text:
Research Topics
Genomes and Genes
Gene Symbol: SLC17A5
Description: solute carrier family 17 (acidic sugar transporter), member 5
Alias: AST, ISSD, NSD, SIALIN, SIASD, SLD, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter, membrane glycoprotein HP59, sialic acid storage disease, sialin, sodium/sialic acid cotransporter, solute carrier family 17 (anion/sugar transporter), member 5, vesicular H(+)/Aspartate-glutamate cotransporter
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications161 found, 100 shown here
- Pruritus in chronic hepatitis C: association with high serum bile acids, advanced pathology, and bile duct abnormalitiesE Lebovics
Department of Medicine, New York Medical College, Valhalla 10595, USA
Dig Dis Sci 42:1094-9. 1997..Pruritus was present in nine (5.1%) patients. Serum AST, ALT, alkaline phosphatase, GGTP, total bilirubin, and ferritin were similar in pruritics and controls...
- [Five cases of erythema infectiosum in adults]T Takahashi
Department of Medicine, Yame General Hospital
Kansenshogaku Zasshi 75:469-72. 2001..Rheumatoid factor (RF) was also detected by latex fixation test. Her AST was 51 IU/L, ALT 68 IU/L and LDH 568 IU/L...
- Prevalence of hepatitis B and C virus markers in outpatients of Mongolian general hospitalsS Fujioka
First Department of Internal Medicine, Okayama University Medical School
Kansenshogaku Zasshi 72:5-11. 1998..05). Transaminase levels were higher in group 1 (median (range) IU/l of AST, ALT; 29 (13-95), 32 (9-144) and group 3 (25 (15-187), 22 (8-185)) than in group 4 (18 (9-13), 15 (6-133); p < 0...
- Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in ratsIsmail Celik
Faculty of Art and Science, Department of Biology, Yuzuncu Yil University, Van, Turkey
Nat Prod Res 22:66-75. 2008..of the plant infusions were evaluated by measuring levels of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), creatine phosphokinase (CPK), acid phosphatase (ACP), alkaline phosphatase (ALP) ..
- Growth hormone and carbohydrate intolerance in cirrhosisT P Shankar
Department of Medicine, VA Medical Center, Memphis, Tennessee
Horm Metab Res 20:579-83. 1988..Glucose tolerance tests (GTT), intravenous insulin tolerance tests (IVITT), arginine stimulation tests (AST) and glucose clamp studies before and during GH suppression with somatostatin were performed in a group of patients ..
- [A case of neonatal herpes infection which proved to be a mixed infection of herpes simplex virus type 1 and type 2]Y Minohara
Department of Pediatrics, St. Marianna University, School of Medicine
Kansenshogaku Zasshi 70:627-30. 1996..b>AST was 1042 IU/L, and ALT 206 IU/L. In spite of treatment, the patient died at the age of 12 days...
- Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusionG den Butter
Department of Surgery, University of Wisconsin, Madison 53792, USA
Transpl Int 8:466-71. 1995..LDH and AST release were greater in HTK-preserved livers than in UW livers, but these differences were not statistically ..
- Clinical, biochemical, and molecular diagnosis of a free sialic acid storage disease patient of moderate severityRobert Kleta
Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Mol Genet Metab 82:137-43. 2004The allelic autosomal recessive lysosomal storage disorders Salla disease and infantile free sialic acid storage disease (ISSD) result from mutations in SLC17A5...
- Relationship of the subgingival microbiota to a chairside test for aspartate aminotransferase in gingival crevicular fluidM Y Wong
School of Dentistry, College of Medicine, National Taiwan University, Taipei
J Periodontol 70:57-62. 1999The aim of the present study was to evaluate the association between the occurrence of certain specific periodontal pathogens and aspartate aminotransferase (AST) levels in gingival crevicular fluid (GCF).
- Changes in vitamin E concentration after surgery and anesthesiaJ Zunic
Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia
Coll Antropol 21:327-34. 1997..Simultaneously activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) were determined. Statistical analysis: ANOVA, Tukay HSD test...
- Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPATL G Larsson
Department of Neuropharmacology, CNS 1, Astra Research Centre, , Sweden
Neuropharmacology 29:85-91. 1990..hippocampus and hypothalamus, after inhibition of L-aromatic amino acid decarboxylase by 3-hydroxybenzylhydrazine (NSD 1015), that is due to stimulation of autoreceptors on the 5-HT cell bodies...
- Prenatal diagnosis of free sialic acid storage disorders (SASD)Nina Aula
Neuroscience Center, University of Helsinki, Finland
Prenat Diagn 26:655-8. 2006Free sialic acid storage disorders, Salla disease (SD) and Infantile sialic acid storage disease (ISSD), are lysosomal storage diseases due to impaired function of a sialic acid transporter, sialin, at the lysosomal membrane...
- Autonomic stress tests in obstructive sleep apnea syndrome and snoringD Veale
Department of Pneumonology, CHRU, Grenoble, France
Sleep 15:505-13. 1992..A significant difference between normal abnormal autonomic stress test (AST) groups was observed in the evening and the morning as regards cumulative time spent under 90% SaO2 and minimal ..
- [Drug-induced hepatotoxicity caused by anti-tuberculosis drugs in tuberculosis patients complicated with chronic hepatitis]Yugo Kaneko
Department of Pulmonary Medicine, Jikei University School of Medicine, 4 11 1, Izumihoncho, Komae shi, Tokyo 201 8601, Japan
Kekkaku 83:13-9. 2008....
- The lysosomal sialic acid transporter sialin is required for normal CNS myelinationLaura M Prolo
Department of Neurology and Neurological Sciences and Graduate Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 29:15355-65. 2009Salla disease and infantile sialic acid storage disease are autosomal recessive lysosomal storage disorders caused by mutations in the gene encoding sialin, a membrane protein that transports free sialic acid out of the lysosome after it ..
- Novel form of intermediate salla disease: clinical and neuroimaging featuresRichard P Morse
Department of Pediatrics, Division of Pediatric Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Child Neurol 20:814-6. 2005..Infantile sialic acid storage disease has a severe phenotype, and Salla disease (Finnish variant) is generally milder in phenotype; ..
- Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigsMeghna R Adhvaryu
Bapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, 110, Nehru Nagar Society, Ichchhanath Road, Surat 395007, India
World J Gastroenterol 13:3199-205. 2007....
- Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trialsEdwin K Kuffner
McNeil Consumer Healthcare, Division of McNeil PPC, Inc, Fort Washington, PA 19034, USA
Curr Med Res Opin 22:2137-48. 2006..9 g daily than in patients receiving placebo, and the rates were higher than aminotransferase values observed in some previous osteoarthritis studies with acetaminophen...
- Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis BJie Shao
Department of Hepatic Disease, People s Hospital, Peking University, Beijing 100034, China
World J Gastroenterol 13:2104-7. 2007..To study the relationship between hepatitis B virus (HBV) DNA levels and liver histology in patients with chronic hepatitis B (CHB) and to determine the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative patients...
- A pilot study to compare natural health product-drug interactions in two databases in CanadaGuillaume Faubert
Pharmacy Department, Pharmaceutical Practice Research Unit, CHU Sainte Justine, 3175, Chemin de la Cote Ste Catherine, Montreal, QC, H3T 1C5, Canada
Pharm World Sci 32:179-86. 2010..The aim of this article is to evaluate and compare two natural health product databases for the purpose of integrating them into a pharmacy information system in Canada...
- Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3',5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chickenR Vasilatos-Younken
Department of Poultry Science, Pennsylvania State University, University Park, Pennsylvania, 16802, USA
Gen Comp Endocrinol 105:31-9. 1997..The recessive sex-linked dwarfing (SLD) gene (dw) in chickens results in a lack of functional target tissue GH receptors due to a variety of molecular ..
- [Effects of astragaloside and Panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice]Hua Tan
Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
Zhong Xi Yi Jie He Xue Bao 8:448-52. 2010To investigate the influence of astragaloside (AST) and Panax notoginseng saponins (PNS) combination on oxidative stress of brain tissues in C57BL/6 mice with cerebral ischemia-reperfusion injury.
- Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidantsS A Sheweita
Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, P O Box 832, 163 Horreya Avenue, Alexandria, Egypt
Toxicology 165:217-24. 2001..tetrachloride-induced changes in the activity of alanine amino transferase (ALT), aspartate amino transferase (AST), glutathione S-transferase (GST), and the level of glutathione (GSH) and thiobarbituric acid reactive substances (..
- Early fractionation methods and the origins of the NSD conceptH D Thames
Department of Biomathematics, University of Texas System Cancer Center, Houston 77030
Acta Oncol 27:89-103. 1988..of fraction number and overall time could be separated; these developments constituted the foundation of the Ellis NSD model...
- Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in ratsRu Tao Hong
Department of Geriatrics Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
World J Gastroenterol 15:1452-8. 2009..To investigate the protective effects of melatonin on carbon tetrachloride (CCl4)-induced hepatic fibrosis in experimental rats...
- Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changesPascal Courville
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 285:19316-23. 2010Salla disease and infantile sialic acid storage disorder are human diseases caused by loss of function of sialin, a lysosomal transporter that mediates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out ..
- Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teethGiuseppe Perinetti
Unit of Orthodontics, Department of Oral Sciences, School of Dentistry, University G D Annunzio, Chieti, Italy
J Clin Periodontol 31:60-7. 2004..of Actinobacillus actinomycetemcomitans (Aa) and alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activities in gingival crevicular fluid (GCF) in order to assess whether these parameters have potential as ..
- Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injuryQing Zhao Shi
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
World J Gastroenterol 16:897-903. 2010..To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses, assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury...
- High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathyDavid Stejskal
Metabolic and Diabetologic Out Patient Centre and Department of Laboratory Medicine, Hospital Sternberk, Czech Republic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:93-9. 2005..for serum concentrations of AN, glucose, triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamate transferase (GMT) activity; carbohydrate-deficient transferrin (CDT%) a marker of chronic alcohol ..
- Prevalence of enterotoxin genes in Aeromonas spp. isolated from children with diarrhea, healthy controls, and the environmentM J Albert
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
J Clin Microbiol 38:3785-90. 2000..Recently, we have characterized a heat-labile cytotonic enterotoxin (Alt), a heat-stable cytotonic enterotoxin (Ast), and a cytotoxic enterotoxin (Act) from a diarrheal isolate of Aeromonas hydrophila...
- Gemfibrozil-induced myositis in a patient with normal renal functionMartin Hahn
Tennessee Valley Health Care System, Nashville, TN 37129, USA
Ann Pharmacother 44:211-4. 2010..To describe a case of gemfibrozil monotherapy-induced myositis in a patient with normal renal function..
- Heparin sensitivity test for patients requiring cardiopulmonary bypassWilliam J DeBois
New York Presbyterian Hospital Weill Cornell Medical Center, NY 10021, USA
J Extra Corpor Technol 38:307-9. 2006..An anticoagulation sensitivity test (AST) was developed by adding 12 units of porcine mucosa heparin to the ACT tube (International Technidyne, celite type)...
- Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brainA Brambilla
Department of Biology, Boehringer Ingelheim Italia, Milan, Italy
Eur Neuropsychopharmacol 10:63-7. 1999..5-HTP) after blockade of aromatic amino acid decarboxylase induced by m-hydroxybenzylhydrazine (NSD-1015), at 100 mg/kg i.p., 30 min before sacrifice...
- Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activationMiao Xian Dong
The Institute of Medicine, Qiqihar Medical University, JianHua District, Qiqihar, Heilongjiang Province, China
World J Gastroenterol 15:4753-62. 2009..To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl(4)) in rats and to further explore the underlying mechanisms...
- Modulation of key metabolic enzyme of Labeo rohita (Hamilton) juvenile: effect of dietary starch type, protein level and exogenous alpha-amylase in the dietShivendra Kumar
Department of Fish Nutrition and Biochemistry, Central Institute of Fisheries Education, Versova, Mumbai 400061, India
Fish Physiol Biochem 35:301-15. 2009..dehydrogenase, G6PD) and amino acid metabolism (alanine amino transferase, ALT and aspartate amino transferase, AST) in Labeo rohita. Three hundred and sixty juveniles (average weight 10 +/- 0...
- Comparison of blood aminotransferase methods for assessment of myopathy and hepatopathy in Florida manatees (Trichechus manatus latirostris)Kendal E Harr
FVP Consultants, Inc, Bushnell, Florida 33513, USA
J Zoo Wildl Med 39:180-7. 2008Muscle injury is common in Florida manatees (Trichechus manatus latirostris). Plasma aspartate aminotransferase (AST) is frequently used to assess muscular damage in capture myopathy and traumatic injury...
- Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortalityV Arndt
Department of Epidemiology, University of Ulm, Germany
Int Arch Occup Environ Health 71:405-12. 1998Gamma-glutamyl transferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) are widely used as markers of hepatobiliary disorders in occupational health surveillance...
- Scapholunate dissociation: an experimental kinematic study of two types of indirect soft tissue repairsA B Dagum
Department of Surgery, University of Toronto, Ontario, Canada
J Hand Surg Am 22:714-9. 1997Indirect soft tissue repairs of scapholunate dissociation (SLD) address the pathophysiology but have been criticized for significantly limiting wrist flexion and altering wrist kinematics...
- Nasal septum deviation in newbornsA Soboczyński
ORL Clinic, Academy of Medicine, Poznan, Poland
Acta Otorhinolaryngol Belg 46:263-5. 1992The patency of the nose is very important for the newborn. Nasal septum deviation (NSD) is one of the most important factors causing disorders of the patency of the nose. It is usually the result of mechanical trauma...
- [How brain-dead state affects the hepatic morphology and function of Ba-Ma mini pigs and its mechanism]Shui jun Zhang
Department of General Surgery, The First Affiliated Hospital, Zhenzhou University, Zheng Zhou 450052, China
Zhonghua Yi Xue Za Zhi 86:1244-8. 2006..To investigate the impact of brain death (BD) on the morphology and function of liver...
- Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv)F Arguello
Strong Children s Research Center, University of Rochester School of Medicine, New York 14642
Cancer Res 52:2304-9. 1992..26 melanoma cells into mutant Sl/Sld and W/Wv mice...
- Protective effects of L-arginine against ischemia-reperfusion injury in non-heart beating rat liver graftJin Gong
Department of Surgery, First Affiliated Hospital, Jinan University, Guangzhou 510630, China
Hepatobiliary Pancreat Dis Int 7:481-4. 2008..Prevention of liver injury in NHBDs will benefit the results of transplantation. This study was conducted to evaluate the protective effects of L-arginine on liver grafts from NHBDs...
- Aspartat aminotransferase--a marker of periodontal disease activityM Ivić-Kardum
Department of Periodontology, School of Dental Medicine, Zagreb, Croatia
Coll Antropol 23:111-6. 1999..Aspartat aminotransferase (AST) activity in gingival crevicular fluid is a potential quantitative marker of periodontal disease activity...
- Safety and efficacy of combined ezetimibe/simvastatin treatment and simvastatin monotherapy in patients with non-alcoholic fatty liver diseaseTatjana Abel
Outpatient Department, National Health Centre, Budapest, Hungary
Med Sci Monit 15:MS6-11. 2009..The secondary goal of this investigation was to compare the safety and efficacy of combined ezetimibe / simvastatin treatment with simvastatin monotherapy...
- Glutathione S-transferase Alpha 1-1 and aminotransferases in umbilical cord bloodM F Knapen
Department of Obstetrics and Gynecology, University Hospital St Radboud, Nijmegen, Netherlands
Early Hum Dev 54:129-35. 1999..with that of the well known liver function markers alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in arterial and corresponding venous umbilical cord blood of 93 patients...
- Sleep deprivation affects speechY Harrison
Loughborough University, Leicestershire
Sleep 20:871-7. 1997..subjects underwent two counterbalanced 36-hour trials involving sleep deprivation (SD) and no sleep deprivation (NSD)...
- Bioavailability of astaxanthin stereoisomers from wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon in healthy men: a randomised, double-blind studyCorinna E Rüfer
Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Karlsruhe, Germany
Br J Nutr 99:1048-54. 2008..was to investigate the bioavailability and the configurational isomer distribution of the carotenoid astaxanthin (AST) in human plasma after ingestion of wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon...
- Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative processGregory L Willis
The Bronowski Institute of Behavioural Neuroscience, Neurosciences Section, Coliban Medical Centre, Kyneton, Victoria, Australia
Rev Neurosci 19:245-316. 2008For more than 50 years, Parkinson's disease (PD) has been conceptualized as a product of nigro-striatal dopamine (NSD) system degeneration...
- Multiplex PCR method for detection of three Aeromonas enterotoxin genesCesar I Bin Kingombe
Microbiology Research Division, Bureau of Microbial Hazards, Food Directorate, Health Products and Food Branch, Sir Frederick G Banting Research Centre, Ottawa, Ontario, Canada
Appl Environ Microbiol 76:425-33. 2010..of specific primers was developed for the detection of the cytotoxic (act), heat-labile (alt), and heat-stable (ast) enterotoxin genes in Aeromonas spp...
- Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. A controlled short-term longitudinal studyGiuseppe Perinetti
Unit of Biochemistry, Department of Oral Sciences, Dental School, University G D Annunzio, Chieti, Italy
J Periodontol 74:145-52. 2003..This study used a longitudinal design to examine aspartate aminotransferase (AST) activity in gingival crevicular fluid (GCF) in order to assess whether AST in GCF has potential as a possible ..
- Demonstration of antihistamine properties with AST-1: a bioactive extract from garden slugs (Diplosolenodes occidentalis)A Jacob
Department of Basic Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
West Indian Med J 56:11-6. 2007..to histamine from allergic sensitization, the authors investigated the effects of a semi-pure alcoholic extract (AST-1) on histamine-induced contraction of the guinea pig in vitro tracheal muscle preparation and cutaneous allergic ..
- Frequency of inappropriate continuation of acid suppressive therapy after discharge in patients who began therapy in the surgical intensive care unitCatherine E Murphy
Department of Pharmacotherapy, Fletcher Allen Health Care, Burlington, Vermont, USA
Pharmacotherapy 28:968-76. 2008To determine the frequency with which patients who begin to receive stress ulcer prophylaxis in the surgical intensive care unit (SICU) are discharged receiving inappropriate acid suppressive therapy (AST).
- [The changes and significance of multiple organ functions in acute pancreatitis patients under hypoxic condition on plateau]Hai Hong Zhu
Department of General Surgery, People s Hospital of Qinghai Province, Xining 810007, Qinghai, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:210-3. 2010..To explore characteristics of the pathogenesis and progression of the acute pancreatitis (AP) in high altitude and the relationship between AP and plateau erythrocythemia...
- Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPAHun Kyu Ryeom
Department of Radiology, Kyungpook National University School of Medicine, Taegu, Korea
Korean J Radiol 5:231-9. 2004..The purpose of this study is to develop a noninvasive method of quantitation of the hepatic function using Gd-EOB-DTPA through the deconvolution analysis...
- [Three cases with acute encephalopathy related with adenovirus type 7 infection]N Ohtsuki
Department of Pediatrics, Urafune Hospital of Yokohama City University, School of Medicine
No To Hattatsu 32:68-72. 2000..Seizures in all the patients developed from 8 to 10 days after the onset of pyrexia. The values of serum AST, LDH and CRP elevated and those of WBC and serum protein decreased at the onset of encephalopathy...
- Inflation of antishock trousers increases bronchial response to methacholine in healthy subjectsJ Regnard
Laboratoire de Physiologie, Faculté de Médecine Cochin Port Royal, Paris, France
J Appl Physiol (1985) 68:1528-33. 1990..changes in lung volumes and in bronchial response to methacholine chloride (MC) challenge when antishock trousers (AST) were inflated at venous occlusion pressure in healthy subjects in the standing posture, a maneuver known to shift ..
- Diagnostic accuracy of plain radiographs and cineradiography in diagnosing traumatic scapholunate dissociationJenny Pliefke
Department of Hand Surgery, Replantation Surgery, and Microsurgery, Unfallkrankenhaus Berlin, Warener Strasse 7, 12683 Berlin, Germany
Skeletal Radiol 37:139-45. 2008Missed tears of the scapholunate ligament (SLL) and scapholunate dissociation (SLD) after wrist injuries pose a high risk of post-traumatic osteoarthritis of the carpus...
- [Evaluation of automated architect syphilis TP as a diagnostic laboratory screening test for syphilis]Jeeyong Kim
Department of Laboratory Medicine, Korea University Hospital, Seoul, Korea
Korean J Lab Med 28:475-82. 2008..The aim of the study was to establish a new syphilis test algorithm using Architect Syphilis TP (Abbott Japan, Japan: AST), a fully automated treponemal antibody test, as a screening test in a university hospital laboratory...
- Relationship between crevicular aspartate aminotransferase levels and periodontal disease progressionR J Oringer
Department of Periodontics, State University of New York at Stony Brook, 11794 8703, USA
J Periodontol 72:17-24. 2001Aspartate aminotransferase (AST), an enzyme released from necrotic cells, has been identified in gingival crevicular fluid (GCF), and elevated levels are associated with periodontal tissue destruction...
- Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomideJ R Curtis
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 510 20 Street South, FOT 840, Birmingham, AL 35294, USA
Ann Rheum Dis 69:43-7. 2010..RA) or psoriatic arthritis (PsA), the incidence of elevated alanine aminotransferase/aspartate aminotransferase (ALT/AST) enzymes associated with methotrexate (MTX), leflunomide (LEF) and MTX+LEF versus other DMARDs was examined.
- Spontaneous radiation-induced rib fractures in breast cancer patients treated with postmastectomy irradiation. A clinical radiobiological analysis of the influence of fraction size and dose-response relationships on late bone damageM Overgaard
Department of Oncology and Radiotherapy, Radiumstationen, Aarhus, Denmark
Acta Oncol 27:117-22. 1988..6%) even though they had been treated with the aim to obtain equivalent biologic response according to the NSD formula...
- [Clinical studies on 35 patients with infection-related acute encephalopathy]S Kimura
Department of Pediatrics, Urafune Hospital of Yokohama City University School of Medicine
No To Hattatsu 30:244-9. 1998..Serum AST were elevated in 7.7 and 6 cases in (3), (4) and (5), respectively...
- Comparison between fractionated high dose rate irradiation and continuous low dose rate irradiation in spheroidsM Omura
Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan
Acta Oncol 37:681-6. 1998..was independent of the fraction size of HDR irradiation administrated, and the repair of sublethal damage (SLD) was absent, suggesting that the sparing effect of fractionated HDR irradiations was absent in spheroids...
- Allatostatin-like immunoreactivity in the abdomen of the locust Schistocerca gregariaPetra Skiebe
Institut fur Biologie, Fachbereich Biologie, Chemie, Pharmazie, Neurobiologie, Freie Universitat Berlin, Königin Luise Strasse 28 30, 14195 Berlin, Germany
Cell Tissue Res 325:163-74. 2006A polyclonal antibody against allatostatin 1 (AST-1) of cockroach Diploptera punctata was used to investigate the distribution of AST-like immunoreactivity within the abdomen of the locust, Schistocerca gregaria...
- Ameliorating effect of phytoestrogens on CCl4-induced oxidative stress in the livers of male Wistar ratsRitu Aneja
Department of Chemistry, University of Delhi, Delhi, India
Artif Cells Blood Substit Immobil Biotechnol 33:201-13. 2005..tetrachloride (CCl4) induced changes in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione S transferase (GSH) and levels of glutathione (GSH) and thiobarbituric acid reactive substances (..
- Mitigation of gamma-radiation induced abasic sites in genomic DNA by dietary nicotinamide supplementation: metabolic up-regulation of NAD(+) biosynthesisVipen Batra
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India Electronic address
Mutat Res 749:28-38. 2013..underlying mechanism(s), male Swiss mice were maintained on control diet (CD) and nicotinamide supplemented diet (NSD)...
- Normal coordinate structural decomposition of the heme distortions of hemoglobin in various quaternary states and bound to allosteric effectorsMonique Laberge
Institute of Biophysics and Radiation Biology, Semmelweis University, Puskin u 9, Budapest H 1088, Hungary
Mol Divers 7:15-23. 2003..was investigated by subjecting CHARMM energy-minimized models to normal coordinate structural decomposition (NSD) analysis...
- Quantification and visualization of Dippu-AST mRNA in the brain of adult Diploptera punctata: mated females vs. virgin females vs. malesChris S Garside
Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
J Insect Physiol 49:285-91. 2003..We have investigated the levels of AST expression in the brain of adult mated and virgin females, and adult males of the cockroach Diploptera punctata, ..
- Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell lineFrancesca Carubbi
Dipartimento di Medicina Interna, Universita degli Studi di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
Biochim Biophys Acta 1580:31-9. 2002..Culture media, harvested at the end of each incubation period, were analyzed to evaluate aspartate transaminase (AST), alanine transaminase and gamma-glutamyltranspeptidase release...
- Angiostatin II is the predominant glycoform in pleural effusates of rabbit VX-2 lung tumorsMark W C Hatton
Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
J Lab Clin Med 139:316-23. 2002Angiostatin (AST), a polypeptide with potent antiangiogenic properties, is released proteolytically from plasminogen in vivo. Plasminogen exists naturally in plasma as two glycoforms (PLGs), I and II...
- Effects of oral adsorbent AST-120 (Kremezin) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized ratsNoriyoshi Kobayashi
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Nephron 91:480-5. 2002The aim of the present study was to determine if treatment with an oral adsorbent (AST-120, Kremezin) might decrease the urinary albumin excretion and serum indoxyl sulfate (s-IS), and prevent glomerular sclerosis in early-stage renal ..
- nsd, a locus that affects the Myxococcus xanthus cellular response to nutrient concentrationMargaret Brenner
Section of Microbiology and Center for Genetics and Development, The University of California, Davis, Davis, California 95616, USA
J Bacteriol 186:3461-71. 2004..Our analysis shows that the gene fusion is located in an open reading frame that we have designated nsd (nutrient sensing/utilizing defective) and that its expression is driven by a sigma70-like promoter...
- Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesisD P Ringer
Biochemical Pharmacology Section, Samuel Roberts Noble Foundation, Inc, Ardmore, Oklahoma
Mol Carcinog 9:2-9. 1994..basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis...
- [Secular increase in the incidence rate of drug-induced hepatitis due to anti-tuberculosis chemotherapy including isoniazid and rifampicin]Naohiro Nagayama
Department of Respiratory Medicine, Tokyo National Hospital, 3 1 1, Takeoka, Kiyose shi, Tokyo 204 8585, Japan
Kekkaku 78:339-46. 2003..The criteria for selection of the patients were as follows. 1. The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured before, and one month (20-40 days) and 2 months (45-75 days) ..
- Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group studyTimothy W Synold
City of Hope Comprehensive Cancer Center, Duarte, California, USA
Clin Cancer Res 13:3660-6. 2007..To determine the toxicities, pharmacokinetics, and maximally tolerated doses of oxaliplatin in patients with hepatic impairment and to develop formal guidelines for oxaliplatin dosing in this patient population...
- Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency)Ken H Darzy
Department of Endocrinology, Christie Hospital, Manchester, UK
Clin Endocrinol (Oxf) 70:287-93. 2009..reserve as indicated by substantially reduced group GH responses to the GHRH + arginine stimulation test (AST)...
- Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmonRandal A Wolff
William S Middleton Memorial Veterans Hospital and University of Wisconsin Medical School, Madison, Wisconsin 53792 3236, USA
J Vasc Surg 43:1028-36. 2006..Transforming growth factor beta-1 (TGF-beta1) is a pleiotropic cytokine known to have powerful effects on cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis...
- Nicotine stimulates secretion of corticosterone via both CRH and AVP receptorsKabirullah Lutfy
Division of Endocrinology, Molecular Medicine and Metabolism, Department of Internal Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurochem 120:1108-16. 2012..We used the CRH-R1-specific antagonist, antalarmin (ANT), the CRH-R1 and CRH-R2 peptide antagonist, astressin (AST), and the CRH-R2-specific peptide antagonist, astressin2b (AST2b), to determine which CRH receptor is involved in ..
- The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decayBiswadip Das
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
J Biol Chem 288:14742-55. 2013The autosomal recessive mutation, sld, attenuates mucous cell expression in murine sublingual glands with corresponding effects on mucin 19 (Muc19)...
- Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney diseaseShunsuke Ito
Department of International Health Development, Tokyo Medical and Dental University, Tokyo, Japan
J Leukoc Biol 93:837-45. 2013..An oral adsorbent, AST-120, retards renal function deterioration by lowering IS, which is known to accumulate in CKD patients...
- Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney DiseaseShingo Hatakeyama
Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu chou, Hirosaki 036 8562, Japan
Int J Nephrol 2012:376128. 2012The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis...
- Comparative study of C-reactive protein and other biochemical parameters in patients with hepatitis B and malaria in Calabar, NigeriaU K Amah
Department of Chemical Pathology, College of Medicine, Nnamdi Azikiwe University, Nnewi Campus
Niger J Physiol Sci 26:109-12. 2011Serum levels of C-reactive proteins (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin and globulins were investigated using high sensitivity immunoturbidometric and colorimetric techniques in ..
- Effects of bone and mineral metabolism on arterial elasticity in chronic renal failureEva Kis
First Department of Pediatrics, Semmelweis University, Budapest Bókay János u 53 54, 1083, Hungary
Pediatr Nephrol 24:2413-20. 2009Arterial stiffness (Ast) individually predicts cardiovascular (CV) mortality. Ast increases via vascular calcification and can be characterized by pulse wave velocity (PWV)...
- Validation of three non-invasive markers in assessing the severity of liver fibrosis in chronic hepatitis CSamiullah Shaikh
Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad
J Coll Physicians Surg Pak 19:478-82. 2009To compare various biochemical markers i.e. APRI (AST to platelet ratio index), aspartate aminotransferase (AST) alanine aminotransferase (ALT) ratio, FIB-4 (AST, platelet, AST and age) with biopsy for assessing the severity of hepatic ..
- [Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats]Yan Ding
Department of Gastroenterology and Hepatology, Medical and Health Center for Women and Children, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Zhonghua Yi Xue Za Zhi 89:699-703. 2009..To investigate the therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof...
- Pediatric FAST and elevated liver transaminases: An effective screening tool in blunt abdominal traumaJuan E Sola
DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Florida, USA
J Surg Res 157:103-7. 2009..We sought to determine if the focused assessment with sonography for trauma (FAST) combined with elevated liver transaminases (AST/ALT) could be used as a screening tool for intra-abdominal injury (IAI) in pediatric patients with BAT.
- Free sialic acid storage disease without sialuriaFanny Mochel
Institut National de la Sante et de la Recherche Médicale UMR S679, Hopital La Salpetriere, Paris, France
Ann Neurol 65:753-7. 2009..Both patients were homozygous for the K136E mutation in SLC17A5, the gene responsible for the free sialic acid storage diseases...
- FGLamide Allatostatin genes in Arthropoda: introns early or late?Francisco Martínez-Pérez
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Peptides 30:1241-8. 2009..The FGLamide allatostatin (AST) gene structure in Dictyoptera is intronless within the ORF, whereas in 9 species of Diptera, the FGLamide AST ORF ..
- [Effect of oral adsorbent AST-120 under standard treatment of care in patients with chronic renal failure]Izumi Yoshida
Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan
Nihon Jinzo Gakkai Shi 51:121-9. 2009Oral adsorbent AST-120 reduces uremic toxins, such as indoxyl sulfate, and retards the progression of chronic kidney disease (CKD)...
- Growth hormone receptor gene expression in sex-linked dwarf Leghorn chickens: evidence against a gene deletionK L Hull
Department of Physiology, University of Alberta, Edmonton, Canada
J Endocrinol 137:91-8. 1993..been identified in peripheral (liver and muscle) and central (brain and hypothalamus) tissues of sex-linked dwarf (SLD) Leghorn chickens...
- Clinical and financial benefits of rapid bacterial identification and antimicrobial susceptibility testingJ Barenfanger
Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781, USA
J Clin Microbiol 37:1415-8. 1999..time period, the vast majority of bacterial identification and antimicrobial susceptibility testing (AST) results were verified with the Vitek system on the same day that they were available...
- Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cureA Colao
Department of Molecular and Clinical Endocrinology, Federico II University, Naples, Italy
J Clin Endocrinol Metab 84:2664-72. 1999..systolic and diastolic media-media distances, blood systolic (SPV) and diastolic (DPV) peak velocity, systolic (SLD) and diastolic (DLD) lumen diameter, and distensibility coefficient (DC) were measured at both common carotid ..
- Prevalence and long-term course of macro-aspartate aminotransferase in childrenMaria Caropreso
Department of Pediatrics, University of Naples Federico II, Naples, Italy
J Pediatr 154:744-8. 2009To investigate the prevalence, association with clinical conditions, and long-term course of macro-aspartate aminotransferase (macro-AST).
- Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot studyIrina A Kirpich
Department of Biochemistry, Northern State Medical University, 161020, Arkhangelsk, Russia
Alcohol 42:675-82. 2008..43 vs. 5.5 log CFU/g). The mean baseline alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) activities were significantly elevated in the alcoholic group compared to ..
- Cloning, characterisation and heterologous expression of an astacin metalloprotease, Sc-AST, from the entomoparasitic nematode Steinernema carpocapsaeYingjun Jing
CIRN and Department of Biology, University of Azores, Ponta Delgada, Azores, Portugal
Mol Biochem Parasitol 174:101-8. 2010..motif and a methionine turn motif; therefore, this protein was identified as an astacin and designated as Sc-AST. The astacin domain of Sc-AST has an amino acid sequence homology of 46% to prototypical astacin from Astacus ..
- Genomic analysis reveals Nairobi sheep disease virus to be highly diverse and present in both Africa, and in India in the form of the Ganjam virus variantPragya D Yadav
Microbial Containement Complex, National Institute of Virology, Sus Road, Pashan, Pune 410021, India
Infect Genet Evol 11:1111-20. 2011Nairobi sheep disease (NSD) virus, the prototype tick-borne virus of the genus Nairovirus, family Bunyaviridae is associated with acute hemorrhagic gastroenteritis in sheep and goats in East and Central Africa...
- Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2P B Jacobson
Department of Immunopathology, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, MI 48105
J Immunol 151:5639-52. 1993..The selective inhibition of PLA2 by the marine natural products manoalide (MLD) and scalaradial (SLD) blocks [3H]arachidonic acid (AA) release in calcium ionophore A23187-stimulated neutrophils, and also inhibits ..
- Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stressHideki Fujii
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
Nephrol Dial Transplant 24:2089-95. 2009..Increased oxidative stress plays a role in the pathogenesis of CVD in CKD patients. The oral charcoal adsorbent AST-120 attenuates the progression of CKD possibly by removing uraemic toxins such as indoxyl sulfate (IS), and reduces ..
- Sleep disturbance in dementia with Lewy bodies and Alzheimer's disease: a multicenter analysisDonald L Bliwise
Department of Neurology, Emory University School of Medicine, Wesley Woods Health Center, 1841 Clifton Road, Atlanta, GA 30329, USA
Dement Geriatr Cogn Disord 31:239-46. 2011..We sought to confirm such observations using a large, prospectively collected, standardized, multicenter-derived database, i.e. the National Alzheimer's Coordinating Center Uniform Data Set...
- Creatine phosphokinase and aspartate aminotransverase profiles and its relation to the severity of uterine torsion in Egyptian buffaloS M Amin
Department of Theriogenology, Faculty of Veterinary Medicine, Zagazig University, El Zeraa Str 114, 44519 Zagazig, Egypt
Anim Reprod Sci 123:163-8. 2011..the relationship between the serum concentrations of creatine phosphokinase (CPK), aspartate aminotransverase (AST) and the severity of uterine torsion...
- Reduction in physician reimbursement and use of hormone therapy in prostate cancerSean P Elliott
Department of Urologic Surgery, University of Minnesota, 420 Delaware St SE, MMC 394, Minneapolis, MN 55455, USA
J Natl Cancer Inst 102:1826-34. 2010Use of androgen suppression therapy (AST) in prostate cancer increased more than threefold from 1991 to 1999...
Research Grants65
- Relationship of metabolic abnormalities to hepatic steatosis in HIVRichard Sterling; Fiscal Year: 2007..In our HIV population without HCV or HBV, there is a higher prevalence of abnormal liver enzymes (AST 21%, ALT 16%, ALP 43%) compared to the general population (ALT 8%) and is independently associated with PI use...
- Role of 5-alpha Reductase in Testosterone ActionsShalendar Bhasin; Fiscal Year: 2007..For safety, we will follow hemoglobin/hematocrit, sleep apnea scores, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, and prostate examinations...
- High resolution functional MRI of columnar structuresRavi Menon; Fiscal Year: 2007..The techniques we will use to accomplish this are fMRI (BOLD and AST based), electrophysiology, fluorescence quenching, laser Doppler and near-infrared spectroscopy at high spatial and ..
- Avoiding toxicity associated with MTP ablationM Mahmood Hussain; Fiscal Year: 2010..However, they increase plasma aminotransferases, such as ALT and AST, indicating liver injury...
- Pontine Control of REM AtoniaElda Arrigoni; Fiscal Year: 2010..Considerable evidence demonstrates that neurons of the sublaterodorsal (SLD) nucleus of the pons, also known as the subcoreuleus, generate muscle atonia during REM sleep...
- Pontine Control of REM AtoniaElda Arrigoni; Fiscal Year: 2009..Considerable evidence demonstrates that neurons of the sublaterodorsal (SLD) nucleus of the pons, also known as the subcoreuleus, generate muscle atonia during REM sleep...
- TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MENShalender Bhasin; Fiscal Year: 2005..For safety, we will follow hematocrit, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, digital rectal examinations, and sleep ..
- Testosterone:Physical Function in Men on HemodialysisShalender Bhasin; Fiscal Year: 2004..For safety, we will follow hemoglobin/hematocrit, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, and insulin sensitivity by the modified ..
- Alcohol & Antiretrovirals in HIV Infection, Oxidative Stress and Liver DiseaseMarianna K Baum; Fiscal Year: 2010..Hepatocellular injury and function will be determined with plasma levels of ALT, AST, platelets, albumin, hyaluronic acid and total and conjugated bilirubin...
- Pontine circuitry regulating REM sleep and atoniaJun Lu; Fiscal Year: 2009..In this flip-flop switch arrangement, GABAergic REM-on neurons (located in the sublateraldorsal tegmental nucleus (SLD)) inhibit GABAergic REM-off neurons (located in the ventrolateral periaqueductal gray matter (vlPAG) and lateral ..
- Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of CholeraJOHN JOSEPH MEKALANOS; Fiscal Year: 2010..We will apply a new method we developed called AST to monitor and study the nature of "conditionally viable environmental cells (CVEC)" of pathogenic V...
- Nonalcoholic fatty liver disease in Hispanic obese youthNancy Butte; Fiscal Year: 2005..and hyperleptinemia, and elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). 3...


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Long term memory (LTM)
is vast. As far as we know capacity has never been reached, but
don't worry the term is still young! However, it's unlikely that
you've ever heard anyone complain that they need to delete a few
memories before they can store anything new! As far as I'm aware
nobody has tried to estimate capacity, but Solso (1991) compares it
favourably with the largest computers.
A Stunning
factoid for you to contemplate. In 1973 Petr Anokhin of Moscow
University wrote:
"We can show
that each of the 10 billion neurons in the human brain has the
possibility of connections to 1 with 28 noughts after it; that's
10,000,000,000,000,000,000,000,000,000 connections! It means that
the total combinations in the brain, if written out, would be 1
followed by 10.5 kilometres of noughts!
One way
psychologists have studied memory is to experiment on themselves.
The beautifully named Marigold Linton kept a detailed diary
recording daily events and facts about flowers etc on cue cards over
many years. Each day was represented by a single word. When given
the cue word she was able to recall with 70% accuracy all the events
and information recorded for that day even 7 years later.
Bahrick et al
Year Book study (1975)
374 participants
aged between 17 and 74 were tested on their memory of school
friends. A number of different tests were carried out including a
free recall of all the names of classmates they could remember,
recognition of classmates from a selection of 50 photographs, a name
recognition test and a photo matching test.
In order to
check accuracy of recall the researchers used year books for the
relevant year groups of the participants.
For participants
that had left school up to 34 years previously, accuracy of recall
on the face and name recognition tasks was still an amazing 90%.
Even for participants who had left school 48 years previously it was
Recall can be
accurate over a very long period of time, leading to the term vLTM
(very long term memory) to describe this phenomenon.
The procedure
used is a field experiment so is much higher in ecological validity
since this is far more similar to the purpose we generally use our
memories for.
However, the
study was poorly controlled. The researchers assumed that last
contact with their classmates would have been when they left
school. Little consideration seems to have been made of
participants seeing classmates in the intervening years or even of
them having looked through yearbooks themselves!
Only one type of
recall (visual) was tested. It could even be argued that
recognition of this sort is not recall as such anyway!
This is a favourite on examination papers. Clearly you could talk about
research into the two main memory stores mentioned above. In addition
to this it would be essential to mention some, if not all, of the
Multistore model of
Discussed in the next section, this would be a good start to the essay
since it suggests how the two main stores work in conjunction with one
Primacy and
recency effect.
Murdock (1962)
gave 103 psychology students lists of words to free recall (in any
order) in 90 seconds. Typically words at the start of the list and
especially those at the end tended to be recalled most often. This was
explained by words at the start being rehearsed from STM into LTM
creating a stronger trace and those at the end still being present in
STM when recall begins. Evidence for two separate stores.
Amnesiac case
Most people with
memory problems have either impairment of their STM or LTM, not usually
both. This suggests that they are different systems.
HM (or Henry
The classic case
is that of H.M who at the age of 27 underwent surgery in an attempt to
cure his epilepsy apparently triggered by a cycling accident when he was
nine. A surgeon, William Scoville removed both his temporal lobes
including a structure known as the hippocampus (Latin for sea horse) and
an area known to be crucial to memory.
Following the
procedure HM was unable to create new long term memories (anterograde
amnesia) and lost some of his existing LTM retrograde amnesia). However
his STM remained intact with a normal capacity and duration, limited
only by his inability to rehearse.
HM is still alive
today, now in his early eighties and being cared for in a residential
home in Connecticut (Wikipedia) he is still being studied by cognitive
psychologists! HM's pattern of
memory loss is not unusual. Clive Wearing suffered a similar form of
amnesia following a herpes simplex (cold sore) infection that spread to
areas of his temporal lobes.
Interestingly in
both cases and in most cases of amnesia affecting LTM it is mainly
episodic memory that is lost, the ability to recall memories of events
and certain factual information such as faces, dates etc. So called
semantic memory is largely unaffected so patients can still use
language, walk, cycle etc. and still retain an understanding of 'how
things work.'
HM therefore
could be taught new skills, which over time would improve with
practice. However, he would have no recollection of ever having
performed them before!
KF who suffered
damage to his STM following a motorcycling accident still retained a
near normal LTM. However, yet again the situation wasn't quite that
simple since KF could still recall visual information using his STM but
struggled with auditory and verbal information, making conversation
What amnesiacs
tell us about memory
We therefore have
a situation were cases of amnesia can both support the idea of two
memory stores whilst at the same time question the idea. This is
particularly good stuff to include in a discussion of the existence of
two memory stores.
Two memory stores
Amnesiacs tend to lose only one store
(either STM or LTM) supporting the idea of two separate stores
presumably located in different brain areas or structures.
More than two stores
However, HM and Clive Wearing both
provide us with evidence that LTM is more complex and seems to comprise
at least two components (semantic and episodic LTM). More on this
when we look at types of LTM. Similarly KF suggests that STM is
also more complicated having separate stores for both auditory and
visual information. See later section on working memory.
Working memory
This is explained
in later sections and argues that STM may not be just one store but a
collection of components each with a different task. This would be
evidence for there being more than two stores.
Brain areas
Modern scanning
techniques have found that different areas of the brain operate when
different stores are being used providing best evidence for different
memory types. The prefrontal cortex is active when STM (now more
correctly referred to as working memory) is being used whereas the
hippocampus in the temporal lobes is active for LTM.
areas known to be involved in LTM
Types of Long term memory
First a note of
caution. 'Types of long term memory' is not specifically mentioned in
the specification, nor do some of the texts, e.g. Cardwell for AS cover
the topic. However, some texts, including ours, do and the wording in
the specification is sufficiently woolly to allow a question on it. To
date no questions have been set on the topic, however, information
contained in this section and covered in class will at the very least be
useful in part c questions that deal with STM and LTM.
saw in the videos on amnesia that many patients suffering memory loss
still have vital aspects of their LTM intact. It is very rare for
amnesiacs to lose their memory for skills such as language (reading and
writing) and for walking, swimming etc. As we saw in the case of Clive
Wearing his ability to play the piano and conduct choirs was still
intact despite most other memories having been lost. In the video his
long suffering wife says that his episodic memory is severely
impaired whilst his semantic memory is largely intact. This is
one way of distinguishing types of LTM, however, there are others: What
follows is a brief summary of these, with examples and similarities
drawn between them.
Episodic and
Semantic (Tulving 1972)
Research evidence:
(1989) using radioactive gold, found different areas of the brain are
active when the two memory types are being used. Episodic engages the
frontal lobes, semantic the posterior lobes.
Declarative and
Procedural (Cohen and squire 1980)
Research evidence:
Squire et al
(1992) used PET scans to show that different areas of the brain were
active during each memory type.
Implicit and
Explicit (Graf and Schacter 1985)
is particularly useful in explaining amnesia in brain-damaged patients,
typically these having damage to their explicit memory but retaining an
intact implicit memory. (E.g. H.M. and Clive Wearing).
Wearing and wife Deborah
Next page

subset: commoncrawl


text:
Late last year, I wrote about why your meeting marketing strategy shouldn't go totally paperless. It's an approach that deserves revisiting now that the United States Postal Service has announced it will no longer deliver mail on Saturdays beginning in August. While your promotional postcards, registration brochures and other marketing materials will still find their way into mailboxes, they will have one less day each week to do so.
Here's a look at how the continuing financial struggles of the USPS may impact your meeting marketing in the future.
1) Postage Costs May Increase.
Can mail continue to be so cheap? Probably not.
"By moving forward with the accelerated cost-cutting actions directed by our Board of Governors, we will continue to become more efficient and come closer to achieving long-term financial stability," Patrick Donahoe, Postmaster General and CEO, USPS, said in a statement.
The USPS may continue to cut costs, but it seems clear that the organization will need to consider raising rates, too. Reaching that goal of long-term financial stability with 46-cent stamps for letters and 33-cent stamps for postcards seems like a real challenge. Be sure to be on the lookout for potential rate increases. While an increase of a few cents may seem small, those adjustments can have a big impact on a mass mailing.
2) Mailboxes Will Be More Clogged.
A reduction in delivery days translates to overstuffed mailboxes.
In the existing delivery model, your prospective attendees receive an average of 2 direct mail pieces each day. Without Saturday on the schedule, your piece may be competing with more messages. That increase in competition puts extra pressure on your creative team to ensure that direct mail from your organization has a must-read appeal that increases brand recognition.
3) Delivery May Slow Down.
While the Postal Service prides itself on delivering in rain or snow, it's important to recognize that cost-cutting measures may impact the organization's ability to deliver your meeting materials on time - - regardless of the weather. As the USPS continues to identify ways to reduce some of its overhead expenses, what used to take a few days may take even longer. Translation: you may want to consider putting those save-the-date postcards in the mail a bit sooner this year.
4) Data is More Valuable Than Ever.
As your marketing strategy continues to leverage direct mail, email, social media and print advertising, it's crucial that you track how each channel is performing.
"With promotional codes for printed pieces and click rates for online messages, data is your best friend," Mary Reynolds Kane, director, online marketing, PCMA says. "Meeting marketers can track which subject lines and messages are opened and clicked on and which codes are entered online in the registration process."
"Direct mail can be a huge item in your marketing budget, so you have to understand whether those high costs are truly paying off with higher registration numbers," Reynolds Kane adds.
For tips on how to make direct mail inspire your audience, click here for advice from the USPS.
Please log in to post comments.
A new survey shows that many Americans are failing to take advantage of this big benefit. Do you fall into this category?
Bill Gates, Justin Timberlake, Taylor Swift, Jimmy Fallon - it seems like all the big names are dumping buckets of ice water over their heads. Did you know the trend is all tied to a non-profit association fundraiser?
All those education sessions and expert speakers represent more than three or four days of on-site learning. Find out how your organization should leverage your education sessions after the meeting ends.
Struggling with subpar open and click-through rates in your meeting marketing email campaign? A new study shines a light on some small adjustments that can make a big impact on inboxes.
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Chicago, Illinois
877.827.7262 (toll-free)
Fax: 312.423.7222
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text:
It took only moments for social media storm to erupt after North Korean state television reported that North Korean dictator Kim Jon signed an order to put the nation's rockets on state-run media.
According to a FOXNews.com web report "a chart titled U.S. mainland strike plan could be seen and a map showed missiles arcing into Hawaii, Washington, Los Angeles and Austin."
On twitter the response from Austinites was fast. #whyaustin hashtag existed before with random posts about life in Austin, but Friday morning it was a non stop buzz of very funny responses on why their beloved Hill Country city was a target.
Austin is home to U.S. strategic BBQ reserves. RT @dblanchard: He just wanted some brisket. #whyaustin #sxdprk twitter.com/dblanchard/sta…— Paul Szoldra (@PaulSzoldra) March 29, 2013
Kim Jong Un didn't get into @jtimberlake secret show at #SXSW #whyaustin— Tejal Patel (@newscommander21) March 29, 2013
And now Austin, I finally get my revenge for the great allergy attack of 2012. foxnews.com/politics/2013/… #whyaustin— John-Henry Perera (@pererajh) March 29, 2013
Because Austin's smugness about its 5.4% unemployment rate has grated on Kim Jong-un's last nerve. twc.state.tx.us/news/press/201…. #whyaustin— Will Franklin (@WILLisms) March 29, 2013
RSVPing for a SXSW event and STILL not getting in? #whyaustin— Scott Corbin (@scottacorbin) March 29, 2013
Kim Jong Un wants to corner the "Pyongyang porridge" food truck market. #whyaustin— Miguel Montanez Jr. (@DigitalMig) March 29, 2013
Austin is on Kim Jong-Un's shortlist of cities to nuke. The man hates hipsters, clearly. #whyaustin— A24 (@A24Films) March 29, 2013
Well someone's bitter about not getting into UT... #whyaustin— Haley Spotts (@haleyspotts) March 29, 2013
Only a town full of hipsters would respond to a bomb threat with a hashtag #whyaustin— Becca Aaronson (@becca_aa) March 29, 2013


text:
Derek Harding | March 12, 2014 | Comments
In a recent change, Gmail has started supporting cache control, a mechanism for websites to indicate how long it's OK to keep content for without requesting an update. While this change does not address all of the capabilities that caching impacted, it does improve the situation for some of them.
I wrote late last year about changes to how Gmail handles images and the impact for marketers. My thanks to Jordan Cohen of Movable Ink for a heads up on a more recent change.
You may recall that Gmail started caching images in emails and doing so in a way that had a number of negative impacts for marketing messages, including loss of location, referrer, browser identification, cookies, timing, and total counts. These losses were mitigated by Gmail's subsequent decision to load images by default, thereby increasing counts and improving how most marketing messages looked.
In a recent change, Gmail has started supporting cache control, a mechanism for websites to indicate how long it's OK to keep content for without requesting an update. While this change does not address all of the capabilities that caching impacted, it does improve the situation for some of them. This is most important to companies that are dynamically serving image content, such as Movable Ink and LiveIntent.
One might reasonably wonder why the Google cache didn't support cache control in the first place. Web caching has a bit of a checkered history and many websites effectively discourage caching of all their content, thereby undermining the reliability of cache control instructions. It's also possible the Google developers were just being lazy - their original problem didn't require cache control so they never implemented support for it. Whatever the reason, they have relented and now support the cache control header.
This means that suitably configured image servers will be able to ensure that every email open results in a new image being served. This is great if you wish to:
What has not changed are all the other things we lost when the cache was introduced. Gmail still hides:
The net result is that of the six pieces of data we originally lost, this change gives back two (timing and counts) but not the others. I do not expect to see the other four pieces of data coming back, ever. Though they have legitimate value and uses, each of them can also be used by nefarious actors to undermine privacy and in some cases security.
As a marketer, if you see a jump in your Gmail open rates, it does not mean you've found some great content, rather than Gmail's total open rates are being recorded again. Which is good news, kind of.
Until next time.
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New Iberia is creeping up to the end of its fiscal year. And with a $2 million budget deficit they are scrambling to find new revenue streams including looking at their existing properties to possibly sell. New Iberia owns more than a 100 acres of land at the Port of Iberia which would provide a steady revenue stream for the city; except for the fact their leasing it out to the port for only $1 a year.
"That was back when the port had nothing and the land was doing nothing so we gave it to the Port of Iberia to make it more attractive for businesses to come, but it's 99 years we tied into a lease right now. We're trying to negotiate to see if the city can get some dollars," said Council member Dan Doerle.
But the original lease agreement was signed back in 1948, so the city still has 34 more years to go, which doesn't help their $2 million budget deficit this year.
"I think the mayor and the port director might be talking to see what can be done to help the city at this time," said Councilman Doerle.
Mayor Hilda Curry confirms that talks with the port are going on, but says "They are going nowhere" and she wouldn't say any more than that. Port Director Roy Pontiff says he's open to an agreement with conditions.
"It's in the port's interest to have a conversation with the city in regards to the lease. If we can negotiate a more permanent arrangement so that we have a little more stability 34 years from now to when the lease is," said Port Director Roy Pontiff.
Councilman Doerle says re-negotiating the lease could be a complicated process. "There's probably a bunch of financial situations that's entailed in that and some legal issues because they did some improvements."
Pontiff says those improvements add up to tens of millions of dollars.
"It was raw, undeveloped probably sugar cane land that value goes up. Like I said probably $8,000-10,000 an acre once we dig the slips and improve the property build bulk heads and stabilize the property with limestone."
Until a final agreement is drawn up, it is unclear how much the city could make but it could be in the hundreds of thousands a year.
"We probably have seven to eight tenants on the city's property and today generate about $600,000 a year in revenues," said Pontiff. But those are revenues the port also depends upon.
"The port is not tax supported. We don't have ad valorem or a sales tax that comes from the city so we generate or revenue by developing property and leasing that property." said Pontiff.
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Route Guide - iPhone / Android - Partners - Forum - Photos - Deals - What's New - School of Rock
Routes Sorted
L to R R to L Alpha
This climb is the bolted face climb in-between "Sky Pilot" (around the corner to right) and the splitter third pitch of "Next" (on the face immediately to the left). Start on the bomber ledge and take the thin horizontal seam out right. Place some small gear, notice the wild exposure, and go up the steep face. This climb is well protected by Donner standards, but it will feel a little more run because of a couple hard clips. Bolts were drilled on on lead, sometimes off hooks. A cool climb and must do if you are in that area of the wall. This climb is not "jingus" : )
Small cams, bolts.


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DALLAS — The Metro Dallas Homeless Alliance thinks it can end chronic homelessness in Dallas in the next three years.
On Tuesday, the head of the organization asked city leaders to support a plan that adds more housing and mental health support for disabled people who are homeless.
MDHA wants to develop 1,800 more apartments by 2015 as well as to offer more support for people with mental illness and addictions so they don't become homeless in the first place.


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New division names were released earlier this week and it has finally set in to me that we're no longer part of the "SouthLeast". I'll miss the division personally, but I could be alone on that since I still sometimes miss having Atlanta and the Technicolor Thrashers visit. However, change is good and this should be very good for the Canes in my opinion. The team should experience more revenue from increased ticket sales due to more attractive divisional opponents and we get the chance to see every Western team each season. In addition to the attendance bump, being in the same division as a number of the larger markets should also raise our profile.
Having said that, there is no getting around the fact that the Hurricanes path to the playoffs just got tougher. As I read reactions from a number of fans from around the league one thing is apparent - most fanbases seem to think their new division is the toughest.
The question I pose is this: Which division going forward is the toughest from top to bottom, the hardest night-in and night-out and why. The more I've thought about the new divisional alignment, the more I have trouble picking a bad division. I lean towards the Pacific being the toughest as you have five really good teams. If the Oilers finally put it together on the ice then you have a really stacked division.


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From the River Rats:
ALBANY, NY—The Albany River Rats are proud to announce that Matthew Pistilli has been named the team's winner of the American Specialty/AHL Man Of The Year award for his outstanding contributions to the Albany community during the 2009-10 season.
Pistilli was the first player this season to participate in the River Rats MVP Health Care "KidPower at School" assembly program, designed to teach school age children the importance of making healthy lifestyle choices and keeping active through sports. The Montreal, QC., native quickly took the health and fitness talk under his wing, volunteering at seven more schools throughout the season and developing his own unique presentation style to keep his audiences of 200-500 students attentive and involved.
In addition to his patented health talks, Pistilli further demonstrated his commitment to the Capital District community by accompanying "Rowdy" the Rat on several visits to the children's ward at Albany Medical Center, by visiting the Ronald McDonald House of Albany, and by handing out presents during the Holidays to underprivileged youth at the St. Ann Institute in Albany.
In recognition of his efforts, Pistilli will be presented with an etched crystal trophy during an on-ice presentation prior to an upcoming River Rats home game.
Pistilli is now one of 29 finalists for the AHL's 2009-10 Yanick Dupre Memorial Award, honoring the overall American Specialty/AHL Man of the Year. The league award is named after the former Hershey Bears forward and AHL All-Star who died in 1997 following a 16-month battle with leukemia. The winner of the Yanick Dupre Memorial Award will be announced by the American Hockey League in the coming weeks.


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Old Rittenhouse Inn "Bayfield Blog"
Kayaking Lake Superior and the Apostle Islands
Kayaking the Apostle Islands Sea Kayaking is one of the best ways to get out among the Apostle Islands in Lake Superior. There are several area outfitters who can put you onto some world class kayaking between May and September. If you've never been to the Inland Sea Caves north of Bayfield, (also known as "the ice Caves" when the area freezes in winter) one of the best ways to get up close is via kayak. There are several caves in which, on a calm day, you can paddle right through the caves to daylight on the other side! Old Rittenhouse Inn offers a specialRead More »
A New Cookbook for the Old Rittenhouse Inn
New Cookbook Arrives in July Here at the Inn, the excitement is building for the impending release of our new cookbook! After nearly two years of hard work, The Old Rittenhouse Inn Cookbook: Meals and Memories from the Historic Bayfield B&B will soon arrive. The book is a cooking tool and a souvenir highlighting the Bayfield area and the Inn itself. As you'd expect, our favorite recipes are featured: breakfast dishes, appetizers, soups, salads, sorbet, entrees and side dishes, desserts and cocktails. In addition, readers will also discover the "inn-sider" history of the Old Rittenhouse Inn as well as many funnyRead More »
The Wilderness Act: A Wisconsin Retrospective
By Guest Blogger Mike Link On April 9 I stayed at the Rittenhouse to deliver an address at the Northern Great Lakes Visitor Center on the 50th anniversary of the Wilderness Act. This is a very significant legislative action which, like the Endangered Species Act, recognized the value of life beyond the human species. Periodically we rise above the acts of normal law to do something that sets an example for the world – Abraham Lincoln setting aside Yosemite in the midst of war, U. S. Grant giving protection to Yellowstone. These are the kinds of acts that truly allow us to rise above theRead More »
Easter Sunday Brunch at Old Rittenhouse Inn
Don't forget our Easter Sunday Brunch at the Landmark Restaurant is just around the corner - April 20th. Reserved seating is available from 10am to 2pm. Brunch at our Bayfield, WI restaurant includes three courses: 2 starters (choice of fruit or salad), 4 entrees, and a variety of desserts. See Menu below for details. Coffee, tea, or juice, plus fresh bakery and preserves is included for $24.50/person plus tax and gratuity. Kids 10-years and under are $16. Get your reservations soon- we are one of the few Bayfield restaurants open Easter Sunday! (715) 779-5112 Landmark Restaurant open Easter Sunday Landmark Restaurant is also open forRead More »
April 11-12: Red Wine Weekend at Old Rittenhouse Inn
Get ready for our upcoming 20th Annual Red Wine Weekend on April 11th and 12th. It's our chance to share and enjoy fine wines, delicious food, and exceptional lodging in Bayfield WI. Wine Weekend events are held at Old Rittenhouse Inn's Le Chateau property, and at the historic Landmark Restaurant at Old Rittenhouse Inn. The highlight of the weekend is a 6-course Red Wine Dinner with Pinot Noirs specially selected to match each dish by the weekend's guest host, Gary Binter. This Wisconsin wine tasting weekend promises to be one of the best ever, as Gary unleashes a virtual tidal wave of big, bold reds,Read More »


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Powered by a live PTO, the FP5's electrically heated 5.1-cu.-yd. hopper keeps asphalt pliable without the potential safety hazards associated with propane or heating oil. An indirect electric-heating band evenly warms tack coating without damaging emulsion; the self-cleaning tack wand minimizes clogging. The operator accesses all components from the back or curbside without stepping into traffic; to avert back strain, a hydraulic lift platform raises and lowers the pavement breaker and plate compactor (or optional single-drum roller). The material chute can be replaced with an optional swing auger system.
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text:
A Generalist-Eclectic Approach, Second Edition
Nick Coady, PhD (Editor)Peter Lehmann, PhD, LCSW
Pub. Date: 10/2007
576 pp.,
Series: Springer Series on Social Work
Available: Usually ships within 48 hours.
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"Finally, a social work practice text that makes a difference! This is the book that you have wished for but could never find. Although similar to texts that cover a range of practice theories and approaches to clinical practice, this book clearly has a social work frame of reference and a social work identity."
--Gayla Rogers, Dean of the Faculty of Social Work, University of Calgary
The major focus of this second edition is the same; to provide an overview of theories, models, and therapies for direct social work practice, including systems theory, attachment theory, cognitive-behavioral theory, narrative therapy, solution-focused therapy, the crisis intervention model, and many more. However, this popular textbook goes beyond a mere survey of such theories. It also provides a framework for integrating the use of each theory with central social work principles and values, as well as with the artistic elements of practice.
Grief Counseling and Grief Therapy, Fourth Edition,
J. William Worden, PhD, ABPP
Cognitive Behavior Therapy in Clinical Social Work Practice,
Tammie Ronen, PhD
Eye Movement Desensitization and Reprocessing (EMDR) Scripted Protocols,
Marilyn Luber, PhD
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Stayed there in a self catering appartment last week of March 2014. Rip off charges for wifi and TV. 25 Euros for one weeks wifi per device..... 20 Euros for TV channels however you did get BBC News 24 for free. 20 Euros for safty deposit box. No kettle, no toaster and maid service consisted of emptying the bins and... More
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text:
The owner of a Fairfield County kennel owner accused of animal abuse has turned himself in to the Fairfield County Municipal Courthouse Wednesday morning.
Cory was wanted for 70 misdemeanor charges, including 22 counts of cruelty to animals, 15 counts of abandoning animals and prohibitions companion animals.
On March 10, Deputies received reports of unsanitary conditions and suspected abuse at Dewberry's kennel, Dewberry Family K-9, located at 9280 Carroll-Northern Rd. in Pickerington.
A search warrant was executed after an Akron dog owner returned to find her German shepherd, Wolfgang, severely under weight.
During the search on March 15, deputies found that the kennel was not in compliance with current licensing and permits. Deputies reported the kennel conditions were unsanitary, and the dogs appeared to be neglected.
Six dogs were seized by the Fairfield County dog warden and the remaining dogs were picked up by their owners.
A seventh dog, owned by Dewberry, remains at the humane society.
"It is not acceptable to mistreat animals and we will investigate and when we see criminal acts, we will file criminal charges," Fairfield County Sheriff Dave Phalen said.
Cory walked into the courthouse at 9 a.m. Wednesday to turn himself in. He was accompanied by an attorney and was arraigned.
"People love their pets and don't want animals mistreated, and we are glad this guy turned himself in and is answering those charges," Phalen said.
He has been released on his own recognizance.
First-degree misdemeanors are punishable by up to a $1,000 fine and six months in jail, with second-degree misdemeanors punishable by up to a $500 fine and three months in jail.
3165 Olentangy River RoadColumbus, OH 43202
Telephone: 614.263.4444
Fax: 614.263.0166
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text:
Remember Me
While most of the country stood watch this week, Casey Anthony was found not guilty of pretty much everything.She was found guilty of lying to police officers. Whoopdedoo. A lot of people have lied to an officer. "I didn't know I was going that fast." "I didn't see the stop sign." "No, I didn't put my seat belt on as you were walking up to my car."
My husband and I (OK, really just my husband) have followed the case from the time little Caylee went missing more than 3 years ago. Nancy Grace is a staple on the TV in the bedroom, the one most watched by my hubby. I personally can't stand her and would rather have two forks stuck in my eye than watch her. To me, her voice is like two cats fighting. She also seems a BIT biased at times. She fits right in on HLN News and Views. For me, I want the facts, not someone's opinion. If I want someone's view, I'll ask for it. Otherwise, I want to make up my own mind.I guess that's how the jury felt, too.The familiar mantra — it was like O.J. all over again. The police and prosecution knew something happened to Caylee, they knew Casey knew what it was and was more than likely involved, they just couldn't prove it. They couldn't prove anything. They had no DNA, they had no fingerprints, they had NO CAUSE OF DEATH. I would have been more surprised and concerned if the jury had went for the death penalty. After listening to the trial myself, I couldn't have convicted her on what the prosecution presented.Still, little Caylee paid the price. It will never be known how she died or why.So on July 17, Casey will be free and able to go about her life — such that it will be.Anti-Casey web sites, Twitter and Facebook pages fill the Internet. I can't imagine it will be easy. I don't want it to be. Even if she did nothing wrong, she still waited 31 days to report her daughter missing. 31 DAYS!!!! Who does that? What kind of mother does that?Children die in accidents all the time. Harried parents forget their infant is in the back seat because they don't normally take the child to daycare. Little ones wander off because they can't be watched 24/7. Children get hurt, drown in swimming pools, get lost — it happens. But how often do you hear of the parent keeping it to themselves for 31 days?They should have at least convicted her of a "what-the-heck" offense.Overall, our justice system works. Defendants get their day in court, the prosecution has the burden of proof and a jury of their peers decides their fate. It's not perfect. Some of the guilty go free and the innocent are sometimes convicted. But, in the long haul, it works.When it doesn't, people like Casey go free. I'm going to keep watching to see what happens next. I want to know just how hard it will be for Casey to resume her "party" life. I think karma will give Casey a little justice down the line. She usually does, we just have to be patient.I just won't be watching it with Nancy Grace. Screeeeeech.
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The Gold Report: Goldman Sachs recently downgraded its 2013 gold forecast from an average of $1,800/ounces ($1,800/oz) to $1,610/oz due to interest rates rising in the U.S. Could this bearish sentiment actually be bullish for gold?
Joachim Berlenbach: I think the report was very one sided. Focusing solely on the U.S. interest rates does not provide a full picture. I would have liked to see a balanced look at where the real demand is coming from. If the report had said, for example, how much gold the Chinese central bank is actually buying compared to its reported purchases, it would have been a much … [visit site to read more]


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This time, St. Peter's didn't have the element of surprise as a weapon.
Instead, top-seeded Cardinal Hayes knew exactly what it was going up against in the Eagles, who handed the state's former top-ranked team its only loss of the season on Feb. 10.
And saying the Cardinals played with a sense of urgency Saturday would be an understatement.
Hayes rode the all-around play of center Nathan Ekwu (15 points, 15 rebounds) and Shavar Newkirk (15 points, nine rebounds) to a halftime double-digit lead and rolled to a 70-50 CHSAA New York Archdiocesan championship game victory over the No. 2 Eagles at Mount St. Michael in the Bronx.
The 26-3 Eagles, who played in their first Archdiocesan final since the 1982-83 season, enter the Intersectional playoffs as the Archdiocese's No. 2 seed. By reaching Saturday's final, they automatically landed a spot in the Intersectional quarterfinals and will meet the Archbishop Molloy-Fordham Prep winner March 2 at Fordham University in the Bronx (time TBA).
St. Peter's coach Charlie Driscoll said the Cardinals obviously wanted to keep their unbeaten streak alive when the teams met for the first time at Hayes nearly two weeks ago, but did notice a difference in urgency this time around.
"They obviously wanted to win (the Archdiocesan title) and although they definitely played hard the last time, they seemed to play (with a bit more intensity) this time,'' said Driscoll, whose team was outrebounded 49-29. "I also think the bigger court helped them. They were able to space things out more than when we played them on their court, which is not very big at all.''
Unlike the first time, when the Cardinals mixed defenses between man-to-man and a 3-2 zone, they exclusively went man from start to finish with an eye toward keeping the ball out of ever-dangerous point guard Glenn Sanabria's hands as often as possible.
"We expected them to come out hard and I thought they did a great job taking me out of the offense,'' said Sanabria, who still finished with a team-high 18 points. "It's my job to get us into our offense and although we fought to the end, we weren't getting into (our offense) the way we normally do and we weren't getting many good shots.''
"They affected what we like to do on offense, which we run through Glenn,'' added Driscoll, whose team committed just five turnovers. "We were starting (our half-court sets) much further out than we normally do; we were settling (for certain shots) instead of waiting for a better shot and we weren't getting any second shots.
"And that was putting more pressure on us to hit (our first) shots.''
SP's opened the scoring with a Walsh 3-pointer 51 seconds into the game, but Hayes responded by scoring the next 12 points, including 3-pointers by Newkirk and Jamal Smith (10 points).
Walsh broke the spell by hitting 1 of 2 freebies with 2:16 left in the quarter, but Smith buried another trey and increased Hayes' lead to 15-4 with just under two minutes to play in the opening stanza.
And although Tim Quinlan helped make it 15-10 by sandwiching buckets around a Tyler Peana jumper in the final 1:46, the Eagles had to contest Hayes' 3-point shooters while trying to keep the bigger Cardinals ... namely the 6-foot-8 Ekwu ... off the boards at the same time.
Easier said then done. SP limited the Bronx school to one trey in the second, but Ekwu, Mustafa Jones (13 points), Newkirk and reserve center Akintoye Ojo kept many possessions alive with offensive rebounds and Hayes built a 35-24 lead at intermission.
"We fought them, we tried to do the best we could,'' said Sanabria. "They're a very talented team with some big kids.''
St. Peter's, which overcome a 13-point, third-quarter deficit to defeat the Cardinals 72-70 in overtime in the regular season, did show signs of like in the third quarter when it opened the second half with a 6-2 run, including a Jamir Ferebee drive and Sanabria 3-pointer. The burst cut the Eagles deficit to seven (37-30) and had Hayes coach Joe Lods signaling for time.
It was still 39-31 after Latrell Curtis hit a free throw with 3:13 left, but the Cardinals exploded for eight straight points behind Ekwu (tip-in), Newkirk, Clive Allen (fast-break layups) and Smith (drive) to up the lead back to 47-31 with under a minute to play.
"Sure we felt we could still do something when we cut it to seven,'' said Driscoll. "But eventually, they responded by hitting a few shots to increase their lead again.
"Unfortunately, it just wasn't meant to (today).''
The Eagles got a David Adeoso three at the end of the third and a Ferebee trey to open the fourth to cut Hayes' lead to 47-37 in the first minute of the fourth, but the Cardinals added three more treys (two by Chris Robinson) and hit 10 of 14 free throws in the final stanza to solidify the title.
"We're still confident,'' said Sanabria, who is looking forward to the Intersectional round. "We know we can play better than we did today and we'll be ready (for our next game).''
NOTES: Ferebee (eight points), who's 3-pointer at the overtime buzzer helped SP defeat Hayes in the regular-season game, left late in the fourth with two dislocated fingers on his non-shooting hand (left). He is expected to be ready to play on March 2 ... Quinlan paced the Eagles with six rebounds while Curtis had a team-high five assists ... St. Peter's lost to St. Nicholas of Tolentine in the 1982-83 Archdiocesan final, but responded with wins over Bishop Loughlin (quarterfinals), Monsignor McClancy (semis) and Molloy (title game) to win Staten Island's lone AA Intersectional crown.


text: Ok the heat lost..good for them. I'm sure Spoelstra their coach will get a lot of blame. I think he will stick around another year with the heat. If they don't win it or show improvement next season I think he will be dealt with. It's Riley's reputation on the line. He's a young coach that's pretty good. Yes, he gets out coached at time, but that's part of being a young coach in the league. If this transpires..and I figure Vinny will be here this season..but if we don't improve or make the playoffs..Vinny might be out after this coming season as well. Could Spoelstra be a serious option for our next coach? Would you like this? Thoughts. Probably sounds silly but just something that came to mind. Spoestra is a west coast guy too.


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Download the 2013 Performer Application
Volunteer to Help
To volunteer, please contact one of our volunteer coordinators, and they will assign you to the appropriate committee.
Volunteer Coordinators:
Micah – firstname.lastname@example.com
Kelley - email@example.com
Make a Donation
Donations can be made to help support the Denton Holiday Festival Association. To mail your donation, please download and complete the contribution form and send it to PO Box 2765, Denton, TX 76202.
You can also make a donation online.
Click here to donate now!
Become a Sponsor by Joining the 100/$100 Holiday Club
Want to be a part of Denton's favorite tradition and get exposure for your business? This event is made possible each year with the help of sponsors like you! The first 100 sponsors who pledge $100 will get publicly recognized in the Denton Record-Chronicle. You can also pledge to increase your sponsorship to a higher amount if DHLF reaches its goal of 100/$100 donations.
Become A Vendor
Would you like to be a Vendor at this year's Denton Holiday Lighting Festival? If you do, there are some steps you must go through to get approved. The first step is to complete the Printed Vendor Application by clicking the link (click here) or completing the application online here: Online Vendor Application.


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Alex Collins sings woo pig sooie
Well at least he didn't end up at Miami of Florida or that little school down south. It was also nice to read this little gem: "Collins was rumored to be recommitting to Miami, and his selection signals the continued free fall of the Hurricanes' class. Coach Al Golden may have already lost Army All-American offensive lineman Denver Kirkland after he reportedly offered Kirkland an ultimatum to commit or risk losing his scholarship offer. Now, they've lost out on one of the state's top running backs who was once committed."