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More Biotech Twitter Mailbag: Orexigen, Affymax, YM Bio, Spectrum & More
The last third of anemia drug sales comes from small- and mid-sized, independent dialysis clinics. These guys don't get the sweetheart Epogen discounts from Amgen that Davita and Fresenius enjoy today so they're probably most open (and eager) for competition. Let's say Affymax can win a third of this bucket, or $200 million.
Peginesatide sales of $330 million at the end of 2015, of which Affymax receives half, risk adjusted at 90% given the looming approval decision, discounted back by 20%, yields a net present value of $73.7 million. Apply a five-times-sales multiple and you get an Affymax enterprise value of $368 million.
Please don't take these numbers to the bank but you get the idea.
Risks to the Affymax story: Amgen is an entrenched competitor that may be more difficult than anticipated to beat. Affymax and Takeda will operate the peginesatide business through a 50-50 joint venture; I generally don't like these setups because the smaller partner (Affymax) is at a disadvantage i.e. Onyx Pharma in its Nexavar joint venture with Bayer.@HemPaddy: "Why is YMI so low profile even after showing GREAT results - Street is not buying YMI story?" Referring to YM BioSciences (YMI) as "low profile" sounds like a polite euphemism for unloved? Ignored? Distrusted? You ask a great question; unfortunately, I don't have a definitive answer. YM Bio shares at $2 have barely nudged higher since the presentation last December of strong phase II data on its myelofibrosis drug CYT387. [The '387 data, particularly the positive anemia response, were strong, right? I thought so.] When I ask buyside investors about why YM Bio seems so unloved, I get responses like these: We don't believe the anemia response data. We don't trust management given YM's poor track record. Why hasn't YM Bio been able to land a partner for '387? The company's recent financing was too dilutive. The company won't be able to enroll patients in its planned phase III study because Incyte's (INCY) Jakafi is already on the market. Who cares about a second-to-market myelofibrosis pill? Some of these concerns are silly, others more reasonable but still defensible. Whether you're a true believer in YMI and '387 or not, the valuation gap between the company and Incyte is too large to ignore. I'm not sure if or when sentiment shifts.
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Classes & Registration
The Spruill Center offers day, evening, and weekend courses for Adults, Teens, and Children. Please feel free to browse our listings across all of our departments, including: Jewelry, Ceramics, Drawing, Painting, Mixed Media, Sculpture, Decorative Arts, and more!
Click on the Major Category (Adult, Children, Teens, etc) and then the department of interest to you. There you will find a list of courses with their dates and times. Click on the course title to continue the registration process. Every child and adult must have an account to register. Family members may use the same e-mail address; however, a unique password is required for each member of the family. If you have any questions, do not hesitate to contact The Registration Office at 770.394.3447 x 0. Thank you for visiting our registration page. We look forward to seeing you soon!
Download Our Paper Catalog
Browse Courses
- Browse complete
course listings
- Adult Courses and workshops
- Special Workshops
- Children & Teens
- Children's Camps
Additional Information
Four easy ways to register for courses:
Create an Account
(First-time students only)
(Returning Students/Members)
By mail
Download/print/complete the printable registration forms of your choice:Registration Form
Camp Form
... and then mail it to:
Spruill Center for the Arts
5339 Chamblee Dunwoody Rd
Atlanta, GA 30338
By Fax
Download/print/complete the printable registration forms of your choice:Registration Form
Camp Form
... and then fax it to:
(770) 394-6179
Download/print/complete the printable registration forms of your choice:Registration Form
Camp Form
... and then bring it by:
Spruill Center for the Arts
5339 Chamblee Dunwoody Rd
Atlanta, GA 30338
FAQ & Policies
Spruill Center Registration Office:
Monday through Thursday 9:00am - 7:00pm
Friday 9:00am - 5:00pm
Most Saturdays 9:00are -12:00noon
Spruill Gallery Hours, call 770.394.4019
The Spruill Center offers day, evening, and weekend classes for Adults, Teens, and Children in a wide variety of visual art media. Browse listings across all of our departments, including: Jewelry, Ceramics, Drawing, Painting, Mixed Media, Sculpture, Decorative Arts, and more. Click on the major listing and the department to view our offerings and see what classes are currently available. Browse Online Catalog
All classes are held at the Spruill Education Center unless otherwise stated or notified by the registration office. In the event that a course is held off-site, directions will be provided. For room location, check posted room use lists located at the entrances of the Education Center at the time of class.
Our instructors are professional artists, teachers and college professors. They are carefully chosen for their artistic talent and their ability to successfully communicate skills, techniques, and processes to students.
Regular course and special workshop instructors are independent contractors. As such, they design their own course curriculum and can generally answer more in depth questions about their classes. Most instructors have contact information available for their students. Please contact the Registration Office at 770.394.3447 x 0 for more information. You can also visit the Classes area of our website to view the Instructor Bios section.
Summer Camp Instructors are SCA and are drawn from the public & private school systems. They are subject to a background check at the state and federal levels.
You can register using the online registration system or complete a paper registration form with payment. The paper form can be faxed, mailed, or dropped off at The Education Center. The registration form can be found in the paper catalog, using the links on the registration page of our website, or at the registration desk outside of room 19 at The Education Center. Spaces will not be held without a registration form and/or payment.
- Look Up Course by navigating through our Course Listing page.
- Click on the "Enroll Yourself" button on the Course Information page.
- Log in to the system. If you are already logged in, this step will be skipped.
- Select the course fee options. If you have a valid membership, select the member rate. If your membership is not active the member rate will not be listed. The donation is optional. Uncheck this box if you choose not to contribute to program costs.
- Click on "Finish Registration"
- Read the release of all claims. You must click Agreed to continue your registration. It is required to attend any of our courses.
- To add more courses click "Cancel" or "Add More Courses" from the Enrollment Card page.
- Once all desired classes have been added, click "Finish Registration".
- Click "Submit" to begin the online payment process.
- Complete the payment information on the payment form. Be sure that the card information is correct and the billing address is the same as it appears on your credit card billing statement.
- Click Submit
- Once the registration is complete a button will appear "Click to Complete." Click on this button.
- Confirmation - the Registration Confirmation page will provide notification of enrollment. A confirmation e-mail including the course date, time, and payment information will be sent to you via e-mail. At this time, you can safely log out of the system.
The temporary password for existing students who have not previously used the registration form is as follows: first initial (lowercase), last initial (lowercase), zip code. For Example Sally Spruill living in zip code 30338 would be ss30338. Once you have successfully logged in, you will be prompted to change your password immediately. If you have forgotten your password, the Registration Office staff can reset it for you. Please note: Spruill Center staff cannot view your password. You can also reset your password by clicking on "Forgot Password." The same e-mail address can be used for multiple students as long as the password for each student account is unique.
To see a list of your course registrations, go to My History section.
Visa, Master Card, Discover, Cash, or Check. We do not accept American Express.
We do have any scholarships available in our ceramics department and there are a limited number of scholarships available for our summer camp program. Please contact our Education Director at 770.394.3447, extension 229.
The membership discount is $20 for all classes that are greater than $100. For classes $100 or less the membership discount will range from $10-$15, depending on the cost of the course.
To pay for membership online, select the membership level and click continue. You may add course registrations in addition to your membership. The member fee will be reflected in your total on the payment page. You may also print, complete, then e-mail or fax a membership form. Household members names must be called in to the Registration Office at 770.394.3447 x 0.
The Spruill Center reserves the right to refuse/cancel registration, change or cancel any class for any reason. Students will be notified in All class cancellations, changes and refunds initiated by a student must comply with following time lines:
COURSE CHANGES and CANCELLATIONS
- Changes/cancellations initiated by a student will incur an administrative fee and MUST be accepted by an SCA employee 3 business days
(M-F 9 to 5) before class.
- Administrative Fees range from $10-$20, based on the cost of the course.
- The Spruill Center reserves the right to refuse/cancel registration, change or cancel any class for any reason.
- Students will be notified in the event of a course changed or cancelled by SCA as soon as possible.
- No refunds, transfers, and cancellations after a course has begun or beyond the registration deadline.
- Emergency/Medical refunds may be available at the discretion of The Registrar with documentation.
- Memberships and donations are NOT REFUNDABLE.
- Monies will not be held as a credit for future use.
- Previously retained fees will not be refunded.
- Summer Camps changes/cancellations must be confirmed by an SCA employee at least two (2) weeks prior to the start of the camp session for which your child is enrolled.
- Deposits are not refundable under any circumstances. If there is no deposit, the deposit will be considered as $100 of the total.
- Emergency/Medical refunds do not apply to deposits.
- The administrative fee for special workshop cancellations before the two week deadline is 15% of the total amount paid over and above the deposit.
- No refunds, transfers, and cancellations after a published registration deadline/ balance due date, and/or no later than two weeks prior to the first day of the workshop.

subset: commoncrawl


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This post is also available in: Italian, Russian
This resort is situated in the heart of Patong Beach, close to all major attractions. However, our guests will find privacy and peaceful atmosphere which won't be disturbed. Baan Laimai Resort is only fifty meters from the white sands of Patong Beach and the sparkling Andaman Sea. In immediate proximity to the hotel there are also many Thai restaurants, famous networks as McDonald's and Starbucks, shops, night clubs, pubs and an. You will love our large outdoor pool which is a nice quiet place to relax and meet other travelers. Baan Lamai Beach Resort is absolutely perfect choice for families, couples and honeymooners looking for an unforgettable vacation.
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Beach Lovers Retreat in Fort Myers Beach
- bedrooms 1
- baths 1
- sleeps 4
- pool yes
- hot tub no
- pets allowed yes
- type Apartment
- community "Quiet Area"
rates (USD)
/ week
$ 2,195 - $ 3,629 / month
vacation rental description
This is a beach lover's dream. This 1 bedroom 1 bath is centrally
located and super convenient to the beach! You can fish in the
canal in back or even dock a boat. There is a spacious deck and
screened in porch area.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 06-30-2014 at 8:53 AM.
email owner view full calendar
Debra Salyers
apartment rental amenities
Pool and deck on canal
Screen lanai
Beach Access 1 block
Laundromat 1 block away
full kitchen
t.v.'s/ DVD
activities and attractions in Fort Myers Beach Gulf Coast South
-Casino Boats
-Dog races
vacation rental rates
$959 per week December 15 - May 1
$695 per week May 1 - December 15
$200 deposit held to reserve and until departure, $500. for monthly rentals
All rates are inclusive of everything but tax!!!!!! Bring your boat, pets, etc.!
2015 Rentals
Jan. '15- $2,195. Feb. '15- $3,495.. Mar. '15- $3,295.
Debra Salyers
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center


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1. The Womanly Art of Breastfeeding
This book has been a classic for decades. Now it is updated in 2010 for the modern breastfeeding mother with wisdom passed down from woman to woman - through the ages. It is written and produced by La Leche League. This book was also the winner of the 2012 Reader's Choice Award for Best Baby Shower Gift.
2. The Nursing Mother's Companion
3. Breastfeeding Made Simple
4. Breastfeeding with Confidence
5. The Ultimate Breastfeeding Book of Answers
Written by Dr. Jack Newman, pediatrician and breastfeeding expert, this book is a wealth of information. It's got a very conversational style and gives lots of practical advice with his professional experience and observations liberally spread throughout. It really can provide the reader with a sense that you are not alone.
6. The Breastfeeding Book
Martha Sears, mother, nurse and lactation counselor writes this book in the friendly prose of the typical Dr. Sears book. The illustrations are simple and the text matches nicely. The chapters are laid out well and it does include information on some common problems as well as information on returning to work and using a breast pump.


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High School Musical
High School Scholarships
The PYP Talent Show-Centerstage 2013
Concordian International School promotes academic excellence while nurturing young people to become moral and intellectual leaders, people of dignity, integrity and compassion, who want to make a difference in the world.
The Life Skills Program is a 3-month dormitory residence program that provides excellent opportunities for students to build an essential ……
Young Leaders Project Lotus Shanghai Internship 2013 By Passachon (Naam) Srisaard G11 SHANGHAI, CHINA – The CP Lotus Internship took ……
Program of Soft Opening Ceremony of Grand Theater, 4th floor of High School Building, Thursday, 9th May, 2013 Opening Ceremony ……
Thailand's IB English Chinese International School
918 Moo 8, Tambon Bangkaew, Amphur Bangplee, Samutprakarn
Thailand 10540
Tel. +(662) 706-9000, Fax. +(662) 706-9001
E-mail : firstname.lastname@example.com
Copyright©2011 Concordian International School. All rights reserved
football shirt


text:
The Economic Report of the President came out yesterday. (I was too busy digging out to notice.) I'll have more to say on it over the weekend, but if you check out Chapter 5, "Addressing the Long-Run Fiscal Challenge," you'll see the Council of Economic Advisers was very careful to stick to script on tax policy in the following ways:
More later this weekend in between more digging out!
Guest Bloggers are not employed or directed by The Christian Science Monitor and the views expressed are the blogger's own. Submissions are neither edited nor reviewed before they appear on CSMonitor.com. If you have any comments about a blogger, please contact us. To comment on this post, please go to the blogger's site by clicking on the link above.


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Book Review: "The Orenda," by Joseph Boyden
Jan 08, 2014 — What was life like for the first French Jesuits, men who rode in canoes up the St. Lawrence River to live with the Iroquois and the Huron? In Joseph Boyden's epic novel, The Orenda, Jesuit priests come to live with a community of Wendat-Huron people at a time of change and disaster.
Hear this
Explore this
Reported by
Betsy Kepes
Book Reviewer


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To DeWitt, where coach Rob Zimmerman and his panthers hosted Fowlerville in the CAAC red opener.
The fans were crazy for their football in Panther country.
And Zimmerman is an offensive genius with an all-world quarterback. Jacob Johnson aired it out to Joshua Borta. He hauled in one of his seven catches, and one of his two touchdowns. Johnson threw 5 touchdown passes and 208 yards thru the air. Zimmerman loved the execution of the plays.
Near the goal line, Nate Trevino went in motion and into the endzone with the pigskin, for a 28-0 Panther lead.
They rolled 55-0, DeWitt now 3-0.


text: A small web-framework. Or rather, less a web "framework", and more some helper classes around Ruby CGI. This is an INOFFICIAL release of Cyberweb, Version 0.0.5. It is still rather unfinished and incomplete, but it works ok-ish for my own needs. To include this project on a website, do this: require 'cyberweb/autoinclude'


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New Music: Slaughterhouse f/ Eminem – 'Throw That'
Slim Shady comes out to play on "Throw That," the latest release from Slaughterhouse's upcoming album welcome to: OUR HOUSE (Aug. 28). The Shady characters get into some freaky escapades involving strippers and handcuffs on the T-Minus production, while Eminem delivers some not-so-chivalrous pick-up lines ("I'll throw this d**k on you, girl"). How romantic.
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(08/19/12) - Nearly one year ago, the son of a Flint couple was arrested in Iran.
Since then, family and friends have been fighting for the safe release of Amir Hekmati.
Now, they're asking you to help as well.
Lending a helping hand is Matthew Packer, Mott Community College's choral director.
Packer became involved after attending another fundraiser for a co-worker's son.
Amir Hekmati is the son of a Mott professor.
"Aug. 29 will be a year. It's been a year since he's been gone. And it's not just a year of time he's been away at college, or a year he's been away somewhere else. It's a year he's been in prison, overseas," said family member, Bilal Kurdi.
In August of 2011, Hekmati's family said the former Marine went to Iran to visit his grandmothers.
His two week trip has now turned into a year. Hekmati was arrested and put in prison. The Iranians accuse him of being a CIA spy.
"It's a hardship that is already hard to carry on its own. And it's a hardship that's even harder with no news," Kurdi said.
In his first trial, Hekmati was sentenced to death. That sentence has since been overturned.
His family and friends are praying for a retrial. They say it's now a waiting game. "The latest is actually pretty much status quo. Right now we're waiting," Kurdi said.
As they wait, they're working hard.
On Saturday, Aug. 25, they're hosting a benefit concert for Hekmati.
That's the same day as another big event in Flint. "We actually have performers that are running in the Crim in the morning, then coming to do the concert in the evening, which is great," Packer said.
Money raised will help pay for Amir's defense. "The bills rise quickly with this kind of thing. It's not your average type of defense, so ultimately it's the generosity of the Flint community," Kurdi said.
The concert begins at 7 p.m. at the University of Michigan Flint Theater.
"The main thing is this, they didn't just want to collect money, they want to give something back to the community," Kurdi said.
Click here to go to a website with more information.
ABC12 Main Station810-233-3130
Mailing Address:2302 Lapeer RoadFlint, Michigan 48503


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i work at new york magazine & vulture.com
but i want them all
Nicest write up EVARR. Thanks, Nicole!!!!
I can't get over this.
o fuq
This is important nail news.


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COLONIE, N.Y. -- The Colonie town supervisor and attorney say new violations have been filed against Colonie motel owner Alex Patel.
Two of Patel's properties, the Skylane Motel and Blu Bell Motel, were shut down after violations such as holes in the floors and no running water.
Town Attorney Mike Maguilli said a search warrant was served at the Blu Bell after he drove by the motel and noticed workers doing repairs, later discovering they didn't have a permit.
Patel has already been cited with 299 code violations at Skylane, and he now faces 418 violations for the Blu Bell location.
Officials said Patel was making money off the county by housing homeless, displaced families, and some sex offenders. Patel owns the Blu Bell Motel, Super 8, and a Golden Corral but the county said they have not placed anyone at the Blu Bell location in years.
Those who were living at the motel were paying $800 a month to live at the Blu Bell Motel. However, conditions were poor, which cracked windows, rooms without heat, and holes in some of the bathroom floors.
One of those residents, Diane, said she had nowhere else to go, which was something management used to their advantage.
Maguilli said none of the former residents will be left out in the cold after the motel shutdown Tuesday.
Patel's Attorney Dreyer Boyajian did not return phone calls to NEWS10 ABC for comment.
The county inspector who gave a passing inspection to the Skylane Motel was suspended in late January.
Now, he is facing further charges. Anya Tucker will have a full report on NEWS10 ABC.
Find violation information on Skylane and Blu Bell below the comments section on this page.


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This course develops students' skills in common legal writing formats other than memos and briefs. Not intended as a remedial course, this course rather provides an opportunity for students to sharpen legal writing skills with an emphasis on clarity and precision of expression. Weekly writing assignments include a few fully drafted documents (e.g., a short will, a short contract, a statute), as well as letters, short pleadings, jury instructions, and other short pieces. Students will concentrate on re-writing and editing their work.
CORE 912 and CORE 914 Legal Research and Writing I and II


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November 22, 2003
Albany- Author Mary Sterner Lawson held a book signing at June Bug's Grocery. Her book, June Bug's Grocery and the Cornfield Jook, is an oral history of South Albany during the forties and the fifties.
The book is a compilation of interviews given by 60 Albanians and it's cover is a reproduction of a painting by Lawson of the original store.
"It gives the history of the community and a sense of the comradery and brotherhood, and it gives a sense of what life was like in South Albany starting when it was more rural in the 40's and 50's on in to when it was more connected with Albany," Lawson says.
The book is on sale at June Bug's and will be sold in several area book stores.
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(229) 446-1010
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text:
POST FALLS, Idaho - My Funny Valentine is an evening taking a comical (and musical!) look at love in all its stages, from First Sight to Marriage!
Featuring Karen and Daniel J. Bell, Eric McGaughey and Becca Sims, Lance Babbitt, Hannah Paton, Steve Kane, and Teri DeCorte Grubbs. Accompanist Zachariah Baker, Emcee Jett Bingman, Director Heath Bingman.
Raffle Items Include… 2 tickets to WIT performed at Lakecity Playhouse, 2 tickets to the Academy Awards Night by CST, and 1 Tray of Goodies from Pastry & More.
For more information, visit their website here: http://www.thejacklincenter.org/index.html
SPOKANE, Wash. - Pig Out In The Park brings in thousands to delve into their favorite fair-like foods and put diets on the back burner. But this year is a little bit different, because organizers are calling it the largest pig out yet.


text:
G.W. Bush visits downtown San Diego, promotes memoir
Former President George W. Bush is scheduled to address members of the San Diego Regional Chamber of Commerce on Thursday in a fitting location — the Presidential Ballroom at the U.S. Grant Hotel.
Bush is expected to share his experiences during his presidency, including the Sept. 11, 2001, terrorism attacks, Hurricane Katrina and the war in Iraq.
Bush is on a speaking tour coinciding with the release of his memoir, "Decision Points." Work also began this week on the George W. Bush Presidential Library at Southern Methodist University in Dallas.
Related posts:
- SDG&E's plans to develop solar facilities approved
- County agencies approved for federal subsidies for early retirees
- Assembly unanimously approves Chelsea's Law
- Jerry Brown scheduled to tour San Diego biodiesel company today
- State Senate approves Chelsea's Law
Short URL: http://www.lajollalight.com/?p=6532


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Saturday, June 19, 2010
2 comments:
I recently retried my hand at drawing. I don't do it often and this was more an exercise of catharsis than anything. 2 of the pieces I drew were pretty okay. 1 was a self portrait of me as a 1 legged chicken with a vodka bottle for a beak and the other was a picture of my soul trapped in a vodka bottle.ReplyDelete
Sad stuff, but it is all I could do at the moment. It helped though.
Hi, sorry for my late reply.ReplyDelete
Some times my hand just draws what I have in my heart ... I was never good at sketching and for sure I will never be, but having the ability to illustrate my feelings - good or bad - it's always helpful for myself and very inspiring.
Lately I'm doing more and more quick sketches and such, and then I finish them digitally. The result satisfies me, even more when I can still see my scrap in the finished work.
Keep creating Teddy ;)
Hope you well.


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Firefighters in Glendale rescued a maintenance worker who fell into a sewer Thursday morning.
The man plunged about 30 feet this morning into the waste at an apartment complex near 75th and Glendale Avenues.
Firefighters say he was cleaning the screen on the sewer hole when he fell in.
As he started to climb out, he was overcome by the fumes and fell back in.
He was nearly all the way out by the time rescuers got there. He didn't suffer any serious injuries.
Authorities say the man was wearing improper gear for the job.
KTBC FOX 7119 East 10th StreetAustin, TX 78701Phone: (512) 476-7777Fax: (512) 495-7001