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Latest Headlines
Latest Headlines
UPDATED: Orexigen's weight-loss med sets up Takeda vs. Eisai marketing showdown--eventually
Orexigen Therapeutics is on the verge of FDA approval for its obesity drug, after several long years of delay and frustration. But despite its late-to-the-party status--it's the third weight-loss pill in a new generation of treatments--it may end up winning the popularity contest.
With DTC on a roll, Eisai plots another 200-rep boost to Belviq sales team
The Japanese drugmaker Eisai, which is partnered with Arena Pharmaceuticals on the weight-loss pill Belviq, plans to add another 200 contract sales reps to its team.
Fresh off a TV ad launch, Eisai plots another 200-rep add to Belviq sales force
Japanese drugmaker Eisai, which is partnered with Arena Pharmaceuticals on the weight-loss pill Belviq, plans to add another 200 contract sales reps to its team. On top of a new television ad push begun last month, the sales-force expansion is a one-two punch aimed at keeping prescription trends on the upswing.
Eisai's revved-up Belviq marketing starting to pay off, analysts say
When it comes to addressing the market, pharma has three P's, according to Eisai's Michael O'Brien: physician, payer and patient. And as VP of specialty marketing, O'Brien is looking to hit each of them in promoting the recently launched weight-loss drug Belviq.
Vivus, Arena hope Aetna weight-management program boosts diet-drug sales
Both Vivus and Arena marketing partner Eisai have partnered with healthcare benefits provider Aetna, which will integrate rival obesity drugs Qsymia and Belviq into a weight-loss lifestyle pilot program.
Eisai bets another $60M on Arena's Belviq with worldwide marketing deal
Eisai gave Arena Pharmaceuticals' obesity drug Belviq another vote of confidence. The Japanese drugmaker, already marketing the drug in the U.S., signed up to promote it in most other global markets, too. And it gave Arena a $60 million up-front payment to seal the deal.
New Vivus chief's Qsymia marketing plans raise turnaround hopes
Vivus announced second-quarter losses much worse than anyone expected. It took the first public comments from incoming CEO Tony Zook to sustain hopes for a turnaround.
Expect a long slog for diet drugs Qsymia, Belviq
Vivus says its new diet drug Qsymia is now available in 8,000 retail pharmacies, putting it closer to patients. Arena Pharmaceuticals' Belviq is finally on the market, and scripts are coming in. But this new generation of weight-loss pills still faces an uphill climb--despite the tantalizing size of the market.
Analysis: AMA decision on obesity will boost drug R&D in a troubled field
The AMA's decision to classify obesity as a disease is a direct attempt to persuade biopharma companies to develop new therapies by making it harder for payers to decline coverage while applying pressure on the FDA to approve more drugs faster. And that could provide a serious incentive for the obesity therapies already in development while making the preclinical work in the field more attractive to Big Pharma companies--which have largely avoided the field after witnessing repeated marketing debacles for unsafe meds. Read more >>
Battle of weight-loss drugs begins as Arena launches Belviq next week
The long-awaited battle between two weight loss drugs is ready to begin. With its launch for Belviq delayed by the DEA, Arena has had to sit back and watch competitor Vivus pass it by with its own weight-loss drug. Now, nearly a year after the FDA cleared Belviq for approval, investors will get the chance to see if it can outperform its underwhelming competitor, Qsymia.


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Please Note: The weather is warm again in Florida, and manatee season is over at Blue Spring State Park. We are currently featuring prior recordings. You can also scroll down the page to see other manatee videos from the web cam. Any people seen in the videos are researchers or
other individuals with special permission.
Latest Manatee Update:
July 26, 2014
I got a call from Pat Rose at Save the Manatee Club as I had missed the call from the park staff yesterday about 1:30 p.m. Pat said Annie was in the spring run and acting strange. My guess was pregnancy and calving. After a while, I decided to go the park as what I was doing I had avoided for months and could avoid for another day. Besides, if we missed filming an adoptee giving birth, we would cry. It was Annie. She had moved to dark water to eat and was hard to film. Finally she moved all the way to the boil, and I could tell she was hugely pregnant. Staff from the Florida Fish and Wildlife Conservation Commission's Research Institute arrived and agreed with my assessment that Annie wanted to calve. I stayed in the canoe watching over her and keeping people away as she took a nap. After a while, she woke up and began chewing algae off logs. Every time she rolled on her side I thought wed have a new arrival, but no. I decided it was false labor, and she would wait until dark when the run would be totally quiet. Four hours of babysitting Annie was enough for me, and I left at seven oclock. She did. I got a call from a co-worker at Save the Manatee Club, and Annie had the calf during the night. Annie and the baby are at the boil under the protection of the park.-- Wayne Hartley, Manatee Specialist
See photos and video of Annie and the new calf!
Get notification of
Blue Spring manatee updates! Join us on:
See Other Manatee Videos From The Blue Spring Manatee Cams:
1-19-14 Swimming
Echo and Unk Cavort
Manatee Aggregation
Spur and Friend Cavort
Note: Any people seen in the
videos are researchers or other individuals with special permission.
Blue Spring State Park is not open to public swimming or diving during
manatee season.
the Manatee Club is an award-winning national nonprofit
501(c)(3) and membership-based organization established in 1981 by
renowned singer/songwriter, Jimmy Buffett, and former U.S. Senator, Bob
Graham, when he was governor of Florida.
Click on the following link or the photo at left to hear a video
message from Jimmy Buffett.
Give Manatees Sanctuary in Kings Bay
Please watch the video and sign the petition to make Three Sisters Springs a true manatee sanctuary so manatees can rest undisturbed in the winter.>>
Click on the following link or the photo at left to hear a video
message about manatees and Save the Manatee Club from actor Alec Baldwin.
Special Thanks To Our
Partners On This Project:
Spring State Park,Park Manager Jerry Garrett, and the
Florida Department of Environmental Protection.
Century Link
Royal "T" Systems
Axis Communications
Blue Springs
Enterprises, Inc.

subset: commoncrawl


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[XSL-LIST Mailing List Archive Home] [By Thread] [By Date] [Recent Entries] [Reply To This Message]
Re: using multiple xsl's with one xml
Hi Carlton, > I am fairly new to XML/XSL. I need to know how to associate > different XSL files with a single XML file. For example I would like > to have a table of contents on one page and the text on another > built from the same XML doc. You *can* use multiple xsl-stylesheet processing instructions in your XML page to associated multiple stylesheets with the same XML, but no application that I know of (aside from Chris Bayes' IE extension) will actually use that. That means you have three main choices: 1. Use a script of some kind, server-side or client-side, or a batch file if you're doing a batch transform, to transform the XML with the different stylesheets. 2. Have a controlling stylesheet that imports the different views, have the templates in the different view stylesheets use different modes, and then use a parameter to choose which mode to use, and therefore which view to get. 3. Have a stylesheet that generates a stylesheet that gives the relevant view, again based on a parameter. If you want more details about any of these, ask away. Cheers, Jeni --- Jeni Tennison http://www.jenitennison.com/ XSL-List info and archive: http://www.mulberrytech.com/xsl/xsl-list
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I've featured many weddings from JL Designs here on Lost in Decoration. It's a great event planning firm in Orange County, CA with a real eye for beauty and sense of style. This tablescape was designed for a backyard party with a winter theme. I love the silver succulents!
Via: The Bedlam of Beefy
I love this carnival inspired wedding featured on The Bedlam of Beefy. This theme is a great way to show off the personality of this couple. To me this wedding says fun, playful, and casual, all the way down to the bride and groom's Converse sneakers and Keds. I also love the kissing booth and strung cafe lights. How dandy!
This Sunday evening to celebrate our independence day, I plan to attend the Liberty Belle Spectacular on the Empire Hotel Rooftop. It's sure to be one hell of an event, filled with the spirit of the roarin' '20s, and hosted by Dandy Wellington (photo above), one of those fabulous New Yorkers I'm proud to know. He was actually just featured in this great article in Time Out New York on the '20s scene around the city, which includes suggestions from Dandy of where to eat, drink, and do everything '20s.
The Liberty Belle Spectacular will include a number of great performances by the city's burlesque community and Gelber and Manning, a jazz duo famous for their Vaudevillian style and loyal following. It will be the perfect way to party like it's 1776, maybe I'll see you there! Tickets are $20 online (click here), or $25 at the door.
Be sure to also check out Dandy Wellington's Blog for more updates on the '20s scene in New York.
VIA Merci New York
One of my favorite blogs on my blogroll is Merci New York, a blog that focuses on weddings and events in New York City. Today's edition featured this shoot for Nonpareil Magazine an online publication, which was inspired by the TV series Mad Men. I'm a sucker for that show, it's probably my favorite show ever on television. I'm sure I'll be posting many of my own Mad Men inspired posts after it's season four premiere in late July!
If you haven't noticed, I'm a sucker for weddings and parties with a vintage flair. That's why I loved this wedding by JL Designs. The wedding took place at Strawberry Farms in Orange County, CA. Their flowers included ranunculas, billy balls, cone flowers, privet berries, millet, and blackberry branches.
I've always dreamed of dressing a bridal party with matching vintage hats!
Instead of large extravagant centerpieces, the couple opted for vintage inspired vignettes. This is a great way to cut on the cost of flowers and add a little personality to any event. I also love the romance of cafe lights strung haphazardly across the ceiling. I encourage you to visit JL Designs' blog for more photos of this wedding and others they have done. You won't be disappointed!


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29 Nov 2011 18:17:27
Electricity prices on Turkey's PMUM have reached a near three-month high just hours before the pool is expected to launch its fully-fledged bourse on 1 December. Traders link this both to supply disruptions to natural gas-fired generation, rising industrial demand and last minute trading ahead of the bourse launch.
The daily Baseload average for Wednesday is pegged at Turkish Lira (TL) 193.72/MWh (€77.77/MWh). The annual record was reached on 7 September when the daily medium price spiked at TL211.87, according to ICIS Heren data.
Significantly, hour 17-18 Ankara time on Wednesday reached a record TL550.00/MWh, a level that surpasses July prices, historically seen as the highest during the year.
The November average to date is TL146.17/MWh, TL50.00/MWh above last year's daily average on PMUM.
"There is so much demand on the market that we have been even able to sell at TL500.00/MWh," one participant said.
Gas supply disruption
The PMUM spikes have raised questions from participants. Some of them insist the prices are boosted by an increase in industrial consumption.
Others, however, say that ongoing supply issues on the Western Pipeline feeding natural gas to power plants on the European side of Turkey may be causing a tightness in the system.
Last week, thermal power plants operated by electricity incumbent EÜAŞ generated 3.7GW out of a total thermal installed capacity of 8.7GW, according to leaked EÜAŞ data seen by ICIS Heren, but not confirmed by the company itself.
There were suggestions that Ambarlı A and B power plants in western Turkey which have a total installed capacity of 1462MW could be either switched off or their production may be drastically reduced until March 2012. The plants have dual natural gas and fuel oil generation.
The average November price to date for fuel oil 1% FOB Barges ARA is pegged at $661.50 while the monthly average to date for fuel oil 3.5% FOB Barges ARA is $635.045, according to prices provided by ICIS.
It is thought that the natural gas generation is now switched off, while the fuel oil production is working at full throttle.
EÜAŞ could not be reached for comment.
Last-minute trading
Others explained that the spikes were a reflection of "last-minute" trading on PMUM as the pool launches its new exchange on 1 December.
From Thursday, the current transitional Day-ahead for planning platform on PMUM, the local exchange, will become a fully-fledged bourse, like the European Energy Exchange, according to a PMUM source.
Under the new arrangements, participants will have to adapt to a raft of changes ranging from a shift in the way bids are placed to the necessity to submit collateral guarantees by anyone interested in maintaining a presence on the exchange. This means that all players interested in remaining active on the bourse will be required to submit a collateral guarantee that would amount to a minimum TL200,000. AS
24 Oct 2014 21:02
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video: Inside the FAILE BĂ"ST "Deluxx Fluxx" ArcadeStreet Art // Thursday, 19 Dec 2013
During Art Basel one of the most talked about events and certainly one of our favorites was the Deluxx Fluxx arcade by Faile and Bast. For this special pop-up event, these three artists re-programmed vintage arcade games and pinball machines into sculptural works of art, as well as created an entire black light room with glowing posters and football tables to play. If you didn't get a chance to see it in person, this video will give you some perspective on how the space was constructed and the ideas behind the installation.
See more Faile work at their website


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Distributed evaluation of stochastic Petri nets
Bell, Alexander (2004) Distributed evaluation of stochastic Petri nets. In: 12th GI/ITG Conference on Measuring, Modelling and Evaluation of Computer and Communication Systems (MMB) together with the 3rd Polish-German Teletraffic Symposium (PGTS), 12-15 September 2004, Dresden, Germany.
|In this paper we present on the distributed performance evaluation and model checking of systems specified by stochastic Petri nets. The approaches discussed rely on an explicit state-space generation and target at the usage of clusters of workstations. We present results for systems with several hundreds of millions of states. For the case studies addressed, the distributed algorithms scale very well.
|Item Type:
|Conference or Workshop Item
|© 2004 VDE Verlag GmbH
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Answers related to 'baba-ramdev-kaun-the'
"Baba Ramdev had asked for permission for a Yoga camp. He held similar camps in Lucknow and Fatehpur but he gave political speeches. And you cannot mi
Asked by Francisco, 30 Apr 03:58 am
Baba 'Black Money' Ramdev caught on tape talking money with BJP candidate. But what was he hiding from media? DNA Webdesk
Asked by Manoj Kakkar, 17 Apr 07:50 pm , 1 answers
These things are very very common by politicians... more
Answered by Ataur Rahman, 17 Apr 07:57 pm
Religious people extend support to BJP openly like ramdev baba, asaram bhakt etc etc. Why BJP so angry when One imam extend support to congress? who a
Asked by samir med, 04 Apr 05:46 pm , 1 answers
When they say we r secular then why soniya does not meet,sikh guru or padris ?meeting only imam means she too is communal... more
Answered by babu rao, 04 Apr 05:53 pm
And now latest entrant is Rakhi Sawant in political arena ! is politics a running real time comedy ?
Asked by syed ilyas, 29 Mar 03:36 pm , 1 answers
With Baba Ramdev and now Rakhi Sawant, yes. It has become a circus with clowns walking every where with a lofty proud gait, often in an attempt to imp... more
Answered by QueSera Sera, 29 Mar 03:44 pm
Fun : How to ask for Tea when someone offers Pepsi or Coke?
Asked by Lucky, 28 Mar 04:01 pm , 1 answers
Seedha seedha baba ramdev wala dialogue bol do.......................ye sab toh toilet cleaners hain.....sehat k liye ache nahi hoti..................... more
Answered by Bholu, 28 Mar 04:03 pm
My wife is undergoing ATT (anti tuberculosis treatment) lungs TB . Its been 03 monts since she was dignosed. still frequently little amount of blood i
Asked by robin sharma, 18 Mar 10:38 am , 1 answers
You should she some other specialized doctors or u can go to meet Baba Ramdev for natural treatment.... more
Answered by Raj Seth, 18 Mar 10:40 am
People have over estimated ANNA HAZARE! He is just a stubborn old ex-service man with limited education and knowledge of this world... a little distur
Asked by Shunmugham, 13 Mar 12:01 pm , 1 answers
I think, in no way , Anna jee alone, can change the Indian political scenario until and unless he aligns himself to a particular political line or be... more
Answered by PARTHA PATHAK, 13 Mar 12:10 pm
How to attain yogic powers in this busy life?
Asked by nihal singh, 12 Mar 10:50 pm , 1 answers
Jai shri ram attend baba ramdev!s camps and then practice.... more
Answered by Ramesh Agarwal, 12 Mar 10:53 pm
How can you distinguish between Yog and bhog?
Asked by sanchita sarkar, 25 Jan 10:04 pm , 1 answers
It lies between Baba Ramdev and Baba Asharam, I think...... more
Answered by amitava duttamajumdar, 25 Jan 10:10 pm
Fun:- What is the difference between Kargil and Rediff?
Asked by amitava duttamajumdar, 25 Jan 09:52 pm , 1 answers
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Answered by sanchita sarkar, 25 Jan 09:56 pm
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Patrick Gavins
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Gavin to Russert: Let's Curl - Posted March 11, 2010
It's the equivalent of challenging a man to a duel. Someone steals anything, your wife, your car, your Game Changer feature, what else to do but challenge that man to a game of curling? NBC's Luke Russert took to the field for a "Game Change-ish" feature this week with Olympi... [FishbowlDC]
Politico's Gavin Pops Corks with Bill Press - Posted January 12, 2010
In Politico's Patrick Gavin's latest "Game Changer" feature, he plays a game of popping champagne corks with radio talk show host Bill Press. Gavin swigs alcohol-free champagne in the process (he doesn't... [FishbowlDC]


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ACParadise Network: American Cosplay Paradise American Cosplay Experience American Cosplay Snapshots
I went to my first con in 2003 and spent a few years just mashing costumes together using thrift stores and glue guns. Then I upgraded to buying them on ebay. I finally started sewing costumes in late '07...and I'm just now getting to the point where I like doing it; though I still think the best part of making any costume is just being done.XD Thanks to ceruleandraco for the upgrade!~
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- loli-angel-chan says, "where did you get the wig??"
- For Rose DeWitt Bukater from Titanic
- CeruleanDraco says, "*o* so pretty~ and I love your mask!"
- For Amalthea from Last Unicorn
- TATTO says, "I remember seeing this in your closet so long ago, I'm so glad you finally got to wear it! it looks so good~"
- For Sophie from Howls Moving Castle
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- For Rachel Alucard from BlazBlue: Calamity Trigger
- CeruleanDraco says, "so pretty~ i love the wig :D"
- For White Mushroom from Original Design


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Peter Foerthmann Blog
Recent Posts
- Circumnavigation # 2
- SV Marianne – Sailing Conductors – Ger
- SV Admetus – Belinda+David Sturm AT
- HR 42 Ketch – for sale – occasion – € 88.000
- Circumnavigation # 1
- SV Suditude – Jean Claude Fleuret CH
- SV Wereda – Janusz Abramowicz – USA
- SV NatHape – Nathalie + Hans Peter CH
- SV Albatros – Jos Scholten NL
- Windpilot – back to our Roots
- SV Civetta – Vlado Porvaznik SLO
- Hinckley Picnic Boat – JetStick – Tom Serrao
- SV Olgalou – Inga + Vassil Beitz GER
- SV Anne – Nette+Stefan Wendl GER
- SV Monsterpiu – Jayme Souza + Adriana Diniz Br
- Thoughts of an insider
- SV Golya – a new design of Dick Koopmans
- SV Atlantis – Inge+Ernst-Friedrich Bartels GER
- SV Olgalou – Vassilingalou
- SV Delos – 18 minutes in Indonesia
- 2014
- 2013
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Monthly Archives: F Y
SV Silver Cloud, Cory+Ovi Sacasan US
US built Pearson 40 has sustained severe damage in Hurricane IKE in 2008 – being restored by the owner and his wife during now 2 years because they had no insurance. This is their message sent 27.11.2010: Hi Peter Thanks … Continue reading
Posted in Blogs, Press Leave a comment
SV Kire, Lisa+Paul+Arne+Karl Jörn GER
SY Kire a boat, a family and 2 years time – what started as a dream some 15 years ago, became true in 2009. The aluminium built Judel Frolic 38 started from her homeport Hamburg in summer 2009, passed the … Continue reading
SV White Rose, Peter Cox UK
Swedish built Maxi 38 CC cruising in European waters since some time, passing the Canaries in winter 2010, heading West for warmer waters. Please read more about their blog here
SV Balu, Regula Gurtner+Thomas Büchi CH
Etap39 left Europe in 2009, participating the ARC 2010 and will probably passing Panama Canal in 2011, continuing westward afterwards. The boat is being fitted with a Windpilot Pacific. Please read about their adventures during their circumnavigation which is being … Continue reading
SV Selivra, Hans-Peter Maresch AUT
Jeanneau Sun Odyssey 45.2 participating at the ARC 2010 and left Las Palmas heading West for St. Lucia. If you want to hire a cabin in the Caribbean please continue and read her blog here
SV Mariposa, Annemarie+Bernhard Etter CH
Beneteau Oceanis 423 Clipper fitted with Windpilot Pacific This couple rented her home in Switzerland for some 5 years, moved onto her boat taking a fife year period for cruising in warmer surrounding. Participating the ARC in 2010, left Las … Continue reading
SV Bodyguard, Dennis Bezemer NL
DIY built van de Stadt 37 Forma started from her homeport in the Netherland in 2009, went down to the Canaries and is actually preparing for the trip to the West in winter 2010 / 2011. The boat is being … Continue reading
SV Taurus, Barbara+Christoph Einspieler AUT
Steel- Skorpion II, 37 ft on her way South, departing Germany in 2009, currently in South America, getting performed by a Windpilot Atlantik IV, stainless steel auxiliary rudder unit built in 1983, still on duty. Continue reading here please


text:
Page 102
effectiveness. Presentation to the Institute of Medicine Committee on Strategies for Small-Number-Participant Clinical Research Trials, September 28, Washington, D.C.
Zucker, D. R., C. H. Schmid, M. W. McIntosh, R. B. D'Agostino, H. P. Selker, and J. Lau. 1997. Combining single patient trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of Clinical Epidemiology 50: 401–410.
The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement
References ."
Small Clinical Trials: Issues and Challenges . Washington, DC: The National Academies Press,
2001 .
Please select a format:


text:
Jetstar Hong Kong B-KJA ntu.Now flying as VH-VFT.
New A320 for WizzAir !
to be HZ-AS17, seen here approaching runway 05 after ferryflight from TLS
Will be registered A6-ABP
C/n 3703 - RTO for him this day... To be G-EUYB
c/n 3472 Will be registered RP-C3246
c/n 3568 New livery on the tail "Best low cost airline in Asia" Will be registered 9M-AHO
Another AirAsia Special colors promoting the Award of Excellence received for being the Airlines of the Years 2007 and Best Low Cost of Asia.
c/n 3568 Special livery with title "Airline of the year 2007"
C/n 3472- New aircraft for Cebu Pacific Air... Ready for his first flight... To be RP-C3246 ;-)
C/n 3087 - Re-registrered as RP-C8604 since this pic ;-)
C/n 2947 - "V. Vereshchagin" - Another new for Aeroflot... Due to be re-registrered as VP-BQW... Special use on tail for flight test !!!


text:
Definition of strong drink in English:
strong drinkSyllabification: strong drink
Alcohol, especially liquor.
More example sentences
- He also points to a fondness for strong drink taken neat; whisky and vodka rather than English ale or Irish stout.
- I'm talking alcohol, strong drink, what the Pilgrims called 'heated waters.'
- There's a lot of Japanese folklore about strong drink, notably sake, coming to the aid of goodness.
Definition of strong drink in:
- The British & World English dictionary
Get more from Oxford Dictionaries
Subscribe to remove adverts and access premium resources
Word of the day rebuff
Pronunciation: rɪˈbʌf
reject (someone or something) in an abrupt manner…


text:
Rewrite, Sugarcoat, Ignore: 8 Ways Conservatives Misremember American History—for Partisan Gain
David Brooks and the "Vigorous Virtues"
David Brooks's column today repeats the same theme that Rubio advanced in his speech: government programs such as Social Security and Medicaid have destroyed the virtues of "self-reliance, personal responsiblity, industriousness and a passion for freedom" that Americans once possessed. Obviously, this revisionism is part of a propaganda campaign aimed at the younger generations, those who have no link to Depression-era America and what the New Deal and Great Society programs accomplished. The struggling young folks see themselves as being industrious but thwarted by lazy old folks. Youth is stiffled as retirees get ever-larger slices of an ever-shrinking economic pie. We need to fight back and educate all Americans that Social Security, Medicare and Medicaid benefit all of us, and that if these programs are cut back, we will all lose.
Asher Fried
Croton-on-Hudson, NY
Sep 2 2011 - 12:18pm


text:
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2004 Prius, no sound from stereo
Discussion in 'Gen II Prius Audio and Electronics' started by efusco, Oct 19, 2011.
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text:
Ultimate weight gain formula
The UK's lowest prices guaranteed! Found a similar product cheaper elsewhere?
We promise to beat it by 5%Use Price beater
Hard Gainer Extreme has over 440 calories per 100g serving with a high blend of 5 different protein sources with a high carbohydrate and fat content.
Hard Gainer Extreme contains a unique high protein (35g) blend comprising of 5 different protein sources which will contribute to the growth and maintenance of lean mass. This also contains a combination of low and high GI carbohydrates which include fructose, waxy maize starch and maltodextrin. In addition to these lean mass building blends, there are also added healthy sources of fat (Flax Seed) and fibre (Inulin) which make this product a healthy choice for anyone looking to increase daily calorie intake.
Hard Gainer Extreme is ideal for those looking to increase daily calorie intake and protein intake. It is recommended to consume Hard Gainer Extreme throughout the day in order to increase calorie consumption.
Add 700ml of water or milk into our shaker (the less liquid the thicker the shake will be). Then add 3 MP large scoops (100g), shake and consume. Alternatively, add 350ml of water or milk and 1.5 MP large scoops (50g). Use 1-3 times daily or as required. 1 x level MP Large Scoop weighs 35g.
Protein Blend (Whey Protein Concentrate*, Milk Protein Concentrate*, Hydrolysed Whey Protein*, Calcium Caseinate*), Carbohydrate Blend (Maltodextrin, Waxy Maize Starch, Fructose), Flaxseed Flour, Inulin (Fructo-Oligosaccharide), Cocoa Powder (chocolate and cookie & cream flavours only), Flavouring, (MCT (Medium Chain Triglycerides), Colouring (Beetroot Red [strawberry flavour only]), (Curcumin [Banana flavours only]), Sweetener (Sucralose® [flavoured options only]), Emulsifier (Soy Lecithin). *From Milk
Per 100g:
Energy: 1859kJ
Energy: 444kcal
Protein (as-is): 34.9g
Carbohydrates: 47.4g
Fat: 6.2g
(424 Reviews)
Write a review to be in with the chance to win a £100 voucher
2 out of 2 customers found this review helpful
I use this in conjunction with milk protein smooth(before bed and morning after workout), oats and whey bar (in my lunch day after a workout) and instant oats(with the milk protein). Gone through 6 kilos of this and can say it works perfectly! Used a range of my protein supplement but this one is the best so far for gaining size without any body fat! Mixes well and chocolate mint tastes amazing, perfect for after a workout! Only going off of it as I have ordered 5kg of the spectrum 12 gainer as it was on offer, so I will see which is better when I've finished that
This is the first time I've purchased this product and to be honest I'm not all that impressed. I find it very sweet which is better than being bitter, but for a weight gain drink it's too sweet (even for me and I have a very sweet tooth). I purchased the vanilla flavour and I mix it with water in a myprotein shaker (with the round spring ball). It doesn't mix well, sometimes there are little powder lumps despite shaking it for a long time and there are other little bits that float to the top and sink to the bottom so you have to shake the mixer before you drink it otherwise you'll have solids at the bottom. I'd previously tried Maxismuscle Progain and didn't have any of these problems so i'm comparing to that. Anyone else with similar experience and recommendations for other products?
1 out of 1 customer found this review helpful
The extreme hard gainer is a good product and does was it is supposed to. The only problem I have with it is that it tastes way to sweet!!
I buy this product regular wen I am bulking up on high cal intake and recommend the chocolate smooth or with mint tastes grate like all stuff on here, only thing I say to new buyers it has a texture because of the grounded oats in it but it still mixes grate with water not tried with milk, only question I have to other people that use this and the people of myprotein how many servings do you normally get out of a 5kg bag even thou I normally put an extra scoop in or egg whites???
Very good stuff would def recommend it
2 out of 2 customers found this review helpful
Have been using this with 500ml of whole milk for 3 weeks now and I've managed to gain 6lbs. Mixability isn't fantastic especially in the cookies and cream even using a blender, however is better in the mint chocolate. Tastes really good though and results are really beginning to show fast. Price is the best I've found out their and MP have excelled themselves once again.
The product is cheap and cheerful, and it just works. Takes up a meal in the day or is excellent after a work out. Very pleased.
Mixes well Tastes good Doesn't make you bloated Easy was to add quality calories to your daily intake Would recommend
Been using this for a couple of months now and I can see the benefit more compared to other whey proteins.
4 out of 4 customers found this review helpful
Ok i am skinny, I used to be quite big, never touched roids before and dont intend on doing so, want to be all natural. Events in my life a few years ago caused me to loose alot of weight but now I am on the path to getting big again. I have been taking this hard gainer extreme for about 2 weeks nearly 3. I am eating quite abit more also, I have definatly noticed a difference and I have had comments from friends who I seen over the weekend (Who I havnt seen for about 5 weeks) that I am looking more defined in my chest and shoulders...definition is not what a I want - I want to bulk but it is very early days from me starting this stuff and it is definatly helping me....I am very exited for a few months down the line....I also have the protein 5kg aswel, Taking 1 hard gainer extreme/ 2 a day on some days, with the whey impact protein once every couple days with usually two big meals and some nibbles through out the day. I also do a high calory burning job which is roofing. So this is helping me so much thanks guys ! Taste is beautiful I have chocolate , Mixes up very fast, have had some bity bits in it but doesnt bother me, When my 5 kg is done I will be getting more :D


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Catching Elephant is a theme by Andy Taylor
@mrtienforthewin birthday dinner. Love you bro #nofilter
Happy birthday @mrtienforthewin! @kanewei @stephenshi10 @thethomasliu @joshling @jkwan31
Campfire with friends to start the new year. Day 1
Happy new year #u12
Urbana worship #u12
So excited to go to #urbana that we are burning rubber #u12
Christmas dinner w00t #happybirthdayjesus
Happy birthday eric! We love you!! You are so cool.
Study party at Belo with @kanewei & @jessicakao
Jessica artwork is about to be destroyed. However the background looks pretty good.


text:
Trump picks Mrs. Giudice to bring the "Fabulicious" to Season 5.
It's a Brad, Brad World star on why he put his home life on display.
The RHOA peach hearts family life.
Who would make beautiful music with Lea Michele and Chris Colfer?
Lisa celebrates the good times of Hawaii and discusses Taylor's shocking news.
Andy Cohen recaps his holiday vacay.
Chef Roblé Ali explains that if a client wants to spend $25K on a dog wedding, it's their choice.
Brad discusses the difficulties of starting your own business and his "Diana Ross" look for the red carpet.
Dana is disappointed she wasn't invited to Hawaii, but happy she was home to support Taylor.
Gary explains why he decided to do the show.
The Bravoleb dives into ready-to-wear.
The Top Chef All-Stars champ opens HD1.
RHONJ star serves up a taste of the holidays.
Andy Cohen gives you his final three favorite moments of 2012, arm wrestling obviously included.
The RHOBH mogul has a weakness for hot artichoke dip.


text: I need to get off my duffy and lend my voice to the bardic persuits. Song 1. Mairin's Song - Lucais du Bellier Song 2-20. Any songs that mention Namron Pooky of the Wierding Way >From: Samarrah bint Annaan <samarrah_bint_annaan at yahoo.com> >Reply-To: Barony of Namron Mailing List <namron at ansteorra.org> >To: Barony of Namron Mailing List <namron at ansteorra.org> >Subject: Re: [Namron] Songs of Namron? >Date: Tue, 24 Apr 2007 10:18:01 -0700 (PDT) > >I have an original peice about Namron that I'll sing at Beltain. > >Lady Samarah Basimah Latifa al Dhakira bint Anaan bint Mellilah > >God be with you in every pass. Jesus be with you on every hill. Spirit be >with you in every stream, headland, ridge and law, each sea and land, each >moor and meadow, lying down and rising up,in the trough of the waves or on >the crest of the billow. Each step of the journey you go, go with God. > > >----- Original Message ---- >From: Lord Pooky <lord_pooky at hotmail.com> >To: namron at ansteorra.org >Sent: Tuesday, April 24, 2007 9:29:42 AM >Subject: [Namron] Songs of Namron? > > >Hello my lovelies and lords, > >I was at Wiesenfeuer Baronial tossing fruit and screaming (frightened) >turkeys at rapier fighters last weekend. Then scampering off their list >field while flailing my arms and squealing like a frightened girl. (best I >could at least) > >Something occurred to me while this moment in time was being serenaded by >Wiesenfeuer's Bardic Champion. > >What songs of Namron have been written? >He was singing a well known sing-a-long about Mooneschadowe and I was >wondering what Namron songs were already out there. > >Thank You, >Pooky > >Ah yes, 3 from Baron Uriah Wolfstar just came to mind. Anyone know others? > > >_______________________________________________ >Namron mailing list >Namron at ansteorra.org >http://lists.ansteorra.org/listinfo.cgi/namron-ansteorra.org > >__________________________________________________ >Do You Yahoo!? >Tired of spam? Yahoo! Mail has the best spam protection around >http://mail.yahoo.com >_______________________________________________ >Namron mailing list >Namron at ansteorra.org >http://lists.ansteorra.org/listinfo.cgi/namron-ansteorra.org


text:
but they did
or Nintendo characters
but they did
Ka-Toro rulz!!
not want to
please come join my Kingdom Hearts RP http://www.wiichat.com/board-games/6...p-sign-up.html
Romans 14: 10-12
10.You, then, why do you judge your brother? Or why do you look down on your brother? For we will all stand before God's judgment seat.
11.It is written: " 'As surely as I live,' says the Lord, 'every knee will bow before me; every tongue will confess to God.'"
12.So then, each of us will give an account of himself to God.
die so they
Ka-Toro rulz!!
disguised them selfs
(from the fox)
as police because
I've returned.
Untill one day
they got revived
KingBowser & BowserJr.


text:
mailing list archives
I have to agree with Theo that this is a sad situation. At first glimpse
it seems odd that more people didn't get up in arms about it. But upon
further reflection, one realizes that it's pointless to get irate with
people who have just demonstrated that they are zombies anyway.
Open Group, when *will* the rest of us see at least some clues about where
the bug lies and how it can be fixed? You say you won't release patches
to X11R<6.4, but can you at least be nice enough to tell those of us using
the still-perfectly-serviceable 6.3 just a tidbit about the problem?
Jeff Gehlbach http://pobox.com/~jeffg/
jeffg () pobox com +1 256-766-5977 +1 256-33-LINUX
By Date
By Thread


text:
Pasquale's Pizza & Pasta Cafe
505 Bedford Ave. Bellmore, NY 516-679-3661
Critic rating:
This pizzeria and restaurant specializes in various Italian entrées and pizza pies available for lunch and dinner, and generally serves a crowd of local diners from the community.Hours: 11 a.m.-10 p.m. Monday-Thursday; 11 a.m.-11 p.m. Friday-Saturday. Noon-9 p.m. Sunday. Ambience: Good Service: Good Credit cards: Accepted Accessibility: Wheelchair accessible


text:
You wanted to find out about how can i sexphoto from cuba, here are some of our members, why not join today for FREE;
Our aim is to be the premier place for singles search looking for a naked boyfriend or a wife or girlfriend. We are not like traditional dating agency scotland offering matchmaking and personals, we provide a venue to sexy chat and find someone who likes making love and romance sex which may or may not end up with marriage and sex.
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text:
Trompe L'oeil
The artist recreates a realistic depiction of the torn paying card, paying attention to the right color and shadow definition of its counterpart.
"Realism Challenge: Playing Card" Artist. Mark Crilley
I learned this, hell yeah haha
this has shown up on my dash today more than 10 times already so i'm just going to reblog it because i'm still always impressed


text:
Find out the truth behind common myths about bioidentical hormones.1: All estrogens are the same.
False. This is the most important question in relation to estrogen. The type of estrogen given to the body determines how the body will react and respond. The body makes three principle estrogens: estradiol, estrone and estriol. All three are present in the body of women before (and after) menopause. Estradiol is the workhorse of the estrogens. Estriol is now being looked at as a potential anti-inflammatory estrogen with benefits to illnesses like multiple sclerosis [Source: Sicotte]. Higher ratios of estriol have been linked to lower levels of breast cancer [Source: Lemon]. Each of these forms of estrogen are made in the body. They do have slight variations with some of the forms of estrogen used in Western medicine. Premarin is a form of estrogen collected from the urine of horses. This collection of estrogens is similar but not necessarily identical to the ratio the body makes. Experts argue that this exception to what the body makes is what creates the problems seen with traditional hormone replacement. Greater attention is now being paid to study and utilize hormones made identical to those of the body, referred to as bioidentical hormone replacement.


text:
Astigmatism Center - Bowie, MD
WebMD Physician Directory
Bowie, Maryland
What is astigmatism?
Astigmatism is an irregularity in the way light is focused (refracted) by the eye. Most commonly, astigmatism is a result of variations in the curvature of the cornea of the eye. However, astigmatism can also be caus...
Emergency Contact for Bowie
Nearby Bowie Hospitals *
Doctors Community Hospital
Prince George's Hospital Center
Anne Arundel Medical Center
Laurel Regional Hospital
Clifton T Perkins Center
The HSC Pediatric Center
Malcolm Grow Med Ctr 79Th
Saint Luke Institute
Providence Hospital
Seton House Providence Hospital
Baltimore Washington Med Center
Washington Adventist Hospital
Specialty Hospital Washington
Washington DC VA Medical Center
Washington Hospital Center
Children's National Medical Ctr
Medstar National Rehab Hospital
King Health Center
Howard University Hospital
Saint Elizabeths Hospital
United Medical Center
Holy Cross Hospital
Southern Maryland Hospital Ctr
George Washington Univ Hosp
Speciality Hosp Of WA-Hadley
Psychiatric Institute
Georgetown University Hospital
Walter Reed Ntnl Mltry Med Ctr
Howard County General Hospital
Sibley Memorial Hospital
NIH Clinical Center
Suburban Hospital
Sheppard Pratt Ellicott City
Fort Washington Medical Center
Halquist Memorial Inpatient Ctr
Medstar Harbor Hospital
Spring Grove Hospital Center
Virginia Hospital Center
Montgomery General Hospital
Inova Alexandria Hospital
Saint Agnes Hospital
Regional Institute For Children
Mountain Manor Treatment Center
Bon Secours Baltimore Hlth Sys
Dominion Hospital
University Maryland Medical Ctr
Baltimore VA Medical Center
Inova Mount Vernon Hospital
Mercy Medical Center
Kernan Hospital
Maryland General Hospital
Metropolitan Transition Center
John Hopkins Hospital
Johns Hopkins Bayview Med Ctr
Kennedy Krieger Institute
Kimmel Cancer Ctr Johns Hopkins
Adventist Rehab Of Maryland
Medstar Union Memorial Hospital
Shady Grove Adventist Hospital
Adventist Behavioral Health
Inova Fairfax Hospital
Northern Virginia Mental Health
Levindale Hebrew Hospital
Sinai Hospital Of Baltimore
Northwest Hospital Center
Dewitt Army Community Hospital
Mt Washington Pediatric Hosp
Good Samaritan Hospital
Calvert Memorial Hospital
Sheppard Pratt Hospital
Med Star Franklin Sq Hosp Ctr
Greater Baltimore Medical Ctr
St Joseph Medical Center
Springfield Hospital Center
Civista Medical Center
*Provider Directory Terms of Use:
The WebMD 'Provider Directory' is provided by WebMD for use by the general public as a quick reference of information about Providers. The Provider Directory is not intended as a tool for verifying the credentials, qualifications, or abilities of any Provider contained therein. Inclusion in the Provider Directory does not imply recommendation or endorsement nor does omission in the Provider Directory imply WebMD disapproval.


text:
Responsible working professionals seek 2 or 3 bed/2 bath tenement in G3/G20/G11/G12 areas
Hello. I am a 37 year old lecturer looking for a quality, furnished 2 or 3 bed/ 2 bath tenement in the west end of Glasgow. I am very responsible, fastidiously clean and tidy and am a landlord myself, so fully appreciate the importance of looking aft


text:
The Nashville Predators re-signed defenseman Joe Piskula to a one-year, two-way contract on Friday.
Acquired from the Calgary Flames in February of 2013 in exchange for enforcer Brian McGrattan, the blueliner spent most of the 2013-2014 season playing with the Predators top minor league club, the Milwaukee Admirals. Joe Piskula put up 23 points in Milwaukee and was called up for two games at the NHL level last campaign.
The 30-year-old will serve as the veteran presence on the Admirals blue line and play in a pinch with Nashville as injuries or other factors dictate. A Wisconsin native, the defenseman signed his extension with the Predators not only on Independence Day (United States) but also the day before his 30th birthday.
Hockey's Future describes Piskula as such:
Piskula is a defensive defenseman with good size. For a man who is 6'3″ and 212 pounds, he skates remarkably well with deceptive speed and can move the puck quite effectively. His smart, sound defensive zone play and great mobility are two of Piskula's attributes that have gotten many in the scouting community taking notice.
Below is the Predators official press release:
Nashville Predators President of Hockey Operations/General Manager David Poile announced today that the club has signed defenseman Joe Piskula to a one-year, two-way contract worth $550,000 at the NHL level and $150,000 at the AHL level.
Piskula, 29 (7/5/84), played a pair of games for the Predators in 2013-14, and has suiting up for 12 NHL games with Nashville, Calgary and Los Angeles since 2006-07 (0g-0a-0pts, 8 PIMs). The Antigo, Wisconsin native spent the majority of last season with Nashville's primary developmental affiliate, the American Hockey League's Milwaukee Admirals, posting 23 points (3g-20a), 56 penalty minutes and a +20 rating in 73 games. Acquired from the Flames organization on Feb. 28, 2013, Piskula has appeared in 466 AHL games over the past seven seasons, amassing 97 points (12g-85a) and 391 penalty minutes.
The 6-3, 208-pound blueliner signed with the Kings after three seasons at the University of Wisconsin from 2004-07 where he compiled 22 points (3g-19a) and 80 penalty minutes in 112 games and helped Wisconsin win the 2006 NCAA national title.
Thomas Willis is the Manager/Editor of Predlines.com and can be reached at [email protected]. For the latest updates in Predator news, follow @PredlinesNSH


text:
4-Creativity supports language and literacy development-By engaging in creative play or projects,
There are four components of creativity as described by Psychologist Ellis P. Torrance: fluency, flexibility, originality, and elaboration.
Flexibility is the ability to approach different situations and develop solutions from a number of different perspectives. Foster flexibility by allowing plenty of opportunities to explore and experiment. Allowing children to experiment and make mistakes unleashes their creative thinking and a sense of wonder. They feel free to imagine, invent, create, and try out new ways to do things. Asking questions during an activity or when a problem arises such as "how is another way we could do this or solve it?" encourages children to think outside of the box.
Originality is the ability to have a new or novel idea. To promote originality, provide a variety of supplies and experiences in which children can use their imagination and create. By painting or constructing something out of play dough they are creating something out of nothing.
Elaboration is the ability to extend ideas. Give children new ways of doing old ideas and activities. For instance, providing pipe cleaner and other items to stick into play dough would allow children to elaborate in their play.


text:
Cooperative Huntington's Observational Research Trial
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to collect prospective data from individuals who are part of a Huntington Disease (HD) family, in order to relate phenotypes between individuals and families with each other and genetic factors in order to learn more about HD, develop potential treatments for HD, and to plan for future research studies of experimental drugs aimed at slowing or postponing the onset and progression of HD.
Huntington Disease
|Study Type:
|Study Design:
|Time Perspective: Prospective
|Official Title:
|Cooperative Huntington's Observational Research Trial
Blood, DNA and Urine
|Estimated Enrollment:
|Study Start Date:
|February 2006
|Estimated Study Completion Date:
|December 2020
|Estimated Primary Completion Date:
|December 2020 (Final data collection date for primary outcome measure)
COHORT (Cooperative Huntington Observational Research Trial) is a coordinated research effort by Huntington Study Group research centers worldwide to prospectively collect data from consenting individuals who are affected by Huntington's disease (HD) and who are part of an HD family. The systematically accrued data from annual prospective assessments will relate clinical characteristics (phenotypes) between families with genetic and environmental factors. The knowledge from these relationships will better inform us about the onset and progression of HD, help identify potential interventions for HD, and aid in planning research studies of experimental treatments aimed at slowing or postponing the onset of HD. The consented collection of biological samples will further provide research material and correlative data for scientists to identify biomarkers that parallel the development and progression of HD. Identification of biomarkers will in turn contribute to our understanding of HD and enhance the efficiency and power of disease-modifying therapeutic trials.
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
- An individual of any age that is affected by Huntington's disease
- An individual 18 years of age or older, who has tested positive for the HD gene
- An individual 18 years of age or older who is a parent, sibling or child of an individual affected by HD
- An older adolescent 15 to 17 years of age, who has a parent affected by HD enrolled in COHORT, or a parent who has tested positive for the HD gene enrolled in COHORT (at select sites)
- Grandparents and grandchildren of anyone participating in COHORT who fulfills the requirements of (the above) category (1) or (2)
- HD family members who have no risk for HD due to no family history (spouses or caregivers)
- HD family members who have undergone DNA testing and does not carry the genetic mutation responsible for HD.
Inclusion Criteria:
- (1) MANIFEST/PRE-MANIFEST HD: Individuals of any age who are affected by HD OR an individual 18 years or older who - has tested positive for the HD gene.
- (2) INDIVIDUALS AT RISK: An individual 18 years or older who has not undergone DNA testing for the mutation responsible for HD and who is a first degree relative (parent, sibling, child) of an individual with Manifest or pre-manifest HD OR an older adolescent 15 to 17 years of age who has a parent with manifest HD or pre-manifest HD enrolled in COHORT.
- (3) ADULTS AT SECONDARY RISK: An individual 18 years of age or older who has not undergone DNA testing for the mutation responsible for HD and is a grandparent or grandchild of an individual enrolled in COHORT who has manifest HD or pre-manifest HD
- (4) CONTROL: A spouse or caregiver, 18 years of age or older, of an individual enrolled in COHORT who has manifest HD or pre-manifest HD
- (5) ADULT GENE NEGATIVE: An individual, 18 years of age or older, with a family history of HD who has undergone DNA testing and does not carry the genetic mutation responsible for HD.
Exclusion Criteria:
- (1) Anyone who does not fit the inclusion criteria
Please refer to this study by its ClinicalTrials.gov identifier: NCT00313495
|Contact: Huntington Study Group
Hide Study Locations
|United States, Alabama
|University of Alabama at Birmingham
|Birmingham, Alabama, United States
|United States, California
|UCLA School of Medicine
|Los Angeles, California, United States
|Contact: Angeline Gratiano 310-206-2154 firstname.lastname@example.com
|University of California, Davis
|Sacramento, California, United States
|Contact: Nicole Mans 916-734-3541 firstname.lastname@example.com
|University of California, San Diego
|San Diego, California, United States
|Contact: jody goldstein 858-622-5854 email@example.com
|University of California, San Francisco
|San Francisco, California, United States, 94143
|Contact: Jonathan Gooblar, BA 415-476-1686 email@example.com
|United States, Colorado
|Colorado Neurological Institute
|Littleton, Colorado, United States
|Contact: Diane Erickson 303-762-6674 firstname.lastname@example.com
|United States, Connecticut
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|Graylands, Selby-Lemnos & Special Care Health Services
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|Contact: Steve Andrew 618 9347 6464 firstname.lastname@example.com
|Canada, Alberta
|University of Calgary Medical Clinic
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|Canada, British Columbia
|University of British Columbia
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|Contact: Allison Coleman 604-822-7739 email@example.com
|Canada, Manitoba
|Movement Disorders Clinic, Deer Lodge Centre
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|Contact: Sandra Funk 204-940-8547 email@example.com
|Movement Disorder Clinic Deer Lodge Centre
|Winnipeg, Manitoba, Canada
|Contact: Sandra Funk 204-940-8547 firstname.lastname@example.com
|Canada, Nova Scotia
|Halifax Infirmary
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|Contact: Joanne Courtney-Walker 902-473-8261 email@example.com
|Canada, Ontario
|London Health Sciences Centre
|London, Ontario, Canada, N6A 5A5
|Contact: Emilija Makaji, MSC 519-685-8500 ext 36893 firstname.lastname@example.com
|The Centre for Addiction and Mental Health
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|Contact: Irita Karmalkar 905-472-7082 ext 229 email@example.com
|Canada, Quebec
|Hotel-Dieu Hospital-CHUM
|Montreal, Quebec, Canada
|Contact: Suzanne Paris 514-890-8000 ext 26511 firstname.lastname@example.com
|Principal Investigator:
|Ira Shoulson, MD
|University of Rochester/Huntington Study Group
Additional Information:
No publications provided by HP Therapeutics Foundation
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Ira Shoulson, MD/Principal Investigator, University of Rochester
|ClinicalTrials.gov Identifier:
|NCT00313495 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 10, 2006
|Last Updated:
|March 4, 2011
|Health Authority:
|United States: Institutional Review Board
Keywords provided by HP Therapeutics Foundation:
Huntington disease, observational, family members, biomarker
Additional relevant MeSH terms:
Huntington Disease
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Cognition Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Genetic Diseases, Inborn
Heredodegenerative Disorders, Nervous System
Mental Disorders
Movement Disorders
Nervous System Diseases
Neurodegenerative Diseases
ClinicalTrials.gov processed this record on October 23, 2014


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From an editorial in Tuesdays Washington Post:
Former Sen. Jim DeMint, R-S.C., now leader of the Heritage Foundation, knows that the nonpartisan Congressional Budget Office is likely to judge that immigration reform including eventual citizenship for millions of undocumented immigrants will be a shot in the arm for the U.S. economy. After all, the CBO has done so with previous such legislation. That explains why Mr. DeMint, a bitter opponent of legalization, has launched a preemptive attack on the CBO puppets of the Congress, he called the office the other day and why Heritage has issued a study slamming amnesty for unauthorized immigrants as a drain on taxpayers.
The Heritage paper, chock-full of assumptions that most economists dispute, is a blatant attempt to twist the immigration debate. It concludes that newly legalized immigrants would cost $6.3 trillion more in benefits over their lifetime than they would pay in taxes. The study updates a similar one by Heritage in 2007, which pegged the fiscal cost of amnesty at that time at $2.6 trillion.
Theres no question that granting the full range of government benefits to illegal immigrants even if they become eligible for citizenship 13 or 15 years from now will impose long-range fiscal costs. However, most economists say the costs of illegal immigration would be far outweighed by the benefits of legalization for overall economic activity, growth, business start-ups and labor market efficiency.
Thats not news for the construction industry in Arizona, where hostile state laws have driven away thousands of illegal immigrants and builders have scrambled to find scarce workers. Its not news on farms from coast to coast, where more than half the labor force lacks documents and growers worry that their crops will go unpicked without a system to legalize unauthorized migrant workers.
The authors of the Heritage study acknowledge that the population of illegal immigrants, most of whom lack high school diplomas, would impose no greater burden on the budget than native-born Americans and legal immigrants with similar educational levels would. What Heritage really objects to is redistributive government programs, which one of the studys authors termed Americas cradle-to-grave welfare state.
Influential Republicans, including Rep. Paul Ryan of Wisconsin, Sen. Marco Rubio of Florida and former Mississippi Gov. Haley Barbour, rolled their eyes at the Heritage report with politeness. In a letter to Heritage, Mr. Rubio, who has risked his political future to champion immigration reform, noted that the real impact of legalization and citizenship must take into account both its baseline costs and its impact on growth. Mr. Barbour, who doesnt appear to be running for anything, could afford to be more blunt. Its a political document, he wrote on Twitter. Its not a serious analysis.
Thats true, as the CBO is likely to make clear when it publishes what is certain to be its more dispassionate, and less political, assessment of the proposed legislation. Meanwhile lawmakers should bear in mind that waves of previous immigrants Irish, Italians, Jews, Germans and others have been greeted by prophesies of doom. Still, the United States thrived with the help of those same poorly paid, roughly educated newcomers whose integration triggered such derision.
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Problems of Rationality
moreProblems of Rationality is the eagerly awaited fourth volume of Donald Davidson's philosophical writings. From the 1960s until his death in August 2003 Davidson was perhaps the most influential figure in English-language philosophy, and his work has had a profound effect upon the discipline. His unified theory of the interpretation of thought, meaning, and action holds that rationality is a necessary condition for both mind and interpretation. Davidson here develops thistheory to illuminate value judgements and how we understand them; to investigate what the conditions are for attributing mental states to an object or creature; and to grapple with the problems presented by thoughts and actions which seem to be irrational. Anyone working on knowledge, mind, and language willfind these essays essential reading. less
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text:
The TRUTH behind Microsoft Azure's global cloud mega-cock-up
Windows Azure suffered a global meltdown at the end of October that caused us to question whether Microsoft had effectively partitioned off bits of the cloud from one another. Now we have some answers. After a bit of prodding, Redmond sat us down with Windows Azure general manager Mike Neil, who explained to us why a sub- …
It seems odd to me that if this system can only have a single front end... it's doing something else (scheduling or moving jobs maybe) that is not really the job of a front end. Hopefully it's not an indicator of further architectural faults.
I was going to insert a Microsoft bash, but *shrug*. It's true, it takes time to work out the bugs on complex systems. IBM mainframes are reliable as can be *now* (and probably the last 30-40 years), but they apparently also had crashes aplenty through the 1960s and 1970s.
Re: Wow...
"There are three truths of cloud – machines will fail, software has bugs, people will make mistakes,"
So it would seem this one goes down as a people mistake, as only a person could of designed Azure so that there was only one functioning RDFE worldwide at any one time.
Re: Wow...
Azure doesn't have a single Front End or a single Point of Failure in this regard.
Multiple systems were updated with the problematic software...Potential for a similar issue exists in any cloud system with a consistent OS, fabric, controller, firmware, etc, etc...
Perhaps roll outs should have been cascaded globally on a slower basis, etc, but that still doesn't make it a single point of failure....
Re: Wow...
"...only a person could of designed Azure..."
...only a person could HAVE designed Azure... I'll put that down as a people mistake :-)
The fabric controller started spewing gibberish?
Re: Soooooooooooooooo
Quick!! Give it a job in marketing!
GM Foods
Be thankful.
If this was a genetically modified food rollout, they wouldn't be able to do a recall, and it would self replicate.
You may make bugs and failures in software and hardware but at least you can do product recalls and upgrades.
Asparagus apocalypse is real and it's coming to a farm near you!
Re: GM Foods
If this was a genetically modified food rollout,
Okay, completely different industry, but let's see where this goes...
they wouldn't be able to do a recall,
Yes they would. See, for example, http://en.wikipedia.org/wiki/Starlink_corn_recall and http://www.organicconsumers.org/gefood/canolarecall.cfm
and it would self replicate.
Seasonally, at a pace which would allow for relatively easy control.
All of this ignores the fact that GMO are much more regulated that software and tech. services. See http://en.wikipedia.org/wiki/Regulation_of_the_release_of_genetically_modified_organisms for starters.
@Steve Knox - Re: GM Foods
Regulated my leg! Tell Monsanto about that!
Re: GM Foods
Ah, it's not likely that could ev... Oh, Fuuuu...
Re: GM Foods
They issue the recall, the GM crop just continues to produce seeds regardless. It's almost as if the duplication mechanism doesn't care about the recall notice.
You can't stop invasive plants spreading across Britain, so you can't stop invasive GM plants either.
"GMO are much more regulated that software"
Create a law making it illegal for invasive species to spread across Britain, does it work? Of course not, they're just words if there's no way to enforce those words.
Re: GM Foods seasonally?
seasonally alas no - once the change gets into other plants then they can replicate it every few weeks.
And recalling grain in grain elevators is of no use when its in the wild plant population. GM modifications have been found in almost all wild maize in Mexico.
Re: GM Foods
> You can't stop invasive plants spreading across Britain, so you can't stop invasive GM plants either.
Is there a need? Won't these plants just die on their arse when challenged by the natural variety in their usual habitat?
Re: GM Foods
> http://www.cracked.com/article_18503_how-biotech-company-almost-killed-world-with-booze.html
Haha! This is like Frederik Pohl's "Shaffery Among the Immortals".
Analysis that's not from the weekend science press requested. One would suppose that this kind of trick might be found by mother nature a few times per day, greygooing your garden through purely natural means (100% green!). That doesn't routinely happen though. Maybe it just happens every 300 years...
Re: @Steve Knox - GM Foods
> Tell Monsanto about that!
Re: GM Foods
It would be very interesting to know if the three up votes for Steve Knox came from an IP address range belonging to Monsanto...
Re: GM Foods
"> You can't stop invasive plants spreading across Britain, so you can't stop invasive GM plants either.
Is there a need? Won't these plants just die on their arse when challenged by the natural variety in their usual habitat?"
I wouldn't bet my house on that, especially if the GM variety is specifically engineered to be more resistant to a pests/diseases and pesticides. Of course if the variety is also engineered to grow faster or yield more heavily the chances are it will starve the native species of sunlight. This kind of thing happens already with varieties bred by more traditional methods.
Re: GM Foods
Is there a need? Won't these plants just die on their arse when challenged by the natural variety in their usual habitat?
Like Japanese Knotweed, American Stink Cabbage, Himalayan Balsam to mention just three?
One of the problems with these invasive plants is that the insects which would normall be expected to devour them haven't yet been imported/designed.
Re: GM Foods
>> Seasonally, at a pace which would allow for relatively easy control.
Yes, like mosquitos.
Re: GM Foods
Is there a need? Won't these plants just die on their arse when challenged by the natural variety in their usual habitat?
Often, yes, in which case there's no problem. But also often, no, because they find a niche to which they're already well-adapted; or no, because the ecological processes that formerly prevented species with similar adaptations from establishing themselves have been disrupted.
The last is what happened with prairie grasses in most of the US grasslands, for example. They are typically tall, slow-growing plants with very deep root systems. When established, they block most of the sun from fast-growing invasives; the ones that aren't controlled that way generally were done in either by drought (didn't have the roots to survive it) or burn-off. Burn-off, caused by lightning strikes, was particularly important - the native grasses could burn to the ground and regrow quickly from their root systems, while the burn would wipe out other plants.
When people started building permanent dwellings, cutting down the tall grasses, irrigating fields, and suppressing wildfires, the European invasive plants they brought (because guess which people these were) easily found niches in the modified ecosystem.
Invasive-species ecology is a whole complex field of study. Many people have made careers out of a single species (Asian carp, kudzu, Formosan termites ...).
Re: GM Foods
Yeah, that was one that 'could've happened', but luckily, didn't.
Here's one that did: Native rapeseed weeds gain immunity to herbicides from closely related GM canola plants.
I'm not against GM crops where the changes enhance the quality or nutritional value of crops, but changes that're simply for the benefit of herbicide companies, or rendering vital foodstocks sterile to ensure the value of patents (Seriously, no patents for living things, ya greedy bastards!) should be a big no-no!
"One of the most difficult problems for us to address ... is the software itself,"
This ... from a software company.
Re: Really?
"This ... from a software company."
No, Microsoft !
Release procedures
So they tested their new software on a few servers, then hit the big button to roll it out worldwide at once? I've never run an operation the size of Azure, but I'm fairly certain I wouldn't do everywhere all at once.
Read the news reports of Google, Amazon & Facebook releasing new features, and you see them slowly release their new features across their different geographical locations.
Re: Release procedures
@ A Non e-mouse
As the Microsofty said in the article, they have to run just the one instance of this front end of theirs. So effectively there is only one region for Azure as regards the front end.
Perhaps a larger sample for testing will be used next time.
Re: Release procedures
Sure, but Google, Amazon, and Facebook don't have three big teams of office cleaners, the first tasked to write software, the second with system administration, and the third walks around Redmond campus with brooms ...
I wonder how many more single-point of failures they have architectured into this crapCloud™ - we already had the two certificate cock-up's.
BTW, I live in a place called "Cote d'Azure" ... nothing to do with Redmond Washing, though.
Re: Release procedures
Erm, you know Azure has had fewer major outages than Amazon?
Re: Release procedures
"they have architectured"
Please go and wash your mouth out!
Azure asked for it - front end 'bricked it'
As someone experienced producing bootloaders for flash-based embedded systems - you never make your
'frontend' (the bootloader/firmware updater/configurator) depend in any way on the application (what the bootloader is supposed load and run), because if the application fails, then you've no way to update the system - hence 'bricking it'.
This lack of separation would be painfully obvious to anyone developing low-level firmware - because if you make this mistake, it'll only be once in your lifetime and you'll and never ever forget it. Surprising that a company of MS's monstrous size can make such elementary design error on such a huge system.
We're new to this sort of thing, but think we know better than everyone else.
"Red Dog Front End"
Somehow I always recall the phrase from the film "Ransom," of a "Lying assed dog."
Funny how memory works?
proof that microsoft really don't have a fucking clue what they're doing
It also means that there is still a single point of failure in their system...
So what else is new? They can't program for reliability at all.
How many worldwide wobbles are we up to now?
If I could be bothered to go back over the headlines I could find out but they seem to be a fairly regular occurrence.
Re: How many worldwide wobbles are we up to now?
... don't they claim 99.999% uptime.
... starting 2020
Re: How many worldwide wobbles are we up to now?
Already posted this once, for some reason it didn't make it!
I think we're up to 2 or 3 this year, 2 major ones which caused a lot of downtime. This one was just a deployment inconvenience, not even remotely a "meltdown", but definitely a "cock-up"
Complex, distributed global systems are hard, no surprise there. All cloud providers have had down time in recent years, it would be useful if someone kept a tally of number/severity of outages so we could see who was faring worse.
"Cloud" is a trade off, you exchange the convenience of not having to deal with managing your own infrastructure for potentially less up time if their systems have problems. To me this is a worthy trade-off, to others possibly not.
Single Point of Failure
"One of the most difficult problems for us to address which creates a single point of failure in the system is the software itself," Neil said.
If this is the case then the real single point of failure lies somewhere in the management who let this architecture loose. I've worked in several large hosting environments, and the idea that you'd rely on a software based solution to manage access to all server instances without massively comprehensive and time consuming testing of new versions of the software smacks of poor risk management and trying to do things on the cheap - a complete no no for this type of service.
But hey! The cloud is the latest cool IT trend! My boss read in a magazine that everybody has to move to the cloud!
Re: Single Point of Failure
>My boss read in a magazine that everybody has to move to the cloud!
Same here ...
Sad, sad world ...
Re: Single Point of Failure
"One of the most difficult problems for us to address which creates a single point of failure in the system is the software itself," Neil said.
It would seem that this proves the wisdom in using software developed by different teams...
Re: Single Point of Failure
"If this is the case then the real single point of failure lies somewhere in the management who let this architecture loose. I've worked in several large hosting environments, and the idea that you'd rely on a software based solution to manage access to all server instances without massively comprehensive and time consuming testing of new versions of the software smacks of poor risk management and trying to do things on the cheap - a complete no no for this type of service."
mmmm .... I do not think the reason for the failures is as simple as this
We have many servers in Azure and they continued to work. No one has reported to me any downtime for our customers I have to report to them.
I am surprised if the Pink Poodle is the same installation for all of their groups of servers, and so perhaps one or two were fucked but others weren't. But I am speculating.
Re: Single Point of Failure
Not really, because you still have a single system, if it's developed by different teams or not. This is what he is getting at - the software itself is an individual system, therefore it represents a single point of failure. Albeit one which an extraordinary amount of effort has been made to make it not reliable. The only way you're going to get out of the software as a SPOF is if you take an Aeroplane style development system where you have different code written on different hardware and using different languages in a voting system, but this is obviously overkill and going to be extremely expensive for a cloud based system.
This will continue to happen as there is a fault in the implimentation of NSPOF.
"Due to the way Azure is built, there can only be one RDFE functioning worldwide at any one time"
Why do some companies never do things right? Is it that they can't be arsed or is it "good enough" to earn some cash?
"...infrastructure that scales"
...the bugs scale too, apparently.
infrastructure that scales
Infrastructure that scales.
Re: infrastructure that scales
Oh very good sir. May your skies be cloudless
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