text:
Research Topics
Genomes and Genes
Summary: A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications224 found, 100 shown here
- The molecular regulation of myogenesisL A Sabourin
Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
Clin Genet 57:16-25. 2000..studies have unraveled important mechanisms by which the four myogenic regulatory factors (MRFs: MyoD, Myf-5, myogenin, and MRF4) control the specification and the differentiation of the muscle lineage...
- Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expressionHervé Faralli
Institut de Biologie du Developpement de Marseille Luminy, UMR 6216, CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
J Biol Chem 286:23498-510. 2011..we showed that overexpression of Tshz3 impaired myogenic differentiation and promoted the down-regulation of myogenin (Myog) and up-regulation of paired-box factor 7 (Pax7)...
- Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4M R Valdez
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
Dev Biol 219:287-98. 2000The basic helix-loop-helix (bHLH) transcription factors-MyoD, Myf5, myogenin, and MRF4-can each activate the skeletal muscle-differentiation program in transfection assays...
- Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding siteF Spitz
Institut National de la Santé et de la Recherche Médicale U129, Institut Cochin de Genetique Moleculaire, Universite Rene Descartes Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
Proc Natl Acad Sci U S A 95:14220-5. 1998b>Myogenin, one of the MyoD family of proteins, is expressed early during somitogenesis and is required for myoblast fusion in vivo...
- Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligasesViviana Moresi
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell 143:35-45. 2010..We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy...
- Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding siteW E Wright
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical School, Dallas 75235
Mol Cell Biol 11:4104-10. 1991The consensus binding site for the muscle regulatory factor myogenin was determined from an unbiased set of degenerate oligonucleotides using CASTing (cyclic amplification and selection of targets)...
- The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoterRamkumar Sambasivan
Centre for Cellular and Molecular Biology, Hyderabad, 500 007 India
J Cell Sci 122:3481-91. 2009..We show that, similar to MyoD and p300, p8 and p68 are located at the myogenin promoter, and that knockdown of p8 compromises chromatin association of all four proteins...
- MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growthP Steinbacher
Division of Zoology and Functional Anatomy, Department of Organismic Biology, University of Salzburg, Salzburg, Austria
Dev Dyn 236:1106-14. 2007..Here, we use molecular techniques to provide a comprehensive characterization of MyoD and Myogenin expression during myogenic cell activation in embryos and larvae of brown trout, a fast-growing salmonid with ..
- The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expressionYu Oikawa
Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
Cell Res 21:1578-90. 2011..of skeletal muscle are carried out mainly by satellite cells, which, upon stimulation, begin to express myogenin (Myog), the critical determinant of myogenic differentiation...
- Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humansThue Kvorning
Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
J Physiol 578:579-93. 2007..05). mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0...
- A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation programD G Edmondson
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Genes Dev 3:628-40. 1989..Together, these results suggest the existence of a family of myogenic regulatory genes that share a conserved motif with c-myc...
- Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscleArif Aziz
Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, CA
Epigenetics 5:691-5. 2010..Thus Mef2d, Six4, and p38α MAPK function coordinately as regulators of a master regulator to mediate expression of MyoD target genes...
- Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiationXiaobing Deng
Departments of Pathology and Cell and Developmental Biology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
J Biol Chem 278:41347-54. 2003..Mirk was induced with similar kinetics to another Rho-induced differentiation gene, myogenin. Mirk protein levels increased 10-fold within 24-48 h after primary cultured muscle cells; C2C12 mouse myoblasts ..
- MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouseE M Füchtbauer
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
Dev Dyn 193:34-9. 1992..Little is known about the presence of MyoD1 and myogenin during the process of regeneration...
- Myogenin and MyoD1 expression in paediatric rhabdomyosarcomasN J Sebire
Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London GU21 2FB, UK
J Clin Pathol 56:412-6. 2003..This review examines the use of the immunohistochemical markers, MyoD1 and myogenin, in the diagnosis of paediatric rhabdomyosarcoma, including its subtypes.
- Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cellsZhao Yong Li
National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
J Biol Chem 282:18872-8. 2007b>Myogenin and its upstream regulator MyoD are known to be required for myogenic cell differentiation...
- Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiationXiaobing Deng
Department of Pathology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
J Biol Chem 280:4894-905. 2005..We now demonstrate that knockdown of Mirk blocks transcription of the muscle regulatory factor myogenin. Co-expression of Mirk with MEF2C, but not MyoD or Myf5, enhanced activation of the myogenin promoter in a Mirk ..
- Muscle differentiation. Which myogenic factors make muscle?M Buckingham
Department of Molecular Biology, Pasteur Institute, CNRS ERS 67, Paris, France
Curr Biol 4:61-3. 1994Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.
- An initial blueprint for myogenic differentiationAlexandre Blais
Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 19:553-69. 2005..We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2 (MEF2)...
- Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2Shi Wen Luo
Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
EMBO J 28:2568-82. 2009..chromatin remodelling by its interaction with MBD2 (methyl CpG-binding protein 2), underlying FAK regulation of myogenin expression and muscle differentiation...
- Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin geneP Hasty
Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
Nature 364:501-6. 1993b>Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated...
- MyoD, myogenin independent differentiation of primordial myoblasts in mouse somitesM G Cusella-De Angelis
Institute of Histology and Embryology, University of Rome La Sapienza, Italy
J Cell Biol 116:1243-55. 1992The accumulation of two myogenic regulatory proteins, MyoD and myogenin, was investigated by double-immunocytochemistry and correlated with myosin heavy chain expression in different classes of myoblasts in culture and during early ..
- Regulation of skeletal muscle differentiation in fibroblasts by exogenous MyoD gene in vitro and in vivoRui Feng Qin
Department of Oral Maxillofacial Surgery, Qin Du Stomatological College, Fourth Military Medical University, Xian, P R China
Mol Cell Biochem 302:233-9. 2007..RT-PCR and immunohistochemistry confirmed the increased expression of characteristic downstream molecule myogenin and mysion heavy chains during myogenic differentiation...
- RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiationDonghao Jin
Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
Genes Cells 15:1158-67. 2010..b>Myogenin is a major player in the initiation and maintenance of myogenic differentiation in a mouse myoblast cell line, ..
- Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylationAndrea Fuso
Department of Surgery P Valdoni, Sapienza University of Rome, Italy
Cell Cycle 9:3965-76. 2010..In this work, we analyzed the DNA methylation pattern of the 5'-flanking of the myogenin gene, a positive regulator of muscle differentiation with no CpG island and low CpG density, in both C2C12 muscle ..
- MyoD and myogenin protein expression in skeletal muscles of senile ratsEduard I Dedkov
Department of Cell and Developmental Biology, 4643 Medical Sciences II Building, University of Michigan, Ann Arbor, Michigan 48109, USA
Cell Tissue Res 311:401-16. 2003We analyzed the level of protein expression of two myogenic regulatory factors (MRFs), MyoD and myogenin, in senile skeletal muscles and determined the cellular source of their production in young adult (4 months old), old (24, 26, and 28 ..
- The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cellsQ Xu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China
J Biol Chem 275:36750-7. 2000..One of the molecular mechanisms underlying IGF-stimulated myogenesis is transcriptional induction of myogenin. The current work is aimed to elucidate the signaling pathways mediating the IGF effect on myogenin promoter in ..
- A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscleLibera Berghella
Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park, Rome 00128, Italy
Genes Dev 22:2125-38. 2008b>Myogenin is the dominant transcriptional regulator of embryonic and fetal muscle differentiation and during maturation is profoundly down-regulated...
- Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87Chris S Blagden
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
Mol Cell Biol 24:1983-9. 2004..The binding of these bHLH proteins, notably MyoD and myogenin, to E-boxes in their own regulatory regions is blocked by protein kinase C (PKC)-mediated phosphorylation of a ..
- Myogenin induces higher oxidative capacity in pre-existing mouse muscle fibres after somatic DNA transferMerete Ekmark
Department of Biology, University of Oslo, PO Box 1051, Blindern, N 0316 Oslo, Norway
J Physiol 548:259-69. 2003..b>Myogenin is a muscle-specific, basic helix-loop-helix transcription factor that is important during early muscle ..
- The transcription of MyoD1 and myogenin genes in thymic cells in vivoM D Grounds
Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands
Exp Cell Res 198:357-61. 1992The skeletal muscle specific genes MyoD1 and myogenin are closely associated with commitment of cells to the myogenic lineage and differentiation of skeletal muscle precursor cells...
- Insulin-like growth factor-mediated muscle differentiation: collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogeninJ Tureckova
Oregon Health and Science University, Molecular Medicine Division, Department of Medicine, Portland, Oregon 97201-3098, USA
J Biol Chem 276:39264-70. 2001..Here we use this cell line to identify signaling pathways controlling IGF-mediated differentiation. Induction of myogenin by IGF-I and myotube formation were prevented by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, even ..
- Myogenin is required for late but not early aspects of myogenesis during mouse developmentJ M Venuti
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
J Cell Biol 128:563-76. 1995Mice with a targeted mutation in the myogenic basic helix-loop-helix regulatory protein myogenin have severe muscle defects resulting in perinatal death...
- SMYD1, the myogenic activator, is a direct target of serum response factor and myogeninDali Li
The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241
Nucleic Acids Res 37:7059-71. 2009..and characterized the human SMYD1 promoter, which contains highly conserved serum response factor (SRF) and myogenin binding sites...
- Myostatin negatively regulates satellite cell activation and self-renewalSeumas McCroskery
Animal Genomics, AgResearch, Hamilton 2015, New Zealand
J Cell Biol 162:1135-47. 2003..satellite cell number could be due to increased self-renewal and delayed expression of the differentiation gene (myogenin) in Mstn-/- adult myoblasts...
- Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimicsM H Cessna
Department of Pathology, University of Utah School of Medicine, Salt Lake City, USA
Am J Surg Pathol 25:1150-7. 2001..Immunohistochemistry is used extensively to distinguish RMS from its mimics. Myogenin and MyoD1, myogenic transcriptional regulatory proteins expressed early in skeletal muscle differentiation, are ..
- Interplay between DNA methylation and transcription factor availability: implications for developmental activation of the mouse Myogenin geneDaniela Palacios
Section of Gene Function and Regulation, Institute of Cancer Research, London, United Kingdom
Mol Cell Biol 30:3805-15. 2010..Using the mouse Myogenin promoter as an example of the weak CpG island class of promoters, we find that it is initially methylated but ..
- p53-independent expression of p21Cip1 in muscle and other terminally differentiating cellsS B Parker
Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
Science 267:1024-7. 1995..p21 expression in 10T1/2 cells, p21 was expressed in myogenic cells of mice lacking the genes encoding MyoD and myogenin, demonstrating that p21 expression does not require these transcription factors...
- Effects of interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor on the proliferation and differentiation of adult human myoblastsXuan Wang
Department of Physiology, Capital Medical University, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, 10 You An Men, Fengtai District, Beijing, 100069, P R China
Cell Mol Neurobiol 28:113-24. 2008..This study will provide the experimental and theoretic foundations for the basic and clinical researches about human myoblasts...
- MyoD synergizes with the E-protein HEB beta to induce myogenic differentiationMaura H Parker
Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
Mol Cell Biol 26:5771-83. 2006..Upon induction of differentiation, a MyoD-HEB beta complex bound the E1 E-box of the myogenin promoter leading to transcriptional activation...
- Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body sizeJennifer R Knapp
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Development 133:601-10. 2006..Here, we test this assumption by determining the role of the myogenic regulator myogenin in postnatal life...
- MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficientD D Cornelison
Biology Division 156 29, California Institute of Technology, Pasadena 91125, USA
Dev Biol 224:122-37. 2000..upregulate MRF4, displayed a major deficit in m-cadherin expression, and showed a significant diminution in myogenin-positive status compared with wildtype...
- Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiationStephane Konig
Departement de Physiologie, Centre Medical Universitaire, Hopital Cantonal Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
J Biol Chem 279:28187-96. 2004It is widely thought that myogenin is one of the earliest detectable markers of skeletal muscle differentiation. Here we show that, during human myoblast differentiation, an inward rectifier K(+) channel (Kir2...
- Myogenin regulates a distinct genetic program in adult muscle stem cellsEric Meadows
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Dev Biol 322:406-14. 2008..The purpose of this study was to determine the role that the myogenic basic helix-loop-helix regulatory factor myogenin has in postnatal muscle growth and adult muscle stem cell gene expression...
- Expression of MyoD and myogenin in dystrophic mice, mdx and dy, during regenerationY Jin
Department of Ultrastructural Research, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
Acta Neuropathol 99:619-27. 2000Expression of two myogenic regulatory factors, MyoD and myogenin, was studied in regenerating muscles of dystrophic mice and compared to a chemically induced regeneration process...
- Myogenin regulates denervation-dependent muscle atrophy in mouse soleus musclePeter C D Macpherson
Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Cell Biochem 112:2149-59. 2011..Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle-specific transcription factor that is highly induced following muscle denervation...
- The effects of age and hindlimb supension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal musclesS E Alway
Division of Exercise Physiology, Robert C Byrd Health Science Center, West Virginia School of Medicine, Morgantown, WV 26506 9227, USA
Exp Physiol 86:509-17. 2001..Plantaris muscles from young adult rats had significantly higher levels of myogenin mRNA and protein (890 % and 314 %, respectively, P < 0...
- Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogeninH Li
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Cell Biol 124:827-41. 1994..inhibition of desmin expression was followed by differential inhibition of the myogenic regulators myoD and/or myogenin, depending on the stage and extent of desmin inhibition in these cells...
- Myogenin and oxidative enzyme gene expression levels are elevated in rat soleus muscles after endurance trainingParco M Siu
Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown WV 26506 9227, USA
J Appl Physiol (1985) 97:277-85. 2004..whether endurance exercise training regulates increases in metabolic enzymes, which parallel modulations of myogenin and MyoD in skeletal muscle of rats...
- Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycleB G Novitch
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biol 135:441-56. 1996..muscle differentiation program characterized by normal expression of early differentiation markers such as myogenin and p21, but attenuated expression of late differentiation markers such as myosin heavy chain (MHC)...
- Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma: a tissue microarray study of 71 primary tumors including correlation with molecular phenotypeAmy Heerema-McKenney
Department of Pathology parallelBiochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Surg Pathol 32:1513-22. 2008..containing 71 paraffin-embedded pediatric RMSs was immunostained with antibodies against p53, bcl-2, Ki-67, CD44, myogenin, and MyoD1...
- Myogenic factors that regulate expression of muscle-specific microRNAsPrakash K Rao
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 103:8721-6. 2006..By using CHIP analysis, we demonstrate that the myogenic factors Myogenin and MyoD bind to regions upstream of these microRNAs and, therefore, are likely to regulate their expression...
- Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesisAnne Sophie Armand
The Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CT Utrecht, The Netherlands
J Biol Chem 283:29004-10. 2008..The myogenic basic helix-loop-helix transcription factors, MyoD, myogenin, Myf5, and MRF4 specify the myogenic lineage...
- Myogenin gene disruption results in perinatal lethality because of severe muscle defectY Nabeshima
Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
Nature 364:532-5. 1993b>Myogenin is a member of the basic helix-loop-helix (bHLH) gene family and converts multipotential mesodermal cells to myoblasts...
- The regulation of myogenin gene expression during the embryonic development of the mouseS P Yee
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK
Genes Dev 7:1277-89. 1993..minimal sequences required for the complete recapitulation of the temporal and spatial expression pattern of the myogenin gene during embryogenesis...
- Decreased Jun-D and myogenin expression in muscle wasting of human cachexiaSonia Ramamoorthy
Department of Surgery, University of California San Diego, San Diego, California, USA
Am J Physiol Endocrinol Metab 297:E392-401. 2009..model of muscle wasting, TNF-alpha induces oxidative stress and nitric oxide synthase-2 (NOS2) and decreases myogenin, Jun-D, and creatinine kinase muscle isoform (CKM) expression...
- Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscleJudith K Davie
Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Dev Biol 311:650-64. 2007The myogenic regulatory factors MyoD and myogenin are crucial for skeletal muscle development. Despite their importance, the mechanisms by which these factors selectively regulate different target genes are unclear...
- Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligaseMisako Jogo
Department of Biology, Graduate School of Science, Chiba University, Inage Ku, Chiba, Japan
FEBS Lett 583:2715-9. 2009Myogenesis is conducted by transcription factors including MyoD and myogenin. Myogenin is known to be polyubiquitinated by SCF (Skp1/Cullin 1/F-box protein) followed by proteasomal degradation, though the participating F-box protein is ..
- Myogenin and desmin immunohistochemistry in the assessment of post-chemotherapy genitourinary embryonal rhabdomyosarcoma: prognostic and management implicationsP Godbole
Department of Paediatric Urology, Great Ormond Street Hospital for Children, London, United Kingdom
J Urol 176:1751-4. 2006..However, the recent use of immunohistochemical staining with desmin and myogenin in resected specimens and surveillance biopsies following adjuvant therapy may demonstrate scant positive ..
- Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary menMona Lindström
Section for Anatomy, Department of Integrative Medical Biology, Umea University, 90187 Umea, Sweden
Histochem Cell Biol 134:371-85. 2010..Our study unequivocally shows that staining for MyoD and myogenin are present in nuclei of SCs and of myoblasts and myotubes in areas of muscle fibre regeneration...
- Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1Francesc Vinals
Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, E 08907 L Hospitalet de Llobregat, Spain
J Biol Chem 279:45766-72. 2004..Here we describe that in C2C12 cells, BMP-2 decreases myogenin expression induced by des-(1,3) insulin-like growth factor-1 (des-(1,3)IGF-1) or ectopically expressed from a ..
- Induction of myogenin messenger ribonucleic acid in rat skeletal muscle after 1 hour of passive repetitive stretchingSatoshi Ikeda
Department of Rehabilitation and Physical Medicine, Faculty of Medicine, Kagoshima University, Japan
Arch Phys Med Rehabil 85:166-7. 2004To investigate the effect of repetitive passive stretch of living rat muscle on myogenin messenger ribonucleic acid (mRNA) expression.
- Effect of mechanical stretching on expressions of muscle specific transcription factors MyoD, Myf-5, myogenin and MRF4 in proliferated myoblastsS Abe
Department of Anatomy, Tokyo Dental College, Mihama ku, Chiba City, Chiba, Japan
Anat Histol Embryol 38:305-10. 2009..Myf-5 expressed only at early stage of the stretch group. Although mRNA and protein expressions of myogenin and MRF4 were detected both in the stretch and in the control group at 12 h after the stretching, their ..
- Interaction of the myogenic determination factor myogenin with E12 and a DNA target: mechanism and kineticsDaryl S Spinner
Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook 11794 5215, USA
J Mol Biol 317:431-45. 2002The myogenic determination factors MyoD, myogenin, myf5, and MRF4 are members of the basic helix-loop-helix (bHLH) family of transcription factors and crucial agents of myogenesis...
- A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppressionHuibin Tang
Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Mol Biol Cell 20:1120-31. 2009..Recently, it was reported that histone deacetylase 4 (HDAC4) can mediate denervation-induced myogenin and nicotinic acetylcholine receptor gene expression...
- Increased exchange rate of histone H1 on chromatin by exogenous myogenin expressionMing Gong
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
Cell Res 12:395-400. 2002..involved in the regulation of transcriptional activation of specific genes by a myogenic regulatory factor Myogenin, we used NIH3T3 fibroblasts with a stably integrated H1...
- Repetitive stretch induces c-fos and myogenin mRNA within several hours in skeletal muscle removed from ratsSatoshi Ikeda
Department of Rehabilitation and Physical Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
Arch Phys Med Rehabil 84:419-23. 2003..To investigate what effect repetitive stretch has on gene transcription in muscle tissues removed from rats...
- Opposing functions of ATF2 and Fos-like transcription factors in c-Jun-mediated myogenin expression and terminal differentiation of avian myoblastsL Daury
, , Institut National de la Recherche Agronomique (INRA, 2 place Viala, 34060 Montpellier Cedex 1, France
Oncogene 20:7998-8008. 2001..In addition, myogenin expression was a positive target of this cooperation and this regulation occurred through a stimulation of ..
- The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic developmentC H Biederer
University of California, San Francisco, School of Medicine, Cancer Research Institute, San Francisco, California 94143 0128, USA
J Biol Chem 275:26245-51. 2000..Promoter analyses demonstrate that the proximal E box element serves as a myogenin binding site and is both necessary and sufficient to control caveolin-3 gene transcription...
- Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculatureJ L Vivian
Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77050, USA
Dev Biol 224:29-41. 2000b>Myogenin and MRF4 are skeletal muscle-specific bHLH transcription factors critical for muscle development...
- Identification of MRF4: a new member of the muscle regulatory factor gene familyS J Rhodes
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907
Genes Dev 3:2050-61. 1989..a rat cDNA encoding MRF4, a new member of the muscle regulatory factor gene family that includes MyoD1, myogenin, and Myf-5...
- Myogenin, a factor regulating myogenesis, has a domain homologous to MyoDW E Wright
Department of Cell Biology and Anatomy, University of Texas Southwestern Medical Center, Dallas 75235
Cell 56:607-17. 1989..isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin. Transfection of myogenin into the mesenchymal cell line C3H10T1/2 produces cells expressing muscle-specific ..
- Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cellsD D Cornelison
Division of Biology, California Institute of Technology, Pasadena 91125, USA
Dev Biol 191:270-83. 1997..express either MyoD or myf5 first among the MRFs; most cells then expressed both myf-5 and MyoD simultaneously; myogenin came on later in cells expressing both MyoD and myf5; and many cells ultimately expressed all four MRFs ..
- Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1Gia Ming Hong
Environmental Toxicology Graduate Program, Department of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA
Toxicol Appl Pharmacol 260:250-9. 2012..that 20 nM sodium arsenite exposure to C2C12 mouse myocyte cells delayed myoblast differentiation due to reduced myogenin expression, the transcription factor that differentiates myoblasts into myotubes...
- Myogenin (Myf4) upregulation in trans-differentiating fibroblasts from a congenital myopathy with arrest of myogenesis and defects of myotube formationClaudia Weise
Department of Molecular Embryology, Institute of Anatomy and Cell Biology, Albert Ludwigs University Freiburg, Albertstrasse 17, 79104, Freiburg, Germany
Anat Embryol (Berl) 211:639-48. 2006..The abnormal upregulation of Myf4 and p21 in the patient who suffered from a severe congenital myopathy suggests that the regulation of Myf4 and p21 gene expression during myogenesis might be of interest for further studies...
- Sodium arsenite delays the differentiation of C2C12 mouse myoblast cells and alters methylation patterns on the transcription factor myogeninAmanda A Steffens
Environmental Toxicology Graduate Program, Clemson University, 132 Long Hall, Clemson, SC 29634, USA
Toxicol Appl Pharmacol 250:154-61. 2011..arsenite, allowed to differentiate into myotubes, and expression of the muscle-specific transcription factor myogenin, along with the expression of tropomyosin, suppressor of cytokine signaling 3 (Socs3), prostaglandin I2 synthesis ..
- p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin stepP Zhang
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
Genes Dev 13:213-24. 1999..point of arrest during muscle development is identical to that of mice lacking the myogenic transcription factor myogenin, indicating a role for cell-cycle exit in myogenin function...
- Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factorMónica Martínez-Moreno
Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, 28040, Madrid, Spain
J Biol Chem 282:23044-54. 2007..in caveolin-3 levels are due to the alteration of the DNA binding activity of the muscular transcription factor myogenin. In the presence of *NO, the binding of transcription factors from cell nuclear extracts of muscular tissues to ..
- Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1betaKlemen Strle
Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
Am J Physiol Endocrinol Metab 294:E709-18. 2008..role in nonhematopoietic cells by suppressing the ability of exogenous IL-1beta to inhibit IGF-I-induced myogenin and myosin heavy chain expression in myoblasts...
- Myostatin inhibits myoblast differentiation by down-regulating MyoD expressionBrett Langley
Animal Genomics, AgResearch, Private Bag 3123, East Street, Hamilton, New Zealand
J Biol Chem 277:49831-40. 2002..analysis indicated that addition of myostatin to the low serum culture media repressed the levels of MyoD, Myf5, myogenin, and p21 leading to the inhibition of myogenic differentiation...
- Influence of PDGF-BB on proliferation and transition through the MyoD-myogenin-MEF2A expression program during myogenesis in mouse C2 myoblastsZ Yablonka-Reuveni
Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
Growth Factors 15:1-27. 1997..We demonstrate that mononucleated C2 cells first express MyoD (MyoD+/myogenin- cells) and subsequently, myogenin...
- Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literatureD A Morgenstern
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
Pathol Oncol Res 14:233-8. 2008b>Myogenin immunostaining has been described as a useful marker of the alveolar subtype of rhabdomyosarcoma and as a tool for distinguishing it from the more common embryonal subtype...
- Absence of dysferlin alters myogenin expression and delays human muscle differentiation "in vitro"Noemi De Luna
Servei de Neurologia i Laboratori de Neurologia Experimental, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, 08025 Barcelona, Spain
J Biol Chem 281:17092-8. 2006..A luciferase reporter assay was performed to study myogenin activity in dysferlin-deficient cultures...
- Analysis of the DNA-binding properties of MyoD, myogenin, and E12 by fluorescence anisotropySoheila J Maleki
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205, USA
Biochemistry 41:10888-94. 2002MyoD and Myogenin are dominant myogenic regulatory factors (MRFs), which are involved in control of muscle-specific gene expression...
- Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinomaGladell P Paner
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 32:1022-8. 2008..All tumors showed immunohistochemical expression for desmin, myogenin, and/or MyoD1. Synaptophysin was performed in 4 cases, and 3 showed weak cytoplasmic immunoreactivity...
- Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivoA Myer
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Dev Biol 185:127-38. 1997..In mice lacking the bHLH transcription factor myogenin, myoblasts are specified and positioned correctly, but few fuse to form multinucleated fibers...
- Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylationNicki Tiffin
Department of Pediatrics, Box 0434, University of California San Francisco, San Francisco, California 94143 0434, USA
Endocrinology 145:4991-6. 2004IGF-I has a unique biphasic effect on skeletal muscle differentiation. Initially, IGF-I inhibits expression of myogenin, a skeletal muscle-specific regulatory factor essential for myogenesis...
- Inhibition of myogenin expression by activated Raf is not responsible for the block to avian myogenesisSally E Johnson
Department of Poultry Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 277:28742-8. 2002..We examined the effects of activated Raf on myogenin gene expression in avian myoblasts...
- Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4Patrizia Nanni
Section of Cancer Research, Department of Hematology and Oncological Sciences, University of Bologna, Bologna, Italy
Mol Cancer Ther 8:754-61. 2009..Terminal myogenesis is controlled by cell-intrinsic myogenic transcription factors like myogenin and environmental mediators like interleukin 4 (IL-4)...
- Induced expression of myoD, myogenin and desmin during myoblast differentiation in embryonic mouse tongue developmentA Yamane
Department of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Japan
Arch Oral Biol 43:407-16. 1998..myogenesis in embryonic mouse tongue through the induction of myogenic regulatory factors such as myoD, myf5, myogenin and MRF4/myf6/herculin...
- CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cellsXin Gao
National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Cell Biochem 110:162-70. 2010..Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation...
- Effect of genetic selection on MyoD and myogenin expression in turkeys with different growth ratesC Liu
Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA
Poult Sci 84:376-84. 2005..development requires the ordered expression of specific myogenic regulatory factors, which include MyoD, Myf5, myogenin, and MRF4...
- Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouseJesse M Flynn
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 5:e13535. 2010..The myogenic transcription factor myogenin is required for skeletal muscle development during embryonic and fetal life, but myogenin's role in adult ..
- Mammalian myotube dedifferentiation induced by newt regeneration extractC J McGann
Department of Internal Medicine, Division of Cardiology, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 98:13699-704. 2001..The muscle differentiation proteins MyoD, myogenin, and troponin T were reduced to undetectable levels in 15-30% of treated murine myotubes...
- Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2D G Edmondson
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Mol Cell Biol 12:3665-77. 1992..b>Myogenin, along with other members of the MyoD gene family, possesses the apparent ability to redirect nonmuscle cells ..
- p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expressionQing Xu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
Mol Biol Cell 13:1940-52. 2002In this report, we identify myogenin as an important transcriptional target under the control of three intracellular signaling pathways, namely, the p38 mitogen-activated protein kinase- (MAPK), calcium-calmodulin-dependent protein kinase-..
- Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant miceLina Kassar-Duchossoy
Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Nature 431:466-71. 2004..Gene targeting studies have revealed hierarchical relationships between these and the other MRF genes, Mrf4 and myogenin, where the latter are regarded as differentiation genes...
- Fine regulation of RhoA and Rock is required for skeletal muscle differentiationLoriana Castellani
Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche, 00016 Monterotondo Scalo RM, Italy
J Biol Chem 281:15249-57. 2006..Finally, we have reported that Rock acts independently from RhoA in preventing myoblast exit from the cell cycle and commitment to differentiation and may receive signaling inputs from Raf-1 kinase...
- Myostatin imposes reversible quiescence on embryonic muscle precursorsHelge Amthor
Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK
Dev Dyn 235:672-80. 2006..We report that in contrast to the down-regulation in expression of Pax-3, Myf-5, MyoD, and Myogenin, expression of Pax-7 was maintained...
- MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regionsCristina Giacinti
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 206:807-13. 2006....
- Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonucleiJon Philippe K Hyatt
Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Am J Physiol Cell Physiol 285:C1161-73. 2003..A rapid increase in myogenin and, to a lesser extent, MyoD mRNAs and proteins was observed in denervated and SI muscles: at the later time ..
Research Grants70
- DESMIN AND VIMENTIN DURING MYOGENESISYassemi Capetanaki; Fiscal Year: 1993..in replicating presumptive myoblasts proceeding the expression of the myogenic regulator myoD and possibly myogenin. Terminal differentiation of skeletal muscle is associated with down regulation of vimentin and up regulation of ..
- IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATIONStephen Rosenthal; Fiscal Year: 2002..In this proposal we will examine the mechanisms by which IGF-I initially inhibits and subsequently stimulates myogenin gene transcription, and we will evaluate the potential role of the cdk4/cdk6 inhibitor p19 in mediating the ..
- TURNING SCAR INTO VIABLE MYOCARDIUMRace Kao; Fiscal Year: 2004..Proteins specific to cardiac or skeletal muscel (TnI, myosin, connexin 43, myogenin) will be used to indicate the phenotypes of regenerated muscle by identifying the specific mRNA (Northern blot, ..
- FUNCTIONAL ANALYSIS OF MRF4 ACTIVITY DURING MYOGENESISSTEPHEN KONIECZNY; Fiscal Year: 1993..of the basic/helix-loop-helix (b/HLH) protein family that also includes the muscle regulatory factors MyoD, myogenin and Myf-5...
- MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIASTEPHEN ALWAY; Fiscal Year: 2001..The overall goal of this proposal is to determine the significant of MRF transcription factors MyoD and myogenin in satellite cells and myonuclei of aged muscle...
- The Role of RNA-Binding Proteins in MyogenesisLubov Timchenko; Fiscal Year: 2007..expression of CUGBP1 in skeletal muscle in vivo leads to an abnormal expression of myogenic regulators (p21, myogenin, MEF2) that is accompanied by significant loss of mouse weight and by underdevelopment...
- Innervation-Dependent TranscriptionSTEVEN BURDEN; Fiscal Year: 2004..b>Myogenin is a good candidate for a transcriptional mediator of electrical activity-dependent transcription, as myogenin ..
- MOLECULAR BASIS OF MYOGENIC RESPONSE IN DEVELOPMENTM Siddiqui; Fiscal Year: 2003..regulation was brought by the discovery of the activator myogenic regulatory factors (MRFs), MyoD, myf-5, myogenin, MRF-4, it is now becoming clear that other mechanisms, wherein the myogenic regulation can be attributed to the ..
- PAX-3 AND THE REGULATION OF SOMITIC MYOGENESISANDREW LASSAR; Fiscal Year: 2000..Pax-3 (which is normally expressed in the dermomyotome) is sufficient to induce expression of MyoD, Myf-5 and myogenin in paraxial mesoderm in the absence of inducing tissues...
- REGULATION OF PURKINJE FIBER DEVELOPMENT IN THE HEARTTakashi Mikawa; Fiscal Year: 2005..first time that myocytes undergoing Purkinje fiber differentiation express at least two factors similar to myoD/myogenin members of the bHLH transcription factor gene family...
- INTERFERON ANIMAL VIRUSES AND PROTEIN SYNTHESISPeter Lengyel; Fiscal Year: 2005..The transcription factors affected by p202a include: AP2, E2F-1, E2F-4, MyoD, myogenin, NF-kB, c-Myc and p53. By binding UBF, p204 inhibits ribosomal RNA synthesis...


text:
Privacy Policy
IDFX Pty Ltd is strongly committed to protecting your privacy. Whether you're interacting with our online content, products or services, our goal is to provide you with a safe and secure environment that you can both trust, and rely on.
The purpose of this privacy policy is to inform you of how we gather information, what we do with that information, your choices with regard to that information, and your ability to make changes and corrections. Our policy is there to ensure that you have control of your privacy, the information we collect, and the way that we use it while still maintaining a satisfying experience.
Collection of Information
There are two types of information that we collect; Anonymous, and personal.
Anonymous data collection is used solely for statistical purposes. For instance, we may keep track of how many times our privacy policy is viewed, or if the answer to an FAQ was able to help a user. Anonymous data collection does not collect information like names, email addresses, or any other data that could be used to identify a person or company.
Personal information is collected primarily as a means of verifying who you are. Much of the information that we have on offer is restricted to access by our client members. As such, you will need to complete a member registration form and have your identity verified before access will be granted. During the registration process, the data that you provide is only intended to verify your identification. Please read the "Disclosure" section that is following. Your IP address will also be recorded with your registration and may be used for statistical purposes at a future date.
Client Participation Programme (CPP)
Clients wishing to participate in our referal programme (known from here-on as "CPP") will need to supply us with information, some of which will be publicly accessible. Participation status and the details being made available may be altered through the membership area by a client representative at any time. Once removed from the CPP, all CPP details will be removed permanently from our database. This will not effect the member status although a member can choose to permanently delete their account at anytime as well.
Your email address
The email address you provide during the member registration process is used to send verification of changes to your membership. It will also be used to send you your password should you forget or have it reset. It will not be on-sold, exchanged, made available publicly or otherwise to any third party person, company or vendor. It will not be visible outside of our database, or be accessible to anyone other than a person with your login details (username and password) and the administrative staff at IDFX Pty Ltd.
Your user name
For security purposes, your unique user name that you create during the member registration process will remain hidden. It will only be used to identify you during the login process and with some feedback forms within the member area.
Statistical Data
The IDFX Pty Ltd site keeps track of how many visitors look at our pages, the frequency of visits, where they move within the site, and how long they spend looking at data. This anonymous information allows us to improve the site to ensure a more satisfying experience can be enjoyed by all.
The IDFX Pty Ltd site uses cookies primariily to distinguish members from guests. In order to take advantage of member privileges, cookies must be activated for our site.
We may at times need to disclose your personal information. We may be required by law to disclose information, or in some cases require giving your details to thrid parties to provide the service you have requested. For example, if you purchase a product from us online, we may seek to have that item shipped direct from the vendor. We may provide billing or shipping information in that case. Your details will only be disclosed if it is neccessary to fulfil the purpose for which you provided your personal details. Other than that which is stated above, we will not disclose your personal details such as name, phone number or email, to any person or organisation outside of IDFX Pty Ltd, unless you have expressly authorised us to do so. An example of that would be by being involved in the CPP.
Sale of Personal Information
Under no circumstance will IDFX Pty Ltd sell or receive payment for disclosure of your personal information.
IDFX Pty Ltd is dedicated to keeping our client data secure. As new methods of securing media becomes available, we will endeavour to keep our storage sites updated with suitable security measures. Ultimately, you are responsible for maintaining the secrecy of your password and access to your personal details through your membership account.
Changes and Corrections
In the case where IDFX Pty Ltd holds your personal information, we will endeavour to make that data accessible to you in such a way that you can keep your current information accurate, complete and up to date.
Privacy Complaints
If you have any compaints relating to online privacy issues, please feel free to contact us directly so that we may better assist you personally.
Changes in Our Privacy Policy
We may at times update our privacy policy. Any changes will be displayed in this document.

subset: commoncrawl


text:
Route Guide - iPhone / Android - Partners - Forum - Photos - Deals - What's New - School of Rock
Routes Sorted
L to R R to L Alpha
Climb ledge to ledge, great stances abound. Plenty of backstep opportunities and no hands rests/placements. This route gets greasy, so it can easily psyche you out. The crux is moving under the roof, which looks intimidating from the ground but all the positive holds are solid making this thing a blast for anyone. Only downside, is you can't get a clean fall with so many ledges.
The Left most route on the main wall. The obvious Dihedral
Big gear down low and normal stuff up top. Use a long runner under the roof to reduce rope drag.


text:
BLACK EARTH (WKOW)-- People in the town of Black Earth are mourning the sudden death of a respected friend. Wednesday morning 44-year-old Dave Seymour died after his SUV was rear-ended and pushed in front of an oncoming semi.
Even though Seymour worked in Middleton for the American Girl Company and lived out in the country near Mount Horeb, friends say his heart and soul was fully invested his small community near Black Earth and Mazomanie. A place where people honored him as a role model
Those that knew him say Dave Seymour was many things during his life, a soldier, hard worker, father and friend, but above all else a mentor.
"It was all about the kids with Dave and whatever was in their best interest is how he approached his program," Pete Jopke explains. "He's going to be sorely missed."
For several years Seymour worked as a coach and coordinator in the Wisconsin Heights youth football program teaching hundreds of kids the fundamentals of the game. Close friend and varsity football coach Pete Jopke says Dave saw it as much more than that.
"It was kind of ironic because the last part of our conversation we talked about football being one of those sports that teaches life lessons. I think this is a lesson here, this tragedy, that's going to be pretty tough to get our hands around," Jopke says.
Whenever Seymour left the football field his mentoring skills went with him. They followed him to the very depths of his heart to New Heights Lutheran Church where he served as a board member and mentor to a handful of confirmation students. Seymour was expected to meet with his group the night he died.
"So Wednesday night we just scrapped our plans and had a prayer service with candles. It was a time for people to just cry and hug and be together. People just flocked to this place because they needed that. They were so traumatized," Pastor Rob Nelson says.
The trauma quickly spread throughout a community of only 1,300 people. Many community members knew Seymour as the fun-loving guy who always wore a smile, a man eager to help anyone who asked for it.
"You never walked away from a conversation with Dave without feeling uplifted in some way," Nelson says.
The crash Dave Seymour was involved in is still being investigated by the Dane County Sheriff's office. His funeral will be held Monday morning in Black Earth.
All content © Copyright 2000 - 2014 WorldNow and WKOW. All Rights Reserved.
For more information on this site, please read our Privacy Policy and Terms of Service and Mobile Privacy Policy & Terms of Service.
Persons with disabilities who need assistance with issues relating to the content of this station's public inspection file should contact Anna Engelhart at 608-661-2767. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, at 888-835-5322 (TTY) or at firstname.lastname@example.com.


text:
Hip Hop News: Rapper Who Committed Suicide Is NOT Connected To Tyga
Jason Lee spoke to a source close to Seattle rapper Freddy E who reportedly committed suicide within the last 24 hours. Reports connected the comedian / rapper to YMCMB rapper Tyga, even labeling him as his artist. It was confirmed that not only was Freddy E NOT Tyga's artist, he doesn't even know him. The source said that although Tyga didn't know him personally his heart went out to the deceased rappers family.
Another source close Tyga said that the only indirect connection that could have been made between Freddy E and Tyga is that Freddy was dating Tyga's artist Honey Cocaine. As reported earlier, Honey Cocaine sounded off on her Twitter account defending herself that she had anything to do with the rappers decision to shoot himself.
Although there has been no official word from Tyga, and most likely won't be, Honey Cocaine is giving an official interview with Los Angeles radio Power 106 tomorrow so we're surely hear details of what's unfolding.
That raises a question though. Isn't it too soon for folks to be doing interviews if their boyfriend or better half just blew their brains out over you? Kinda weird.
Anyhow, tell us what you think!


text:
All Pants on Fire! statements involving David Dewhurst
Wendy Davis "was just doing a fund-raiser in Chicago with the international socialists organization."
Dan Patrick "changed his name from Danny Goeb to hide from" his "debts."
The White House had a live video feed of the Benghazi attacks as they occurred.
Ted Cruz "helps run two national organizations that have been leading the push to give amnesty to illegal immigrants."
Page 1 of 1
How to contact us:
We want to hear your suggestions and comments. Email the Texas Truth-O-Meter with feedback and with claims you'd like to see checked. If you send us a comment, we'll assume you don't mind us publishing it unless you tell us otherwise.
Browse The Texas Truth-O-Meter:


text:
World No. 1 Victoria Azarenka was surprised with an early-round defeat by world No. 16 Dominika Cibulkova on Sunday at the French Open. Now, Azarenka announced she will take a break from tennis to be mentally prepared for Wimbledon. It'll be a short break with the tournament beginning in 21 days. Although in tennis time, that's almost as much as their entire offseason.
Azarenka began the year on a 26-match win streak. Writers were calling her the female Djokovic. Since Marion Bartoli snapped that streak in the quarterfinals of the Sony Ericsson Open, Azarenka hasn't won a tournament. She has finished as the runner-up in two tournaments (Stuttgart and Madrid).
From the BBC:
"There has been a lot of tennis for me in the last five months," she said. "I need just to get rested mentally, definitely. Once I have my passion and desire back on the court, I'll be on the grass. ... I don't know how to describe my performance really. It wasn't satisfying at all. But I guess it happens. I don't know even what to find positive in my performance."


text:
Fire crews are investigating an early morning fire in Toledo.
It happened around 6:45 a.m. in the 1700 block of Macomber.
Toledo firefighters were able to quickly contain the flames.
Crews say the house appeared vacant and no one was hurt fighting the blaze.
Investigators are now checking for possible signs of arson, to see if someone set the house on fire on purpose.


text:
I love getting fabric made by two different manufacturers, from two completely different sources, at two different times ... and then later realising they are a wonderful match! Although the colours in the photo above may not accurately tell the tale, that is what happened with these fabrics. I bought the Michael Miller Groovy Guitar online thinking I could work it into a quilt for my nephews because my brother is a great guitar player. I bought the dots which are Funky Flowers by Linda Lum DeBono for Henry Glass a month or two later at a store, just because they were great looking dots. Then, fast forward to a scene of me rearranging things in my fabric storage drawers and ... ta,da! I am still not sure exactly what quilt these will end up in, but I think they should probably be permanently stitched together.
Friday, June 4, 2010
Fun or Fabulous Fabric Friday #1
Posted by Riel Nason at 12:01 AM
1 comment:
- wishes, true and kind said...
Oh, I love it when that happens too.
- June 4, 2010 at 1:23 AM
Subscribe to: Post Comments (Atom)


text:
Long-time Indiana Pacers forward Danny Granger has been traded to Philadelphia.
Yahoo! Sports reported Thursday the Pacers agreed to send Granger to the 76ers just before the NBA's trade deadline. Indiana will get Evan Turner, the second player taken in the 2010 NBA Draft, and Lavoy Allen from Philadelphia.
The Pacers confirmed the trade Thursday night.
During some lean times, Granger was the Pacers' go-to guy, but over the years, nagging injuries, reduced playing time and a big contract made him expendable. He is averaging just over eight points a game this season, after missing several games at the start of the year due to injury.
"We thank Danny for his eight-and-a-half seasons with us and we appreciate everything he did for us in his time here," said Pacers President of Basketball Operations Larry Bird. "We felt we needed to make this trade to strengthen the core unit and our bench. In Evan and Lavoy, we think we got two really good players that can help us and we look forward to what they can bring."
Turner is averaging over 17 points per game for a struggling 76ers team and can also help the Pacers with his defense.
Both Granger and Turner are in the final year of their respective contracts and did not figure to return next season. Granger has spent his entire career in Indiana after being drafted in the first round of the 2005 NBA Draft.
Philadelphia will also reportedly receive a future second-round pick from the Pacers in the deal.
Indiana waived guard Orlando Johnson to make room on the roster for the new acquisitions.
Links to the FCC website to view WTHR and/or WALV's on-line public inspection files:
WTHR: https://stations.fcc.gov/station-profile/WTHR || WALV: https://stations.fcc.gov/station-profile/WALV
Individuals with disabilities may contact Jill Pursell at email@example.com, or 317.655.5602, for assistance with access to the public inspection files.
All content © Copyright 2000 - 2014 WorldNow and WTHR. All Rights Reserved. For more information on this site, please read our Privacy Policy and Terms of Service.


text:
This weekend on Carolina Journal Radio
State lawmakers will return to Raleigh in May for their official short session, but many of them are already busy working in study committees. Becki Gray offers a 2014 legislative preview during the next edition of Carolina Journal Radio.
Speaker of legislators, you'll hear Rep. Mike Hager, R-Rutherford, discuss his ideas for addressing energy, the economy, and the environment, and you'll hear highlights from a recent legislative debate over targeted tax incentives.
Assistant N.C. Commerce Secretary Dale Folwell explains why the state is instituting a photo identification requirement for unemployment benefits, and Ardis Watkins of the State Employees Association of North Carolina shares that group's concerns about management of the state's pension fund for retired government workers.


text:
WASHINGTON (AP) - A look at some of President Barack Obama's promises for his second term:
-Roll back Bush tax cuts for upper-income people, couples making over $250,000 and individuals making over $200,000, a failed 2008 promise. Ensure people making over $1 million pay at least 30 percent in taxes.
-Put government on a path to cutting deficits by $4 trillion over 10 years. First-term promise to cut deficits by half failed.
-Cut imports of foreign oil by half by 2020.
-End subsidies to the oil industry. "I will not let oil companies write this country's energy plan or endanger our coastlines or collect another $4 billion in corporate welfare from our taxpayers." A leftover promise.
-"As long as I'm president of the United States, Iran will not get a nuclear weapon." Using sanctions and negotiation, with force if needed. "We're going to make sure that if they do not meet the demands of the international community, then we are going to take all options necessary to make sure they don't have a nuclear weapon."
-End tax breaks for companies shipping jobs overseas.
-As his second priority after a deficit-cutting deal, achieve an immigration overhaul that sets a path to citizenship for illegal immigrants under certain conditions. An unfulfilled 2008 promise. Implemented a temporary measure in June letting up to 1.7 million young illegal immigrants stay and work for up to two years.
-Make higher education affordable for everyone, in part by halving the growth in college tuition over 10 years. Ensure by the end of the decade that the U.S. has more people with college degrees than any other country, recruit 100,000 math and science teachers in 10 years, help 2 million workers attend community college.
-"Continue to reduce the carbon pollution that is heating our planet." Latest iteration of a broken 2008 promise to enact a climate-change law.
-"When Obamacare is fully implemented, we're going to be in a position to show that costs are going down." Latest and much less ambitious iteration of failed 2008 pledge to cut average family premiums by $2,500 in first four years.
-Strengthen Medicare by reducing the cost of health care. Steps already taken under the health care law improve benefits while cutting payments to hospitals and other providers by more than $700 billion over a decade - cuts used to help working-age Americans get insurance. "I will never turn Medicare into a voucher."
-Double exports and create 1 million new manufacturing jobs in four years. Manufacturing jobs have been steadily declining for nearly two decades.
-Consolidate various federal agencies dealing with business issues into one new department led by a secretary of business.
-For victims of Superstorm Sandy: "We are going to be with them every step of the way in helping them to rebuild their lives."
-"Let's, especially, hire our veterans, because if you fought for this country and its freedom, you shouldn't have to fight for a job when you come home."
All content © Copyright 2000 - 2014 WorldNow and WXOW. All Rights Reserved.
For more information on this site, please read our Privacy Policy, Terms of Service and Mobile Privacy Policy & Terms of Service.
Persons with disabilities who need assistance with issues relating to the content of this station's public inspection file should contact Administrative Assistant Theresa Wopat at 507-895-9969. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, at 888-835-5322 (TTY) or at email@example.com.


text:
La Jollans Irwin and Joan Jacobs to receive Neil Morgan Award
Irwin and Joan Jacobs of La Jolla are among the individuals to be honored Thursday, May 23 at the 11th annual Visionary Awards presented at the Hilton San Diego Bayfront. The Jacobs will receive the 2013 Neil Morgan Award for Lifetime Achievement, named for another La Jolla resident, former newspaper editor Neil Morgan.
Also being honored are Dr. Elizabeth "Betty" Jones, founder of the Foundation for the Children of the California; Malin Burnham, Bill Geppert, Bob Kelly and Peter MacCracken of Our of Greater San Diego Vision, a framework designed to capture the community's vision for the future of our region; Bruce Boland, Thella Bowens and Robert Gleason of the San Diego County Regional Airport Authority; and Tijuana Mayor Carlos Bustamante and former San Diego Mayor Jerry Sanders.
The recipient of the Community Spotlight Award will be announced at the event. For ticket information, visit leadsandiego.com or call (619) 280-5323.
Related posts:
- Salk Institute names duo to Dulbecco, Guillemin chairs
- Riford Library seeks art for upcoming exhibition
- Kayak fisherman with prize catch off La Jolla speaks out against marine protected areas taking effect Jan. 1
- Gotta Work
- Bird Rock celebrates community at summer picnic
Short URL: http://www.lajollalight.com/?p=100700


text:
Join Now
Join ePHOTOzine, the friendliest photography community.
Upload photos, chat with photographers, win prizes and much more for free!
New PortraitPro 12 SALE + 10% OFF code EPZROS814
Nic_WA | Send a Private Message | Visit My Website | Facebook
Thanks for dropping by
Nic_WA's Portfolio
Current Filter:
No tag filter applied


text:
Theme: Cultivating Innovation
Monterey, CA, United States
April 15th, 2011
About this event
Our proposed theme is "Cultivating Innovation". For us, this means, unpacking "innovation" as a creative process. The questions that are guiding us as we explore the theme of cultivating innovation have been taking a deeper look into the practical side; how to recognize good ideas, how to nurture creativity, how to unleash good ideas, when to jump and when to stop and what the potential side-effects of innovation can be.
Our speakers will come from the local community as well as the Bay Area and the idea is to present the life cycle of new ideas from inspiration to implementation stopping along the way to talk about failures as well as successes. We will look at the sciences, education, development, arts and technology.
Confirmed Speakers
Jennifer Perlmutter
"Each painting begins with journaling, contemplating the life force that gets me – all of us – moving to overcome everything from ennui to atrocities. I seek the spirit that gets people to show up every day, ready to proceed and progress, regardless of what came before. And I noticed that the causes of darkness dissipate. Indeed, All Things Go. Everyone, everyday, can be a phoenix rising from the ashes." After childhood in Napa, California, and many years in the high-energy cities of Boston, New York and Los Angeles, artist Jennifer Perlmutter subtly balances the influences of nature and civilization in her work. She combines environmental character with urban features in a complex layering to create a push-pull of color, figure and texture. With a lifelong interest in the creative merging of art and crafts, her career began with gilding, paint and other media. She produced chinoiserie, artwork and deep, layered finishes on high-end furniture. Much of this work has been featured in LA's Pacific Design Center and in the homes of celebrities such as Ted Danson & Mary Steenburgen, Eddie Murphy and Burt Bacharach. By 2001, Perlmutter devoted herself to fine art, exploring metal leaf, watercolor, acrylics and oils. She ultimately found her niche in mixed media on wood and canvas, which she continues to use as her predominant medium today. The artist's work has been collected internationally and shown in New York, Beverly Hills, Santa Barbara, Los Angeles and Kansas. Her vision and strong command of application techniques led to commissions from several premier destinations including The Mirage and Hilton hotels in Las Vegas, Seoul's Traum Haus and Toronto's Casino Niagara. Her art has also appeared in numerous feature films and television shows, such as Brothers and Sisters, War at Home, The Closer, Huff, Heroes, All of Us and more. Jennifer Perlmutter lives and works in the east bay of the San Francisco bay area.
F. Noel Perry
As an investor, Noel has focused on socially responsible, innovative and profitable ventures. He is the founder of Next 10, an independent, nonpartisan organization that educates, engages and empowers Californians to improve the state's future. Next 10 is focused on innovation and the intersection between the economy, the environment, and quality of life issues for all Californians. They create tools and provide information that fosters a deeper understanding of the critical issues affecting all Californians. Through education and civic engagement, their hope is that Californians will become empowered to affect change. Additionally, Mr. Perry has backed multiple business successes like the interactive educational company Leap Frog and the organic baby food company Earth's Best. The father of five, Noel Perry has lived in California for more than 20 years. Since founding Next 10, Noel has redirected his time and resources from his venture capital firm to this organization because of his commitment to the future of California and confidence in the state's ability to lead the world through innovation.
Margarita Quihuis
A social entrepreneur and mentor capitalist, Margarita Quihuis's career has focused on innovation, technology incubation, access to capital and entrepreneurship. She is a member of the Stanford Persuasive Technology Lab which creates insight into how technology can be designed to inspire people and create a better society. Her accomplishments include directorship of Astia (formerly known as the Women's Technology Cluster) where her portfolio companies raised $67 million in venture funding, seed stage venture capitalist, Reuters Fellow at Stanford and Chairman and President of Hispanic-Net. Her current efforts include access to development capital through the productive use of remittances for the unbanked both in the United States and in developing countries through her program, Indigo Financiera and developing and advising companies that tap into the market needs of transnational workers and their families. In 2004, she was recognized by Women's eNews as one of their '21 Leaders for the 21st Century' for her efforts in increasing access to capital for women entrepreneurs and was named as one of WITI's Women to Watch in 2003. In 2007 she was named 'One of The 100 Most Influential Latinos in Silicon Valley.' Ms Quihuis has served as a consultant to the US State Department on entrepreneurship. She has been widely quoted in the Asian Venture Capital Report, NewsHour with Jim Lehrer, US News & World Report, Forbes ASAP, Red Herring, CNN and CBS MarketWatch. Ms. Quihuis is the founder of 1st Wednesdays, the network for women in venture capital. From 1995 to 2000, she served as a board member of the Forum for Women Entrepreneurs, and was a member of the screening and coaching committees for Springboard 2000, the venture capital conference for women. Ms. Quihuis is a past board member of NanoSig, a Northern California based organization dedicated to the commercialization of nanotechnology. She currently sits on the boards of Agent Software, Women's eNews, Instituto Pro Musica de California and the James Burke Institute and is a member of the advisory boards for Mira This, Tierra Natal and Merrill Lynch's Latino Advisory Council. She was also part of the founding working group for the Business Women's Initiative on AIDS.
Lee Lorenzen
Lee Lorenzen is a successful serial/parallel entrepreneur with more than 26 years of experience developing software and founding and/or funding numerous ventures and non-profit organizations. He is currently President, CEO of Altura Ventures. Prior to Altura Ventures, he founded SHOP.COM (1997-2007) and as CEO/Chairman led the company from simply an idea to its current place as one of the Top 10 most trafficked multi-vendor shopping sites on the web. Lorenzen's first start-up was Ventura Software (1985-1990) where he co-wrote Ventura Publisher — the fastest desktop publishing system available on the PC. It was licensed to Xerox and achieved annual sales in excess of $50 million. Next, Lorenzen founded Altura Software (1990-Present) and created the Mac2Win software which was used to port 60+ Mac applications to Windows (including ClarisWorks, Macromedia Director and Fractal Design Painter). Over the years, Altura generated $15+ million in revenue, reached the Softletter's Top 100 list and achieved Sales Per Employee levels in the Top 10 of all software companies. Lorenzen also founded and assembled the management team of Fractal Design Corporation (1992-1996), which went public in 1995 before ultimately being acquired by Corel. Next, he co-founded PGSoft (1998-2001) which was sold to Novell after creating the Cody-award winning IFolder product. Earlier in his career, Lorenzen developed some of the world's first graphical user interfaces. After graduating valedictorian from SMU with a BS in Computer Science, he joined Xerox, where he developed an icon-based graphical desktop user interface called Lone Star in 1981 (just prior to the shipment of the IBM PC). Next, he joined Digital Research Inc. (DRI), where he developed a graphical windowing system and user interface for the PC called GEM that was an early competitor to Windows and Macintosh. Lorenzen holds a patent as co-inventor of the Universal Shopping Cart.
Andrea Olsen
Andrea Olsen is the John C. Elder Professor of Environmental Studies and Professor of Dance at Middlebury College in Vermont. Author of Body and Earth, An Experiential Guide, and Bodystories: A Guide to Experiential Anatomy with Caryn McHose, she teaches internationally including annual Body and Earth training programs in Europe and the U.S. Andrea is on faculty of the teacher-training program at Yoga Center Amherst in Massachusetts, and recipient of several awards including a Fulbright Senior Scholar residency in New Zealand, Mellon funded initiatives in Ecuador, Germany, and Denmark, and a Contemplative Practice Fellowship through ACLS to introduce contemplative traditions into the college curriculum. She continues to perform globally, exploring the range and relevance of dance in contemporary societies.
Seth Linden
Seth Linden graduated from Stanford University with a B.A. in Human Biology and from Brown University with a Masters in Teaching. He has 18 years of teaching and tutoring experience, starting when he was in high school tutoring his friends for free. He has taught in both public and private schools, from Atherton and Oakland, CA, to Providence, RI. Seth has taught SAT classes, helped students pass the HSPT and CAHSEE, and has tutored all areas and levels of math and science. Seth started Tutorpedia, a one-on-one tutoring company based in San Francisco, in 2005. Over the years, his company has expanded to include tutors for all subjects and all needs, addressing students at all levels – elementary school, middle school, high school, and college. In 2009, Seth established a nonprofit tutoring organization, Tutorpedia Foundation, whose mission is to provide high-quality, personalized tutoring to underserved students. Seth believes that learning needs to be more real, relevant, and rigorous, with a singular focus on personal relationships. He will be married in July and looks forward to his life of teaching and traveling with Sara!
Sujata Millick
Sujata Millick is a Visiting Researcher at Hewlett-Packard Labs in Palo Alto, CA, where she is examining public-private approaches to cyber security and sustainable IT. She is on assignment from the Department of Navy's Office of Naval Research, where she recently served as the Deputy Director of Research.
E.J Svensson
E.J. Svensson's career has taken him from his industrial engineering origins, with focus on continuous improvement, to mold-breaking innovations in media and now to his latest project; a comprehensive book chronicling the events and aftermath of the banking crisis in Northern Europe from a political and historical perspective.
Venue and Details
Irvine Auditorium
499 Pierce Street
Monterey, CA, 93940
United States
More about the venue »
This event occurred in the past.
See more TEDxMonterey events »
Maureen Fura
Monterey, CA, United States


text:
Financial Daily from THE HINDU group of publications
Thursday, Mar 24, 2005
Sona Koyo chief confident of Rs 350-cr turnover
R.Y. Narayanan
Coimbatore , March 23
SONA Koyo Steering Systems Ltd (SKSSL) is on course to achieve sales turnover of Rs 350 crore during the current fiscal, but a more challenging target of Rs 425-450 crore has been set for the next fiscal, according to the company's Chairman and Managing Director, Dr Surinder Kapur.
He expects the acquisition of a 21 per cent equity stake in a French company will help increase export income.
Speaking to Business Line, Dr Surinder Kapur said he was confident that SKSSL, which primarily manufactures steering systems and driveline products for cars and utility vehicles, would achieve a gross sales turnover of around Rs 350 crore compared to Rs 287 crore sales in the previous year. The export turnover would be Rs 25 crore during this year compared to Rs 5 crore in the previous year. The original export target was Rs 30 crore but because of the surge in domestic demand faced by many of its suppliers, it could not be met.
He said the company was looking at `more challenging targets' during next year with sales moving closer to Rs 425-450 crore, and with exports touching at least Rs 50-60 crore. A team from France would visit India next month to decide on purchases from India.
He said while the benefit of the stake pick up by Sona Koyo in Fuji Autotech of France would be felt next year itself, the full impact would be visible in 2006-07. SKSSL wanted to increase its export sales to Rs 100 crore by 2007 and this would be part of that goal. Dr Surinder Kapur said the company's board had earlier approved a capital expenditure of about Rs 120 crore over a two-and-a-half year period. During this year, about Rs 50 crore was spent and during next year, the balance Rs 70 crore would be invested in plant and machinery. Asked whether the PAT of Rs 12.1 crore when compared to the turnover of Rs 287 crore recorded last year was not low, the Sona Koyo CMD said that in the last two to three years, there was continuous increase in steel price, all of which the company was not able to pass on to customers. The margins have come under pressure and prices have not been increased. The company was able to cut costs but at times it could not keep pace with the increase in price of raw materials.
Article E-Mail :: Comment :: Syndication :: Printer Friendly Page
Stories in this Section
The Hindu Group: Home | About Us | Copyright | Archives | Contacts | Subscription
Group Sites: The Hindu | Business Line | The Sportstar | Frontline | The Hindu eBooks | The Hindu Images | Home |
Copyright © 2005, The
Hindu Business Line. Republication or redissemination of the contents of
this screen are expressly prohibited without the written consent of
The Hindu Business Line


text:
SKYFOX 5 flew over the storm damage in Floyd County and in Summerville. The towns of Concord, Zebulon and Cave Springs also suffered damage during Monday's severe storms.
Click on the video to view aerial footage of the damage shot by SKYFOX 5!
KDFW FOX 4400 N. Griffin StreetDallas, Texas 75202
Main Station Directory:(214) 720-4444News Fax:(214) 720-3263 or (214) 720-3333


text:
John Langston Kuempel (born May 11, 1970), the salesman in Seguin, Texas, who is a Republican member of the Texas House of Representatives from District 44
Harry McLeary Wurzbach (May 19, 1874 – November 6, 1931), the first Republican since Reconstruction to represent Texas for more than two terms in the U.S. House of Representatives
Edmund Perry Kuempel (November 29, 1942–November 4, 2010), the Republican member of the Texas House of Representatives from District 44, based at Seguin, the seat of Guadalupe County in central Texas
Evi is our best selling mobile app that can answer questions about local knowledge, weather, books, music, films, people and places, recipe ideas, shopping and much more. Over the next few months we will be adding all of Evi's power to this site.
Until then, to experience all of the power of Evi you can download Evi for free on iOS, Android and Kindle Fire.


text:
Federal Premium Independence Ammo, 5.56x45mm, 55-gr., FMJ
An affordable round for target shooting practice
Brand new, non-corrosive ammo
Top-notch components for consistant accuracy
Boxer-primed, reloadable brass cases
FNH USA Sporting Handgun 5.7x28mm, 40-gr., V-Max, 50Rd Ammo
Target shooting, general plinking and small game
Features a 40-gr V-Max
Offers explosive performance on game
Accurate, flat-shooting round
Winchester Varmint X Ammo
Designed for varmint and predator hunting
Polymer-tipped bullet for long-range accuracy
Explosive fragmentation on impact
Devastating terminal performance
Stack-On Shooter's Pistol/Ammo Safe, Black with Chrome Accents
Approved by CA Department of Justice
Withstands 1400 for 30 minutes
A total of 8 separate locking points
Adjustable shelves carpeted interior
Offers 5.7 cubic feet of storage space
Remington Express Air Rifle
Hardwood stock with grip checkering
Break barrel action and rubber recoil pad
Two-stage trigger design
Full-sized stock
Fiber optic iron sights a 4x32mm scope
New! CVA Optima V2 Muzzleloader Package, .50, Full Realtree APG ...
416 stainless steel, fluted 26" barrel
Quick-Release Breech Plug
Solid-aluminum PalmSaver ramrod
Package includes scope and soft case
GunVault Mini Safe
Made of heavy-duty 16-gauge steel
Unique No-Eyes Keypad is easy to use
Built-in computer protects from unwanted entry
12 million user-selected access codes
Federal Top Gun Target Loads 250Rd-Case
High-strength hull for reliable performance
Specially designed Triple Plus wad column
Clean-burning powder for reliable ignition
250 shells per case
Liberty Centurion Voyager Series Gun Safes
Amazing protection at a value price
3-in-1 Flex interior for organization
80,000 BTU rating for 45 minutes at 1200
Thick 12-gauge body with strong welding
Exclusive Gold Service In-Home Delivery
New! Barska Quick Access Biometric Rifle Safe
Biometric lock opens with a fingerprint scan
Internal 4-position barrel rest for organization
Removable storage shelf for ammo and gear
Includes all necessary mounting hardware
New! Gunvault Wall Vault, Electronic Lock
Mounts between the studs in your walls
Easily conceals your valuables
Durable all-steel construction
Drop-down door opens instantly
False bottom secret compartment
Leupold VX-2 Riflescope
Optimal brightness, clarity, and contrast
Consistantly accurate, ethical long-range shots
DiamondCoat lens coating on exterior lens surfaces
Waterproofing with Argon/Krypton gas blend
Thompson/Center Pro Hunter FX Muzzleloader
Fixed-barrel muzzleloader
Tough Weather Shield break-open action
Fluted 26" barrel
QLA muzzle system for easy loading
Speed Breech 3 breech plug
Winchester Xpert Steel Game & Target Loads, 100 rounds
Corrosion-resistant steel shot
High-velocity for fast-moving targets
Produces consistent patterns
More pellets per ounce than lead
4 boxes of 25 rounds
Remington Gun Club Target Loads 250Rd-Case
An excellent choice for economical shooting
Premier STS primer and Power Piston wads
Reliable, consistant, and reloadable shells
Case of 250 shells
New! Trijicon ACOG 4x32 Scope with Red-Dot Sight, Dual ...
Fiber optics and tritium for easy acquisition
Built-in red-dot sight for close-range use
Ranging reticle allows for bullet-drop
Remington HTP Jacket Hollow Point Handgun Ammo
Designed for amazing terminal performance
Reliable expansion, penetration weight retention
Instant stopping power when you need it most
Precision manufactured in the USA
50 rounds per box
Boyt Premium Single Handgun Case
High-impact injection-molded resin case
Steel powder-coated draw latches
Waterproof/dust proof O-ring seal
Customizable high-density foam interior
Stack-On Steel Security Cabinets
Secures your rifles when not in use
Easy installation
Durable baked epoxy finish
Key-coded double-bitted locks
Three-point locking system
CCI Blazer Brass Ammo Can
Built to stringent SAAMI standards
Quality and reliability are ISO-certified
Boxer-type primers and primer pockets
Reloadable brass cases for added value
CCI primers for reliable ignition


text:
For the Dough:
1 1/2 cups warm water
1 1/2 Tbsp sugar
1 1/2 Tbsp yeast
1 1/2 tsp salt
3 1/2 cups flour
1/2 pound ground sirloin
1 1/2 cups shredded mozzarella cheese
1/4 cup shredded parmesan cheese
1/4 tsp salt
1/4 tsp dried oregano
Marinara sauce for dipping
1. To prepare the dough, place the warm water in a large bowl. Sprinkle the sugar and the yeast into the water and allow to dissolve. Let the mixture sit for about five minutes. Then, add the salt and three cups of flour. Stir to combine the mixture, then turn the dough out onto a floured surface and work the dough. Knead for about five minutes. Add more flour if the dough is sticking to your hands. Form the dough into a ball, and place it in a greased bowl. Cover with a towel, and let the dough rise for about 45 minutes or until doubled in size. Then punch the dough down. Let it rest while you brown the meat.
2. Preheat the oven to 400°F. Then, place the ground sirloin in a large frying pan, and place over medium high heat. Use a fork to break up the meat, and cook the meat until browned and no pink remains. Drain any grease, and set aside.
3. Turn the dough out onto a large work surface sprinkled with flour. Use a rolling pin to roll the dough out into a large rectangle about 1/4 of an inch thick.
4. Use a spoon to sprinkle the ground meat out onto the dough, and spread around evenly. Then, evenly sprinkle on the shredded mozzarella, shredded parmesan, dried oregano , and salt. Then, starting at one of the long ends, begin rolling the dough, enclosing all of the meat and cheeses inside, and continue rolling until you reach the other long end. You should now have a long tube of dough with all of the toppings neatly enclosed. Then, use a very sharp knife to cut the roll into 1 inch wide discs, and place each disk on a large greased cookie sheet. Continue until you have sliced the entire roll.
5. Bake the pizza rolls for 20-25 minutes, or until they are lightly browned on the top. Allow them to cook on the baking sheet for five minutes, then remove them from the baking sheet and serve with marinara sauce for dipping.
Makes 12 Rolls
Per Roll Calories 195, Fat 5gm, Pro 9gm, Carbs 28gm


text:
Hillsdale County Sheriff's deputies responded to a call of a plane crash on Wednesday at 6:30 p.m. in Adams Township, Michigan.
It happened just northwest of the intersection of Bacon and Bird Lake.
Authorities say they found a single engine plane that crashed into a wooded area.
The pilot, Clarence James Avery, 75, of Clark Lake Michigan, was killed. He was the only person on the plane.
The investigation has been turned over to the FAA in Detroit.


text:
The U.S. Marine Corps used a team of 60 canines on Guam- primarily Doberman Pinschers, German Shepards, and a few mongrels. These "devil dogs" were used on Guam as sentries, messengers, and mine detectors. They proved exceptionally useful in searching out the enemy in caves. They stood up well under fire, saved many lives, and were a boon to troop morale.
U.S. troops were not the only casualties of the battle for Guam. More than 20 U.S. combat dogs were killed in action and laid to rest with great affection and respect. The War Dog Cemetery, originally sited along the Asan River, was moved to U.S. Naval Station, Guam in June 1994.


text:
Win Loader v2.2.1-Daz
Category:Software / Author:Eng.Narouto / Added:30-01-2013, 16:31 / Views:1093 / Eng.Narouto Blog
Direct Win Loader v2.2.1-Daz
Windows Loader v2.2.1-Daz | 5 Mb
This is the loader application that's used by millions of people worldwide, well known for passing Microsoft's WAT (Windows Activation Technologies) and is arguably the safest Windows activation exploit ever created. The application itself injects a SLIC (System Licensed Internal Code) into your system before Windows boots; this is what fools Windows into thinking it's genuine.
It works on 32-bit and 64-bit systems
It's compatible with Windows 7 SP1 and all system updates
It's compatible with all system languages
It can be used to pre-activate Windows
It allows you to install custom OEM information
It features application integrity checking
It supports hidden partitions and some complex setups
It can work alongside Linux's GRUB or any other boot manager
It works with VMware, VirtualBox and Hyper-V
It works with most hard drive encryption software e.g. TrueCrypt or BitLocker
It allows you to add your own certificates and serials externally
It will install just the certificate and serial for users with an existing SLIC 2.1
It features automated system profiling (The application matches everything up for you
Get Win Loader v2.2.1-Daz From Fast Server
- Front End Loader-Laughing With Knives-2CD-FLAC-2008-OZF
- Collection Of Win Loader + CD Keys For Win 7 (Sep 2012)
- Win 7 Loader Activator v2.3.1 Reloaded
- Loader Droid PRO download manager v0 9 6-AnDrOiD


text:
Shop Layla Grayce
View all items from Worlds Away
Classic luxury meets midcentury modern glam on the Worlds Away Surf coffee table. Atop silver hairpin-style legs, an oval black marble top provides a distinct pairing to the transitional sofa.
Worlds Away furniture and lighting is the epitome of transitional style with contemporary lines and traditional materials, unexpected colors and finishes, and a sophisticated aesthetic. From mirrors to table options, mod graphic design details and worldly elements combine in eye-catching pieces. The lighting collection defines retro chic as Worlds Away takes design inspiration from mid-century modern and Hollywood Regency glam periods.


text:
Here's the situation: You've been dubbed the social media expert because it's time to get your community organization into social networking. But Facebook is blocked at work, and you're wondering how you can post about the next Zumba class when you keep getting the Access Denied screen.
This type of situation was a hot topic at last week's social media workshop for local governments and P & R organizations. At the workshop, we discussed how to get around this issue in a non-sneaky way. Here is what people have been doing to use social media in a blocked office: Continue reading


text:
Tom Daley Takes Bronze
Plymouth diver Tom Daley has taken the bronze medal in the 10m platform final.
Huge party is planned for Tom Daleyby Ellie Barker
The 18 year old from Plymouth delighted his fans when he surged to third place in the final of the men's 10m platform. More than 1,000 people crammed on to the plaza in Plymouth. The City Council Leader Tudor Evans says there will be a 'huge party' welcoming all the city's athletes.
Tom Daley wins Olympic bronzeby Ellie Barker
Tom Daley has dedicated his Olympic bronze to his father. The 18 year old from Plymouth won the medal in last night's 10m platform diving.Read the full story
Tom Daley takes Bronze
Tom Daley has won a Bronze medal in tonight's(Sat) 10m platform final. To celebrate, the 18 year old from Plymouth jumped back into the pool at the Olympic Park.
Tom Daley qualifies for 10m platform finalby Ellie Barker
Tom Daley from Plymouth has qualified fourth for the 10m platform final. The event will take place this evening.
Plymouth shows its devotion to diver Tom Daley
Best wishes for Tom Daley from Plymouth College
Best wishes for Tom Daley ahead of diving contest
Tom Daley's teachers and fellow students wish him luck ahead of the Mens 10m Platform at the Aquatics centre this evening.Read the full story
Daley tweets ahead of diving contest
Plymouth diver Tom Daley is competing in the 10m individual platform contest later this evening. The diving will kick off at the Aquatics Centre at 7pm.
Competing in the individual prelims tonight at 7pm :) aaaaaaahhhh!!!!