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October 2011
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Now on DriveLiveTV: The 2012 Ford Fusion Hybrid
Feedback Helps Steer the Ford Focus Electric Interface
Mustang Alley Thrills Woodward Dream Cruise Visitors
Not Buying It
Autumn is Irresistible in Texas
Fight Back Against Sinus Infections
Make Fall Clean-up Easy
Vehicle Profile: The 2012 Ford Explorer Limited
Vehicle Profile: The 2012 Ford Focus
Car Care: Cooling System Maintenance
Built Ford Tough® Sales Event
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Explore Best-In-Class fuel economy with the Ranger and experience the power and capability of the F-150 boasting 22 MPG Hwy coupled with 420-lb.ft of torque.
Click "Full Story" for details.
Now on DriveLiveTV: The 2012 Ford Fusion Hybrid
Poised once again to impress critics and consumers alike, the 2012 Ford Fusion Hybrid offers a tech-filled cabin and efficient yet high-performing hybrid powertrain that propels you up to 47 miles-per-hour in pure electric mode.
Vehicle Profile: The 2012 Ford Explorer Limited
The SUV icon puts the accent on refinement.
Word has it that Ford designers burned a gross of candles at both ends as they developed the all-new Ford Explorer for the 2011 model year. Their devotion to detail resulted in a revolutionary, wheels-up revision of the seven-seat sport utility that started it all, as well as North American Truck of the Year honors bestowed by a jury of veteran automotive journalists. For 2012, the Ford Explorer Limited builds on the reinvented icons award-winning blend of safety, power, versatility and unsurpassed fuel efficiency with a host of standard and available refinements rivaling those found in luxury SUV nameplates costing many thousands more.
Vehicle Profile: The 2012 Ford Focus
Best in class straight out of the blocks.
Sweat every last detail and give buyers more than they could possibly expect from a compact car; that was the design principle behind the all-new 2012 Ford Focus. The result is a model line that outdoes the competition at every turn, offering segment-pacing value and fuel efficiency along with segment-first features you simply wont find in other vehicles in this class.
Fight Back Against Sinus Infections
There are many ways to help prevent and treat sinusitis.
Sinus infections, also known as sinusitis, are a widespread problem that can interfere with day-to-day life. The National Institutes of Health (NIH) defines sinusitis as inflammation of the sinuses that occurs with a viral, bacterial or fungal infection. Sinusitis can be caused by a common cold, allergies or a problem with nasal structure. For many people, the symptoms of congestion, coughing and headaches are often unbearable. Fortunately, however, there are simple steps you can take to help alleviate a sinus infection or even avoid one altogether.
Autumn is Irresistible in Texas
The northern region boasts nonstop seasonal celebrations.
The sights, sounds and even tastes of autumn are experiences not to be missed in Northern Texas. Fall is well underway, and there are plenty of attractions and events for the whole family. Explore what the season has in store before winter arrives.
Car Care: Cooling System Maintenance
Make sure your cooling system is in tip-top shape.
For most drivers, a new car is their second biggest financial investment after a house, and they need it to run reliably for many years. The cooling system is one of the most important, yet often neglected regular maintenance items in any vehicle.
Feedback Helps Steer the Ford Focus Electric Interface
A driving simulator allows for rave reviews, as well as constructive criticism.
As Ford engineers put the finishing touches on the MyFord Touch interface for the all-new Focus Electric, theyve turned to consumers for feedback. The Ford Focus Electric Simulator takes users on an 11-mile trip through different types of terrain, allowing participants several opportunities to get familiar with the interfaces gauges, graphics and more. So far, the feedback has significantly helped Ford improve its innovative new technology.
Mustang Alley Thrills Woodward Dream Cruise Visitors
Ford knows how to draw a crowd with coupes, classics and more.
On August 20, auto enthusiasts from around the world were in Michigan to attend the 2011 Woodward Dream Cruise, the worlds largest one-day classic car event. Although the festivities stretched from suburban Detroit to Pontiac, the Ford display at the intersection of Woodward Avenue and 9 Mile Road in Ferndale proved to be one of the events major showstoppers.
Not Buying It
Unusual celebrity endorsements.
Celebrity endorsements are one of the most effective and memorable advertising tactics. Whether they bring a forgotten celebrity back into the spotlight or showcase one of our current favorites, there is no denying that when celebs talk, we listen. While a coveted beauty endorsement is the norm in Hollywood, some of these endorsements, to quote the famous Ray Charles Pepsi campaign, Make you go uh-huh.
Make Fall Clean-up Easy
Check out these great tools to help with yard work this season.
Although everyone enjoys watching the leaves change color during autumn, cleaning them up after they fall off the trees isnt always so widely enjoyed. Here are a few tools to help make your yard clean-up a cinch this year.
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'My Jihad' Bus Ads Debut In Chicago
A new ad campaign debuted this week in Chicago that's sure to turn some heads.
On Monday, 25 CTA buses began sporting ads from "My Jihad," a new educational campaign introduced by the Council on American-Islamic Relations' Chicago chapter (CAIR-Chicago).
Founded by Ahmed Rehab, CAIR-Chicago executive director, the campaign was conceived as a response to the anti-Islam ad campaign created by conservative blogger Pamela Geller, who ran a series of controversial "Defeat Jihad" ads on city buses last month.
The goal of the campaign, Rehab explained, is "reclaiming Jihad from the Muslim and anti-Muslim extremists who ironically, but not surprisingly, see eye to eye on Jihad," according to a CAIR statement.
The literal meaning of Jihad, according to the BBC, is "struggle or effort" — not simply a "holy war" waged on behalf of Islam. It is a central doctrine of the Islamic faith.
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The Jean Harris Case
Wounds, Bloodstains and Ricochets
At the police station after the shooting, the cops told Jean she could make a phone call and she called Leslie Jacobson, corporate attorney and husband of Marge, the friend who introduced Jean and Hy. He answered the phone groggy and in his pajamas but was instantly wide awake when Jean told him, in a voice thin with exhaustion and pain, "I think I killed Hy."
"Don't say another word," he ordered. He got his associates out of bed at the emergency and they brainstormed for the best criminal lawyer for Harris.
The man recommended was forty-nine-year-old Joel Aurnou, a short, balding, roly-poly sort given to cigars and good suits and known as a sharp, effective attorney.
Released on bail put up by her brother and surrounded by friends, a listless, shocked Harris told them she did not care about a defense. She just wanted to die. Herman Tarnower was dead; what did it matter what happened to her?
Aurnou found a way to restore her will to live by appealing to her sense of responsibility as a mother. Did she want David and Jimmy to be known as the sons of a murderess? For their sake, he told her, she had to clear her name. Jean decided she had to stay alive to prove she was innocent of the crime of intentional murder and save her adult children from that stigma.
The prosecuting attorney was thirty-four-year-old George Bolen, a tall, trim, boyishly handsome man with an earnest manner who was known to be quite ambitious. He often gave an impression of a rigidity and strain, a tension that led him to ask questions that were hopelessly obscure or mangled in meaning. There was, for example, this exchange in his cross-examination of Jean Harris.
BOLEN: Mrs. Harris, [would you tell us about] certain incidents that took place at Dr. Tarnower's home and particularly in the bedroom?"
HARRIS: Could you be more specific?
BOLEN: Did you have conversations with Dr. Tarnower?
HARRIS: Yes, whenever we talked we had conversation.
Earlier in the trial, when questioning the gun salesman who sold Harris the lethal weapon, Bolen released this grammatical monstrosity into the courtroom: "Back in October and November of '78, sir, to your knowledge, was there any in-house procedures promulgated by either yourself or someone immediately superior to you with respect to the procedures to be done with respect to acquainting any prospective purchaser of firearms, with the operation, maintenance and care and general safety of any handgun, be it a gun, or any type of weapon?"
Much of the trial consisted of technical testimony that was very hard for the jury to follow. After all, there was no question that she had killed Tarnower. The question for the jury to decide was one of intent. Had she deliberately murdered the man or had he died as the defense maintained, of a "tragic accident" that occurred when the two of them struggled over the gun?
One of the major prosecution witnesses who testified about the physical evidence was the Korean-born Dr. Louis Roh, Deputy Medical Examiner of Westchester County. A soft-spoken man, Dr. Roh declared that he believed Harris shot the doctor while he lay in bed. The wound in the hand was made by a bullet that went on to the poor man's shoulder, Dr. Roh said, since the two wounds could be lined up for this scenario.
Furthermore, Dr. Roh testified that the number and location of wounds sustained by Tarnower were inconsistent with a struggle between a man of his size and a woman of hers. On cross-examination, Aurnou was able to cast some doubt on Dr. Roh's testimony by showing that Roh had changed opinions more than once from that he had given in the autopsy report and that he had told the Grand Jury.
Chief amongst the major scientific witnesses for the defense was Professor Herbert MacDonnell. Tall, thin, and bearded, MacDonnell is a respected criminologist and he contradicted Roh's assertion that the same bullet that went through Tarnower's hand went into his chest. Rather, MacDonnell tracked the trajectory of a bullet that had penetrated the double glass door of Tarnower's bedroom, then ricocheted and went into a deck. He found a bloodstain on the glass door's frame and traced its trajectory as well. He concluded that the two trajectories intersected at the very point Harris recalled she and Tarnower were when he was shot in the hand. That bullet did not go into the wounded man's shoulder, MacDonnell testified, but through the glass door.
The prosecution and defense engaged in a fierce verbal fencing match over three tiny bits of tissue found in the dead man's chest. Dr. Roh testified that they were bits of skin from the palm of Tarnower's hand. Withering cross-examination by Aurnou led Roh to concede that he was not completely certain of that diagnosis and defense pathologist Dr. A. Bernard Ackerman testified "unequivocal[ly]" that they were not.


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Style Map
Daily Dispatches From The Global Scene
East L.A. gang girls. Menacing condors. Maori tribeswomen. Makeup artist James Kaliardos rattled off all of these things at Rodarte yesterday, where he was attempting to create "the dark side of beauty." With a charred black lip and a series of full-sleeve, half-sleeve, and neck tattoo designs courtesy of MAC senior artist Chantel Miller, his efforts were an overwhelming success. Starting with a minimal base, Kaliardos dabbed concealer under models' eyes and brushed a dark mauve shadow on their lids for contour. Keeping everything "simple and strong," he skipped the mascara and blush, and focused his energies on the lips, where he filled in the middle with strokes of MAC Lip Pencil in Beet and then used an angled brush dipped into MAC Pro Lipmix in black to line the rest of the mouth. Nail connoisseur Deborah Lippmann echoed Kaliardos' trip to the dark side with her new "Funky Chunky," a sheer, texturized black lacquer that goes on slightly more uniformly than Marquis Moon, the sequined silver shade she premiered at this show last season. As for the hair, Odile Gilbert explained her coifs in a single word: "Beautiful." The stylist treated the models' tresses with Aveda Pure Abundance Hair Potion to create a salt-water texture and then laid a piece of wool on top, spraying it with hairspray so that it adhered to the hair. Gilbert referenced Edward Curtis' evocative images of the American West and Native Americans as the basis of the look, although her inspiration really came from the unique way the Mulleavys work with knitwear and the wholly different vantage point from which they approach their designs—a universal appreciation that resonated backstage.


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Outlook 2011 - cannot see other calendar, and why you don't use Apple products
Outlook 2010 Calendar. Unable to add Notes
Jan 18, 2012 at 3:47 UTC | Microsoft Office
Need help adding notes, not Lotus Notes, to the calendar in Outlook 2010. Can anyone help me?
4 Replies
Jan 18, 2012 at 4:27 UTC
What is preventing you from typing notes in an event?
Jan 18, 2012 at 9:58 UTC
One of the executives noticed when they went to print out the days calendar that there is a section called notes in the lower right corner.
Problem is, we cannot figure out how to put notes there or view this notes section inside outlook.
Jan 19, 2012 at 8:29 UTC
Ah, ok. That section is for handwritten notes.
Since the Notes inside Outlook are not dated, they don't show up on the daily calendar, or monthly even.
Jan 19, 2012 at 9:11 UTC
Alright, thank you very much.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.
It's FREE. Always will be.


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Hot video – Nicki Minaj & Drake "Moment 4 Life"
OK Drizzy, I see you in that popped collar and all black everrthang! I had to watch the whole video before I could actually deem it "hot," so there you go. Nicki and her fairy godmother had me cracking up almost immediately, and the Drake just continued the LOLs with his presence. Actually, to be honest, I thought he was fine until the end of his verse when he made that weird face. Sorry, Drizzy, just because Nicki can get away with making weird faces doesn't mean you can. I appreciate that he cleaned up a little since he looked so grungy in the "What's My Name" video. Anyway, those were some nice visuals to go with probably my favorite track off "Pink Friday."
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I am also having the same problem. I can't afford a survey.
I have a small yard and my neighbor keeps mowing my side yard almost up to my house. Today I guess I mowed too far on his side in the back yard, so while I was gone he got back at me by making 2-3 trips across my front yard. Needless to say I had to finish mowing the yard when I got home. I could get him for trespassing but I didn't see him do it. He was mowing his yard though when I arrived home. Any suggestions??


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In the wake of last night, I wanted to share thoughts on leadership. Before I start, my reactions to last night's game are simple: the players did well for the most part. We have the talent to play with anybody. Our talent level is that of a playoff team. AVP did a tremendous job. If Edwards plays like this all season, we're fine and he's more than fine.
So why do we lose the big games? Sure, we had some nice comeback wins: against Houston in 2006, and in the first few games last season. But we can't seem to win the important games. Dallas in 2007. Tennessee in 2006. Cleveland and the Jets last year. We can't seem to close out big games. It's the same, year after year.
My theory is lack of leadership from the head coach. I'm not an anti-Jauron guy. I hope he does great this year. But I've seen enough of him standing idol during the decisive moments to believe that he's not the guy we need.
Leadership background. I'm a US Army officer, and my job is to lead reconnaissance and scout units into combat, which I've done. So my definition of leadership and expectations may differ from yours. However, football is an end-sum game, where wins and losses are all that matters. This is why, I believe, you see coaches that take a bit of a military-style leadership into their roles as coaches, and many are successful. This is basically the entire Parcells coaching tree, Cowher, Gruden, etc.
Military leadership is not what you see on, say, the basic training portion of Full Metal Jacket. Military leadership does not equate to screaming at people. I'm not much of a screamer, and have been fairly successful, some would say.
Military leadership is about the leader being accountable for the results. No excuses. Military leadership is about letting your subordinates lead and learn, but during training, not when lives are on the line. And military leaders identify the decisive point, and lead their organization at that critical time.
Decisive Point Tactics. There is a planning and operations description- we'll go with the operations version, since you can't plan a football game from start to finish like you can with a military operation. Operations, or the execution phase, decisive point tactics refers to the commander using instinct, experience, and education to identify the crucial moment on the battle field where the battle is going to be won or lost.
Think of it as a see-saw, or teeter-tauter. You start at one end, standing on the seat. That end is on the ground (eg: you're not winning). You walk towards the center. At the pivot point, the board evens out, and as you take the next step, the board starts to tip the other way. That's the decisive point, where you go from not winning to winning. Military commanders get paid, in part, to correctly identify when that is happening, and influencing everything they can to ensure victory.
It applies in a football sense. Fans do it all the time. It's the point of the game that we're all on the edge of our seats. Who wasn't as the Pats were kicking the on-sides kick? The head coach had to sense this too. That's when the influencing comes into play. Sure, Jauron can't catch the ball for McKelvin, and really can't do anything on the field. But you can influence it. Good military commanders can influence the battle without firing a shot personally.
Jauron tends to let things happen. He trusts the players and allows them to play, but he does this to a fault. After April finished his talk to the hands team, Jauron should have been in there, emphasizing key points that April talked about, and stressing the importance of the situation. You see Belichick, Cowher, etc. doing this all the time. It's not a rah-rah thing.
It's about willing your team to victory. A "if you get the ball, don't worry about gaining yards. Two hands on the ball and don't fumble" might have made a difference. Especially from a coach viewed as a leader, not the coach you like and want to try hard for.
You might not think so, but plenty of good Soldiers forget basic things under stress. A leader reminding them goes a long, long way. Trust me. You think the hands team was nervous last night? A leader calms them through leadership- talking to his team and getting their minds right.
No excuses leadership. That's what we're missing. You saw it last night. And every time we lose a close game.


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Two feuding Red Hook gangs recruited teens to provide them with revenue over the summer, according to police. The young crooks were allegedly behind most of the gunpoint muggings in Carroll Gardens this August and some have since been arrested, stated the police captain at a recent council meeting.
At the first monthly gathering at the since the summer recess, residents from Carroll Gardens and Cobble Hill were in unusually high attendance Tuesday night, expressing concerns to the police captain regarding reports of violent muggings. In response, the police captain revealed the details of various investigations that had taken place in recent months, connecting criminal activity not only across contiguous neighborhoods, but as far as Pennsylvania and Ohio.
"What happens in Red Hook affects what happens in Carroll Gardens and Cobble Hill and the surrounding areas," Captain Schiff told the room, explaining that over the summer the 76th Precinct identified two gangs that were vying for control of Red Hook. They are known as the Mad Dawgs and the Stone Cold Villains.
As a result of the war, there were a number of shootings in Red Hook. One individual in particular named Calvin Stallworth appeared to be at the root of the trouble. Stallworth had absconded from Pennsylvania parole in February and had made Red Hook his new headquarters. Stalworth allegedly has ties to The Mad Dawgs and had returned to take control. On July 7, , which involved three victims. Police learned that one of the victims belonged to the Stone Cold Villains.
Working with PSA 1, the narcotics units and the gangs division, police flooded Red Hook with officers and were able to subsequently supress a lot of crime in that area.
In fact, a tip came back to the 76th Precinct that there was so much heat on Red Hook, Stallworth had fled the jurisdiction. The Fugitive Apprehension Team later tracked him down to Ohio. He was extradited back to Pennsylvania to serve out rest of his sentence. After that is completed he will return to Brooklyn to be extradited for his alleged involvement in other crimes.
"In the meantime, we flooded that area to such a high degree, the gangs weren't able to make their regular illegal income," said Captain Schiff.
Gangmembers decided to recruit 14-, 15-, and 16-year-olds to make up the difference. , phone snatches and the like, police said.
"We noticed what was going on," said Schiff. "Three or four weeks ago we had a major problem with that, no doubt about it." In the last 28 days, there have been 7 robberies in Red Hook, 6 in Carroll Gardens and 2 in Cobble Hill.
But police were quickly able to make strides on pinpointing the assailants. After the 76th got their hands on a picture of an individual allegedly committing robberies around Van Brunt Street, police circulated the photo over e-mail, blasted it on Twitter, and plastered it throughout the neighborhood.
"We have an idea who it is but unfortunately a few victims weren't able to ID this person," he said. "However, we put pressure on the individual that we suspected and since then there hasn't been a robbery in Red Hook.
"We've also made a number of arrests over the past two months," said the captain. "One individual was robbing residents at knifepoint, another was his acomplice and another was working independently. One was a 14-year-old female, the two others were 16-year-old black males. They are responsible for at least two robberies on Hicks Street."
On August 15, two male blacks, ages 15 and 16 respectively, were also arrested for alleged robberies. As a result, in the last two weeks only two robberies have occurred in any of the surrounding neighborhoods: one in the Gowanus Projects and another that was a domestic incident; they appear to be unrelated to the previous streak.
"There is no doubt that the kids and teenagers are the ones causing problems in our neighborhood and seeking crimes of opportunity," said Schiff. "But we have flooded the areas, and in the last two weeks the number of robberies has dropped."
The police captain went on to say that other suspects are on the precinct's radar but he could not disclose further information as the investigations are ongoing.
Various residents asked why they haven't seen more police on foot patrol, given the nature of these violent crimes. The captain responded that the reason was twofold: For one, most of his men patrol in vehicles or wear plainclothes in order to blend in with their surroundings and observe criminal activity.
The other reason, he said, was simply that resources are limited.
"I encourage residents who have been victims of a crime to report it to the police so that we have it on file," said Jerry Armer, community council president. "The more accounts we have on record per year plays a part in determining how much money is budgeted per precinct and how many police can be employed."
Armer added that neighbors can petition their local politicians to designate more funds for their local precinct as well.
"Those are the people who can give you what you're asking for," he said.
Stay with Patch for updates.


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CALEDONIA, Minnesota (WXOW) - At least one community in Minnesota could celebrate on Sunday. For the third consecutive year, and fifth time in the last six years, Caledonia football returned from the Metrodome with some serious hardware.
On Sunday, the community welcomed home the triumphant Warriors at Caledonia Area High School, honoring the team that completed the MSHSL's first ever Class AA three-peat in football.
Caledonia was able to defeat Moose Lake/Willow River 25-22 in Friday's thrilling rematch of the 2011 title game thanks in part to a last second field goal by Levi Schmitz. It wasn't always an easy road, but the Warriors found a way.
"My heart is still, it's not racing as much as it was, but every time I talk about it with somebody, I still get the feelings, the nerves and everything," said Schmitz. "My blood starts pumping. Just seeing all these people here that have supported us throughout the season, it's just great."
"Fan support is awesome. We came back into town, and there were people everywhere. Everyone was cheering. We had a ton of people at the game. It was awesome," added senior Jeremy DeWall.
Quarterback Alex Varney said, "We have the best fans in the whole state. Without them, we wouldn't be at the top where we are. They get us so excited. They get so loud. It's just amazing what they do for us."
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Event Information
Grand Rapids, MN 55744
Call: 218-326-9607
Toll Free: 800-355-9740
Fax: 218-326-8219
Region: Northeast
Add to My Favorites
- The tournament entry fee is $600 per team, and the registration deadline is Friday, August 23. For more information or to register, visit classicbass.com or contact Tournament Director Rick Pelletier at: email@example.com, (952) 270-3864.
Competitive bass fans have an exciting new option in tournament fishing. The Classic Bass Invitational will be held August 29-30 on Pokegama Lake out of Grand Rapids, Minnesota.
The team-format event offers 100 percent payback in cash and prizes, and allows anglers to pick their fishing partners—doubling the fun while splitting expenses. Two-person teams will enjoy intense competition on the 6,700-acre Mississippi River impoundment's renowned bass fishery—as they try to amass the heaviest two-day total weight of largemouths and smallmouths.
Although the Classic Bass Invitational was just announced this spring, it has already drawn serious attention from notable names in the Minnesota bass scene, including Ron Lindner, patriarch of what is perhaps the state's most famous fishing family.
As a bonus, participants will gather at a private premier to watch firsthand as the totally redesigned Classic Bass website goes live, showcasing the popular site's new look, cutting-edge content and streamlined functionality.
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Also at this Location
Visit Grand Rapids
10 NW 5th St Ste 212
Grand Rapids, MN 55744
Call: 218-326-9607
Toll Free: 800-355-9740
Our famed hospitality, combined with quality venues and endless recreational opportunities, makes it easy to plan successful vacations, conferences, and group tours.
Located just three hours north of the Twin Cities on the Mississippi River, Grand Rapids serves as the southern gateway to the Chippewa National Forest and is the birthplace of the legendary Judy Garland. Grand Rapids offers a range of experiences from modern convenience to rustic splendor.
Summers in Grand Rapids are not only beautiful, but full of recreational choices. Enjoy golf, hiking, biking, swimming, or just enjoying the summer breeze on the shore of one of the 1,000 lakes.
Grand Rapids is the hunting headquarters for deer and grouse. For the hunting widows, Visit Grand Rapids hosts a "Girls Weekend" with craft sales and events geared to any non-hunting visits.
When the snow falls, it's time to grab your snowmobile and travel on the more than 1,000 miles of groomed trails accessible from almost every lodging property. Any level of cross-country skiing is available throughout the area.


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> Abstract
Research Grants Awarded
Inhibition Of Lysine Specific Demethylase 1 (Lsd1) As A Strategy For Re-Expression Of Epigenetically Silenced Genes In Breast Cancer
Grant Mechanism:
Investigator Initiated Research
Scientific Abstract:
RATIONALE The primary purpose of the studies detailed in this application is to develop a new series of novel agents and strategies that target aberrant epigenetic silencing of genes in breast cancer. Epigenetic silencing results from a combination of promoter DNA hypermethylation and modification of histone proteins that favor closed chromatin conformation thus inhibiting transcription. Aberrant epigenetic silencing of tumor suppressor genes is critically important in the initiation and progression of breast cancer. Histone modifications, including acetylation, phosphorylation, and methylation, result in a combination of histone marks collectively known as the histone code. These modifications act in concert with gene promoter CpG DNA methylation status to determine whether specific genes are transcriptionally active. Recently, several laboratories including our own, have investigated means by which aberrant epigenetically silenced genes may be reactivated for therapeutic or chemopreventive advantage. This approach is based on the fact that unlike gene mutations, epigenetic modifications are reversible and reversing these modifications has the potential to beneficially alter the breast cancer phenotype through differentiation and/or restoration of growth control. Histone modifications are now known to be a result of dynamic processes; a prime example is the balance of histone acetylation maintained by the activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Recently a similar dynamic process has been demonstrated for histone methylation. The first lysine demethylase discovered, lysine specific demethylase 1 (LSD1), targets mono- and dimethyl-lysine 4 histone 3 (H3K4me1 & H3K4me2) and works through a FAD-dependent oxidation reaction. Promoter region H3K4me2 is associated with transcriptionally active genes and thus is considered an activating mark. Demethylation of this mark by LSD1 may broadly repress gene expression and dysregulated LSD1 activity may play a role in the inactivation of specific tumor suppressor genes. Further, emerging data indicate its activity is associated with abnormal gene silencing and is thus a target for therapeutic manipulation to facilitate the re-expression of aberrantly silenced genes. The catalytic domain of the recently discovered LSD1 is closely related to the FAD-dependent spermine oxidase (SMO). Our laboratory first cloned and characterized SMO and aided in the discovery of LSD1. Based on our expertise in polyamine catabolism, we hypothesized that certain polyamine analogues would effectively inhibit LSD1 and thus have the potential of reactivating epigenetically silenced genes. We have discovered specific polyamine analogues are potent inhibitors of LSD1, leading to re-expression of aberrantly silenced genes important in tumorigenesis. Gene re-expression is subsequent to increased promoter chromatin activating marks (H3K4me1, H3K4me2, & H3K9-acetyl), decreased repressive chromatin marks, (H3K9me1 & H3K9me2), and in some genes, decreased promoter CpG methylation. HYPOTHESES TO BE TESTED Our general hypothesis is that our novel polyamine analogue inhibitors of LSD1, when used alone or in combination with other agents targeting epigenetic silencing, will more be efficacious in re-activating aberrantly silenced genes in breast cancer cells than current strategies and thus have the potential to improve treatment of breast cancer. RESEARCH AIMS are to: 1) determine the most efficacious analogue and treatment protocols in our in vitro human breast cancer cell models using lines representative of the major forms of breast cancer, with respect to gene re-expression, chromatin changes, and growth inhibition; 2) advance the most promising LSD1 inhibitors into our animal model of human breast cancer for in vivo evaluation of biological response and efficacy; 3) use microarray analysis to define the changes in gene expression profile of breast cancer cells treated with agents targeting epigenetic gene silencing with the goal of identifying new targets for therapy. The ultimate goal of the studies detailed in this application is to provide sufficient data to determine if clinical trials of this strategy are warranted. UNIQUE ADVANCES IN OUR KNOWLEDGE OF BREAST CANCER The basic understanding of epigenetic regulation of gene expression in normal and neoplastic breast cells is rapidly advancing and thus offers a unique opportunity to exploit breast tumor-specific defects in this regulatory pathway for therapeutic advantage. Our recent discovery of LSD1 as a rational target for intervention coupled with our identification of novel polyamine analogue inhibitors provide an entirely unique and exciting new avenue with substantial clinical potential. As epigenetic therapies are currently being testing clinically in breast cancer, the addition of LSD1 inhibitors to such regimens has considerable promise in improving treatment outcomes. Thus the results of the studies proposed here should provide a solid foundation for adding novel agents to the current clinical armamentarium in the fight against breast cancer.
Lay Abstract:
RATIONALE The transformation of normal breast epithelial cells into breast cancer cells requires a series of changes that result in the altered expression of proteins that prevent normal breast cells from undergoing uncontrolled division. The loss of normal expression of the growth regulating proteins can result from genetic changes, specifically gene mutations in the DNA sequence or loss of chromatin containing the growth regulatory genes. A second general mechanism by which growth regulatory gene expression can be lost is through epigenetic changes. Specifically, genes can be switched off or silenced by changes in how DNA is packaged on chromosomes through physical changes in chromatin proteins called histones as well as modifications of DNA that do not change the actual DNA sequence. These non-sequence changes in DNA, termed DNA methylation, normally function together with histone proteins to properly regulate gene expression. In breast cancer, these processes are dysregulated and this can lead to inappropriate silencing of important growth regulatory genes called tumor suppressor genes. Breast cancer can be the ultimate result of this faulty regulation of the expression of critical regulatory genes in previously normal breast tissue. STUDY HYPOTHESIS AND TESTING The intense interest in epigenetic changes leading to breast cancer is based on the fact that epigenetic changes, such as DNA methylation and changes in histone proteins, are potentially reversible unlike genetic changes such as mutations or loss of chromosomes. Therefore, it is possible through treatment to restore normal growth control by reversing epigenetic changes that result in abnormal gene silencing. In fact ongoing clinical trials with FDA-approved drugs that block DNA methylation (5-azacytidine) combined with drugs that block the changes in histone proteins (histone deacetylase inhibitors) that lead to gene silencing have demonstrated promising early results in a form of leukemia. Histone acetylation is an important histone modification that is generally correlated with the activity of a gene. Histone deacetylases (HDAC) are proteins that can modify histones, thereby contributing to the aberrant silencing of genes. This leads to the concept of using drugs to maintain the acetylation status of genes to prevent abnormal silencing characteristic of cancer. Another protein that is responsible for epigenetic silencing of genes is lysine specific demethylase 1 (LSD1). LSD1 functions by removing methyl groups from a specific lysine residue on a specific histone protein. The removal of this methyl group then contributes to the switch off of genes that are regulated by the histone that has been demethylated. If this demethylation occurs improperly, as is thought to occur in the transformation of a normal breast cell to a breast cancer cell, it can lead to silencing of growth regulatory genes, thus contributing to carcinogenesis. OUR HYPOTHESIS IS THAT TREATMENT OF BREAST CANCER CELLS WITH OUR UNIQUE AGENTS THAT ALTER CHROMATIN CAN BE USED TO REVERSE ABERRANT SILENCING OF GENESTO RESTORE NORMAL GENE FUNCTION. THESE AGENTS CAN THUS ULTIMATELY BE USED TO TREAT BREAST CANCER. We have very recently demonstrated that blocking LSD1 activity with our newly designed polyamine analogues results in the reactivation of epigenetically silenced genes whose inactivation is important in the genesis of cancer. Thus, we have demonstrated that LSD1 represents a rational target for the development of drugs that target its activity in cancer cells. The primary goal of the studies in this proposal is to determine if inhibition of LSD1 with our new compounds in breast cancer cells offers potential therapeutic advantages over existing therapies, including strategies targeting aberrant epigenetic gene silencing. We will test these new LSD1 inhibitors alone and in combination with other existing agents including inhibitors of DNA methylation and HDAC in our cell culture and animal models of human breast cancers. Thus, the studies detailed in this application have the overall goals of advancing a novel approach of targeting epigenetic changes in breast cancer that can be rapidly advanced into clinical testing. UNIQUE ADVANCES IN OUR KNOWLEDGE OF BREAST CANCER AND IMPORTANCE OF THIS RESEARCH TO PATIENTS WITH BREAST CANCER Understanding how epigenetic control of gene expression contributes to cancer has offered a unique opportunity to exploit cancer-specific defects in this regulatory pathway. This is particularly true in breast cancer as many genes important to normal breast tissue growth and development are under epigenetic control. We have discovered both an important new target for breast cancer drug development, LSD1, and a new series of agents, specific polyamine analogues, to attack this target. As epigenetic therapies are currently being clinically tested, the potential is great that this new strategy for reversing aberrant silencing of important genes will be rapidly translated into clinical trials. Thus the results of the studies proposed in this application have the potential to have considerable impact on the systemic treatment available to women with breast cancer. Finally our team of a molecular pharmacologist and physician-scientist is uniquely poised to take our new scientific discovery through the needed preclinical work with a goal of translation into patient testing in the near term.
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text:
In English
Radio Helsinki
You arrived here at 12:10 Helsinki time Tuesday 2.9.2014
Finland has still not been overtaken by the rock revolution - at least not in terms of public performance
Music for dancing cheek-to-cheek still alive and well in Helsinki
print this
: This is one of those once-in-a-while articles that come up to present the translator with a conundrum wrapped in a riddle. In this case the problem is one of how to render the quintessentially Finnish term
, which translates only into the German word "Schlager", which in turn has no really acceptable equivalent in English unless you spend several lines on explaining it. Though the German - and Finnish - etymology might lead one in the direction of "hit" music, it is rather different from that, and it is not even "Eurovision music" any longer, since the Eurovision Song Contest has changed out of all recognition in recent years. It might pay the reader to take a quick look at the Wikipedia entry for "Schlager" (
linked below
) before reading the article itself.
By Pirkko Kotirinta
Ollaan lähekkäin
(Let's Get Close), sings
Markku Aro
, launching into his hit tune from the 1970s, and the atmosphere among the foxtrot, tango, waltz, and jive crowd on the dance-floor at Hotel President becomes a tad more intimate.
The band Diesel accompanies him, as it has done hundreds of times before, over an 18-year collaboration with Aro.
It is a Wednesday evening
and there are around a hundred dancers out tripping the light fantastic.
This is pretty good for a midweek night in Helsinki, and even better when you look at the blizzard raging outside.
When Vanha Maestro, one of the capital's dance meccas, closed down a few years ago to make way for a nightclub, everyone was saying that an old-school dancing restaurant could no longer pay its way in downtown Helsinki.
Since then the flag has been held aloft single-handedly by Wanhan Tanssikellari, in the Old Student House close to the junction of Mannerheimintie and Aleksanterinkatu.
Now the venue at Hotel President has joined the fray, and both places seem to have enough fidgety feet to fill the floor.
"They've been forecasting
the death of Schlagers more than once or twice in my time in this business", says 58-year-old Aro in the backstage area before he goes on for his gig.
"But just as long as people want to dance close to one another, then the old Schlagers and dance-tunes will stay alive and kicking."
Aro is also sceptical about the magical watershed powers of the Outer Ring Road, seen by many urbanites as the demarcation line between "Boondocks-Suomi" (where old-time dance is still king) and "City-Finland" where it has been usurped. He says the dance-floor crowd is the same both sides of the fence.
Some things have changed
since Aro's big success years of the 1970s.
The audience at gigs for a start: "People today know how to dance better than they did. In the old days there was always a crowd out front just stooging around and staring."
Markku Aro has been crooning a good while. In November of this year he will mark up 40 years since the release of his first recording.
The CD he released in February to mark the event is his 20th studio album. Nevertheless the singer has just the one gold album in his cabinet, from 1977.
"That's true. The albums don't sell heavily
, however much we put into them", notes Aro.
His previous release from a couple of years back contained one hit number with the dancehall fraternity, but sales of the CD were only modest.
"It may be that the dance crowd don't buy records", he ponders. "Except perhaps for
Kari Tapio
Then again
, on the list of best-selling albums for 2007, Kari Tapio only squeaks in at No.19.
Artists like
, folkrocker
Lauri Tähkä
, and the stars of the latest
Pop Idols
series on TV rule the roost, alongside the arrangements of hymns by actor-singer
Samuli Edelmann
and the latest collection of tunes by
Eppu Normaali
, a long-running band that had its roots in punk but has long since morphed into a kind of Finnish version of Dire Straits.
And yet the best-selling albums
do not tell anything like the whole truth about what Finland listens to - or more particularly, what it dances to.
A glance at the list of the most-played tunes for 2006, as collected by Teosto (the performance rights organization acting on behalf of Finnish songwriters and composers), and based on nationwide radio and TV airplay and concert and dancehall use, will demonstrate without a shred of doubt that it is the dancing crowd who still boss things, and not the heavy metallers or hip-hoppers.
The oldest tune in the list dates from 1934, a good many more predate the arrival of rock, or even of rock'n'roll, and the only piece dating from the current decade is
Hard Rock Hallelujah
, which was played to death after the Eurovision Song Contest win. Most of the songs on the list are definitely not what you'd hear in the disco or a rock club.
And the same pattern
is reflected in Markku Aro's set-list for the evening, with one number composed by
Georg Malmsten
from 1940, some of his own old hits, and a couple of evergreens in the mix.
The more recent Schlagers don't really last the course. Entertainment floods out from every orifice these days; there is a surfeit of bland wallpaper music, and at least in Aro's view there are no composers writing today that are a match for the likes of
Toivo Kärki
But right now Aro is into
Keskiyön aikaan
, his cover of the
hit from 1976, "I'll Meet You at Midnight".
Aro thows himself into his old warhorse with gusto.
And also with a certain satisfaction that at midnight, his show in Hotel President is coming to an end.
In his business, he might just as easily be starting off his set at this hour.
Helsingin Sanomat / First published in print 29.3.2008
Schlager (Wikipedia)
Finnish schlager: fear of hell and hope of heaven (Finnish Music Information Centre)
PIRKKO KOTIRINTA / Helsingin Sanomat
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PROFILE: Alex Stubb is too smart to make trouble
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text:
CATEGORIES Movies*WARNING: Potential Spoilers!*
Before a meteor becomes a meteor, it's part of a comet or asteroid composed of rock and/or ice, sailing majestically through space. Once a hunk of matter breaks off that asteroid, it becomes a meteor, and once it hits the Earth's atmosphere, it starts to disintegrate into smaller bits; in other words, as it progresses, it falls apart. This, unfortunately, is an apt metaphor for Prometheus, which crumbles to pieces around the halfway mark, and is all but indistinguishable from its original self by film's end.
That's not to say there's absolutely nothing redeeming about the movie. In fact, it's a suspenseful, at times jaw-dropping film, but there are more questions than answers at its empty core. Directed by Alien mastermind Ridley Scott, it has all the hallmarks of a modern sci-fi film: creepy, mysterious extra-terrestrials, gung-ho scientists ready to make the next big discovery, a cheeky, stone-faced android, and a collection of some of the most intense visual effects since Inception.
It starts off earnestly enough, as a team of explorers helmed by Elizabeth Shaw (Noomi Rapace) and Charlie Holloway (Logan Marshall-Green) stumble upon an ancient set of cave drawings. From there, we fast-forward to the late 2000s in outer space as Shaw, Holloway and a collection of scientists, geologists and engineers are cryogenically frozen on a ship and sent to the planet where they believe the drawings -- and perhaps the first man, hence the name of the ship, Prometheus -- originated from. But they're not alone. On board is the stern matriarch of the project, Meredith Vickers (Charlize Theron), whose father is the president of the company funding the trip, and David, an android expertly played by Michael Fassbender.
The mood on the ship is foreboding and antiseptic, and it's obvious that Meredith and David have other agendas beyond the simple scientific mission. What the motives are, exactly, is pretty unclear, and we don't really get an answer. We are forced to settle with the fact that they just aren't team players, and we never get to the heart of their motivations.
Once they land on the planet, the entire crew ventures out to a massive hulk of rock, an alien construction on a dry plain. This is the pinnacle of suspense in this movie, and probably the best collection of scenes in the film's two hour runtime. The inside of the construction is impressive, effects-wise, and we get some nasty gore and true Alien-esque moments of heart-pounding terror. But then, once they all leave the cave, the movie starts to come apart.
It isn't the acting that hinders the movie -- Rapace hits the mark as the action-movie protagonist and Fassbender is spot-on as the android -- but rather the plot and the continuity. It feels like the writers hit a dead end and didn't know where to go (much like most of the characters in the movie). Echoes of the final episodes of Battlestar Galactica came to mind as each character in Prometheus starts to make weird, unexplained decisions, some of which completely deny logic. One person turns against another, but their motivations are never explained. Medical staples are applied on someone, and they manage to hold despite multiple traumas and extreme physical exertion. A ship flips upside-down, yet drinking glasses are still sitting upright on the ship's bar counter. Little missed details and unanswered questions mar the experience, and gives the film a feeling of slapdashery.
It's sort of cheap to compare a current movie to a predecessor, but in the face of the Alien franchise (which Prometheus makes several direct nods to), this movie is a hollow shell, fabricated to appease the summer movie-going masses. One thing it's been good for is conversation, which has been happening on the Internet and in movie theatres across the continent -- so it's not a total waste.
Too bad it turns to dust before we can take a really good look at it.


text:
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The "geek mind" is concerned with more than just the latest iPhone rumors, or which company will win the gaming console wars. I4U is concerned with more than just the latest photo shoot or other celebrity gossip.
The "geek mind" is concerned with life, in all its different forms and facets. The geek mind wants to know about societal and financial issues, both abroad and at home. If a Fortune 500 decides to raise their minimum wage, or any high priority news, the geek mind wants to know. The geek mind wants to know the top teams in the National Football League, or who's likely to win the NBA Finals this coming year. The geek mind wants to know who the hottest new models are, or whether the newest blockbuster movie is worth seeing. The geek mind wants to know. The geek mind wants—needs—knowledge.
Read more about The Geek Mind.
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We sell 100% authentic longchamp bags. Each package comes with: dust bag, tag, and care card. If you find a fake longchamp bag when you receive an order, we will give you a full refund, so you choose and purchase !
Founded in 1948 by Jean Cassegrain and aptly named after a local Paris horse track, Longchamp first gained fame by using the finest calfskin leather to sheath pipes, a stylish luxury at the time. Today, the Longchamp name is branded worldwide as a renowned bag designer and manufacturer.
Longchamp Is The "It" Bag
Longchamp is best known for its zippered nylon totes from its Le Pliage collection (see Longchamp Le Pliage Collection). Why is the Longchamp Le Pliage the "it" tote?
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Longchamp makes bags for real people. They are great for work, for shopping or on campus.
And, don't let the reputation of the Le Pliage collection as a must have distract you from Longchamps range of leather bags. They are simply beautiful and in keeping with a classic, understated fashion statement.


text:
Trailer for JACK REACHER Starring Tom Cruise
July 3rd, 2012 by Graham McMorrow
Here is the first trailer Christopher McQuarrie's (The Way of the Gun) Jack Reacher starring Tom Cruise. It's an adapted from the Lee Child novel, One Shot where Jack Reacher is an ex-military investigator who uses his experience to track down a sniper. The cast is top shelf with Cuise, Robert Duvall, Richard Jenkins, Rosamund Pike, and Werner Herzog as the villain (that's awesome).
The film is scheduled to open on December 21st, 2012.
Tags: Christopher McQuarrie, Jack Reacher, Lee Child, One Shot, tom cruise, trailer


text:
« Chris Brown Announces New Album Title
Trey Songz and Monica Wrap 'Passion, Pain & Pleasure' Tour in New York »
Ke$ha Wants to Be 'Gangster,' Says Producer
Ke$ha is going hard in da paint. The pop star is looking to add a tougher edge to her new music, calling upon Bangladesh for the re-release of her debut album Animal. "She says she wanna be gangster," the super-producer behind Lil Wayne's "A Milli" told Rap-Up TV. Ke$ha has also been working closely with Dr. Luke on the deluxe repackaging, due later this year.
In addition to spilling about the "Tik Tok" singer, Bangladesh took the mic to discuss his feature-heavy solo project and the recent call he received from a "Dancing with the Stars" contestant. "I just got a call from Brandy," he shared. "She wants me to do her album—hard stuff."Tweet
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Search for exciting venues and eventsFind a Venue
If you need advice or help finding venues or event suppliers, use our free helpline service.
Chalet 14, Verbier, Switzerland
The sexiest chalet in the Alps used to be a hotel, before getting a no-expense-spared makeover in 2010. Now available to book through Abercrombie & Kent Ski (tel: 0845 618 2215), it sleeps up to 26 guests in three suites and 10 bedrooms and comes with a 10m pool and private cinema. For advice on events in the Swiss Alps, contact the Switzerland Convention & Incentive Bureau (tel: 020 7845 7686, squaremeal.co.uk/scib).
St Anton, Austria
Designed firmly with corporate groups in mind, Artemis has six large en-suite rooms and a 12-seater cinema. It also comes with chauffeur-driven Mercedes-Benz 4x4s. Champagne receptions and gourmet meals can be enjoyed each night, along with a range of teambuilding activities. Innsbruck is just an hour's drive away. Book through Scott Dunn's corporate break team (tel: 020 8682 5050).
Gella, Pamporovo, Bulgaria
Not exactly a ski chalet but close enough to the Bulgarian ski resort of Pamporovo to deserve a mention. Half-hotel, half-villa, this luxurious boutique property opened earlier this year, sleeps up to 12 and makes an ideal directors' retreat. There's a 10m pool, meetings can be held in the library and there's a plethora of teambuilding activities on offer. Book direct (tel: 00359 888 566 872).
This article first appeared in Square Meal Venues & Events Autumn 2011.


text:
Mountain View, Calif. -- While technologies such as microsensor-based data collection will present new trends in data management, relational databases are likely to endure, said panelists at a Computer History Museum gathering here on Monday night.
Pioneers in relational database technology from companies such as Informix, Ingres, IBM, and Oracle gave their perspectives on future and historical trends in data management, including reflecting on the work of Ted Codd, considered the father of relational database technology.
Michael Stonebraker, a founder of Ingres and Illustra who also held executive positions at Informix, said he believed microsensors, which would be placed in various products and monitor commerce via geopositioning systems, could become a disruptive technology.
"You can imagine database systems will be the recipient of a billion streaming messages saying, 'Here I am and I go here,'" Stonebraker said.
Business process management also will become a trend, said Roger Sippl, founder of Informix. Web services currently present a veneer on top of business logic, but there will be a revolution coming on dealing with business processes, he said.
"I think there's going to be a simple, powerful model for doing that," Sippl said. "It'll have as big an impact as the relational database."
Another panelist, Pat Selinger, an IBM Fellow and vice president of data management architecture and technology at the company, noted that business analysis capabilities currently are being added to database systems, but concurred that business process management will be the next trend in database management.
But Chris Date, an associate of Codd and author of the book An Introduction to Database Systems, cautioned panelists not to count out relational technology.
"I would just like to interject a note of caution: Anybody that is starting to think about these new models must understand the relational model thoroughly. First, it may turn out that we already have the model that we need," Date said.
Relational databases can store immense quantities of data and keep historical records, he said, adding that the industry should make sure it really needs a new model for data management before inventing one.
"You can do things in the relational model. You do not need extensions to the relational model," Date said. "Business rules, I think, are totally compatible with the relational model."
Stonebraker also noted the importance of relational technology. "Ted Codd's contributions don't come along everyday. I don't see another thing coming at that level anytime soon," he said.
Stonebraker also had a word of caution for those who think Web services will become the dominant data integration technology.


text:
Save to My Recipes
Parmesan Chicken with Caesar Roasted Romaine
Published: March 2012 Servings: 4 prep: 10 minutes total: 20 minutes
- 4 7-ounce skinless, boneless chicken breasts
- Kosher salt, freshly ground pepper
- 1/2 cup grated Parmesan, Pecorino, or Asiago cheese (about 1 1/2 ounces)
- 1/2 cup panko (Japanese breadcrumbs)
- 3 tablespoons extra-virgin olive oil, divided
- 2 tablespoons chopped flat-leaf parsley
- 2 garlic cloves, chopped, divided
- 2 large hearts of romaine, halved lengthwise
- 4 anchovy fillets packed in oil, drained, chopped
- 1 lemon, cut into 8 wedges
Nutritional Information
1 serving contains:
- Calories (kcal) 360.8
- %Calories from Fat 41.9
- Fat (g) 16.8
- Saturated Fat (g) 4.3
- Cholesterol (mg) 121.4
- Carbohydrates (g) 5.9
- Dietary Fiber (g) 1.0
- Total Sugars (g) 0.8
- Net Carbs (g) 4.8
- Protein (g) 43.9
- Sodium (mg) 341.4
PREPARATIONView Step-by-Step Directions
Preheat oven to 450°. Line a large rimmed baking sheet with foil. Season chicken with salt and pepper; place on prepared sheet. Combine cheese, panko, 2 Tbsp. oil, parsley, and 1 garlic clove in a medium bowl; season with salt and pepper. Pat panko mixture onto breasts. Roast chicken until crumbs begin to turn golden, about 10 minutes.
Drizzle romaine with 1 Tbsp. oil and sprinkle with remaining 1 chopped garlic clove. Season with salt and pepper. Remove sheet from oven; place romaine around chicken. Roast until chicken is cooked through and lettuce is browned at edges, about 5 minutes. Divide among plates. Top lettuce with anchovies; garnish with lemon wedges for squeezing over.
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17Carrie Fisher Hopsitalized After Bizarre Performance
Carrie Fisher had a bizarre performance on a cruise ship after which she was hospitalized. TMZ has the exclusive video and I watched it expecting something horrifying, but it's really just cringeworthy. It's nothing like the bizarre meltdown Kanye just had during a live performance where at the end of his song he started screaming, over and over, and then violently threw his microphone on the floor, almost hitting the front row. THAT is something that I could believe would lead to a necessary hospitalization.
In the video, Ms. Fisher is cleaning up after her dog who just pooped onstage (and by cleaning up I mean she picks it up with a napkin and then throws it on a couch, saying, "Where else am I supposed to put it?") and then starts singing. I'm not sure what the context is here; if she was expected to sing or if she was there to do a reading, or what. There's no musical accompaniment. She's singing a cappella swaying and stumbling around, forgetting lyrics, and then asks the audience what song they'd like to hear.
But it was apparently weird enough for her publicist to release this statement,
There was a medical incident related to Carrie Fisher's bipolar disorder. She went to the hospital briefly to adjust her medication and is feeling much better now.
Okay, let me say something here. I realize that not everyone is the same when it comes to mental illness. There a varying degrees of how severe an illness is. There's a bipolar spectrum; some are on the high end, some on the low end. But saying that because someone did a weird, seemingly spontaneous singing performance on a boat and blaming it on being bipolar makes no f-cking sense to me. Honestly, I think she's just drunk. She's singing on a boat and it's a little embarrassing but she's not having a major episode like when Britney Spears shaved her head. It seems like now we're so quick to blame everything on mental illness, and I don't like it.
I am keeping in mind though that I know NOTHING about her condition or her treatment, and it is entirely possible that this has something to do with being bipolar and maybe needing meds adjusted but I still think it's bullshit. When you have a mental illness and you stop being happy for 2 seconds the first thing people ask is, "MAYBE YOU NEED YOUR MEDS ADJUSTED???" My theory is that she's drunk and that's not something her people want to admit, considering that she is a recovering alcoholic.
What do you think? (And by the way, I'd like to add that I know that Carrie Fisher is bipolar. I recommend her book Wishful Drinking to anyone. I know that she has a history of mental illness. I'm not saying that she isn't bipolar, I'm saying that I'm annoyed that we're using mental illness as a blanket excuse for any behavior that isn't deemed "normal.")
February 26, 2013 at 4:30 pm by Catherine St. Ives
17 Responses to "Carrie Fisher Hopsitalized After Bizarre Performance"
I hope she is well, she'll always be Princess Leia to me and I adore her.
You're spot on in pointing out the over-medication of the western world, but your comments on mental illness betrayed that you really do "know NOTHING about her condition". When people are struggling with certain mental illnesses, their behaviour might seem odd- that's all part of their insight, judgement and perception being impaired by said illness.
I do understand that this is a gossip website, and lord knows I love the Evil Beet snark on a daily basis (and I think you've done a great job since joining on!)
Stigma against mental illness is particularly damaging, since mental illness effects many of us within our lifetime and shaming in society at large makes it difficult for people open up about mental health struggles and seek help when it's needed. Many feel that "mental illness" is a damaging blanket term that obscures the wide spectrum of disorders, traits and episodes. Carrie's behaviour certainly could have been the result of drinking (*clutches pearls*), but if she struggles with Bi-Polar Disorder it could also easily be the result of a manic episode- or drinking while experiencing manic episode, which would certainly make a lot of sense.
"saying that because someone did a weird, seemingly spontaneous singing performance on a boat and blaming it on being bipolar makes no f-cking sense to me."
That's okay, but it does make sense to myself. People get manic, and sometimes when they get manic they get giddy and silly- and sometimes they get giddy and silly and drunk. Singing and swaying isn't cause for hospitalization, true, but impaired emotional regulation and judgement as a result of mania could be.
More information on Bi-Polar Disorder for anyone interested:
Anyway, thanks for listening and thanks for all your work on the blog- I really mean it when I enjoy it daily. You guys are the best part of my coffee break between meetings! (Except for coffee. Nothing beats coffee.)
I have to second Paisley here. I suffer from a mental illness myself…I can imagine how shocked most Evil Beeters are to hear this. Getting mental illness out of the shame game and officially recognized by the public at large as a disease (because the AMA already has) has been an uphill battle. Be thankful you don't suffer from one. On another note, maybe she was on a Carnival Cruise ship and just freaked the hell out. I know I would!!!!
Here is an interview with Carrie Fisher from a couple of years ago where she speaks frankly about living with bipolar disorder and her ongoing 30 year struggle with alcohol and drug addiction: http://www.bphope.com/item.aspx?id=630 . Fisher has never claimed continuous sobriety, although the 8-year stretch she achieved is considered long term. Many people living with untreated bipolar or who are in a manic episode with "medicate" with alcohol and drugs. I love the celeb gossip on this site, the photos, the rumors and even the snark. But posts like this–where a blogger makes light of a real, difficult situation or reveals gross ignorance by her comments–are totally off-base. Lainey over at LaineyGossip is about as bitchy, snarky and intrusive as they come, but she reigns it in and refuses to post anything that she deems "sad smut." You newer gals here might want to take a page from her book. You can be clever and reserve a little class, too.
"we're so quick to blame everything on mental illness, and I don't like it."
I did not find your comments insensitive or uneducated. I interpreted your comments to reflect on the "spinning" of every situation by publicists to gain empathy for their client. This lessens the publics awareness of mental illness instead of conveying the difficulties of it.
I loved your comments, Ms St Ives. Keep on keepin' on <3
Your comments were not in the least insensitive…you can't make everyone happy, and some people will always be offended, but I think it's pretty clear that you weren't making light of anything and your intentions and comments were from a good place. I personally am loving the new writers. it's very refreshing!


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The wait is over! Download the BeerAdvocate app on iTunes or Google Play now.
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Exp Hop 2012-6 - Bell's Brewery, Inc.
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Have one? Upload it now.
Ratings: 10 | Reviews: 4 | Display Reviews Only:
3.75/5 rDev -15.3%
04-04-2014 22:01:02 | More by Filabee
4.25/5 rDev -4.1%
01-12-2014 18:07:27 | More by jamvt
4/5 rDev -9.7%
11-27-2013 07:53:33 | More by ILikeGoodCider
North Carolina
4.25/5 rDev -4.1%
08-11-2013 13:09:00 | More by Shatter
4.5/5 rDev +1.6%
04-10-2013 18:47:14 | More by Zaphog
4.75/5 rDev +7.2%
02-02-2013 19:12:17 | More by mrebeka
4.66/5 rDev +5.2%
On tap at Bell's
A - Dark orange with a slight copper color. Opaque with a slight haze
S - Orange, mango, passion fruit and tangerine in a full and sweet nose. This beer smells amazing.
T - Strong bitter hop kick up front. Intermixed with sweet fruit flavors of mango, passion fruit and strawberry. There is a light floral flavor near the finish. Great and complex hoppy beer.
M - Thick syrupy beer that has light carbonation. Clean, fruity finish.
O - Solid fruity and sweet DIPA with only a slight kick of bitterness. This beer is so good because it is complex and has a lot of different hop flavors. It is full of bitterness, sweet fruit and light floral accents. I wish I could get some of this more often since I thought it was as good if not better than Hopslam.
The hops are definitely sweet and full of passion fruit and strawberry. 4.5
01-23-2013 04:08:03 | More by jeonseh
4.68/5 rDev +5.6%
What a beautiful color; one of the best looking IPA's I have ever seen. Off white head, with the most wonderful dank, deep fruity aromas that I can't much recall now, but dank weed mixed with ripe mangos and citrus comes to mind. The taste was so full bodied, with a fantastic backbone that IPA's are so often lacking. No lack of hops, but it wasn't a sour hop bomb, more of a fruity hop, but by no means overwhelmingly fruity. Overall, the standout IPA on a 5 day northern beer excursion in which I tried Dreadnaught, Artic Panzer Wolf, Anti-Hero, Crooked Tree, fresh Hopslam and others all on tap all at their respective breweries. Please bottle this, and I will buy it all.
01-16-2013 16:03:30 | More by Goosey
4.64/5 rDev +4.7%
Served on draft at Eccentric Cafe, 16 oz.
Pours a beautiful grapefruit ruby red, hazy, with a thin white head and great lacing.
Sweet citrus and malt aromas are present. Very bright and pleasant.
Taste is very similar to nose, sweet grapefruit and malt, crisp and refreshing.
Feel is smooth and relatively balanced without much bite on the end. Rather, it's very reminiscent of a grapefruit.
Overall, this is a great beer, and I'm really glad I had a chance to try it. Cheers.
01-06-2013 17:25:46 | More by rodlavers
4.8/5 rDev +8.4%
Reviewing the Exp Hop 2012-6 from Bell's Brewery, Inc. out of Kalamazoo, Michigan. This is an "experimental" double IPA that can only be found in Bell's Eccentric Cafe (their on-site tap room/bar).
Score: 98
Tap pour served in a taster glass at Bell's Brewery and enjoyed on 12/28/12. Review is from iPhone notes.
Appearance: Unfiltered tangerine color. Served with thin layer of white head. Crazy lacing and retention. The color and appearance scream fresh IPA. 5/5
Smell: Mango, pine, grapefruit and pineapple. Smells like hoppy tropical fruit juice. Hint of lemon 4.5/5
Taste: Super dank grapefruit, mango, and peach. Sweet tropical citrus. Malty "orange juice" backbone. Grassy piney hops add a good amount of bitterness to counterbalance the sweet citrus. Bold and balanced, this beer pushes the extremes of what an IPA can do while remaining easy drinking and non-palate wrecking. Easy drinking; absolutely no booziness whatsoever. I was absolutely stunned to discover this beer is over 10% ABV. 4.75/5
Mouthfeel: Perfect IPA mouthfeel. Medium bodied, medium-light carbonation. Oily on the tongue with a nice bitter perk from the hops. 5/5
Overall: Unexpected, delicious and bold in flavor. Bells needs to bottle this one; it's a knock out success. I would easily buy a case or multiple growlers if it was made available "to go." This is one of the best IPA I have had in a long time.
Recommendation: Hop heads should absolutely seek this beer out before it's a long-forgotten one off. If I was not the "designated driver," I would have ordered several pints of this brew.
Pairings: Asian zing BBQ chicken wings.
Cost: $5.75 for a snifter glass that looked slightly larger than 12 oz in size.
12-30-2012 02:06:53 | More by jegross2
Exp Hop 2012-6 from Bell's Brewery, Inc.
91 out of 100 based on 10 ratings.


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The Food Bank of Northern Nevada has declared September "Hunger Action Month" and are asking everyone to get involved and help spread awareness of the importance of helping feed the hungry in our community.
The Food Bank says they serve about 97,000 people each month and they're always in need of donations of food.
And there's another way you can help the Food Bank coming up this weekend.
De De Rosene is holding a garage sale as part of the third annual 'Run on Tuna' - an effort to raise thousands of tuna cans for the Food Bank.
It's Saturday from 7am until noon at 350 Sunnyside Drive just off Keystone Avenue.
If you can't make that and still want to donate, just go to www.fbnn.org
Mailing Address:
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By 2015 we will have production capacity of 1.5 million vehicles per annum.
The best way to find out all the Steed has to offer is to take it for a test drive. You're sure to discover why we are defying the motor industry downturn and continuing to develop at a rapid rate in China and across the world.
With 700,000 Steed vehicles already sold, you can join the many who are enjoying a vehicle with exceptional build quality, high specifications as standard, and some of the lowest running costs available in the UK pick-up market.
And, as part of the Great Wall Promise, if you live within 20 miles of any of our dealerships, we can arrange a test drive at your location. Or, if you'd prefer to drop in and meet your local dealer, you can count on a warm welcome.
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Our Mission
Teaching today's youth valuable life skills through the basic fundamentals of wrestling.
Our Vision
Aske'o International Mat club (AIM) will provide cutting edge wrestling techniques and relevant meaningful life skills. In addition, (AIM) will also work to develop healthy social behavior in each wrestler by teaching the difference between positive and negative leadership. In an effort to reach all people, we will strive to create a diverse and multicultural environment which speaks to the true meaning of team and breeds unity. (AIM) is targeting today's youth and preparing them to become tomorrow's leaders.
Practice Schedule
Monday thru Friday
Location: Evergreen High School (wrestling room).
Monday thru Friday
Location: Evergreen High School (wrestling room).


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Staples.ca: Canon MF4770N All-in-One Monochrome Laser Printer $80 (Was $200) + Free Shipping
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Evans Equipment, Inc. is a used equipment dealer in
Concordia, Missouri.
We welcome you to our website!
Evans Equipment deals in late model used and rebuilt mining and heavy construction equipment. Our specialty is in remanufactured Caterpillar equipment. Since 1965, Evans Equipment has processed thousands of machines; many have been completely remanufactured from the bare frame.
We are an established used equipment dealer with a long history of doing business in a professional manner. Go ahead and take a look at our rebuild process to get a look into how we provide better equipment quality to our customers.
Take a look at our Machine Inventory, browse our Rebuild Page, and give us a call!
Please note that every machine advertised is subject to prior sale.
|Listed below are some of the countries we've done business in over the years:


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Parafactor - American Bigfoot w/ Cliff Barackman
- Theparafactor
- uploaded: Mar 7, 2010
- Hits: 2580
We sit down to discuss the idea of existing bigfoot in the United States, what their population size might be like as well as how they have evaded capture this long. We also discuss the Gimlin-Paterson footage and look at the underlying musculature and gait of the walk of the beast in the footage.
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text: |Bronze Bust of Omar Nelson Bradley Sculptor: Nison A. Tregor He was born in Vilna, Lithuania in 1904 and served as a non-commissioned officer in the Russian Army from 1919 through 1920. In 1922, Tregor came to the United States and studied sculpture under Malvina Hoffman and Herman Atkins McNeil. He created busts of Dwight D. Eisenhower and also of General Douglas MacArthur, Governor Alfred E. Smith of New York, Henry Ford, Knute Rochne of Notre Dame and many others. In 1943 he volunteered for military service and received a direct commission as a 1st Lieutenant. He attained the grade of captain in the U.S. Army and was released from active duty in 1946. Tregor served initially in the Sanitation Corps as a medical photographer for the Army Medical Museum at Walter Reed Army Medical Center. His primary duty was as a sculptor and assistant to the plastic surgeon in determining the best method of reconstructing facial features disfigured as a result of war injuries.


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As business schools close out the admissions process for the 2013-2014 academic year, tallies of plagiarized applications are emerging. Some schools have begun to use Turnitin for Admissions — software to check originality in admissions essays — and they are finding that yes, a percentage of the application essays have been plagiarized. Bloomberg Businessweek has reported that UCLA's business school "rejected about 115" applicants in the last few years and Penn State's has rejected "about 87 since 2009."
While originality-checking software has long been used in classrooms, it's relatively new to the admissions process. Turnitin for Admissions, part of the larger Turnitin anti-plagiarism company, began in 2009.
The essay portion of a business school application is one part of the application overall; applicants also submit GPAs, resumes, recommendations, and standardized test scores. The essays help application committees to get a sense of who the applicant is. Turnitin for Admissions helps schools make sure that "people they are admitting are ethical and are who they say they are," according to Turnitin's Chris Harrick.
At heart, the software is a flagging system, a tool used to indicate which passages might be questionable. Someone at the university has to review the text and make the call if the similarities are actually plagiarism.
About 20 business schools have signed up with Turnitin for Admissions and only a few of those have publicly acknowledged using it. Dr. David Wangaard, executive director of the School for Ethical Education (the school is a sponsor of Turnitin's "Plagiarism Awareness Week"), argues that any school who uses such software should be transparent about its use. According to Wangaard, schools should tell applicants, "You're applying here, your application is going to be screened."
At the same time, Harrick points out, some schools don't want to talk about using Turnitin for Admissions because the schools don't want to be seen as endorsing a given product. And then there's this: In terms of selective schools, says Harrick, "a lot don't necessarily want to admit that they have a problem."
Cheating can happen anywhere, and when the stakes are high, cheating may be more likely. A recent New York magazine article explored the problem of cheating at the prestigious Stuyvesant High School in New York City. According to the article, recent research found that even the most impulsive cheaters cheated less often when they believed the point of the test was to help them master the material, not just get a score. "If everything is always high-stakes," [Professor Eric] Anderman says, "you're going to create an environment conducive to cheating."
In 2012, newly-graduated students from 2-year full-time MBA programs who got job offers reported that they received an average of an 81% base salary increase over what they had earned before getting their MBAs (Graduate Management Admission Council – Global Management Education Graduate Survey). An 81 percent salary increase could be seen as a high-stakes situation. Anderman was talking about high school students, but extrapolating from what Anderman says, a significant salary increase could mean that businesss school applications are very high-stakes, and therefore create an environment conducive to cheating.
Rutgers professor Donald McCabe has researched and written extensively about academic honesty. He points to the importance of schools' creating a culture of honesty as a way to prevent plagiarism overall. "Communicating to students that the institution cares about the issue seems to be an important first step," he writes in the International Journal for Educational Integrity. He argues that the "constant flow" of reports of cheating in many professions "can create the belief that everyone cheats to get ahead and if you want to be competitive and thrive in today's world, you'll have to do the same." Schools, he writes, may be the "our last chance to deliver a different message to young adults."


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NRSC Endorses IBiquity's FM IBOC
Columbia, MD and Warren, NJ - Nov 29, 2001 - IBiquity Digital Corporation, the sole developer and licenser of digital AM and FM radio broadcast technology in the United States, announced that the National Radio Systems Committee (NRSC) today completed its evaluation of iBiquity's IBOC (In-Band, On-Channel) FM technology and recommended that the FCC authorize the technology as an enhancement to the current analog FM broadcasting system in the US. The committee, which is jointly sponsored by the National Association of Broadcasters (NAB) and the Consumer Electronics Association (CEA), wrote that the FCC by approving the system would be "charting the course for an efficient transition to digital broadcasting with minimal impact on existing analog FM operation and no new spectrum requirements."
The NRSC's recommendation to the FCC is the result of a comprehensive test program devised and executed by the committee to determine the viability of iBiquity's FM IBOC technology and its ability to smoothly transition today's analog radio to digital. The test program included field tests of the system conducted at eight different FM radio stations across the country, in addition to laboratory tests and subjective sound quality evaluations by 480 listeners who evaluated thousands of audio samples recorded during the field tests. Specifically, in its report, the NRSC stated that the iBiquity FM IBOC (In-Band, On-Channel) system provides "greatly reduced impact of multipath interference (for mobile, portable and fixed receivers alike); superior resistance to co-channel and adjacent channel interference; support for enhanced data services; improved audio quality." IBiquity plans to rollout its technology in the U.S. next year with the launch of IBOC transmission equipment at the National Association of Broadcasters Conference in April 2002.
Milford Smith, the NRSC DAB subcommittee Chairperson, applauded the efforts of his fellow subcommittee members and those involved in the testing efforts. "The testing and evaluation of the FM IBOC system was extremely thorough. We reviewed data to determine the improvement in audio quality and reception, as well as the impact on today's analog FM and our evaluation confirmed the viability of the technology. IBiquity's FM IBOC technology has many advantages for broadcasters, manufacturers and consumers alike, and the transition will require relatively little inconvenience or expense. Radio will not remain the only analog medium in a digital world, and this system offers today's FM radio an excellent opportunity to smoothly transition to digital."
The complete report is available at the NAB's Science and Technology website at This link (http://www.nab.org/SciTech/Fmevaluationreport.asp).
About the NRSC
The NRSC is jointly sponsored by the National Association of Broadcasters and the Consumer Electronics Association. Its purpose is to study and make recommendations for technical standards that relate to radio broadcasting and the reception of radio broadcast signals. The NRSC is a vehicle by which broadcasters and receiver manufacturers can work together towards solutions to common problems in radio broadcast systems. The DAB subcommittee, which was established to evaluate the IBOC DAB technology, includes participants from over 50 companies involved in the radio broadcasting and consumer electronics industries.
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Soldier awarded the Military Cross for Bravery
A soldier who risked his life to save his comrades in Afghanistan has been awarded the Military Cross for his bravery.Corporal Keith Mitchell, of The Royal Scots Dragoon Guards, stood in open ground to draw enemy fire away from his comrades in an attack in Pulpalzay, Helmand, in March last year.
The 29-year-old abandoned the safety of cover behind a wall and stood up in open ground, so the enemy began firing at him instead.
With rounds raining down on him, he fired three accurate rifle grenades to suppress the enemy position, managing to either destroy or damage their capabilities. Firing ceased immediately allowing the wounded men to be evacuated.


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Home > Post > Post 11 > Post 11 News Release > 2007 News Releases > News Release
News Release
TPR Lloyd Cochran
Public Affairs Officer
Kentucky State Police
Post 11, London
(606) 878-6622
Click here to e-mail TPR Lloyd Cochran
Bank Robbery at the Monticello Bank Branch Office in Wayne County
Date of News Release: 12/12/2007
(London, KY) - On Wednesday December 12, 2007 at approximately 11:05 AM the Kentucky State Police Post 11 London received a report, from the Monticello Police Department, of a Bank Robbery at the Monticello Bank Branch Office in the Tradeway Shopping Center, Monticello, KY. Upon arrival Detective Doug Boyd discovered that a white male entered the bank and demanded money before fleeing on foot. Further details will be forthcoming as the investigation progresses. Detective Boyd is in charge of the investigation. Anyone with any information on this incident is urged to call the Kentucky State Police at (606) 878-6622 or 1-800-222-5555 (in the state of Kentucky only, does not work out of state).