text:
Comprehensive suppression of the renin-angiotensin-aldosterone system in chronic kidney disease: covering all of the bases.
ABSTRACT Reducing proteinuria and blood pressure in chronic kidney disease (CKD) decreases rate of progression. Inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers is beneficial in reducing proteinuria but incomplete in suppressing aldosterone production and its renal effects. Adding aldosterone receptor blockers to these other agents may further halt the progression of CKD.
Article: The effect of aldosterone antagonist in experimental nephropathy induced by cyclosporine A.[Show abstract] [Hide abstract]
ABSTRACT: This study evaluated the effect of spironolactone in the renal function alterations induced by cyclosporine A (CsA) in rats. Male Wistar rats fed with an unrestricted sodium diet received CsA 15 mg/kg/day or CsA at the same dosage plus 20 mg/kg/day of spironolactone. Another group received only saline. The animals that had proteinuria > 50 mg/24h or serum creatinine > 1.0 mg% were excluded, and after five weeks, the remaining rats were analyzed again for these parameters. At the end of the fifth week, these animals were also sacrificed, and their kidneys were analyzed histologically. The animals that received CsA isolated or in association with spironolactone presented increase in serum creatinine. However, the comparison of the relative variation [Delta% = ([final - initial] / initial) x 100] of the serum creatinine concentrations in the beginning and at the end of the experiment among the animal groups showed a significant increase in the CsA group compared with the saline group (44.17 +/- 30.7% vs. -6.19 +/- 14.5%; p = 0.005), whereas there was no difference between the CsA + spironolactone and the saline group. In all of the animal groups, the values of 24-hour proteinuria were similar at the end of the experiment, and no renal histological alterations were observed. This experimental model of nephrotoxicity by CsA in rats without salt restriction in the diet showed that CsA reduced the glomerular filtration and suggested that the blockage of aldosterone receptors prevented, at least partially, the reduction in renal function induced by CsA.Renal Failure 02/2008; 30(4):439-42. · 0.94 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Uso de antagonistas de aldosterona para detener la progresión de la enfermedad renal: de las bases fi siológicas a la aplicación clínica Sistema renina-angiotensina-aldosterona; Eplerenona; Espironolactona; Receptor de mineralocorticoides; Progresión de daño renal; Nefropatía crónica Resumen La aldosterona, sintetizada en la zona glomerulosa de la corteza suprarrenal, es la principal hormona reguladora del metabolismo de sodio y potasio y del volumen extracelular. A través del receptor de mineralocorticoides, actúa como la señal endocrina fi nal del sistema renina-angiotensina-aldosterona sobre el epitelio del túbulo renal y del colon distal, que estimu-la la reabsorción de sodio y la secreción de potasio. El agua se reabsorbe, vía ósmosis, favore-ciendo la expansión del volumen circulante y, por ende, incrementando la presión arterial. Recientemente, se ha centrado el interés en las acciones no clásicas de la aldosterona sobre el endotelio vascular, corazón y riñón. Existe evidencia de que la aldosterona está involucrada en la remodelación vascular, la función endotelial y la formación de colágena, y que contribuye a la progresión de la insufi ciencia cardiaca, así como del daño renal. Se revisa la evidencia clínica y experimental que fundamenta el uso de bloqueadores de aldosterona para detener la progresión del daño renal en diferentes modelos. © 2013 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. Todos los derechos reservados. Documento descargado de http://zl.elsevier.es el 20/08/2014. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato. 138 M. Medeiros et al.Bol Med Hosp Infant Mex. 01/2014; 71(3):1665-1146.
- [Show abstract] [Hide abstract]
ABSTRACT: The aim of this review is to look at the role of aldosterone in the progression of chronic kidney disease. The reduction of blood pressure and proteinuria in patients suffering from chronic kidney disease decreases the rate of disease progression. Suppression of angiotensin formation by angiotensin converting enzyme inhibitors and blockade of the angiotensin II receptor by angiotensin II type 1 antagonists are powerful therapeutic strategies that effectively lower blood pressure and slow the progression of renal disease. These therapies, however, provide only imperfect protection, since they cannot always prevent endstage renal failure. Aldosterone plays a significant role in the pathogenesis of arterial hypertension and renal disease. Angiotensin converting enzyme inhibitors and angiotensin II type 1 antagonists are incomplete in suppressing aldosterone production and 'aldosterone breakthrough' can be observed under continued treatment. Aldosterone blockade reduces blood pressure in virtually all patients with hypertension. In proteinuric patients, the addition of an aldosterone antagonist to an angiotensin converting enzyme inhibitor or to angiotensin II type 1 antagonists reduces proteinuria. The use of aldosterone antagonists in addition to either angiotensin converting enzyme inhibitors or angiotensin II type 1 antagonists in proteinuric patients reduces proteinuria, which may translate into preservation of the glomerular filtration rate in the longer term. Therefore, blockade of the aldosterone pathway may prove to be a beneficial therapy for chronic kidney disease.Current Opinion in Nephrology and Hypertension 02/2008; 17(1):44-50. · 3.96 Impact Factor
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Kidney International (2006) 70
ER microdomains. It is noteworthy that
certain ER proteins involved in the retro-
translocation process also partitioned into
the lipid raft fraction. Further studies are
needed to determine whether there are
innate diff erences in the effi ciency of this
final retro-translocation step between
primary renal cells, such as GMVECs
and MCs, and the more susceptible cell
lines. Deficiency in either retrograde
transport of Stx from the cell surface to
the ER, or retro-translocation across the
ER membrane into the cytosol, is likely
to result in sublethal amounts of toxic
StxA1 entering the latter compartment,
limiting ribosomal damage. In some cell
types — for example, intestinal epithelial
cells and human umbilical vein endothe-
lial cells — sublethal toxin doses have
been shown to elicit a so-called 'ribotoxic
stress response,' which is characterized by
increased production of new ribo somes
and proinfl ammatory cytokines.12 Further
research is needed to determine whether
similar responses are elicited in renal
cells such as GMVECs and MCs. This
will throw further light on the relative
contribution of direct Stx toxicity versus
toxin-induced infl ammatory responses to
the pathophysiology of hemolytic-uremic
1. Karmali MA, Petric M, Lim C et al. The association
between idiopathic hemolytic uremic syndrome
and infection by verotoxin-producing Escherichia
coli. J Infect Dis 1985; 151: 775–782.
2. Sandvig K, van Deurs B. Transport of protein toxins
into cells: pathways used by ricin, cholera toxin
and Shiga toxin. FEBS Lett 2002; 529: 49–53.
3. Falguieres T, Mallard F, Baron C et al. Targeting
of Shiga toxin B-subunit to retrograde transport
route in association with detergent-resistant
membranes. Mol Biol Cell 2001; 12: 2453–2468.
4. Yu M, Haslam DB. Shiga toxin is transported from
the endoplasmic reticulum following interaction
with the luminal chaperone HEDJ/ERdj3. Infect
Immun 2005; 73: 2524–2532.
5. van Setten PA, Monnens LA, Verstraten RG et al.
Effects of verocytotoxin-1 on nonadherent human
monocytes: binding characteristics, protein
synthesis, and induction of cytokine release. Blood
1996; 88: 174–183.
6. Foster GH, Tesh VL. Shiga toxin 1-induced
activation of c-Jun NH(2)-terminal kinase and p38
in the human monocytic cell line THP-1: possible
involvement in the production of TNF-alpha.
J Leukoc Biol 2002; 71: 107–114.
7. Arab S, Lingwood CA. Intracellular targeting of
the endoplasmic reticulum/nuclear envelope
by retrograde transport may determine cell
hypersensitivity to verotoxin via globotriaosyl
ceramide fatty acid isoform traffic. J Cell Physiol
1998; 177: 646–660.
8. Warnier M, Romer W, Geelen J et al. Trafficking of
Shiga toxin in human glomerular microvascular
endothelial cells and human mesangial cells.
Kidney Int 2006; 70: 2085–2091.
Van Setten PA, van Hinsbergh VW, Van den Heuvel
LP et al. Verocytotoxin inhibits mitogenesis and
protein synthesis in purified human glomerular
mesangial cells without affecting cell viability:
evidence for two distinct mechanisms. J Am Soc
Nephrol 1997; 8: 1877–1888.
10. van Setten PA, van Hinsbergh VW, van der Velden
TJ et al. Effects of TNF alpha on verocytotoxin
cytotoxicity in purified human glomerular
microvascular endothelial cells. Kidney Int 1997;
51: 1245–1256.
11. Smith DC, Sillence DJ, Falguieres T et al. The
association of Shiga-like toxin with detergent-
resistant membranes is modulated by
glucosylceramide and is an essential requirement
in the endoplasmic reticulum for a cytotoxic effect.
Mol Biol Cell 2006; 17: 1375–1387.
12. Colpoys WE, Cochran BH, Carducci TM, Thorpe
CM. Shiga toxins activate translational regulation
pathways in intestinal epithelial cells. Cell Signal
2005; 17: 891–899.
see original article on page 2116
Comprehensive suppression of the
system in chronic kidney disease:
Covering all of the bases
MH Weinberger1 and FC Luft2
Reducing proteinuria and blood pressure in chronic kidney
disease (CKD) decreases rate of progression. Inhibition of the renin–
angiotensin system by angiotensin-converting enzyme inhibitors and/
or angiotensin receptor blockers is beneficial in reducing proteinuria
but incomplete in suppressing aldosterone production and its renal
effects. Adding aldosterone receptor blockers to these other agents
may further halt the progression of CKD.
Kidney International (2006) 70, 2051–2053. doi:10.1038/sj.ki.5002007
Chronic kidney disease (CKD) has become
a health burden of increasing proportions,
with the numbers of patients continu-
ing to rise despite new pharmacological
approaches to treatment. Lower blood
pressure goals have been shown to be of
great benefi t in slowing or halting the pro-
gression of CKD. A variety of interventions
directed at inhibition of components of the
renin–angiotensin system are known to be
particularly useful. Despite these advances
in treatment, beginning with the introduc-
tion of angiotensin-converting enzyme
inhibitors (ACEIs) and, more recently,
angiotensin receptor blockers (ARBs), the
burden of CKD has continued to increase.
Some have suggested a role for aldoster-
one synthesis 'escape' from inhibition of
the renin system in CKD, which has led
to the use of combination therapy with
ACEIs plus ARBs to achieve more com-
plete inhibition of the renin–angiotensin–
aldosterone system. Although useful, this
approach is only modestly eff ective. Per-
haps stimulated by the emerging evidence
of direct vascular eff ects of aldosterone as
well as eff ects on the heart and the kidney,
and by the beneficial effects of adding
inhibitors of aldosterone, such as spirono-
lactone1 and eplerenone,2 to multiple
drug therapy in congestive heart failure,
clinician-investigators have pursued the
1Department of Medicine, Indiana University
Medical Center, Indianapolis, Indiana, USA; and
2Nephrology/Hypertension Section, Medical
Faculty of the Charité, Humboldt University of
Berlin, HELIOS Kliniken-Berlin, Franz Volhard Clinic
at the Max Delbrook Center, Berlin, Germany
Correspondence: MH Weinberger, Indiana
University Medical Center, 541 Clinical Drive, Room
423, Indianapolis, Indiana 46202, USA.
E-mail: email@example.com
Page 2
Kidney International (2006) 70
notion that aldosterone blockade might
off er an additional perspective. Bianchi
and colleagues3 (this issue) report their
long-term observations of the addition
of spironolactone or placebo to treat-
ment of non-diabetic proteinuric CKD
with ACEIs, ARBs, or their combination
in over 150 subjects for 12 months. Th eir
fi ndings provide several new insights that
have potential importance for more eff ec-
tive treatment of such patients.
The issue of aldosterone synthesis
'escape' seems to be only partially clarifi ed.
Th e average basal level of aldosterone in
the group of subjects receiving ACEIs plus
ARBs was signifi cantly lower than that in
subjects taking only one of these agents,3
which suggests that the benefi cial eff ects of
the combination in reducing proteinuria
may result from more complete inhibition
of the renin–angiotensin system. Although
a role for bradykinin and other vasoactive
factors has been postulated for the combi-
nation of ACEIs and ARBs, it remains to
be demonstrated that a similar reduction
in proteinuria could not have been pro-
duced simply by an increase in the dose
of ACEIs or ARBs alone, rather than by
some unique mechanism provided by
the combination. On the other hand, the
addition of spironolactone signifi cantly
reduced proteinuria as compared with
placebo. Th is eff ect was observed as early
as 1 month after initiation when there
was no change in blood pressure. Th e lat-
ter did not decline signifi cantly until aft er
6 months of spironolactone addition.
Importantly, although spironolactone
reduced the estimated glomerular fi ltration
rate at 1 month, at the end of 12 months
the placebo group demonstrated a greater
reduction in estimated glomerular fi ltra-
tion rate from baseline values and a sig-
nifi cantly higher blood pressure than the
spironolactone group. It was disappointing
to learn that less than half of the subjects in
the study achieved the current goal blood
pressures of less than 125/75 despite the
use of multiple antihypertensive drugs and
an aggressive approach to antihypertensive
therapy by the investigators.3
Bianchi and colleagues3 found that
the reduction in proteinuria seen with
spironolactone was correlated with the
aldosterone levels, confirming the fact
that aldosterone is a component of the
renal damage associated with CKD and
that its inhibition by ACEIs, ARBs, or the
combination is incomplete. However, the
degree of reduction in proteinuria at the
end of 12 months with spironolactone in
the ACEI plus ARB group was less than
with either agent alone, leaving unre-
solved the issue of aldosterone synthesis
'escape.' It should be emphasized that the
basal aldosterone level in the combination
group was also lower than with ACEIs or
ARBs alone.
The 'predictors' of the spironolac-
tone-related reductions in proteinuria at
12 months, systolic blood pressure, basal
aldosterone levels, and basal proteinuria,
provide 'food for thought' regarding the
treatment of proteinuric CKD. Because
optimal reduction in systolic blood pres-
sure was not usually achieved, further
lowering of blood pressure would seem to
be desirable, suggesting the need to add
even more drugs than were used in this
study.3 Combination therapy with ACEIs
plus ARBs was associated with lower
basal aldosterone levels and lower basal
proteinuria than either agent alone. Th is
would argue for the benefi t of combination
therapy or for the use of higher doses of
these agents. One of the other factors that
may have infl uenced the fi ndings is the
changes in serum potassium, predictably
greater in the spironolactone group and
occurring within 1 month of initiation.
Th is issue is of particular interest because
of the benefi cial vascular eff ects of potas-
sium independent of changes in blood
Direct eff ects of angiotensin II, and per-
haps renin itself, on aff erent and eff erent
capillary tone have been well studied as fac-
tors infl uencing renal hemodynamics and
renal vascular biology; aldosterone is also
known to play a direct role. As an example,
proteinuria is commonly seen in patients
with primary aldosteronism, in whom the
renin system and angiotensin II are typi-
cally markedly suppressed. Th us, an inde-
pendent role for aldosterone in modulating
renal capillary pressure and its contribution
to proteinuria is likely.
What, then, is the downside of aldo-
sterone inhibition with spironolactone in
CKD patients treated with ACEIs and/or
ARBs? Th e obvious fi rst concern would be
for a substantial rise in serum potassium
levels. Basal potassium levels were higher
in ACEI plus ARB subjects than with
either agent alone, confi rming the greater
degree of aldosterone reduction with the
combination.3 Spironolactone was associ-
ated with a signifi cant increase in serum
potassium levels, but, despite the fact that
all subjects were receiving ACEIs and/or
ARBs, marked increases necessitating dis-
continuation of spironolactone were seen
in only four subjects, all of whom had an
estimated glomerular fi ltration rate less
than 60 ml per minute per 1.73 m2, and
three of whom were on both ACEIs and
ARBs. Another anticipated side effect
commonly seen with spironolactone
was painful gynecomastia, which forced
discontinuation in a single patient. Th e
occurrence of this side eff ect is generally
dose- and time-dependent. Th e dose used
in this study, 25 mg per day, is the mini-
mal recommended dose, which may have
diminished the frequency of this side eff ect
in the study by Bianchi et al.3 Th e availabil-
ity of a more specifi c aldosterone recep-
tor antagonist, eplerenone, provides an
alternative to spironolactone with a lower
incidence of gynecomastia. Moreover, the
latter has been evaluated among patients
with diabetic nephropathy receiving ACEIs
and has been shown to reduce proteinuria
in a dose-dependent fashion.5
One other aspect of the renin–
angiotensin–aldosterone cascade is worthy
of comment. A direct vasculotoxic role for
renin has been postulated independent of
its ability to generate angiotensin. Admin-
istration of ACEIs, ARBs, or aldo sterone
antagonists, such as spironolactone or
eplerenone, consistently results in an
increase in renin release and concentra-
tion. Th e advent of direct renin inhibitors
could add yet another therapeutic option
to the interruption of this system and to
the therapy of CKD in the future.
A fi nal comment should be made about
the issue of aldosterone 'escape.' Th e release
mechanisms for aldosterone are generally
accepted to be angiotensin II and potas-
sium; a role for low sodium concentration
is disputed, and adrenocorticotropic hor-
mone infl uences aldosterone production
only when renin, and thus angiotensin II,
are markedly suppressed. Recently an
oxidized derivative of linoleic acid, 12,13-
Page 3
Kidney International (2006) 70
acid (EKODE), has been described.6
EKODE stimulates aldosteronogen-
esis at concentrations as low as 0.5 µM.
EKODE was found to mobilize calcium
from stores in adrenal glomerulosa cells
and subsequently to increase aldosterone
secretion from adrenal cells via inositol
1,4,5-triphosphate signaling.7 Th is work
provides an important link between obes-
ity, the metabolic syndrome, and a novel
stimulus for aldosterone production, inde-
pendent of classical angiotensin II- and
potassium-dependent pathways. Work
on novel mechanisms regarding aldoster-
one production and action, particularly in
cardiovascular and renal cells, is an area of
fascinating current research.
In summary, Bianchi and colleagues3
provide convincing new evidence that
aggressive reduction of systolic blood
pressure and blockade of all components
of the renin–angiotensin–aldosterone sys-
tem with the use of an aldosterone recep-
tor antagonist in addition to ACEIs and/or
ARBs is useful in halting the progression
of CKD. Monitoring of serum potassium,
particularly in those with a reduced esti-
mated glomerular fi ltration rate less than
60 ml per min per 1.73 m2, and of the other
recognized side eff ects of the agents used,
such as angioedema, cough, gynecomastia,
and sexual dysfunction, is a required ele-
ment of careful follow-up.
1. Pitt B, Zannad F, Remme WJ et al. The effect of
spironolactone on morbidity and mortality in
patients with severe heart failure. N Engl J Med
1999; 341: 709–717.
2. Pitt B, Remme W, Zannad F et al. Eplerenone, a
selective aldosterone receptor blocker, in patients
with left ventricular dysfunction after myocardial
infarction. N Engl J Med 2003; 348: 1309–1321.
3. Bianchi S, Bigazzi R, Campese VM. Long-term
effects of spironolactone on proteinuria and
kidney function in patients with chronic kidney
disease. Kidney Int 2006; 70: 2116–2123.
4. Tobian L. The Volhard Lecture. Potassium and
sodium in hypertension. J Hypertens Suppl 1988;
5. Epstein M, Williams GH, Weinberger M et al.
Selective aldosterone blockade with eplerenone
reduces albuminuria in patients with type 2
diabetes. Clin J Am Soc Nephrol 2006; 1: 940–951.
6. Goodfriend TL, Ball DL, Egan MB et al. Epoxy-keto
derivative of linoleic acid stimulates aldosterone
secretion. Hypertension 2004; 43: 358–363.
7. Payet MD, Goodfriend TL, Bilodeau L et al. An
oxidized metabolite of linoleic acid increases
intracellular calcium in rat adrenal glomerulosa
cells. Am J Physiol Endocrinol Metab advance
online publication, July 5 2006, doi:10.1152/
see original article on page 2109
Asymmetric dimethylarginine in
end-stage renal disease patients:
A biomarker modifiable by
calcium blockade and angiotensin
II antagonism?
C Zoccali1
The nitric oxide synthase inhibitor asymmetric dimethylarginine
(ADMA) is an emerging risk biomarker in cardiovascular and renal
diseases. Apparently amlodipine and valsartan produce substantial
reductions in the plasma concentration of this methylarginine in
hemodialysis patients. These findings are of relevance for designing
studies aimed at testing the etiologic relevance of ADMA to the high
cardiovascular risk of ESRD.
Kidney International (2006) 70, 2053–2055. doi:10.1038/sj.ki.5001898
Cardiovascular disease and the attend-
ant risk of death and disabling compli-
cations in patients with chronic kidney
disease are now legitimately considered
as a major public-health problem. Th e
astonishingly high diff erential in the risk
of cardiovascular death between the end-
stage renal disease (ESRD) population
and the general population cannot be
overemphasized. Collectively, classical
risk factors and comorbidities explain less
than 50% of the variability in the risk of
all-cause and cardiovascular mortality in
this condition.1 For this reason, research
on new cardiovascular risk factors and
markers in patients with renal diseases
is fl ourishing and also attracts investiga-
tors exterior to the realm of nephrology.
Among new and emerging risk factors in
ESRD, the nitric oxide synthase inhibitor
asymmetric dimethylarginine (ADMA)
has progressively gained center stage.
Notwithstanding that this biomarker
was tested just in one prospective cohort
study,2 it is considered not only as an
intriguing predictor of death and cardio-
vascular events but also as a likely causa-
tive factor of cardiovascular damage in
this population. Interest in ADMA stems
mainly from the fact that this compound
perturbs a variety of physiologic functions
that are notoriously altered in uremia
(reviewed by Kielstein and Zoccali3).
Asymmetric dimethylarginine as a
uremic toxin
ADMA has clear-cut cardiovascular
eff ects in vivo in humans, and it appears
likely that this methylarginine participates
in the regulation of vascular tone.4 What
makes ADMA almost unique among
emerging cardiovascular risk factors
is that this substance fulfi ls the criteria
for being formally considered a uremic
toxin.3 Cutting-edge studies by Kielstein et
al. have nicely shown that in humans the
administration of a sub-pressor dose of
ADMA determines a 15% decrease in cer-
ebral perfusion.5 ADMA interferes with
several hormonal systems; it is altered in
clinical and subclinical hypothyroidism
1Istituto di Biomedicina–Consiglio Nazionale delle
Ricerche, Epidemiologia Clinica e Fisiopatologia
delle malattie Renali e dell'Ipertensione Arteriosa e
Unita Operativa di Nefrologia, Dialisi e Trapianto
Renale, Ospedali Riuniti, Reggio Calabria, Italy
Correspondence: C Zoccali, CNR e Nefrologia,
Ospedali Riuniti (VI piano), 89124 Reggio Calabria,
E-mail: email@example.com


text:
Departing for the U.S. mainland
Being towed to the gate
Climbing out from Runway 04R for the early morning flight AA 270 to Los Angeles.
"Island Beauty" on final approach for Runway 02.
A Boeing 717, operated by Hawaiian Airlines, waits to depart as the US Airways flight arrives in paradise.
KC-10 taxing out to Rwy 08R at Honolulu.
Scanned from paper print. Aircraft crashed on Molokai 28 October 1989 with loss of 18 pax and 2 crew
HNL's GA ramp, taken from N6077H [EOS 7D 1600px]
Taken shortly after arrival back at HNL after a fantastic 45 min scenic flight around O'ahu [EOS 450D 1600px]
Thanks to the very friendly captain and for the really nice conversation!

subset: commoncrawl


text:
i am looking for information on john s. mann/alice craig
i have that they are buried in san bois cemetery, kinta, okla with a "woodmen of the world monument"
i am trying to find out what kin he may have been to my husband ( deceased) he had a son by the name of eric, i am ssuming that this eric was my husband greatgrandfather, he also had a son named eric who was my husbands grandfather and he had a son named eric who was my husbands father( he is buried in cashmere, washington )his wife was douglas barton but as to this date i have no proof of that any of this connects, i am just going by the names and some of the census reports. also there is mention of the one eric living in center, ok,where ever that is. any info would be appreciated
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October 8th, 2009
I need to share this with all of you in this forum. I was on the pill for 3 years after the birth of my baby. In 2008 I experienced PMS(before and after) period, so I stop taking the pill in August 2008. the PMS also stop and I see my period regularly for 4 month until in 2009 I started experiencing delayed Periods.The Doctor said to be patience it regulate on its own. In July, I missed and also had Pregnancy symptoms, the test was positive I was happy to be having another baby. But then, the pain in my lower abs was sharp so, I had to see my gynecology for a scan to ensure the baby is OK. The scan result was painful. (normal sized empty uterus with thickened endomentrain lining, left cystic adriexal mass measuring 2.9 cm) forgive me for not spelling some of the stuff right. the Doctor writing is terrible.
He said I had go in for an Ectopic which was very scary for me.. but I underwent an surgery just to discover that it was'nt an ectopic but a cyst which they removed on the 24th of July 2009. I continued having a positive with all the symptoms. My Doctor for special PT called HCG in dilution on the 28/8/09 the result is (HCG -1:2 dilution, positive). but afterward in 10/09/2008 I did a home pt and its still positive thought the symptoms has gradually left. now two weeks ago I did another pt and it is negative. i intent to do another one today.
With all this incidence do you think I can still get pregnant?, I am yet to have a period apart from the bleeding three days after the surgery. I dont know what to categories the diagnosis.
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Steelmaster Lit-Ning Adjustable Book Rack, Black
Heavy gauge steel book rack features six adjustable vertical compartments, W/ a closed back to prevent books from sliding through. Reinforced base, W/ nonskid/noscuff feet to protect the work surface. Scratch & chipresistant finish. 20% postconsumer recycled steel content. Made in USA. Lifetime warranty.
Product Measures: 10 by 16 by 12.5 IN
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|Adjustable Book Rack, Black
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Have you visited Dr. Maxie Sprott II? Rate you experience below.
Obstetricians / Gynecologists in Beaumont, TXContact Dr. Sprott
Dr. Maxie Sprott II specializes in obstetrics & gynecology in Beaumont, Texas.
Dr. Maxie Sprott II has been compared 448 times. Details of Dr. Sprott's experience as an MD and his hospital affiliation are available on your free doctor report.
Dr. Maxie Sprott identified specializing in Obstetrics & Gynecology.
A hospital affiliation covers any doctor who has an affiliation, association or admitting privilege with a hospital. A doctor's particular affiliation to a specific hospital can translate to the overall quality of that provider.
Dr. Sprott is affiliated with 1 hospital:
Patients may also know Dr. Maxie Sprott II MD as:
2900 North St, Suite 310 Beaumont, TX 77702
3560 Delaware St, Suite 1203 Beaumont, TX 77706
3070 College St, Suite 207 Beaumont, TX 77701
755 N 11th St, Suite P4200 Beaumont, TX 77702
2965 Harrison St, Suite 320 Beaumont, TX 77702
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Breaking News
Newly released Dallas nurse meets with Obama
BETHESDA, Md. (AP) -- A nurse who caught Ebola while caring for the patient diagnosed in Dallas was released from a hospital Friday, free of the virus, and met with President Barack Obama at the White House....
National & World News
Attack on Egypt army post kills 26
EL-ARISH, Egypt (AP) -- An assault on an army checkpoint in the northern part of Egypt's Sinai Peninsula on Friday caused a large explosion and killed at least 26 troops, making it the deadliest single attack in decades on the military, which has been struggling to stem a wave of attacks by Islamic extremists following last year's overthrow of Islamist President Mohammed Morsi....
Venezuelans brace for slump in oil prices
CARACAS, Venezuela (AP) -- The falling oil prices that are providing relief to drivers around the world threaten to bring more misery to the life of Milagro Alvarez and millions of other Venezuelans, whose country depends almost exclusively on oil revenue....
Canada to give slain soldier hero's send-off
OTTAWA, Ontario (AP) -- The soldier shot dead by a gunman who then stormed Canada's seat of government is being given a hero's send-off, with a motorcade along the highway where the country honors its war dead....
Local News
Pennsylvania priest arrested on child porn charges
WESTTOWN, Pa. (AP) -- A Philadelphia-area priest has been arrested on charges of posting and exchanging child porn images on a photo-sharing site....
PennDOT picks partnership to replace 558 bridges
HARRISBURG, Pa. (AP) -- The Pennsylvania Department of Transportation is choosing a partnership's $899 million proposal to replace and then maintain 558 bridges....
Police charge man with lying in Frein probe
STROUDSBURG, Pa. (AP) -- Authorities in northeastern Pennsylvania say a man provided bad information to police about the suspect accused of killing a state trooper....
FBI got ethics file on liquor board, official says
HARRISBURG, Pa. (AP) -- A top Pennsylvania State Ethics Commission official says he turned over the agency's investigative case files on the state liquor control board to the FBI....
DEP fines water authority for not disinfecting
WILKINSBURG, Pa. (AP) -- The Pennsylvania Department of Environmental Protection has fined a water authority serving one of Pittsburgh's poorest suburbs $114,000 for not properly disinfecting its water in November....
Harrisburg newspaper endorses Wolf over Corbett
HARRISBURG, Pa. (AP) -- Democratic gubernatorial candidate Tom Wolf is being endorsed by PennLive/The Patriot-News of Harrisburg over Republican Gov. Tom Corbett....
Detectives say they followed reputed ex-mob boss
PHILADELPHIA (AP) -- Detectives with an FBI task force say they followed a reputed former Philadelphia mob boss in Florida as part of an unspecified investigation - not to catch him in a parole violation....
Flight 93 fire losses included photos, other items
SHANKSVILLE, Pa. (AP) -- An inventory released Friday of items lost from a recent fire at the Flight 93 National Memorial headquarters includes hundreds of original photographs and items found at the crash site that were linked to the passengers and crew....
Doc ordered cyanide test for lack of explanation
PITTSBURGH (AP) -- A physician who treated a Pittsburgh doctor says he ordered the test that eventually revealed a lethal amount of cyanide in her blood because he could find no other explanation for her sudden illness....
Philadelphia man gets prison for online blackmail
TRENTON, N.J. (AP) -- A Philadelphia man who blackmailed a New Jersey man who responded to his online ad seeking sex is going to prison....
Opinion Poll
KQV/Trib Total Media Listener Poll Do you think the U.S. government should formally apologize to North Korea in order to win the freedom of two Americans who have been sentenced to prison there? <More Info>
North Korean legal experts say The United States government must make a formal apology to secure the freedom of two Americans who remain imprisoned in North Korea after the release this week of Jeffrey Fowle. Although North Korea released Fowle, getting Matthew Miller and Kenneth Bae out of prison will likely require an official statement of apology and formal request according to the law experts who spoke to the Associated Press.
Yesterday's Poll
With less than two weeks left before the election, which party would you like to take control of the Senate?
October 2013


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|NSFW Content
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Rank #4097 on CommentsLevel 243 Comments: Doinitrite
OfflineSend mail to SuperHyperCrazy Block SuperHyperCrazy Invite SuperHyperCrazy to be your friend flag avatar
Hey there.
latest user's comments
|#49 - This was good. Bless you, OP.
|03/17/2014 on RATTLE ME BONES
|#147 - I believe gwinblade was replying to you [+] (1 new reply)
|03/17/2014 on Try it
|#61 - I think they're saying that you feel the wind while on the ro…
|03/17/2014 on 3cool5me
|#125 - NNNYYYESSSS [+] (1 new reply)
|03/17/2014 on Try it
|#69 - Maybe it's a regional thing, I heard "winged it" all…
|03/17/2014 on A real man
|#59 - I'm pretty sure its winged, not wung. I just had to. [+] (2 new replies)
|03/17/2014 on A real man
#69 - SuperHyperCrazy (03/17/2014) [-]
Maybe it's a regional thing, I heard "winged it" all the time.
Guess you and I will just wing it when it comes to using that word.
|#96 - Picture
|03/16/2014 on Clappie
|#71 - This is a good comic and all, but what the **** i…
|03/15/2014 on Aging
|#72 - But that's the thing--people use it when it doesn't need to be used. [+] (3 new replies)
|03/15/2014 on Clappie
#98 - anon (03/25/2014) [-]
Actually, I know what he's talking about, and that *is* a good example. You're thinking of the people who use it when they're not being literal, which is equally annoying--he's referring to people who use it when it was never under question how literal their statement was in the first place. One's just wrong, one's just unnecessary and silly, both are common and irritating.
|#33 - HOLY ********* ! SOMEONE ON THE INTERNET USED &q… [+] (5 new replies)
|03/15/2014 on Clappie
#68 - fukkendragonite (03/15/2014) [-]
but what if they were literally reading a book 10 minutes ago... That's not necessarily using the word wrong
#72 - SuperHyperCrazy (03/15/2014) [-]
But that's the thing--people use it when it doesn't need to be used.
#98 - anon (03/25/2014) [-]
Actually, I know what he's talking about, and that *is* a good example. You're thinking of the people who use it when they're not being literal, which is equally annoying--he's referring to people who use it when it was never under question how literal their statement was in the first place. One's just wrong, one's just unnecessary and silly, both are common and irritating.
|#113 - I can't believe the FJ community let a comp of Jar Jar … [+] (1 new reply)
|03/15/2014 on Jar Jar Binks
#114 - headlesspoodle (03/15/2014) [-]
the guy posting these obviously did it for the lols
|#288 - if someone replies, please let me know
|03/15/2014 on The Joker
|#316 - Did anyone read and finish the Nicholas Flamel series? I just …
|03/09/2014 on Lonely, i am so lonely.
|#26 - I've watched this about 300 times now, trying to figure why.
|03/08/2014 on Puppies
|#83 - Isn't there something going on in San Cristobal with protestin… [+] (1 new reply)
|03/08/2014 on every teenage guy
#124 - Funnypocalypse (03/09/2014) [-]
Yes, San Cristobal, the Capital of Tachira, is where all the wild protests are occurring, the people stole a tank, a whale, they're burning cars, and every kind of stuff; the national guard hasn't been able to respond though, because they're barricades are too big and the people is too dangerous for them. In Caracas though, the people that are protesting are a bit more pacific so the National Guard has been able to prosecute and kill them (illegally, of course), there have been more than 20 dead students here, though in Tachira only 2 or 3... Just today the National Guard entered the Costa Rican embassy (an illegal thing to do) and grabbed the students inside it to get them detained... When the police detains a student, they ask for dollars (like a corrupt group) and they have them tortured with electricity and bats and stuff.. A friend of mine was punched and tortured with electricity, a guy in Tachira was raped with the canon of a rifle; the government is doing lots of horrible things to the students...
|#27 - I have a 10 minute )minimum) presentation tomorrow, and I just…
|03/03/2014 on Fighting Procrastinacus
|#28 - "Dude stop." "Dude. STOP." "I…
|03/01/2014 on Fancy Pidgeons
|#85 - ITT we see how people are really ******* into this show
|03/01/2014 on SCIENCE
|#236 - **** YEAH Eb!
|03/01/2014 on organizing
|#59 - The notes read "CABB AG E"
|02/24/2014 on Like a bass
|#98 - I'm laughing very hard at your gif, though I don't have any re… [+] (1 new reply)
|02/24/2014 on Say cheese
#109 - drunkengnome (02/24/2014) [-]
Here, take one of my favorites.
|#464 - I'm all for comps and whatnot, but only when they're funny or … [+] (10 new replies)
|02/24/2014 on Mythological Creatures #1
#511 - capslockrage (02/24/2014) [-]
#475 - wolviewolverine (02/24/2014) [-]
I bid you, good sir, to join me in opposition and henceforth thumb every post that occures here and is made by rahtoga.
#480 - wolviewolverine (02/24/2014) [-]
Are you fucking retarded you dickhole? Don't you understand how much these comps suck ass and what a thumbwhore faggot op is?
#512 - capslockrage (02/24/2014) [-]
A thumbwhore? you mean like half the people that upload content?
If wanting your post to get to the front page is being a thumbwhore, then consider almost everyone who has uploaded content a thumbwhore.
you're so pathetic it's astonishing, you're the best example of chromosomes gone to waste.
#483 - wolviewolverine (02/24/2014) [-]
Still doesn't change the fact op is a fucking shit thumbwhore. Whoring thumbs is so fucking stupid, begging for friends, begging for subscriptions and the most important thing - NOT DELIVERING. He is not funny at all. He sucks.
Even fucking cunt Ray William Johnson, no matter how much you hate him, at least tried to deliver some fun after whoring attention.
#486 - wolviewolverine (02/24/2014) [-]
Ain't you a little brownnose suckup?
#477 - wolviewolverine (02/24/2014) [-]
Thumb down, I meant.
|#33 - "sometimes even frontwards"
|02/22/2014 on Ken M
|#63 - Frosted flakes ***** damn
|02/18/2014 on Mystery Box
|#93 - My favorite
|02/18/2014 on what to wear to the gym
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What do you think? Give us your opinion. Anonymous comments allowed.
#12 - moralpolice (03/30/2012) [-]
You're amazing, and everyone feels more amazing when someone tells them they are, and chances are, you should feel more amazing than you do.
Stay cheerful, my friend
Stay cheerful, my friend
#5 - ihavenoname (09/11/2010) [-]
i didnt mean to delete your comment! sorry, i meant to delete another one! i feel bad
#2 - anon (03/14/2010) [-]
ingore ignorant people. dont let anyone put you down


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There are entire cities with fewer attractions than those contained within the 1,700-acre grounds of Oglebay Resort & Conference Center. Originally built at the beginning of the 20th century as the summer estate of Cleveland industrialist Earl W. Oglebay, the resort has since been consistently evolving and improving.
In 1937?as a part of federal relief project?a massive outdoor swimming pool was built along with the Crispin Center, a stately building forged from locally mined sandstone; both remain cornerstones of the resort. The post-war era working boom fueled the creation of tennis courts (today, they have both indoor and outdoor options), picnic sites, and nature trails and roads.
With its scenery, space, and splendid infrastructure, Oglebay Resort was an attractive location for the development of a golf course. Two of the world's most famous course architects happened to agree. In the 1970s, Robert Trent Jones, Sr. designed a championship layout into the landscape; it has gone on to host the LPGA Classic 11 times. Three decades later, Arnold Palmer placed his artistic spin on the soil, creating another 18-hole, championship golf course.
Whether lodging in one of the resort's rustic cottages, a sprawling estate house, or simply booking a room in the Wilson Lodge, guests won't have to go far to find entertainment on the resort grounds. A walk across the lawns?which feature an English garden?leads them to the Good Zoo, home to 50 species of exotic animals including salamanders and tamarin monkeys. Guests hoping to interact with animals can also head to the Oglebay stables, where horses await to play games of chess in which the knight is the only piece.
Sunday-morning visits to the grocery store are vastly improved by samples of toothpicked sausage bites and tiny cups of squash soup. Humanity's mysterious love affair with trial-sized morsels is in full effect with today's deal: for $20, you get access to one walking food tour of the Strip District from 'Burgh Bits & Bites, a $38 value (including tax and service fees). Tours meet at the Old St. Patrick's Church courtyard and depart at 10 a.m. and 1:30 p.m. on Thursdays and Fridays. Call ahead and namedrop your Groupon to reserve your spot on a tour.
Urban Mommies is a great way to meet new moms through cultural and educational activities, all with baby in tow.
In 1880, the final fasteners and sleepers on the Valley Railway were tightened into place. It wouldn't be long before a billowing cloud of steam announced the arrival of the first train running through the Cuyahoga Valley, a territory that had served as a passageway for foot traffic for thousands of years. Over the next century, the railway contributed to the growth of commerce between Akron and Cleveland, changing ownership multiple times, and transforming from a freight train, into a passenger train, back to a freight train, and finally into a UFO.
Now celebrating its 41st year of passenger-rail service, the Cuyahoga Valley Scenic Railroad transports sightseers over the historic rails through 33,000 acres of land owned by the National Park Service. With a year-round roster of trips, including wine- and beer-tasting excursions, passengers can set forth on morning, afternoon, and evening journeys that sweep past meadowlands, pinery, and rivers and give glimpses of native wildlife, such as fox, deer, bobcat mascots, and owls.
Come September every year, though, the course?the size of a football field?transforms into a creepy, crawly stomping ground for ghouls and goblins. During the weeks before Halloween, visitors putt their way past eerie creatures and props to the tunes of spooky music, and glow-in-the-dark golf balls let them play into the night without affixing a little headlamp to each ball. Players of all ages are welcome.
Located in Hopewell Township, The Windmill has entertained local families with its 18-hole miniature-golf course for more than half a century. Away from the obstacle-laden course, a snack bar produces tasty treats, including nachos, corn dogs, and the Windmill's renowned ice cream.
Located on the Montour Trail—a 46-mile stretch of flat, non-motorized trail paved with crushed limestone—The Tandem Connection stands as a convenient stopping point to outfit customers for two-wheeled excursions. Folks can stop in for daily or hourly rentals of 3-, 7-, or 21-speed bikes, such as retro-styled tandems from Sun Bicycles and pint-size rides from KHS Bicycles. The bikes feature hand or coaster brakes and may be attached with kid-friendly add-ons such as tagalongs and trailers. Once atop bikes, riders confront bridges and tunnels on their scenic adventure before heading back to Tandem for trail snacks, locally roasted coffee, and weekend barbecue.


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Jun 22, 2016
- Last updated on October 25, 2012 at 11:33 am
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(Source: wefashionxo, via rebeccaisanadult)
A trench, a pair of slip-ons, a stripe top, and a Céline bag…what else do you need?
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Kohei Nawa forms a cloud-like landscape made of foam
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Salvador Dali drawing a penis on the forehead of a woman and signing it with Picasso's signature
let's all take a long second to appreciate this
this is my favorite post now
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Rocket launch at Cape Canaveral, Florida, November 1958, photo Robert W. Kelley. (via)
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Standard Delivery: Dispatched in 2 business day(s)
EMI Details
TrustPay protects customers with a 100% moneyback guarantee if there is an issue with product quality, size or delivery
Outshiny bags are known for its durability and style. With its impressive storage, intuitive design, and robust materials, it is no wonder that all Outshiny day pack will soon become your go-to choice for hauling your everyday essentials. Best Features: Highly durable fabric, Comes with 5 Year warranty, Unique design for extra comfort


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Concord, NC (Sports Network) - Matt Kenseth passed Carl Edwards with three
laps remaining and then held off his Roush Fenway Racing teammate to win
Saturday's Top Gear 300 Nationwide Series race at Charlotte Motor Speedway.
Kenseth made his first start in the series this season, substituting for
Trevor Bayne in Roush Fenway's No.16 Ford. Bayne is expected to return to
NASCAR competition next weekend at Chicagoland Speedway.
During a late-race caution, Kenseth pitted from the lead for four new tires,
while Edwards remained on the track and took over the top position. Edwards
last pitted during a round of green-flag pit stops with less than 70 laps to
go in the 200-lap race.
"We had new tires, and I could see [Edwards] fade a little bit at the end of
the run," Kenseth said. "Carl is one of the best out there every Sunday and
Saturday, so when you can beat him at the game, you know you've had a good
Kenseth claimed his 26th career Nationwide win and third at Charlotte.
Edwards conserved enough fuel to cross the finish line 0.8 seconds behind
Kenseth. It was a 1-2 finish for Roush Fenway. Last Saturday, Edwards won the
NASCAR Sprint All-Star Race here.
"I got a little bit tight, but Matt raced me really clean," said Edwards, who
led the most laps with 63. "He was kind of messing with me there a little bit.
I could tell when he needed to go he took off."
Kyle Busch, who was attempting to tie Mark Martin's series record of 49 wins,
finished third.
"We had a really good car there at the beginning and through the middle stages
of the race, but unfortunately, we just weren't fast enough there at the end,"
Busch said. "We just didn't have the speed to stay with those Roush cars
Ricky Stenhouse Jr., the pole sitter, and Reed Sorenson rounded out the top-
five. Stenhouse claimed his first career Nationwide win last Sunday at Iowa
Speedway. He will also make his Sprint Cup Series debut in Sunday's 600-mile
race at Charlotte, driving the No.21 Wood Brothers Racing Ford in place of
Brad Keselowski, Steve Wallace, Brian Scott, Aric Almirola and Elliott Sadler
finished sixth through 10th, respectively.
Sadler holds only a one-point lead over Stenhouse. Sorenson is just two points
behind the leader.
Kimi Raikkonen struggled in his Nationwide debut at Charlotte. Raikkonen was
caught speeding off of pit road and had to serve a pass-through penalty on lap
141. The 2007 Formula One champion had to pit one lap after his penalty when
he ran over a piece of debris on the track, and finished four laps behind in


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Event: DevDroid Meetup August 21
Open Software Integrators is hosting the Triangle Android Developers Group! OSI will be providing pizza, drinks and wifi.
Wednesday, August 21, 2013
Location: (Instructions for parking can be found under Durham office directions)
Open Software Integrators
345 W. Main St. Suite 201
Durham, NC 27701
About the group:
Press Release: Open Software Integrators Wins Alfred P. Sloan Award for Excellence in Workplace Effectiveness & Flexbility
InfoWorld: Java faces tough climb to catch up to .Net
By the time Java 8 comes out, it'll be another two to five years behind .Net -- and Microsoft's coordinated front
Expensify's CEO David Barrett has an accounting problem
It isn't the number of hours you work, but what you accomplish
Expensify's CEO, David Barrett has an accounting problem. He thinks that number of hours worked is a great way to judge work ethic. In fact, his first post started kind of strong, but his follow up degraded into the kind of thing that points at two basic problems: an accounting problem and a project management problem.
Event: Graph Database Durham Un-Meetup
Based on the popular concept of an Un-Conference, we will have lightning talks based on who is doing interesting Graph things and who shows up. Additionally, we will do hands-on mentored 'up and graphing' labs for those aspiring graphistas and pair-graphing for those who want to explore a GraphDB idea.
Come prepared to tell the crowd something interesting about your graph DB goodness!
6:30 - Pizza & Bull City Burger Beer, yum
7:00 - Welcome
InfoWorld: What are graph databases good for? Here's a killer app
Still using an RDBMS for friend-of-a-friend queries? Big mistake. Enlist a graph database using Neo4j instead
Press Release: 10gen And Open Software Integrators Announce Partnership Supporting MongoDB
DURHAM, N.C., July 29, 2013 -- Open Software Integrators, LLC (OSI), the open source professional services company, today announced a partnership with 10gen, the MongoDB company and leading NoSQL database.
InfoWorld: Love and hate for Java 8
Java 8 brings exciting developments, but as with any new technology, you can count on the good, the bad, and the headaches
Thanks to Michael Brush who contributed significantly to this article. -- ACO
InfoWorld: How my company went 100 percent cloud
A drunk driver expedited our cloud migration. Here's how we swapped in-house apps for the cloud equivalents in record time
Last year I wrote about my New Year's resolution to go all-in with the cloud. I expected to do this gradually. Then disaster struck.
Integrating Workflow With Activiti
Authored by: Phil Rhodes, Senior Consultant at Open Software Integrators
"Workflow Engines" or "BPM" systems are quite a trendy topic these days. Everywhere you turn, somebody is talking about BPM, BPMS, or Workflow. So, what is all this stuff? And how can you implement it in your organization with minimal expenditure and up-front risk? These are some of the questions we will examine in this article.


text:
5715 Dartmouth Drive
Northcrest, Fort Wayne, 46825
Commute to Downtown Fort Wayne
Most errands require a car.
A few nearby public transportation options.
Flat as a pancake, minimal bike lanes.
5715 Dartmouth Drive has a Walk Score of 39 out of 100. This location is a Car-Dependent neighborhood so most errands require a car.
This location is in the Northcrest neighborhood in Fort Wayne. The closest park is Johnny Appleseed Memorial Park.
Nearby schools include Bishop Dwenger High School, Northcrest Elementary School and Northrop High School.
The closest grocery stores are Walmart on Coldwater, Oriental Grocery & Mart and JRS Asian Grocery.
Nearby coffee shops include Banh Mi Barista, Starbucks and Chocolate Cafe. Nearby restaurants include House of Hunan, Don Hall's Factory and Jimmy John's Gourmet Sandwiches.
5715 Dartmouth Drive is near Indiana University-Purdue University - Fort Wayne, Katler Park and Shoaff Park.
There are minimal bike lanes and the terrain is flat as a pancake. 5715 Dartmouth Drive is somewhat bikeable, there is minimal bike infrastructure.
Explore how far you can travel by car, bus, bike and foot from 5715 Dartmouth Drive.
5715 Dartmouth Drive has some transit which means a few nearby public transportation options.
Bus lines:
21 Glenbrook / Coldwater / Dupont Road
0.2 mi
1 Northcrest
0.3 mi
1a Colony/Campus
0.3 mi
8 Glenbrook / Northrop
0.3 mi
15 MedLink
0.5 mi
5715 Dartmouth Drive is in the Northcrest neighborhood. Northcrest is the 30th most walkable neighborhood in Fort Wayne with a neighborhood Walk Score of 47.


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Monday, 20 October 2014
Blue jar and Seed Pods
Posted by Cathy Holtom at 16:47 2 comments:
Labels: blue jar, oil painting, seed pod
Thursday, 9 October 2014
|Oil on mdf wood board 20x20 cms/ 8"x8"
You'll find a moka coffee pot in most Italian homes. It's comforting glugs and gurgles signal the start of a new day....but coffee is always a good excuse to stop during the day or get together with a friend.
I love to sit in a bar with a capuccino and watch the world go by, especially if there's a warm croissant involved too!
Could you live without coffee? I know I couldn't !
Posted by Cathy Holtom at 12:12 13 comments:
Labels: moka coffee pot, oil painting
Tuesday, 30 September 2014
Sketching 'La Natura Morta '
Summer is over and the weather is changing. We've had some high winds over the past week and it was one windy night when I heard something patter as it blew into my room while I was asleep.
With no glasses and in the dark I could just make out the shape of a small lizard by my bed.
After a little bit of nudging it wasn't going to move and I realised it was not only dead but perfectly conserved by the hot dry weather. It must have got caught between the window and the blinds.
So what else could I do, I sketched it the next morning. It's still on the sideboard much to my daughter's horror...she says it's looking at her!
Leaves are starting to turn too, this is one I picked up. Autumn is here, my favourite season!
What's your favourite season?
Posted by Cathy Holtom at 15:45 6 comments:
Monday, 15 September 2014
Sketchbook Sunday (on Monday)
I have been getting back to my watercolours this week...sometimes I need to be inspired by a colour or something I see to really enjoy this watery and rebellious medium!
The plums are painted in my favourite colours for painting, I love juicy pinks, reds and purples.
This is a black bumble bee that I found resting on my garden wall. They are not particularly aggressive although they look quite frightening...it was the size of my thumb and very black and shiny.
When you get up close the black becomes a vivid blue in the wings. But I didn't get too near, I'm not that brave....I zoomed in with my camera and took some photos!
Posted by Cathy Holtom at 18:34 10 comments:
Labels: bee, black, plums, purple, watercolour
Sunday, 7 September 2014
The Edge
This is a scene slightly off the footpath through a regal hunting forest from hundreds of years ago. It's a little opening that gives you amazing views over the forest.
On this occasion it's about as far as I got as some cows made an appearance, not that I am afraid of cows....but my friend was! Ok so they were very big with long horns and didn't seem to want us to to go any further, but that's no reason to hide behind a tree?
We had to turn back, cutting short our walk... so now you know what I was thinking about while painting!
40x40 cms, oil on mdf board
Posted by Cathy Holtom at 18:37 6 comments:
Labels: landscape, oil painting, trees
Sunday, 31 August 2014
Sketchbook Sunday
My is sketchbook is always on hand even early in the morning. This simple teabag was such a pretty colour (some kind of flower and fruit mix) that I was tempted to make a little watercolour sketch.
Perhaps I'll have a go painting with the tea next time!
This man was enjoying an 'aperitivo' outside a bar....but the big terracotta vase was in my way. I did think of putting a dog there instead, but I'm not very good at dogs. The big vases should have plants or a bush of some kind but sadly there was only a few weeds and lots of cigarette butt ends.
I've also been practicing some figure drawing using http://artists.pixelovely.com/
A useful site that gives you the choice of many poses, faces, hands and feet.....better than watching TV in the evening!
Here are some more.
Posted by Cathy Holtom at 19:00 8 comments:
Labels: figure drawing, sketchbook, teabag
Sunday, 24 August 2014
Somewhere in the Middle
Living on an island it seems pretty normal to paint the coastline and boats but some of my favourite views are inland. The Sicily I love is somewhere in the middle of nowhere. A road that takes you winding up and over the hills, big wide spaces and endless scenery.
I'm not sure I would find this spot again, but I imagine that in the summer months the hill becomes sandy yellow as the hot sun beats down. Quite a lonely place to live too!
Oil on mdf panel 40x40cms
Posted by Cathy Holtom at 18:14 1 comment:
Labels: landscape, oil painting, sicily
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Staff Picks
Marco Tempest: The electric rise and fall of Nikola TeslaYouTube 2y ago
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'Avengers: Age of Ultron' TrailerHollywoodStreams 12h ago
Taking a spin on a real-life hoverhoardBest of YouTube 12h ago
'Learn How to Behave': Anderson Cooper Shuts Down Selfie-SeekerReddit Video 13h ago
Jimmy Kimmel Surprises Hero Who Saved Man From Burning BuildingJimmy Kimmel Live 13h ago
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Islamic State hit by airstrike near Kobane - dramatic videoTelegraph.co.uk 17h ago
http://www.ted.com Combining projection mapping and a pop-up book, Marco Tempest tells a visually arresting story about Nikola Tesla -- called "the greatest geek who ever lived" -- from his triumphant invention of alternating current to his penniless last days. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes. Featured speakers have included Al Gore on climate change, Philippe Starck on design, Jill Bolte Taylor on observing her own stroke, Nicholas Negroponte on One Laptop per Child, Jane Goodall on chimpanzees, Bill Gates on malaria and mosquitoes, Pattie Maes on the "Sixth Sense" wearable tech, and "Lost" producer JJ Abrams on the allure of mystery. TED stands for Technology, Entertainment, Design, and TEDTalks cover these topics as well as science, business, development and the arts. Closed captions and translated subtitles in a variety of languages are now available on TED.com, at http://www.ted.com/translate If you have questions or comments about this or other TED videos, please go to http://support.ted.com


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Kyrgyzstan announced it will open an embassy in Azerbaijan's capital, Baku. More
The UN High Commissioner for Human Rights has called on the Kyrgyz government "to refrain from passing draft legislation" against sexual minorities. More
The son of former Kyrgyz President Kurmanbek Bakiev has been sentenced in absentia to life imprisonment for embezzling millions of dollars of state funds. More
Kyrgyz authorities say they have detained a political party leader who is suspected of trafficking illegal drugs. More
A group calling itself "Kalys," Kyrgyz for "arbitrator," has disrupted a scheduled performance of the Ukrainian dance group "Kazaky" in Bishkek. More
Radio Free Europe/Radio Liberty © 2014 RFE/RL, Inc. All Rights Reserved.


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Temp Team
The Temp Team is the Newton-Wellesley Hospital temporary staffing pool. Temp Team placements range in length of time from a few days, a week or several months.
Any or all of the following skills are needed: customer service background, telephone/reception, computer skills, organization, filing, medical terminology, Meditech, medical transcription.
Temp Team members may be placed as file clerks, receptionists, secretaries or executive assistants throughout the hospital.
To become a member fill out a:
- Temp Team application
- A Newton-Wellesley Hospital employment application
To find out more about the program, please call the Temp Team Office at 617-243-6048.
Find a Doctor
Find primary care physicians and specialists.
Free Running ClinicJoin us on Tuesday, Oct. 28, from 6:00-8:00 pm in the Shipley Auditorium at Newton-Wellesley Hospital for a free presentation for beginner and intermediate runners. Registration required.
Learn More >
"Top Doctors"Boston Magazine featured Newton-Wellesley Hospital in their annual "Top Doctors" issue as a top community hospital outside of Boston.
Learn More >
US News and World ReportUS News and World Report has ranked Newton-Wellesley Hospital 16th in Massachusetts.
Learn More >


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Beige Odette Ballet Flats
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Ballet flats are on trend, but if you want a classic pair that will last, check out the Odette flat from KORS Michael Kors. Featuring a durable patent leather upper and ideal round toe, the shoe is the epitome of structure and simplicity. Its clean lines create instant versatility, and the subtle stitched panel at the shoe's heel breathes fresh life into pants of any length. Leather upper and Leather sole. Heel measures approximately 0.25". Made in China. Color: natural
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Norman's last stop on his global trot was his home country France. The land of wine, cheese, the Eiffel Tower and art such...
Alltech's solutions for beef consist of natural, nutritional technologies tailored to address challenges impacting modern beef production and profitability, providing farmers an advantage in this competitive marketplace.
Alltech's global efforts to address beef customers' needs include:
Alltech's solutions for beef are designed to:
Beef cattle face many common challenges such as lameness, acidosis, and rumen function.
Learn more about beef cattle challenges [+]
On-farm solutions are a GAME-CHANGER because they were developed with Nutrigenomics research.
Pathway to Profitability
Alltech offers you a pathway to profitability developed by studying how nutritional, environmental and hormonal events influence animals' cells.


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The Leading eBooks Store Online
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The Buena Salud® Guide to arthritis & your life
What many people don't realize about arthritis is that it can result from more than 100 conditions. In The Buena Salud® Guide to Arthritis and Your Life, Dr. Delgado sorts the facts from the fiction. She provides essential help and guidance for people living with arthritis, including life changes to consider, the best online sources for information, and tools to manage the condition and enjoy a healthy life. The book addresses:
- the different types of conditions that can cause arthritis and their respective treatment
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- the best online sources for information in both English and Spanish, and more.
Also available in Spanish: La guía de Buena Salud® sobre la artritis y tu vidaless
HarperCollins; May 2012
144 pages; ISBN 9780062195937
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A couple of key numbers for Archbishop Wood coming into this baseball season were four and five.
Four — as in the number of innings of varsity pitching experience returning;
Five — as in the number of seniors on the roster.
But with a 5-3 overall record thus far, 3-2 in the Philadelphia Catholic League Blue Division, the present is positive and the future is bright for the Vikings.
"I really like our team," Wood coach Jim DiGuiseppe Jr. said. "I think we'll be a team that truly will improve as the year continues. They're a competitive group.
"It's hard to replace the experience we had last year, but the way you replace it is you get 'em out there and they play. Our program is really solid top to bottom. We've got some nice kids who want to work and get better."
"We had a couple of doubts because we graduated so many seniors, " senior pitcher Nick Ellis said. "But we knew that the kids that were now seniors could step up, and we have juniors that can step into spots."
Wood went 15-7 last year, 8-4 in the PCL Blue, falling in the PCL tournament semifinals. The five seniors back are Ellis, shortstop Erik Bowren, outfielder Matt Funk, infielder Matt Mandes and pitcher Dominick McFadden.
"The seniors last year were awesome; they were great leaders," Funk says. "This year we only have five, a lot of young guys, but I think that's kind of working to our strength. This year, as opposed to last year, we're very balanced throughout. Down the lineup we have kids who are going to put the ball in play and make things happen. Could be a lot of small ball, hit-and-run type situations, a lot of team-oriented stuff."
DiGuiseppe notes the Vikings have good team speed. Early in the season it's been clear they can score runs. In four of Wood's wins it has scored in double digits.
The Vikings have a lot of skill and commitment spread across the senior, junior and sophomore classes. Junior catcher Nick Lafferty currently leads the hitters with a .476 average and has nine RBIs. Bowren is batting .407 with 11 RBIs.
McFadden is 3-1 on the mound, posting a sharp 1.78 ERA with 17 strikeouts in 19 innings, and two complete games.
"I don't think it's pressure," McFadden said of the relatively inexperienced pitching staff. "I think there are a lot of guys who are anxious to get out there and throw. People have to step up and get the opportunity."
"We had great leaders last year," Ellis said. "And we try to take a lot of what we learned from them to use this year, since we're so young we need the extra leadership. All of us need to step up and be the best leaders we can."
Game to watch
Wednesday, Neshaminy at Council Rock North, 3:30 — North swept the series last year but Neshaminy won the league crown. The Indians really need this after dropping two early SOL National games. Neshaminy was the lone unbeaten in league play heading into this week, but CR South knocked Neshaminy off Monday 4-2.
"(North is) a great team, they've got a lot of guys back, but I think we'll be ready to come out and play against them," Neshaminy standout Cole Creighton said. "Losing to them twice last year really stunk."
Hit and run
Pitching has been a pleasant surprise for Bristol. Coilean Malone threw four shutout innings against Morrisville; Phil Krause and Danny Padilla combined to allow no earned runs against Christopher Dock … The Truman at Council Rock North game that was postponed April 7 will be played Tuesday at 3:30. Coming off senior trip week, that gave the Indians games three days in a row this week, including Monday at Bensalem and Wednesday vs. Neshaminy … The CR South at Pennsbury game that was suspended in the fifth inning April 7 will resume Tuesday at 3:45 with CR South leading 5-2 … The Falcons host Abington Wednesday at 3:45 and Holy Ghost Prep Thursday morning at 11.
Dan Dunkin: firstname.lastname@example.com; Twitter, @DanDunkin


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D810 Secondary Card Issue...
Started 2 months ago | Discussions thread
D810 Secondary Card Issue...
2 months ago
I set up the secondary slot function [Shooting Menu] to "RAW primary - JPEG secondary". The icon on the Shooting Menu screen confirms the selection. When take a picture and look at the secondary card, it has a NEF file. That file is identical to the one on the primary card as far as I can tell.
I get the same result when I select "Backup" [however, this result is the CORRECT result when "Backup" is chosen].
The cards are [I know somebody will ask, even after I write the following]:
- Sandisk Extreme 16 GB 120 MB/s
- Sandisk Extreme 64 GB SDXC 1
Yes, both those are listed in the Users Manual as approved.
Has anyone else tried the "RAW primary - JPEG secondary" selection and gotten the correct result on the secondary card; ie, a JPEG file?
chuxter's gear list:chuxter's gear list
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Nikon D810
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My sister forwarded me this article about Millie, the rock-climbing/adventure-loving cat.
"Millie has all the qualities a good climbing partner should have. She never complains, no matter how bad it gets. She always wants to go higher, and she pushes herself hard. But she also knows when to stop. When she's done, she's done. She'll find a cave or climb a tree and won't move until she's rested. She takes big risks and doesn't bitch when they don't pan out. And she cuddles at night inside your sleeping bag and keeps you warm. She isn't annoyingly mono-focused on climbing, either. She's happy to explore slot canyons, caves, deserts, fields, etc."
So…Millie is bad-ass, no?
I'm now obsessed with @pechanga's instagram. It's inspiring, adorable, and heart-warming.