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Online trolls say crash was MY fault, says cyclist kicked to the ground on Embankment
A cyclist who was kicked to the ground by a BMX biker as he rode through central London said today he is facing a barrage of abuse from people who think he is to blame.
One man stabbed and another found injured on nearby bus after fight in west London
One man was stabbed and another injured after a fight in west London this morning, police said.
Alice Gross funeral: Mourners say final poignant farewell to murdered schoolgirl in Hanwell
Crowds of mourners gathered today to say a poignant farewell to murdered schoolgirl Alice Gross as her funeral cortège passed through the streets near her home.
Bonus bonanza for City 'super' bankers
Published: 10 January 2014
Updated: 11:39, 10 January 2014
London's highest flying "superbankers" are set for multi-million-pound windfalls in the last-ever bumper bonus round for the City's big hitters.
The return of mega-deals — led by Vodafone's £84 billion sale of its US mobiles division — and big stock market share issues resulted in huge fees for a handful of leading banks and vast bonuses for their elite "rainmakers", say City insiders.
The top investment banks such as Goldman Sachs and JP Morgan reveal the size of their pay and bonus pots for 2013 over the coming weeks. City sources told the Standard that the top players can expect bonus payouts between 10 and 15 per cent up on last year.
But for the majority, bonuses will be at best the same as in 2012, with many seeing falls and a sizeable minority ending up with a "doughnut" — City slang for a bonus of zero.
One source said: "You're seeing the emergence of superbankers — an elite who make a fortune while the rest are left pretty disappointed. Make no mistake, the cream of the crop will do very well. There is just less cream and there will be more doughnuts than ever."
For big banks it will be the last time they can award bonuses many times bigger than salaries. New European laws capping them at 100 per cent of base pay, or 200 per cent with shareholders' consent, came into force on January 1.
Those in line for payouts of between £3 million to £6 million are said to include Karen Cook, president of Goldman Sachs in Europe, Geoff Austin of new boutique investment bank Moelis and JP Morgan investment banking chiefs Ina De and Viswas Ragavan.
One feature of this year's bonus round is the number of senior women in line for huge payments. Another of the London "superbankers" with outsize bonuses worth millions of pounds will be Marisa Drew of Credit Suisse.
Also heading for a big payout is Lucy Baldwin, who at the age of just 28 is already one of the most powerful analysts at Goldman Sachs
Nerves are running high in the City and Canary Wharf as with the approach of bonus season — a time of ferocious lobbying of department heads. Goldman Sachs kicks off the "season" with the announcement of its 2013 results on Thursday.
Those working for the other big US banks find out in the next fortnight how much they earned, with European rivals announcing in early February.
City sources said the biggest earners on takeover deals are likely to be those who advised on Vodafone's sale of its stake in the US mobiles giant Verizon.
UBS's former deals kingpin Simon Warshaw and Goldman's Cook are likely to pocket several million dollars for that one transaction alone.
Top staff at Moelis will be paid handsomely for the £21 billion merger of advertising giants Publicis and Omnicom and the £1.5 billion takeover of Co-op Bank by its bondholders.
Overall, however, many banks continue to struggle to make the mega-profits of the pre-Lehamn Brothers boom years. Bonuses will reflect that.
A City headhunter said: "Goldman's corporate finance department had a record year but its trading division did badly, so the bonus pool is hit for everyone. It's the same everywhere."
The huge fines that hit banks such as JPMorgan, which lost £3.6 billion in the London Whale trading fiasco, will also reduce the overall bonus pot.
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Claudie Pierlot opens fifth London store
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WIN tickets to the Midtown Big Ideas Exchange event
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How they made it: The entrepreneurs behind an interior design revolution had a fantastic idea: cut out the middle man
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Made of London Series
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Book tickets for Kooza now!
KOOZA is an electrifying return to the origins of Cirque du Soleil combining two circus traditions - acrobatic performance and the art of clowning.
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Topeak SmartGauge D2 $34.95
It doesn't matter how many years are under your belt; squeezing a tire is no way to determine proper inflation pressure. Topeak's SmartGauge D2, however, is the proper solution to quantifying your pressures.
The gauge features Topeak's rotating SmartHead, meaning it'll work seamlessly with both Presta and Schrader valves without changing parts. The digital gauge reads up to 250 psi, so it can be used with suspension components as well as tires. Topeak's SmartGuage D2 can also be programmed to show pressure in psi, Bar, or kg/cm2.
Tech Specs
Reviews & Community
What do you think of the
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Excellent item
Grant Kates
- Familiarity: I've used it several times
A great item to check your tire pressure on the go to help dial it in. It is very easy to use and is versatile with compatibility of both a schrader valve or presta valve.

subset: commoncrawl


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Tel: (636)529-0000
279 students
Private for-profit
Private for-profit
Get admissions information on St Louis College of Health Careers-Fenton and online degrees at CampusExplorer.com.
St. Louis College of Health Careers (SLCHC) fosters an environment of positive change and growth within itself, the community, and the greater St. Louis Metropolitan area. The College places special emphasis in assisting the unemployed or underemployed and those seeking to learn new job skills, thus moving individuals closer to full economic independence. SLCHC educates allied health professionals to meet the ever-changing needs of the health care sector. SLCHC develops and refines programs based on current health care trends. Since its founding, the College has embraced those seeking an avenue through which to improve their quality of life. Our goals at St. Louis College of Health Careers, are to Provide a supportive, flexible learning environment, Provide the opportunity for career training, Develop self-sufficient graduates, Provide ongoing outreach and guidance services that develop self-esteem and critical thinking, Assist in employment preparation and job search. St. Louis College of Health Careers has maintained a fundamental educational philosophy since its inception, and is dedicated to meeting the educational needs and professional expectations of its students. The College strives to prepare students to become competent members of the health care community. To this end, the College developed an educational structure that combines theoretical instruction with clinical experience in a specialized field, and believes this combination will best prepare students for technical careers in health care. SLCHC believes that a medical professional is best trained in a health care environment. For this reason, clinical experiences are offered within medical facilities in the St. Louis area, including hospitals, long-term care facilities, doctors' offices, and clinics. This allows clinical instruction in a modern health care environment. Qualified educators and health care professionals supervise both classroom instruction and the clinical experience.
School Highlights:
St Louis College of Health Careers-Fenton serves 279 students (100% of students are full-time).
Minority enrollment is 33% of the student body (majority Black), which is more than the state average of 20%.
St Louis College of Health Careers-Fenton is one of 14 community colleges within Saint Louis County, MO.
School Overview
The teacher population of - teachers has declined by 100% over five years.
|St Louis College of Health Careers-Fenton
|Community College Avg.
|Institution Level
|At least 2 but less than 4 years
|At least 2 but less than 4 years
|Institution Control
|Private for-profit
|Total Enrollment
279 students
|1,287 students
|# Full-Time Students
279 students
|832 students
|% American Indian/Alaskan
|% Asian
|% Hawaiian
|% Hispanic
|% Black
|% White
|% Two or more races
|Diversity ScoreThe chance that two students selected at random would be members of a different ethnic group. Scored from 0 to 1, a diversity score closer to 1 indicates a more diverse student body.
|In-State Tuition Fees
|Out-State Tuition Fees
Get admissions information on St Louis College of Health Careers-Fenton and online degrees at CampusExplorer.com.
Nearby Schools:
- College Loaction Mi. Students
Fenton Sanford-Brown College-Fenton
1345 Smizer Mill Road
Fenton , MO , 63026
(636)651-1600 1.3 Mi | 777 students
Fenton Anthem College-Fenton
645 Gravois Bluffs Blvd
Fenton , MO , 63026
(954)535-8678 3 Mi | 193 students
Kirkwood Saint Louis Community College-Meramec
11333 Big Bend Blvd
Kirkwood , MO , 63122
(314)984-7500 3.1 Mi | 11439 students
Sunset Hills Vatterott College-Sunset Hills
12900 Maurer Industrial Dr
Sunset Hills , MO , 63127
(314)843-4200 3.2 Mi | 599 students
Fenton Midwest Institute
964 South Highway Drive
Fenton , MO , 63026
(314)344-4440 5.1 Mi | 164 students
Recent Articles
Updated September 30, 2014
As careers in science, technology, engineering, and math become more prevalent, community colleges are shifting their focus to meet demand and secure their place in a rapidly changing educational landscape.
A recent study reveals that job applicants with a credential or associate's degree from a community college have slightly better chances of getting a job interview than students who attend a for-profit college or university. Since community colleges are much more budget friendly than for-profit institutions and have much better job placement results, community colleges are a much better option for employment-minded students.
Nearly 52 percent of community college students in the United States begin their freshman year in at least one remedial class. These courses, which help students acquire knowledge and skills they should have acquired in high school, do not count toward their degree requirements. As a result, students are taking longer than ever to obtain their degree, if they obtain one at all.


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Axles, CVDs, Universals & Accys
Traxxas Stub Axle Pins (4)
No. 631345$1.25
These are replacement stub axle pins for the Nitro Buggy, Nitro Street, TRX-3, Rad 2, TRX-1, Hawk 2, and Blue Eagle LS II. These pins slide through the axle and hold the wheel to the axle.Learn More
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These are the replacement rear wheel adapters for the Hawk, Hawk 2, Bullet, Sledgehammer, Eagle, and Blue Eagle LS. These are hex nuts that connect the rear wheels to the axles.Learn More
Associated Roll Pins - SC10/T2 1/16'' for 7367 (4)
No. 375369$2.25
These are the replacement universal axle roll pins for the RC10T2 truck. These pins slide through a hole drilled in the axle part of the universal and then the wheels key onto them.Learn More
Associated Dogbone Springs & Spacers (2)
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Out of stock
This is a replacement Associated Dogbone Springs & Spacers. Includes two 1/16" plastic spacers and two springs.Learn More
Traxxas Driveshaft Rubber Boots - Revo
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HP-PRT Wheel Hex 12mm - Tempest/Vertex (4)
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Out of stock
These are replacement 12mm Hex Hubs for the Hobby People Tempest 1:10 Scale 4WD Brushless Stadium Truck and the Hobby People Vertex 1:10 Scale 4WD Stadium Truck.Learn More
Associated Front Axle Crush Tube - B5, B5M
No. 556107$2.99


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I'm 14 and I haven't crushed on anyone, guys or girls. Is something wrong with me?
To keep or to share? How to know when to tell an adult a secret
Were obsessing over Jacquie Lee's Broken Ones EP
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- 16 & over
Northern Discomfort w/ Phil Hanley, Ben Kronberg, Leah Bonnema, Lenny Marcus, Josh Carter, Ray DeVito, and More!
Purchase Tickets
Show Details
- Ticket Price: $15.00
- Door Time: 7:30 PM
- Show Type: Stand Up
16 & over
Lenny Marcus has been a stand-up comedian in New York City for over a decade. He has performed at both the prestigious Just for Laughs Comedy Festival in Montreal, Canada three times and HBO's US Comedy Arts festival, in Aspen Colorado.
Lenny has performed stand-up on NBC's Friday Nite, NBC's Comedy showcase with Louie Anderson and MTV's the Jim Breuer Show. A Condom Moment, Lenny's debut as a film writer/director, has been shown at the PSNBC short film festival.
He is currently the creator/co-star of Superstar Talent, an online sitcom now in its second season. This past year Lenny wrote and co-produced a show for Comedy Central's web site called Crash Course in Comedy.
You may also have seen him in commercials for the MTV Video Movie Awards, Wendy's and Marriott or heard some of his radio characters in commercials for Southwestern Bell Telephone or Priceline.com.
Lenny has written for national publications such as UsWeekly and Life and Style magazine and is a contributing writer for DailyComedy.com. Lenny's first comedy CD, "You're Getting a Zero" will keep audiences laughing for years to come.


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Say Media is reinventing digital media and we?re looking for an experienced Product Manager to drive innovation on our market-disrupting Tempest publishing platform and our growing list of premium lifestyle brands including xoJane.com, Remodelista.com, ReadWrite.com,8/2/2014 San Francisco, CA Save This Job
Visually is the world's marketplace for visual content. The San Francisco company seamlessly connects designers, analysts, journalists, animators, and developers with brands via its cloud-based collaboration tools and operational efficiencies. This speeds time to market and7/28/2014 San Fransico, CA Save This Job
Visual.ly is a marketplace of premium designers, journalists and developers using data to tell amazing stories through infographics, videos and more. Our portfolio of clients is extremely diverse; we connect talent to brands like Dell, Morton Salt, and Causes.com. We are7/28/2014 San Francisco, CA Save This Job
Job Description Product Managers act as the internal customer and market representative for Product Development. In this capacity, Product Managers are responsible for making product functionality decisions from the beginning of requirements through the life of the product.7/13/2014 Palo Alto, CA Save This Job
Director of Business Development As a key member of our executive team, you will play an important role defining our go-to-market and distribution strategies. You will be instrumental in helping us establish customer relationships and building awareness about Expect Labs'10/6/2014 San Francisco, CA Save This Job
The Technical Project Manager leads integration efforts with customers of BloomReachâs rapidly growing enterprise web-based services. This challenging role combines the jobs of a technical engineering lead, communicator, and project manager.10/5/2014 Mountain View, CA Save This Job
Description Proofpoint, Inc. is looking for a Manufacturing Technician at its Headquarters in Sunnyvale, CA. Hours per week: approximately 40 hours / week, possible overtime at quarter end. Duties: Track inbound and outbound inventory and inventory transactions. Follow10/29/2014 Sunnyvale, CA Save This Job
Requisition ID9866BR Job TitleCommodity Manager LocationCalifornia - LitePoint - Sunnyvale HR-CA100 Employment CategoryRegular Full Time Duties & ResponsibilitiesThe Commodity Manager will focus on the development of commodity strategies and cost-down roadmaps, as well as support10/29/2014 Sunnyvale, CA Save This Job
DESCRIPTION Summary: Responsible for the investigation and closure of clinical complaints globally. Responsible for responding to clinical inquiries from physician users, patients or distributors. Essential Duties and Responsibilities include the following (other duties may be10/29/2014 Pleasanton, CA Save This Job
About us: Twilio is migrating the communications industry from its 150-year-old legacy in hardware to its future in software. With our cloud communications platform, we fundamentally change how businesses build solutions for their communications needs. Twilio has virtualized the10/28/2014 San Francisco, CA Save This Job
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ERP Implementation Pleasanton, CA, United States We continue to experience strong growth and are currently hiring Senior Retail Consultants to implement our Microsoft Dynamics AX Solutions. Candidates must have experience implementing Dynamics AX Trade & Logistics (Supply10/28/2014 Pleasanton, CA Save This Job
Position Title: Wholesale Fulfillment Analyst Reports to: Operations Director Department: Operations Direct Reports: None FLSA Status: Exempt Expectations for All Employees: Supports the organization?s mission, vision, and values by exhibiting the10/22/2014 San Francisco, CA Save This Job
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Job ID: 1459 Tax Support Temp/Clerk/Intern (Part Time) ? San Jose, CA 95131 MegaPath is one of the largest privately held, facilities-based Managed Services providers in the US. We provide industry-leading business-class Hosted Voice, Cloud Services, Internet Access, Private10/22/2014 San Jose, CA Save This Job
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Learn how to make a polystyrene cornice using a kit and a little fabric.
You can save a great deal of money and spiff up your bathroom's appearance by installing a new faucet yourself.
Space is a hard-to-come-by workshop commodity. DIY experts demonstrate how to make an inexpensive and space-saving sawhorse worktable.
Plant taller in the back and shorter in the front to provide shade and visual interest in an annual garden next to a walkway or fence.
To reduce the risk of electrical shock in the wet areas of your home, install a GFCI outlet. Use these step-by-step instructions to eas...
Learn how to prepare a home for the cold by winterizing the water heater and pressurizing the system.
Ceiling fans are heavier than typical light fixtures, so the junction box must be braced securely. Use these step-by-step instructions ...
Re-attach cabinet drawer slides by adjusting them with these simple steps.
These step-by-step instructions demonstrate how to build a simple pegboard cabinet that can greatly increase your storage area.
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Village Theatre sets intriguing drama in 'The Mousetrap'
January 22, 2013
To enjoy some of the finer things in life, there are rules. For example:
- The first rule of Fight Club is you do not talk about Fight Club.
- What happens in Vegas, stays in Vegas.
- And, do not reveal the plot of "The Mousetrap."
Each has its own reason to remain spoiler free. Village Theatre hopes its patrons adhere to the latter so subsequent audiences can enjoy its latest production, Agatha Christie's "The Mousetrap."
What started as an 80th birthday tribute written for Queen Elizabeth in 1947, Agatha Christie thought her radio broadcast, "Three Blind Mice," adapted for stage would have an uneventful eight-month run, tops.
Village Theatre is set to spring 'The Mousetrap'
January 8, 2013
Expect more than a month of snow — on the Village Theatre stage, at least — as the scene-setting snowstorm in "The Mousetrap" is re-created night after night.
The classic whodunit is considered mystery maven Agatha Christie's masterpiece. "The Mousetrap" opens Jan. 16 as the lone play — the only nonmusical offering in the 2012-13 lineup — in the Village Theatre season.
Musical about surviving high school is as easy as 'Rocket Science'
January 1, 2013
Hal Hefner is accustomed to high school's indignities and perils.
Besides a tumultuous home life, high school presents a treacherous gauntlet for Hal, a stutterer. The clumsy attempts at romance, friendship and, importantly, earning a spot on the debate team form the plot for "Rocket Science" — a musical created for youth performers and set to open at Village Theatre's First Stage Theatre on Jan. 5.
The decision to present "Rocket Science" — a musical fostered on the Village Theatre stage in the Festival of New Musicals — is not rocket science, cast members and the director said.
The piece is written specifically for teenagers. "Rocket Science" marks the first time KIDSTAGE performers presented a musical from the festival. The show also marks the debut for the "Rocket Science" musical.
Issaquah memorable moments from 2012 entertain, educate
December 25, 2012
Entertainment came to Issaquah in some surprising forms throughout 2012.
Besides the usual retinue on the page, stage and screen, a documentary peeled back the layers at Costco and big-name authors signed books for local readers.
The city hosted celebrities, spotlighted residents on the national stage and celebrated big debuts in recent months. The boldface names earned cred through stints on reality TV, titles on bestseller lists and hardware aplenty — a Tony Award, a National Book Award.
Reality TV plugs in local contestants
Lindzi Cox pursued "The Bachelor" and Lizzie Parker competed for the title "Fashion Star" as local women added grace to reality TV contests.
Cox, a 2003 Liberty High School grad, competed against 24 other bachelorettes to win a rose from the titular bachelor, Ben Flajnik, and reached the final round on the ABC dating game.
Skyline High School alumna tackles role in 'Celebrity Ghost Stories'
December 4, 2012
For years, actress Dot Jones — feared Coach Shannon Beiste on the musical sitcom "Glee" — felt a supernatural presence, not a menacing ghost, but a spirit that watched over her.
Jones' tale comes to the screen Dec. 8 in the BIO Channel series "Celebrity Ghost Stories" — a chronicle of celebrities' paranormal experiences. Heather Refvem, a Skyline High School and Village Theatre alumna, portrays a young Jones in flashback sequences during the episode.
The episode marks the television debut for Refvem, a stage veteran since starring in local theater productions as a child.
Sammamish Symphony joins choir to create sounds of season
December 4, 2012
One of Sammamish's holiday traditions, the Holiday Pops concert by the Sammamish Symphony, will have a new twist this year.
John Patrick Lowrie, known for work at the Village Theatre and voice-acting in a host of popular video games, will read "'Twas the Night Before Christmas," to the accompaniment of the symphony.
"We try to make it interesting," said R. Joseph Scott, conductor of the symphony.
The show will feature a host of popular holiday songs, Scott said, including Christmas and Hanukkah songs.
'Fiddler on the Roof' delivers perfect match of familiar, fresh
November 13, 2012
"Fiddler on the Roof" is rooted in a bleak era and setting — circa 1905 czarist Russia, a bastion of anti-Semitic sentiment — and the plot only turns grimmer as the acts progress.
The musical bears a reputation as a downer and, on the surface, "Fiddler on the Roof" seems like a strange choice for Village Theatre's holiday offering.
But "Fiddler on the Roof" also shares essential truths about family and, as lead character Tevye is fond to point out, tradition — important tenets in a season often focused on everything but.
Scribes Joseph Stein and Jeffrey Bock ladled on Borscht Belt humor to introduce audiences to the population of Anatevka, a shtetl, or village. The numbers "Matchmaker" and "If I Were a Rich Man" deserve entries in the Great American Songbook.
Village Theatre's 'Fiddler on the Roof' stars dynamic duo
October 30, 2012
The lead actors in Village Theatre's soon-to-open "Fiddler on Roof" share the same easy rhythms as a long-married couple — a comfortable arrangement, because Eric Polani Jensen and Bobbi Kotula play a long-married couple in the classic musical.
The professional relationship between Jensen and Kotula extends back to the early 1990s, and the duo is poised to share the stage again Nov. 7 as "Fiddler on the Roof" opens. In the musical, Jensen is Tevye, a Jewish milkman struggling to stick to tradition in czarist Russia, and Kotula is Tevye's sharp-tongued but soft-hearted wife.
The duo often shares a stage at Village Theatre and other local playhouses. The familiarity comes across as Jensen and Kotula discussed the theme at the show's core. In the opening number and throughout the musical, "Fiddler on the Roof" focuses on the tug-of-war between tradition and change.
Village Theatre's KIDSTAGE hosts Sing It Forward fundraiser
October 16, 2012
Performers in Village Theatre's KIDSTAGE program plan to sing to raise money for the youth education effort.
Sing It Forward includes a benefit concert from young performers in the KIDSTAGE and Village Theatre Institute programs. The program includes a benefit concert at 7 p.m. Oct. 20 and a pizza party at 6 p.m. Oct. 21.
The benefit concert is meant for patrons 21 and older; the pizza party is more casual and open to all ages. Both events take place at Village Theatre's First Stage Theatre, 120 Front St. N.
Tickets for the benefit concert cost $100. Tickets for the pizza party cost $40 for general admission and $20 for youth admission. Learn more at www.villagetheatre.org/SIF-Issaquah.php.
'Que Será!' musical honors Doris Day's iconic career
October 9, 2012
Iconic American songstress Doris Day may have left showbiz for good in the 1970s, but that doesn't mean enthusiasm has soured for the performer who starred in classic films such as "Teacher's Pet" and "The Man Who Knew Too Much."
"Que Será! Celebrating Doris Day," a musical coming to Village Theatre's First Stage Theatre on Oct. 14, pays tribute to the legendary singer.
Vocalist Kristi King dons a familiar platinum-blonde wig and sings more than 20 of Day's greatest hits in the show. King also tells stories of Day's life, in the actual persona of the beloved entertainer.
"It's really a walk down memory lane of one of the most amazing performers ever," King said.
Accompanied by the Hans Brehmer Quartet, King will sing some of Day's most popular songs, including, of course, "Que Será, Será." She will also re-enact a scene from "Pillow Talk," the award-winning romantic comedy starring Day and Rock Hudson.
King has always been a fan of Day, ever since her mother, also a singer, played Day's records in their Portland home.


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Recent Research Articles from UNTHSC
Involvement of AP-1 and C/EBPβ in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma.
Involvement of AP-1 and C/EBPβ in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma.
PLoS One. 2013;8(11):e79183
Authors: He S, Minton AZ, Ma HY, Stankowska DL, Sun X, Krishnamoorthy RR
Previous studies showed that the endothelin B receptor (ETB) expression was upregulated and played a key role in neurodegeneration in rodent models of glaucoma. However, the mechanisms underlying upregulation of ETB receptor expression remain largely unknown. Using promoter-reporter assays, the 1258 bp upstream the human ETB promoter region was found to be essential for constitutive expression of ETB receptor gene in human non-pigmented ciliary epithelial cells (HNPE). The -300 to -1 bp and -1258 to -600 bp upstream promoter regions of the ETB receptor appeared to be the key binding regions for transcription factors. In addition, the crucial AP-1 binding site located at -615 to -624 bp upstream promoter was confirmed by luciferase assays and CHIP assays which were performed following overexpression of c-Jun in HNPE cells. Overexpression of either c-Jun or C/EBPβ enhanced the ETB receptor promoter activity, which was reflected in increased mRNA and protein levels of ETB receptor. Furthermore, knock-down of either c-Jun or C/EBPβ in HNPE cells was significantly correlated to decreased mRNA levels of both ETB and ETA receptor. These observations suggest that c-Jun and C/EBPβ are important for regulated expression of the ETB receptor in HNPE cells. In separate experiments, intraocular pressure (IOP) was elevated in one eye of Brown Norway rats while the corresponding contralateral eye served as control. Two weeks of IOP elevation produced increased expression of c-Jun and C/EBPβ in the retinal ganglion cell (RGC) layer from IOP-elevated eyes. The mRNA levels of c-Jun, ETA and ETB receptor were upregulated by 2.2-, 3.1- and 4.4-fold in RGC layers obtained by laser capture microdissection from retinas of eyes with elevated IOP, compared to those from contralateral eyes. Taken together, these data suggest that transcription factor AP-1 plays a key role in elevation of ETB receptor in a rodent model of ocular hypertension.
PMID: 24265756 [PubMed - indexed for MEDLINE]
Bilorrhea Secondary to Bronchobiliary Fistula.
Bilorrhea Secondary to Bronchobiliary Fistula.
Int Surg. 2014 July-August;99(4):438-441
Authors: Olivencia-Yurvati AH, Rollins C
Abstract Bronchobiliary fistula (BBF) is a rare condition which occurs most commonly as a complication of hydatid cyst liver disease. The following report describes a patient who presented with biliptysis 6 months following decortication of an empyema that had occurred following partial hepatectomy of a colon cancer metastasis. This is the only case to our knowledge that describes the presentation of a BBF in this context. The patient was diagnosed with BBF and successfully underwent open thoracotomy for fistulectomy and repair.
PMID: 25058780 [PubMed - as supplied by publisher]
Two-week Normobaric Intermittent-Hypoxia Exposures Enhance Oxyhemoglobin Equilibrium and Cardiac Responses during Hypoxemia.
Two-week Normobaric Intermittent-Hypoxia Exposures Enhance Oxyhemoglobin Equilibrium and Cardiac Responses during Hypoxemia.
Am J Physiol Regul Integr Comp Physiol. 2014 Jul 23;
Authors: Zhang P, Downey HF, Chen S, Shi X
Intermittent-hypoxia (IH) is extensively applied to challenge cardiovascular and respiratory function, and to induce physiological acclimatization. The purpose of this study was to test the hypothesis that oxyhemoglobin equilibrium and tachycardiac responses during hypoxemia were enhanced after 14-day IH exposures. Normobaric-poikilocapnic hypoxia was induced with inhalation of 10% O2 for 5-6 min interspersed with 4-min recovery on eight non-smokers. Heart rate (HR), arterial O2 saturation (SaO2) and end-tidal O2 (PETO2) were continuously monitored during cyclic normoxia and hypoxia. These variables were compared during the 1st and 5th hypoxic bouts between Day 1 and Day 14. There was a rightward shift in the oxyhemoglobin equilibrium response following 14-day IH exposures, as indicated by the greater PETO2 (an index of arterial PO2) at 50% of SaO2 (P50) on Day 14 compared to Day 1: 33.9±1.5 vs 28.2±1.3 mmHg (P =0.005) during the 1st hypoxic bout and 39.4±2.4 vs 31.4±1.5 mmHg (P =0.006) during the 5th hypoxic bout; and by the augmented gains of ∆SaO2/∆PETO2 (i.e., de-oxygenation) during PETO2 from 65 to 40 mmHg in the 1st (1.12±0.08 vs 0.80±0.02 %/mmHg, P =0.001) and the 5th (1.76±0.31 vs 1.05±0.06 %/mmHg, P =0.024) hypoxic bouts. Repetitive IH exposures attenuated (P =0.049) the tachycardiac response to hypoxia while significantly enhanced normoxic R-R interval variability in low-frequency and high-frequency spectra without changes in arterial blood pressure at rest or during hypoxia. We conclude that 14-day IH exposures enhance arterial O2 delivery and improve vagal control of HR during hypoxic hypoxemia.
PMID: 25056104 [PubMed - as supplied by publisher]
Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.
Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.
Adv Exp Med Biol. 2014;801:455-62
Authors: Choudhury S, Nashine S, Bhootada Y, Kunte MM, Gorbatyuk O, Lewin AS, Gorbatyuk M
The goal of this study is to validate whether reprogramming of the UPR via modulation of pro-apoptotic caspase-7 and CHOP proteins could be an effective approach to slow down the rate of retinal degeneration in ADRP mice. In order to pursue our goal we created the T17M RHO CASP7 and T17M RHO CHOP mice to study the impact of the CASP7 or CHOP ablations in T17M RHO retina by ERG, SD-OCT, histology and western blot analysis. The scotopic ERG demonstrated that the ablation of the CASP7 in T17M RHO retina leads to significant preservation of the function of photoreceptors compared to control. Surprisingly, the ablation of pro-apoptotic CHOP protein in T17M RHO mice led to a more severe form of retinal degeneration. Results of the SD-OCT and histology were in agreement with the ERG data. The further analysis demonstrated that the preservation of the structure and function or the acceleration of the onset of the T17M RHO photoreceptor degeneration occurred via reprogramming of the UPR. In addition, the CASP7 ablation leads to the inhibition of cJUN mediated apoptosis, while the ablation of CHOP induces an increase in the HDAC. Thus, manipulation with the UPR requires careful examination in order to achieve a therapeutic effect.
PMID: 24664731 [PubMed - indexed for MEDLINE]
Reduction of stutter ratios in short tandem repeat loci typing of low copy number DNA samples.
Reduction of stutter ratios in short tandem repeat loci typing of low copy number DNA samples.
Forensic Sci Int Genet. 2014 Jan;8(1):213-8
Authors: Seo SB, Ge J, King JL, Budowle B
Increased height of stutter peaks is a phenomenon with low copy number (LCN) short tandem repeat (STR) typing that can impact interpretation. An alternative strategy of lowering the annealing/extension temperature (LT) at 56 °C was designed to attempt to decrease the heights of stutter peaks. STR typing results were generated in terms of stutter ratios using LT-PCR conditions and compared with data obtained using standard (STD) PCR conditions. DNA samples ranging from 100 to 25 pg were amplified using reagents contained in the AmpFℓSTR Identifiler PCR Amplification or AmpFℓSTR Identifiler Plus PCR Amplification kits with 32 or 34 PCR cycles. Stutter ratios decreased by an average of 14.7%, 14.9% and 18.1% at 100, 50 and 25 pg of template DNA under LT conditions compared with those of STD conditions in the Identifiler Kit amplified samples. The LT conditions also decreased average stutter ratios by 13.3% compared with those of STD conditions in the Identifiler Plus Kit amplified samples. The overall PCR efficiency obtained with STD and LT conditions with the two STR kits was comparable in terms of the number of detected alleles, peak heights and peak height ratios. These results support the hypothesis that a lower temperature annealing/extension step reduces the likelihood of slippage during PCR by enhancing the stability of the DNA polymerase/template DNA complex or the stability of the generated duplex than the conditions of the standard extension step. This stability in turn would result in lower stutter ratios.
PMID: 24315611 [PubMed - indexed for MEDLINE]
Low serum zinc is associated with elevated risk of cadmium nephrotoxicity.
Low serum zinc is associated with elevated risk of cadmium nephrotoxicity.
Environ Res. 2014 Jul 17;134C:33-38
Authors: Lin YS, Ho WC, Caffrey JL, Sonawane B
BACKGROUND: Despite animal evidence suggests that zinc modulates cadmium nephrotoxicity, limited human data are available.
OBJECTIVE: To test the hypothesis that low serum zinc concentrations may increase the risk of cadmium-mediated renal dysfunction in humans.
METHODS: Data from 1545 subjects aged 20 or older in the National Health and Nutrition Examination Survey (NHANES), 2011-2012 were analyzed. Renal function was defined as impaired when estimated glomerular filtration rate (eGFR) fell below 60ml/min/1.73m(2) and/or the urinary albumin-to-creatinine ratio surpassed 2.5 in men and 3.5mg/mmol in women.
RESULTS: Within the study cohort, 117 subjects had reduced eGFR and 214 had elevated urinary albumin. After adjusting for potential confounders, subjects with elevated blood cadmium (>0.53μg/L) were more likely to have a reduced eGFR (odds ratio [OR]=2.21, 95% confidence interval [CI]: 1.09-4.50) and a higher urinary albumin (OR=2.04, 95% CI: 1.13-3.69) than their low cadmium (<0.18μg/L) peers. In addition, for any given cadmium exposure, low serum zinc is associated with elevated risk of reduced eGFR (OR=3.38, 95% CI: 1.39-8.28). A similar increase in the odds ratio was observed between declining serum zinc and albuminuria but failed to reach statistical significance. Those with lower serum zinc/blood cadmium ratios were likewise at a greater risk of renal dysfunction (p<0.01).
CONCLUSIONS: This study results suggest that low serum zinc concentrations are associated with an increased risk of cadmium nephrotoxicity. Elevated cadmium exposure is global public health issue and the assessment of zinc nutritional status may be an important covariate in determining its effective renal toxicity.
PMID: 25042034 [PubMed - as supplied by publisher]
Characterization of [(3) H]LS-3-134, a Novel Arylamide Phenylpiperazine D3 Dopamine Receptor Selective Radioligand.
Characterization of [(3) H]LS-3-134, a Novel Arylamide Phenylpiperazine D3 Dopamine Receptor Selective Radioligand.
J Neurochem. 2014 Jul 18;
Authors: Rangel-Barajas C, Malik M, Taylor M, Neve KA, Mach RH, Luedtke RR
LS-3-134 is a substituted N-phenylpiperazine derivative that has been reported to exhibit a) high-affinity binding (Ki value 0.2 nM) at human D3 dopamine receptors, b) >100-fold D3 vs. D2 dopamine receptor subtype binding selectivity and c) low-affinity binding (Ki values >5,000 nM) at sigma 1 and sigma 2 receptors. Based upon a forskolin-dependent activation of the adenylyl cyclase inhibition assay, LS-3-134 is a weak partial agonist at both D2 and D3 dopamine receptor subtypes (29% and 35% of full agonist activity, respectively). In this study, [(3) H]-labeled LS-3-134 was prepared and evaluated to further characterize its use as a D3 dopamine receptor selective radioligand. Kinetic and equilibrium radioligand binding studies were performed. This radioligand rapidly reaches equilibrium (10-15 min at 37°C) and binds with high affinity to both human (Kd = 0.06 ± 0.01 nM) and rat (Kd = 0.2 ± 0.02 nM) D3 receptors expressed in HEK-293 cells. Direct and competitive radioligand binding studies using rat caudate and nucleus accumbens tissue indicate that [(3) H]LS-3-134 selectively binds a homogeneous population of binding sites with a dopamine D3 receptor pharmacological profile. Based upon these studies we propose that [(3) H]LS-3-134 represents a novel D3 dopamine receptor selective radioligand that can be used for studying the expression and regulation of the D3 dopamine receptor subtype. This article is protected by copyright. All rights reserved.
PMID: 25041389 [PubMed - as supplied by publisher]
Lenticular mitoprotection. Part B: GSK-3β and regulation of mitochondrial permeability transition for lens epithelial cells in atmospheric oxygen.
Lenticular mitoprotection. Part B: GSK-3β and regulation of mitochondrial permeability transition for lens epithelial cells in atmospheric oxygen.
Mol Vis. 2013;19:2451-67
Authors: Brooks MM, Neelam S, Cammarata PR
PURPOSE: Loss of integrity of either the inner or outer mitochondrial membrane results in the dissipation of the mitochondrial electrochemical gradient that leads to mitochondrial membrane permeability transition (mMPT). This study emphasizes the role of glycogen synthase kinase 3beta (GSK-3β) in maintaining mitochondrial membrane potential, thus preventing mitochondrial depolarization (hereafter termed mitoprotection). Using 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), an inhibitor of GSK-3β, and drawing a distinction between it and 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene (UO126), an inhibitor of extracellular-signal-regulated kinase (ERK) phosphorylation, the means by which GSK-3β influences mitoprotection in cultured human lens epithelial (HLE-B3) cells and normal, secondary cultures of bovine lens epithelial cells, maintained in atmospheric oxygen, was investigated.
METHODS: Virally transfected human lens epithelial cells (HLE-B3) and normal cultures of bovine lens epithelial cells were exposed to acute hypoxic conditions (about 1% O2) followed by exposure to atmospheric oxygen (about 21% O2). Specific antisera and western blot analysis was used to examine the state of phosphorylation of ERK and GSK-3β, as well as the phosphorylation of a downstream substrate of GSK-3β, glycogen synthase (GS, useful in monitoring GSK-3β activity). The potentiometric dye, 1H-benzimidazolium-5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propenyl]-1,3-diethyl-iodide (JC-1), was used to monitor mitochondrial depolarization upon exposure of inhibitor treatment relative to the control cells (mock inhibition) in atmospheric oxygen. Caspase-3 activation was scrutinized to determine whether mitochondrial depolarization inevitably leads to apoptosis.
RESULTS: Treatment of HLE-B3 cells with SB216763 (12 µM) inactivated GSK-3β activity as verified by the enzyme's inability to phosphorylate its substrate, GS. SB216763-treated cells were not depolarized relative to the control cells as demonstrated with JC-1 fluorescent dye analysis. The HLE-B3 cells treated with UO126, which similarly blocked phosphorylation of GS, were nevertheless prone to mMPT relative to the control cells. Western blot analysis determined that Bcl-2-associated X (BAX) levels were unchanged for SB216763-treated or UO126-treated HLE-B3 cells when compared to their respective control cells. However, unlike the SB216763-treated cells, the UO126-treated cells showed a marked absence of Bcl-2, as well as phosphorylated Bcl-2 relative to the controls. UO126 treatment of bovine lens epithelial cells showed similar results with pBcl-2 levels, while the Bcl-2 content appeared unchanged relative to the control cells. HLE-B3 and normal bovine lens cell cultures showed susceptibility to mMPT associated with the loss of pBcl-2 by UO126 treatment.
CONCLUSIONS: MITOCHONDRIAL DEPOLARIZATION MAY OCCUR BY ONE OF TWO KEY OCCURRENCES: interruption of the electrochemical gradient across the inner mitochondrial membrane resulting in mMPT or by disruption of the integrity of the inner or outer mitochondrial membrane. The latter scenario is generally tightly regulated by members of the Bcl-2 family of proteins. Inhibition of GSK-3β activity by SB216763 blocks mMPT by preventing the opening of the mitochondrial permeability transition pore. UO126, likewise, inhibits GSK-3β activity, but unlike SB216763, inhibition of ERK phosphorylation induces the loss of intracellular pBcl-2 levels under conditions where intracellular BAX levels remain constant. These results suggest that the lenticular mitoprotection normally afforded by the inactivation of GSK-3β activity may, however, be bypassed by a loss of pBcl-2, an anti-apoptotic member of the Bcl-2 family. Bcl-2 prevents the translocation of BAX to the mitochondrial outer membrane inhibiting depolarization by disrupting the normal electrochemical gradient leading to mMPT.
PMID: 24319338 [PubMed - indexed for MEDLINE]
Single nucleotide polymorphism typing with massively parallel sequencing for human identification.
Single nucleotide polymorphism typing with massively parallel sequencing for human identification.
Int J Legal Med. 2013 Nov;127(6):1079-86
Authors: Seo SB, King JL, Warshauer DH, Davis CP, Ge J, Budowle B
The Ion AmpliSeq™ HID single nucleotide polymorphism (SNP) panel, a primer pool of 103 autosomal SNPs and 33 Y-SNPs, was evaluated using the Ion 314™ Chip on the Ion PGM™ Sequencer with four DNA samples. The study focused on the sequencing of DNA at three different initial target quantities, related interpretation issues, and concordance of results with another sequencing platform, i.e., Genome Analyzer IIx. With 10 ng of template DNA, all genotypes at the 136 SNPs were detected. With 1 ng of DNA, all SNPs were detected and one SNP locus in one sample showed extreme heterozygote imbalance on allele coverage. With 100 pg of DNA, an average of 1.6 SNP loci were not detected, and an average of 4.3 SNPs showed heterozygote imbalance. The average sequence coverage was 945-600× at autosomal SNPs and 465-209× at Y-SNPs for 10 ng-100 pg of DNA. The average heterozygote allele coverage ratio was 89.6-61.8 % for 10 ng-100 pg of DNA. At 10 ng of DNA, all genotypes of the 95 SNPs shared between the two different sequencing platforms were concordant except for one SNP, rs1029047. The error was due to the misalignment of a flanking homopolymer. Overall, the data support that genotyping a large battery of SNPs is feasible with massively parallel sequencing. With barcode systems, better allele balance, and specifically designed alignment software, a more comprehensive rapid genotyping and more cost-effective results may be obtained from multiple samples in one analysis than are possible with current typing and capillary electrophoresis systems.
PMID: 23736940 [PubMed - indexed for MEDLINE]
5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade.
5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade.
J Pharmacol Exp Ther. 2014 May;349(2):288-96
Authors: Hosford PS, Mifflin SW, Ramage AG
The effect of blockade of either 5-hydroxytryptamine (5-HT)/serotonin transporter (SERT) with citalopram or the organic cation transporter 3 (OCT3)/plasma membrane monoamine transporter (PMAT) with decynium-22 (D-22) on spontaneous and evoked release of 5-HT in the nucleus tractus solitarius (NTS) was investigated in rat brainstem slices treated with gabazine. 5-HT release was measured indirectly by changes in the frequency and amplitude of glutamatergic miniature excitatory postsynaptic currents (mEPSCs) [in the presence of tetrodotoxin (TTX)] and evoked EPSCs. Blockade of 5-HT3 receptors with granisetron reduced, whereas the 5-HT3 agonist phenylbiguanide increased, the frequency of mEPSCs. 5-HT decreased mEPSC frequency at low concentrations and increased frequency at high concentrations. This inhibition was blocked by the 5-HT1A antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide (WAY-100635), which was ineffective on its own, whereas the excitation was reversed by granisetron. The addition of citalopram or D-22 caused inhibition, which was prevented by 5-HT1A blockade. Thus, in the NTS, the spontaneous release of 5-HT is able to activate 5-HT3 receptors, but not 5-HT1A receptors, as the release in their vicinity is removed by uptake. The ineffectiveness of corticosterone suggests that the low-affinity, high-capacity transporter is PMAT, not OCT3. For evoked 5-HT release, only D-22 caused an increase in the amplitude of EPSCs, with a decrease in the paired pulse ratio, and increased the number of spontaneous EPSCs after 20-Hz stimulation. Thus, for the evoked release of 5-HT, the low-affinity, high-capacity transporter PMAT, but not 5-HT transporter (5-HTT)/SERT, is important in the regulation of changes in 5-HT extracellular concentration.
PMID: 24618127 [PubMed - indexed for MEDLINE]
Establishment of human retinal microvascular endothelial cells with extended life-span.
Establishment of human retinal microvascular endothelial cells with extended life-span.
In Vivo. 2013 Nov-Dec;27(6):685-94
Authors: Kashyap MV, Ranjan AP, Shankardas J, Vishwanatha JK
AIM: To generate and characterize a telomerase-immortalized human retinal microvascular endothelial cell (HREC) line. This cell line may be utilized as an in vitro model to study the molecular basis of several diseases of the human retina.
MATERIALS AND METHODS: Primary retinal neuronal cells were isolated and transfected with plasmid encoding full-length human telomerase reverse transcriptase (hTERT). Transfected cells were selected and characterized to determine telomerase activity, karyotype, proliferative capacity and functionality.
RESULTS: HREC-hTERT cells appear morphologically similar to primary endothelial cells and have an extended in vitro life-span. HREC-hTERT cells express the progenitor/stem cell marker nestin. They have active telomerase and a high proliferative capacity. These cells also maintain a diploid karyotype. The HREC-hTERT cells showed high colony-formation capacity and plating efficiency compared to the primary cells. These cells are capable of differentiation into neuronal and glial cell phenotypes and the differentiated cells express the astrocyte marker glial fibrillary acidic protein (GFAP) and the neuronal marker microtubule-associated protein-2 (MAP2), respectively.
CONCLUSION: The in vitro life-span of human retinal neuronal endothelial cells can be extended by ectopic expression of hTERT without altering the genetic stability and functionality of these cells. These cells will be a valuable tool to further our understanding on the role of HRECs in the human blood-retinal-barrier and in angiogenesis and neovascularization.
PMID: 24292569 [PubMed - indexed for MEDLINE]
Treatment of Acute Pulmonary Embolism: Update on Newer Pharmacologic and Interventional Strategies.
Treatment of Acute Pulmonary Embolism: Update on Newer Pharmacologic and Interventional Strategies.
Biomed Res Int. 2014;2014:410341
Authors: Pelliccia F, Schiariti M, Terzano C, Keylani AM, D'Agostino DC, Speziale G, Greco C, Gaudio C
Acute pulmonary embolism (PE) is a common complication in hospitalized patients, spanning multiple patient populations and crossing various therapeutic disciplines. Current treatment paradigm in patients with massive PE mandates prompt risk stratification with aggressive therapeutic strategies. With the advent of endovascular technologies, various catheter-based thrombectomy and thrombolytic devices are available to treat patients with massive or submassive PE. In this paper, a variety of newer treatment strategies for PE are analyzed, with special emphasis on various interventional treatment strategies. Clinical evidence for utilizing endovascular treatment modalities, based on our institutional experience as well as a literature review, is provided.
PMID: 25025049 [PubMed - as supplied by publisher]
Validation of a Serum Screen for Alzheimer's Disease Across Assay Platforms, Species, and Tissues.
Validation of a Serum Screen for Alzheimer's Disease Across Assay Platforms, Species, and Tissues.
J Alzheimers Dis. 2014 Jul 11;
Authors: O'Bryant SE, Xiao G, Zhang F, Edwards M, German DC, Yin X, Como T, Reisch J, Huebinger RM, Graff-Radford N, Dickson D, Barber R, Hall J, O'Suilleabhain P, Grammas P
Background: There is a significant need for rapid and cost-effective biomarkers of Alzheimer's disease (AD) for advancement of clinical practice and therapeutic trials. Objective: The aim of the current study was to cross-validate our previously published serum-based algorithm on an independent assay platform as well as validate across tissues and species. Preliminary analyses were conducted to examine the utility in distinguishing AD from non-AD neurological disease (Parkinson's disease, PD). Methods: Serum proteins from our previously published algorithm were quantified from 150 AD cases and 150 controls on the Meso Scale Discovery (MSD) platform. Serum samples were analyzed from 49 PD cases and compared to a random sample of 51 AD cases and 62 controls. Support vector machines (SVM) were used to discriminate PD versus AD versus controls. Human and AD mouse model microvessel images were quantified with HAMAMATSU imaging software. Mouse serum biomarkers were assayed via MSD. Results: Analysis of 21 serum proteins from 150 AD cases and 150 controls yielded an algorithm with sensitivity and specificity of 0.90 for correctly classifying AD. This multi-marker approach was then validated across species and tissue. Assay of the top proteins in human and AD mouse model brain microvessels correctly classified 90-100% of the samples. SVM analyses were highly accurate at distinguishing PD versus AD versus controls. Conclusions: This serum-based biomarker panel should be tested in a community-based setting to determine its utility as a first-line screen for AD and non-AD neurological diseases for primary care providers.
PMID: 25024345 [PubMed - as supplied by publisher]
In vivo Assessment of SMT19969 in the Hamster Model of Clostridium difficile Infection.
In vivo Assessment of SMT19969 in the Hamster Model of Clostridium difficile Infection.
Antimicrob Agents Chemother. 2014 Jul 14;
Authors: Weiss W, Pulse M, Vickers R
SMT19969 (2, 2' bis(4-pyridyl)3H, 3' H 5,5 bibenzimidazole) is a novel, narrow spectrum, non-absorbable antibiotic currently in development for the treatment of Clostridium difficile infection. The comparative activity of SMT19969 and vancomycin against non-epidemic and epidemic strains of C. difficile was studied in an established hamster model. Against non-epidemic (VA11) strains, survival ranged from 80% to 95% in SMT19969 treated animals. Vancomycin exhibited 100% protection during treatment with relapse observed starting on Day 9 and 50% survival at Day 20. At 50 mg/kg, SMT19969 administered orally, qd x 5 days exhibited full protection of treated animals on dosing days and out through day 12 against epidemic strains. Vancomycin also protected during the dosing interval, but apparent relapse occurred earlier starting on day 11. SMT19969 exhibited excellent in vitro activity with an MIC of 0.25 ug/mL for all isolates. MICs for vancomycin were 2-4 fold higher at ≤0.5-1 ug/mL. All plasma samples of SMT19969 were below the limit of quantitation (25 ng/mL) at all time points, consistent with the reported lack of bioavailability of the compound. Cecal concentrations were significantly above MIC (ranging from 96μg/mL to 172μg/mL).
PMID: 25022586 [PubMed - as supplied by publisher]
Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress.
Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress.
J Diabetes Res. 2014;2014:137919
Authors: Yan LJ
Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not intervened, will eventually be followed by appearance of frank diabetes. The mechanisms of this chronic pathogenic process are complex but have been suggested to involve production of reactive oxygen species (ROS) and oxidative stress. In this review, I highlight evidence that reductive stress imposed by overflux of NADH through the mitochondrial electron transport chain is the source of oxidative stress, which is based on establishments that more NADH recycling by mitochondrial complex I leads to more electron leakage and thus more ROS production. The elevated levels of both NADH and ROS can inhibit and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH), respectively, resulting in blockage of the glycolytic pathway and accumulation of glycerol 3-phospate and its prior metabolites along the pathway. This accumulation then initiates all those alternative glucose metabolic pathways such as the polyol pathway and the advanced glycation pathways that otherwise are minor and insignificant under euglycemic conditions. Importantly, all these alternative pathways lead to ROS production, thus aggravating cellular oxidative stress. Therefore, reductive stress followed by oxidative stress comprises a major mechanism of hyperglycemia-induced metabolic syndrome.
PMID: 25019091 [PubMed - as supplied by publisher]
Manual therapy, exercise, and education for low back pain and pelvic pain during pregnancy.
Manual therapy, exercise, and education for low back pain and pelvic pain during pregnancy.
Am J Obstet Gynecol. 2014 Jun;210(6):592-3
Authors: Licciardone JC, Aryal S
PMID: 24607754 [PubMed - indexed for MEDLINE]
Acute improvement in hemodynamic control after osteopathic manipulative treatment in the third trimester of pregnancy.
Acute improvement in hemodynamic control after osteopathic manipulative treatment in the third trimester of pregnancy.
Complement Ther Med. 2013 Dec;21(6):618-26
Authors: Hensel KL, Pacchia CF, Smith ML
OBJECTIVES: The physiological changes that occur during pregnancy, including increased blood volume and cardiac output, can affect hemodynamic control, most profoundly with positional changes that affect venous return to the heart. By using Osteopathic Manipulative Treatment (OMT), a body-based modality theorized to affect somatic structures related to nervous and circulatory systems, we hypothesized that OMT acutely improves both autonomic and hemodynamic control during head-up tilt and heel raise in women at 30 weeks gestation.
DESIGN: One hundred subjects were recruited at 30 weeks gestation.
SETTING: The obstetric clinics of UNTHealth in Fort Worth, TX.
INTERVENTION: Subjects were randomized into one of three treatment groups: OMT, placebo ultrasound, or time control. Ninety subjects had complete data (N=25, 31 and 34 in each group respectively).
MAIN OUTCOME MEASURES: Blood pressure and heart rate were recorded during 5 min of head-up tilt followed by 4 min of intermittent heel raising.
RESULTS: No significant differences in blood pressure, heart rate or heart rate variability were observed between groups with tilt before or after treatment (p>0.36), and heart rate variability was not different between treatment groups (p>0.55). However, blood pressure increased significantly (p=0.02) and heart rate decreased (p<0.01) during heel raise after OMT compared to placebo or time control.
CONCLUSIONS: These data suggest that OMT can acutely improve hemodynamic control during engagement of the skeletal muscle pump and this was most likely due to improvement of structural restrictions to venous return.
PMID: 24280470 [PubMed - indexed for MEDLINE]
Evaluation of a novel material, Diomics X-Swab™, for collection of DNA.
Evaluation of a novel material, Diomics X-Swab™, for collection of DNA.
Forensic Sci Int Genet. 2014 Jun 24;12C:192-198
Authors: Marshall PL, Stoljarova M, Larue BL, King JL, Budowle B
Success of DNA typing is related to the amount of target material recovered from an evidentiary item. Generally, the more DNA that is recovered, the better the chance is of obtaining a typing result that will be robust and reliable. One method of collecting stain materials is by swabbing. Recovery of DNA from a number of commercially available swabs is not an efficient process. The X-Swab™ (Diomics Corporation, La Jolla, CA) is a unique bio-specimen collection material with highly absorptive properties and can be dissolved during certain extraction conditions. Therefore, more DNA may be collected from a substrate and be released from the swab matrix than other swabs. The ability to recover DNA from X-Swab material and success in STR typing were compared with the Copan 4N6FLOQSwab™ (Brescia, Italy), a device which utilizes a proprietary flocked-swab technology to maximize DNA collection and elution efficiency. Both types of swabs were impregnated with known amounts of DNA and body fluids and allowed to air dry. In addition, blood was placed onto glass slides, allowed to dry and collected using both types of swabs. DNA recovery was assessed by DNA quantitation and by STR typing. Results suggested that X-Swab material yielded greater DNA recovery, particularly of low quantity samples (defined as diluted neat samples), compared with the 4N6FLOQSwab. Results also indicated that X-Swab material itself enhances yield of PCR products.
PMID: 25016249 [PubMed - as supplied by publisher]
ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.
ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.
Age (Dordr). 2014 Aug;36(4):9685
Authors: Su C, Sun F, Cunningham RL, Rybalchenko N, Singh M
Oxidative stress has long been implicated in the pathogenesis of various neurodegenerative disorders such as Alzheimer's disease and stroke. While high levels of oxidative stress are generally associated with cell death, a slight rise of reactive oxygen species (ROS) levels can be protective by "preconditioning" cells to develop a resistance against subsequent challenges. However, the mechanisms underlying such preconditioning (PC)-induced protection are still poorly understood. Previous studies have supported a role of ERK5 (mitogen-activated protein [MAP] kinase 5) in neuroprotection and ischemic tolerance in the hippocampus. In agreement with these findings, our data suggest that ERK5 mediates both hydrogen peroxide (H2O2)-induced PC as well as nerve growth factor (NGF)-induced neuroprotection. Activation of ERK5 partially rescued pheochromocytoma PC12 cells as well as primary hippocampal neurons from H2O2-caused death, while inhibition of ERK5 abolished NGF or PC-induced protection. These results implicate ERK5 signaling as a common downstream pathway for NGF and PC. Furthermore, both NGF and PC increased the expression of the transcription factor, KLF4, which can initiate an anti-apoptotic response in various cell types. Induction of KLF4 by NGF or PC was blocked by siERK5, suggesting that ERK5 is required in this process. siKLF4 can also attenuate NGF- or PC-induced neuroprotection. Overexpression of active MEK5 or KLF4 in H2O2-stressed cells increased Bcl-2/Bax ratio and the expression of NAIP (neuronal apoptosis inhibitory protein). Taken together, our data suggest that ERK5/KLF4 cascade is a common signaling pathway shared by at least two important mechanisms by which neurons can be protected from cell death.
PMID: 25015774 [PubMed - as supplied by publisher]
Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies.
Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies.
Biomed Res Int. 2014;2014:743868
Authors: Rosanio S, Pelliccia F, Gaudio C, Greco C, Keylani AM, D'Agostino DC
This systematic review aims to provide an update on pharmacological and interventional strategies for the treatment of pulmonary arterial hypertension in adults. Currently US Food and Drug Administration approved drugs including prostanoids, endothelin-receptor antagonists, phosphodiesterase type-5 inhibitors, and soluble guanylate-cyclase stimulators. These agents have transformed the prognosis for pulmonary arterial hypertension patients from symptomatic improvements in exercise tolerance ten years ago to delayed disease progression today. On the other hand, percutaneous balloon atrioseptostomy by using radiofrequency perforation, cutting balloon dilatation, or insertion of butterfly stents and pulmonary artery catheter-based denervation, both associated with very low rate of major complications and death, should be considered in combination with specific drugs at an earlier stage rather than late in the progression of pulmonary arterial hypertension and before the occurrence of overt right-sided heart failure.
PMID: 25013799 [PubMed - as supplied by publisher]


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This doctor needs to learn how to LISTEN. She stared at her computer for most of my appointment, and did NOT listen to my symptoms. She gave me a general diagnosis, which I already knew and recommended increasing my walking by 5 minutes a month to get better! INCREDIBLY LUDICROUS! Then she sent my doctor a report that totally contradicted everything she said in the appointment, with me and my husband. In fact this report was UNPROFESSIONAL and OFFENSIVE. Do not take your dog to see this woman. I am appalled that a prestigious institution like Cleveland Clinic would employ such a quack.
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We take these breathtaking photographs of flowers and add the encouraging word of the Lord. Our prayer is that you would be encouraged my these scriptures as you enjoy the beauty of the marvelous creations God has made.
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As line coach with the Vikings, the defense led the league in rushing defense from 2006-2008, allowing a mere 70.8 yards rushing per game. He also had his hand in the development of Pat Williams and Kevin Williams. We all know those guys are pretty good. Imagine if Sione Pouha and Kenrick Ellis became as good as those two…just saying.
Earlier in his career, in 2004 with the Bears, tutored a young Tommie Harris and Tank Johnson, two more guys that turned out to be quite good, wouldn't you say?
The Jets have a young, fast defensive line. Rushing the passer has been a problem for this team in the past, but they have a chance to rectify this in 2012. They need a guy to teach the linemen correctly.
Karl Dunbar is the guy, and a reason to be optimistic about 2012.


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BMW may have plans to release a new sports-tourer based on the S1000RR sports bike platform. The tip-off comes from German motorcycle magazine Motorrad who say the new bike may appear at motorcycle shows as early as this year. The new model is said to feature dynamic damping control, a ride-by-wire throttle with different fuel [...]
BMW to release new S1000F sports-tourer?
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Luxury 1BR Dubai Marina, 1203
Apartment | 1 bedrooms | sleeps 4
|Key Info
Fully furnished 1BR apartment in Dubai directly from the owner located only few minutes from the beach , spectacular partial view to the Persian Gulf and Harbor Yacht Club . Underground parking and a security system 24 hours a day . The apartments on 16th floor have 2 bedrooms , 2 modern bathrooms + 1 guest restroom , lounge , the spacious living and combined dining room , fully equipped kitchen . Furniture meets the high standards. Area Jumeirah Beach Residence is located along one of the last natural beaches in Dubai . The complex has 36 residences , four 5 stars hotels and four beach clubs , playgrounds , fountains and courtyards , shops, restaurants, sports and health clubs. Promenade is a unique place where you can combine a walk along the waterfront with shopping in the world-class boutiques , 20 minutes from the Water Park Atlantis, 7 minutes walk from the subway.
|Sleeps up to 4, 1 bedrooms
|Will consider
|Long term lets (over 1 month), Short breaks (1-4 days)
|Wheelchair users
|Family friendly
|Great for children of all ages, Suitable for people with restricted mobility
|No pets allowed, No smoking at this property
Features and Facilities
|Sea view
|Children's pool
|Air conditioning, TV, Wi-Fi available
|Dishwasher, Microwave, Freezer, Washing machine
|1 bedroom, 1 bathrooms of which 1 Family bathrooms
|1 Sofa beds, Double beds (1), Dining seats for 4, Lounge seats for 4
|Linen provided, Towels provided
|Balcony or terrace
|Wheelchair users, Secure parking, Lift access
Availability Your dates are available
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The Good Wife Discussions
by santanicopandimonium | Mar 18, 2010 10:52AM EDT
Every episode just makes this show better. In "Heart" Peter seems to completely flip his opinion of Will. While Peter was in jail he warned Alicia about Will and how he would stab her in the back. Was this jealousy or was there something more to it. And n more
by StrawBerryCutie | Mar 17, 2010 1:02AM EDT
Anyone who has been watching this show and watched last night's episode will have to agree that this show is absolutely awesome and just keeps getting better and better. SPOILER ALERT: If you haven't watched yesterday's episode DO NOT read on.... But for more
by maxgt | Mar 4, 2010 5:30PM EST
Is The Good Wife the best show on television? That's the bold statement Entertainment Weekly makes in it latest cover story. Featuring a portrait of stars Juliana Margulies and Chris Noth, the magazine quotes the former as saying she was hesitant to ancho more
by guardianofhell | Jan 20, 2010 3:14PM EST
whats going on with tv shows at the moment they seem to be all over the place one week both ncis and ncis la is on the next its not same with the good wife it seems like fridays and sundays are the same cant tv networks sort themselves out the holiday sea more


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This is the hub for news, current information and coverage of all things related to analogue photography and important updates on the latest from Lomography. Learn more about the newest analogue products, read about projects from the community and analogue enthusiasts the world over, watch videos and stay in the know. Also submit your own news story and read over our submission guidlines.
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Snap Up This Incredible Invention: Introducing The Brand New Lomochrome Turquoise Film!We are very excited to present you with our new film, Lomography LomoChrome Turquoise XR 100-400! This emulsion develops in C-41 in 35mm and 120 formats. Limited stock of 5,000 rolls for pre-order are available, so reserve your rolls now; delivery of first stock estimated for April 2015.
Photo of the Day by wolfinthewoodsYou wouldn't want to mess with this confident and fierce lad!
Colorful Transformations: Part OneDon't you love it when the whole world shifts into new perspectives? Perhaps it's the moment you realize the grass isn't always greener on the other side, or that secondly when it's like someone has flicked a switch and life suddenly appears completely fresh again. Well ladies and gentlemen, we are nearly ready to unveil a new Lomographic surprise which will have this magical impact on your photographic life!
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Most Popular Photo Last Year: October 21, 2013Want to take a ride on this ghostly ferris wheel?
The Daily Hex: EminenceBow down to these lomographs bathing in the regal color of Eminence.
Philadephia Museum of Art Opens Paul Strand RetrospectiveFrom today until January next year, the Philadelphia Museum of Art plays host to a major exhibit featuring the work of one of the most influential American modernist photographers. Details after the jump!
René Burri Dies at 81The renowned Magnum photographer passed away yesterday "after a long illness," his family said in a statement.
Photo of the Day by andrejrusskovskijRaise your little arms and giggle in amusement. This baby's smile is just too cute to handle!
vince-bj is our LomoHome of the Day!From everyone here in Lomography, congratulations to vince-bj for winning LomoHome of the Day!
★ A Weekend of Cosplay CompetitionsThere is a weekend in New York where the city streets look like an alternate universe, full of fantastic characters and people who seem to have walked out of a comic book or a movie. This weekend is the NY Comic Con weekend and people from everywhere come to one of the biggest comic convention to be part of one of the biggest Cosplay competitions.
Most Popular Photo Last Year: October 20, 2013Heading for the big wheel? Don't forget to take a quick snapshot first before falling in line!
The Daily Hex: Jelly BeanConsider these lomographs coated in the sugary sapphire color of Jelly Bean as our early Halloween treat!
Monday Moodboard: Vintage Photo RetouchingWhile it's true that photography has grown by leaps and bounds since its inception, there remains something undoubtedly special when it comes to what many might call now as archaic methods.
Testers Wanted!We want YOU to test the future of our Website and help us make it the best place for all Lomographers.
Home of the Day by rommy_stefanusStreet scenes in stunning colors and shadowy vignettes will keep you entertained in today's featured LomoHome. Take a look!
The Analogue Quiz: What B&W Film are you?Did you ever think about the myth that we actually dream in Black & White? No colors, maybe no truth behind it anyways. But we know for a fact that you can create the most dreamy photographs with an analogue camera. And for that you need the right film. Scroll down and find out which B&W film is the film of your dreams!
Snap Up This Incredible Invention: Introducing The Brand New Lomochrome Turquoise Film!We are very excited to present you with our new film, Lomography LomoChrome Turquoise XR 100-400! This emulsion develops in C-41 in 35mm and 120 formats. Limited stock of 5,000 rolls for pre-order are available, so reserve your rolls now; delivery of first stock estimated for April 2015.
Photo of the Day by buckshotHave you ever tried the famous EBS technique on 120 film? Learn a thing or two from buckshot and this striking Photo of the Day!
Meet the UK Team: Joanne CoatesIn this series we meet all the staff that make up Lomography UK. That's everyone from the Soho shop staff to the guys that hide away in the office! Today we talk to shop assistant Joanne Coates who has a penchant for the LC-A+ and loves running our workshops! Say hello to Jo!
Most Popular Photo Last Year: October 19, 2013Stark shadows and strong colors - this panorama is truly one of a kind!
The Daily Hex: Granny Smith AppleMunch on these crisp and juicy Granny Smith Apple lomographs to keep the bad analogue vibes away!
Photo of the Day by tabukNeatly arranged things, whatever they may be, are always a pleasure to look at. Congratulations to tabuk for winning Photo of the Day!
Awesome Albums: 'Everyone is Lomographer!!' by gocchinOur featured album for today is a cool work in portraiture by one of our awesome lomographers from Japan. Have a look!


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This page contains The Chronicles Of Riddick: Escape From Butcher Bay Hints for Xbox 360 called "Snitch list" and has been posted or updated on Jul 30, 2009 by GamerChamp. Let us know what you think of this Hint by thumbs voting.
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Snitch list
There are two parts to the snitch list. One part is hidden in the work pass room where there are the two guards and the mechanic. Search for a loose panel behind the crates. After giving the package to Jagger Valance and getting the mission to get the bomb, return to the second floor as if you are going to the upper mines. On your way back you will encounter two miners standing around. Kill them. One of them has the second part of the snitch list.
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In order for an upstart rapper to make money in 'the game,' every decision needs to be made with an eye towards the future. If millions of dollars are to flood through the doors, a successful cross country and global tour has to be in the works. Preceded of course by a multi-platinum album (with four Top 10 singles,) digital and ring tone sales through the roof and insane radio play on regular play lists and mixshows. A rapper who knows all about such strategies is Yung Joc. As the Atlanta MC prepares for the release of the August 28th bound Hustlenomics, he leaks a second possible single off the album, entitled Play Ya Cards. Produced by Cool & Dre, this ode to sound business decisions is both radio friendly and wise; that is for new comers who are looking to take notes.
Written by DJ Z on 07/30/07
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Whether you believe in ghosts or not, the beauty of these structures will surely haunt your dreams.   See the Gallery
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A Sturgeon Bay woman was not injured when her car struck a utility pole at 3:40 p.m. Saturday in the town of Sevastopol.
Jean M. Tice was traveling north on Bay Shore Drive south of West Dunn Road when her Buick Century went off the right side of the road and struck the pole, according to a Door County Sheriff's Department accident report.
Tice was given a citation for failing to have control.


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Find records of Leila Freeland
Find birth, death, marriage, military, and other records of Leila L Freeland at Ancestry.com.Search for records
Biography & Family History Add details
Leila L Freeland (1902 - 1988) was born on March 8, 1902. She was born into the Freeland family.
There are no known spouses or children on file for Leila. Leila died on June 8, 1988 at 86 years of age.
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HarlemGal Inc has not received confirmation from the owners…yet on when Silvana in Harlem, the new Israeli restaurant, will open. However, we are guessing Silvana's opening day might possibly be near. A reader recently left message on this blog announcing that Uptown Poetry Nights will happen on July 3 at the "all new Silvana Lounge" on 116th Street and Frederick Douglass Blvd. If that is in fact true that a poetry event is being held on July 3 at Silvana, wouldn't the entire venue be open by then or would they just open part of the restaurant for this event? Our guess, Silvana in Harlem will be opening up very soon. Why would one start to promote events unless they knew when they were opening? Stay tuned…
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$124 Average price per night
|Travelodge Hotel Montreal Airport 7300 Côte de Liesse, Dorval (2.9 miles from Montreal Hippodrome)
Score from 381 reviews: GoodJust 3.5 miles from Montréal-Pierre Elliott Trudeau International Airport, this hotel features an on-site Italian restaurant and seasonal outdoor pool. Spacious guest rooms have free Wi-Fi. More…
Latest booking: 12 hours agoThere are 3 people looking at this hotel.
$66 Average price per night
|The Quality Hotel Midtown Montreal 6445 Decarie, Montreal (3.2 miles from Montreal Hippodrome)
Score from 479 reviews:The Quality Hotel Midtown Montréal is a 10-minute walk from Plamondon Metro Station and about a 10-minute drive from downtown Montréal. More…
Latest booking: 12 hours ago
$71 Average price per night
|Le St-Martin Hotel & Suites 1400 rue Maurice-Gauvin, Laval (3.7 miles from Montreal Hippodrome)
Score from 168 reviews: ExcellentSteps from the city's financial and shopping district, this hotel in downtown Laval, Quebec provides a free continental breakfast. Carrefour Laval shopping center is 2 miles away. More…
Latest booking: 12 hours agoThere is 1 person looking at this hotel.
$115 Average price per night
|Motel Pierre 2375 Boulevard Marcel-Laurin, Montreal (0.4 miles from Montreal Hippodrome)
Score from 21 reviews:Located in Montreal, Motel Pierre offers free parking. Free WiFi access is available. A TV, air conditioning and seating area are offered in each room. Select rooms have a mini refrigerator. More…
Latest Booking: October 22There is 1 person looking at this motel.
$55 Average price per night
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