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propionibacterium acnes
Summary: A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.
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Publications266 found, 100 shown here
- Propionibacterium acnesA L Perry
Biomedical Sciences, School of Life and Heath Sciences, Aston University, Birmingham, UK
Lett Appl Microbiol 42:185-8. 2006b>Propionibacterium acnes, a common skin organism, is most notably recognized for its role in acne vulgaris...
- Propionibacterium acnes contamination in lumbar disc surgeryA Carricajo
Bacteriology Department, CHU Hospital Bellevue Saint Etienne, France
J Hosp Infect 66:275-7. 2007Previous studies have shown that Propionibacterium acnes may be responsible for low-grade infection of the intervertebral discs of patients with severe sciatica...
- A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigensAndrew McDowell
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
Microbiology 157:1990-2003. 2011..org/pacnes/) for Propionibacterium acnes based on the analysis of seven core housekeeping genes...
- Comparative genomics and transcriptomics of Propionibacterium acnesElzbieta Brzuszkiewicz
Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University of Gottingen, Gottingen, Germany
PLoS ONE 6:e21581. 2011The anaerobic gram-positive bacterium Propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. Recent work has indicated that evolutionary distinct lineages of P...
- Genome sequence of Propionibacterium acnes type II strain ATCC 11828Balazs Horvath
Institute for Plant Genomics, Human Biotechnology and Bioenergy, Bay Zoltan Foundation for Applied Research, Szeged, Hungary
J Bacteriol 194:202-3. 2012b>Propionibacterium acnes is an anaerobic Gram-positive bacterium that forms part of the normal human cutaneous microbiota and is occasionally associated with inflammatory diseases (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
- Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgarisTeruaki Nakatsuji
Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA
J Invest Dermatol 129:2480-8. 2009..not been demonstrated whether lauric acid can be used for acne treatment as a natural antibiotic against Propionibacterium acnes (P. acnes), which promotes follicular inflammation (inflammatory acne)...
- Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacteriumMariko Negi
Department of Human Pathology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
Mod Pathol 25:1284-97. 2012..b>Propionibacterium acnes is the only microorganism, however, found in sarcoid lesions by bacterial culture...
- Propionibacterium acnes: infection beyond the skinAlexandra Perry
Eurofins Agroscience Services Ltd, Slade Lane, Wilson, Melbourne, Derbyshire, DE73 8AG, UK
Expert Rev Anti Infect Ther 9:1149-56. 2011b>Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P...
- Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acneHans B Lomholt
Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
PLoS ONE 5:e12277. 2010The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin...
- The role of Propionibacterium acnes in acne pathogenesis: facts and controversiesClio Dessinioti
Department of Dermatology, Andreas Sygros Hospital, University of Athens, 5, I Dragoumi Street, 16121, Athens, Greece
Clin Dermatol 28:2-7. 2010We have come a long way since 1896, when it was first suggested that Propionibacterium acnes, found in acne lesions, was the cause of acne...
- Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogenyRolf Lood
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Sweden
BMC Genomics 12:198. 2011b>Propionibacterium acnes is a Gram positive rod inhabiting the human skin that also infects orthopaedic implants and is associated with acne vulgaris. Previously, one lytic bacteriophage, PA6, from P...
- Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue lightHelena Ashkenazi
Health Sciences Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
FEMS Immunol Med Microbiol 35:17-24. 2003b>Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It is known to naturally produce high amounts of intracellular porphyrins...
- Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnesJunko Minami
Department of Human Pathology, Tokyo Medical and Dental University, Japan
J Med Dent Sci 50:265-74. 2003Etiology of sarcoidosis remains unknown. A trigger factor from Propionibacterium acnes causes a cellular immune response in some sarcoid patients but not in nonsarcoid subjects...
- Beneficial or deleterious effects of a preexisting hypersensitivity to bacterial components on the course and outcome of infectionMarina Gumenscheimer
Max Planck Institut fur Immunbiologie, 79 108 Freiburg, Germany
Infect Immun 70:5596-603. 2002Priming with heat-killed Propionibacterium acnes enhances the sensitivity of mice to lipopolysaccharide (LPS) and other biologically active bacterial components. We show that P...
- A new phylogenetic group of Propionibacterium acnesAndrew McDowell
School of Medicine and Dentistry, Queen s University, Belfast BT12 6BN, UK
J Med Microbiol 57:218-24. 2008Immunofluorescence microscopy-based identification of presumptive Propionibacterium acnes isolates, using the P. acnes-specific mAb QUBPa3, revealed five organisms with an atypical cellular morphology...
- Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responsesJenny Kim
Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
J Immunol 169:1535-41. 2002One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes; yet, the molecular mechanism by which P. acnes induces inflammation is not known...
- Histone H4 is a major component of the antimicrobial action of human sebocytesDong Youn Lee
Division of Dermatology, University of California San Diego and VA San Diego Healthcare Center, San Diego, California, USA
J Invest Dermatol 129:2489-96. 2009..aureus and Propionibacterium acnes. In addition, histone H4 enhanced the antimicrobial action of free fatty acids in human sebum...
- Characterization of Propionibacterium acnes isolates from sarcoid and non-sarcoid tissues with special reference to cell invasiveness, serotype, and trigger factor gene polymorphismAsuka Furukawa
Department of Human Pathology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
Microb Pathog 46:80-7. 2009Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism so far isolated from sarcoid lesions. To examine whether P...
- In situ localization of Propionibacterium acnes DNA in lymph nodes from sarcoidosis patients by signal amplification with catalysed reporter depositionTetsuo Yamada
Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
J Pathol 198:541-7. 2002Sarcoidosis is a systemic granulomatous disease of unknown aetiology. Many genomes of Propionibacterium acnes and P. granulosum have been detected in lymph nodes from patients with sarcoidosis...
- Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosisIkuo Ishige
Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan
Sarcoidosis Vasc Diffuse Lung Dis 22:33-42. 2005In studies of the unknown etiology of sarcoidosis, Propionibacterium acnes (a possible agent) was found in the lungs and lymph nodes of many sarcoidosis patients and some control subjects. P...
- Modulation of integrins and filaggrin expression by Propionibacterium acnes extracts on keratinocytesV Jarrousse
INSERM U601, 9 quai Moncousu, 44093 Nantes Cedex 01, France
Arch Dermatol Res 299:441-7. 2007b>Propionibacterium acnes plays an important role in the pathogenesis of acne and it is established that this bacteria is involved in the induction and maintenance of the inflammatory phase of acne...
- Propionibacterium acnes and Staphylococcus epidermidis isolated from refractory endodontic lesions are opportunistic pathogensSadia A Niazi
Dental Institute, King s College London, London, England
J Clin Microbiol 48:3859-69. 2010..from 20 refractory endodontic lesions (9 with abscesses and 11 without abscesses) were determined, and Propionibacterium acnes and Staphylococcus epidermidis were among the most predominant organisms...
- Genetic diversity of Propionibacterium acnes strains isolated from human skin in Japan and comparison with their distribution in EuropeItaru Dekio
Skin Microbe Laboratory, Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Japan
J Med Microbiol 61:622-30. 2012b>Propionibacterium acnes, a commensal of human skin, is also an opportunistic pathogen of common acne and certain infectious diseases...
- An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strainsAndrew McDowell
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
PLoS ONE 7:e41480. 2012The Gram-positive bacterium Propionibacterium acnes is a member of the normal human skin microbiota and is associated with various infections and clinical conditions...
- A microbial aetiology of acne: what is the evidence?B Shaheen
Department of Dermatology, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
Br J Dermatol 165:474-85. 2011..There is considerable evidence, circumstantial at best, which suggests that micro-organisms, particularly Propionibacterium acnes, are important in the pathogenesis of acne vulgaris. However, it is still unclear whether P...
- Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in miceTetsu Nishiwaki
Department of Molecular Preventive Medicine and Solution Oriented Research for Science and Technology, The University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Am J Pathol 165:631-9. 2004..We report here that extrapulmonary sensitization to Propionibacterium acnes, which is one of the candidates to date, induced pulmonary Th-1 granulomas mainly in the subpleural and ..
- Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutantsMeike Sörensen
Max Planck Institute for Infection Biology, Department of Molecular Biology, D 10117 Berlin, Germany
J Microbiol Methods 83:211-6. 2010..acnes. The here presented insertional mutagenesis approach will facilitate future studies on P. acnes...
- Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnesSandrine Tchaptchet
Max Planck Institute for Immunobiology, Freiburg, Germany
Eur J Immunol 40:2506-16. 2010b>Propionibacterium acnes is a human commensal but also an opportunistic pathogen. In mice, P. acnes exerts strong immunomodulatory activities, including formation of intrahepatic granulomas and induction of LPS hypersensitivity...
- Complete genome sequences of three Propionibacterium acnes isolates from the type IA(2) clusterAndrea Vörös
Bay Zoltán Nonprofit Ltd, Szeged, Hungary
J Bacteriol 194:1621-2. 2012b>Propionibacterium acnes is an anaerobic Gram-positive bacterium that has been linked to a wide range of opportunistic human infections and conditions, most notably acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
- Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cellsLina Fassi Fehri
Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
Int J Med Microbiol 301:69-78. 2011..Recent work has detected the anaerobic Gram-positive bacterium Propionibacterium acnes in cancerous prostates, but with wide-ranging detection rates...
- TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytesKenshi Yamasaki
Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
J Invest Dermatol 131:688-97. 2011..These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea...
- Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnesMullika Traidej Chomnawang
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand
Fitoterapia 78:401-8. 2007The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. P...
- Rapid detection and quantification of PropionibacteriaceaeP Goldschmidt
Laboratoire du Centre National d Ophtalmologie des Quinze Vingts, 28 rue de Charenton, Paris, France
Br J Ophthalmol 93:258-62. 2009..The PCR cycling programme consisted of one cycle at 95 degrees C, 20 s and 45 cycles at 95 degrees C, 3 s and 30 s at 60 degrees C. DNA extraction yields were assessed in the same tube...
- Resveratrol inhibition of Propionibacterium acnesJohn J Docherty
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
J Antimicrob Chemother 59:1182-4. 2007To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth.
- An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control studyA C Jahns
Department of Medical Biosciences Pathology, Umea University, Umeå S 90185, Sweden
Br J Dermatol 167:50-8. 2012Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne.
- Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnesMogens Kilian
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
J Clin Microbiol 50:1158-65. 2012b>Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals...
- Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnesS Ramstad
Department of Physics, Norwegian University of Science and Technology, Dragvoll, Norway
J Photochem Photobiol B 40:141-8. 1997..We have investigated whether or not similar changes can be induced in prokaryotes. The skin bacterium Propionibacterium acnes was sensitized using protoporphyrin IX (PP IX) or 5-aminolevulinic acid (ALA)...
- Propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-alpha in human dermal fibroblastsJee Young Choi
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea
J Invest Dermatol 128:846-54. 2008b>Propionibacterium acnes (P. acnes) is a commensal microorganism found in sebum-rich skin and plays a role in acne inflammation by stimulating keratinocyte to produce a number of proinflammatory cytokines. However, the role of P...
- Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expressionTeruaki Nakatsuji
Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
J Invest Dermatol 130:985-94. 2010..The supernatant of FFA-incubated sebocyte culture showed antimicrobial activity against Propionibacterium acnes, whereas the enhanced antimicrobial activity of human sebocytes was neutralized by anti-hBD-2 IgG...
- Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnesRolf Lood
Department of Clinical Sciences, Division of Infection Medicine, BMC B14, Lund University, SE 221 84 Lund, Sweden
BMC Microbiol 8:139. 2008b>Propionibacterium acnes is a commensal of human skin but is also known to be involved in certain diseases, such as acne vulgaris and infections of orthopaedic implants...
- Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responsesJenny Kim
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, USA
Dermatology 211:193-8. 2005..One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes; yet, the molecular mechanism by which P. acnes induces inflammation is not known...
- Pathogenesis of acneM Toyoda
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Med Electron Microsc 34:29-40. 2001..of sebaceous gland secretion by androgens, and microbial colonization of pilosebaceous units by Propionibacterium acnes, which promotes perifollicular inflammation...
- Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapyUta Jappe
Department of Dermatology and Venereology, University of Heidelberg, Germany
Acta Derm Venereol 83:241-8. 2003..b>Propionibacterium acnes releases pro-inflammatory cytokines as well as antigens and mitogen(s), with cellular and non-cellular ..
- Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnesTsuyoshi Tanabe
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
Biochim Biophys Acta 1762:794-801. 2006..We found that intracellular Propionibacterium acnes, a possible causative agent of sarcoidosis, activated NF-kappaB in both NOD1- and NOD2-dependent manners...
- Induction of toll-like receptors by Propionibacterium acnesS Jugeau
INSERM U601, CHU, Pl A Ricordeau, 44095 Nantes, France
Br J Dermatol 153:1105-13. 2005The bacterium Propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity...
- Cloning of a new cytokine that induces IFN-gamma production by T cellsH Okamura
Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
Nature 378:88-91. 1995..Administration of anti-IGIF antibodies prevents liver damage in mice inoculated with Propionibacterium acnes and challenged with lipopolysaccharide, which induces toxic shock...
- The complete genome sequence of Propionibacterium acnes, a commensal of human skinHolger Bruggemann
Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
Science 305:671-3. 2004b>Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation...
- In vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against Propionibacterium acnes, Candida albicans, and Trichomonas vaginalisChieh Yu Pan
Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan
Peptides 30:1058-68. 2009..We studied the in vitro activities of epinecidin-1(22-42), csSALF(55-76), and lsSALF(55-76) against Propionibacterium acnes, Candida albicans, and Trichomonas vaginalis...
- Proteomic identification of secreted proteins of Propionibacterium acnesCarsten Holland
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
BMC Microbiol 10:230. 2010The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a ..
- Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnesDong Youn Lee
J Invest Dermatol 128:1863-6. 2008
- Skin microbiota: a source of disease or defence?A L Cogen
Department of Bioengineering, Division of Dermatology, School of Medicine, University of California, San Diego, CA, USA
Br J Dermatol 158:442-55. 2008..Specifically, the review will discuss our current understanding of the cutaneous microbiota as well as shifting paradigms in the interpretation of the roles microbes play in skin health and disease...
- Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgarisTeruaki Nakatsuji
Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, USA
PLoS ONE 3:e1551. 2008..people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P...
- Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolatesA Holmberg
Department of Clinical Sciences, Division of Infection Medicine, Lund University, 221 84 Lund, Sweden
Clin Microbiol Infect 15:787-95. 2009b>Propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis infection. Bacterial biofilm formation is central in the pathogenesis of infections related to foreign material, and P...
- MALDI-TOF MS fingerprinting facilitates rapid discrimination of phylotypes I, II and III of Propionibacterium acnesElisabeth Nagy
Hungarian Anaerobe Reference Laboratory, Institute of Clinical Microbiology, University of Szeged, 6725 Szeged, Semmelweis u 6, Hungary
Anaerobe 20:20-6. 2013..b>Propionibacterium acnes is frequently referred to as an anaerobic skin commensal of relatively low pathogenicity...
- Propionibacterium acnes-induced hepatic granuloma formation is impaired in mice lacking tetraspanin CD9Hiroyuki Yamane
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
J Pathol 206:486-92. 2005..When intrahepatic granulomas were induced by intravenous injection of Propionibacterium acnes, hepatocyte CD9 was extensively upregulated, while inflammatory cells constituting granulomas were mostly ..
- Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammationTim N Mak
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
Cell Microbiol 14:1720-33. 2012The contribution of the human microbiota to health and disease is poorly understood. Propionibacterium acnes is a prominent member of the skin microbiota, but is also associated with acne vulgaris...
- Draft genome sequence of an antibiotic-resistant Propionibacterium acnes strain, PRP-38, from the novel type IC clusterAndrew McDowell
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
J Bacteriol 194:3260-1. 2012b>Propionibacterium acnes, a non-spore-forming, anaerobic gram-positive bacterium, is most notably recognized for its association with acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
- Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidisMi Sun Kang
Department of Microbiology, School of Medicine, Chonnam National University, Gwangju, 501 746, Republic of Korea
J Microbiol 50:137-42. 2012While it is generally accepted that Propionibacterium acnes is involved in the development of acne, other bacteria including Staphylococcus epidermidis have also been isolated from the acne lesion...
- Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infectionRoger Bayston
Biomaterials Related Infection Group, School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK
J Antimicrob Chemother 60:1298-301. 2007b>Propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. Biofilm development by this organism has recently been demonstrated...
- Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonizationItai Sharon
Department of Earth and Planetary Science, UC Berkeley, Berkeley, California 94720, USA
Genome Res 23:111-20. 2013..At the species level, we observed the decline of an early-colonizing Propionibacterium acnes strain similar to SK137 and the proliferation of novel Propionibacterium and Peptoniphilus species late ..
- A descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgeryKarim Saleh
Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Lund, Sweden
Dermatol Surg 37:1014-22. 2011..The pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors...
- The antimicrobial activity of liposomal lauric acids against Propionibacterium acnesDarren Yang
Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA
Biomaterials 30:6035-40. 2009This study evaluated the antimicrobial activity of lauric acid (LA) and its liposomal derivatives against Propionibacterium acnes (P. acnes), the bacterium that promotes inflammatory acne...
- The evolving role of Propionibacterium acnes in acneJ J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
Semin Cutan Med Surg 20:139-43. 2001b>Propionibacterium acnes is a member of the resident cutaneous flora. Sebaceous follicles involved in acne are characterized by the accumulation of abnormally desquamated corneocytes and excess sebum-the microcomedo...
- A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnesDebika Biswal Shinohara
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Prostate 73:1007-15. 2013..To study this potential link in an in vivo system, we developed a mouse model of long-term bacteria-induced chronic inflammation of the prostate using a human prostatectomy-derived strain of Propionibacterium acnes.
- Propionibacterium acnes infection induces upregulation of inflammatory genes and cytokine secretion in prostate epithelial cellsJohanna B Drott
Department of Clinical Microbiology Virology, Umea University, SE 901 87 Umea, Sweden
BMC Microbiol 10:126. 2010The immune stimulating bacterium Propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. To understand the pathogenesis of the earliest phase of this infection, we examined the P...
- Role of monocyte chemoattractant protein-1 in Propionibacterium acnes-induced pulmonary granulomatosisH Ichiyasu
First Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
Microsc Res Tech 53:288-97. 2001..we developed a model using sensitized rabbits for T cell-mediated pulmonary granulomatosis induced by Propionibacterium acnes (P...
- Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnesYuko Takenaka
Department of Dermatology, Tokyo Women s Medical University, Tokyo, Japan
J Dermatol 39:350-4. 2012..To assess growth inhibitory and bactericidal effects of glycolic acid on Propionibacterium acnes in vitro, we used an agar diffusion method and a time-kill method...
- Multilocus sequence typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimensTim N Mak
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Prostate 73:770-7. 2013..The pro-inflammatory anaerobe, Propionibacterium acnes, is ubiquitously found on human skin and is associated with the skin disease acne vulgaris...
- Quantitative PCR of Propionibacterium acnes DNA in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acneYuriko Miura
Fukasawa Dermatology Clinic, Kanagawa, Japan
J Med Dent Sci 57:65-74. 2010To elucidate whether people with hair follicles containing many Propionibacterium acnes cells are prone to acne, we developed a novel method to count the number of P. acnes in hair follicles...
- Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responsesKenshiro Tsuda
Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan
PLoS ONE 6:e29020. 2011..b>Propionibacterium acnes (P. acnes) is an aerotolerant anaerobic gram-positive bacteria that causes acne and inflammation...
- Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophilsA Jain
Department of Microbiology, King George s Medical College, Lucknow 226003, India
Dermatol Online J 8:2. 2002b>Propionibacterium acnes (P. acnes), an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing neutrophil chemotactic factors (NCF)...
- Clinical significance of Propionibacterium acnes recovered from blood cultures: analysis of 524 episodesHyun Jung Park
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Republic of Korea
J Clin Microbiol 49:1598-601. 2011Of 522 patients with Propionibacterium acnes bacteremia (PAB), 18 (3.5%) had clinically significant PAB. Of these 18 patients, 10 (55.6%) had hospital-acquired bacteremia and 6 (33...
- Modulatory effect of killed Propionibacterium acnes and its purified soluble polysaccharide on peritoneal exudate cells from C57Bl/6 mice: major NKT cell recruitment and increased cytotoxicityR Z Ananias
Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Scand J Immunol 65:538-48. 2007b>Propionibacterium acnes has been described as a potent adjuvant to immune responses in vitro and in vivo. Presently, we analysed the modulation of peritoneal exudate cells (PEC) by heat-killed P...
- Susceptibilities of Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepimeRobert Shames
Division of Infectious Disease, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042, USA
J Clin Microbiol 44:4227-8. 2006We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1...
- TNF-alpha hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected miceT Merlin
, Freiburg, Germany
J Endotoxin Res 7:157-63. 2001..Using Lps(n) BALB/c and Lps(d) BALB/c/l mice, primed with Propionibacterium acnes or infected with Salmonella typhimurium, we show that concurrently to hypersensitivity to LPS, a ..
- Propionibacterium acnes DNA detected in bronchoalveolar lavage cells from patients with sarcoidosisJun ichi Hiramatsu
Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
Sarcoidosis Vasc Diffuse Lung Dis 20:197-203. 2003The causes of sarcoidosis are unknown. Propionibacterium acnes is so far the only bacterium to be found in sarcoid lymph nodes. We attempted to detect P...
- Propionibacterium acnes biotypes and susceptibility to minocycline and Keigai-rengyo-toShuichi Higaki
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi 930 0194, Japan
Int J Dermatol 43:103-7. 2004b>Propionibacterium acnes is the predominant organism in acne lesions, but the sensitivity of different biotypes of P. acnes to therapeutic agents has seldom been reported.
- Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acidEva Rosberg-Cody
Teagasc, Moorepark Food Research, Biotechnology Centre, Fermoy, Co Cork, Ireland
Microbiology 153:2483-90. 2007The linoleic acid isomerase enzyme from Propionibacterium acnes responsible for bioconversion of linoleic acid to trans-10, cis-12 conjugated linoleic acid (t10, c12 CLA) was cloned and overexpressed in Lactococcus lactis and Escherichia ..
- Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 productionH Tsuji
First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
J Immunol 162:1049-55. 1999..was designed to investigate the role of IFN-gamma in LPS-induced liver injury following priming with Propionibacterium acnes. At 1 week after priming BALB/c mice with P...
- Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitisHiroshi Kitagawa
Exp Dermatol 20:157-8. 2011Atopic dermatitis (AD) is a chronic disease characterized by a polarized Th2 immune response. Propionibacterium acnes (P. acnes) has been shown to elicit strong Th1 immune responses. We hypothesized that the host immune response to P...
- Neolitsea aciculata essential oil inhibits drug-resistant skin pathogen growth and Propionibacterium acnes-induced inflammatory effects of human monocyte leukemiaSang Suk Kim
Department Department of Chemistry, Cheju National University, Ara l dong, Jeju 690 756, Korea
Nat Prod Commun 6:1193-8. 2011..NAE exhibited moderate to strong antibacterial activity against drug-susceptible and -resistant Propionibacterium acnes and Staphylococcus epidermidis, which are known as acne-causing bacteria. In addition, NAE reduced the P...
- Roles of CD14 in LPS-induced liver injury and lethality in mice pretreated with Propionibacterium acnesYoshihiro Shuto
Department of Immunonology and Allergy, Oita University Medical School, Hasama machi, Oita 879 5593, Japan
Immunol Lett 94:47-55. 2004The mechanism of the liver damage and lethality in Propionibacterium acnes (P. acnes)-LPS system remains obscure...
- Propionibacterium acnes brain abscess appearing 10 years after neurosurgerySarah M Kranick
Hospital of University of Pennsylvania, Department of Neurology, 3 W Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Arch Neurol 66:793-5. 2009To describe a case of Propionibacterium acnes infection arising 10 years after neurosurgery and to review the literature regarding similar cases and their treatment.
- Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgarisTeruaki Nakatsuji
Division of Dermatology, Department of Medicine, University of California, San Diego, California 92161, USA
J Invest Dermatol 128:2451-7. 2008b>Propionibacterium acnes is a key pathogen involved in the progression of inflammation in acne vulgaris. We examined whether vaccination against P. acnes suppressed P. acnes-induced skin inflammation. Inactivation of P...
- Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivoTeruaki Nakatsuji
Department of Medicine, Division of Dermatology, University of California, San Diego, CA, USA
Proteomics 8:3406-15. 2008..Unlike humans, most animals produce little or no triglycerides in hair follicles to harbor Propionibacterium acnes a fact that has encumbered the development of novel treatments for acne lesions...
- Protective effects of radix Rosa laevigata against Propionibacterium acnes and lipopolysaccharide-induced liver injuryRong rong He
School of Traditional Chinese Materia Medicine, Shengyang Pharmaceutical University, Shengyang, China
Biosci Biotechnol Biochem 73:1129-36. 2009We investigated the effects of an extract of Radix Rosa laevigata (R. R. laevigata) on Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS)-induced acute liver injury...
- Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgarisNatsumi Ishida
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
Microbiol Immunol 52:621-4. 2008Antibiotic susceptibilities of Propionibacterium acnes in Japan were determined. Erythromycin-resistance was found in 10.4% (5/48) of the strains, and four of these were cross-resistance to clindamycin...
- Propionibacterium acnes: an under-appreciated cause of post-neurosurgical infectionM Nisbet
Infectious Disease Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand
J Antimicrob Chemother 60:1097-103. 2007b>Propionibacterium acnes is increasingly recognized as a cause of post-neurosurgical infection. This review of patients with P...
- The Propionibacterium acnes genome: from the laboratory to the clinicTed Rosen
Dermatology, Baylor College of Medicine, Houston, TX, USA
J Drugs Dermatol 6:582-6. 2007The genome of Propionibacterium acnes, the microbe presumed to be at least partially etiologic for the development of acne, has recently been decoded...
- Inhibition of propionibacterium acnes by bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivariusWhitney P Bowe
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Drugs Dermatol 5:868-70. 2006We report the in vitro inhibition of Propionibacterium acnes (P. acnes) by a bacteriocin-like inhibitory substance (BLIS-like substance) produced by Streptococcus salivarius (S. salivarius)...
- Propionibacterium acnes as an etiological agent of arthroplastic and osteosynthetic infections--two cases with specific clinical presentation including formation of draining fistulaeB Soderquist
Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, Orebro, Sweden
Anaerobe 16:304-6. 2010..b>Propionibacterium acnes was isolated in multiple cultures in both cases...
- Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effectBong Seon Kang
Department of Dermatology, Kangnam St Mary s Hospital, Seoul 137 040, Republic of Korea
J Microbiol 47:101-9. 2009..antimicrobial activity against Gram-positive pathogens assayed, especially the highest activity against Propionibacterium acnes. The antimicrobial substance was purified and verified as a bacteriocin (named ESL5) of E...
- Effect of adjunctive treatment with intravenously administered Propionibacterium acnes on reproductive performance in mares with persistent endometritisBarton W Rohrbach
Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
J Am Vet Med Assoc 231:107-13. 2007To determine whether treatment with a preparation of Propionibacterium acnes would improve pregnancy and live foal rates in mares with persistent endometritis.
- Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitroF H Al-Ghazzewi
Glycologic Limited, c o Glasgow Caledonian University, Glasgow, U K
Int J Cosmet Sci 32:139-42. 2010..of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro...
- The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cellsAnna Michalak-Stoma
Department of Clinical Immunology, Medical University of Lublin, Poland
Folia Histochem Cytobiol 46:535-9. 2008b>Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder...
- On the mechanism of a polyunsaturated fatty acid double bond isomerase from Propionibacterium acnesAlena Liavonchanka
Department for Plant Biochemistry, Albrecht von Haller Institute for Plant Sciences, Goettingen, Germany
J Biol Chem 284:8005-12. 2009The catalytic mechanism of Propionibacterium acnes polyunsaturated fatty acid isomerase (PAI) is explored by kinetic, spectroscopic, and thermodynamic studies...
- Heat shock proteins and inflammatory acne vulgaris: molecular cloning, overexpression and purification of a propionibacterium acnes GroEL and DnaK homologueM D Farrar
Skin Research Centre, Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK
FEMS Microbiol Lett 191:183-6. 2000b>Propionibacterium acnes is associated with inflammatory acne. The genes encoding two putative mediators of inflammation, the heat shock proteins GroEL and DnaK, were cloned from this organism and sequenced...
- Propionibacterium acnes resistance: a worldwide problemE A Eady
University of Leeds, Leeds, UK
Dermatology 206:54-6. 2003Antibiotic therapy directed against Propionibacterium acnes has been a mainstay of treatment for more than 40 years. Despite years of widespread use of systemic tetracyclines and erythromycin, change in P...
- Antibiotic resistance of Propionibacterium acnes in acne vulgarisJil K Swanson
Department of Dermatology, University of Pittsburgh Physicians, Pittsburgh, PA, USA
Dermatol Nurs 15:359-62. 2003..Antibiotics remain the most common prescribed agent for the treatment of acne. Improper use of antibiotics in the dermatological setting needs to be evaluated to prevent the increasing prevalence of antibiotic resistance...
- Increases in cytokine and antimicrobial peptide gene expression in horses by immunomodulation with Propionibacterium acnesElizabeth G Davis
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA
Vet Ther 4:5-11. 2003Immunomodulation with Propionibacterium acnes is used for prophylaxis of respiratory disease or in horses suffering from chronic pulmonary inflammation; however, the mechanism for this response is poorly understood...
- The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammationM Sharma
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
Phytother Res 25:517-21. 2011Acne is a chronic inflammatory disorder of skin follicles caused by the gram-positive bacterium Propionibacterium acnes. The possibility was investigated that a standardized preparation of Echinacea purpurea (Echinaforce®), with known ..
Research Grants46
- 5-Naphthoylsalicylanilides as improved anti-acne agentsRichard Evans; Fiscal Year: 2007..These include: 1) a broad spectrum of antibacterial activity, with exceptional activity against Propionibacterium acnes (a significant factor in the progression of acne) as well as other dermal pathogens such as ..
- GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNERobert Modlin; Fiscal Year: 2007..The increase in antibiotic-resistant strains of Propionibacterium acnes, the bacterium that contributes to the pathogenesis of acne, has hastened research for development of ..
- GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNERobert Modlin; Fiscal Year: 2009..The increase in antibiotic-resistant strains of Propionibacterium acnes, the bacterium that contributes to the pathogenesis of acne, has hastened research for development of ..
- Transfusion Medicine/Hemostasis Clinical Trials NetworkMark Brecher; Fiscal Year: 2007..Two TMH CTN protocols are ongoing at UNC, and it is the intention of the investigators at this site to support new network protocols in the future. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CRITIQUES ..
- Innate Immunity in Acne VulgarisJenny J Kim; Fiscal Year: 2010....
- Innate and Adaptive Immunity in Acne VulgarisJenny Kim; Fiscal Year: 2006..In inflammatory acne, Propionibacterium acnes plays a key role in eliciting host inflammatory response that is thought to be important for the ..
- Effect of Zinc in Attaching and Effacing E. coli InfectionJOHN K contact CRANE; Fiscal Year: 2010..Zinc inhibits the virulence of both of these groups of E. coli, and we wish to study zinc further to see if it could be used as a treatment for these infections. ..
- Host Cell Killing by EPEC: Central Role in PathogenesisJOHN CRANE; Fiscal Year: 2005..coli (RDEC-1) and rabbit EPEC (REPEC). ..
- Enteropathogenic and Toxigenic E.coli InteractionsJOHN CRANE; Fiscal Year: 2004..abstract_text> ..
- Effect of Zinc in Enteropathogenic E. coli InfectionJOHN CRANE; Fiscal Year: 2006..abstract_text> ..
- Immunological Secretomes of the Early Anthrax InfectionChun Ming Huang; Fiscal Year: 2010..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
- Secretomes captured in vivo via ultrafiltration probesChun Ming Huang; Fiscal Year: 2007..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. ..
- Anthrax vaccination by targeting spore germinationChun Ming Huang; Fiscal Year: 2005..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
- Immunological Secretomes of the Early Anthrax InfectionChun Ming Huang; Fiscal Year: 2007..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
- OCULAR MELANOMAPaul Finger; Fiscal Year: 2003..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
- Physical Activity, Aging and Immune FunctionJeffrey Woods; Fiscal Year: 2005..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..


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I just came off a very weird period. It started on Wednesday with brown blood for 2 days and then one day of very dark blood(sorry TMI) and then it ended yesterday. Only on day 3 did I have a flow but still not as much as usual. Now I have had sore breast for almost a week now, I get very tired at around 4-6pm every evening. That's what time we usually have dinner in my house so I am usually struggling to keep my eyes open. I don't know when I ovulate due to irregular periods but I am thinking I am around 13dpo. I took a test this morning and it came back negative.
I am also feeling mild cramping and bloated. My breast feel like they have grown so much...but my husband says he can't tell.
Does anyone have any insight? Has this happened to anyone? I feel like I am driving myself crazy. I guess I am just looking for some support.
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LAS VEGAS -- Government funding could come to a halt if the U.S. Senate doesn't pass a spending bill by midnight Saturday. One of the most controversial parts of the federal spending are all the earmarks, which include several for Nevada.
There's a long list of earmarks, or special spending projects, that could come to Nevada if the federal Omnibus Spending Bill is passed as written. From Nevada's National Guard to new senior centers, the list has a wide range of projects listed.
The Southern Nevada Regional Transportation commission would be given $2 million to help build an express bus from downtown to Boulder City.
"Two million dollars goes a long way. The project isn't just for an express transit route. There is a need to improve traffic signal coordination, and put some of the hardware, fiber optic communications systems in that entire corridor. We need to improve sidewalks," said Jacob Snow, RTC general manager.
Read a list of the Nevada earmarks
Metro police would have $700,000 to replace their old crime scene lab vehicle. Henderson police will get $600,000 to build a new training facility. Two million dollars would go to widening Highway 160 near Mountain Springs on the way to Pahrump. There is also more than $1 million for UNLV scientists to develop an unmanned aircraft for local disasters that is similar to the military's Predator Drone. The largest single grant would be $19 million for water infrastructure in rural Nevada towns.
Senator Harry Reid says he makes no apologies for bringing in earmark money for Nevada which he says will create jobs. Senator John Ensign says he will vote against it, partially because of earmark spending, even though he proposed nearly $100 million in earmarks within bill.
Reporter Nathan Baca: "Why not remove your support for those earmarks?"
Sen. Ensign: "I'm actually going to vote for the amendment, if we're allowed to offer an amendment, I'm going to vote for an amendment that strips all earmarks out of the bills."
Senator Ensign adds he proposed those earmarks to ensure Nevada get's its fair share from the federal pot of money. The democratic senatorial committee is calling Ensign's actions hypocritical, saying that he's trying to ban earmarks while writing them into the large spending bills.
If the Senate doesn't pass a spending bill by Saturday at midnight, a government shutdown is possible, according to Senator Reid's office.
Senator Ensign says Congress would pass a temporary spending bill before it got to that point.


text:
Chicago Symphony Orchestra Announces 2014-2015 Season - Tchaikovsky, Scriabin & More!
Chicago Symphony Orchestra (CSO) Music Director Riccardo Muti and Deborah F. Rutter, president of the Chicago Symphony Orchestra Association (CSOA), announce the programming for the CSO and Symphony Center Presents (SCP) 2014/15 season-the Orchestra's 124th season and Maestro Muti's fifth season as music director. Next season, Maestro Muti leads ten weeks of subscription concerts in four residencies with the Orchestra in Chicago, with appearances in September/October, January, February/March and June. In addition, he leads the Orchestra on a three- week tour of Europe in October and November, and in three performances at Carnegie Hall in January.
The wide range of programs conceived by Maestro Muti for the upcoming season highlights his rewarding relationship with the musicians of the CSO, at the same time supporting his commitment to bringing live music to the broadest possible audience as part of the CSO's Citizen Musician Initiative. He and the Orchestra continue to collaborate with some of today's most visionary artists to present dynamic programming that balances both well-known and less familiar repertoire.
Among Maestro Muti's programming for the 2014/15 season is a spotlight on two venerable Russian composers. By juxtaposing the symphonic works of Tchaikovsky and Scriabin, Maestro Muti explores the contrasts between these two composers who share a common heritage while owning distinctive styles. Maestro Muti has long been a passionate champion of Scriabin's music and is dedicated to performing not only his most famous works, but also scores that may be less recognizable to audiences.
A season-long focus on French composers traverses two centuries of Gallic culture from Berlioz to Boulez, whose 90th birthday is celebrated during this season. A three-week festival in May, entitled Reveries and Passions and led by Esa-Pekka Salonen, serves as a highlight, with a specific emphasis on 20th century French dramatic and operatic works.
The Austro-Germanic tradition, which lies at the heart of Western classical music, is represented throughout the 2014/15 season by masterworks of the core orchestral repertoire, including works by Bach, Mozart, Beethoven, Schubert, Brahms, Bruckner and Mahler.
The season also features the world premieres of commissioned works by Mason Bates and Anna Clyne in the culmination of their five years as Mead Composers-in-Residence.
Other highlights of the Orchestra's 2014/15 season include:
About Author
- Comcast SportsNet Bay Area Premieres ?Peruball: Jim Harbaugh in South America? on Today, Sept. 2 at 9 p.m. PT
- STAGE TUBE: First Look at FROZEN'S Elsa in ONCE UPON A TIME Season 4 Teaser
- Taylor Swift Set to Join THE VOICE Season 7
- Russo Brothers Talk Directing COMMUNITY Season 3 Premiere on YAHOO! and More
- Fox to Give THE GREATEST AMERICAN HERO a Reboot
- ARROW Adds SUPERNATURAL Alum to Season 3
- STAGE TUBE: "The World is Changing" in New DOWNTON ABBEY Season 5 Trailer
- THE WALKING DEAD to Feature Gay Character?
- Amazon To Bring Back Patrick Warburton in THE TICK?
- Melissa Rivers Opens Up: 'My Mother Would be Touched by the Tributes and Prayers'


text:
Is it flashing red light at School Street and Fairview Avenue? How about the myriad of signs along Slade Street? Or the intersection of Lexington and Belmont?
There are hundreds of stop signs in Belmont, but all too often, they are overlooked when drivers are in a rush.
We have all seen it and probably many would admit of a stop sign roll-through at one point in time.
Do you know of an intersection where a stop sign is frequently rolled through or ignored? Share the location in the comments section, below.


text:
Click on "Choose Category" and pick the category that you'd like to search through or explore.
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Or use our contact form and the FAQ.
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Ehm ... sieht zugegebenermaßen schlecht aus. ^^
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"Announcement was perfect. I altered each section to be worded the way I needed- adding words and actually changing what some sections said and covered. I fit everything I needed and wanted on the announcement. Pictures on back were an extra treat , good quality and free! Customer service is great, plenty of communication emails and very fast delivery."
"my daughters name in the lovely script caught the recievers attention it really is the perfect college announcemet and the price made it affordable for me"
"First of all, I ran into a snag while ordering these announcements and the CEO himself emailed me back and was very helpful and warm. I really appreciated that. I just received my order yesterday. It arrived very quickly and my order was AWESOME! It was better than I expected it to be. The quality was amazing! It looks so good! Excellent paper, great print quality and even the envelopes that come free with this order are a wonderful quality. The entire presentation of the order was above and beyond. I was so pleased. I will continue to use Tiny Prints for all of my printing needs. Thank you Tiny Prints!"
"My son was very happy with these graduation announcements. He had fun picking out the letter style. Very professional looking. The card-stock and envelope quality was excellent. Nice touch with the design on the back."
"Nice to have college they will be attending. Heavy quality paper, postcard like. Colors vibrant. Looks great with matching color envelopes and address labels!"


text:
When too much coding can kill you.
So now that I lured you in with that provocative title I suppose I need to clarify. Well it's true: too much coding can kill you, the real question is "what is the reason?" and the answer to that is; Chronic Stress.
So why write about this; well it's personal. You see: it happened to me, and I'm hoping to tell other people that it could happen to them too.
"Holy Smokes Batman, do you mean it takes years"
So what is Chronic stress. To quote Wikipedia: Chronic stress is the response to emotional pressure suffered for a prolonged period over which an individual perceives he or she has no control.
A few key observations:
- Chronic stress is prolonged stress experienced over a long time period, often years.
- There is a distinct physical effect on the body resulting in the continuous release of hormones meant to only be released for a temporary period of time.
- When you are in state of prolonged stress, you may not recognise it or if you do, feel that you cannot do anything about it.
The Human body is designed to deal with stress, provided it's temporary. When you are under stress your body releases hormones most notably Adrenalin and Cortisol. Adrenalin boosts your heart rate and energy supplies. Cortisol increases glucose in the bloodstream and increases the bodies ability to produce glucose and ability to repair tissue.
If you were to compare is to a car, Cortisol is like Nitrous, Adrenalin is your Turbo.
Now Nitrous is meant for a short boost, running it permanently is not great for your engine. Adrenalin and Cortisol is pretty much the same. If you run it permanently it's not great for your body.
Here are a few highlights of what you might expect when you suffer from Chronic Stress.
- Anxiety
- Irritability
- Recurring Insomnia
- Headaches
- Digestive disorders
- Depression
- Reliance on boosters such as caffeine
- Spikes and drops in energy at odd times
- Unexplained sudden weight gain
- Increase in illness and difficulty in recovering from illness
- Hypertension
- Cardiovascular disease.
Developers are like Soylent green.
So Developers - Just like Soylent Green - is people. In other words they are fallible limited creatures who have limitations in what they can do.The problem is that we often subject ourselves to increased stress, because of crazy timelines, unrealistic expectations (both by our employers and also by ourselves) and no small amount of ambition.This is complicated if you are a bit of an A-Type personality who has a tendency to take more and more things on.The sad part is the more you take and the higher your stress levels become, the less productive you become.
The writing is on the wall.
First chronic stress is not like a common cold, the symptoms develop after a long period of time and furthermore it's not something that really well understood.The result is that it's that this type of thing that creeps up on you, and before you know it you are chronically stressed out and now you need treatment.So here are some early warning signs that you can learn to identify it:
- Recurrent episodes of insomnia.
- Multiple people repeatedly tell you: "You look tired" or something similar.
- Your buttons suddenly start being pushed often and you find yourself getting more easily aggravated at things.
- You start becoming very negative and people tell you as much.
- You suddenly realise you haven't engaged in a personal hobby or done something you like in quite some time.
- You often have a headache and/or heartburn.
- You struggle to turn off work and/or you're always anxious about work.
- You often work overtime because it's the only time you can get "flow" due to the multitude of distractions in your environment.
Deal with it!.
There is quite a lot help out there with regards to reducing stress, but from a personal view there are a few things worth mentioning:
- Ultimately no one actually forces you to be stressed out, If you don't find a way to deal with it no one else will.
- Other people won't get it or recognise it unless they have first hand experience, you have to accept and deal with it yourself.
- Acknowledge your limits.
- Take stress seriously, it can damage your relationships, your career and your health.
- Don't be afraid to get professional help.
- Take that vacation.
- Be careful when you blur work and pleasure, Especially if one of your hobbies is writing code.
(Note: Opinions expressed in this article and its replies are the opinions of their respective authors and not those of DZone, Inc.)
James Lewis replied on Wed, 2014/06/04 - 8:49am
Your 'deal with it' section is insensitive and unhelpful.
Thank you so much for bringing this to developers, but your 'deal with it' advice is badly written when you have acknowledged a couple of paragraphs before that we are people. We are not problems to be solved and if you are the person experiencing chronic stress absolutely the hardest thing to do is find a comfortable way to start talking about it, to find help that works for you, and to stick with it and change what are probably deeply seated behaviours that are leading to your stress.
Also I can't believe that you haven't added the simple point that if you have been through this, and you see someone who looks like they're going through it, GO HELP THEM.
So, some advice on how to start that, from someone who also has been through this a few times:
- Don't worry! There are lots of people dealing with various forms of stress, anxiety and depression. There are things you can do about it, and it will go away. Even if it doesn't seem so it's likely most or all of the people around you just want you to be happy (even if they also need you to build something for them) and will support you in whatever steps you need to take to be happy.
- Talk to people, online, in real life. Try to get over the bump that you don't know quite what this thing is yet or how to describe it by starting with simple conversations in any media you feel comfortable with. It's ok that you don't know how to describe this feeling right now, or what the cause is, it will take some time to build up the vocabulary, and this is an iterative process.
- Do the simple stuff. Although medication (prescribed, bottled or smoked) can help with relief, it is not the solution. Whatever you can do in 'the basics' will help: sleep well, eat well, consume less caffeine, exercise, socialise.
- Work towards a long term solution. Generally in my experience this stuff takes time for everyone to fully work it out, and you will be using the lessons you learn during this process every day for the rest of your life to slowly tweak your behaviours and help make sure the stress doesn't come back. Take your time, find a good person to talk to. Learn the behaviours, find a long term solution that works for you.
Matthew Wagner replied on Wed, 2014/06/04 - 12:33pm
Also, search for software developer burnout. There are numerous stories out there on the subject. In some cases, more serious steps may be needed to correct the problem. A vacation may not be enough, but it may be a good start. A longer term break from the industry may also be helpful. If the problem has been building for many years, it may take a year or more to resolve. Exercise is the natural solution, but again, it alone may not be enough.
Mental Lion replied on Wed, 2014/06/04 - 1:32pm
I've read and I put into practice the fact that high performance workers are those that can work a number of hours and take small breaks of rest, several along the day. Small naps or meditations can avoid the accumulation of sodium and potassium imbalance ratio product of too much mental workout.
A brief period or nap or meditation (about 5 - 15min) can restore the ratio to normal resulting in mental refreshment. If you need help to take short naps at work try one of these audios online:
With this method you can work up to 12 hours per day for a good enough period of time.
Please share other ways to improve performance without put at risk out health. I heard about also about vibrating lights or even magnetic fields.
Julian Exenberger replied on Thu, 2014/06/05 - 6:29am in response to: James Lewis
Hi James.
My goal was no to be sensitive but rather to be jarring if that makes sense.
I wrote this from the perspective of my own experience which - believe me - was jarring and I am trying to portray that harsh reality.
In terms of dealing with there are tons of resources out there on how to deal with stress but IMHO all that is moot until you recognize the problem.
I only recognized the problem when I had already done the damage to myself and I still had to be held responsible for that damage I did.
Therefore my focus is to jar you into acknowledging the problems and dealing with the fallout.
Hope that makes sense
Kurt Reinke replied on Thu, 2014/06/05 - 1:15pm in response to: James Lewis
I never reply to these things, so this is really an exception for me. I read both your comments and Julian's reply below, and I see where you are both coming from. You also provide some excellent advice. I would, however, and not to take away from anything you wrote, just like to comment on Julian's "deal with it" comment a bit.
I was working in Dallas on a year long project, 16 hour days, away from home, kids in college, unrealistic deadlines, lots of pressure, etc., etc. My paycheck and our company's future depended on this project being a success. 9 months into the project I told my boss, project co-worker, and friend "J" that I couldn't handle all these negatives. After some friendly and understanding conversation his response was ... "Well ... you'll just have to deal with it".
At the time I too thought this was an insensitive and uncaring comment and I felt somewhat betrayed as his friend. I discussed it with my wife later that day and she thought so too and we decided together that I was going to start looking for another job; but in the interim I had to pay the bills and that meant I had to get back to work now and I had to "deal with it" ... whatever that meant.
Sometimes insensitive remarks can piss you off just enough to make you do things about your situation. That was certainly the case here and as I got back to work I took on a whole new way of approaching "my problem". I started to laugh and joke more and I started to practice "not caring".
After this project was over (and a huge success I might add), I later read an article by a golf writer who was watching Brad Faxon on the putting green. Brad Faxon was/is known as being a great putter. When he asked Brad what he was doing, Brad responded ... "I'm practicing not caring". I indeed laughed out loud when I read this; for if you've ever stood over a 2 foot to win a dollar bet on the final hole of a golf match against a friend, you'll know what that stress means. I guess that too was Brad's way of "dealing with" the pressure of tournament play.
I am your typical Type A personality and I had 6 bypasses. But I chalk that up more to heredity than my lifestyle; for now when I start feeling overstressed, I think of my friend's words and Brad Faxon and it makes me laugh and reminds me that I need to resume my practicing of "not caring".
"Dealing with it" takes many forms, you just have to figure out which is the best way for you. It's the NOT "dealing with it" that's the problem for many; it's not something we teach in school; but maybe we should. Thing is, we wouldn't understand it until it happened to us on a personal level.
BTW ... My putting is so much better now too ... and I'm currently boasting a 4.7 handicap index ... :) I find that no one cares but me if I miss a putt ... just as long as I don't crab about it and make their golf day a bad one ... :) And when I stand over that 2 footer on the last hole to win the match ... I stand back, take a deep breath, and just don't care ... :) It's not as easy as it sounds ... :) But surprisingly, for some reason, your end results and performance seem to improve.


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The fact that regular bee's honey, which everyone is familiar with, has medicinal properties has been known for thousands of years. But, until Beehive Essence entered the picture, no one knew that it was possible, through bees, to strengthen the attributes of medicinal plants! We've managed to produce healthy beehive products while maintaining the dosage through scrupulous scientific monitoring. The discovery of medicinal bees was sealed when bees fascinated our imagination, which especially excited us about their ability to maximize and strengthen the active materials in nectar. Our assumption, which has now been proven correct, was that if a system could be found through which it would be possible to control bees' nutrition, it would also be possible to control the composition of the active material of beehive products.The scientific staff at Beehive Essence arrived at a global breakthrough, which was the success in developing a unique nutritional formula for bees- based on medicinal plants. Each product has a unique formula. The plant extracts, which are the active ingredients, are fortified as they are processed in the bee's body. This phenomenon is significant when several plants are used in the same product, since the different plants form a synergy. This way, instead of the bees gathering nectar from different and coincidental sources, the bees which are part of the Beehive Essence beehives are nourished by an assigned mixture of "nectar" which is provided by medicinal plants. The result: healthy beehive products that provide an effective "solution" to a wide variety of health conditions and ailments.
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Switching from a Covington LA Bank to a Credit Union? Part 3 …
January 1, 2009 by admin
Filed under covington la bank, credit union, FCU Blog
Money is often a huge enticement for consumers to switch from a bank to a credit union. Money in the form of lower interest rates on loans, higher rates on savings, and lower fees.


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Show your romantic side with a Love Note this Valentine's Day
Posted: January 23, 2014|
BHF shops launch Love Notes campaign
Residents of the West Midlands will be relieved to learn that over three quarters (84%) of locals would choose a romantic gesture over an expensive gift this Valentine's Day – research from British Heart Foundation (BHF) shops revealed as they launch their annual Love Notes campaign.
In fact, people from the West Midlands are so keen on romantic gestures that 24% think a love letter or being taken out for dinner (23%) is the most romantic thing a partner could do for them.
West Midlands BHF shops provide the perfect way to romance that special someone this Valentine's Day by posting a heartfelt Love Note in West Midlands BHF shop windows until 16th February.
Just pop into your local BHF shop with a minimum £1 donation, every penny of profit raised goes on to fund life-saving research into the fight for every heartbeat.
Writing a Love Note will also help turn our shop windows red and support the BHF's flagship fundraising campaign, Ramp up the Red.
On the 7th February, the BHF is asking the great British public to pay £2, Ramp up the Red and help fight heart disease. Visit bhf.org.uk/red for more information on how to get involved.
Linda Puchala, Area Manager for the BHF, says: "It's interesting to see that 84% of people in the West Midlands prefer romantic gestures over expensive gifts.
Posting a Love Note in a West Midlands shop window is one of the easiest ways to express your love for that special someone whilst the small donation of £1 will help the BHF fund life-saving research into heart disease.
"Why not also Ramp up the Red on the 7th February. Our shops will be turning red so you're sure to find the perfect red item to help you ramp it up!"
This year celebrities such as Mollie King, Caroline Flack, Cilla Black, Eliza Doolittle, Hilary Alexander, Lee Mears and Lorraine Kelly have written a Love Note for BHF shops.
Call 0844 412 5000 or visit bhf.org.uk/shops to locate your local shop.


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Explore the fascinating science of animals with hands-on activities, crafts, a mystery, and more!
Gotham is overrun by villains and it's time to train. Prepare yourself in our training ground!
Come impersonate a snake, frog, mountain goat, and other animals as you make your way through the Animal Obstacle Course!
The world's most notorious criminal is on the run, and we need your help to catch her! Use your super sleuthing skills to decipher the clues about Carmen's whereabouts, and try to catch her before she steals the world's cities and landmarks!
Join us for a fun scavenger hunt in the community center. Limited to the first 20 participants.
Acompáñanos en una búsqueda de tipo "scavenger" en el centro comunitario. Cupo limitado de 20 participantes.
Familiarize yourself with the latest technology using our Wii gaming system. Limited to the first 20 participants. Usa nuestro equipo Wii y conoce lo último en la tecnología. Cupo limitado de 20 participantes.
All DPL locations closed 8/31, 9/1. More...
Building maintenance closures. More...
DPL Newsletters
All Social Media


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BeschreibungUse this tool to plan your future and become a successful individual. It uses an ancient algorithm to predict your success in terms of seven major categories: romance, finances, people skills, intellectual strength, business skills, travel options, and creativity. It also suggest your theme for a future date, your lucky metal/numbers as well as your lucky color and stone.
Please Note: This is a 15-day trial version. If you like this app, please purchase its unlimited version "Plan for a better Future" for just $10 - it is the same app but without any limitations.


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Osamu Tezuka Archives - Page 4 of 5 - Robot 6 @ Comic Book Resources
What Are You Reading?
Hello and welcome once again to What Are You Reading?, where the Robot 6 crew talk about the comics and graphic novels that they've been enjoying lately. Our special guest this week is comics journalist and critic Dirk Deppey of Journalista and The Comics Journal fame.
To see what Dirk and the Robot 6 crew have been reading lately, read on …
Straight for the art | OMAC meets Astro Boy
Artist Luis Chichón shows what OMAC might have looked liked if he was drawn by Osamu Tezuka. Via & via.
Your video of the day: Tezuka rave-up
The Shooting Star Project found this crazy animated video from the band Raver (circa 2008) featuring just about every Osamu Tezuka character around (though I didn't see Lamp anywhere). (via)
Thin wallets, fat bookshelves: A publishing news round-up
Two quick items of note:
1) Lissa "Kuriousity" Pattillo has sussed out what Vertical's next big Osamu Tezuka translation project is, following their ongoing release of Black Jack. Apparently it's Ayako, a work I'm unfamiliar with, but intially came out in 1972 and is described in detail over at the Anime News Network:
Jiro Tenge, the second son of what used to be an influential Japanese family, returns home after being a POW in an American camp during the Second World War. He finds his family corrupted by the terrible social aftereffects of the war. His elder brother, determined to keep what remains of the family patrimony after the Government's forced land reallocation, has prostituted his wife to his father to secure his blessing, while other members of Jiro's family have been drawn into similar corruption, and he himself is being forced to spy for the Americans after being broken as a POW. Now the family's youngest daughter Ayako will have to bear the brunt of the family's sins.
Judging by the page count, it looks like this will be a done-in-one volume similar to MW rather than separated into different volumes. According to Amazon, the book will be out in October. (via)
2) Paul Hornschemeier is currently working on a new collection of short stories entitled Forlorn Funnies Vol. 1. The book will come out in the fall from Fantagraphics. Here he is describing some of the contents:
Our principal concern of this volume, "Obvious Amenities," is Act One of the story of Edward Molson, salesman. After the untimely osprey-induced death of a co-worker, Molson is thrust into a cross-country speaking engagement, a chance to revisit youthful diversions, and a potential extra-marital love affair. But for now, he has to walk his wife's dog. Again.
What Are You Reading?
Like the Sunday newspaper, it's time once again for another round of What Are You Reading. Our guest this week is Ryan Sands, who can be found over at the Same Hat blog, recommending and even translating (Tokyo Zombie) some great, and occasionally bizarre manga (and I mean that in a good way).
To see what Ryan and the rest of us are reading this week, click on the link below. Then let us know what books you're enjoying and want to recommend (or not) in the comments section.
Comics A.M. | The comics Internet in two minutes
Publishing | Tezuka Productions and D-Arc Inc. has launched Weekly Astro Boy Magazine, a service that delivers manga by Osamu Tezuka to iPhones and iPods in the United States. Announced last month, it's the first English-language manga service for mobile devices.
If I'm reading the site correctly, the premier "edition" of Weekly Astro Boy Magazine offers the first volume of Astro Boy for free. Subsequent volumes of that title, and other Tezuka classics like Phoenix, Dororo, Black Jack and Buddha, cost 99 cents each, and are available in weekly installments. [Weekly Astro Boy Magazine]
Education | Ryan Sohmer and Lar deSouza, creators of the webcomic Least I Could Do, have established The Rayne Summers Webcomic Scholarship at The Center for Cartoon Studies in Vermont. Named for the protagonist of their nearly seven-year-old comic, the scholarship will cover tuition for one student each year who is working toward a career in webcomics. [Least I Could Do, via The Daily Cartoonist]
Comics College: Osamu Tezuka
Welcome to Comics College, a semi-monthly feature where we provide an introductory guide to some of the comics medium's most important auteurs and offer our best educated suggestions on how to become familiar with their body of work.
Today we're looking at one of the most influential and prolific and cartoonists in the world, a man who's body of work reportedly encompassed more then 150,000 drawn pages in just about every genre known to man. And that doesn't even begin to mention his pioneering work in animation. I'm speaking, of course, about Osamu Tezuka.
Comics A.M. | The comics Internet in two minutes
Libraries | There is, of course, follow-up on the decision by the Sioux Falls, South Dakota, to remove the anthology Stuck in the Middle: Seventeen Comics from an Unpleasant Age from middle-school libraries. Local CBS affiliate KELO reports on the reactions of parents and highlights some of the better-known challenged and banned books.
As we noted yesterday, teachers will still have access to the 2007 collection of stories about life as a teen-ager (by such contributors as Gabrielle Bell, Daniel Clowes, Joe Matt and Dash Shaw). That's because, in the words of School Board President Kent Alberty, "There is value in the book. One of the subjects addressed is bullying, something the district is very interested in making sure is handled appropriately, and the book does address that." [KELOLAND.com]
Publishing | Japan's NHK television network reports that publishing giant Shueisha, a co-owner of Viz Media, plans to develop plans to sell manga via mobile phones in the United States beginning in spring 2010. [Anime News Network]
Everyone's A Critic: A round-up of comic book reviews and thinkpieces
• Tom Spurgeon once again beats everyone to the punch with a review of Joe Sacco's new book, Footnotes in Gaza: The first good news to report … is that the cartoonist is in top form throughout." He also has good things to say about Prison Pit.
• Christopher Allen offers 60 ways of looking at Watchmen.
• Critics critique critics — Robert Boyd reviews Bart Beaty's Unpopular Culture: "This is a thought-provoking book, and I recommend it to anyone who is interested in comics-as-art."
• David Welsh gets schooled in college manga.
• Rob Clough calls MK Reed's new book, Cross Country "the most complex, ambitious and visually interesting of her comics."
• Perhaps if I link to Sean Collins' review of Refresh, Refresh, he'll forgive me for accidentally (I swear) stealing the title of his review feature.
• Nina Stone enjoyed the first issue of Cinderella: From Fabletown With Love: "All the pieces of the story just started to fit together perfectly."
• Grant Goggans declares The Art of Osamu Tezuka "very highly recommended."
• Finally, Kristy Valenti looks at a 1999 graphic novel drawn by Mia Wolff and written by acclaimed sci-fi author Samuel Delany.
Comics A.M. | The comics Internet in two minutes
Legal | A new study claim the shutdown two months ago of file-trading site The Pirate Bay by Swedish authorities "significantly, if temporarily, disrupted" the illegal trafficking of digital files worldwide. The emphasis is on temporarily. The white paper, released by anti-piracy company DtecNet, found the closing forced traffic to flood other BitTorrent trackers, "causing temporary secondary outages" for several days.
The study finds that BitTorrent traffic is soon expected to return to levels seen before the shutdown, with relatively new website OpenBitTorrent emerging as the successor to The Pirate Bay. [The Live Feed]
Sales charts | R. Crumb's much-publicized adaptation of The Book of Genesis debuts at No. 8 on USA Today's bestseller list. Meanwhile, the 46th volume of Masashi Kishimoto's popular shonen series Naruto inches up three spaces to No. 136. [USA Today]
Comics A.M. | The comics Internet in two minutes
Libraries | Two library employees in Nicholasville, Kentucky, were fired last month after they refused to allow an 11-year-old girl to check out The League of Extraordinary Gentlemen, which they dubbed pornographic. However, the policy of the Jessamine County Library states it's the responsibility of parents to decide what's appropriate for their child to read.
The fired employees, Beth Bovaire and Sharon Cook, stand behind their decision, asserting that the award-winning comic by Alan Moore and Kevin O'Neill contains lewd pictures that are inappropriate for children.
"If you give children pornography, a child, a 12 year old, can not understand and process the same way a 30 year old can," Cook told a local television news station. [WTVQ, WTVQ]
Libraries | A private university in Tokyo hopes to promote the serious study of manga by opening a library stocked with 2 million comics, anime drawings, video games and other artifacts. If everything goes as planned, the Tokyo International Manga Library would open on the campus of Meiji University in 2015. [AFP]
Publishing | Even after the closing last year of Virgin Comics, upbeat profiles of the Indian comics industry continue to appear regularly. But here Gaurav Jain, head of the Mumbai-based Illusion Interactive Animation, offers a more dismal assessment of the scene in India: "While competition has arrived, the local industry continues to live in its shell, churning out visually unappealing and terribly written local content with little or no film and television possibilities. One of the most widely read labels offers sanitized, vanilla retellings of Indian mythology and historical figures with visuals inspired from the works of Raja Ravi Verma. Derivative art work and bland writing, leads to visual fatigue." [The Wall Street Journal]
Crime, punishment and Tezuka
The Kurkutta blog posted a few sample pages from one of Osamu Tezuka's early works, namely his adaptation of Dostoevsky's Crime and Punishment. The scans are from a long-out-of-print English version that Frederick Schodt translated back when nobody knew what shojo meant. Look at the way he sets mood in these simple panels (remember: read right to left). Even in his early days, he was testing the boundaries of the medium. (found via Matthew Brady)
You, too, can design a Black Jack cover
Vertical Press book designer Peter Mendelsund wants some help choosing the color scheme for the next volume of Osamu Tezuka's Black Jack:
I am a simple man (I know) and choosing the colors for this design (of which I am proud) brings me great satisfaction every time. But… I thought it might be fun to open up this process to the readership in order to see if any of you have any radical ideas vis a vis color: what colors look good together, what colors pop, what colors ring your own peculiar bell etc. So dust off your color theory books or just fly by the seats of your collective pants. Anyone, as they say, can be a winner.
Go here and then here to read the rules and related information. Entries are due Sept. 9 and the winner gets a full set of the Black Jack series, which is a pretty awesome prize.
(Found via Drawn!)
Everyone's A Critic: A round-up of comic reviews and thinkpieces
• Man, everyone and their Uncle Bob is reviewing David Mazzucchelli's Asterios Polyp these days aren't they? This week alone we've seen Brian Hibbs, Rob Clough, Douglas Wolk and the LA Times' David Ulin.
Not wanting to be left out of the fun, I'll probably have my own review of the book up this Friday.
• The Groovy Age of Horror's Curt Purcell has been spending a lot of time talking about Blackest Night, and, given that he's not a regular fan, he has some interesting things to say about the crossover event. Rather than link to all the separate posts, I'll just say start here and work your way back.
Oh, and while you're at it, read his new review of Gilbert Hernandez's Speak of the Devil.
• Johnny Bacardi likes Blackest Night quite a bit too.
• Speaking of the Hernandez brothers, are you confused about where to dive into their expansive magnum opus, Love and Rockets? The Onion's AV Club is here to help. Continue Reading »
Dear Chris, please pick me up an Astro Boy cookie jar. Thanks.
Chris Butcher is once again touring the Land of the Rising Sun and sending back photos of his excursions. So far he's bought manga about cats and stopped by the Village Vanguard book store, but the real gold mine so far is his trip to the Tezuka World Installation. Man, I can think of at least five people who would love getting one of those Astro Boy coffee mugs for Christmas.


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Vani Jairamplay artist mix
Vani Jayaram (born November 30, 1945 in Tamil Nadu) is a prominent Indian singer. She is best known as a playback singer in Indian cinema, primarily in South Indian languages, although she has a wider repertoire. Vani's career started in 1971 and has spanned over four decades. She has done playback singing for over a thousand movies. In addition, she has recorded several private albums and participated in numerous solo concerts in India and abroad.


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Join us at Bloodyelbow.com for "King of the Cage: No Mercy" - Friday, Sep. 17th at 9:00 PM EST on HDNet:
Main Card:
Ray Mercer (1-0) vs Ron Sparks (5-0)
[135 Title] Jimmie Rivera def. Abel Cullum Split Decision
Myles Jury def. Sam Oropeza Submission (Rear Naked choke) 2:55 Round 1
[145 Title] Donald Sanchez def. Pat McGreal Submission (Rear naked choke) 2:27 Round 1
Jesus Martinez def. Chip Moraza-Pollard Decision
Guy Mezger tweeted about the Ray Mercer situation earlier:
Ray Mercer is now out of the upcoming KOTC. He was disallowed because a 13 yr old injury. Even though he has had fights since that injury.
Photoshop via MMA Mania


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PERK Physical Evidence Recovery Kit
What is it?
- This exam is designed to assist the examining physician or nurse in the collection of evidence for analysis by the Virginia Division of Forensic Science. If the assault took place within 72 hours of the time of the medical exam, this kit can be used.
- Physical evidence to check for semen from oral and/or anal penetration can be collected only within 24 hours of the assault. If the sexual assault occurred more than the 24 to 72 hours prior to the medical exam, evidence still may be collected without using the kit.
- A PERK exam can be performed after a sexual assault. The evidence collected can be held until a decision is made about pursuing legal action. It is recommended that if you pursue this option you consult with a University Counselor or Project Horizon about how to obtain this exam.
- Before the medical exam, the nurse or health care provider will ask for details about the assault. Even though these questions will be very difficult to answer, the information given may be helpful in identifying the assailant, in providing the survivor with optimum care, and in documenting the assault.
- Information is needed regarding the type of assault or penetration, such as oral, vaginal, or anal. The student will be asked where the assault occurred, such as in a car, on grass or carpet, etc.
- The medical staff will need information about the survivor's medical history regarding past and present health conditions, including the date of her last period, contraceptive history, and the date of their most recent voluntary sexual contact.
- Survivors have the right to refuse the PERK exam.
- All procedures should be explained to the survivor so that they understand why they are being done. If not, it's OK for them to ask the nurse or doctor to explain what they are doing. This may help the survivor maintain some feeling of control during the medical procedures.
- Sometimes it may be difficult to talk to Emergency Room staff. A member of University Counseling will accompany the student if they desire. Contact Student Health (540-458-8401) after hours. Or if a student prefers, a Project Horizon staff member can be called at 463-2594.
Information adopted from VAASA manual, 1989 and PCAR brochure entitled, "Rape: Seeking Medical Care," VCU's Sexual Assault Survivor's Handbook.


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