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Route Guide - iPhone / Android - Partners - Forum - Photos - Deals - What's New - School of Rock
Routes Sorted
L to R R to L Alpha
Secluded and north facing with an absolutely stunning approach hike, this place is about the closest thing to paradise. Noise from the trucks on I-80 and the limestone mill across the canyon does creep up, however, so there are quieter areas. Climbers accessing these routes must respect the owners property and keep a very low profile while visitng here.
Getting There
Once the car is parked as for the climbs in Pharoah's Glen, the view to the south will reveal a sweeping eastern shoulder to the tower called Pharoah's Hat. Once on the landscaped rock stairway, look for a faint trail that veers off to the east (left) marked by red dots spray painted on the rock. These trail markings were painted by the landowner. Follow the dotted trail to the hinterland of Pharaoh's Glen toward the Hat.
Climbing Season
3 Total Routes
The Classics
Browse More Classics in Pharaoh's Hat
Mountain Project's determination of some of the classic, most popular, highest rated routes for Pharaoh's Hat:
Cat In The Hat 5.7 5a 15 V+ 13 MVS 4b Trad, 2 pitches, 280'
Featured Route For Pharaoh's Hat
Cat In The Hat 5.7 5a 15 V+ 13 MVS 4b UT : Wasatch Range : ... : Pharaoh's Hat
Pitch #1: From the corner ledge, climb directly up the edge(arete). Initially, some dirty (but easy) grass hummock 3rd class scrambling leads to a bolt and steepening terrain. Follow the arete past a few more bolts to a two-bolt belay. 5.7, 55m.Pitch #2: Hop along the crest to the spectacular summit ridge of the tower passing two bolts to the final two-bolt belay. Improbable position and beautiful views. Sign in the tower top register and spray away. 5.5, 30m....[more] Browse More Classics in UT
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A top campaign aide to Rep. Nan Hayworth (R-NY) has resigned his post after writing on Facebook that supporters should "hurl some acid" at female Democratic officials.
"Jay Townsend has offered, and I have accepted, his resignation from his position with my campaign," Rep. Hayworth said Monday in prepared text. "Now let's return to talking about issues that really matter to families: job creation, spending restraint and economic development."
On a Facebook discussion board maintained by local Democratic activists, Townsend mockingly suggested throwing acid on female Senators who supported the Lilly Ledbetter Fair Pay Act but paid their male staffers more than their female staffers.
"Listen to Tom," he wrote in response to a Facebook user who criticized Republicans. "What a little bee he has in his bonnet. Buzz Buzz. My question today…when is Tommy boy going to weigh in on all the Lilly Ledbetter hypocrites who claim to be fighting the War on Women? Let's hurl some acid at those female democratic Senators who won't abide the mandates they want to impose on the private sector."
Acid attacks have notoriously been used against women who violate social traditions in Syria, Afghanistan and other countries.
"I posted a stupid, thoughtless and insensitive comment on a Facebook page," Townsend later wrote on his Facebook page. "It was stupid because my words were easily misconstrued; thoughtless because my choice of words obscured a point I was trying to make, and insensitive because some have interpreted the comment as advocating a violent act."
Photo: Shutterstock.com, all rights reserved.
(H/T: The Hill)
By Katie Halper
By TBogg
By Roy Greenslade, The Guardian
By The Conversation
Raw Story is a progressive news site that focuses on stories often ignored in the mainstream media. While giving coverage to the big stories of the day, we also bring our readers' attention to policy, politics, legal and human rights stories that get ignored in an infotainment culture driven solely by pageviews.
Founded in 2004, Raw Story reaches 9 million unique readers per month and serves more than 30 million pageviews.
Copyright © 2004-2013 Raw Story Media, Inc. All rights reserved.

subset: commoncrawl


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The Eisenhower Papers
The panelists discussed Keeping the Peace, the final volume of the President Dwight D. Eisenhower papers which covers his second term as… read more
The panelists discussed Keeping the Peace, the final volume of the President Dwight D. Eisenhower papers which covers his second term as president. The volume is published by Johns Hopkins University. After their presentations the panelists answered questions from members of the audience.
General Goodpaster was a staff secretary to President Dwight Eisenhower and later became NATO's supreme Allied commander for Europe and commander in chief of the United States European Command. close
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- Billington, James H. Librarian of Congress United States
- Eisenhower, Susan President Eisenhower World Affairs Institute
- Goodpaster, Andrew J. Staff Secretary (Former) White House
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I've joined Sara over at Craft Snob for a fun Holiday Ornament Parade. She's showcasing all sorts of holiday ornaments from diy bloggers. I'm sharing a cute little Ribbon Wreath Ornament, inspired from the jingle bell ribbon rings I made last year. Head over to see all the fun!
Jingle Bell Ribbon Wreath Ornament
Previous post: Rudolph the Red Nose Reindeer Thumbprint Cards
Next post: GoGo Crazy for 12 Days of Holiday Giveaways


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By Delivrine Registre - bio | emailNovember 17, 2008
DOUGLAS, GA (WALB) - A violent weekend in Douglas when three people were robbed in three separate holdups.
The first happened Friday night. A man says he was held up at gunpoint on Church Street.
Saturday afternoon, four men burst into a unit at Century Apartments and robbed the people inside the apartment.
The third robbery happened Saturday night at the Georgian Woods apartments on McNeal Drive.Two men pulled a gun and stole two gold necklaces and some cash from a man.
So far, no one's been arrested.
P.O. Box 3130
Albany, GA 31706
(229) 446-1010
FCC Public File
(229) 446-4005
EEO Report
Closed Captioning


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BRENTWOOD — Two longtime employees of the Rockingham County Attorney's Office have resigned amid an investigation by the Attorney General's Office.
Deputy County Attorney Thomas Reid, second in command after suspended County Attorney James Reams, submitted his resignation yesterday afternoon, according to Associate Attorney General Anne Edwards.
In a brief statement, Edwards said Reid was exonerated of any criminal wrongdoing.
"Mr. Reid was not the target of a criminal investigation and our investigation has not revealed any evidence that he engaged in any criminal conduct," Edwards said. "Mr. Reid has cooperated during our investigation, and we anticipate he will continue to cooperate with our ongoing investigation."
Reid's departure from the office after 15 years comes only a day after Rockingham County commissioners accepted the resignation of victim witness advocate Tara Longo.
Longo also stepped down from her position after 15 years amid concerns about her credibility. Reid, Longo and Reams were placed on administrative leave by county commissioners in November, following allegations of "management and operational issues" within the office.
Attorney General Joseph Foster also revoked Reams' authority as a prosecutor. Allegations of sexual harassment by Reams against female employees and the improper diversion of money in the office later surfaced.
Reams claims he is innocent. He is fighting for reinstatement and trying to salvage his reputation as the county's top prosecutor.
A Merrimack County Superior Court judge was to hear Reams' reinstatement request Tuesday. But Edwards said yesterday the state and Reams' attorney, Michael Ramsdell, have asked the hearing to be rescheduled while the criminal investigation continues.
Edwards refrained from speaking further about Reid.
But Brian Quirk, Reid's attorney, issued a statement on behalf of his client.
"The manner in which the investigation has been handled has taken a significant toll on my family," Reid said. "I also recognize that a continued suspension with pay is unfair to the taxpayers of Rockingham County. Therefore, I have resigned effective today."


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Driving on Starch 232
from the oh-mr.-fusion-you're-so-efficient dept.
It's Roland the Plogger again, wrong as usual.
It's been possible to convert cellulose to ethanol using enzymes for a while now. The problem is that making the enzymes is still too expensive for this to be useful as a fuel process. This Wikipedia article [wikipedia.org] provides some background on that. It's a good idea. If the cost of making the enzymes can be brought down, there's plenty of agricultural waste (straw, bagasse, corn cobs, wood chips) available at low or even negative (it costs money to dispose of it) cost. Venture capital is going into developing cost-effective processes.
But it's not likely to be done in a car's fuel tank. Something more like a brewery scaled up to oil refinery size is more like it.
Why, in a big tank [google.com] of course. Doesn't your local grocery store have one of these in the cereal aisle?
Not that you'd have each customer filling their gas tank, from empty, every day. But sure, figure a thousand tanks per week - that's only 6 an hour for a 24-hr 'starch station', and you'd have to fill a 12' x 16' tank [watertanks.com] every week full of starch. Not to mention the hassle of loading your car's tank with a powder. Are they really suggesting you'd buy off-the-shelf from a grocery store? What are you going to do, spoon it in, one tablespoon at a time? 3328 tablespoons later.... [google.com]
That should curb obesity in this country. But then we have all this energy already stored as fat on our bodies. Well, we'll just have to design a car that runs on human fat. Just cut that love handle, toss it in a gas/fat tank and there you go, drive to the store and buy more Twinkies to put that lost chunk of fat back and keep going...
That coal/oil burning/swamping CO2 into the atmosphere in what? 2 centuries or so of accumulated solar energy which took maybe millions of years to build up is exactly what the dilemma of global warming causes (some still dispute that it is actually happening or discredit any argument towards it).
Now you want to put all kinds of dirty burning junk into your "converter" to accelerate over a ton of steel and plastic and move one human body over some distance?
Not sure either what those hydrogen-from-starch inventors are dreaming about. Besides developing a completely new fuel system, if they want to take the hydrogen with enzymes away from starch (carbohydrate, made of C6H12O6 chunks), what's going to happen with the carbon and oxygen? That's not clear at all from that article. Doesn't production of CO2 defeat the purpose of using hydrogen? Ideal would be to generate hydrogen from renewable resources and burn it to gain energy. Maybe its because the CO2 would come from a renewable resource - starch grown now with plants?
One other thing to consider is the viability of having this enzyme process run in the tank of a vehicle. Even the most robust kinds of these reactions require a relatively stable environment. It might be possible to do this in a reactor in one's garage, but not in a vehicle that gets parked in the hot sun or below zero winter temperatures vehicles encounter. Additionally, is this process throttleable? It doesn't seem so. In other works, when you dump your starch in the tank, it begins producing H2 and continues until all the consumables are gone. If you park your car for a few days, the H2 produced is going to have to be stored. That means tanks and pumps.
This might work as the basis of a hydrogen fuel system, where the H2 is the product being pumped into your car. It might have a definite advantage over other fuel technologies in that the production process, being relatively benign environmentally, will promote the establishment of local starch refineries. They would seem to make for much more suitable neighbors than petrochemical plants. This will, in turn undermine the monopoly that the major producers have on production and distribution of fuel and keep profit margins within reasonable range. We might even see a combination of retail H2 outlets and home production equipment. If the prices spike up, you can switch to your backup stash of potatoes. Try storing a supply of gasoline at home when it goes on sale at Costco and see what your local fire department has to say.
The degree of technical confidence is inversely proportional to the level of management.


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Crooks call it 'Flocking'.
Burglaries…organized by street gangs.
Gina Silva reports that they've hit thousands of homes…in this FOX 11 Investigates.
In Part 2 coming soon to myFOXla.com …how some flocking crews are expanding into violent street crimes.
WTTG FOX 5 & myfoxdc5151 Wisconsin Ave. NWWashington, DC 20016Main Number: (202) 244-5151Newsroom: (202) email@example.com


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Masterful drama explores slavery's effects on families in Gem of the Ocean at Cygnet Theatre Company
Through his series of 10 plays, each set in a different decade, playwright August Wilson took a long look at life for the African American. "The Pittsburgh Cycle" earned two Pulitzer Prizes for Drama. The Cygnet Theatre in Old Town is staging the first of the series, "Gem of the Ocean."
It takes place in 1904, shadowing the memory of slavery. Drifter Citizen Barlow arrives at the home of 87-year-old Aunt Esther in search of asylum and spiritual redemption. Esther is a powerful character who believes in holding on to where you came from, your roots and your ancestors. She guides Citizen on a soaring, lyrical journey of spiritual awakening to the City of Bones.
Cygnet Artistic Director Sean Murray, who co-directs the production with Victor Mack, said he finds staging Wilson's plays appealing due to the playwright's ability to capture the mood, thoughts and attitudes of different decades.
"They all contain characters who are fully realized," Murray said. "They don't tend to have heroes and villains; they tend to be about people who have different philosophies and points of view that come into conflict. It's interesting how different situations work out."
"As I'm watching this cast, I'm realizing there is something big and universal about the play," Murray said. "Until you're able to look inward and find your personal strength and live a life of integrity, you're not able to move forward with life. We die as we live, I think is a political message August wrote as he was dying with cancer. I read he denied himself pain medications so he could keep his mind lucid and finish the play."
Much has been written about Wilson's brilliant use of language in his plays. Murray said it's almost like music, it just flows.
"Our cast includes a mix of eight actors; some have performed in Wilson's plays, some who are locally based, and some who bring new ideas to the play. I think it's a good mix for some discoveries.
"This play is about a vast community of people who still have a direct connection to slavery. There's a lot of discussion about what is freedom, and the of promise freedom not living up to itself because roadblocks have been set up to keep people from being free, politically economically and socially.
We have to look at what that does to the soul of people with that legacy. I believe Wilson is trying to put tangible faces to people in this story, and explore what the insult of human dignity does to people. When people fall, they fall hard, and usually it comes from not knowing who they are or what they are supposed to be."
If you go
What: "Gem of the Ocean"
When: Matinees, evenings to Feb. 24
Where: Cygnet Theatre Company, Old Town Stage, 4040 Twiggs St., San Diego
Tickets: $29-$44
Box Office: (619) 337-1525
Website: cygnettheatre.com
Related posts:
- Even the fish is funny in 'Mistakes Were Made'
- Mae West unveiled in new comedy at The Cygnet Theatre in Old Town
- Cygnet Theatre's quirky Behanding in Spokane keeps audiences riveted
- REVIEW: Cygnet's 'Our Town' reminds audiences that life is short … and precious
- Cygnet Theatre takes on Thornton Wilder's iconic 'Our Town'
Short URL: http://www.lajollalight.com/?p=101053


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Bibles For The World (BFTW) proudly announces the India Children's Choir will be performing at Hope Lutheran Church at 7 p.m. on Wednesday, February 6.
The famous India Children's Choir is on a 10-month tour of the United States. The Choir performs in churches, chapel services for ministries, schools, retirement homes and civic events, to name just a few. They come from the hills of Manipur on the India-Burma-China border and tell the story of their people's transformation from fierce headhunters, only two generations ago, to ambassadors for Christ. A Gospel of John was given to the tribal leaders in the early 1900's which set things into motion. Since that time, Dr. Rochunga Pudaite translated the Bible into the Hmar language for his people, and today 98% of the tribe claim Jesus Christ as their Lord. The 22 children, ranging in age from 8 to 12 years old, are direct descendants of these former headhunters who live in the remote areas in Northeast India.
Dr. Rochunga Pudaite, along with his wife, Mawii, founded Bibles For The World in 1972, a mission dedicated to sharing the Bible with people in their native languages on a global scale. Since its inception BFTW has sent over 16 million New Testaments to more than 100 countries around the world. The India Children's Choir is a ministry of Bibles For The World.
Bibles For The World also currently runs 30 village schools, five high schools, a junior college, a seminary and 8 schools for the untouchable, outcaste Dalits near Delhi. The total enrollment of the schools is around 7,000 students; about 15 percent of whom are sponsored by individuals in America. In addition, a hospital has been established by Bibles For The World in Northeast India ministering to the people's physical and spiritual needs.
Hope Lutheran Church is located at 5700 98th Street, at Frankford Avenue.
For more information, call (806) 798.2747, or (click here).
|Community Events Calendar
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Who should get tested for vitamin B12 (cobalamin) deficiency and which is the best test to use: serum B12, methylmalonic acid (MMA), or holotranscobalamin levels?
Image thanks to Bobjgalindo via Wikimedia Commons.
Should people who eat plant-based diets be tested for vitamin B12 deficiency? In my opinion, medical tests should only be ordered if the results, one way or the other, are going to change what you do. If your test came backing showing your B12 levels were low, what would you do? You'd insure a regular, reliable source of vitamin B12. If your tests came back showing your levels were OK, what would you do? You'd ensure a regular, reliable source of B12 because you wouldn't want them to become not-OK.
So, if it's not going to matter either way, I wouldn't worry about it: with two exceptions. I recommend anyone with unexplained neurological, psychiatric, or developmental symptoms be tested, especially in infants, toddlers, vegans, and anyone over 50; and, out of an abundance of caution, I've always tested all my pregnant and breast-feeding vegan patients, just because the consequences of deficiency are so potentially devastating.
Better than getting a serum B12 level drawn, though, which most doctors do, a methylmalonic acid level is a superior test for B12 deficiency, which can be blood or urine. You can just pee in a cup for it.
Here's why measuring MMA levels is better. About 50 people started eating vegan. Within a few years half became B12-deficient. But look at their B12 levels. All these vegans had functional B12 deficiency despite normal levels of B12 in their blood, showing that MMA is a more effective test.
Now their has been a case report published of someone with apparent B12 deficiency who had normal B12 and MMA levels. So since we're always looking for a better test, it looks like HoloTC is it, measuring Holotranscobalamin levels, shown to be more sensitive and specific, meaning fewer false negatives and false positives. If your level is under 20 you start treatment. If it's over 30, you can be pretty sure you're OK. And if it's in the middle, you follow up with a second-line test.
If you are deficient, you can be treated with a ruby-red mad-scientist-looking injection of B12. The color is from the cobalt in the molecule. But one of medicine's best-kept secrets is the efficacious use of high-dose oral B12 -- safer, cheaper. 2000 microgram supplements every day for two weeks should do it, before having patients starting or resuming their regular, reliable regimen of B12.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. This is transcript contributed by Bruce A. Hamilton.
To help out on the site please email firstname.lastname@example.com
This concludes our five-part video series on B12 this week. Please leave any questions you may have below. If you're new to the issue, Vegan B12 Deficiency: Putting It into Perspective and Safest Source of B12 are good places to start. The consequences of B12 deficiency can be grave (see Inverted Rabbit Sign), but getting enough is easy: B12 can be taken weekly (see Cheapest Source of Vitamin B12) or daily (see Daily Source of Vitamin B12). See my full recommendations and check out the other 1000+ topics I cover here at NutritionFacts.org.
This concludes our five-part video series on B12 this week. Please leave any questions you may have below. If you're new to the issue, Vegan B12 Deficiency: Putting It into Perspective and Safest Source of B12 are good places to start. The consequences of B12 deficiency can be grave (see Inverted Rabbit Sign), but getting enough is easy: B12 can be taken weekly (see Cheapest Source of Vitamin B12) or daily (see Daily Source of Vitamin B12). See my full recommendations and check out the other 1000+ topics I cover here at NutritionFacts.org.
In my research B12 seems to be the most confusing and unadressed nutrient in the vegan community and is fraught with ignorance and misinformation.
This is how I see the B12 problem:
1) Ignore the topic as because they don't perceive it to be an issue or at least no issue since they have no symptoms.
Many vegans are people who spent years destroying their health – especially damaging their digestive track, decreasing intrinsic factor… and those and many other factors lower B12 creation and absorption and tend not to just magically get fixed immediately on a vegan diet.
2) Many vegans do not eat very health vegan foods.
3) RE: 1) do don't get tested or tested using methods that are well known to be fairly inaccurate (e.g. blood tests)
4) RE: 1.2.1) Try increasing with things that have either not been scientifically vetted yet to increase B12 and/or no proven scientific track record of increasing B12 levels.
5) RE: 1.2.2) Believe they just need to eat better and don't need to test or can skip the retesting.Comments, additions, corrections…?
There are indeed junk food vegans and healthy vegans. The issue of vitamin b12 though is fairly well addressed and this is an absolutely necessary nutrient to supplement when on a vegan diet unless one is consuming fortified foods.
check out this video on supplements worth taking.
Thanks for the reply!
Q: On a separate topic – What's with the "Toxins" name?
I just read on my bottle of B12 that it "Contains various fish species". What's a good all vegan source of getting B12?
Question for you: My husband, who has been vegan for 4 years, has numbness in the balls of his feet. He went to his doctor, who did a blood test which indicated his B12 levels were ok. From there he went to a neurologist, where no reason for the numbness could be found. He is suggesting that he take a high dose of B12 without bothering to get a test. Thoughts?
What was the type of test(s) given?
I assume the test was as serum B12 which is insufficiency sensitive. If he doesn't want to get a better test (like a urine MMA), I would recommend he take a B12 replenishment regimen of 2000 mcg every day for two weeks before going back to supplementing normally.
Thank you for addressing this important and neglected issue. Going back to supplementing normally is risky. If the person is malabsorbing severely, and that is possible, they should stay on at least 1000 mcg dose. Your video is great, until the end.
Hi Dr. Greger,
I've viewed the videos on vitamin B-12 and have a question regarding supplementing just this one B vitamin. I read somewhere a long time ago that taking single B vitamins alone can cause imbalances in the other B vitamins. Is there anything to this?
Thanks for Nutrition.org which is a great resource.
No worries–there is no problem taking vitamin B12 in isolation.
Raw Food World has B-12 patches available. But it's confusing because the B-12 researcher who spoke about B-12 states that the cobalamin is not the human active form and that we need to consume the methylcobalamin form. He says the MMA score should be between .58 and 3.56. The Homocystine test should score between 2.2 and 13.2. It's confusing because you are recommending oral cobalamin.
So, after watching a couple videos about the importance of B12, I decided to break down and buy a bottle of B12 supplements at the health foods store. But I noticed while I was there that there are also "B-Complex" supplements which contain other B-vitamins such as B1, B2, and B6. Should vegans supplement their diet with these vitamins as well or just with B12? Are all the other B's not as important or are they like the multivitamin – leading to higher mortality rates in excess? It seems that they are not talked about as much as B12. Why is that?
A b complex vitamin is unnecessary. We can acquire more than enough of all the b vitamins through food except vitamin b12. Vitamin b12 is the only byproduct of bacteria. If you search http://nutritiondata.self.com/ for any plant food you can see a full vitamin and mineral profile. You will find that all plant foods not only contain all b vitamins, but they also are all complete proteins and all contain sufficient levels of omega 3.
I'd like to know too! I have been taking the Methylcobalamin because I read years ago that IT was the correct one to take. :?
Dr. Greger, am I in the danger zone?! I've been taking the Methylcobalamin for years now. Should I switch to the cobalamin??
If you are taking methylcobalamin, you are taking the more natural and useful form of cobalamin.
That's what I have thought because I read it years ago; however, I infer from what Dr. Greger has stated that the cyanocobalamin is the one we should be taking.
Here (in the comments),
he seems to saying the Methyl- isn't the best choice. The high amount suggested looks like a typo…I have asked for clarification; I hope Dr. Greger can clear it up for us (me!)
Hi everybody. I see quite a few of you have asked about which B-12 supplement is best. When I took the Plant Based Nutrition Certificate program by T. Colin Campbell via eCornell University, we had a lecture on this exact topic. The lecturer was Dr. Matt Lederman, below is what he advised based on my notes from the class:
There are B-12 analogs – substances which are very similar to B-12. However, analogs are not biologically active in the human body, meaning they do not perform the functions that B-12 does. Examples of a supposed B-12 analogs would be Spirulina & some algae.
Dr. Lederman advises the use of methylcobalamin, which is a natural derivitive used by the body and he advises against the use of cyancobalamin, which is a synthetic version of B-12. And that when broken down by the body to methylcobalamin and adenosylcobalamin, the process leaves a minimal amount of cyanide behind.
Dr. Greger, there is a video in which you talk about vegan longevity vs. meat-eaters longevity. You mentioned that a study discovered that meat-eaters live as long or longer than vegans and vegans are more propense to heart attacks and neural damage due to the low levels of B12. Can you point me in the direction of the conclusion of that video? Is there a happy conclusion for vegans? How old are those findings? Thank you
Dr Greger, three of my local collection sites have not been able to locate a lab that performs the holotranscobalamin levels test. Please supply contact information for labs that can perform this test. TNX
Thank you for the explanative video.
I was diagnosed 17 years ago after the birth of my first child with a vitamin B deficiency after experiencing depression, brain fog and a series of other symptoms commonly experienced by breast feading mothers. After further testing the naturopath who was treating me at the time established that I was not able to assimilate the B's orally due to IBS and made me undergo a regimen of B injections which seem to clear the matter, along with supplement of stevia for a lazy thyroid if I remember well.
Over the years my digestive issues have gone from bad to worth and looking back at it I have most certainly experienced episodes of mild depression and the likes, though never fully paid attention to it.
In the last 5 years I started to experience serious insomnia issues often associated with extreme bloating which led to difficult breathing only bearable in standing position. Then a little less than 2 years ago I fell pregnant with my third child, now just over a year old and whom I am still breast feading, and to the bloating was added an extreme case of restless leg syndrome, constant day and night throughout my pregnancy which in turn transformed the episodes of insomnia to a constant state as well. Aside of that the pregnancy was great and easy but I reached delivery utterly exhausted and i am presently barely recovering from the lack of sleep.
Shortly after delivery I experienced a sharp pain in the right side of my body, my right leg having been the one most affected by the restless syndrom as well. This vanished somewhat within a few hours, though an ongoing twitchy feeling settled down after that with a constant sensation of electric current running through my nerves from my little toe, with strong sensation in the sole of my foot and incessant debilitating itching up the outer side of my legs seemingly ending in the area of my reproductive organs. I thought at first that it must be related to the slight urethrocele that seemed to occur after the delivery, but that issue seem to resolve after a couple of months and the itch remained.
Then all at once it seems the IRS came back in force, I started to experience irritating burning sensation in my bladder and a couple of excruciating pain in my chest and back below my rib cage. Concerns for gall stones, yeast infection were raised but quickly turned down after appropriate screening test were done and came back clear.
Other symptoms experienced which seemed unrelated to the ones above and rather common to the aftermath of pregnancy were fatigue, brain fog though rather extreme with incapicity to focus on anything, sensitivity to light and a strange sensation of seeing fleeting shadows pass by….
That is when my gyn mentioned that i probably was experiencing a lack of vit B, which seemed to have become quite severe. She then sent me to an internist who put me on a regimen of vit B 12 complex, first orally with dosage of 15 000 mg a day for a week with no results and then shots of 5000 mg twice a week. The latter seemed to have quite positive effect and within 2 months the brain fog, sensitivity to light, fleeting shadows and inability to focus seemed to have disappeared. The nervous itch sensation though lesser at first is now slowly creeping back in :-(, along with the burning sensation and last but not least my buttocks are covered with bruises from the injection spots.
The midwife who administrates them suggested that I get tested for the B levels to see if what they are presently at….though as I had not previously done a serum or any of the other test you mention in the video, I feel that the answer will require more than a mere testing for vit B.
With much hope the above is clear and you'll be able to provide with some light and advises.
Many thanks,
P.S.:In addition, as this will probably come to be relevant at some point, I have had to change my diet quite early on since breast feeding my little one, as I noticed that like his older brothers he seemed to develop a crying habit and some rashes around a month old. After on going an elimination diet and reintroducing the avoided food one by one, I was able to assess that wheat product would make him cry for long periods, dairy resulted in specks of blood in his stools, eggs gave him peeling off rashes and meat/fish resulted in diarrheas. So all the above were eliminated from my diet for good and he has been an easy hardly ever crying baby ever since.
Try searching home blood tests for the accurate, active B12 test. Make sure injections are methylcobalamin rather than cyanocobalamin and preferably preservative free or with minimal preservatives. Dr.Greger, please could I find out whether supplements would affect the U/MMA test or homocysteine test? My body is not retaining the supplements so I'm going to buy the injections from Trim Nutrition. I would also like a test for my records. Many, many thanks.
Dr Greger, I wanted to know – is there any evidence that if a person takes a B12 supplement daily (when B12 is normal) that a person's body could eventually not produce it's own and become dependent on the supplement? I have heard this but have not seen any evidence of it. I would like to know if you have. Thank you so much for your work.
DrBarbaraHoldeman: Dr. Greger has a great set of videos on B12. I highly recommend watching them. This is just one of the videos.
What other NutritionFacts videos tell us is that B12 is made by bacteria in our lower gut. The B12 is so far down in our lower gut, our bodies do not absorb it properly. What is one way that we know this? People who are deficient in B12 and then eat their own poop pills (I kid you not), see their B12 levels rise.
In other words, it's never about how much B12 our bodies make. The issue is how we get B12 to go into our bodies. We could get it naturally say by drinking dirty water and eating non-washed fruits and veggies the way our ancestors did (or eating feces encrusted chicken the way our friends do today), OR we could take a cheap, safe supplement one a week.
That's a summary of the videos. Dr. Greger does a better job of explaining it. Hope that helps answer your question though.
You bring up a question that I believe needs to be properly addressed based on so much misinformation on this B12 topic and especially the persistent claim that – internal B12 production will be reduced from B12 supplementation!
I understand that your question was directed to Dr Greger. I am not speaking for him, yet I thought I might provide an informative response to your question.
My experience so far is that every person who has made such a claim has been unable (and even unwilling – mostly what seems to be delusional arrogance) to back up (they are the ones tasled with the burden-of-proof) their claim with any form of empirical medical science data. I have yet to have someone make such a claim that has had any long term formal education in nutrition/biology. Mostly the people who make such a claim (reduction of B12 from supplementation) seem to be enthusiastic diet advisers (guru's) or from their unquestioning followers who are simply repeating their guru's B12 statements.
Maintaining my critical thinking and skepticism (belief and/or acceptance AFTER sufficient facts) their claim remains as a wishful hypothesis (if that) and does not yet (if ever) qualify as a medical science theory.
My understanding of B12 in regards to the claim that, internal B12 production will be reduced from B12 supplementation (Note: the first three are my premises and #4 is my conclusion):
1.) B12 can be made by several types of bacteria.
2.) In order for B12 to be controlled (reduced or increased) by the human body it would require that our body control the amount and type of bacteria that produces B12.
3.) The B12 produced in the human body is to far down the intestinal track to be absorbed sufficiently enough to raise B12 levels.
4.) Therefore, even if our body was able to control B12 bacteria quantity and production it would not be enough to overcome the limitations of #3
I am open to my premises and conclusion (already verifiable by medical science studies) being proven incorrect and await (without holding my breath) for their different and/or opposing evidence that is verifiable through medical science that will have the possibility of validating their claim.
"The great enemy of the truth is very often not the lie, deliberate,
contrived and dishonest, but the myth, persistent, persuasive and unrealistic." John F. Kennedy
Hi dr Greger, fantastic site
i am on raw food, vegan, and was hoping to find some info —friends and i wonder if we can get B12 f.i. from germinated and then fermented chickpeas
they get a ´´french cheesy´´ smell, mixed in salads quite good, if you like frech cheese that is…
i seem to have heard (foodnsports.com) that slightly ´´off´´ vegetables have b12 in them
or is that myth??
thank you
Doctor, I am confused. Didn't you say in a previous video that we can only take 250mg of b12 a day? Is taking above that only in case of cobalt deficiency?
Ted: Dr. Greger's Optimum Nutrition Recommendation page includes the following for B12:
>> At least 2,500 mcg (µg) cyanocobalamin once each week, ideally as a chewable, sublingual, or liquid supplement *OR*
>> at least 250 mcg daily of supplemental cyanocobalamin (you needn't worry about taking too much) *OR*
>> servings of B12-fortified foods three times a day, each containing at least 25% U.S. "Daily Value" on its label
>>Those over 65 years of age should take at least 1,000 mcg (µg) cyanocobalamin every day.
from: http://nutritionfacts.org/2011/09/12/dr-gregers-2011-optimum-nutrition-recommendations/
My understanding is: The reason for the non-linear amounts is because of how the body absorbs and holds B12. Now you can put this into perspective with the video information. Here is the last paragraph of the transcript:
"If you are deficient, … one of medicine's best-kept secrets is the efficacious use of high-dose oral B12 — safer, cheaper. 2000 microgram supplements every day for two weeks should do it, before having patients starting or resuming their regular, reliable regimen of B12."
I believe he is talking about deficiency in B12, not cobalt.


text:
Research Topics
orphan drug production
Summary: Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications172 found, 100 shown here
- Endovasc establishes orphan drug testIrene M Walczak
Diabetes Technol Ther 4:740-1. 2002
- Unresolved issues in contraceptive health policyNatalie D Reaves
Economics Department, Rowan University, Glassboro, New Jersey 08028, USA
Health Care Women Int 23:854-60. 2002..S. federal legislation known as the Food and Drug Administration (FDA) defense could provide the economic incentives needed to spark the second contraceptive revolution...
- Orphan drugs and orphan tests in the USAJess G Thoene
Hayward Genetics Center, Tulane University School of Medicine, New Orleans, LA 70112, USA
Community Genet 7:169-72. 2004
- The US Orphan Drug Act: rare disease research stimulator or commercial opportunity?Olivier Wellman-Labadie
Division of Dermatology, Department of Medicine, University of British Columbia, 835 West 10th Ave, Vancouver, BC, Canada
Health Policy 95:216-28. 2010..This study investigates issues associated with the United States Orphan Drug Act...
- Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000-2009K I Kaitin
Tufts Center for the Study of Drug Development, Tufts University, Boston, Massachusetts, USA
Clin Pharmacol Ther 89:183-8. 2011..1 and 6.9 years, respectively). The results provide the underpinnings of a fundamental shift in the structure of the research-based industry...
- Why rare diseases are an important medical and social issueArrigo Schieppati
Clinical Research Centre for Rare Disease Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Lancet 371:2039-41. 2008
- Estimating the budget impact of orphan medicines in Europe: 2010 - 2020Carina Schey
GMAS, Chiswick Business Park, London, W4 5YA, UK
Orphanet J Rare Dis 6:62. 2011..The aim of this study was to predict the total cost of orphan medicines in Europe between 2010 and 2020 as a percentage of total European pharmaceutical expenditure...
- Clinical research for rare disease: opportunities, challenges, and solutionsRobert C Griggs
Department of Neurology, University of Rochester, 1351 Mt Hope Avenue, Suite 203, Rochester, NY 14620, USA
Mol Genet Metab 96:20-6. 2009....
- Assessing the economic challenges posed by orphan drugsMichael F Drummond
Centre for Health Economics, University of York, Heslington, York, UK
Int J Technol Assess Health Care 23:36-42. 2007....
- Drugs for exceptionally rare diseases: do they deserve special status for funding?D A Hughes
Centre for Economics and Policy in Health, Institute of Medical and Social Care Research, University of Wales, Bangor, UK
QJM 98:829-36. 2005..Mechanisms are discussed for creating a policy that would reduce geographical inequalities in provision across Europe...
- Budget impact analysis of orphan drugs in Belgium: estimates from 2008 to 2013Alain Denis
Yellow Window Management Consultants, Antwerp, Belgium
J Med Econ 13:295-301. 2010..This article aims to calculate the impact of orphan drugs on the Belgian drug budget in 2008 and to forecast its impact over the following 5 years...
- Patent sensePaul Herrling
Corporate Research, Novartis International, Basel, Switzerland
Nature 449:174-5. 2007
- Predictors of orphan drug approval in the European UnionHarald E Heemstra
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P O Box 80 082, 3508 TB, Utrecht, The Netherlands
Eur J Clin Pharmacol 64:545-52. 2008..Recent literature discusses factors that may influence the development of new orphan medicinal products in the EU. This study aims to identify predictors for successful marketing authorisation of potential orphan drugs in the EU...
- Market incentives and pharmaceutical innovationWesley Yin
University of Chicago, 1155 E 60th Street, Chicago, IL 60637, United States
J Health Econ 27:1060-77. 2008..Tax credits can stimulate R & D; yet because they leave revenue margins unaffected, tax credits appear to have a more limited impact on private innovation in markets with smaller revenue potential...
- Is the current approach to reviewing new drugs condemning the victims of rare diseases to death? A call for a national orphan drug review policyJoe T R Clarke
Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ont
- Mission possibleAndrew L Hopkins
Pfizer Global Research and Development, Sandwich, UK
Nature 449:166-9. 2007
- Rare essentials: drugs for rare diseases as essential medicinesPieter Stolk
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands
Bull World Health Organ 84:745-51. 2006..In this paper we propose selection criteria for an Orphan Medicines Model List that could form a departure point for future work towards an extensive WHO Orphan Medicines Programme...
- Expanding global research and development for neglected diseasesDavid J Winters
The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland
Bull World Health Organ 84:414-6. 2006
- Choosing the right incentive strategy for research and development in neglected diseasesStephen M Maurer
Goldman School of Public Health, University of California, Berkeley, CA 94720 7320, USA
Bull World Health Organ 84:376-81. 2006..The efficiency of pay-as-you-go methods depends on sponsors' willingness to withdraw funding from failed drug discovery programmes...
- Potential interactions of the Orphan Drug Act and pharmacogenomics: a flood of orphan drugs and abuses?David Loughnot
Am J Law Med 31:365-80. 2005
- Exploring emerging technologies using metaphors--a study of orphan drugs and pharmacogenomicsWouter Boon
Department of Innovation Studies, Copernicus Institute for Sustainable Development and Innovation, Utrecht University, Heidelberglaan 2, 3584 CS Utrecht, The Netherlands
Soc Sci Med 66:1915-27. 2008....
- Developing drugs for developing countriesDavid B Ridley
Fuqua School of Business, Duke University, Durham, North Carolina, USA
Health Aff (Millwood) 25:313-24. 2006..In a well-functioning market, the voucher would speed access to highly valued treatments. Thus, the voucher could benefit consumers in both developing and developed countries at relatively low cost to the taxpayer...
- Does orphan drug legislation really answer the needs of patients?Marlene E Haffner
Office of Orphan Products Development, Food and Drug Administration, Amgen, Washington, DC, USA
Lancet 371:2041-4. 2008
- Emergence of orphan drugs in the United States: a quantitative assessment of the first 25 yearsM Miles Braun
Office of Orphan Products Development, US Food and Drug Administration, Silverspring, Maryland 20993, USA
Nat Rev Drug Discov 9:519-22. 2010..The implications of such findings for future development and marketing of therapies for rare diseases are discussed...
- A comparative study of European rare disease and orphan drug marketsAlain Denis
Yellow Window Management Consultants, Antwerp, Belgium
Health Policy 97:173-9. 2010..This article aims to compare regulatory aspects of rare disease and orphan drug markets in Belgium, France, Italy, the Netherlands, Sweden and the United Kingdom...
- Societal views on orphan drugs: cross sectional survey of Norwegians aged 40 to 67Arna S Desser
Department of Health Management and Health Economics, University of Oslo, PO Box 1089, Blindern, N 0317 Oslo, Norway
BMJ 341:c4715. 2010..To determine whether a general societal preference for prioritising treatment of rare diseases over common ones exists and could provide a justification for accepting higher cost effectiveness thresholds for orphan drugs...
- Building local research and development capacity for the prevention and cure of neglected diseases: the case of IndiaH E Kettler
Office of Health Economics, London, England
Bull World Health Organ 79:742-7. 2001..Further studies are required on how Indian companies would respond to push and pull incentives originally designed to persuade multinational corporations to do more R&D on neglected diseases...
- Safety-related regulatory actions for orphan drugs in the US and EU: a cohort studyHarald E Heemstra
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
Drug Saf 33:127-37. 2010..Several studies have been conducted on safety-related regulatory actions for drugs, but none of these have specifically focused on orphan drugs...
- Translation of rare disease research into orphan drug development: disease mattersHarald E Heemstra
Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
Drug Discov Today 14:1166-73. 2009..Consequently, additional incentives should focus on stimulating the specific needs of rare disease research at disease class level...
- A new model to evaluate the long-term cost effectiveness of orphan and highly specialised drugs following listing on the Australian Pharmaceutical Benefits Scheme: the Bosentan Patient RegistryAj Owen
Centre for Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
J Med Econ 11:235-43. 2008..Risk-sharing schemes between drug sponsor and government may provide an acceptable method of balancing the uncertainty of longer-term cost effectiveness with the public demand for equitable and timely access to new drugs...
- The orphan drug backlashThomas Maeder
Sci Am 288:80-7. 2003
- Is orphan drug status beneficial to tropical disease control? Comparison of the American and future European orphan drug actsP Trouiller
Centre Hospitalier Universitaire de Grenoble, France
Trop Med Int Health 4:412-20. 1999....
- Orphan drug legislation: lessons for neglected tropical diseasesStefano Villa
Centre for Research on Health and Social Care Management CERGAS, Universita Bocconi, Milan, Italy
Int J Health Plann Manage 24:27-42. 2009..Second, small-sized companies, which have played a successful role in the development of orphan drugs for rare diseases, may also represent a good business strategy for the case of tropical diseases...
- Orphan drugs and the NHS: should we value rarity?Christopher McCabe
White Rose Initiative in Health Technology Assessment, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield S1 4DA
- Adopting an orphanAndrea Rinaldi
EMBO Rep 6:507-10. 2005
- Orphan drugs revisitedC McCabe
Health Economics and Decision Science, School of Health and Related Research, Regent Court, 30 Regent Street, Sheffield S1 4DA
QJM 99:341-5; discussion 350-1. 2006
- Are rare diseases still orphans or happily adopted? The challenges of developing and using orphan medicinal productsJames W Dear
Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
Br J Clin Pharmacol 62:264-71. 2006..In this article we review OMPs and the incentives for their development and discuss the challenges presented by funding these treatments...
- Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malariaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
PLoS Med 3:e102. 2006
- A journey of hope: lessons learned from studies on rare diseases and orphan drugsM Wästfelt
Strategy and Development Office, Karolinska Institutet, Stockholm, Sweden
J Intern Med 260:1-10. 2006..These lessons, along with the crucial importance of cooperation between academic institutions, pharmaceutical companies, patient advocacy groups and society in the elucidation of rare diseases, are highlighted in the present review...
- Assessing the economic challenges posed by orphan drugs: a comment on Drummond et alChristopher McCabe
Int J Technol Assess Health Care 23:397-401; author reply 401-4. 2007
- The US orphan drug programme 1983-1995S R Shulman
Tufts Center for the Study of Drug Development, Tufts University, Boston, Massachusetts, USA
Pharmacoeconomics 12:312-26. 1997....
- Adopting orphan drugs--two dozen years of treating rare diseasesMarlene E Haffner
Office of Orphan Products Development at the Food and Drug Administration, Rockville, MD, USA
N Engl J Med 354:445-7. 2006
- Rare diseases, orphan drugs and their regulation: questions and misconceptionsErik Tambuyzer
Genzyme, Ikaroslaan 53, B 1930, Zaventem, Belgium
Nat Rev Drug Discov 9:921-9. 2010..This article provides an industry perspective on some of the common questions and misconceptions related to orphan drug development and its regulation, with the aim of facilitating future progress in the field...
- Two decades of orphan product developmentMarlene E Haffner
Office of Orphan Products Development, US Food and Drug Administration, Room 15A08, 5600 Fishers Lane, Rockville, Maryland 20857, USA
Nat Rev Drug Discov 1:821-5. 2002....
- [Orphan drugs--medications for patients with rare diseases]Desirée Thielke
Laegehuset, NIVA, Amtssygehuset i Gentofte, Dermatologisk afdeling, og Swedish Orphan International AB
Ugeskr Laeger 168:2236-8. 2006..S. Congress passed the Orphan Drug Act, creating financial incentives for manufacturers. Since 2000 the EU has had a similar regulation, resulting in more than 20 ODs being granted marketing authorisation in the EU...
- [Hope for patients with rare diseases--"orphan" drugs]M Kuzelova
Katedra farmakologie a toxikologie FaF UK, Bratislava, SR
Cas Lek Cesk 145:296-300. 2006..The real availability of "Orphan" medicinal products in the particular EU member states is analysed...
- Improving access to medicines in poor countries: the role of universitiesDave A Chokshi
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS Med 3:e136. 2006
- The quantity and quality of worldwide new drug introductions, 1982-2003Henry G Grabowski
Department of Economics, Duke University, Durham, North Carolina, USA
Health Aff (Millwood) 25:452-60. 2006..S. firms overtook their European counterparts in innovative performance or the introduction of first-in-class, biotech, and orphan products. The United States also became the leading market for first launch...
- Promoting, improving and accelerating the drug development and approval processesA I Graul
Drug News Perspect 20:45-55. 2007..This article reviews the three programs and provides a capsule view of new developments in these vital areas during the year 2006...
- Vouchers for FDA priority reviewsIan D Spatz
Health Aff (Millwood) 25:1184; author reply 1184-5. 2006
- Orphan Drug Act passes quarter-century milestone in fight against rare diseasesGreg Lavine
Am J Health Syst Pharm 65:1205, 1210. 2008
- [European incentives for orphan medicinal products]H Enzmann
Bundesinstitut fur Arzneimittel und Medizinprodukte, Bonn, BRD
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51:500-8. 2008..This article describes the procedure of orphan drug designation and highlights problems regarding coverage of treatment costs and increasingly individualized medicine...
- FDA program could boost treatments for neglected diseasesKate Traynor
Am J Health Syst Pharm 65:1595-6. 2008
- Orphan economics: the downside of supplyside pharmacologyKurt Samson
Ann Neurol 64:A13-6. 2008
- Proposal ties financial incentives to development of drugs for neglected diseasesDonna Young
Am J Health Syst Pharm 63:694, 696. 2006
- Promoting, improving and accelerating the drug development and approval processesA I Graul
Drug News Perspect 21:36-43. 2008..This article reviews the three programs and provides a capsule view of new developments in these vital areas during the year 2007...
- Orphan drugsGary D Novack
Ocul Surf 6:52-3. 2008
- Should the patent system for new medicines be abolished?J A DiMasi
Tufts Center for the Study of Drug Development, Tufts University, Boston, Massachusetts, USA
Clin Pharmacol Ther 82:488-90. 2007
- Access to information supporting availability of medicines for patients suffering from rare diseases looking for possible treatments: the EuOrphan ServiceDonatas Stakisaitis
Mykolas Romeris University, Ateities 20, Vilnius, Lithuania
Medicina (Kaunas) 43:441-6. 2007..In this perspective, EuOrphan could become a very valuable tool for globalizing the information about the availability of treatment (authorized or under development) of orphan patients...
- Law and research could add up to profitable niche drugsBurkhard Haefner
Nature 446:856. 2007
- Neglected diseases: progress in drug developmentSimon L Croft
Curr Opin Investig Drugs 8:103-4. 2007
- Biologics for inflammatory bowel disease: drug approval and monitoring in the United StatesWilliam J Tremaine
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 1st Street, SW, Rochester, MN 55905, USA
Gastroenterol Clin North Am 35:735-41. 2006..FDA regulation of a new drug or biologic can be divided into three stages: the commercial IND, the NDA, and postmarketing (phase 4) studies. It is unclear if generic versions of biologics can be approved within the current legislation...
- Marlene HaffnerCatherine Goodman
Nat Chem Biol 2:657. 2006
- The Minor Use and Minor Species Animal Health Act: past, present, and futureCarol J Haley
Pfizer Inc, New York, NY, USA
Food Drug Law J 61:13-43. 2006
- Clinical trials of orphan medicinesBrendan M Buckley
European Centre for Clinical Trials in Rare Diseases, University College Cork, Cork, Ireland
Lancet 371:2051-5. 2008
- Economic and regulatory considerations in pharmacogenomics for drug licensing and healthcareJai Shah
Department of Social Policy, London School of Economics and Political Science, and is now at the Canadian Institutes of Health Research, 410 Laurier Avenue West 11th Floor, Ottawa, Ontario K1A 0W9, Canada
Nat Biotechnol 21:747-53. 2003
- U.S. Food and Drug Administration drug approval summaries: imatinib mesylate, mesna tablets, and zoledronic acidMartin H Cohen
Division of Oncology Drug Products, Center for Drug Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland 20857, USA
Oncologist 7:393-400. 2002..Information provided includes rationale for drug development, study design, efficacy and safety results, and pertinent literature references...
- Developing treatments for inborn errors: incentives available to the clinicianMarlene E Haffner
FDA Office of Orphan Products Development, Food and Drug Administration, Rockville, MD 20857, USA
Mol Genet Metab 81:S63-6. 2004..Today, international support for rare disease research is providing stimulus and motivation to overcome the financial barriers and encourage development of treatment for very rare diseases throughout the world...
- Enzyme replacement therapy for Fabry disease: lessons from two alpha-galactosidase A orphan products and one FDA approvalRobert J Desnick
Department of Human Genetics, Box 1498, Mount Sinai School of Medicine, Fifth Avenue at 100th St, New York, NY 10029, USA
Expert Opin Biol Ther 4:1167-76. 2004..The process also highlighted important issues in the evaluation of drugs to treat life-threatening genetic diseases for which the pathological basis is well-defined...
- Adoption agentCarmen Peota
Minn Med 88:8-9. 2005
- Gleevec for the treatment of chronic myelogenous leukemia: US. Food and Drug Administration regulatory mechanisms, accelerated approval, and orphan drug statusMartin H Cohen
Division of Oncology Drug Products HFD 150, Center for Drug Evaluation and Research and Office of Orphan Products Development, Office of the Commissioner, Food and Drug Administration, Rockville, Maryland 20857, USA
Oncologist 7:390-2. 2002..The purpose of this report is to summarize FDA regulatory mechanisms, i.e., accelerated approval and orphan drug regulations, that have permitted patients to receive this drug as rapidly as possible...
- Increasing the use of orphan drugs in clinical practiceSally Anne Hulton
Birmingham Children s Hospital NHS Trust, Birmingham
Hosp Med 65:400-3. 2004..Over the next few years, orphan drugs will probably be increasingly adopted into everyday clinical practice, partly because of genomic stratification...
- [Orphan drugs: some legal, ethical and economics aspects]J Y Pabst
, , 74, route du Rhin, B.P. 24, 67401 Illkirch-Graffenstaden Cedex, France
Rev Epidemiol Sante Publique 49:387-96. 2001..This document implements the dispositions available to pharmaceutical firms inciting them to invest in the development of orphan drugs...
- Understanding orphan drug regulations: an EU and U.S. comparative analysisAurelie Grienenberger
Regulatory Affairs and Drug Development, Voisin Consulting, Paris, France
J Biolaw Bus 7:58-61. 2004..An update of the orphan drugs designations is provided as well as the upcoming challenges that orphan regulations will meet with the development of pharmaco-genomics and personalized medicines...
- EU to review rare disease drugs market exclusivityCormac Sheridan
Nat Biotechnol 22:1061. 2004
- An overview of drug development in the United States and current challengesSharon Wyatt Moore
Medical and Regulatory Affairs, Clinical Trial Management Services, Inc, Bristol, TN 37620, USA
South Med J 96:1244-55; quiz 1256. 2003..Although the ultimate goal is to bring safer and more effective medical products to patients in a timely manner, multiple challenges face those who participate in drug development...
- Diagnostic challenges and new therapies for rare lysosomal storage diseasesBarbara Hesselgrave
Case Manager 14:48-52. 2003
- From club drug to orphan drug: sodium oxybate (Xyrem) for the treatment of cataplexyDavid E Fuller
Orphan Medical, Inc, Minnetonka, Minnesota 55305, USA
Pharmacotherapy 23:1205-9. 2003..This program has been successful in satisfying the needs of patients and physicians while ensuring responsible distribution of the drug...
- The Food and Drug Administration's Office of Orphan Products Development: incentives, grants, and special designations speed therapies for orphan diseasesMarlene E Haffner
The FDA Office of Orphan Products Development and Public Health Service, USA
Retina 25:S89-S90. 2005
- New products highlight ambiguity of orphan drug lawBrian Reid
Nat Biotechnol 21:6-7. 2003
- This Dutchman is flyingNoshua Watson
Fortune 147:89-90. 2003
- Medicines for children licensed by the European Agency for the Evaluation of Medicinal ProductsA Ceci
Department of Pharmacology and Human Physiology, University of Bari, Italy
Eur J Clin Pharmacol 58:495-500. 2002..We also considered any possible difference between the EMEA and the Food and Drug Administration (FDA) paediatric medicines evaluations...
- PPPs succeeding in tackling neglected diseasesSimon Frantz
Nat Rev Drug Discov 4:796-7. 2005
- EMEA approves OGS drug rejected by FDAPeter Mitchell
Nat Biotechnol 20:858-9. 2002
- A breakthrough in R&D for neglected diseases: new ways to get the drugs we needMary Moran
London School of Economics and Political Science, London, United Kingdom
PLoS Med 2:e302. 2005
- Congress, the FDA, and the fair development of new medications for childrenRoss E McKinney
Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA
Pediatrics 112:669-70. 2003
- The European rare diseases therapeutic initiativeAlain Fischer
Department of Pediatric Immunology, Necker University Hospital, Paris, France
PLoS Med 2:e243. 2005
- Orphan anticancer drug rejectedAdrian Burton
Lancet Oncol 4:524. 2003
- Availability of and access to orphan drugs: an international comparison of pharmaceutical treatments for pulmonary arterial hypertension, Fabry disease, hereditary angioedema and chronic myeloid leukaemiaCarl Rudolf Blankart
German Research Center for Environmental Health, Munich, Germany
Pharmacoeconomics 29:63-82. 2011....
- Adverse drug reactions to anthelminticsHaleh Bagheri
Department of Pharmacology, Midi Pyrenees Center of Pharmacovigilance, Faculty of Medicine, Toulouse University Hospital, Toulouse, France
Ann Pharmacother 38:383-8. 2004..Anthelmintics are commonly used in tropical areas, but are also prescribed in Western countries with other climates. However, pharmacoepidemiologic studies of these drugs are rare...
- Anecdotal therapiesL E Millikan
Department of Dermatology, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
Adv Exp Med Biol 455:407-11. 1999..The formulation of a low concentration of zinc pyrithione seemed unusual, and this truly was an anecdotal approach, using a homeopathic dosage of a commonly used p..
- Gaucher disease: clinical profile and therapeutic developmentsTimothy M Cox
Department of Medicine, University of Cambridge, Cambridge, UK
Biologics 4:299-313. 2010....
- Development of antidotes: problems and strategiesLadislaus Szinicz
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstr 11, 80937 Munich, Germany
Toxicology 233:23-30. 2007....
- A review on clinical management and pharmacological therapy on hereditary haemorrhagic telangiectasia (HHT)Roberto Zarrabeitia
Hospital de Sierrallana, Reference Hospital for HHT in Spain, Torrelavega, Santander, Spain
Curr Vasc Pharmacol 8:473-81. 2010..In this context, the use of hormones, immunosuppresants and anti-angiogenic agents are under preclinical study in our laboratory...
- A decade of safety-related regulatory action in the Netherlands: a retrospective analysis of direct healthcare professional communications from 1999 to 2009Peter G M Mol
University Medical Center Groningen, Groningen, The Netherlands
Drug Saf 33:463-74. 2010..This challenge has led to a life-cycle approach but, so far, few data are available on post-approval safety issues requiring regulatory action...
- Prader-Willi syndrome in TaiwanHsiang Yu Lin
Department of Pediatrics, Mackay Memorial Hospital, and Mackay Medicine, Nursing and Management College, Taipei, Taiwan
Pediatr Int 49:375-9. 2007..Prader-Willi syndrome (PWS) is a congenital disorder caused by absent expression of paternal genes in 15q11-13 affecting multiple systems. The information concerning the clinical features of this genetic disorder is incomplete in Taiwan...
- Regulatory considerations for developing drugs for rare diseases: orphan designations and early phase clinical trialsAnne R Pariser
Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
Discov Med 11:367-75. 2011....
- Access to orphan drugs despite poor quality of clinical evidenceAlain G Dupont
Commission for Reimbursement of Medicines, Vrije Universiteit Brussel, Brussels, Belgium
Br J Clin Pharmacol 71:488-96. 2011..We analysed the Belgian reimbursement decisions of orphan drugs as compared with those of innovative drugs for more common but equally severe diseases, with special emphasis on the quality of clinical evidence...
- Drug development for orphan diseases in the context of personalized medicineGeorge J Brewer
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich 48109 0534, USA
Transl Res 154:314-22. 2009....
- Limitations of drug registries to evaluate orphan medicinal products for the treatment of lysosomal storage disordersCarla E M Hollak
Department of Internal Medicine, Division of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
Orphanet J Rare Dis 6:16. 2011..We argue that disease specific (rather than drug specific) registries, supervised by independent clinicians are urgently needed for the best long-term evaluation of treatments of these rare diseases...
- 'Orphan drugs' in cardiology: nadolol and quinidineGiuseppe Inama
Division of Cardiology, Cardiocerebrovascular Department, Ospedale Maggiore, Crema, Italy
J Cardiovasc Med (Hagerstown) 11:143-4. 2010..We hope that scientific societies can influence healthcare and pharmaceutical institutions, in order to restore the availability of two cardiovascular drugs that are extremely important in the care of arrhythmic patients...
Research Grants72
- Dichlorphenamide vs Acetazolamide for Periodic ParalysisRobert C Griggs; Fiscal Year: 2010..abstract_text> ..
- Microarray analysis of gene expresion in T. cruziRick Tarleton; Fiscal Year: 2006..Completion of this study will provide valuable data on the expression of genes in T. cruzi, especially the many that are "hypothetical," and provide a starting point for elucidating the functions of these genes. ..
- IMMUNOREGULATION IN EXPERIMENTAL CHAGAS DISEASERick Tarleton; Fiscal Year: 2006..cruzi infection, including the extent of polyclonal activation in the infection and the degree to which an over-aggressive immune response contributes to disease. ..
- Dichlorphenamide vs Acetazolamide for Periodic ParalysisROBERT GRIGGS; Fiscal Year: 2009..abstract_text> ..
- Dichlorphenamide vs Acetazolamide for Periodic ParalysisROBERT GRIGGS; Fiscal Year: 2007..abstract_text> ..
- CD8+ T cell and Trypanosoma cruzi infectionRick Tarleton; Fiscal Year: 2007..cruzi will be determined and the biological significance of the effect of this antagonism of the generation and effector function of CD8+ T cells will be determined. ..
- Plan forTrial to find Optimum Steroid Regimen in Duchenne Muscular DystrophyROBERT GRIGGS; Fiscal Year: 2006....
- IMMUNOREGULATION IN EXPERIMENTAL CHAGAS DISEASERick Tarleton; Fiscal Year: 2007..The results of these studies also have strong parallels with human T. cruzi infection and implications for possible treatment of infection and disease in infected subjects. ..
- Nervous System Channelopathies: Pathogenesis & TreatmentROBERT GRIGGS; Fiscal Year: 2007..They may also offer a window for understanding common disorders likely to be caused by CNS channel mutations/dysfunction such as migraine and epilepsy. ..
- EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASEROBERT GRIGGS; Fiscal Year: 2007..Training facilities include: the General Clinical Research Center, Clinical Trials Coordination Centers, Biostatistics Department, Gorell Molecular Biology Laboratory, Center for Aging & Developmental Biology. ..
- PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*George Brewer; Fiscal Year: 2007..Abstract Not Provided ..
- Novel treatment for muscle disease: Fueling the pipeline and finding the productROBERT GRIGGS; Fiscal Year: 2006....
- Dichlorphenamide vs Acetazolamide for Periodic ParalysisROBERT GRIGGS; Fiscal Year: 2004....
- IMMUNOREGULATION IN EXPERIMENTAL CHAGAS' DISEASERick Tarleton; Fiscal Year: 1993....
- HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENTPeter Hotez; Fiscal Year: 2002..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
- TREATMENT OF EBV ASSOCIATED LYMPHOPROLIFERATIVE DISEASEDenis Moss; Fiscal Year: 2002....
- CD8+ T CELLS AND TRYPANOSOMA CRUZI INFECTIONSRick Tarleton; Fiscal Year: 2002..The completion of this project could provide the information and the tools necessary to determine whether or not targets of the anti-T. cruzi CTL response would be useful as vaccines. ..
- North Carolina Collaborative PPRU NetworkRoss McKinney; Fiscal Year: 2004..6) To train physicians and pharmacologists in clinical and developmental pharmacology: the centerpiece will be a 3-year pediatric pharmacology fellowship. Drs. Brouwer and Lindley (UNC) will lead this program. ..
- Novel Designs and Outcome Measures for Bench to Bedside Research on NMDROBERT GRIGGS; Fiscal Year: 2007..In this effort to provide new treatments for neuromuscular disease, this conference will help to further public health goals. ..
- Integrated Human Research Subjects Protection ProjectRoss McKinney; Fiscal Year: 2003..abstract_text> ..
- Pathogenesis and treatment of the periodic paralysesROBERT GRIGGS; Fiscal Year: 2004....
- CD8+ T cell and Trypanosoma cruzi infectionRick Tarleton; Fiscal Year: 2009..cruzi will be determined and the biological significance of the effect of this antagonism of the generation and effector function of CD8+ T cells will be determined. ..


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Reward Credit Cards And The Fine Print
Reward Credit Cards And The Fine Print
Tuesday, June 22, 2010 - 7:48 PM
Reward and cash back credit cards are often not as rewarding as you first thought. You have to read the fine print to know the gotchas. This
blog post at the FinancialHighway.com
lists 8 common lines of fine print. The one that annoys me is #8 Value of rewards points. How much is a point? I much prefer simple cash back.
Ken Tumin
5,471 posts since
Nov 29, 2009
Rep Points: 125,634


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Why is there a zombie in the Daytime studio?
The sequel to the hit action-strategy adventure with over 30 Game of the Year awards is here.
Join Crazy Dave on a crazy adventure where you'll meet, greet and defeat legions of zombies from the dawn of time to the end of days. Amass an army of powerful new plants, supercharge them with Plant Food and power up your defenses with amazing new ways to protect your brain.
Bernie Yee the creator stops by to show us how it works and talk about the life of a game creator.
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6/2/2013-Been Here Before
(May 31, 2013)
Hillary Clinton is another victim, er, subject I need to update. My caricature of her goes back to when her husband was president and that was a very long time ago. She too has changed, but I can't just use her old caricature and add lines to it. There's more to it than that. And speaking of Hillary, I don't think she's going to run for president. I think her age would be a factor, and that's the Democratic Party's dilemma. There are no trans-continental rising young stars. President Obama was the last who had national name recognition.
The path could be wide open for a slimmed down Republican Chris Christie if he can run fast enough to leave that crowd of right wing losers behind.


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Lenawee County Sheriff Jack Welsh says a farmer spreading lime in the field made a gruesome discovery near an abandoned barn on Scott Hwy., north of Station Rd., Friday afternoon.
He says, "we found a body of a female, it appeared to have been here awhile."
Welsh tells 13abc the body appears to have some signs of decomposition.
According to Welsh, the death appears suspicious.
Welsh didn't talk specifics by said there were at least two indicators that tell them this may not have been an accident.
"We'll be looking for a missing persons case and hopefully that won't take very long."
There was one local case that detectives are looking into as a possible connection. In fact, a Sylvania Township detective was on scene to see if the woman matched the description of Kathy Sackrider, 59. She was last seen at her daughter's home in the township back in September. Law enforcement says it is too early to tell if its her.
New software will allow radar to scan storms near ground every 2 minutes instead of 4.


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Last Update: Wednesday, August 27, 2014
|TRAVEL AND ADVENTURE- La Dolce Vita: Art, Arias and Gastronomy in Parma, Italy
|Written by Victoria Looseleaf Creative Syndicate
|Thursday, 31 May 2012 01:33
Whether it's music, art, architecture, food, fashion or fantastic natural scenery, Italy's got it. And for those who've done the Rome/Venice/Florence route and don't want the crowds, Parma is one of the country's best-kept secrets. Located in the northern Emilia-Romagna region between Milan and Bologna in the Po River Valley, this sleepy town of 170,000 is a magical destination, its eponymous Parma ham and Parmigiano-Reggiano cheese only part of its appeal.
Not for nothing did French writer Stendhal (nee Marie- Henri Beyle) pen his masterpiece, "The Charterhouse of Parma." Following in Stendhal's footsteps, a good place to start is in the lovely older section of town at the Piazza Duomo, where the 12th- century Romanesque cathedral houses the author's favorite artist and Parma's most illustrious painter, Correggio. It was here that he decorated the interior of the dome with his Renaissance fresco, "Assumption of the Virgin," a kaleidoscopic swirl of angels that seems to glow at the top of the cupola. Moving to the south transept of the cathedral visitors will find Benedetto Antelami's earliest work, the glorious carved frieze "Descent From the Cross."
Steps away are the Bishop's Palace, an impressive structure framed by Romanesque arches; a Gothic bell tower; and the Baptistery, Antelami's six-story octagonal edifice of pink-and-cream Verona marble. Often referred to as the most original work of the Italian Romanesque era, the Baptistery was built at the beginning of the 13th century and features dazzling paintings of biblical tales, as well as a set of figures representing the signs of the zodiac.
A short walk away is the centrally located Garibaldi Plaza, a hub of shops, cafes and restaurants, many with umbrella-shaded terraces. A stroll through the verdant Ducal Park, an example of a French style garden, leads to the Ducal Palace, Town Hall and the Governor's Palace and then on to Parma's National Gallery. Once a stately home to the Farnese family, this vast site, which also includes the national archaeological museum, was restored after World War II, with the Gallery boasting a number of royal portraits, as well as paintings by Correggio, da Vinci, El Greco and others.
Most unusual, perhaps, is the re-creation of the 16th-century Teatro Farnese. Originally built to celebrate a marriage between the Medicis and Farneses, the cavernous 4,000-seat horseshoe- shaped wooden structure plays host to occasional operas and concerts. Music being central to Parma's cultural scene, the resplendent Teatro Regio, a 19th-century neoclassical theater rich in gold and stucco work, also offers concerts throughout the year. With its elegantly designed ceiling sporting figures representing comedy, tragedy and romantic drama and 20 rows of orchestra seating surrounded by five tiers of boxes, this intimate venue lends itself to a first-class listening experience. A recent recital by tenor Leo Nucci is proof that Verdi is alive and well today.
And why not? Giuseppe Verdi, composer of 28 operas, including such beloved works as "Aida" and "Rigoletto," was born in the neighboring village of Roncole, near Busseto. And while Parma celebrates the composer every October with a festival bearing his name, Verid's music can be heard year-round in Busseto. The 16th-century Villa Pallavicino, now site of the Verdi National Museum, is where the composer lived and worked. Displaying relics such as his piano, composition books and walking sticks, the villa also houses the magnificent 300-seat Teatro Verdi, where the composer may never have actually attended a concert but did contribute 10,000 lire toward the construction of the theater in which he maintained a personal box.
Another legendary musician and native Parma son was conductor Arturo Toscanini, whose birthplace and residence is also a museum. Filled with batons, concert photos and memorabilia, the house is notable for its library of all the recorded works Toscanini ever conducted. Crowds are never a problem here, as no more than 25 visitors at a time are permitted inside the museum to watch an hourlong biography of the maestro for whom the NBC Symphony Orchestra was created in 1937.
A trip to Parma, Italy's food basket, cannot be complete without visits to Parma ham and Parmesan cheese producers, the latter dotting the area with centuries- old dairy farms. Handcrafted from partly skimmed milk that is added to whey then aged from 18 to 24 months in large storage areas, the Parmigiano-Reggiano cheese is branded before being sold in giant wheels, each weighing up to 90 pounds.
As for Parma's famous prosciutto, the word comes from the Latin, prae exuctus, which means drained. In the 14th century, locals began using salt from nearby Salsomaggiore, which, thanks to the presence of sodium, bromine and sulfur, prevented the growth of bacteria, allowing the meat to keep longer. The breezy hills south of Parma are ideal for curing hams, which are aged up to 10 months, then branded with the fivepointed crown of the old duchy of Parma. Ham devotees might also wish to visit the Museum of Parma Ham to delve further into the history, techniques and recipes from the origins to the present.
Verdi, who was said to favor culatello, a refined prosciutto not available in the United States, would have loved Massimo Spigarolli's farmrestaurant, Al Cavallino Bianco. The Spigarolli pigs are raised like royalty, with cured hams hanging in the cellar bearing nametags such as Princes Charles and Albert, of England and Monaco, respectively. Spinach-stuffed tortelli and anolini soup along with salumi dishes make lunch nothing less than a feast.
Regional wineries and castles are also popular, with Lamoretti vineyards a source of delicious Lambrusco. Drinking a glass is the perfect start for a tour of the spectacular Torrechiara Castle, a 15th-century fortress that overlooks the valley. Its numerous rooms include the erotic "Golden Chamber," a series of colorful frescoes depicting scenes of love.
|Last Updated on Thursday, 31 May 2012 01:54


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I felt safer walking downtown before the crosswalks were put in! People apparently can't read or just simply don't care.
I stand at the curb at the crosswalk close to the Java Hut, waiting for people to stop so that I can get across. But despite the "It's the Law" signs, they keep going. I have come close to getting hit.
Tobi L. Peck


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Save to My Recipes
Dilly New Potato Salad with Summer Sausage
Published: July 2012 Servings: 6-8
- 4 pounds 1'-diameter new potatoes, preferably red-skinned
- Kosher salt
- 1/2 pound good-quality summer sausage, cut into 1/2' rounds
- 6 tablespoons (3/4 stick) unsalted butter, cut into small cubes
- 2 tablespoons whole grain mustard
- Freshly ground black pepper
- 3 tablespoons coarsely chopped fresh dill plus more for garnish
- 2 tablespoons chopped fresh chives
Nutritional Information
7 servings, 1 serving contains:
- Calories (kcal) 400
- Fat (g) 18
- Saturated Fat (g) 9
- Cholesterol (mg) 50
- Carbohydrates (g) 47
- Dietary Fiber (g) 3
- Total Sugars (g) 0
- Protein (g) 11
- Sodium (mg) 390
PREPARATIONView Step-by-Step Directions
Place potatoes in a large pot. Add water to cover by at least 1"; salt water generously. Bring to a boil over medium-high heat; immediately reduce to a low simmer. Simmer potatoes until tender, about 20 minutes. Drain potatoes, reserving 1/2 cup cooking liquid.
Meanwhile, heat a grill pan over high heat. Add sausage rounds and cook on one side until charred in spots, about 5 minutes (do not grill second side). Let sausage cool. Cut sausage into 1/2" cubes and set aside.
Combine potatoes, butter, mustard, and 3 Tbsp. potato cooking liquid in a large bowl. Toss, adding cooking liquid by teaspoonfuls as needed, until butter lightly coats potatoes with a glossy sauce. Season potatoes to taste with salt and pepper.
Using a potato masher, lightly crush the potatoes (you want them to just break open but not fall apart). Add 3 Tbsp. dill, chives, and half of sausage; toss once. Scatter remaining sausage over top and garnish with chopped dill.
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A collection of news and information related to Consumer Goods Industries published by this site and its partners.
Top Consumer Goods Industries Articles
Displaying items 23-33
New Labels, But Same Old Maple Syrup
States Going All In On Gambling
No Reason For Connecticut To Go It Alone On GMO LabelsStory | May 31, 2013 | 2:50 PMThose calling for labeling all food containing genetically modified organisms are angry with a bill passed by the state House last week that would require GMO labels — but with a big "if." Five other states, including New Jersey and at least one...
Don't Label Genetically Engineered Food
Gun Making Part Of Connecticut's FabricStory | Mar 29, 2013 | 4:16 PMFrom coast to coast, politicians and pundits quickly grasped the irony when the shooting tragedy at Sandy Hook Elementary School in Newtown landed Connecticut, the home and birthplace of the American firearms industry, at the center of a national...
Genetically Engineered Food Needs LabelsStory | Apr 5, 2013 | 4:06 PMIf there's one thing that stands out for me during my 25 years in Connecticut, it was the quiet but delicious return of good food and local farms. For readers who are less than 40 years old, please remember, there were no farmers markets in the state...
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Used Furniture Company Transfer Enterprises Thinking Big For Future
Disposable Bags Are Facing Scrutiny, From The Legislature To SupermarketsStory | Mar 7, 2008Since their debut in supermarket checkout lines in 1977, plastic shopping bags have become the tote of choice. Back then, plastic seemed like a good option: a way to stop cutting down so many trees to make all those paper bags. They take less energy...


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Life as a mom who has her hands full
If you are looking for the most unique and most talked about birthday party ever…look no further. My uncle sent this to me and I knew immediately that I had … Continue reading
Does your child love Candy Land? If you are looking for a unique and fun birthday party for your 3 or 4 year old…look no further. Throwing your own Candy … Continue reading
I get this question quite a bit…along with the question "are you guys done yet?" My usual response is "no, not yet..I am still waiting to feel done". This response … Continue reading
How do you get your child to drink more water?? We all know that water is healthy to drink and certainly much better than sugary soft drinks and juices, but … Continue reading
I've added several Top 10 lists to my website this week. Check them out. Top 10 dinosaur movies for kids who love dinosaurs Top 10 Train Books for kids Top … Continue reading
Check out this new page I added to my website. Teach your child how to swim. If you are looking to teach your preschooler or toddler how to swim, this … Continue reading
Is your 3 year old boy or 4 year old boy not listening? Do you often wonder if it is a matter of hearing or wills that you are battling? … Continue reading
In San Antonio, a mother and her boyfriend were arrested for trying to sell her 5 year old daughter for sex. The unidentified informant contacted the FBI and they were … Continue reading
I read an absoultely amazing article today. David Gilmour let his teenage son drop out of high school and watch movies. Shocking I know, but in all reality it was … Continue reading
Every day I have the same internal battle..do I put my 3 year old down for a nap or put her to bed early that night. If she doesn't take … Continue reading


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Tioga High School Virtual Yearbook
Upcoming Class Reunions
- Class of 2005 reunion
(10 year reunion)
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(20 year reunion)
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(25 year reunion)
- Class of 1985 reunion
(30 year reunion)
- Class of 1980 reunion
(35 year reunion)
- Class of 1975 reunion
(40 year reunion)
Click Here to Register
Patrick Blackwell
Class of 2004
Karen Campbell
Class of 1979
All Tioga High School Alumni
The names listed below are alumni who have been searched for on this site from Tioga High School in Tioga, Louisiana. If you see your name among the Tioga High School graduates, someone is looking for you! Register to let other graduates of Tioga High School find and contact you. We realize that a Tioga High School year book may be hard to find so registering to complete your school's Virtual Yearbook may be the next best thing to finding Tioga High School yearbooks. The list of names is also useful for getting together a Tioga High School reunion if you don't have a complete list of the students from your graduating class of Tioga High School.
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By Rod Rose
The Lebanon Reporter
---- — A Lebanon man who died after his small SUV hit a full-size pickup head-on, was on his way home from a trip to a store that he made because he couldn't fall asleep. Darrin K. Ashcraft, 47, 1000 block of Lafayette Avenue, was taken by Boone County EMS to Witham Memorial Hospital, where he was pronounced dead after the 5:17 a.m. Thursday crash on Witt Road, about six blocks from his home. "According to family members, he said he couldn't sleep and went to Wal-Mart," said Lebanon Police Department Lt. Brent Wheat. "He went just to pick up some items, and was on his way back home." For more of the story, see Friday's Lebanon Reporter.


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Public Safety Announcement from The Ohio State University
This evening The Ohio State University Police Division issued the following announcement:
The Ohio State University Police Division has information, originating from a chat site, that referenced a potential threat of shooting or explosive violence focused on a 'cafeteria' or other unspecified area of campus on Monday (04/08/2013) on The Ohio State University Columbus campus. We are taking this information seriously and continue to aggressively investigate. We will have extra police and security presence on and around campus dining facilities. We have the assistance of federal, state and local law enforcement agencies.
This information is being sent so that the university community is aware and to ask assistance in reporting any suspicious persons, behavior or packages today or in the future. We take this opportunity to remind everyone: If you See Something, Say Something -- dial 9-1-1 in an emergency or 292-2121 to reach the Police Division's non-emergency line.
At this point, we do not know if this new information is related to the threat received last week.
Updates will be posted on: emergency.osu.edu">
Media: Contact Ohio State University Police Deputy Chief Richard Morman at 292-2121
Or Amy Murray, email@example.com


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Saranac Lake, New York - April 11, 2011
A Saranac Lake, N.Y., homeowner made a gruesome discovery this past weekend when a body turned up in their backyard.
Police have identified the remains as those of local man, Gary Sklaryk. The 55-year-old disappeared from his home on Jan. 2. Numerous searches turned up no signs of the missing man.
Police say Sklaryk suffered from a medical condition and that the homeowner discovered the body when the snow melted. An autopsy is scheduled for a later date, but police are not considering his death suspicious.
WCAX News
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Burlington, VT 05406-4508
Primary Phone: 802-652-6300
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Welcome to the 2014 junior club volleyball season in Badger Region. As the season proceeds, we'll be taking time each month to chat with one of our clubs. This month, our spotlight is on the Northern Trailblazers.
The Northern Trailblazers are located in Antigo, Wisconsin and run by Club Directors Valerie McCarthy and Kevin Fischer.
The Northern Trailblazers started in 2009 with four teams: girls' 13U, girls' 15U and two girls' 17U teams. Since then, the Trailblazers have expanded to 10 teams and hosts volleytots/MINI Volleyball programs.
Every club is a little bit different. According to McCarthy, the Norther Trailblazers club program focuses on skill development and life lessons.
"Northern Trailblazers Volleyball Club believes that every child should be offered the opportunity to develop the skills that will enable them to excel and compete successfully at the interscholastic, regional and/or national level of youth volleyball," McCarthy said. "Along with teaching each player life lessons and/or skills to help them achieve their goals in life. Volleyball, or any sport, is taught on and off the court."
Volleyball is a sport taught on and off the court, and it teaches life lessons to players, coaches and parents alike. McCarthy cherishes the opportunity to watch her players grow during their time in the program. It makes the long hours she spends behind-the-scenes worth it.
"There is so much hat needs to be done to run and maintain a good club volleyball program," McCarthy said. "With the distance of the schools in the area, it is hard to draw High School or College coaches. The closest college is UW Marathon in Wausau. This is one of the main reasons we offer to send our coaches to the coaching clinics that Badger Region or USAV has available."
The coaching education opportunities that the Northern Trailblazers provide their staff are beneficial to all members of the program.
"We are happy that our coaching staff takes advantage of this opportunity," McCarthy said. "And we are happy they have returned to coach for the Trailblazers. Our members are fortunate to have such devoted coaches that are willing to better their coaching education, philosophies and techniques."
One of the ways the Trailblazers focus on developing their skills is at Wednesday "Skills & Drills/Open Gyms." Players from all age groups come in for extra court time. McCarthy stated that it is a pleasure to watch her players of all ages interact and learn about volleyball together.
When asked about her favorite memory as a club directory, McCarthy pointed towards a time when her team lost. You heard us right. Lost.
"In 2011, I was coaching our 18's team at March Mania in the WI Dells," McCarthy said. "We were in the Championship game Sunday on Court 1 playing I-80 Blues from Iowa. The girls were very excited to play on Court 1 with so many spectators surrounding the court. It was a very close match; we went point for point with I-80 Blues. We lost, but the thing I remember the most is the way my players looked and acted after the match. They knew they played their hearts out and left it all on the court. They knew they lost the the match but also knew they won. It was such a pleasure to see that they understood what it is like to compete. You can win and still lose, but more importantly you can lose and still win."
As the Northern Trailblazers look to the future, they hope to continue fielding teams in each age group. McCarthy wants to see two teams per age group in the 14U and older age levels, along with the Volleytots and MINI Volley programs.
Wishing the Northern Trailblazers and all their parents, coaches and staff luck during the 2014 Badger Region Volleyball season.