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Medications have been known to be useful in the treatment
of panic disorder for more than 40 years. Most studies have focused
on their ability to stop or reduce the frequency of panic attacks,
but many have also addressed the effect of medication on anticipatory
anxiety, agoraphobic avoidance, limited symptom attacks, associated
depression, and global function. Medications from several classes
have been shown to be effective. When interpreting results from
trials of pharmacological interventions, it is important to consider
the study design and methods for measuring treatment outcome (see Section
V.A) and the funding source of the study.
Numerous clinical trials indicate that the SSRIs are effective for
the acute and long-term treatment of panic disorder, although there
is no clear evidence of differential efficacy among agents in this
class. Whereas an early meta-analysis (586) suggested
that the effect size for improvement with SSRIs in panic disorder
was significantly greater than for alprazolam or imipramine, subsequent
meta-analyses incorporating a larger number of SSRI studies demonstrated comparable
efficacy for the SSRIs and TCAs, with mixed results regarding the
question of whether dropout rates were lower in studies in which
patients received SSRIs, compared to those for TCAs (587, 588).
Data from a number of large randomized controlled trials demonstrate
the acute and long-term efficacy of fluoxetine for panic disorder
(74, 80, 83). Results from
one multicenter, double-blind, placebo-controlled study demonstrated
that doses of both 10 mg/day and 20 mg/day were
effective, although the 20 mg/day dose was more consistently
effective across a variety of measures (74).
Results for a number of large randomized
controlled trials demonstrate the efficacy of sertraline for the
acute and long-term treatment of panic disorder (76–78, 82, 85).
Results from a fixed-dose randomized controlled trial of 50 mg/day, 100
mg/day, or 200 mg/day of sertraline showed significantly
greater reduction for the SSRI, compared to placebo, on measures
of panic and anxiety, without evidence of a dose-response relationship
Paroxetine, both in its immediate-release and controlled-release
formulation, has demonstrated efficacy for the acute and long-term
(immediate-release formulation) treatment of panic disorder in several
large randomized controlled trials (69, 70, 72, 73, 79, 87).
Ballenger and associates (73) compared placebo to three
doses of paroxetine; the percentages of patients given paroxetine
at daily doses of 40 mg, 20 mg, and 10 mg and patients given placebo
who were subsequently panic free were 86%, 65%,
67%, and 50%, respectively. Only the difference
between 40 mg/day of paroxetine and placebo was statistically
Several randomized controlled trials of fluvoxamine for panic
disorder have also been published, with most (66–68, 84),
although not all (256, 589), demonstrating
efficacy of this agent for panic disorder. In one study (66),
a greater proportion of patients who had been given fluvoxamine
became panic free, compared with those who received placebo (61% vs. 36%).
Fluvoxamine has been shown to be effective in doses from 100 mg/day
to 300 mg/day (84).
Citalopram has also demonstrated acute and long-term efficacy
for panic disorder in large randomized controlled trials (71, 75, 81, 86).
In one double-blind trial in which 475 patients were randomly assigned
to receive citalopram (10–15 mg/day, 20–30
mg/day, or 40–60 mg/day), clomipramine (60–90
mg/day), or placebo, citalopram at 20–30 mg/day
or 40–60 mg/day was significantly superior to
placebo; citalopram at 20–30 mg/day was more effective
than 40–60 mg/day and comparable to clomipramine (71).
In one 10-week, double-blind, randomized controlled trial of escitalopram
and citalopram, administration of escitalopram led to a significantly
greater reduction in panic frequency, compared to placebo, and had
comparable overall efficacy to citalopram (86).
The concerns and debate regarding the relationship between antidepressants
and increased suicidality have already been reviewed (see Section II.H).
There is accruing evidence for a discontinuation syndrome caused
by the abrupt discontinuation of SSRIs (85, 258, 259). Although
most evidence comes from studies of patients who are being treated
with SSRIs for depression, Black and colleagues (67)
studied the effect of abrupt withdrawal of fluvoxamine from patients
with panic disorder after 8 months of treatment. A discontinuation
syndrome characterized by dizziness, incoordination, headache, irritability,
and nausea began within 24 hours, peaked at day 5 after withdrawal,
and was generally resolved by day 14.
There are few data on the optimum length of treatment following
response. Gergel and associates (342) selected patients
who had responded to paroxetine in an acute-phase trial and randomly
assigned them to receive placebo or 10 mg/day, 20 mg/day,
or 40 mg/day of paroxetine for a 12-week maintenance period.
After the maintenance phase, the rate of relapse was significantly
higher among the responders who had crossed over to placebo than
among those whose paroxetine treatment had been maintained (30% vs.
LeCrubier and associates (70) evaluated the efficacy
of paroxetine, clomipramine, and placebo for patients who completed
a 12-week double-blind trial and then chose to continue receiving
the randomly assigned treatment for an additional 36 weeks. Compared
with the placebo-treated patients, the patients who received paroxetine
experienced significantly greater reductions in panic symptoms,
and a larger proportion remained free of panic attacks throughout
the long-term study. There were no significant differences in efficacy
between paroxetine and clomipramine.
Rapaport and associates (85) examined the long-term
efficacy of sertraline in the treatment of panic disorder. Patients received
52 weeks of open-label sertraline treatment followed by a 28-week,
double-blind, placebo-controlled discontinuation trial. Compared
to those blindly tapered and switched to placebo, patients who continued
to receive sertraline were less likely to have an exacerbation of
panic symptoms (13% vs. 33%) or discontinue the
study because of insufficient clinical response (12% vs.
Three large, international, randomized controlled trials have
been performed that together provide support for the efficacy and
safety of venlafaxine ER for panic disorder. In a multicenter study
of 361 individuals with panic disorder without co-occurring depression,
the intent-to-treat population consisted of 160 participants who
were randomly assigned to receive a 10-week course of venlafaxine
ER flexibly dosed from 75 mg/day to 225 mg/day
(initiated at 37.5 mg/day for 4 days) and 168 participants
who were randomly assigned to receive matched placebo (88).
Although this study failed to find a statistically significant difference between
venlafaxine ER and placebo on the a priori primary endpoints (CGI
severity rating and proportion of participants free of panic attacks
at study endpoint), there was a significantly greater reduction
in panic attacks, with overall improvement as rated by the CGI improvement
rating and remission at endpoint (defined as a CGI improvement rating
of 1 or 2 and no panic attacks) for the venlafaxine ER group. In
a second multicenter randomized controlled trial, which included
664 individuals with panic disorder without co-occurring depression,
participants were randomly assigned to receive venlafaxine ER at
fixed doses of 75 mg/day or 150 mg/day, paroxetine
at 40 mg/day, or placebo for 12 weeks after a 2-week placebo
lead-in period (89). All active treatments were found
to be significantly more effective than placebo, with no significant
difference between the venlafaxine ER doses or paroxetine and somewhat
less sedation with the venlafaxine ER doses (3% and 4%)
than with paroxetine (13%). In a third multicenter randomized controlled
trial, which included 653 individuals with non-co-occurring panic
disorder, participants were randomly assigned to receive 225 mg/day
of venlafaxine ER, 75 mg/day of venlafaxine ER, 40 mg/day
of paroxetine, or placebo for 12 weeks after a single-blind placebo
lead-in (590). In this study, a significantly greater
proportion of patients receiving the active medications were panic
free and in remission (defined as a CGI severity score of 1 or 2
or zero panic attacks) at endpoint and had greater response from
weeks 2 or 3 onward as measured by the CGI improvement rating. All active
treatments were generally well tolerated.
An additional study examined the ability of venlafaxine ER
to prevent relapse in individuals whose panic disorder symptoms
had responded to a 12-week course of flexibly dosed (75–225
mg/day) venlafaxine ER (344). Of the 89 individuals
who had been randomly assigned to receive venlafaxine ER, time to
relapse was significantly longer than in the 80 individuals assigned
to receive placebo. During the 26-week follow-up period, secondary
measures of therapeutic efficacy, including quality of life and
disability, also showed a significant benefit for venlafaxine ER
treatment, relative to placebo.
There are currently no systematic data available on the use of
duloxetine in panic disorder, although its similar mechanism of
action to venlafaxine suggests it could be a potentially effective
The first controlled study documenting the efficacy of the TCA
imipramine in blocking panic attacks was conducted by Klein and
published in 1964 (90). In this study, imipramine was superior to
placebo for antipanic effect and for change in the CGI. Since then,
numerous controlled trials have shown that imipramine is effective
in reducing panic attacks (91, 92, 94–102, 104, 105, 107, 108, 111).
After treatment with imipramine, 45%–70% of
patients were found to be panic free, compared to 15%–50% of
those receiving placebo. In addition, patients with panic disorder
who were treated with imipramine had less agoraphobic avoidance
and anticipatory anxiety than those receiving placebo.
A number of placebo-controlled randomized trials have documented
the acute and long-term efficacy of clomipramine for panic disorder
(70, 72, 79, 103, 109, 110). Clomipramine
appears at least as effective as imipramine for panic disorder (93);
in the one double-blind, placebo-controlled study addressing this
issue, clomipramine (mean dose of 109 mg/day) was superior
to both imipramine (mean dose of 124 mg/day) and placebo
in panic reduction and decrease in score on the Hamilton anxiety
scale (102). Most placebo-controlled studies comparing
clomipramine to an SSRI demonstrate equivalent efficacy, although
with a less favorable side effect profile for the TCA.
The few studies that have evaluated other TCAs for panic disorder
support the efficacy of desipramine (106) and nortriptyline
(112). However, randomized trials comparing desipramine
with clomipramine (591) and maprotiline with fluvoxamine
(272) both found the more noradrenergic TCA to be less
effective than the serotonergic comparator.
Several research studies have shown that some patients with panic
disorder are sensitive to both the beneficial and adverse effects
of TCAs (91, 106). For example, Zitrin
and associates (91) found that 20% of the
patients in their study could not tolerate doses of imipramine higher
than 10 mg/day but still experienced panic blockade. Higher
doses of TCAs are associated with a higher dropout rate in research
studies. For example, Mavissakalian and Perel (108)
reported that among subjects treated with an average of 35 mg/day,
99 mg/day, and 200 mg/day of imipramine, the dropout
rates because of drug side effects were 6%, 15%,
and 36%, respectively.
Few studies have rigorously addressed the optimum dose of TCAs
for panic disorder. In most research studies, the mean final dose
is approximately 150 mg/day of imipramine and the maximum
final dose is up to 300 mg/day. Mavissakalian and Perel
(108) randomly assigned patients with panic disorder
to low-dose (mean, 35 mg/day), medium-dose (mean, 99 mg/day),
and high-dose (mean, 200 mg/day) imipramine. They found
that both the medium and high doses were superior to placebo in
reducing panic and not significantly different from each other;
the low dose was no more effective than placebo.
There is a suggestion in the literature that clomipramine
may be effective in somewhat lower doses than imipramine. Clomipramine
can generally be used effectively with doses less than 150 mg/day.
Given the results of the studies by Modigh and associates (102)
and Cassano and colleagues (93), it may be reasonable
to administer clomipramine in a dose range of 25–150 mg/day.
Most controlled trials of TCAs for the treatment of panic
disorder were for a minimum of 8 weeks, and time to patients' response
has not always been reported. There are few long-term studies of
TCA treatment for panic disorder in the literature. Cassano and
colleagues (99) continued to treat patients with imipramine
or placebo for 6 months after an acute-phase 8-week study and found
that imipramine remained superior to placebo for panic reduction.
Curtis and associates (104) also maintained patients
on a regimen of placebo or imipramine for up to 8 months after acute
8-week treatment and found that the placebo-treated patients had
more panic attacks and agoraphobic avoidance and were more likely
to drop out of treatment during the maintenance phase. The limited
available data are mixed about whether patients who remit during
treatment benefit more from over a year of subsequent treatment, compared
with 6 months of continued pharmacotherapy prior to discontinuation
(343, 592, 593). In one study
that examined the impact of longer-term treatment with imipramine on
relapse, relapse rates for a combined group of patients who were
randomly assigned to receive placebo discontinuation or open discontinuation
after 12–30 months of remission were compared with relapse
rates for patients randomly assigned to placebo discontinuation
after 6 months of remission (592). The rates of reported
relapse were nearly identical for the two groups (37%)
during the follow-up period after discontinuation, suggesting that
the achievement of remission prior to treatment discontinuation
may be a more critical determinant in preventing relapse than the
subsequent duration of maintenance therapy.
Alprazolam has been studied more extensively than any other
benzodiazepine for the treatment of panic disorder and is approved
by the FDA for the treatment of panic disorder. Eleven trials of
alprazolam IR for treatment of panic disorder have been published,
including the Cross-National Collaborative Panic Study, which involved
more than 1,000 patients randomly assigned to receive imipramine,
alprazolam, or placebo (594). Nine of the trials were
double-blind, and seven were placebo-controlled. Two meta-analyses
of studies on alprazolam treatment for panic disorder are also available
(402, 586).
In six of the seven double-blind,
placebo-controlled trials, alprazolam was found to be superior to
placebo in the treatment of panic attacks (104, 116, 118, 122, 123, 126),
although the remaining trial did not assess panic attacks as an outcome
measure (276). The percentage ranges of patients who
were panic free (generally assessed over a 1-week period) at endpoint
were 55%–75% for alprazolam (at doses
of 5–6 mg/day) and 15%–50% for
placebo. These percentages represent the intent-to-treat proportions
(i.e., the panic-free proportion of patients who were originally
assigned to receive active treatment or placebo at the start of
the trial); the differences between the completers were less striking
or nonsignificant because of higher dropout rates for the nonresponders
in the placebo groups. Alprazolam was superior to placebo in reducing
agoraphobic avoidance in five of the six studies in which it was
assessed, disability in five of five studies, anticipatory anxiety
in three of three studies, and Hamilton anxiety scale scores in
six of seven studies. In most of the studies, patients with primary
current major depression were excluded and the level of agoraphobic
avoidance was moderate.
Four of the 11 trials compared alprazolam to imipramine (104, 126, 221, 594).
Three of these trials were double-blind. Alprazolam and imipramine
were comparable in efficacy as measured by reduction of panic attacks
and phobias, Hamilton anxiety scores, disability ratings, and CGI
ratings. More dropouts occurred in the imipramine group in three
of the four studies.
These data support the efficacy of alprazolam (especially in
the 5–6 mg/day range) in treating multiple dimensions
of illness in patients with panic disorder who do not have primary
current major depression. A sustained-release form of alprazolam
is FDA-approved for once-daily dosing based on two placebo-controlled
studies (125, 129).
Fourteen studies regarding other benzodiazepines have also
been published (113–117, 119–122, 124, 127, 128, 130–132).
These studies support the short-term efficacy of other benzodiazepines
for panic disorder. The agents studied include clonazepam (effective
in the three double-blind, placebo-controlled trials and the only
other FDA-approved benzodiazepine besides alprazolam), diazepam
(effective in two of two trials, both double-blind and one placebo-controlled),
and lorazepam (equivalent to alprazolam in three of three double-blind
trials). One study showed superiority of imipramine over chlordiazepoxide.
Three controlled trials have established that the short-term
(4–6 week) addition of benzodiazepines (alprazolam and
clonazepam) to antidepressants produces a more rapid therapeutic
response (100, 222, 223).
Whereas no discontinuation problems were reported in the two studies
using the longer half-life clonazepam added to an SSRI and a 3-week taper
(222, 223), 10 of 17 patients in the alprazolam
study were unable to taper from 1.5 mg/day to discontinuation
in 2 weeks after 4–6 weeks of treatment added to imipramine (100).
The adverse effects of benzodiazepines in patients with panic disorder
appear similar to those reported when benzodiazepines are used for
other indications. They include primarily sedation, fatigue, ataxia,
slurred speech, memory impairment, and weakness. Some sedation or
drowsiness occurred in 38%–75% of alprazolam-treated
subjects and 11%–21% of those taking
placebo. In addition, an increased risk of motor vehicle accidents
in association with benzodiazepine use has been reported (288).
In geriatric patients, the risk of falls and fractures appears to
be greater in individuals taking a benzodiazepine, regardless of
the medication half-life or duration of use (283–287, 295, 458, 595, 596).
Memory problems were reported by up to 15% of patients taking
alprazolam and 8.5% of patients taking placebo in the Cross-National
Collaborative Panic Study (101). However, patients
may not recognize their own cognitive impairment, which limits spontaneous
reporting of this side effect and has prompted several controlled
studies to more systematically investigate the cognitive effects
of these agents in people with panic disorder. Two placebo-controlled
studies have examined the effects of alprazolam on short-term memory
at baseline and in the acute (8–12 week) treatment phase
in small samples of patients with panic disorder (about 20 patients
per group). In one study using alprazolam IR at a mean dose of 5.5
mg/day, some evidence of memory impairment was found (292),
whereas no evidence of memory impairment was found in another study
using alprazolam extended release at a mean dose of 4 mg/day
(293). A follow-up of the positive study found that,
3.5 years after discontinuation, there were no long-term memory
deficits, suggesting that there is no carryover effect after medication
has been discontinued (597). Two other reports, one
meta-analysis (598) and one review (296),
do not provide convincing evidence of long-term cognitive effects
of benzodiazepines in mixed groups of patients because of the spotty
nature of the findings and because many studies have serious methodologic
Major concerns about benzodiazepine tolerance and withdrawal
have been raised. However, according to the report of the APA Task
Force on Benzodiazepine Dependence, Toxicity, and Abuse, "There
are no data to suggest that long-term therapeutic use of benzodiazepines
by patients commonly leads to dose escalation or to recreational
abuse" (294). The studies of long-term alprazolam
treatment for panic disorder show that the doses patients use at
32 weeks of treatment are similar to those used at 8 weeks, indicating
that, as a group, patients with panic disorder do not escalate alprazolam
doses or display tolerance to alprazolam's therapeutic
effects, at least in the first 8 months of treatment. Furthermore,
data in the more severely ill Medicaid population with a mix of mostly
mood and anxiety disorder diagnoses show that long-term use of benzodiazepines
(at least 2 years) does not typically result in dose escalation,
with the incidence of escalation to a high dose being 1.6% (346).
Nevertheless, studies of dose escalation following longer periods
of benzodiazepine use, especially in specific cohorts of patients
with panic disorder, are lacking, making it difficult to draw definitive
conclusions about the potential for benzodiazepine tolerance in the
clinical treatment of panic disorder.
In terms of the occurrence of benzodiazepine withdrawal symptoms,
studies of alprazolam discontinuation in patients with panic disorder
demonstrated that significant numbers (ranging from 33% to
100%) are unable to complete a taper of the medication
after 6 weeks to 22 months of treatment. Another study showed that,
compared with imipramine, alprazolam causes significantly more withdrawal
symptoms, recurrent panic attacks, and inability to discontinue
the medication (351). An additional study suggested
that patients with panic disorder have more difficulty during tapering
of alprazolam than do those with generalized anxiety disorder, even when
the patients in both groups are treated with similar doses (599).
Difficulties during alprazolam tapering seem most severe during
the last half of the taper period and the first week after the medication
is discontinued. In many instances, it is difficult to determine
the extent to which symptoms are occurring because of withdrawal,
rebound, or relapse.
The one study comparing diazepam to alprazolam for panic disorder
indicated that both are no different from placebo during gradual
tapering of the first half of the dose (600). With
abrupt discontinuation of the remaining dose, however, alprazolam
caused significantly more anxiety, relapse, and rebound. This finding
is consistent with reports of the APA Task Force on Benzodiazepine
Dependence, Toxicity, and Abuse (294), which suggest
that there are more difficulties with short half-life, high-potency
compounds. However, apart from this one study, the issue of discontinuation
of benzodiazepines with short versus long half-lives or high versus
low potency has not been adequately addressed in relation to panic
disorder. In addition, studies by Schweizer, Rickels, and associates
(126, 351) of benzodiazepine-treated patients
with other psychiatric disorders show no significant effect of half-life
on the results of a gradual taper, but greater withdrawal severity
after abrupt discontinuation with compounds that have shorter half-lives
and with higher daily doses. Taken together, these studies suggest
that half-life is less of a factor, or in fact may not be important, given
a gradual taper schedule.
Other data suggest that certain personality traits may increase
the likelihood of discontinuation effects in panic disorder patients.
In one study of 123 patients with panic disorder, after accounting
for the effects of dose and duration of alprazolam use, as well
as pretreatment anxiety and panic frequency, measures of anxiety
symptom sensitivity and avoidance predicted difficulty discontinuing
alprazolam during a tapered, gradual withdrawal process (353).
Very few studies have empirically evaluated dosing of benzodiazepines
for panic disorder. Two studies compared alprazolam doses of 6 mg/day
and 2 mg/day (95, 278). One of
the studies showed a significant advantage for the higher dose in reducing
frequency of panic attacks (95). The other study showed very little
difference between the higher and lower doses; absence of panic
attacks at study end was found for 65% of patients taking
the higher dose, 50% of those taking the lower dose, but
only 15% of those taking placebo (278). However,
the rates of surreptitious benzodiazepine use for the lower-dose
(23%) and placebo (35%) patients were considerably
greater than the rate for the patients taking the higher alprazolam
dose (4%) (278), perhaps suggesting that the
patients did not find the lower dose or placebo clinically effective.
In addition, adverse side effects were more pronounced at the higher
dose than at the lower dose of alprazolam in that study.
In one multicenter dose-ranging trial, patients with panic disorder
were randomly assigned to placebo or one of five fixed doses (0.5
mg/day, 1 mg/day, 2 mg/day, 3 mg/day,
or 4 mg/day) of clonazepam (601). During 6
weeks of treatment, the minimum effective dose was 1 mg/day,
and daily doses of 1 mg/day and higher were equally effective
in reducing the number of panic attacks.
The dosing of other benzodiazepines in the treatment of panic
disorder is less well established. In controlled studies, lorazepam
has been given at doses of about 7 mg/day, usually two
or three times daily (119, 128). Diazepam
doses ranged from 5 mg/day to 40 mg/day in two
published trials (115, 116).
Very few data indicate the optimum length of maintenance therapy
for responders to benzodiazepines. Two published trials have compared
maintenance imipramine, alprazolam, and placebo treatment, and both
suggested that imipramine may be superior. In the study by Cassano
and colleagues (99), patients who received imipramine
and those who received alprazolam fared equally well in terms of
panic reduction during a 6-month maintenance phase, but the imipramine-treated
patients had less agoraphobic avoidance. There were more dropouts
in the alprazolam group during the maintenance phase than during
the 8-week acute treatment phase, whereas the number of dropouts
in the imipramine group did not differ between the two phases. Curtis
and associates (104) found that from month 4 through
the end of an 8-month maintenance phase patients taking imipramine
had virtually no panic attacks, whereas alprazolam-treated patients
continued to experience infrequent panic attacks. On all other measures,
however, the two medications performed equally well. In a third
investigation by Lepola and colleagues (602), 27 patients
who had been treated with alprazolam and 28 patients who had been
treated with imipramine in a 9-week trial were then followed for
3 years in a naturalistic study. Significantly more alprazolam users
than imipramine users were found to still be using their original medication
after 3 years (74% vs. 32%). The authors pointed out
that it is difficult to know whether this difference is attributable
to a better long-term response among the imipramine users than among
the alprazolam users, a greater degree of intolerable side effects
for the imipramine users, or greater difficulty in discontinuing
treatment among the alprazolam users because of physiologic dependence.
No studies of the nonselective MAOIs phenelzine and tranylcypromine
have been performed since the diagnosis of panic disorder was introduced
in DSM-III. The most modern and rigorous study (603)
involved the use of phenelzine for the treatment of "phobic
neurosis" (604). This study included patients
with what would now be called panic disorder and found phenelzine
to be effective (297).
Four studies have examined the effectiveness of moclobemide,
a reversible inhibitor of monoamine oxidase A, in panic disorder,
and the results are only modestly encouraging. Although two studies
with active comparators, but no placebo, showed comparable efficacy
to both fluoxetine (298) and clomipramine (299),
respectively, the only two published placebo-controlled studies
of this medication failed to show an effect greater than placebo
(300, 301). Although the MAO-B inhibitor
selegiline is available in the United States, there are no data
to support its efficacy for the treatment of panic disorder.
There is minimal support for the use of trazodone in panic disorder.
Although a single-blind study of 11 patients with panic disorder
treated with trazodone found significant improvement in panic symptoms
compared to a baseline period of placebo treatment (307),
a double-blind study in which 74 patients with panic disorder were
assigned to trazodone, imipramine, or alprazolam showed trazodone
to be less effective than either imipramine or alprazolam (221).
Further, a study of trazodone flexibly dosed from 50 mg/day
to 300 mg/day (mean, 178 mg/day) alone and as
augmentation to CBT failed to show greater efficacy with trazodone
or combination therapy than with CBT alone, and patients who took trazodone
had greater rates of side effects and study discontinuation (308).
Bupropion has been found to be effective in the treatment
of depression, but there is little systematic study of its efficacy
in panic disorder, and the available data are contradictory. Two small
uncontrolled trials have been published, one positive and one negative.
In the positive trial, which included 20 patients, bupropion sustained
release flexibly dosed at 200 mg b.i.d. was effective and well tolerated
(313). In the negative trial, which included 12 patients,
bupropion immediate release at high doses of 300–700 mg/day
was associated with significant side effects, including myoclonus
and one seizure (314).
Although there are a few small, positive open-label reports examining
nefazodone in panic disorder, large randomized controlled trials
are lacking (605), and there are concerns about liver
toxicity (309–311).
Although there are a few open short-term studies supporting the
potential efficacy of mirtazapine for panic disorder (315–319)
and a very small randomized controlled trial (involving 27 patients)
of mirtazapine compared with paroxetine suggesting similar efficacy
(320), substantial side effects have been noted, and
no data from large randomized controlled trials are available.
Reboxetine, a norepinephrine reuptake inhibitor, is currently not
available for use in the United States or Canada. Reboxetine has
been studied with preliminary support for its efficacy and safety
in a small randomized controlled trial involving 42 patients in
Europe and Brazil (606) and an open-label trial for resistant
patients (607), with mixed support in single-blind comparison
with SSRIs (608, 609).
There are limited data concerning the use of anticonvulsant medications
in the treatment of panic disorder. One randomized controlled trial
of gabapentin in 103 patients with panic disorder provided partial
support for its efficacy and safety (321). The only
other randomized study, a small placebo-controlled trial, suggested
that carbamazepine was not effective for panic disorder (328).
Data from small open-label studies support the efficacy of valproic
acid (322–324) and levetiracetam
(326), and very preliminary case report data support
the efficacy of tiagabine (327) and vigabatrin (327), but
more rigorous studies of these medications are needed.
There is minimal evidence that first-generation antipsychotic medications
are effective for panic disorder. In small open-label trials, significant
reductions in symptoms were observed in patients with treatment-resistant
panic disorder treated with olanzapine (329) and adjunctive
risperidone (330). Double-blind, randomized controlled
trials are needed.
A limited number of trials of antihypertensive medications have
been conducted in panic disorder. Results with beta-adrenergic blocking
agents are mixed but suggest that propranolol offers peripheral
blockade but is ineffective and/or less effective than
benzodiazepines (115, 332, 333).
A single small, 4-week, randomized controlled trial that included
25 patients supported the potential efficacy of pindolol, dosed
2.5 mg t.i.d., as augmentation for patients with panic disorder
resistant to 8 weeks of treatment with an SSRI (334).
Data are even more limited for calcium channel blockers (335)
and clonidine (336, 337) and suggest only
mild and/or transient effects, if any, for panic disorder.
Although inositol is rarely used clinically for panic disorder, two
small studies have supported its potential efficacy in treatment
of panic disorder (216, 217).
Minimal data are available
on the use of buspirone in panic disorder, and no systematic controlled
trials support its efficacy. Two reports suggest that buspirone
monotherapy is not effective for panic disorder (338, 339),
and a randomized controlled trial examining augmentation of CBT
does not suggest additional efficacy with buspirone (340).


text:
President Obama tonight joined an aggressive effort by his re-election campaign to discredit Republican rival Mitt Romney, suggesting the former corporate buyout specialist has been dishonest about his departure from Bain Capital.
His comments, in an interview with ABC affiliate WJLA-TV, come amid swirling questions pushed by Democrats about when Romney formally relinquished responsibility for the firm's activities, which have included ties to bankruptcies and outsourcing jobs overseas.
Romney says his charge ended in February 1999; the Obama campaign contends legal documents show he retained a top role through 2002.
"As president of the United States, it's pretty clear to me that I'm responsible for folks who are working in the federal government and you know, Harry Truman said the buck stops with you," Obama told WJLA-TV's Scott Thuman.
"My understanding is the Mr. Romney attested to the SEC, multiple times, that he was the chairman, CEO and president of Bain Capital and I think most Americans figure if you are the chairman, CEO and president of a company that you are responsible for what that company does," he said.
"Ultimately Mr. Romney, I think, is going to have to answer those questions, because if he aspires to being president one of the things you learn is, you are ultimately responsible for the conduct of your operations, but again that's probably a question that he's going to have to answer and I think that's a legitimate part of the campaign."
Get more pure politics at ABC News.com/Politics and a lighter take on the news at OTUSNews.com
Romney — who insists he relinquished an active role in managing Bain in 1999 and says there is no concrete evidence that shows otherwise — called the questions by the president's campaign "ridiculous and disturbing" and "beneath the dignity of the president."
"It's Chicago style politics at its worse and the President promised something better than this last time and he ought to stop it and disavow it and rein in these people who are running out of control."

subset: commoncrawl


text:
Patricia Jean Sphuler, a lon time resident of Evans, passed away on July 18, 2014 in Spokane. She was born on Sept. 17, 1931 in Spokane, the daughter of John and Betty (King) Kroll.
Patricia attended school in Colville and graduated from Colville High School in 1949. After graduation, she began working as a secretary for the telephone company in Colville.
Leona Eliza Wimmer was born May 18,1925 to Mark and Maggie Huguenin. She grew up in the Colville area and graduated from Colville High School.
She had four brothers who all preceded her in death.
She married Don Stratton in 1943. They had three children: Dianna, Cindie and Mark. She and Don divorced in 1983 and she moved to Spokane.
She married Bill Kraft in 1990. Bill passed away in 2003. She married Bob Wimmer in 2006. They moved to Arizona for a few months, then returned to Spokane. Bob passed away in 2013.
Judy Marie Stillwell Miller passed away July 10, two days
after her 78th birthday in Everett at a Rehab center where she had spent the past six months. She was born in Richland and graduated in Colville. She managed BarneyŌĆÖs Restaurant & Lounge over the years and had lived in the area for the past
25 to 30 years.
Judy never had any children of her own, but you would never know; she worried and loved all of her relativeŌĆÖs children as if
they were her own. She loved them all.
Adygene De Paulo, a 48-year resident of the Kettle Falls/Marcus area, passed away on July 14, 2014 at the age of 89. Adygene was born on July 6, 1925 in Spur, Texas, the daughter of Walter and Teresa (Kearney) Garrett. She was raised on the family cattle ranch along with five sisters and one brother. Proud to be the daughter of a cowboy, she was often found riding her beloved horse, ŌĆ£Old Red,ŌĆØ helping with the ranch chores and cattle.
The Northwest is the cur┬Łrent epicenter for much of the nationŌĆÖs summer firefighting efforts. Northwest fire officials were tracking more than 17 large fires in Oregon and Washington as of last Satur┬Łday.
Wildfires have torched close to 950,000 acres in Washing┬Łton and Oregon.
Fourteen large fires are burning in Oregon, where more than 555,000 acres are ablaze. Washington has seven large fires with acreage involved approaching 400,000 as of this writing.
VIDEO: Worst Wildfire in Washington History
Fun on the lake
Just like the song made famous by legendary folk singer Woody Guthrie, Roll On Columbia, the summer programs at Lake Roosevelt National Recreation Area are on a roll.
The Saturday's at 11 a.m. programs at the Kettle Falls Information Center continue to offer an educational and fun way to explore a variety of fascinating topics.
On July 12, local historian Dwight Morgan donned his authentic Canadian Voyageur garb and shared tales about the rough and tumble lives of these hearty explorers who once lived at the nearby Hudson Bay trading post at Fort Colvile.
The Opie-Coxie benefit
scramble golf tournament
at Dominion Meadows
Golf Course will be held on
Saturday. The tournament
pays tribute to the late John
Ochs and Steve Cox.
This fun event, open to
golfers of all ability levels,
raises money for the nonprofit
Opie-Coxie Foundation.
All proceeds from one
of the most popular golf
tournaments on the Dominion
Meadows calendar each
season are used to support
youth in the area. Funds
are utilized to help young
people participate in sports
or educational programs
they might not otherwise
be able to afford.
The foundation motto:
One of the top one-day
events in Northeast Washington
every summer will
unfold on Saturday morning
at the Gillette Lake
Campground when the
24th Tiger Triathlon gets
Swimmers will hit the
waters of Gillette Lake (altitude
3,200 feet) promptly at
8 a.m. It wonŌĆÖt take long
for the first swimmers to
emerge from the water and
get on their bicycles for
the fast, mostly downhill
ride along scenic Highway
20 to Colville High School,
where triathletes will head
out over the rolling terrain
of the Rotary Trail.
Triathletes will get the
traditional Tiger Tri race
Fay was born on Jan. 13, 1931 in Spokane to John Frank Reilly and Barbara Cox Reilly. His first school was Glenora, south of Spokane. In the second grade, the family moved to Williams Valley west of Deer Park, where he attended Williams Valley School until consolidation. Fay then attended Clayton School for two years and graduated from Deer Park High School in 1948.


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John Westlake,
14 January 2011 14:00
In next week's MCN, technical expert Kevin Ash discusses how Kawasaki has methodically rejuvenated its range of bikes, so that it now has an impressive model in almost every category. Find a Kawasaki for sale So if you were to rate each of the major manufacturers' ranges, who would come out top? Here's a quick summary of how they stack ...
John Westlake,
30 April 2009 12:10
The all-new Honda Pan European is going to be a technical masterpiece utilising the very latest technology, including a push button operated, double-clutch transmission, variable cylinder management and the next generation of the V-Tec variable valve system. In next week's MCN a Honda insider will also reveal when the new bike will go on sale.
Save money by comparing quotes. It's quick and easy
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BEL to invest USD 100 million in electronic warfare products
State-run Bharat Electronics Ltd (BEL) will invest Rs.620 crore/USD 100 million over the next five years in developing electronic warfare products jointly with the Defence Research and Development Organisation (DRDO), a top official said Tuesday.
"We will invest $100 million from ensuing fiscal year (2014-15) over the next five years for funding joint programmes with DRDO to develop electronic warfare products required for our armed forces," BEL chairman and managing director S. K. Sharma said at a conference here.
As the country's leading electronics major, BEL manufactures and supplies a range of products, including radars, electronic warfare system, sound and vision broadcasting, missiles and sonars to the Indian army, navy and air force.
With nine manufacturing facilities across the country, the company had jointly developed a mobile integrated electronic warfare system 'Samyukta' with DRDO, Electronics Corporation of India Ltd (ECIL) and the army's signal corps for tactical battlefield use.
Covering a wide range of frequencies, the system is used for surveillance, analysis, interception, direction finding and position fixing, listing, prioritizing and jamming of all communication and radar signals.
"In view of our capability to manufacture electronic warfare systems, we have decided to associate with DRDO in developing advanced and next generation electronic warfare products from inception to avoid delays in production," Sharma said at the third International Conference on Electronic Warfare (EWCI 2014).
As a force multiplier system, an electronic system needs high level of secrecy to maintain an element of surprise against an adversary. It ensures tactical and strategic advantage for armed forces during an operation.
"We sold electronic warfare systems to the armed forces to the value of Rs.2,000 crore over the years. The market potential is about Rs.10,000 crore in view of the growing requirement for such warfare by the armed forces in the coming years," Sharma added.
Earlier, delivering a keynote address, Air Marshal M. Matheswaran of the Integrated Defence Staff told about 600 delegates from across the country and overseas that information operation and information warfare were inseparable.
"Armed forces tend to put electronic warfare on backburner and information operation in the forefront. Gathering information, building upon that information against adversary by deception or jamming gives tactical advantage," he said.
Stressing on the need to educate and train more engineers on operating electronic warfare systems, he said the academia and industry should take advantage of the policy change to involve the private sector in developing the technology and products to gather information and use it for national security.
(Posted on 18-02-2014)
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Little Twig Bubble Bath - 17.4 oz
Little Twig Bubble Bath is specially made to suit baby's sensitive skin. It contains mild ingredients like Aloe Vera and Jojoba that gently cleanses and moisturizes, leaving skin feeling fresh. It is as gentle as water on your baby's skin with no synthetic fragrances.
Why You'll Love It: This bubble bath is formulated with ingredients that are extremely mild on the sensitive skin of your baby.
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Smells great, doesn't irritate
By Christabean
from Oceano, CA
About Me Parent of Two or More Children
Best Uses
Comments about Bubble Bath: Happy Tangerine - 17.4 oz:
Very pleasantly surprised with the quality of bubbles. It smells nice, doesn't irritate my daughter's skin, doesn't leave any soapy residue, and although it's a little pricey it's a good value when you consider an ounce or so is enough for each bath. This is my third time buying it, best bubblebath I've tried.
Bottom Line Yes, I would recommend this to a friend
By Skips
from Md
About Me Normal Skin
Best Uses
Comments about Bubble Bath: Calming Lavender - 17.4 oz:
Agree with the other review, the bubbles are very adequate , unlike other organic/natural products, which I've felt like I had to pour in 1/4 cup to get satisfactory bubbles, this product gives satisfactory bubbles with only a couple squeezes. Also like previous reviewer, smell is super pleasant, not strong. Very great product.
Bottom Line Yes, I would recommend this to a friend
(3 of 3 customers found this review helpful)
Best Bubbles I've Found for Organic
By Poemama
from Burlington, VT
Comments about Bubble Bath: Happy Tangerine - 17.4 oz:
Lots of great bubbles. I've tried other organic bubble baths that didn't produce very many bubbles at all (very disappointing!) This one has great bubbles and a pleasant (not over-powering scent). This is the only bubble bath we will use going forward.
Bottom Line Yes, I would recommend this to a friend
(3 of 3 customers found this review helpful)
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The ultimate imaging platform that allows for maximum payload capacity and exceptional camera control. The Infinite JIb™ Pro, based on the SkyJib Airframe, the largest most capable multi-rotor UAV system in the world. When the team at Droidworx were looking to brand name their flagship UAV they found inspiration from our company … Infinite Jib™ Inc.
How the craft does it:
A system created through the continuing desire to reach new limits. Available in a one or two person configuration, the muscular exterior delivers the strength and reliability required to soar to heights with the precision required for professional aerial cinematography or specialized industrial applications.
What does the Infinite Jib™ Pro Flight System include?
- Flight Case: Shipped in an impressive aluminum flight case, custom built with a cut foam insert to secure it. The case accommodates the SkyJib components: radio case, spare parts, battery charger and batteries. This case means business and looks it too!
- Airframe: Droidworx SkyJib 8 Airframe, the largest and strongest UAV frame available.
- Motors: 8 Plettenberg premium motors, manufactured in Germany to our specifications.
- Propellers: Your propellers are balanced before leaving our shop.
- Camera Setup: Photohigher AV200, with 2-axis stabilization provided by the Photohigher Skyline Gyro.
- Flight Controller Options: The SkyJib flight system utilizes the DJI fight controller. We have found that our customers prefer this configuration as it allows them to master the control of the craft sooner, without previous RC experience.
- GPS Integration: Providing Position Hold, Altitude Hold, Care Free Mode, Point of Interest, and Return to Home.
- Radios: Two Futaba 8FG Transmitters upgraded to 12 Channels. All switch functions clearly labelled and flight settings programmed prior to shipping.
- LiPo Flight Battery: Four MaxAmps 9000mah capacity 4-cell Batteries are includes 2 for flight and a spare set.
- LiPo Battery Charger: Hyperion 720 Duo charger, setup and pre-configured to our battery packs.
- Video Downlink: Standard is a 5.8Ghz 600mW analog video transmitter, to attach to your camera.
- Wireless HD video via the Teradek Cube optional. Optional configuration are available to address your HD needs.
- Video Goggles: Fat Shark Dominator Goggles incorporate a 5.8Ghz receiver with a cabling out for an external screen.
- Video Receiver: Your craft also comes with a second video receiver that can be used to send your downlink to a computer screen or to a separate video screen.
- Red and White LED Lighting: Designed for maximum visibility by the pilot
- Infinite Jib 3-Step Training Program:
- Includes AeroSIM windows training software and trainer radio ship when you confirm your order.
- ELITE clients have the option to use one of our full size, yet smaller, Flight Systems for 5 days to gain flight experience with a professional system.
- Once your system is completed, up to three members of your team, will attend one day of training at our location, just outside Toronto, Ontario, Canada. An Infinite Jib Technician will review technical operations, maintenance as well as guide you through your first hands-on flight experience.
Please contact us to discuss your requirements: 905-859-8857 or email: email@example.com


text:
*Check eligibility to see cards you are eligible for
Today credit cards have found massive usage due to the convenience they offer. Unlike the old days, you do not have to carry cash all the time. Whenever you go out for shopping, all you need to do is take your credit card with you, shop whatever you want, swipe your credit card at merchant's machine and walk out with your purchase. Simple, isn't it? In addition to the simplicity, Card issuers offer many type of benefits like cash back, reward points, interest free credit and discount offers on purchases made at select stores. All this makes it attractive to use a credit card in lieu of cash for your purchases. If you are wondering, "What happens after I swipe my card at merchant's machine?", then read on to know more.
When you hand over your credit card to the cashier to pay for your purchases he takes it and swipes it in the merchant's point of sale (POS) system. This system is connected to the merchant's bank via a communication link. This POS system helps in verifying your data by using an electronic verification system. The details verified include the validity of your card and the availability of sufficient balance on your credit card to pay for the purchases.
Once your details are transmitted to the merchant's bank, they are sent to your bank which then authorizes the payment if all the details are in order. This authorization is then sent to the merchant's bank, which then blocks the amount from your credit limit so as to reimburse it to the merchant later on. The authorization generates an approval code and is transmitted to the merchant. This code has to be keyed in by the cashier, after which two copies of charge slip are generated. This charge slip is your agreement to pay your issuing bank the amount of purchase. You then sign one copy of the charge slip and take the other one with you, along with your purchase.
Just like you, there are many others who use credit cards for their purchases. They also generate their own charge slips. All these charge slips are stored in batches and submitted by the merchant to his bank, once a day at the end of the working day. But remember, the nature of the relationship of the merchant with his bank is far different from your relation with your bank. It is called a merchant account and is actually a line of credit rather than a regular account. As per this contract, the bank agrees to undertake collection of payments on behalf of the merchant from his customers' banks. These payments are credited to the merchant's bank accounts after deducting the fees for all the services involved.
When the merchant deposits these batches in his bank, they are sent by the merchant's bank for clearing and settlement through the credit card association. This association charges your purchase amount to your bank and pays the amount to the merchant's bank. The merchant's bank then reimburses this amount to the merchant.
Your bank now charges your purchase amount to your credit card account. On the specific date, your bank will generate an account statement, listing all the credit and debit transactions in your account. If the debits are higher than credits, you have to pay the difference to your bank. You will also be given a due date, which is the last date by which you have to repay your bank in full. Failure to pay off this amount in full by due date will mean you will have to pay late fees as well as interest charges to the bank. These fees and charges can be very high, so be very careful.
Credit cards are a powerful credit tool to help you tide over short term financial requirements. However they must be used judiciously, as any misuse of the credit card can lead to high charges and make you fall into a debt trap, besides dropping your credit score drastically. So the watch word is - BE DISCIPLINED TO REPAY your credit card!
As the time is changing, the credit card providers have started tailoring their cards as per one's requirements.
Amex as an American multinational financial service provider is a pioneer in providing credit cards with several attractive variants that are irresistible. Guess what? You get a card for shopping, for lifestyle, for travel, to access lounges and above all you are entitled to earn reward points and loyalty points that can easily be converted into a list of rewards, gifts and a bonanza for air miles. Amex has proved itself that it is one of its kind and purely unbeatable. We have cash cards and traveller's cheques also in line with Amex. Its credit card product line is full of advantages to pull an individual to grab it at one sight. To list down its salient features, we would start with zero lost card liability, attractive offers, variety in its class, 24 x 7 customer support, lavishing membership rewards, an extra count on your pocket with payback features, privileged loyalty points and an extra dose of travel through its air miles offer. So didn't you have a watery mouth and a screaming pocket? If 'yes', then go for it now! Apply through BankBazaar and we promise you to give the best quote and deals for Amex credit card. Try it once and we will be yours!Citibank Credit card
As a division of CitiGroup- Multinational Financial service provider, Citibank is providing its services for credit cards from late back 1812. Its services in terms of credit cards are overwhelmed with attractive features and benefits. It has maintained the race and has offered the credit cards for different purposes and situations. Starting from lifestyle card, shopping card, fuel card and travel card, it has spread its arena in prepaid cards and corporate cards also. With such a boon in credit card industry from last few years, Citibank has grown unbeatably by offering features like good reward points, easy EMI's, instant loans for your financial obligations and insurance benefits on your credit cards. To avail all such benefits, apply now for Citibank credit card through Bank Bazaar and we will assure you to be in the safer hands. Apply today!IndusInd Bank Credit card
IndusInd Bank is termed as a new generation bank with its roots laid down in India in 1994. Since then, it has engaged its services in several spheres in terms of credit cards including super premium credit cards, premium credit cards, co- branded credit cards and core credit cards with attractive features in terms of golf course membership, reward points, air miles conversion and instant loans for your financial needs. What else you dream for? With an exotic range of services you get a free peace of mind at that point of time when you are in great financial trouble. So, don't wait and watch the show, just grab the venture! Apply with BankBazaar and take away the relationship that you would never want to leave and this is our promise!SBI Credit Card
SBI being one of the most trusted and demanded bank in India has come out with a long range of its credit cards. Being a pioneer in mostly all the product lines of commercial banking, SBI has stepped very aggressively in the credit cards business. Now, you will get a privilege of getting crowned with an exclusive range of credit cards and its benefits with SBI. A bunch full of varieties like premium cards, shopping and travel cards, classic cards and exclusive cards. SBI has bundled all of them with an amazing range of benefits like free movie tickets, best in class concierge services, lounge access facilities, balance transfer facility, flexi payment in EMI's, reward points, online bills payment through pay net and paytm and many more on its way. So, are you not willing to crown yourself with these mind blowing features of SBI credit cards? If 'yes', then go ahead and apply through BankBazaar to get the beat quotes ever.Axis Bank Credit cards
Gone are the days when you will simply look into your empty pockets and was forced to say 'no' to your loved one's demands. Axis bank has come up with a key to your happiness and a lock to your miserliness. Yes, Axis bank offers you with a wide range on its credit cards starting from its infinite range, signature range with flexi payment and travel benefits to its co-branded cards and my cards- exclusively designed for you. And not only this, Axis bank credit cards gives you ample of benefits like dining offers, airport lounge access offers, cash back offers, bills payment facility online, EMI conversion facility and lots more. Want to have one? Then apply through BankBazaar with the facility of comparison, application, personal assistance and a long term relationship. Apply today!HDFC Bank Credit cards
HDFC Bank being one of the top most bank in private sector has already rolled its sleeves to compete aggressively in credit card market. Every now and then, you will get acquainted with some special schemes and offers on HDFC bank credit cards. With its all-time high range of products including featured cards, co-branded cards, super premium cards, professional cards, premium women, premium travel, premium card, regular card, commercial card and cash back card, it is successfully ruling the market and its customer's pockets. Undoubtedly, the benefits and rewards attached to these cards are also pocket friendly like movie tickets, travel vouchers, Golf membership, air miles conversion, reward points, exclusive range of gifts, Bills payment, EMI facility, cash on call, instant loans, dining offers and many more. So, use the HDFC Bank credit card and fill your pocket with exclusive benefits. Want to try it? Apply with BankBazaar and be the proud owner of HDFC bank credit card!
Satish Kumar, an animation professional from Mumbai has multiple credit cards that he hardly uses. Chased by credit card sales agents with lucrative offers such as no annual fee Satish ended up owning more than four credit cards, but he uses only one outRead more
09th September 2014
Banks are trusted establishments where you deposit your money for safekeeping. The account holder has the right to withdraw deposited funds and use the bank's services associated with his account. During this time when the deposits are held with the bank, a customer builds...Read more
05th September 2014
If you are diligent with your money, have a habit of keeping a track of your expenses or run into emergencies that calls for the usage of a credit card, then by all means you can prudently tap the advantages this piece of plastic has to offer! Credit cards do qualify as a good alternative method of making payments. Read more
13th March 2014
There's no doubt that credit cards are very convenient to carry and transact with, especially when one is on holiday and it is unsafe to carry a lot of cash or when one is shopping for expensive products.Read more
30th May 2014
Polonius, a character in Shakespeare's play "Hamlet" advises his son, "Neither a lender nor a borrower be". With due respect to Polonius and his genius, credit has become a part and parcel of our life. While most of us cannot be lenders, we are bound to be borrowers because of the system we live with.Read more
25th March 2014
When credit cards first made their appearance, the mechanism involved was quite basic with limited benefits, fees and interest rate. With more credit card companies joining the fray, competition now is very intense.Read more
28th March 2014
The Banking Codes and Standards Board of India (BCSI) have prescribed self regulatory norms through which credit card issuers have to treat their customers. Next time you apply for a credit card do remember to have these norms in mind and extract the best service from the provider.Read more
12th July 2014
The use of plastic money and the increasing popularity of such formats have revolutionized the way payments are made and received. The most popular types of plastic money are debit cards and credit cards. Credit cum debit card is a single card which hasRead more
19th September 2014
Credit Card is gradually becoming a necessity. With many valuable features, this 86×54 mm card is nevertheless a magic box. Instead of carrying cash in your wallet, a credit card is easier to manage and convenient to handle. With the changing times, many peopleRead more
18th September 2014


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I'm counting down the days to payday so I can head to Anthropologie and pick up some much needed clothes. AllView full post »
Fresh air. Warm breezes. Longer days. Pitchers of sangria filled with fruit. Laughter echoing through the streets. CanView full post »
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How can I resist J. Crew's gorgeous winter dresses? With the holiday season upon us, don't we all need newView full post »
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To say I am lusting over these coats would be an understatement. I'm actually rationalizing selling my car andView full post »
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Ok, here is my part one of my final round of NYC fashion week. It finally ended last night, and the critics will weighView full post »
Catherine Malandrino is the epitome of Parisian chic. If I could have one woman give me a one-on-on styling appointmentView full post »
I might be biased because the girls from Rodarte are from California, but this brand could easily become one of myView full post »
I got to hand it to the men of fashion week: they sure know how to impress. Proenza Schouler and Marc jacobs are bigView full post »
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Check out all the other awesome goodies here. Don't say I didn't warn you about the damn exchange rateView full post »
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We're in the home stretch.
We've entered the final chapter.
We're in our Senior Year. (That is our recent terminology for an assignment here because most people are here for no more than 4 years. The newbies are Freshman; those who've been here more than a year are Sophomores; those of us on the way out are Seniors, with all of the accompanying attitude that goes with it.)
However we say it, our time in Germany will soon come to an end. I suppose soon is a relative term – we've probably got about 5 months left, give or take. (At this point we do not know when or where we are moving – that is life in the Air Force – but hopefully we'll have a destination and a plan by the end of next month.) We certainly have enjoyed our time here (with the possible exception of the first month) and if we were told we could stay another year or three I would be completely okay with that.
But with a trip back across the pond on the horizon, I find myself behaving just a little differently. Anyone who has moved frequently might recognize some of these behaviors…
- I am relentlessly purging. We've got a weight limit of 14,500 pounds and I *think* we'll be under that – we moved here with 8,000 pounds (hence the name of this blog.) But I don't want to take any chances, especially since we've accumulated a few things while we've lived here, and we have to account for the treasures we've got in non-temporary storage back in the States (which will likely prove to be frightening in the sense of what-on-earth-were-we-thinking-saving-this.) Plus, even though everything will be packed up and moved for us, we will be the ones who have to unpack and find a place for it in our new home. I don't want to deal with any more junk than I have to. When Jeremy asks me, "How was your day?" I sometimes respond with how many things I threw out or donated.
- I am purchasing the things I love. Cheap antiques and other interesting things won't be so easy to come by stateside. I am making lists for a few last shopping trips and things to look for at the Bis-Bis. I also have a running list of the grocery items I want to import, but I'll wait to buy those until just before we leave.
- I laugh at the fact that those two behaviors are diametrically opposed. I rationalize this by saying it is a process of prioritizing. I'm getting rid of the Happy Meal toys so that I can bring back more pottery.
- Been there, done that, here's my two cents. I am freely doling out advice on all things European. Need a Paris hotel recommendation? Let me tell you where we stayed the first, second, third and fourth time we went to Paris. Confused about the train system? Want to know where to shop? Need advice on what to do with the kids on a rainy day? Who is the best 1st grade teacher? Just ask. I'll gladly give my opinion (which may or may not come with the directive to check out my blog.)
- I am planning meals around the random ingredients in my cupboards. This sometimes involves purchasing three ingredients to use up that one can of whatever, but I'm slowly making progress. Really.
- I keep doing mental calculations to determine if various consumables will be used up before we move. I'd rather use it up than throw it out or move it, so I'm adjusting my usage of various items (cleaners, lotion, food items) accordingly. As a result my floors are a bit cleaner and my skin is more moisturized. Thanks for noticing.
- I have a sense of urgency about participating in annual events. Rain or shine, if we want to see it, we've got to go for it. There's not going to be a "next year." (Well, hopefully there will be a next year – I'm not predicting the end of the world or anything – but this is our last shot.)
- I keep staring at my DEROS list. That is the list that we made of all the places we wanted to travel. I've narrowed it to 5 places that I really, really, really want to visit before we leave: One more trip to London (planned!); one more trip to Paris (in the works!); a family trip to Normandy (spring break!); a trip to Denmark (maybe the stars will align?); and a trip to Stockholm (I think I'm going to have to let this one go very soon.) Sorry Munich, Canary Islands, Baltic cruise and the rest of my travel dreams. Maybe another time.
- My calendar is my friend. I stare at the pages regularly, looking for a magically free weekend to pop out at me so that I can plan one more trip to wherever. So far it is not happening.
- Visions of logistical details are running through my head. Even without a destination or departure date I find myself wondering just when we should schedule the packers and movers, when we should ship the car (and if we should sell a car), when the last day of school will be for the boys, and when we should move into a guest house. It's maddening.
- I am attempting to document the seemingly mundane aspects of life. I want to remember those little details. I want my boys to remember those little details. I'm taking plenty of photos. Smile, Döner Kabob guy! We'll always remember you!
- I have a renewed passion for the people and things I love. Perfect example: my favorite Thursday activity – meeting friends at the market – can't be taken for granted. And I ought to take lots of photos while I'm there.
- I have an LCF for the things I do not love. LCF stands for Low Care Factor, that "whatever" attitude about things that I don't want to deal with. I'm not going to get super passionate about the fact that the school bus is completely inconsistent in its arrival time. I've got trips to plan and closets to purge.


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posted Jan 17 2013 5:03PM
Rose Royce is coming to the Hampton Funk Fest! Hear my live interview with Kenny Copeland!
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- 7-케토
- 아싸이 베리 주스, 엑기스
- 에시도필러스
- 아미노산
- 항산화제품
- 아스타잔틴
- 뼈 포뮬라
- 칼슘
- 글루코사민
- 동종요법
- 히알루론산
- 크릴 오일
- 식사대용 제품, 쉐이크
- 멀티 미네랄
- 멀티비타민제
- 버섯, 약용
- 유산균, 에시도필러스
- 프로폴리스
- 피크노제놀
- 홍국
- 21st Century Health
- California Gold Nutrition
- Carlson Labs
- Country Life
- Doctor's Best
- Enzymatic Therapy
- Enzymedica
- Garden of Life
- Healthy Origins
- iHerb Brands
- Jarrow Formulas
- Life Extension
- Madre Labs
- California Extracts
- Doctor's Best
- Eclectic Institute
- Frontier Natural Products
- Himalaya Herbals
- Jarrow Formulas
- Life Extension
- Acure Organics
- Alba Botanica
- AnneMarie Borlind
- Aubrey Organics
- Avalon Organics
- Aveeno
- Derma E
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- Acure Organics
- Alba Botanica
- Andalou Naturals
- AnneMarie Borlind
- Aubrey Organics
- Avalon Organics
- Bee Naturals
Customer Reviews
Cells need Protein
2 people found the following review helpful
Posted by YourHealth on Apr 09, 2012
Purchased at iHerb
Because I have reduced my meat consumption, I rely on a pure form of protein to keep my cells healthy and regenerated. This product tastes great in a shake. I mix one scoop of this together with one scoop of Paradise Herb Protein Greens, one scoop of Chia seeds, and one Tbsp of Country Life Liquid Multi for a delicious shake, loaded with all the nutrients my body requires. I give five star ratings to all the products I review, because I have tested many different ones and only write reviews on the ones I continue to use.
Easy to Mix, Great Value and Super Berry Flavor!
1 person found the following review helpful
Posted by Bzuniga on Apr 07, 2012
Purchased at iHerb
This is one of the best protein powders I've ever tried and at half the price of some of the ultra-expensive, chemical flavored protein powders. MRM has a hit with this one while trying to keep the product as natural as possible. I'll keep ordering this protein powder for a long time to come. You should also try the Flax-N-Whey Vanilla Nut!
Tastes fantastic, mixes instantly
1 person found the following review helpful
Posted by KarlisN on May 31, 2012
Purchased at iHerb
Although at first the texture seemed quite weird due to the little fruit pieces it dissolved nicely. Tastes good with water, tastes fantastic with skim milk.
The Best.
1 person found the following review helpful
Posted by Reviewer1492824 on Dec 23, 2012
Purchased at iHerb
I have been doing bodybuilding/sports for a long, long time.I am also natural healing expert. Over the years I have used all kinds of protein supplements. MRM whey proteins are the best, also they are "clean", meaning there is no "garbage", no chemicals, no hormones. You can't put in your body garbage and expect to be well.
It taste good but I won't be buying again until the company removes Carrageenan from it.
1 person found the following review helpful
Posted by Reviewer2295193 on Sep 20, 2012
Purchased at iHerb
This seems to be very good for you and indeed it taste and mixes quite well. No that I know better, I won't buy this product again as it contains Carrageenan. I know this ingredient improves the texture of the drink but I'd rather not have something that is harmful. Carrageenan has been shown to cause colitis in lab animals and a few others including myself have had stomach problems after ingesting products with Carrageenan. Those with Colitis, autoimmune disorder or stomach problems should avoid this product and Carrageenan in general.


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80 search results for Neill Blomkamp
Elysium - Neill Blomkamp Interview
Type: Video | Date: Tuesday, Aug 6, 2013Director and Writer Neill Blomkamp talks about creating a metaphorical world, the physical scenes of Sharlto Copley and Matt Damon, and casting Jodie Foster as the villain.
Sharlto Copley says Neill Blomkamp's 'Chappie' will be 'massively unique'
Type: Post | Date: Friday, May 23, 2014How much of the 'Maleficent' star will be in his robot character?
Tell us what you thought of 'Elysium'
Type: Post | Date: Friday, Aug 9, 2013Neill Blomkamp's 'District 9' follow-up hits theaters today
'Elysium's' Neill Blomkamp preps 'Chappie' as next film
Type: Article | Date: Tuesday, Aug 13, 2013Sci-fi gangster comedy will star South African rap duo Die Antwoord
Neill Blomkamp says he's glad his 'Halo' movie didn't happen
Type: Article | Date: Sunday, Aug 4, 2013'Elysium' director calls the project's disintegration a stroke of 'luck' in his career
Sharlto Copley on the unique experience making 'Chappie'
Type: Video | Date: Tuesday, May 20, 2014HitFix sat down with Sharlto Copley recently and chatted about his upcoming film 'Chappie'.
Neill Blomkamp talks about how details matter when world-building for 'Elysium'
Type: Post | Date: Wednesday, Aug 7, 2013What is it that makes his worlds feel so real?
First plot details for Neill Blomkamp's next film, 'Chappie'
Type: Article | Date: Thursday, Aug 15, 2013Blomkamp's third film stars Sharlto Copley and South African rap dou Die Antwoord
'Elysium' director Neill Blomkamp on why he left the 'Halo' adaptation
Type: Article | Date: Tuesday, Apr 9, 2013He would still be interested 'If I was given control'
Neill Blomkamp unveils new footage from the Matt Damon science-fiction film 'Elysium'
Type: Post | Date: Monday, Apr 8, 2013The 'District 9' director discusses his new big idea and how he put it together


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The Miami Dolphins are ramping up their production of The Finsiders. Now the show will broadcast from the teams training facility from 4:00 pm Eastern to 7:00 pm Eastern.
"Our goal is to provide our fans with expanded inside access to Dolphins related content," said Claudia Lezcano, the team's Chief Marketing Officer. "The additional hour will give us the opportunity to increase our coverage of the rest of the NFL and all South Florida sports."
The show can be heard live in its entirety on the radio on 940 WINZ-AM (Miami/Fort Lauderdale) along with streaming online at Dolphins.com and from 5-6 p.m. on 1230 WBZT-AM (West Palm Beach). The show's second hour (5-6 p.m.) can be watched live in high definition on Fox Sports Florida. Visit FOXSportsFlorida.com for channel listings.
With the departure of Jesse Alger, the Dolphins were in need of a replacement host to pair with Sam Madison and O.J. McDuffie. Greg Likens will be his replacement and will start April 14th according to a press release from Director of Communications Jason Jenkins. Here is that announcement.
Greg Likens joins the Dolphins as the new host of The Finsiders starting on Monday, April 14. He will join several prominent alumni members on the show, which features in-studio interviews with Head Coach Joe Philbin and key Dolphins players. The highly interactive show breaks down the latest Dolphins, NFL and sports news. The show also features the opinions of Dolphins fans from around the world. Fans can call the show at 1-8-555-GO-FINS; text their questions and comments to 347347; participate in the show's live chat hosted by Tristin Jones, which is the place for fans and the on-air personalities to discuss the day's topics; and reach out to the host and analysts on Twitter.
Tags: Finsiders Miami Dolphins


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Kelsie Huff
facebook | twitter | website | news
Like most Chicago comedians, Kelsie studied at iO and Second City. While nailing her object work and "yes anding" her heart out she met Amy Sumpter and formed the two women sketch comedy team Children of the Absurd. Their signature show titled "10% Less Fat" focused on the absurdity of female body image and was performed all over the Midwest.
Huff then wrote and produced her acclaimed one woman show, HUFFS, which explored the struggle to find forgiveness in one dysfunctional family tree. It was given a 4 out of 4 review from Boulder's Daily Camera, was a "Don't Miss" in Time Out Chicago and Kelsie received the Camera Eye Award for Best Performance by an Actress in a Leading Role (Comedy).
Kelsie's second one woman show, BRUISER: Tales from a Traumatized Tomboyreceived 4 out of 4 stars in the Chicago Stage Review, Best Solo Performance of 2011, and was declared a "Midwestern American Intangible Cultural Treasure" by Boulder International Fringe Festival Board Member, Michael Hibner.
She is very proud to produce the monthly all female comedy showcase the kates.
Kelsie can currently be seen performing stand-up around Chicagoland and continues to work at clubs in Chicago, the suburbs, and colleges; anywhere that will pay her or at least give her donuts. http://www.kelsiehuff.com


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"Analog Circuits in Sensor Applications"
Dr. Ross Walker University of Utah Electrical & Computer Engineering Department When: Monday, October 27, 2014 at 3:05 p.m.Where: Warnock 1250 Abstract Analog and mixed-signal circuit technology is a fundamental enabler of sensor applications spanning environmental measurement, implantable biosensing, experimental laboratory measurement, distributed sensor networks, 'smart cars', and others. Modern sensor systems have roots in precision analog sensor interface
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Faculty Openings
Faculty Openings The Department of Electrical and Computer Engineering at the University of Utah seeks applications to fill multiple tenure-track positions at all levels. Exceptional candidates in all areas of ECE, including interdisciplinary areas, are invited to apply. We have particular interest in candidates working in research areas that require expertise in energy/power or computer
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Record Crowd at Engineering Day 2014
On Saturday, Oct. 11, about 500 high school students and their parents arrived at the University of Utah to learn how the College of Engineering can take their education to new heights. For Engineering Day 2014, which was sponsored by Rio Tinto, local students were invited to come talk to engineering faculty, view fascinating demonstrations
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COMS 2014 Coming to Salt Lake City
For the first time, the annual international COMS Conference will be held in Utah, bringing some of the world's top researchers, policy makers and entrepreneurs to Salt Lake City to talk about the commercialization of micro, nano and emerging technologies. The conference, which is developed by the Micro and Nanotechnology Commercialization Education Foundation (MANCEF)
Learn More
"Navigating New Directions in Engineering"
Univ. of Utah ECE Dept. Frontiers in Engineering Innovation Judd Distinguished Lecture Dr. T.E. Schlesinger Benjamin T. Rome Dean Whiting School of Engineering Johns Hopkins University When: Monday, October 20, 2014 at 3:05 p.m.Where: Sorenson Molecular Biotechnology Building (SMBB) 2650 – Auditorium Abstract The latter half of the twentieth century has been the age of the transistor.
Learn More
U Engineers Come Up with Bright Ideas for Solar Panels
Mike Scarpulla and his engineering team are studying new ways to produce solar panels quickly and make them more efficient, and their work is getting recognized. On Monday, Oct. 6, Scarpulla, an Associate Professor at the University of Utah, spoke at the bi-annual Bay Area Photovoltaic Consortium (BAPVC) meeting at the University of California, Berkeley campus
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"Big Data Visual Analysis"
Dr. Chris Johnson Director, SCI Institute Distinguished Professor, University of Utah School of Computing When: Monday, October 6, 2014 at 3:05 p.m.Where: Warnock 1250 Abstract We live in an era in which the creation of new data is growing exponentially such that every two days we create as much new data as we did from the beginning
Learn More
Engineering Day at the University of Utah
'Engineering Day' Ready to Host Local Students Read the full story here The upcoming University of Utah's annual Engineering Day is designed to leave local high school students with one important thought — there is a world of possibilities to explore here. This year's event, which is being sponsored by Rio Tinto, will be
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"The College of Engineering at the University of Utah"
Dr. Richard Brown Dean, University of Utah College of Engineering Professor, University of Utah Electrical & Computer Engineering Department When: Monday, September 29, 2014 at 3:05 p.m.Where: Warnock 1250
"High-Efficiency PA Techniques: Incorporating Novel Devices and Architectures for Improved Efficiency Wideband and High-Speed Communication"
Dr. Jeffrey S. Walling University of Utah Electrical & Computer Engineering Department When: Monday, September 22, 2014 at 3:05 p.m.Where: Warnock 1250 Abstract CMOS is used nearly ubiquitously for digital computation, and as such plays an ever increasing role in our lives as we increasingly use computation to improve working efficiency. Increasing levels of integration have made it
Learn More


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Who do you think looks best today? (5 photos)
The best street style from London Fashion Week: http://ow.ly/p48HS via @StyleCaster
Beauty Products We Love
Our holiday fragrance lineup just got more decadent thanks to #Marni's...
Halle Berry likes her jeans to look lived in. The hot mama often wears distressed denim and a bodycon t-shirt while toting daughter Nahla around town.Read MoreLess


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The Vandenberg building, originally called the Weaver School, was built in 1952 as the first structure used specifically for the education of the children of Ellsworth Air Force Base.
General Hoyt S. Vandenberg (1899-1954) was instrumental in the foundation of the Strategic Air Command under Chief of Staff Dwight D. Eisenhower.
When the Air Force became independent in 1947, Vandenberg was its first Vice Chief, and upon the retirement of General Carl M. Spaatz in 1948, he became Air Force Chief of Staff.
In 1948, the Berlin Blockade began and Vandenberg's Air Force bore the brunt of that crisis by mounting the successful Berlin Airlift.
By his retirement in 1953, he had transformed the Air Force from a shoestring Air Force into the modern power it is today. It was fitting to name the building in General Vandenberg's honor.
Built on government land and maintained by the Air Force, the original Vandenberg building consisted of eighteen classrooms. The Rapid City Independent District contracted and operated the Vandenberg School. Because the base population grew so rapidly, in 1955 an eight classroom addition was added to the original structure.
By June 15, 1955, using temporary buildings on Base and the Vandenberg Building, the present Douglas School System was in operation. On July 21, 1972, construction of a gymnasium and a library was begun as part of an agreement to deed the property over to the Douglas School System. On October 16, 1974, the Douglas School System accepted the land and building with the title being cleared in 1995. Since the summer of 1991, the Vandenberg Building has housed fourth and fifth grade students.
The 2014-15 school year will be the last year Vandenberg houses 4th and 5th grade students. Starting in the fall of 2015, the new Vandenberg School building will open. It will be located on Briggs Street across from Badger Clark School.
An ariel view of Vandenberg School in 1956.


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Rio, I <3 You!!!
Rio, I <3 You!!!
Dreams don't live
They move from cities…
Exchanging the beats
When they are tired, they wander…
Exchanging realities…
Changing steps…
They yearn
They get lost in conformance
From spaces between spaces
They touch deformities
Tuning forks…
Dreams do not live, they dream.
Poem by Joyce Damy Mobley
Music 'Ressurreição' (Resurrection) by Francisco Mário (Chico Mário)
One of the most beautiful works I have ever seen!!!
My prayers are with you and your patients Dr. Adams!!! :)
(Source: drwaynedyer.com)
Never doubt that a small group of thoughtful committed citizens can change the world. Indeed, it is the only thing that ever has.
Margaret Mead


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The Yankees are looking to build a winning streak, as they face off against the Indians at 7:05 PM for the second game of a four-game set.
Pitching sensation Masahiro Tanaka will get the start for the Yankees. Tanaka is looking for his 13th win of the year, as he continues to make a dominant impression in his rookie season. His record sits at 12-3, with an impressive 2.27 ERA. He didn't have his best stuff in his last start against the Twins on Thursday, but still was able to come out victorious. In that game, he went seven innings, giving up four runs on nine hits. After recently being selected to the All-Star Game, Tanaka hopes to take the mound tonight and continue to put up those unbelievable numbers that has been shown all season long.
Trevor Bauer will be the opposing pitcher for the Indians, as he comes into the game with a 2-4 record and 4.42 ERA. In his last start against the Tigers on Saturday, Bauer went 6 1/3 innings and gave up four earned runs. He got a no decision because of the Indians losing that game in extra innings. Bauer comes into the game with a 1.43 WHIP.
If Tanaka wins tonight, it will be his 13th victory of the season and will lead the Major Leagues.
Former Yankee Chris Dickerson seems like he will be a player to keep an eye on, as he just recently got called back up to the Indians after spending some time with Triple-A Indianapolis. Dickerson was hitting .309 with seven homers, 15 doubles and 44 runs batted in with 65 games being played. Last night, he went 1-for-2 and scored a run for the Tribe.
After last night's game, the Yankees have now won 12 of their last 14 games against the Indians, and have a 54-30 all time record at Progressive Field.


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All you have to do is drop the name of the character and the actor/actress who plays it in my askbox and I'll make the posts for you.
Please let me know if you want to be credited.
Please notice that the meme "Not sure if attracted to" is not mine, neither the photos and gifs I'll put in the posts .
It had to be done!
As requested by ninastales
As requested by bigbadhale-stilinski
Back to business
I know is been a while since I last posted, but some things happened and I was out of time. I'm really sorry.
But now I'm back and I'll post the "not sure if attracted" that I should have posted last time.
Also, I'm accepting new requests ;D
The characters/actors I'll be posting:
Sherlock/Benedict Cumberbatch
Sylar/Zachary Quinto
Crowley/Mark Sheppard
Chris Hemsworth/Thor (or the Huntsman)- Since there's a Thor already I'll make with the Huntsman this time \o
Patrick Adams/Mike Ross
Danny Williams/Scott Caan
From the last to the top, according to the dates of the requests XD
The person who requested Dante Basco would like to pick a character?


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Its like Dr. Buss is guarding the Lakersball.com. Nothings dropping
Mike Trudell @LakersReporter 8m
LAL's updated starting line up tonight: Marshall, Meeks, Johnson, Kelly and Kaman.
Laker Nation @LakerNation 12s
Lakers back down to eight available players: Marshall, Meeks, Johnson, Kelly, Kaman, Hill, Sacre and Farmar.
Uncle_Meat wrote:What a disaster. Like there's a surplus of point guards. The FO are making fools of themselves.
Users browsing this forum: Yahoo [Bot] and 1 guest


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Cream Male Poodle
• Male • $1,000
Kennel Closing
• Male • $3,000
Royal Brown
• Male • $1,500
Royal Apricot
Poodle, Standard Puppy
Receive an email alert when additional Poodle, Standard puppies are added. It's easy and free!
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INCLUDES: vet checked, crate, house trained, gentle,loving, dew claws removed
Puppies come with FREE Pet Insurance when adopted from NextDayPets.com! *Please ensure your breeder participates
Have a Heart dog homes
Member Since: April 2010
Location: Madison, Wisconsin
• Male • $300


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Jun 16
How can I spread the word about GO?
Want posters or postcards for your community? We'd love for you to help us spread the word about GO!
You can pick up posters or postcards from the Brooklyn Museum Visitor Center on the first floor of the museum.
The Visitor Center is free and open to the public during museum hours: Wednesday to Sunday from 11am to 6pm, with extended hours (til 10pm!) on Thursdays.
Click here to find directions to the museum from your location.


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an amazing person who will do anything for her friends. she can eat forever and still have a perfect figure. she is the most beautiful person alive. she is not afraid to get muddy or wet. she is a country girl born and raised in the city. your life will be enhanced the moment you lay eyes on her, she is very hipper and full of energy. you can always count on her to cheer you up.
holy crap that girl is fine who is she
she is danielle
she is danielle
by tanye b. December 02, 2013
Danielle is one of the prettiest and most caring girls you will meet. She has brown hair with natural highlights and hazel eyes that look green in bright light. She is super funny and honest and wants to have everyone's approval but will never change herself for anyone. She wants to be close to everyone and hates silence. She has the best clothes and is always smiling. She likes to think that she acts black, but in reality, she is the whitest girl you've ever met. She tries her best in things that she loves doing, but when she hates something, she really hates it. Danielle loves the beach, animals, and wishes she has time to learn everything in the world that anyone could possibly know. Nobody can say a bad word towards Danielle. Danielle is beautiful and funny and deserves only the best.
That girl is super awesome, she must be a Danielle!
by Awesomemc April 20, 2013
a word used to describe a high amount of anger.
stubs toe* : DANIELLE, THIS HURTS LIKE A BITCH. use "danielle" instead of "OW"
by yolochick123 January 01, 2013
Danielle is a really pretty blonde girl who just loves life, she keeps her family close to her and try's her best to succeed. She is really good at keeping those big secrets and always has your back. She rarely cry's, and keeps most of her secrets to her close friends. She doesn't get alot of guys, but they all do admire her, there just too afraid to ask her out. Danielle's normally have green or blue eyes, which show her huge personality, Danielle's talk a lot and will always make you laugh! She will help you with anything you need, just if you ask.
I would not have been able to make it through this with out a Danielle.
by swimmingstar456 November 22, 2012
To Danielle is to randomly pass out for no apparent reason. Even doctor's can't figure out why one Danielle's.
Rohaan : it was so weird last night, I was just walking then out of the blue, I just Danielle'd!
Jacob : WHAAAAAT? Bro, you never Danielle like?
Rohaan : I know, it was peculiar.
Jacob : WHAAAAAT? Bro, you never Danielle like?
Rohaan : I know, it was peculiar.
by The_Rohbot November 13, 2012
Danielle. She is the craziest person you will ever meet, she has a good sense of humour, and a great friend. To her, looks don't matter, and neither does popularity, she'll be the nicest person you'll meet. She's loyal, and trust-worthy. She's fiery, but that's something special about her. Her best friend, is like her too, she'll be the best friend you'll ever have, and you'll be sad to see her go.
Kid 1: Awh, that kid is so nice! I wish she was my best friend! She's completely crazy, but that's the best thing about her!
Kid 2: Yeah, her name's Danielle!
Kid 1: OH, well that makes perfect sense, ayee!
Kid 2: Yeah, her name's Danielle!
Kid 1: OH, well that makes perfect sense, ayee!
by Gryffitherin December 12, 2011
La meilleure mère au monde, elle est gentille, drôle, généreuse, on ne peut pas demander mieux ! Elle est et elle sera toujours dans le coeur de ses proches. Danielle est originale, spéciale et pure. Peu importe ce qu'il arrive elle sait comment réagir et elle est importante pour tout le monde. On peut toujours compter sur Danielle. Son sourire est contagieux, même si on ne le dit pas assez souvent, on la remercie du fond du coeur et on l'aime énormément.
Danielle :)
by Lilimusic8 May 14, 2011