text:
Overclockers Forums
another Crucial Ballistix thread...
Corsair Dominator FSB question
Memory experts, please help with timings
Never buying Crucial Ballistix AGAIN!!
Help for a NOOB please
Corsair 8500C5 4GB Results
Memtest stable but not ORTHOS stable?
Good Laptop Ram?
what are memory timeings
OCZ problems
Ancient RAM (KVR400X64C3A/512 * 4)
higher freq VS Lower Times
pc2 8500?????
OCZ special ops?
RAM or MB issue?
RAM experts, is it just me or do most 4GB DDR2 kits seem about the same?
kingston hyperx 2x2gigs with a amdx2 5000+
need alittle help with memeory
chip specs
Crucial and DEAD BALLISTIX TALE!
G.Skill 2x2GB PC2-6400 5-5-5-15 experience (4GBPQ)
Paged Physical (k) Memory
News from STT
Who has OCed an iMac G3?
MetaRAM technology to cut server and workstation memory costs by up to 90 percent
P5K Deluxe no POST with Dual Channel
just a quick question
will i notice much difference on gskil 6400 and g skill 8000 RAM?
Loosen Timings?
ballistix tracer error help plz..
Problem With New Build - 2 Bad Memory Modules?
PC 133 168pin memory
Loosen Timings further to get 890Mhz Stable?
What would be a great choice?
Which memory ?
Memory for E8400 and Abit ip35 pro
Little confused - memory divider
What timings for OCZ Platinum Rev.2 DDR2-800 .. 4-4-4-12 or 5-5-5-15
New Corsair 4gb DDR2 Kits and the ICs Used
Best RAM for my setup/overclocking?
Corsair XMS and XMS2 - What is the diff?
Memtest86+ V2.01 Released
memory recommendation
8GB (4x2GB) G.Skill @ 1068MHz
Laptop Ram
did I make a bad choice of memory?
Memory Problems
Speeding up memory with Trd
Memory not running dual channel
What are the other mem timings besides the usual ones?
upgrade from 533mhz
Cas Latency locked at 5! Please Help!
ram issue with evga 680i
Choosing new DDR2...help :)
This is the fastest DDR2 isn't it?
How much RAM?
mem timings and memtest question??
Bad Ram Bandwidth!
ram oc help
Ballistix RMA
Failing Orthose Blend test (I think its the ram)
Looking for Ballistix alternative's
OCZ DDR Booster Help
The final Build - SLI - 780I - E8500 - Take a look!
Memory Setup
DDR2 Ram Problem
RAM or MB?
Corsair Problems New Build
4GB GSkill F2-8500CL5D-4GBPK
Ok, so is this a good result?
installed 4gb of RAM only 2,814mb are showing up
Recommend me a good 2x1GB DDR2
DDR 500 Recommendation
Is DDR2 1066 worth the majorly higher price over 800
5-5-5-15 or 4-4-4-12 @ diff mhz?
2GB G.Skill F2-8500CL5D-2GBPK 8 Layer PCB non-Micron ICs
Different bandwidths?
noob question help please
Would there be any point at all to 6GB of RAM?
Ballistix Tracer mod (pics)
OCZ ReaperX HPC DDR3 Yes/No?
need help picking out ram for new rig
I just dont know and ive read too much on RAM any help appreciated
Memtest and Windows Don't See 4GBs Memory
Corsair XMS2 PC2 8500
Have your Ballistix ever needed to be RMA'd?
2 gigs..no prob....4 gigs...not working
Ballistix Tracer timings?
how to choose ram
Bios Memory Multipliers: A,B,C,D 2.0,2.66,etc... WHAT DOES IT ALL MEAN?
After updating BIOS, RAM not running on stock timings
OCZ PC2 8500 Settings Question 4 SteveOCZ
Not a Memory Expert, does this sound right?
Need Help, keep failing Memtest 6
Memtest 86: passes question
Ram voltage stock on p35-ds4
Ordered the g.skill 2x2 1000mhz
Memory Question
Corsair XMS2 PC6400
The 4GB memory doubts :S
Intel Sampling Phase-Change Memory
A-Data DDR2 800+ Vitesta Timing Issues
n00b hardware question
Memtest found 150,000+ errors on first test?
ratio vs mhz vs timings
ocz stability problem
Ballistix RMA... Makes me wonder....
Memtest86+ 2.00 Official
Adata DDR2-800 Voltage
Ballistix Tracer Vs. Corsair Dominator
Mem roadblock possibly?
DRAM IC queries
Maybe I'm blind but i can't seem to find if these corsairs (2x2) is oc worthy!
2GB 1066mhz or 4GB 800mhz?
BH-5 Help
need rambus help!
best way to cool the memory?
Patriot DDR800 Underclock
mem won't run above 1000MHz on new mobo
I just don't get it... Am I stupid or what? HELP Please!
Overclocking E8400
Any clocking expierence w/ these?
Can't Reduce Memory Timings
ATTN!! OCZ Customers using PC2-8500 / PC2-9200 / PC2-9600 Memory Kits
4GB of RAM
New to overclocking..
Memory for Asus board and e8400
OCZ Reaper PC3-8500E?
Ballistix - Which would you suggest for an OC rig?
Unlinked overclocking
Ballistix Tracer DDR2 8500 LED's won't blink at proper speeds
bad ram question
Looking for a quanty 1200mhz ddr2 Memory!
Patriot Extreme Performance not timing correctly
pic of errors in memtest,
Does this look right? (PICTURE)
Looking for ram to go with a e8400
More dead Ballistix
Intel DG965RY MOBO G.SKILL DDRII PC2-6400
why is DDR so much more expensive then DDR2??
DDR2 for P5N32-E Sli Vista x64
Tried out some different settings...thoughts?
Adjusting those "other" timings
help with memory clock
how do I optomize my D data DDR2 800 ram?
Corsair SPD conflict?
thoughts on OCZ Reaper HPC Edition
Why do Crucial Ballistix have such a bad rep?
Dual Channel Help
Ready Boost. More RAM vs USB drive
6GB Setup questions.
Some RAM OC Questions...
Low Density? High Density? Help!
Problems getting Crucial Ballistix 6400 to post
Mushkin 4GB XP2-8000 � Return of Redline!
anyone know how good this ram is??
2.35vmem too much for 24/7?
4GB ddr2 vs 2GB ddr3
Anyone tried the Super Talent DDR3-14400 sticks?
I think my G.Skill HZ's are Bad!
Looking for a good guide for adjusting DDR2 800 latencies
Rated Voltage vs. OC Potential
help with optimum speed
8GB (4x2GB) OCZ SLI ready + Abit IP35pro, any known issues?
Memtest86+ v2.0 Beta is here!
Incompatible ram?
DDR2 800 question
Good Overclock memory
I Do Not Understand my MemTest Issue: Need Advice
4 gig ram not showing up
Asus ROG Rampage Formula mobo review with some very interesting Memory discussions.
Problems with OCing ram
Suddenly I need to raise volts wtf
DDR3 timings using DDR2 speeds
2x1GB @ 1066 or 2x2GB @ 800?
Have 4gb ram motherboard reads it as 3.5 gb
Speed not Quanity
Memory recomendations new board & Q6600
Why Is DDR2 Cheaper Than DDR
memory timing...
Are these really micron D9's?
memtest86 error, then halt hours later
4gb of ram on x32 vista question
Is there any difference between SD and SDHC memory cards?
About to make a purchse, have some memory questions
Am I at full potential??
FSB and memory confusing me!!!
DDR2 high density upgrade
memory bottleneck?
G.Skill PC2-8000-4GBPK vs 4GBPQ
Transcend aXeram DDR2 1200 (2x1GB)
2GB OCZ questions
Some new questions for ya
4 Gigs Showing up as 3.5 Gigs Why?
FATAL ERROR: Rounding was 0.5, expected less than 0.4???
Hey guys and girls just a quick ?
Which Memory set is faster?
Need info on these IC's on some DDR2 i found
good buy?
Ballistix voltage
Overclocking Crucial Ballistix 800Mhz
prob ocing past 220 with good memory...
Faulty rams ?
Winpie and Outrider memory stress test
ddr2 wont run at 600mhz
Do Laptops even use 3Gb of Ram?
Damn it 5.5
Help with memory.
Dual Channel mode?
Fried RAM?
First Overclock: some memory questions
Changing 2T to 1T --> can't boot
2.75 out of 4 normal too?
"SLi Memory" is it better?
What DDR2-6400
its gotta be really cheap D9s. 1066 and 800Mhz!
Just another 4GB thread (�.� )~
Crucial Memory Won't Work With Old Help!
Asus Crosshair.. Memory Confusion
Overclocking Patriot DDR2- 800
Win xp and Game ERRORS with crucial ballistix
Mix Ballistix Tracers with Regular 6400 Ballistix?
How far to OC Memory
every see Elpida ram?
mushkin ram how is it? (pc6400)
If you were to buy 4GB of ram.......
RAM for NF4 MOBO
Buying four seperate sticks
How bad exactly is using 4x1GB sticks for OCing?
ram upgrade
0x...05 BSOD even after 12 hour stable p95 run??
Need some advice!
Trying to OC my Ballistix
how much ram will work with a typical mobo.
DDR and DDR2 Backwards Compatibility?
How are my timings?
I have Win XP 32 bit, so should I only install 2GB?
Difficult dilemma, need suggestions
800 or 1066 speed memory?
4GB of ram switch OS?
Can 1x 1GB and 2x512mb DDR Be Dual Channel
RAM disparity between sticks
fsb:ram 4:5
help with memory please ... thanks
Need ram!!!
Ram from CES sporting their own heatsinks
Which DDR3 for my Q6600 G0 and P35C-DS3R Mobo
will ram be a hinderance to Overclock
Anything wrong with generic "Value RAM" if I'm not OCing?
4x1GB Crucial Ballistix in P5K Premium
Who's running 4gb of memory on vista?
best ram for Overclocking
Why is memory amount limited?
another - "which RAM to buy?" thread
and now for p5e ram
Is this okay?
Share Video Memory
For Core 2 Duo, does having your memory and FSB in synch matter?
Mushkin timings
Max Memory vs. # of slots
wierd ram?
additional 2GB of ram purchase/installation question
ASUS Commando & 4 Sticks of Ballistix Tracer
RAM not running at default values?
Ram OC/Divider Issue (plz help)
Should pagefile be disabled when using 4+GB's?
Can I use DDR & DDR2 @ same time?
OC of Corsair Twin2X PC5400
What memory for my Q6600 and P35c-DS3r mobo
My Computer won't show all my RAM
Help me pick my ram
5-5-5-18 Timing?
New RAM Issue
Perormance difference between 2x1gb, and 4x1gb
Overclocking Memory - DDR2-1000
Help me quickly understand this RAM issue
DDR2 timings question
thinking of picking up 8gb
Add 2gbs or Replace 2gbs
2 gigs or 4 gigs of ddr2 ram?
overclocking samsung TCCD
Looking for a thread crucial ballistix \ heatsink off one side
Team Xtreem....which one?
Good brand to get wih good warranty coverage?
need help on what ram to get for a new system
Corsair Questions :D
Super Talent 4GB DDR2 2x2GB PC6400 800mhz
OC Report :: Corsair Dominator 2x1GB PC3-14400 CL7
Dell Inspiron 530 ddr5300 vs ddr 6400
ballistix question
Settings: Asus P5B-E Bios
PC2-6400 vs PC2-8500 on ASUS P5K-E?
question about crucial sdram
halp with the mem.
Should I buy ddr2 1200 memory since I'm going to overclock my system anyway.
Um, 1760Mhz FSB on my Corsair PC8500
Overclocking Corsair Ram and CPU
1066 ram on a GA-P35-DS4? Or should I stick with 800?
Corsair Ram
patriot extreme performance LowL
IMPOSSIBLE to get my Ballistix Tracers 8500 at 1066MHz, help!
OCZ or Crucial
How does Patriot Signature Line (basically Value Line) overclock?
Weird Memory/OC Issue...
should i expect any probs?
Help With RAM Choice
Boot problems, Memory failure? HELP!
Lost video card when ram added
Is putting +0.4v on my ram harmful?
Weird results in 3d mark with timings and FSB
I got a question
CPU-Z Missing Memory?
Which memory should I get?
High density vs Low density RAM....
Dell and Memory...
Looking for non-D9 based DDR2
choices for DDR3 in jan/feb?
Which Micron D9 DDR2 Ram?
is usng PC2-6400 BAllistix wit E6750 underclocking FSB?
GSkill RAM question
memory never used pagefile just bloats
Question About Buying RAM For My New System
4GB DDR2 kit questions
need help with 2X2GB choices
Linux memory benchmark
Question on OCZ PC3200 ocz4002048eldcpe-k EL Dual CH Platinum 2gig ram?
3 sticks of RAM no good for E2160/DS3L system?
GeIL 4GB (2x2GB) PC2-6400C5 800MHz Black Dragon DDR2 Dual Channel Kit
? to O/C or mod OCZ PC6400 Gold to PC8000?
Memory Advice wanted
I need DDR2 that's tight!
Transcend JETRAM 2GB
OCZ FlexXLC PC9200 - spontaneously dying?
GeIL EVO ONE 2GB (2 x 1GB)
4x512 seen as 654
Quad-Pumped you up!
A DATA 800 ram.
G.skill PC2-8000 4GB 2X2GB with Asus P5k Deluxe with Wifi AP
Which RAM for O/Cing? 2GB, <�60, DDR2 800, PC6400
ram temps ??
Any idea what the dividers are for the RAM when you go over a 15 Multi?
Dell Inspiron 530 memory help
Keep an eye out...they're going to try to raise the prices on us again!
RAM overclock guidance
Acer 5315 RAM question
New System Build Out - First Time Overclocking, need some help
Can't OC with 4 sticks - works fine with 2
Help clocking mushkins to DDR2 1200Mhz
BallistiX PC6400 Timings, Vista fails to Boot
A-Data Vitesta Extreme Edition
Memory Clocking Problems
need opinions
OC Report :: Buffalo FireStix 2x1GB PC2-9600 CL5
Gigabyte RAM multipliers?
Highest safe DDR2 voltage
Memory Divider
Good DDR2 to couple with AMD
Flash your OCZ Ram
Sell me to non Micron chips!
DDR3 a good move yet?
new memory
Can this RAM be OC'd (DD2 667)
DIMM slots
Best RAM to go to 8GB on a ASUS P5WDH Deluxe?
Options Options Options
M2N-SLI Deluxe ocz ram help me im a noob
pc6400 g. skill problems.
512MB sticks show up as 446MB
Memory Question
Ballistix Tracer Questions
Micron Creates "world's Smallest" DDR2 Memory Chip
1066 memory in 800 board
Vista 64, can only use 3.3gigs of ram
4 gigs only 2.8 showing
Corsair Dominator
Bandwidth Vs. MHz
Get More of same ram or new ram?
i-RAM Box ??????
Memory problems
4gb ram **NOTHING HAPPENS**
Suggestions for 2GB for 939?
Maximum bandwidth for multicores
RAMBUS: Is my stick 45ns or 40ns?
a-dat ?
Questions about memory speeds and settings
Should I buy it now?
OCZ SLI-Optimized DDR2 800, works with crossfire?
oc w/ 4 sticks
My Crucial Ballistix 1066 showing up as 800?
upgrading AMD X2 gaming rig
RAM and 64-bit stuff
Problem w/ Ballistix memory
RAM divider question?
Upgraded to 4 gigs
Is my computer using to much physical memory at idle?
After 7 years, still cant find cheap PC1066 RAMBUS cheap???
4GB w/ SLI and XP
Optimizing RAM Timings ...
crucial Ballistix pc5300
ECC in nF4-D?
4 x 2GB OCZ SLI-Ready Edition OCZ2N800SR4GK DDR2-800
Anyone used the Patriot DDR2 800 (4-4-4-12) @ 2.2 (PDC22G6400LLK)?
New Memory for Q6700 on DG33TL
memory upgrade for Toshiba Satellite A105-S1014
DDR2 voltage and timings, quick questions
Memory Help - just general questions
What's the best brand named ram nowadays?
Mixing memory speeds ????
PC 4600 memory?
SD memory card
RAM Timings Quick Question
Memory OC Question
Memory running at 6400 speeds at 1068MHz?
Crucial Ballistix Overclocking
pros and cons of 4x512 setup
xtreem dark vs geil ultra vs black dragon
Memory BIOS question
Memory Timings
Best 4Gb setup configuration?
OCZ Introduces 8Gb PC 6400 Kit.
CAS4 DDR3 :whoa:
DDR2 800 4GB - 4-4-4-12 - Sandra scores 4900????
Which memory is better?
Just how do you read memtest results?
Vista killing my memory?
Is it unhealthy to tweak memory timing too much?
Which of these 2 sets to buy?
Memtest question
Memtest testing all 4GB?
(urgent help needed) Two different sets of same Crucial RAM? Do they differ at all?
Poor benchmark scores -- What Gives?
Faulty DDR2 batches
Need help with my RAM
Which memory is better?
Need help on what new RAM to buy if this was your own system? plz help
RAM worn out? Craving for more and more juice...
Dual Channel Or No??
Which RAM to buy???
Is it true that if you buy 1000mhz+ RAM..
safe voltage for "value" ram
Rambus is like a snake!!
Best 4gb DDR2 800 ram kit for a Quad6600 + Evga 680i A1 mobo
Anyone have experience using windows run MemTest 3.6?
Hmmm, guess I messed things up....
What is better 800mhz 4/4/4/12 or 1000mhz 5/5/5/15 ... and also
Properties say 191mb of ram but system information says 256.
Bad Ram?
How do I check to see the PC-#### of my ram
Need help with changing memory timings
OCZ RMA question
memory for GA-P35-DS3L
Memory Dump
Need an answer to my RAM dilemma Today 11/26/07 :/
RAM Busted? Lots of BSOD, Curicial Ballistix 800
Memtest failing question
Ram ceiling or FSB?
3G is really 4G in 32bit OS's?
gskill wont reply too my rma request for my 1gb hz
ballistix color fade
i have a quick question about ram
SanDisk cruzer micro 4gig decent?
Weird Situation with DDR 2100 Sticks...
Which memory is a better choice?
I need some memory
Memory 4 x 1gb
benefit to run 2x2 gigs instead of 2x1 gig with windos vista
Replacing non-compliant memory with ?
PLZ HELP!! 4 gig Ram Causing NO SIGNAL!!
Additional Memory
Cut the chase on ram
Best quality PC2-8500 ram and good for overclocking?
Great deal on ram!?!
Need RAM Timing help!
Bad stick, after 6 months out of the blue
Can't run 4x512MB in my 939 rig no matter what I do. Any suggestions?
Win Vista 32bit and 3GB Ram issue.
My dominator CPU-Z'd...
ASUS P5B w/8GB PC-6400
Which RAM for brisbane email@example.com?
Crucial ram...to get or not .
M2R32-MVP w/ 2gb Corsair Dominator Issues
Diff between 5400 and 5300 DDR2 memory
Considering PC 8500
Memory Upgrades
Does anyone know for sure if Kingston RAM will work in a Dell?
Any D9s in 2x2GB configurations?
What does the "U" Mean? ex: PC3200U
3GB For XP Dual Loss To Single
Hynic Goes GDDR5
I f-ed up my sticks timing...
G-Skill DDR-8000 or Crucial Ballistix 6400?


text:
MMA as we know it is about to hit fast forward much like it did just before the WEC joined the UFC and super cards became common-place. The sport we know and love is experiencing the calm before the storm of further evolution and Ill tell you why.
The gene pool of athletes is becoming less and less exclusive to just the main stream sports. Physical specimens are making the transition to not only MMA early but also from other sports to MMA later on. Instead of sticking with basketball or football , genetic anomalies are making their mark in MMA more and more. Also great athletes are transitioning from wrestling and boxing into various martial arts and MMA. After the jump Ill provide some examples and show the immediate impact they've had and or success they have attained.
The fact that better and better athletes are coming to MMA or starting MMA early means a few things and also requires a few things.
Implications of freak athletes making up a larger % of fighters at the highest levels of MMA.
1.) The training for other fighters will have to be enhanced in order to keep up resulting in better fighters and less 'off' nights.
2.) Crazier more exciting highlights to not only promote cards to die hard fans but to also make it into the sportscenter top 10 and or mainstream sport highlight reels. This creates more positive attention and results in larger revenue in many ways for the MMA promotions.
3.) More intriguing match ups that will negate the redundancy of such arguments like wrestling is always better than judo and muay thai is the karate killer and greco roman is better than catch wrestling for MMA and so forth .
4.) weaker cards are now good cards regardless of experience.
5.) records will mean more instead of bitching about winning streaks because they were against 'cans' or no namers.
6.) It will be easier for such athletes to assimilate more facets of martials arts from all styles etc and create their own way instead of the cookie cutter wrestler with some muay thai and various chokes.
7.) better athletes create better camps for all fighters and new fighters to attend.
8.) last but not least the new wave brings a new face to MMA over all which is cleaner more distinguished individuals. Not Roy nelson the Larry the cable guy of mma and mediocre fighters who don't make up for the fact that they look like convicts or street punks with their skills and performances.
Things that need to happen to acclimate the MMA world for this next step in the evolution of MMA as a sport and not just and entertainment form.
1.) fights need better judges - horrible judging isn't a joke and it should be tolerated from anyone.
2.) refs need to ref the fight for fairness , safety , and also for the fans . Lay and pray needs to be erased.
3.) up-kicks should be allowed to make the playing field more even since getting a blanket weighing the same or possibly more than you that wont let go off of you is pretty damn exhausting and annoying. The fans and fighters want a fight not a test of grip strength and hugging prowess.
4.) Sudden deaths for draws and new round or time format to encourage better and faster exchanges.
5.) a substance screening program that makes sense . IMO it should be based on levels determined by a third party as safe and reasonable which allows for fighters to have freedom without too much or too little. Testing should be done on levels and not by substance as pertaining to performance enhancers . Narcotics etc should still be completely illegal and inexcusable. By testing for levels and not substances I mean that various levels should be tested rather than blood and urine for chemicals injected or taken to give the fighters some freedom on what they feel is safe for them or not safe for them while also keeping an eye on the levels of certain hormones etc to make sure that fighters are healthy and primed and that the playing field is pretty damn fair.
IMO testing should be done as follows . 2 weeks before the fight, the day before and just after the fight test for levels of the following
1.) free testosterone
2.) EPO levels
3.) IGF-1 levels
4.) norepinephrine and epinephrine levels
And last but not least a clear and concise format on which judges are looking for and favoring in different areas of the fight for the fans and also the fighters to know and understand completely.
Now follow me after the jump to look at some freak athletes that have made the transition to MMA or have made their way to the top !!
as much as i dislike the guy - jon jones is the new wave of mma greatness and like it or not a lot of it is his genes . Hes a phenom.
via bonesnapper.com
this is an obvious example - he could be good at anything he set his mind too
a boxer who has made mma his home with rediculous speed and coordination
via urdirt.com
the speed that this guy has for his size is insane
this guy is a soccer wiz and an insane athlete especially for his weight class
his mark on the sport was short lived but damn what a freak
a perfect example of an athlete with a ridiculous training regimen
this speaks for itself
via xfighterhayabusa.files.wordpress.com
imo the best athlete in the hw division
via imgboot.com
such a complete athlete
via i55.tinypic.com
shambler vs mitrione in the windy city !!
via fbcdn-sphotos-a.akamaihd.net
There are many more examples and thoughts pertaining to this subject so have at it maniacs , lemme know what you think about the fighters and my points and also if I missed some things that you all have been saying .

subset: commoncrawl


text:
We won! Best Short Documentary Garden State Film Festival
26 Mar
When can we see the film?
Come back & see us at the Tractor Tavern in Seattle soon.
Many Congratulations– I'd love to see the film.
How do we get to see the film?
Hi, Mary,
I'm a fan, since first hearing your music about a year ago. I live in the Washington, DC area and check your schedule for possible performances here, but haven't seen DC on your agenda. Your performances in NY are just far enough away to make it difficult to get up there.
Any chance of coming to DC? I don't know which venue here would be best for you…it seems the Birchmere in Alexandria, VA, would be ideal, and maybe you've played there. I'd be more than happy to help contact the Birchmere or other venues if that would be helpful. Otherwise, I"ll hope to see you in concert in the not too distant future. I love your music and as a documentary filmmaker, myself, look forward to seeing your film. All best,
Marcy Pollan
Silver Spring, MD


text:
Office Mate
October 18th, 2011
It seems that every girl these days are getting tattoos. When will this trend end? Will it end? Why did Claire get one? "I am actually quite comfortable with my decision," Claire said. "I don't regret having it done. I've read that we Brits are rebellious and that's why so many British girls get a tat but that's not the reason I did it. A cheeky boy came up to me in a coffee bar and asked me if I would ever get one on my boob but I don't think I would go that far! It was a clever way to get me to talk about my tits. Actually he was quite complimentary so I did give him my phone number. He never did ring though." There is one advantage to the shapely blonde financial worker getting her name tatted on her mid-section. She doesn't need to introduce herself at the beach or when she's wearing a belly shirt.
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text:
Research Topics
Genomes and Genes
thromboxane b2
Summary: A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications194 found, 100 shown here
- Cyclooxygenase inhibitors and the antiplatelet effects of aspirinF Catella-Lawson
EUPENN Group of Investigators, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6084, USA
N Engl J Med 345:1809-17. 2001..Treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin...
- Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenaseR M McMillan
ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire
Br J Pharmacol 107:1042-7. 1992..In human and dog blood, ICI D2138 did not inhibit thromboxane B2 synthesis at a concentration of 500 microM, thus the selectivity ratio (cyclo-oxygenase: 5-lipoxygenase) was ..
- Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interactionJ P De La Cruz
Department of Pharmacology and Therapeutics, School of Medicine, University of Malaga, 29071 Malaga, Spain
Br J Pharmacol 137:1082-8. 2002..4. In conclusion, the effect of specific blockage of TxS together with blockage of membrane receptors for TxA(2) can surpass the effect of ASA in inhibiting the platelet-subendothelium interaction in flow conditions...
- Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholineGarrett J Gross
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisc 53226 3548, USA
Pharmacology 71:135-42. 2004..to establish inhibition of COX-2 (lipopolysaccharide-stimulated prostaglandin E2 formation) and COX-1 (serum thromboxane B2) in blood taken from dogs administered 1, 3, or 10 mg/kg naproxen or 15 mg/kg SC-58236...
- Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart diseaseZhengyuan Xia
Department of Anesthesiology, Affiliated Renmin Hospital, Wuhan University, PR China
J Thorac Cardiovasc Surg 126:1404-10. 2003..The relationship between endothelin-1 and the endothelium-derived prostacyclin (prostaglandin I2) and thromboxane A2 postoperatively is also investigated...
- Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure?Rocio Gonzalez-Conejero
University of Murcia, Centro Regional de Hemodonacion, Ronda de Garay S N, 30003, Murcia, Spain
Stroke 36:276-80. 2005..The widespread use of aspirin requires clarification of the aspirin resistance phenomenon. Most studies on this field are focused on patients which may affect the action of aspirin...
- 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophilsEva Böhm
Department of Experimental and Clinical Pharmacology, Medical University Graz, A 8010 Graz, Austria
J Biol Chem 279:7663-70. 2004..Given its production in the allergic lung, antagonism of the 11-dehydro-TXB(2)/CRTH2axis may be of therapeutic relevance...
- In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 productionM Cattaneo
A Bianchi Bonomi Hemophilia and Thrombosis Center, I R C C S Maggiore Hospital, Italy
Thromb Res 62:717-24. 1991..3 picolyl-4-methoxy-isophthalamide) on human platelet aggregation, the release reaction and the production of thromboxane B2 (TxB2) induced by several platelet agonists...
- Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertensionP C Guimarães
Vascular Surgery Service, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brazil
Sao Paulo Med J 116:1721-6. 1998To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH).
- Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulusWendy I Baltzer
Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4474, USA
Am J Vet Res 67:78-83. 2006To measure 11-dehydro-thromboxane B2 (11-dTXB2) in urine of healthy control dogs, dogs undergoing ovariohysterectomy, and dogs with gastric dilatation-volvulus (GDV) and assess the relationship between urinary 11-dTXB2 concentrations in ..
- Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmaticsM Kumlin
Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden
Am Rev Respir Dis 146:96-103. 1992..abstract truncated at 250 words)..
- Validation of immunoassays for the candidate renal markers C-reactive protein, immunoglobulin G, thromboxane B2 and retinol binding protein in canine urineBert E J Maddens
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Vet Immunol Immunopathol 134:259-64. 2010....
- Variable platelet response to aspirin and clopidogrel in atherothrombotic diseaseAndrew O Maree
Division of Cardiology, Harvard Medical School and Massachusetts General Hospital, Boston, Mass, USA
Circulation 115:2196-207. 2007
- Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinomaGeorge G Chen
Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong
Cancer Lett 234:193-8. 2006..In conclusion, our study demonstrates that the production of TXB(2) is increased in lung tumor tissues and that such an increase can result in lipid peroxidation which may be met by an elevation in Bcl-2 expression...
- Changes in crevicular fluid levels of interleukin-1 beta, leukotriene B4, prostaglandin E2, thromboxane B2 and tumour necrosis factor alpha in experimental gingivitis in humansP A Heasman
Dental School, University of Newcastle upon Tyne, England
J Periodontal Res 28:241-7. 1993..Crevicular fluid samples were assayed in quadruplicate for prostaglandin E2 (PGE2), thromboxane B2 (TxB2), leukotriene B4, interleukin-1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha) by RIAs or ..
- Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistanceAndrew L Frelinger
Center for Platelet Function Studies, Department of Pediatrics, UMass Memorial Medical Center, 55 Lake Ave N, Worcester, Massachusetts 01655, USA
Circulation 113:2888-96. 2006..Thrombotic events still occur in aspirin-treated patients with coronary artery disease...
- Platelet activation in obese women: role of inflammation and oxidant stressGiovanni Davi
Center of Excellence on Aging, G D Annunzio University Schools of Medicine and Pharmacy, Chieti, Italy
JAMA 288:2008-14. 2002..Obesity, in particular abdominal adiposity, is associated with increased cardiovascular morbidity and mortality through mechanisms possibly linking the metabolic disorder to platelet and vascular abnormalities...
- Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathwaysTsutomu Michibayashi
Clinical Pathophysiology, Division of Human Comprehensive Medicine, Graduate School of Medicine, Sapporo Medical University, Sapporo, Japan
J Atheroscler Thromb 12:154-62. 2005..Thus, it may be concluded that PAF-induced platelet aggregation participates in activation of the 12-LOX pathway and is accompanied by the release of vasodepressor nerve-stimulating substances from platelets...
- Significant effects of tipranavir on platelet aggregation and thromboxane B2 formation in vitro and in vivoJochen Graff
Pharmazentrum Frankfurt, Institute of Clinical Pharmacology at the Johann Wolfgang Goethe University Frankfurt, Germany
J Antimicrob Chemother 61:394-9. 2008..Recently, the FDA published a warning concerning intracranial haemorrhage in patients taking the HIV-1 protease inhibitor tipranavir co-administered with ritonavir...
- Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular eventsJohn W Eikelboom
Department of Medicine, University of Western Australia, Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
Circulation 105:1650-5. 2002..We studied whether aspirin resistance, defined as failure of suppression of thromboxane generation, increases the risk of cardiovascular events in a high-risk population...
- Aspirin resistance: definition, mechanisms and clinical read-outsC Patrono
University of Rome La Sapienza, Rome, Italy
J Thromb Haemost 1:1710-3. 2003
- Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assayM Feldman
Medical Service, Dallas Department of Veterans Affairs Medical Center, Texas 75216, USA
J Am Coll Cardiol 37:2036-41. 2001..We performed a placebo-controlled study to evaluate the effect of low-dose aspirin on serum C-reactive protein (CRP) levels...
- Aspirin resistanceJorge Rouvier
Circulation 106:e200-1; author reply e200-1. 2002
- Seasonal variation in parameters related to coronary heart disease risk in young menV Mustad
Graduate Program in Nutrition, Pennsylvania State University, University Park 16802, USA
Atherosclerosis 126:117-29. 1996..An understanding of these variations is important not oly for clinical evaluation and metabolic study design issues, but more importantly, to clarify their clinical significance with the seasonal incidence of CHD events...
- Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypassJ M Pearl
Division of Pediatric Cardiothoracic Surgery, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Ann Thorac Surg 68:1369-75. 1999Plasma thromboxane B2 (TXB2), leukotriene B4 (LTB4), and endothelin-1 (ET-1) levels increase on cardiopulmonary bypass (CPB)...
- Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention populationNauder Faraday
Division of Cardiac Surgical Intensive Care, Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Cardiol 98:774-9. 2006..aspirin resistance on several different platelet function assays, including the level of urinary 11-dehydro thromboxane B2 (Tx-M), platelet aggregation to arachidonic acid and adenosine diphosphate, and closure time on the platelet ..
- Can platelet function tests predict the clinical efficacy of aspirin?Hannelore Haubelt
Institute of Hemostaseology and Transfusion Medicine, Academic City Hospital, Ludwigshafen, Germany
Semin Thromb Hemost 31:404-10. 2005..Recent data demonstrate that none of the currently developed assays, including the PFA-100 system, are presently able to accomplish these objectives...
- Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritisC Zoja
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Kidney Int 60:653-63. 2001..We also examined the combination of MMF with a selective cyclooxygenase-2 (COX-2) inhibitor, DFU, based on previous findings of excessive renal production of COX-2-derived thromboxane A2 (TXA2) in lupus nephritis...
- Inhibition of platelet aggregation and expression of alpha granule membrane protein 140 and thromboxane B2 with pravastatin therapy for hypercholesterolemiaLi Ping Ma
Department of Internal Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Sciences, Guangzhou, People s Republic of China
J Assoc Acad Minor Phys 13:23-6. 2002..01), (2) ADP-induced maximum platelet aggregation (P < 0.01), (3) TXB2 or thromboxane B2 in platelets (P < 0.01), and (4) expression of GMP-140 or granule membrane protein-140 (P < 0.01)...
- Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular diseaseAndrew O Maree
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
J Am Coll Cardiol 46:1258-63. 2005..We investigated whether use of low-dose enteric-coated (EC) aspirin for secondary prevention of cardiovascular events has sufficient bioavailability to achieve complete platelet cyclooxygenase (COX) inhibition in all individuals...
- Platelet activating factor and thromboxane B2 production after cardiopulmonary bypassD M Ansley
Department of Anesthesia and Surgery, Vancouver Hospital, British Columbia, Canada
J Invest Surg 10:87-95. 1997..The purpose of this study was to investigate the relationships among production of PAF, thromboxane B2 (T alpha B2), and cardiopulmonary sequelae in patients undergoing coronary artery bypass graft surgery (CABGS)...
- Propofol has both enhancing and suppressing effects on human platelet aggregation in vitroH Hirakata
Department of Anesthesia, Kyoto University Hospital, Japan
Anesthesiology 91:1361-9. 1999..In contrast, there is conflicting information regarding the effect of propofol on platelet function. The present study was designed to clarify the effects of propofol on platelet function and the mechanisms underlying these effects...
- Escherichia coli lipopolysaccharide potentiation and inhibition of rat neonatal microglia superoxide anion generation: correlation with prior lactic dehydrogenase, nitric oxide, tumor necrosis factor-alpha, thromboxane B2, and metalloprotease releaseA M Mayer
Midwestern University, Chicago College of Osteopathic Medicine, Department of Pharmacology, Downers Grove, Illinois 60515, USA
Shock 11:180-6. 1999..O2- generation; 3-10 ng/mL LPS caused nitric oxide, tumor necrosis factor-alpha (TNF-alpha), thromboxane B2 and matrix metalloproteinase-9 release although partially inhibiting ensuing phorbol-12 myristate 13-acetate-..
- Ibuprofen therapy in experimental porcine gram-negative septic shockM P Griffin
Department of Pediatrics, University of Texas Medical Branch, Galveston
Resuscitation 22:75-83. 1991..4 h in the benzyl alcohol group and 15.7 +/- 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs...
- Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disordersMerja Vainio
Department of Obstetrics and Gynecology, Hyvinkaa Hospital, Hyvinkaa, Finland
Acta Obstet Gynecol Scand 83:1119-23. 2004..The aim of this study was to investigate the prostanoid production in pregnancies at high risk for hypertensive disorders, and the effect of low-dose acetylsalicylic acid (ASA) on prostanoids...
- p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivoCristina Luceri
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Br J Nutr 97:458-63. 2007..in plasma antioxidant activity, measured as ferric reducing ability of plasma, and with the reduction of thromboxane B2 production...
- Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivoN P Dowd
Department of Anaesthesia and Intensive Care, Beaumont Hospital, Dublin, Ireland
J Clin Invest 108:585-90. 2001..In contrast, administration of a COX-1 inhibitor SC560 at a dose that reduced serum thromboxane B2 by more than 80% did not prevent the doxorubicin-induced increase in prostacyclin generation...
- D-003, a potential antithrombotic compound isolated from sugar cane wax with effects on arachidonic acid metabolitesV Molina
Center of Natural Products, National Center for Scientific Research, Cubanacan, Havana, Cuba
Prostaglandins Leukot Essent Fatty Acids 67:19-24. 2002..The present results support that these effects of D-003 on AA metabolites could explain, at least partially, its antiplatelet and antithrombotic effects...
- Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenaseJiiang Huei Jeng
Laboratory of Dental Pharmacology and Toxicology, Graduate Institute of Clinical Dental Science, National Taiwan University, Taipei, Taiwan
Free Radic Biol Med 32:860-71. 2002..AN extract (1 and 2 mg/ml) stimulated rabbit platelet aggregation, with induction of thromboxane B2 (TXB2) production...
- Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteersKeith D Wilner
Pfizer Global Research and Development, San Diego, California 92122, USA
J Clin Pharmacol 42:1027-30. 2002..Therefore, these data indicate that celecoxib does not alter the effects of aspirin on platelet function...
- Effects of enteric-coated, low-dose aspirin on parameters of platelet functionA Van Hecken
Center for Clinical Pharmacology, University Hospital Gasthuisberg, Leuven, Belgium
Aliment Pharmacol Ther 16:1683-8. 2002..Aspirin is widely used as an anti-thrombotic drug; however, it has been suggested that enteric-coated formulations of aspirin may be less bioavailable and less effective as anti-thrombotic agents...
- Drug insight: aspirin resistance-fact or fashion?Andrew O Maree
Nat Clin Pract Cardiovasc Med 4:E1; author reply E2. 2007
- Enhanced platelet sensitivity to prostacyclin in patients in an active stage of Takayasu arteritisT Watanabe
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Thromb Res 104:77-83. 2001..The increase in sensitivity of the platelets to prostacyclin could be a compensatory mechanism against a decrease in the prostanoid production, presumably associated with endothelial dysfunction...
- Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirinS Guthikonda
Department of Cardiology, Emory University, Atlanta, GA 77030, USA
J Thromb Haemost 5:490-6. 2007..Immature (reticulated) platelets may modulate the antiplatelet effects of aspirin through uninhibited cyclooxygenase (COX)-1 and COX-2. Objectives: To evaluate the role of reticulated platelets in the antiplatelet effects of aspirin...
- Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in ratsFengyang Huang
Pharmacobiology Department, Cinvestav I P N, Mexico City, Mexico
J Cardiovasc Pharmacol 39:262-70. 2002..Also, no significant changes in ADP-induced thromboxane B2 formation in rat platelets or 6-keto-prostaglandin F 1alpha production from the abdominal aorta were observed ..
- 1A-779 attenuates angiotensin-(1-7) depressor response in salt-induced hypertensive ratsMohamed A Bayorh
Department of Pharmacology and Toxicology, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, GA 30310 1495, USA
Peptides 23:57-64. 2002....
- Genetic variation in cyclooxygenase 1: effects on response to aspirinMarc K Halushka
Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, USA
Clin Pharmacol Ther 73:122-30. 2003..Cyclooxygenase 1 (prostaglandin endoperoxide G/H synthase [PTGS1]) catalyzes the metabolism of arachidonic acid to prostaglandin H(2), which is subsequently metabolized to thromboxane A(2)...
- Moderation of the platelet releasate response by aspirinJudith A Coppinger
Department of Cell Biology, Scripps Research Institute, La Jolla, CA, USA
Blood 109:4786-92. 2007..These observations were confirmed for several cytokines using an antibody array approach...
- Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human bloodJ A Gonzalez-Correa
Department of Pharmacology and Therapeutics, School of Medecine, University of Malaga, Campus de Teatinos s n, Malaga, Spain
Platelets 16:171-9. 2005..plasma (PRP) with ADP, collagen or arachidonic acid as platelet inducers, and we measured the production of thromboxane B2, prostacyclin and nitric oxide...
- Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic ratsMarie Eve Rodrigue
Research Centre and Division of Nephrology, CHUQ, L Hôtel Dieu de Québec Hospital and Department of Medicine, Laval University, Quebec, Canada
Can J Physiol Pharmacol 83:467-75. 2005..These results stress the importance of preserving PGI2 production when treating rhEPO-induced hypertension under uremic conditions...
- Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016)Teresa Corazzi
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
J Pharmacol Exp Ther 315:1331-7. 2005....
- Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteersE Munsterhjelm
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Br J Anaesth 97:226-31. 2006..The authors studied the effect of a combination of i.v. parecoxib and acetaminophen on platelet function in healthy volunteers...
- Effects of DK-002, a synthesized (6aS,cis)-9,10-Dimethoxy-7,11b-dihydro-indeno[2,1-c]chromene-3,6a-diol, on platelet activityKi Seon Lee
Department of Preventive Pharmacy, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
Life Sci 78:1091-7. 2006....
- Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP productionJiiang Huei Jeng
Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan
Atherosclerosis 191:250-8. 2007..Sanguinarine may have therapeutic potential for treatment of cardiovascular diseases related to platelet aggregation...
- Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjectsJ Jermany
Exploratory Clinical Development, Novartis Pharma AG, WSJ 103 4 D, CH 4002 Basel, Switzerland
J Clin Pharmacol 45:1172-8. 2005..Urinary thromboxane and prostacyclin were unaffected by lumiracoxib. In conclusion, concomitant lumiracoxib did not interfere with the cyclooxygenase-1-mediated antiplatelet effects of low-dose aspirin...
- 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in plateletsChin Chung Wu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
Eur J Pharmacol 527:37-43. 2005..In a parallel manner, both arachidonic acid-induced thromboxane B2 and prostaglandin D2 formations were decreased in platelets treated with HPW-RX2...
- [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]Xiang Ying Kong
Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
Yao Xue Xue Bao 40:916-9. 2005..To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on thrombosis and platelet aggregation, and to explore its mechanism of action...
- Human pharmacology of naproxen sodiumMarta L Capone
Department of Medicine and Center of Excellence on Aging, School of Medicine, G D Annunzio University, Chieti, Italy
J Pharmacol Exp Ther 322:453-60. 2007..In conclusion, neither of the two naproxen doses mimed the persistent and complete inhibition of platelet COX-1 activity obtained by aspirin, but marked heterogeneity was mitigated by the higher dose of the drug...
- Dose- and time-dependent antiplatelet effects of aspirinChristina Perneby
Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
Thromb Haemost 95:652-8. 2006..5 mg aspirin daily, as evidenced by >98% suppression of serum thromboxane B2 and almost abolished arachidonic acid (AA) induced aggregation in PRP 2-6 h after dosing...
- Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patientsT Ohmori
Research Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
J Thromb Haemost 4:1271-8. 2006..In this study, we examined individual thromboxane biosynthesis and platelet aggregation in aspirin-treated patients, and whether the results of a platelet aggregation test influenced clinical outcomes...
- Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart diseaseMaria G Sciulli
Department of Medicine and Center of Excellence on Aging, G D Annunzio University, School of Medicine Gabriele d Annunzio University Foundation, Chieti, Italy
Clin Pharmacol Ther 80:115-25. 2006....
- Characterization of inhibition of platelet function by paracetamol and its interaction with diclofenac in vitroE Munsterhjelm
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 49:840-6. 2005..Clinically paracetamol is often used together with traditional NSAIDs, which are strong inhibitors of COX. We studied binding of paracetamol to COX and its action on platelet function together with diclofenac...
- Synergistic effect of D-003 and aspirin on experimental thrombosis modelsV Molina
Center of Natural Products, National Center for Scientific Research, Ave 25 and 158, Cubanacan, Havana 6880, Cuba
Prostaglandins Leukot Essent Fatty Acids 68:305-10. 2003..D-003 and ASA monotherapies reduced serum TxB(2) levels, whereas D-003, but not ASA, significantly increased 6 keto PgF1alpha levels...
- Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy menEwa Tuleja
Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland
Arterioscler Thromb Vasc Biol 23:1111-5. 2003..We tested the hypothesis that naproxen, contrary to rofecoxib, exerts antithrombotic effects...
- The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trialPhilip T Leese
Quintiles Phase I Services, Lenexa, Kansas, USA
J Clin Pharmacol 43:504-13. 2003..Platelet aggregation (to sodium arachidonate, collagen, and adenosine diphosphate), bleeding time, and serum thromboxane B2 (TxB2) concentrations were measured up to 8 hours postdose on Days 1 and 8...
- Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin bindingSheikh Arshad Saeed
Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Biochem Biophys Res Commun 353:915-20. 2007..This indicates that mammals have dual defense system, i.e., a specific immune system and non-specific Hp defense system...
- In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesisMaría Monsalud Arrebola
Department of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Malaga, Spain
J Cardiovasc Pharmacol 43:74-82. 2004..All three drugs impaired the platelet-subendothelium interaction under flow conditions. With thienopyridines, the presence of endothelium did not modify the percentage of the surface coated by platelets...
- Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjectsMarta L Capone
Department of Medicine and Center of Excellence on Aging, G D Annunzio University, School of Medicine, and G d Annunzio University Foundation, Chieti, Italy
Circulation 109:1468-71. 2004..The current controversy on the potential cardioprotective effect of naproxen prompted us to evaluate the extent and duration of platelet, monocyte, and vascular cyclooxygenase (COX) inhibition by naproxen compared with low-dose aspirin...
- Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activationSerenella Rotondo
Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Italy
Eur J Pharmacol 488:79-83. 2004..These results indicate that, at clinically relevant concentrations, licofelone exerts a potent antiplatelet effect mediated by the inhibition of cyclooxygenase-1 activity...
- Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanismYin ye Wang
Department of Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
Acta Pharmacol Sin 25:469-73. 2004..To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound...
- Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolismAlexandre Ghuysen
Hemodynamics Research Laboratory, University of Liege, Belgium
J Pharmacol Exp Ther 310:964-72. 2004..We conclude that in this animal model of acute pulmonary embolism, infusion of BM-573 reduced pulmonary vasoconstriction. As a result, right ventricular-vascular coupling values were maintained at a maximal efficiency level...
- Meloxicam does not affect the antiplatelet effect of aspirin in healthy male and female volunteersJoanne van Ryn
Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Str 65, 88397 Biberach, Germany
J Clin Pharmacol 44:777-84. 2004....
- Terms and conditions: semantic complexity and aspirin resistanceCharles H Hennekens
Department of Medicine and Epidemiology and Public Health, University of Miami School of Medicine, Miami, USA
Circulation 110:1706-8. 2004
- Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin?Leszek Markuszewski
Department of Interventional Cardiology, Cardiodiabetology and Cardiac Rehabilitation, Medical University of Lodz, University Hospital No 2, Lodz, Poland
Basic Clin Pharmacol Toxicol 98:503-9. 2006..Dyslipidaemia and chronic inflammatory states may promote suboptimal acetylsalicylic acid response in coronary artery disease patients...
- Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilizationM C Chang
Biomedical Science Team, Chang Gung Institute of Technology, Taoyuan, Taiwan
Br J Pharmacol 152:73-82. 2007..Betel leaf (PBL) is consumed by 200-600 million betel quid chewers in the world. Hydroxychavicol (HC), a betel leaf component, was tested for its antiplatelet effect...
- Effects of isradipine on platelet function in hypertension at rest and during exerciseP Fitscha
Department of Internal Medicine II, Policlinic, Vienna, Austria
Am J Hypertens 4:178S-180S. 1991..Systolic and diastolic blood pressures, platelet aggregation in response to adenosine diphosphate (ADP), serum thromboxane B2, and beta-thromboglobulin levels were significantly decreased (P less than ...
- Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) studyPaul A Gurbel
Sinai Center for Thrombosis Research, Hoffberger Bldg, Suite 56, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Circulation 115:3156-64. 2007..Our primary aim was to determine the degree of platelet aspirin responsiveness in patients, as measured by commonly used methods, and to study the relation of aspirin dose to platelet inhibition...
- Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirinAnetta Undas
Thromb Haemost 97:1056-8. 2007
- Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapySasidhar Guthikonda
Methodist DeBakey Heart Center, 6565 Fannin, F1090, Houston, TX 77030, USA
Thromb Haemost 100:83-9. 2008..04). In conclusion, platelets in AR subjects demonstrate increased basal sensitivity to submaximal stimulation, which could predict responses to antiplatelet therapy...
- Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findingsMarilena Crescente
Thromb Haemost 97:1054-6. 2007
- Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphismRoger Kranzhofer
Division of Cardiology, University of Heidelberg, Heidelberg, Germany
Platelets 17:163-9. 2006..However, a correlation exists to elevated eicosanoids generated by oxidative stress indicating COX-1-independent pathways for the generation of platelet activating molecules represent a potential cause for AR...
- Variable platelet response to aspirin in patients with ischemic strokeThomas Hohlfeld
Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat, Dusseldorf, Deutschland
Cerebrovasc Dis 24:43-50. 2007..It is not clear whether all of these patients with ischemic stroke respond normally to ASA or are hyporesponsive as assessed by inhibition of aggregation and thromboxane (TX) synthesis...
- Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertensionFrancisco X Eizayaga
Universidad Maimónides, Buenos Aires, Argentina
World J Gastroenterol 13:5065-70. 2007....
- Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophilsJ A Gonzalez-Correa
Department of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Campus de Teatinos s n, 29071 Malaga, Spain
Pharmacol Res 56:168-74. 2007..The variables recorded were maximum platelet aggregation intensity, thromboxane B2 (TxB2) production, and nitric oxide (NO) production (N=10 different samples in each type of experiment)...
- Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase CD M Skovronsky
Center for Experimental Therapeutics and The Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 276:17036-43. 2001..By contrast, Abeta release may represent secretion of preformed peptide and is totally independent of both COX and PKC activity...
- The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) studyJoseph DiChiara
Sinai Center for Thrombosis Research, Hoffberger Building, Suite 56, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Diabetes 56:3014-9. 2007..Diabetic patients may have a higher prevalence of platelet aspirin resistance than nondiabetic patients. Our goal was to analyze platelet aspirin responsiveness to various aspirin doses in diabetic and nondiabetic patients...
- Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbitsPancras C Wong
Discovery Biology, Bristol Myers Squibb Company, Pennington, New Jersey 08534, USA
J Cardiovasc Pharmacol 49:316-24. 2007..Moreover, modified IPA and P2Y12 receptor occupancy appear to better predict the magnitude of clopidogrel's efficacy compared with standard IPA, which may be a better predictor of BT...
- Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosisD Pratico
Center for Experimental Therapeutics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Blood 96:3823-6. 2000..Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosis. (Blood. 2000;96:3823-3826)..
- Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1Nauder Faraday
Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 115:2490-6. 2007..Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness...
- Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasoneJ A Mitchell
Department of Applied Pharmacology, National Heart and Lung Institute, London
Br J Pharmacol 113:1008-14. 1994..by the conversion of either endogenous or exogenous arachidonic acid to four metabolites, PGE2, PGF2 alpha, thromboxane B2 or 6-oxo PGF1 alpha measured by radioimmunoassay...
- Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in ratsWei Guo Dong
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
World J Gastroenterol 9:2533-8. 2003..To investigate the ameliorative effects of sodium ferulate (SF) on acetic acid-induced colitis and their mechanisms in rats...
- Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ cultureD Bishop Bailey
Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
Br J Pharmacol 121:125-33. 1997..system, we have determined the profile of COX (6-keto prostaglandin F1 alpha (6-keto PGF1 alpha), PGE2, thromboxane B2 (TXB2) and NOS (nitrite and nitrate) metabolites released over a period of 10 days from segments of rat aorta...
- Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitorD Riendeau
Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
Br J Pharmacol 121:105-17. 1997..The large increase in selectivity of DFU over indomethacin was also observed in COX-1 mediated production of thromboxane B2 (TXB2) by Ca2+ ionophore-challenged human platelets (IC50 > 50 microM and 4.1 +/- 1.7 nM, respectively). 3...
- Clinical and laboratory features, pathobiology of platelet-mediated thrombosis and bleeding complications, and the molecular etiology of essential thrombocythemia and polycythemia vera: therapeutic implicationsJan J Michiels
Department of Hematology, University Hospital Antwerp, Belgium
Semin Thromb Hemost 32:174-207. 2006..beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), and thrombomodulin (TM) levels, and increased urinary thromboxane B2 (TXB2) excretion, indicating platelet-mediated thrombotic processes...
- Prostaglandin H2 as an endothelium-derived contracting factor modulates endothelin-1-induced contractionH Asano
Department of Internal Medicine II, Nagoya University School of Medicine, Japan
J Hypertens 12:383-90. 1994..To investigate the possible involvement of prostaglandin H2, an endothelium-derived contracting factor in the rat aorta, in the development of the contraction induced by endothelin-1...
- Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchymaM A Giembycz
Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, London
Br J Pharmacol 108:824-32. 1993..with LTD4 (200 nM; EC100 for tension generation) stimulated a 150 and 70 fold increase in the elaboration of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) respectively, relative to that generated ..
- Studies of thromboxane B2, platelet factor 4, and fibrinopeptide A in bleeding-time blood of patients deficient in von Willebrand factor, platelet glycoproteins Ib and IIb-IIIa, and storage granulesH J Weiss
Department of Medicine Division of Hematology Oncology, St Luke s Roosevelt Hospital Center, New York, NY 10019
Blood 82:481-90. 1993The blood volumes and concentrations of thromboxane B2 (TxB2), platelet factor 4 (PF4), and fibrinopeptide A (FPA) were measured every 30 seconds in bleeding-time blood in normal subjects and in patients with idiopathic thrombocytopenic ..
- Augmented contraction of the human isolated coronary artery by sumatriptan: a possible role for endogenous thromboxaneA Maassen VanDenBrink
Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands
Br J Pharmacol 119:855-62. 1996..endothelin-1, but significantly reduced TxA2 production in coronary artery segments as judged by a decrease in thromboxane B2 (TxB2) from 4.77 +/- 0.98 to 1.38 +/- 0.36 ng g-1 2 h-1. 5...
- Intracoronary C5a induces myocardial ischemia by mechanisms independent of the neutrophil: leukocyte filters desensitize the myocardium to C5aR L Engler
Department of Medicine and Pathology, Veterans Administration Medical Center, San Diego, California 92161
FASEB J 5:2983-91. 1991..blood flow, myocardial contractile function (sonomicrometry), arterial/coronary venous blood PMN count, and thromboxane B2 (TxB2) levels were performed...
- Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet countsJ J Michiels
Hemostasis, Thrombosis and Vascular Research, Department of Hematology, University Hospital, Antwerp, Belgium
Pathol Biol (Paris) 51:167-75. 2003..higher levels of platelet activation markers beta-thromboglobulin, thrombomoduline and increased urinary thromboxane B2 excretion in thrombocythemia patients suffering from erythromelalgia...
- Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in ratsJ D Palombo
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Crit Care Med 27:1908-15. 1999....
Research Grants63
- Aspirin and Simvastatin--Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2006..We hypothesize that aspirin will decrease soluble P-selectin, serum thromboxane B2, and /Mhromboglobulin in patients with PAH compared to placebo over six months...
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2007..We hypothesize that aspirin will decrease soluble P-selectin, serum thromboxane B2, and /Mhromboglobulin in patients with PAH compared to placebo over six months...
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2009..We hypothesize that aspirin will decrease soluble P-selectin, serum thromboxane B2, and /Mhromboglobulin in patients with PAH compared to placebo over six months...
- NERVE BLOOD FLOW IN NORMAL AND ISCHEMIC PERIPHERAL NERVEPhillip Low; Fiscal Year: 1993..and superoxide dismutase (SOD) as indices of OFR damage and the biosynthesis by nerve in situ and in vitro of thromboxane B2 and 6-keto-PFG1 alpha will be used as indices of nerve eiscosanoids and nerve catecholamines will be measured...
- ER beta selective agonist coronary protection-menopauseR Hermsmeyer; Fiscal Year: 2005..In addition, C-Reactive Protein (CRP) in serum and thromboxane B2 in urine will be used as adverse indicators...
- IN VIVO INVESTIGATIONS USING MICRODIALYSIS SAMPLINGCraig E Lunte; Fiscal Year: 2010..First, the COX products prostaglandin E2 and thromboxane B2 and the LOX products the hydroxyeicosatetraenoic acids, 5-HETE and 15-HETE, and leukotriene B4 will be ..
- Mechanisms for Adverse Renal Effects from Lead ExposureVirginia Weaver; Fiscal Year: 2006..6 hemodynamic biomarkers (urinary prostaglandin E2, prostaglandin F2 alpha, 6-keto-prostaglandin F1 alpha, thromboxane B2, and total nitrites/nitrates and plasma renin level), and whether these biomarkers are associated with adverse ..
- DENTAL ATHEROSCLEROSIS RISK IN COMMUNITIESJames Beck; Fiscal Year: 1999..provide a biological burden of endotoxin (LPS, lipopolysaccharide) and inflammatory cytokines (especially thromboxane B2 [TxB2], interleukin-1 beta [Il-1b], prostaglandin E2 [PGE2] and tumor necrosis factor alpha [TNFa]) which ..
- ASPIRIN/FOLATE PREVENTION OF LARGE BOWEL POLYPSJohn Baron; Fiscal Year: 1999..We also propose to measure urinary thromboxane B2, and red blood cell and serum folate near the time of study completion...
- SYSTEMIC EFFECTS OF PERIODONTITISJames Beck; Fiscal Year: 2002..Sanguis. Gingival crevicular fluid will be collected for the quantitation of Prostaglandin E2 (PGE2) thromboxane B2 (TxB2), Interleukin-1B (IL-1B) and tumors necrosis factor a (TNFa)...
- INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAMEmelia Benjamin; Fiscal Year: 2003..monocyte chemotactic protein-1, tumor necrosis factor-alpha) and oxidative stress markers (8-epi-PGF 2alpha, thromboxane B2). The specific aims of this proposal are to: 1...
- Strategies for Efficient Routes to Bioactive SubstancesSteven Burke; Fiscal Year: 2006..Didemniserinolipid B, containing the 6,8-dioxabicyclo[3.2.1]octane skeleton common in bioactive agents; . Thromboxane B2-(TXBz)...


text: Distilled in Vietnam from the rare highly prized yellow-blossom variety of rice, this new small batch vodka is available in Original and Lychee flavors. The name "kai" accentuates the positive in cultures throughout Asia, translating as "pleasure" in Japanese and "happy gathering" in Chinese. KAI retains an age-old fermentation process prior to a multi-step distillation technique. The Original exhibits a delicate bouquet, with hints of spice, vanilla and tropical aromas. The Lychee has a sweet, rich flavor – smooth, complex and perfumed with notes of spice, rose and honey. Both varieties retail for $3O.


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Is it surprising that I've already checked my new gym? :)
I went to the Goodlife at Strandherd Crossing for the first time. It's a mere 5km from my new house and it's a beautiful facility. SCORE!
I checked the schedule, and there was a Body Combat class at 5h30.
If you've been reading my blog for a while you know that I'm not new to Body Combat, I've been attending that class for at least 4 years.
But the second I walked into this class it just felt different. The second the music started, and the instructor gave her opening remarks I knew it was going to be a great class.
I'm not a happy exerciser. I'm there to work. I'm there to sweat. I'm there to burn calories.
You know what though? During this class I actually smiled. A lot.
The instructor's energy was totally infectious. Her music selection was amazing. She was EXACTLY what I like in a fitness instructor, a combination of drill Sergeant with a bit motivational speaker tossed in.
And her back muscles? Gorgeous.
Throughout the class, I told myself that after the class I would go introduce myself and thank her for such an amazing class. Like I said, I've taken HUNDREDS of classes and have yet to be "wowed" like I was last night. I've never really chatted with an instructor after class, but I felt compelled to tell her how much I LOVED her class.
Just before we started our ab track, Denise humbly told us that she was being considered for Instructor of the Year in Ottawa. A title she most certainly deserves.
I've been having some slight anxiety issues about leaving my current club, as it's become like a little family to me. A sense of comfort if you will...but after taking Denise's class last night and even just being in the club itself, all my anxiety went away. As cheesy as it sounds, it felt like home.
I cannot wait to find out what other classes she teaches, because I will most certainly be in her "fan club".
Thank you Denise for making me work hard, for making me sweat, and for making me realize that exercise can be fun.
I'll be back to your classes. Often. :)
Question: Have you ever been wowed by an instructor? What makes a good group fitness instructor?


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Tag Archives: Outkast coachella
It's very good, as is to be expected.
Unless you live in like Billings, Montana, but in that case you are probably mostly likely used to being excluded from the lists of cities that
Hope springs eternal. The Outkast reunion does seem to be happening. Last night, Big Boi posted a series of pics to his Instagram account which


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Inside Passage Sights
Sons of Norway Hall
Sons of Norway Hall Review
Built in 1912, this large, barnlike structure that stands just south of the Hammer Slough is the headquarters of an organization devoted to keeping alive the traditions and culture of Norway. The window shutters are decorated with colorful Norwegian rosemaling designs. Outside sits a replica of a Viking ship that is a featured attraction in the annual Little Norway Festival each May. On the south side of the building is the Bojer Wikan Fisherman's Memorial, where deceased local fishermen are honored with a bronze statue.
- Address: 23 S. Sing Lee Alley, Petersburg, AK, 99833 | Map It
- Phone: 907/772–4575
- Location: Petersburg
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Product Recall: Voluntary recall of 260 cases of Velveeta Original Pasteurized Recipe Cheese Products. Click Here.
MIX graham crumbs, nuts, butter and 1/2 tsp. vanilla until well blended; press onto bottom and up side of 9-inch pie plate. Refrigerate until ready to use.
BEAT cream cheese and sugar in large bowl with mixer until well blended. Add hazelnut spread and remaining vanilla; mix well. Whisk stir in COOL WHIP; spoon into crust.
REFRIGERATE 4 hours.


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The U.S. Space & Rocket Center in partnership with Rocket City Mom is hosting the 2013 Learning Expo on Saturday, February 2nd, from Noon to 5:00 PM at the Davidson Center.
Parents and students alike will be able to explore all of their local educational options at the expo booths set up underneath the Saturn V Rocket. Representatives from local independent schools, preschools, and homeschooling organizations will be present to answer questions and give details about their programs. A representative from Huntsville City Schools will also be on hand to share information about the Magnet and IB programs offered by HCS.
Additionally, several local education related businesses and services will also be exhibiting. The Learning Expo is free and open to the public. Attendees should enter at the Davidson Center for Space Exploration Saturn V Hall.
WHY ATTEND - Meet leading private and independent schools and their students. - Learn how to find the right educational experience for your child. - Find out about the admissions process, when to apply, and what schools look for in potential students. - Determine your budget and receive information about scholarships and financial aid.
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Fresh off the sold-out 2013 Buddhist Geeks Conference in Boulder, CO, an announcement has already been made about 2014: the Geeks will gather again in Boulder for the Fourth Annual Conference, October 16-19. With Chris Dancy, Sofia Diaz, Hokai Sobol, Emily Horn, Vincent Horn, and Kelly Sosan Bearer already locked in as speakers, the organizers are promising "keynotes, live talks, unplugged sessions, #openpractice sessions, and roundtables", as well as "some surprising, new features," all in the interest of "exploring Buddhism, technology, and global culture."
If this sounds like your kind of powwow, "Early Adopter" tickets are now on sale at a steep discount, but only until December 30. Click here for conference and registration information.
Not sure if you can make it to the conference? No worries. One of the developments from the 2012 get-together was the creation of the online Buddhist Geeks Community, now several hundred strong. Discover it here, for interaction with like-minded dharma geeks all year long.


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Over the winter, Jesse took part in SB Nation's mock Winter Meetings in what is essentially a week of a flurry of emails regarding trade and free agent offers. How have his decisions played out so...
The Twins and Jason Kubel seem convinced that he will be the team's DH this season. But what if something goes wrong?
Spring training is upon us and the Twins are gearing up for the 2014 season. Although they're likely done shopping, perhaps there's still a few players available that could help the team this year.
The Twins seem committed to using Kurt Suzuki as their regular catcher to start 2014. Eric Fryer, Chris Herrmann, and Josmil Pinto are the three that will compete to be his backup next year, but...
After a flurry of activity to start the offseason, the Twins have gone silent lately, though they still have interest in multiple free agent pitchers. Is the allure of Masahiro Tanaka to blame, or...
Let's use some graphs to visualize how various Twins players rate with the five tools!
Even after signing Ricky Nolasco and Phil Hughes, the Twins have a great deal of work to do. The Winter Meetings is a good place to get things started for the rest of the off-season.
Twinkie Town reveals their final moves of the SB Nation Mock Winter Meetings, and reflects on the week-long exercise.
Jesse and the Mock Twins continue to be active, especially for starting pitching, in Day 3 of SB Nation's Mock Winter Meetings.
The Twins were very active on Day 2 of the SB Nation Mock Winter Meetings. How did they do? Read on.
With Day 1 of the SB Nation Mock Winter Meetings wrapped up, Twinkie Town's Jesse dishes on the happenings of the day for the Twins.
Need to know what will be happening when, baseball fans? Twinkie town has your answers. And a couple of translations.
Jesse runs through the Twins, position by position, to determine which areas of the team should be getting the most focus from the front office this winter. Starting pitching is one area, but what...
Examining Minnesota's three arbitration-eligible players and their places on the 2014 roster.
Warne examines some thirty-something hitters whom the Twins should consider targeting this offseason.
Last winter, Jesse played the part of Twins GM as SB Nation ran a simulation of the Winter Meetings. He made a few really good decisions, and a few bad ones. How did it turn out overall?
With the Twins targeting starting pitching this winter, is Josh Johnson one guy you'd be willing to see them chase down?
With the off-season just a couple of weeks away, now is the time to get learned up on a few of baseball's rules that came into effect last winter. Today, Jesse breaks down Major League Baseball's...
The Twins need starting pitching in 2014. But they also need to find a way to add a little offense. Jesse finds five right-handed hitters who pull for power, fitting the profile of Target Field.
The Twins need to find a new strategy to help them bring in free agent talent. With more money available than they've ever had before, the answer might just be: over-spend.
When it comes to the upcoming winter, the Minnesota twins will have a lot of money to spend. How much do they have on the books and what kind of resources will they have? Twinkie Town has more.
The Rule 5 draft is a great annual source of speculation, for any number of reasons. Twinkie Town looks forward to discuss which players the Twins must add to the 40-man roster in order to protect...
After the playoffs are finished in October, teams across baseball will be getting their 40-Man rosters in order for the winter. Here's how Jesse sees that process shaking down for the Minnesota Twins.
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Two truckers have been found dead in their semi trucks this week.
Both men were discovered at Five Star Trucking at 4380 Glenbrook Road in Willoughby.
Police tell 19 Action News both deaths appear to be natural.
On Monday, April 14, 44-year-old Richard Pulsipher of Utah was found dead in his parked rig. He was in the midst of driving his routes across country. Pulsipher was found by a manager.
On Wednesday, April 16, 49-year-old Anthony Satterfield was found dead in his semi by a friend.
The Lake County Coroner will perform autopsies on both men.
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text: This is a portfolio of the photographs made by artist Dustin Angell at the 2008 Sweet Chariot Music and Arts Festival on Swan's Island, Maine. Printed are over one hundred black and white images. They depict the on and offstage lives of the musicians and artists involved, along with their families and friends.


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Hit-and-Run Car Accident Causes Critical Injury Recently-retired Major League Baseball player Jim Edmonds was critically injured in a Los Angeles car accident, which officials say, involved a hit-and-run driver. According to a City News Service report, the major injury collision occurred on Victory Boulevard near Fulton Avenue the night of March 31, 2011. Officials say a dark colored sedan was heading west on Victory Boulevard when it struck a man who was walking on the street. Officials are still looking into whether the man was attempting to cross the street or walking along the side of the roadway. He was apparently a few feet away from the crosswalk. The driver left the scene. No further description of the suspect or vehicle is available. Anyone with information about this accident is asked to contact LAPD at 818-644-8000. My heart goes out to the critically injured victim of this hit-and-run car accident, who is apparently fighting for his life. I pray that he makes it through these injuries and goes on to make a complete recovery. He and his family will be in my thoughts and prayers. Leaving the Scene of a Car Accident Based on this news report, the dark colored sedan struck the pedestrian. The driver did not even stop to look at what happened. He or she simply sped away from the scene leaving the severely injured Edmonds lying on the roadway. California Vehicle Code Section 20001 (a) states: "The driver of a vehicle involved in an accident resulting in injury to a person, other than himself or herself, or in the death of a person shall immediately stop the vehicle at the scene of the accident." If you have any information about this incident, the driver or the suspect vehicle, please visit our dedicated hit-and-run website at www.hitandrunreward.com to find out how you can leave an anonymous tip and become eligible to receive a $1,000 reward. This website is a part of our effort to partner with the community and hold these hit-and-run drivers accountable. Pedestrian Accidents According to California Highway Patrol's 2008 Statewide Integrated Traffic Records System (SWITRS) 104 people died and 2,716 were injured in pedestrian accidents in Los Angeles. Also, countywide, pedestrian accidents claimed 214 lives and injured 4,985 people during the same year.
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Raymarine, Inc., a world leader in marine electronics, and Boston Whaler, the legendary manufacturer of unsinkable family fishing boats, today announced that Raymarine has been named the exclusive marine electronics supplier to Boston Whaler. Raymarine products are now factory-installed options on 18 of Boston Whaler's 2010 models, offering boaters the perfect pairing of performance and durability.
The two companies worked hand-in-hand to select the best combination of Raymarine multifunction displays, HD Digital radar, HD Digital fishfinders, autopilots and VHF radios that meet Boston Whaler's rigorous standards for total quality, absolute safety, outstanding performance and trouble-free operation. These products include Raymarine's:
- New C-Series Widescreen Multifunction Displays
- New A-Series Chartplotters and Fishfinders
- HD Digital Radar
- DSM300 HD Digital Sounder Modules
- ST70 Autopilot with the X-10 or X-30 course computer
- Ray49, Ray55 and Ray218 VHF Radios
- SR100 Sirius Satellite Weather Receiver
"Raymarine mirrors our long history of designing state-of-the-art, yet low-maintenance products, making this a valuable partnership for everyone, especially our loyal customers," said John Ward, President, Boston Whaler. "With a fully-networked electronics suite from Raymarine, our customers will experience even more enjoyment and peace of mind on the water."
The first model to feature Raymarine electronics is the all new 370 Outrage, the largest Boston Whaler to date, which combines the finest in fishing and comfort features in a spacious layout. This ultimate fishing machine is outfitted with two Raymarine C140W displays, the DSM300, HD Digital radar and the ST70 X-30 autopilot. The ergonomically correct center helm layout provides easy access to the electronics suite and includes a fold-down helm standing platform and electrically adjustable captain's seat for maximum comfort and control.
"Raymarine is honored to join the Boston Whaler family and be part of some of the most respected and well-built boats on the market," said Dave Bimschleger, President of Raymarine, Inc. "Like Boston Whaler, we're committed to engineering products that are durable and easy-to-use, multiplying the quality and reliability boaters have come to associate with both companies."
For more information about Boston Whaler's 2010 line featuring Raymarine electronics, please visit: www.whaler.com
About Raymarine
Raymarine, a world leader in marine electronics, develops and manufactures the most comprehensive range of electronic equipment for the recreational boating and light commercial marine markets. Designed for high performance and ease of use, the award-winning products are available through a global network of dealers and distributors. The Raymarine product lines include radar, navigation aids, instruments, fishfinders, communications, software and systems. Raymarine plc is listed on the London Stock Exchange. For more information about Raymarine in the USA call 1-603-881-5200 or visit www.raymarine.com.
About Boston Whaler
Founded in 1958 and headquartered in Edgewater, Fla., Boston Whaler is a business unit of Brunswick Corporation. Whaler is the leading manufacturer of unsinkable family fishing boats 11 to 37 feet. For more information on The Unsinkable LegendTM, please visit www.whaler.com.