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Advocate Health Centers are community-based medical practices that provide a full range of primary care, specialty care, and support services. Each year we care for over 200,000 patients-from newborns to seniors-in 16 locations throughout the city and suburbs. And we don't just serve the community-we're part of it. Our people typically live where they work, they give back to their hometowns, and they take great pride in knowing that they're making a difference in the lives of their neighbors as well as their patients.
We are so serious about patient satisfaction that we survey our patients three different ways to make sure we know what we are doing well and where we have opportunities to improve. Our relationship with Advocate Health Care gives us resources and support that are among the best in the world. Beyond that, our relationship with the communities we serve gives us a career experience that will remind you again and again exactly why you chose health care. You're going to like it here.
We're bringing the best possible care to Chicagoland. Thanks to people like you. Advocate Health Centers offer a full range of primary care services, specialty care, and support services for patients of all ages. At our 16 sites, we deliver care to more than 200,000 people living in 84 Chicago area zip codes. We have more than 175 physicians and close to 1,000 associates. In 2003 alone, Advocate Health Centers received the following rankings in Crain's Chicago Business Largest Physician Groups survey:
We have a variety of successful disease management programs to help our patients manage their care. These programs include extensive health education to help patients with chronic problems such as asthma, diabetes, and congestive heart failure. We also have programs focusing on prevention such as our breast health, childhood immunization, and influenza programs. Through these initiatives, we stress education, prevention, screening, early diagnosis and treatment, careful monitoring of symptoms, and a wide variety of wellness activities.
Convenience is a priority. Our Centers offer evening and weekend hours; as an associate, you too would benefit from our flexible scheduling options. To enhance patient convenience, many of our Centers also provide on-site services such as laboratory, x-ray, and ultrasound. Many Centers also provide specialty medical services, including cardiology, gastroenterology, neurology, orthopedics, and obstetrics-gynecology, to name just a few.
As you can see, Advocate Health Centers have been designed with our patients' care and convenience in mind. We're proud of our Centers, and welcome associates who want to join us in putting our patients first.
Doing more for people is just the way we do things. Start with our patients-we make sure they have the best possible care. That's why at Advocate Health Centers our culture features the most advanced technologies and the latest advances in health care. We also stress teamwork and shared thinking throughout every location. We believe that the best way to meet our goals of providing excellent patient care is to work together. The result is more time with patients-and higher patient satisfaction.
For our associates we offer an extraordinary level of support. From helping you achieve your goals to helping you maintain work/life balance, we're as committed to your success as you are. Flexible scheduling, professional enhancements, and ongoing associate recognition programs are just a few of the ways we ensure that our associates know that their efforts are appreciated. In addition, every quarter we survey our associates to find out what they like and what opportunities we have to improve.
And when it comes to our community, we're involved in every sense of the word. More often than not, our associates are members of the community. So there's a distinct sense of pride that you'll feel every time we make a difference.
Building a career with Advocate Health Centers will give you the chance to share your talent with patients, coworkers, and the community itself. And that's just the beginning. If you're a team player who appreciates the value of workplace communication, then a position at Advocate Health Centers might be a great fit.
Advocate Health Care is an Equal Opportunity Employer


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On Dig Pink Night, the Fayetteville Pirates captured wins in a pair of high school volleyball matches.
In the opening varsity match, Fayetteville beat Valley 2-0, posting scores of 26-24 and 25-22.
Contributors for the Pirates included: Hannah Samples, four kills, one service point and 17 digs; Cassidy Bayes, one kill, six assists, six service points and six digs; Jessica Brown, four kills, six service points, nine digs and one block; Cassie Semple, one kill, two service points and five digs; Maddie Pritt, three kills, eight assists, four service points and four digs; and Emily Akers, 12 service points and four digs.
In the second varsity match of the evening, Fayetteville beat the Woodrow Wilson JV 2-0 with scores of 25-20 and 25-19.
Following are FHS contributors: Samples, three kills, one assist, nine service points and 11 digs; Bayes, two kills, three assists, seven service points and four digs; Brown, four kills, one service point and four digs; Semple, three kills, four service points and six digs; Pritt, one kill, five assists, two service points and one dig; Akers, three service points and one dig; Kathryn Peelish, two kills and two digs; Jenna Roark, three assists and two digs; Malea Browning, two digs; and Ashton McKinney, two digs.
In middle school play, Meadow Bridge won a best-of-three from the Pirates, 25-20, 25-27 and 25-23.
The Fayetteville varsity (13-8-2) plays Tuesday, Oct. 9 at 6 p.m. at home versus Wyoming East.

subset: commoncrawl


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Archivi Blog
Google tests searches that include Calendar, Drive in results
Google has been testing an expanded search that includes Gmail results ever since August, and it's been enough of a hit that the company is swinging for the fences with an expanded test. The new version lets Gmail members find Calendar appointments and Drive files through the autocomplete results in the search box. Visit the main Google page and the results won't be quite as broad, but they'll include both the previous trial's Gmail infromation as well as Drive — thankfully, tucked to the side rather than dominating the main page. Any individual, English-literate Google fans can join the new trial to get early access and find that long lost spreadsheet in the cloud.
Google Sync adds mail server search, appointment confirmation to native iOS apps
Google Sync has pushed Gmail messages, calendar updates, and contacts to iOS since its launch in 2009, but this half-baked solution previously lacked some key functionality. Beginning today, users can finally perform mail server searches and confirm appointment requests from their iPhone, iPad, or iPod touch. This means that you'll be able to search for messages in your entire mailbox, not just for emails stored on your device — a feature that first appeared with iPhone OS 3, but without Google Sync support. You can also respond to calendar invites from withinthe Calendar app. Fancy that! A third update brings support for sending messages from other addresses listed in your Gmail account, though only the first two features worked when we took Sync for a spin this afternoon. (Curiously, Google omitted a "Send Mail as" screenshot on its blog, so this last update may not actually be available yet.) This latest trio of updates is available for both gratis and Google Apps accounts, so head to the source link for set up instructions and the full feature rundown.


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Research Topics
Genomes and Genes
Summary: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications333 found, 100 shown here
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeP Li
Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
Cell 91:479-89. 1997....
- Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney developmentFrank Costantini
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 18:698-712. 2010The two major components of the kidney, the collecting system and the nephron, have different developmental histories...
- New loci associated with kidney function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 42:376-84. 2010Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants...
- Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survivalRaghavan Murugan
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 77:527-35. 2010While sepsis is a leading cause of acute kidney injury in critically ill patients, the relationship between immune response and acute kidney injury in less severely ill patients with infection is not known...
- New insights into epithelial-mesenchymal transition in kidney fibrosisYouhua Liu
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 21:212-22. 2010..However, the degree to which this process contributes to kidney fibrosis remains a matter of intense debate and is likely to be context-dependent...
- Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination SurveyJosef Coresh
Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 41:1-12. 2003..NHANES III) serum creatinine assay provide a basis for estimating the prevalence and distribution of chronic kidney disease (CKD) in the United States using standardized criteria based on estimated glomerular filtration rate (GFR) ..
- Epithelial-mesenchymal transition and its implications for fibrosisRaghu Kalluri
Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
J Clin Invest 112:1776-84. 2003..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
- Assessing kidney function--measured and estimated glomerular filtration rateLesley A Stevens
Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
N Engl J Med 354:2473-83. 2006
- Acute kidney injury, mortality, length of stay, and costs in hospitalized patientsGlenn M Chertow
Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
J Am Soc Nephrol 16:3365-70. 2005The marginal effects of acute kidney injury on in-hospital mortality, length of stay (LOS), and costs have not been well described...
- The Banff 97 working classification of renal allograft pathologyL C Racusen
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Kidney Int 55:713-23. 1999..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
- Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanismsFlorian Tögel
Division of Nephrology, University of Utah, Salt Lake City, UT 84148, USA
Am J Physiol Renal Physiol 289:F31-42. 2005..the outcome through amelioration of inflammatory, vascular, and apoptotic/necrotic manifestations of ischemic kidney injury...
- Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?Wilhelm Kriz
Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
J Clin Invest 121:468-74. 2011..Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.
- Cellular pathophysiology of ischemic acute kidney injuryJoseph V Bonventre
Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Clin Invest 121:4210-21. 2011Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis...
- Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 176:85-97. 2010Understanding the origin of myofibroblasts in kidney is of great interest because these cells are responsible for scar formation in fibrotic kidney disease...
- Evidence that fibroblasts derive from epithelium during tissue fibrosisMasayuki Iwano
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Clin Invest 110:341-50. 2002..Using bone marrow chimeras and transgenic reporter mice, we show here that interstitial kidney fibroblasts derive from two sources...
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in miceMartin C Herzig
Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
Hum Mol Genet 20:4209-23. 2011..knock-out, KO) showed an early-onset (age 6 weeks) marked increase in number and size of secondary lysosomes in kidney proximal tubule cells and lamellar bodies in lung type II cells...
- Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagellaG J Pazour
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Biol 151:709-18. 2000..Mice with defects in Tg737 die shortly after birth from polycystic kidney disease. We show that the primary cilia in the kidney of Tg737 mutant mice are shorter than normal...
- TLR4 activation mediates kidney ischemia/reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
J Clin Invest 117:2847-59. 2007..TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation...
- The classification of glomerulonephritis in systemic lupus erythematosus revisitedJan J Weening
Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
J Am Soc Nephrol 15:241-50. 2004..We hope that this revision, which evolved under the auspices of the International Society of Nephrology and the Renal Pathology Society, will contribute to further advancement of the WHO classification...
- Relation between kidney function, proteinuria, and adverse outcomesBrenda R Hemmelgarn
Department of Medicine, University of Calgary, Calgary, Alberta, Canada
JAMA 303:423-9. 2010The current staging system for chronic kidney disease is based primarily on estimated glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse outcomes...
- Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohortsBrad C Astor
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Kidney Int 79:1331-40. 2011..rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD)...
- Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidneyShinji Kume
Department of Medicine, Shiga University of Medical Science, Japan
J Clin Invest 120:1043-55. 2010..Here, we investigated in mice the mechanisms underlying CR-mediated protection against hypoxia in aged kidney, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-..
- Renal clearance of quantum dotsHak Soo Choi
Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
Nat Biotechnol 25:1165-70. 2007..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
- Chronic kidney disease: the global challengeA Meguid El Nahas
Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
Lancet 365:331-40. 2005The worldwide rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal failure necessitating renal replacement therapy is threatening to reach epidemic proportions over the next decade, and only a ..
- Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failureMarina Morigi
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
J Am Soc Nephrol 15:1794-804. 2004..and displayed binding sites for Lens culinaris lectin, indicating that mesenchymal stem cells engraft the damaged kidney and differentiate into tubular epithelial cells, thereby restoring renal structure and function...
- IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injuryLi Li
Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
J Clin Invest 120:331-42. 2010..The extent to which they contribute to innate immunity is, however, unknown. We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI ..
- Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trialMurray D Esler
Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
Lancet 376:1903-9. 2010..We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of blood pressure in patients with treatment-resistant hypertension...
- Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysisVikas R Dharnidharka
Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
Am J Kidney Dis 40:221-6. 2002..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference...
- Aldosterone: effects on the kidney and cardiovascular systemMarie Briet
Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
Nat Rev Nephrol 6:261-73. 2010..activity, is mainly recognized for its action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the epithelial sodium channel (ENaC)...
- Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approachAlexandre Lautrette
INSERM U426, Hopital Necker Enfants Malades, IFR 94, Universite Paris 5, 149 rue de Sevres, 75015 Paris, France
Nat Med 11:867-74. 2005..These findings indicate a crucial role for AngII-dependent EGFR transactivation in renal deterioration and identify in TACE inhibitors a new therapeutic strategy for preventing progression of chronic renal diseases...
- Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administrationJiangxue Wang
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
Toxicol Lett 168:176-85. 2007..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
- The natural history of chronic allograft nephropathyBrian J Nankivell
Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
N Engl J Med 349:2326-33. 2003With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure.
- Mesenchymal stem cells reside in virtually all post-natal organs and tissuesLindolfo da Silva Meirelles
Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Cell Sci 119:2204-13. 2006..characteristics can be derived and propagated in vitro from different organs and tissues (brain, spleen, liver, kidney, lung, bone marrow, muscle, thymus, pancreas); (2) MSC long-term cultures can be generated from large blood ..
- The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney diseaseHiroyuki Kobori
Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
Pharmacol Rev 59:251-87. 2007..In the kidney, all of the RAS components are present and intrarenal angiotensin II (Ang II) is formed by independent multiple ..
- Identification of a microRNA signature of renal ischemia reperfusion injuryJonathan G Godwin
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:14339-44. 2010..However, overexpression of miR-21 alone was not sufficient to prevent TEC death following ischemia. Our findings therefore define a molecular fingerprint of renal injury and suggest miR-21 may play a role in protecting TEC from death...
- Mitochondria, reactive oxygen species and cadmium toxicity in the kidneyGlenda Gobe
Centre for Kidney Disease Research, University of Queensland School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane 4102, Australia
Toxicol Lett 198:49-55. 2010The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease...
- Distinct macrophage phenotypes contribute to kidney injury and repairSik Lee
Yale University School of Medicine, 333 Cedar Street, PO Box 208029, New Haven, CT 06510, USA
J Am Soc Nephrol 22:317-26. 2011The ischemically injured kidney undergoes tubular cell necrosis and apoptosis, accompanied by an interstitial inflammatory cell infiltrate...
- Update on mechanisms of ischemic acute kidney injuryPrasad Devarajan
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, OH 45229 3039, USA
J Am Soc Nephrol 17:1503-20. 2006
- Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseasesVera Eremina
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Clin Invest 111:707-16. 2003b>Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury...
- A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant miceM Yoshioka
Department of Hygiene, Akita University School of Medicine, Japan
Diabetes 46:887-94. 1997..This locus, which we named Mody4, was mapped to chromosome 7 in a region 2-8 cM distal to D7Mit189 (logarithm of odds [LOD] score = 15.6 and 10.3)...
- Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort studyAnja Haase-Fielitz
Department of Intensive Care, Austin Health, Melbourne, Australia
Crit Care Med 37:553-60. 2009To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function.
- Alport's syndrome, Goodpasture's syndrome, and type IV collagenBilly G Hudson
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
N Engl J Med 348:2543-56. 2003
- Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cellsJeremy S Duffield
Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Invest 115:1743-55. 2005Ischemia causes kidney tubular cell damage and abnormal renal function. The kidney is capable of morphological restoration of tubules and recovery of function...
- Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidneyShuei Liong Lin
Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 173:1617-27. 2008..type I, alpha 1 (coll1a1) promoter and enhancers, we examined the origins of coll1a1-producing cells in the kidney. Here we show that in normal kidney, both podocytes and pericytes generate coll1a1 transcripts as detected by ..
- Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARBMaristela Lika Onozato
Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
Kidney Int 61:186-94. 2002..We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and nitrotyrosine deposition in the kidneys of rats with diabetes mellitus (DM)...
- Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injuryThomas L Nickolas
Columbia University, New York, New York 10032, USA
Ann Intern Med 148:810-9. 2008A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia.
- Apoptosis and acute kidney injuryAndrea Havasi
Renal Section, Department of Medicine, Boston University, Boston, Massachusetts 02118, USA
Kidney Int 80:29-40. 2011Improved mechanistic understanding of renal cell death in acute kidney injury (AKI) has generated new therapeutic targets...
- Obesity-related glomerulopathy: an emerging epidemicN Kambham
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 59:1498-509. 2001..The ten-fold increase in incidence over 15 years suggests a newly emerging epidemic. Heightened physician awareness of this entity is needed to ensure accurate diagnosis and appropriate therapy...
- Regeneration of glomerular podocytes by human renal progenitorsElisa Ronconi
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
J Am Soc Nephrol 20:322-32. 2009..Here, we demonstrate that in the adult human kidney, CD133+CD24+ cells consist of a hierarchical population of progenitors that are arranged in a precise sequence ..
- Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cellsMitsuo Kato
Gonda Diabetes Center, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
J Biol Chem 285:34004-15. 2010..These results demonstrate that post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-β-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy...
- Proposal for diagnostic criteria for IgG4-related kidney diseaseMitsuhiro Kawano
Division of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Japan
Clin Exp Nephrol 15:615-26. 2011..by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target...
- Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trialJianming Tan
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University and Fujian Key Laboratory of Transplant Biology, Fuzhou, China
JAMA 307:1169-77. 2012Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging...
- Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathyHongting Zheng
Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
Diabetes 60:3055-66. 2011..To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy...
- Toward a unified theory of renal progressionRaymond C Harris
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Annu Rev Med 57:365-80. 2006..New knowledge about the cell biology of progression also suggests that other adjunctive therapies may be possible. We describe the progress and highlight those spheres where new-targeted interventions may arise...
- Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidneyK J Jung
Department of Pharmacy, Pusan National University, Busan, Korea
Inflamm Res 58:143-50. 2009To compare the effect of short-term calorie restriction (CR) on aging with that of already known long-term CR, the anti-inflammatory efficacy of 10-day CR was explored in aged rat kidney.
- Structural and functional changes in the kidneys of high-fat diet-induced obese miceNaoko Deji
Dept of Medicine, Shiga Univ of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
Am J Physiol Renal Physiol 296:F118-26. 2009Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear...
- Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)Garabed Eknoyan
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Am J Kidney Dis 42:617-22. 2003
- Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKDPablo E Pergola
Renal Associates, PA, San Antonio, Tex, USA
Am J Nephrol 33:469-76. 2011..Bardoxolone methyl, a novel synthetic triterpenoid, induces Nrf2, a transcription factor known to play a key role in decreasing oxidative stress and the production of pro-inflammatory molecules...
- Renal fibrosis: new insights into the pathogenesis and therapeuticsYouhua Liu
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Kidney Int 69:213-7. 2006..consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease...
- Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injuryDenise W Wong
Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Pathol 171:438-51. 2007..We examined the effect of deletion of the angiotensin-convert-ing enzyme 2 (Ace2) gene on diabetic kidney injury...
- Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injuryFlorian Tögel
Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
Am J Physiol Renal Physiol 292:F1626-35. 2007Acute kidney injury (AKI) is a major clinical problem in which a critical vascular, pathophysiological component is recognized...
- Resolved: EMT produces fibroblasts in the kidneyMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Soc Nephrol 21:1247-53. 2010..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
- Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital systemThomas J Carroll
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Dev Cell 9:283-92. 2005..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
- Modified RIFLE criteria in critically ill children with acute kidney injuryA Akcan-Arikan
Renal Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
Kidney Int 71:1028-35. 2007A classification system has been proposed to standardize the definition of acute kidney injury in adults. These criteria of risk, injury, failure, loss, and end-stage renal disease were given the acronym of RIFLE...
- Stromal cells protect against acute tubular injury via an endocrine effectBaoyuan Bi
Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
J Am Soc Nephrol 18:2486-96. 2007..Using the Y chromosome as a marker of donor stromal cells, examination of multiple kidney sections at one or four days after cell infusion failed to reveal any examples of stromal cells within the tubules,..
- Chronic kidney disease management in the United Kingdom: NEOERICA project resultsP E Stevens
Department of Renal Medicine, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, Kent, UK
Kidney Int 72:92-9. 2007Early identification of patients with chronic kidney disease (CKD) may allow health-care systems to implement interventions aimed at decreasing disease progression and eventual morbidity and mortality...
- Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injuryT Ichimura
Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA
J Biol Chem 273:4135-42. 1998..1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1)...
- Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injuryKiyoshi Mori
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 115:610-21. 2005..In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage...
- Molecular identification of a renal urate anion exchanger that regulates blood urate levelsAtsushi Enomoto
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
Nature 417:447-52. 2002..The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences...
- Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney diseaseHisashi Hasegawa
Innovative Drug Research Laboratories, Kyowa Hakko Kirin, Tokyo, Japan
Kidney Int 78:975-80. 2010Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with early chronic kidney disease (CKD) and are postulated to cause low blood levels of 1,25-dihydroxyvitamin D, as well as normal phosphate levels...
- Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in ratsL L Woods
Division of Nephrology, Oregon Health Sciences University, 3181 S W Sam Jackson Park Rd, Portland, Oregon 97201 3098, U S A
Pediatr Res 49:460-7. 2001..5%, LP) diet throughout gestation. Birth weight was reduced by 13% (p < 0.0005), and the kidney/body weight ratio was reduced in LP pups...
- Multiple loci associated with indices of renal function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 41:712-7. 2009Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity...
- Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in ratsClaudia Lange
Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
Kidney Int 68:1613-7. 2005..The aim of this study was, therefore, to evaluate the therapeutic effectiveness of bone marrow-derived mesenchymal stem cells in a rat model of ischemia/reperfusion (I/R) ARF...
- Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney diseaseAdriana S Dusso
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Kidney Int 79:715-29. 2011In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and skeletal disorders predisposing to renal and ..
- Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segmentKylie Georgas
NHMRC Principal Research Fellow, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
Dev Biol 332:273-86. 2009..form a renal vesicle (RV), the subsequent patterning of the nephron and fusion with the ureteric component of the kidney to form a patent contiguous uriniferous tubule has not been fully characterized...
- Role of mammalian target of rapamycin signaling in compensatory renal hypertrophyJian Kang Chen
Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
J Am Soc Nephrol 16:1384-91. 2005Loss of functioning nephrons stimulates the growth of residual kidney tissue to augment work capacity and maintain normal renal function. This growth largely occurs by hypertrophy rather than from hyperplasia of the remaining nephrons...
- Kidney function is related to cerebral small vessel diseaseM Arfan Ikram
Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Stroke 39:55-61. 2008Poor kidney function, as measured by glomerular filtration rate (GFR), is closely associated with presence of glomerular small vessel disease...
- The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal deathH Putaala
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
Hum Mol Genet 10:1-8. 2001..In the cerebellum, the expression was seen in radial glial cells. Neither anatomical nor morphological abnormalities were observed in the brains of null mice...
- Atlas of gene expression in the developing kidney at microanatomic resolutionEric W Brunskill
Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Dev Cell 15:781-91. 2008b>Kidney development is based on differential cell-type-specific expression of a vast number of genes...
- The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasionJ Comijn
Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
Mol Cell 7:1267-78. 2001..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
- BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterningG Luo
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Genes Dev 9:2808-20. 1995..BMP-7-deficient mice die shortly after birth because of poor kidney development...
- A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eyeA T Dudley
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 9:2795-807. 1995..The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye...
- Aquaporins in the kidney: from molecules to medicineSøren Nielsen
The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
Physiol Rev 82:205-44. 2002..In the kidney, at least seven aquaporins are expressed at distinct sites...
- Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db miceS Ghosh
Dept of Anaesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, Univ of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Am J Physiol Renal Physiol 296:F700-8. 2009..Reductions in caspase-3 and caspase-8 activities, with parallel improvements in SOD expression and reduced oxidative damage, could underlie the beneficial effects of exercise in diabetic kidney disease.
- Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney developmentArindam Majumdar
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 130:3175-85. 2003..ureteric epithelium and the metanephric mesenchyme are needed to drive growth and differentiation of the embryonic kidney to completion...
- TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosisThomas T Chen
Veterans Administration Medical Center, San Francisco, CA 94121, USA
J Exp Med 202:955-65. 2005..immunoglobulin-domain and mucin-domain (TIM) proteins constitute a receptor family that was identified first on kidney and liver cells; recently it was also shown to be expressed on T cells...
- The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potentialHiroyuki Mori
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Biochem Biophys Res Commun 384:471-5. 2009..These results indicate that mTOR activation plays a pivotal role in the development of ESRD and that rapamycin could be an effective therapeutic agent for DN...
- Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney agingHeather E Wheeler
Department of Genetics, Stanford University Medical Center, Stanford, California, USA
PLoS Genet 5:e1000685. 2009..and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for association with kidney aging...
- Aquaporins in kidney pathophysiologyYumi Noda
Department of Nephrology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
Nat Rev Nephrol 6:168-78. 2010..This Review describes recent progress in uncovering the physiology and pathophysiology of aquaporins in the kidney, with particular attention devoted to AQP2, the most well-studied member of this protein group.
- Cellular maintenance and repair of the kidneyJian Kan Guo
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Annu Rev Physiol 72:357-76. 2010The mammalian kidney is a highly complex organ that requires the precise structural arrangement of multiple cell types for effective function...
- Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foodsRecep Cetin
Ankara Oncology Education and Search Hospital, Department of General Surgery, Ankara, Turkey
J Appl Toxicol 26:42-6. 2006..glutathione peroxidase and catalase enzymes, and antioxidant potential value) parameters were measured in kidney tissues of the groups. Histopathological examination was also performed...
- Genetic loci influencing kidney function and chronic kidney diseaseJohn C Chambers
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
Nat Genet 42:373-5. 2010..we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15))...
- Methylation determines fibroblast activation and fibrogenesis in the kidneyWibke Bechtel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:544-50. 2010..of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney. RASAL1 hypermethylation is mediated by the methyltransferase Dnmt1 in renal fibrogenesis, and kidney fibrosis is ..
- Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidneyChun Cheng Hou
Department of Medicine, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Am J Pathol 166:761-71. 2005..We hypothesized that blocking TGF-beta1 signaling could attenuate renal fibrosis in a rat model of remnant kidney disease...
- The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complexChao Ling Yang
Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Invest 117:3403-11. 2007..Previous work showed that WNK1, WNK4, and a kidney-specific isoform of WNK1 interact to regulate NCC activity, suggesting that WNK kinases form a signaling complex...
- Insulin signaling to the glomerular podocyte is critical for normal kidney functionGavin I Welsh
Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK
Cell Metab 12:329-40. 2010..Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function.
- Podocyte biology and response to injuryPeter Mundel
Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
J Am Soc Nephrol 13:3005-15. 2002
- Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatmentK M Park
Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA
J Biol Chem 276:11870-6. 2001..Unilateral ischemia was also protective against a subsequent ischemic insult to the same kidney, revealing that systemic uremia is not necessary for protection...
- Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetesGiuseppe Remuzzi
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
J Clin Invest 116:288-96. 2006The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem...
- The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional studyHiroyuki Ito
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
Cardiovasc Diabetol 9:18. 2010To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the urinary ..
- Roles of interferon-gamma and interleukin-4 in murine lupusS L Peng
Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Clin Invest 99:1936-46. 1997....
Research Grants108 found, 100 shown here
- Fibrotic Sequelae of Childhood Renal DiseaseAgnes Fogo; Fiscal Year: 2007..cardiovascular complications in ch^Jkn with chronic kidney disease, Jabs p^Pbses to test if carotid artery intima media thickness can be used as a surrogate marker for the ..
- NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSChristopher S Wilcox; Fiscal Year: 2010We have found that endothelial dysfunction develops early in human hypertension and chronic kidney disease (CKD). It is accompanied by increased reactive oxygen species (ROS) which can inactivate nitric oxide (NO)...
- BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSELisa Guay Woodford; Fiscal Year: 2003..The cpk mouse was the first polycystic kidney disease (PKD) model to be described and as such, it has been the most extensively characterized...
- Structure and function of urea transportersMing Zhou; Fiscal Year: 2010..UTs are highly expressed in many mammalian tissues, including kidney, liver, and brain...
- Inflammation and T Cell Memory: Inter-related Barriers to Allograft ToleranceTerry Strom; Fiscal Year: 2007..drug toxicity, and malignancies emphasizes the limitations of chronically administered immunosuppression in kidney and islet transplantations...
- Ca2+-Sensing Receptor: Novel Roles in Calcium HomeostasisEdward M Brown; Fiscal Year: 2009..the CaR but also the thyroidal, calcitonin (CT)-secreting C-cells and cells in several nephron segments within the kidney, as well as various other tissues...
- Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with PMarguerite Hatch; Fiscal Year: 2010..of managing two different clinical entities having in common an increased urinary excretion of oxalate leading to kidney stone formation...
- Role of Insulin Receptors in the KidneyCAROLYN MARY ECELBARGER; Fiscal Year: 2010..However, mechanisms underlying these associations are in dire need of clarification. For example, in the kidney, insulin, through its own receptor, can lead to sodium retention, and activate the epithelial sodium channel (ENaC)..
- The Postischemia Inflammatory Syndrome in the Aged KidneyKATHERINE JULIA KELLY; Fiscal Year: 2010Chronic kidney disease (CKD), end stage renal disease and their complications are a public health problem of epidemic proportions...
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 20106. PROJECT SUMMARY/ABSTRACT Most vital organs in the body (Kidney, Intestine, Liver, Lung, Glands) are composed of epithelial cells which carry out the main functions of the organ, necessary for survival of the organism...
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 20096. PROJECT SUMMARY/ABSTRACT Most vital organs in the body (Kidney, Intestine, Liver, Lung, Glands) are composed of epithelial cells which carry out the main functions of the organ, necessary for survival of the organism...
- A Novel Device for Determination of GFR MarkersBikas Vaidya; Fiscal Year: 2007About 20 million Americans have chronic kidney disease while an additional 20 million are at risk. Over the next 10 years, the number of patients in the U.S. with end stage renal disease is expected to double...
- REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSIONPeter Igarashi; Fiscal Year: 1999..this project are to identify the cis-acting regulatory elements and transcription factors that are responsible for kidney-specific gene expression...
- Pathogenesis of Murine Polyomavirus Allograft NephropathyKenneth A Newell; Fiscal Year: 2010..address this problem, we have developed an unique experimental model of polyomavirus infection in mice following kidney transplantation that mimics many of the important features of BKVN in clinical transplantation...
- Microcirculation in Renovascular HypertensionALEJANDRO ROBERTO CHADE; Fiscal Year: 2010..Despite the advances in renal revascularization techniques and stenting, the stenotic kidney often does not improve and even continues to deteriorate after a successful intervention, and the mechanisms ..
- Mast-Cell Renin and Local ANG II FormationRANDI SILVER; Fiscal Year: 2009Progressive kidney disease is characterized by the accumulation of fibrotic mediators in the kidney...
- Polyamine metabolism in heart and kidney ischemic injuryManoocher Soleimani; Fiscal Year: 2005..The pathophysiology of IRI is strikingly similar in heart and kidney, with enhanced production of toxic metabolites (i.e...
- Mast-Cell Renin and Local ANG II FormationRANDI SILVER; Fiscal Year: 2009Progressive kidney disease is characterized by the accumulation of fibrotic mediators in the kidney...
- Eph Kinase Signaling In Renal Epithelial CellsBingcheng Wang; Fiscal Year: 2009..systems that we have established to determine the cellular and molecular bases underlying Eph kinase regulation of kidney development...
- Eph Kinase Signaling In Renal Epithelial CellsBingcheng Wang; Fiscal Year: 2010..systems that we have established to determine the cellular and molecular bases underlying Eph kinase regulation of kidney development...
- Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant RejectionAnupam Agarwal; Fiscal Year: 2007At present approximately 60,000 patients with chronic kidney disease are awaiting a kidney transplant but only 14,000 patients receive a graft each year due to a shortage of donor organs...
- The Aging Kidney in HIV-Infection: biomarkers for early detection of injuryMichael G Shlipak; Fiscal Year: 2010HIV-infected persons are at greater risk of accelerated aging complications, including premature kidney, heart, and bone diseases...
- Disparities in Progression to Renal Replacement TherapyStephen F Derose; Fiscal Year: 2010Chronic kidney disease (CKD) is now recognized as a major public health problem. When the kidneys fail, death inevitably ensues without the aid of dialysis or kidney transplantation...
- Role of Periostin in Polycystic Kidney DiseaseDARREN WALLACE; Fiscal Year: 2009Autosomal dominant polycystic kidney disease (ADPKD) is a hyperplastic disorder in which aberrant growth of tubule epithelial cells causes the formation of numerous fluid-filled cysts, massively enlarged kidneys and progressive loss of ..
- Role of Periostin in Polycystic Kidney DiseaseDarren P Wallace; Fiscal Year: 2010Autosomal dominant polycystic kidney disease (ADPKD) is a hyperplastic disorder in which aberrant growth of tubule epithelial cells causes the formation of numerous fluid-filled cysts, massively enlarged kidneys and progressive loss of ..
- Meprin A Metalloproteinase in Acute Kidney InjuryGUR PRASAD KAUSHAL; Fiscal Year: 2010..metalloendopeptidases of the 'astacin'family, are highly expressed at the brush-border membranes of the kidney proximal tubules. The specific role of meprins during acute kidney injury (AKI) is not fully understood...
- Role of SGLT3 in diabetes-mediated increased renal sodium reabsorptionNiloofar M Tabatabai; Fiscal Year: 2010..b>Kidney expresses SGLT1 and SGLT2 on the apical side of the PT cells...
- The association of lead and cadmium exposure with kidney function in childrenJeffrey Fadrowski; Fiscal Year: 2007To date, factors influencing the rate of decline in kidney function in children are poorly described and understood...
- Understanding Race and Culture in Living Donor Kidney TransplantationLarissa Myaskovsky; Fiscal Year: 2009..are four times as likely as whites to have end stage renal disease (ESRD), but only half as likely to receive kidney transplants, the optimal treatment for ESRD...
- Strategies for ACE2 Amplification to Treat Diabetic Kidney DiseaseDaniel Batlle; Fiscal Year: 2010..coupled with decreased ANG-(1-7) formation owing to ACE2 downregulation may play an important role in diabetic kidney disease...


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JACKSON, MS (WLBT) – A tour bus meeting place turned into the scene of a shooting investigation early Friday morning.
Jackson police were called to the scene just before 1:30 a.m. at the Walmart parking lot on Greenway Drive off Highway 18.
J.P.D. spokesman Sgt. Joseph Daugtry said a man, whose name and age have not been released, was shot and sent to a local hospital.
Witnesses told police a domestic dispute took place on the chartered bus that used the store parking lot as a pick up and drop off point.
The argument between the man and the unidentified shooter escalated into gunfire once they exited the bus.
Daughtry said the victim's injuries are not believed to be life threatening.
No arrests have been made.
©2010 WLBT. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed


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A former Sewickley priest who started a splinter church and was excommunicated from the Roman Catholic Church has died.
C. William Hausen, pastor of Christ Hope Ecumenical Catholic Church in Brighton Heights, died suddenly on Sunday, Feb. 17. He was 77.
In 2004, Hausen started the Christ Hope Church in a rented ballroom at the former Sewickley Country Inn. His excommunication was described as a self-imposed consequence of that act, the Pittsburgh Tribune Review said.
Hausen had previously delivered a controversial Easter homily in 2002 that led to his transfer from St. James Catholic Church in Sewickley to the Sacred Heart Parish in Shadyside.
A priest who knew Hausen wrote in a blog this week that the former priest had struggled for years with alcoholism and sought treatment through Alcoholics Anonymous.
According to the Christ Hope Church website, Hausen served as a priest for the Pittsburgh Catholic Diocese for 40 years during which time he was pastor at the former St. Joseph Parish in Mt. Oliver and also pastor of St. Victor's Parish in Bairdford.
"He was beloved by his family, friends, and parishioners," the church website reads.
Son of late parents Carl and Eileen Hausen, he is survived by sisters Jeanne Worgo, Mary Carol Blewitt, and Janet Feldmeier and brother-laws Ronald Worgo, Bob Blewitt and Curtis Feldmeier.
At Hausen's request, there will be no service or viewing. All arrangements are private. Donations in honor of his memory can be made to Father Martin's Ashley Scholarship Fund, 800 Tydings Lane, Havre de Grace, M.D. 20178 or www.fathermartinashley.com
A memorial for Hausen is planned for 6 p.m. Saturday, March 2 at Christ Hope Church.


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14 - WeakAura Options Loading Very Slowly
What steps will reproduce the problem?
1. Have several (100+) weak auras.
2. Type /wa to bring up the weak aura options.
What is the expected output? What do you see instead?
In the top left corner, there's the text: "Creating Buttons ###/###". For me, usually that is only there for a second or two while it's loading all my auras. However, now it's taking several minutes to get through all the auras. It'll load about 20 auras every 10 seconds. Then it'll freeze on a number and wait the 10 seconds before jumping up to another number about 20 higher. I have 332 auras, so if I need to change anything, it's going to be a several minute wait. I saw this issue in the comments, but I didn't see any tickets about it so I figured I'd put in a ticket to keep track of it easier.
What version of the product are you using?
The latest alpha, r10.
Do you have an error log of what happened?
There's no errors (I run BugStack) and all the auras seem to work correctly. I just can't load old ones or create new ones without a several minute wait.
Please provide any additional information below.
Can't think of anything else useful. Let me know if you need anything more from me. Thanks for all your hard work!
|Oct 10, 2013 at 00:40 UTC


text:
Autodesk ReCap API
The Autodesk ReCap API allows developers to access and integrate the functionality of Autodesk Photoscenes and Autodesk files with other applications. Some example API methods include launching the Photoscene process, retrieving Photoscenes, and adding and managing files.
API Key, OAuth 2
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Related News Articles
AutoDesk Shows How APIs Help Transform Personalized Manufacturing
AutoDesk Shows How APIs Help Transform Personalized Manufacturing
Partnerships between 3-D modeling software provider Autodesk and users of its ReCap API reveal how manufacturing is becoming yet another industry facing major disruption.
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text:
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Round 2 Margus Hunt DE 6'8" 272 DE SMU. This guy is a beast, hes huge, fast, and has the potential to be the best DE in this class. My new pick, Matt Elam SS
Round 3 Larry Warford 6'2" 325 G Kentucky. Man those 3rd and lond and 3 and outs are still bugging me. We have a good back feild with LeSoure and Bell, running the ball will help our team win way more ball games next year. It eats the clock up and keeps our defense off the damn feild. My new pick Travis Fredrick C
Round 4 Levine Toilolo 6'8" 263 TE Stanford. COMP PICK Massive TE here with great hands and like to run block. Think Gronkowski with this dude. Pettigrew sucks imo. I can see us parting ways with him after his contract is up.
Free Agents I would like to see on our team next year.
Michael Johnson DE 6'7" 270
Jairus Byrd S 5'10" 203
Shane Lechlear P 6'2" 220
Danny Amendola WR 5'11" 188
Dominique Rodgers Cromartie CB 6'2 182
I think these guys should be cheap. Let Avril walk, and try to resign the rest of our team. I really think we are alot better than our record shows, and playoffs are in our site. I based this post on feild position. #1 run the damn ball more #2 continuity is key if this team is going to turn things around #3 NO MORE 3rd and long and 3 and outs, god that crap drove me nuts last year.


text:
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The essays in Matt Love's anthology Red Hot and
Rollin' take a lively and nostalgic look at Oregon in 1977,
the year the Portland Trailblazers won their one and only NBA
Julianne Couch says the University of Wyoming
women's basketball team had the whole state cheering as they
became national champions.
Basketball provides a bright spot in reservation life.
The West in your Inbox


text:
Under Armour Men's ColdGear Infrared Thermo Crewneck Long Sleeve ShirtItem Number: 22338896
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When your training takes you outdoors, get unbeatable warmth in the Under Armour® Men's ColdGear® Infrared Thermo Crewneck Shirt. Equipped with ColdGear® Infrared technology to keep you warm without the extra weight, this top is the ideal baselayer. A bonded hex-patterned interior structure traps heat, while four-way stretch construction offers total mobility. For a baselayer as tough as you, get the UA ColdGear® Infrared Shirt
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Rated 4 out of 5�by Jbledsoe20 Great shirts Another great product from under armour. Shirt fits great and they look god as well. Deffinately warm also. I do think they are a bit over priced though February 19, 2014


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The SyrVet Calf Milk Bottle and Fluidfeeder offer two options to deliver milk and nutrients to calves. The 2-qt. milk bottle delivers a full serving of milk at each feeding. An air-release snap-on nipple ensures that a consistent fl ow of milk will reach the sucking calf. The nipple and bottle are made of strong, durable plastic. Replacement nipples are available and are sold separately. The SyrVet Fluidfeeder features a fl exible probe to direct vital nutrients directly to a calf's stomach. This is the recommended procedure for rehydration of stressed cattle and delivering colostrum to weak or sick calves quickly. Easy to clean, the Fluidfeeder's flexible tube is a safe option for calf feeding.
MSRP: Milk Bottle, $4; Fluidfeeder, $11. Contact: SyrVet Inc., P.O. Box 490, Waukee, IA, 50263; (800) 727-5203; www.syrvet.com.
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text:
Richland County Sheriff's deputies have been talking to witnesses who may help them find a man who shot two people in a nightclub early Saturday morning.
Deputy Curtis Wilson said a fight broke out inside Club Crush on River Dr. between 20-30 people at about 3:15 a.m. Saturday. After club security ejected everyone involved, Wilson said one man re-entered the club with a handgun and shot two people in the lower body.
The victims were taken to the hospital with what Wilson described as non-life threatening injuries.
This is the second incident involving gunfire at Club Crush within a week. Early Sunday morning, someone fired shots at two women who were leaving the club. Nobody was injured but several cars were damaged by bullets.
If you know anything about these incidents that can help deputies find the gunmen, call Crimestoppers at 1-888-Crime-SC.
Copyright 2013 WIS. All rights reserved.
1111 Bull St.
Columbia, SC 29201
(803) 799-1010
FCC Public File
EEO Report
Closed Captioning


text:
Here at SingleHop, a lot of people know we do things differently but they probably don't expect our company meetings to be different too! Last Thursday we held a company meeting after hours to discuss our recent growth and new data center while taking some much needed relaxation on our 3rd floor deck.
After a long discussion headed by President & CEO, Zac Boca, we decided it was time for a little bonding amongst coworkers and what better way than Whirlyball!?!For those of you who have not had the great pleasure of playing such a fine sport, whirlyball is a mix of bumper cars, lacrosse and basketball. Mix in the sales team's competitive drive with the tech's bone crushing strength and you've got yourself a SingleHop primetime event!
After several hours of ramming into one another and crashing into walls, the sales team was overwhelming victorious! (and I'm not just saying that because I am in sales!) Leading the way for the sales team was the undefeated, scoring machine known as Chris Larkin who was a terror up and down the court. When asked for a comment on the game, Chris replied, "What can I say?I was dominating so much.. I was already ramming someone else by the time I shot the ball into the target!"
In the end we decided to put down the whirlyball mitts and shoot each other in laser tag that is. Overall it was a fantastic night that lead to a lot of laughs and memorable moments for us SingleHopper's, however, the next day was a different story as it was filled with bruises, blisters, aches and pains!
Check out some of the photos for yourself!
That picture of the deck just doesn't do Chicago any justice… should have taken a wider/taller shot :/
Otherwise, I am proud to have contributed 0 to Sales winning whirlyball. I'll tell you one thing, I feel bad for those bumpercars!
being blind, i wanna play this game, think it would be hella fun:)
Being blind myself, i'd find it fun just to even hear what's going on with such a game. I wonder when the first time you'll get a "Quit having fun and fix my damn server", DreamHost gets that all the time (Shared host I kinda like).
Very different ,


text:
Open All | Close All
The school is part of the Parish of St Mary Help of Christians. There has been a long tradition of the school and parish working together. Here are some of the things we do to strengthen that bond:
We raise funds for CAFOD.
We go to mass weekly.
We have school Sunday Liturgies.
We have Easter and Christmas plays.


text:
Find all the TVS Jive colours here. Colors of TVS Jive listed here is for one or more variants of the Bike. Generally the popular Bike for any Bike model is the colour of the model shown in advertisment. Please check the availability of desired Jive colour with TVS dealers
TVS Jive is available in following Colors
* Colours of TVS Jive indicated here are subjected to changes and it may vary from actual Jive colors. TVS reserves the right to make any changes without notice concerning colours of Jive Bike or discontinue individual variant colors.


text:
By Claire Rutter On October 17, 2012
'Blow Me One Last Kiss' singer strips down following birth of daughter Willow…comments powered by Disqus
Get our top stories emailed to you each day.
Philanthropist's fundraising idea has gone massively viral
This year's VMAs are on Sunday
It was a nail biting episode last night
What's going on?
This is almost cruel
Dumbledore, Robin Williams and Ryan Gosling help keep things in perspective
Fans have been bulk downloading his track
X-Men director Bryan Singer shares his inking experience
Band have taken on the ALS ice bucket challenge
The comic book writer and artist isn't a fan of the adaptations of his characters
Kristian Nairn was snapped out in London
Also predicts that Brad 'still loves' Jennifer Aniston
He then put it in Karrueche's bag!
We don't know if she'll be taking them up on their 'offer' anytime soon...
There are some shockers in there!
And is Kim Kardashian to blame?
The bum fluff is no more
Was spotted at his concert this week
Trust us
First contestant will now be chucked out next week
Right, we're booking our plane ticket right now!
Looks like the sequel won't match the success of the 2005 film
Pair are still good friends
RaeLynn is a former act on The Voice
We actually can't deal with how adorable this video is
Billy and Robin were friends and worked together on the film 'Father's Day'
Actor is known to be one of the nicest guys in Hollywood
Doesn't seem too chuffed to have won all the money
Inspired by Reddit thread
The Blue boybander is the second guy to be confirmed for this year's show
Actor has passed away age 63 on August 11
Who wins?
It was halted because of Hans Solo's broken leg
The mother said that 'haters are gonna hate'
It's the big day nationwide
So they're back together we take it?
The statue will be a life-sized version of the songstress
The Mean Girls star has been seen jet setting around Europe a lot recently!
Janet was banned ten years ago....
The actress has yet to confirm her pregnancy, despite her big belly...
Let's hope so!
Andy Serkis's Jungle Book: Origins is taking shape
It seems the American actor's humour isn't going down too well with the others.
The actress is all about Sasha Fierce!
Are you ready for the bank holiday?
From now on it's all about the fun!
Can she overtake David Guetta by Sunday?
Zack Morris and co actually got up to some really strange stuff
A girl can dream...


text: House Series 6 - 22. Help Me Share: About this programme 22/22. The curmudgeonly doctor and his proteges join forces with a search-and-rescue team to provide much-needed medical attention at the scene of a disaster. Drama, starring Hugh Laurie. Cast and crew Cast Dr Gregory House Hugh Laurie Categories Drama Share:


text:
1232 S Reisner St has a Walk Score of 52 out of 100. This location is Somewhat Walkable so some errands can be accomplished on foot.
This location is in Indianapolis. Nearby parks include Rhodius Park, McCarty Triangle Park and Riley Park.
Nearby schools include William Penn School 49, Daniel Webster School 46 and Key Learning Community School.
The closest grocery stores are Safeway, Safeway Foods Inc. and Carniceria Gaunajuato.
Nearby restaurants include Subway, Wendy's and Barry's Pizza.
1232 S Reisner St is near Indiana University-Purdue University - Indianapolis, WellPoint Headquarters and Eli Lilly Headquarters.
There are minimal bike lanes and the terrain is flat as a pancake. 1232 S Reisner St is somewhat bikeable, there is minimal bike infrastructure.


text:
MOSREF is an exploitation architecture utilizing the power of the MOSVM virtual
machine and Mosquito Lisp to make penetration testing, exploit development,
and general systems security tasks more efficient.
While MOSREF has been developed primarily as a platform for exploitation and
penetration-testing, MOSREF and the underlying MOSVM virtual machine technology
can be used for a variety of security-related and non-security-related tasks.
Moreover, the platform is licensed under the GNU LGPL, and is redistributable
and modifiable under the terms of that license.
WWW: http://swik.net/mosref
NOTE: FreshPorts displays only information on required and default dependencies. Optional dependencies are not covered.
To install the port: cd /usr/ports/security/mosref/ && make install clean
cd /usr/ports/security/mosref/ && make install clean
A package is not available for ports marked as: Forbidden / Broken / Ignore / Restricted
No options to configure
Number of commits found: 14
Resetting maintainership on ports that have not been staged and without any
pending PR (related to stage)
With hat: portmgr
- Convert gmake, bzip2 to USES
Approved by: portmgr
Add NO_STAGE all over the place in preparation for the staging support (cat:
- Remove A/An in COMMENT
- Trim Header where applicable
-remove MD5
- Switch SourceForge ports to the new File Release System: categories starting
with P,R,S
- Mark BROKEN on amd64/7: segfault during build
Reported by: pointyhat
- Original website is now cyberquatted; point to a swik entry instead
- Update maintainer address
Reported by: bounce message
- Unmark BROKEN: no longer segfaults during build on amd64
Remove 4.X cruft.
BROKEN: Segfault during build on !i386
- Use OSVERSION instead of exist()
Noticed by: kris
Approved by: Piet Delport (maintainer, implicit)
Add mosref 2.0.b3, a secure remote execution framework using a compact
Scheme-influenced VM.
PR: ports/102238
Submitted by: Piet Delport
Servers and bandwidth provided byNew York Internet, SuperNews, and RootBSD
6 vulnerabilities affecting 9 ports have been reported in the past 14 days
* - modified, not new
All vulnerabilities


text:
Richard Corsi
Department Chair & Professor, Co-Director Center for Sustainable Development
E.C.H. Bantel Professorship for Professional Practice
Email: firstname.lastname@example.com
Phone: (512) 471-4921
Office: ECJ 4.200, EME 1.304B
Area(s) of Expertise:
Environmental and Water Resources Engineering
Educational Qualifications:
Ph.D., University of California at Davis, Civil Engineering, 1989
M.S., University of California at Davis, Civil Engineering, 1985
B.S., Humboldt State University, Environmental Resources Engineering, 1983
Technical Interests:
Indoor air quality. Sources, fate, and control of indoor air pollution. Homogeneous and heterogeneous indoor environmental chemistry. Human exposure to toxins in indoor environments.


text:
|The Payback book was
founded in 2001 on a simple two part philosophy:
Paybacks founder, Ted Shamp, spent 12 years with Entertainment Publications, (publishers of the Entertainment and Gold C coupon books) most recently as Regional Manager – Fundraising Division for Oregon/Idaho/Hawaii.
Upon leaving his position with Entertainment, Ted saw the need for a Vancouver area discount book…..one that allowed families to save money at HOME – not after driving a half hour to Portland.
It was also decided that Payback would give a generous 50% profit ($10 of the $20 purchase price) for every Payback book that a school sells….an unheard of concept in coupon book fundraising (other similar books start at a mere 20% profit).
It was this willingness to develop a true "50/50 partnership" with the local schools - while generating new customers for area merchants - that led to the success of the Payback book – and its place today as the favorite choice for Vancouver area families looking for new businesses to visit - and new ways to save money!
|Contact Us


text:
The effort between the New York Islanders and Nassau County to keep the Islanders where they belong started back in 2003. Given the financial position of the County, the Islanders developed a plan to fund the transformation of the Coliseum. This plan, which came to be known as the Lighthouse, included additional development necessary to fund the construction and other expense of a new home for the Islanders. While we have not yet had the time to review the "new vision" just released by Supervisor Murray and the Town of Hempstead for the redevelopment of the Coliseum site, it does not appear to achieve the goals of the County and the developer. Without this, the Town of Hempstead's "new vision" looks to be economically unviable for both the developer and owner of the site.The full joint statement from the Lighthouse Development Group and Nassau County Exec. Ed Mangano, preserved here for posterity and the what-not.
Jones Lang LaSalle, the project management company for the upcoming $500 million renovation of Madison Square Garden, has begun work on a feasibility study for an Islanders arena at Willets Point -- the property surrounding Citi Field, the second-year home of the Mets.>>A discussion-worthy bit from Chris Botta at FanHouse. Update: Katie Strang's source contradicts the story. The story says it's the Mets owners initiating the study here, but any bit of Plan B action is a nice sign. The MSG renovations JLL is managing look pretty sweet in this compilation at Blueshirt Banter. (Of course, money always buys you nice furniture, doesn't it?)
Actually, things may be more serious than that. Talk among NHL insiders is that the Islanders are now in deep financial trouble. Some are worried Wang may be the next NHL owner to toss the keys to the franchise to Bettman and say he is finished paying for losses in excess of $20-million (U.S) every year.David Shoalts, Globe & Mail, discussing six franchises that supposedly need advances on revenue/TV money. Just passing it on as FYI, as "talk among insiders" is, well, talk. Lot of couched language there. But once it's in the G&M, you know people will be citing it.
The plan would include a resort and casino with a new arena for the Islanders. "My administration has been in discussion with the Shinnecock Indian Nation with respect to Nassau Coliseum being listed as a site for an entertainment destination center and casino," Mangano said in a statement Tuesday.>>From a Newsday [sub.] update on Nassau Coliseum site plans. Mangano is going to "call Wang" to discuss. On the one hand, um, I guess casinos saved the Penguins! On the other hand, casinos as development-boosters are the resort of desperate communities. Is Nassau County really so desperate? Cough.
"And finally, know this: Brooklyn is very much in play. Queens is very much in play, although it's a close second to Brooklyn now. Suffolk is not a serious option. The Islanders will not leave the New York metropolitan area during this generation or the next one.">>from Chris Botta's latest assessment of the Lighthouse Project. Just thought that was worth capturing and sharing with followers of other teams. Here's hoping...
Rechler said there was "some sound, legitimate questioning" on the impact of the redevelopment plan, but he said board members also spent hours debating the project's traffic consultant, even though the methodology was backed by the Nassau County Department of Public Works. "You had amateurs arguing with experts," Rechler said.Impression of the Lighthouse Project zoning hearing from Scott Rechler, Charles Wang's real estate development partner in the project.
Know this: over the last two weeks, the lead agency (the Town of Hempstead) and the developers (Wang and Scott Rechler) have received green lights from the New York State Department of Transportation, the Nassau County Department of Public Works and the Department of Environmental Conservation. And yet, the Town of Hempstead wants to sit on the Lighthouse Project like George Costanza of "Seinfeld" taking his time with the Penske File.Town of Hempstead, up to its usual. Chris Botta with the astute analysis.
"... For seven years, Charles Wang has committed himself, both emotionally and financially to keeping the Islanders here ... I am a native Islander, and I support the Lighthouse project. And I don't believe there is any place that the Islanders should be playing but here on Long Island."Gary Bettman at today's Lighthouse events, eliciting an ovation rarely heard outside of NHL Board of Governors meetings.
"Wang came away very optimistic with the events of today, satisfied that he was able to speak to Murray for the first time since January. He looks forward to meeting Friday with Murray, Suozzi, and Rechler at Suozzi's office. But he made one thing clear: the October deadline has not changed.">>From Jim Baumbach's extensive Newsday live blog of the Lighthouse meeting today. More reaction/coverage links to come tomorrow.
Kate Murray did not show up for a planned meeting with Wang and Democratic county leaders recently, but she had time to hire her 83-year-old father for a $40-an-hour part-time job in the town attorney's office. With priorities like that, it is hard to imagine keeping the Islanders.>>George Vecsey in a reflective 'Sports of the Times' column that is both interesting and annoying. We've seen this version from many ex-Islanders fans. It goes like this: "I have nostalgia for a bygone era, and because that era is gone and I am older, just let the franchise go rather than replenish it." This happens a lot when something isn't as hot as when it came out. People who have lost interest would rather put their memories in a cozy, closed time capsule rather than watch others keep the thing alive in an imperfect state that doesn't live up to their memory of the golden years. I'm sorry there can never be another dynasty, but you can exit the bandwagon at any time without advocating its demise.
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text:
Our only hope is that Katie Blackburn's daughter marries a football genius.
Our only hope is that Katie Blackburn's daughter marries a football genius.
I'm interested in jobs and you won't create jobs by forcing employers to pay their employees $9/hr- Sea Ray
I'd say min wage should be about $9/hr - Sea Ray
raiders are driving however, and broncos game is almost over
Haloti Ngata called for a "clearly unnecessary hit".
Nothing deep and Ravens have tightened up underneath.
If you have a losing record at Reds games, please stop going.
Not Dalton's best day.
Looks like OAK TD but Chiefs are close to closing out BRonco
Denver has to punt with 2:37 left
Terrible series of plays once again for the Bengals inside the 10.
Nugent hits from 23, 24-16
Dalton looked like a rookie big time there....what is he thinking about?
Wow they punted, thought Fox would go for it.
If you have a losing record at Reds games, please stop going.
Denver out of timeouts, 2:20 left. 3rd down after 2 min warning by my math, 1:15ish left after punt for denver.
How can they be this bad at clock management?
Grape works as a soda. Sort of as a gum. I wonder why it doesn't work as a pie. Grape pie? There's no grape pie. - Larry David
Hate getting the FG there, but the O was stagnant and the clock was running.
If you have a losing record at Reds games, please stop going.
Chiefs short on third down, punt up-coming...
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text:
PLYMOUTH — Good Friday, April 6, the youth group at Trinity United Methodist Church in Plymouth will participate in the 30 Hour Famine, fasting from midnight Friday to 6 a.m. Saturday morning. They do so for two reasons: the first is in solidarity with those young people at home and all over the world who do not have enough to eat and, second, to gain money and support for the cause of ending poverty everywhere.
Culver Dive Team members Brandon Cooper, Bob Cooper Kr and Jerry Siler, along with county officers and a DNR officer, were on the scene of this truck in Lake Maxinkuckee Wednesday afternoon. No official information has been released, but bystanders said no one hurt.
PLYMOUTH — The remnants of two meth labs were discovered in the woods behind Washington Elementary School during spring break, according to a report from the Plymouth Community School Corporation Wednesday.
The school was notified of the situation by a parent. They have roped off the area and are taking steps to ensure students do not enter the woods during recess.
An environmental management firm will be assessing the area and advising the school on an appropriate response. Parents of Washington Elementary students have been informed of the situation.
PLYMOUTH — The first meet of the year is always a little dicey. Especially with a young team. Even more so coming off of spring break.
Nevertheless, Plymouth's boys track team got off to a solid start Tuesday, splitting a three-way meet with a loss to a deep Mishawaka squad — which put up 69 points to top the field — and a narrow 32-30 victory over LaPorte at home at The Rockpile.
The past is past.
Following Culver Com-munity's first sectional championship in 25 years last season, that's the message head coach Mike Elliott and his staff are sending to the Cavaliers this year.
With just four starters back in pitcher and utility player Collin Stevens, second baseman/ pitcher Sam Hissong, short stop/ pitcher Kyle Vlach and center fielder Nick Pritz, Elliott is hoping his largely inexperienced team can find an identity of its own in 2012 rather than resting on the laurels of last season's historic finish.
Pilgrims win season-opener
Hayden Skirvin knocked in three runs, and Plymouth used a four-run sixth to beat South Central 7-3 in the Pilgrims' season-opener on the road in Union Mills Tuesday.
Jordan Scheetz got the win on the mound, giving up five hits.
Plymouth returns to action at home tonight against St. Joe.
• PLYMOUTH 7, SOUTH CENTRAL 3
At Union Mills
Plymouth: 011 004 1 — 7 6 3
South Central: 020 001 0 — 3 5 3
Jordan Scheetz (W, 1-0) and Jacob Seagraves; Ben Rosebaum (L), Garrett Walter (7) and Josh Mohlke.
JV score: Plymouth 9, Rochester 6.
PLYMOUTH — Plymouth High School math teachers Michael Delp and Earl Boyer recently solved an equation they can take great pride in.
The two collectively lost more than 150 pounds in just 10 weeks to win the "Best Loser" competition — and the grand prize of $1,000 — at Fitness Forum.
"It was pretty exciting," said Boyer. "We didn't pressure each other, but I think we both put pressure on ourselves to pull our own weight on the team. Each of us wanted to do a good job for the other. I wouldn't have been able to do this well on my own."


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Treatment Bladder Infection
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text:
The Rotary Club of Joplin held a groundbreaking today for the Will Norton Miracle Field at the Joplin Athletic Complex.
The field will be a flat and smooth baseball field accessible to all children.
The field is named in honor of Will Norton, a recent high school graduate who died in last year's tornado.
Norton helped out a lot for Rotary camps and in volunteer projects.
"We are honored, obviously and it's such a great thing," says Will's father, Mark Norton. "Our son was always about helping others and it just fit his legacy so well and we know what he would - this is exactly what he would want to be a part of. We are truly honored."
The field will also feature the only handicap accessible playground in Joplin.