text:
Greenspring Drive, 1900 block, between Feb. 1 and Sept. 12. Three computer towers and two computer monitors were stolen from a vacant office suite.
Hathaway Road, unit block, between 10 a.m., Sept. 2 and 5 p.m. Sept. 7. A trimmer, leaf blower, grill cover 17-inch rimes and tires and 20-inch rims and tires were stolen out of a shed.
Hathaway Road, unit block, between 10 a.m., Sept. 2 and 5 p.m. Sept. 7. A lock was destroyed and a trimer was stolen out of a shed.
Timonium Road, unit block, between 6:30 p.m., Sept. 6 and 4:30 p.m., Sept. 10. A Husqvarna leaf blower, Craftsman Miter Saw and Craftsman 4-Cycle Weed Trimmer were stolen. A padlock was also destroyed in the heist.
If you have questions about the weekly crime log, or police activity in your neighborhood contact editor Nick DiMarco at firstname.lastname@example.com or by phone at (443) 621-2174.
Follow Lutherville-Timonium Patch on Facebook and Twitter. Or get the daily newsletter.
2012 Lutherville-Timonium Incident Tracker:Incident # of Times Reported in 2012 Notes/Link (The latest)Burglary (Including attempted) 69
See above.
Protest 2
A group protested the war in Afghanistan.
Armed robbery (Including attempted)
A man robbed Walgreen's with a crowbar. Robbery 2 112 Oxycodone pills were stolen. Suspicious condition 1 Anti-Semitic material was found in local neighborhoods. Destruction of property 2 Street signs vandalized with swastikas.
Possession of drugs or paraphernalia 2
A man stole prescription drugs from a relative.
Petty theft 1 A thief stole several items from unlocked cars.
Editor's Note: The Incident Tracker lists reports, compiled by Patch, relevant to Lutherville-Timonium, filed at the Baltimore County Police Department Precinct 7 in Cockeysville. The number of reports listed may not be 100 percent accurate based on a number of factors (and an accounted for week in May).


text:
Villa Serenity at Aviana Resort - Brand New 4 Bed/ 3 bath in Disney Area
- bedrooms 4
- baths 3
- sleeps 10
- pool yes
- hot tub no
- pets allowed no
- type Villa
- community Aviana Resort
rates (USD)
/ night
$ 840 - $ 1,260 / week
vacation rental description
Serenity is a brand new executive Orlando Florida vacation home
which features state of-the-art living ... 4 bedrooms, 3 bathrooms,
heated private swimming pool, designed for all types of parties –
the young and old alike, it is at the same time either a retreat of
tranquillity or a children's paradise of fun.
Set overlooking a stunning natural conservation area location with
much, much more to offer and only 15 minutes from Walt Disney World.
This home, built on a large lot is located in the tranquil
surroundings of the new Aviana Resort, Orlando, Florida. Aviana is
an upmarket gated community and private resort.
An oasis of swaying palms, rich green foliage and exotic
flowers, Aviana Resort offers a relaxing retreat from the hustle and
bustle of Orlando's exciting attractions which makes it a fantastic
place to stay as it is one of the best residential community resorts
close to Walt Disney World's four theme parks. This makes it a much
sought after location for your Florida holiday. All other major
theme parks such as both Universal Studios parks and SeaWorld are
easily accessible.
The large extended poolside offers complete privacy and is
surrounded by lush tropical landscaping overlooking a natural
conservation area and a lake to the right hand side in the distance.
The luxury patio furniture is ideal for alfresco dining.
This is the one to rent!
Our Orlando vacation rental villa offers over 2000 square ft of
fully air conditioned flexible living space. It comprises of 4 large
double bedrooms including 2 master suites and 2 twin rooms. There
are 2 spacious sitting areas, comfortable designer sofas in the
family room and formal living room which is also a sofa bed that
will sleep another 2 guests and 2 dining areas – a café/bistro area
or you can choose the formal dining area.
The luxurious pool measures 26' x 12' and is fully screened. It also
has a child safety fence for your family's protection. The pool can
be heated if required and has underwater illumination.
The holiday rental villa has luxury facilities and equipment to
attend to all your likely vacation needs including a top-of-the-
large LCD Widescreen High Definition Television and DVD system.
Additionally there is a Playstation 2 games console with a selection
of games to entertain children of all ages! We also have an Ipod
docking station for your own music.
We have had a professional Games Room installed which has been
decorated with motor racing flags and collectable retro metal signs
capturing 'years gone by'. For your entertainment there is an 8ft x
4ft pool table with high quality above table lighting, a
professional standard soccer table and a fun electronic dartboard.
To take a rest whilst you play there is a 50's style chrome pub
table and two high bar stools. The floor is covered with luxurious
cushioned vinyl floor tiles.
Quality prevails throughout from the ceramic tiling to the designer
furniture and the Floridian Artwork on the walls to give the villa
that true, special Orlando Feel….. you will not be disappointed with
your choice of vacation rental villa.
Orlando Florida is known for its fabulous golf courses. For keen
golfers the vacation rental villa is located really close to many
courses that have been designed by top PGA golfers and major title
winners including Greg Norman's Championsgate 36 hole award winning
golf course and the Disney golf courses. For keen shoppers, the
designer malls are nearby.
For the comfort and safety of all guests
there is no smoking permitted within the holiday rental villa.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 07-9-2014 at 5:00 AM.
email owner view full calendar
Justin Wootten +44 (0)2083194469
villa rental amenities
Aviana Resort
Aviana sits on US17-92, approximately 5.9 miles south of the
Champions Gate 1-4 exit.
Take I-4 west to exit 58 (the Reunion/Champions Gate exit) and make
a left turn. Go down a few miles and make a right turn onto Old Lake
Wilson Road, then turn left onto Hwy 54 and make another right onto
17/92. Aviana is about 1 mile down and will be on the right. Turn in
on Hart Road to the entrance of Aviana Resort.
Aviana Resort
"Your own tropical oasis."
An oasis of swaying palms, rich green foliage and exotic flowers,
Aviana Resort offers a relaxing retreat from the hustle and bustle
of Orlando's exciting attractions. The community 6,500 square foot
state of the art clubhouse will eventually be surrounded by a large
sparkling pool, Spa, splash area, tot lot and sand volleyball court,
features a cyber café, and arcade. Additionally you will also be
free to enjoy the complimentary Gymnasium/exercise room.
To ensure that you keep together with friends and family members,
there is also the facility of a gathering room and helpful staff in
the reception area at hand to assist you with any requirement you
may potentially have.
Gourmet Kitchen
Designer Oak Cabinetry
Spacious Double Bowl Sink with Vegetable Sprayer
Generous Pantry for Food Storage
30 inch Oven/Range
18 cu. Ft. Fridge freezer with Icemaker
Waste Food Disposal Unit
Coffee Making Facilities
Laundry Room with Washer and Gas Dryer
Ironing Board and Iron
Vacuum Cleaner
All Linen and Towels provided
Entertainment Facilities
Television in each of the Master Bedrooms
LCD High Definition Widescreen Television in the Family Room
DVD in the Family Room
Play station 2 in the Family Room
Radio in Kitchen
Luxury Poolside Furniture
Safety Facilities
Movable Pool Safety Fence to stop small children falling into the
pool by accident
2 Personal Anti-Theft Safes – 1 in each master suite
Child Facilities
High Chair
The Setting of Villa Serenity
Villa Serenity is situated at the quiet back part of the complex
giving you the opportunity to enjoy a peaceful relaxing and private
Villa Serenity's pool has a westerly facing aspect which means that
you will be able to maximise the sunlight throughout the day.
Additionally for any child's protection there is a removable child
fence that will restrict entry to the pool to stop any worries that
parents will have around accidents.
We have had the surrounding area around the pool – the deck extended
so that means that you will have more space to relax on the sun
furniture. As the pool faces a protected conservation area, your
privacy is protected as well as a fantastic view. Some villas have
walling or back onto other villas…….this is not the case at Villa
Serenity – sit or laze around and admire the view during a fantastic
Floridian Sunset whilst you sip your favourite drink.
Family Room
This is the "Chill Out" area. Either slouch out on the luxury
designer sofas and enjoy some peace and quiet, or entertain
yourselves with the fantastic multimedia available. As you can see
the family room opens out through the sun drenched patio doors into
the decking and pool area. The whole house has had the flooring
tiled to a very high standard
Children of all ages will love the challenges of the Play station 2
Games console. Otherwise our 32 inch LCD High Definition Television
will blow your mind We have a small collection of DVD's for your
use or you may wish to pick up a bargain at one of the many Malls to
watch at your leisure then take home
Games Room
We have installed a fun games room to give you additional
entertainment. The same level of quality has been used in this room
too. We have luxury cushioned vinyl tiles on the floor and have
decorated the walls with auto memorabilia and motor racing flags -
this gives a unique feel to the room. The games room has been
equipped to the highest level, there is a high spec 8ft x 4ft
American Pool Table with over table lighting , a professional
standard Foosball/Soccer table and even an electronic dartboard.
Take the weight off your feet by resting on one of the retro 50's
style chrome pub stools whilst you sip a drink.
Master Bedroom
The Master bedroom is an example of stylish contemporary design. You
will find furniture crafted in Maple with nickel accents. There is a
Queen Size bed with 2 bedside cabinets. A Dresser with a matching
mirror completes the room. If you require peace and quiet to watch
your favourite TV programme, you can retreat to this room and watch
your own television. The room also has a massive walk-in closet. For
your security you will find a small digitally coded safe for your
valuables within the closet. The floor is covered in a luxury carpet.
Master Bedroom – En-suite Bathroom
A luxury Villa would not be complete without en-suite bathrooms. Our
Master Bedroom has a large en-suite bathroom with a walk in shower
that is big enough for 2 people! Additionally there is a sumptuous
deep corner bath to relax, soak and enjoy.
The bathroom is well lit as there is a perfect mix of decorative and
functional lighting surrounding the vanity unit and basin.
Master Bedroom 2
The second master bedroom is furnished in the same contemporary
modern style as the main suite, so………..no arguments about who gets
which bedroom on arrival!
You will find all the same facilities such as a TV, chest of Drawers
and a mirror. You also get a built in closet. For your security you
will find a small digitally coded safe for your valuables within the
closet. The floor is covered in a luxury carpet.
You couldn't call it a master suite without an en-suite bathroom, so
there is also this facility as well. This is quite rare in a lot of
villas. In the en-suite there is a Bath/shower with basin and a
vanity unit.
Twin Bedrooms
Each of our twin bedrooms are decorated exactly the same. Yet again
light modern lightwood furniture has been used. The bedroom has been
kept quite neutral so that either a child or an adult will feel at
home in the room. You will find a bedside cabinet as well as a built
in closet for your clothes and possessions. The floor is covered in
a luxury carpet.
Gourmet Kitchen
The high spec kitchen will make your stay an absolute delight. The
kitchen has a fantastic professional but homely feel to it with its
Designer Oak Cabinetry. The food preparation area consists of a
Spacious Double Bowl Sink with a Vegetable Sprayer and Waste Food
Disposal Unit to help you prepare the perfect family meal, should
you choose not to eat out at one of the many fabulous restaurants.
Storage space is not a problem as there is also a Generous Pantry
for Food Storage. You will be able to cook by using the large 30
inch Oven/Range or the Microwave. Every American home has the must
have "American Style" Fridge freezer with Icemaker.
When you have finished for the day, don't wash up………it's your
holiday – put your feet up and let the top of the range dishwasher
take the strain.
Additionally you will not have to search for a launderette as you
will have your own facilities with a Washer and Gas Dryer.
Everything has been taken into consideration with this kitchen;
everything that a cook and family will require has been thought of
and will be provided.
Kitchen Nook
If you want the convenience of eating a quick snack or a take out
meal in a less formal setting, this is the place for you. This
café /bistro style area will fit the bill as it is situated just
next to the kitchen.
Living Room/Dining Room
A more formal setting without the excitement of the entertainment
area and multimedia equipment. Relax here and read your favourite
book or …………….just get away and have some peace and quiet away from
the kids whilst they enjoy themselves in the main family room.
The formal dining table is spectacular enough for any formal family
dinner or special occasion.
activities and attractions in Disney Area Central Florida
The location is fantastic for all types of guest -
Disney is only 15 minutes away, Seaworld 20 Minutes away and The
Universal Parks are only 20 Minutes away.
There are a number of World Class golf courses in the area designed
by top PGA Pros.
The Gulf Coast beaches of Cocoa Beach and Daytona Beach are only 90
minutes away as is the Kennedy Space Centre.
vacation rental rates
Please see the Website for all dates and rates as we offer various
discounts such as -
• Early Bird Special = Book more than 12 months in advance to
receive a 10% discount
• Late booking Discount = Book less than 8 weeks to booking
date and receive a 10% Discount
• Introduce a Friend Incentive = If you introduce a friend and
they book a date with us you will receive a 10% discount on the cost
of your stay.
• Long Stay Discount = Contact us for this offer (at least
An Example of our rates are listed below –
Start Date End Date Price Per Week $ Price Per Day $
01/01 - 06/01 1260 180
07/01 - 31/01 840 120
01/02 - 28/02 840 120
01/03 - 31/03 840 120
01/04 - 21/04 1260 180
22/04 - 30/04 840 120
01/05 - 21/05 840 120
01/06 - 30/06 840 120
01/07 - 31/07 917 131
01/08 - 31/08 917 131
01/09 - 30/09 917 131
01/10 - 31/10 917 131
01/11 - 18/11 840 120
19/11 - 30/11 917 131
01/12 - 17/12 840 120
18/12 - 31/12 1260 180
Please check our website for up to date prices and offers
Justin Wootten +44 (0)2083194469
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center
Top things to do in Disney Area
- Soarin at Epcot
- Test Track at Epcot
- The Disney Boardwalk
- Phantasmic at Hollywood Studios
- Toystory Mania
Top things to do on a budget
- Ride the Monorail at Disney
- Chill at Downtown Disney
- Disney Waterparks
- Shopping at Factory Outlets
- Use coupons to get discounts in restaurants
Top things to do with a family
- Magic Kingdom
- Epcot
- Animal Kingdom
- Hollywood Studios
- Seaworld
Justin Wootten , owner

subset: commoncrawl


text:
Lion trying to attack baby at zoo?
cancercrossDec 3 2013, 152 views
This male lion pounced as soon as we put our 10 month old daughter down in front of the glass alone. She is oblivious, but he seems pretty serious!
Press the button
if you liked the video! Thank you!
Awesome Baby Gives A Thumbs-Up In Ultrasound Photo? Wow, Unbelievable!by ProphesyGW
Sep 2 2014, 1 views
I'm Amazed By Just Watching This Machine Working! I'd Like To Work It There!by cancercross
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Chef Proves That We've Been Eating Sushi Wrong This Whole Time!by cancercross
Aug 28 2014, 634 views
I Thought This Car Has Two Wings, But What Those Actually Are Stuns Me!by cancercross
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How to Peel an Orange the Russian Way! This is so smart!by heavensky
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This Nun Asked Guys For Help. But Why They All Failed Made My Jaw Drop!by ProphesyGW
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She records an album each year as a gift for her family each year. This time she really nailed it!by heavensky
Jul 25 2014, 1,142 views
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Jul 24 2014, 3,399 views


text:
MADISON (WKOW) -- During the extremely cold days this week, organizations that help the homeless are working even harder to make sure people have a warm place to go.
Porchlight is expecting more than 170 people to seek shelter with them the next couple of days, and they say no one will be turned away.
Winter poses particularly difficult times for people without homes, as they have to carry their personal belongings through the snow and extremely cold temperatures, according to Porchlight executive director Steven Schooler.
Porchlight will have two daytime warming centers, one at Safe Haven and another at their Hospitality House on Martin Street. They will be open from 8:30 a.m. to 4:30 p.m. Organizers have also extended the hours of the emergency drop-in shelter to open until 9:00 a.m., when the Central Madison Public Library opens.
Monday morning, a van will pick people up starting from the Salvation Army Shelter on East Washington Avenue, stop at the drop-in shelter on West Washington Avenue, then bring them to the Hospitality House. Routes will vary in the afternoon to include other locations such as the Dane County Jobs Center, Bethel Lutheran and the Catholic Multicultural Center, among others.
Schooler says people can encourage any homeless people they see to go to one of these centers to find transportation to the warming shelters.
More, the Hospitality Center is taking donations in the form of warm winter gear and twin-sized bedding. People can also donate at justgive.org to provide the homeless with shelter, meals, laundry and any additional support.
Thank you for participating in our poll. Here are the results so far:


text:
Tailgating Making Strides at BYU
After visiting the Grove last year for the season opener, a few BYU fans were inspired to start a tailgating tradition of their own. They even mention their attempts to create a "Grove-like tent city" complete with good food and hospitality. Obviously there are some difficulties with this, not the least of which is the prohibition of alcohol by the Mormon faith and on the BYU campus, but they're working to make sure this is a success.


text:
Point B's entrepreneurial spirit and ownership culture is widely recognized by the consulting industry and business luminaries. Our culture attracts results-focused leaders and supports them in doing their best work for our clients.
Point B Named One of Largest Healthcare Management Consulting Firms Read More
PSBJ Names Point B Top Three in the Large Company category for Best Places to Work. Read More
OCBJ Names Point B Top 2 Best Place to Work Read More
Point B Denver Awarded as Top 3 Healthiest Employers of 2014 Read More
Point B's Ben Burke was named one of Consulting magazine's Top 25 Consultants. Read More
Garrett Kephart is a Rising Star in Consulting magazine's Inaugural Award Read More
Point B Named One of the Top Two "100 Best Companies to Work for in Oregon" Read More
Modern Healthcare Named Point B One of Top Healthcare Consulting Firms Read More
Point B Named One of the Top Four "Best Firms to Work for" Read More
Point B Recognized by LABJ as Best Place to Work for 3rd Time Read More
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The Puget Sound Business Journal honors Point B for its philanthropic efforts. Read More


text:
Funding opportunities
Stem Cell-Based Targeted Immune Therapy for Cancer
Funding Type:
Disease Team Research I
Grant Number:
Funds requested:
$17 452 288
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Science has made great progress in the treatment of certain cancers with targeted and combination therapies, yet prolonged remissions or cures are rare because most cancer therapies only inhibit cell growth and/or reduce such growth but do not stop the cancer. The study investigators propose to develop two Investigational New Drug (IND) applications within the grant period for the genetic modification of hematopoietic (blood) stem cells (HSC) from patients with advanced forms of an aggressive skin cancer (malignant melanoma) to genetically redirect the patient's immune response to specifically attack the cancer. Evaluation of effectiveness and immune response during treatment will use imaging with Positron Emission Tomography (PET) scans. The HSC treatment approach has been validated in extensive studies in the laboratory. The investigators of this grant have recently initiated a clinical trial where adult immune cells obtained from blood are genetically modified to become specific killer cells for melanoma. These cells are administered back to patients. The early data from this study is encouraging in terms of the ability to generate these cells, safely administer them to patients leading to beneficial early clinical effects. However, the adult immune cells genetically redirected to cancer cells slowly decrease over time because they do not have the ability to self-renew. The advantage of the proposed HSC method over adult blood cells is that the genetically modified HSC will continuously generate melanoma-targeted immune killer cells, providing prolonged protection against the cancer. The 1st IND filing (year 2/quarter 2) will use the modified HSC in end-stage melanoma patients. By the end of year 4, we will expand our efforts to a 2nd IND for a new engineered HSC clinical trial that will increase the specificity of the HSC to other cancers. The therapeutic principles and procedures we develop will be applicable to a wide range of cancers and transferrable to other centers that perform bone marrow and HSC transplants. The aggressive milestone driven IND timeline is based on our: 1) Research that led to the selection and development of a blood cell gene for clinical use in collaboration with the leading experts in the field 2) Our wealth of investigator initiated cell based clinical research and our Human Gene Medicine Program 3) Experience receiving a combined 15 investigator initiated INDs for research with 157 patients in Phase I and II trials 4) Ability to leverage significant institutional resources of on-going HSC laboratory and clinical research and co-support with over $1M of non-CIRM funds to pursue the proposed research goals, including the resulting clinical trial
Statement of Benefit to California:
Cancer is the leading cause of death in the US and melanoma incidence is increasing the fastest (~69K new cases/year). Treatment of metastatic melanoma is an unmet local and national medical need (~9K deaths/year) striking adults in their prime (30-60 years old). Melanoma is the second greatest cancer cause of lost productive years given its incidence early in life and its high mortality once it metastasizes. The problem is severe in California in large populations with skin types sensitive to the increased exposure of ultraviolet light. Most frequently seen in young urban Caucasians, melanoma also strikes other ethnicities with steady increases of acral melanoma in Latinos and African-Americans over the past decades. Although great progress has been made in the treatment of certain leukemias and lymphomas with targeted and combination therapies, few options exist for the definitive treatment of late stage solid tumors. When cancers like lung, breast, prostate, pancreas, and melanoma metastasize beyond surgical boundaries, prolonged remissions or cures are rare and most cancer therapies only inhibit cell growth and/or reduce such growth but do not stop the cancer. Our proposal which contains 2 INDs for the genetic modification of the patient's own hematopoietic stem cells (HSC) for the immunotherapy of end-stage melanoma allowing sustained production of cancer-reactive blood cells, has the potential to address a significant and serious unmet clinical need for the treatment of melanoma and other cancers, increase patient survival and productivity, and decrease cancer related health care costs. The advantage of the proposed HSC methodology over our current work with peripheral blood is that genetically modified stem cells in the patient's body will continuously generate melanoma-targeted blood cells providing prolonged protection against the cancer. During the grant period we will also develop and produce a GMP quality second IND vector expressing a T cell receptor for NY-ESO, an antigen expressed by 10-30% of all cancers, thereby broadening the applicability of this approach. The therapeutic principles and procedures developed here will be applicable to a wide range of cancers. GMP reagents and clinical protocols developed by our team will be transferrable to other centers where bone marrow and peripheral blood stem cell transplantation procedures are done. Our institution, with its college and multiple professional schools, receives over $900M in extramural research support with a major economic impact throughout the region. The proposal will build upon a strong foundation of basic and clinical research and further solidify on-going institutional collaborations that will further link the activities of four premier research institutions.
Review Summary:
The goal of this proposal is to engineer autologous hematopoietic stem cells (HSCs) to express tumor antigen-specific T cell receptors (TCRs) for transplantation into melanoma patients as an immunotherapeutic treatment. This research team has validated this approach and the efficacy of the first target antigen clinically using mature T cells and proposes to enhance the therapeutic benefit through the use of stem cells and by improving the gene therapy vector. The proposed therapy would be available to melanoma patients of the appropriate HLA haplotype with tumors expressing the targeted tumor antigens. Patients receiving the therapy would be appropriately conditioned prior to the adoptive transfer of engineered cells and would undergo post-adoptive transfer treatments to boost lymphocyte expansion. The vector would be designed to support Positron Emission Tomography (PET)-based imaging of the adoptively transferred cells and include a "suicide gene" as an additional safety mechanism. The applicants also propose to increase the potential impact of this therapeutic on melanoma patients by developing a second vector targeting a different tumor antigen. The second vector could be utilized to initiate a polyclonal anti-tumor immune response through adoptive transfer of both populations of engineered HSCs. The lead candidate for the second target antigen is expressed in melanoma and by a wide range of cancers and could potentially broaden the applicability of this therapy. The reviewers found this application to be a well-reasoned proposal targeting a highly resistant and generally fatal disease from an outstanding team of investigators with a proven track record. However, the reviewers were not convinced that the use of HSCs would offer a significant clinical advantage and were concerned that the applicants did not address several regulatory elements critical to the feasibility of the preclinical plan and the filing of the two proposed Investigational New Drug (IND) applications with the FDA. The reviewers were moderately enthusiastic about the significance of and scientific rationale for this therapy. While they agreed that the impact of advances in this therapeutic approach would be significant and that melanoma presents an unmet medical need, they questioned the number of patients this therapy could potentially reach. The potential patient population is limited by numerous factors as the patients would be restricted to those with a specific HLA haplotype who have tumors expressing the targeted antigens and who are able to tolerate the conditioning regiment. The scientific rationale for the proposed immunotherapy is sound, but reviewers were not convinced that the rationale for utilizing HSCs was well supported. The applicants included a wealth of data validating the approach, but there was little data provided to support the hypothesis that a renewing population of cancer-reactive T cells would provide a significant clinical benefit to melanoma patients as compared to the clinical trial this group recently initiated. The reviewers appreciated the ample preliminary data providing proof of concept for the use of engineered TCRs in treating melanoma and demonstrating the ability to apply this technology in HSCs. The clinical data was compelling and supportive for the anti-melanoma activity of cells transduced with a vector targeting the first proposed antigen. However, there was little preliminary data to support several feasibility and safety concerns. For example, the reviewers noted the lack of data addressing thymic selection following adoptive transfer of HSCs, immune evasion strategies employed by cancer cells, and the potential adverse effects viral transduction might have on other immune cells differentiated from transduced HSCs. The reviewers also questioned the lack of data demonstrating how the suicide gene might be utilized in potentially quiescent HSCs and its potential impact on the immune competence of the human host. The reviewers found the preclinical plan to lack several critical elements to achieve two IND filings within the four-year timeline. The reviewers did not agree with the applicant that the FDA would not require toxicology studies in animals with the GMP lentiviral construct and believed that the proposed use of two different vector systems in one patient would present a significant safety concern for the FDA. The regulatory expert suggested that it would be important to approach the FDA with data from animal models demonstrating the safety of this approach. The reviewers were also concerned that the use of self-renewing HSCs provided an additional regulatory burden that the applicants did not address. There was no apparent plan to generate data demonstrating the safety of this approach with HSCs, and the applicants did not address the difficult prospect that long-term tracking of the patient population might be necessary when using HSCs. The reviewers were also not confident that the FDA would allow the use of the PET component of the viral vector. There is no clinical benefit to the PET component, and it is likely to be perceived as increasing patient risk due to potential immunogenicity of the PET gene and the additional genetic modifications to the vector that are necessary for its inclusion. Furthermore, while the PET reporter gene can be used for non-invasive in vivo tracking, this does not offer an outcome measurement. The clinical endpoints the applicants hope to demonstrate are unclear. Despite these numerous regulatory concerns, the reviewers found the preclinical plan targeting the development of the HSCs transduced to express TCRs reactive to the first target antigen to be logical and achievable with reasonable milestones and timelines. However, this was not the case for the development of the vector targeting the second proposed antigen. The reviewers commented that this second part of the preclinical plan was not clearly delineated, and there was not sufficient data or details to indicate that increasing the immune response to the lead antigen target would be effective in treating melanoma patients. The milestones were vague, and the reviewers agreed that the only evidence that the timelines could be achieved was the excellent track record of the team. The reviewers also noted that the first component of the application was significantly stronger than the studies proposed for the second antigen target. The applicants indicated that the majority of the studies aimed at developing the first target antigen are already supported by outside sources, and it was therefore unclear to reviewers why CIRM funds were necessary for that portion of the proposal. The reviewers considered the qualifications of the primary investigator (PI), the Co-PIs, and the disease team to be the central strength of the proposal. The PI is highly qualified to lead this team of senior investigators and the collaborations are long standing and solid. The senior investigators on this team have impeccable track records with extensive experience in IND-enabling research. The group has all the necessary expertise and is perfectly suited for this research. The reviewers commented that there is clear commitment from the institutions and all the critical resources are in place. The reviewers praised the existing infrastructure and leadership plan and noted the inclusion of a project manager and a strong external advisory committee composed of the world experts in immunotherapy for cancer treatment. Overall, the reviewers felt that the applicants did not provide sufficient preliminary data to support their approach using HSCs and did not provide sufficient detail to support the feasibility of the research plan. This deficiency outweighed their great regard for the impressive quality of the assembled team and potential impact that advances in immunotherapy could have on cancer treatment.
- John Rasko


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The kingdom had been founded by the Normans , who had liberated Sicily from the Arabs in the 11th century, and then united the various Lombard duchies and Byzantine captaincies by the early 12th. By the early 13th century, under Frederick II von Hohenstaufen , it was the most flourishing and progressive kingdom in Europe. But Frederick had run afoul of the popes, and shortly after his death the popes gave it to the Angevins, who confirmed their owndership on the battlefiled in 1266 and 1268. The history of Angevin Naples was one of steady decline. Sicily broke off in 1282, as the result of an insurrection ("the Sicilian Vespers") jointly sponsored by the Byzantine Emperor and the King of Aragon, who took over the property.
Robert of Anjou (231), King of Arles, is the grandson of the first Angevin King of Naples. His heir is Giovanna, his granddaughter. [[Giovanna is not the heir for Arles, however, even though she is the closest relative. Giovanna could inherit Provence and Naples, both of which are technically fiefs of the Pope. Robert needed a male heir for Anjou and he didn't have one when he died). The situation of the 60 year old Robert of Anjou (King of Arles and Naples) is a complex one. King Robert is the great-grandson of Louis VIII of France (in the direct male line,) through the latter's youngest son, Charles, who became King of Naples by papal dispensation in 1265, and on the battlefield in 1266 and 1268. So, his Salic lands would escheat (return) to his closest male relative in the senior line when his branch of the family dies out. This would be the;
1.King of France (although there were a few other, lower ranking, contenders) if the latter is a Capetian. However, the Capetian dynasty (the direct male line) ended in 1328 with the death of Charles the IV. That brought our own Philip VI to the throne, a great-great-grandson of Louis VIII (through the female line.) However, Arles had been declining as a separate kingdom for some time and was, in this period, a de facto part of France. As France formed from the wreckage of Charlemanges ninth century empire, Arles was one of many kingdoms barbarians had carved out of the Roman empire since the fifth century. Indeed, about all Arles had to distinguish itself with was that the city of Arles was once the capital of the Roman province covering most of the same territory as the present kingdom of Arles. However, after Robert d'Anjou died without a male heir, the pretense of Arles being a separate kingdom was dropped and the Arles lands became French. Naples was never firmly held by the French and for several generations after the Hundred Years War French armies periodically campaigned in Italy to get it back. They never really succeeded.
2. Humbert de la Tour du Pin (100), through a very complex relationship which makes him "residual heir" if Robert's other heirs die out.
3. Alfonso XI of Castile (8), through his great-grandfather Alfonso X's mother, a cousin to Frederick II of Hohenstaufen .
4. Pedro IV Berenguer (197), King of Aragon, through his great- grandfather Pedro III, who wed the grand-daughter of Frederick II of Hohenstaufen.


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Rabastan Lestrange
From LeakyPedia
Rabastan Lestrange was a pure-blood wizard, brother of Rodolphus and Slytherin student at Hogwarts School of Witchcraft and Wizardry. He was a Death Eater who fought in the First Wizarding War. The Lestranges were considered to be among Lord Voldemort's most loyal and trusted servants, and the only ones who searched for him after his first downfall.


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Homemade ice cream is always a hit with family and friends on holidays or any other day!
Kellsey loves everything about summer, with the exception of triple digit temperatures. But even the...
An abnormal fear of accidentally poisoning people from home canning mistakes has kept me from trying...
A paragraph or two on what different people consider comfort foods.
On the family farm, our Christmas tree was always a pasture ever-green put in a five-gallon bucket filled with sand or rocks to hold it upright. Our homemade ornaments were quite simple, but we thought they were beautiful-strung popcorn, chains of paper, either construction paper cut in strips or colored with Crayolas, a few treasured glass balls (wish I still had them), and of course, icicles. I can remember having clip-on candle holders with candles but can never remember lighting the candles. Mother probably realized what a fire hazard they would be. We hung wreaths in the windows and "honeycomb" bells in the doorways. Our tree was always in the parlor, since we didn't heat that room, so we placed it near the see-through "French doors" in order to enjoy it.
Breakfast and outdoor farm chores were done before we were allowed to open any presents. Our presents were quite simple, mostly clothes that we really needed, maybe a doll or homemade doll clothes, books or games. We had an orange and some hard candy in our socks. There were gifts from the grandparents too, nothing elaborate by today's standards to be sure, but we were always proud and appreciative of whatever we received.
Christmas dinner was always special. I never remember having turkey, usually pork or roast beef or maybe roast chicken and dressing, fluffy mashed potatoes, hot homemade rolls with lots of butter and jelly, home-canned green beans or scalloped corn with oysters, gelatin salads and pumpkin or mincemeat pie after dinner. We stuffed ourselves with homemade candy, fudge, divinity and peanut brittle. After a fun-filled day with various grandparents, uncles, aunts and cousins, it was time to bundle up and do the evening chores: feed the chickens and the hogs, gather the eggs and milk the cows. After that another. Christmas was tucked away In our memory.
Ann Wyer Corydon, Iowa
Back in 1955 a call went out from the editors of the then Capper's Weekly asking for readers to send in articles on true pioneers. Hundreds of letters came pouring in from early settlers and their children, many now in their 80s and 90s, and from grandchildren of settlers, all with tales to tell. So many articles were received that a decision was made to create a book, and in 1956, the first My Folks title – My Folks Came in a Covered Wagon – hit the shelves. Nine other books have since been published in the My Folks series, all filled to the brim with true tales from Capper's readers, and we are proud to make those stories available to our growing online community.
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A new medical school will soon call Wausau home. Wausau beat out four other communities in Central Wisconsin to host the campus.
It's been a long road to get to this point. The Medical College of Wisconsin has long wanted to expand to our area.
Now, college leaders have decided Wausau is the best location.
"We liked the high visibility of the Liberty Mutual building in Wausau. We thought Wausau itself provided an outstanding environment for students to learn and live," Medical College of Wisconsin CEO John Raymond said.
Health care leaders in Central Wisconsin agree.
"We were delighted that the Medical College chose Central Wisconsin. As far as I'm concerned, any one of the locations would have been fine," Ministry St. Clare's President Mary Krueger said.
Wisconsin rapids, Marshfield and Stevens point were all in the running. But community leaders say it's not about where the college lands.
Multiple mayors tell Newsline9 they're just happy these students will be in the area.
The multi-year program is a combination of in-classroom learning and field training--that's where the other communities will come in.
"We really do need the entire region to be fully engaged to make this work," Raymond told Newsline 9.
Another site was announced for the Green Bay region. College leaders say the combined cost of the two campuses will be more than $20 million.
"There are many under served parts of this state that do not have enough physicians and we thought this model would help to address that by immersing the students in the community we hope they serve," Raymond added.
"The value of having a medical school here is really to bring physicians to this part of the state," Krueger told Newsline 9.
College leaders expect to have the school up and running by July 2015. But they say there's a lot of work to be done by then.
The medical school is set to take in 15 students the first year, and hope to expand to 25 students in each class as the college grows.
A big name retailer has its eyes on a spot in Wausau, according to city council members.


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The votes are in and it's not too surprising that five Westport restaurants received top-five rankings in their respective categories.
According to the 2013 Best Restaurants rankings by Connecticut Magazine, Bobby Q's Barbecue and Grill on Main Street in downtown Westport earned a top nod for barbecue in Connecticut. The Whelk, located on the water on Riverside Avenue, was named one of the top five new restaurants, along with a designation for best seafood. The Whelk also received honorable mentions for best overall restaurant and best desserts.
Rizzuto's, in the Saugatuck section of town across from Bridge Square, was recognized in the top five for family restaurants and Oaxaca Kitchen on Post Road East was rated among the best Mexican / Latin restaurants by the magazine's critics. Tengda Asain Bistro received a top-five ranking for best Asian.
Interested in Westport's news, events, community bulletins, blogs and businesses? Sign up for the free Westport Patch daily newsletter, "like" us on Facebook and follow us on Twitter.
Honorable mentions were given to the Dressing Room for best brunch and best American, Artisan for most romantic, LUXE Modern Wine & Cocktails for best cocktails, Matsu for best Asian and best sushi, Tegenda for best sushi, DaPietro's for best Italian.
In Greenwich, the Eleven14 Restaurant in Riverside was named one of the top five new restaurants, along with a designation for best hotel for dining. Another Greenwich landmark, L'escale at the Delamar on Greenwich Harbor, received a top five ranking for best outdoor dining.


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Garlicky Kale Recipe
This warm and zippy side dish features fresh kale and sweet raisins. "It tastes wonderful served hot or cold," comments Clara Coulston from Washington Court House, Ohio.
- 3 cups water
- 2 bunches kale, trimmed and coarsely chopped
- 4 garlic cloves, minced
- 1 teaspoon olive oil
- 1/2 cup golden raisins
- 1/4 cup pitted ripe olives, sliced
- 1/4 teaspoon salt
- 1/4 teaspoon crushed red pepper flakes
- In a large saucepan, bring water to a boil. Stir in kale. Cover and cook for 6-8 minutes or until almost tender; drain and set aside.
- In a large nonstick skillet coated with cooking spray, cook garlic in oil for 1 minute. Stir in the raisins, olives, salt and pepper flakes; cook 1 minute longer. Stir in kale; cook for 3-4 minutes or until tender. Yield: 6 servings.
Originally published as Garlicky Kale in Light & Tasty August/September 2006, p63
Reviews for Garlicky Kale
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Reviewed May. 14, 2014
Quick and easy to make, delicious, and great as left-overs!
Reviewed Apr. 8, 2013
I make this recipe over and over. If my grown kids come by for a visit and there's any leftovers, they eat it up. I use green olives instead of ripe ones. the salty mixes well with the garlic and sweetnes of the raisins. Craisins work well also.
Reviewed Apr. 26, 2010
A delightful combination of flavors--and several immunity-boosting ingredients.
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Normal accident
If interactive complexity and tight coupling – system characteristics – inevitably will produce an accident, I believe we are justified in calling it a normal accident, or a system accident. The odd term normal accident is meant to signal that, given the system characteristics, multiple and unexpected interactions of failures are inevitable. This is an expression of an integral characteristic of the system, not a statement of frequency.
Normal accidents occur when complex machine elements malfunction, either individually or interactively, and human operators misjudge what is happening and respond with actions that accelerate the deterioration of the situation.


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Tameside Hospital criticised
A highly critical report into the care of a man in Greater Manchester says his treatment was so bad he was denied any chance of survival.
Reginald Baird died of septicemia after doctors at Tameside Hospital failed to remove abscesses on his liver. The hospital has since carried out a full investigation.
Amy Welch reports.


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Rutgers is announcing that it will join the Big Ten at an afternoon news conference Tuesday on its campus in Piscataway, N.J.
Big Ten Commissioner Jim Delany will be joined by Rutgers University President Robert Barchi and athletic director Tim Perenetti.
Rutgers will be leaving the Big East, where it has been competing since 1991. The move follows Maryland's announcement on Monday that it was departing the Atlantic Coast Conference to join the Big Ten in 2014. Rutgers will be the Big Ten's 14th member.
Rutgers also plans to join its new conference in 2014, though the Big East requires 27 months' notification for departing members. The Scarlet Knights will have to negotiate a deal with the Big East to leave early.
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For Sale: Two Coan 8", 5200 stall converters
Ad #182161356 Posted:2014-03-17 15:43:39
This ad expired 84 days ago.
One conv has Coan's Super Sprag, the other one has Coan's upgraded OEM sprag.Have (2) Coan 8", 5200 stall, PG spline torque converters. Both converters have never been installed since being freshened by Coan. Both are set up for an 1/8" thick mid-plate. Both were built for my 406 small block, tube chassis bracket car. Sold car, engine and trans.
Above Added: Mon March 17, 2014, 3:46 pm EST
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Watch Law & Order: Special Victims Unit
Law & Order is one of America's favorite franchises. This police procedural has spawned numerous spin-offs, including Law & Order: Special Victims Unit. Each version of Law & Order focuses on different detectives. The detectives' personal lives and reactions to cases are as compelling as the crimes themselves. SVU focuses on Detectives Stabler and Benson. Like the other Law & Order shows, SVU frequently bases episodes on real-life crimes that are in the news.
Detective Elliot Stabler was one of the most popular characters on the show. A married man with several children of his own, he occasionally took cases personally, displaying a violent temper. Detective Stabler struggles to deal professional with the criminals he encounters. He admits to fantasizing about hurting the people he arrests and is almost removed from the force when he reveals this. His experience raising his own children has made him good at relating to child victims he encounters while working cases. Despite his bad temper and occasional poor judgment, many viewers can relate to Detective Stabler and his disgust at the criminals he arrests and interviews.
Detective Olivia Benson is Detective Stabler's partner for most of the show. She balances his anger towards criminals with her own compassion for sexual victims. Detective Benson eventually reveals that her childhood was not happy due to an alcoholic mother and an absent father. Benson's tragic past led her to work for the Special Victims Unit. Many female viewers see Detective Benson as a positive role model.
Other detectives and support staff feature heavily in the series. Like other Law & Order shows, the detectives have close relationships with the NYPD's medical examiner and the New York District Attorney's office. Viewers love watching the characters grow over the course of the show, but the ultimate draw of Law & Order is seeing each week's criminal caught and brought to justice. SVU adds something extra to the formula by showcasing "especially heinous" crimes in every episode.
Watch Full Episodes of Law & Order: Special Victims Unit
Law & Order: Special Victims Unit Full Episode Guide
- Episode 23 - Spring Awakening
Amaro's reckless behavior once again makes him the target of Internal Affairs, and this time he is forced to pay the consequences. Meanwhile, an online ad for escorts leads to the rape and robbery of several male tourists, and one of the suspects has an unexpected connection to Sergeant Benson.
- Episode 22 - Thought Criminal
The SVU use an aggressive approach when they go undercover and target a successful photographer with a secret life.
- Episode 21 - Reasonable Doubt
T.V. producer Frank Maddox is accused of molesting his 8 year old daughter. Maddox's wife wants justice for their daughter, but refuses to cooperate with the police.
- Episode 20 - Post-Mortem Blues
With inconclusive evidence, Benson is investigated for William Lewis' death.
- Episode 19 - Beast's Obsession
- Episode 18 - Downloaded Child
- Episode 17 - Criminal Stories
- Episode 16 - Gambler's Fallacy
- Episode 15 - Gridiron Soldier
- Episode 14 - Comic Perversion
- Episode 13 - Wednesday's Child
- Episode 12 - Betrayal's Climax
- Episode 11 - Jersey Breakdown
- Episode 10 - Amaro's One-Eighty
- Episode 9 - Psycho/Therapist
- Episode 8 - Rapist Anonymous
- Episode 7 - Military Justice
- Episode 6 - Dissonant Voices
- Episode 5 - October Surprise
- Episode 4 - Wonderland Story
- Episode 3 - Internal Affairs
- Episode 2 - American Tragedy
- Episode 1 - Surrender Benson / Imprisoned Lives
- Episode 23 - Her Negotiation
- Episode 22 - Brief Interlude
- Episode 21 - Poisoned Motive
- Episode 20 - Traumatic Wound
- Episode 19 - Girl Dishonored
- Episode 18 - Born Psychopath
- Episode 17 - Legitimate Rape
- Episode 16 - Undercover Blue
- Episode 15 - Funny Valentine
- Episode 14 - Deadly Ambition
- Episode 13 - Secrets Exhumed
- Episode 12 - Monster's Legacy
- Episode 11 - Criminal Hatred
- Episode 10 - Beautiful Frame
- Episode 9 - Presumed Guilty
- Episode 8 - Dreams Deferred
- Episode 7 - Lesson's Learned
- Episode 6 - Vanity's Bonfire
- Episode 5 - Friending Emily
- Episode 4 - Manhattan Vigil
- Episode 3 - Acceptable Loss
- Episode 2 - Twenty-Five Acts
- Episode 1 - Lost Reputation/Above Suspicion
If You Like Law & Order: Special Victims Unit, Then Try...
Most Popular Law & Order: Special Victims Unit Episodes
Law & Order: Special Victims Unit News
An up-and-coming singer is beaten by her famous boyfriend, but she won't assist the prosecution. This episode is said to mirror the relationship of Rihanna and Chris Brown. See what the controversial episode is all about.
Rollins' sister makes a return visit, and this time she's battered and pregnant. When the situation escalates, Rollins resorts to dire actions, leading Internal Affairs to open up an investigation.
Detective Olivia Benson reunites with an old colleague to reopen a 25-year-old cold case. But things don't go as planned. Will Olivia have to betray a friend in the name of justice?
Mike Tyson and Ed Asner guest star as the detectives struggle to uncover a past history of sexual abuse. Reggie Rhodes is set to be executed, but can some recent revelations set him free in time?
The rapper who stirred up trouble between Ice-T and Coco is reportedly shopping around photos of Coco that will prove much more damaging to her marriage than the last batch.
Give Dick Wolf's baby credit where it's due: not every show survives long after losing an iconic lead. Despite Christopher Meloni's season 13 departure, NBC has given a 14th "Law & Order: SVU" season the thumbs-up for Fall 2012. "I'll be back. I can't leave this show. I'm having too much fun," said star Mariska Hargitay.


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Historic South Cerney village hall re-thatched (From Wilts and Gloucestershire Standard)
Get involved: send your pictures, video, news and views by texting WGS NEWS to 80360, or email us
Historic South Cerney village hall re-thatched
12:00pm Sunday 14th October 2012 in News By Ian Craig
ONE of the Cotswolds' most historic buildings is prepared for everything the winter elements can throw at it as the roof of South Cerney's village hall was re-thatched.
The Grade II listed building, thought to be the only thatched village hall in Gloucestershire, was built as an agricultural barn several hundred years ago and was donated to the village for conversion into a village hall in the 1920's.
Although the Village Hall Committee had a sum of money saved up for the work, a further £20,000 was needed, which was provided thanks to a generous grant of £13,832 from the Gloucestershire Environmental Trust Company and landfill tax contributions from Cory Environmental.
Comments are closed on this article.


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OmniVision Stock Gaps Up On Today's Open (OVTI)
NEW YORK (TheStreet) -- Shares of OmniVision Technologies (Nasdaq:OVTI) were gapping up Friday morning with an open price 12.9% higher than Thursday's closing price. The stock closed at $16.08 Thursday and opened today's trading at $18.16. The average volume for OmniVision has been 2.7 million shares per day over the past 30 days. OmniVision has a market cap of $811.4 million and is part of the technology sector and electronics industry. Shares are up 31.4% year to date as of the close of trading on Thursday. OmniVision Technologies, Inc. engages in designing, developing, and marketing semiconductor image-sensor devices worldwide. The company has a P/E ratio of 6.9, above the average electronics industry P/E ratio of six and below the S&P 500 P/E ratio of 17.7. TheStreet Ratings rates OmniVision as a hold. The company's strengths can be seen in multiple areas, such as its largely solid financial position with reasonable debt levels by most measures, reasonable valuation levels and notable return on equity. However, as a counter to these strengths, we also find weaknesses including unimpressive growth in net income, weak operating cash flow and poor profit margins. You can view the full OmniVision Ratings Report. Get more investment ideas from our investment research center. Interested in other stocks that are gapping up? Get free SMS text alerts sent to you when the action happens by texting UP to 95370 or select from multiple alert options.
OmniVision Technologies Inc Stock Price
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For 10 years Extreme Health USA has been offering only 12 cutting edge products, not like other companies that do not specialize. All of Extreme Health USA products have clinical studies to verify their effectiveness. We have also been selling these exact products for over 10 years to doctors. This verifies how effective their formulas are. They also offer these same products to children, which verify how safe the products are.
Don't fret! Check out these suggested similar and related items below. Happy shopping!
Extreme Health USA - Probiotics 120 Billion - 2.5 oz. (60g)
Extreme Health USA ProBiotics 120 Billion formula promotes proper balance to your intestinal tract and absorption of nutrients as your food is broken down by active, friendly bacteria. Extreme Health Probiotics supports the healthy proliferation of more friendly bacteria in the colon. This final step helps improve overall immunity by preventing "bad" bacteria from flourishing, enabling your bodies natural process for fighting infection. In addition, Extreme Health USA ProBiotics 120 Billion is a dairy-free formula is suitable for even the most sensitive digestive systems since it contains no soy, yeast, wheat or lactose.
Extreme Health USA ProBiotics 120 Billion Highlights:
Probiotic bacteria favorably alter the intestinal microflora balance, inhibit the growth of harmful bacteria, promote good digestion, boost immune function, and increase resistance to infection. People with flourishing intestinal colonies of beneficial bacteria are better equipped to fight the growth of disease-causing bacteria. Lactobacilli and bifidobacteria maintain a healthy balance of intestinal flora by producing organic compounds—such as lactic acid, hydrogen peroxide, and acetic acid—that increase the acidity of the intestine and inhibit the reproduction of many harmful bacteria. Probiotic bacteria also produce substances called bacteriocins, which act as natural antibiotics to kill undesirable microorganisms.
Where are they found?
Beneficial bacteria present in fermented dairy foods—namely live culture yogurt—have been used as a folk remedy for hundreds, if not thousands, of years. Yogurt is the traditional source of beneficial bacteria. However, different brands of yogurt can vary greatly in their bacteria strain and potency. Some (particularly frozen) yogurts do not contain any live bacteria. Supplements in powder, liquid extract, capsule, or tablet form containing beneficial bacteria are other sources of probiotics.
About Extreme Health USA
Extreme Health USA's mission is to provide the best in superfoods and natural dietary supplements that help support consumer's health and wellbeing. Consumers who are passionate about their health and are looking for cutting edge products that go beyond mainstream health foods choose their products for their superior quality.
Extreme Health USA's certified organic products are carefully sourced through partnerships with local farmers around the world. They take all precautions needed to preserve nutrient content with minimal processing so that they deliver products with maximum health value. Their natural supplements are produced in a facility that is GMP certified and complying with the highest in manufacturing standards. That's why physicians and other health care practitioners have sold their product line to their patients for over ten years.
But health is not just an individual state of being. Extreme Health USA is committed to protecting the world we all live in. The products they offer are harvested or farmed in an environmentally friendly way without pesticides, and wild crafted ingredients are picked in native forests.
Extreme Health USA is also committed to supporting indigenous farmers wherever they source products through fair trade practices.
This is a 2 month supply.
Mix 1/4 teaspoon per day with water and take with a small amount of food 2 hours before or after your meal or after taking medications, especially antibiotics. You may increase dosage when instructed by your health care professional. Regular use is recommended to support a healthy digestive and immune system.
Keep out of reach of children.
Keep refrigerated after opening.
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The U.S. Coast Guard is facing the dilemma of its traditional threats combining to pose a synergistic danger to U.S. homeland security. Longtime menaces such as drug smuggling, alien immigration and terrorism may be merging their organizations and their tactics to pose an even greater threat to the nation. Stopping these threats will require data sharing and consolidation. Unfortunately, even organizations willing to share information often find legal and technological roadblocks in their way. Rear Adm. (S) Stephen Metruck, USCG, chief of staff, Eleventh Coast Guard District, told the Thursday breakfast audience at West 2011 in San Diego that the Coast Guard is striving to head off threats before they near the homeland. "Goal defense" is not an effective way of stopping adversaries, he explained. The Coast Guard is working to develop new methods of detecting and identifying threats before the marauders launch their plans into action. Operation Focused Lens, for example, looks at places from where attacks may come. The goal is to detect anomalous activity before a smuggling or terrorist boat is launched. Marina operators would be engaged through an outreach program to report suspicious signs such as boaters practicing illegal activities. Combining data may be harder. Adm. Metruck allowed that many firewalls prevent government agencies from linking their databases, even within the Department of Homeland Security. In some cases, the only solution is to place people from different agencies side-by-side so that they can share views on their computer displays.
The U.S. Navy has killed some programs and accelerated others as it restructures its budget priorities. Robert O. Work, undersecretary of the Navy, gave the West 2011 Wednesday luncheon audience a bluntly candid assessment of which systems worked, which didn't and were canceled, and which are on probation. One of the key systems killed was the Marine Corps Expeditionary Fighting Vehicle. While it had a troubled history, it was going well recently, but the Navy-acting on a recommendation from the commandant-killed the program because it was going to eat up too much of the Corps' budget in the future. Work reported that it would have consumed 50 percent of all Marine Corps procurement funds-100 percent of Marine Corps historical vehicle expenditures-between 2018 and 2025. Work was much harsher in his explanation of why the Navy canceled the ALQ-99 jamming pod for the EA-18G Growler aircraft. "The Growler is a good aircraft, but the ALQ-99 is a piece of crap-the polite thing to say is that it's reaching the end of its service life," Work declared to an attentive audience. "Instead, we'll have something better for the Growler." The F-35B short takeoff vertical landing aircraft program is having problems, and it has been put off two years so that its problems can be fixed. Work expressed confidence in that decision, saying, "We are absolutely convinced that we will fix the problems in the F-35B." But Work waxed eloquent about the Littoral Combat Ship (LCS) program, which is proceeding with two vastly different production designs. Calling it "one of the most misunderstood ships in the Navy," he nonetheless praised both its capabilities and its program structure. Having two companies concurrently producing LCS ships at the current schedule has saved the taxpayer $2.9 billion, Work stated. Three missions that used to require different classes of ships have been combined into one, and he is confident it will work well.
The U.S. Navy is re-tailoring its force as it realizes efficiencies driven by budgetary needs, according to the undersecretary of the Navy. Robert O. Work enthusiastically told the audience at Wednesday's West 2011 luncheon that the new budget direction is giving the Navy opportunities to build the type of force that it needs for the coming decades. "Our shipbuilding program is more stable than it has been in a decade," Work declared. Work described how many budget savings have been re-allocated to other programs, which is providing long-term savings through accelerated development. Some of the programs that were cut were doing well, but they fell into the category of "exquisite capabilities"-highly desirable, but not absolutely necessary. The savings were redirected toward programs that were essential to the Navy's future. "We accelerated things that we knew we needed," he related. The Navy will "buy smarter," acquiring exactly the same as it bought last year, but for $8.5 billion less, he continued. However, he admits that what keeps him up at night is the continuing resolution under which the Navy is operating now. The Navy is capped at 2010 levels and cannot begin new programs. "We've got to get that fixed," Work charged, "or it will force the Department of the Navy to make stupid and irrevocable decisions."
The dynamic modernization of China's economy and society may owe more to momentum than careful planning. Dr. Xinjun Zhang, associate professor of public international law, Tsinghua University, Beijing, offered that he believes that China does not have a vision guiding the massive changes that define China today. Zhang offered that China's current policies have emerged from Deng Xiaoping's approaches, which he implied were a bit too pragmatic. Speaking at a policy panel that included former U.S. Pacific Command head Adm. Timothy J. Keating, USN (Ret), and moderated by former Good Morning America host David Hartman, Zhang said a lack of vision has plagued much of Chinese policy. This extended to the lack of progress on reunifying Taiwan with the mainland. While not claiming to be a Maoist, Zhang did praise People's Republic of China founder Mao Zedong for his vision. Zhang even said that if Mao were to return, he would come up with a solution for reunification. Zhang warned against pressuring China on human rights and other internal policies. China has "a very complicated government," he said, as it tries to run a diverse country rife with different ethnic groups and languages. Maintaining stability is important both to China and to the rest of the world. "I cannot imagine the consequence to the globe without a stable ruling government in China," Zhang declared.
China and the United States are plagued by a "strategic mistrust" that hinders relations between the two. That statement was made by Adm. Timothy J. Keating, USN (Ret.), former commander of the U.S. Pacific Command, in a panel discussion with Dr. Xinjun Zhang, associate professor of public international law, Tsinghua University, Beijing, that was moderated by former Good Morning America host David Hartman. To the audience, that strategic mistrust was evident in the exchange of comments between Zhang and Adm. Keating throughout the panel. Both expressed their country's points of view in direct opposition to each other's. Despite an amicable atmosphere, the two men expressed diametrically opposed views even when they shared the same policy goals. Adm. Keating called for greater understanding through transparency and communication, while Zhang said that China feels threatened by U.S. surveillance ships and aircraft at the edge of its territory. Perhaps issues with North Korea personified the differences best. Both men agreed that their countries' policies aimed at having a non-nuclear Korean peninsula, and both agreed that removing nuclear weapons development from North Korea was essential. However, Adm. Keating emphasized the urgency of quick action before North Korea developed an effective nuclear arsenal, while Zhang called for patience to maintain stability while all sides worked toward the same goal.
The battlespace dominance enjoyed by U.S. forces for two decades may be disappearing as many potential adversaries begin to employ the very technologies that have served U.S. forces. Dick Diamond Jr., national security trends and strategic issues analyst with Raytheon Integrated Defense Systems, warned that the near monopoly enjoyed by the United States in precision guided munitions (PGMs) and surveillance is going away. "We may not be able to conduct our favorite American way of war in the future," Diamond declared. Moderating a West 2011 panel focusing on unmanned systems, Diamond went on to say that the United States may not be able to position forces forward for fighting at a time of its choosing. These forces would be vulnerable to other countries that are procuring PGMs at affordable prices. As a result, maritime forces will need to be positioned farther away from shore. And, information dominance may be the key battlefield of the future. "Just ask the Iranian nuclear engineers," Diamond offered.
The U.S. Marine Corps will need to innovate while maintaining its traditional amphibious capabilities as nations act more in their own interests, suggests a Marine Expeditionary Force (MEF) deputy commander. Maj. Gen. Melvin G. Spiese, USMC, deputy commanding general, 1 MEF, told a West 2011 luncheon audience that the Corps is exploring innovative solutions to meet new international contingencies. "The U.S. Marine Corps has never met the nation's needs by being conventional in its approach," the general declared. Gen. Spiese emphasized that Marine Corps capabilities hinge on its being able to interoperate with the U.S. Navy. Among those capabilities is amphibious assault, which-as opposed to many new doctrines-remains relevant and important. The general stated that most nations, including friends, act in their own interests. As a result, it is harder to arrange for allies to go along with U.S. policies. Nations change their policies over time as their national interests change. The United States cannot assume these nations will support it as a matter of fact, Gen. Spiese stated. So, the United States should not place itself in a position where pursuing its interests rely on the policies of another nation.
The U.S. Navy may have gone too far in emphasizing defensive measures over offensive capabilities, which it may need to rectify quickly. Vice Adm. Richard W. Hunt, USN, commander, U.S. Third Fleet, told the Kickoff Address audience at West 2011 that the recent emphasis on missile defense and cyberspace security may have overlooked the need to maintain leading-edge offensive capabilities in related areas. "We've stepped away and become too defensive," the admiral declared. The Navy needs to develop offensive capabilities to take the fight to the adversary instead of merely being reactive, he continued. Protecting the fleet is necessary, but the sea service must not neglect its strike mission. In particular, while citing the importance of cybersecurity, the admiral called for an offensive cyberspace capability-"look at it from a warfighter perspective," he said.
Maintaining maritime security will require humanitarian activities as well as traditional gunboat diplomacy, according to a U.S. Navy fleet commander. Vice Adm. Richard W. Hunt, USN, commander, U.S. Third Fleet, told the Kickoff Address audience at West 2011 that being able to provide disaster response and humanitarian assistance will be vital for ensuring maritime security. Many nations "could go either way" in either supporting or opposing U.S. national interests, the admiral explained. If the United States can respond rapidly and effectively when one of those nations suffers a natural disaster, that action could be the tipping agent that swings the nation into the U.S. column, he said. "It's not just kinetic power ... we must be a global force for good," Adm. Hunt declared.
The key to providing greatly enhanced cyber security may be at hand, but it may also eliminate one of the Internet's greatest characteristics, and a middle ground may be hard to achieve. Carter Bullard, president and chief executive officer, QoSient, told the audience at a MILCOM 2010 Wednesday afternoon panel on cyber security that technologies are needed for three elements-attribution, mitigation and deterrence. Attaining attribution and mitigation will lead to deterrence, he maintained. A key means of attribution is non-repudiation, which he described as having the potential to go after the entire threat matrix. This discipline would provide comprehensive accountability that prevents any interloper from concealing that they attacked, thus creating the concept that a hacker can get caught. Bullard bemoaned the fact that no one is building technology for non-repudiation, calling it "the most misunderstood countermeasure." However, one of his fellow panelists raised an alarm about its incorporation. Elliot Proebstel, on the technical staff of Sandia National Laboratories, warned that building in non-repudiation might threaten valued Internet freedoms. The existing anonymity that every Internet user takes for granted might disappear as every user could be identified. This would be a boon to dictatorships that seek to identify and stifle Internet users opposed to their regimes, he offered.


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AUSTINTOWN, Ohio - It's a challenge facing more than five million American families. By mid century, it's estimated the number of people living with Alzheimer's could triple, forcing even more people into the role of caregiver."You have to have confidence to care for somebody with Alzheimer's, you know, and that is a daily tip we give our caregivers, too. You have to display confidence in your actions because if you don't then people don't trust you when you are taking care of them," said Dottie Johntony with Home Instead Senior Care in Austintown.Johntony says its easy for caregivers to become overwhelmed and frustrated. In fact, according to the Alzheimer's Association, 60 percent of Alzheimer's and Dementia Caregivers rate the emotional stress of their job as high or very high. "Unfortunately, the part of care giving that nobody truly sees is the side where you are not getting the care you need for yourself because you can't care for somebody else if you aren't taking care of the needs for yourself, too," said Johntony.To help prevent caregivers from becoming overwhelmed, Home Instead has created a free app, available only for Apple products, that families can use to search behaviors and find solutions to problems.
It's also designed to help families manage the stress so they can maintain the confidence they need to care.In honor of World Alzheimer's Month, Home Instead Senior Care is also offering free booklets with tips and resources to families and caregivers.
You can call their office at 330-729-1233 for a copy.
Those same booklets will also be given out on Tuesday, September 24 at the 'Confidence to Care' family workshop, which is a free program for caregivers.
It will take place at Home Instead Senior Care, 45 N. Canfield Niles Road in Austintown.
To register, call 330-729-1233.


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The sporting programme has been decided. The 2012 European Football Championship will take place with the strongest field of participants since its inauguration in 1960. The Czech Republic, Ireland, Portugal and Croatia qualified from the play-off encounters on November 11 and 15, thus completing the field of 16 national teams which will fight for the European title from June 8. All countries that have won the European championship during the past 51 years have qualified for the major tournament to be held in Poland and the Ukraine, under the direction of the European Football Association, UEFA.
An inside view of the new, 500 million Euro Olympic Stadium in Kiev, where the final of the UEFA EURO 2012 will take place on July 1. (Photo: GES/Augenklick)
The draw for the four final round groups of UEFA EURO 2012 on December 2 will be a further milestone for the top level competition. The venue is Kiev, where the final will take place on July 1. At 18:00 hrs local time (17:00 hrs Central European Time) the 16 teams will be drawn into four groups of four teams each at the Arts Palace in the Ukrainian capital. As usual at European Championships and World Cups, there will be an allocation of the teams.
They will be distributed between four drawing pots with two different aspects considered. The host teams of UEFA EURO 2012 should – as previously practised at the European Championship finals in the Netherlands and Belgium – play their matches in their own countries as far as possible.
Therefore Poland and the Ukraine have gone into pot 1, together with reigning European champions Spain and World Cup runners-up Netherlands. Those two teams have currently the best records within UEFA. Germany, as World Cup bronze medallists and European runners-up, are in third place just behind the Netherlands and are in pot 2 with Italy, England and Russia.
Slavek and Slavko are the mascots for the 2012 UEFA European Championship. They succeed Trix and Flix, the mascots in Switzerland and Austria. (Photo: Firo/Augenklick)
The pots look like this (the former titles of the respective teams in brackets):
Pot 1: Spain (champions 1964 and 2008), Netherlands (1988), Poland, Ukraine
Top venues for UEFA EURO 2012
In the first leg of three of the four play-off encounters a winning margin was achieved. Croatia defeated Turkey 3-0 away so the goalless draw in the second leg in Zagreb was sufficient for qualification. That meant the end of the road for Guus Hiddink, Turkey's national coach. The Turkish Football Association sacked the Dutchman, who had failed to qualify for the World Cup finals two years ago with Russia. Hiddink had been much more successful in earlier years as national coach of Australia, South Korea and the Netherlands. He also had attracted much attention with Russia at UEFA EURO 2008 in Switzerland and Austria.
A view over the old town of Warsaw. The new National Stadium is located behind the bridge with its harp over the Wisla River. (Photo: Firo/Augenklick)
Another very experienced coach won through to the European Championship finals. Italian Giovanni Trapattoni led Ireland to UEFA EURO 2012. After the 4-0 win in Estonia the 1-1 draw in Dublin was sufficient for the Irish to reach the finals for the first time in 24 years. The Czech Republic were the only team to achieve two wins in the play-offs. They defeated Montenegro 2-0 at home and 1-0 away. The fans in Lisbon experienced a frantic goalfest, when Portugal thrashed Bosnia-Herzegovina 6-2 after a goalless draw in the first leg to belatedly qualify for the finals with the 16 best European teams.
Preparations in the host countries are almost complete. The refurbished stadium in Poznan was opened last year. The arena in Gdansk followed in September 2011, and the stadium in Wroclaw on November 11. The National Stadium in Warsaw, hosting the opening match of UEFA EURO 2012, should be finished in December 2011.
The stadium in Lviv (Lvov) was the fourth and last venue in the Ukraine to be inaugurated with the international match between the Ukraine and Austria (2-1) in mid-November. Four days previously the new Olympic Stadium in Kiev hosted its first major football match when the Ukraine drew 3-3 with Germany. The Metalist Stadium in Charkiv (Charkov) and the state-of-the-art Donbass Arena in Donetsk were unveiled in 2009. After overcoming a few problems, all venues are in top shape six months prior to the kick-off of UEFA EURO 2012. The decision on which teams will play in the various stadiums in the group matches will be taken on December 2.


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Part II is going to be a bit shorter than part I as I still have not been able to make it through all of the shots from the game on 6/26. I think I took like 750 pictures that day, so there are a lot to go through.
Anyway today we will pick up where we left off in the last thread, with Chipper's go ahead 3 run home run off a Joel Zumaya (poor guy broke his elbow this week) 100 MPH fastball to give the Braves the lead. I didn't get a good shot of the home run swing, but I got what happened next.
Gregor Blanco heads for home as he applauds Chipper's homer
Melky Cabrera also scores on the Chipper HR
Brian Snitker congratulates Chipper during his trot
Chipper feeling the love
Top of the next inning Chipper takes the field by himself and sports a smile when he realizes what his teammates have done. Chills went down my spine as everyone stood up and gave him a rousing ovation
Chipper was a bit embarrassed by what his teammates had done
But he still tipped his cap to the fans for the ovation
Jonny Venters came on next to pitch
Yunel makes the throw to first on a slow hopper to short
Jair Jurrjens hanging out on the top step of the dugout
Troy Glaus (Glausosaur) getting into the hit column
Eric Hinske promptly smacks a double to Right Center
Glaus is waved in by Snitker and scores from first on the play
Jason Heyward (I actually got to see him in person) came in to pinch run for Hinske (Hey, there's nothing wrong with his legs!)
Jason Heyward sticks his tongue out at me as I snapped this shot of him (ok, it probably wasn't really at me, but it looks that way!)
Prado and Yunel have fun playing the game
Jason Heyward stays in the game as a defensive replacement
Miguel Cabrera got one back when he deposited this Saito pitch into the left field stands
Brandon Inge bat flex


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The Calgary Committee is dedicated to creating exceptional people-to-people opportunities for citizens, businesses and organizations in both communities. The Committee supports student exchanges and actively promotes business opportunities through the organization of trade missions and business forums. The Committee helps organize the Canada Week, and participates at the Great Canadian Picnic which attracts thousands of winter Canadians to the all day event. The Committee facilitates the participation of Calgary youth who have suffered burns by bringing them to Phoenix each year to attend Camp Courage, a local burn camp. The Calgary Committee meets on the third Monday of each month and welcomes new members.
Calgary Committee Contact Information
Next Meeting:
Monday, September 15, 2014
Monday, October 20, 2014
Monday, November 17, 2014
Dates and times are subject to change. Please confirm meeting dates, times and locations one week prior the scheduled dates above.
For older Meeting Agendas and Minutes click here.


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Support Groups
Bereavement/Grief Support Group. For anyone who has experienced the death of a loved one. Every other Mon., 6–8 p.m. Every other Wed., 10–11:30 a.m. Central Vermont Home Health & Hospice (CVHHH), 600 Granger Rd., Berlin. Ginny or Jean 223-1878.
Bereaved Parents Support Group. Facilitated by CVHHH. Second Wed., 6–8 p.m. CVHHH, 600 Granger Rd., Berlin. Jeneane Lunn 793-2376.
Living with Advanced or Metastatic Cancer. Lunch provided. Cancer Center resource room, Central Vermont Medical Center. Call for meeting times: 225-5449.
Cancer Support Group. First Wed., 6 p.m. Potluck. For location, call Carole Mac-Intyre 229-5931.
Man-to-Man Prostate Cancer Support Group. Third Wed., 6–8 p.m. Conference room 2, Central Vermont Medical Center. 872-6308 or 866-466-0626 (press 3).
Hurricane Irene Support Group for Recovery Workers. Get peer support and help processing emotions, strengthen relationships and learn coping skills. Every other Mon., 3:30 p.m. Unitarian Church, 130 Main St., Montpelier. 279-4670.
Hurricane Irene Support Group. Share your story, listen to others, learn coping skills, build community and support your neighbors. Refreshments provided. Wed., 5:30 p.m. Berlin Elementary School. 279-8246.
Brain Injury Support Groups. Open to all survivors, caregivers and adult family members. Evening group facilitated by Marsha Bancroft; day group facilitated by Kathy Grange and Jane Hulstrunk. Evening group meets first Mon., 5:30–7:30 p.m. DisAbility Rights of Vermont, 141 Main St., Suite 7, Montpelier, 800-834-7890, x 106. Day group meets first and third Thurs., 1:30–2:30 p.m. Unitarian Church, 130 Main St., Montpelier. 244-6850.
NAMI Vermont Family Support Group. Support group for families and friends of individuals living with mental illness. Fourth Mon., 7 p.m. Central Vermont Medical Center, room 3, Berlin. 800-639-6480 or namivt.org.
Celiac and Food Allergy Support Group. With Lisa Masé of Harmonized Cookery. Second Wed., 4:30–6 p.m. Conference room 3, Central Vermont Medical Center. email@example.com.
Diabetes Discussion Group. Focus on self-management. Open to anyone with diabetes and their families. Third Thurs., 1:30 p.m. The Health Center, Plainfield. Free. Don 322-6600 or email@example.com.
Diabetes Support Group. First Thurs., 7–8 p.m. Conference room 3, Central Vermont Medical Center. 371-4152.
Grandparents Raising Their Children's Children. First Wed., 10 a.m.–noon. Barre Presbyterian Church, Summer St. Second Tues., 6–8 p.m. Wesley Methodist Church, Main St., Waterbury. Third Thurs., 6–8 p.m. Trinity United Methodist Church, 137 Main St. Child care provided in Montpelier and Waterbury. Evelyn 476-1480.
Overeaters Anonymous. Twelve-step program for physically, emotionally and spiritually overcoming overeating. Fri., noon–1 p.m. Bethany Church, 115 Main St., Montpelier. 223-3079.
Sex Addicts Anonymous. Mon., 6:30 p.m. Bethany Church, 115 Main St., Montpelier. Call 552-3483 for more information or to leave a confidential message.
Turning Point Center. Safe, supportive place for individuals and their families in or seeking recovery. Open daily, 10 a.m.–5 p.m. 489 North Main St., Barre. 479-7373.
Sun.: Alchoholics Anonymous. 8:30 a.m.
Tues.: Making Recovery Easier workshops. 6–7:30 p.m.
Wed.: Wit's End Parent Support Group. 6 p.m.
Thurs.: Narcotics Anonymous. 6:30 p.m.
Women's Group. Women age 40 and older explore important issues and challenges in their lives in a warm and supportive environment. Faciliatated by Amy Emler-Shaffer and Julia W. Gresser. Wed. evenings. 41 Elm St., Montpelier. Call Julia, 262-6110, for more information.
Men's Group. Men discuss challenges of and insights about being male. Wed., 6:15–8:15 p.m. 174 Elm St., Montpelier. Interview required: contact Neil 223-3753.
National Federation of the Blind, Montpelier Chapter. First Sat. Lane Shops community room, 1 Mechanic St., Montpelier. 229-0093.
Families of Color. Open to all. Play, eat and discuss issues of adoption, race and multiculturalism. Bring snacks and games to share; dress for the weather. Third Sun., 3–5 p.m. Unitarian Church, 130 Main St., Montpelier. Alyson 439-6096 or firstname.lastname@example.com.


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Don DodgeTag
Don Dodge, A Must Have Speaker At Every Startup Conference
Don Dodge is a must have speaker at every startup conference, period. Don addresses the topic 'Failure'. Failure is not only the biggest reality..
Startup Articles, Advice And Readings For The Week
- What Startups Are Really Like-Paul Graham
- Wannabe Entrepreneur Symptoms and Cures-Gabriel Weinberg
- The Funnel Principle: Software &..
Don Dodge: 5 Important Things For Entrepreneurs
Don Dodge is a veteran of five start-ups including Forte Software, AltaVista, Napster, Bowstreet, and Groove Networks. Don was recently Director..


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February 6, 2014
Miami Heat guard Dwayne Wade (3) is defended by Los Angeles Clippers forward Blake Griffin (32) at Staples Center. (USA TODAY Sports: Kirby Lee)
Stories this photo appears in:
Limited playing time helps injury-hit Wade flourish for Heat
Ongoing knee injuries have been a source of frustration for Miami Heat guard Dwyane Wade in recent years but a meticulous program of limiting his workload and playing time has made him an influential force this season.
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