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Publications (54)95.59 Total impact
Article: Metformin Inhibits Tumor Cell Migration via Down-regulation of MMP9 in Tamoxifen-resistant Breast Cancer Cells.[Show abstract] [Hide abstract]
ABSTRACT: Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.Anticancer research 08/2014; 34(8):4127-34. · 1.71 Impact Factor
Article: The use of everolimus to target carcinogenic pathways in a patient with renal cell carcinoma and tuberous sclerosis complex: a case report.[Show abstract] [Hide abstract]
ABSTRACT: An increased understanding of the genetic pathways involved in renal cell carcinoma has resulted in the development of various drugs that target relevant signaling cascades for the specific treatment of this disease. However, no validated predictive markers have been identified to guide the decision whether patients should receive vascular endothelial growth factor-targeted therapy or mammalian target of rapamycin-targeted therapy. We present what is, to the best of our knowledge, the first case of renal cell carcinoma in a patient with tuberous sclerosis complex who was successfully treated with everolimus. The patient was a 49-year-old Korean woman with tuberous sclerosis complex and recurrent renal cell carcinoma. The patient was treated with the tyrosine kinase inhibitor sunitinib followed by the mammalian target of rapamycin inhibitor everolimus. This treatment resulted in a prolonged response and significant clinical benefit. Notably, everolimus ameliorated the symptoms related not only to renal cell carcinoma but also to tuberous sclerosis complex. This case provides a rationale for the use of everolimus as first-line treatment for this specific patient population in order to target the correct pathway involved in carcinogenesis.Journal of Medical Case Reports 03/2014; 8(1):95.
Article: Increased expression of vascular endothelial growth factor and hypoxia inducible factor-1α in lung tissue of patients with chronic bronchitis.[Show abstract] [Hide abstract]
ABSTRACT: Vascular endothelial growth factor (VEGF) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), but its site-specific expression in lung tissue and the relationship with hypoxia inducible factor-1 alpha (HIF-1α) expression in chronic bronchitis (CB) type COPD have not been studied. We evaluated the expression of VEGF and its receptors in various compartments of lung tissue in three groups: non-smokers with normal lung function (non-smokers, n=10), smokers without COPD (healthy smokers, n=10) and smokers with CB (CB, n=10), using immunohistochemical staining and Western blotting. The expression of HIF-1α was assessed by enzyme-linked immunosorbent assay. Compared with healthy smokers, VEGF expression in CB was significantly increased in bronchiolar epithelium, vascular endothelium and vascular smooth muscle (p<0.05). VEGF receptor (VEGFR)-2 expression in CB was also increased in bronchiolar smooth muscle, vascular endothelium and vascular smooth muscle compared with healthy smokers (p<0.05). The level of HIF-1α was increased in CB compared with healthy smokers and positively correlated with those of VEGF (r=0.64, p<0.05). VEGF and VEGFR-2 expression was up-regulated in CB and increased expression of VEGF was related with HIF-1α. HIF-1α-regulated VEGF overexpression may be a characteristic of chronic bronchitis.Clinical biochemistry 01/2014; · 2.02 Impact Factor
Article: Naked cuticle Drosophila 1 expression in histologic subtypes of small adenocarcinoma of the lung.[Show abstract] [Hide abstract]
ABSTRACT: Naked cuticle Drosophila 1 (NKD1) has been related to non-small cell lung cancer in that decreased NKD1 levels have been associated with both poor prognosis and increased invasive quality. Forty cases of lung adenocarcinoma staged as Tis or T1a were selected. Cases were subclassified into adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and small adenocarcinoma (SAD). Immunohistochemical studies for NKD1 were performed. Forty samples comprised five cases of AIS (12.5%), eight of MIA (20.0%), and 27 of SAD (67.5%). AIS and MIA showed no lymph node metastasis and 100% disease-free survival, whereas among 27 patients with SAD, 2 (7.4%) had lymph node metastasis, and 3 (11.1%) died from the disease. Among the 40 cases, NKD1-reduced expression was detected in 8 (20%) samples, whereas normal expression was found in 15 (37.5%) and overexpression in 17 (42.5%). Loss of NKD1 expression was significantly associated with lymph node metastasis (p=0.001). All cases with predominant papillary pattern showed overexpression of NKD1 (p=0.026). Among MIA and SAD, MIA had better outcomes than SAD. Down-regulated NKD1 expression was closely associated with nodal metastasis, and overexpression was associated with papillary predominant adenocarcinoma.The Korean Journal of Pathology 06/2013; 47(3):211-8. · 0.17 Impact Factor
Article: Myxoid liposarcoma with cartilaginous differentiation: a case study with cytogenetical analysis.[Show abstract] [Hide abstract]
ABSTRACT: Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.The Korean Journal of Pathology 06/2013; 47(3):284-8. · 0.17 Impact Factor
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ABSTRACT: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer treatment. A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for EGFR gene amplification. EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors. EGFR gene amplification and high polysomy (fluorescent in situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2(+), EGFR(+), cytokeratin 5/6(-) (CK5/6(-)) group, 11.2% of the HER-2(-), EGFR(+), CK5/6(-) group, and 19.1% of the HER-2(-), EGFR(+), CK5/6(+) group. FISH-positive cases were detected in 8.3% of the EGFR protein 1(+) expression cases, 15.9% of 2(+) expression cases, and 38.5% of 3(+) expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6. EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients.The Korean Journal of Pathology 04/2013; 47(2):107-15. · 0.17 Impact Factor
Article: Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin.[Show abstract] [Hide abstract]
ABSTRACT: Increased expression of thymidylate synthase (TS) is thought to be associated with resistance to antifolate drugs such as pemetrexed. Excision repair cross-complementation group 1 (ERCC1) is a predictive marker for platinum-based chemotherapy. This study evaluated whether the expression of TS and ERCC1 proteins is associated with clinical outcomes of the patients with pulmonary adenocarcinoma who were treated with pemetrexed/cisplatin as first-line chemotherapy. The expressions of TS and ERCC1 were evaluated by immunohistochemistry in biopsy specimens obtained from patients with pulmonary adenocarcinoma who had received pemetrexed/cisplatin as first-line treatment. Patients were categorized according to median H-score. Response rate (RR), progression-free survival (PFS) and overall survival (OS) were analyzed retrospectively. Both low TS and ERCC1 expressions were significantly associated with better RR (p=0.037 and p=0.015, respectively) and longer PFS (p<0.001 and p=0.004, respectively). Low ERCC1 expression was also associated with longer OS (p=0.003) while TS only showed a trend (p=0.105). TS expression was independent predictor for the better PFS in multivariate analysis (hazard ratio [HR]=0.32, 95% confidence interval [CI]: 0.14-0.76). Combining the two markers, the low TS/low ERCC1 group showed significantly longer PFS (HR=0.48, 95% CI: 0.26-0.75) and OS (HR=0.57, 95% CI: 0.36-0.89) compared with high TS/high ERCC1 group. Protein expressions of TS and ERCC1 were associated with clinical outcomes in patients with pulmonary adenocarcinoma who were treated with pemetrexed/cisplatin as first-line chemotherapy. TS and ERCC1 protein expressions can be potential predictive markers in this setting.Lung cancer (Amsterdam, Netherlands) 03/2013; · 3.14 Impact Factor
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ABSTRACT: To investigated the incidence of diversion colitis (DC) and impact of DC symptoms on quality of life (QoL) after ileostomy reversal in rectal cancer. We performed a prospective study with 30 patients who underwent low anterior resection and the creation of a temporary ileostomy for the rectal cancer between January 2008 and July 2009 at the Department of Surgery, Korea University Anam Hospital. The participants totally underwent two rounds of the examinations. At first examination, endoscopies, tissue biopsies, and questionnaire survey about the symptom were performed 3-4 mo after the ileostomy creations. At second examination, endoscopies, tissue biopsies, and questionnaire survey about the symptom and QoL were performed 5-6 mo after the ileostomy reversals. Clinicopathological data were based on the histopathological reports and clinical records of the patients. At the first examination, all of the patients presented with inflammation, which was mild in 15 (50%) patients, moderate in 11 (36.7%) and severe in 4 (13.3%) by endoscopy and mild in 14 (46.7%) and moderate in 16 (53.3%) by histology. At the second examination, only 11 (36.7%) and 17 (56.7%) patients had mild inflammation by endoscopy and histology, respectively. There was no significant difference in DC grade between the endoscopic and the histological findings at first or second examination. The symptoms detected on the first and second questionnaires were mucous discharge in 12 (40%) and 5 (17%) patients, bloody discharge in 5 (17%) and 3 (10%) patients, abdominal pain in 4 (13%) and 2 (7%) patients and tenesmus in 9 (30%) and 5 (17%) patients, respectively. We found no correlation between the endoscopic or histological findings and the symptoms such as mucous discharge, bleeding, abdominal pain and tenesmus in both time points. Diarrhea was detected in 9 patients at the second examination; this number correlated with the severity of DC (0%, 0%, 66.7%, 33.3% vs 0%, 71.4%, 23.8%, 4.8%, P = 0.001) and the symptom-related QoL (r = -0.791, P < 0.001). The severity of DC is related to diarrhea after an ileostomy reversal and may adversely affect QoL.World Journal of Gastroenterology 01/2013; 19(4):542-9. · 2.55 Impact Factor
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ABSTRACT: MicroRNAs (miRs) are small noncoding RNAs that have been reported to be promising diagnostic tools. We used quantitative real-time reverse transcription PCR (RT-qPCR) to analyze differentially expressed miRNAs in prostate tumor samples to determine its prognostic value. From 2007 to 2009, tumor tissues were obtained from 73 radical prostatectomy specimens. Differentially expressed miR-96, -145 and -221 were validated by TaqMan RT-qPCR using all 73 tissues. The prognostic value was assessed in terms of biochemical recurrence using Kaplan-Meier and Cox regression analyses. For our patient cohort, the mean age was 64.7 years (50-76 years) and the mean prostate-specific antigen (PSA) was 7.5 ng ml(-1). During the follow-up period (mean, 19.4 months), 14 of 73 (19.2%) patients developed biochemical recurrence. Expression of miR-96, -145 and -221 correlated strongly with each other, but there were no correlations between miRNA expression and clinicopathologic parameters. Kaplan-Meier survival curves using the log-rank test showed a decreased biochemical recurrence-free interval with pathologic stage (P<0.001). In addition, patients with Gleason scores over 8, compared with those with a Gleason score of 6, showed a decreased biochemical recurrence-free interval in Kaplan-Meier analysis (P=0.001). However, expression of miR-96, -145 and -221 did not correlate with the biochemical recurrence interval in Kaplan-Meier survival curves or by multivariate analysis using the Cox proportional hazard regression model, either. In conclusion, we did not observe a significant correlation between the expression of miR-96, -145 and -221 and clinicopathologic parameters. To utilize miRNA as a diagnostic tool in clinical practice, more research is needed to understand miRNA mechanisms, identify miRNA targets, and further characterize miRNA function.Asian Journal of Andrology 08/2012; 14(5):752-7. · 2.14 Impact Factor
Article: Successful salvage treatment of steroid-refractory bronchiolar COP with low-dose macrolides.[Show abstract] [Hide abstract]
ABSTRACT: Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by fibroblastic tissues that occupy the lumina of alveoli and alveolar ducts or respiratory bronchioles. Although adequate doses and durations of glucocorticoids can improve its condition, COP is sometimes resistant to glucocorticoid therapy and is often lethal.Herein, a very rare case of 'bronchiolar COP' that was confined to the respiratory bronchioles is reported. This case indicates that macrolides may act as anti-inflammatory agents in patients with COP. Timely and precise pathological diagnosis may corroborate clinician diagnoses and eventually improve chances to overcome the disease.Pathology International 02/2012; 62(2):144-8. · 1.72 Impact Factor
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ABSTRACT: To report a case of oxaliplatin-combined chemotherapy-induced interstitial lung disease. A 57-year-old man was referred complaining of dyspnea and fever after treatment with an oxaliplatin-combined chemotherapeutic agent for metastatic colorectal cancer. Fever development and spontaneous subsidence were observed during the chemotherapeutic course repeatedly until the 9th cycle. A computer-tomographic (CT) scan revealed bilateral, peripherally distributed, patchy consolidation suggestive of an interstitial lung disease. As a confirmative step, video-assisted thoracoscopic surgical biopsy was attempted; the characteristic intraluminal organizing fibrous plug in the bronchioles and alveoli was seen. Corticosteroid therapy was administered, which rapidly improved the patient's symptoms and chest CT findings. This case showed that oxaliplatin may be implicated in the etiology of interstitial lung disease, since withdrawal of the drug resulted in improvement of interstitial lung disease.Medical Principles and Practice 01/2012; 21(1):89-92. · 0.96 Impact Factor
Article: D2-40, Podoplanin, and CD31 as a Prognostic Predictor in Invasive Ductal Carcinomas of the Breast.[Show abstract] [Hide abstract]
ABSTRACT: Distant metastasis and recurrence are major prognostic factors associated with breast cancer. Both lymphovascular invasion (LVI) and blood vessel invasion (BVI) are important routes for metastasis to regional lymph nodes and for systemic metastasis. Despite the importance of vascular invasion as a prognostic factor, application of vascular invasion as a histopathological criterion is controversial. The aim of this study was to distinguish LVI from BVI in prognosis and recurrence of breast cancer using an endothelial subtype specific immunohistochemical stain (podoplanin, D2-40, and CD31). Sections from 80 paraffin-embedded archival specimens of invasive breast cancer were stained for podoplanin, D2-40, or CD31 expression. Immunohistochemical staining results were correlated with clinicopathological features, such as tumor size, status of lymph node metastases, estrogen receptor status, progesterone receptor status, human epidermal growth factor receptor-2 expression, and recurrence. Patients with ductal carcinoma in situ and stage IV breast cancer were excluded. A significant correlation was found between D2-40 LVI positivity and lymph node metastasis (p=0.022). We found a significant correlation between D2-40 LVI positivity and recurrence of breast cancer (p=0.014). However, no significant correlation was found between BVI and recurrence. A poorer disease free survival was shown for D2-40 positive LVI (p=0.003). In a multivariate analysis, the presence of D2-40 LVI positivity revealed a significant association with decreased disease-free survival. D2-40 LVI positivity was a more prognostic predictor of breast cancer than BVI.Journal of breast cancer. 06/2011; 14(2):104-11.
Article: Two different renal cell carcinomas and multiple angiomyolipomas in a patient with tuberous sclerosis.[Show abstract] [Hide abstract]
ABSTRACT: We report a case of tuberous sclerosis associated with two histologically different renal cell carcinomas (RCCs) and multiple angiomyolipomas (AMLs) in the same kidney. A 43-year-old female was admitted to our hospital with left flank pain and a huge palpable mass in the left flank area. Abdominal computed tomography revealed two concurrent RCCs and multiple AMLs in the left kidney. Because of the clinical suspicion of RCC, the patient underwent left radical nephrectomy. On gross examination, the total size of the resected left kidney was 30.5×17×8 cm. Microscopically, the upper pole tumor features were consistent with chromophobe RCC and the midpole tumor was a clear-cell RCC. The multifocal masses in the remaining remnant parenchyma were AMLs. Six months after surgery, the patient is healthy without signs of tumor recurrence.Korean journal of urology 10/2010; 51(10):729-32.
Article: Dedifferentiated liposarcoma of retroperitoneum: spectrum of imaging findings in 15 patients.[Show abstract] [Hide abstract]
ABSTRACT: Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arises in the background of a preexisting well-differentiated liposarcoma. The purpose of this work is to evaluate the spectrum of radiologic appearance of retroperitoneal dedifferentiated liposarcoma with clinicopathologic features. Radiologic images and clinical histories of 15 patients with histologically verified retroperitoneal dedifferentiated liposarcoma were retrospectively studied. Patients included 11 men and 4 women, with mean age of 55.8 years (range, 36-74 years), and they underwent computed tomography (CT) (n=15) and magnetic resonance imaging (MRI) (n=5). The mean size of the tumor was 22.6 cm with a range of 9.5-38 cm. Both CT and MRI showed well-circumscribed, large round, or lobulated retroperitoneal mass. The appearance of the tumor was classified as follows: Category I, nonfatty component within predominant fatty mass (n=5); Category II, focal fatty component within large nonfatty mass (n=6); Category III, well-defined fatty mass and well-defined nonfatty mass (n=1); Category IV, two masses with predominantly nonfatty component (n=3). Retroperitoneal dedifferentiated liposarcomas present various spectra of imaging findings. While Categories I and III may suggest dedifferentiated liposarcoma, Categories II and IV may appear as other types of liposarcoma or other malignant retroperitoneal tumor.Clinical imaging 01/2010; 34(3):203-10. · 0.73 Impact Factor
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ABSTRACT: To evaluate the characteristics of highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis. The clinical and radiological characteristics of 18 cases of highly malignant soft tissue sarcomas of the extremity with a delayed diagnosis were determined. Ten men and eight women of mean age 44.8 years (range, 15-79 years) were included in this study. Seven cases of synovial sarcoma, three cases each of alveolar soft part sarcoma and malignant fibrous histiocytoma, two cases each of highly malignant leiomyosarcoma and myxofibrosarcoma, and one case of clear cell sarcoma were enrolled. Times from tumor detection to diagnosis ranged from 1 to 3 years in most cases; three of the seven synovial sarcoma cases took more than 10 years to diagnose. Of the seven cases of synovial sarcoma, five cases of small, superficial located masses were simply excised without a pre-surgical biopsy. Three cases of alveolar soft part sarcoma showed characteristic T1- and T2-weighted high signal intensities with signal voids in MR images. In addition, one synovial sarcoma patient and one alveolar soft part sarcoma patient showed evidence of calcification on plain radiographs. However, no general characteristic clinical findings were found to be common to the 18 cases. Contrary to general expectations, some soft tissue tumors that grow slowly are painless, and those that occur in superficial limbs may be highly malignant. Thus, even when a slow growing, painless superficial mass is encountered in a limb, physicians should keep the possibility of highly malignant soft tissue sarcoma in mind.World Journal of Surgical Oncology 01/2010; 8:84. · 1.09 Impact Factor
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ABSTRACT: Biomarkers play a key role in risk assessment, assessing treatment response, and detecting recurrence and the investigation of multiple biomarkers may also prove useful in accurate prediction and prognosis of cancers. Immunohistochemistry (IHC) has been a major diagnostic tool to identify therapeutic biomarkers and to subclassify breast cancer patients. However, there is no suitable IHC platform for multiplex assay toward personalized cancer therapy. Here, we report a microfluidics-based multiplexed IHC (MMIHC) platform that significantly improves IHC performance in reduction of time and tissue consumption, quantification, consistency, sensitivity, specificity and cost-effectiveness. By creating a simple and robust interface between the device and human breast tissue samples, we not only applied conventional thin-section tissues into on-chip without any additional modification process, but also attained perfect fluid control for various solutions, without any leakage, bubble formation, or cross-contamination. Four biomarkers, estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), progesterone receptor (PR) and Ki-67, were examined simultaneously on breast cancer cells and human breast cancer tissues. The MMIHC method improved immunoreaction, reducing time and reagent consumption. Moreover, it showed the availability of semi-quantitative analysis by comparing Western blot. Concordance study proved strong consensus between conventional whole-section analysis and MMIHC (n = 105, lowest Kendall's coefficient of concordance, 0.90). To demonstrate the suitability of MMIHC for scarce samples, it was also applied successfully to tissues from needle biopsies. The microfluidic system, for the first time, was successfully applied to human clinical tissue samples and histopathological diagnosis was realized for breast cancers. Our results showing substantial agreement indicate that several cancer-related proteins can be simultaneously investigated on a single tumor section, giving clear advantages and technical advances over standard immunohistochemical method. This novel concept will enable histopathological diagnosis using numerous specific biomarkers at a time even for small-sized specimens, thus facilitating the individualization of cancer therapy.PLoS ONE 01/2010; 5(5):e10441. · 3.53 Impact Factor
- Journal of The Korean Surgical Society - J KOREAN SURG SOC. 01/2010; 78(3).
Article: Intense accumulation of 18F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors.[Show abstract] [Hide abstract]
ABSTRACT: Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [(18)F]-2-fluoro-2-deoxy-D-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.Annals of Nuclear Medicine 10/2009; 23(10):887-9. · 1.41 Impact Factor
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ABSTRACT: Mesonephric rests or mesonephric remnants are vestiges of embryonic structures called mesonephric (wolffian) ducts. It usually can be seen in the lateral wall of the cervix uteri. In males, the mesonephric remnants are seen in epididymis and efferent ductules. Prostate is one of the rare locations, on which the mesonephric remnants can be found. Hyperplasia of mesonephric remnants of prostate is rare but important because sometimes it is difficult to differentiate from adenocarcinoma. The lesion is important in the differential diagnosis from the high grade prostatic intraepithelial neoplasia. Here, we report an additional case of mesonephric hyperplasia, epididymal type, in a 66-year-old man. Microscopically, it showed tubular structures lined by columnar cells with pseudostratified elongated hyperchromatic nuclei. The cells showed negative reaction on high molecular weight cytokeratin and prostate-specific antigen immunostain.Basic and Applied Pathology 04/2009; 2(2):69 - 71.
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ABSTRACT: Background and aims: CXC chemokine receptor 4 (CXCR4) is an important factor in the migration, invasiveness, metastasis and proliferation of various carcinomas. EGFR plays an important role in regulation of cell proliferation and differentiation, cell-cell interaction and cytokine signaling. Several studies suggested that EGFR enhances the expression of CXCR4 through PI3K/Akt signal pathway. We evaluated the correlation and prognostic impact of CXCR4 and EGFR in non-small cell lung carcinomas (squamous cell carcinoma and adenocarcinoma). Methods: Analysis of 101 cases of non-small cell lung carcinoma was undertaken using tissue microarray technology and immunohistochemistry. Results: Moderate to strong nuclear or cytoplasmic CXCR4 expression of more than 20% of tumor cells and strong membranous EGFR expression of more than 10% of tumor cells were judged to be positive. Associations between CXCR4 and EGFR expressions and clinicopathologic features, including tumor stage, tumor size, nodal status, presence of metastasis, Ki-67 labeling index and disease free survival (DFS) were investigated with statistical analysis. In the patients with squamous cell carcinoma, CXCR4 expression was correlated with presence of metastasis (P= 0.040) and EGFR expression was correlated with presence of metastasis (P= 0.017). But in the patients with adenocarcinoma, no statistical correlation between CXCR4 and EGFR expressions and clinicopathologic parameters was found. In the patients with squamous cell carcinoma, CXCR4 and EGFR positive groups showed significantly shorter DFS than negative groups (P= 0.033 and 0.038, respectively). Conclusions: CXCR4 expression is a significant prognostic factor in non-small cell carcinoma, especially squmous cell carcinoma. Well designed, larger studies on CXCR4 and EGFR expressions will be needed to confirm their significances.Basic and Applied Pathology 11/2008; 1(4):189 - 195.
Top Journals
Yonsei University Hospital
Seoul, Seoul, South Korea
- • Surgery
- • Department of Internal Medicine
Weill Cornell Medical College
New York City, New York, United States
- Department of Surgery
Sungkyunkwan University
Seoul, Seoul, South Korea
- • School of Pharmacy
- • Department of Electronic, Electrical and Computer Engineering
Inje UniversityKŭmhae, South Gyeongsang, South Korea
University of Bath
Bath, ENG, United Kingdom
- Department of Electronic and Electrical Engineering
Chonbuk National UniversityTsiuentcheou, North Jeolla, South Korea
Korea University
Seoul, Seoul, South Korea
- • Department of Pathology
- • Department of Pediatrics


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40, South Bend, INWriter with a great job at Ave Maria Press. Love Jane Austen and baseball. No, that's not a contradiction. Hiking. Travel. Reading. Try to be a good, divorced dad. Fail someti...
30, Mishawaka, INWell, I'm a graduate student at Notre Dame, studying physical chemistry. Overall, I think that I'm pretty easy to get along with. I try to look at the positive side of life ...
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37, Mishawaka, INTraditional Roman Catholic, look forward to heaven. The saints are influential in my life. Enjoy praying, walking, talking to friends, reading, enjoying nature, music.
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The Last Crown – New Screens
Wednesday, December 5th, 2012
by GL News
by GL News
Those hanging on for more news of the long-awaited release The Last Crown from British horror master Jonathan Boakes will be pleased to know that a new raft of screenies have been released. Creepy locations, check. Sinister atmosphere, check. New underwear on standby, check.
Ninja Gaiden 3 - E3 Preview
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Last updated: 05/26/2011 11:00:00 AM
It's late at night I broke into your COCK!!!!
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And when I'm through with you I'll have your daughter WITH MY COCK
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Forever etched in your mind... this horrible scene
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When you crossed the line... you paid the cost
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Ready to unleash my perverse Hell
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Lusting for her flesh! NAD MY COCKKKKKKKKKKKKKKKKKKKKKK
Thanks to Nathan Stange for submitting Rape Lyrics.
thats quite intresting | Reviewer: Anonymous | 9/29/2007
you are kool guy
but u need to relax
go on a vacation maybe the bahamas or hell or halo or atlantis or the bermuda triangle... u no somewhere nice
you are kool guy
but u need to relax
go on a vacation maybe the bahamas or hell or halo or atlantis or the bermuda triangle... u no somewhere nice


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Some information is missing or invalid below.
Eddie Bauer 4-pc. Teddy Bear Crib Set
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Eddie Bauer crib set are unbearably cute! Featuring teddy bear graphics, this Eddie Bauer crib set makes an adorable decor for your little cub's nursery. In brown/multi.
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Jonathan Morris is on a mission to create a better grooming experience for men.
With its economic development engine revving at full throttle, Southlake is about to welcome several major retail and commercial projects that underscore its image
"I've always been a maverick in a number of ways," says businesswoman and philanthropist Stacie McDavid.
Thousands of people rallied late Monday in U.S. cities including Los Angeles and New York to passionately but peacefully protest a grand jury's decision not to indict a white police officer who killed a black 18-year-old in Ferguson, Mo.
WASHINGTON — It may house some of the most esteemed colleges in the country, but if you want to graduate without backbreaking debt, steer clear of schools along
A. Lee Graham
Saks Fifth Avenue Off 5th unveils its newly remodeled store at Grapevine Mills Mall on Friday May 10, 2013.
The store, as well as a location in Milpitas, Calif., has been remodeled in the company's "luxury-in-a-loft" design, featuring a modern, uncluttered layout with an open floor plan, moveable fixtures and bright lighting.
"We look forward to offering customers of both communities a deluxe shopping environment with a great selection of designers, the latest fashion and high-quality merchandise at an extraordinary value," said company president Robert Wallstrom, commenting in a news release.
Three Saks Fifth Avenue Off 5th stores operate in the Dallas-Fort Worth area, including at Grapevine Mills, with neighboring stores in Grand Prairie and Dallas.
The approximate 35,000-square-foot store in Grapevine features designer and contemporary brands available at outlet prices, including women's and men's apparel, fine jewelry, handbags, shoes and children's collections.
In celebration of the renovated stores, Saks Fifth Avenue Off 5th has partnered with Style for Hire, a national network of personal stylists handpicked by Stacy London, host of The Learning Channel's What Not to Wear, to offer in-person consultations and on-demand shopping advice at the stores' launch party on Thursday May 9.
During the launch party, 5 percent of Thursday evening's sales will benefit Dress for Success Dallas and San Jose, a nonprofit organization that promotes the independence of disadvantaged women by providing professional attire, a network of support, and the career development tools to help women thrive in work and in life.
More information is available at www.off5th.com.
< back


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Written on: 14/02/2014
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Jul 4, 2012
U.S. Customs and Border Protection and the trading community use the HTS to determine tariff classifications and duty treatment for goods imported into the United States
page 1 of 1
The USITC has released A Guide to the Harmonized Tariff Schedule of the United States, a web- based, interactive e-learning module to help users become familiar with and learn how to read the Harmonized Tariff Schedule of the United States.
The e-learning module, originally developed as an in-house training tool for new USITC staff, will guide users through web-based lessons to help them understand the HTS and how it is structured. The USITC fields hundreds of calls a year from importers, businesses, and citizens seeking information about classifying merchandise in the HTS.
U.S. Customs and Border Protection and the trading community use the HTS to determine tariff classifications and duty treatment for goods imported into the United States. The USITC plays a unique role in maintaining the HTS. The USITC also advises the United States Trade Representative and the Congress about proposals that might modify any or all of the thousands of product categories and duty rates.
The USITC HTS e-learning module consists of four lessons, which provide information about:
Each lesson includes a review section to ensure users have accurately digested the lesson's information.
The e-learning module also includes useful resources and links to other relevant information, including a glossary of terms, a library of links to related or more advanced information on a number of the topics covered in the lessons, and the HTS itself.
The USITC welcomes feedback on the HTS e-learning module from users at firstname.lastname@example.com.
• La BEI et la Métropole Nice Côte d'Azur signent un contrat de 250M€• Imparten IMPI y EPO seminario para Centros de Patentamiento• University of Louisville Signs 10-Year Extension with CLC• Amerlux FINO ceiling wins product innovation award• Supernus sues Zydus for infringement of Trokendi XR(R) patents• 4 Commissioners from Team Juncker joined the 6th European Innovation Summit• Historic deal on new rules a breakthrough for tackling plastic waste• Google v. Vederi• Se inauguran las Jornadas Expo Ingenio Yucatán 2014• Mattersight granted additional U.S. patent for predictive behavioral routing


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Home > Sport > Tennis
Tuesday February 18, 2014 MYT 4:12:01 AM
Tuesday February 18, 2014 MYT 4:12:39 AM
BUENOS AIRES (Reuters) - Juan Martin del Potro said on Monday he will not play in Argentina's Davis Cup playoff tie in September due to his differences with the Argentine Tennis Association (AAT).
Argentina, who have reached four finals - including three since 2006 - must play off against as yet unknown opponents to retain their world group status having been upset by Italy in the first round in Mar del Plata two weeks ago.
"It's necessary to make deep changes to correct mistakes that have been repeated for so many years," said world number five Del Potro, who does not see eye-to-eye with team captain Martin Jaite.
Del Potro also reacted to rumours and erroneous reports after the Italy defeat suggesting he would only play for Argentina under certain conditions.
"I won't permit my name to be used to justify resignations that will only paper over the cracks. I never asked for a (specific) captain and always respected others' decisions even if they didn't respect me," he said in a letter to the AAT.
"Out of consideration for the people who follow me, who enjoy tennis... and know what I've done in the Davis (Cup) and Olympic Games... and are a long way from insulting rivals or punishing someone from their country, I won't play the Davis Cup for the rest of 2014."
Del Potro, Olympic bronze medal winner at the 2012 London Games, has been unhappy with attitudes towards him from some corners of the AAT and media since being made a scapegoat for Argentina's unexpected defeat in the 2008 final at home to a Spain team missing Rafael Nadal.
The 2009 U.S. Open champion dislikes the soccer-type support from sections of the crowd at home matches who question players' commitment to the team if they put their careers on the ATP circuit first, failing to accept their prerogative to do so.
AAT president Arturo Grimaldi said he was surprised by Del Potro's letter and would like to know what his grievances are.
"I'd like to get together with Del Potro and talk with him. People forget what he's done for Argentina," Grimaldi told TyC Sports. "There must be a failing on our part."
Del Potro last played for Argentina in their Davis Cup semi-final loss at home to the Czech Republic in Buenos Aires in 2012. He opted out last year when Argentina also lost to the Czech holders away in the semi-finals.
Argentina reached the final in 1981 thanks mainly to Guillermo Vilas but were defeated away by the United States.
In recent years they have relied heavily on the now retired David Nalbandian but lost the 2006 final to Russia in Moscow and the 2011 final again to Spain in Seville.
(Reporting by Luis Ampuero; Writing by Rex Gowar in London, Editing by Ken Ferris)
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Federer suffers another Basel final loss to Del Potro
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Former champion Del Potro passes tight first test
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Returning Rafa ready to roll once again
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Copyright © 1995-2014 Star Publications (M) Bhd (Co No 10894-D)


text:
Look at our boy Shyne talk about the responsibility he has with the young minority community and the destruction he contributed to.He has some valid points… and the way Po is popping off at Rick Ross and Diddy does not sound politically correct!
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You can win a 65-inch 3D-ready TV, media server and more by entering Mitsubishi's sweepstakes over the next month.
Product News · Blu-ray · 3D · Manufacturer · Mitsubishi · DLP · Sweepstakes · Nvidia · Aspen · All topics
The Aries serves as a bridge between the lossless online streaming service and a DAC.
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The sensor network can monitor changes in moisture, temperature and humidity.
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Thomas's Commitment is Solid
With others in the ACC and SEC still pursuing, 2013 RB Khalid Thomas is committed to Kentucky.…
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300 Bulgarian Rangers Leave for Afghanistan
Bulgarian state officials will see off on Tuesday a unit of 300 rangers to Afghanistan, who will guard the interior zone at the Kandahar Airport
Bulgaria's former government adopted in mid-January a long anticipated decision to terminate partly the Bulgarian military mission in the NATO-led ISAF forces in Afghanistan.
The decision came in accordance with strategy for transformation of Bulgaria's participation in the ISAF mission in Afghanistan, which was approved by the government at the end of 2011, following a decision by the USA under President Barack Obama's plan for a major withdrawal from Afghanistan by 2014.
Bulgaria's military presence in Afghanistan initially consisted of 530 rangers, and was later boosted to 600.
By the end of 2014 Bulgaria will continue to maintain its security company guarding the interior zone at the Kandahar Airport as well its teams of advisers to the local security forces.
After 2014, Bulgaria will continue its participation in NATO's mission in Afghanistan only with teams of advisers stationed on the ground with the Afghan security forces and the local authorities.
- » Bulgarian Soldiers to Depart for NATO's New Mission in Afghanistan
- » Bulgaria Hosts Int'l Conference on Ukraine, Middle East
- » NATO Claims Russian Military Convoys Enter Ukraine
- » NATO's Europe Commander to Meet Bulgaria DefMin, Chief of Defense
- » Bulgaria's New DefMin to Start Revision at Ministry over 'Abuses'
- » Defence Minister Asks For Security Council Meeting To Discuss IS


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Amisha Patel at a toy store launch
Praful Patel to come to Delhi to meet Ahmed Patel
BJP leaders remember Patel
Kiss Of Love
BJP: Need to spread Sardar Patel's positive message
Director Bala Kissing Pooja
Discussion On Kiss Of Love
Ameesha Patel Bids Goodbye To Lord Ganesha
BJP candidate Anupriya Patel sit on a Dharna
Latur Pasha Patel Ordered To Fight Election By Bjp
Bigg Boss 8 : Who is Upen Patel ?
Sardar Patel's birth anniversary to be Rashtriya Ekta Divas
PM Modi wishes Patel's birth anniversary on Twitter
Has history been unkind to Sardar Patel?
Rajpath turns into 'Patel'path today
Shazahn Padamsee Talk About 'Meet The Patels'
Emraan Hashmi's Goodbye Kiss
Happy Ending Official Trailer
First Look: Sunny Leone as 'Leela'
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Aamir Khan Wants To Play Circuit In


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Courtyard Seattle Bellevue/Downtown
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
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To mark IDC Herzliya's 20th anniversary, we spent a day following Prof. Uriel Reichman, IDC's founder and president, and Jonathan Davis, VP for External Relations, around its delightful campus.
Iraq, the country that the Bush Sr. administration made safe for democracy, lost 49 more citizens and soldiers the past two days with 10 car bombs on mostly Shi'ite Muslims and suicide bombings of a group of soldiers.
Another 100 people suffered injuries as violence returns to the hey-day of 2008, when American troops were working with the Iraqi government and training it soldiers to keep law and order.
Two of Sunday morning's bombs were in a busy market in the town of Nahrawan, south of Baghdad, and were presumably carried out by Sunni Muslim terrorists, possibly with the help of Al Qaeda, the terrorist organization that President Barack Obama two years ago said was on the verge of being wiped out.
Approximately 3,000 Iraqi civilians have been killed this year.
About the Author: JewishPress.com brings you the latest in Jewish news from around the world. Stay up to date by following up on Facebook and Twitter. Do you have something noteworthy to report? Submit your news story to us here.
If you don't see your comment after publishing it, refresh the page.
When will people realize the a 'government of the people' has to come from those people and not from outside forces.
Help team-write the next Tom Clancy best selling Spy Thriller: Why USA needs a Saudi/FBI terror sting bomb factory? Think rat/roach bait? https://draftin.com/documents
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The Kinneret rose 3.5 centimeters overnight due to the heavy rainstorm that hit the country.
The father-son team recently gave a check to the family of Druze policeman Zidan Saif for his role in stopping the Har Nof Massacre.
The police fought hard to not have it revealed that Netanel Arami was murdered in a Petach Tikva terror attack, but now a court has lifted the gag order…
The three were walking along the side of the highway when the accident happened.
A device, a gas canister with wires, was left near the Shavei Shomron intersection this morning, designed to look like a bomb.
The ISIS 'prince' of Iraq's Anbar province was killed in a US-led coalition air strike Wednesday.
The Ferguson-related unrest continued across America Tuesday night. Some blamed Israel.
Israeli MK Yuli Edelstein tells Chabad rabbis why he "lost it" over tefillin in a Soviet labor camp.
Turkish legislator proposes Turkey pass law naming Israel a terrorist state.
ISIS reportedly executes by stoning two allegedly gay males in Syria.
World Council of Arameans Now "Looks Specifically to Turkey, Iraq, Syria, and Lebanon"
Young Israeli women arrive at the Malcha Mall in Jerusalem to donate their hair to create wigs for cancer patients at a fundraiser arranged by "Zichron Menachem", the Israeli Association for the Support of Children with Cancer and their Families (November 24, 2014). All photos by Gershon Elinson/Flash90
In Lebanon, a pro-Hezbollah vocalist has been arrested for nationalist and sectarian incitement.
Thousands attended a Jerusalem memorial service to mark the end of seven days' mourning for five terror victims.
The European Parliament decided Tuesday to postpone till December its decision on recognizing 'Palestine' as a new country.
An ISIS-linked group calls for lone wolf attackers to use the Ferguson riots in America as cover for their activities.
The Kinneret rose 3.5 centimeters overnight due to the heavy rainstorm that hit the country.
The father-son team recently gave a check to the family of Druze policeman Zidan Saif for his role in stopping the Har Nof Massacre.
The three were walking along the side of the highway when the accident happened.
A device, a gas canister with wires, was left near the Shavei Shomron intersection this morning, designed to look like a bomb.
Originally the police claimed it was a fight between Arabs and Jews, and not a terror attack.
MK Tzipi Hotovely (Likud) will be receiving additional security protection.
A major rainstorm is expected to hit Israel overnight. Batten down the hatches
Bystanders caught on video the police arresting one of the suspects in the Old City stabbing.
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The Ringgold Tiger Sharks improved to 4-2 in the Chattanooga Area Swim League's Red Division following a 447-284 victory over the Red Bank Gators on Wednesday in a makeup meet.
Emma Pulliam, Evan Wingrove and Jon Lancaster all had the maximum 19 points for Ringgold while Dallas Woods had the same total for the Gators.
Red Bank will conclude its regular season with a meet in Cleveland against the Waterdogs on Monday while Ringgold's season will end with a meet at Country Club on Tuesday.
Both teams will be involved in the annual City Meet on July 11-12 at Warner Park.
19 -- Emma Pulliam, Evan Wingrove, Jon Lancaster
18 -- Tori Rhinehart
17 -- Regan Wingrove, Sarah Beth Moore, Will Gurley, Kale Davis, Gabriel Johnson
16 -- Evan Moeller
15 -- Will Riddell
14 -- Daniel Patouga, Easton Odonnell, Hardy Jones
13 -- Alex Van Alstine, Pierce Lively, John Courtney
12 -- Isabella Sweat
11 -- Saulye Nichols, Rylee Odonnell
10 -- Lindsay Hudson, Tim Grayson
19 -- Dallas Woods
17 -- Amelia Harris
15 -- Michaela Massey
14 -- Conner Boerschig
13 -- Luke Massey, Chase Garner, Catherine Lynch, Macie Meyners
11 -- Kate Schlegel
10 -- Linsy Devlin
(Email John Hunt at firstname.lastname@example.com)
November 26, 2014
Football is the traditional sport during Thanksgiving, but for Mocs fans it will be basketball, basketball and more basketball the next two days at McKenzie Arena. The UTC men host three ... (click for more)
The final week of the SEC's regular season is here. Both divisional titles are still up for grabs, and for some teams, (Tennessee) a win is needed to avoid packing up the gear until spring practice ... (click for more)
A member of the College of Sports Information Directors Association's Hall of Fame, a man who had one of the longest streaks working college football games and a writer who covered Tennessee's ... (click for more)
Football is the traditional sport during Thanksgiving, but for Mocs fans it will be basketball, basketball and more basketball the next two days at McKenzie Arena. The UTC men host three other teams in the Battle 4 Atlantis Mainland tournament, while the UTC women have a much anticipated game with undefeated and No.5 Tennessee. Wednesday – UTC Men Battle ... (click for more)
The final week of the SEC's regular season is here. Both divisional titles are still up for grabs, and for some teams, (Tennessee) a win is needed to avoid packing up the gear until spring practice in 2015. Last week: 7-1 Year to date: 83-18 Georgia Tech at Georgia: The Bulldogs are playing their final regular season game of the year, counting on the red-hot ... (click for more)
Police said a dispute over a card game led Ladaquis Dewartae Southers to shoot Terrence Bivens multiple times. Southers has been returned to Hamilton County to face a charge of criminal homicide. Police said Bivens was a validated Athens Park Blood gang member and Southers is in the Bounty Hunter Blood gang. In the incident on Oct. 27 just before 4 a.m., police responded ... (click for more)
A post-conviction hearing in which Marlon Duane Kiser is seeking a new trial in the 2001 slaying of Deputy Donald Bond will resume April 6. Attorneys for Kiser, who is on Death Row, said they have additional witnesses to call. Kiser on Tuesday took the witness stand for the first time, blaming the killing on the man he was living with at the time - Mike Chattin. Chattin, who ... (click for more)
The recent verdict in Ferguson has thrown race relations in the spotlight again. It is far too easy to get caught up in the debate as to who was right. But the plain fact is that the community lost, the police force lost and the nation lost. So why does Ferguson matter in Chattanooga? Because a police force mainly composed of whites got into a conflict with a community mainly ... (click for more)
I'm not really sure how it all came about but a few days before Thanksgiving last year, what was usually a crowded table had dwindled down to just Mother, Aunt Martha and me. Just the idea of getting dressed up made both of them tired, which happens when you are 89 and 87, respectively, and the thought of preparing the traditional feast brought only further groans so I announced ... (click for more)


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Grace Edmondson will finish out her senior season in blue and white with the Vardaman Lady Rams but will be wearing black and gold next season as a Lady Tiger at Northeast Mississippi Community College in Booneville.
Edmondson signed a letter of intent with NEMCC March 26 accompanied by her family members and VHS coaches.
"I think they've got a nice program and it seemed like a good fit for me," Edmondson said.
Coach Billy Dill believes Edmondson will be an asset to the NEMCC program just as she has been for VHS.
"She's pitched for three years and has progressed tremendously over the years," Dill said. "She's a leader on the team and gets stronger each year. She just keeps on getting better."
Edmondson is an honor student at VHS but said she has not yet decided on a college major.
"She's an honor student, smart, very coachable, just a great kid," Dill said.
Edmonsdon will join former VHS teammate, Whittney Gee, who transferred to NEMCC after the fall semester.
Edmondson heads to Tiger land
Grace Edmondson will finish out her senior season in blue and white with the Vardaman Lady Rams but will be wearing black and gold next season as a Lady Tiger at Northeast Mississippi Community College in Booneville.
About Lisa Voyles
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- Trustees, judges on ballot November 24, 2014
- Chieftains to stand tall on court November 24, 2014
- Houston ready for tipoff and tournament November 23, 2014
- A golfer's tale November 23, 2014
- BILLY McCORD: As I see it November 23, 2014
- Kathryn: I'd say that Mr. Scott nailed it. Well said, sir...
- Erma Byars: Congratulations Marty for all your achievements. ...
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Author, Miranda Parker
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Author of The Evangeline Hunter Bounty Series, Miranda Parker, discusses her novel, "A Good Excuse to Be Bad".
Beltway Series, Freeway Series or I70 Series
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Which regional 2014 World Series is the most desired as the 2014 MLB Playoffs unfold? Is it the Beltway Series, the Freeway Series or the I70 Series? The core show panelists will discuss theirs'. We will also have week 5 of the NFL and examine the biggest surprises and disappointments of the 1st quarter of the 2014 NFL regular season. College football week 6 highlighting Stanford-Notre Dame, Texas A&M-Mississippi State and others. We will also celebrate a positive trend in the world of sports involving the inspirational 2014 Kansas City Royals plus much, much more.
Preview and Predictions of Survivor Series PPV 2014
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In the RETURN of " Steve's Wrestling Ramble " , i shall be going over and giving my predictions for the Survivor Series PPV here in 2014 . I think that this PPV can be better than other think and people can view it for FREE on the WWE Network . I will go match by match and give my thoughts on things could go and other things as well . IF want to be on the show , welcome to call in at any time . Twitter handles are as follows : @ARMY_STRONG_06 and @WWE_Podcast .
The Wrestling Debate: WWE Survivor Series Preview
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The Survivor Series is acouple of days away and the balance of power in the WWE could change in the matter of 1 match. On 1 side we will be Team Authority led by captain Seth Rollins and on the other side is Team Cena led by John Cena. If Team Cena wins then The Authority is done for. On tonight's show join John,Billy,and friends as we pick our winners and losers for the big match as well as all the other matches. Want to chime in and give your predictions? (323)870-4022 is the number. Call in and talk the Survivor Series with us.
The 2014 World Series
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With each team winning two games, we're down to a best-of-three championship series. Game 5 is pivotal for both teams; however, it's the final stand at home for the Giants. Rest assured, they'll be aiming to continue riding their Game 4 momentum. The Royals, on the other hand, need to bounce back in a big way to quickly stop the bleeding.Both of these clubs have now gone through their entire pitching rotations. Starters Madison Bumgarner and James Shields will take the mound for the second time in this series, and they'll have their work cut out for them against lineups that combined for 28 hits Saturday evening. the Bleacherreport
The takeaway here isn't how things can go so wrong as much as it is the Royals' remarkable ability to keep things so right over the last month.
"Most nights we do a pretty good job doing it," Yost says. "It just didn't work tonight."The Royals are two wins from a world championship because they've kept the trains running on time. Losing game four is more of a reminder of the infrastructure they need in place to celebrate. Sam Mellinge Kansas Star
With apologies to the stats crowd, an all-wild-card World Series has to have an element of pluck. Who outgrinds whom? Were it completely about talent, these two teams would have won their divisions, no?With their bid for another championship slipping from their grasp in Game 4 Saturday night, the Giants channelled whatever fortitude they could muster and tied the World Series at two wins apiece when they rallied from three runs down and steamrolled the Royals 11-4. Michael Macor The Chronicle
The Right Side of the Pond - Survivor Series Preview
in Wrestling
This week Maverick, Shinobi and Mazza are back again to discuss WWE's Survivor Series on Sunday. With a rather small undercard, they look at who they think Fandango's mystery opponent will be. They give their thoughts on the stuttering Ambrose vs Wyatt feud and then take a good look at the main event on the night. There are insane Maz theories all over the place as they work out ways WWE may back themselves out of the corner they seem to have backed themselves into.
The ER Report - Episode #31 (WWE Survivor Series Prediction Show)
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On episode 31 of The ER Report, Eron Ramadanov talks about WWE Survivor Series, as he picks his winners, losers, and more. Eron will also cover WWE's 100 matches to see before you die list, spotlight segment, and more!
World Series Preview
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NFL Week 7; NBA Preseason; MLB World series 2014 preview; WWE
The Wrestling Debate: WWE Survivor Series talk & More
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With Survivor Series 2 weeks away the pressure is on John Cena and The Authority to make winning teams. Join John Billy and friends as we preview the big match with so much on the line. We will also talk about NXT wrestlers Hideo Itami and Finn Balor and do they belong in NXT or should they be brought up to the main roster. If you have anything you would like to chime in on the phone line is (323)870-4022. Join us as we talk wrestling and more.
Troy's World Series Preview
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Hello baseball fans! The 2014 World Series starts tomorrow. Tune in as dad and I preview the San Fransisco Giants/Kansas City Royals World Series matchup. It should be an interesting series.
HTC Wrestling Pulsecast: Survivor Series Preview & Our Personal Dream Teams
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Justin Czerwonka, Matt Harrak & Heather Miller preview the 2014 WWE Survivor Series, gives their predicitions and present their own "dream" 5-man Survivor Series team.
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Join Diva Taunia every Monday for a lunchtime music concert series (NOON PST), featuring some of today's up and coming musicians, artists and songwriters. If you like what you hear, we encourage you to stop by their website or social media pages and let them know! All links can be found on the blog at www.divatauniablog.com . Our artists this week:
1. Blu Collar Glomeration with "Rooster"
2. Randy Myers with "Miss My Baby"
3. Kevin Reeves with "Brokenhearted Man"
4. Chinedu Gboof and Ingrid Phillip with "Father"
5. Alexander Ehm/Jennifer Pederson with "Oh My Lord and Savior"
6. Solobeats featuring Keyzpleyer with "The Way You Make Me Feel"
7. Diva Taunia with "This Can't Be Love"
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Pilot Tool Aims to Ready Countries for Private Sector Investment in Sustainable Energy
November 24, 2014 – A pilot tool launched by the World Bank Group will help developed and developing countries further their sustainable energy goals by providing a snapshot of the policy and regulato... Show More +
Myanmar: Farmers' Profits Lost Due to Volatile Rice Prices
Investments needed in agricultureThe harvest season is the only time of the year when the Shwe Ryae Rice Mill can work on full speed. The 120-year-old wooden mill still runs on a steam engine. Accordi... Show More +
Global Agriculture and Food Security Program Announces $107 Million in Grants to Fight Hunger and Poverty
WASHINGTON, November 24, 2014—Partners in the Global Agriculture and Food Security Program (GAFSP) today announced $107 million in grants to five countries−Benin, Bhutan, Kenya, Laos PDR, and Timor Le... Show More +
Future Impact of Climate Change Visible Now in Yemen
Yemen today is a glimpse of what's in store for other parts of the Middle East and North Africa (MENA) as climate change and rapid population growth combine to put more and more pressure on the resour... Show More +
Can Tho, Vietnam: Enhancing Urban Resilience
November 24, 2014A CityStrength Diagnostic was conducted in Can Tho, Vietnam in June 2014 at the request of the city. A team of specialists from the World Bank Group worked with local officials, techn... Show More +
Climate Change to Bring More Heat Waves and Water Shortages in the Middle East and North Africa
WASHINGTON, November 23, 2014— In a world where global average warming reaches 4°C above pre-industrial level, summer temperatures are expected to be up to 8°C warmer in parts of Algeria, Saudi Arabia... Show More +
Rice Price Volatility and Poverty Reduction In Myanmar
RecommendationsA good diagnostic assessment of the actual situation is needed in order to differentiate harmful volatility from normal price volatility. Due to the seasonal nature of rice production a... Show More +


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June 9, 2014 - Actor TAYE DIGGS, from the new TNT series "Murder in the First," joins Kelly as co-host today. Rap artist and actress NICKI MINAJ speaks about her new album, "The Pink Print," and Kelly and Taye chat with "Mythbusters" stars ADAM SAVAGE and JAMIE HYNEMAN. Plus, singer-songwriter COLBIE CAILLAT performs for the "LIVE" audience.
June 10, 2014 - Kelly's co-host this morning is three-time Emmy Award winner JIM PARSONS, and "How to Train Your Dragon 2" star KIT HARINGTON stops by. In addition, the hosts interview "Jersey Boys" star JOHN LLOYD YOUNG, and animal ambassador Rick Schwartz brings along some fun critters from the San Diego Zoo.
June 11, 2014 - ANDERSON COOPER is Kelly's co-host today, and they speak with Golden Globe winner America FERRERA about the new film "How to Train Your Dragon 2." Plus, the hosts meet the newly-crowned MISS USA, and 18-time Grammy Award winner ARETHA FRANKLIN performs for the "LIVE" audience.
June 12, 2014 - ANDERSON COOPER returns this morning as Kelly's co-host, and they sit down with Oscar®-nominated actor LAURENCE FISHBURNE from the new film "The Signal." In addition, actress TAYLOR SCHILLING talks about the new season of "Orange is the New Black," and country singer MARTINA McBRIDE performs for the "LIVE" audience.
June 13, 2014 - Kelly's husband, MARK CONSUELOS, wraps up the week as co-host, and they chat with "How to Train Your Dragon 2" star GERARD BUTLER. Plus, singer-songwriter JOSH GROBAN discusses the new ABC competition series "Rising Star," and "LIVE's Superstar Chefs Farm-to-Table Challenge" continues with French chef ERIC RIPERT.
"LIVE with Kelly and Michael" is distributed in national syndication by Disney-ABC Domestic Television. Produced by WABC-TV in New York and executive produced by Michael Gelman, "LIVE" airs in more than 200 markets across the U.S. Visit "LIVE" on the web at LIVEKellyandMichael.com, on Facebook, or follow "LIVE" on Twitter and Instagram, @KellyandMichael.
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Quadrature Error Bounds With Applications To Lattice Rules (1996)
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|SIAM J. Numer. Anal
|26 - 6 self
author = {Fred J. Hickernell},
title = {Quadrature Error Bounds With Applications To Lattice Rules},
journal = {SIAM J. Numer. Anal},
year = {1996},
volume = {33},
pages = {1995--2016}
Years of Citing Articles
. Reproducing kernel Hilbert spaces are used to derive error bounds and worst-case integrands for a large family of quadrature rules. In the case of lattice rules applied to periodic integrands these error bounds resemble those previously derived in the literature. However, the theory developed here does not require periodicity and is not restricted to lattice rules. An ANOVA decomposition is employed in defining the inner product. It is shown that imbedded rules are superior when integrating functions with large high order ANOVA effects. Key words. ANOVA decomposition, good lattice points, imbedded rules, multidimensional integration, Monte Carlo, number-theoretic, quasirandom, periodic functions, reproducing kernel Hilbert spaces AMS subject classifications. 65D30, 65D32 1. Introduction. Many multidimensional integrals can be written as I(f) = Z C d f(x) dx; where C d = [0; 1) d is the d-dimensional unit cube. A simple approximation to I(f) is the arithmetic mean of the va...
Theoretic Methods in Statistics
- Number
- 1994
(Show Context)
Citation Context
...N . Quadrature rules based on rank-1 lattices (also called good lattice points) were proposed independently by Korobov [14] and Hlawka [10]. They have been studied by Hua and Wang [11], Fang and Wang =-=[6]-=- and others. Because integration lattices have period 1 in each coordinate direction, it is convenient to define f on R d by a periodic extension of its definition on C d . If f is Department of Mathe...
angenaherten berechnung mehrfacher integrale, Monatsh
- Zur
- 1962
(Show Context)
Citation Context
...is a generating vector normally chosen to be relatively prime to N . Quadrature rules based on rank-1 lattices (also called good lattice points) were proposed independently by Korobov [14] and Hlawka =-=[10]-=-. They have been studied by Hua and Wang [11], Fang and Wang [6] and others. Because integration lattices have period 1 in each coordinate direction, it is convenient to define f on R d by a periodic ...
lattice rules for multidimensional integration
- Imbedded
- 1992
(Show Context)
Citation Context
... +Gn )"C d consists of n 1 \Delta \Delta \Delta n d translated copies of the set S 0 . Quadrature rules based on S are called imbedded rules. Sloan and Walsh [26], Disney and Sloan [4], Joe and S=-=loan [13] and -=-Joe and Disney [12] studied imbedded lattice rules. They recommended choosing S 0 = L 0 " C d for some rank-1 lattice L 0 and choosing n j = 1 or 2. Their computations and theoretical results sug...
sequences and their discrepancies
- Quasi-random
- 1994
(Show Context)
Citation Context
...e as P ff . Furthermore the worstcase integrand, as constructed in [16, x2.2] does not have as simple a form as (1.5). Other error bounds, including those based on an L 2 discrepancy, may be found in =-=[15]-=-. The approach we use to derive new quadrature error bounds differs from those outlined above in that it is based on the theory of reproducing kernel Hilbert spaces. Unlike the standard error analysis...
Carlo methods with modified vertex weights
- Quasi-Monte
- 1993
(Show Context)
Citation Context
...drature rules with non-uniform weights, provided that the weights depend only on the points in S and not on the integrand. Some rules of this type have recently been studied by Niederreiter and Sloan =-=[18, 19]-=-. Acknowledgments. The author wishes to thank Kai-Tai Fang, James Lyness, Art Owen, Ian Sloan and two anonymous referees for valuable discussions and suggestions regarding this manuscript. The author ...
arrays for computer experiments, integration and visualization
- Orthogonal
- 1992
(Show Context)
Citation Context
...product on X it is convenient to consider analysis of variance (ANOVA) decompositions of functions in X. These decompositions have been used in the statistical literature by Efron and Stein [5], Owen =-=[20]-=- and others. Let D = f1; : : : ; dg be the set of coordinate indices. For any index set u ` D, let juj denote its cardinality. Let x u denote the juj-vector containing the components of x indexed by u...