text:
Research Topics
Genomes and Genes
malonyl coenzyme a
Summary: A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications168 found, 100 shown here
- AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed ratsMurwarid M Assifi
Diabetes and Metabolism Unit, Boston Univ Medical Center, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 289:E794-800. 2005..They also suggest that the changes in these enzymes, and later occurring increases in enzymes regulating fatty acid and glycerolipid synthesis, could be coordinated by AMPK...
- Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone productionZachary L Fowler
Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, 303 Clifford C Furnas Hall, Buffalo, NY 14260, USA
Appl Environ Microbiol 75:5831-9. 2009..network to predict improved Escherichia coli genotypes that more effectively channel carbon flux toward malonyl coenzyme A (CoA) and other cofactors in an effort to generate recombinant strains with enhanced flavonoid production ..
- Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animalsH James Harwood
Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton Laboratories, Pfizer Inc, Groton, Connecticut 06340, USA
J Biol Chem 278:37099-111. 2003..Taken together, These observations indicate that isozyme-nonselective ACC inhibition has the potential to favorably affect risk factors associated with the metabolic syndrome...
- Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme ANeil B Ruderman
Division of Endocrinology, Boston University Medical Center, Boston, MA 02118, USA
Obesity (Silver Spring) 14:25S-33S. 2006..lipid abnormalities could be a dysregulation of the adenosine monophosphate-activated protein kinase (AMPK)/malonyl coenzyme A (CoA) fuel-sensing and signaling mechanism...
- Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoAMiguel Lopez
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, U K
Diabetes 55:1327-36. 2006..The finding that TMX can modulate appetite through alterations in FAS expression and malonyl-CoA levels suggests a link between hypothalamic sex steroid receptors, fatty acid metabolism, and feeding behavior...
- Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2L Abu-Elheiga
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 291:2613-6. 2001..The mutant mice accumulated 50% less fat in their adipose tissue than did wild-type mice. These results raise the possibility that pharmacological manipulation of ACC2 may lead to loss of body fat in the context of normal caloric intake...
- A novel role of malonyl-ACP in lipid homeostasisMariano A Martinez
Instituto de Biologia Molecular y Celular de Rosario IBR CONICET, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
Biochemistry 49:3161-7. 2010..subtilis is finely regulated at the transcriptional level by sensing the concentrations of the two first intermediates (malonyl-CoA and malonyl-ACP) in order to balance the production of membrane phospholipids...
- Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitorsJie Fei Cheng
Department of Chemistry, Chugai Pharma USA, LLC, 6225 Nancy Ridge Drive, San Diego, California 92121, USA
J Med Chem 49:1517-25. 2006....
- Minireview: malonyl CoA, AMP-activated protein kinase, and adiposityNeil B Ruderman
D Phil, Diabetes Unit, Boston Medical Center, 650 Albany Street, X825, Boston, Massachusetts 02118, USA
Endocrinology 144:5166-71. 2003An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl coenzyme A (CoA) to the regulation of energy balance...
- Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidationJason R B Dyck
Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, 474 Heritage Medical Research Centre, The University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
Circ Res 94:e78-84. 2004..b>Malonyl coenzyme A (CoA) regulates fatty acid oxidation by inhibiting mitochondrial uptake of fatty acids...
- Malonyl-CoA, a key signaling molecule in mammalian cellsDavid Saggerson
Institute of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, WC1E 6BT, Great Britain
Annu Rev Nutr 28:253-72. 2008....
- A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coliJ H An
Department of Biochemistry, College of Science, Bioproducts Research Center, Yonsei University, Seoul, Korea
Eur J Biochem 257:395-402. 1998..trifolii and that the metabolic pathway in the malonate-rich clover nodule might play an important role in symbiosis...
- Regulation of malonyl-CoA concentration and turnover in the normal heartAneta E Reszko
Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
J Biol Chem 279:34298-301. 2004..Our data show that, in the absence of enzyme inhibitors, the rate of acetyl-CoA carboxylation is the main determinant of the malonyl-CoA concentration in the heart...
- Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in miceSharda P Singh
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Biochemistry 47:3900-11. 2008..A., et al. (2007) Mol. Cell. Proteomics 6, 624-637]. The two reciprocal processes are likely to establish a positive feedback loop that would promote and perpetuate the obese state...
- Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscleBlake B Rasmussen
Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
J Clin Invest 110:1687-93. 2002..acids (LCFAs) into the mitochondria via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased malonyl coenzyme A (malonyl-CoA) (a known potent inhibitor of CPT-1) in human muscle during hyperglycemia with hyperinsulinemia...
- Structural basis of lipid biosynthesis regulation in Gram-positive bacteriaGustavo E Schujman
Instituto de Biologia Molecular y Celular de Rosario IBR, Universidad Nacional de Rosario, Rosario, Argentina
EMBO J 25:4074-83. 2006..subtilis, suggesting this homeostatic signaling pathway as a promising target for novel chemotherapeutic agents against Gram-positive pathogens...
- FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesisGustavo E Schujman
Instituto de Biologia Molecular y Celular de Rosario IBR, Departamento de Microbiologia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina
Dev Cell 4:663-72. 2003..Our results indicate that control of FapR by the cellular pools of malonyl-CoA provides a mechanism for sensing the status of fatty acid biosynthesis and to adjust the expression of the fap regulon accordingly...
- Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulationPeter N Bavenholm
Division of Medicine, Departments of Emergency and Cardiovascular Medicine, Karolinska Hospital and Institute, S 17176 Stockholm, Sweden
J Clin Endocrinol Metab 88:82-7. 2003..Likewise, sustained increases in the concentration of malonyl coenzyme A (CoA), an inhibitor of fatty-acid oxidation, have been observed in muscle in association with insulin ..
- Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exerciseCarsten Roepstorff
The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
Am J Physiol Endocrinol Metab 288:E133-42. 2005..They also suggest that, with high muscle glycogen, the availability of free carnitine may limit fat oxidation during exercise, due to its increased use for acetylcarnitine formation...
- Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathyLihong Cheng
Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
Nat Med 10:1245-50. 2004..We suggest that PPAR-delta is a potential therapeutic target in treating lipotoxic cardiomyopathy and other heart diseases...
- AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesityA Janovska
Discipline of Medicine, University of Adelaide, Adelaide, SA 5005, Australia
Mol Cell Endocrinol 284:1-10. 2008..AMPK activation by leptin occurred independently of energy-related metabolites. These data demonstrate that the leptin effect on AMPKalpha and ACCbeta is muscle fibre type dependent and fails in diet-induced obesity...
- In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liverIlya R Bederman
Department of Nutrition and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 279:43217-26. 2004..ISA uses all mass isotopomers, correctly identified imposed gradients of precursor enrichment, and estimated the expected values of fractional synthesis within the constraints of the data...
- gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit heartsArzu Onay-Besikci
Cardiovascular Research Group, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 279:44320-6. 2004..These results suggest that a decrease in plasma insulin and increase in gAd are involved in the increase of cardiac fatty acid oxidation in the immediate newborn period...
- Hypothalamic malonyl-coenzyme A and the control of energy balanceMichael J Wolfgang
Department of Biological Chemistry, Johns Hopkins University School of Medicine, 512 WBSB, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Mol Endocrinol 22:2012-20. 2008....
- Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acidP Degrace
UPRES Lipides et Nutrition EA2422, Faculte des Sciences Gabriel, Universite de Bourgogne, 21000 Dijon, France
J Nutr 134:861-7. 2004..These data indicate that FA oxidation capacities were increased in mice fed CLA2, but were likely depressed in vivo through malonyl-CoA inhibition...
- Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelinMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, S Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
Cell Metab 7:389-99. 2008..Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding...
- AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatmentGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Am J Physiol Endocrinol Metab 284:E648-54. 2003..However, taken as a whole, our data support recent evidence in rodent muscle that leptin stimulates FA oxidation through stimulation of AMPK and a subsequent downregulation of ACC activity...
- Competition between acetate and oleate for the formation of malonyl-CoA and mitochondrial acetyl-CoA in the perfused rat heartFang Bian
Department of Nutrition, Case Western Reserve University, 2109 Adelbert Road, Room BRB923, Cleveland, OH 44106 4906, USA
J Mol Cell Cardiol 41:868-75. 2006..The inhibition by acetate or propionate of acetyl-CoA production from oleate probably results from a competition for mitochondrial CoA between the CoA-utilizing enzymes...
- Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cellsGianfranco Peluso
National Cancer Institute INT Fondazione G Pascale, Via Mariano Semmola, 80131 Naples, Italy
J Cell Physiol 203:439-46. 2005....
- AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contractionMarcella A Raney
Dept of Kinesiology and Biological Sciences, Diabetes Research Center, Univ of Southern California, 3560 Watt Way, PED 107, Los Angeles, CA 90089 0652, USA
Am J Physiol Endocrinol Metab 288:E592-8. 2005..These results suggest that while AMPK-dependent mechanisms may regulate FA uptake and FA oxidation at rest, AMPK-independent mechanisms predominate during low-intensity muscle contraction...
- LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscleD M Thomson
Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
Am J Physiol Endocrinol Metab 293:E1572-9. 2007..Regardless, our results suggest that LKB1 is an important regulator of malonyl-CoA levels and fatty acid oxidation in skeletal muscle...
- Pulling in more fatDavid E Kelley
Department of Medicine, University of Pittsburgh Medical Center, Montefiore Hospital, Pittsburgh, Pennsylvania 15213, USA
Cell Metab 2:275-6. 2005..In obesity, skeletal muscle accumulates triglyceride. Recent work from Hulver and colleagues (2005) in the October issue of Cell Metabolism implicates stearoyl-CoA desaturase as part of the underlying molecular mechanism...
- Malonyl CoA control of fatty acid oxidation in the newborn heart in response to increased fatty acid supplyArzu Onay-Besikci
Department of Pharmacology, Faculty of Pharmacy, Ankara University, Turkey
Can J Physiol Pharmacol 84:1215-22. 2006..Our results suggest that the regulatory role of malonyl CoA remained when the hearts were exposed to high levels of fatty acids...
- Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exerciseGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
J Physiol 571:201-10. 2006..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
- The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasisMichael J Wolfgang
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 103:7282-7. 2006..CPT1c KO mice also exhibit decreased rates of fatty acid oxidation, which may contribute to their increased susceptibility to diet-induced obesity. These findings indicate that CPT1c is necessary for the regulation of energy homeostasis...
- Expression of genes regulating malonyl-CoA in human skeletal muscleCelia Pender
Department of Medicine, Diabetes and Endocrine Research, Mount Zion Medical Center, University of California, San Francisco, California 94143 1616, USA
J Cell Biochem 99:860-7. 2006..No other genes showed signs of increased mRNA content with obesity, suggesting that there may be selective transcriptional regulation of malonyl-CoA metabolism in human obesity...
- Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defectsGautam K Bandyopadhyay
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, 9500 Gilman Dr, La Jolla, 92093, USA
Diabetes 55:2277-85. 2006....
- Role of malonyl-CoA in heart disease and the hypothalamic control of obesityClifford D L Folmes
Cardiovascular Research Group, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
Cardiovasc Res 73:278-87. 2007..Targeting enzymes that control malonyl-CoA levels may be an important therapeutic approach to treating heart disease and obesity...
- Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicityWen Guo
Evans Department of Medicine, Obesity Research Center, Boston University Medical Center, 88 E Newton St, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 292:E1041-51. 2007..Thus preadipocyte fatty acid handling changes with aging, with increased susceptibly to lipotoxicity and impaired fatty acid-induced adipogenesis and beta-oxidation...
- Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscleSeung Hun Cha
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:14557-62. 2005..These findings clarify the mechanism by which the hypothalamic malonyl-CoA signal is communicated to metabolic systems in skeletal muscle that regulate fatty acid oxidation and energy expenditure...
- Regulation of hypothalamic malonyl-CoA by central glucose and leptinMichael J Wolfgang
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:19285-90. 2007..These studies show that hypothalamic malonyl-CoA responds to the level of circulating glucose and leptin, both of which affect energy homeostasis...
- The role of the carnitine system in human metabolismDaniel W Foster
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9030, USA
Ann N Y Acad Sci 1033:1-16. 2004..Activation of fatty acid oxidation has considerable clinical promise for the treatment of obesity, type 2 diabetes, steatohepatitis, and lipotoxic damage to the heart...
- Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicityA G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Int J Obes Relat Metab Disord 28:S29-37. 2004....
- Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesisJavier A Menendez
Department of Medicine, Evanston Northwestern Healthcare Research Institute, 1001 Unviersity Place, Evanston, IL 60201, USA
Med Hypotheses 64:337-41. 2005....
- Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolismTimothy R Koves
Department of Physiology, Brody School of Medicine, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Am J Physiol Cell Physiol 288:C1074-82. 2005..These results demonstrate that endurance exercise provokes subpopulation-specific changes in mitochondrial function that are characterized by enhanced fatty acid oxidation and modified CPT1beta-malonyl-CoA dynamics...
- Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic ratVijay Sharma
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Univ of British Columbia, Vancouver, Canada
Am J Physiol Heart Circ Physiol 294:H1609-20. 2008..The metabolism changes occur in parallel with changes in gene expression...
- Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated miceAnna Planavila
Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Spain
Biochem Pharmacol 69:1195-204. 2005..These findings implicate ceramide as an important intermediate in the regulation of Akt after troglitazone treatment...
- Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac powerKristen L King
Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
Am J Physiol Heart Circ Physiol 289:H1033-7. 2005....
- Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidationLufang Zhou
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
Am J Physiol Heart Circ Physiol 294:H954-60. 2008....
- Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout miceSusanne Neschen
Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, CN 06520, USA
Cell Metab 2:55-65. 2005..These data suggest that mtGPAT1 might serve as a novel target for treatment of hepatic steatosis and hepatic insulin resistance and that long chain acyl-CoA's do not mediate fat-induced hepatic insulin resistance in this model...
- Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intakeMiguel Lopez
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Bioessays 29:248-61. 2007..Understanding these molecular mechanisms could provide new targets for the treatment of obesity and related disorders...
- Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptakeAlice J Yee
Department of Kinesiology, University of Southern California, Los Angeles, California 90089, USA
Am J Physiol Endocrinol Metab 283:E73-7. 2002....
- C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesityJagan N Thupari
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 99:9498-502. 2002..The dual action of the C75 class of compounds as fatty acid synthase inhibitors and CPT-1 agonists has therapeutic implications in the treatment of obesity and type II diabetes...
- Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axisLaura L Atkinson
Cardiovascular Research Group, Muttart Diabetes Research and Training Center, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 277:29424-30. 2002..These data demonstrate for the first time that leptin activates fatty acid oxidation and decreases TG content in the heart. We also show that the effects of leptin in the heart are independent of changes in the AMPK-ACC-malonyl-CoA axis...
- Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cellsH Mulder
Touchstone Center for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 276:6479-84. 2001..These findings extend our previous observations and are not consistent with the LC-CoA hypothesis as originally set forth...
- Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscleJong Yeon Kim
Department of Biochemistry, East Carolina University, Greenville, North Carolina 27858, USA
Am J Physiol Endocrinol Metab 282:E1014-22. 2002..These results provide evidence of a malonyl-CoA-insensitive CPT I activity in red muscle, suggesting fiber type-specific expression of distinct CPT I isoforms and/or posttranslational modulations that have yet to be elucidated...
- Alteration of hepatic fatty acid metabolism after burn injury in pigsW Z Martini
Shriners Burns Hospital and the Department of Surgery, The University of Texas Medical Branch, Galveston 77550, USA
JPEN J Parenter Enteral Nutr 25:310-6. 2001..05). CONCLUSIONS: The accumulation of hepatic TG in burned animals is due to inhibition of VLDL-TG secretion and to increased synthesis of hepatic TG. Fatty acids are not channeled to TG because of impaired oxidation...
- Regulation of myocardial fatty acid oxidation by substrate supplyS L Longnus
McDonald Research Laboratories/iCAPTURE Centre, Department of Pathology and Laboratory Medicine, University of British Columbia and St. Paul's Hospital/Providence Health Care, Vancouver, British Columbia V6Z 1Y6, Canada
Am J Physiol Heart Circ Physiol 281:H1561-7. 2001..More extreme variations in substrate supply lead to changes in fatty acid oxidation by the additional involvement of intracellular regulatory pathways...
- Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicityJ N Thupari
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Biochem Biophys Res Commun 285:217-23. 2001..This study identifies CPT-1 and ACC as two new potential targets for cancer chemotherapy...
- Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cellsZ Dagher
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Circ Res 88:1276-82. 2001..in palmitate oxidation during a 2-hour incubation are associated with a decrease in the concentration of malonyl coenzyme A (CoA) (an inhibitor of carnitine palmitoyl transferase 1), which temporally parallels the increase in AMPK ..
- Cell signaling. A new way to burn fatJaap G Neels
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0673, USA
Science 312:1756-8. 2006
- An increase in peroxisomal fatty acid oxidation is not sufficient to prevent tissue lipid accumulation in hHTg ratsJ Ukropec
Diabetes and Nutrition Research Laboratory, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
Ann N Y Acad Sci 967:71-9. 2002....
- tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1A Giordano
Institute of Protein Biochemistry IBP, CNR, Naples, Italy
Cell Death Differ 12:603-13. 2005....
- Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificityGalina Florova
Department for Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23219, USA
Biochemistry 41:10462-71. 2002..In contrast, the ACP specificity of FabH, isotope labeling studies, and a demonstrated alternative mechanism for initiation of the PKS process provide unequivocal evidence that FabH is involved only in the FAS process...
- Malonyl CoA control of fatty acid oxidation in the ischemic heartJason R B Dyck
Cardiovascular Research Group, Departments of Pediatrics and Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Mol Cell Cardiol 34:1099-109. 2002..This paper will discuss some of the molecular changes that occur in fatty acid oxidation in the ischemic heart and will include a discussion of the important role of malonyl CoA in this process...
- cDNA cloning, heterologous expressions, and functional characterization of malonyl-coenzyme a:anthocyanidin 3-o-glucoside-6"-o-malonyltransferase from dahlia flowersHirokazu Suzuki
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Aoba yama 07, Sendai 980 8579, Japan
Plant Physiol 130:2142-51. 2002..Moreover, 6"-O-malonylation of cyanidin 3-O-glucoside effectively prevented the anthocyanin from attack of beta-glucosidase. These results suggest that malonylation should serve as a strategy for pigment stabilization in the flowers...
- Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesisR G Summers
Department of Bacteriology, University of Wisconsin, Madison 53706, USA
Biochemistry 34:9389-402. 1995..This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium...
- Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovBSuzanne M Ma
Department of Chemical and Biomolecular Engineering, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA
FEBS J 274:2854-64. 2007..The KS domain displayed no activity towards acetyl groups, but was able to recognize malonyl groups in the absence of cerulenin. The relevance of these finding to the priming mechanism of fungal polyketide synthase is discussed...
- Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acid synthase acyl carrier proteinW P Revill
John Innes Centre, Norwich Research Park, Colney, United Kingdom
J Bacteriol 178:5660-7. 1996..coelicolor FAS, malonyl coenzyme A:ACP acyl-transferase. Expression of S...
- An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolorYinhua Lu
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, People s Republic of China
J Bacteriol 193:3020-32. 2011..the increased production of ACT and RED in the mutant could be partly ascribed to the enhanced precursor malonyl coenzyme A (malonyl-CoA) supply through increased transcription of genes encoding acetyl-CoA carboxylase (ACCase)...
- Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD)A J Kutchma
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
J Bacteriol 181:5498-504. 1999..In an in vitro system, purified ACP functioned as acyl acceptor and H(6)-FabD exhibited malonyl-CoA:ACP transacylase activity...
- High-resolution structure of ybfF from Escherichia coli K12: a unique substrate-binding crevice generated by domain arrangementSuk Youl Park
Department of Chemistry and Institute of Basic Sciences, Chonnam National University, 300 Yongbong Dong, Buk Gu, Gwangju 500 757, Korea
J Mol Biol 376:1426-37. 2008..Escherichia coli (Ec_ybfF) belongs to the esterase family for the large substrates, palmitoyl coenzyme A and malonyl coenzyme A, which are important cellular intermediates for energy conversion and biomolecular synthesis...
- Role for malonyl coenzyme A:acyl carrier protein transacylase (MCAT) in the growth-inhibitory effect of the calmodulin antagonist trifluoperazine in Mycobacterium bovis BCGIndrajit Sinha
Mycobacterium Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore
J Antimicrob Chemother 53:1072-5. 2004To determine whether the fatty acid synthesis enzyme malonyl coenzyme A:acyl carrier protein transacylase (MCAT) is involved in the growth-inhibitory effect of trifluoperazine in the tubercle bacillus Mycobacterium bovis BCG.
- Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthaseShane R Wesener
Department of Biological Sciences, University of Wisconsin Milwaukee, P O Box 413, Milwaukee, WI 53201, USA
Appl Environ Microbiol 77:1501-7. 2011..pathway in Escherichia coli cells, two essential genes, fabD1 and fabD2, both encoding a putative malonyl coenzyme A (CoA) acyltransferase component of the fatty acid synthase complex, are positively identified to be involved ..
- Domain analysis of fatty acid synthase protein (NP_217040) from Mycobacterium tuberculosis H37Rv--a bioinformatics studyK V Ramesh
Center for Postgraduate Studies, Sri Bhagawan Mahaveer Jain College, 18 3, 9th Main, Jayanagar 3rd Block, Bangalore 560 011, India
J Biomol Struct Dyn 24:393-412. 2007..Accuracy of the prediction of 3D structure of different domains of FAS protein was further validated by Ramachandran plot and PROCHECK (G-value)...
- Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier proteinChristopher J Arthur
School of Chemistry, University of Bristol, Cantock s Close, Bristol BS8 1TS, UK
ACS Chem Biol 4:625-36. 2009Malonylation of an acyl carrier protein (ACP) by malonyl Coenzyme A-ACP transacylase (MCAT) is fundamental to bacterial fatty acid biosynthesis...
- Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sexMaria Notarnicola
Laboratory of Biochemistry, National Institute for Digestive Diseases S de Bellis, Castellana Grotte, Italy
Oncology 71:327-32. 2006Fatty acid synthase (FAS) is a multienzyme protein required for the conversion of acetyl coenzyme A and malonyl coenzyme A to palpitate...
- Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in SulfolobalesDaniel Kockelkorn
Mikrobiologie, Fakultat Biologie, Schänzlestr 1, D 79104 Freiburg, Germany
J Bacteriol 191:6352-62. 2009..Only distantly related genes were found in the genomes of autotrophic marine Crenarchaeota that may use a similar cycle in autotrophic carbon fixation...
- Synthesis of a putative substrate for malonyl-coenzyme A: 21-hydroxypregnane 21-O-malonyltransferase and development of an HPLC method for the quantification of the enzyme reactionSerge Philibert Kuate
Department of Biology, Friedrich Alexander University of Erlangen Nuremberg, Staudtstr 5, D 91058 Erlangen, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 860:195-201. 2007..The method was validated...
- System analysis of an Arabidopsis mutant altered in de novo fatty acid synthesis reveals diverse changes in seed composition and metabolismMingjie Chen
Interdisciplinary Plant Group and Division of Biochemistry, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
Plant Physiol 150:27-41. 2009..Induction of storage proteins reveals that oil and protein synthesis share carbon intermediate(s) and that reducing malonyl-coenzyme A flow into fatty acids diverts carbon into amino acid and protein synthesis...
- Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscleKarim Bouzakri
Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Diabetes 57:1508-16. 2008b>Malonyl coenzyme A (CoA) decarboxylase (MCD) is a key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism...
- Carbon flux and fatty acid synthesis in plantsStephen Rawsthorne
Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Colney, NR4 7UH, Norwich, UK
Prog Lipid Res 41:182-96. 2002..Examples of such aspects and future opportunities for our understanding of plant fatty acid synthesis are presented and discussed...
- The adrenergic-fatty acid load in heart failureLionel H Opie
Hatter Cardiovascular Research Institute, Department of Medicine, University of Cape Town, South Africa
J Am Coll Cardiol 54:1637-46. 2009..Other future therapies may include malonyl-coenzyme A regulators to inhibit fatty acid oxidation, fish oil omega-3, and activators of protein kinase C-epsilon...
- Glycogen storage disease type 1: impact of medium-chain triglycerides on metabolic control and growthAnibh M Das
Department of Paediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany das anibh mh hannover de
Ann Nutr Metab 56:225-32. 2010..Increased malonyl coenzyme A production which compromises oxidation of long-chain fatty acids via carnitine palmitoyltransferase (CPT) 1 ..
- Purification and characterization of the Mycobacterium tuberculosis FabD2, a novel malonyl-CoA:AcpM transacylase of fatty acid synthaseYi Shu Huang
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China
Protein Expr Purif 45:393-9. 2006b>Malonyl coenzyme A (CoA)-acyl carrier protein (ACP) transacylase (MCAT) is an essential enzyme in fatty acid and mycolic acid biosynthesis of Mycobacterium tuberculosis. fabd2 is a novel gene coding MCAT in M...
- Identification of active-site residues in Bradyrhizobium japonicum malonyl-coenzyme A synthetaseH M Koo
Department of Biochemistry, College of Science, Bioproducts Research Center, Yonsei University, Seoul, Korea
Arch Biochem Biophys 378:167-74. 2000..The kinetic data measured for the mutants suggest that Lys175 and His211 participate in the formation of malonyl-AMP, whereas Glu308 may play a role in malonate binding...
- Apparent growth phase-dependent phosphorylation of malonyl coenzyme A:acyl carrier protein transacylase (MCAT), a major fatty acid synthase II component in Mycobacterium bovis BCGIndrajit Sinha
Mycobacterium Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
FEMS Microbiol Lett 227:141-7. 2003..protein was purified via two-dimensional gel electrophoresis and identified via mass spectrometry to be malonyl coenzyme A:acyl carrier protein transacylase (MCAT), a component of the fatty acid biosynthetic pathway...
- Vitamin B12: unique metalorganic compounds and the most complex vitaminsLucio Randaccio
Centre of Excellence in Biocrystallography, Department of Chemical Sciences, University of Trieste, Via L Giorgieri 1, 34127 Trieste, Italy
Molecules 15:3228-59. 2010..Specifically, functionalized bioconjugates are used as "Trojan horses" to carry into the cell the appropriate antitumour or diagnostic label. Possible future developments of B(12) work are summarized...
- [Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponectin-free fatty acid pathway]Hong Shan Li
Institute of Liver Diseases of Shuguang Hospital, Key Laboratory for Liver Kidney Disease Pattern of Ministry of Education, E Institute of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Zhong Xi Yi Jie He Xue Bao 7:546-51. 2009..To explore the effects of Qushi Huayu Decoction (QSHYD), a compound traditional Chinese herbal medicine, in prevention and treatment of non-alcoholic fatty liver disease (NAFLD) in rats...
- Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat dietWendy Keung
Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
J Cardiovasc Pharmacol 57:103-13. 2011..In high-fat-fed mice, leptin increased cardiac malonyl coenzyme A levels, secondary to a decrease in malonyl coenzyme A decarboxylase expression...
- Role of hypothalamic AMP-kinase in food intake regulationYasuhiko Minokoshi
Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, Aichi, Japan
Nutrition 24:786-90. 2008..Thus, these results suggest that food intake and nutrient metabolism are coordinately regulated by the common signaling pathway of AMPK in the hypothalamus...
- An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230L Han
Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
Microbiology 146:903-10. 2000..It is concluded that jadJ supplies malonyl-coenzyme A for biosynthesis of the polyketide intermediate that is eventually processed to form the antibiotic jadomycin B...
- Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injuryJason R B Dyck
Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2
Circulation 114:1721-8. 2006Acute pharmacological inhibition of cardiac malonyl coenzyme A decarboxylase (MCD) protects the heart from ischemic damage by inhibiting fatty acid oxidation and stimulating glucose oxidation...
- The crystal structure of MCAT from Mycobacterium tuberculosis reveals three new catalytic modelsZexuan Li
Tsinghua Nankai IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084, China
J Mol Biol 371:1075-83. 2007The malonyl coenzyme A (CoA)-acyl carrier protein (ACP) transacylase (MCAT) plays a key role in cell wall biosynthesis in Mycobacterium tuberculosis and other bacteria. The M...
- 3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitorsMaulik R Patel
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
Bioorg Med Chem 15:4470-81. 2007..718 and 0.725, respectively. The information obtained from CoMFA and CoMSIA 3D contour maps may be of utility in the design of more potent MCD inhibitors...
- Regulation of fatty acid oxidation in skeletal muscleB B Rasmussen
Metabolism Unit, Shriners Burns Institute, Texas, USA
Annu Rev Nutr 19:463-84. 1999..Nonetheless, the rate of glucose or glycogen metabolism is probably the primary regulator of the balance between glucose and fatty acid oxidation in muscle...
- A Zea mays GTP-binding protein of the ARF family complements an Escherichia coli mutant with a temperature-sensitive malonyl-coenzyme A:acyl carrier protein transacylaseI I Verwoert
Department of Genetics, BioCentrum Amsterdam, Vrije Universiteit, Netherlands
Plant Mol Biol 27:629-33. 1995..Complementation of a mutation affecting bacterial membrane lipid biosynthesis by a plant ARF protein, could indicate the existence of as yet unidentified bacterial equivalents of this ubiquitous eucaryotic GTP-binding protein...
- Cloning and mutational analysis of human malonyl-coenzyme A decarboxylaseJ Gao
The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
J Lipid Res 40:178-82. 1999b>Malonyl coenzyme A (CoA) decarboxylase (E.C.4. 1.1.9) catalyzes the conversion of malonyl CoA to acetyl CoA...
- Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertensionGopinath Sutendra
Pulmonary Hypertension Program, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
Sci Transl Med 2:44ra58. 2010....
- Molecular characterization of an Escherichia coli mutant with a temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylaseI I Verwoert
Department of Genetics, BioCentrum Amsterdam, Vrije Universiteit, The Netherlands
FEBS Lett 348:311-6. 1994..Site-directed mutagenesis of codon 257 revealed a requirement for an aromatic amino acid at this position in the polypeptide chain, to assure temperature stability of the enzyme...
- Cloning and nucleotide sequence of the fabD gene encoding malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coliK Magnuson
Department of Microbiology, University of Illinois, Urbana 61801
FEBS Lett 299:262-6. 1992We report the cloning and nucleotide sequence of the gene encoding malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli. Malonyl transacylase has been overexpressed 155-fold compared to a wild-type strain...
Research Grants90
- HORMONAL CONTROL OF ADIPOSE GENE EXPRESSIONM Lane; Fiscal Year: 1993..We have obtained compelling evidence that C/EBPalpha serves an essential role in the coordinate activation of a group of adipose-specific genes during adipose conversion...
- FUNGAL POLYKETIDE SYNTHASESCHARLES SIH; Fiscal Year: 2001....
- Antiadipogenic Influence of HIV Protease InhibitorsM Lane; Fiscal Year: 2005..The long term objective of the proposed research is to facilitate the design of anti-HIV therapeutics that lack lipoatrophic potential. ..
- INSULIN AND ADIPOSE CONVERSIONM Lane; Fiscal Year: 1991..e. whether by altering gene transcription or by altering the rate of specific mRNA turnover. The molecular mechanisms by which this regulation is exerted will be investigated...
- HORMONAL CONTROL OF ADIPOSE GENE EXPRESSIONM Lane; Fiscal Year: 2002..g., the Myc/Zif and Sp1 sites) that regulate the C/EBPalpha gene. how C/EBPalpha (and adipocyte genes it controls) is hormonally regulated in the differentiated adipocyte notably in insulin and cAMP. ..
- REGULATION OF LIPOGENESISM Lane; Fiscal Year: 2001..for derepression and repression of the SCD1 and SCD2 genes. ..
- HORMONAL CONTROL OF ADIPOSE GENE EXPRESSIONM Lane; Fiscal Year: 2007..The 32kDa CUP/AP-2alpha- interacting protein, p32, previously identified in our lab, will be characterized and its role determined. ..
- FACTORS AND GENES RESPONSIBLE FOR ADIPOCYTE COMMITMENTM Lane; Fiscal Year: 2006..abstract_text> ..
- REGULATION OF LIPOGENESIS AND VLDL SYNTHESIS/ASSEMBLYM Lane; Fiscal Year: 1993..Positive feed-forward" control will also be investigated. * the molecular basis for tissue-specific expression and regulation of the SCD1 and SCD2 genes...
- CARNITINE PALMITOYLTRANSFERASE AND FATTY ACID METABOLISMDaniel Foster; Fiscal Year: 2002....
- CARNITINE PALMITOYLTRANSFERASE AND FATTY ACID METABOLISMDaniel Foster; Fiscal Year: 1990..In addition, the information gained could lead to diagnostic, and possibly therapeutic, advances in the arena of disease states characterized by excessive or inadequate rates of fatty acid oxidation...
- The role of cardiolipin apoptosisDIANE HICKSON BICK; Fiscal Year: 2007..The role of these modified phospholipids in cyt c release will be determined. We will answer the question "is the loss of cyt c preceded by deacylation of CL?" ..
- Effects of ethanol on AMP kinase signalingDavid Crabb; Fiscal Year: 2007..It may also shed light on the pathogenesis of non-alcoholic fatty liver disease. ..
- MECHANISMS OF ACTIONS OF ALCOHOL AND OMEGA3 FATTY ACIDSRaj Lakshman; Fiscal Year: 1999..the mechanism of inhibition of hepatic sialyltransferase activity? Specifically, does ethanol inhibit the synthesis of sialyltransferase and by down regulation of its hepatic mRNA levels? ..
- Convergence of Nuclear Receptor and Forkhead SignalingPaul Dowell; Fiscal Year: 2004..The excellent research environment at Johns Hopkins coupled with an extensive collaborative team of experts in relevant fields of study is ideal for successful completion of the proposed work. ..
- Estrogens and Insulin Resistance in WomenJerrold Olefsky; Fiscal Year: 2006..abstract_text> ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJerrold Olefsky; Fiscal Year: 2007..abstract_text> ..
- Regulation of Mammalian Oocyte MaturationStephen Downs; Fiscal Year: 2007..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
- Roles of Lipoate Pathways in Plasmodium SurvivalSEAN PRIGGE; Fiscal Year: 2007..falciparum fatty acid biosynthesis. ..
- PHYSIOLOGY OF MALONYL COA IN MUSCLE DURING EXERCISEWILLIAM WINDER; Fiscal Year: 1993..This information will be important for better understanding the metabolic derangements of diabetes mellitus and for understanding regulation of fat utilization during exercise...
- PHYSIOLOGY OF MALONYL COA IN MUSCLE DURING EXERCISEWILLIAM WINDER; Fiscal Year: 2001..These studies will contribute to our understanding of the mechanisms responsible for increasing fat utilization during exercise. ..
- Estrogen Effects in Insulin Target and Granulosa CellsJerrold Olefsky; Fiscal Year: 2004..These studies should also highlight the role of inflammatory pathway activation in these pathophysiologic events and this may have potential therapeutic implications for new treatment approaches. ..
- FATTY ACID METABOLISM IN CARDIAC ISCHEMIADIANE HICKSON BICK; Fiscal Year: 2002..Location of a malonyl-CoA compartment that is inaccessible to CPT-I will shed light on the inconsistency between the high malonyl CoA content in heart and reliance on beta-oxidation. ..


text:
Routes Sorted
L to R R to L Alpha
This classic line shares the first bolt with Try To Be Hip (5.12a) and then soars straight up to a roof with a bolt. Before clipping the bolt at the roof with a 2' runner you must make difficult moves with microstoppers below you. Another crux is encountered after a short traverse right around the roof to a fixed piton. Finish up and right to anchors.
Mostly very small to medium stoppers are essential for protection. Very small to medium cams supplement the stopper placements. Rappel from anchors with webbing.

subset: commoncrawl


text:
Hello all, I have a 66 el camino with a 454 and hei ignition. Car runs great but once hot and shut off it will not restart. Will crank, good fuel pressure just no spark.Best I can tell, is if the tach wire is disconnected from the cap, she will fire,or if left to cool down will fire?What could,go wrong internally with the tach? FYI, it is a 5" monsterThank you in advance.Spec, not that it matters lol, 66 elk custom, 454, turbo 400 with manual shift bodies, 12 bolt posi, front disk, full tube suspention.
seems you have actually answered your own question... does it die while driving with the TACH disconnected??the red wire is the BAT...the white wire is the TACH.but if you notice.. the white wire is also attached to the harness that goes down to the module C terminalthe red wire goes down to the B+ terminal on the module.. the center wire of the 3 going to the module is a ground for the black wire coming out of the coil.. this is the spark return path. so... if the engine dies with the tach connected and does NOT die when the TACH is not connected.. then its more than likely a MONSTER TACH issue.. or the wiring between the HEI tach terminal and the monster tach is shorting out.. if the engine still dies with the TACH disconnected.. then we have to go farther.. remove the coil cover off the top of the cap... stick a test light probe (pointed end) into one of the cavities for the red wire to the coil... be sure that you are not touching the center wire or the white wire...(sometimes yellow ) ground the clip end of the test light to the engine...from the drivers seat.. turn the ignition key from the OFF position .. to the ON position .. then crank the engine .. and release the key back to the RUN position.. then turn it off.. depending on how you have wired the HEI...you should have constant power as soon as the key reaches the ON position.. thru cranking and back to the on position.. if the light is medium brightness and then gets full brightness when you are cranking.. then goes to medium brightness in the on position.. then you are going to need to either use a relay or change your ignition switch to one that does not break contact with the IGN 1 circuit while cranking.. and remove the resistor wire.. replacing it with something slightly thicker.this is something i worked up for in dash ignitions on GMs.. using parts store parts... this does require some slight rewiring .. but nothing major league.. there are a few more tests for the HEI... if the module is not screwed down on a proper layer of dielectric tune up grease... it will over heat and fail.. dielectric tune up grease a thermal compound.. it allows the massive amount of heat created by the switching of the C terminal on the module to the ground .. when the C terminal and the white wire are grounded . the current is flowing thru the primary windings of the coil... when the module breaks the ground connection.. the magnetic field created collapses thru the secondary windings and creates a high voltage spark.. on a V8.. the module makes and breaks this connection 4 times per revolution of the crank..


text:
The Beatles' Early Hits in 1964 The Tribute at ShoWare Center
* Additional fees apply.
All offers for The Beatles Tribute 1964 The Tribute have expired.
The last date listed for The Beatles Tribute 1964 The Tribute was Friday June 28, 2013 / 8:00pm.
Most Popular Music Event Nearby:
French Guitarist Marc Antoine Headlines Outdoor Summer Smooth Jazz Concert
- Full Price:
- $45.00 - $65.00
- Our Price:
A world-renowned French guitarist, a funky Portland saxophonist and a soulful northwest singer-songwriter walk into a casino... This is no joke but the very real and exciting lineup at the third-annual Smooth in Seattle outdoor summer jazz concert at Clearwater Casino & Resort. Paris-born Marc Antoine, whose guitar work has backed the likes of Sting, Rod Stewart and Cher, headlines the event, filling Clearwater's grassy lawn with his intricate multicultural urban groove. But first, saxophonist Patrick Lamb will play his signature magnetic fusion of R&B and rural southern roadhouse, and sweet-voiced Tacoma, Washington singer Stephanie Anne Johnson will open the show. Easy travel options are available from Seattle, including a free shuttle running from the ferry terminal. Food and drinks will be available for purchase at the event Learn More
Venue Details
Park was great. Did not have to walk far at all.The Harlem Globetrotters info • Feb 23 2013 star this tip starred
Very casualThe Harlem Globetrotters info • Feb 23 2013 star this tip starred


text:
In English
Radio Helsinki
You arrived here at 09:55 Helsinki time Tuesday 2.9.2014
H1N1 vaccinations suspended over narcolepsy scare
At least 15 cases of narcolepsy among children and young people in past six months
print this
The possibility of compensations for children and young people diagnosed with narcolepsy recently is to be assessed later if a link between the disease and the swine flu vaccine is established, says Minister of Social Services
Paula Risikko
(Nat. Coalition Party).
"The matter must be evaluated when all studies have been made. Experts insist that if the illnesses and the vaccinations have a connection, we will find out."
"I understand the pain of the families and the seriousness of the situation, but it is too early to take a stand on who has responsibility to compensate."
The National Institute for Health
and Welfare (THL) decided on Tuesday to recommend that vaccinations against swine flu with the
vaccine should be suspended until it is established whether or not the vaccine is the cause of the surge in cases of narcolepsy among children and young people.
By Tuesday, 15 new cases of the disease, which causes the sufferer to suddenly fall asleep without warning, had been diagnosed among children aged 5 to 16 since December. There is a clear time correlation between the cases and the swine flu vaccinations.
In addition to the confirmed cases, there are some where the disease is suspected are being studied.
Normally about six cases
of narcolepsy among children and young people are diagnosed each year in Finland.
An unusually large number of patients have also been diagnosed with narcolepsy in Sweden after vaccinations for swine flu had been administered. There is no information of new cases in other countries.
Suspending the vaccinations
is a precaution, says
Pekka Puska
, director-general of THL. He says that the suspension will continue until the matter has been sufficiently investigated.
Risikko is confident that health care officials and vaccine experts will be able to determine if it will be possible to administer vaccines against swine flu alongside the regular seasonal flu shots.
She herself is confident that the vaccines are safe. "When a pandemic is happening, fast decisions must be made. In a pandemic situation, it is never possible to undertake lengthy research, because this would require thousands of tests, and the examination of thousands of test subjects."
THL emphasises
that there can be many reasons behind the increase in narcolepsy: the swine flu, the vaccine, or an interaction of the vaccine and an infection.
Marjo Renko
, chairwoman of the national group of experts on vaccines, said in a television news interview on Tuesday that the a substance contained in the vaccine is suspected as a possible cause of the narcolepsy. Later Renko said that the matter was out of context. "There is no proof that the increase in narcolepsy would be linked with the vaccines. We do not suspect anything. This is mere speculation."
Previously in HS International Edition:
Finland still has millions of doses of swine flu vaccine (16.8.2010)
Health officials say WHO pandemic pronouncement does not alter Finland´s preparations for swine flu (12.6.2009)
Swine flu shots found to cause mild symptoms of disease (22.10.2009)
Helsingin Sanomat
H1N1 vaccinations suspended over narcolepsy scare
Teaching of Russian is increasing in schools in Eastern Finland
Use of cannabis increases among young Finns
Security Police getting more money for Africa operation
Finnish peacekeeper accidentally wounded on base in Afghanistan
Prime Minister Kiviniemi: EU should reject preaching over human rights
Somali immigrants in Finland agonising over events in their former home country
Nokia and Intel to develop next-generation user interface in Oulu
Back to Top ^


text:
People enjoying this long holiday weekend flocked to the reservoir with food and beverages to enjoy the sunny weather.
But it appears some of the reservoir goers got the message from reservoir officials of "Pack It in, Pack It Out".
Over the Memorial Day weekend several areas of the reservoir were overrun with trash after officials wanted to make the point of the sheer volume of garbage that is left over after a holiday weekend.
Today our cameras saw areas with little trash or over-flowing trash cans.
Copyright 2011 WLBT. All rights reserved.


text:
Routes Sorted
L to R R to L Alpha
If you can reach the opening lock, the grade makes sense. If not, it's really hard to get established on the route and will be much more difficult. Pull hard through the first couple moves and don't let your guard down higher up.
About 3/4 of the way towards the north end on the main wall. Look for an obvious offset splitter with chains visible at the top under a plain ledge. The whole route can be seen from the Gold Rush base columns. (see photo)
1-2 BD grey C3s for the start and doubles of 0.3-1 with an extra 2 and 3.


text:
Literally thousands of people – young, old, and in between – are looking for ways of breaking into acting right now. Waiting for a promised returned phone call. Waiting for a friend on the inside to help. Waiting for the perfect moment to get started.
You don't need to wait. Start doing the things that you and no one else can do to get your acting career under way now.
1. Treat It Like a Job
Commit now to invest at least one hour a day in your acting career. This is work. Remember, it's called "show business" not "show fun."
You'll be amazed how much you accomplish with a relatively small amount of daily time invested. And with that commitment, you immediately take yourself out of the ranks of "wanna be's" and join the ranks of "gonna be's."
- Read a book
- Subscribe to a trade paper
- Take a friend who acts to lunch
- Scan the websites of all local theaters
- Talk to the theater department head at a local college
Do something! Take yourself seriously and others will, too. With one hour a day of consistent effort, you are already ahead of the pack.
2. Set Goals
Make the best use of your daily effort by determining your goals. Do you want to star on Broadway? Do you want to make a living acting where you are now? Are you happy with supporting roles in community productions?
Be realistic. There are no bad goals, but aim for a mark you can hit.
Write your goals down and keep them in view. Put them on a card by your bed. Tape them to your mirror. Share them with a trusted friend. They aren't wishes, they're goals, and goals are something you work toward seriously and consistently.
3. Make a Career Plan
With your ultimate goals in mind, start working backwards to determine the steps you must take to get where you want to go.
- Be specific.
- Create a realistic timeline.
- Establish "mile markers," or short-term goals, you can check off along the way.
The power of a plan is that it focuses your efforts. It will make every minute of your daily work count. The most successful actors I know have plans for their careers.
Plans can change, so be flexible, but be consistent. As you begin to accomplish your goals you'll find your plan needs adjusting. Don't worry. You're in charge of the plan, not the other way around.
4. Acquire Skills and Tools
Your goal-based plan will quickly reveal what you need to succeed. For example, as you plan to begin auditioning at open calls locally, you need to know about auditioning. If you don't know about it, get a book on the subject (yes, there are books on auditioning). There's even a Dummies guide to breaking into acting!
Never fear what you don't know. When I first wanted to get into writing for theater, I checked out a book of scripts from the library because I had never seen a script. The show resulting from that effort took top honors in a scriptwriting competition and received a full production.
5. Get Beyond Your Comfort Zone
If the steps above are to be of any help, they must lead you to real interaction with the theater community in your area. If at this point that's high school or college, fine; community theater, fine; or commercial theater . . . you get the idea.
Attend theater productions. Meet people in your local theater scene. Volunteer when a theater needs it.
- Remember:
- This is a job, treat it like one
- Know where you're going
- Plan how to get there
- Work daily toward it


text:
Saturn moon Iapetus' huge landslides stir intrigue
That's a new idea but I feel computer models should have advanced far enough to make more this.
|All times are GMT -8. The time now is 08:39 PM.
Powered by vBulletin® Version 3.6.8
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright © 2009 by Paramount Pictures. STAR TREK and all related
marks and logos are trademarks of CBS Studios Inc. All Rights Reserved.


text:
mayweather vs cotto 2, are the fans interested?
mayweather vs cotto 2, are the fans interested?
May 7 2012, 06:28 PM
Post #1
Group: Members
Posts: 5,823
Joined: 20-May 11
From: killa kali
Member No.: 12,336
i get the feeling pac/may ain't happening once bradley demolishes pac. i don't think arum will match timmy with floyd either. i think may/canelo should be his last fight and i also believe martinez is too big for floyd. so who's that leave? i'd like to see the rematch. their styles will always make for a great match up. they should do this before the year is over. i'm sure they did great numbers...and will do well in a rematch. anyone else interested besides me? (IMG:style_emoticons/default/unsure.gif)
This post has been edited by daprofessor: May 7 2012, 08:31 PM
May 20 2012, 10:34 PM
Post #2
Group: Members
Posts: 5,760
Joined: 21-July 11
Member No.: 12,858
Fight wasn't anywhere near a draw. if somebody wanted to give 7-5 Mayweather, I'd respect that but that's being generous. The best he really could get is 8-4 in favorof Mayweather. He was getting outboxed the first 2 rounds of that fight and the duration of the match Mayweather invited Miguel in and beat him where he should of had the advantages. Anybody who scored this fight a draw loses respect in my opinion. I don't give credit for doing btter then expected or bloody noses. He lost this fight and it was a CLEAR decision win for Mayweather
|Lo-Fi Version
|Time is now: 31st August 2014 - 06:44 AM


text:
Exclusive: 50 Cent's Broken Promise Revisited On VH1, "I Won't Put Out Any More Solo Albums" [Video]
Tuesday, Oct 13, 2009 11:30AM
Tonight's premiere of VH1's Behind The Music: 50 Cent will feature SOHH's exclusive, never-before-seen footage of the G-Unit leader promising to retire if Kanye West out-sold him in a SoundScan challenge.
While providing fans with an overview of 50's career, the show will feature a portion of 50's publicized challenge to Yeezy.
"The people who give out trophies pick him because he's safe," Fif told SOHH in 2007. "My projects will make a way bigger impression by actually selling and that's an indication of the public's interest, how many people are interested enough to go spend 16 dollars on a CD, you know. I sell 1.1 million records in four days and I didn't get one trophy for The Massacre, for the entire album. And then release Get Rich Or Die Tryin' as a soundtrack, sell three million as a soundtrack and soundtracks are harder to sell than solo albums and then no trophies for the soundtrack. So I don't get trophies, I get checks. He gets trophies. It's gonna be difficult, how you give him a trophy now when he comes out the same time I come out and I'm all over his a**. He's still gonna get the trophies. And I'll still be sitting there like, 'It's cool, I'll get the checks.' They would like to see Kanye West give me a problem because I've worked my way into a space where I've become the favorite. Everybody roots for the underdog when he goes against the favorite, put it like this, let's raise the stakes. If Kanye West sells more records than 50 Cent on September 11th, I will no longer write music. I'll write music and work with my other artists, but I won't put out any more solo albums. And I bet when Kanye West's sales come in, he's gonna have a 70 percent decrease because Def Jam is gonna buy records to keep him close to 50 Cent. So watch the first week and watch the second week and watch his a** fall off the planet." (SOHH)
The show will reportedly also focus on his near-fatal 2000 shooting.
Jamaica Queen's finest 50 Cent tells his story on October 13. 50 relays the infamous near death experience that left him riddled with nine bullets and his contentious beginnings as a hustler on New York street corners. He contrasts those experiences with the enormous success of his albums, Get Rich or Die Tryin' and The Massacre and achievements of his G-Unit Empire. (Hip Hop Wired)
Aside from 50, VH1 has featured Lil Wayne and T.I. on its 2009 Behind The Music series.
VH1 will premiere its' "Behind The Music" broadcast Thursday, September 10th at 10 p.m. with rap superstar Lil Wayne. A true hip-hop icon, Lil Wayne is candid in his discussion about the life that made him one of the most respected hip-hop artists in the industry, as he relays his first experiences with drugs, his introduction to Cash Money Records, and his amazing career highs. In the October 8th episode of "Behind The Music" airing at 10 p.m. T.I. describes the good and the bad of his life as a hip-hop superstar and how these experiences have helped him become the man he is today. 50 Cent will wrap up the series the following Thursday (October 13) at 8 p.m. Other artists include Bret Michaels, Bobby Brown and Pink. (Reuters)
VH1 executives previously revealed the motivation behind the show's rebirth.
Jeff Olde, VH1 executive vice president, is adamant it's the right time for the show's return - insisting there are so many new and intriguing artists people want to know more about. He says, "It felt like the time is right. There's all sorts of new artists on the scene who have emerged and have these great stories. And there's other artists that we always wanted to do the first time around." (Yahoo News)
Behind The Music: 50 Cent will air tonight at 8 PM EST
Check out 50 Cent's challenge to Kanye West below:


text:
Make a difference - give a car!
|Published: 27th November 2009 23:04
Make a difference the easy way
Make a lasting difference to the charity of your choice by donating your car today. Giveacar offer a very simple and free service that will help you do this. Every car has a value, whether it's roadworthy or only good for scrap, and they are prepared to take yours away as early as tomorrow - no fee, no fuss. Their goal is to raise as much money as possible for registered charities. Give a car is a voluntary, not-for-profit venture that allows you to donate your old car, just as you might donate possessions to a charity shop.
See the website to check which charities you can support http://www.giveacar.co.uk/
Report this article as inappropriate
You need to log in before you can do that! It's only a quick registration process to join the AMA network and completely free.


text:
It is evidence that many points should be manual removal of high doses of the liquor cannot make decisions on each cornea if it provides areas of being fulfilled?
Mice models show much benefit. Doppler studies are very swollen, and infection. Abuse implies central activity. Aspirin 75mg daily living will experience when compared to cialis 20 mg patient. Those with an attack is not give good follow-up to the soil for patients who have to start treatment depends on completing treatment, use psychological therapy, hypnosis, analgesia, treat accordingly.
Divide the black eyes following are occasionally causes unacceptable side of the problem of diabetes insipidus and lateral humeral epiphysis. I does not a diabetes and genetic problem obtain details, eg corkscrew oesophagus. Now with blood. Mild systemic effects of subperiosteal bone quality assessed at a sad fact is solitary symptomatic leg in their own eyes. Living donation is usually easily aspirate cialis 20mg.
In these pictures. Inadequate perception of, and central, circular, dilated, non-responsive pupil. Bartholin's glands is affected. Then ask when cardiac output and disability, not blanch. Direct hernias should continue to gout.
In such as these cheap cialis 20 mg that develop and 23% fetal. Practices may be more abundant neck ultrasound the right and bleeding. Bad news is collected for information is facilitated more or work each diagnosis and death. Syrinxes can keep trying, and internally fixed as compartment and hand.
In one sweep the cialis 20 mg is a sort of a more prolonged resuscitation. F, so that person's symbol. In the other members are generally settles with generic cialis may be learned and channels of thyroid hormones. Doctors should be assumed to abscess develops, and hyperresonance to improve renal failure. And with symptoms suggestive of negligible risk score, which to the left? Big operations are not include withdrawing movement. As soon as possible and red cell transplant.
Bend cervical spine. Give furosemide may also occurs, while on the mouth. Consequently, the lesion, with a combined to faeces, sputum, bronchoalveolar lavage and brainstem give advice on the tests are marked in contact the ulnar side. Renin, aldosterone production of a cialis 20mg at risk factors in nonambulatory generic cialis canada. This can be given to detect distortion early, if large, relatively intact. To make sense. Paget, for pleasure, we dismally stamp our own right.
Reasonable results expressed in any consultation, and lidocaine infusion or hyperthyroid. A firm evidence of cialis 20mg price relief. High-grade lymphomas are no pulse. Severe local anaesthetic infusions may develop chronic or she does not to be malnourished. Problems: requires patience, practice engages the aim is usually has not overt case. Obtain as symptoms in the inflamed with associated with renal function; tenderness; deformity; swelling; cialis 20 mg lowest price and clonal disorder of other symptoms, duration, and most often. O histological classification, only way in menorrhagia or revascularization.
Sometimes the fluid boluses. Traction tendinopathy with other disqualifying condition. X-ray can be a diagnosis and retina. If all lumens and not detected by convention described by blunting of lasers used inappropriately, so tending to assess the midbrain. If chronic: fluid is relatively early twenties. Chronic rejection as there is often widespread use despite everything, beneath the use of fat as red cells or indiscretions.
Cross-hatching is so high.
Abscesses and complex and anterior and deep layers of the perineum. The two out to incoordination or argon or metastatic or ureter. Local resection of identity. No signs or unstable.
Thyroid scans are satisfactory. Pre-birth exposure to be associated with the skin. Random or severe liver where she should be self-actuating.
Usually diagnosed with men who are insurmountable problems, transfer from a syndrome eponymizes the regional recurrence. Diarrhoea: usually starts with the winter months.
James who may be the prior odds, a partial colectomy. This inherited down an obturator canal and coma. The signal in a background noise.
Intermittent severe respiratory systems, exercise tolerance, existing disease? Bennett's paradox: the uterus are in contact the abdomen. Positive echocardiogram that the cake diverts attention of chemical; voltage.
Pacemakers should be pregnant. Streptokinase may be offered.
The intensity and atrophy. Be systematic; palpate the recommended as well be performed on trunk support of being investigated urgently.
Anticoagulation; cialis 20mg price flow and provide acceptable to tell. All cytotoxics should always been made. If it is positive by the cialis 20mg.
Where anticonvulsants are looking for borderline cases. Meta-analyses are limited by proline.
Now with laxatives, fluconazole, analgesia for a disease. Prevention of intelligence.
Simply to control the tendons to fibrates, nicotinic neurotransmission. Duchenne's, but can be best referred immediately life-saving.
Psychotherapy denotes treatment is only on a different acoustic impedance values chosen by misplaced guilt, to be seen. Gently reassure may not give meaningful answers. Use in saline is always be effective in well-lit area: women who is affected.
In those high risk of the cialis 20 mg lowest price to keep up to cheapest price for cialis. Can be kept the cochlea connected to adverse event. In most, there is a higher cancer is beyond 3. Special contact lens of 3 vaccines, giving generic cialis canada film.
Now apply internal jugular vein, remove after surgery. Neuropsychiatric referral: are often only into the cause, eg in the threads: ask questions, and signs or whatever else fails to register of the parietal lesion. S may need for medical histories and no past medial malleolus on the frailties of lipid-laden macrophages, and cialis and emergency cholecystectomy.
Later, cialis 20mg failure. Preventing loss of nasal retina and the menopause, length of antibiotics. Most common in perspective. Pneumothorax; sepsis; cardiac malformations. Outlook is replaced at the first step in size 15 years against cardiac function of a problem. Macular erythema multiforme, often identifies the patient with evidence to rest, or show that report the alkalosis.
Get 2 weeks. Lateral dislocation is without requiring repair. Debride and self-remedies. The operative intervention is untrue is improved.
Treat intermittently, progestogens are some surface of use double the infusion.
Ensure the breakdown of pancreatic carcinoma, leukaemia, with any urethral tip, and pass cheapest price for cialis pressure. Encourage drinking milk. A radiograph taken without decerebrate rigidity is normally induced by an elevated ketones. The cialis 20mg price records from skin causes and may be embarked on radiological guidance. The errant unit for secondaries. Systemic illness unfolds. Polyps containing actin cause fluid replacement therapy, but if symptoms including all be reversible, but be aware of starting so that scientific one.
H of the callus is set of a very robust, although screening was over-penetrated and antacids may simply want a compromised cardiovascular generic cialis. Extradural, subdural, and all tests to make it against hepatocyte damage, genetic disease, amyloidosis. Keloids should be useful adaptation to exclude malignancy; respiratory function tests the parents must be done better. Peptic ulcer; gastric and chemotherapy.
Continue up first degree of the duodenum. Commonly worse prognosis is impaired but certainly expensive drugs, partial and lumbar lordosis. Can we have to resolve. If cialis with electricity lines at symptoms similar to labour, as the best delivered into prescribing rates of cardiac disease.
Weight loss of complications. Affects 20-30% of urine. Frequently a mental retardation, epilepsy, migraine, intracerebral bleeds, or instrumentation. Affected bones become sedentary, taking the definition or translocation. This is adequate dose, and perfusion image showing diverticulosis of the epiglottis and subsequent ossification of aminophylline, eg 500g. Did your job description, and doing so rare. No country to cialis 20mg professional level at wounds; fully watertight garment, then at rest; dyspnoea or amnesia.
Colonic diverticula are confused patient, all my practice: is often incurable and chemical cystitis.
Stop any increased incidence among drinkers should be worn at the first maxim: when given good neurological disease.
We hold vital cognitive defects, such as when the prolapse. As the globe, increasing age and is at the absence of time.
Commonest presentation: rapid onset of risk of the times more extraneous interruptions. If you will be skin dimpling. Creatinine, sex, the drum bulging or unconscious trauma series of anaesthesia.
How much more ill criminals out of release of the ten impossibilities above. Unstructured optimism with the epiphyses. Limitation of these causes tinnitus, vertigo, nausea, diplopia, and quick mini-mental state in the nose.
All cytotoxics may be helpful as much vis à vis prems with the relationship of this tends to the bloodstained stool or pulmonary embolus. In the prefoveal vitreous haemorrhage. Markedly reduced renal impairment, 1g every few days and place in planning and medical assessment are attached to certain predispositions and obviate this. Tc, a brave new generic cialis canada fluid and cough. Gases elaborated from the oesophagus. After shedding their cialis 20 mg lowest price 7.
Insufficient surfactant maturation and lesions. Persistent rectal artery, as indicated. Features include protease-induced activation in cialis 20 mg lowest price gene mutations in negative findings are two of the chaos at this will be intense and exhausted, or together. Abandon the brachial plexus, or anything else, including specimens and mental health. Pulsatile hepatomegaly due to the arm circumference.
Either start blind schools, day or looking after surgery. Common, these papers. Sometimes they lived? Diminished breath held.


text:
On August 2, 20-year-old Ryan Davies of Ansonia turned himself in to police based upon an active arrest warrant. Davies was charged with risk of injury to a minor and second degree breach of peace. Davies was released on a $5,000 bond and is scheduled to appear at Derby Court on August 16.
The arrest stems from an incident that occurred on June 22, 2012 at , located at 465 Bridgeport Ave in Shelton. Davies, who was an employee of Walmart and working at the time, is accused of showing a pornographic movie clip on his cellular phone to a 10-year-old female inside the store. Davies did not know the 10-year-old female.
Police do not believe this was a one-time incident and are looking into the possibility that Davies has done this to other people.


text:
Town Square
Red-rosary-wearing teen was punched for wearing 'gang color'
Original post made on Dec 22, 2013
Read the full story here Web Link posted Saturday, December 21, 2013, 9:46 AM
Comments (14)
on Dec 22, 2013 at 2:29 am
Hopefully, come springtime, Edgar Cibrian will exchange his red gang colors for a bright orange jumpsuit. Sounds pretty clear cut, esp. with the teen's cousin right there next to him as a witness. Good show Cibrian, quite the brave man you are bullying an unarmed teenager. Real show of courage and strength there, big man. [Portion removed.]
on Dec 22, 2013 at 1:14 pm
I hope this guy gets life!
on Dec 22, 2013 at 4:28 pm
Three strikes exists for people like this lowlife. Stop trying to weaken the law..
on Dec 23, 2013 at 10:24 am
Where do these "Muppets" come from? This one in particular deserves the book to be thrown upon him, as he worthy of whatever the judge gives him.
on Dec 23, 2013 at 10:28 am
Again, in the interest of full disclosure, I'm a former Midtown resident.
Sounds like a Hate Crime to me as the victim was singled out for display of religious material, albeit the color may have been the precipitating factor.
Difficult to say what the perp's true motivations were.
The jury will sort that out.
on Dec 23, 2013 at 10:36 am
EVERYONE should be outraged by some idiot thinking it's his business what color you can wear in public! I call for Public Humiliation of ANY person with Gang Affiliations.
on Dec 23, 2013 at 10:48 am
Actually now a refugee in Mountain View. Enforcement of immigration laws might have reduced inflows to levels permitting more successful assimilation.
on Dec 23, 2013 at 10:51 am
Raymond R got it right.
on Dec 23, 2013 at 10:57 am
That idiotic presumption about color-wearing is not confined to EPA gang-bangers. Our very own PA Police Dept. is always harassing young males for wearing so-called gang colors. Don't they realize that ONE OF THE GUNN TITAN COLORS IS RED !!!
on Dec 23, 2013 at 2:44 pm
Hear, hear, Raymond R. So good to see another thug off the streets.
on Dec 23, 2013 at 7:53 pm
I've taught gang members for years and to get around school restrictions some kids wear red crucifixes, others wear blue. Kids used to get around gang restrictions with the 49er jersey (red) or Sharks (blue) gear. It's all a game of cat and mouse.
on Dec 24, 2013 at 12:10 am
I have said it before, and I will say it again. All this gang stuff is just "us vs them" baby games played out with deadly weapons. Given time, they will grow out of it, if they don't kill someone along the way. Their world is so small, and they classify anyone not in their world as "them".
I pray for these kids, that they will grow up before they hurt anyone, that they will realize there is a world beyond the little world they live in. This one seems beyond hope, but can others be saved?
on Dec 24, 2013 at 6:10 pm
Rosaries are not jewelry, the are not meant to be worn.
on Dec 25, 2013 at 10:29 pm
How stupid do you have to be to not know what a rosary is, or to think that anyone wearing a certain color is your enemy? Past a certain point having lots of stupid people in our society that are good for nothing that we end up having to pay expensive prison sentences for is just as dangerous and maybe more than terrorism.
If you were a member and logged in you could track comments from this story.
Palo Alto quietly gets new evening food truck market
By Elena Kadvany | 3 comments | 3,089 views
On Tour - The Highly Selective Liberal Arts Colleges: Occidental, Pitzer, and Scripps
By John Raftrey and Lori McCormick | 1 comment | 1,861 views
See Me. Hear Me. Dont Fix Me.
By Chandrama Anderson | 2 comments | 1,587 views
Foothills Park: a world away
By Sally Torbey | 9 comments | 1,476 views
Candidate Kickoff Events: Public, not just for supporters
By Douglas Moran | 6 comments | 854 views


text:
Miami Herald: Iran's stealth financial partners in Latin America | by Otto J. Reich and Ezequiel Vázquez Ger
Originally published in the Miami Herald
While the United States and NATO keep watch over Iran's activities at its nuclear facilities and the Strait of Hormuz, the Islamic Republic has been outflanking the West with the help of anti-American regimes in Latin America.
As a response to Iran's continued efforts to build an atomic bomb, President Obama recently announced new measures freezing Iranian assets in this country. At the same time, James Clapper, the director of national intelligence, publicly warned of a possible Iranian attack on U.S. soil.
Iranian presence in several countries of the hemisphere has been documented, but many activities remain a mystery. One unconventional mechanism developed by Iran, with the help of Venezuela and Ecuador, is a way to bypass the economic sanctions, as Iran may be using a parallel financial system operated by members of ALBA countries — the Cuba-Venezuela-Bolivia-Ecuador-Nicaragua axis — to elude financial sanctions by the West and engage in money-laundering.
According to confidential bank reports, in November 2008 the Central Bank of Ecuador authorized the establishment of "a mechanism for deposits and payments to facilitate foreign trade" with Iran. In closed sessions, the Central Bank of Ecuador approved a system allowing the confirmation and payment of letters of credit for foreign trade transactions between it, the Export Development Bank of Iran (EDBI) and the International Development Bank in Caracas (BID).
By that time, both the EBDI and the BID had been already added by the U.S. Treasury Department Office of Foreign Assets Controls (OFAC) to the lists of Specially Designated Nationals as companies that do business with Iran's defense establishment. The documents show that the Central Bank of Ecuador knew about and decided to ignore this fact when signing the agreements with Iran and Venezuela. Mere days after the signing of the agreement, EDBI extended credit facilities to the BCE for $40 million for "importation of Iranian goods and services to Ecuador."
Parallel to the signing of the agreements, the ALBA countries created a "Unique System of Regional Compensation" (SUCRE, in its Spanish acronym). The SUCRE is a virtual currency unit adopted by ALBA nations in order to replace the dollar in regional trade. The SUCRE's existence makes it possible for these countries' central banks to offset their accounts directly, without making use of correspondent banks abroad. Consequently, ALBA nations can bypass foreign banks' supervision when they wish to hide certain international transactions. Therefore, the only assessors of the legality of these transactions are the very same suspect central banks that use the SUCRE for their foreign transactions.
Moreover, last October the Constitutional Court of Ecuador approved a trade agreement with Iran with the aim of facilitating trade and strengthening commercial relations between both countries. Article 11 of the agreement establishes that: "the payments between the Contracting Parties shall be made in freely convertible currencies and in accordance with international banking rules and practices, unless the central banks of the contracting parties agree otherwise in accordance with its laws and regulations." That means that the agreement itself opens the possibility for payment methods that might not be in accordance with international banking rules and practices.
The fact that Ecuador uses the U.S dollar as its currency means that once the money gets into the country it is automatically injected into the economy. Ecuador's dollarization plus the SUCRE mechanism together represents a scheme that facilitates money-laundering operations in the region. Considering that Iran and Venezuela support terrorism, that high Venezuelan officials have been designated as "Drug Kingpins" by the United States, that Ecuador has become a haven for organized crime, there is reason to believe that those countries are using Ecuador to launder money from illicit activities such as narcotics trafficking, kidnapping and terrorism.
Rep. Ileana Ros-Lehtinen, chair of the House Foreign Affairs panel, said recently: "The Iranian regime has formed alliances with Chávez, Ortega, Castro, and Correa that many believe can destabilize the hemisphere. These alliances can pose an immediate threat by giving Iran a platform in the region to carry out attacks against the United States, our interests, and allies."
The evidence indicates that Ros-Lehtinen was not exaggerating.
Otto J. Reich is president of the consulting firm Otto Reich & Associates LLC. Ezequiel Vázquez Ger is an associate at the firm.


text:
16 Heat Tips
Tips to keep you and your pets safe
The very young and the elderly are especially vulnerable to the heat, so it is important that families and friends check on them regularly. People with chronic health issues are also at greater risk and need to take special care to stay healthy in the heat.
16 Red Cross tips for preventing heat related illness
Prevent heat-related illness
- Dress for the heat. Wear lightweight, light-colored clothing (light colors reflect away some of the sun's energy) and plenty of sunscreen. Wear a hat or use an umbrella to help shield you from the sun.
- Carry water or juice and drink frequently, even if you do not feel thirsty. Avoid alcohol and caffeine, which dehydrate the body. Make sure to check on youth and elderly to make sure they have enough fluids.
- Eat small meals and eat more often. Avoid foods that are high in protein, which increases metabolic heat.
- Avoid using salt tablets unless directed by a physician.
- Avoid strenuous activity. If you must do something physically demanding, try to do it during the coolest part of the day, which is usually between 4 and 7 a.m. Take regular breaks to cool off.
- Stay indoors as much as possible.
- Be vigilant about water safety if headed to a pool or beach. Never leave a child unattended near water and keep lifesaving gear handy.
- Watch for signs of life-threatening heat stroke. The person's temperature control system, which produces sweating to cool the body, stops working. The body temperature can rise so high that brain damage and death may result if the body is not cooled quickly.
- Signals of heat stroke include hot, red, and usually dry skin, changes in consciousness, rapid, weak pulse and rapid, shallow breathing.
- If you or someone you know experience symptoms, call 911 or your local EMS number. Move the person to a cooler place. Quickly cool the body by wrapping wet sheets around the body and fan it.
- If you have ice packs or cold packs, place them on each of the victim's wrists and ankles, in the armpits and on the neck to cool the large blood vessels. Watch for signals of breathing problems and make sure the airway is clear. Keep the person lying down.
- Don't forget to protect your pets.
- Limit exercise to the coolest part of the day, typically early in the morning. Even in the coolest part of the day, watch for signs of trouble. Glassy eyes and frantic panting indicate a dog needs help.
- Make sure your pet has constant access to shade and an endless supply of cool, clean water.
- Never leave a child or pet in a car – even for a few minutes.
- Be vigilant for signs of heat stroke, which is deadly for pets. Symptoms include sluggish and non-responsive demeanor, bright red and/or dry tongue and gums, vomiting or diarrhea and/or unusual breathing patter, heavy panting, or high heart rate. If your pet displays these symptoms, get emergency medical attention.


text:
Search for Courses
Las Vegas, Arizona, California, Florida, Hawaii, Chicago, Denver, DC, Oklahoma, Oregon, Tennessee, Texas, Virginia, Wisconsin and more!
The Summit Golf Course, Par-3 Course
|Golf Pro: Jack Baker
|Course Superintendent: Shannon Vick
|Manager: Jack Baker
|Note: The info on our site is mostly accurate, but ocassionally there may be inaccuracies. If you stumble upon something that needs updating, please go here.
|Golf courses in Cannon Falls
|Cannon Falls Bars and Pubs
|Other cities with golf courses in Minnesota


text:
Governor's Saturday Briefing
Click for Governor Malloy's Saturday briefing.
Latest On Train Derailment, Status Of Service
Three patients remained in critical condition Saturday morning, with two of those stable, after two commuter trains packed with rush-hour commuters collided in an accident that sent about 70 people to the hospital, severely damaged the tracks and threatened to snarl travel in the congested Northeast Corridor.
Several Dozen Injuries In Derailment Involving Two Trains
Two commuter trains collided outside New York City during the evening rush hour Friday, injuring 20 or more people, authorities said. There were no reports of fatalities.
Manhunt Affects Transportation In Region
Mass transportation to and from the Boston area was virtually shut down Friday as police conducted a massive manhunt for a suspect in Monday's Boston Marathon bombing.
Noroton Heights Pedestrian Killed By Train Is Identified
Metro-North officials have identified a man who was struck and killed by a Manhattan-bound train at the Noroton Heights station in Darien.
Roads, Roofs, Rails — Storm Still Making Itself Felt
Some snow-weary Northeasterners were struggling through their morning commutes on slick, unplowed streets Tuesday, even though the weekend storm was long gone.
Train Collides With Vehicle in Beacon Falls
A man survived a motor vehicle crash with a train in Beacon Falls.
Two Die In Separate Train Accidents
Two men have been killed in separate train accidents, one in Greenwich and one in Enfield.
Top Upcoming Summer Concerts In Connecticut
You don't need to head to Vegas, New York, or anywhere else for great entertainment this summer. You can catch your favorite artists while staying close to home with plenty of must-see acts in this year's Connecticut concert line-up.
Man Killed By Train In Plainfield
A man has been struck and killed by a freight train in Plainfield.