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Janagari Yesumani (From Surrey Comet)
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Book an announcement for publication online and in the next edition of the Your Local Guardian
Janagari Yesumani
Published in the Your Local Guardian on 29 June 12
I, Mrs Yesumani Janagari Daughter of Bhooma Reddy Janagari whose permanent address in India is: 12-10-590/10/5, Road #5, Indira Nagar, Warasiguda, Secunderabad 500061 and presently residing at : 101 Travellers Way, Hounslow, TW4 7QB. Hereby give notice of my intention to change my name to : Mani Janagari
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text:
Research Topics
Genomes and Genes
Summary: Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications267 found, 100 shown here
- Porosity of 3D biomaterial scaffolds and osteogenesisVassilis Karageorgiou
Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Biomaterials 26:5474-91. 2005b>Porosity and pore size of biomaterial scaffolds play a critical role in bone formation in vitro and in vivo...
- The use of bone-graft substitutes in large bone defects: any specific needs?G M Calori
COR, Orthopaedic Institute, G Pini, University of Milan, Italy
Injury 42:S56-63. 2011..The purpose of this study was to evaluate the type of materials used and their efficacy for the treatment of large bone defects in traumatology and orthopaedic surgery...
- Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteinsIgor I Slowing
Department of Chemistry, U S DOE Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
J Am Chem Soc 129:8845-9. 2007....
- Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineeringK Rezwan
Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
Biomaterials 27:3413-31. 2006....
- Cell colonization in degradable 3D porous matricesBenjamin J Lawrence
School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
Cell Adh Migr 2:9-16. 2008..Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions ..
- Porous scaffold design for tissue engineeringScott J Hollister
Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
Nat Mater 4:518-24. 2005....
- Fabrication methods of porous metals for use in orthopaedic applicationsGarrett Ryan
National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
Biomaterials 27:2651-70. 2006..Another potentially valuable property of porous materials is their low elastic modulus. Depending on the porosity, moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the ..
- Ultrahigh porosity in metal-organic frameworksHiroyasu Furukawa
Center for Reticular Chemistry at the California NanoSystems Institute, and Department of Chemistry and Biochemistry, University of California Los Angeles UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
Science 329:424-8. 2010..The volume-specific internal surface area of MOF-210 (2060 square meters per cubic centimeter) is equivalent to the outer surface of nanoparticles (3-nanometer cubes) and near the ultimate adsorption limit for solid materials...
- Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional studyRoger M D Zebaze
Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
Lancet 375:1729-36. 2010..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton...
- Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugsJie Lu
Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
Small 3:1341-6. 2007
- Ordered porous materials for emerging applicationsMark E Davis
Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Nature 417:813-21. 2002..In fact, porous materials now seem set to contribute to developments in areas ranging from microelectronics to medical diagnosis...
- Mesoporous silica as a membrane for ultra-thin implantable direct glucose fuel cellsTushar Sharma
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
Lab Chip 11:2460-5. 2011..We demonstrate that a mesoporous silica thin film (270 nm) is capable of replacing the conventional polymer based membranes with an improvement in the power generated over conventional direct glucose fuel cells...
- Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancerVeronika Mamaeva
Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
Mol Ther 19:1538-46. 2011..The data highlights MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application, and as interesting constituents in the quest for more refined Notch therapies...
- Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetesHyunuk Kim
College of Pharmacy, Pusan National University, Jangjun dong, Geumjeong Gu, Busan 609 735, Republic of Korea
Biomaterials 32:1685-93. 2011..We consider that this new prototype of porous PLGA MS has considerable pharmaceutical potential as a type 2 anti-diabetic inhalation treatment...
- Mesoporous silica nanoparticles for intracellular controlled drug deliveryJuan L Vivero-Escoto
Department of Chemistry and U S Department of Energy, Ames Laboratory, Iowa State University, Ames, IA 50011 3111, USA
Small 6:1952-67. 2010..Finally, the latest breakthroughs for intracellular controlled drug release using stimuli-responsive mesoporous-silica-based systems are described...
- Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffoldJie Wei
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, PR China
Biomaterials 30:1080-8. 2009..Such improved properties of m-WPC should be helpful for developing new biomaterials and may have potential use in hard tissue repair...
- Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic poresShuo Qian
Department of Physics and Astronomy, Rice University, Houston, TX 77251, USA
Proc Natl Acad Sci U S A 105:17379-83. 2008..Evidence suggests that the formation of such lipidic pores is a major mechanism for alpha-pore-forming proteins, including apoptosis-regulator Bax...
- Strength, fracture toughness and microstructure of a selection of all-ceramic materials. Part II. Zirconia-based dental ceramicsMassimiliano Guazzato
Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, 2 Chalmers Street, Surry Hills, NSW, Australia 2010
Dent Mater 20:449-56. 2004..In the present study, DC Zirkon, an experimental yttria partially stabilized zirconia, In-Ceram Zirconia slip and In-Ceram Zirconia dry-pressed were compared...
- Improvement of porous beta-TCP scaffolds with rhBMP-2 chitosan carrier film for bone tissue applicationAnder Abarrategi
Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain
Tissue Eng Part A 14:1305-19. 2008..Initial beta-TCP disks with an average diameter of 5.78 mm, 2.9 mm thickness, and 53% porosity were coated with a chitosan film...
- Structure and properties of bilayer chitosan-gelatin scaffoldsJin Shu Mao
Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China
Biomaterials 24:1067-74. 2003..These results suggested that the porosity and pore size of the scaffolds could be modulated with thermodynamic and kinetic parameters of ice formation...
- Mesoporous materials for drug deliveryMaría Vallet-Regí
Departamento de Quimica Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Angew Chem Int Ed Engl 46:7548-58. 2007..This Minireview deals with the advances in this field by the control of the textural parameters, surface functionalization, and the synthesis of sophisticated stimuli-response systems...
- Low stiffness porous Ti structures for load-bearing implantsB Vamsi Krishna
W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
Acta Biomater 3:997-1006. 2007..to reduce effective stiffness for load-bearing implants. Young's modulus and 0.2% proof strength of these porous Ti samples having 35-42vol.% porosity are found to be similar to those of human cortical bone.
- Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizesTony G van Tienen
Orthopaedic Research Laboratory, Department of Orthopaedics, University Medical Center Nijmegen, The Netherlands
Biomaterials 23:1731-8. 2002..Ingrowth of fibrovascular tissue and thus healing capacity depended on porosity, pore sizes and compression modulus of the implant...
- The in-vitro bioactivity of mesoporous bioactive glassesXiaoxia Yan
Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China
Biomaterials 27:3396-403. 2006..According to our results, MBGs calcined at 973K may possess the best in vitro bioactivity. The influences of the composition and calcination temperature upon bioactivity are explained in terms of the unique structures of MBGs...
- Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisationV Maquet
Centre for Education and Research on Macromolecules, University of Liege, Belgium
Biomaterials 25:4185-94. 2004..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
- Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriersIgor I Slowing
Department of Chemistry and US Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
Adv Drug Deliv Rev 60:1278-88. 2008..We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents...
- Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartanYanzhuo Zhang
Department of Pharmaceutics, Shenyang Pharmaceutical University P O Box 32, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, PR China
J Control Release 145:257-63. 2010..We believe that the present study will help in the design of oral drug delivery systems for the dissolution enhancement and/or sustained release of poorly water-soluble drugs...
- Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibilityHockin H K Xu
Paffenbarger Research Center, American Dental Association Foundation, USA
Biomaterials 26:1337-48. 2005..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
- Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam meltingPeter Heinl
University of Erlangen Nuremberg, Department of Materials Science Institute of Science and Technology of Metals, Martensstrasse 5, 91058 Erlangen, Germany
Acta Biomater 4:1536-44. 2008..microCT) analysis demonstrated the capability to fabricate three-dimensional structures with an interconnected porosity and pore sizes suitable for tissue ingrowth and vascularization...
- Biosensing using porous silicon double-layer interferometers: reflective interferometric Fourier transform spectroscopyClaudia Pacholski
Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gillman Drive, La Jolla, California 92093 0358, USA
J Am Chem Soc 127:11636-45. 2005..Detection can be accomplished either by computing the weighted difference in the frequencies of two peaks or by computing the ratio of the intensities of two peaks in the FFT spectrum...
- Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activityYu Shen Lin
Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
J Am Chem Soc 132:4834-42. 2010....
- In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristicsTian Yu
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
J Control Release 163:46-54. 2012..In all, surface characteristics and porosity played important roles in influencing SiO(2) biodistribution and pharmacokinetics...
- Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactorManuela E Gomes
3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, Braga, Portugal
Tissue Eng 12:801-9. 2006This study investigates the influence of the porosity of fiber mesh scaffolds obtained from a blend of starch and poly(epsilon-caprolactone) on the proliferation and osteogenic differentiation of marrow stromal cells cultured under static ..
- Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applicationsEnnio Tasciotti
Nat Nanotechnol 3:151-7. 2008..The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion...
- In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticlesXia Cao
Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People s Republic of China
Int J Nanomedicine 7:753-62. 2012..The purpose of this study was to develop a sustained drug-release model for water-soluble drugs using silica nanoparticles...
- Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffoldsDevang Odedra
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
Acta Biomater 7:3027-35. 2011..Thus we concluded that the VEGF-165 gradient promoted the migration, but not proliferation, of cells into the scaffold. These gradient scaffolds provide the foundation for future in vivo tissue engineering studies...
- In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulationBao Chen
School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
Int J Nanomedicine 7:199-209. 2012..With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation...
- Sulfonate-grafted porous polymer networks for preferential CO2 adsorption at low pressureWeigang Lu
Department of Chemistry, Texas A and M University, College Station, Texas 77842, United States
J Am Chem Soc 133:18126-9. 2011..Since these PPNs also possess ultrahigh physicochemical stability, practical applications in postcombustion capture of CO(2) lie well within the realm of possibility...
- Small calibre polyhedral oligomeric silsesquioxane nanocomposite cardiovascular grafts: influence of porosity on the structure, haemocompatibility and mechanical propertiesMaqsood Ahmed
Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK
Acta Biomater 7:3857-67. 2011..An important feature in determining the success of a graft is the wall structure, which includes porosity, pore size and pore interconnectivity, as these play a crucial role in determining the long-term patency of a ..
- Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fracturesJanina M Patsch
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
J Bone Miner Res 28:313-24. 2013..HR-pQCT images volumetric bone mineral density and cortical and trabecular structure measures, including cortical porosity, were calculated. Bone strength was estimated using micro-finite element analysis (µFEA)...
- The biocompatibility of mesoporous silicatesSarah P Hudson
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Biomaterials 29:4045-55. 2008..Although local tissue reaction to mesoporous silicates was benign, they caused severe systemic toxicity. This toxicity might be mitigated by modification of the materials...
- Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BBGuobao Wei
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2209, USA
J Control Release 112:103-10. 2006..The successful generation of 3-D nano-fibrous scaffold incorporating controlled-release factors indicates significant potential for more complex tissue regeneration...
- Effect of beta-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humansChristine Knabe
Department of Experimental Dentistry, Campus Benjamin Franklin, Charite University Medical Center Berlin, Abmannshauser Strasse 4 6, D 14197 Berlin, Germany
Biomaterials 29:2249-58. 2008..study examines the effect of two beta-tricalcium phosphate (TCP) particulate bone grafting materials with varying porosity on bone formation and on osteogenic marker expression 6 months after sinus floor augmentation...
- Synthesis and characterization of pore size-tunable magnetic mesoporous silica nanoparticlesJixi Zhang
Nano Biomedical Research Center, Med X Research Institute, Shanghai Jiao Tong University, Shanghai, China
J Colloid Interface Sci 361:16-24. 2011..44-1.54 cm(3)/g). We also demonstrate their high potential in conventional DNA loading. Maximum loading capacity of salmon sperm DNA (375 mg/g) was obtained by the use of the M-MSN sample with the largest pore size of 6.1 nm...
- Chitosan composites for bone tissue engineering--an overviewJayachandran Venkatesan
Department of Chemistry, Pukyong National University, Busan 608 737, Korea
Mar Drugs 8:2252-66. 2010..Herein, the preparation, mechanical properties, chemical interactions and in vitro activity of chitosan composites for bone tissue engineering will be discussed...
- Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibiaAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
J Bone Miner Res 25:983-93. 2010..The goal of this study was to characterize intracortical porosity in a cross-sectional patient cohort using novel quantitative computational methods applied to high-resolution ..
- Use of ordered mesoporous silica to enhance the oral bioavailability of ezetimibe in dogsFilip Kiekens
Formac Pharmaceuticals, Leuven, Belgium
J Pharm Sci 101:1136-44. 2012..In vivo evaluation in dogs confirmed the improvement of ezetimibe absorption with the use of OMS as drug delivery technology...
- Synthesis of double mesoporous core-shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis propertiesAhmed Mohamed El-Toni
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
J Colloid Interface Sci 378:83-92. 2012..The spherical size and porosity of the silica cores of DMCSS together with shell thickness can be tuned by controlling Stöber parameters, ..
- The packaging of siRNA within the mesoporous structure of silica nanoparticlesXu Li
Nano Biomedical Research Center, School of Biomedical Engineering and Med X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China
Biomaterials 32:9546-56. 2011..In summary, our siRNA packaging strategy extends the application potential of M-MSNs and the resulting siRNA delivery vehicles can be further tested for in vivo experiments...
- Development of porous chitosan-gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applicationsC Isikli
Department of Biomedical Engineering, Middle East Technical University, Ankara, Turkey
J Tissue Eng Regen Med 6:135-43. 2012..It was shown that the scaffolds prepared from chitosan, gelatin and HA are appropriate cell carriers for bone tissue engineering, especially those with sHA incorporated...
- Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methodsTarja Limnell
Division of Pharmaceutical Technology, Faculty of Pharmacy, FIN 00014 University of Helsinki, Helsinki, Finland
J Pharm Sci 100:3294-306. 2011..The fast release was also maintained after tableting. Loading of IMC into the Syloid particles alone was sufficient to produce similar IMC release profiles, as in the case of MCM-41 with the excipients...
- In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylationQianjun He
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding Xi Road, Shanghai 200050, P R China
Small 7:271-80. 2011..Neither MSNs nor PEGylated MSNs cause tissue toxicity after 1 month in vivo...
- Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imagingPatricia Horcajada
Institut Lavoisier CNRS 8180 Institut universitaire de France, Universite de Versailles, 78035 Versailles Cedex, France
Nat Mater 9:172-8. 2010..In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments...
- Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineeringPaola Fabbri
Department of Materials and Environmental Engineering, University of Modena and Reggio Emilia, Modena, Italy
J Mater Sci Mater Med 21:343-51. 2010..Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as ..
- Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM)Jayanthi Parthasarathy
School of Industrial Engineering, University of Oklahoma, Norman, OK 73019, USA
J Mech Behav Biomed Mater 3:249-59. 2010..the processing of titanium has led to a one step fabrication of porous custom titanium implants with controlled porosity to meet the requirements of the anatomy and functions at the region of implantation...
- Bone ingrowth in porous titanium implants produced by 3D fiber depositionJia Ping Li
Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, The Netherlands
Biomaterials 28:2810-20. 2007..deposition is a technique that allows the development of metallic scaffolds with accurately controlled pore size, porosity and interconnecting pore size, which in turn permits a more precise investigation of the effect of structural ..
- Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormoneHong Kee Kim
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Republic of Korea
J Control Release 112:167-74. 2006..The resultant pore-closed microspheres exhibited high protein loading amount as well as sustained rhGH release profiles. Also, the released rhGH exhibited structural integrity after the treatment...
- Effect of activated carbons modification on porosity, surface structure and phenol adsorptionG G Stavropoulos
Chemical Engineering Department, Aristotle University of Thessaloniki, TEI campus, P O Box 1520, 54006 Thessaloniki, Greece
J Hazard Mater 151:414-21. 2008..The beneficial role of nitrogen on phenol adsorption was attributed to adsorbate-adsorbent interactions...
- Sintering and robocasting of beta-tricalcium phosphate scaffolds for orthopaedic applicationsPedro Miranda
Materials Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
Acta Biomater 2:457-66. 2006beta-Tricalcium phosphate (beta-TCP) scaffolds with designed, three-dimensional (3-D) geometry and mesoscale porosity have been fabricated by direct-write assembly (robocasting) techniques...
- Porous gelatin hydrogels: 1. Cryogenic formation and structure analysisSandra Van Vlierberghe
Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, Building S4 Bis, B 9000 Ghent, Belgium
Biomacromolecules 8:331-7. 2007..In both cases, the porosity and pore size decreased gradually through the scaffolds...
- The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matricesMiguel Miron-Mendoza
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9039, USA
Biomaterials 31:6425-35. 2010..collagen translocation, cell spreading and cell migration in relationship to collagen matrix stiffness and porosity. Collagen matrices prepared with 1-4 mg/ml collagen exhibited matrix stiffness (storage modulus measured by ..
- Increased plasma fibrin gel porosity in patients with Type I diabetes during continuous subcutaneous insulin infusionG Jörneskog
Departments of Endocrinology and Diabetology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
J Thromb Haemost 1:1195-201. 2003..Patients with Type 1 diabetes have a tighter plasma fibrin gel structure, to which impaired glycemic control might contribute. Improved glycemic control can be achieved with continuous subcutaneous insulin infusion (CSII)...
- A novel method for biomaterial scaffold internal architecture design to match bone elastic properties with desired porosityCheng Yu Lin
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
J Biomech 37:623-36. 2004..for initial function and appropriate remodeling of regenerating tissue while concurrently providing sufficient porosity for cell migration and cell/gene delivery...
- Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying methodX Wu
School of Science, Tianjin University, Tianjin 300072, China
Acta Biomater 6:1167-77. 2010..Scaffolds with tunable pore size and high porosity up to 98% were obtained by adjusting the concentration of the gelatin solution and crosslinking agent during the ..
- The relationship of root porosity and radial oxygen loss on arsenic tolerance and uptake in rice grains and strawX Q Mei
State Key Laboratory for Bio control, and School of Life Sciences, Sun Yat Sen Zhongshan University, 135 Xin Gang West Road, Guangzhou 510275, PR China
Environ Pollut 157:2550-7. 2009The correlations among arsenic (As) accumulation in grains and straw, rates of radial oxygen loss (ROL), and porosity of roots using 25 rice cultivars were investigated based on two pot experiments: (1) soil with addition of 100mg As kg(-..
- Multiscale modeling of fluid transport in tumorsS Jonathan Chapman
Mathematical Institute, University of Oxford, 24 29 St Giles, Oxford OX1 3LB, UK
Bull Math Biol 70:2334-57. 2008..This model is then homogenized to give a continuum description in terms of the vascular density. The resulting equations comprise a double porous medium with coupled Darcy flow through the interstitium and vasculature...
- Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixingTejas S Karande
Center for Clinical Bioengineering, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Ann Biomed Eng 32:1728-43. 2004..The importance of diffusion in scaffolds and how it is influenced by porosity, permeability, architecture, and nutrient mixing has been emphasized...
- The influence of surface porosity on gap-healing around intra-articular implants in the presence of migrating particlesOle Rahbek
Orthopedic Research Laboratory, Aarhus University Hospital, Nørrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
Biomaterials 26:4728-36. 2005..A sealing effect against the migration of PE particles was found for both Fi and Pl implants in exact fit...
- State of the art and future directions of scaffold-based bone engineering from a biomaterials perspectiveDietmar Werner Hutmacher
Division of Bioengineering, National University of Singapore, 7 Engineering Dr 1, Singapore 11757
J Tissue Eng Regen Med 1:245-60. 2007..Advantages and limitations of these materials are analysed along with various architectural parameters of scaffolds important for bone tissue engineering, e.g. porosity, pore size, interconnectivity and pore-wall microstructures.
- Preparation of porous scaffolds by using freeze-extraction and freeze-gelation methodsMing Hua Ho
Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan
Biomaterials 25:129-38. 2004..In addition to the presentation of the morphologies of the fabricated scaffolds, preliminary data of cell culture on them are as well included in the present work...
- Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT studyKyle K Nishiyama
Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Canada
J Bone Miner Res 25:882-90. 2010Increases in cortical porosity (Ct.Po) and decreases in cortical thickness (Ct.Th) are associated with increased bone fragility...
- Protecting against water loss: analysis of the barrier properties of plant cuticlesM Riederer
Julius von Sachs Institut fur Biowissenschaften, Universitat Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
J Exp Bot 52:2023-32. 2001..Open questions concerning the mechanistic understanding of the plant cuticular transport barrier and the role the plant cuticle plays in ensuring the survival and reproductive success of an individual plant are indicated...
- Porous bioactive nanostructured scaffolds for bone regeneration: a sol-gel solutionOliver Mahony
Imperial College London, Department of Materials, South Kensington Campus, London, SW7 2AZ, UK
Nanomedicine (Lond) 3:233-45. 2008..Composites provide a partial solution to this problem, although their bioactive and degradation properties are not ideal, therefore novel nanocomposites are needed. The route to these potentially ideal materials is described...
- Strategies and applications for incorporating physical and chemical signal gradients in tissue engineeringMilind Singh
Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, Kansas 66045 7609, USA
Tissue Eng Part B Rev 14:341-66. 2008..In the future, in vivo applications will shed more light on the performance of gradient-based mechanical integrity and signal delivery strategies compared to traditional tissue engineering approaches...
- Pore formation induced by an antimicrobial peptide: electrostatic effectsFrantz Jean-François
UMR 5248, Centre National de la Recherche Scientifique Université Bordeaux 1, European Institute of Chemistry and Biology, Pessac, France
Biophys J 95:5748-56. 2008..Based on the simulation of a mutated peptide and the effects of small external electric fields, we conclude that electrostatic forces play a crucial role in the process of pore formation...
- Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsulesAldo Leal-Egana
Department of Cell Technology and Applied Stem Cell Biology, Biotechnology and Biomedicine Centre BBZ, University of Leipzig, Leipzig, Germany
J Microencapsul 27:86-93. 2010..According to the author's knowledge, this is the first report of a systematic study and determination of the K(d) value for immobilized hepatocytes, incorporating a wide range of cell concentrations within the alginate matrix...
- Design of porous polymeric scaffolds by gas foaming of heterogeneous blendsA Salerno
Department of Materials and Production Engineering and Interdisciplinary Research Centre on Biomaterials CRIB, University of Naples Federico II, 80125 Naples, Italy
J Mater Sci Mater Med 20:2043-51. 2009..Along this line, this study aimed at the design of porous scaffolds with controlled porosity and pore size distribution from blends of poly(epsilon-caprolactone) (PCL) and thermoplastic gelatin (TG), a ..
- Porous bioactive scaffold of aliphatic polyurethane and hydroxyapatite for tissue regenerationLi Wang
Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People s Republic of China
Biomed Mater 4:025003. 2009..The HA/PU composite scaffold with a high HA content of about 60 wt% has a porosity of more than 78% and a pore size from 100 microm to 800 microm...
- Modulating the porosity of cryogels by influencing the nonfrozen liquid phase through the addition of inert solutesHarald Kirsebom
Department of Biotechnology, Lund University, P O Box 124, SE 22100, Lund, Sweden
Langmuir 26:16129-33. 2010..The possibility of changing the structure and properties of the gels by adding different solutes could open up new applications for these materials, for example, chromatography applications...
- Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regenerationJayarama Reddy Venugopal
Nanoscience and Nanotechnology Initiative, Division of Bioengineering, National University of Singapore, Singapore
Artif Organs 32:388-97. 2008..These fiber diameters were around 411 +/- 158 to 856 +/- 157 nm, and the pore size and porosity around 5-35 microm and 76-93%, respectively...
- Development of 3-D poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning methodTeo Jeon Shin
Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 110 768, Republic of Korea
Biotechnol Lett 32:877-82. 2010..05). Taken together, newly developed 3-D poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold is a promising candidate for bone regeneration...
- Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical boneC David L Thomas
School of Dental Science, University of Melbourne, Victoria 3010, Australia
J Anat 209:219-30. 2006This study investigated the relative contributions of pore size and pore density (number of pores per mm2) to porosity in the midshaft of the human femur...
- Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptidesMing Tao Lee
National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan
Proc Natl Acad Sci U S A 105:5087-92. 2008..The mechanism includes a negative feedback that makes peptide-induced pores stable with a well defined size, contrary to the suggestion that peptides disintegrate the membrane in a detergent-like manner...
- Impactability and time-dependent mechanical properties of porous titanium particles for application in impaction graftingL H B Walschot
Department of Orthopaedics, Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Biomed Mater Res B Appl Biomater 95:131-40. 2010..1-2.5 MPa)) were assessed by standardized impaction and a confined compression test. Loaded samples were used for particle release analysis...
- Porosity of human mandibular condylar boneG A P Renders
Department of Functional Anatomy, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, The Netherlands
J Anat 210:239-48. 2007Quantification of porosity and degree of mineralization of bone facilitates a better understanding of the possible effects of adaptive bone remodelling and the possible consequences for its mechanical properties...
- The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) filmsChengtie Wu
Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney, Sydney 2006, Australia
Biomaterials 30:2199-208. 2009....
- Cortical bone in the human femoral neck: three-dimensional appearance and porosity using synchrotron radiationValerie Bousson
Laboratoire de Radiologie Expérimentale, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
J Bone Miner Res 19:794-801. 2004..radiation allowed visualization of the 3D cortical bone microarchitecture and measurement of intracortical porosity of femoral neck cortical bone specimens from 19 female cadavers imaged at 10.13-microm resolution...
- Porosity and its effect on the digestibility of dilute sulfuric acid pretreated corn stoverClaudia I Ishizawa
Chemical and Biosciences Center and National Bioenergy Center, National Renewable Energy Laboratory, 1617 Cole Boulevard, Golden, CO 80401 3393, USA
J Agric Food Chem 55:2575-81. 2007..Prior work has shown a strong correlation between porosity, measured as the change in the volume of pores accessible to a cellulase-sized molecule, and the initial ..
- Composite fibrous biomaterials for tissue engineering obtained using a supercritical CO2 antisolvent processC A García-González
Instituto de Ciencia de Materiales de Barcelona ICMAB CSIC, Campus de la UAB s n, Bellaterra E 08193, Spain
Acta Biomater 5:1094-103. 2009..After further post-processing in a three-dimensional network, these nanofibers can potentially be used as scaffolds for tissue engineering...
- Porous polymer/hydroxyapatite scaffolds: characterization and biocompatibility investigationsTimothy Douglas
Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Strasse 16, 24105, Kiel, Germany
J Mater Sci Mater Med 20:1909-15. 2009..It was shown that PLGA-HAP composites support osteoblast growth and vitality, paving the way for applications as bone tissue engineering scaffolds...
- Specimen size and porosity can introduce error into microCT-based tissue mineral density measurementsRoberto J Fajardo
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Bone 44:176-84. 2009..Measurements of rho(m) of specimens of unequal size or quantities of bone mineral must be interpreted with caution unless appropriate steps are taken to minimize these potential artifacts...
- An alternative technique to shape scaffolds with hierarchical porosity at physiological temperatureJuan Pena
Departamento de Quimica Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Acta Biomater 6:1288-96. 2010..network of interconnected pores (300-900 microm); in addition, a random and not necessarily connected porosity is generated, yielding a hierarchical porous architecture from the macro to the molecular scale...
- Three-dimensional porous biodegradable polymeric scaffolds fabricated with biodegradable hydrogel porogensJinku Kim
Tissue Engineering and Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Tissue Eng Part C Methods 15:583-94. 2009..The pore size distribution, porosity, pore interconnectivity, and spatial pore heterogeneity of the 3D PCLF scaffolds were assessed using micro-..
- Optimising bioactive glass scaffolds for bone tissue engineeringJulian R Jones
Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Biomaterials 27:964-73. 2006..The scaffolds also have textural porosity in the mesopore range (10-20 nm). The scaffolds were sintered at 600, 700, 800 and 1000 degrees C...
- The effect of BMP-2 on micro- and macroscale osteointegration of biphasic calcium phosphate scaffolds with multiscale porositySheeny K Lan Levengood
Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, 1304 West Green Street, Urbana, IL 61801, USA
Acta Biomater 6:3283-91. 2010..The combined effect of BMP-2, a potent osteoinductive growth factor, and multiscale porosity has yet to be investigated...
- In vitro evaluation of macroporous hydrogels to facilitate stem cell infiltration, growth, and mineralizationVandana Keskar
Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL 60612 7231, USA
Tissue Eng Part A 15:1695-707. 2009....
- Tissue engineering for total meniscal substitution: animal study in sheep modelElizaveta Kon
Laboratorio di Biomeccanica, Rizzoli Orthopedic Institute, Bologna, Italy
Tissue Eng Part A 14:1067-80. 2008..Two different surgical implantation techniques in a sheep model were evaluated...
- Kinetic pathway of antimicrobial peptide magainin 2-induced pore formation in lipid membranesYukihiro Tamba
Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, 836 Oya, Suruga ku, Shizuoka 422 8529, Japan
J Phys Chem B 114:12018-26. 2010..We estimated the radius of these pores, which increases with an increase in magainin 2 concentration. On the basis of these data, we propose a hypothesis on the mechanism of magainin 2-induced pore formation...
- New insights into the pore structure of poly(d,l-lactide-co-glycolide) microspheresKerstin Vay
Sandoz GmbH, Sandoz Development Center Austria, Biochemiestrasse 10, A 6250 Kundl, Austria
Int J Pharm 402:20-6. 2010..From the envelope and the skeletal volume of the microspheres the porosity was calculated...
- Porous silicon in drug delivery devices and materialsEmily J Anglin
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0358, USA
Adv Drug Deliv Rev 60:1266-77. 2008..This paper reviews the preparation, chemistry, and properties of electrochemically prepared porous Si or SiO2 hosts relevant to drug delivery applications...
- A fibrinogen-based precision microporous scaffold for tissue engineeringMichael P Linnes
Department of Bioengineering, University of Washington, 1705 NE Pacific Street, W H Foege Building, Rm N330L, Box 355061, Seattle, WA 98195, USA
Biomaterials 28:5298-306. 2007..We present a method to create a microporous, nanofibriliar fibrin scaffold that has controllable pore size, porosity, and microstructure for applications in tissue engineering...
Research Grants79
- Osteoinductive Injectable Degradable Polymeric ScaffoldMichael Yaszemski; Fiscal Year: 2007..may self-crosslink in the absence of a crosslinking agent, (2) the use of degradable hydrogel microspheres as the porosity generating method would both improve the scaffold's injectability and eliminate the step of solid porogen ..
- Resorbable Calcium Phosphate Ceramics for Bone Graft.Susmita Bose; Fiscal Year: 2010..25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity ..
- Dental Stem Cells and Tooth Tissue EngineeringPamela C Yelick; Fiscal Year: 2010..Silk scaffold fabrication methods, porosity, degradation rates, and added growth factor peptides, will be systematically evaluated...
- IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERINGAntonios Mikos; Fiscal Year: 2002..will be tested using a three-dimensional cell/polymer model developed in our laboratory to determine the optimal porosity and pore size of hydrogel scaffolds for maximum bone formation in vitro...
- Engineering fibrin polymers for enhanced angiogenesisTHOMAS HARRISON BARKER; Fiscal Year: 2010..These poor behaviors are primarily attributed to the polymer's lack of integrin-specific ligands and proper porosity. A fibrin polymer is capable of engaging many integrins on mostly inflammatory cells;however the lack of ..
- Engineering fibrin polymers for enhanced angiogenesisTHOMAS HARRISON BARKER; Fiscal Year: 2010..These poor behaviors are primarily attributed to the polymer's lack of integrin-specific ligands and proper porosity. A fibrin polymer is capable of engaging many integrins on mostly inflammatory cells;however the lack of ..
- Delivery of LEDGF for retinal degenerative disordersUday Kompella; Fiscal Year: 2007..This study will utilize supercritical fluid technology for controlling particle porosity, LEDGF release, and residual solvent content in microparticles and immunochemical methods for assessing retinal ..
- Tissue Engineering by a Non-Biologic Skin SubstituteWILLIAM SEARE; Fiscal Year: 2005..It creates a unique, 3- dimensional, open-cell porosity most useful when made in silicone rubbers...
- Resorbable Calcium Phosphate Ceramics for Bone Graft.Susmita Bose; Fiscal Year: 2010..25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity ..
- Measuring the Efficacy of Endovascular Treatment of AAAPeter Faries; Fiscal Year: 2007..The impact of stent graft porosity on the transmission of pressure to the aneurysm will also be studied...
- Resorbable Calcium Phosphate Ceramics for Bone Graft.Susmita Bose; Fiscal Year: 2009..25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity ..
- Evaluating Low Ignition Propensity Cigarette LegislationRICHARD O CONNOR; Fiscal Year: 2007..will examine changes in cigarette design (blend, tobacco weight, circumference, ventilation, paper citrate, paper porosity, rod moisture) due to the LIP laws, and whether these changes significantly affect ignition propensity or thermal ..
- Relative Influence of Scaffold Design/Material Parameters On Bone RegenerationScott Hollister; Fiscal Year: 2007..Aim 1: Computationally design and fabricate scaffolds architectures from HA/TCP, PLLA, and PCL at a single porosity of 60% with maximal and sub-maximal permeability Specific Aim 2: Determine elastic modulus and ultimate strength ..
- Relative Influence of Scaffold Design/Material Parameters On Bone RegenerationScott J Hollister; Fiscal Year: 2010..Aim 1: Computationally design and fabricate scaffolds architectures from HA/TCP, PLLA, and PCL at a single porosity of 60% with maximal and sub-maximal permeability Specific Aim 2: Determine elastic modulus and ultimate strength ..
- Structural and Dynamical Response of Escherichia coli to Osmotic StressJames C Weisshaar; Fiscal Year: 2010..distribution of many globular proteins depends on the detailed structure of the nucleoid, especially on its porosity to proteins of different size and charge...
- Development of new elastic titanium immediate load implantsRong Wang; Fiscal Year: 2007..Phase I has two Specific Aims: 1) identify a novel approach to create porosity and high Ti-content at the surface, and 2) demonstrate desirable surface morphology and biocompatibility for ..
- Pro-angiogenic Collagen ImplantsJoseph Backer; Fiscal Year: 2004..implants, such as Apligraft TM (Organogenesis), do not hold protein therapeutics because of the required porosity of these materials...
- Bone Water and Mineralization Measured by Nuclear Magnetic ResonanceFelix W Wehrli; Fiscal Year: 2010..thinning of the cortex is partially offset by periosteal expansion, this process is accompanied by increased porosity. It is well known that increased porosity, a hallmark of enhanced bone turnover, significantly contributes to the ..
- POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHYJEAN FRECHET; Fiscal Year: 2005..of shape templates will be prepared, which use will enable the preparation of uniform 3 mu m beads with high porosity, well-defined regular surfaces, and tunable chemistry...
- The Mechanical Basis of Primary Open Angle GlaucomaMark Johnson; Fiscal Year: 2010..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
- The Mechanical Basis of Primary Open Angle GlaucomaMark Johnson; Fiscal Year: 2010..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
- The Mechanical Basis of Primary Open Angle GlaucomaMark Johnson; Fiscal Year: 2009..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
- Foreign Body Response as a Performance Metric for Implanted ScaffoldsDavid W Grainger; Fiscal Year: 2010..other requisite aspects of device in vivo performance, including tissue specific properties: tensile strength, porosity and micro-architecture, and custom defect-specific device morphologies (macrostructure)...
- Evaluating Low Ignition Propensity Cigarette LegislationRICHARD O CONNOR; Fiscal Year: 2009..will examine changes in cigarette design (blend, tobacco weight, circumference, ventilation, paper citrate, paper porosity, rod moisture) due to the LIP laws, and whether these changes significantly affect ignition propensity or thermal ..
- EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURESSundeep Khosla; Fiscal Year: 2004..volumetric bone mineral density (BMD), and assessment of bone microstructural characteristics, such as cortical porosity and trabecular connectivity ("noninvasive bone biopsy")...
- EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURESB Riggs; Fiscal Year: 2001..volumetric bone mineral density (BMD), and assessment of bone microstructural characteristics, such as cortical porosity and trabecular connectivity ("noninvasive bone biopsy")...

subset: commoncrawl


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Under-fire Seaford town clerk resigns (From The Argus)
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Under-fire Seaford town clerk resigns
Updated 8:16am Wednesday 2nd July 2014 in News
The Seaford Town Council clerk has resigned after a string of high-profile incidents at the authority.
Sam Shippen quit her role yesterday following an investigation into accusations of bullying, incompetence and infighting among councillors and staff.
A statement from Seaford Town Council said: "Both the council and Mrs Shippen accept that the matters under investigation are complex, deep-seated and difficult to resolve.
"To enable both the council and Mrs Shippen to move on from the situation Mrs Shippen has offered her resignation which the Council has accepted.
"The council and Mrs Shippen consider the matter closed and will be making no further comment. The council wishes Mrs Shippen well in the future and to thank her for the positive contributions she has made to the Town Council."
In February Norman Baker, MP for Lewes, accused the council of giving an "extraordinary amount of decision-making to the town clerk" which was "unwise and undemocratic".
Comments (14)
Please log in to enable comment sorting
8:28am Wed 2 Jul 14
Take it Personally says...
8:36am Wed 2 Jul 14
rogerthefish says...
8:50am Wed 2 Jul 14
Max Ripple says...
Nice man.
8:52am Wed 2 Jul 14
Sussex jim says...
rogerthefish wrote:Why the picture of Mr.Baker's grinning clown-like face instead of Mrs.Shippen?
Get rid of Baker as well please.
8:53am Wed 2 Jul 14
Max Ripple says...
9:30am Wed 2 Jul 14
Nosfaratu says...
Max Ripple wrote:Sounds familiar ! Indian MP's make these statements too.
Sorry,the actual lovely quote was, "I only smoke weed when I'm murdering, raping and looting." My mistake.
What is wrong with these people, have they no sense of propriety, their mental suitability must be in doubt. I am surprised that some sort of censorship has not been applied to Mr Duncan.
This is a good representation of the break down of Morality and basic human sensibility. I suggest the Stocks and a good flogging followed by dismemberment.
10:05am Wed 2 Jul 14
Quiterie says...
..... but enough of the odious Norman Baker..........
10:07am Wed 2 Jul 14
Bluebeef says...
10:26am Wed 2 Jul 14
Greenginkgo says...
11:45am Wed 2 Jul 14
Bluebeef says...
Greenginkgo wrote:Nothing to do with politics then?
In response to Bluebeef - Norman Baker is Seaford's MP, and was approached for help by residents and constituents concerned by the situation. Any action he took was entirely appropriate and well within his remit.
12:05pm Wed 2 Jul 14
getThisCoalitionOut says...
caMORON hasn't sacked one of his party - even when caught thieving. What message does this send out?
Of course they want them to be able to keep their pensions, if sacked they'd lose them.
12:06pm Wed 2 Jul 14
her professional says...
Bluebeef wrote:Of course it's to do with politics, and what's wrong with that? Interesting to hear Norman described as "nosy" when he gets involved in the affairs of his constituents, while Caroline Lucas is condemned on these blogs for not getting directly involved in every minuscule non- event that occurs in Brighton.
Greenginkgo wrote:Nothing to do with politics then?
In response to Bluebeef - Norman Baker is Seaford's MP, and was approached for help by residents and constituents concerned by the situation. Any action he took was entirely appropriate and well within his remit.
1:10pm Wed 2 Jul 14
NickBrt says...
11:31pm Wed 2 Jul 14
Withdean-er says...
Comments are closed on this article.


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NEW YORK At least two mills have increased base prices on steel plate products in a move that buyers say will likely solidify an increase pushed through last month. Nucor Corp. hiked base prices on all new orders for carbon, alloy and heat-treated plate by a minimum of $25 per ton effective immediately, it said in an Aug. 13 letter to customers. The announcement by the Charlotte, N.C.-based mill follows a leading move by SSAB Americas last week (amm.com, Aug. 9). ....
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Crisis Assistance Ministry serves low-income citizens in Mecklenburg County who are struggling to meet life's basic needs. The organization has received a number of grants the Critical Need Response Fund, a Center For Civic Leadership initiative to meet increased demand among human services organizations due to the economic crisis.
The Center for Civic Leadership at Foundation For The Carolinas enjoyed a banner year in 2009, responding to demand from the community in a number of arenas. Among these efforts: driving initiatives to enable our nonprofit sector to become more stable and effective; improving workplace giving campaigns across the corporate sector; mitigating the crisis faced by human-services organizations due to the economic downturn; and working on other issues of importance to our community, such as affordable housing.
The Center was established in 2008 to institutionalize Foundation For The Carolinas' position as a change agent and problem-solving partner in the Charlotte community. The Center is charged with the task of identifying key community challenges, and engaging Charlotte's leaders and citizens in the development of solutions for the long-term betterment of the community. Highlights of Civic Leadership activity appear below.
The first Critical Need Response Fund was launched in 2008 to help nonprofits meet the "critical" winter needs of the community, as the onslaught of the economic downturn simultaneously depressed funding, while increasing demand for services. In late 2009, it became clear the need was greater than ever, and area donors asked the Foundation to again lead the effort to fill the gaps.
The Workplace Giving Task Force was created to determine the most productive and effective means of supporting our nonprofit community through workplace giving campaigns. Many factors indicated the need for a focused and candid study to determine the value of such campaigns to the community, and to identify the best practices for improving results. In collaboration with the United Way of the Central Carolinas and Arts & Science Council, Foundation staff convened thought leaders representing 11 organizations with workplace campaigns to consider the issue. The task force will release its report to the public in 2010.
The Community Catalyst Fund was established to inspire and enable innovation, collaborations, partnerships and mergers in support of the successful sustainability of Charlotte's nonprofits in the wake of a decrease of funding support and investment returns caused by the economic downturn. The group's achievements to date include a groundbreaking study of our nonprofit sector, several important outreach efforts to educate and engage the community, a nonprofit education initiative for groups within sectors, and more than $749,000 in grants awarded across multiple organizations.
Formally established in 2008, The Center for Civic Leadership continues the Foundation's work of identifying key community challenges, and engaging Charlotte's leaders and citizens in developing long-term solutions. A generous group of donors supports the work of the Center, which is carried out by Foundation staff who work with community volunteers to address issues.


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Alan Pardew was as upbeat as he could be in his press conference today, but he did say it's been a tough week in training but the lads have done well on the training ground this week.
Alan Pardew – we're back to work – building up our confidence
This is some of what Alan had to say today:
"We're up against a very very good side and we have to make sure we have to defend well but we also have to offer a threat."
"We've worked well on the training ground this week." "It's been a disappointing week as you can imagine, but still we've worked well this week."
"We're back to work and now and building our confidence up." "It's now about getting us and our position in the league more secure and my job is the next game, and that's what I'm focusing on."
Alan also said that a manager's job these days is not on the financial side of transfers, and he hasn't been involved on the financial side of transfers for at least seven years, and that's probably the way it should be.
English football is now following the continental model, where the manager is basically the coach and his job is to get best out of the players he has available.
The Director of Football and higher-ups in the club deal with all the transfers into and out of the club.
Newcastle need to get their confidence up and try to win one of their next two games, either at Chelsea (impossible?) or at home to Tottenham, and that would help raise the spirits of the Newcastle fans, who are not too happy at the moment.
And we still cannot believe the incompetence shown by the club last week, but I'm sure we'll get over it – but it may take a little time.
Comments welcome.
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Swick (14-2) had been scheduled to face off with Martin Kampmann at UFC 103 for the right to face St. Pierre, but suffered a concussion in training about two weeks before the fight. The UFC brought in Paul Daley to replace him, and the debuting Brit upset Kampmann with a first-round TKO, shaking up the title picture.
Hardy most recently defeated Marcus Davis at UFC 99, and was expected to follow up that outing with a UFC 105 bout against unbeaten Korean Dong Hyun Kim. That match, however, is expected to be scrapped. Hardy (22-6) has been perfect in his three forays into the octagon, besting Rory Markham and Akihiro Gono in addition to Davis.
White told FanHouse that the Swick-Hardy matchup is not yet finalized, but expects to make it official shortly. He made no indication as to which event will host the bout, but UFC 105 seems like the logical choice as both Hardy and Swick have recently spent time in training camps.
St. Pierre, meanwhile, is on the shelf until early 2010. Last month his manager Shari Spencer told FanHouse that GSP was targeting a January return from a groin injury, but a Swick-Hardy November matchup would likely give him even more time to recover before returning.
St. Pierre, the consensus top-ranked welterweight in the world, has won six in a row, winning the UFC interim title in December 2007 and capturing the undipsuted belt with an April 2008 win over Matt Serra. He is 19-2 overall.


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2013 Annual Report
ABOUT ILSIThe International Life Sciences Institute (ILSI) is a nonprofit, worldwide organization whose mission is to provide science that improves human health and well-being and safeguards the environment.It achieves this mission by fostering collaboration among experts from academia, government, and industry on conducting, gathering, summarizing, and disseminating science. Read More
NEWS!Nutrition Reviews Moves to #5Nutrition Reviews is now #5 for impact factor (Nutrition and Dietetics)! Congratulations to Editor Naomi Fukagawa and her team. Also, enjoy a special online-only issue on material and infant nutrition. No charge and no subscription required: Maternal and child nutrition
New Publications on Nanomaterials and the Food SupplyThe ILSI Research Foundation and ILSI North America are pleased to announce six new open-access publications are now available. The list of papers and links are on ILSI North America's website: Nanotech and the Food Supply
Have you heard about the peanut butter recall due to possible Salmonella contamination? ILSI North America recently published a paper on ways tokeep processing equipment clean in Food Microbiology. The paper isOpen Access: Peanut Butter Processing Equipment.


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As marketing and business professionals, we've all been there... Big presentation, large groups of people, a lot of pressure... How am I going to remember my key points?
Last weekend, former US vice-presidential candidate Sarah Palin was the featured speaker at the Tea Party Convention in Nashville, TN. Later in the day, during a question and answer session, to remember her key points she snuck a look at notes she had written in ink in the palm of her hand.
Let's see what she had written.
[Fig. 1 Sarah Palin's Hand]
It reads:
- Energy
- Budget cut
- Tax
- Lift American Spirits
Below are five methods to avoiding what happened to Sarah.
Ways To Remember Short Lists
What happened to Sarah could have happened to any of us. As a manager, a marketer having to influence people, stay on top of the issues, and remain confident are expectations of our roles. You are the expert - if you don't know it, who does?
1. Mnemonic Device: Acronym
Create an acronym or phrase out of the key words. For example, I remember the colors of the rainbow from the name "Roy G. Biv" (red, orange, yellow, green, blue, indigo, and violet).
Perhaps Palin could have used BELT. (Budget, Energy, Lift, Tax)
2. Mnemonic Device: Short Sentence / Story
Alternately, she could have made a short sentence - almost a short story - about the topics. Perhaps...
Spend Energy Lifting Not Taxing
All the key words are there in a simple sentence.
3. Learn It
Some criticize Sarah for needing notes at all to answer the basic question. As a subject matter expert, this information, her 'elevator pitch' for change, should roll off her tongue. (After all, it's only four items).
As a marketing or business lead your colleagues, operations team, agency, et al are looking to YOU to be the expert.
4. Note Cards
There's nothing wrong with using notes and note cards. Nobody is expected to remember everything.
The two main issues with what happened to Sarah were:
- Earlier in the day she referred to the Tea Party movement as being "much bigger than any charismatic guy with a teleprompter."
- She tried to sneak a look - and got busted. She pretended to know. She would have been better off simply carrying and openly referring to notes.
She would have been fine if she had her list written in LARGE PRINT placed flat on the table next to her water.
[Fig. 2 Table Would Have Worked For Note Cards]
5. To-Do Tattoo
Finally, if you MUST write on your hand - do it properly.
[Fig. 3 To-Do Tattoo]
Use the To-Do Tattoo - "the perfect solution for your shoddy short-term memory."
It is a temporary tattoo with lines, and a skin-safe washable gel pen. You can have Amazon deliver one.
Unfortunately, we now have a new word in the Urban Dictionary: the "redneck teleprompter."
What techniques have you found helpful to recall important information while under pressure?


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TOKYO—At a press briefing today Keiichi Nakagawa, a radiologist at University of Tokyo Hospital, predicted that the radiation emanating from the damaged Fukushima nuclear power plant will have a negligible effect on public health. But those working to contain the radiation leaks and quench the fires face an increased risk of cancer, particularly since the government raised the allowable exposure limit yesterday.
Nakagawa said that normally nuclear power plant workers in Japan are limited to accumulated radiation doses of 100 millisieverts. But as an emergency measure, the ministry of health on Tuesday raised that to an accumulated 250 millisieverts. Nakagawa says that at that higher level of exposure, the workers will likely face a 1% or more increased risk of cancer. "It's only a risk, but they are now carrying a heavier risk of cancer," he said.
Radiation levels of 400 millisieverts per hour were recorded within the site on Tuesday. But workers are wearing protective clothing, working in brief shifts and being occasionally pulled off the site to limit accumulated exposure.
Nakagawa explained that the situation in the local community is significantly different.
Residents have been evacuated from within 20 kilometers of the stricken power plant and those between 20 and 30 kilometers away have been warned to stay indoors. Radiation within the 20- to 30-kilometer belt has been 10 to 20 microsieverts per hour. But indoor levels are likely to be just one-tenth of outdoor levels. At 1 microsievert per hour, it would take 11 years of exposure to get an accumulated dose of 100 millisievert, a level that can cause an increased risk of cancer. "For the general public, definitely there will be no health impact," he said. And for those as far away as Tokyo, he said that he "wouldn't be worried" even in the case of a core meltdown.
In 1999, Nakagawa was involved in treating two employees of JCO, a nuclear fuel cycle company, whose mishandling of uranium resulted in massive doses of radiation. Both employees eventually died. Nakagawa said that an accumulated dose of 4 sievert kills 50% of those exposed within 60 days. A dose of 1 sievert produces nausea and vomiting. Accumulated exposure of more than 250 millisieverts can cause the loss of white blood cells, and exposure of 100 millisieverts produces an increase in the risk of cancer of about 0.5%.


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2004 Chevy Tahoe. Fully loaded, very cold air, excellent condition. 157K miles Runs and drives good. $6000obo
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2004 Mustang GT Premium, black, short throw 6 speed, all leather interior, new tires, many options. Super sharp car in like new condition !! $7500. 217-840-3206
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I interrupt the funeral for LSU's 2009 football season and Les Miles's tenure as coach to pose this question: what if we win at UGA on Saturday?
UGA is a good team. They aren't nearly as good as recent UGA teams that won the SEC and went to BCS games. They are 3-1 and 2-0 in the SEC. They opened the season with a 24-10 loss at Oklahoma St. They hung in for the first half and were in a fog in the second half. In the following two weeks they won defense-optional shootouts against South Carolina and at Arkansas--the two classic "scrappy" SEC teams who always seem to be a bit less talented, but dangerous and difficult to beat. Last week they beat Arizona St. at home with a field goal on the last play.
UGA fans have less to be happy about than LSU fans. Their schedule has been harder, but they already have a loss and their defense has been lit up repeatedly. If we're wondering why we only beat Washington by 8 and needed a goal line stand to squeak by MSU, they're wondering how South Carolina and Arkansas managed 37 and 41 points on their defense. So, our team has issues; so does UGA. They are beatable, and we're good enough to beat them if we play well. It will certainly take our best game of the year. Fourtunately, that's not a high standard to surpass.
But if we win, then the people who say we don't belong in the top 10 are going to have to stuff it. Ditto the morons saying Miles is done.
Geaux Tigers!


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The Ohio State Highway Patrol is on the scene of a multiple-vehicle accident on the Ohio Turnpike.
All three lanes of westbound traffic near mile marker 89, just west of Fremont, are shut down due to the accident.
OSHP says they were attempting to pursue a speeding vehicle for several miles at a high rate of speed. Officials say the vehicle was traveling between 125 and 150 miles per hour, and it hit at least three other vehicles over the course of 17 miles.
One of the final vehicles hit was a van from Toledo, which burst into flames as a result of the crash, around 7:15 p.m.
OSHP says both occupants of the van were killed.
The driver of the speeding vehicle is a 24-year-old male from the Kent, OH area, who was taken to the hospital with minor injuries.
The suspect was driving at 2013 Infiniti M56.
The Turnpike was closed for several hours following the accident but has since been reopened.
Toledo News Now has a crew on the way and will update the story as more information becomes available.
Copyright 2013 Toledo News Now. All rights reserved.
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I was concerned about the Panthers game. They are a talented team and should have a much better record, but Delhomme kept losing the games for them by his stupid mistakes. The Panthers got smart and didn't make Delhomme do too much against the Cardinals, and the Cards couldn't get much done to force the issue. Panthers have a good defense and a good running game, and if Delhomme doesn't need to throw too much then they can play with anyone.
Nevertheless, it is a disappointing loss and I have mentioned that I thought this game would be more or a barometer of where the Cards are than the Giants game. So what have I learned... The Cards are pretty much what I thought; (no Denny Green reference intended), a 9-7 or 10-6 team that will still likely win the division. Actually the Cards have the exact record I thought they would have after 7 games, I just had them losing to the Giants and beating the Panthers.
As odd as it sounds, this game wasn't that significant in the big picture, (the Giants win gave them some cushion). I realize all wins are important and you nenver know what game will be significant until the end of the season but in the NFC West the key is to win the division games. I really think the key to the season will be to sweep the remaining division games, all games they should win given the Cards' talent level. If they are able to win their division games that would put their win total at 8. By my thinking then they would need to win 1-2 more games outside the division to win the division; Detroit and/or Tennessee come to mind.
If they lose any more division games then obviously they will have to make up the difference outside the division and that increases the level of difficulty to make the playoffs. Although I honestly think that the Cards can beat any of the teams outside of the division left on their schedule, (Bears, Vikings, Packers, and the fore mentioned Titans and Lions), wins within the division is what is paramount.
The loss to the Panthers frustrates like any loss but the Panthers are a good team and they have a lot of talent, more than any other team in the division and more than any other team on the horizon, except Packers and Vikings. I do not think the sky is falling. It was just one of those games.
Now if the Cards lose to Seattle, St. Louis, or San Fran then I may start to get nervous.


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I am this week's Makeup for the Weekend challenger, and my challenge is to use 5 embellishments; they can be all the same or all different.
I used Mercy's sketch from last week, MTSC68 for the layout of the card and paired that with some lovely Basic Grey goodness. I knew I wanted to use this piece of cake from Guilty Pleasures for my focal point. I adore the blue cardstock, Cool Caribbean from SU (I believe). I think I only have a few more sheets of it remaining and will have to find a replacement for it because I just love it.
I hope you can find some time to play along with us this week, the challenge is an easy one! Just be sure to use the keyword M4TW24 when you upload to any public gallery; then link it to the PMS blog so we can all take a look!
Friday, April 16, 2010
My Makeup for the Weekend
Labels: Basic Grey, Cards, Guilty Pleasures, MTSC, Nestabilities, Paper Makeup Stamps
6 comments:
- ~amy~ said...
Such a delish card Tina!!
- April 16, 2010 at 12:19 AM
- Lisa M. (aka. Lisabee) said...
You know I think I have that same cupcake paper! Love the card!
- April 16, 2010 at 9:28 AM
- Christi said...
Such a yummy card!! :)
- April 16, 2010 at 9:53 AM
- Lisa Foster said...
This is adorable! Love the colors and the cupcake paper it darling!
- April 16, 2010 at 4:40 PM
- Deb Neerman said...
Cake, yum! I love it! Oh. And the card is pretty fantastic, too!
Lol, I kid, but seriously, this card is just adorable! I love that bright and cheerful color combination and that delicious lookin' DP.
Have a great weekend, Sweetie!
- April 16, 2010 at 6:00 PM
- alienanessa said...
Delightful! Your cake shading is top notch!! The papers are wonderfuuuuuuuuul!!
- May 1, 2010 at 3:56 PM
Subscribe to: Post Comments (Atom)


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Brickell on the River 2106 in Miami Beach
- bedrooms 1
- baths 1½
- sleeps 4
- pool yes
- hot tub yes
- pets allowed no
- type House
- community
rates (USD)
/ week
$ 2,380 - $ 4,900 / month
vacation rental description
Modern two story 1 bedroom loft in Brickell, light, bright and open high rise with spectacular views that sleeps 3-4.
About Miami and Beaches Vacation Rentals - Brickell on the River 2106
Two story loft, 1 bedroom 1.5 bath with jacuzzi that is elegantly furnished. Located in the heart of Brickell on the 11th floor in a high rise building. Views of the city and river that are equivalent to the 40th floor of a standard residential building. Modern designer touches with white oak hardwood floors thoughout. Open kitchen with granite counter-tops, stainless steel appliances, and european wood cabinets. Living area has a convertible couch and a flat screen TV, loft bedroom houses a queen size bed, sitting area and a desk. The bathroom has a tub/shower enclosure with double sinks and plenty of counter space. This loft includes a parking space, internet and cable for your convenience.
This property has two landscaped pools and a sun deck on the 11th floor overlooking the river, downtown and Brickell. There is a fitness facility with free weights, circuit training and cardio equipment. If weights are not your thing, enjoy a good workout in the aoerobic studio. Once you give those muscles a workout, relax in the steam rooms, seething saunas and whirlpool spas overlooking the river. The fitness center has lockers and dressing areas for your convenience. The building is elegantly designed with modern touches in the lobby and clubroom. 24 hour concierge and valet are available.
This great loft home is located on the southern banks of the Miami River and walking distance to Mary Brickell Village with all its shopping and restaurants. The Fifth Street Metro-Mover Station is located immediately adjacent to the building for easy access to the metrorail. You are close to everything in Brickell and a short drive to Miami Beach and all the South Beach fun! Shopping, resturants or bars on Lincoln Ave or Ocean. White sandy beaches for a fun day in the sun. Or you can go into downtown Miami to catch a sporting event, nightlife or concert. Whether you are here to enjoy the crazy nightlife or want a quiet getaway from home, this is the perfect place to get the best of both worlds in style!
contact owner for availability
Heather Garden 5613987228
house rental amenities
Parking: Garage, Dogs: No, Cats: No, Smoking: No, Minimum Age: 25, Floor Area: 913 sq ft.
Amenities: Air Conditioning, Balcony, Coffee Maker, Dishwasher, Fitness Room, Full Kitchen, Hair Dryer, Ice Maker, Internet, Iron and Board, Microwave, Refrigerator, TV, WIFI, Washer/Dryer in unit, Water View.
vacation rental rates
Base Rate Non-seasonal trips $1,050.00 /Week $2,660.00 /Month
Security Deposit: $750
Rental Deposit: 35%
Cleaning Fee: $100
Minimum Stay: 13 Nights
Mar 16 - May 31
$1,050.00 /Week $2,520.00 /Month
Minimum Stay: 13 NightsSummer
Jun 1 - Aug 24
$1,000.00 /Week $2,380.00 /Month
Minimum Stay: 13 NightsFall
Aug 25 - Oct 31
$1,000.00 /Week $2,380.00 /Month
Minimum Stay: 13 NightsWinter
Nov 1 - Mar 15
$1,050.00 /Week $2,660.00 /Month
Minimum Stay: 13 NightsThanksgiving
Nov 16 - Nov 27
$1,225.00 /Week $3,500.00 /Month
Minimum Stay: 13 NightsChristmas/New Years
Dec 20 - Jan 6
$1,400.00 /Week $4,900.00 /Month
Minimum Stay: 13 Nights
Heather Garden 5613987228
payment methods
Owner has not provided their accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center


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WIndows 8 tablet success at the expense of loss in Desktop market share?
Here's a an idea about Microsoft's current strategy. Microsoft and whole industry believes that touch input based hardware and software is the future. Microsoft is betting on this big time with windows 8. We all know that in order to be successful in today's tablet/smartphone market where Apple and Google are clearly dominant players (Google to a lesser extent), a developed ecosystem is very important. This is the reason Nokia went windows phone. This is the reason RIM is unlikely to succeed with BB10. And this is the reason Android is a failure in tablet market.
Here's what I think. Microsoft knows all this very well and that's why they decided to put metro on desktop. We don't know whether Windows 8 tablets will be successful or not yet. We don't know how many of them will be sold to consumers. So there's little incentive for developers to target that audience just yet. But what we do know is that Windows 8 based PCs will be sold in hundreds of millions. And developers will want to tap that market. No wait. They will HAVE to develop for Windows 8 desktop in metro as is evidenced by the fact that BIG players like Mozilla, Google, Netflix etc. are already working on their metro apps for Windows 8. Once metro desktop apps have been developed, there's little reason not to port them on Windows RT (and similarly WP8). By putting metro on desktop, Microsoft has essentially made sure that no matter what there will be apps (and an ecosystem) for windows 8. Within an year, you can expect to have at least 100,000 metro apps in marketplace. This will result in a better app ecosystem for Windows RT and subsequently WP8.
To sum this up, Microsoft might lose some desktop customers in the short run (new ones will definitely be buying Win 8 machines. It's the current users that might not upgrade) but in the long run, Microsoft has ensured there'll be more than enough incentive for customers to buy into the Windows ecosystem.


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PLATTSBURGH — Carissa LaPier waited nervously outside a Clinton County courtroom, her graduation from a grueling program at last at hand.
She had been working toward the milestone for more than three years.
"I never thought this day would come," she said. "It saved my life. Without (Clinton County) Mental Health Court or any of my supports, I'd be sitting in jail right now."
The program offers the strict guidance of a team that includes members from both law enforcement and mental-health treatment. Participants are required to stick to a treatment plan, take medications as ordered and, among other rules, report in on a regular basis.
"It's been rough, and it was hard work," Carissa said.
By her side were her mother, Clare, her sister Camille and a friend, Tonyea Ellis.
"It's quite emotional for all of us," Clare said. "It's been a long process."
"I'm very proud of Carissa's achievements," Camille said. "I'm glad to see her smile and get through it finally."
Ellis agreed.
"She's overcome a lot of barriers and challenges."
Carissa's other sister, Rosie, and her father, David, could not be at the ceremony but have offered unwavering support to Carissa in her journey to graduation, Clare said.
Because Carissa was older than 18 and legally an adult, it was hard to find help for her when she needed it most, Clare said.
"It really took her getting into trouble to get her help," she said.
In 2009, Carissa pleaded guilty to first-degree reckless endangerment, unlawful interference with a railroad train and fourth-degree criminal mischief. She was sentenced to five years probation.
She hopes to put all that behind her once her probation expires in 10 months.
Doctors at various times diagnosed her with attention deficit hyperactivity disorder, obsessive-compulsive disorder, anxiety and personality disorders.


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Abe-Putin relationship of trust can help advance territorial talks
Japanese Prime Minister Shinzo Abe met with Russian President Vladimir Putin on Feb. 8, the day after Abe attended the opening ceremonies of the Winter Olympic Games in the Russian city of Sochi.
The leaders of major European countries and the U.S. were absent from the ceremonies, primarily on the grounds of Russia's poor human rights record. But Abe dared to attend. The action underscores the importance Abe places on enhancing the personal relationship of trust between him and Putin.
This was the fifth top-level meeting between Japan and Russia in the little over a year of Abe's current term as prime minister. This year will likely see even more dialogue between the two leaders. At this latest meeting, Abe and Putin agreed to meet again in June on the sidelines of a summit of the Group of Eight industrialized nations, which will also take place in Sochi. Putin also plans to visit Japan this autumn.
These frequent contacts between the two leaders benefit Japan-Russia relations. Cooperation between the two countries economically and in terms of national security are deepening in particular. Conditions in Northeast Asia are becoming increasingly uncertain, given China's rising military spending and North Korea's nuclear development, among other destabilizing factors. This makes it important for Japan and Russia to bolster their ties, including those of security.
From the top down
One concern is the territorial dispute between the two nations over the four islands north of Japan's Hokkaido island. Putin appears eager to resolve the dispute and conclude a Japan-Russia peace treaty. At the Sochi meeting, he noted that a "good environment is being created for solving the toughest problem between Japan and Russia."
At present, however, there is no sign of progress being made in the negotiations on sovereignty over those northern islands. Russia adheres to its claim that it acquired the islands as its territory as a result of World War II. Japan calls for confirmation that the islands belong to it. The gulf between the two over this remains profound.
Tokyo and Moscow have started vice-foreign-minister-level meetings to discuss the territorial issue. The goal is to figure out a solution acceptable to both sides. The latest of these get-togethers was held in late January, but the only result was to further illuminate just how wide the gap is in the positions of the two nations.
Moving Japan-Russia relations forward comprehensively, which would include economic issues as well as security, is important in that this would improve the environment surrounding the territorial negotiations. It would be problematic if the territorial issue were left behind as other issues took the spotlight. Putin's choices will be vital in resolving this issue. Making the most of the relationship of trust between the Japanese and Russian leaders, the two countries should also seek a breakthrough on the issue that starts from the top.
At a press conference just after his meeting with Putin in Sochi, Abe said, "Efforts must be made to solve the territorial dispute between the two nations as early as possible," expressing his resolve to do so. Wisdom from all sides should be brought together to move the territorial talks forward.