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Getting here can be half the fun, but not if you don't plan well. Big Bend is one of the most remote areas of the lower 48 states. Because of this, it can be hard to visit, unless you have a good idea of how to get here and how to get around once you are here. Big Bend is a long way from major population centers, and public transportation connections are limited at best. Many people drive all the way, round trip. However, there are other alternatives that may save time, money and stress.
Most who visit Big Bend drive a personal vehicle. Public transportation is available, but not always most convenienent. From most cities of origin, there is a fastest way to get to the National Park Area, as well as alternate routes that sometimes offer more scenery and less stress than the relentless pace of US 90 and Interstates 10 and 20.
Flying commercially will only get you part of the way to Big Bend. However, flying in and renting a car is a convenient and enjoyable way to see Big Bend and the West Texas Mountains.
West Texas grew up around the train, and the train still delivers visitors to Big Bend. Your vacation begins as soon as you take a seat in the city of origin. Please double check with AMTRAK as times may change and schedules sometimes run behind.
The Big Bend is one of the best places in Texas, maybe the world, to ride a motorcycle. There are hundreds of miles of scenic paved highways with mountains and curves galore
Fastest way to drive to Big Bend from Houston is take I-10 about 200 mi. to San Antonio, and either continue I-10 about 315 mi. to Fort Stockton, or you can take US 90 from San Antonio about 160 mi. to Del Rio, then 175 mi. to Marathon.


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While photographing or taking video footage of a federal building may make those around you nervous, it won't land you in jail, according to a court settlement reached in October.
The issue went to court after Antonio Musumeci of New Jersey was arrested by a Federal Protective Service officer last year for videotaping in a public plaza outside the Daniel Patrick Moynihan Federal Courthouse in New York. Musumeci sued the Department of Homeland Security, which oversees Protective Service agents who guard federal buildings.
New federal regulations address the issue of photographing federal buildings. Read the guidelines here.

subset: commoncrawl


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Cloed Due To Fire Scheduled To ReOpen
Old U.S. 30, Plymouth, Indiana
WEBSITE: www.michianaliving.com/hayloft.html
The Hayloft Story
An idea, a location and hard work has brought Plymouth, Indiana the Hayloft Restaurant. This restaurant, is an actual barn built about 90 years ago. This structure, as you see it, has been restored as close as possible to its original state. The stone walls, beams, barn siding and roof are all restored. Ron and Sue Crawford, the owners, welcome you to relax and enjoy a fine dining experience in the old-fashion way.
Your comments are appreciated.
Thank you for joining us this evening.
Home -
Menu -
Banquets -


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Children at Carillon's Children's Clinic got a special surprise Saturday morning.
Several mascots with fur circus were there to bring smiles and laughs to the children and nurses. The characters were in town to perform at the Salem Red Sox game, but wanted to make a special appearance.
"This is the best part of our business. this is when we spread love and touch children that are down and out and our hearts are pure," says Rizo the ringmaster.
The group says this was their visit trip to Roanoke, and hope to come back soon.
WSLS 10, P.O. Box 10Roanoke, VA 24022-0010
Telephone: 540.981.9110
Fax: 540.343.3157
Email: firstname.lastname@example.com


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A driver was killed in an accident in Sandy Springs on Tuesday night, police said.According to authorities, a driver was headed south on Roswell Road when he apparently lost control just south of Pitts Road, left the roadway and struck a tree. The driver was ejected. He was taken to the hospital, where was pronounced dead.The victim's name has not been released. Police say he was the only occupant of the car.
Another Georgia parent has sued his children's school district over guns. The lawsuit is directed at Fulton County schools.
WHBQ-TV | Fox 13 485 S. Highland St.Memphis, TN 38111Main Station: (901) 320-1313Newsroom: (901) 320-1340


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Flash mob – that was our surprise for the 40th anniversary! The whole camp did a flash mob to Lean on Me, which is a classic Pony Farm song. It was really neat! ( I told you I would tell you what the surprise was.)
The 40th Anniversary was beautiful! All the campers and the staff worked really hard on their specialty and to make the farm sparkly. Boy did it sparkle! I am sure Boo will write more about the 40th! She can do it better justice than I can.
On Sunday we spent the day by the pool! There were arts and crafts, tie dying, small animals, summer reading, and practicing for the talent show! It was a great, restful afternoon, after such a busy Saturday.
On Monday we went swimming with the horses! It is a real treat and not something you can do just anywhere! Although all horses can swim; some are better swimmers and enjoy the water more than others! Half the camp went in the morning and the other half went in the afternoon. If campers weren't swimming with the horses, then they were doing horse show entries, talking about the horse show and what to expect, and gathering the proper clothing.
This afternoon the activities are catch riding, vaulting, the pool, playing with the minis, a field trip to Budweiser to see their amazing barns and Clydesdale, and then one of our riding groups is going to an away horse show tomorrow, so they will be getting ready. This will be the first time in several years we have done an away show at camp. We want to start with a small group of campers and horses, and be successful there and then expand and offer it to more campers. The show is 2 towns away in New Ipswich NH. The name of the farm is Furnace Brook. This barn comes to our show, and being in a small horse community, we want to support them and be in their show.
As you can see we are staying busy!


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I will be profiling a quality craft brew each week prior to the game, one that fits with the theme for the week, because beer and game day are highly complementary. Please don't 'rec' this post, as I would like them to roll off the front page each week.
My criteria for this list are:
A) use a combination of foreign and domestic beers that are generally available this time of year
2) only high quality beer
D) beers from a variety of U.S. regions for domestics
Ψ) present a variety of styles, with attention to the season, and do both classic styles and offbeat beers
Mercury) in general, bigger beers for bigger games
All right. We're off...
October 28 - Duke 3:30 p.m. -
The Brewery: Brouwerij Van Steenberge N.V. (for Monk's Café)
Selected Beer: Flemish Sour Ale
And now for something a little bit different, like a Duke football team that is 6-2. The Blue Devils join us the week before Halloween. Let's welcome them to Tallahassee with a devilishly sour brew and scare them off with a frighteningly lopsided score in the end.
Brouwerij Van Steenberge N.V. is a Belgian brewery, and though we've featured another Belgian style in this series (Saison), I think it's time to do a beer from the country itself. This one is distributed pretty widely in the U.S. If you can't find The Monk's Café due to distribution limitations, seek out another Flanders Red/Brown. They are tart, refreshing, and unique. I put a list of interesting ones under 'alternate brews', and of course, the TN community will chime in with their own favorites as we do each week.
In the 'Week 3' article, I said:
"Beer is based on four ingredients: water, malt, hops, and yeast. These ingredients can be manipulated to produce very different end products by adjusting timing, volume of ingredients, and temperature. Brewers may add other ingredients including water salts, fruit, vegetables, herbs, spices, sugars, bacteria cultures, non-traditional yeasts, spirits, and wood aging to further change or complement the flavor profile. We'll cover some of these sporadically through the season, but start with the big four. All in all, the goal of craft brewing in my opinion is unique, well balanced beer."
This week, let's talk sours.
Belgium is sandwiched between France and Germany. If you think about the respective beverages in those regions, you can probably guess why the Belgians were as creative with beer as they were over the last few centuries. While the Germans rigidly upheld beer purity using only basic ingredients, and the French were, well, the French ("Je ne bois que du vin, oui oui!"), the brewers of Belgium were busy using unique ingredients to enhance the flavor. They added spices, herbs, interesting yeasts (recall the Saison in week 3), and bacteria. This is craft brewing at its best, only a lot of these styles were developed without the scientific knowhow brewers have today. Let's talk about sour beers in general, touch on a few styles, and whatnot. Then we'll cover the brew and get ready for game day.
Random tidbits:
A) Did you know: In the early 1800s and prior, breweries made beer by either letting yeast from the air ferment their wort or by pitching the yeast slurry left over from a previous batch into new wort. Thus, brews had a dominant yeast along with multiple yeast strains and other organisms in their cultures. In the 1830s several European chemists discovered that sugars were converting into alcohol during fermentation by microbial activity. The scientific community laughed at them, with some even writing satirical pieces about watching little cells eat sugar and poop out alcohol. Most prominent among the scoffers were several Nobel prize winning chemists. They strongly believed it was a yet undiscovered chemical process causing sugars to convert to alcohol.
It wasn't until the 1850s that the earlier yeast-make-alcohol discovery was accepted. Emil Hansen, head scientist at Carlsberg Brewery in Germany, managed to isolate a single yeast cell and built a pure culture. He convinced the brewery President to allow him to brew a batch using this single strain, and the interpretation of the results was unanimous: this was excellent beer. Rather than patenting the culturing process, the President convinced him to publish in an academic journal, making the information free to all. This time around, the scientific community accepted the findings (probably not too hard to convince them, just hand them a pint of the 'pure' brew along with the process). Within just a few years, most of the breweries in Europe were using pure strains for production.
2) Sour beers were probably pretty common in history, even if not intended. There are generally two types of acid produced by bacteria that contribute (acceptable) sour flavor to beer: lactic acid (from the bacteria lactobacillus, which are used in making pickles, yogurt, sauerkraut, kombucha, cheese, etc) and acetic acid (generally from acetobacter, used in the production of vinegar). These organisms are widely available in the air. Also, a strain of yeast called brettanomyces, which are found on fruit skins, are typical of some sour beers - they impart an all-around funky flavor with descriptors ranging from metallic to horsehair to ripe cheese. Sanitation wasn't always what it is today, so any of these little buggers could get into beer through barrels, recycled culture, the addition of ingredients after the wort boil, or within the brewery. Most of these are considered beer contaminants today if they show up out of context, but a number of classic beer styles, especially Belgian styles, feature them. And of course, today's craft brewers are looking for new ways to use them.
d) Sour ales can be classified as 'wild' ales, as they were traditionally fermented in open areas to allow wild bacteria and yeasts to enter the beer wort prior to and during fermentation. Some are still produced using these methods, while others have the 'wild' component introduced in controlled conditions in the brewery. Oud Bruin, meaning 'Old Brown' is the sour ale featured this week. Another major sour beer style is Lambic. Bottled Lambic is typically a mix of old and new beer, which can be further blended with fruit (Kreik, Framboise, etc), mixed with sugar (Faro), or blended without any additives (Gueuze).
The game day brew:
Flanders (or Flemish, since 'Flemish' means 'from Flanders') Oud Bruin hails from the Flanders region of Belgium, and the beer itself is a brown ale somewhat similar to a porter, with strong malt flavors and fairly neutral hop taste. However, Belgian yeasts and lactobaccilus are used to ferment the beer, giving it a strong sour character. Then they are typically aged in oak which adds to the flavor profile. Flanders Oud Bruin and Flanders Red are considered the same style of beer (Flemish or Flanders Sour), as the production process is much the same. The difference is probably where on the color spectrum the brewery puts their beer based on subtle differences in the malts used.
This beer is both tart and refreshing, but very different from other beer if you've never had one. I won't do a beer review here, as Flemish Sours available in the U.S. can vary from region to region and even at the same store on different days. The Monk's Café is a great example of the style. It is brewed by Brouwerij Van Steenberge N.V. specifically for the Monk's Café restaurant in Philadelphia, PN, but bottled and widely distributed in the U.S.
Alternate Brews - Let's discuss some other Flanders Reds/Browns that you can find if you can't get your hands on Monk's Café. There are a lot of options. Duchesse De Bourgogne - Brouwerij Verhaeghe and Rodenbach Grand Cru - Brouwerij Rodenbach N.V. are both exceptional for the style. And... well, we could go on, but see what your local beer store has. There are a number of American craft brewers who have taken on the style and are doing quite well with it. Feel free to venture into those as well.
What I'll (probably) Be Drinking Saturday - Monk's Café, Monstre Rouge from De Proefbrouwerij and Terrapin, Ass Kisser Porter Pounder (Smoked Porter), Cigar City Big Sound Scotch Ale, and homebrews.
What about you? What are your thoughts on Sours and what is your favorite? What will you drink on Saturday?
Previously reviewed brews:
Sept 01 - Murray State 6:00 p.m. (click to review this post)- Stone, Sublimely Self-Righteous Ale
Sept 08 - Savannah State 6:00 p.m. - Lagunitas, A Little Sumpin' Sumpin' Ale
Sept 15 - Wake Forest 12:00 p.m. - Green Flash, Saison Diego
Sept 22 - Clemson 8:00 p.m. - Southern Tier, Backburner Barleywine
Sept 29 - South Florida 6:00 p.m. - Cigar City Brewing, Oak-Aged Jai Alai India Pale Ale
Oct 6 - N.C. State 8:00 p.m. - Nøgne Ø, Imperial Brown Ale
October 13 - Boston College 6:30 p.m. - Samuel Adams, Octoberfest
October 20 - Miami 8:30 p.m. - Great Divide, Hercules
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5 Blogs You Should Be Reading
I read a lot of blogs. As of this writing, I have 90 blogs subscribed to in my RSS reader. Many of them update daily. A few multiple times a day.
At any time, I have between 100–200 unread blog posts.
As a blogger, it's something I have to live with. I have a lot of interests. The best way to keep up with the world is hear from a multitude of voices.
Over time, it becomes clear which blogs are useful and which ones are the same garbage over and over again. A few blogs have one or two amazing posts amid a sea of average.
Every so often, a truly exception blog comes out that teaches, is entertaining, and keeps posting quality content. Below are 5 personal finances blogs I have found to be well thought out, helpful, and entertaining:
- Personal Finances By The Book — Joe Plemon is one of my favorite personal finances writers. He asks good questions, challenges my presuppositions, and generally knows what he's talking about when it comes to finances. If you want to learn more about debt, investments, and how to handle money Joe is one of the best.
- Man Vs. Debt — Baker is a guy who woke up one morning and decided he wasn't going to be in debt anymore. So, his family sold almost everything they owned, started a website, and paid down thousands of dollars in personal debt. Oh yeah, and they did it while traveling around the world! His blog is interesting, his advice is sound, and he'll make you think. The only draw back? He hasn't been updating much recently. Still, I highly recommend his blog.
- Free Money Wisdom — This is a blog I just found a few days ago, and I already love it! Run by Jon the Saver, it goes deep into practical ways to handle money, invest wisely, and live frugally. I don't agree with him 100%, but I certainly support him 100%!
- I Will Teach You To Be Rich — This blog is even more provocative than the title. Run by Ramit Sethi, it chronicles his success in teaching people how to automate finances, live their dream life, and make more money than they ever imagined. He's pro-debt, but even his views on debt are sound.
- MoneyPlanSOS - Steve Stewart is a financial coach and podcaster. My favorite thing about him aren't his blog posts (though they good) but his podcasts. He has some of the smartest financial people on the web on their working through real-life cases and explaining the nuts and bolts of personal finances. He even asked me to be on his podcast.
Those are blogs you should follow if you want to get your finances in order.
Beyond that, I follow a list of financial blogs just to understand the world of money better. Here are a few of them below:
- Mint.com Blog — This is the blog of mint.com. I like the service they provide, but the blog can sometimes contradict itself and I don't always agree with the advice.
- Living In Financial Excellence — I really enjoy this blog, though sometimes I wish they would go deeper into some of their topics. Their podcast is fantastic and also has great guests.
- Debt Snowball Calculator — This missed the top 5 because of an odd update schedule. The content is amazing and his products are cheap and effective. Definitely worth reading.
What are your favorite personal finance blogs?


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Kristofer Bland was arrested at 2:15 a.m. Sunday, Feb. 2, and booked for investigation of continuous sexual abuse of a child and sexual penetration of a child under the age of 14, jail records show. His bail is $350,000.
Police opened the investigation at 11:20 a.m. Saturday.
"A parent reported overhearing a conversation between their child and a friend, in which acts of molestation were discussed," police said in a written statement released Monday. "The 14-year-old victim cooperated in the investigation and identified the suspect as her cheerleading coach.
"The coach worked for a private company teaching cheerleading."
Anyone with additional information may call police at 909-628-1234.


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Existing Drugs Fight Antibiotic-Resistant Bugs 110
from the choose-wisely dept.
I was thinking somewhat along the idea, written in summary. We could battle resistance with somekind of phasing of antibiotics in and out of use.. For example we could phase out one type of antibiotic for say decade, then bring it back and phase out another. Could this work?
The selective pressure to gain resistance is a lot stronger than the evolutionary forces to lose it when it's no longer needed, so I'm not sure that'd work on such short timescales.
10 years seems too long to me, actually. The problem is, a patient has an infection that's resistant to 'cillins or 'mycins or 'floaxins or 'sporins or what ever. Instead of throwing the biggest drug available at it (say it's resistant to all 'cillins) then throw something weak from another family (keflex or something on those lines). Don't throw Vanc/Gent at it, or Rocephin. But make sure the infection is dead dead. Not just in hiding and building a resistance to that new antibiotic too, treat with the full regimen and retest afterwards! And for gods sakes, drill it into the patients heads to take all X days worth, don't skip just because 'you feel better'!
Having just gone through this over 3 years, it's easy to say and harder to do. Bacteria hide (UTIs are bad about this, so are cysts), and when they do they can build up resistance and patients want the strong stuff so it kills it fast. But, and this is a bit of pt side talking, I wish I got the weaker meds first so the later infections weren't resistant to everything but Vanc/Gent/Strepto+Linazolid. Having on two drugs types available post-surgery (both 'of last resort' types) was a pain in the ass.
Second thing to do is for hospitals to be a little more cautious. Every antibiotic flavor for two years left my gut bacteria resistant to nearly everything. So, post surgery, and abscess appeared. Guess how many it was resistant to? Linazolid is the first antibiotic I've met that was more expensive, by weight, than gold. And that was the active drug weight, not the horse pill the crammed it in to!
For the curious, psuedomonas a started it and several idiot docs didn't call infectious disease to learn that omnicef and ampicillin wouldn't work; but they made everything else resistant. Then 4 PICC (well, 3 PICC and one PIC that got a little misplaced) for 3rd gen cefs' which are anti-psudo drugs. All the while, entero was getting resistant to all of those (lucky they killed all the e. coli or I'd have been toast).
> phase out one type of antibiotic for a decade
Nice idea in theory, but remember that infection types aren't monolithic. In your region, a given bacterium might have developed a strong resistance to amoxicillin, while in the next city over, they've become resistant to something else. Now add travel to the mix: a guy with methicillin-resistant germs flies across country, then shares his infection with the folks in that region.
NOW add in the fact that these things are most commonly spread in hospitals by overworked staff not washing their hands each and every time they visit a patient's room. One study I read several years ago found that the keyboards on the computers were loaded with MRSA, for example -- which could easily have been controlled with a puff of Lysol and a bottle of hand sanitizer.
At any rate, the article's premise makes sense to me. My doctor told me a few years ago that these things seemed to move in cycles: bacteria would became resistant to one antibiotic, then another
The cycle things still works, but will be more efficient if synchronized between all hospitals so that everyone phases out the same antibiotics at the same time.
What you want to do is essentially to on a global decide which medicine is least effective and stop using it until it becomes universally potent again.
Then you switch it out for the new least efficient until you have cycled them through.
New law, if you get an infection from the hospital, your stay is free. Just watch how fast they find the resources to sanitize everything.
Hey, we should set up a system that texts our doctors immediately when it is time to shift to different antibiotics, in order to combat the absolute latest resistant bacteria. Unfortunately we'll have to come up with quadrillions of $ of "support" funds to re-educate most of them from relying on Big Pharma for directions on what they should do (i.e. "Just keep giving out full-spectrum XYZocillin, it's grrrrrrrrrrr-eat!")
Don't use them unless they are necessary.
If only "pharma can't be bothered to create new antibiotics" were the issue. As it stands antibiotic development is a very active, very well funded private and public research effort. (As you'd expect from a field where whoever gets there first becomes unspeakably wealthy, there are an awful lot of startups.) It's just not turning up anything.
Carbapanem is the last I heard about. Finally got a dose of that recently, or it might have been carbenacillin...was post surgery, I had methadone, fentanyl, morphine, and lidocaine drips, my memory has a few holes. But you are right, the stuff being developed now is so strong that they kill human cells as easily as bacteria. It's almost like chemo drugs now.
Still need amikacin and a few of the 'penems to fill my punch card for antibiotics of last resort.
Seem quite simple, doesnt it? The fact that cattle, fish and shrimp feed in asia have huge amounts of antibiotics as a "preventive" measure to keep the animal from going sick, and the resistance the bacteria gain dealing in that sick field, and whatever trickles up the food chain doesnt seem to bother anyone, has long money is made. And nobody will care until it is too late. Big pharma also doesnt care, quite by the contrary the patents have long expired, and antibiotics are bought by the shovel, as soon as they stop working they will have then gov "fund" to further develop very expensive nanomeds. This seems like a stupid plot from a bad scifi movie.
This isn't just an Asia thing. You have described at exactly how food production in the USA works. I'm sure that there are other countries where it's the same. Food production in the USA is Big Business and Big Business always gets what it wants. What they want is zero loss and the way to achieve this is to use high amounts of pesticides that kill any bug that dares to get near produce and feed antibiotics to animals to keep them alive long enough to slaughter them.
What they want is zero loss and the way to achieve this is to use high amounts of pesticides that kill any bug that dares to get near produce and feed antibiotics to animals to keep them alive long enough to slaughter them.
Incorrect. What they want is to increase profits to the maximum amounts, and pesticides and antibiotics ain't cheap.A farmer is looking for the biggest yield for the lowest price, and wasting money on pesticides that aren't needed is not a good way to increase your profits. Farmers want t
Incorrect. What they want is to increase profits to the maximum amounts, and pesticides and antibiotics ain't cheap.
True, but antibiotics have the effect of making the animals gain more weight. The farmer can make more than the cost of the antibiotics back by selling more product, and so has an incentive to use them whether or not the animal is sick.
That attenuates the problem, but it doesn't stop it. Even those drugs that are limited to critical human medical uses are starting to run into resistance problems, and we're simply not finding new ones. The chemical space has become alarmingly barren.
Everyone knows Placebin is absolutely the most powerful anti-viral known to man. Give them that.
And if you are one of the many poor slobs whose health insurance is "go to the ER and hope they write off the check because I am in poverty and have no hope of paying it back"?
Recall that several congress critters cited exactly that scenario when they were debating against single payer health reform ("We already have single-payer health care, just go to your local Emergency Room!")
And if you are one of the many poor slobs whose health insurance is "go to the ER and hope they write off the check because I am in poverty and have no hope of paying it back"?
Most clinics are run by the same hospital systems that house your local ERs, so you get the same write off service there as you do going to an ER. And the ones that aren't are run usually run by companies that just won't see you without insurance or charities and have you pay as you can.
The thing about ERs is they have a much higher liability than clinics, and as such they must treat everything as a life or death situation & do EVERYTHING they can to make sure it isn't before they let you go, or have v
In TNG, Starfleet made it a regulation to alternate phaser frequences in order to fight the Borg. The Borg soon adapted to that strategy.
It would be strange for the bacteria not to adapt to the strategy of alternating antibiotics as well. It seems the bacteria have a very good pattern recognition mechanism.
Except that bacteria don't adapt to a "strategy". They adapt to the conditions at exist at the moment, with no consideration of the future implications of that adaptation. Because, you know, bacteria aren't intelligent.
Because, you know, bacteria aren't intelligent.
Have you considered that maybe it's you who just doesn't go to the kind of places the smart bacteria frequent?
Except that bacteria don't adapt at all (lacking freedom of will to do so and all). They experience random mutations that cause some of them to be better adapted to circumstances than others. If in hindsight some of those mutations happen to be really smart choices considering (then) future events, those bacteria will emerge as dominant because the other ones will have died.
Because, you know, that's how natural selection works
Actually it is a bit messier than that: http://en.wikipedia.org/wiki/Horizontal_gene_transfer [wikipedia.org]
So the genes for antibiotic resistance don't even have to be evolved by the same organism, nor must they remain there, they can spread separately from the pathogen. The germs you fight may not even be the main resevoir for those genes.
I actually wonder how long it will be before someone engineers a slutty bacterium that is very successful at gene transfer with its own kind and load it up with genes for antibiotic vulnerability. Hell it wouldn't even need to be a traditional antibiotic.... anything you can program it to recognize and trigger cell death should do the trick.
It would be kind of like air dropping syphlitic hookers on the enemy.
Fortunately, it's even messier than that: https://en.wikipedia.org/wiki/SOS_response [wikipedia.org]
This is the phenomenon the researchers are exploiting. Not every antibiotic resistance comes from a neatly-packed, horizontally-transferable gene; often, the bacterium is instead evolving alternatives to perform common tasks like the binding of ribosome cofactors. The most transferable antibiotic resistance genes are often enzymes that degrades the antibiotic. These can be overwhelmed; just hit the bacteria with several drugs at the same time. HGT of new-and-improved constitutive genes certainly still happens, but it's much less common, and may not be compatible across species. (As an extreme example, we only recently started finding cases where the ribosomal 16S gene was transferred, and both instances were within the same genus.)
So... there are definitely some strains, like MRSA [wikipedia.org], that have evolved to be ruthless killing machines, and these are particularly dangerous because their DNA can be taken up by other bacteria, but at present they represent a small percentage of all potential hospital-borne pathogens. They kill a lot (MRSA is believed to be the fourth largest cause of death in the US and kills over a hundred thousand people a year), but because the resistance comes from all of these key constitutive genes that have co-evolved, they mostly stay put. This is why a lot of research now focuses on preventing biofilm formation.
A perfectly valid analogy, in my objective opinion.
The biggest thing to make this work is that we need faster and cheaper detection of specific attributes of any bacterial infection. DNA typing is all well and good, but we still need to work on being able to attribute specific characteristics to a given strain. Something that takes less than an hour and $20 would be great.
I remember first proposing this back when I learned about phages - viruses that target bacteria. Thing is, they're much more specific to any given strain of bacteria than antibiotics ar
But when you have hours or minutes (or even a day, just long enough to get a culture and preliminary resistance check) to start treating a bacterial infection before septic shock sets in, DNA typing and creating a phage takes too long. The opposite problem is that if your first guess isn't 100% effective, than you also just upped the chance of training the bacteria to be more resistant.
It's not the standard e.coli UTI that causes resistances (chances are macrodantin or 'cillin or 'sporin will kill it good).
But when you have hours or minutes (or even a day, just long enough to get a culture and preliminary resistance check) to start treating a bacterial infection before septic shock sets in, DNA typing and creating a phage takes too long.
That's probably one of the best reasons to invest money into biotech research - to develop instruments and processes to squash the whole thing into a matter of hours at most. Compared to space colonization and similar projects, this one doesn't seem all that impossible (not to mention the usefulness and therefore desirability of synthetic organisms for other fields of human endeavor)- who would have thought in, say, the 1970's that whole-genome sequencing would a mundane affair one day? And it is now.
It would be nice, but designing a phage doesn't seem like a process that could be sped up that much
I think that in time, this will only be a software problem.
But making the phage and making it only kill what you want it to kill, there is your DNA scan for each different sample you make, and then for each sample of a good one that you get to make sure it didn't mutate in a bad way
I thought that this is how microbiological samples are studied today? At least I'm aware of virologists doing exactly this. You simply scan everything you have in the sample, and the computer sorts out the results into strains of whatever you happened to have there, including things you've never seen before. This is a nut for bioinformaticians to crack, not for medical equipment makers or for M.D.s.
a phage that doesn't die when it's target does
Phages can't "die" because they don't live, at leas
But making the phage and making it only kill what you want it to kill, there is your DNA scan for each different sample you make, and then for each sample of a good one that you get to make sure it didn't mutate in a bad way . .
One of the problems with phages is that they DO tend to be extremely specific, and it's not like a phage that targets bacteria is going to mutate to attack humans. Maybe your gut fauna, but even that's unlikely.
But then we run the risk of phage resistant bacteria, or a phage that doesn't die when it's target does; though if that meant enhanced immunity to a target bacteria for life, sign me up right away!
That's part of the fun, the phage mutates to keep up with the bacteria. It's like you're giving the infection the flu just before it's title fight with your immune system.
As for the phage, once the target bacteria is gone it'll probably be eliminated from the body pretty quickly - it can't repli
But when you have hours or minutes (or even a day, just long enough to get a culture and preliminary resistance check) to start treating a bacterial infection before septic shock sets in, DNA typing and creating a phage takes too long. The opposite problem is that if your first guess isn't 100% effective, than you also just upped the chance of training the bacteria to be more resistant.
That's why I said the #1 obstacle to this is speed of testing. You need a fast way, preferably under an hour, to test the infection and determine the best 'mix' of preventatives - hitting an infection with phages and antibiotics on top of the body's immune response should be an easy knockout on most infections, especially if you're specifically selecting for maximum vulnerability.
Using viruses as weapons against bacteria seems like an awesome idea, however, wouldn't a person's own immune system start attacking its ally the phage?
I mean, parts of the immune system, all they do is react to antigens, and phages would be seen as just another invader that doesn't belong, regardless of the fact that it is attacking a common enemy.
For this reason I'm not sure phage therapy would necessarily work.
It's my understanding that the Russians had some success with real world trials. Your body's immune system attacking the phage as well is indeed a concern, but so isn't it attacking the antibiotics.
The trick is that the virus is released after the bacteria, and while the body will eventually respond to it it should take enough time to take a good chunk out of the infection.
Designing them so the human body doesn't quickly generate an immune response against the phages would be a good trick though.
"*Big Pharma Companies* have been powerless to stop the rise of antibiotic-resistant bacteria and are increasingly desperate to develop novel drugs."
Here's a hint: Stop indiscriminately throwing antibiotics at everything that moves. It's precisely the over-use of these drugs that has created the problem in the first place.
Here's a hint: Stop indiscriminately throwing antibiotics at everything that moves. It's precisely the over-use of these drugs that has created the problem in the first place.
Why would pharmaceutical companies want to do that? As maximising profit presumably requires them to maximise sales of their products, and hence maximise usage.
It must be funny to make a new product that kills a living being and then see how in a matter of years the being evolves to be immune to your product or to bypass it in some novel way.
It must be great to understand that your amazing attacks are avoided by a system that requires no intelligence. That you're being outsmarted by the natural algorithm of evolution.
I've posted in this thread so can't mod you up now but very interesting! I knew silver had antibiotic properties but not copper. Only problem with copper is oxidation, requiring maintenance, which is possibly why they switched.
Yes. This is why household plumbing is largely copper. PVC is a little cheaper and easier to work with, but it doesn't have antibacterial properties so it should only be used on water lines where necessary.
Apparently, plumbers are smarter than hospital administrators when it comes to bacteria.
Probably not. Alloys tend to have different surface reactivity to their component parts. (Which is why you alloy iron to make stainless steel, of course...) Be interesting to try though.
The Navy has known the answer to that for centuries. Make the doctors and nurses that got caught not washing their hands polish it.
Over prescription of antibiotics is a huge problem here in Asia mostly due to cultural face saving practices. In the West when you go see a doctor you are sometimes, probably not often enough, told to just go home, stay hydrated, rest and that you don't need any medication because there's no medication that can really help.
In Asia however, when someone sees a doctor they expect to go home with something. Even though the doctor's advice is 'respected' it would be a loss of face for a patient seeking treatment to be told to just to go home and rest, no medication is needed. It's hard for Westerners to understand, and IMHO serves very little purpose in today's society, but Asians would view coming home from a doctor without medication as the doctor not doing their job. Also, by not providing some kind of medication the doctor is basically, in the Asian mind, telling the patient "you are wrong, there's nothing wrong with you" which would be a big loss of face for the patient.
There's also a cultural service and purchasing custom that applies but it's much more esoteric and difficult to describe. Briefly, there's an expression "buy 10 buns, get 11 bags" because everyone is conditioned that a transaction is not complete until the goods or services are delivered well and completely packaged. It's a nice polite custom and all but you should see the dumbfounded look on many vendors' faces when I tell them I do not want a plastic bag for my purchase(s). It may sound irrelevant but it comes into play at the doctor's office in terms of, the service transaction is not complete until medicine is delivered.
So, doctors here are not able to go against the cultural grain, even though they know medically and scientifically that antibiotics will do more harm (in the long run) than good, the cultural conditioning is too strong so they always prescribe and 9 times out of 10 it's antibiotics. I was a paramedic in the US for years and I know treatments are highly relative to cultures. I've got no problem with cupping or coining or other 'treatments' that appear to be absurd when viewed through the filter of my culture but, none of those practices have an international impact.
Over prescription of antibiotics is a very significant international problem and Asia is doing the world a huge disservice by allowing it's cultural customs to influence medicine to such a degree in this matter.
Already-useless antibiotics are an excellent placebo in that situation, side effects notwithstanding.
That happens in the US too, particularly from the wealthy (if you don't have the money to pay for 'em, you won't be fishing for meds -- at least not antibiotics!) I used to know someone who would call their doctor every time they got a cold, and the doctor would phone in a prescription for Azithromicyn [sp?] to the pharmacy without ever even seeing them...
OK, but that does not really seem to be the main issue here. If the doctors needed to proscribe anything, they could proscribe some vitamin C or whatever.
Doctors have dozens of alternative general medications that would do less damage than prescribing antibiotics.
Indeed, they should!
I should have mentioned in the OP that education on issues like this is severely lacking here. So, from the patient's POV, I think there's an expectation of antibiotics for 2 reasons. Today people are used to getting them for everything and there was a time when they were thought of as a cure all / wonder drug of sorts and that thinking persists. I know far more about the challenges doctors face around this issue than I do about patients' expectations. However, I'm confident a controlled
Aside: face [wikipedia.org] is actually a very translatable concept that most educated Westerners understand easily; it mostly seems to be cultural anthropologists who are convinced that it's hard to understand the consequences of being embarrassed in front of important people to one's social status. (Maybe they don't remember giving their thesis defences?)
Joce640k really hit the nail on the head. Not only does this problem exist in the English-speaking world as well, we developed a whole class of drugs just to deal with d
I thought they figured out long ago that multiple antibiotics simultaneously, especially ones with different mechanisms (such that two, not one, mutation would be required, and thus infinitely less likely to happen) was the way to go, and the only thing slowing them was stacking side effects.
If not, sorry, my bad. I should have published something in the mid 1990s when this first occured to me. Sorry dead people
This research is interesting because it makes headway where one mutation increases sensitivi
The only drug that actually works. And I don't mean it's derivatives. Unless you are allergic to it, it's still the best drug on the market. If I have a bad cold I can shed it within 8 hours or so as opposed to something like amoxycillin which takes days at best. But since it's dirt cheap the drug companies are pushing "modern" drugs at a premium and telling you they are better.
Perhaps drug researchers can find a way to allow the original organism in some antibiotic sources, say penicillin mold, to react to the evolved bacterium, thus changing its antibacterial toxin naturally as it must have done for millions of years to keep ahead of whatever was trying to consume it. Could we let nature battle the evolving immunity issue naturally? Large tanks of naturally acquired, say penicillin mold again, with its natural genetic variations placed in close proximity to the antibiotic-resist
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I've had 2 children attending PSR since they were in the infant center (6 wks to a year). Which is a separate buildings from the older children (separate buildings). Another great positive is that it s on a private road & if you don t have business their then there is no need to be traveling down to PSR. The 8= acres allows the kids extra educational activies. The teachers have been very attentive to my kids needs and is always willing to go the extra mile. The lunches are nutritional & the teacher all have longevity. I could not praise this school enough.. Your children will enjoy going to Post Sunshine Ranch too.
My daughter LOVES every moment at this school. She started on her second birthday after a not so wonderful experience at a local daycare. I never gave children enough credit in learning until I saw how much she learned at PSR. I know that the teachers at PSR gave her the proper foundation to succeed. She is now in 3rd grade and still manages to teach other things she learned at PSR. My daughter still attends the summer program with PSR and I know that she is in safe hands even though I am 750 miles away. I know that she is provided with proper nutrition, great experiences, educational challenges, and most of all given loving care. I would HIGHLY reccommend PSR to anyone seeking care for their child/ren.
My daughter has been attending Post Sunshine Ranch since March of this year. And she has learned so much more in that short period of time. They were what I was looking for in a daycare-meals, more children in a room, outside play, activities and learning. The staff is great and they try to keep each other informed when they switch out. I would recommend this daycare to anyone!
Post Sunshine Ranch is a excellent pre educational school. My daughter has attended there since she was one and the staff have been great. I know that when she is in kindergarden she will be ahead of the game as far as academics becuase of the level in which is being taught at this school. The staff has been very helpful in this stressful time for both my daughter and I and the separation of her father and I and is always there to answer whatever questions. They care about both of our well being and are forward to let me know what is going on in in her world. I am blessed to have found them for our daughter.
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Box Office Opens March 11 for Broadway's Starry The Trip to Bountiful
By Andrew Gans
The box office for the Broadway production of Horton Foote's The Trip to Bountiful, which will begin previews March 30 the Stephen Sondheim Theatre, opens for business March 11 at 10 AM ET; the theatre is located at 124 W. 43rd St.
As previously reported, the cast will feature Emmy winner Cicely Tyson, Academy Award winner Cuba Gooding Jr. ("Jerry Maguire," "Red Tails"), Emmy Award nominee Vanessa Williams ("Ugly Betty," "Desperate Housewives"), Tony Award nominee Condola Rashad (Lifetime's "Steel Magnolias," Broadway's Stick Fly), Tony nominee Tom Wopat, Devon Abner, Curtis Billings, Pat Bowie, Leon Addison Brown, Arthur French, Susan Heyward, Bill Kux, Linda Powell and Charles Turner.
Directed by Michael Wilson and produced by Nelle Nugent, the 14-week limited engagement will officially open April 23.
"For years I have been searching for the perfect project to bring me back to my true home – the stage," said Tyson in an earlier statement. "In many ways Broadway is my Bountiful and I'm eager and honored to return with this strong, passionate, and funny character in a timeless American classic."
"The Trip to Bountiful is among Horton's most beloved plays, and Carrie Watts, one of his most memorable characters. To do the play and role justice, you need an actress of rare stature and command," added director Wilson. "Cicely Tyson has, over the span of a distinguished career, depicted iconic Americans engaged in immense struggle. Her legendary performances – from Jane Pittman to Coretta Scott King to Harriet Tubman, to name just a few — have contributed mightily to our sense of national identity and character. I am thrilled that she is returning to the stage now to have her trip, to lead us all on a journey that promises to be unforgettable."
The Trip to Bountiful, according to press notes, tells the story of "Carrie Watts (Tyson), an elderly woman who dreams of returning to her small hometown of Bountiful, TX one last time, against the wishes of her overprotective son (Gooding) and domineering daughter-in-law (Williams). Her journey becomes a heartbreaking but ultimately life-affirming and inspiring tale that examines the fragility of memory and celebrates the enduring power of hope and faith."
The Trip to Bountiful premiered as a teleplay on NBC in 1953, starring Lillian Gish as Carrie Watts. The play had its Broadway premiere later that year with the same cast, which also included Eva Marie Saint. The play was adapted by Foote into an acclaimed 1985 film starring Geraldine Page, for which she won the Academy Award. In 2005, Signature Theatre produced the play Off-Broadway starring Lois Smith, for which she won Lortel, Obie, Outer Critics and Drama Desk Awards.
The Broadway creative team will include Jeff Cowie (scenery), Van Broughton Ramsey (costumes), Rui Rita (lighting), and John Gromada (original music and sound design).
Tickets are currently available by visiting Telecharge.com. For more information visit www.TheTripToBountifulBroadway.com.
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The Reno Police Department is asking for help finding the man that robbed a hotel near Wooster High School Wednesday night.
RPD is looking for a white man in his 30's, about 5' 10" with a medium build. They say he walked into the La Quinta Inn on Market street in Reno around 11 p.m. Wednesday, wearing a dark hoodie and dark pants. They say he pointed a gun at the desk clerk and demanded money. She gave him an undisclosed amount before he left on foot.
If you have any information, you are asked to call Secret Witness at 322-4900 or you can text your tip to 847-411 keyword SW.
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Mailing Address:4925 Energy WayReno, NV 89502


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TROY, N.Y. - The City of Troy made a step to take back their community from graffiti Thursday night.
"We know graffiti multiplies so it can't stay," said City Council Woman Nina Nichols.
Currently in the City of Troy there is no law that requires property owners to remove graffiti, but Nichols says that is about to change.
During Thursday's Finance Committee meeting legislation was passed that would require property owners to get rid of the graffiti within one week.
"We don't intend to make the property owner a victim when they have already been a victim by the graffiti," said Nichols.
Under the proposed ordinance, property owners will have seven days to remove the graffiti. They have the choice to paint over it themselves or give permission for the city to do it.
"The city will come out and public works will cover over it with white exterior paint we're offering to do for free," said Nichols.
If the property owner doesn't comply with the law within a week they will be fined $10 dollars a day every day the graffiti remains.
The city says it's not just about beautification, but safety and pride.
"When you clean something up you also set the dominos falling for taking back your neighborhood," said Nichols.
According to Troy Police, graffiti is one of the most common ways gangs identify themselves.
"We have a lot of issues we feel are spurred on by graffiti and one led to a violent episode a few years ago and we are trying to prevent that in the future," said Police Chief John Tedesco.
The proposed ordinance is scheduled to be voted on by Troy City Council during the September 6th meeting.
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Arson attack at derelict Dudley pub
9:22am Saturday 25th August 2012 in News
ARSONISTS have set fire to a derelict Dudley town pub.
Fire crews from Dudley, Tipton and Brierley Hill were called to the disused Gipsies Tent pub on the junction of Steppingstone Street, at around 4.27 yesterday (Friday).
The incident involved a severe fire in the ground floor front room of the two storey empty building, with 100 per cent of the room engulfed in flames.
Firefighters used breathing apparatus, two hose reel jets to quell the flames and ventilation fans to clear the smoke.
No persons were found following a thorough search of the building and the incident is being treated as arson.
Firefighters left the scene shortly before 6pm.
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Inconsistency isn't such a terrible thing if you can predict when both the good and bad will occur.
If you play in yearly fantasy basketball leagues, an inconsistent player isn't so terrible as long as their overall numbers are solid. If you play in daily fantasy sports, it can be the worst. Not being able to trust a specific player will cause you to avoid him on many occasions when he may be usable. The Suns have a variety of these "difficult to predict" players but none more so than Channing Frye. I always say he's hard to trust but I have never really glanced over the numbers. The point of this article is to determine whether there is a method to the madness that is Channing Frye. Are there certain matchups or teams that spark his monster nights or is it all dependent on whether he is feeling the shot on a given night? Does he succeed against above.500 teams or below .500 teams? Do teams with larger, unathletic big men help him get open above the three point line? I had all these questions going into this article and it was time for answers.
The first place I started on my quest to make sense of Frye's numbers was his seasonal splits. Sticking out to me immediately was his home vs. road splits. Frye averages almost one full point more at home with a 4.1% better shooting percentage (47.6-43.5). He actually takes fewer shots at home but produces more points. Three point percentage was even larger of a discrepancy: 45.6% at home as opposed to 38.3% on the road. Strangely enough, he averages exactly 2.3 3PM both at home and on the road. As I looked back to 2011 (his last full season in the NBA because he missed all of 2012-13), Frye averaged over 2.0 PPG more at home and also averaged a better FG%. So undoubtedly, without much research needed, it appears Frye's matchups are much tastier at home.
I don't put much stock into certain statistics but sometimes coincidence is too much to overlook. When looking at his splits from starting vs. coming off the bench, his starter numbers were head and shoulders better. Then I realized he has only come off the bench for one game this season and had three points in the game. Cross that theory off the list. There are actually statistics that keep track of stats by days of the week. This year, Frye is by far the best on weekends (Saturdays and Sundays). On those two days, he averages 49.3 and 52.8% FG respectively and over 3.5 PPG more than his season average on both. After I noticed this trend, I cycled back to his 2011 numbers and those were two of his worst days of the week. I also noticed he only has a combined 12 games on those two games this season. I'd be hard pressed to put any stock into the days of the week theory.
Now, onto the theory I really wanted to look into: analyzing the actual teams he has excelled against this season. Let's look at the teams that Frye has scored the most against so far this season:
1. Minnesota: 1 GM, 22.0 PPG
2. Detroit: 1 GM, 21.0 PPG
3. Oklahoma City: 1 GM, 19.0 PPG
4. Milwaukee: 2 GM, 17.5 PPG
5. Cleveland/Miami/Washington tied at 16.0 PPG
These are kind of a strange assortment of teams to have success against. Of those teams, only two are in the bottom ten of fantasy points allowed per game to the power forward position (MIL, OKC). Strangely, the power forwards on those teams couldn't be much different. Ilyasova avoids physicality and doesn't impose much on defense. Ibaka, a talented defender and athletic freak, takes chances on blocks but will also body up his man at any given time. Just singling out those two, I saw nothing that could be solid evidence of what Frye liked about them specifically. So I took a look at the build of the starting power forward on each the eight teams Frye has torched this year:
1. Kevin Love – 6'10, 260 lbs
2. Greg Monroe – 6'11, 253 lbs
3. Serge Ibaka – 6'10, 220 lbs
4. Ersan Ilyasova – 6'9, 235 lbs
5. Tristan Thompson 6'8, 225 lbs/Chris Bosh 6'10, 228 lbs/Nene 6'11 260 lbs
A trend emerged that I had somewhat suspected from the beginning. Aside from Ilyasova and Ibaka, most of these guys have some experience playing center in their career. Whether it was Kevin Love/Thompson playing some in college or Bosh/Monroe/Nene starting there earlier in their career, most had played there at some point. Due to experience of guarding bigger players, I can understand how adjusting to stretch four like Frye may be difficult. Love was a center at UCLA and was about 30 lbs heavier. Since losing weight, he has not yet adjusted into a great defensive player. Greg Monroe was the starting center before Drummond came to town, Nene started at center on Denver and Bosh started there on Toronto for years. Most of the players that they faced off against were physical beasts. Having to step out on Frye to cover the three is not something they are used to. For that reason, it seems Frye has some form of better success against bigger, less experienced defenders.
So is there something here? Maybe, I still think this is too small of a sample size. All I know is you are better off playing Frye in a situation where he goes against a bigger team. He's not really a rebounder as-is, so when you play him, you are relying on points and threes. He'll have a better chance of hitting threes against a big that has a hard time getting out on him; one that is used to defending the post. If you see a big oaf coming up on the schedule that mans the power forward position, then look to put Frye in your lineup at that time. Beyond that, Frye will continue to give you headaches with when he decides to step up. Really, trends are still just educated guesses. Sometimes the hot hand really just prevails over all. For my money, I'll bet his hot hand happens most against big power forwards at home.
For more Phoenix Suns stats, news and rumors, visit Fantasy Basketball Money Leagues


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As the holiday season begins so do the traditions. But for many, the tradition of cutting down the Christmas tree was axed not because of the grinch, but rather mother nature.
Steve and Mary Gaardner made the trip from Joplin to Bowen's Christmas Tree Farm in Pittsburg intending to cut down a Christmas tree, something the farm has offered for 28 years. But not this year.
"We always go out and find a tree farm we can walk around a little bit look at the trees and cut the trees down. These are good looking trees but it is a fun experience I guess if we had our kids with us today we would have found someplace to cut them down because they love doing that" says Steve & Mary Gaardner.
But there are very few trees in the field that could be cut.
This has grown since the last rain a month ago this tree could probably be sold today but we decided not to sell any of them. Jim Bowen is the owner of the tree farm.
He says the drought has killed more than 400 trees that were planted in the spring and effected the height of hundreds more..
"We haven't had any real growth out of the trees that we had out here in the field that we planted grew couple of inches in the last 2 years so we are going to have to go through and shape those all up and start them over" says Bowen.
Bowen says these trees should be around 24 inches tall. If the lack of rain continues, it would take up to 8 years for some of these trees to reach the 6 to 7 ft mark. But trying to be optimistic Bowen hopes it will be the last time he has to ship in more than 500 trees from places like Wisconsin and Minnesota.
Though the process of picking out their tree was a little different this year the Gaardners hope to come back again next year saw in hand.
The Bowen's say on the bright side of bringing in trees from out of state, they are able to offer a wider variety of trees they are not able to grow in the warm Kansas climate.


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Apple's panels / Samsung, Sharp, and LG
I curious about the panels Apple uses for all their iOS devices including the new iPad.
Here are the questions I have:
Does Samsung make the screen for the new iPad?
Can Samsung use the same panel that the new iPad uses in another device? (On a galaxy tab or something similar)
Who made the screen for the iPad 2?
How come no one using the same panel in the iphone 4s? Is it legally only for Apple?
Was the screen for the 4s a different manufacturer than the 4?
Why did the ipod touch not have the same screen as the 4?


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by Daniel Finnan
Article published on the 2009-09-16 Latest update 2009-09-16 14:59 TU
A weapons system fired by Israeli forces explodes over the Gaza Strip during the conflict
(Credit: Reuters )
The report, which was the result of a fact-finding mission led by Justice Richard Goldstone, concluded that there is evidence of Israel committing "serious violations of international human rights and humanitarian law" and that Palestinian armed groups "committed war crimes, as well as possibly crimes against humanity, in their repeated launching of rockets and mortars."
Within its 574 pages, the report describes deliberate attempts to cause loss of life and injury to civilians and damage to civilian structures, calling Israeli action, "disproportionate" and condemning rockets fired from Gaza which "have caused terror in the affected communities".
Although the fact-finding mission was restricted by Israeli officials, analysts have praised its comprehensive approach, despite the lack of any clear path to justice.
"Despite being denied any cooperation by the Israeli authorities, they nevertheless managed to produce a very, very thorough report that looks also quite beyond the war itself, and the underlying causes of the war," analyst Mouin Rabbani told RFI.
"I'm not optimistic that there is going to be genuine accountability for this war," he added.
The reports recommended that Israeli and Palestinian authorities launch independent investigations into the alleged war crimes to be assessed by the Security Council. It then suggests that if the Security Council is not satisfied, the matter should be referred to the International Criminal Court.
"I think given their options, the report's authors chose the best one available. The problem of course, is that the Security Council is hardly a disinterested arbitrator or observer," said Rabbani.
Both sides have criticised the conclusions of the report, with Israel claiming that it would challenge the report diplomatically, and Hamas saying it was defending Gaza against an occupying force. They also called for Israeli leaders to be put on trial.
As talks between Israeli Prime Minister Benjamin Netanyahu and US Middle East peace envoy George Mitchell remain deadlocked on the issue on settlement construction, it is not clear whether the report will have any significant implications.
"One would hope that these kinds of reports will help underline the reality, that if there is going to be a durable peace in the Middle East, the implementation of international legal principles, and respect for the fundamental principles of international law, have to be at the core of any such peace," Rabbani told RFI.
Details of the report:
Four contributors


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text: Zack Grienke will be a Royal in 2013. As i told my friends Zack Grenike will be a Royal in 2013. He spoke with GM D Moore and said trade me to a contender, get some help and when my contract is up in two years, I'll come back back to KC to contend for a championship when all the youngsters are up and ready to go forward. It is happening now and next year with he addition of Greinke and another starting pitcher, the Royals will be contenders for the next several years. I'd said this and I believe that this will happen. It is all part of plan. Go Royals!!!!!!


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Fateh Nama Letter of Victory:
The Guru composed a letter of 24 couplets titled Fateh Nama addressed to Mughal Emperor Aurangzeb. Proclaiming victory even though he had lost two sons in the Chamkaur massacre of 40 Khalsa warriors against a Mughal horde of thousands, the Guru rebuked and challenged the emperor to join his troops and meet him face to face on the battle field.
Daya Singh carried the letter for delivery masquerading as a Muslim Fakir transported in a palanquin by Dharam Singh, Man Singh and the Khan brothers disguised as his dervish devotees. They were detained at village Lal where a suspicious Mughal officer contacted Qazi Pir Mohammed of Sohal, an instructor who had schooled Guru Gobind Singh in Persian, to check the identity of the travelers. The Pir verified that the Guru was not among them. They were allowed to precede, and traveled to Gulal with the Pir where Guru Gobind Singh had pre-arranged to meet them and awaited their arrival.
Hukam Namas Letters of Commendation and Praise:
Guru Gobind Singh thanked the Pir and rewarded him with a Hukam Nama, letter of commendation, and sent him safely home.
The Guru visited various towns and villages. He stopped in village Silaoni with an Udasi who shared the name Kirpal Singh with his master who had fought along side the Guru in a previous battle at Bhangani. Here the Pathan horsetraders parted ways with the Guru, who presented them also with a Hukam Nama letter praising their service to him.
Zafar Nama Letter of Triumph:
Raikala visited Guru Gobind Singh in Silaoni and asked him to come to his home in Rai Kot. The Guru went on to Rai Kot where at his request Raikala dispatched Naru Mahi to inquire the whereabouts of the Guru's wives, mother and younger sons. The Guru remained with Raikala for about 16 days. During that time, the Guru learned that his wives had been sheltered in secreted in Dheli with Bhai Mani Singh, but that his mother Gujri and youngest sons Sahibzade Zarowar Singh Fateh Singh and had been captured and martyred at Sirhind. He also received news that Anup Kaur, a young relative of his wife Ajit Kaur (Jito), had taken her own life rather than succumb to the advances of her captor Sher Muhammad of Malerkotla.
The Guru made his way around the countryside evading the Mughals while visiting sympathizers and supporters in various villages and townships. While in Alamgir, he met with Nagahia Singh, the son of Kala and elder brother of Bhai Mani Singh, who provided him with a well bred horse. The Guru then arrived in Dina where he rested, recouped and received another high caliber mount from a staunch Sikh named Rama. Many devotees came to see him and pledge their allegiance, others came to hear his divine message.
While in Dina, the Guru revived an arrogant reply from Mughal Emperor Aurangzeb proclaiming himself the sole secular and religious authority of a singular kingdom, and the Guru to be a mere subject of his. Guru Gobind Singh responded chastising Aurangzeb for his vile tyranny and treachery, and reproaching him for the merciless slaughter of innocents including the Guru's own young sons. The Guru communicated in the Persian language using metered verse in a composition of 111 stanzas titled Zafar Nama. He praised the valor of Sikh martyrs who laid down there lives fearlessly though vastly outnumbered at the Chamkaur massacre, and described the his courageous feats of own martyred son's, the Sahibzade Ajit Singh and Jujhar Singh. Inviting the emperor to come and sort things out with him, the Guru wrote,
"Chun kar az hameh heelatae dar guzasht
Halal ast burdan ba shamshir dast
When strategies exhaust all means of employing the word,
It is righteous to negotiate by raising the sword."
(Sikhism.About.com is part of the About Group. For reprint requests be sure to mention if you are a non-profit organization or school.)


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On Friday, the U.S.-led coalition in Afghanistan distributed footballs as part of its "hearts and minds" campaign to win over "support from the local population." But the footballs instead "kicked off a storm of protest" because they were illustrated with the flags of several nations, including bearing "Koranic verses as part of the flag of Saudi Arabia." Protestors said it was "insulting for texts from the Koran to be put on the ground and kicked."
'Hearts and minds' campaign insults Afghans.
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How do air molecules rebound?
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Aug25-08, 03:35 AM
Hi, so glad to be here. This is my first posting. I'm just a 61 year-old dummy, so please help!
If a rubber ball is dropped to a hard surface the impact will compress the rubber, storing some of the kinetic energy as potential elastic energy. The rebound will come from this stored potential elastic energy. If the ball is dropped straight down I presume this elastic force is stored in the ball mostly in an axis normal to the ground, ie. the ball is smushed out making it just a little fatter at its' "equater" than at its' poles (the axis of impact).
If I've got this bouncing ball thing right so far, can this idea of storing potential energy mostly along the axis of impact be carried over to air molecules? Do air molecules impacting a surface, like the walls of a containing vessel, hold potential energy (for the rebound) mostly in the axis of impact (normal to the impact surface)?
Let's change the world.....does anybody out there know the answer?
Thank you in advance!
Aug25-08, 04:23 AM
Sci Advisor
If a ball rebounds from the ground perfectly (ie. rebounds to the same height from which it was dropped), then all the energy of ball is completely kinetic just before and just after it hits the ground. The point at which it hits the ground is complex, and perhaps potential energy is stored in the material of the ball for a very short time. So if there is potential energy stored in the material of the ball, it is only at the point of impact.
Just after impact, the energy of a perfectly rebounding ball entirely kinetic. As it rises in height, the kinetic energy is converted to potential energy - but this potential energy is not stored in the material of the ball, it is stored in the ball by virtue of its height in the gravitational field.
So it's the same for an air molecule, any potential energy stored by "compressing" it occurs only at the point of impact with the walls of the container or with other air molecules. It's a good first approximation to think of the energy of air as entirely kinetic. A tall column of air has potential energy, but again, that's just because things held high above the ground have gravitational potential energy.
Actually, it's not clear that the smushing (away from the axis of impact) of the material at the point of impact aids a perfect rebound. If the compression occurs in the wrong way, then some of the kinetic energy of the ball is converted into heat, so the ball will rebound to a lesser height, but will feel slightly warmer after the rebound. Heat is the vibration of the material of the ball in random directions, so for there to be no loss of energy as heat, you are right that the compression should be along the axis of impact.
Another way to get a perfect rebound is to make the ball of material so hard that it cannot have any internal compressions or vibrations at all, so it can never be heated up. You should also make the ball very small, because internal rotations will take away from the rebound. If you use a perfectly hard material for your ball, you still may not get the perfect rebound, because the ground must also be perfectly hard for that to work. So this is very impractical, and I think only theorists use such prefectly rebounding balls.
Aug25-08, 06:46 AM
HW Helper
A better analogy might be the fully elastic interation of two opposing magnets approaching each other on a firctionless surface. They will not physically collide, but there will be a collision like reaction, with preservation of momentum and of kinetic energy. Even without a collision, the opposing forces will result in a compression at the inner surfaces of the two magnets.
Regarding the relastionship between speed and temperature:
There's a really neat mathematical equation based on a theorem called
the "equipartition theorem" which states that the energy of a gas system
(equal to 1/2*mv^2) is equal to the temperature of the gas (equal to 3/2*kT).
If we rewrite this equation to solve for velocity we get:
sqrt(3*T*k/m) = v
where T is the temperature in Kelvin, k is the Boltzman constant = 1.3805*10^-
23 J/K and m is the mass of the gas particle.
If we assume that the average mass of air (since it is a mixture of different
gases) is 28.9 g/mol (or each gas particle is around 4.799*10^-26), and room-
temperature is 27C or 300K, we find that the average velocity of a single air
particle is around 500 m/s or 1100 miles per hour!
Note that this average speed of air molecule is much faster than the speed of sound
at a specific temperature, since the speed of sound is based on the speed of propgation
of collisions, instead of the speed of the molecules. At 27C, the speed of sound in
the air is 347 mps or 777mph.
Aug25-08, 10:30 AM
How do air molecules rebound?
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Filing an Internal Complaint with the College: Pressing Charges with CollegeThe College encourages you to file a complaint with the Dean of Students office for formal adjudication and the Title IX Coordinator or members of the Dean of Students Office are prepared to work with you to make sure you understand the process and to see that any pre-hearing accommodations such as a no-contact order, change of room, or classroom accommodation are put in place. They can also discuss accommodations for the hearing that preserve the right of both parties to hear and respond to testimony but allow for physical separation. The College can pursue a complaint as long as the accused is still a student, administrator or faculty. The College will conduct an investigation in advance of any hearing.Dean of Students Fred Alford; Associate Deans: Ann Reuman and Christopher Card, 860-297-2156 * Hamlin/Cook
Filing an External Complaint with the Hartford Police: Criminal ChargesThe college encourages you to file a report with the Hartford Police. You have five years from the date of the incident to file in Connecticut. A member of Campus Safety, an Administrator on Call (AOC) or a WGRAC staff member can accompany you to make the report. Evidence can be used from the "post-evidence collection kit" (see bottom of page) if the person had one within 72 hours of the incident, at Hartford Hospital.
Anonymous Option: Filing an Anonymous Report:This link offers an anonymous reporting site for all violations of Trinity College policy including sexual assault, rape, stalking, relationship violence and sexual harassment. This report will be sent to the Title IX Coordinator.http://adsvm26/cesireportexec/olr/OLRMain.aspx?IsAuth=1&groupid=102
Confidential Option: Speaking in Complete ConfidenceThe Counseling Center, Chaplains and 24 hour hotline staff have privileged communication, meaning you can disclose to them in complete confidence.
SART Option: Reporting to a SART MemberStudents can speak to a SART member to receive support, guidance, referrals, and information. SART members are trained in victim and survivor response. Your report will be documented – listing your name and the accused's is optional. The report will be used to inform or generate the statistics on campus crimes that we are required to report in compliance with the federal Clery Act. There is a Department of Education requirement that Trinity investigates all complaints/reports and attempt to do so to the extent practical and possible even if names aren't listed in the report. A student who wishes to bring a complaint against a member of the administration/staff or faculty should consult the dean of students office or the dean of faculty: email@example.com.
Campus Safety will provide transportation to Hartford Hospital for this exam. You can bring a friend, and an AOC can accompany you. The AOC can call an advocate from the rape crisis center if you wish. You need to have the "kit" performed within 72 hours of the assault; a "kit" can take up to 4 or more hours. The Health Center can also test for "date-rape" drugs if you do not want to go to the hospital. Please contact the Health Center at 860-297-2018 or speak to your Area Coordinator for more information.


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by Nick Delgado
Guam - Three members of the police force appeared in court today asking that they be released from jail as their defense attorneys maintained their clients' innocence in the blue house brothel. Officers David Q. Manila, Anthony Quenga and Mario Laxamana appeared in court today asking once again to be released from jail.
The officers have been behind bars since they were picked up by Superior Court Marshals last Friday night following a superseding indictment that accuses them of conspiring, promoting and furthering prostitution at the former Blue House Lounge. Manila also two counts of first degree criminal sexual conduct for allegedly sexually assaulting two workers at the bar. Attorney William Pole represents Manila and argued that his client should be released on his own recognizance or alternatively be placed on house arrest to a third-party custodian.
He said, "He is a veteran officer, he has a house on Guam, he has a pregnant girlfriend who is due to give birth in a month and children from his first marriage is here and on all of those reasons he is not a flight risk. He has always been open and honest with the government as well as with the prosecution so again the argument that he is now (guilty) after four years of open cooperation with the federal government has not been shown."
He added his client was a key witness in the federal case against club owner Song Ja Cha in which he admitted to paying for a drink and then having sex with a worker at the Blue House in a VIP room.
Prosecutor Nelson Werner painted a different picture, saying the victims, nine of whom are still on Guam, are still living in fear. "We have women who are intimidated and forced into prostitution and as I pointed out in my brief that intimidation went on yesterday in this court room by defendant Quenga, and we have real concerns that if these gentlemen are released and can go out on their own recognizance and further the intimidation that started a number of years ago, it will jeopardize the government's case," he said.
GPD officer and FBI task force member Tracey Volta was called to the stand to testify about the interviews that were conducted with 16 victims in the case, one by one naming them.
Volta said they said, "that they were afraid of the police and still concerned," adding that the nature of their concern was, "retaliation by the police department against them."
Attorney Leevin Camacho who represents Officer Quenga questioned Volta about whether there was any evidence that his client contacted any of the victims. Officer Volta replied "not to my knowledge." Volta said the investigation began in October of this year when the police department was ordered by the governor to further look into allegations of police involvement in the prostitution that occurred at the blue house.
The hearing grew emotional for Officer Laxamana, who was seen wiping tears from his eyes in the courtroom as his attorney, Peter Perez, detailed why his client was not a flight risk. Perez also said the likelihood of conviction is very minimal. "The point is they are asking for an excessive bail, they are grandstanding, the matter in which they are handling Mr. Laxamana's case is not fair," he stated, adding, "The court is not going to be bothered by this rush to judgment in the public and this political posturing by almost every branch of government except the Judicial Branch regarding this case, but thankfully we are in a dispassionate forum of restraint."
The prosecution says the bail amount is a result of the multiple conspiracy charges. Werner also told the court discovery will be handed over to the defense by Friday and only then, he says will they know the strength of their case.
Both Laxamana and Quenga have approved third party custodians in the event Judge Anita Sukola grants their bail motions. The motions were taken under advisement with Sukola expected to render her decision by Friday morning.
During the federal trial, several of the workers testified that police officers frequented the establishment and were "friends" of the owner.
It's alleged that the officers were used to prevent the girls from leaving the establishment and to make threats to force them to perform sexual acts for officers and customers who paid for it.
Meantime, Freda Eseun pleaded not guilty and is on pre-trial release. Cha's arraignment, however, was continued until Friday when the court is expected to get a Korean interpreter.
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These are tumultuous times for gun owners.
More than ever, the shooting industry is under attack, apparently assigned the burden of responsibility for the actions of evildoers hell-bent on slaughtering innocents. With every innocent drop of blood spilled, another finger is pointed at those whose tools were used to commit atrocities—a unique situation, given that knifemakers and breweries are never held accountable for the deaths involving their products.
As the 2013 Shooting, Hunting & Outdoor Trade (SHOT) Show got going today, gunmakers and outdoor media remain well aware of the issues faced by ordinary shooters across America, but it doesn't stop them from bringing new, innovative products to the table.
Last year, the public was introduced to such well-received new products as the Springfield XD-S—finally a compact, single-stack personal defense pistol, in .45 no less—and the Mossberg Flex system, which turned shotgun customization on its head with its Tool-less Locking System.
So what could possibly surprise us this year?
Well for starters, Winchester rolled out its revolutionary new rimfire cartridge, the .17 Winchester Super Magnum, offering range and speed like no other rimfire round before it.
New compact handguns like Ruger's brand new LC380 will also grab the public's eye, tools that will ultimately prove useful in personal defense situations, and without breaking the bank too. In the same vein, we see iconic models being offered in interesting new variations; Walther's legendary PPK, for example, will hit shelves in a rimfire offering, and Remington continues its into the 1911 market with its R1 Carry.
And what about long guns? Remington's Model 783 is already making rounds around web, and even in the midst of controversy, numerous ARs like the DPMS 6.8 Hunter and the Colt Competition M2012 are set to debut in Las Vegas, showing the platform's true usefulness in the world of shooting sports.
As we showcase—as well as gawk at—some of the new firearms, ammunition and accessories hitting the market, we understand that the federal government isn't exactly what one might call "gun friendly," and anything "outdoorsy" is far from being considered mainstream.
But that doesn't make our freedoms any less important. Shooting and hunting are American traditions, and when done in a safe, responsible manner, can provide lifetimes of enjoyment. They're freedoms guaranteed to us by the supreme law of the land, and groups like the National Shooting Sports Foundation—organizers of SHOT Show—will not allow any institution to compromise those rights.
That's why you should care about SHOT Show. As we bring you up-to-speed coverage throughout the next week—and as you begin picking out early birthday/Christmas presents—take time to consider exactly what the outdoor industry means to you, and take the time to appreciate the freedoms you enjoy.
Events like SHOT Show are a clear reminder that the outdoor industry is alive and well, and that outdoorsmen across the nation aren't about to just surrender their rights.
After all, hunting and shooting aren't just hobbies; they're a way of life.


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By Stephanie Ciccarelli
September 9, 2007
Did you know that you only have two more days to vote for your favorite Simpsons Sound Alikes?
Voting closes on Tuesday September 11th, so vote now to have your say.
Looking for voice talent? You've come to the right place. Post a job and you'll get sample recordings of your script and price quotes.
Vox Daily offers a daily dose of voice acting news, articles, tutorials, interviews, intelligent conversation and business ideas for voice talent and voice actors.
Our feed & social options update you with special offers and news as it happens.


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We need to talk.
Living abroad has many attractions, but it is not without its drawbacks.
Unfamiliar local bureaucracy and a foreign tax system can be very confusing, especially when the rules frequently change. To confuse matters, you may also still be liable to some UK taxes.
In today's economic climate, wealth preservation has become extremely
difficult to achieve without the help of good advice. There are a number of
major threats to the preservation of your wealth.
Our raison d'être is to provide a service to our clients which enables them to enjoy a tax-efficient income and preserve the value of their wealth, not only during their lifetime but also through to the next generation.
20 August 2014
UK Plans To Restrict Personal Tax Allowance For Non-Residents
The UK government is considering another tax reform which could affect British expatriates, depending on your circumstances. It is considering whether to withdraw the personal tax allowance from non-residents, unless they have a strong economic connection in the UK.
read more ...
13 August 2014
Beware The Spanish Taxman
Now that the first Modelo 720 (overseas assets reporting) forms have been submitted and processed, people have started hearing from the Spanish tax inspectors. The tax authorities have also recently announced an amnesty for undeclared foreign souce pension income.
08 August 2014
Already Living In France Or Thinking About Doing So? Some Essentials To Consider…
We run through the tax and financial essentials you need to be aware of and plan for if you are to get the best out of living in France.
Already Living in Spain or Thinking About Moving There? Some Essentials to Consider…
We run through some of the tax and financial essentials you need to be aware of and plan for if you are to get the best out of living in Spain.
01 August 2014
UK Pensions – "Freedom And Choice"
The biggest reforms to UK pensions in almost a century are underway. As more options become available, you need to understand how they affect you and consider what would work best for you in the short and long term.
25 July 2014
Portuguese Proposed Tax Reforms
The Portuguese government has released its proposed tax reforms. They are open to public consultation, after which it is presumed they will be incorporated into the 2015 budget.
Swiss Banks And The Tax Evasion Crackdown
On 6th May, Switzerland joined with other OECD members in committing to apply automatic exchange of information, effectively committing to end banking secrecy for tax purposes. There has also been other news about Swiss banks and tax evasion issues.
12 July 2014
When Is Your Tax Freedom Day?
If you ever had the feeling that you spent half your working life just to pay tax, you are probably not far wrong. If you are lucky enough to be retired you are still faced with tax on your savings, investments and pensions, not to mention VAT. Tax planning is an important part of protecting your wealth in retirement.
04 July 2014
Press Release - Maltese Prime Minister Keynote Speaker at Blevins Franks Conference
The Prime Minister of Malta, the Honourable Mr. Joseph Muscat, was the keynote speaker at the annual Blevins Franks Wealth Management Conference which this year was held in Malta in late June and was attended by 150 delegates from around Europe.


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Bonner's Ockimey shows versatility
- Written by Donald Hunt
- Published in Football
It's always good to have a multi-talented player. Bonner-Prendergast has a terrific one in Michael Ockimey, who can play on both sides of the football. Ockimey, a 6-foot-4, 190-pound junior, has been a standout at wide receiver and defensive back.
He has 11 receptions for 216 yards and three touchdown receptions. Defensively, he has three interceptions. He's been able to make a big difference as a two-way performer.
"I try to run perfect routes," Ockimey said. "I try to get open. I have a good quarterback, Jim Haley, who does a nice job of getting me the ball. On defense, I try to make as many plays as possible. I like playing wide receiver and defensive back. I'm working as much as I can to get better at both positions."
It's no surprise that Ockimey has been able to play some good football. He comes from a sports family. His dad, Michael Ockimey, was a great baseball and basketball player growing up in Darby. Michael's twin brother, Josh Ockimey, is an All-Catholic League baseball player at Neumann-Goretti. He plays first base for N-G.
"Josh is a really good baseball player,"his brother said. "We talk all the time. I've seen him play baseball. I'm really proud of him. We help each other. He gives me good advice."
Michael Ockimey started his football career playing for the Darby Township Eagles as a defensive linemen and offensive tackle. When he came to Bonner-Prendergast, the coaching staff moved him to wide receiver and defensive back.
Ockimey played a big role in Bonner-Prendergast's 42-7 win over Conwell-Egan last weekend. He had five tackles and one interception.
"I did most of my work on defense," he said. "I didn't catch any passes this game. But this was a good win for us."
Bonner-Prendergast (3-3 overall, 1-0 league) will visit Cardinal O'Hara (4-3 overall, 0-1 league) on Friday, Oct. 19 at 2 p.m.
"This is a big game for us," Ockimey said. "They're our big rivals in the Catholic League. We had a great win in our last game. If we can continue to play good football, we'll be fine."


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Despite destroying the #1 ESPN team, Birds only #6
This actually makes me happy, since as yet no one is overhyping the Eagles, who DVOA thinks is the class of the NFL clearly over everyone else. But the logic at ESPN is strange. We destroyed the #1 team with our backup QB. We destroyed the #11 team. Our only losses were to the #7, #17, and #18 teams, all without our starting QB for the entire game. Ah well. If logic ruled ESPN, where would Dick VItale work?