which was made possible by funding from Forest Research Institute Inc.
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Akron Zips Take Nation's Longest Current Winning Streak on the Road to Eastern Michigan
A year after a heart-breaking loss in the Mid-American Conference title game to the Ohio Bobcats, the Akron Zips are once again up to their winning ways. They enter tonight's game with a 10-0 MAC record while the home team, Eastern Michigan, enters with a 4-5 record in conference.
The Zips (19-4) own the longest current winning streak in the country. The 15-game winning streak is tied for the third-longest in college hoops this season, behind only Kansas' 18-gamer and Michigan's 16-game win streak.
You might have heard a little about Eastern Michigan (11-12) a few weeks back as they held Northern Illinois to an NCAA-record low four points in the first half, en route to a 42-25 win. My cohort Riley Schmitt summed it up perfectly here.
Akron is 19-4 overall on the season and is ranked top-50 nationally in three of four main offensive categories (PPG, APG, FG%), while being just outside in rebounds per game (54th).
And don't think they don't play any defense—they're top-75 nationally defensively in all the aforementioned stat categories, to go along with being ranked 10th in Division I with 5.8 blocks per game, thanks in large part to seven-foot center Zeke Marshall's 3.5 per game.
The blue-and-gold feature an array of scoring options, with eight players averaging at least five points per game, led by Marshall (12.5 ppg) and junior Demetrius Treadwell (11 ppg). Junior guard Alex Abreu runs the point for an offense that averages 15.2 apg.
The Eagles will have their hands full tonight as they come in alternating wins and losses the previous six contests, losing their last game at Toledo, 60-52.
Their offense is putrid, averaging just over 57 ppg thanks to 39.7 percent shooting. They are a bit stingy on defense, allowing only 59.6 ppg (36th in Division I)–thanks to the 25 allowed against NIU. This is the only meeting between these two this year, but if last year's result (a 77-47 Akron win) is any indication of what's to come tonight, it won't be pretty.
Akron is a wrecking ball in the MAC and they don't appear to be slowing down—their 10 MAC wins come by an average of 11 points. They're currently seventh in the Mid-Major Top-25 Poll.
Even though this one is on the road, the atmosphere in the Ypsilanti Center shouldn't shake the head coach Keith Dambrot's Zips–after all, EMU only averages 914 fans per home game.
The Zips should have no problem getting to 11-0 and extending their winning streak to 16 games. It's showtime.
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3 of 14 people found the following review helpful
I'm a little overwhelmed!,
This review is from: The Tales of Beedle the Bard, Collector's Edition (Offered Exclusively by Amazon) (Hardcover)
While do agree with the majority of reviewers' comments about the quality of this Collector's Edition, at the same time, on opening the box, I was surprised, and a little disappointed, to find a "Dobby" size book in a "Hagrid" size case.
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Showing 1-2 of 2 posts in this discussion
Initial post: 10 Dec 2008 14:26:22 GMT
Bella Blue says:
Why are you judging it based on the size! Have you read any of the stories yet? Why dont you talk about the stories?
Posted on 29 Jan 2009 08:39:05 GMT
Grad Daniel says:
it seems that you did not read the product description, or even looked at the image before you bought. if the description was misleading, your disappointment would have been understandable.
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text:
Meet the 'Angel Priest' that Appeared at the Scene of that Car Accident
Remember the story from last week about a mysterious "angel" priest who appeared at the scene of a car accident to pray with an injured driver before mysteriously vanishing? Well, his name is Rev. Patrick Dowling. After emergency workers and the crash victims claimed that an unnamed priest disappeared after saying a prayer with an injured traveler, the story went viral, with some speculating that the man may have been an angel in disguise. Rev. Dowling may be an angel—he's just not the supernatural kind. He explained the incident in the comment section of a news article, saying he parked about 150 yards away from the scene of the accident and asked the sheriff for permission to approach. After praying with the victims and rescue workers, he left and continued on his way. Only later did he learn that his appearance had led to a story about a visit from angels. Though, in his comment, he did say that there were "angels" at the scene of the accident that day. "I think there may have been angels there too and, in this context, I congratulate the fire team from New London and Hannibal, the Sheriff/deputies of Ralls County, the Highway Patrol personnel, the helicopter team, the nurses and all who worked so professionally. God has blessed your work. I hope the credit goes where it is due" …
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1 Comment
Both stories were great stories...


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Honda CRV with steam/smoke issue??
Have a CRV and my daughter said she saw steam/smoke coming from the rear left (non-exhaust side) of the vehicle when driving. When she pulled over and went to look it was gone..
Any ideas of where to start searching??
1 Answer
Could be a brake issue. Perhaps the caliper or wheel cylinder got stuck on that wheel making the brake drag. Any strange odors? She also may have driven through a large puddle. Sometimes when water from a puddle splashes on the hot exhaust system you'll see steam for a few seconds. HTH. -Jim
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NEW ROCHELLE, N.Y. – Rosemary Ward, a longtime New Rochelle resident, died Dec. 9. She was 83.
Ward was born Aug. 18, 1929, in New Rochelle to Martin James and Rose O'Connell Tormey. She was married to Patrick Ward, who predeceased her.
She is survived by a son, Timothy (Ann) Ward; a daughter, Lorraine (Michael) Bush; a brother, Martin Tormey; three grandchildren; five great-grandchildren; and two nieces. She was predeceased by a sister, Patricia.
There will be a funeral service at noon Saturday at Lloyd Maxcy and Sons Beauchamp Chapel in New Rochelle.
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HOULKA – Decklain Haze Rain Paden, infant child of Letosha Joy Monts and Michael Anthony Paden Jr., passed away Monday, Nov. 11, 2013, at North Mississippi Medical Center. Services will be at 2 p.m. Saturday, Nov. 16, at Tutor Memorial Funeral Home in Pontotoc. Burial will be in Rose Hill Cemetery. Visitation will be from […]
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All the news from the annual Google I/O event, including the latest on Android.
The $180 Samsung Galaxy Tab 4 is a fine choice for a budget tablet, but it's ultimately bested by great older devices, and new slates that are cheaper still.
Lollipop is a tasty update with a candy-colored, cohesive design and updated core features.
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The LG G Pad 7.0 is a basic budget tablet that slightly outmatches its competition with a supremely comfortable build, modest software extras and bargain-basement pricing.
Google's Nexus devices are due to catch the latest flavor of Android KitKat on Monday, says T-Mobile. Will it finally happen?
Apple has introduced the iPad Air 2, purportedly the thinnest tablet ever, and a new iPad Mini 3.
Everything you need to know about buying Apple's new iPads.
Screenshots appear in the iTunes Store showing the two new devices with the addition of a Touch ID fingerprint scanner.
Thanks to its stellar performance and affordable price, the Nexus 7 is the Android tablet to get.
Expected to grace select Android smartphones in the next few months, HTC's take on Lollipop looks very Google-y.
A purported note to app developers obtained by Android Police claims Google's mobile OS will lick its way to devices next month.


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Latest Great Lakes Stories
CHEYENNE, Wyo., May 6, 2011 /PRNewswire/ -- Great Lakes Aviation, Ltd.
The US Department of the Interior on Wednesday said it is formally removing the gray wolf of the Rocky Mountain region from the endangered species list, after a Congressional order was made last month.
A new paper appearing in the Proceedings of the National Academy of Sciences (PNAS) suggests that people, governments, and institutions that shape the way people interact may be just as important for determining environmental conditions as the environmental processes themselves.
The ongoing spread of non-native mussels in the Great Lakes has caused "massive, ecosystem-wide changes" throughout lakes Michigan and Huron, two of the planet's largest freshwater lakes.
Choosing optimal growing locations limits algal biofuel's water use.
CHEYENNE, Wyo., April 7, 2011 /PRNewswire/ -- Great Lakes Aviation, Ltd.
SOUTHFIELD, Mich., March 14, 2011 /PRNewswire/ -- Automotive leasing in the United States in 2010 represented nearly 19 percent of overall vehicle transactions, according to Polk.
CHEYENNE, Wyo., March 8, 2011 /PRNewswire/ -- Great Lakes Aviation, Ltd.
Conservation and fishing groups are calling on the federal government to improve outdated laws and prevent the next invasion WASHINGTON, Feb.
A panel of scientists speaking today at the annual meeting of the American Association for the Advancement of Science (AAAS) unveiled new research and models demonstrating how climate change could increase exposure and risk of human illness originating from ocean, coastal and Great Lakes ecosystems, with some studies projecting impacts to be felt within 30 years.
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The Great lakes have a huge impact in the weather for the cities that are near the lakes. In the fall and early winter months the lakes can create intense snowfall events known as "Lake Effect Snow". The reason that this occurs has to do with the water temps of the lakes and also the temps of the air that is moving across them. When an Alberta Clipper system forms in Canada and moves Southeastward towards the US, it brings that cold air and strong Northwest winds over the warmer waters....
If you look at our weather map above you see a warm front extending from Iowa into the Great Lakes region. What a warm front does is separate warm air from cool air. On the north side of the front the temps will be about 15-20 degrees cooler than on the south side of the front. The warm front is depicted on a weather map as having red half circles. The reason for using half circles it to show that advancing of the warm air from the south. Winds ahead of the warm front are from the...
Symbol: PRPUP Group: Dicot Family: Rosaceae Duration: Perennial Growth Habit: Shrub Native Status: L48 N CAN N Synonyms: CEPU8 Cerasus pumila (L.) Michx. Distribution: County distributions for the following U.S. states are available at PLANTS:NY, OH, PA Classification: Kingdom Plantae – Plants Subkingdom Tracheobionta – Vascular plants Superdivision Spermatophyta – Seed plants...
The snowbelt is a North American region that lies downwind of the Great lakes, where heavy snowfall is common on mostly the eastern and southern shores of the Great Lakes. Lake-effect snow is caused by cold air picking up moisture while crossing the lake and then releasing it as snow when the air cools over land. Throughout much of the winter, lakes produce lake-effect snow and continuously cloudy skies. This phenomenon continues as long as the air temperature is colder than the water...
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- One of a pair of round metal cymbals attached to the fingers and struck together for rhythm and percussion in belly dancing.


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EASTCHESTER, N.Y. - Employers around Eastchester, Tuckahoe and Bronxville have plenty of job openings this week.
- CVS is seeking a retail store manager.
- The John McEnroe Tennis Academy is looking for tennis professionals.
- Adidas is hiring a retail store associate.
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- Michael Page is looking for a commercial loan review consultant.
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- Sarah Lawrence College is hiring an assistant director for its internship program.
- AVI Food Systems is in need of a chef.
If you have a job listing you would like posted on The Eastchester or Bronxville Daily Voice, e-mail email@example.com.
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Recipe of the Day
Big M's Spicy Lime Grilled Prawns
Prawns are marinated in lime, onion, and garlic and then quickly grilled. A wonderful addition to an outdoor meal.
Marcus Hender
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