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In June of 2009, President Obama went to Cairo to give his first major foreign policy address as president of the United States. In it, the president outlined his administration's agenda for dealing diplomatically with other nations, confronting terrorism, and "restoring" America's standing in the world.
In essence, Obama made the case that America should be less aggressive militarily, offer softer rhetoric, and make an attempt to be more "liked" by other nations.
By any fair assessment, this approach to foreign policy has failed, and the Obama administration has been exposed as naïve, soft and equivocating in terms of promoting American leadership.
The most recent manifestation of this is seen through events that have unfolded in a big way from a small country, that country being Syria.
One would be hard pressed to find someone not deeply troubled by recent developments concerning Syria and the government of Bashar Assad. It can be said with certainty that his government used chemical weapons on its own people, which lead to the death of over 1,400 Syrians, including women and children.
It seems incredible that something like that could happen in today's world, and equally hard to believe that the rest of the world, especially the United States, could remain silent. Of course, no one president,or political party is to blame for the Syrian government gassing its own people. The person to blame is Bashar Assad.
However, Obama has an obligation to promote civility and America's interests as leader of the free world, a job he actively sought, and he has acted without principle, purpose or vision.
The crisis in Syria is certainly not something that snuck up on the administration; the civil war has been going on for two years. By doing nothing besides offering passive statements of condemnation, without any force behind them, the president allowed emboldened Assad and allowed his government to continue its despicable acts when they were most vulnerable.
At the time, though, "Bin Laden was dead and GM was alive," so in terms of Obama foreign policy, all was right in the world. Perhaps if we had acted earlier and more decisively, the rest of the world would have come to aid the opposition and Assad's government could have been overthrown.
However, that support never came and a power vacuum was created in which elements of the opposition became radicalized and there is legitimate concern about their connections to Islamist, militant groups.
That leaves us with few good options in Syria in the present. Obama has called Congress to vote on an authorization allowing a military strike in Syria, even though he has said he will use force whether the measure passes Congress or not, and even though as commander in chief, he has military power at his disposal. In doing this, or "playing constitutional theater" as Sen. Rand Paul has referred to it, Obama has undermined his own power as president and has narcissistically put the onerous on a Congress where both parties are divided.
From blaming Bush to ATM's to everything in between, it is clear that the buck never stops with this president.
In addition to these rhetorical blunders, the president has failed to lay out a compelling case as to how using military force would critically damage the Assad regime and be in our nations self-interest. The president has said that his conscience is bothered by Syria's use of chemical weapons (as if ours aren't) but that is not a strong enough reason to use military force.
Firing missiles for the sake of firing missiles to make it appear like you are doing something about the problem would not only not solve anything, it would have a detrimental effect. If the president, his security team and generals can find a way to use our military and aid the opposition in a way that would cause Assad to surrender, show Iran and other hostile neighbors that these acts cannot go unpunished and bring some sense of stability to the region, then a military strike is undoubtedly in our national interests.
If they cannot do that, Congress and the American people will remain unconvinced.
In Syria, we have seen Obama's foreign policy at its worst. Wavering and weak, it is clear that Obama made a serious miscalculation in thinking offering a conciliatory tone would cause our enemies to stop hating us or doing despicable things.
If the United States does not demonstrate to the world a very clear sense of what is acceptable and what is not, then no one will. Because of this, the Syrian people, and America's standing in the world, have paid the price. So much for being liked.


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Gun rights activist and musician Ted Nugent claimed in a radio interview on Monday that he killed more than 450 pigs with a machine gun while shooting from a helicopter. According to the website RumorFix, Nugent made the claim in an interview with Brett Winterble on Sirius XM Radio and said that he dedicated the kill to HBO host Bill Maher and "all those other animal freaks out there."
"I took my machine gun in the helicopter — in the Texas hill country – me and my buddy 'Pigman' … his name is 'Pigman' – I'm the swine czar," said Nugent. "I killed 455 hogs with my machine gun. i did it for Bill Maher and all those other animal rights freaks out there."
Boasting that the weapon he used fired 750 rounds a minute, the right-wing provocateur said, "My haters will hate me more for that."
According to the Associated Press, the state of Texas awards prize money during an annual three-month event in which hunters are urged to kill as many feral pigs as they can. The animals have bred out of control in the Texas wilderness and cause millions of dollars in crop and property damage every year.
"We saved the environment from the destruction of these out-of-control pigs," said the Michigan-born rocker, "and I'm not talking about Washington D.C. or San Francisco … I'm actually talking about actual pigs."
He went on to say that "we distributed tons of the most delicious pork to the soup kitchens and homeless shelters of this state. Everything we did was perfect – win win win. I had to adjust my halo as I was machine gunning hogs."
By Katie Halper
By TBogg
By Amanda Marcotte
Raw Story is a progressive news site that focuses on stories often ignored in the mainstream media. While giving coverage to the big stories of the day, we also bring our readers' attention to policy, politics, legal and human rights stories that get ignored in an infotainment culture driven solely by pageviews.
Founded in 2004, Raw Story reaches 9 million unique readers per month and serves more than 30 million pageviews.
Copyright © 2004-2013 Raw Story Media, Inc. All rights reserved.

subset: commoncrawl


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"The playoff run was an awesome experience," he said. "We took one game at a time and stayed confident. Winning the state title was a dream come true and I can't explain in words how it felt raising the trophy."
Pougnet is an athletic 6'3, 180-lber who really turned it on late in the season, particularly in the state title game. In a 56-26 win over Lansing Catholic Central (who beat them in the regular season), Pogunet went 12 for 15, 258 yards and four touchdowns. He rushed for 155 yards and two scores on 14 carries.
He says the turnaround for him, his team, and his offense, came from a simple addition that made all the difference.
"We added a tight end into our offense which really opened things up in the middle and gave our wide outs more room to work with. Also, our receivers got better each game in the playoffs as well and I became more and more confident each game."
Right now, Pougnet says the schools he is hearing from are Western Michigan, Ball State, Syracuse, Stanford and Princeton.
He finished the season with 1,523 yards through the air, and exactly 1,000 yards rushing. He scored 27 total touchdowns.


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News: Big Sean Says Fans Have No I.D.ea How Hard "Finally Famous" Will Hit
Friday, Mar 11, 2011 3:40PM
G.O.O.D. Music's Big Sean recently discussed his upcoming Finally Famous debut, and why enrolling No I.D. to produce the LP is his way of pulling a fast one on the rap game.
Revealing a few of the guest features, Sean detailed how much of an impact No I.D. will have on his project.
"The title as of now is gonna be called Finally Famous," Sean said in an interview. "I may at the last minute add a subtitle to it because that's also the name of my mixtape series I did. That's something I really wanna brand as a lifestyle because that's what I believe in. When you're famous you're recognized for doing something, and I always put finally in front of it because I feel like this sh*t's what we've been grinding and working for all these years, and that can relate to anybody. As far as production majority of it was done by No I.D. which I feel is not even fair because he's just so d*mn good and he's such an O.G. and he's seen music come full circle. He really has a great perspective on music and is definitely one of my mentors." (XXL Mag)
No to be outdone, Sean also recruited Kanye West and Pharrell Williams to contribute.
"Of course Kanye put his foot in it and Pharrell put some work in," he added. "As far as features Mike Posner's on there, The-Dream and a couple [of] others but not too many features. I really wanted to keep it to the story of my life from someone realizing what they wanna do, and starting to live out their dreams, and falling in and out of love, partying, and sh*t people can really relate to. It's real life sh*t that people are gonna be able to smoke to, cry to, have sex to. That's really the best type of music period." (XXL Mag)
The project will finally arrive in retail stores around early May.
Looks like Big Sean's anticipated album, Finally Famous, will be coming out on May 3rd, 2011 via G.O.O.D. Music/Def Jam. He also confirmed that Kanye, Mike Posner, and Pharrell will all make appearances. Another interesting note is that he mentions a mixtape should be dropping before the album, to make sure the buzz is right. (MOG News)
Last month, reports claimed the album would drop in late March.
Big Sean commanded listeners' attention earlier this week with the debut of his Chris Brown-assisted single "My Last," and now his debut album finally has an official release date. The G.O.O.D. Music rapper will drop his first studio LP Finally Famous: The Album on March 29, Rap-Up.com has learned. He will face competition from his hip-hop peers Wiz Khalifa (Rolling Papers) and Snoop Dogg (Doggumentary), among others. (Rap-Up)
Big Sean's Finally Famous is set to drop Tuesday, May 3rd.
Check out some recent Big Sean down below:


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It's the same dilemma we face every March in the NCAA Tournament: do we root for crazy upsets early on, even if it means lesser matchups in later rounds? Do we root for that 16-seed to finally take out that 1-seed, even if it means they will likely get smoked in the second round? Or do we grit our teeth and hope for chalk so that it's heavyweight-versus-heavyweight in the second week?
Personally, I tend to root for upsets despite myself. But in this year's Aussie Open, we get to see what happens when most of the favorite slip through to the second week, especially on the men's side. We have two quarterfinal matchups so far: Rafael Nadal vs. Tomas Berdych, and Roger Federer vs. Juan Martin del Potro. (And even if Berdych gets crushed by Nadal, as he typically does, that match will have extra entertainment value after Berdych got booed off the court on Day 7.) We love the Cinderella story -- Michael Chang at the French in 1989, qualifier Boris Becker at Wimbledon in 1985 -- but the slipper rarely actually fits. And if things go according to plan today, we could be looking at another pair of wonderful men's quarters, and some killer women's matches as well, like Wozniacki-Clijsters and, potentially, Williams-Sharapova.
No. 1 Novak Djokovic vs. Lleyton Hewitt
Rod Laver Arena, Match No. 5
If there is a Cinderella story left in the draw, it is the 30-year old Hewitt, who took out up-and-comer Milos Raonic in the third round to get a chance at Novak Djokovic. While I can talk big about a potential Djokovic-Murray or Djokovic-Tsonga semifinal, followed by, of course, a finals matchup versus either Roger Federer or Rafael Nadal, it would still be incredible to see Hewitt give the world's current untouchable No. 1 a run for his money.
Of course, that isn't bloody likely. Djokovic has lost 10 games in nine sets at the Aussie Open thus far. He is, in a lot of ways, Hewitt 2.0. A little taller, a little faster, a little better defensively, and, at this stage, much better offensively. An incredible old-versus-new match here would be fantastic, but it is difficult to expect it.
No. 4 Andy Murray vs. Mikhail Kukushkin
Rod Laver Arena, Match No. 2
Mikhail Kukushkin is the tournament's marathon man thus far. The 92nd-ranked, 24-year old from Kazakhstan took out Viktor Troicki in five sets on Day 4, then knocked off your little brother Gael Monfils in five more sets on Day 6, blowing a two-set lead, then winning 6-4 in the fifth. He has won five of his last six tour matches, easily the most successful recent stretch of his career. His one loss in this span: to Murray a couple of weeks ago in Brisbane (5-7, 6-3, 6-2). He can take solace, however, in the fact that he took a set from the world No. 4. He created almost as many break points (seven) as Murray (nine), and the overall difference in the match ended up being about six points. Not bad.
In their lone meeting, Kukushkin was eventually done in by his second serve. He won 70 percent of his first serve points (Murray won 71 percent of his), but he only got his first serve in 53 percent of the time (Murray: 61 percent) and only won 41 percent of his second-serve points. Murray is known for his counter-punching ability, but he is also an excellent returner, and if Kukushkin cannot keep him off balance, he will be broken quite a bit.
Other matches: No. 6 Jo-Wilifried Tsonga vs. No. 24 Kei Nishikori, No. 5 David Ferrer vs. Richard Gasquet.
No. 2 Petra Kvitova vs. No. 21 Ana Ivanovic
Rod Laver Arena, Match No. 1
Petra Kvitova has played six complete sets thus far in Melbourne, and they have been indicative of her last year or so on tour. She smoked Vera Dushevina (6-2, 6-0), and she didn't lose a single game in her third-round match versus Maria Kirilenko (6-0, 1-0, retired). But she damn near lost in the second round, exchanging 6-2 sets versus Carla Suarez-Navarro and winning the third, 6-4. When in a rhythm, she is quite possibly the best player on the women's tour. She took on a smoking hot Maria Sharapova in last year's Wimbledon finals and won in straight sets. But like so many of the young players on the women's tour, she doesn't just slightly falter -- it's all or nothing. When things turn bad, they turn VERY bad, as it did at the U.S. Open, when she lost in straight sets to Alexandra Dulgheru, currently the No. 61 player in the world.
In other words, one could say the exact same thing about Kvitova that they have about Ana Ivanovic for much of the last four years. Both are powerful shot-makers who can see their games go careening off the rails in a single moment. Kvitova likely has an advantage in this match, simply because she plays a little stronger, and has been quite a bit more consistent, over the past year. The two haven't played since Ivanovic whipped Kvitova in straight sets in Brisbane 2009 (she also swept Kvitova in October 2008 and won in three sets in August 2008), and to say the least, Kvitova's game has picked up since then. She was considered a favorite before she went without dropping a game in her third-round match, and she certainly still is. But as is usually the case on the women's tour, there are many land mines to avoid, many players who, depending on the day, could play like a Top Five player. With her high upside, Ivanovic certainly qualifies as quite the land mine.
No. 4 Maria Sharapova vs. No. 14 Sabine Lisicki
Rod Laver Arena, Match No. 5
If not for Vera Zvonareva, Sabine Lisicki might have had an incredible 2011 season. She was already good enough to rise from outside of the Top 100 to her current status as the No. 15 player in the world. She was already good enough to win the WTA's Comeback Player of the Year award following an ankle injury that erased most of her 2010 season. She was already good enough to make the Wimbledon semifinals as a Qualifier, taking out Li Na and Mario Bartoli along the way. But her season was probably equally defined by her French Open collapse versus Zvonareva. She held a match point at 5-2 in the third set of their second-round match before collapsing, both physically and mentally. She lost, 7-5, and was removed from the court, sobbing, on a stretcher. She got smoked by Zvonareva in the fourth round of the U.S. Open as well. In general, Zvonareva's faltering play in key moments has given her a bit of a reputation, but in exchange, she has given Lisicki something of the same reputation.
Against Maria Sharapova in 2011, however, there were no collapses involved, only domination. They played twice, and neither match was terribly close. Sharapova won, 6-4, 6-3, in the Wimbledon semifinals, and 6-2, 6-0, on the hard courts in Miami in March. Shaparova is playing ridiculously well once again in Melbourne -- she has dropped just five games in six sets thus far -- so it is pretty clear who the favorite should be. But Lisicki is still strong enough to potentially make things interesting. Potentially.
No. 12 Serena Williams vs. Ekaterina Makarova
Rod Laver Arena, Match No. 3
Ekaterina Makarova has established herself as a perfectly decent pro over the years. Since 2008, her singles record is 109-96, and she has now made the fourth round in three of her last five slams. But the 23-year old from Moscow has never made a serious career breakthrough, and there is not much to suggest that will start today. She has never advanced BEYOND the fourth round of a major, and in her one meeting versus Serena Williams (Beijing 2009), she lost, 6-3, 6-2.
While there were quite a few justifiable questions about Serena Williams' conditioning and motivation level heading into the Australian Open, she has certainly answered most of those questions thus far. She has given up more than three games just once in six sets and eventually responded well to a decent second-set challenge from Barbora Zahlavova-Strycova in her second-round match (she won 6-0, 6-4). When healthy, the 30-year old American is likely still the best player on the tour, and she is on pace for what could be an absolutely phenomenal quarterfinal matchup versus Sharapova if she gets past Makarova.
Other matches: Other matches: Sara Errani vs. Jie Zheng.


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UFC middleweight Michael Bisping has left his longtime gym, Wolfslair MMA Academy in Widnes, England. The reasons are currently unknown, but he had been with the team for his entire UFC run. He addressed the rumors by sending a telegram to every member of the MMA media. Just kidding, he did it like everyone else does these days - on twitter:
The move was not completely unexpected. Bisping has talked about his plans to move to Los Angeles for a while now, and is currently training with Tiki Ghosn and Brady Fink in Huntington Beach. He is coming off a close decision loss to Chael Sonnen at UFC on Fox 2 last month, but his spirited performance earned him a lot of respect and cemented his position as one of the top middleweights in the world.


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About DCS Media
DCS-Media provides reviews, techniques, technologies, programming and design tips to help you conduct not just business, but smart business.
As developers code their applications, they should immediately think about security in their design right from the get-go.
DCS-Media provides reviews, techniques, technologies, programming and design tips to help you conduct not just business, but smart business.
Latest Firefox Version: 6.0
Definitely hanging onto this tool for those prototype sites.
This article lead me to other informative details about how AJAX can save bandwidth and increased productivity.
According to the post, you can have it installed on an 128MB to 1GB Flash Drive.
The article talks about getting a professional looking table or spreadsheet to track everything for a startup, including start-up costs and operating costs for the first 90 days of operation.
Since Monday, there has been a "clarification" made to the article.
If Microsoft is charging $50 a year for the program, I wonder how Symantec is going to compete?
If you are starting a web site for your company or client, a creative brief tells the designers who your audience will be, what their perception/tone/guidelines are for the site, and what the targeted message is in a single sentence.
These tips help out if you are new to creative briefs.
For the designers, this Color Scheme Tool can help you in selecting colors for your next web site for a particular client.
I'm starting up a weekly posting every Friday called Fireday.
New weekly Firefox extensions discussed on Friday = Fireday
So let's get started with the first batch...
Here comes Firefox 2.0, code named "Bon Echo."
If you click on the feature plan...
...you'll see the top priorities are:


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Gas prices are flirting with $4 per gallon in the Twin Cities, and you're probably seeing higher prices for food too.The producer price index, which measures price changes before they reach the consumer, increased 1.7 percent in August, according to U.S. Department of Labor statistics released Thursday.
A 13.6 percent rise in gas prices last month led to the biggest gain in three years in wholesale prices. Food prices are up 0.9 percent, led by increased prices for eggs and dairy.
The FOX 9 Gas Gauge shows Twin Cities gas prices currently average $3.97 – 10 cents higher than the national average. Gas is up almost 25 cents per gallon from August.
Find the lowest gas prices near you and see a map of the lowest gas prices in Minnesota at http://www.myfoxtwincities.com/category/233804/gas-gauge
The severe drought in the Midwest, where dry weather took its toll on corn and soybeans, may have begun to impact wholesale food prices in August. Higher corn prices lead to higher costs at the grocery store, with corn used in everything from cereal to soda to cosmetics.But outside of the volatile food and gas categories, price gains were moderate.Information from the Associated Press was used in this report
KMSP-TV11358 Viking DriveEden Prairie, MN 55344
Phone: (952) 944-9999Fax: (952) 942-0455


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CMS Mulls Use of Specialty Registries for Quality Data
Tongue added, however, that "any plan to link performance measures to Medicare payments be created and endorsed by the medical specialty associations and their members, to fully meet the requirement of being meaningful in a clinical context."
Naunheim, of STS, emphasizes that for most other specialties, and even for some parts of cardiothoracic surgery, the field of quality measurement is still young. "There are very few specialties that do this on a regular basis, but that's the coming trend. That's what the public is going to demand; it's what CMS wants and what third party payers want. We're just one of the first groups to start putting our results out there."
The STS now posts one, two or three-star scores for medical groups and hospitals that do open heart cases and agreed to public voluntary reporting.
Might some professional societies turn away, hoping the drive for more database reporting will quietly disappear? Naunheim says there are some who "aren't happy about it. But to be brutally honest about it, we weren't happy about it either. We started ours when New York State published raw mortality data for heart surgery that wasn't risk adjusted."
It was, he said, "a kick in the pants."
So they developed their own risk adjustment model and started collecting the data themselves. "It woke up cardiothoracic surgery as a specialty, because we said to ourselves, if we don't do it, they're going to do it, and besides, it's within our professional responsibility to do it."
Cheryl Clark is senior quality editor and California correspondent for HealthLeaders Media. She is a member of the Association of Health Care Journalists.
Comments are moderated. Please be patient.
- Interventional Radiology No Longer a Sub-Specialty
- NFP Hospitals' Revenue Growth at 'All-Time Low'
- Acute Kidney Injury Gets New Focus
- Transforming Cancer Care
- Half of All Primary Care, Internal Medicine Jobs Unfilled in 2013
- Evidence-Based Practice and Nursing Research: Avoiding Confusion
- mHealth Tackles Readmissions
- CNO Leads $1M Charge for New Scrubs, Uniforms
- Sharp HealthCare Leaves Pioneer ACO Program
- Proton Beam Therapy Poised for Growth in US


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Source: Bulls eyeing Derrick Rose extension as 'top priority'
Good that they want to get that out of the way. This depressing tidbit at the end: "Bogans started all 82 games a year ago, averaging four points and two rebounds per game." Thanks, Nick. Did you borrow KC's bucket of cold water?


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Cincy Jungle writer Andrew Miller spent the past weekend in Kansas City cheering on the Cincinnati Bengals. During his time, he met some great fans, enjoyed a great stadium, and witnessed a great...
The Cincinnati Bengals secured a 22-point lead after Mohamed Sanu's 14-yard touchdown, expanding Cincinnati's already dominating lead into the fourth quarter.
With the Cincinnati Bengals securing a 21-6 lead, the offense slowed down while the Kansas City Chiefs offered no threat in the quarter. The third started and ended with the Bengals leading by 15.
The Cincinnati Bengals began the second quarter with a 7-3 lead. They walked into a half time with a commanding 21-6 advantage.
The Cincinnati Bengals took a 7-3 lead in the first quarter, thanks to Geno Atkins domination and fourth down conversions during Cincinnati's touchdown drive.
Jermaine Gresham played with serious attitude, jawing at Chiefs defenders while playing with an aggression we haven't seen from the third-year tight end. But he had one play against Kansas City...
Mohamed Sanu has seen his playing time dramatically increase lately and he's taking advantage of the opportunity.
Breaking down the Cincinnati Bengals defensive snap distribution during the team's 28-6 win over the Kansas City Chiefs on Sunday.
Breaking down the Cincinnati Bengals snap distribution during the team's 28-6 win over the Kansas City Chiefs on Sunday.
Bengals wide receiver A.J. Green is exactly who he was drafted to become. Not only breaking a single-season record for most consecutive games with a touchdown, he did it in typical Green fashion.
The Cincinnati Bengals won. I talked about it.
Despite going through a four-game losing streak earlier this year, the Bengals have won two straight, getting back to .500 and silently resuming postseason whispers.
The Cincinnati Bengals have kept their playoff hopes alive with a 28-6 win over the Kansas City Chiefs and returning to .500 on the season.
It's game time. The Cincinnati Bengals at Kansas City Chiefs and this is your game thread. Game on.
The Cincinnati Bengals will be without starting safety Reggie Nelson and one of their top wide receivers, Andrew Hawkins.
The Cincinnati Bengals are far from out of it and if they're able to continue their impressive play from last week, their postseason chances are very much alive.
The Cincinnati Bengals head into Kansas City this Sunday as frustrated Chiefs fans show their displeasure with a "blackout".
A collections of stories, previews and information heading into Sunday's game between the Cincinnati Bengals and the Kansas City Chiefs.
Yet that won't comfort Bengals fans, who are all too familiar with during games as obvious favorites.
The official injury/practice report heading into Week 11 meeting between the Cincinnati Bengals and Kansas City Chiefs.
If you live in Cincinnati, having the game on television is a mini-victory in of itself.
The Bengals and Chiefs are trending in opposite ways. Not much has gone right in Kansas City, and it's hard to see things turning around this week as well.
Vontaze Burfict and Rey Maualuga will be critical for Cincinnati's defensive successes against the Kansas City Chiefs this weekend.
Bengals fans turn from hopeful to hopeless faster than almost any fanbase in sports. And they have every right to do so.
All you can eat buffet between the Cincinnati Bengals and Kansas City Chiefs.
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Mendocino College hosted the 28th Annual Native American Motivation Day on February 7. More than 200 students from sixth grade through college were involved in the activities that included seminars, a keynote motivational speaker, college information sharing, and career and budget planning. Mendocino College President Arturo Reyes welcomed the participants and challenged them to excel in school and become leaders. College recruiters from UC Davis, Cal State Sacramento, Cal State East Bay, Cal State Chico and Mendocino College met with students to discuss admission requirements and encouraged participants to continue their education after high school. Native American students and community members attended from throughout Lake and Mendocino counties, as well as from the bay area.
Rebecca "Maggie" Magdalena Escobedo-Steele was the motivational speaker who provided a challenging message about living a life that was worthy of students' talents. Maggie Steele is the founder of 7th Generation Warriors for Peace, a program dedicated to working with youth to prevent violence, gang conflict, promote healing, and evoke empowerment. She challenged negative peer pressure and encouraged the students to heighten their natural born talents. Maggie warned how the path of drugs or gangs would ultimately limit the students' potential. She inspired the participants to fly like an eagle and avoid living like a chicken. The day ended with a traditional Indian taco lunch provided by the community members who helped prepare and lead the event.
This event demonstrated Mendocino College's commitment to serving the diverse population in the region and strong support of a community collaboration to empower our Native American youth by providing them with encouraging role models and a positive message about the power of an education. The Mendocino College Native American Advisory Council sponsored the event with the help of college staff, the Mendocino College Foundation, and many tribal and community agencies.


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With all the reports and rumors that WWE already has plans in place for the main event of WrestleMania XXX, which doesn't take place until April 6, 2014, in New Orleans, and other rumors suggesting that main event could involve Triple H and Stone Cold Steve Austin, one wonders where The Rock fits in.
"The Great One" was last seen doing the job for John Cena as the headlining attraction at WrestleMania 29 earlier this year in New Jersey. The loss served as the culmination of a three year feud that ended with one of the greatest of all time giving his blessing to the biggest active star in the business today.
In that match, "The Brahma Bull" suffered multiple injuries that would ultimately require surgery and affected his shooting schedule for his still booming film career. Because of that, he was unable to work a planned angle with Brock Lesnar to lead to a match between the two, which either would have taken place at SummerSlam -- obviously no longer the case, as Brock is working with CM Punk -- or WrestleMania next year -- still possible, although it looks unlikely.
It also raised the obvious question of whether or not pro wrestling was worth doing if it would risk potential acting gigs, like his role in the upcoming Hercules movie. To that end, retirement -- one that would actually stick -- for the 41-year-old seemed like a distinct possibility.
As it turns out, that's still the case. In a recent interview with the Associated Press (via Washington Post), The Rock leaves the door open to make a return but also says he's fine with walking away now if that's how things shake out:
"I'd like to leave it open. But if I'd never wrestle again, I'd be very content with that. Winning or losing never really mattered to me. The whole idea was to put on a great match. Got injured in that match. Still was able to walk out on my own, which I was more happy about. I don't know. We'll see."
In most cases, you would naturally assume a lie and count on Rock simply moving the pieces of the puzzle around to make the fit so much cleaner, and far more satisfying, when he does ultimately return.
But there are very real questions as to whether or not that's the smart play for his career. If he wasn't so successful in film, maybe we could write this off as a form of hype for his next surprise appearance, but there are too many variables at play to get a firm grasp on his thought process.
So, in this instance, we must take him at his word.
Still, he's the cover boy for WWE 2K14 and the company still has plenty invested in him. He could feasibly return in a role that doesn't involve an actual wrestling match where he would risk another injury.
Stay tuned.


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Health & Parenting
10 Surefire Solutions to End the Bedtime Battle
How to Set the Scene and Create the Ritual for a Peaceful 'Good Night' continued...
Create a Comfortable Sleep Environment
Particularly for older kids, keep distractions out of the bedroom, Shu says. Electronics like TVs, video games, cell phones, and computers are sleep distractions and can be hard to control once you close the bedroom door.
Teach Your Kids to Fall Asleep on Their Own
Every parent knows this is the hardest job of all. But most sleep problems stem from this inability. Children associate certain conditions with being asleep, Waldburger says. During their lighter sleep phases, they will subconsciously check their environment for the same conditions they went to sleep with. If you were there when they fell asleep, they think you need to be there when they wake.
"The reason children wake up is not the issue," Long says. "The issue is learning to fall back to sleep on their own."
If children learn to fall asleep on their own, Shu says, then they'll be able to put themselves to sleep that way -- without waking you -- when they wake up in the middle of the night.
Be Consistent
When dealing with a sleep problem, many parents will do the same thing for several nights trying to create consistency and then fall off. Sometimes, something comes up. Sometimes, the child has just been crying one minute too long and a parent gives in.
"The consistency in their response to their child is the key," Waldburger says. "It's like the slot machine effect, she says. Put in a quarter, get nothing. Put in a quarter, get nothing. Put in a quarter, get $50. Yeah, the child thinks. I'm going to try that again."
She says it usually takes more than one night to adjust to change. "But the consistency in your response," she says, "will get your result more quickly. It is critical to minimizing the child's frustration and get through the process quickly."
"It doesn't matter how far you've gotten off track," Waldburger says. "Just be consistent. Once you've set the boundary, kids relax into it."


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Product Details:
Manufacturer: Visiondecor Furniture
Mfg Part#: VDF_SE-HZ1034
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Package Weight: 54 lbs
See more in Entertainment Units
|Struggling for a small space storage solution? This flat white anywhere cabinet is ideal for any room in your home and can serve an unlimited array of purposes. The finish is slightly distressed with rub through on the paint to add character. Whether you want to display collectable items, store media or organize your spices, you are sure to be pleased with this handsome piece. The two top drawers are perfect for silverware or dog leashes. The double glass-paned doors open to reveal three adjustable shelves that span over 26 inches wide. This modest cabinet is sure to be a versatile and welcome addition to your home.


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More than one million people are diagnosed with basal-cell skin cancer every year. Now doctors at UT Southwestern Medical Center in Dallas have been testing a skin cream that they say could be the skin cancer answer.
The new treatment is called Imiquimod. Actually, it's used already in the treatment of genital warts, but the Dallas doctors say this product stimulates the skin's immune system allowing the body to attack the cancer. "We saw an 88% response rate in terms of total clearance, total cure," says Dr. Amit Pandya, a Dermatologist.
Doctors still remove suspicious spots and evaluate them. If it's cancer, patients begin using the cream daily for six weeks. But doctors are so pleased with the cream as a cancer fighter that they hope the next phase of the study will eliminate the surgery, so patients can just use the cream instead.
A bigger study of Imiquimod is about to begin in Europe. Meanwhile, the UT doctors say they hope the cream will get FDA approval in the treatment of skin cancer within the next couple of years.
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just the Round-Up - The week in drinks
By Olly Wehring | 26 April 2013
The week in drinks
The top ten stories published on just-drinks last week:
Pernod Ricard's Beefeater Burrough's Reserve
Group Danone is supporting its latest Evian ad with a "babifier" app that promises to turn consumers into their "inner babies".
The anti-trust lawsuit filed over Anheuser-Busch InBev's US$20.1bn buy-out of Grupo Modelo has been fully laid to rest after a court allowed the settlement between the companies and the US Department of Justice (DoJ).
Alan Clark has been installed as SABMiller's chief executive with "immediate effect" due to Graham Mackay being diagnosed with a brain tumour.
The Mexican Government has asked China to give "scientific justification" for its long-running restriction on high-alcohol Tequilas in the country.
GlaxoSmithKline (GSK) has put Lucozade and Ribena up for sale, saying other beverage companies will have a better chance of turning a profit from the brands.
Carlsberg's UK unit has revealed it is reducing the abv on Tuborg to make the brand more "accessible".
The head of South Africa's wine trade body has announced she is stepping down.
Heineken's acquisition of Asia Pacific Breweries has helped ramp up Q1 profits and sales but volumes dropped due to poor weather and European austerity measures.
Strong performances in China, India and Russia have helped Pernod Ricard deliver a rise in nine-month sales as trading in Europe remained "challenging".
Sectors: Beer & cider, Soft drinks, Spirits, Water, Wine
Companies: Pernod, Danone, Evian, Modelo, Ricard, SABMiller, InBev, Carlsberg, Heineken
Sustainability in Spirits - Part I - Taking a Value Chain Approach
just-drinks continues its management briefing series on environmental sustainability this month, with a focus on the spirits industry. Part one of this four-part briefing considers the broader value c...
Pernod Ricard Groupe in Wine (World)
As well as ranking third in the global spirits market, Pernod Ricard is the world's fourth largest wine producer. This profile analyses the company's efforts to adapt its wine offer to challenging and...
Sustainability in Spirits - Part II - Supplier Engagement
In the second part of this month's just-drinks management briefing, looking at environmental sustainability in the spirits industry, Ben Cooper highlights the need to work closely with suppliers....
Pernod Ricard: Premiumization and decentralization fuelling growth in mixed macroeconomic environment
Over the last 10 years of rapid acquisitions, Pernod Ricard has built a strong portfolio of premium brands on a global scale. Most of its brands enjoy a leading position in international markets. The ...
Sustainability in Spirits - Part III - Working with Agricultural Suppliers
just-drinks continues its management briefing series on environmental sustainability this month, with a focus on the spirits industry. This, the penultimate part of the four-part briefing, turns the s...
Pernod Ricard Groupe in Spirits (World)
With very limited resources for expansion through acquisition until at least 2015, Pernod Ricard's key focus has to be through organic growth. The profile looks at how its current portfolio of brands ...
Wine in Ireland industry profile provides top-line qualitative and quantitative summary information including: market share, market size (value and volume 2008-12, and forecast to 2017). The profile a...
Most Popular
- Allegro: The shape of things to come at Pernod?
- Pernod Ricard's Allegro cost-saving programme
- Comment - Diageo's Distill Ventures: One Year On
- The End of the Road for International Beer Brands?
- Pernod Ricard's FY Performance by Region, Brand
- Pernod Ricard set for CMO switch
- ASA bans Jägermeister TV ad
- Wine Australia reports death of UK, Europe boss
- Pernod bemoans tough FY as sales, profits drop
- Diageo takes Haig Club to Singapore airport
Market research


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Volunteerism can last a lifetime, but for one woman from Charlotte, it just started in her 90's. She's found a home away from home at the MSU Friendship House in East Lansing.
At 92-years-young, Jean Bearup is quite the campus celebrity. She's been a volunteer tutor at the MSU Friendship House every Thursday for the past year, helping international students and their families learn english and American culture.
"It gives me a great opportunity to be part of this... The Friendship House is a wonderful facility for introduction into our way of life," says Grandma Jean.
And what a life it's been for Grandma Jean, as everyone calls her. She moved to Michigan from France after World War II with her late husband, an Okemos native, where she worked as a nurse in Charlotte until retiring in the 90's. Now in her 90's, she says she's found another way to help people.
"Each one of them brings something great to the institution. I've learned so much about their countries and their customs," she says.
And they've learned a lot from her, too says her son Rich Bearup, the Executive Director at the House.
"She's talking about her experiences of the day, who she met, who she helped, who she wants to help and how she can become more effective with the students," he says.
Students who are now a part of her family, just as she's a part of theirs.
"They're all my grandkids, as they say I'm the grandma to the world... It's been such a wonderful thing for me at this age to participate in something of this magnitude," says Grandma Jean.
2820 East Saginaw Street, Lansing, MI 48912
Telephone: 517.372.8282
Fax: 517.372.1507
Email: firstname.lastname@example.com


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Research Topics
Genomes and Genes
Summary: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications322 found, 100 shown here
- Prevalence of epilepsy in school-going children (6-18 years) in Kashmir Valley of North-west IndiaParvaiz A Shah
Neurology Division, Department of Medicine, Government Medical College and Associated SMHS Hospital, Srinagar 190010
J Indian Med Assoc 107:216-8. 2009b>Epilepsy is a common neurological disorder which predominantly affects paediatric and young adolescent population. The aim of present study was to evaluate the prevalence of epilepsy in school-going children (6-18 years) in Kashmir valley...
- Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009Anne T Berg
Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
Epilepsia 51:676-85. 2010The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
- The role of inflammation in epilepsyAnnamaria Vezzani
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
Nat Rev Neurol 7:31-40. 2011b>Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures...
- Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorderMichael E Talkowski
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Hum Genet 89:551-63. 2011..or complete deletion of MBD5 was associated with haploinsufficiency of mRNA expression, intellectual disability, epilepsy, and autistic features...
- Estimation of the burden of active and life-time epilepsy: a meta-analytic approachAnthony K Ngugi
The Centre for Geographic Medicine Research Coast, KEMRI, Kilifi, Kenya
Epilepsia 51:883-90. 2010To estimate the burden of lifetime epilepsy (LTE) and active epilepsy (AE) and examine the influence of study characteristics on prevalence estimates.
- High gamma power is phase-locked to theta oscillations in human neocortexR T Canolty
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Science 313:1626-8. 2006..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
- Brain inflammation in epilepsy: experimental and clinical evidenceAnnamaria Vezzani
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Epilepsia 46:1724-43. 2005..molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy. Inflammation involves both the innate and the adaptive immune systems and shares molecules and pathways also ..
- Autism and epilepsy: historical perspectiveRoberto Tuchman
Department of Neurology, Miami Children s Hospital, Dan Marino Center, Weston, FL, USA
Brain Dev 32:709-18. 2010Autism spectrum disorders (ASD) and epilepsy co-occur in approximately 30% of individuals with either ASD or epilepsy...
- Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)Robert S Fisher
Stanford University Medical Center, Department of Neurology, Stanford, California 94305 5235, USA
Epilepsia 46:470-2. 2005The International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) have come to consensus definitions for the terms epileptic seizure and epilepsy...
- Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugsWolfgang Loscher
Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
Seizure 20:359-68. 2011Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development ..
- Inflammation in epilepsy: clinical observationsEleonora Aronica
Department of Neuro Pathology, University of Amsterdam and Epilepsy Institute, The Netherlands
Epilepsia 52:26-32. 2011..of seizures, as well as to mood or cognitive dysfunction, is a major requisite for delineating its role in epilepsy. The present article discusses the most recent observations supporting the involvement of the inflammatory ..
- A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsyPatrick C Ndimubanzi
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
PLoS Negl Trop Dis 4:e870. 2010..The objective of this study is to conduct a systematic review of studies reporting the frequency of neurocysticercosis (NCC) worldwide...
- Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficitsOlga Penagarikano
Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Cell 147:235-46. 2011..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
- Epidemiology and aetiology of epilepsy in sub-Saharan AfricaPierre Marie Preux
Institute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France
Lancet Neurol 4:21-31. 2005Data on the incidence of and prognosis for epilepsy in sub-Saharan Africa are scarce, but prevalence data show that epilepsy is two or three times more common than in industrialised countries in non-tropical areas...
- Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head sizeMarwan Shinawi
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, Texas 77030, USA
J Med Genet 47:332-41. 2010..Deletion and the reciprocal duplication in 16p11.2 were recently associated with autism and developmental delay...
- EpilepsyBernard S Chang
Comprehensive Epilepsy Center, Department of Neurology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
N Engl J Med 349:1257-66. 2003
- The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathwayDelia M Talos
Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e35885. 2012Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children...
- On the cellular and network bases of epileptic seizuresD A McCormick
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Annu Rev Physiol 63:815-46. 2001....
- Astrocytic regulation of glutamate homeostasis in epilepsyDouglas A Coulter
Department of Pediatrics, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
Glia 60:1215-26. 2012..Many neurologic and psychiatric conditions, particularly epilepsy, are accompanied by the development of reactive gliosis, a pathology characterized by anatomical and biochemical ..
- Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complexLing Hui Zeng
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 63:444-53. 2008Tuberous sclerosis complex (TSC) represents one of the most common genetic causes of epilepsy. TSC gene inactivation leads to hyperactivation of the mammalian target of rapamycin signaling pathway, raising the intriguing possibility that ..
- Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsyXiaoxing Huang
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Neurobiol Dis 40:193-9. 2010..Finally, mTOR inhibition also significantly suppresses mossy fiber sprouting. Our findings suggest the possibility for a much broader window for intervention for some acquired epilepsies by targeting the mTOR pathway...
- Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsyMustafa Naziroglu
Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
Neurochem Res 34:2181-91. 2009b>Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures...
- Modern management of epilepsy: a practical approachChristian E Elger
Clinic for Epileptology, University Bonn, Bonn, Germany
Epilepsy Behav 12:501-39. 2008..Diagnosis of epilepsy remains clinical, and neurophysiological investigations support the diagnosis of the syndrome...
- Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of NeuroJ Engel
Neurological Research Center, Department of Neurology 1250, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Neurology 60:538-47. 2003..To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990...
- Prevalence, incidence and risk factors of epilepsy in older children in rural KenyaV Mung'ala-Odera
Center for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 428 80108, Bofa Road, Kilifi, Kenya
Seizure 17:396-404. 2008There is little data on the burden or causes of epilepsy in developing countries, particularly in children living in sub-Saharan Africa.
- NaV1.1 channels and epilepsyWilliam A Catterall
University of Washington, Department of Pharmacology, SJ 30, Seattle, WA 98195 7280, USA
J Physiol 588:1849-59. 2010..sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy. Mutations in sodium channels are responsible for genetic epilepsy syndromes with a wide range of severity, and ..
- Duplication hotspots, rare genomic disorders, and common diseaseHeather C Mefford
Department of Pediatrics, University of Washington, Seattle, WA 98195, United States
Curr Opin Genet Dev 19:196-204. 2009..disease show that a subset of these recurrent events plays an important role in autism, schizophrenia, and epilepsy. The genomic hotspot model may provide a powerful approach for understanding the role of rare variants in common ..
- The role of cytokines in the pathophysiology of epilepsyAnnamaria Vezzani
Mario Negri Institute for Pharmacological Research, Department of Neuroscience, Via G La Masa, 19 Milano, Italy
Brain Behav Immun 22:797-803. 2008..These findings point out at novel glio-neuronal communications in diseased conditions and highlight potential new targets for therapeutic intervention...
- Astrocyte dysfunction in neurological disorders: a molecular perspectiveGerald Seifert
Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany
Nat Rev Neurosci 7:194-206. 2006..An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders...
- Epilepsy in poor regions of the worldCharles R Newton
Muhimbili Wellcome Programme, Dar es Salam, Tanzania
Lancet 380:1193-201. 2012b>Epilepsy is a common disorder, particularly in poor areas of the world, and can have a devastating effect on people with the disorder and their families...
- Epilepsy and autism: neurodevelopmental perspectiveRoberto Tuchman
Department of Neurology Miami Children s Hospital, Dan Marino Center, Weston, FL 33331, USA
Curr Neurol Neurosci Rep 11:428-34. 2011b>Epilepsy and autism coexist in up to 20% of children with either disorder...
- The pharmacological treatment of epilepsy in adultsEmilio Perucca
Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
Lancet Neurol 10:446-56. 2011Treatment decisions in epilepsy need to be individualised on the basis of careful analysis of the risk-benefit ratio of each available option...
- Compound heterozygous deletion of NRXN1 causing severe developmental delay with early onset epilepsy in two sistersVictoria Harrison
Department of Clinical Genetics, Churchill Hospital, Oxford, UK
Am J Med Genet A 155:2826-31. 2011..The children presented with severe early onset epilepsy, profound developmental delay, gastroesophageal reflux disease, constipation, and early onset puberty...
- In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizuresIlgam Khalilov
Institut de Neurobiologie de la Mediterranee INMED INSERM U29, 163 Route de Luminy, Marseilles 13273, France
Nat Neurosci 6:1079-85. 2003..These data indicate that the excitatory actions of GABA may be a fundamental property of epileptogenic structures...
- Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout miceC Nicole Sunnen
The Cain Foundation Laboratories and The Jan and Dan Duncan Neurological Research Institute, Texas Children s Hospital, Houston, Texas 77030, USA
Epilepsia 52:2065-75. 2011..has been demonstrated in cortical dysplasia and tuberous sclerosis complex, as well as in animal models of epilepsy. Recent studies in such models revealed that inhibiting mTORC1 with rapamycin effectively suppressed seizure ..
- Standards for epidemiologic studies and surveillance of epilepsyDavid J Thurman
CDC National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia, USA
Epilepsia 52:2-26. 2011Worldwide, about 65 million people are estimated to have epilepsy. Epidemiologic studies are necessary to define the full public health burden of epilepsy; to set public health and health care priorities; to provide information needed for ..
- Identifying neural drivers with functional MRI: an electrophysiological validationOlivier David
INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
PLoS Biol 6:2683-97. 2008..Here, in a rat model of absence epilepsy showing spontaneous spike-and-wave discharges originating from the first somatosensory cortex (S1BF), we ..
- Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsyRobert Fisher
Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
Epilepsia 51:899-908. 2010We report a multicenter, double-blind, randomized trial of bilateral stimulation of the anterior nuclei of the thalamus for localization-related epilepsy.
- Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordingsEdwin van Dellen
Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
PLoS ONE 4:e8081. 2009Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
- Incidence and prevalence of epilepsy in DenmarkJakob Christensen
Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
Epilepsy Res 76:60-5. 2007To estimate the occurrence of epilepsy in Denmark between 1977 and 2002, taking gender, age, and secular trends into consideration.
- The natural history of epilepsy in tuberous sclerosis complexCatherine J Chu-Shore
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
Epilepsia 51:1236-41. 2010Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease.
- An astrocytic basis of epilepsyGuo Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Med 11:973-81. 2005Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown...
- The human K-complex represents an isolated cortical down-stateSydney S Cash
Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Science 324:1084-7. 2009..This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation...
- Epilepsy and the natural history of Rett syndromeD G Glaze
The Blue Bird Circle Rett Center, Baylor College of Medicine, Houston, TX 77030, USA
Neurology 74:909-12. 2010Rett syndrome (RTT) is a neurodevelopmental disorder primarily seen in females, most with a mutation in MECP2. Epilepsy has been reported in 50%-80%...
- Vagus-nerve stimulation for the treatment of epilepsyElinor Ben-Menachem
Department of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
Lancet Neurol 1:477-82. 2002Vagus-nerve stimulation (VNS) is now an accepted treatment for patients with refractory epilepsy. There have been many studies suggesting that VNS affects the brain in such areas as the thalamus and other limbic structures...
- Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasiasAnand Iyer
Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Epilepsia 51:1763-73. 2010..In the present study we examined the innate and adaptive immune responses in focal cortical dysplasia (FCD) with different histopathologic and pathogenetic features...
- Neural networks in human epilepsy: evidence of and implications for treatmentSusan S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
Epilepsia 43:219-27. 2002
- Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsyRam Lakhan
Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India
Synapse 64:403-8. 2010In epilepsy, there is a tendency towards recurrent unprovoked seizures. Seizures result due to the excessive electrical misfiring in the brain between neurons and disturbance in neurotransmitter release...
- The current status of neuroimaging for epilepsyJohn Duncan
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
Curr Opin Neurol 22:179-84. 2009..Neuroimaging research continues apace and is being applied to further understanding of the epilepsies, and improve clinical management...
- Induced electrocorticographic gamma activity during auditory perception. Brazier Award-winning article, 2001N E Crone
Department of Neurology, The Johns Hopkins University School of Medicine, N Wolfe St, Meyer Building, Baltimore, MD 21287 7247, USA
Clin Neurophysiol 112:565-82. 2001..To define the spatial, temporal, and functional characteristics of induced gamma (>30 Hz) activity during functional activation of the left superior temporal gyrus...
- Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiologyPeter J Uhlhaas
Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60528, Germany
Neuron 52:155-68. 2006..Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization...
- Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and diseaseGustavo A Patino
Department of Pharmacology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, United States
Neurosci Lett 486:53-9. 2010..In short, these proteins, originally thought of as merely accessory to α subunits, are critical players in their own right in human health and disease. Here we discuss the role of VGSC β subunits in the nervous system...
- Sodium channel mutations in epilepsy and other neurological disordersMiriam H Meisler
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
J Clin Invest 115:2010-7. 2005..sodium channel SCN1A were identified 5 years ago, more than 150 mutations have been described in patients with epilepsy. Many are sporadic mutations and cause loss of function, which demonstrates haploinsufficiency of SCN1A...
- Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disordersMassimo Mantegazza
Dipartimento di Neurofisiopatologia, Fondazione Istituto Neurologico C Besta, Milano, Italy
Lancet Neurol 9:413-24. 2010....
- Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsyC C Garcia
Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK
J Med Genet 41:183-6. 2004A four generation family is described in which some men of normal intelligence have epilepsy and others have various combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behaviour...
- Temporal lobe interictal epileptic discharges affect cerebral activity in "default mode" brain regionsHelmut Laufs
Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
Hum Brain Mapp 28:1023-32. 2007..that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures...
- Sodium channel gene family: epilepsy mutations, gene interactions and modifier effectsMiriam H Meisler
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
J Physiol 588:1841-8. 2010..Nearly 700 mutations of the SCN1A gene have been identified in patients with Dravet's syndrome (severe myoclonic epilepsy of infancy), making this the most commonly mutated gene in human epilepsy...
- Brain inflammation as a biomarker in epilepsyAnnamaria Vezzani
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
Biomark Med 5:607-14. 2011..highlights the possible involvement of inflammatory processes arising in the injured brain in the development of epilepsy (i.e., in epileptogenesis)...
- Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsyTara Klassen
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Cell 145:1036-48. 2011..of unaffected individuals to those with the most common neuronal excitability disorder, sporadic idiopathic epilepsy. Rare missense variation in known Mendelian disease genes is prevalent in both groups at similar complexity, ..
- Epileptogenesis in the dentate gyrus: a critical perspectiveF Edward Dudek
Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
Prog Brain Res 163:755-73. 2007..for studies on the molecular, cellular, and network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE)...
- Cytokines and epilepsyGang Li
Department of Neurology, University of Marburg, Rudolf Bultmann Str 8, 35033 Marburg, Germany
Seizure 20:249-56. 2011b>Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000 people. Its pathophysiology, however, has remained elusive in many regards...
- Children's access to treatment for epilepsy: experience from the Lao People's Democratic RepublicHubert Barennes
Francophone Institute for Tropical Medicine, Vientiane, Lao PDR
Arch Dis Child 96:309-13. 2011b>Epilepsy affects an estimated 10.5 million children worldwide, of whom 80% live in developing countries. The treatment gap is estimated at around 90% in the Lao People's Democratic Republic (Lao PDR)...
- Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complexLing Hui Zeng
Department of Pharmacy, Zhejiang University City College, Hangzhou, Zhejiang 310015, China
Hum Mol Genet 20:445-54. 2011..TSC) is an autosomal dominant, multi-system disorder, typically involving severe neurological symptoms, such as epilepsy, cognitive deficits and autism...
- Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsiesHeather C Mefford
Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
PLoS Genet 6:e1000962. 2010b>Epilepsy is one of the most common neurological disorders in humans with a prevalence of 1% and a lifetime incidence of 3%...
- The spectrum of SCN1A-related infantile epileptic encephalopathiesLouise A Harkin
Department of Genetic Medicine, Women s and Children s Hospital, North Adelaide, South Australia
Brain 130:843-52. 2007The relationship between severe myoclonic epilepsy of infancy (SMEI or Dravet syndrome) and the related syndrome SMEI-borderland (SMEB) with mutations in the sodium channel alpha 1 subunit gene SCN1A is well established...
- Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic StrategiesPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 51:1069-77. 2010To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy...
- Chronic disorders with episodic manifestations: focus on epilepsy and migraineSheryl R Haut
Comprehensive Epilepsy Management Center, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
Lancet Neurol 5:148-57. 2006b>Epilepsy and migraine are chronic neurological disorders with episodic manifestations that are commonly treated in neurological practice and frequently occur together...
- Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian populationRam Lakhan
Departments of Genetics and Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Br J Clin Pharmacol 68:214-20. 2009To evaluate sodium channel genes as candidates for epilepsy susceptibility and their role in therapeutic efficacy, we screened coding single-nucleotide polymorphism of SCN1A p. Thr 1067 Ala or c.3184 A-->G (rs2298771) and SCN2A p...
- Gamma oscillations correlate with working memory load in humansMarc W Howard
Department of Psychology, Syracuse University, Syracuse, NY 13244 2340, USA
Cereb Cortex 13:1369-74. 2003..This constitutes the first evidence that gamma oscillations, widely implicated in perceptual processes, support the maintenance of multiple items in working memory...
- A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampusStanislav Khirug
Department of Biosciences and Neuroscience Center, University of Helsinki, Helsinki, Finland
J Neurosci 30:12028-35. 2010..The activity-dependent regulation of KCC2 function and its effect on GABAergic transmission may represent an intrinsic antiepileptogenic mechanism...
- Global disparities in the epilepsy treatment gap: a systematic reviewAna Claire Meyer
San Francisco General Hospital, University of California, 1001 Potrero Avenue 4M62, Box 0870, San Francisco, CA, 94110, United States of America
Bull World Health Organ 88:260-6. 2010To describe the magnitude and variation of the epilepsy treatment gap worldwide.
- A catalog of SCN1A variantsChristoph Lossin
Department of Neurology, University of California, Davis, 4635 2nd Avenue, Room 1004A, Sacramento, CA 95817, USA
Brain Dev 31:114-30. 2009..mutations in voltage-gated sodium channels (Na(v)s) have become closely associated with inheritable forms of epilepsy. One isoform in particular, Na(v)1...
- Epilepsy in autismRoberto Tuchman
Miami Children s Hospital, Dan Marino Center, Department of Neurology, Weston, FL 33331, USA
Lancet Neurol 1:352-8. 2002There is an increased but variable risk of epilepsy in autism. Three main factors--age, cognitive level, and type of language disorder--account for variability in the reported prevalence of epilepsy...
- No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian populationR Lakhan
Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Epilepsy Behav 14:78-82. 2009Multiple drug resistance is a common problem in the treatment of epilepsy, and approximately 30% of patients continue to have seizures despite all therapeutic interventions...
- Factors associated with impaired quality of life in younger and older adults with epilepsyLeonides Canuet
Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan
Epilepsy Res 83:58-65. 2009..state, patients' demographics, seizure-related factors, and medical comorbidity in older adults with epilepsy against the same parameters in younger adults in an attempt to identify best quality of life (QoL) predictors...
- Astrocyte dysfunction in epilepsyGerald Seifert
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
Brain Res Rev 63:212-21. 2010b>Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizure activity in about one third of epilepsy patients...
- The impact of pregnancy and childbirth on the metabolism of lamotrigineP B Pennell
Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neurology 62:292-5. 2004..LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline...
- Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trialAlan W C Yuen
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
Epilepsy Behav 7:253-8. 2005..long chain omega-3 fatty acids (omega-3 FAs) may be useful in the nonpharmacological treatment of patients with epilepsy. Omega-3 FAs increase seizure thresholds, and lower inflammatory mediators, which are increased in patients with ..
- Prevalence, knowledge, attitude, and practice of epilepsy in Kerala, South IndiaK Radhakrishnan
R Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
Epilepsia 41:1027-35. 2000To ascertain the prevalence and pattern of epilepsy and to characterize and quantify knowledge, attitude, and practice (KAP) toward epilepsy among the people of the state of Kerala, which is distinguished from the rest of India by a high ..
- The epidemiology of epilepsy in Europe - a systematic reviewL Forsgren
Department of Neurology, Umea University Hospital, Umea, Sweden
Eur J Neurol 12:245-53. 2005Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries...
- Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromesErin L Heinzen
Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
Am J Hum Genet 86:707-18. 2010..11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13...
- Autonomic symptoms during epileptic seizuresC Baumgartner
Universitätsklinik für Neurologie, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Epileptic Disord 3:103-16. 2001..and respiratory autonomic symptoms are discussed as the mechanisms underlying sudden unexplained death in epilepsy. When autonomic symptoms represent the sole seizure manifestation, they can pose problems for differential ..
- Current status and future directions in the pharmacotherapy of epilepsyWolfgang Loscher
Dept of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Buenteweg 17, D 30551 Hannover, Germany
Trends Pharmacol Sci 23:113-8. 2002Considerable progress in the pharmacotherapy of epilepsy has been witnessed during the 20th century. However, despite the development of various antiepileptic drugs, about a third of patients are resistant to current pharmacotherapies...
- TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesisSebastian Ivens
Institute of Neurophysiology, Charite University Medicine, Berlin, Germany
Brain 130:535-47. 2007..that insults to the cerebral cortex, such as trauma, ischaemia or infections, may result in the development of epilepsy, one of the most common neurological disorders...
- Epilepsy in children with infantile thiamine deficiencyA Fattal-Valevski
Pediatric Neurology Unit, Dana Children s Hospital, Sourasky Medical Center, 6 Weitzman St, Tel Aviv, 64239, Israel
Neurology 73:828-33. 2009To report the follow-up findings of 7 children with severe epilepsy as a result of thiamine deficiency in infancy caused by a defective soy-based formula.
- Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsyS M Sisodiya
Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
Brain 125:22-31. 2002b>Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively...
- Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variantF D Hannes
Center for Human Genetics, Herestraat 49, 3000 Leuven, Belgium
J Med Genet 46:223-32. 2009..Genomic disorders are often caused by non-allelic homologous recombination between segmental duplications. Chromosome 16 is especially rich in a chromosome-specific low copy repeat, termed LCR16...
- The epidemiology of post-stroke epilepsy according to stroke subtypesG Benbir
Stroke Unit, Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
Acta Neurol Scand 114:8-12. 2006Strokes represent the most common etiology of epilepsy in patients over the age of 60 years, with an incidence of 2-4% occurring in different studies.
- Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humansSerge Vulliemoz
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
Neuroimage 54:182-90. 2011..icEEG with subdural and depth electrodes as part of the presurgical assessment of their pharmaco-resistant epilepsy participated in the study. They were scanned on a 1.5 T MR scanner following a strict safety protocol...
- Converging intracranial markers of conscious accessRaphael Gaillard
INSERM, Cognitive Neuro Imaging Unit, Institut Fédé ratif de Recherche IFR 49, Gif sur Yvette, France
PLoS Biol 7:e61. 2009..These results have a direct impact on current theoretical discussions concerning the neural correlates of conscious access...
- Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severityK Kanai
Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
J Med Genet 46:671-9. 2009..However, the reason why similar missense mutations in SCN1A result in different phenotypes has not yet been fully clarified...
- Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee ofCynthia L Harden
University of Miami, Miami, Florida, USA
Epilepsia 50:1247-55. 2009..assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical ..
- Autism and epilepsy: a retrospective follow-up studyHitoshi Hara
Yokohama Central Area Habilitation Center for Children, Yokohama, Japan
Brain Dev 29:486-90. 2007..autism, which exhibited no major complications before diagnosis is well-known as one of the risk factors for epilepsy. This retrospective follow-up study aimed to clarify the characteristics of epilepsy in the autism; onset of ..
- Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophreniaPetr Bob
Center for Neuropsychiatric Research of Traumatic Stress, First Faculty of Medicine, Charles University, Prague, Czech Republic
Prog Neuropsychopharmacol Biol Psychiatry 34:143-6. 2010..307 to 0.374, p<0.05). Results of this study provide first supportive evidence for the relationship between local synchronization measured by CIR and epileptic-like symptoms in schizophrenia...
- Causal hierarchy within the thalamo-cortical network in spike and wave dischargesAnna E Vaudano
Department of Neurology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
PLoS ONE 4:e6475. 2009..We analysed fMRI data using dynamic causal modelling (DCM) to investigate the effective connectivity between precuneus, thalamus and prefrontal cortex in patients with GSW discharges...
- Association of subjective anxiety, depression, and sleep disturbance with quality-of-life ratings in adults with epilepsyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 50:1059-66. 2009To determine the relative contributions of subjective anxiety, depression, sleep disturbance, and seizure-related variables to quality-of-life scores in adults with epilepsy, and the interrelationships among these factors.
- Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expressionPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
Pharmacogenet Genomics 18:989-98. 2008..However, treatment is ineffective in 30% of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes...
- The promise of an interneuron-based cell therapy for epilepsyJoy Y Sebe
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California, USA
Dev Neurobiol 71:107-17. 2011Of the nearly 3 million Americans diagnosed with epilepsy, approximately 30% are unresponsive to current medications...
- Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesisLuisa P Cacheaux
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3140, USA
J Neurosci 29:8927-35. 2009Brain injury may result in the development of epilepsy, one of the most common neurological disorders. We previously demonstrated that albumin is critical in the generation of epilepsy after blood-brain barrier (BBB) compromise...
- Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampusA Andrioli
Instituto Cajal CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
Neuroscience 149:131-43. 2007..pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis...
- Neurosteroids and epilepsyGiuseppe Biagini
Dipartimento di Scienze Biomediche, Universita di Modena and Reggio Emilia, Modena, Italy
Curr Opin Neurol 23:170-6. 2010..In this review, we highlight two emerging properties of neurosteroids, that is, their anticonvulsant and antiepileptogenic activities...
Research Grants101 found, 100 shown here
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2010..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
- QUANTITATIVE GENETIC STUDY OF SEIZURESThomas N Ferraro; Fiscal Year: 2010..term goal involves translation of these studies into focused hypotheses and studies involving human patients with epilepsy. Thus, in the past funding period, we used the B6-D2 mouse model to identify Kcnj10 as a putative seizure ..
- Mechanisms of comorbidity between epilepsy and depressionAndrey M Mazarati; Fiscal Year: 2010The long-term objective of the project is to understand mechanisms of co-morbidity between epilepsy and depression...
- The Role of Adenosine in Ketogenic Diet TherapySUSAN A contact MASINO; Fiscal Year: 2010b>Epilepsy affects approximately 1% of the population across all age groups and is one of the most prevalent chronic neurological disorders...
- Neuroactive Steroid Therapy of Catamenial EpilepsyDOODIPALA REDDY; Fiscal Year: 2007b>Epilepsy affects about 2.5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures...
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2011..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
- INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSYPAUL SCOTT BUCKMASTER; Fiscal Year: 2010Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2002b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2004b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
- Is Cerebral Malaria a Risk Factor for Epilepsy?Gretchen Birbeck; Fiscal Year: 2007Dr. Birbeck is a neuroepidemiologist interested in studying epilepsy in sub-Saharan Africa. Her tong-term goals include investigating common neurologic conditions that have often been understudied in developing countries...
- Middle Cerebral and Common Artery Occlusion and Poststroke EpilepsyKevin Kelly; Fiscal Year: 2007Poststroke seizures and epilepsy have been described in numerous clinical and population studies...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2010b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2007b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2009b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- Discovering More Juvenile Myoclonic Epilepsy Genes by a ConsortiumANTONIO V contact DELGADO ESCUETA; Fiscal Year: 2010For about 300,000 people in the USA with Juvenile Myoclonic Epilepsy (JME) and about 5 to 10 million persons, worldwide, with this disease, there is no cure...
- Discovering More Juvenile Myoclonic Epilepsy Genes by a ConsortiumANTONIO V contact DELGADO ESCUETA; Fiscal Year: 2010For about 300,000 people in the USA with Juvenile Myoclonic Epilepsy (JME) and about 5 to 10 million persons, worldwide, with this disease, there is no cure...
- Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007Hitten Zaveri; Fiscal Year: 2007b>Epilepsy is one of the most common neurological disorders affecting approximately 1% of the world's population...
- KYNURENINES, GLIA AND EPILEPSYRobert Schwarcz; Fiscal Year: 2006Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
- Potential Surrogate Marker of Epileptogenic CortexJoyce Wu; Fiscal Year: 2007..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
- Aberrant Neurogenesis in Experimental Temporal Lobe EpilepsyJack M Parent; Fiscal Year: 2010Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
- Aberrant Neurogenesis in Experimental Temporal Lobe EpilepsyJack Parent; Fiscal Year: 2009Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
- Neural Grafts and Injury-Induced Hippocampal DysfunctionAshok Shetty; Fiscal Year: 2009..head injury initially lead to epileptogenic changes, and then to hippocampal dysfunction exemplified by chronic epilepsy, and learning and memory impairments...
- NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATIONJOSE CAVAZOS; Fiscal Year: 2003b>Epilepsy is a major neurologic public health problem that affects an estimated 3 million Americans...
- Sodium Channel Gene Variation in the Treatment of EpilepsyKatherine Holland; Fiscal Year: 2009Initial antiepileptic treatment fails in over 40% of people with epilepsy, resulting in significant personal, financial, and societal hardships...
- Complementary treatment approach to epilepsySiegward Elsas; Fiscal Year: 2007..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
- Sodium Channel Gene Variation in the Treatment of EpilepsyKatherine D Holland; Fiscal Year: 2010Initial antiepileptic treatment fails in over 40% of people with epilepsy, resulting in significant personal, financial, and societal hardships...
- Genetic Study of Common Forms of EpilepsyHakon Hakonarson; Fiscal Year: 2009This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence ..
- Noninvasive Functional and Cellular Imaging of EpilepsyHuabei Jiang; Fiscal Year: 2010Approximately 2.5 million Americans live with epilepsy and epilepsy-related deficits today, more than disabled by Parkinson disease or brain tumors...
- Genetic Study of Common Forms of EpilepsyHAKON contact HAKONARSON; Fiscal Year: 2010This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence ..
- Childhood Absence Epilepsy Rx, PK-PD-PharmacogeneticsTracy Glauser; Fiscal Year: 2007DESCRIPTION (provided by the applicant): The optimal treatment for Childhood Absence Epilepsy (CAE), a common pediatric epilepsy syndrome affecting 10-15% of all children with epilepsy, and the basis for the inter-individual variation in ..
- Pilot: Levetiracetam to Prevent Post-Traumatic EpilepsyPavel Klein; Fiscal Year: 2006Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...


text:
KNOXVILLE, Tenn. (AP) - Tennessee pitcher Drake Owenby has pleaded guilty to a reduced charge of reckless driving nine months after a DUI arrest.
Owenby received a six-month suspended sentence Tuesday that also requires him to pay a $50 fine plus court costs. Owenby had been arrested on a DUI charge during an April 14 traffic stop by Knoxville police on Interstate 275.
Owenby, a sophomore left-hander, was 2-1 with a 5.60 ERA and two saves in 16 appearances as a freshman last season.
Tennessee athletic department spokesman Brian Bruce said that Owenby and Volunteers coach Dave Serrano declined comment on the matter.
The Vols open the season Feb. 14 against Nebraska-Omaha.
Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
441 Murfreesboro Road Nashville, TN 37210
Telephone: 615.369.7222
Fax: 615.369.7329
Email: email@example.com


text:
Situated 5km from Perth GPO.
¿Coolbinia¿ was for many years regarded as part of Mount Lawley. Development was mainly in the late 1940's and early 1950's and in 1953. The name chosen for a new school in the area in August 1953 was Coolbinia, an Aboriginal name meaning "Mistletoe" and it soon came to be adopted for the adjoining suburban area. Street names in Coolbinia commemorate many town and district names in Western Australia, eg., Carnarvon, Ardross, Marradon, Koorda etc.


text:
The firm's previous investments include Whole Foods, J. Crew, BJ's Wholesale Club and Jo- Ann Stores.
Leonard Green started raising money this year in an attempt to match its 2007 $5.3 billion fund, later capping it at $6 billion.
One observer noted that the size of the fund reflected a growing realization among private equity firms that mammoth size was inhibiting returns:
"There is more pressure at the large end of the market to come back in smaller size as it is more difficult to put out large amounts of capital in what is a debt-constrained market," said Kelly DePonte, a partner at Probitas Partners LLC, a San Francisco-based firm that helps funds raise money.
Michael Gennaro, Leonard Green's chief operating officer, declined to comment on fundraising.