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Wednesday, 10 Feb 2010 07:19 AM
Americans backed off from holiday spending in January, but retail sales rose for a third month in a row compared with a year earlier, largely because of gas price hikes, according to figures released Wednesday by a key data service.
Including goods from food to clothing to gasoline — but excluding cars — U.S. retail sales rose 3.6 percent from January 2009, according to MasterCard Advisor's SpendingPulse, which offer an estimate of spending in all forms including cash.
That increase followed a 4.8 percent gain in December and a 2.1 percent gain in November, according to SpendingPulse.
Excluding both gas and auto sales, retail sales rose 0.3 percent in January, 2.1 percent in December and 0.2 percent in November compared with a year earlier. The year-over-year figures are not seasonally adjusted.
"It is a modest pace of spending," said Kamalesh Rao, director of economic research for MasterCard Advisors' SpendingPulse. "Consumers are not going back to their caves, but they are not spending aggressively either."
With consumer spending — including major items like health care — accounting for 70 percent of U.S. economic activity, according to the government, economists watch it closely for clues on what lies ahead.
SpendingPulse's month-to-month figures — which are seasonally adjusted and include gasoline but exclude autos — show January's sales rising 2.8 percent from December's, which fell 1.9 percent from November's. November's sales rose 1.1 percent from October.
SpendingPulse released its data ahead of government figures coming Thursday and earnings reports due later in the month from major retailers like Wal-Mart Stores Inc. and J.C. Penney Co. that also will offer insight into consumers' behavior.
Economists surveyed by Thomson Reuters predict the U.S. Department of Commerce's sales index due Thursday, which excludes autos but includes gasoline, will be up just 0.5 percent in January from December.
Yet another forecaster, Scott Hoyt, senior director of consumer economics at Moody's Economy, estimates January sales rose 3.7 percent compared with a year earlier and 0.3 percent from December. He excludes autos from his estimates.
SpendingPulse's Rao says its figures offer a more nuanced snapshot than the government's because MasterCard uses purchase data from millions of shoppers.
Rao said shoppers generally pulled back on discretionary items like electronics, but did buy clothes, which was borne out in January figures released last week by apparel chains.
SpendingPulse estimates that women's clothing sales rose 2.7 percent and men's 2.5 percent in January 2010 from January 2009. In contrast, electronics sales rose only 0.4 percent and online sales growth slowed to 15.1 percent from 17.7 percent in December 2009.
According to a tally from the International Council of Shopping Centers, selected retailers' sales in stores open at least a year rose 3.0 percent in January from a year earlier. The figure was well above ICSC's forecast for a 1 percent gain.
ICSC's data includes primarily clothing sellers; it excludes autos, gasoline and building materials. After Wal-Mart Stores Inc., the world's largest retailer, stopped participating last year, the monthly figures released by individual stores became a better gauge of discretionary spending than the economy overall.
© Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Monday, 24 Nov 2014 17:18 PM
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Well...,it looks like we can anticipate the Ferguson Grand Jury decision this...
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Not a smidgeon of evidence . 30,000 emails from lois alone ion that time period...
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Nurse delegation: credentials and training verification 1. and is in good standing without should have a letter from the employer who employed them stating
2014 annual accreditation report for 2013 data ancc accredited organizations are required to submit an annual report to ancc each organization in good standing.
Background disclosure forms • attach a print out from the wisconsin nurse department chair on college letterhead indicating you left in "good standing
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subset: commoncrawl


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Stock up over 4%
Vijay Mallya owned Kingfisher Airlines took off with over 4% gains at Rs 15.05 in the opening deals ahead of its AGM today.
After the AGM meeting, lenders will meet the airlines management on Thursday to know about the carrier's plan to raise equity capital. This will be the first meeting among the banks and KFA management after the aviation sector was opened to foreign airlines last week.
Meanwhile, the Reserve Bank of India has asked banks not to treat Kingfisher Airlines' brand as collateral since it is intangible. This is because the loan has turned non-performing for most of the banks. The RBI's rejection means lenders will have to treat their exposure to Kingfisher as unsecured, for which the provisioning requirement will go up substantially.
The stock opened at Rs 14.90 and has thus far touched a high of 15.35 and a low of Rs 14.51. Around 5.6 million shares have changed hands on the BSE.
Overseas investors pumped in more than Rs 19,000 crore ($3.5 billion) in the Indian stock market in September, the highest monthly inflow in seven ...
Inquiry preliminary, based on system-generated alert
U K Sinha says 'just completing' numbers not good enough to address needs of investors
Standard gold adds Rs 30 to end at Rs 26,405 per 10 grams, silver adds Rs 200 to Rs 37,160 per kg
Many were up between 3-6%, even as an index tracking banking sector hit an all-time high
Securites and Exchange Board of India (Sebi) on Friday 'reprimanded' HSBC Securities and Capital Markets Pvt Ltd for failing to make adequate ...


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More Labrador Retriever Puppies and Dogs for sale.
We where Blessed box of chocolates ... Duckflat Retrievers in Albany, Oregon
Nice Chocolate Male ready to go Duckflat Retrievers in Albany, Oregon
Two Black Males QAA, MH x JH Duckflat Retrievers in Albany, Oregon
Black Female 9/12/14 Broke into bir... Duckflat Retrievers in Albany, Oregon
All Chocolate Litter Coming in Janu... Hill Top Acres in Harriam , Tennessee
LOOKING FOR THAT ONCE IN A LIFE TIM... Fur & Feathers Kennel in Craig, Nebraska
(WI) QAA MH Black Labrador AT STUD... Hunters Kennels in Menasha, Wisconsin
LOOKING FOR A LAB PUP FOR CHRISTMAS? WyngMaster Labradors (Est. January, 2000) in Tulsa, Oklahoma
UT,ID,MT,WA,OR,WY AKC chocolate lab pupp... Snake River Retrievers in Saint Anthony, Idaho
AKC Chocolate & White Labrador Retr... Trinity Kennels in Hubert, North Carolina
AKC Chocolate Lab pups pedigrees LO... Elite Labrador Retrievers in Central Valley, Utah
AKC Black Lab litters LOADED with F... Elite Labrador Retrievers in Central Valley, Utah
AKC STARTED CHOCOLATE & BLACK LABS!... Bird Dog Kennels AKC Started Retrievers in Battle Lake, Minnesota
Sold out chasecollin kennel in Bluff City, Tennessee
Lab Pups Ready Now Spring Creek Kennels in Newtown, Missouri
QAA Sired AKC puppies we have 2 Bla... Hill Top Acres in Harriam , Tennessee
AKC Lab Puppies for sale SES Labs in Georgiana, Alabama
Labrador Pups-Yellow and Blacks Love's Labradors in Salem, Oregon
English Lab Pups Rockford, IL Ready... Winkelman's Gun Dogs in Rockford, Illinois
FC.AFC.Skybusters Rapid Fire Son at... MAKTAWAE LABRADORS Perm. Reg'd in Simcoe, Ontario
AKC Black Lab Pups, ready after Tha... Creekside Labradors in Darwin, Minnesota
UPCOMING LITTER DUE JAN. 13TH - THUNDER ... WyngMaster Labradors (Est. January, 2000) in Tulsa, Oklahoma
AKC White Males Ready Now HUNTERS PRIDE LABRADORS in Homer City, Pennsylvania
Young Started Retrievers Available Renegade, LLC in Oxford, New York
AKC Yellow Female 1 year old Hill Top Acres in Harriam , Tennessee
CKC Hunting Bloodline Lab Puppies R... Johnson's Labrador Retrievers in Mount Juliet, Tennessee
AKC Master Hunter And Junior Hunter... Johnson's Labrador Retrievers in Mount Juliet, Tennessee
(WI) Serious Hunters & Competitors ... Hunters Kennels in Menasha, Wisconsin
GRHRCH UH -OAA- MNH Sired Labrador ... Case's Fowl Retriever's in clarksville , Michigan
4yr Yellow Lab Male - Labrador Retrievers in South Dakota - Dream Season German Wirehaired Pointers
We are offering our yellow lab male for sale. Buddy is a great hunting dog and was born 04-18-09. He has a very impressive pedigree that speaks for itself!!! Buddy is out of 4X GMPR HRCH Bearpoints Rosco MH (4X GMPR HR HPK's Hawk of Bearpoint MH & APR SHR Bearpoints Shootin Shilo JH) and MPR Kooldans Comet Shadow JH (GMPR Sauk River's Featherstorm MHR & Lazy Acres Copper Day). Buddy is OB, FF, CC, and has been guiding pheasant hunters here in South Dakota for the 2013 season. He also hunts waterfowl and doves. He does a very good job working out of a dove blind. Buddy has a great nose and will retrieve to hand all day! He is EIC clear, AKC registered, intact, and micro chipped. We are asking $1,500. Please contact me if you have any questions at 605-770-9002
Ad location: South Dakota
Ad created: Dec 19, 2013
Contact Information
Contact Name: Dan Pollreisz
605-770-9002Contact breeder through email Click here to visit website
Dream Season German Wirehaired Pointers Breeder Information
My Classified Pictures


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NField Gear
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Penguins of Madagascar
The pacing is so zany, the jokes are so rapid-fire and the sight gags are so inspired that it's impossible not to get caught up…
The pacing is so zany, the jokes are so rapid-fire and the sight gags are so inspired that it's impossible not to get caught up…
The law of diminishing returns, which has afflicted so many comedy sequels over the years, strikes again in "Horrible Bosses 2," further proving that just…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
A radio review of "Life Itself" from Mark Kermode of The Guardian.
A photo essay following Londoners through Roger Ebert's Perfect London Walk.
An interview with Jürgen Fauth, longtime film critic for About.com, and author of the anthology "Raves."
A report on films that screened at the 2014 San Diego Asian Film Festival.
A report on films that screened at the 2014 San Diego Asian Film Festival.
A report on "Song of the Sea" and "Over Your Dead Body" at the 2014 AFI Fest.
An interview with Richard Zoglin, author of the definitive biography of Bob Hope.
An interview with Benedict Cumberbatch and Keira Knightley on "The Imitation Game."
Dan Callahan is the author of "Barbara Stanwyck: The Miracle Woman" and "Vanessa: The Life of Vanessa Redgrave." He has written for "New York Magazine," "Film Comment," "Sight and Sound," "Time Out New York," "The L Magazine," and many other publications. Read his answers to our Movie Love Questionnaire here.
Obituary for Marian Seldes.
An obituary for the legendary Lauren Bacall.
Writer, director, and producer Paul Mazursky dies at 84.
An obituary for actor Eli Wallach.
An excerpt from Vanessa: The Life of Vanessa Redgrave by Dan Callahan.
A tribute to Mickey Rooney, 1920–2014.
Dan Callahan has an appreciation of the career of Joan Fontaine.
Dan Callahan looks at the career of Alfre Woodard.
Twenty years ago, promising actor River Phoenix died at 23. His last, unfinished film was "reconstructed" and shown at festivals earlier this year. The making of that film was already difficult before his death.


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Mohegans Hit Stimulus Jackpot
The Mohegan Indian Tribe has a casino, its own highway and now the tribe is preparing to build a community center – with the help of federal tax dollars. The U.S...
Tribes at odds on plan for W. Valley casino
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Walk commemorates Menominee's departure from tribal lands
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A state lawmaker says failure to pass a bond package for the American Indian Cultural Center and Museum in Oklahoma City could halt work on the project. Sen...
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Gov. Deval Patrick said Fall River "needs to take a deep breath" over its proposed casino, arguing much still has to be done before any gambling plan goes forward in the state...
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Adidas adidas Team Tiro 13 S/S Jersey - Mens - White/White
Up your performance on the pitch in the adidas Team Tiro 13 Jersey. This jersey has ventilated CilmaCool fabrication to keep you cool and dry for those long, intense matches. The crew neck style has a contrast front collar insert, and the s...leeves show... Read More


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Published April 1, 2013
Eastman Chemical Company was recently recognized by a number of leading industry, business and trade publications for its outstanding financial performance. The most recent recognition is the company's ranking on the Bloomberg Businessweek Top… Read More »
Published February 28, 2013
KINGSPORT, Tenn. – Eastman Chemical Company (NYSE:EMN) was recently recognized by a number of leading industry, business and trade publications for its outstanding financial performance. The most recent recognition is the company's ranki… Read More »
Published December 10, 2012
White/white pearl dominates the global automotive color popularity ranks for the second consecutive year, according to the 2012 DuPont Automotive Color Popularity Report, released today. Black/black effect moves into second place in the global… Read More »
Published October 12, 2010
PPG introduces 66 new shades at annual Automotive Color Trend Show. Read More »
Published March 12, 2014
Santander has brought five fast growing UK businesses to Mexico as part of a Breakthrough sponsored international trade mission, led by the London Chamber of Commerce and Industry (LCCI). The aim is to tap into the opportunities for doing busi… Read More »
Published March 15, 2006
The function and art of branding is a major contributor to the success of a product or service sold by the company that markets it. According to Webster's Dictionary, a brand is defined as "a means of identification," or "an arbitrarily adopted na… Read More »
Published August 10, 2005
DuPont Performance Coatings and Korea (Kumgang) Chemical Company (KCC), Ltd. have inked a technical cooperation agreement relating to DuPont's automotive OEM coatings technology and application know-how. The two firms have had a working relat… Read More »


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Are you Inne H M Borel Rinkes?Claim your profile
Publications (268)768.72 Total impact
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ABSTRACT: AimMost colorectal cancer patients are elderly, but there are few data on the optimal surgical treatment for this age group and most studies are observational. We have reviewed the characteristics of randomised trials reporting laparoscopic surgery for colorectal cancer to determine the degree to which the elderly are represented.MethodA search was conducted of the NIH clinical trial registry and the ISRCTN register for randomized trials on laparoscopic surgery for colorectal cancer. Trial characteristics and end points were extracted from the registry website and supplemented by published results where available.ResultsOf 52 trial protocols the majority did not state any restrictions regarding cardiac (40 [77%]) or pulmonary function (41 [79%]). More than half (30 [58%]) had no restrictions regarding ASA-score. Twenty three (44%) trials excluded the elderly either simply on age or by comorbidity or organ function. When an upper age limit was set, half of the studies had no restriction regarding organ function, indicating that chronologic age rather than physical condition was taken as the reason for exclusion. In 45 (86%) of the trials the average age of participants was less than 70years, and no details of concurrent disease were given.Conclusion Participation of the elderly in trials of laparoscopic surgery for colorectal cancer is very limited. This should be remedied in future trials if adequate information on the majority of patients with colorectal cancer is to be obtained.This article is protected by copyright. All rights reserved.Colorectal Disease 10/2014; · 2.08 Impact Factor
Article: GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer[Show abstract] [Hide abstract]
ABSTRACT: Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived 'colonosphere' cultures. GPx2 silencing caused accumulation of radical oxygen species, sensitization to H2O2-induced apoptosis and strongly reduced clone- and metastasis-forming capacity. Neutralization of radical oxygen species restored clonogenic capacity. Surprisingly, GPx2-suppressed cells also lacked differentiation potential and formed slow-growing undifferentiated tumors. GPx2 overexpression stimulated multi-lineage differentiation, proliferation and tumor growth without reducing tumor-initiating capacity. Finally, GPx2 expression was inversely correlated with H2O2-stress signatures in human colon tumor cohorts, but positively with differentiation and proliferation. Moreover, high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer. We conclude that H2O2 neutralization by GPx2 is essential for maintaining clonogenic and metastatic capacity but also for the generation of differentiated proliferating tumor mass. The results reveal an unexpected redox-controlled link between tumor mass formation and metastatic capacity.Cancer Res. 09/2014;
Article: Perforation in Appendiceal Well-Differentiated Carcinoid and Goblet Cell Tumors: Impact on Prognosis? A Systematic Review.[Show abstract] [Hide abstract]
ABSTRACT: Carcinoid tumors are the most common malignant lesions arising from Appendix and are mostly found incidentally during surgery for appendicitis. Perforation of Appendix occurs in 10-20 % of cases with appendicitis. Currently, no guidelines exist for the treatment of perforated carcinoids of Appendix.Annals of Surgical Oncology 09/2014; · 4.12 Impact Factor
Article: Preoperative characteristics of patients with presumed pancreatic cancer but ultimately benign disease: A multicenter series of 344 pancreatoduodenectomies[Show abstract] [Hide abstract]
ABSTRACT: Preoperative differentiation between malignant and benign pancreatic tumors can be difficult. Consequently, a proportion of patients undergoing pancreatoduodenectomy for suspected malignancy will ultimately have benign disease. The aim of this study was to compare preoperative clinical and diagnostic characteristics of patients with unexpected benign disease after pancreatoduodenectomy with those of patients with confirmed (pre)malignant disease.Pancreatology 05/2014; 13(3):S11. · 2.04 Impact Factor
Article: Reduced local immune response with continuous positive airway pressure during one-lung ventilation for oesophagectomy.[Show abstract] [Hide abstract]
ABSTRACT: /st>Transthoracic oesophagectomy requires prolonged one-lung ventilation causing systemic and local inflammatory responses. Application of continuous positive airway pressure (CPAP) to the collapsed lung potentially reduces pulmonary damage, hypoxia, and consequent inflammation. This randomized controlled trial studied the influence of CPAP applied to the collapsed right lung during thoracoscopic oesophagectomy on local and systemic inflammatory response. /st>Broncho-alveolar lavage fluid (BALF) from the right collapsed and left ventilated lung and serum samples were obtained during surgery from 30 patients undergoing thoracolaparoscopic oesophagectomy for cancer who were randomized for one-lung ventilation with or without CPAP applied to the collapsed right lung. Concentrations of cytokines and chemokines, in BALF and serum, were determined with Luminex. /st>Patients from the control (no CPAP) group had significantly increased concentrations of interleukin (IL)-1α, IL-1β, IL-10, tumour necrosis factor-alpha, macrophage inflammatory protein (MIP)-1α, pulmonary and activation-regulated chemokine (PARC), and IL-8 in the collapsed (right) lung when compared with patients from the CPAP group (P<0.05). The ventilated (left) lung of the control group showed increased concentrations of monocyte chemoattractant protein (MCP)-1 and MIP-1α (P<0.05). Serum concentrations of cytokines and chemokines increased during surgery, but did not differ between the control and CPAP groups. /st>A significantly lower local immune response was observed during one-lung ventilation when CPAP was applied to the collapsed lung. The findings suggest a beneficial effect of CPAP on the collapsed lung during oesophagectomy with one-lung ventilation.BJA British Journal of Anaesthesia 02/2014; · 4.24 Impact Factor
Article: Multipolar radiofrequency ablation for colorectal liver metastases close to major hepatic vessels.[Show abstract] [Hide abstract]
ABSTRACT: Resection of colorectal liver metastases (CRLM) is often hindered by their location close to the major hepatic vessels. So far, radiofrequency ablation for perivascular tumours was thought to be ineffective and unsafe due to either the heat sink effect or vascular thrombosis. The aim of this study was to examine whether RFA using multipolar probes could be a safe and effective option for CRLM adjacent to major hepatic vessels. Patients were treated with multipolar RFA during an open procedure using 3 simultaneously placed electrodes. In 52 consecutive patients with CRLM, 144 tumours were ablated with RFA. In 16 out of 52 (31%) patients, metastases were abutting major hepatic vessels. We examined whether perivascular location was a risk factor for local tumour progression. The relation between perivascular location and time to local tumour progression and recurrence free survival was assessed using cox-regression analysis. All patients were followed for at least 3 years after RFA unless they deceased before this time. Local tumour progression following RFA occurred in 17 out of 144 tumours (12%), of which 4 out of 21 were perivascular tumours. Tumour size was the only risk factor for local tumour progression in this study. Proximity to large vessels was neither a risk factor for local local tumour progression, nor for time to local tumour progression or recurrence free survival. This study indicates that patients with CRLM abutting any of the large hepatic vessels can be safe and effectively treated with RFA when using a multipolar system.The surgeon: journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 01/2014; · 1.97 Impact Factor
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ABSTRACT: To assess the impact of first recurrence location on survival following surgery of colorectal liver metastases. A total of 265 consecutive patients with colorectal liver metastases undergoing liver surgery (2000-2011) were categorized according to first site of tumor recurrence. Time to recurrence (TTR) and overall survival (OS) were determined. Uni- and multivariate analysis were performed to identify factors associated with TTR and OS. Median TTR was 1.16 years following liver resection, and 0.56 years following radiofrequency ablation (RFA). Intrahepatic recurrence following liver resection resulted in a significantly shorter median TTR compared to extrahepatic recurrence. Intrapulmonary recurrence was associated with superior survival compared to other recurrence locations. Such patterns were not observed in the RFA-treated group. Multivariate analysis identified the type of surgical treatment and extra-hepatic first-site recurrence (other than lung) as independent predictors for OS. Pre-operative chemotherapy and simultaneous intrahepatic and extrahepatic recurrence were independent predictors for both TTR and OS. Patients with intrahepatic recurrence following liver resection have a significantly shorter TTR and OS when compared to patients developing extrahepatic recurrence. Pulmonary recurrence following resection is associated with longer survival. Simultaneous intra- and extrahepatic recurrence is an independent prognostic factor for TTR and OS.Journal of Gastrointestinal Surgery 01/2014; · 2.36 Impact Factor
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ABSTRACT: Treatment of oncologic disease has improved significantly in the last decades and in the future a vast majority of cancer types will continue to increase worldwide. As a result, many patients are confronted with primary liver cancers or metastatic liver disease. Surgery in liver malignancies has steeply improved and curative resections are applicable in wider settings, leading to a prolonged survival. Simultaneously, radiofrequency ablation (RFA) and liver transplantation (LTx) have been applied more commonly in oncologic settings with improving results. To minimize adverse events in treatments of liver malignancies, locoregional minimal invasive treatments have made their appearance in this field, in which radioembolization (RE) has shown promising results in recent years with few adverse events and high response rates. We discuss several other applications of RE for oncologic patients, other than its use in the palliative setting, whether or not combined with other treatments. This review is focused on the role of RE in acquiring patient eligibility for radical treatments, like surgery, RFA, and LTx. Inducing significant tumor reduction can downstage patients for resection or, through attaining stable disease, patients can stay on the LTx waiting list. Hereby, RE could make a difference between curative of palliative intent in oncologic patient management. Prior to surgery, the future remnant liver volume might be inadequate in some patients. In these patients, forming an adequate liver reserve through RE leads to prolonged survival without risking post-operative liver failure and minimizing tumor progression while inducing hypertrophy. In order to optimize results, developments in procedures surrounding RE are equally important. Predicting the remaining liver function after radical treatment and finding the right balance between maximum tumor irradiation and minimizing the chance of inducing radiation-related complications are still challenges.Frontiers in oncology. 01/2014; 4:199.
Article: Multipolar radiofrequency ablation for colorectal liver metastases close to major hepatic vessels[Show abstract] [Hide abstract]
ABSTRACT: Background Resection of colorectal liver metastases (CRLM) is often hindered by their location close to the major hepatic vessels. So far, radiofrequency ablation for perivascular tumours was thought to be ineffective and unsafe due to either the heat sink effect or vascular thrombosis. The aim of this study was to examine whether RFA using multipolar probes could be a safe and effective option for CRLM adjacent to major hepatic vessels. Methods Patients were treated with multipolar RFA during an open procedure using 3 simultaneously placed electrodes. In 52 consecutive patients with CRLM, 144 tumours were ablated with RFA. In 16 out of 52 (31%) patients, metastases were abutting major hepatic vessels. We examined whether perivascular location was a risk factor for local tumour progression. The relation between perivascular location and time to local tumour progression and recurrence free survival was assessed using cox-regression analysis. Results All patients were followed for at least 3 years after RFA unless they deceased before this time. Local tumour progression following RFA occurred in 17 out of 144 tumours (12%), of which 4 out of 21 were perivascular tumours. Tumour size was the only risk factor for local tumour progression in this study. Proximity to large vessels was neither a risk factor for local local tumour progression, nor for time to local tumour progression or recurrence free survival. Discussion This study indicates that patients with CRLM abutting any of the large hepatic vessels can be safe and effectively treated with RFA when using a multipolar system.The Surgeon. 01/2014;
Article: Preoperative BRAF(V600E) mutation screening is unlikely to alter initial surgical treatment of patients with indeterminate thyroid nodules: A prospective case series of 960 patients.Cancer 12/2013; · 5.20 Impact Factor
Article: Early oral feeding after pancreatoduodenectomy enhances recovery without increasing morbidity.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to evaluate whether a change in the routine feeding strategy applied after pancreatoduodenectomy (PD) from nasojejunal tube (NJT) feeding to early oral feeding improved clinical outcomes. An observational cohort study was performed in 102 consecutive patients undergoing PD. In period 1 (n = 51, historical controls), the routine postoperative feeding strategy was NJT feeding. This was changed to a protocol of early oral feeding with on-demand NJT feeding in period 2 (n = 51, consecutive prospective cohort). The primary outcome was time to resumption of adequate oral intake. The baseline characteristics of study subjects in both periods were comparable. In period 1, 98% (n = 50) of patients received NJT feeding, whereas in period 2, 53% (n = 27) of patients did so [for delayed gastric empting (DGE) (n = 20) or preoperative malnutrition (n = 7)]. The time to resumption of adequate oral intake significantly decreased from 12 days in period 1 to 9 days in period 2 (P = 0.015), and the length of hospital stay shortened from 18 days in period 1 to 13 days in period 2 (P = 0.015). Overall, there were no differences in the incidences of complications of Clavien-Dindo Grade III or higher, DGE, pancreatic fistula, postoperative haemorrhage and mortality between the two periods. The introduction of an early oral feeding strategy after PD reduced the time to resumption of adequate oral intake and length of hospital stay without negatively impacting postoperative morbidity.HPB 12/2013; · 1.94 Impact Factor
Article: Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells.[Show abstract] [Hide abstract]
ABSTRACT: To assess the contribution of hypoxia and bone marrow-derived cells to aggressive outgrowth of micrometastases after liver surgery. Liver surgery generates a microenvironment that fosters aggressive tumor recurrence. These areas are characterized by chronic hypoxia and influx of bone marrow-derived cells. The contribution of hematopoietic cell types was studied in mice lacking specific components of the immune system and in irradiated mice lacking all bone marrow-derived cells. Tumor cells were derived from colorectal cancer patients and from a metastatic tumor cell line. Hypoxia-induced changes in stem cell and differentiation marker expression, clone-forming potential, and metastatic capacity were assessed. The effect of vascular clamping on cancer stem cell (CSC) characteristics was performed in mice bearing patient-derived liver metastases. Immune cells and bone marrow-derived cells were not required for aggressive outgrowth of micrometastases in livers treated with surgery. Rather, hypoxia was sufficient to promote invasion and accelerate metastatic outgrowth. This was associated with a rapid loss of differentiation markers and increased expression of CSC markers and clone-forming capacity. Likewise, metastases residing in ischemia-reperfusion-injured liver lobes acquired CSC characteristics. Despite their renowned general resistance to chemotherapy, clone-forming CSCs were readily killed by the hypoxia-activated prodrug tirapazamine. Surgery-generated hypoxia in the liver causes rapid dedifferentiation of tumor cells into immature CSCs with high clone- and metastasis-forming capacity. The results help explain the phenomenon of aggressive local tumor recurrence after liver surgery and offer a potential strategy to kill aggressive CSCs by hypoxia-activated prodrugs.Annals of surgery 11/2013; · 7.90 Impact Factor
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ABSTRACT: Rapid advances in evidence-based treatment schedules are a hallmark of modern oncology. In rare neoplastic diseases, however, clinical expertise is hard to build and evidence based on randomized trials almost impossible to collect. Gorham disease is a rare form of lymphatic proliferation accompanied by osteolysis, which usually occurs in young adults. Despite the fact that the clinical course of Gorham disease is often devastating and occasionally fatal, insights into its biological background are sparse and standardized treatment unavailable. Interestingly, recent knowledge on the mechanisms of lymphangiogenesis may help elucidate the pathophysiology of Gorham disease and lead to novel treatment targets. Here, we discuss our current understanding of Gorham disease, discuss established and emerging therapeutic strategies, and attempt to frame a treatment rationale. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.Pediatric Blood & Cancer 11/2013; · 2.35 Impact Factor
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ABSTRACT: Background:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CRC.Methods:Gene expression profiling and proteomics were used to identify differentially expressed genes/proteins in resected liver metastases that recurred within 6 months following liver surgery vs those that did not recur for >24 months. Expression of the identified genes/proteins in stage II (n=243) and III (n=176) tumours was analysed by immunohistochemistry on tissue microarrays. Correlation of protein levels with stage-specific outcome was assessed by uni- and multivariable analyses.Results:Both gene expression profiling and proteomics identified Maspin to be differentially expressed in colorectal liver metastases with early (<6 months) and prolonged (>24 months) time to recurrence. Immunohistochemical analysis of Maspin expression on tumour sections revealed that it was an independent predictor of time to recurrence (log-rank P=0.004) and CRC-specific survival (P=0.000) in stage III CRC. High Maspin expression was also correlated with mucinous differentiation. In stage II CRC patients, high Maspin expression did not correlate with survival but was correlated with a right-sided tumour location.Conclusion:High Maspin expression correlates with poor outcome in CRC after spread to the local lymph nodes. Therefore, Maspin may have a stage-specific function possibly related to tumour cell dissemination and/or metastatic outgrowth.British Journal of Cancer advance online publication, 3 September 2013; doi:10.1038/bjc.2013.489 www.bjcancer.com.British Journal of Cancer 09/2013; · 5.08 Impact Factor
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ABSTRACT: Drug-resistant Cancer Stem Cells (CSCs) have been implicated in tumor recurrence following chemotherapy. However, the contribution of CSCs to drug-resistance in colorectal cancer is unclear and CSC-intrinsic drug-resistance mechanisms are ill-defined. Here, we address these issues by proteomic analysis of the secretomes of CSCs and isogenic differentiated tumor cells (DTCs) isolated from three distinct metastasized colon tumors. Mass spectrometry-based proteomics identified 1254 unique proteins in the conditioned media of the paired CSC and DTC cultures. Ingenuity Pathway Analysis revealed that proteins governing 'Cell Death' were most significantly enriched in the CSC secretome. The vast majority of these (37/43) promote cell survival. The CSC secretome is also characterized by a pro-survival Nrf2 antioxidant signature. Interestingly, proteome-maintenance networks are highly enriched in the CSC secretome. CSCs also secrete high levels of drug-metabolizing enzymes, including aldehyde dehydrogenase 1 (ALDH1A1) and bleomycin hydrolase (BLMH). We show that these enzymes cause extracellular detoxification of maphosphamide and bleomycin respectively. We conclude that colorectal CSCs are characterized by extensive survival and anti-oxidant networks, which are likely to contribute to CSC-intrinsic drug-resistance. In addition, CSCs may modulate drug responses in nearby tumor cells by detoxifying chemotherapeutic drugs in the extracellular space. Cancer stem cells are thought to play an important role in mediating drug resistance and tumor recurrence following chemotherapy. Therefore, it is important to identify the factors that are secreted by them. Our results provide novel insights into the pathways that govern the intrinsic resistance of CSCs to chemotherapy and, furthermore, demonstrate that they can also inactivate chemotherapeutic drugs in the extracellular space. A better understanding of the pathways that govern drug resistance in CSCs may help developing effective CSC-targeting drugs.Journal of proteomics 07/2013; · 5.07 Impact Factor
Article: Radiological heterogeneity in response to chemotherapy is associated with poor survival in patients with colorectal liver metastases.[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: In patients with colorectal liver metastases (CLM) there is limited knowledge about the occurrence of radiological heterogeneity in response to chemotherapy. METHODS: A retrospective analysis was performed in the CAIRO and CAIRO II studies on the incidence of intermetastatic heterogeneity in patients with CLM and its association with survival. Mixed response (MR) was defined as >30% difference in individual lesion response, with all lesions showing a similar behaviour; true mixed response (TMR) as two lesions showing progression versus response; homogeneous response (HR) as similar behaviour of all lesions. Patients were classified according to the Response Evaluation Criteria in Solid Tumours (RECIST) categories (partial response (PR), stable disease (SD), progressive disease (PD), complete response (CR)) and then subdivided into MR and TMR in order to compare survival. RESULTS: In the CAIRO and CAIRO II studies, 140 and 150 patients with liver-only disease were identified. 73/290 (25.2%) patients showed MR, and 25/290 (8.6%) patients TMR, and 192/290 (66.2%) patients HR. Overall survival (OS) at 1-4 years was significantly higher for the homogeneous partial responders category compared to other response categories. Median OS was 22.0 months for the entire population. In the partial response category, patients with MR showed significant poorer survival compared to patients with HR (median OS 23.7 versus 36.0 months, respectively, p=0.019). Multivariate analysis identified four independent predictors for OS: serum lactate dehydrogenase (LDH) level (p=0.002), number of first-line chemotherapy cycles (p=0.001), resection of primary tumour (p=0.001) and response category (p=0.012). CONCLUSION: Radiological heterogeneity is present in approximately 35% of patients with CLM. Partial responders according to the RECIST criteria, show a significant poorer survival if classified as heterogeneous partial responder compared to homogeneous partial responders.European journal of cancer (Oxford, England: 1990) 05/2013; · 4.12 Impact Factor
Article: Patient Tailored Resection Planning in Patients Undergoing Liver Surgery for Colorectal Liver Metastases; How and Why Should You Do It?[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: A systematic preoperative evaluation to determine the individual resection strategy in patients with colorectal liver metastases (CRLM) was assessed as to its clinical value. PATIENTS AND METHODS: From 2009 to 2011, 75 patients with CRLM who were scheduled for surgery were prospectively included and received an additional preoperative systematic evaluation in the presence of a hepatobiliary radiologist and the hepatobiliary surgeon scheduled to perform the surgery. The following items were assessed in a standardized manner: lesion detection and characterization, presence of extrahepatic disease, vascular anatomy, and resection strategy. Intraoperative findings and histopathological results were prospectively recorded. RESULTS: Five out of 75 patients were not considered to be eligible for surgery due to additional findings, such as additional metastases or extrahepatic disease. Sensitivity and specificity for detection of individual CRLM were 80.9 % (95 % CI 75.7-86.1 %) and 69.1 % (95% CI 59.1-79.1 %), respectively. Radical resections were performed in 87.1 %. There was one futile laparotomy (1.4 %). CONCLUSION: In patients with colorectal liver metastases, standardized preoperative work-up, with subsequent planning of an individualized resection in a jointed meeting of a hepatobiliary radiologist and the surgeon who will perform the operation, leads to a high level of radical resections and a low number of futile laparotomies.Journal of Gastrointestinal Surgery 04/2013; · 2.36 Impact Factor
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ABSTRACT: High-resolution intravital microscopy through imaging windows has become an indispensable technique for the long-term visualization of dynamic processes in living animals. Easily accessible sites such as the skin, the breast and the skull can be imaged using various different imaging windows; however, long-term imaging studies on cellular processes in abdominal organs are more challenging. These processes include colonization of the liver by metastatic tumor cells and the development of an immune response in the spleen. We have recently developed an abdominal imaging window (AIW) that allows long-term imaging of the liver, the pancreas, the intestine, the kidney and the spleen. Here we describe the detailed protocol for the optimal surgical implantation of the AIW, which takes ∼1 h, and subsequent multiphoton imaging, which takes up to 1 month.Nature Protocols 02/2013; 8(3):583-94. · 7.96 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: High-resolution intravital microscopy through imaging windows has become an indispensable technique for the long-term visualization of dynamic processes in living animals. Easily accessible sites such as the skin, the breast and the skull can be imaged using various different imaging windows; however, long-term imaging studies on cellular processes in abdominal organs are more challenging. These processes include colonization of the liver by metastatic tumor cells and the development of an immune response in the spleen. We have recently developed an abdominal imaging window (AIW) that allows long-term imaging of the liver, the pancreas, the intestine, the kidney and the spleen. Here we describe the detailed protocol for the optimal surgical implantation of the AIW, which takes ∼1 h, and subsequent multiphoton imaging, which takes up to 1 month.Nature Protocol 02/2013; 8(3):583-94. · 8.36 Impact Factor
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ABSTRACT: BACKGROUND: Current European guidelines recommend routine enteral feeding after pancreato-duodenectomy (PD), whereas American guidelines do not. The aim of this study was to determine the optimal feeding route after PD. METHODS: A systematic search was performed in PubMed, Embase and the Cochrane Library. Included were studies on feeding routes after PD that reported length of hospital stay (primary outcome). RESULTS: Of 442 articles screened, 15 studies with 3474 patients were included. Data on five feeding routes were extracted: oral diet (2210 patients), enteral nutrition via either a nasojejunal tube (NJT, 165), gastrojejunostomy tube (GJT, 52) or jejunostomy tube (JT, 623), and total parenteral nutrition (TPN, 424). Mean(s.d.) length of hospital stay was shortest in the oral diet and GJT groups (15(14) and 15(11) days respectively), followed by 19(12) days in the JT, 20(15) days in the TPN and 25(11) days in the NJT group. Normal oral intake was established most quickly in the oral diet group (mean 6(5) days), followed by 8(9) days in the NJT group. The incidence of delayed gastric emptying varied from 6 per cent (3 of 52 patients) in the GJT group to 23·2 per cent (43 of 185) in the JT group, but definitions varied widely. The overall morbidity rate ranged from 43·8 per cent (81 of 185) in the JT group to 75 per cent (24 of 32) in the GJT group. The overall mortality rate ranged from 1·8 per cent (3 of 165) in the NJT group to 5·4 per cent (23 of 424) in the TPN group. CONCLUSION: There is no evidence to support routine enteral or parenteral feeding after PD. An oral diet may be considered as the preferred routine feeding strategy after PD. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.British Journal of Surgery 01/2013; · 4.84 Impact Factor
Top Journals
University Medical Center Utrecht
Utrecht, Utrecht, Netherlands
- Department of Surgery
Hubrecht InstituteUtrecht, Utrecht, Netherlands
University of Malaya
Kuala Lumpur, Kuala Lumpur, Malaysia
- Department of Surgery
National and Kapodistrian University of Athens
Athens, Attiki, Greece
- Division of Surgery V
Utrecht UniversityUtrecht, Utrecht, Netherlands
Diakonessen Hospital UtrechtUtrecht, Utrecht, Netherlands
Leiden University Medical Centre
Leyden, South Holland, Netherlands
- • Department of Molecular Cell Biology
- • Department of Surgery
Erasmus MC
Rotterdam, South Holland, Netherlands
- • Department of Oncological Surgery
- • Department of Radiology
Netherlands Cancer Institute
Amsterdam, North Holland, Netherlands
- Division of Surgical Oncology
Massachusetts General Hospital
Boston, MA, United States
- Department of Surgery
Harvard Medical School
Boston, Massachusetts, United States
- Department of Surgery
Erasmus Universiteit Rotterdam
Rotterdam, South Holland, Netherlands
- Department of Surgery
Het Oogziekenhuis RotterdamRotterdam, South Holland, Netherlands


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Jobs in Pennsylvania
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Recruiter/ Sales Mgmt Trainee- Harr
TEKsystems, Inc. - PA - Harrisburg (+2 locations)
Why us? TEKsystems ® offers great opportunities for advancement, personal and professional growth, and unlimited earning potential. IT markets are outperforming the rest of economy, and we are growing at a rapid pace. TEKsystems ® seeks professional individuals...
from: careerrookie.com - 10 days ago
Systems Administrator (Linux/Windows)
TEKsystems - Fort Washington, PA 19034
At TEKsystems, we seek to understand our consultantsrsquo skills, goals and interests, allowing us to present targeted job opportunities on a contract, contract-to-hire or direct placement basis. TEKsystems' leadership in the market stems from our sincere...
from: Dice.com - Yesterday
Network/Security Admin
TEKsystems - Wayne, PA 19080
The Information Security Analyst will report to the Sr. Security Manager and under limited supervision provide technical analysis and security engineering skills to investigate problems and recommend enhancement to the banks security infrastructure. Basic...
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Negotiate wages, terms and conditions of employment with candidates, and gain a commitment from candidates for current and future job requirements. Develop recruiting strategies designed to identify qualified candidates through various recruiting tools... Full Time...
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Lead QA Engineer w/ Automation
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Non-Technical Skills Motivated to contribute and do what it takes to get things done as well as motivate others Experience in leading a team effort with a collaborative team of diverse associates Ability to lead team member in system testing best practices...
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.Net Developer
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They will also have hands on development duties as well as being responsible for requirements gathering, analysis, design and development of Line of Business applications within different divisions of the Office. A few projects that they have going right...
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Customer Support Associate
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Deployment Tech
TEKsystems - Pittsburgh, PA 15211
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from: Beyond Network - Today
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I want to calculate how many numbers are palindrome in large interval data say
My simple code (python) snippet is:
def count_palindromes(start, end):
count = 0
for i in range(start, end + 1):
if str(i) == str(i)[::-1]:
count += 1
return count
start = 1000 #some initial number
end = 10000000000000 #some other large number
if __name__ == "__main__":
print count_palindromes(start, end)
Its a simple program which checks each number one by one. Its vary time consuming and takes a lot of computer resources.
Is there any other method/technique by which we can count Palindrome numbers? Any Algorithm to use for this?
I want to minimize time taken in producing the output.


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- Freeport murder suspect Damon Dixson taken into custody in Rockford
- Local gas station employee arrested for selling liquor to minor
- Renewable Fuel Standard delay 'a mixed blessing,' Bustos says
- Rockford delegation presents inaugural 'Rockford Award' to Norwegian Air
- Education in Illinois making slow progress, according to report
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- 'The Price is Right Live!' at Coronado March 1; tickets on sale Nov. 21
Major snowstorm potential next week
By Alex Sosnowski
Expert Senior Meteorologist for AccuWeather.com
STATE COLLEGE, Pa. — AccuWeather.com reports a wintry system that will make a cross-country tour beginning this weekend has the potential to develop into a major storm along the East Coast next week.
The storm is cruising northern Pacific waters to close out this week and will push into the Pacific Northwest this weekend with a modest dose of rain and mountain snow.
In fact, most of the life of this storm as it traverses the Northwest (March 2-3), then the northern Rockies and central Plains into early next week (March 3-4) will not be blockbusting news. Through this point, the storm will tend to bring travel disruptions typical of the winter months with a swath of light to moderate snow. (States in the path of the modest storm to this point include, but are not limited to, Washington, Oregon, Idaho, Wyoming, Montana, North Dakota, South Dakota, Nebraska, Iowa, Kansas and Missouri).
However, toward the middle of next week (March 4-5), as this storm crosses the Mississippi River, changes taking place in the upper atmosphere will favor gradual strengthening to the Atlantic coast. Moisture will begin to feed into the storm from the Gulf of Mexico, and we are likely to start to see heavier precipitation in the form of snow, rain and thunderstorms from the Ohio Valley states to parts of the South and the mid-Atlantic. (States likely to be most involved at this point include Illinois, Indiana, Ohio, Kentucky, Tennessee, Mississippi, Alabama, Georgia, Florida, South Carolina, North Carolina, Virginia and West Virginia).
Once the storm reaches the Atlantic coast Wednesday into Thursday (March 6-7), conditions at most levels in the nearby atmosphere and well away from the storm throughout North America will favor explosive development.
The track of this atmospheric bomb will determine whether portions of the mid-Atlantic have a foot or more of windswept snow, travel mayhem, power outages and the whole nine yards with a storm hugging the coast or another non-event with the storm heading out to sea. (States on the bubble for a major storm or a near-miss include Maryland, Delaware, Pennsylvania, New Jersey, New York, Connecticut, Rhode Island and Massachusetts, as well as the District of Columbia).
At this point, it is certainly not worth altering plans, but rather something to keep an eye on and perhaps come up with "Plan B" in case a major blizzard unfolds and wallops areas from Richmond, Va., and Washington, D.C., to Philadelphia and New York City Wednesday into Thursday.
As the track develops over land this weekend, we will have more information to pass along to followers on AccuWeather.com related to the timing of the precipitation and amount of snow and severity of any rain, thunderstorms and coastal flooding.
Some of the early weather-related problems with the storm in the Northwest this weekend will be drenching rain along the coast and snow dipping to pass levels. As with many storms that bring snow to the high country in the Northwest, there is a risk of avalanches.
Posted Feb. 28, 2013


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Bureau of Safety and Environmental Enforcement (BSEE) Director Jim Watson has announced that the Ocean Energy Safety Advisory Committee (OESC) will hold its sixth public meeting on Wednesday, January 9, 2013 and Thursday, January 10, 2013 in Washington, D.C.
The OESC is a public federal advisory body including some of the nation's leading scientific, engineering and technical experts. Chaired by former Sandia National Laboratory Director Dr. Tom Hunter, the group consists of members from federal agencies, the offshore oil and gas industry, academia, and nongovernmental organizations. The Committee provides critical policy advice to the Secretary of the Interior through the BSEE Director on improving all aspects of offshore energy safety.
The agenda for the Wednesday, January 9, 2013 meeting will address the OESC Subcommittees' activities to date on oil spill prevention, spill containment, spill response and safety management systems, the Arctic and the proposed ocean energy safety institute. On Thursday, January 10, 2013, the Committee will address interim recommendations presented to the OESC from its six subcommittees for consideration and action, including lessons learned and next steps forward.
The meeting will be held at the Department of the Interior's South Interior Building Auditorium located at 1951 Constitution Avenue, N.W. Washington, D.C. 20240. On Wednesday, January 9, 2013, committee members will meet from 8:00 a.m. to 5:00 p.m. and from 8:00 a.m. to 1:00 p.m on Thursday, January 10, 2013.
Approximately 100 visitors can be accommodated on a first-come-first-served basis. Members of the public will also have the opportunity to comment on OESC activities and related topics on a first-come-first-served basis during the time allotted for public comment and may submit written comments to the OESC during the meeting or by email to the Committee at email@example.com.
Secretary Salazar announced the establishment of the OESC on Jan. 19, 2011.
Newport News Shipbuilding, a division of Huntington Ingalls Industries (HII), hosted a keel-laying ceremony Saturday for the future USS Washington (SSN 787), a
MARIN was delighted to take part in a truly historic milestone in the industry when Daewoo Shipbuilding and Marine Engineering (DSME) asked MARIN to investigate
Following a year described as "intense activity," the Glycerine Fuel for Marine Sustainability project (GLEAMS) concluded that Glycerine is a viable, exceptionally clean alternative marine fuel.
A House of Representatives panel will hold a hearing on Dec. 11 to explore whether a decades-old law that prohibits the export of crude oil makes sense in an era of domestic energy abundance.
Unrealistic Fears and Overstated Risks obscure the benefits of new seismic data.
The United States stands poised on the edge of a bright energy future. After decades
In October 2014 the first phase of the pile testing campaign for the Wikinger offshore wind farm project was launched after the site's geotechnical investigation on the Baltic Sea had been completed.
Bollinger Shipyards, Inc. has delivered the William Trump, the 11th Fast Response Cutter (FRC) to the United States Coast Guard.
The announcement was made by Bollinger Chief Operating Officer,
Australia's defence minister has said he would not trust state-owned Australian Submarine Corp (ASC) "to build a canoe", fuelling expectations that most work in
Mariners do best when they avoid the edges of the sea – the shoals, rocks, and other hard spots. Coming into contact with the edges of the sea at other than a
As the holiday season and the end of another year quickly approaches, the towing industry patiently waits for the Coast Guard to finalize the long-awaited towing vessel inspection rule.
Metalcraft Marine's Firestorm high-speed, aluminum fireboat represents a new generation in vessel technology, especially when fitted with Sea-Fire H Series engineered fire suppression systems.
Addressing the Jones Act is just one aspect of an increasingly complicated boatbuilding environment. Stovepiped, poorly conceived regulations is another.
The sting of the recession is fading,


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Birmingham Cosmetic Surgery & Vein Center's team, which is captained by board-certified cosmetic surgeon Dr. Rifai, enhances anatomical aesthetics with noninvasive treatments and surgical procedures such as liposuction and facelifts. Microdermabrasion wands zip over sun-hardened skin and injectables such as Botox and Juvéderm work to firm up facial surfaces and fade fine lines. The med spa procedures address a range of concerns, from unwanted hair to achy muscles. Furthermore, consultations at the center are always complimentary.
SVS Vision Center?s founders opened their first shop in Sterling Heights, Michigan, in 1974 to help the community clear up its vision. But even these optical gurus never foresaw their humble business expanding to more than 60 locations sprawled across 8 states. Today, each shop continues the tradition of ensuring ocular health and crystalline sight, beginning with exams from seasoned optometrists. Afterward, patients head to the optical dispensary, where they try on frames by Coach, Tiffany, Nike, Versace, or Ray-Ban. The staff then fits the stylish selection with polarized and scratch-protected prescription lenses to help guests read books clearly or see a charging moose from a distance. Most of SVS Vision Center?s frames can also hold sunglass lenses as well, eliminating squinting during summer months and tropical vacations.
FitnessQuest's team of certified trainers and dedicated managers empowers clients of any age and fitness level to pursue healthier lives, starting with a fitness assessment that informs a custom-built program of exercise classes and nutritional guidance. Through these assessments, they create customized regimens that can help clients overcome medical issues, lose weight, or excel at sports-related tasks, such as throwing a baseball or ceremoniously hurling a water cooler at the coach from across the field after a victory. They helm a wide variety of basic and specialized classes that range from personal training, to fitness parties and corporate wellness programs.
The team also offers specialized health programs tailored to different demographics within their client base. They are also members of the Healthways SilverSneakers program, an innovative health, exercise and wellness program that helps older adults to live healthy, active lifestyles. Female-centric concerns, such as finding effective prenatal and postnatal workouts or overcoming difficulties with osteoarthritis, are addressed in their women-only exercise and nutrition program.


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Stuffing Videos, Stuffing Pictures, and Stuffing Articles
The true life of a stuffed animal
a video showing the true life of a stuffed animal.
Elmo & Cookie Monster Get it On
Watch these animals stuffed. Correction: Watch these stuffed animals.
Kim Jong-un Gets Photobombed by Two Stuffed Animals Doing Butt Stuff
And just like that, the internet has a new hero.
Kitteh Ambushes Stuffed Animal
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The story of a girl and her stuffed pig.
Tiddy Bear
Cleavage loving stuffed animals.
Stuffy Interview: Elle King
Singer, songwriter, musician Elle King surrounds herself with stuffed animals for an interview. Created by Rhys Stover http://twitter.com/#!/_rhysrhys ...
henson casting auditions
behind the scenes look at casting for stuffed and unstrung, a new live show for adults only, from the people at the jim henson company's henson alternative.
ASPCSA psa
A PSA for the American Society of Prevention of Cruelty to Stuffed Animals, saved the stuffed animals with Sarah Maclachlan ( a commercial parody from I've G...
Saving Private Panda
A mysterious folder is passed from sketchy character to sketchy character in the hopes of stopping an evil stuffed animal molester.
Koawally Gets Tagged
A stuffed koala, a laser pointer, a cat. It doesn't end well.
Moldy Bagels: Episode Five
Did you wake up this morning and feel a desperate need to see one of the 5 or 10 best shows that Northern Kentucky public access TV has to offer? Of fucking ...
STUFFED - 'Daniel Tosh'
Daniel Tosh had to apologize to an offended heckler? www.StuffedCom.com for more comics by talking stuffed animals!
Vacation Photo Reveals Family Stuffing Baby into a Cannon
"Nobody stuffs baby into a cannon." - Patrick Swayze, on vacation (via: http://redd.it/27413s)
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Stuffed peppers that will melt your tongue.
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Half-Assed Reenactments - Jurassic Park
Imagine a world where our favorite movies were created with no budget... Jurassic Park is an epic classic with seemingly realistic dinosaurs and effects. ...


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37% of U.S. mobile users favor m-commerce over stores
And 42% of U.S. smartphone and tablet owners say they will do more shopping on their mobile devices this holiday season than they did ...
37% of U.S. mobile users favor m-commerce over stores
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Hold the phone: 66% of time spent with e-retail is on mobile
So, clearly, it's not a passing fad. Clever use of mobile apps by retailers such as Target and Wal-Mart is driving more consumers to ...
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SecureBuy enables identity verification without leaving the retailer's site.
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Social media lit up as consumers crowed about buying items at ultra-low prices.
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The vendor adds four U.S. data centers and aids for Magento e-retail clients.
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The Producer's Business Handbook: The Roadmap for the Balanced Film ProducerPaperback
List price $40.72
You save $13.54 33% off
Free delivery worldwide
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- Publisher: Focal Press
- Format: Paperback | 272 pages
- Dimensions: 188mm x 231mm x 20mm | 590g
- Publication date: 7 December 2010
- Publication City/Country: Oxford
- Edition: 3, Revised
- Edition statement: 3rd Revised edition
- Illustrations note: 25 black & white tables
- Sales rank: 238,264
Product description
Gain a comprehensive understanding of the business of entertainment and learn to successfully engage in all related aspects of global production and exploitation with this revised and updated handbook. With The Producer's Business Handbook as a guide, you'll learn to create the relationships that the most successful producers have with the various participants in the motion picture industry-this guide provides a global view of how producers direct their relationships with domestic and foreign studios, agencies, attorneys, talent, completion guarantors, banks, and private investors. You get a thorough orientation to operating production development and single-purpose production companies. You'll also become familiar with the team roles needed to operate these companies, and learn how to attach and direct them. For those outside the US, also included is information on how to produce successful films without government funding. This edition has been updated to include comprehensive information on the internal greenlighting process, government financing, and determining actual cost-of-money. It includes new, simplified project evaluation tools, expediting funding and distribution. Together with its companion website (www.focalpress.com/cw/leejr-9780240814636/)--which contains valuable forms and spreadsheets, tutorials, and samples-this handbook presents both instruction and worksheet support to independent producers at all levels of experience.
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This is the single best work on financing independent films. The landscape of the film business is changing rapidly and this is one of the only books addressing one of the most difficult aspects- financing. There is more to financing a film than developing a business plan and this book shows the practical, in-depth information, efficiently written and presented. -Don Smith, Associate Chair & Associate Professor, Film & Video Department, Columbia College It is so sharply focused and so easy to digest, I am going to make it the official textbook for my online course in independent film marketing and sales across all platforms. -Sydney Levine, SydneysBuzz on IndieWIRE and IMDb, Online Instructor: UCLA Extension This is a timely book, detailing a proven method for success and providing relevant data for both investors and filmmakers. -Jillian Alexander, MBA, CM&AA, CHRC,Managing Director, Corporate Development & Strategy, Conduit Consulting LLC, Former VP-Corporate Development, SONY Pictures Entertainment and member SONY US Ventures team In show business, everyone is in love with the show, but it's the business of making significant money that turns on the big boys and girls inside the tent. Learn what they already know by reading this new edition. -Steve Ecclesine, Independent Producer (12 motion pictures and more than 700 television episodes)
Table of contents
Introduction; How the Motion Picture Industry Functions; U.S. Theatrical Distributions; International Territories; Ancillary Markets and Rights; Entertainment Banking; Completion Guarantors; Attorneys, Negotiations, and Entertainment Law; Talent, Agents, and Agencies; Development, Production, and Producing Company Structures; Development Financing; The Team; Production Company's Operation; The Producer's Business; Reports, Data and Producer's Principles


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Morgan Stanley tries to halt investor's Facebook arbitration
- Order Reprints
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By Suzanne Barlyn | November 7, 2012 7:42 AM EST
Morgan Stanley
Lawyers for Morgan Stanley, a lead underwriter for the IPO, filed a complaint in federal court in Manhattan on Monday seeking an order to stop the arbitration as it relates to the brokerage, because Morgan Stanley says the investor is not its customer.
The complaint, filed in U.S. District Court for the Southern District of New York, alleges the investor ordered the Facebook shares through Vanguard Financial Group Inc, and is, therefore, not a Morgan Stanley customer.
The investor, Uma Swaminathan of East Brunswick, New Jersey, did not return a call requesting comment.
Swaminathan filed a claim in the arbitration unit of Financial Industry Regulatory Authority in July, according to Morgan Stanley's complaint. Spokespeople for Vanguard, Nasdaq and Facebook did not immediately respond to requests for comment.
Reuters was not able to immediately review the arbitration claim because FINRA, the securities industry's self-regulator, does not make them publicly available.
A successful outcome for Morgan Stanley could be precedent for preventing other investors from using FINRA's arbitration unit as a path to resolve Facebook-related legal disputes with certain entities, said Steven Caruso, a New York-based securities arbitration lawyer.
Pushback from firms involved in the IPO could leave investors who seek arbitration with only costly, longer court cases as a way to resolve any disputes, Caruso said.
In addition to Morgan Stanley, Swaminathan also named Vanguard, Facebook, NASDAQ OMX Group Inc
Facebook's May 18 debut was marred by trading glitches and confusion. The IPO also became mired in controversy as shareholders, in more than a dozen lawsuits, accused Facebook and its underwriters of obscuring the company's weakened growth forecasts ahead of the stock offering.
Other lead underwriters were JP Morgan Chase & Co
Nasdaq OMX Group has also been sued in court by investors who claimed the exchange operator was negligent in handling orders for Facebook shares.
Morgan Stanley's main argument for putting a stop to the arbitration is that Swaminathan does not have a retail brokerage account with the firm and "has not engaged in any securities or business dealings with the firm," according to the complaint.
Investors who have brokerage accounts typically agree, when signing account opening documents, to resolve legal disputes in FINRA's forum. Swaminathan, however, does not have such an agreement with Morgan Stanley, according to the complaint.
(Reporting By Suzanne Barlyn; Editing by Leslie Adler)
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|By PlatformPCPS3Xbox 360Wii U3DSPS VitaAndroidiPhoneiPadOther HardwareEditor's Choiceby Author
|By LatestThe best and worst s : May Returns Persona Q: Shadow of the Labyrinth
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The FEAR: Nemesis
[Editor's note: aborto thefetus talks about one of the best villains ever for his Monthly Musing piece. -- CTZ]I love Survival Horror games. I'm one of those types of people who find an unnatural joy in being scared when it c...


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Dump truck, pickup truck collide near Florida's Turnpike
A dump truck overturned after a crash with a pickup truck in West Palm Beach on Friday morning.
The crash happened on Southern Boulevard at Pike Road, near Florida's Turnpike, shortly after 7 a.m.
CHECK TRAFFIC CONDITIONS: Beat The Traffic On WPBF.com
It's unclear what led up to the crash, but the dump truck was left resting on its passenger side, spilling its load of top soil onto a small portion of Southern Boulevard.
The white pickup truck suffered moderate damage its bed.
Traffic heading eastbound on Southern was delayed as of 8:45 a.m.
Drivers exiting the Turnpike onto Southern are not able to head east because the crash is blocking the roadway.
It's not clear if anyone was injured.
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Originally published Friday, January 6, 2006 at 12:00 AM
Movie Review
"Dear Wendy" fires blanks
If Jamie Bell can't rescue a movie, it's probably not salvageable. After his thrilling debut in "Billy Elliot" — and after making...
Special to The Seattle Times
If Jamie Bell can't rescue a movie, it's probably not salvageable. After his thrilling debut in "Billy Elliot" — and after making "Nicholas Nickleby," "Undertow" and "The Chumscrubber" all watchable to varying degrees — Bell meets his Waterloo in the empty, obnoxious "Dear Wendy."
At least the premise has promise. Bell plays Dickie, a nearly friendless pacifist, seemingly condemned to a pointless existence in a Southern mining town, who becomes fascinated with guns. Dickie, who is also the film's narrator, longingly addresses his favorite gun as "Dear Wendy." He quickly acquires a following among the town's losers, who gain confidence by waving their own guns around.
Dickie's lost boys, who call themselves the Dandies, include his maid's murderous grandson (Danso Gordon), a shy co-worker (Mark Webber) and an adolescent ladies' man (Chris Owen, the science geek from "October Sky"). Also part of the gang is a seemingly fearless girl (Alison Pill) who sold Dickie his first gun. Incredibly, the local sheriff (Bill Pullman) asks Dickie to become a parole officer because he's so obviously "a good guy."
Screenwriter Lars von Trier ("Dogville," "Breaking the Waves") fails to justify this bizarre turn of events. He also forgets to give the young actors any characters to play; once their eccentricities are established, there's no room for them to grow. The director, Thomas Vinterberg ("The Celebration"), does little but dote on their foolishness.
"The Battle Hymn of the Republic" turns up again and again on the soundtrack, softly at first but then with a volume that becomes stupefyingly sarcastic. In a lengthy, violent sequence that could have been lifted from "Three Kings" (an infinitely better movie), the cameras follow bullets as they puncture bodies and destroy vital organs.
"Dear Wendy" sometimes suggests an English-language Danish attempt to deal with American gun culture and the Columbine killings, but what it has to say could be summarized in a bumper sticker ("Pacifists shouldn't own guns").
Without demonstrating even minimal interest in how these youngsters bond and reach their point of no return, it builds to a shootout so ludicrous that it recalls the campy "Bugsy Malone" and its cast of machine-gun-toting 12-year-olds.
John Hartl: firstname.lastname@example.com
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Fully functional Zelda dungeon recreated in LittleBigPlanet 2
LittleBigPlanet 2 is every game ever? Creator curator Bluetonberry has a new level which might just win you over: It's a stunningly accurate recreation of the first dungeon from the NES Legend of Zelda. Check out a video (and an LBP.me link!) after the jump!
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Dave Franco
David John "Dave" Franco is an American television and film actor who is best known for his roles in the films 21 Jump Street, Charlie St. Cloud, Fright Night, Now You See Me and Warm Bodies, and on the ninth season of the series Scrubs. He is the younger brother of actor James Franco.... more on Wikipedia
Dave Franco is listed on...
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Dave Franco is #9 on
Who Should Have Been People's 2014 Sexiest Man Alive?
People Magazine has added Chris Hemsworth to their list of the Sexiest Men Alive, giving the Australian actor the prestigious title for 2014. Mel Gibson was the first hottie t...read more
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The Hottest Male Celebrities
List of Hollywood's hottest men and the most attractive male celebrities in the world. This list of sexy guys includes models, actors, musicians, singers, athletes, reality TV pers...read more
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Dave Franco is #75 on
Famous Men You'd Want to Have a Beer With
Famous men you'd want to get a drink with has a different component in voting to it than the list of celebrity women you'd want to have a drink with does: namely that you're not pi...read more
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Dave Franco is #98 on
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Who should play Christian Grey in the 'Fifty Shades of Grey' movie? That's up for heated debate. With the movie rights to the incredibly popular erotic novel now sold to Universal ...read more
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