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104 Cards in this Set
- Front
- Back
Whole mount section of pituitary gland. The anterior lobe comprises 80% of the pituitary gland.
Top: Routine H & E stained section of anterior pituitary. On H & E staining, three types of cells can be identified in the anterior pituitary: acidophils, basophils and chromophobes.
Bottom: Immunostain for growth hormone. Immunostaining can enable one to determine which hormones are being produced by a population of cells.
MRI of the head revealing a pituitary macroadenoma (white arrow). MRI is the preferred imaging technique for diagnosing pituitary adenomas.
Sagittal section of brain from a patient who died with a pituitary macroadenoma (white arrow). This macroadenoma was in all likelihood nonfunctioning, and probably came to clinical attention due to mass effects. Nonfunctioning adenomas can often compress and destroy the surrounding normal pituitary parenchyma resulting in hypopituitarism. In addition, some macroadenomas can compress the pituitary stalk (yellow arrow) impeding the delivery of dopamine from the hypothalamus to the anterior pituitary. This will free up the lactotrophs from dopaminergic inhibition resulting in increased release of prolactin from the anterior pituitary and hyperprolactinemia. This sequence of events is referred to as the "stalk effect." -- will be on test!!!!
Left: Normal pituitary H&E stain. There are cells of different types, which are divided into discrete lobules by delicate fibroconnective tissue trabeculae.
Right: Normal pituitary reticulin stain. This reticulin stain highlights the delicate connective tissue fibers (reticulin network) that divide the endocrine cells in the anterior pituitary into discrete lobules.
Left: Pituitary adenoma H&E stain. Adenomas exhibit a monotonously uniform (monomorphic) population of cells. The cells are arranged in solid sheets and are not divided into discrete lobules by fibroconnective tissue trabeculae.
Right: Pituitary adenoma reticulin stain. There is a solid sheet of cells without any reticulin network
Transsphenoidal surgery: Roof of the mouth- sphenoid sinus – pituitary gland
acromegaly- identical twins
Left: H&E stained section of a typical somatotroph adenoma composed of acidophilic cells.
Right: Immunostain performed on a somatotroph adenoma, which is strongly positive for growth hormone.
Left: Histologic section of a craniopharyngioma exhibiting squamous and columnar epithelium.
Right: Histologic section of a craniopharyngioma exhibiting glandular spaces containing eosinophilic proteinaceous material. The yellow arrow is pointing at a focus of calcification. Craniopharyngiomas are benign tumors with an excellent prognosis; however, because of their critical anatomic location, they can cause significant problems due to local mass effects.
Histologic section of normal thyroid gland exhibiting multiple follicles lined by follicular epithelium containing colloid. The colloid is rich in thyroglobulin. Less active- tend to be flat, more active- follicular epithelium cells tend to be more columnar.
Section of thyroid gland showing C Cells having clear cytoplasm surrounding a few follicles. Secretes calcitonin- decreases Calcium level.
Immunohistochemical stain of thyroid tissue for calcitonin. The brown precipitates represent C cells containing calcitonin.
Left: Low power view of thyroid gland involved in Hashimoto Thyroiditis. There are numerous lymphoid follicles w/ reactive germinal centers.
RIght: High power view of thyroid gland involved in Hashimoto Thyroiditis. There is Hurthle cell metaplasia with infiltrates of lymphocytes and plasma cells.
In the later stages of Hashimoto thyroiditis, much of the thyroid parenchyma becomes replaced by fibrous tissue.
Individuals w/ Hashimoto thyroiditis are at increased risk for developing other AI diseases, both endocrine (type 1 diabetes, AI adrenalitis) and non-endocrine (SLE, Myasthenia gravis, Sjogren's). they are also at inc risk for the development of B cell non-hodgkin lymphomas, esp marginal zone lymphomas of mucosa associated lymphoid tissues (MALT lymphomas)
Examples of ophthalmopathy seen w/ Graves disease.
Histologic sections of thyroid from pts w/ Graves dz
Left: Papillary hyperplasia
right: scalloping
Histologic sections of a multinodular goiter
Left: Gross photo of an adenoma of the thyroid gland
Right: histologic section of an adenoma forming many small follicles (microfollicular adenoma)
Histologic sections of thyroid papillary carcinoma.
Left: typical example of a papillary carcinoma exhibiting numerous papillary fronds
upper right: section of a papillar carcinoma exhibiting ground-glass "orphan annie eye" nuclei
Lower right: section of a papillar carcinoma exhibiting psammoma bodies (blue arrow)
Upper left: follicular carcinoma forming numerous small follicles.
Lower left: Follicular carcinoma exhibiting a nest of tumor cells w/n a large vessel contiguous to the tumor capsule (blue arrow), indicative of vascular invasion.
Right: Follicular carcinoma invading completely through the capsule into surrounding thyroid tissue. The yellow arrow is pointing at the tumor capsule and the blue arrow is pointing at tumor which has invaded out into surrounding thyroid parenchyma. Since the tumor has penetrated through the capsule and is invading into surrounding thyroid tissue, this woudl already be considered to be a widely invasive follicular carcinoma.
Left: Medullar carcinoma. The tumor cells are relatively small and uniform, which is typical for a neuroendocrine type of tumor, and are arranged largely into nests and trabeculae (cords). A few small follicular-like structures are identified; however, no colloid is present in these follicular-like structures. Much of the pink material in the stroma is amyloid, which gets deposited because these tumors produce peptide hormones, esp calcitonin.
Right: Immunostain of a medullary carcinoma for calcitonin, which is strongly positive.
Histologic sections of normal parathyroid glands. Fat tissue typically comprises up to 30% of the parathyroid glands.
Left: Low power view of a parathyroid adenoma
Right: High power view of a parathyroid adenoma. Note the high degree of cellularity w/n the adenoma, as well as the absence of any intervening adipose tissue.
section of bone from a pt w/ primary hyperparathyroidism exhibiting osteoclasts actively engaged in bone resorption boring through a trabecula of bone. This is referred to as "dissecting osteitis".
Left: Gross photo of the hands of a pt w/ PHP type 1A (albright hereditary osteodystrophy). Note that the 4th finger is shorter than normal, being only slightly longer than the fifth.
Right: X-ray of the pts right hand. Note that the 4th metacarpal is shorter than the metacarpal bones of the other fingers, resulting in shortening of the 4th finger.
Left: gross photo of a pheochromocytoma arising from the adrenal medulla
Upper right: Histologic section of a pheochromocytoma. the tumor cells are large and have abundant eosinophilic cytoplasm, in contrast to the normal adrenocortical cells having clear cytoplasm on the far right side of the field.
Lower Right: Histologic section of a pheochromocytoma exhibiting the classic "Zellballen" growth pattern, which is most characteristic of pheochromocytomas. In the "zellballen" growth pattern, the tumor cells are arranged into rounded nests surrounded by delicate fibrovascular tissue trabeculae.
unfortunately, the biologic behavior of a pheochromocytoma cannot be accurately assessed based solely upon he histologic features; so that the diagnosis of malignancy in pheochromocytomas is based exclusively on the presence of metastases.
Gross photo from an autopsy revealing markedly hemorrhagic adrenal glands (white arrows).
Right: Histologic section of adrenal cortex exhibiting hemorrhage.
--- waterhouse- Friderichsen syndrome
Nodular Glomerulosclerosis (Kimmelstiel-Wilson disease) as seen on a routine H&E stain. The arrow is pointing to a nodule, which is composed of mesangial matrix.
Histologic section of retina from a case of diabetic retinopathy, after trypsin digestion to remove surrounding connective tissue, illustrating capillary microaneurysms.
histologic section of an insulinoma: round oval & dark staining
Patient with a glucagonoma exhibiting necrolytic migratory erythema.
Woman exhibiting a large multinodular goiter. Multinodular goiters can get to be quite large (up to 100x normal wt.). In addition to being a cosmetic problem, large multinodular goiters can cause problems due to mass effects, with compression of the larynx & trachea causing airway obstruction and compression of the esophagus causing dysphagia (difficulty swallowing). Goiters are the result of impaired thyroid hormone synthesis, which results in increased release of TSH from the pituitary gland. In addition to stimulating increased secretion of T3 & T4 from the thyroid gland, TSH also acts as a growth factor and causes the thyroid follicular cells to undergo hyperplasia and hypertrophy. Most patients with a goiter are euthyroid (i.e. their T3 & T4 levels are normal), but at the cost of an increased TSH level.
Gross photograph of a multinodular goiter. Note the presence of multiple nodules of varying size interspersed throughout the thyroid gland. Darker areas (white arrow) are due to the presence of hemorrhage, and lighter areas (yellow arrow) are due to the presence of fibrosis. The nodules that develop in a multinodular goiter are probably due in part to the fact that some follicular cells are inherently more responsive to TSH than others. In addition, over time somatic mutations develop in some of the follicular cells that gives them a growth advantage. Indeed, both monoclonal & polyclonal nodules coexist within a multinodular goiter.
Histologic section of a multinodular goiter. This section shows three nodules of varying size. There are scattered areas of hemorrhage (a light blue arrow is pointing to one of these). There are also a few areas exhibiting fibrosis (a red circle is present in one of these areas). The regressive changes present in multinodular goiters (i.e. areas of hemorrhage, fibrosis, calcification & cystic change) are felt to be related to the uneven asymmetric growth that occurs in multinodular goiters, which produces stresses in the gland resulting in rupture of blood vessels & dilated follicles.
MRI of a pituitary adenoma after administration of contrast media. The yellow arrow is pointing to a large pituitary adenoma. MRI, especially after administration of contrast media, is the best imaging technique to confirm a diagnosis of pituitary adenoma. Note the sharp border between the adenoma and surrounding brain. Pituitary adenomas being benign tumors most commonly exhibit expansile but not infiltrative growth.
However, in as many as 30% of cases, pituitary adenomas are not grossly encapsulated and infiltrate neighboring tissues, such as the cavernous and sphenoid sinuses, dura, and on occasion, the brain itself. Such lesions are termed invasive adenomas. Not unexpectedly, macroadenomas tend to be invasive more frequently than smaller tumors.
Some features associated with aggressive behavior by pituitary adenomas, include: increased mitotic activity, > 3% of the tumor cells staining positive for the proliferation marker Ki-67, overexpression of cyclin D1, p53 mutations, and epigenetic silencing of RB1. It is recommended that adenomas with these features be classified as atypical adenomas, since these tumors have a higher propensity for aggressive behavior, including invasion and recurrence. HRAS mutations are observed in the rarely occurring pituitary carcinomas.
Sagittal section of brain exhibiting a large pituitary adenoma (yellow arrow). Pituitary adenomas such as this, which are larger than 1cm in diameter, are referred to as macroadenomas. Macroadenomas are often nonfunctioning and most commonly cause symptoms due to local mass effects, including: visual field defects due to compression of the optic chiasm and headache, nausea & vomiting, and papilledema due to increased intracranial pressure. Light blue arrow is pointing to the pituitary stalk. Macroadenomas can also compress the pituitary stalk, thereby impeding the delivery of dopamine to the anterior pituitary resulting in hyperprolactinemia. This is referred to as the "stalk effect" (remember that dopamine inhibits the release of prolactin from the anterior pituitary).
Histologic section of normal anterior pituitary gland. The endocrine cells are divided into discrete lobules by thin fibroconnective tissue trabeculae (yellow oval is encircling one of these). There are three types of cells in the anterior pituitary when viewed with a routine H&E stain… basophils (yellow arrow), acidophils (white arrow) and chromophobes (blue arrow).
Histologic section of a prolactin secreting adenoma referred to as a "prolactinoma"or "lactotroph adenoma." Note that in this typical example of a pituitary adenoma, there is a solid sheet of cells, and the tumor cells are not divided into discrete lobules. All of the tumor cells look essentially the same, which is referred to as "monotonous uniformity" or "cellular monomorphism." All of the tumor cells in this field are chromophobes. Immunostains are required to determine which hormone(s) the tumor is producing.
Immunostain for prolactin, which is strongly positive, confirming the diagnosis of a prolactinoma. Prolactinomas are the most common pituitary adenomas, accounting for 30% of pituitary adenomas. Prolactinomas occur more commonly in women than men and the peak incidence is between 20-30 years of age. In young women, the most common symptoms of hyperprolactinemia are amenorrhea and galactorrhea. In men, the most common symptoms of hyperprolactinemia are decreased libido and impotence. Galactorrhea and gynecomastia can rarely also be seen in men.
Histologic section of the anterior pituitary involved by Lymphocytic Hypophysitis. The anterior pituitary is extensively infiltrated by lymphocytes and there is effacement of much of the parenchyma of the gland. Lymphocytic Hypophysitis is an autoimmune disorder of the anterior pituitary. It occurs most commonly in young women late in pregnancy or during the postpartum period. Lymphocytic Hypophysitis often results in hypopituitarism. Patients with this disorder may have autoimmune disorders in other endocrine glands, such as Hashimoto thyroiditis and autoimmune adrenalitis. Anti-pituitary antibodies are seen in 20% of these patients.
Aspergillus infection of the pituitary gland. Fungal and Mycobacterial infections can involve the pituitary gland resulting in hypopituitarism. Most of these infections are encountered in immunosuppressed individuals. The histologic section on the left is from the anterior pituitary. The area bounded by the yellow rectangle is extensively necrotic. Remnants of viable pituitary are seen above the yellow rectangle. The section on the right is from the necrotic area inside the yellow rectangle stained with a Gomorri Methenamine Silver (GMS) stain. The GMS stain reveals the presence of numerous fungal hyphae. Some of the hyphae exhibit acute angle branching (yellow arrow) typical of Aspergillus species.
Coronal section of brain revealing a Craniopharyngioma arising from the suprasellar region. Most craniopharyngiomas arise from the suprasellar region (i.e. the hypothalamic region), however, some of them can arise within the sella turcica (i.e. the intrasellar region). Most craniopharyngiomas are cystic and the tumor in this case exhibits multiple cystic spaces (yellow arrows are pointing to several of these). The blue arrow is pointing to the third ventricle, which is being compressed by the tumor. These tumors can cause symptoms due to local mass effects, such as visual field deficits. They can also cause symptoms due to deficiencies of pituitary hormones, including diabetes insipidus ( ADH secretion). A bimodal age distribution is observed, with one peak in childhood (5 to 15 years) and a second peak in adults 65 years or older.
Histologic section of a craniopharyngioma. Craniopharyngiomas are benign tumors derived from vestigial remnants of Rathke pouch. Rathke pouch is an extension from the developing oral cavity. In this typical example of a craniopharyngioma, one can appreciate columnar epithelium (yellow arrow), squamous-like epithelium (light blue arrow) and glandular structures containing eosinophilic proteinaceous material (red arrows). An area of calcification is present inside the yellow oval. Calcification is commonly present in craniopharyngiomas and often allows these tumors to be seen on routine skull x-rays.
Photograph of a patient with a thyroglossal duct cyst. Thyroglossal duct cysts are derived from remnants of the thyroglossal duct, which connects the base of the tongue to the thyroid gland during embryologic development. Thyroglossal duct cysts are one of the most common causes of a neck mass. They usually occur in the midline of the neck, and typically move upward on swallowing, since they are nearly always connected to the hyoid bone. Uninfected thyroglossal duct cysts are asymptomatic, however, infected thyroglossal duct cysts are often accompanied by pain and tenderness to palpation.
Histologic section of a thyroglossal duct cyst. The lumen of a thyroglossal duct cyst is lined by either respiratory (blue arrow) or squamous epithelium (red arrow). Thyroid tissue is present in the wall of a thyroglossal duct cyst in more than 60% of cases (tissue inside yellow oval). The thyroid tissue within the wall of a thyroglossal duct cyst can rarely give rise to a follicular adenoma or a carcinoma (usually a papillary carcinoma).
Histologic sections from a case of Hashimoto Thyroiditis. The low power image on the left reveals the presence of numerous lymphoid follicles with reactive germinal centers (yellow arrows point to several of these). The high power image on the right reveals numerous follicular epithelial cells exhibiting so-called "Hurthle cell metaplasia" (yellow arrow). Hurthle cells have abundant eosinophilic granular cytoplasm. Numerous mononuclear inflammatory cells are also noted (blue arrow). Hashimoto thyroiditis is an autoimmune disorder of the thyroid gland. These patients do not respond to anti-inflammatory drugs, and eventually develop hypothyroidism requiring thyroid hormone replacement therapy.
Histologic section from a patient with Subacute (Granulomatous) Thyroiditis. This entity is seen most often in women 30-50 years of age following a viral infection. The patients often present with a variety of constitutional symptoms, such as fever, malaise and myalgias, as well as pain in the neck that often radiates upward. They may have a transient period of hyperthyroidism related to disruption of follicles, followed by a transient period of hypothyroidism. The disease is self-limited and almost all of these patients regain normal thyroid function. This histologic section is typical of the active phase of the illness. There is a thyroid follicle (inside the blue oval) which has been disrupted by the inflammatory process. Residual colloid (white arrow) is present within the disrupted follicle and there are also numerous neutrophils (green arrow). Multiple multinucleated histiocytic giant cells (yellow arrows are pointing to some of these) are circumscribing the disrupted follicle.
Histologic section of thyroid gland from a patient with Graves Disease. Graves Disease is an autoimmune disorder of the thyroid gland in which the patients produce antibodies directed against the TSH receptor. In Graves Disease, the TSH receptor antibodies act as agonists and result in constitutive activation of the TSH receptors on the follicular epithelial cells. Constitutive activation of the TSH receptors results in hyperthyroidism, as well as hyperplasia and hypertrophy of the follicular epithelial cells. In this histologic section, there is formation of numerous papillae which project into the lumen of follicles. This change is caused by the increased number of cells lining the follicles, and is referred to as "papillary hyperplasia." Papillary hyperplasia occurs diffusely throughout the thyroid gland in Graves Disease. Also note the paucity of colloid within the follicles. In Graves Disease, the follicular epithelial cells are pinocytizing colloid and degrading thyroglobulin to release more T3 and T4, almost as fast as more colloid can be produced.
Thyroid gland exhibiting a follicular adenoma. Follicular adenomas are benign tumors derived from the follicular epithelial cells. There are a variety of different subtypes based upon the extent of follicle formation, size of the follicles, etc.. For example, there are macrofollicular adenomas (large follicles), microfollicular adenomas (small follicles), trabecular adenomas (cords of tumor cells with few follicles), etc.. The various subtypes of follicular adenomas are not important, since the different subtypes of follicular adenomas have no bearing on biologic behavior. They are benign and that's all the surgeon and the patient care about. In this typical example of a follicular adenoma, the tumor is well circumscribed, encapsulated (yellow arrow) and lighter in color than the surrounding normal thyroid gland. Most follicular adenomas are cold nodules on scintillation scans and are therefore commonly biopsied. The majority of follicular adenomas are 2-3cm in diameter at the time they are biopsied.
Histologic section of a Follicular Adenoma. The yellow arrow is pointing at the junction between the tumor and the capsule. Note how well this benign follicular neoplasm respects the capsule. Follicular adenomas never invade into the capsule.
Histologic section of a Follicular Carcinoma. Follicular carcinomas are malignant neoplasms derived from the follicular epithelial cells that typically form small follicles. Follicular carcinoma is the second most common type of thyroid cancer and is most commonly encountered in women 40-60 years of age. Follicular carcinomas similar to follicular adenomas are usually encapsulated. The yellow arrows are pointing to the overlying capsule. The tumor can be seen to be invading through the capsule into surrounding thyroid tissue (area inside white oval). Since the tumor invades completely through the capsule into the surrounding thyroid tissue, it would be considered to be a "widely invasive" follicular carcinoma. If the tumor invades into the capsule, but does not extend beyond the capsule, it is considered to be a "minimally invasive" follicular carcinoma. Minimally invasive follicular carcinomas have a 10-year survival rate similar to that for papillary carcinomas, whereas the 10-year survival rate for widely invasive follicular carcinomas is only 50%.
Histologic section of a Follicular Carcinoma, contiguous to the main tumor mass, exhibiting vascular invasion. The blue arrows are pointing to nests of tumor, which are within vascular spaces. The nests of tumor exhibit small follicles typical of a follicular carcinoma. Follicular carcinomas have a propensity to invade blood vessels and these tumors therefore often give rise to disseminated metastases. The preferred sites for metastases include: bone, lungs and liver. Because of their propensity for vascular invasion, follicular carcinomas overall have a worse prognosis than the more common papillary carcinomas.
Gross photograph of a Papillary Carcinoma of the Thyroid. Papillary carcinomas are malignant neoplasms, which are also derived from the follicular epithelial cells. It is the most common type of thyroid cancer and is most commonly encountered in women from 25 to 50 years of age. The vast majority of thyroid cancers related to previous exposure to ionizing radiation are of this type. The tumor in this example is largely unencapsulated with an irregular infiltrative margin. Most papillary carcinomas are unencapsulated. There is, however, an encapsulated variant comprising approximately 10% of these tumors. Note the "shaggy" or "ragged" appearance of the tumor on cut section, this appearance is due to the formation of numerous papillary fronds by the tumor.
Histologic section of a typical Papillary Carcinoma. There are numerous papillary fronds having fairly broad fibroconnective tissue cores.
Histologic section from a Papillary Carcinoma. No definite papillary fronds are evident in this section, however, there are a number of psammoma bodies (yellow arrows point to several of these). Psammoma bodies are laminated calcified concretions, which are a very characteristic feature of papillary carcinoma. Psammoma bodies are rarely if ever found in the other carcinomas arising in the thyroid gland, so when present they are virtually diagnostic of a papillary carcinoma.
High power view of a Papillary Carcinoma. Note the optically clear "ground glass" or "Orphan Annie eye"
nuclei (yellow arrow points to a good example of this). These nuclear features are characteristic of a papillary carcinoma. In fact, these nuclear features are more important in making the diagnosis of papillary carcinoma than are the architectural features. There is a variant of papillary carcinoma referred to as "follicular variant of papillary carcinoma," in which the tumor principally forms follicles similar to a follicular carcinoma. This variant, however, has the nuclear features of a papillary carcinoma with the optically clear nuclei, and indeed the biologic behavior is that of a typical papillary carcinoma. The black arrows are pointing to eosinophilic intranuclear inclusions, which are another feature of these tumors, albeit not as important as the optically clear nuclei. Papillary carcinomas have a propensity to invade lymphatics and often involve the cervical lymph nodes. Papillary carcinomas do not, however, usually exhibit vascular invasion, so that only 10-15% of patients with these tumors ever develop distant metastases. The prognosis for papillary carcinoma is therefore excellent with the overall 10-year survival rate being > 95%.
Gross photo of thyroid gland involved by a Medullary Carcinoma. In this typical example, the tumor is unencapsulated and has an irregular infiltrative border. Medullary carcinomas arise from C cells, which are neuroendocrine cells that normally secrete calcitonin. Medullary carcinomas can secrete other peptides as well, including: CEA, VIP, somatostatin and serotonin. Medullary carcinomas are familial in 30% of the cases. In the familial cases, the tumor is often multifocal and frequently involves both lobes. It is common practice to screen relatives of patients with medullary carcinoma with serum calcitonin levels or genetic testing for RET protooncogene mutations.
Histologic section of a Medullary Carcinoma. The tumor cells are polygonal to spindle-shaped, relatively small with hyperchromatic nuclei. The extracellular eosinophilic material represents deposition of amyloid (yellow arrows point to some examples of this). The amyloid deposition is a characteristic feature of this tumor and is due to the abundant production of calcitonin. Postoperatively, patients with medullary carcinoma are followed with serum calcitonin and CEA levels.
Photograph taken during surgery of a patient with a large Parathyroid Adenoma. Parathyroid adenomas are benign tumors which are often functional. The functional parathyroid adenomas autonomously secrete PTH resulting in hypercalcemia. Parathyroid adenomas can be in ectopic locations, such as higher up in the neck, within the substance of the thyroid gland or even within the mediastinum. This can make finding the adenoma at the time of surgery a challenge for the surgeon. The adenoma in this instance was readily apparent and easily accessible and this would have been an easy case for the surgeon, i.e. "Miller time!"
Histologic section of a Parathyroid Adenoma. The adenoma (area marked by the yellow oval) is very cellular with no intervening adipose tissue. The red arrow is pointing to the capsule of the adenoma. Outside of the capsule, there is a rim of surrounding normal parathyroid tissue with readily apparent intervening adipose tissue (yellow arrow).
X-ray of the hands from a patient with a parathyroid adenoma who developed osteitis fibrosa cystica. Osteitis fibrosa cystica is the name given to the skeletal changes that occur in patients with long-standing primary hyperparathyroidism. Note the radiolucent lytic areas in the distal phalanges (arrows point to good examples of this). PTH stimulates osteoclastic bone resorption, and patients with osteitis fibrosa cystica can develop pathologic fractures.
Gross photograph of an Adrenal Cortical Adenoma. Adrenocortical adenomas are usually yellow in color because of all the lipid in the tumor cells. They are well-circumscribed and are usually not larger than 2.5 cm in diameter. Most adrenocortical adenomas are actually nonfunctional (do not secrete any hormones). Nonfunctional adrenocortical adenomas are usually incidental findings during imaging studies or at autopsy. Functioning adrenocortical adenomas can produce cortisol (Cushing syndrome), aldosterone (Conn syndrome) or androgenic steroids (Adrenogenital syndromes).
Histologic section from an Adrenocortical Adenoma. The tumor cells look similar to those seen in the normal adrenal cortex. The tumor cells exhibit abundant foamy cytoplasm because of all the lipid they contain. The nuclei are for the most part small and uniform. Some mild nuclear enlargement and pleomorphism is often seen (arrows point to some examples of this). Functional and nonfunctional adenomas cannot be distinguished on the basis of their morphologic features. Determination of whether or not an adenoma is functional and what hormone is being produced is determined by the clinical presentation of the patient and laboratory measurement of hormone levels.
Gross photograph of an Adrenal Cortical Carcinoma. Adrenocortical carcinomas are usually large tumors often exceeding 20cm in diameter (such as this example). These tumors are often variegated (multicolored) because of areas of hemorrhage and necrosis. Adrenocortical carcinomas are more likely to be functional than the adenomas, and are therefore often associated with clinical manifestations of increased hormone secretion (hyperadrenalism).
Histologic sections from Adrenocortical Carcinomas. The section on the left reveals significant nuclear enlargement and pleomorphism. The tumor cells do not contain as much lipid as the cells in the adenomas. This may be do to the fact that the tumor cells in the carcinomas are often more actively secreting hormones resulting in some lipid depletion. The arrow on the left is pointing to an atypical mitotic figure (in this case a "tripolar" mitotic figure). Atypical mitotic figures are an indicator of malignancy. The arrow on the right is pointing to an area of tumor necrosis. Tumor necrosis occurs in rapidly growing tumors, which are outgrowing their vascular supply.
Gross photograph of a Pheochromocytoma arising within the adrenal medulla. Pheochromocytomas arise most commonly ( 90%) within the adrenal medulla. The remainder arise within the extra-adrenal paraganglia most commonly below the diaphragm. Pheochromocytomas are derived from chromaffin cells and these tumors secrete catecholamines, with the major clinical manifestation being hypertension. The hypertension is often episodic and accompanied by other signs and symptoms of catecholamine excess, such as: tachycardia, palpitations, sweating and tremors. The majority of pheochromocytomas are sporadic, but up to 25% are familial. In the familial tumors, many arise in childhood and 50% are bilateral. Most pheochromocytomas are tan in color. The darker areas (yellow arrow) represent areas of hemorrhage. The thin rim of yellow tissue overlying the tumor (white arrow) is the adrenal cortex, which is somewhat attenuated. The blue arrow is pointing to residual adrenal gland not involved by the tumor.
Histologic section of a Pheochromocytoma. Note how the tumor cells are arranged into very discrete rounded nests circumscribed by fibrovascular trabeculae (area inside the yellow oval is a good example of this). This growth pattern is referred to as "zellballen" and is the most characteristic histologic feature of a pheochromocytoma. Approximately 10% of pheochromocytomas arising in the adrenal medulla are malignant, whereas 20-40% of pheochromocytomas arising in the extra-adrenal paraganglia are malignant. The histologic features of a pheochromocytoma are not a reliable predictor of the tumor's biologic behavior, so that the diagnosis of malignancy in pheochromocytomas is based exclusively on the presence of metastases.
Section of pancreas showing an islet exhibiting insulitis. The islet is infiltrated by lymphocytes, which is referred to as "insulitis." Insulitis is seen in patients with Type 1 diabetes. Type 1 diabetes is the result of an autoimmune disorder directed against the -cells of the pancreatic islets.
Section of pancreas exhibiting an islet involved by amyloidosis. Amyloidosis of the pancreatic islets is seen in patients with Type 2 diabetes. The amyloid results from the deposition of amylin fibrils. Amylin is a peptide, which is secreted along with insulin by the -cells. Insulin resistance in Type 2 diabetes resulting in a sustained increased demand for insulin secretion underlies the amyloidosis. In long-standing cases of Type 2 diabetes, amyloid may largely obliterate some of the islets (as seen in this example) and contribute to the insulin deficiency seen later in the course in many cases of Type 2 diabetes.
Cross section of pancreas exhibiting an islet cell tumor. The islet cell tumor in this case is an insulinoma. Insulinomas, as the name implies, autonomously secrete insulin. Insulinomas are the most common type of islet cell tumor comprising approximately 80% of the islet cell tumors.
Histologic section of a small insulinoma. Islet cell tumors are most commonly composed of cords or nests of relatively small, uniform, round to oval tumor cells. Insulinomas, as well as the other islet cell tumors, can be benign or malignant. Approximately 90% of insulinomas are benign. Islet cell tumors, even when malignant, do not usually exhibit much anaplasia, so it may be difficult at times histologically to determine whether the tumor is benign or malignant. Signs of malignancy include local invasion, as well as lymphatic or blood vessel invasion.
Malignant insulinoma composed of relatively small basophilic staining tumor cells. Mild anaplasia is evident in this malignant insulinoma (red arrow points to an enlarged hyperchromatic nucleus). Lymphatic invasion is present (yellow arrow is pointing to a nest of tumor within a lymphatic space) indicating the sinister intent of this tumor. Approximately 10% of insulinomas are malignant.
Immunoperoxidase stain for insulin. Normal pancreas is on the left side of the field, and an islet cell tumor is on the right side of the field. The yellow arrow is pointing to an islet of Langerhans in the normal pancreas, which is strongly positive for insulin. The islet cell tumor on the right is positive for insulin indicating that it is an insulinoma. Insulinomas can in some cases secrete enough insulin to result in attacks of hypoglycemia. The attacks of hypoglycemia are often precipitated by fasting or exercise and can cause a variety of symptoms, including: sweating, nervousness, hunger, confusion, and sometimes progressing to stupor and coma if the hypoglycemia is severe enough.
Section of kidney demonstrating two arterioles exhibiting hyaline arteriolosclerosis in a patient with Benign Nephrosclerosis.
LEFT: Section of kidney demonstrating an arteriole exhibiting fibrinoid necrosis (necrotizing arteriolitis).
malignant HTN
RIGHT: Section of kidney demonstrating an arteriole exhibiting hyperplastic arteriolitis/arteriolosclerosis (onion skinning).
Fibromuscular dysplasia of renal artery, medial type. This is an elastic tissue stain, which stains elastic tissue black. The white arrows are pointing at the internal and external elastic lamina. Fibromuscular dysplasia is subclassified into three types: intimal, medial, and adventitial, based upon which layer exhibits the fibromuscular thickening. In this instance, the media (black bracket) is markedly thickened, so that this is a case of fibromuscular dysplasia, medial type. The medial type is by far the most common type of fibromuscular dysplasia.
Section of kidney exhibiting a glomerulus stained for fibrin (fibrin stains red). There are platelet-fibrin thrombi within the glomerular capillaries characteristic of a thrombotic microangiopathy.
Left: Cross section of kidney exhibiting a recent infarct white arrows.
Right: Histologic section of an intrarenal artery occluded by an atheroembolus exhibiting cholesterol clefts blue arrows.
Ischemic ATN. The arrows are pointing at tubules with necrotic epithelial cells and sloughed necrotic cellular debris within the lumen. The arrowheads are pointing at regenerating renal tubular epithelial cells exhibiting enlarged nuclei with nucleoli.
ATN due to mercury poisoning. There is widespread necrosis of proximal tubular cells. The distal tubules (D) are spared.
Histologic section of kidney from a case of acute pyelonephritis. There are numerous neutrophils (PMN's). The arrow is pointing to a tubule which is filled with neutrophils. Large numbers of neutrophils within the renal tubules give rise to leukocyte casts, which are diagnostic of pyelonephritis.
Lower Right: Histologic section of kidney from a case of chronic pyelonephritis. There is marked atrophy of the cortex and medulla with "thyroidization." The arrow is pointing to a calyx which is surrounded by fibrous tissue and somewhat deformed.
Left: Causes of urinary tract obstruction.
Right: Kidney exhibiting hydronephrosis with marked dilatation of the pelvis and calyces and atrophy of the cortex and medulla.
Drug-induced interstitial nephritis exhibiting a mixed inflammatory infiltrate with numerous eosinophils.
Kidney exhibiting foci of papillary necrosis.
Section of kidney from a patient with acute uric acid nephropathy exhibiting a renal tubule, which is obstructed by uric acid crystals.
Section of kidney from a patient with multiple myeloma exhibiting casts in the lumen of the renal tubules (cast nephropathy).
renal papillary adenoma
Renal cell carcinoma, clear cell type (Clear cell carcinoma)
Renal cell carcinoma papillary type
Renal cell carcinoma chromophobe type
Left: Gross photo of a Wilms tumor. The tumor is soft in consistency, tan-gray in color, well-circumscribed, with scattered small cysts and focal mild hemorrhage.
Right: Histologic section of a Wilms tumor exhibiting the classic triphasic growth pattern, with loose mesenchymal stroma, nests of blastema and focal epithelial elements resembling tubules or developing glomeruli (arrow is pointing at a glomerular-like structure).
Left: Gross photo of bladder involved by malacoplakia exhibiting focal areas with a slightly raised grey-tan plaque-like exudate.
Upper Right: Histologic section of bladder involved by malacoplakia exhibiting sheets of macrophages with abundant eosinophilic cytoplasm.
Lower Right: PAS stain of malacoplakia exhibiting macrophages containing abundant PAS positive material. Arrow is pointing at a Michaelis-Gutmann body, which are characteristically seen in this disorder.
Histologic section of a papillary urothelial neoplasm.
Inverted papilloma arising in the urinary tract. There are anastomosing cords of benign transitional epithelium, which appear to be growing down into the lamina propria. This lesion can sometimes be a diagnostic dilemma for inexperienced pathologists. The lack of any cytologic atypia, as well as the absence of any reactive stromal response, indicate that the lesion is a benign inverted papilloma and not a well-differentiated invasive transitional cell carcinoma.


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Style Map
Daily Dispatches From The Global Scene
This year, Marc Jacobs celebrates 15 years as the creative director of Louis Vuitton. And today in Paris, Louis Vuitton—Marc Jacobs, a comprehensive exhibition that explores two innovators and their roles in Vuitton's 143-year history, opens to the public at the Louvre's Musée des Arts Décoratifs. (If you can't make it to Paris before the September 16 closing date, Rizzoli's accompanying tome, with historical and critical essays by curator Pamela Golbin and Jo-Ann Furniss, a look back through the collections organized by Jacobs and Katie Grand, and more, arrives in April; it can be preordered here.)
"When we were talking through the project, what came out was we really wanted to portray Louis almost like a black and white picture, whereas Marc is like a Technicolor film," said curator Pamela Golbin, a celebrated author, fashion historian, and the Chief Curator of Fashion and Textiles at Les Arts Décoratifs. The exhibition is divided between a historical view of founder Louis Vuitton himself and a contemporary view of Jacobs' creation of the house's ready-to-wear, which he founded in 1997 and has stewarded since. Here, Style.com talks to Golbin about creating the exhibition and the history of the influential house.
What does this exhibition say about the development of Marc's career at Vuitton?
First of all, what's so interesting about this exhibition is that it follows two men, so it's about Louis and he has a whole floor, and then also a second floor is dedicated to Marc. When it came to Marc, it was important for him to be very involved in the project. I did not want this to be a retrospective; it's more a celebration of what Marc has done in the last 15 years at Vuitton. And it's incredible that it has already been 15 years. The exhibition is more about the vision that he created for the brand than anything else. And that vision is quite large. It's not just about designing clothes. Obviously accessories are important, but so is advertising, his artistic collaborations, and just his overall cultural vision. So Marc's floor begins with Marc's World. We essentially opened up his head and we did a self-portrait of Marc through all of the cultural influences that he's had and that he uses for his design process. So it's like a giant Tumblr page with still images and video images of everything and anything that has influenced him over the years. It's not at all chronological. It's thematic. And he even came up with the titles for each of the cases.
Why did you want to steer away from doing a retrospective?
The idea was by no means to say, "OK, in 1997 he did this and he did that." His story is not chronological. His story is really about an energy and an attitude. He turned Louis Vuitton from a brand into a house. And so what we tried to get across were the steps that he took to get there and important moments. And more importantly, just really his fashion vision for Louis Vuitton that, when he arrived, was already 143 years old. He really created a fashion entity within a luxury brand.
How does the exhibition demonstrate the impact of Marc's collaborations with artists like Stephen Sprouse (above), Takashi Murakami, and Richard Prince?
Obviously today it's normal for a luxury brand to reach out to an artist or to work on a collaborative project. In 2001, when Marc initiated this, it was not something that was an easy sell, [especially] within a company that was as important as Louis Vuitton. The success was global, and then obviously from Murakami and Prince the success just got bigger and bigger—so now it's a given for any company to work that way. But Marc is really someone who works with a team, and he's never about the "me." He's always about the "we," so it seems organic and quite natural for him to reach out to artists to collaborate on different projects. And in each case, he was able to remodernize the LV monogram, what has now become a cultural icon.
How does the show demonstrate how Marc plays off Louis Vuitton's history and uses the archive?
For example, [as part of the exhibition] he actually explains why he chose such a muted palette for his first collection at Louis Vuitton. He only did pieces that were white, black, and gray, and he explains how, for the first collection, he decided not to use a logo. However, he was inspired by the gray canvas trunk that Louis started with in the 1860s. That was really the "stealth wealth," discreet quality that he wanted to inculcate all of the first collection's garments with. And as he said, everything was on the inside like the inside of a trunk.
How involved was Marc with the realization and curation of the exhibition?
Everything went through Marc. Obviously Sam Gainsbury and Joseph Bennett did the exhibition design. [But] all of the creative team was working on this. Emma [Winter], who works on the bags, was on the project. Faye [McLeod], who does the creative visuals worldwide, was on the project. Katie Grand, who's Marc right-hand person, was also on the project. So Marc says he's not into blank pages. If you put a line, he knows if it should be a circle and if it should be in red and blue and green. That's how we worked. We brought him ideas. We showed him where we were going, and then he reacted and said, "That's exactly what I want." Or, "I don't know about this, let's try this or that." So he reacted to the ideas that we kept feeding him. And what was so exciting was to be able to be a part of that creative process.
We've talked a bit about Marc. Tell me a bit about the Vuitton aspect of the show.
The Louis Vuitton brand is known worldwide, [but] what really interested me was Who was Mr. Louis Vuitton? Because people tend to forget that behind a brand, there's always a person. And it was the person that really enticed me into this project and seduced me. So the more I learned about him, the more I wanted to understand what relevance he has today.
On the first floor, we trace Louis and put him in the context of Parisian fashion. During his time, it was the birth of the haute couture Parisienne. And Louis was very close to the founder, Charles Frederick Worth. So we were able to find a trunk with the actual plaque from Charles Frederick Worth. Putting Louis further into context, we brought out a collection from the fashion museum from our collection and really show not only the quantity of clothes that were necessary for a woman at that time but also the volume that those clothes took up, so you can really understand why you would even call someone like Mr. Vuitton in the 19th century so he could come and pack your bags. Then, all of his signature styles were shown at the World Fair. Through documents, we also show the actual innovations he presented at these universal exhibitions.
As someone who has studied the history of so many iconic brands and designers, what did you find most interesting about the history of Vuitton?
I think it was how modern Louis was. And also how perfectly in tune Marc has been and how clever he has been in creating the fashion facet of such an incredible company. And Marc himself always says that he created this parallel universe. He didn't want to set aside the history. On the contrary, he's created something on top of what already exists. He is able not only to appropriate the history, but also create something new that still takes into account the almost two centuries that have passed.
Are there any aspects of the exhibition that we haven't touched upon that you'd like to highlight?
There are so many moments that were challenging because of time and space. But there were also so many moments of just pure humor. I think humor is really important. And when you're speaking about history, it's always a little delicate. But when we were working on the Marc part, it was really exciting to be able to get that across, because humor is such a big part of who Marc is. From the beginning I wanted Marc to be present. And at the end, when you see the show, there's actually a mini 40-cm-high Marc doll that says, "Bye, guys" to all the viewers. And it's literally a miniature of Marc. He was scanned three-dimensionally with all of his tattoos. The whole nine yards. He's wearing the uniform he always wears—his white shirt and his kilt, and he even has the LV diamond studs that were done miniature for him. I think it's a wonderful example of how incredible this company is.
Wish we could be there! http://www.sharedesign.com
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subset: commoncrawl


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Recruits doing work
Sounds like our big recruits are still trying to go after smith and EO. This is big as many major programs sustain recruits this way. While I am still not exactly sure what happened with the orange fizz writers and ishaq williams,mand I think they should not be trying to contact recruits again, I appreciate the update.


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Peter Frank:
Rarely, do I get to witness such hysterical feigned outrage, and profound ignorance, no less see it in print.
Nobody is telling you, as a quite obvious citizen of Schenectady, what you can, or can not buy.
In fact, that matter has never even been brought up.
Despite whatever Malady Burns, or whatever tea party alarmist has told you, that particular attempt at ill thought legislation, only applied to New York City.
"This editorial also brought up the five-round magazine limit under the new SAFE act."
I believe the number you are looking for, is SEVEN, and that provision is over with, but don't let facts get in your way.
Currently, they are suggesting that one should use the existing 10 round clip, and only load it with 7 rounds, unless they are at home, or at a range.
"I wonder which would make our schoolchildren safer: yet another law, or an armed teacher?"
This just in:
Most of those whom aspire to be teachers, don't harbor fantasies of being the next Rambo, and for the most part know that they, themselves, are not comfortable around firearms, in ANY situation.
Who exactly, do you propose, are going to pay for the astronomically higher insurance premiums that the school district would have to pay if the staff were to be armed?
Certainly not you. You didn't even pay for your own tuition.
I did, I paid for you, and your's, and shall for the rest of my life, despite the fact that I have never attended a public school.
Uh-Oh SOCIALISM!
Bear in mind, you live in a second world city, that can't even get a car loan.


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An amazing fiber-filled recipe for hot weather.
Latest Fitness
A celebrity trainer spills on how to DIY a personal workout
Easy lunches perfect for warm weather.
Say goodbye to constipation; relief is in your reach.
- Jillian Michaels gives her advice for getting seriously fit this Summer — Shape
- 5 reasons to use kettlebells — Mind Body Green
- The reasons you aren't losing belly fat — Health
- All you need is a couch to do Alison Sweeney's workout — Fitness
- Even more reasons to love Greek yogurt — POPSUGAR Beauty
- Run faster? Yes, you can! — HuffPost Healthy Living
- The best superfoods for weight loss — Self
- Find out if you should really do a juice cleanse — Real Simple
A low-calorie cocktail perfect for warm weather.
No juice cleanse is required.
Check out that and more stories from across the POPSUGAR network!
Rule 1: Love who you are.


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By Meira Beinstock
For The Herald Bulletin
Besides the fact that companies sited along Interstate 69 are within a day's drive of more then half the U.S. population, being located on I-69 has other advantages, according to DeWayne Landwehr, executive director of The Flagship Enterprise Center.
The interstate runs in close proximity to I-70, I-65, and I-64, he explained, and Indiana is considered one the best states to locate a business because of several factors: tax climate, low cost of living, cheap real estate, low taxes and the presence of multiple logistics firms that cover every type of transportation.
"I can't imagine why you wouldn't want to have a business along the I-69 corridor," Landwehr said. "It's just like any business you have; the closer you get to the interstate, the more expensive the land is. So if you can locate a few miles off the interstate, land is less expensive, but I'm hard pressed to come up with a disadvantage."
The Flagship Enterprise Center at Exit 22 was created in 2005. The business incubator has helped more than 100 companies get a start. Those 100 companies, together, now employ nearly 1,000 people.
The Flagship's immediate area is home to several other businesses, including a massive Nestle production and distribution facility, Walker Research, Central Indiana Orthopedics and Carter Express.
Nestle's operation has grown to include 800 employees, and one of the call centers now employs more than 1,000, according to Landwehr.
"There is a CPA pro that has grown from a very small office in downtown Anderson to an office out here, and they've really expanding their workforce," Landwehr noted. "They're probably double what they were a year or two ago,"
"If you live here and you drive here every day, you can see growth coming right up from Indianapolis," Landwehr said of the I-69 corridor. "There's almost always a building under construction. ... In a few short years, it's going to be solid with businesses from Indianapolis."


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Nintendo are working on an expansion to the Mii channel...
See the full article here>Nintendo Co. Ltd is developing a new channel for its Wii console that will allow gamers to compare their Miis -- customized virtual avatars that people can play in Wii video games.
During a speech at the Game Developers Conference in San Francisco, Nintendo game creator Shigero Miyamoto said the channel, to launch soon, will enable gamers not only to share their custom avatars, but to vote on them in popularity contests, adding another level of stickiness to the online functionality of Nintendo's $250 next-generation console.
hmmm interesting!


text:
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SOURCE Weatherford International plc
ZUG, Switzerland, July 31, 2014 /PRNewswire/ -- Weatherford International plc (NYSE: WFT) today announced that it has scheduled a conference call for Thursday, October 23, 2014 at 8:30 a.m. ET. The purpose of the conference call is to discuss results for the Company's third quarter ended September 30, 2014. The call will be open to the public.
To access the call, please contact the conference call operator at 866-393-8572, or 706-643-6499 for international calls, approximately 10 minutes prior to the scheduled start time, and ask for the Weatherford conference call. The passcode is "Weatherford". A replay will be available until 5:00 p.m. ET, November 6, 2014. The number for the replay is 855-859-2056, or 404-537-3406 for international calls; passcode 83135858.
An enhanced webcast of the conference call and replay will be provided by NASDAQ OMX Corporate Solutions and will be available through Weatherford's website at http://www.weatherford.com. To access the conference call and replay, click on the Investor Relations link and then click on the Enhanced Audio Webcast link. The webcast requires Microsoft® Windows Media Player. If you experience problems listening to the broadcast, send an email to firstname.lastname@example.com.
Weatherford is an Irish based, multi-national oilfield service company. It is one of the largest global providers of innovative mechanical solutions, technology and services for the drilling and production sectors of the oil and gas industry. Weatherford operates in over 100 countries and employs over 64,000 people worldwide.
Krishna Shivram
Executive Vice President & Chief Financial Officer
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Vice President - Investor Relations
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Cirque du Sol-Radian
Acrobats and jugglers and accordionists, oh my! These performers have been spotted outside the Radian for the better part of the week, despite the ungodly temperatures hitting Philly (they work hard for the money). Anyone know their deal?
Tags: News, accordion, acrobat, cirque du soleil, juggler, performance, radian, wtf
Previous post: Hoodie Allen Holds His Own (Solo Cup).
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Tags blues, blues rock
Genres rock n roll, classic rock, oldies, rock, rock and roll (beta)
(flag as incorrect)
Artists The Platters, Elvis Presley (beta)
April 22, 2012
My favorite Elvis songs
Make love to your soulmate by inagudrun
9 tracks.
trip-hop, sexy, love
Night Owl by inagudrun
I like to study at night when it´s dark, this is my study-night playlist.
dark, studying, midnight
Hurricane Drunk by inagudrun
songs to listen to when drunk.
alternative, blues
Flannels, jeans and boots by inagudrun
A few of my all time favorite songs from the 90´s.
90´s, grunge, nostalgic


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Authorities are investigating whether two separate shootings that injured five people are linked to the same fight at a Bibb County nightclub early Sunday.
The first shooting happened outside Scarlet Carson's nightclub on Cavalier Drive around 3 a.m., according to a Bibb County Sheriff's news release.
The release says three Macon men were shot during the fight. Police say they are: Marvin J. King, 25; Kendrick Hill, 24; and Willie Currie, 23.
As of Sunday afternoon, Bibb Sheriff's Sgt. Sean DeFoe said Hill was discharged and the other two were in stable condition.
Macon police say several minutes later two more men were shot.
Sidney Bishop, 21, and Jadarius Shinholster, 21, were shot in the back after they left Scarlet Carson's, the release said. The men were shot as they were driving around Mercer University Drive and Columbus Road.
The men who shot at Bishop and Shinholster were driving a gray Nissan Altima or Maxima with medium tinted windows and 20-inch chrome rims, police say. The injuries are believed to be non-life threatening and both are in stable condition.
The news release says Bishop, Shinholster and another person were also involved in a fistfight at Scarlet Carson's. Police are trying to find out whether the two shootings are related.
If you have any information contact 1-877-68-CRIME.


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A collection of photographs remembering a family home of sixteen years in rural Missouri.
Acerca del autorDeanne and Byron McKeown
ravenlady Sedona, Arizona USA
Byron and Deanne McKeown have spent the many years of their lives together as artists exploring possibilities. The cross collection that appears in their book, 'Cross Culture', has been created through their love of travel and research. The history of each cross has been carefully researched in America and Europe -- the actual pieces created by hand, then cast in sterling silver, bronze or gold. The McKeowns have lived in Sedona, Arizona for thirty years and have owned three galleries there, featuring their own work. They create in a variety of media: Byron works with metals and wood, creating collectable walking sticks, letter knives and collages. Deanne designs jewelry, works in clay and wax to create bronze sculpture and explores two-dimensional media.
Fecha de publicación 12 de agosto de 2008
Dimensiones Cuadrado pequeño 30 páginas Papel estándar
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An Evansville man, convicted of murder, has been sentenced for his part in a deadly shooting.
25-year-old Michael Lane was sentenced to 55 years for murder, 4 years each for two class C felony counts of criminal recklessness, and 10 years for felony conspiracy to deal drugs.
The shooting killed a man named Michael Hooper, and left two others seriously wounded.
Jason Derrington's spinal cord was severed by gunshot.
According to police, Lane began shooting when he tried to steal back his cash during a drug deal.
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Pick 20 - Brandon Pettigrew TE
Pick 33 - Darius Heyward-Bey WR
Pick 65 - Jennings, RB - Liberty
Pick 82 - Hill, DT Stillman
Hey, why not? Congratulations Mayhew, you really are NO different than Millen. We are the same organization the Bungles were 10 years ago. Oh wait, I forgot, the Bengals never went 0-16. It's clear that no one in this organization has a clue as to how to build a winning team, nor do they care.
I promise you this much. This idiocy will never see another dime from me or my family until I see a winning record. I will never attend another game, I will never buy another jersey, and I will tell all my family members I want nothing Lions for Christmas, birthdays, etc. I'm tired of gimmicks, and this is the most pathetic one I've seen yet. So guess what Ford, kiss my cash goodbye until I see a winning product. My guess is the old windbag won't care, but oh well, I'm not throwing good money after bad.


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It's a brave new world at Fifteen
Posted: February 09, 2013|
BRISK February winds whip across the beach as ice-white waves hurl themselves onto pristine sand. Even on the chilliest of days, the views across Watergate Bay are spectacularly beautiful.
Overlooking the bay stands the Fifteen Cornwall restaurant, where diners absorb the unique setting while scanning the menu for delectable temptations.
Since its opening, it has built up an enviable reputation for fine food and drink while training some of the county's most disadvantaged youngsters in the restaurant industry.
It reopened on Saturday following a brief closure for a £500,000 revamp.
Builders ripped out the bar, kitchen and the entire restaurant interior, including the ceiling and floor – even the restaurant's trademark pink graffiti wall was swept away.
The facelift has been relatively rapid, with the restaurant having only shut in mid-January.
Step inside the welcoming warmth of the restaurant now and the changes are immediately apparent.
In the dining area, the restaurant's recognisable pinks and greys have vanished to make way for a more glamorous palette of white, greys and metallic silver, with the merest trace of orange.
However, upon closer inspection, the faintest whisper of Fifteen's original pink lingers among the new decor.
New additions include an antipasti bar where customers can be waited on under a shimmering chandelier.
The elaborate adornment was created with 38 individual lights, each one made of hand-blown glass, reflected in a wall of antique mirrors.
The kitchen remains open-plan, but has been opened up even more to give the 17 professional chefs and 20 apprentices extra working space.
Diners will now have an even better view of the team busily working their culinary magic amid an orchestra of boiling pans and shining knives.
Jamie Oliver gave the overhaul his blessing.
"Fifteen Cornwall has been open now for six wonderful years, and so it was definitely time to give it a bit of a facelift and put some love back into the four walls," he said.
"The guys have created a brilliant place for our apprentices to learn, develop and hone all their skills and, of course, there is nothing else like it in the South West. I'm ridiculously proud."
There were a number of reasons for the overhaul, as chief executive Matthew Thomson explained.
"It's important to secure growth for the business for its long-term stability," he said.
"Tourism-wise, Cornwall had a difficult 2012 because of the recession, the weather and the Olympics. Like lots of other restaurants, we saw fewer customers coming through the doors.
"And, since we launched, more top-quality restaurants, including those run by Nathan Outlaw and Paul Ainsworth, have opened up so there's obviously an element of extra competition.
"If people are travelling to Cornwall on holiday and maybe having two or three special meals out then we want to be one of those two or three."
The new kitchen cost three times the amount of the old one and should last for 15 to 20 years.
A team of innovative British designers from Gloucester-based Space drew-up the blueprint and installed the kitchen, but the pièce de résistance is a £90,000 French-made oven called an Athanor suite.
Actually, it would be inaccurate and unfair to simply describe it as an oven – it is in fact a 20ft-long "hot island" in the middle of the kitchen. The island has a gas oven, hot plates, two hobs and a pasta boiler.
Head chef Andrew Appleton had a major say in the new design and regards the centrepiece as an absolute godsend.
"Everyone can work around the hot island, which creates a better workflow around the kitchen," he said.
"It's so much better for the apprentices because they've got more space to stand next to one of the professionals to watch what's going on.
"It's even more open-plan than before, so customers can enjoy the theatre of the kitchen."
The new kitchen was a year in the planning and extra space was the main ingredient.
"Don't get me wrong," said Andy. "I've worked in some terrible basement kitchens in London with hardly any room – the old kitchen we had at Fifteen was not the worst I've worked in by a long chalk.
"But it was pretty cramped and equipment was beginning to break down and had to be replaced, which could prove costly.
"It's a bit like when things start to go wrong with a car and you have to keep having work done to keep it running.
"After a while you're just throwing good money after bad and it's better to buy a new one.
"One of our old ovens kept breaking down and it became a bit of a nightmare. There were times when we were left with only one gas stove to work on and 150 people booked in for lunch, which was no joke.
"But because we're an open-plan kitchen we just had to carry on as if everything was totally fine.
"Somehow you get through it – you just have to work with what you've got."
His particular pride and joy is the new charcoal-fired £10,000 Spanish-built Josper oven – essentially an indoor barbecue.
"We're well-known for our fish dishes, but I really want to start pushing beef further up the menu," he said.
"The restaurant is growing up and we're going to offer more choices."
With one of the busiest nights of the year just around the corner, staff will be testing the new kitchen to the maximum.
"We've got Valentine's night coming up and it will be great to be in a new kitchen.
"It's been brilliant watching the whole project come to life from early designs to installation," he said.


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Rick Ballou out of Jacksonville is reporting that Florida State's starting center will miss the Savannah State game.
Bryan Stork out this sat w injuries. Barron will start at center. Not a big deal but he will be needed when they play the BRUTAL acc #FSU— Rick Ballou (@Ballou1010xl) September 6, 2012
Of course, the starters aren't likely to play much anyhow.
FSU's Opponents
GT Film Review: Hokies Unveil their New Offense | The Key Play
Imagine my surprise when I watched the film, and realized that almost none of my initial assumptions were accurate. The offensive line wasn't dominant, but for the most part achieved at least a stalemate up front. I saw very few missed assignments. While the offensive system is still a hodgepodge of different formations and fundamental elements, the play calling utilized a true system approach, with appropriate counters being in place to keep the defense off balance. Also, we saw the coaches utilizing multiple formations and personnel groupings on each series. The wide receivers have some issues, especially with getting separation, and if there is a fair criticism of the coaches and the receivers, it is the lack of vertical passing attempts to prevent the Georgia Tech safeties from crowding the line of scrimmage. When Thomas hit Knowles deep, it wrecked Al Groh's entire defensive concept. For the most part, we saw the same offense against Georgia Tech that we were so excited about in scrimmages. So, what really went wrong?
This is like the Tomahawk game breakdown, except for Virginia Tech. If there is one thing you read today, make it this.
Warchant.com - FSU open to replacement for Nevada on 2013 schedule
Free story. Nevada is trying to get out of the Florida State game by finding a replacement to play FSU.
D.J. Coles Done For The Year Due To Knee Injury, According To Report - SBNation.com
Virginia Tech wide receiver, injured during the season opener against Georgia Tech, is done for the year.
Special topics in football food | Campus Union
September is upon us, gentle readers. Have you a gameplan? As a grateful nation settles into the glorious grind of football season, it behooves us to be prepared for the onset of conference play — prime tailgating time. Campus Union spoke with Southern Living Test Kitchen director Rebecca Gordon, West Coast food blogger Sarah Sprague and East Coast food blogger The Gurgling Cod on a range of topics, from food safety to meal planning to the sacred art of cooking an entire pig before a game. Read on, and may your parties be championship-caliber from sunup to cleanup.
The Oklahoma Offense: Was Last Year's Funk The New Normal? - SBNation.com
Reacting to a single game can so often make you feel foolish. Oklahoma could hang 70 points and 700 yards on Florida A&M, then reprise last year's near-perfect performance in Manhattan when Kansas State comes to town. They could get their revenge on Texas Tech in Lubbock on Oct. 6 and head Dallas to face Texas as a legitimate Top 2-3 team. By then, all of the hand wringing about the Sooners' ghastly first three quarters in El Paso could feel pretty silly. But in their first opportunity to prove last year's struggles are behind them, they did no such thing. And it is probably also silly to simply assume the offense will come around in 2012. There is a lot to like on paper, but that was the case last year, too.


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News: Young Jeezy's "Thug Motivation 103" Gets Plowed Back
Monday, Oct 11, 2010 5:45PM
Southern rapper Young Jeezy's delayed Thug Motivation 103 album has reportedly been pushed back to a Christmas season release.
According to reports, the "Snowman" will plow his album into stores around mid-December.
Young Jeezy has had a tough time motivating the thugs this year. The third installment of his Thug Motivation series, TM103, has been facing delays ever since last year, but reps for Def Jam have confirmed with XXLMag.com that the disc will finally hit shelves on December 14. The Atlanta-based rapper already dropped several singles from the album--"Jizzle," "All White Everything" featuring Yo Gotti and "Lose My Mind" featuring Plies--to little fan fare. (XXL Mag)
In a recent GQ Magazine feature, Jeezy revealed the new work ethics he explored while working on the new album.
The album is like a hip-hop version of the Stones' Exile on Main St or Dylan's Basement Tapes: To make it, Jeezy went completely off the grid, descending in early 2010 into the basement studio in producer Shawty Redd's south Atlanta home. He didn't come out for three months. The vibe was different from what the Stones had in the South of France, however. Redd had recently returned home from jail on a murder charge, posting $200,000 in bail. (A trial date is still pending.) Jeezy begins the story of the sessions like this: "I had just got off tour with Jay-Z when Shawty got home. I went to his crib, we chopped it up, and finally I said, 'I'm gonna go home and grab my stuff.' Shawty was like, 'Grab what stuff?' I came back with all my clothes and sh*t and moved in." Jeezy hung a flat-screen in his new bedroom and even stocked the cupboard with his favorite cereal, Cinnamon Toast Crunch. (GQ Magazine)
Producer Drumma Boy recently talked about working on Jeezy's new album.
"With Jeezy, it's funny because when it comes to the music, I already know what he wants," Drumma said in an interview. "We've never actually worked in the studio together. The first time I ever heard 'Put On' was on the radio. [Laughs] Just the other day, he called me as soon as I woke up. First call of the day. He was like, 'Where you at? I need to get some more music.' I'll give him the intersection I'm at and he'll just ride down right then, pick up a beat CD and keep it moving. It's like a real dope deal. I really got crack! [Laughs] All our joints come that way. Even with [the album's street single] 'Lose My Mind,' I didn't hear that until we mixed it. So I can't tell you exactly what I've got on there yet, but in addition to "Lose My Mind," I'm gonna have two of three other joints on the album." (VIBE)
Jeezy previously discussed what rap fans could expect to hear from the upcoming project earlier this year.
"But June, by the way," he said of the LP's release date. "That's what I'm thinking. If you the boss, you can talk like that. I'm thinking June. I wanna own the summer. If you coming out [with an album] in June, you might wanna think about that, bruh. TM103, I will be there...I'm just going in, basically handling my business. I gotta say what's on my mind. But I'm not here to sell you on no album. Like I said, June, you will be surprised, homie. That's real talk. I been working on this. I been back in the lab...I got you." (MTV)
Young Jeezy's Thug Motivation 103 is scheduled to drop Tuesday, December 14th.
Check out a past Young Jeezy interview down below:


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Pensioners protest as bus service is axed (From Daily Echo)
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Bluestar's Solent Shuttle X27 is too costly to run, say bosses
8:46am Friday 9th January 2009 in Travel By Simon Carr, Eastleigh Chief Reporter
A BUS service used by thousands of pensioners, workers and shoppers is facing the axe for the second time in 18 months.
The X27 Solent Shuttle between Southampton and Portsmouth was almost ditched in the summer of 2007 before a U-turn which reduced it to a two-hourly service.
Now the route is set to be scrapped because bus company Bluestar says it costs too much.
Operations director Andrew Wickham said the firm was losing £1,500 a week on the service and it would end on February 22.
However, Southampton Pensioners' Forum and its sister group in Portsmouth are joining forces to fight the decision.
Forum secretary Don Harper said: "This could be a disaster for people who use the service. It is vital that we do all we can to keep this up and running. You never see this bus empty, it always has loads of passengers."
A protest is planned for the final day of the service. Pensioners are planning to travel on the X27 from Portsmouth to Southampton and stage a demonstration with placards and signs.
Mr Wickham said the company did not want to cut the service but had no choice.
He said: "We are the fourth operator to try to make this route work.
It is just too costly and we don't make enough revenue. We are sorry this will have an effect on all the people that use it but it is just too expensive to run."
He said the route used to be supported by Southampton and Portsmouth local authorities but both stopped funding after Bluestar took over the contract four years ago.
He blamed the company's heavy losses on the free bus passes for the over-60s, claiming it was not sufficiently reimbursed.
Asked what it would take for the company to keep the service going he said it would be necessary for the Government to look at the way bus operators are reimbursed for bus pass users or for the local authorities to reintroduce their subsidies.
A Southampton City Council spokesman said: "We used to jointly fund the service with Portsmouth but when it withdrew we decided we couldn't make up the shortfall.
"Because of this Bluestar decided to cut the frequency of journeys from hourly to once every two hours and make it purely commercial.
"As the council has no further budget for subsidies at the moment it is unlikely that we would be able to provide funding, but we are constantly reviewing our subsidised services."
The shuttle runs six return services a day on weekdays and five on Saturdays.
The Daily Echo understands that rival Black Velvet is currently looking at whether it could make a profit from the route.
Comments (13)
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9:13am Fri 9 Jan 09
Paramjit Bahia says...
Privatisation of public transport has been a disaster. Although while in opposition New Labour opposed it, but in power since 1997 they have refused to solve this problem, by kicking out profit oriented privateers out of this business .
9:23am Fri 9 Jan 09
Condor Man says...
9:50am Fri 9 Jan 09
goard says...
10:24am Fri 9 Jan 09
Andy Locks Heath says...
Isn;t it funny how all the things we want our taxes to pay for - eg education, health, transport, care for the elderly etc we can't afford, yet they take second place to things we don;t want - such as wars that others won't fight, a bail out of Icelandic incompetence, a burgeoning public sector full of non jobs, index linked pensions we can no longer justify, illegal immigration, the "human rights" of terrorists we are scared to repatriate.......
11:56am Fri 9 Jan 09
Bright Spark says...
12:33pm Fri 9 Jan 09
Northamboy says...
Bright Spark wrote:Used by thousands but they all have free passes :-)
Used by thousands? Surely this is a slight exaggeration.
12:33pm Fri 9 Jan 09
Northamboy says...
Bright Spark wrote:Used by thousands but they all have free passes :-)
Used by thousands? Surely this is a slight exaggeration.
3:41pm Fri 9 Jan 09
Paramjit Bahia says...
Andy Locks Heath wrote:Andy you have made very valid points. In some developing countries like India both nationalised and privately owned bus services operate comparatively cheaper and reliable (Although state of buses is no so good) services, because remedies you are suggesting are implemented.
I'd half agree with you Paramjit but there is nothing wrong with the profit incentive in transport - earning a profit requires efficiency, hard work and a lot of planning - it doesn't just happen and the idea of money just rolling in to fat cats is an unrealistic myth. But I do strongly agree with you that privatised public transport should be actively regulated by both central and local Goovernment with integrated timetabling, multi modal through ticketing and subsidy of loss making services but not on a pound for pound basis - there needs to be an incentive to make the private company work to reduce subsidy or lose the franchise. All these things the Government could have rectified and hasn't. Isn;t it funny how all the things we want our taxes to pay for - eg education, health, transport, care for the elderly etc we can't afford, yet they take second place to things we don;t want - such as wars that others won't fight, a bail out of Icelandic incompetence, a burgeoning public sector full of non jobs, index linked pensions we can no longer justify, illegal immigration, the "human rights" of terrorists we are scared to repatriate.......
In our advanced UK we as as society have become so relaxed that we do not hold our politicians to account properly, and let them get away with easy life.
Fight against terrorism and other matters raised by you have become a joke. How can they be serious in fighting terrorism when first Blair and then Brown gives millions of pounds Pakistani intelligence which is well known for spreading terrorism. Also while life is made hell for genuine immigrants, all crooks have to do is tell the authorities that they have killed X number of innocent people in their homeland and are wanted as terrorists. Hey presto you are welcome.
Our admin structures are breaking down faster than melting polar ice. Public transport is only one of the victims.
6:20pm Fri 9 Jan 09
The Funky Monkey says...
9:25pm Fri 9 Jan 09
gorf says...
why cant solent blue line put an eco friendly single decker on the route?
2:40am Sat 10 Jan 09
ninebob says...
9:01am Sat 10 Jan 09
Phantomdoll says...
If Velvet decide to continue with the route, good luck to them. I don't much care who runs it provided I can easily visit my family when I wish (without using the car) and also that the bus keeps to the timetable - which Blue Star is not famous for!
12:07pm Sun 11 Jan 09
firstname.lastname@example.com says...


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Barron County (Press Release) - On Saturday, April 20th at 5:04 a.m., the Barron County Sheriff's Department responded to a call at 800 South Limits in the Village of Cameron for a domestic abuse incident involving Jeff Young, 28, and his mother, Connie Young, both of Cameron.
When deputies arrived, they discovered that Young had left the residence. While deputies were searching for him, they received a report that Young had stopped at another residence and took possession of a 30-30 rifle.
At 5:56 a.m., a Rice Lake Police Department Officer located Young's vehicle traveling on W. Knapp Street in the City of Rice Lake. A high risk stop was conducted on this vehicle by a Rice Lake Police Department Officer and a Barron County Sheriff's Deputy.
Due to the severity of the incident and the potential for Young to be armed, and furthermore, Young's actions and failure to comply with officer's commands, K-9 Robbie was deployed to apprehend Young and he was taken into custody. The uncased 30-30 rifle was located in the front seat of the vehicle.
Young received minor injuries from the K-9 apprehension and was treated for these injuries prior to being transported to the Barron County Jail on possible charges of strangulation and suffocation, OWI, battery, criminal damage to property, going armed with a firearm while intoxicated, domestic abuse and a probation hold.


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Lost Arrows are blade pitons that are not only superb and useful climbing tools but also works of art. Lost Arrow pitons, originally designed by John Salathé in the mid-1940s, are the one piton that every serious aid climber has to have on his rack of big wall equipment.
John Salathé Designs First Lost Arrow Pitons
John Salathé, an immigrant from Switzerland and a blacksmith, began rock climbing in 1945 at age 46 in California. As an older climber, Salathé was unable to free climb as well as younger climbers so he turned his attention to aid climbing. He found that the soft iron pitons in common use deformed when hammered into granite cracks and were difficult to remove without damage, so as a blacksmith he began making his own pitons. At the forge in his San Mateo Peninsula Ornamental Iron Works, Salathé made strong pitons using the chrome-vanadium axles of old Model T automobiles. These new pitons could be bashed into Yosemite cracks without bending and buckling. Using his new pitons he turned his attention to climbing big walls. The first was two attempts on the unclimbed Lost Arrow Spire in Yosemite Valley in 1946. Using his new pitons, the prototypes of today's Lost Arrow pitons, he aided to a blank section 30 feet below the pointed summit.
Chouinard Equipment Makes Lost Arrows in 1960s
Based on Salathé's prototype blade pitons, Yvon Chouinard, Tom Frost, and other climbers employed by Chouinard Equipment, began hand-forging the pitons in the early 1960s, calling them Lost Arrows. The elegant design of the pitons slowly evolved and by 1963 they began using die-forged blanks for the pitons. Tom Frost recalls, "…the die kept wearing out, so each time I would re-think the piton design and improve it." Improvements included a beefier neck that could withstanding the beating that Lost Arrows took on Yosemite's big walls.
Lost Arrows are Taped Blade Pitons
Lost Arrows are tapered blade pitons with the eye for clipping a carabiner set at a 90-degree angle in the head of the piton. The pitons range in length from three inches to seven inches. Thickness varies from thin to thick. The strong, rigid pitons excel in a wide variety of crack sizes and, when pounded to the eye in a crack, form a solid anchor for belays, rappels, and lead protection.
Lost Arrows are Durable and Versatile
Lost Arrow pitons are extremely durable as well as versatile. They fit in thin cracks that are too small for an angle piton, small cam, or nut but are too big for a knifeblade, Pecker, or Tomahawk. Lost Arrows, sometimes referred to as LAs, are durable and last a long time, which is great because they usually take a lot of beating on aid routes.
Lost Arrows are Not Essential Today
Back in the heyday of Yosemite big wall climbing in the 1960s and 1970s, Lost Arrows were essential for success but now, with all the clean aid gear available, Lost Arrows are relegated to an extra on most aid climbing racks. Most modern aid climbers usually carry only the #1 to #3 Lost Arrows, the shorties, which are most useful. The longer Lost Arrows are used less often on aid climbs. The Long Dong is often used as a nut-cleaning tool. Lost Arrows are also good for use in stacked piton placements when the pins are placed back to back or paired up with an angle piton in a shallow placement. They're also good if pounded in a half-inch or so and tied off with a loop of webbing.
Lost Arrows Come in 8 Sizes
Lost Arrow pitons, manufactured by Black Diamond Equipment, come in eight different sizes-Short Thin, Short Medium, Short Thick, Wedge, Long Thin, Long Medium, Long Thick, Long Dong.


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Today's weather forecast: A Brief Respite
Q: What is that giant chair on Hill Street across from the courthouse?
A: The 40-foot Shaker ladderback—sorry, Goldilocks, you can't sit on it—was a gift from the Chicago Merchandise Mart to its L.A. cousin in 2003. Many an oversize object dots the Southern California landscape and has become known around the world. We have a half-dozen huge doughnuts, a beer barrel in the Valley, and the Brown Derby atop a mall in Koreatown.
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Any restaurants out there need some help? Here is your chance to get Gordon Ramsay to "come into your establishment to troubleshoot your problems and try to get you back on the road to success." That is what Ms. Jen Apploff, the Casting Producer for FOX's "Kitchen Nightmares" tells me. Here's here deal:
If you are a restaurant owner fill out the application online at: www.theconlincompany.com and email it back to: email@example.com. Restaurants must have been open at least one year, offer dinner service, and have at least 35 seats. Questions? Email: firstname.lastname@example.com.


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By admin on 31-05-2011
Morgan Ailis Webb is a co-host and senior segment producer of the G4 show X-Play, and host of the show G4 Underground. She was previously the host of the podcast WebbAlert and a monthly columnist for the United States edition of FHM, where she contributed a monthly video game column entitled "Tips From The Gaming Goddess". And she is a beautiful woman for sure. Here we have Morgan Webb upskirt photos that were taken right in the studio.
You see that headphones? She prepared herself for the show and forgot to control her skirt. We are lucky, please, let's make it double. Morgan Webb upskirt pictures is really a good thing to see. I think all guys, especially her listeners, will love what they see. And they see her panties! What a naughty girl! Morgan, don't disappoint us, give us just a couple of seconds more. Yeah, thank you, darling!


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The Mississippi Highway Patrol is investigating a two-vehicle crash which occurred Tuesday in Jones County. Authorities say an unidentified Jasper County man was injured in the incident.
The Jones County Fire Council says several volunteer firefighters and first responders were dispatched to the scene where they found an MDOT truck and trailer had collided with a Toyota Camry.
The truck driver was not injured. The Camry driver is hospitalized with serious, but non-life threatening, injuries.
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At the Half
Thoughts on Michigan: McGuffie is running well in the Zone Blocking scheme, Threet has hit the vertical passes beautifully. I don't care if Michigan is down by 11, they've shown more promise in 30 minutes against ND than against Miami (OH) and Utah.
(PSU 35, Cuse 6)
Thoughts on Penn State: Clark has shown he is a run-pass threat in every Penn State game. Syracuse is a program in a rut, but Penn State's offensive efficiency is still impressive.
(Purdue 20, Oregon 6)
Thoughts on Purdue: Holding Oregon to field goals is the key to this game. Purdue scored quick, but hasn't looked impressive on offense. Oregon will come back - can the Boilermakers hang on for a season altering upset?


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Jayda Evans' Live Game Thread: Seattle hands Minnesota first loss of 2012
Jayda's blog with a running courtside account of the Seattle Storm's 65-62 win over the previously undefeated Minnesota Lynx. From the Storm: The Lynx's 62 points were 16 below their previous season low (78, 6/15 at PHO). Their 37.5% shooting and 25.0% on threes were also season lows. Minnesota's 10 first-quarter points were the fewest the team has scored in a quarter this season (previously 11) and tied the fewest allowed by the Storm.


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Celebrity Central / Top 25 Celebs
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I will pick up & transport your pet(s) to the Vet or groomer for $25 per hour (first 10 miles free, then 50 cents each additional mile). I will stay with your pet if needed, or drop off and pick up when ready to return home.
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takes place annually, since 2006, on the beautiful Mediterranean island of Cyprus. The festival is a non profit organisation and it was inaugurated on March 23, 2006 by the Cypriot Minister of Education and Culture Mr Pefkios Georgiades. It is Under the Auspices of Municipality of Nicosia. The Cyprus International Film Festival is the biggest of artistic high value cinema event of the whole region, spilling over Cyprus' boundaries and spreading over the whole region with repercussions reaching worldwide.CΥIFF is the first internationally oriented film festival which offers new and upcoming directors in multiple sectors of entertainment (such as feature films,short films, animations, music videos, dance films and video art) the opportunity to showcase their talent in front of a jury of internationally acclaimed cinema experts, directors and actors. CYIFF has a competitive section. Films produced the last 36 months, by emerging directors are selected for the screening program.
CYIFF promotes both Cypriot film directors and Cypriots artists living abroad through the film category "NostimonImar" and awarded Cypriot Film Directors, as well as the history of Cyprus. The festival and the parallel events create an important meeting placefor Cypriots and foreign filmmakers.
The prize "Golden Aphrodite" is being judged by a distinguished panel of experts in the international film industry.
The awards are the "GOLDEN APHRODITE", film reels as well as crew services and shooting equipment prizes. Equally unique is the condition that these prizes must be utilized for their next project and spent in Cyprus and/or Greece.
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24 Nutritious (and Tasty) Snacks
One-inch cube of hard cheese (like aged Gouda), plus four to six dried apricot halves.
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