text:
Great Britain has recently been hit by a wave of metal thieves who appear to spare nothing in their path. Manhole covers, lead from church roofs, electric cables, even memorial statues and plaques with the names of war dead are vanishing in the face of rising demand from Asia and a recycling industry that pays in cash and asks no questions.
The disappearances, which police say cost communities hundreds of millions of pounds a year, even forced a hospital in Wales to postpone critically-needed operations this month when one of its generators was stolen.
The thefts have aroused widespread outrage and are being blamed by some on moral decay, but others point to Britain's current austerity regime as the cause.
Reuters notes that "since January 2009, the price of the type of copper popular with thieves has more than doubled on the London Metal Exchange. Meanwhile, many more Britons' finances are being squeezed by the harshest public spending cuts for a generation, part of government plans to tackle a big budget deficit."
Police are increasing their efforts to deal with the problem, but so far there have been almost no arrests.
This video was uploaded to YouTube by AlJazeeraEnglish on December 30, 2011.
By Katie Halper
By TBogg
By Roy Greenslade, The Guardian
By The Conversation
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text: tag:cincinnatilibrary.org,2007:NewArrivals:biographical_fiction Biographical Fiction 2014-08-06T11:21:23-04:00 The Public Library of Cincinnati and Hamilton County http://www.cincinnatilibrary.org/ These titles were recently added to the collection of the Public Library of Cincinnati and Hamilton County. http://www.cincinnatilibrary.org/spotlight/feeds/newarrivals.png 2978740 The remarkable courtship of General Tom Thumb : a novel 2014-08-05T00:00:00-04:00 Rinaldi, Nicholas, 1934- New York : Scribner, 2014. 372 pages ; 24 cm "Weaves together a ... behind-the-scenes look at life during the Civil War and a ... tale of one misfit's odyssey to find his place in the world. Discovered at age four by P.T. Barnum, Tom Thumb soon finds himself traveling internationally, sitting on the laps of the queens of Europe, and entertaining the masses ... After marrying Lavinia Warren, Tom and wife are hosted at the White House by President Lincoln. With the country at war, Tom and Lavinia set out on their honeymoon tour and witness firsthand the fracture between the states, the heroism of young soldiers, and the unbreakable spirit of the American people" -- Provided by publisher. 2980857 Jane Austen's first love 2014-07-25T00:00:00-04:00 James, Syrie. New York : Berkley Books, 2014. 391 pages ; 21 cm Includes discussion questions. "A novel"--Cover. "Fifteen-year-old Jane Austen dreams of three things: doing something useful, writing something worthy, and falling madly in love. When she visits her brother in Kent to celebrate his engagement, she meets wealthy, devilishly handsome Edward Taylor-a fascinating young man who is truly worthy of her affections. Jane knows a match between her and Edward is unlikely, but every moment she spends with him makes her heart race-and he seems to return her interest. Much to her displeasure, however, there is another seeking his attention Unsure of her budding relationship, Jane seeks distraction by attempting to correct the pairings of three other prospective couples. But when her matchmaking aspirations do not all turn out as anticipated, Jane discovers the danger of relying on first impressions. The human heart cannot be easily deciphered, nor can it be directed or managed. And if others must be left to their own devices in matters of love and matrimony, can Jane even hope to satisfy her own heart? "-- Provided by publisher. 2980918 The crossing 2014-07-25T00:00:00-04:00 Kienzle, Barry, author. ©2014. 176 pages ; 22 cm. 2979290 A question of bounty : the shadow of doubt 2014-07-18T00:00:00-04:00 Colt, Paul. Waterville, Maine : Five Star, [2014]. 359 pages ; 23 cm 2979319 Flight of the sparrow : a novel of early America 2014-07-18T00:00:00-04:00 Brown, Amy Belding. ©2014 331 pages ; 21 cm Includes a readers guide. A historical novel based on the life of Mary Rowlandson. Even before she was captured by Indians on a winter day of violence and terror, Mary Rowlandson sometimes found herself in conflict with her rigid Puritan community. Now, her home destroyed, her children lost to her, she has been sold into the service of a powerful woman tribal leader and made a pawn in the ongoing bloody struggle between English settlers and native people. Battling cold, hunger, and exhaustion, Mary witnesses harrowing brutality but also unexpected kindness. To her confused surprise, she is drawn to her captors' open and straightforward way of life. 2974991 The confessions of Frances Godwin : a novel 2014-07-08T00:00:00-04:00 Hellenga, Robert, 1941- New York : Bloomsbury USA, 2014. 305 pages ; 22 cm "The Confessions of Frances Godwin is the fictional memoir of a retired high school Latin teacher looking back on a life of trying to do her best amidst transgressions--starting with her affair with Paul, whom she later marries. Now that Paul is dead and she's retired, Frances Godwin thinks her story is over--but of course the rest of her life is full of surprises, including the truly shocking turn of events that occurs when she takes matters into her own hands after her daughter Stella's husband grows increasingly abusive. And though she is not a particularly pious person, in the aftermath of her actions, God begins speaking to her. Theirs is a deliciously antagonistic relationship that will compel both believers and nonbelievers alike. From a small town in the Midwest to the Piazza Santa Maria in Trastevere in Rome, The Confessions of Frances Godwin touches on the great questions of human existence: Is there something "out there" that takes an interest in us? Or is the universe ultimately indifferent?"-- Provided by publisher. 2975991 The Summer Queen : a novel of Eleanor of Aquitaine 2014-07-08T00:00:00-04:00 Chadwick, Elizabeth, 1957- Naperville, IL : Sourcebooks Landmark, c 2014. 504 p. : maps, geneal. tables ; 21 cm. Young, golden-haired and blue-eyed Eleanor has everything to look forward to as the heiress to wealthy Aquitaine. But when her beloved father dies suddenly in the summer of 1137, her childhood is over. Forced to marry the young prince Louis of France, she barely adjusts before another death catapults them to being crowned King and Queen of France. Leaving everything behind, Eleanor must face the complex and vivacious French court. She is only 13. Barely out of childhood, and forced to deal with great scandals, fraught relationships and forbidden love at every turn, Eleanor finally sees what her future could hold if she could just seize the moment. 2975993 Sisters of treason 2014-07-08T00:00:00-04:00 Fremantle, Elizabeth. New York : Simon & Schuster, 2014. 436 pages : genealogical table ; 25 cm "Originally published in 2014 in Great Britain by Penguin Group"--Title page verso. "A novel"--Jacket. "Beginning early in Mary Tudor's turbulent reign, [this book] explores the lives of a pair of sisters as dangerously close to the throne as their sister Lady Jane Grey, who died on the executioner's block at the age of 16, after being queen for nine days"-- Provided by publisher. 2970236 Song of the shank : a novel 2014-06-13T00:00:00-04:00 Allen, Jeffery Renard, 1962-, author. ©2014 570 pages : illustrations, map ; 23 cm "In 1866 as Tom and his guardian, Eliza Bethune, struggle to adjust to their fashionable apartment in the city in the aftermath of riots that had driven them away a few years before. But soon a stranger arrives from the mysterious island of Edgemere, inhabited solely by African settlers and black refugees from the war and riots, who intends to reunite Tom with his now-liberated mother."--Page [4] of cover. 2970218 The last magazine : a novel 2014-06-10T00:00:00-04:00 Hastings, Michael, 1980-2013. New York : Blue Rider Press, a member of Penguin Group (USA), [2014] 336 pages ; 24 cm "A posthumous debut novel, wry, wise, and outrageous, from award-winning journalist Michael Hastings, based on his experiences working for a National news magazine in the mid-2000s"-- Provided by publisher. 2966685 Dreaming for Freud : a novel 2014-05-29T00:00:00-04:00 Kohler, Sheila. New York : Penguin Books, 2014. 232 pages ; 20 cm 2969076 What is visible : a novel 2014-05-29T00:00:00-04:00 Elkins, Kimberly. New York : Twelve, [2014]. 307 pages : illustration ; 24 cm 2966496 The untold 2014-05-23T00:00:00-04:00 Collins, Courtney. New York : Amy Einhorn Books, Published by G.P. Putnam's Sons, a member of Penguin Group (USA), 2014. 274 pages ; 22 cm Previously published by: London : Allen & Unwin 2012, as Burial. On the run from two bounty hunters in the Australian outback of 1921, Jessie reflects on her past as a circus rider, horse thief, cattle rustler, and convict while determinedly struggling to reunite with her child. 2966504 Red or dead : a novel 2014-05-23T00:00:00-04:00 Peace, David, author. Brooklyn, NY : Melville House, 2014. 720 pages ; 24 cm 2970348 Mrs. Hemingway : a novel 2014-05-23T00:00:00-04:00 Wood, Naomi. New York, New York : Penguin Books, 2014. 322, 10 pages ; 20 cm Subtitle from cover. "First published in Great Britain by Picador, an imprint of Pan Macmillan, a division of Macmillan Publishers Limited 2014"-- Title page verso. "The Paris Wife was only the beginning of the story. Paula McLain's New York Times-bestselling novel piqued readers' interest about Ernest Hemingway's romantic life. But Hadley was only one of four women married, in turn, to the legendary writer. Just as T.C. Boyle's bestseller The Women completed the picture begun by Nancy Horan's Loving Frank, Naomi Wood's Mrs. Hemingway tells the story of how it was to love, and be loved by, the most famous and dashing writer of his generation. Hadley, Pauline, Martha and Mary: each Mrs. Hemingway thought their love would last forever; each one was wrong. Told in four parts and based on real love letters and telegrams, Mrs. Hemingway reveals the explosive love triangles that wrecked each of Hemingway's marriages. Spanning 1920s bohemian Paris through 1960s Cold War America, populated with members of the fabled "Lost Generation," Mrs. Heminway is a riveting tale of passion, love, and heartbreak"-- Provided by publisher. 2966696 My struggle. Book three : boyhood 2014-05-19T00:00:00-04:00 Knausgård, Karl Ove, 1968- Brooklyn, NY : Archipelago Books, 2014. 427 p. ; 20 cm. "First published as Min kamp Tredje bok by Forlaget Oktober in 2009."--T.p. verso. "A family of four--mother, father and two boys--move to the South Coast of Norway to a new house on a newly developed site. It is the early 1970s and the family's trajectory, upwardly mobile: the future seems limitless. In painstaking, sometimes self-lacerating detail, Knausgaard paints a world familiar to anyone who can recall the intensity and novelty of childhood experience, one in which children and adults lead parallel lives that never meet. Perhaps the most Proustian in the series, Book Three gives us Knausgaard's vivid, technicolor recollections of childhood, his emerging self-understanding, and the multilayered nature of time's passing, memory, and existence."--Amazon.com 2944390 The Last Kind Words Saloon : a novel 2014-05-13T00:00:00-04:00 McMurtry, Larry. New York : Liveright Publishing Corporation, A Division of W. W. Norton & Company, [2014] 196 pages : illustrations ; 25 cm Traces the rich and varied friendship of Wyatt Earp and Doc Holiday from the town of Long Grass to Buffalo Bill's Wild West Show in Denver, then to Mobetie, Texas, and finally to Tombstone, Arizona, culminating with the famed gunfight at the O.K. Corral. 2964319 The year she left us : a novel 2014-05-13T00:00:00-04:00 Ma, Kathryn. New York : Harper, 2014. pages cm 2957524 Nine rabbits 2014-04-16T00:00:00-04:00 Zaharieva, Virginia. New York : Black Balloon Publishing, c2014. 186 p. ; 21 cm. 2956794 The Shadow Queen 2014-04-09T00:00:00-04:00 Gulland, Sandra. ©2014. 321 pages : genealogical table ; 25 cm "A novel"--Jacket. Pulled by chance from her traveling actor family into service under the influential mistress of Louis XIV, Claudette uses her considerable talents to spy on personal and political rivals, only to have her loyalty questioned in the wake of a mercurial Athénaïs's fascination with dark magic. 2956734 The secret life of William Shakespeare 2014-03-31T00:00:00-04:00 Morgan, Jude, 1962- New York : St. Martin's Press, 2014. 438 pages ; 22 cm Originally published: Great Britain : Headline Review, 2012. A sumptuously detailed imagining of the private world of the master bard chronicles the transformation of an unwilling craftsman and resentful son into a husband, father and genius playwright in Renaissance London. 2956728 The Red Lily Crown : a novel of Medici Florence 2014-03-21T00:00:00-04:00 Loupas, Elizabeth. New York : NAL Trade, 2014. 418 pages : maps ; 21 cm " Elizabeth Loupas returns with her most ambitious historical novel yet, a story of intrigue, passion, and murder in the Medici Court... April, 1574, Florence, Italy. Grand Duke Cosimo de' Medici lies dying. The city is paralyzed with dread, for the next man to wear the red lily crown will be Prince Francesco: despotic, dangerous, and obsessed with alchemy. Chiara Nerini, the troubled daughter of an anti-Medici bookseller, sets out to save her starving family by selling her dead father's rare alchemical equipment to the prince. Instead she is trapped in his household-imprisoned and forcibly initiated as a virgin acolyte in Francesco's quest for power and immortality. Undaunted, she seizes her chance to pursue undreamed-of power of her own. Witness to sensuous intrigues and brutal murder plots, Chiara seeks a safe path through the labyrinth of Medici tyranny and deception. Beside her walks the prince's mysterious English alchemist Ruanno, her friend and teacher, driven by his own dark goals. Can Chiara trust him to keep her secrets;even to love her;or will he prove to be her most treacherous enemy of all?"-- Provided by publisher. 2945354 Roosevelt's beast : a novel 2014-03-20T00:00:00-04:00 Bayard, Louis. New York : Henry Holt and Company, [2014]. 299 pages : map, genealogical table ; 25 cm "A reimagining of Teddy and Kermit Roosevelt's ill-fated 1914 Amazon expedition--a psychological twist on the smart historical thriller that first put Louis Bayard on the map. 1914. Brazil's Rio da Dúvida, the River of Doubt. Plagued by hunger and suffering the lingering effects of malaria, Theodore Roosevelt, his son Kermit, and the other members of the now-ravaged Roosevelt-Rondon scientific expedition are traveling deeper and deeper into the jungle. When Kermit and Teddy are kidnapped by a never-before-seen Amazonian tribe, the great hunters are asked one thing in exchange for their freedom: find and kill a beast that leaves no tracks and that no member of the tribe has ever seen. But what are the origins of this beast, and how do they escape its brutal wrath? Roosevelt's Beast is a story of the impossible things that become possible when civilization is miles away, when the mind plays tricks on itself, and when old family secrets refuse to stay buried. With his characteristically rich storytelling and a touch of old-fashioned horror, the bestselling and critically acclaimed Louis Bayard turns the story of the well-known Roosevelt-Rondon expedition on its head and dares to ask: Are the beasts among us more frightening than the beasts within?" -- from publisher's web site. 2947080 Seducing Ingrid Bergman 2014-03-20T00:00:00-04:00 Greenhalgh, Chris, 1963- New York : St. Martin's Press, [2014]. 259 pages ; 22 cm Originally published: London : Penguin Group, 2012. "June 1945. When Ingrid Bergman walks into the lobby of the Ritz hotel in Paris, war photographer Robert Capa is enchanted. From the moment he slips a mischievous invitation to dinner under her door, the two find themselves helplessly attracted. Played out against the cafés and nightclubs of post-war Paris and the parties and studios of Hollywood, they pursue an intense and increasingly reckless affair. But the light-hearted Capa, who likes nothing more than to spend his mornings reading in the tub and his afternoons at the racetrack, is not all that he seems. And Ingrid offers the promise of salvation to a man haunted by the horrors of war, his father's suicide, and the death of a former lover for which he blames himself. Addicted to risk, Capa must wrestle his devils, including gambling and drink, and resist an impulse to go off and photograph yet another war. Meanwhile, Ingrid, trapped in a passionless marriage and with a seven-year-old daughter to bring up, must court scandal and risk compromising her Hollywood career and saintly reputation if their love is to survive. With their happiness and identities at stake, both Capa and Ingrid are presented with terrible choices" -- from publisher's web site. 2947081 Queen Elizabeth's daughter : a novel of Elizabeth I 2014-03-20T00:00:00-04:00 Barnhill, Anne Clinard. New York : St. Martin's Griffin, [2014]. 371 pages ; 22 cm. "Mistress Mary Shelton is Queen Elizabeth's favorite ward, enjoying every privilege the position affords. The queen loves Mary like a daughter, and, like any good mother, she wants her to make a powerful match. The most likely prospect: Edward de Vere, Earl of Oxford. But while Oxford seems to be everything the queen admires: clever, polished and wealthy, Mary knows him to be lecherous, cruel, and full of treachery. No matter how hard the queen tries to push her into his arms, Mary refuses. Instead, Mary falls in love with a man who is completely unsuitable. Sir John Skydemore is a minor knight with little money, a widower with five children. Worst of all, he's a Catholic at a time when Catholic plots against Elizabeth are rampant. The queen forbids Mary to wed the man she loves. When the young woman, who is the queen's own flesh and blood, defies her, the couple finds their very lives in danger as Elizabeth's wrath knows no bounds"-- Provided by publisher.

subset: commoncrawl


text: Lesser-known serial killer Paul Michael Stephani, aka the Weepy-Voiced Killer, was known for his signature calls to 911 after each attack. He would beg the operator in a high-pitched weepy voice for someone to send the victim help, or for someone to stop him from killing again. Then he would hang up, never identifying himself.


text:
Yeah, I know that sounds so "Zuckerbergian", and I really mean no malice to Boise State and the beautiful state of Idaho, but are you kidding me? I saw bits and pieces of Boise's latest massacre of Louisiana Tech (I believe) on ESPN's Tuesday Night Special, and it really made me realize how far from good our football program really is.
The kids that play for Chris Peterson/sen are not five-star athletes, and Boise is seldom their first choice, but they play with heart, discipline, spirit, and (dare I say) Wooden-like, relentless execution. I saw a tight-end run a skinny post and the QB read the defense and had the time to make a 12 yard pass, that resulted in a 35-yard TD. Instead of waiving his arms around like a circus baffoon, the guy dropped the ball, gave some high fives, and everyone set up for an extra point attempt. This was no dream . . . it really happened.
I'm jealous of Boise State.


text:
Photographs of The Little Theatre of Tuscarawas County's production of "I Hate Hamlet".
Theatre location: New Philadelphia, Ohio
Performance dates: April 20-May 5, 2007
Director: Corey Zickel
Assistant Director: L. Thomas Albury
Chad Roberts, Richard Benson, Lori Schlabach, Missy Zickel, Don Lane, Jackie Luthy.
Pam Douglas, Karen Moffit, Jimmy Abbuhl, Debi DeVore, Missy Zickel, Gayle Krieger.


text:
An 800W head with advanced features, Acoustic technology and power to spare.
The new B800H 800W Bass Amp Head from Acoustic lets you take "the pro's tone" to a whole new level with 800 watts of output at your fingertips. Pro features include an overdrive channel with separate volume control, notch filter with sweepable frequency, 6-band EQ with shape control, Acousti-comp compression, and footswitchable output defeat. The rear panel includes both 1/4" and locking speaker jacks, full-function direct output and a special link feature that allows you to slave another B800H head. Get the "pro's tone" with power to spare - the B800H from Acoustic.


text:
Dear President Obama: Should we sell our house?
by Craig J. Cantoni
Your Excellency:
This is your humble servant. I'm writing from my home in the Sonoran desert of Arizona, where it's 113 degrees outside and 82 degrees inside. I'm sitting here half-naked with the ceiling fan whirring so fast that papers are flying off my desk.
It gives me solace, though, to know that you and Michelle probably have the thermostat set at a comfortable 72 degrees in that big white house in Washington. I hope it's just as comfortable in the big home you own in Chicago, whether it's empty or being rented by someone.
If King Louis XIV of France deserved to live in Versailles while preaching to his lords about the living conditions of the serfs, then you deserve to live in luxury while preaching to plebeians like me about global warming. After all, Louie believed in the Divine Right of Kings, just as you believe in the Divine Right of Presidents. And like you, Louie was able to centralize power and raise taxes because his subjects were fed up with the wars of his predecessors. Were they ever surprised, however, when he would later engulf France in war. Still, Louie was able to stay on the throne and build monuments to his narcissism, thanks to having the undying loyalty of the propagandists at CBS, NBC, ABC, CNBC, CNN, PBS, NPR, the New York Times, K-12 schools, and universities.
Oh, sorry, I got him confused with you.
I'm turning to you for advice, your majesty, because you learned everything about everything at Harvard Law, including everything there is to know about real estate and climate change. Accordingly, I'd be honored if you'd give me your opinion on whether my wife and I should sell our house and move to a townhouse half the size, which, because of the peculiarities of the local market, is priced the same as our house. We'll be empty-nesters next month and, because of your unwavering belief that humans are causing the Earth to warm, we'll be facing rising costs for heating and air-conditioning.
As an aside, people I know who are the most learned in science and the scientific method have the most doubts about the unproven hypothesis about global warming and CO2. Obviously, their opinions are worthless, because they didn't attend Harvard Law, which is renowned for its expertise in meteorology and climatology.
Currently, the electricity for our all-electric home comes from one of the largest nuclear power plants in the country. Last year, our total utility bill was $3,368.70 for a 3,860 sq. ft. home. To save electricity, I sometimes shower outside during the summer under a homemade shower that is hooked up to 50 feet of garden hose, which is heated by the sun. I think I'm violating a rule of the homeowner's association, so please don't tell them.
It's a mystery to me why customers of Arizona Public Service should face rising energy costs from your climate legislation when our electricity isn't generated by burning fossil fuels. Could you explain that?
My guess is that it has something to do with the fact that many of your adoring constituents are Northeastern bluebloods and Brahmins who live in big, old, drafty, and energy-inefficient frame houses, many of which are heated with oil. Surely, they're going to expect you to bail them out with hidden energy subsidies at the expense of red-state people like me.
Normally, I'd make such an important decision as selling a house without coming to you, but real estate values have historically been whipsawed by the arbitrary and contradictory decisions of politicians. (Arbitrary political decisions have caused similar distortions in the markets for medical care, education, and energy.)
For example, when we bought our current home in 1992, we had to buy a larger and more expensive house than we needed in order to avoid the IRS's capital gains rule in effect at the time. Now your central planners, who drive around Washington in government-issued Chevy Suburbans, want to get people out of suburban homes and into high-density housing along mass transit lines.
Another example: Because you and your Democrat party have always been opposed to education vouchers, home buyers with the means have selected neighborhoods based on the quality of the local public school. This has led to an exodus from central cities and has caused neighborhoods to be segregated by race and socioeconomic status. With vouchers, parents could live anywhere and send their kids to good schools, wherever they might be located.
Still another example: Because of the government's easy money policies, its backing of the Congressional playpens of Fannie Mae and Freddie Mac, its longstanding loony belief that housing is a good investment, its tax deduction for mortgage interest, its tax dodges for investor-owned real estate -- because of all these reasons, the housing market expanded into a bubble and then burst, with the fragments landing in the toilet. Thankfully, we have a federally-approved toilet that doesn't use much water per flush, although we have to flush several times per visit and keep a plunger handy.
I hate to break this to you, your highness, but even a plunger won't unclog the blockage in the housing market caused by your economic policies, which have made things worse and protracted the inevitable correction. Now, uncertainty over what you might do next has caused other markets to become clogged.
Home prices have plummeted about 40 percent on average in Phoenix. Three of the seven homes for sale in our neighborhood were bought by investors during the bubble, in the hope of flipping them for a profit. To illustrate, an investor bought one of the houses two years ago for $850,000, made cosmetic changes to it to fool buyers who are easily fooled by cosmetics, and put it back on the market for $1.2 million. He since has reduced the asking price several times to the current price of $799,000, which is probably $150,000 too high. Idiots like him, responding to government incentives, tax deductions, and easy money, have hurt everyone else.
In his defense, no one in the government or media warned the public that a bubble was forming, although the data were readily available and indisputable. For example, Yale professor Robert Shiller published data showing that home prices had skyrocketed 99 percent above the historic mean. Unfortunately, he is an economist and not a Harvard lawyer, so his insights and predictions were ignored.
Well, those are the facts. Please tell me what my wife and I should do, based on whatever diktats you and your apparatchiks are hatching. Should we:
a. Stay put and start going naked in the house in the summer? (For some reason, my wife is less keen about this idea than I am.)
b. Sell our house for peanuts, get rid of most of our possessions, and move into a tiny townhouse? (Not to be nosy, but will you and Michelle be doing the same?)
c. Wait until Americans come to their senses and vote you out of office?
Thank you for your answer.
With all due deference,
Your hot and obedient servant,
Craig J. Cantoni
An author and columnist, the sweltering Mr. Cantoni can be reached poolside at firstname.lastname@example.com.
Sunday, July 12, 2009
Bare facts and naked truths of a whoredog economy
Dear President Obama: Should we sell our house?
4 comments:
- Anonymous said...
As usual - your comments are superb. I've copied them and I'm going to send them to my co. tax asser ,collector here in texas who states that my home has increased in value $ 10,000.00 this year and they are raising my property taxes approately ! Never mind that texas is in the top 7% in home reposessions and the fact that property values have droped in the last 2 years! Same old story, The rich are still stealing from the poor! I know noone will believe this but, Our elected state officials don't care - "The hell you say".
- Gary D. said...
Very good, Craig. I enjoy despising him about as much as you, I'm sure.
Thanks for a great read ...
Gary D.
Gilbert, AZ
- Alinka said...
Dear Michelle,
I just read a fantastic piece of truthful literature by my friend Craig Cantoni. I think you should read it. You might learn a thing or two, especially about royalty. First, never tell anyone, especially not in front of a microphone that you have "never been proud of this mean country," because people have good memories. That statement will jump up to bite you in your fat black ass one day.
Secondly, don't paw the queen. She is not into a "give me a high five; right on; hey bro;" type of introduction. She prefers a curtsy. Otherwise you prolong the myth of the ugly American overseas; and some of us have a lot of class. Something you are seriously lacking!
It is only a matter of time before the southern population in this GREAT country starts to call your husband an "Uncle Tom." I think the African-Americans in Florida who picketed him on his recent trip down south, as uneducated as they were, were smart enough to realize they had been duped. Didn't you read the signs they held and the insults they hurled at him?
Michelle, I write to you in the spirit of friendship, to inform you that you still have three and a half years left for "change."
You can do it. All you have to do is ask Oprah for advice. Then tell the Blacks who voted for the president, notice I say president, not you, why your husband with the laughing face and nice white teeth, has not kept his promise to them. Take a page out of Hillary's book about baking cookies. You were not voted into office, so you have no power. The maids you fired will find a Gloria Allred to write their gossip and make more money selling their snitching on the Oprah Show than you will with your book. And don't try to impress me with your visit to the Kremlin. Been there, done that. Or to the Vatican, ditto. France -- and the other socialist whom Obama is trying to emulate. How's your French, babe? Mine's fair.
As one woman to another, I will let you in on a little secret. Start making an outline to write your memoirs now, because you are going to need the money when Barack gets kicked out of office in the near future. You see, I have a lot of unhappy friends who love to communicate via email, and we are getting organized. Your husband does have a fine future in Hollywood because the liberals who supported him will be offering him roles -- usually type cast; so don't get offended when they only offer him parts for drug peddlers or crooked politicos, because that's life! They tend to be a little myopic.
And Michelle, pluuuuuuuease, when the camera is on you stop making monkey faces. As a first lady this is a source of embarrassment to us. In fact, your husband's entire administration is a sore spot for us conservatives.
You know -- I wasn't born in this beautiful country -- I chose to become an American because I believed in the ideals, but I think I will run for president. Why not? Your husband lied and said he was born in Hawaii, making a mockery of the constitution.
But fortunately, my ambition is less than my love for the USA; and nobody will dare insult it in my presence. Not even you, or I'll shove the flag up your -- er, at the cost of being redundant, where the Arizona sun don't shine!
Respectfully submitted,
Princess Alice
Craig, that was hilarious, especially the part of you sitting naked. Did you publish it somewhere? Send it to Cave Creek. Keep up the pressure on Obama, maybe you can do it on the net. He hates bad publicity, so let's give him a shovelful.
- Mark Yannone said...
@ Alinka
Yes, Alinka, Craig's "Dear President Obama: Should we sell our house?" was published here and here.
Mark Yannone


text:
VIRGINIA CITY, Nev. (AP) -- Authorities in northern Nevada are trying to determine whether human remains were pumped out of a septic tank north of Virginia City. Storey County Sheriff Gerald Antinoro says his office hasn't confirmed whether the discovery is human remains, but has reason to believe it may be. He tells the Reno Gazette-Journal it's unlikely people would throw animals down a septic tank, and says other items were found with the suspicious material. Antinoro says the current residents at the house have lived there for decades, but aren't suspected of any wrongdoing. He didn't release their names and address. He told the newspaper the remains were being sent to the Washoe County medical examiner's office Tuesday for review.
KTVN-TVPhone: (775) 858-2222Fax: (775) 861-4298
Mailing Address:4925 Energy WayReno, NV 89502


text:
Research Topics
Genomes and Genes
Summary: Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications196 found, 100 shown here
- 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancerLaura E Lantry
Ernst Felder Laboratories, Bracco Research USA Inc, Princeton, New Jersey 08540 6608, USA
J Nucl Med 47:1144-52. 2006..We describe a new radiolabeled bombesin (BBN) analog for imaging and systemic radiotherapy that has improved pharmacokinetics (PK) and better retention of radioactivity in the tumor...
- [177Lu-DOTA(0),Tyr3] octreotate for somatostatin receptor-targeted radionuclide therapyM De Jong
Department of Nuclear Medicine, University Hospital and Erasmus University Rotterdam, 3015 GD Rotterdam, The Netherlands
Int J Cancer 92:628-33. 2001..This candidate molecule shows great promise for radionuclide therapy in patients with sst(2)-expressing tumors...
- Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumorsHanwen Zhang
Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel
Cancer Res 64:6707-15. 2004..The aim of this study was to develop radiolabeled (Indium-111, Lutetium-177, and Yttrium-90) bombesin analogues with affinity to the three bombesin receptor subtypes for targeted ..
- Dosimetric analysis of 177Lu-cG250 radioimmunotherapy in renal cell carcinoma patients: correlation with myelotoxicity and pretherapeutic absorbed dose predictions based on 111In-cG250 imagingAlexander B Stillebroer
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Nucl Med 53:82-9. 2012..The estimated radiation doses were correlated with observed hematologic toxicity. In addition, the accuracy of the predicted therapeutic absorbed doses, based on diagnostic (111)In-cG250 data, were determined...
- Quality of life in patients with gastroenteropancreatic tumors treated with [177Lu-DOTA0,Tyr3]octreotateJaap J M Teunissen
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Clin Oncol 22:2724-9. 2004..To evaluate the quality of life (QoL) in patients with metastatic somatostatin receptor positive gastroenteropancreatic tumors treated with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate) therapy...
- Radiolabeled DOTATOC in patients with advanced paraganglioma and pheochromocytomaF Forrer
Institute of Nuclear Medicine, University Hospital of Basel, Basel, Switzerland
Q J Nucl Med Mol Imaging 52:334-40. 2008..We evaluated the effectiveness and toxicity of radiolabeled DOTATOC in patients with metastatic paraganglioma and pheochromocytoma...
- Hormonal crises following receptor radionuclide therapy with the radiolabeled somatostatin analogue [177Lu-DOTA0,Tyr3]octreotateBart de Keizer
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 35:749-55. 2008..The aim of this study was to investigate the incidence of hormonal crises after therapy with the radiolabeled somatostatin analogue [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate)...
- 177Lu-[DOTA0,Tyr3] octreotate therapy in patients with disseminated neuroendocrine tumors: Analysis of dosimetry with impact on future therapeutic strategyMichael Garkavij
Department of Oncology, Lund University and Lund University Hospital, Lund, Sweden
Cancer 116:1084-92. 2010..In commonly used dosimetry methods, planar imaging is used for determination of the residence time, whereas the kidney mass is determined from a computed tomography (CT) scan...
- Biodistribution and dosimetry of 177Lu-labeled [DOTA0,Tyr3]octreotate in male nude mice with human small cell lung cancerAnneli Schmitt
Department of Radiation Physics, Lundberg Laboratory for Cancer Research, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Cancer Biother Radiopharm 18:593-9. 2003..In this study the biodistribution of a somatostatin analogue, (177)Lu-[DOTA(0),Tyr(3)]octreotate, was investigated in an animal model, as a possible therapeutic radiopharmaceutical...
- [177Lu-DOTAOTyr3]octreotate: comparison with [111In-DTPAo]octreotide in patientsD J Kwekkeboom
Department of Nuclear Medicine, University Hospital Rotterdam, The Netherlands
Eur J Nucl Med 28:1319-25. 2001..Also, labelled with the beta- and gamma-emitting radionuclide lutetium-177, this compound has been shown to have a very favourable impact on tumour regression and animal survival in a ..
- Comparison of [177Lu-DOTA0,Tyr3]-octreotate and [177Lu-DOTA0,Tyr3]-octreotide for receptor-mediated radiation therapy of the xenografted human midgut carcinoid tumor GOT1Christina Swärd
The Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden
Cancer Biother Radiopharm 23:114-20. 2008..Octreotate seems to be a more suitable somatostatin analog than octreotide for receptor-mediated radiation therapy. P-CgA is a simple, accurate method for the estimation of tumor response in this animal model...
- Absolute peptide quantification by lutetium labeling and nanoHPLC-ICPMS with isotope dilution analysisChristina Rappel
Laboratoire de Chimie Analytique Bio Inorganique et Environnement, CNRS UMR 5254, Helioparc, 2 av Pr Angot, F 64053 Pau, France
Anal Chem 81:385-93. 2009..work, a novel approach was developed for accurate absolute peptide quantification based on metal labeling with lutetium diethylenetriamine pentaacetic acid (Lu-DTPA) and nanoflow high-performance liquid chromatography-inductively ..
- Lutetium-labelled peptides for therapy of neuroendocrine tumoursB L R Kam
Department of Nuclear Medicine, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 39:S103-12. 2012..If more widespread use of PRRT can be guaranteed, such therapy may well become the therapy of first choice in patients with metastasized or inoperable neuroendocrine tumours...
- Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclidesWilliam H Miller
Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211, USA
Cancer Biother Radiopharm 20:436-49. 2005....
- Anti-tumor effect and increased survival after treatment with [177Lu-DOTA0,Tyr3]octreotate in a rat liver micrometastases modelWouter A P Breeman
Department of Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Int J Cancer 104:376-9. 2003..177)Lu-DOTA-tate showed anti-tumoral effects in both cases and significant survival in the PRRT-treated rats. (177)Lu-DOTA-tate is a very promising new treatment modality for SSR-positive tumors, including disseminated disease...
- The addition of DTPA to [177Lu-DOTA0,Tyr3]octreotate prior to administration reduces rat skeleton uptake of radioactivityWouter A P Breeman
Department of Nuclear Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 30:312-5. 2003..After labelling [DOTA(0),Tyr(3)]octreotate with (177)Lu the addition of DTPA prior to intravenous administration of [(177)Lu-DOTA(0),Tyr(3)]octreotate is strongly recommended...
- Automated module radiolabeling of peptides and antibodies with gallium-68, lutetium-177 and iodine-131Mario De Decker
Department of Nuclear Medicine, The University of Western Australia, Fremantle Hospital, Fremantle, Australia
Cancer Biother Radiopharm 27:72-6. 2012....
- Production of 177Lu at the new research reactor FRM-II: Irradiation yield of 176Lu(n,gamma)177LuZ Dvorakova
Institut für Radiochemie der Technischen Universität München, D 85748 Garching, Germany
Appl Radiat Isot 66:147-51. 2008..The comparison of theoretically calculated and experimentally determined yield for Lu176(n,gamma)Lu177 reaction is presented...
- Lymphocytic toxicity in patients after peptide-receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE and 90Y-DOTATOCMaribel L Sierra
Nuclear Medicine Division, European Institute of Oncology, Milan, Italy
Cancer Biother Radiopharm 24:659-65. 2009..Since lymphocytes express somatostatin receptors, the aim of this study was to evaluate lymphocytic toxicity after PRRT...
- The potential for induction peptide receptor chemoradionuclide therapy to render inoperable pancreatic and duodenal neuroendocrine tumours resectableT W Barber
Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia
Eur J Surg Oncol 38:64-71. 2012....
- Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogsMarion de Jong
Department of Nuclear Medicine, Erasmus Medical College, Rotterdam, The Netherlands
J Nucl Med 46:13S-7S. 2005..Suitable radionuclides are (90)Y, a pure, high-energy beta-emitter (2.27 MeV), and (177)Lu, a medium-energy beta-emitter (0.5 MeV) with a low-abundance gamma...
- Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applicationsJennifer R Stickel
Department of Radiology, School of Medicine, University of California Davis Medical Center, Davis, California 95817, USA
J Nucl Med 48:115-21. 2007..Though there are other contributing factors, the spatial resolution in small-animal PET is still largely determined by the detector pixel dimensions...
- Tyr3-octreotide and Tyr3-octreotate radiolabeled with 177Lu or 90Y: peptide receptor radionuclide therapy results in vitroAstrid Capello
Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
Cancer Biother Radiopharm 18:761-8. 2003..In conclusion, tyr3-octreotate labeled with 177Lu or 90Y is the most promising analog for PRRT...
- Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PETB J Pichler
Department of Biomedical Engineering, University of California, Davis, CA, USA
Phys Med Biol 49:4305-19. 2004..The readout of densely packed, 10 x 10 lutetium oxyorthosilicate (LSO) block detectors (crystal size 2.0 x 2...
- Optimizing imaging protocols for overweight and obese patients: a lutetium orthosilicate PET/CT studyBenjamin S Halpern
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 6942, USA
J Nucl Med 46:603-7. 2005High photon attenuation and scatter in obese patients affect image quality. The purpose of the current study was to optimize lutetium orthosilicate (LSO) PET image acquisition protocols in patients weighing > or =91 kg (200 lb).
- High-phasing-power lanthanide derivatives: taking advantage of ytterbium and lutetium for optimized anomalous diffraction experiments using synchrotron radiationE Girard
Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale J P Ebel CEA CNRS UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 01, France
Acta Crystallogr D Biol Crystallogr 59:1877-80. 2003Ytterbium and lutetium are well suited for optimized anomalous diffraction experiments using synchrotron radiation...
- Treatment with (90)Y- and (177)Lu-DOTATOC in patients with metastatic neuroendocrine tumorsAndrea Frilling
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Germany
Surgery 140:968-76; discussion 976-7. 2006..The aim of the study was to present clinical experience with (90)Y- and (177)Lu-DOTATOC therapy in the management of NET...
- Prediction of myelotoxicity based on bone marrow radiation-absorbed dose: radioimmunotherapy studies using 90Y- and 177Lu-labeled J591 antibodies specific for prostate-specific membrane antigenShankar Vallabhajosula
Division of Nuclear Medicine, Department of Radiology, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 E 68th Street, STARR 221, New York, NY 10021, USA
J Nucl Med 46:850-8. 2005....
- Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-based whole-body PET/CT scanner with the National Electrical Manufacturers Association NU 2-2001 standardMarco Brambilla
Health Physics Department, Azienda Ospedaliera Maggiore della Carita, Novara, Italy
J Nucl Med 46:2083-91. 2005This article reports the results of performance measurements obtained for the lutetium oxyorthosilicate (LSO)-based whole-body PET/CT scanner Biograph 16 HI-REZ with the National Electrical Manufacturers Association (NEMA) NU 2-2001 ..
- Preparation and preliminary biological evaluation of 177Lu-labelled hydroxyapatite as a promising agent for radiation synovectomy of small jointsSudipta Chakraborty
Radiopharmaceuticals Division bRadiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Nucl Med Commun 27:661-8. 2006b>Lutetium-(177)Lu) is considered to be a promising radionuclide for use in radiation synovectomy of small-sized joints owing to its favourable decay characteristics [t(1/2)=6.73 days, E(beta)(max)=0.49 MeV, E(gamma)=113 keV (6...
- In vivo evaluation of 177Lu- and 67/64Cu-labeled recombinant fragments of antibody chCE7 for radioimmunotherapy and PET imaging of L1-CAM-positive tumorsJürgen Grünberg
Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, Villigen, Switzerland
Clin Cancer Res 11:5112-20. 2005....
- On the preparation of a therapeutic dose of 177Lu-labeled DOTA-TATE using indigenously produced 177Lu in medium flux reactorTapas Das
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India
Appl Radiat Isot 65:301-8. 2007..85 GBq) of 177Lu activity, thereby implying that in order to achieve a single patient dose of 150-200 mCi (5.55-7.40 GBq), 300-400 microg of the conjugate needs to be used...
- Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analoguesYubin Miao
Department of Internal Medicine, University of Missouri Columbia, Columbia, MO 65211, USA
Nucl Med Biol 33:723-33. 2006....
- Effects of therapy with [177Lu-DOTA0, Tyr3]octreotate in patients with paraganglioma, meningioma, small cell lung carcinoma, and melanomaMartijn van Essen
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Nucl Med 47:1599-606. 2006..Here we present the effects of this therapy in a small number of patients with metastasized or inoperable paragangliomas, meningiomas, small cell lung carcinomas (SCLCs), and melanomas...
- Effects of treatment with (177)Lu-DOTA-Tyr(3)-octreotate on uptake of subsequent injection in carcinoid-bearing nude micePeter Bernhardt
Department of Radiation Physics, Sahlgrenska University Hospital, Goteborg, Sweden
Cancer Biother Radiopharm 22:644-53. 2007..The aim of this study was to analyze the effect therapeutic injections of (177)Lu-DOTA(0)-Tyr(3)]-octreotate (DOTATATE) had on the tumor uptake of a subsequent injection with (111)In-DOTATATE in GOT1-bearing nude mice...
- Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigenNeil H Bander
Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Semin Oncol 30:667-76. 2003..Three phase I studies are in progress, two using the beta-emitting radiometals yttrium 90 and lutetium 177, and a third using a cytotoxin (DM1) linked to J591...
- Pharmacokinetics and biodistribution of 177Lu-labeled multivalent single-chain Fv construct of the pancarcinoma monoclonal antibody CC49Subhash C Chauhan
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA
Eur J Nucl Med Mol Imaging 32:264-73. 2005b>Lutetium-177 (177Lu) is a radionuclide of interest for radioimmunoimaging (RII) and radioimmunotherapy (RIT) on account of its short half-life (161 h) and the ability to emit both beta and gamma radiation...
- Lutetium-177-labeled gastrin releasing peptide receptor binding analogs: a novel approach to radionuclide therapyS Panigone
Bracco Imaging SpA, Milan, Italy
Q J Nucl Med Mol Imaging 50:310-21. 2006..This review covers the efforts currently underway to develop new and clinically promising GRP-receptor specific molecules labeled with imageable and therapeutic radionuclides...
- A comparison of high- versus low-linear energy transfer somatostatin receptor targeted radionuclide therapy in vitroTapan Nayak
Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
Cancer Biother Radiopharm 20:52-7. 2005..The somatostatin analog [DOTA(0)-Tyr(3)]-octreotide (DOTATOC) has been widely used to target somatostatin receptor expressing tumors for therapy using radionuclides such as (90)Y or (177)Lu...
- Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cellsTapan K Nayak
Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131 0001, USA
Nucl Med Biol 34:185-93. 2007....
- [(177)Lu]pertuzumab: experimental studies on targeting of HER-2 positive tumour cellsMikael Persson
Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Eur J Nucl Med Mol Imaging 32:1457-62. 2005..The purpose of this study was to analyse whether pertuzumab retains HER-2 targeting capacity after labelling with the therapeutically interesting beta emitter (177)Lu and to make initial characterizations in vitro and in vivo...
- Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177LuHuma Mohsin
Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
Bioconjug Chem 17:485-92. 2006..When labeled with 149Pm, 166Ho, and 177Lu, MeO-DOTA-CC49 has potential for RIT of colorectal cancer and other carcinomas...
- Intraperitoneal pretarget radioimmunotherapy with CC49 fusion proteinDonald J Buchsbaum
Department of Radiation Oncology, University of Alabama at Birmingham, Alabama 35294 6832, USA
Clin Cancer Res 11:8180-5. 2005..This study examined a pretarget radioimmunotherapy strategy for treatment of an i.p. tumor model (LS174T)...
- Molecular radiotherapy with somatostatin analogs for (neuro-)endocrine tumorsE P Krenning
Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
J Endocrinol Invest 28:146-50. 2005..Also, the development of therapy strategies with combinations of different radionuclides and or peptides is of interest as these strategies may provide an increase in therapeutic efficacy in the future...
- (89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximabLars R Perk
Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
J Nucl Med 46:1898-906. 2005..Cetuximab was selected as a model mAb because it abundantly internalizes after binding to the epidermal growth factor receptor...
- Electron- and positron-emitting radiolanthanides for therapy: aspects of dosimetry and productionHelena Uusijärvi
Department of Radiation Physics, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
J Nucl Med 47:807-14. 2006..The aim of this work was to investigate the suitability of electron- and positron-emitting radiolanthanides for radionuclide therapy with reference to dosimetry and production possibilities...
- Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific Affibody moleculeVladimir Tolmachev
Affibody AB, Bromma, Sweden
Cancer Res 67:2773-82. 2007..Thus, fusion with ABD improved the in vivo biodistribution, and the results highlight (177)Lu-CHX-A''-DTPA-ABD-(Z(HER2:342))(2) as a candidate for treatment of disseminated tumors with a high level of HER2 expression...
- Evaluation of 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: influence of the number of chelators on the in vitro and in vivo propertiesKarin Knogler
Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
Nucl Med Biol 33:883-9. 2006....
- Evaluation of combined (177)Lu-DOTA-8-AOC-BBN (7-14)NH(2) GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID miceChristopher V Johnson
Department of Veterinary Pathobiology, University of Missouri Columbia, Columbia, MO, Harry S Truman Memorial Veterans Hospital, Columbia, MO 65201 5275, USA
Cancer Biother Radiopharm 21:155-66. 2006....
- In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancersMichael F Giblin
Research Service, Harry S Truman Memorial Veterans Administration Hospital, Columbia, MO 65201, USA
Nucl Med Biol 33:481-8. 2006..These results demonstrate the ability of 177Lu- and 90Y-labeled ST(h) molecules to specifically target GC-C receptors expressed on T-84 human colon cancer cells...
- Radioimmunotherapy of prostate cancer using 90Y- and 177Lu-labeled J591 monoclonal antibodies: effect of multiple treatments on myelotoxicityShankar Vallabhajosula
Department of Radiology, Division of Nuclear Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York 10021, USA
Clin Cancer Res 11:7195s-7200s. 2005..Fractionated dose regimens may decrease myelotoxicity and increase greater total administered dose. We have studied the effect of two or three treatments of 177Lu-J591 and 90Y-J591 monoclonal antibodies (mAb) on myelotoxicity...
- Results of individual patient dosimetry in peptide receptor radionuclide therapy with 177Lu DOTA-TATE and 177Lu DOTA-NOCChristiane Wehrmann
Department of Nuclear Medicine Center for P E T, Zentralklinik Bad Berka, Bad Berka, Germany
Cancer Biother Radiopharm 22:406-16. 2007..In this study, we compared the dosimetric parameter uptake, half-life (kinetics), and mean absorbed organ and tumor doses of (177)Lu DOTA-NOC and (177)Lu DOTA-TATE...
- 177Lu-antibody conjugates for single-cell kill of B-lymphoma cells in vitro and for therapy of micrometastases in vivoRosana B Michel
Center for Molecular Medicine and Immunology, Belleville, NJ 07109, USA
Nucl Med Biol 32:269-78. 2005..This conclusion, however, may not apply to therapy of macroscopic tumors...
- Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapyHyun Soon Chong
Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois 60616, USA
J Med Chem 51:118-25. 2008..C-NETA rapidly binds both Lu(III) and Bi(III), and the respective metal complexes remain extremely stable in serum for 14 days. (177)Lu -C-NETA and (205/6)Bi -C-NETA possess an excellent or acceptable in vivo biodistribution profile...
- Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186ReAdrienne H Brouwers
Department of Nuclear Medicine, University Medical Center Nijmegen, NL 6500 HB Nijmegen, The Netherlands
J Nucl Med 45:327-37. 2004....
- Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotateMilos Petrik
Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
Anticancer Res 27:3941-6. 2007..The radiochemical purity of radiolabelled peptides and the analyses of rat urine were determined by HPLC and/or ITLC-SG methods. Male Wistar rats were used in the elimination studies...
- Biodistribution of 131I-, 186Re-, 177Lu-, and 88Y-labeled hLL2 (Epratuzumab) in nude mice with CD22-positive lymphomaErnst J Postema
Department of Nuclear Medicine, UMC Nijmegen, Nijmegen, The Netherlands
Cancer Biother Radiopharm 18:525-33. 2003..The biodistribution of hLL2 labeled with (131)I, (186)Re, (177)Lu, and (88)Y was studied in nude mice with subcutaneous human lymphoma xenografts in order to determine the most suitable of these four radionuclides for RIT with hLL2...
- Anaerobic 90Y- and 177Lu-labeling of a DOTA-conjugated nonpeptide vitronectin receptor antagonistShuang Liu
Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA
Bioconjug Chem 14:1030-7. 2003..The anaerobic formulation described in this study is particularly useful for (90)Y- and (177)Lu-labeling of DOTA-conjugated small biomolecules, which are sensitive to the radiolytic degradation during radiolabeling...
- Target burn-up corrected specific activity of 177Lu produced via 176Lu(n, gamma) 177Lu nuclear reactionsK P Zhernosekov
Institut fur Radiochemie, Technischen Universitat Munchen, Garching, Germany
Appl Radiat Isot 66:1218-20. 2008..It is shown that (176)Lu burn-up has to be taken into account to estimate the (177)Lu specific activity related to the total mass or amount of lutetium in the system.
- Preparation and preliminary studies on 177Lu-labeled hydroxyapatite particles for possible use in the therapy of liver cancerSudipta Chakraborty
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
Nucl Med Biol 35:589-97. 2008..Hydroxyapatite (HA) particles of 20-60 microm size range are chosen as the particulate carrier due to its excellent biocompatibility and ease of labeling with lanthanides...
- Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149PmWen Ping Li
Department of Chemistry, University of Missouri, Columbia, MO, USA
Nucl Med Biol 30:241-51. 2003..The biodistribution studies of the NCA complexes with DTPA, DOTA and DTPA-OCT showed that the in vitro model correctly predicted the in vivo stability of the radiolanthanide complexes, with Ln-DOTA > Ln-DTPA > Ln-DTPA-OCT...
- 177Lu labelled polyaminophosphonates as potential agents for bone pain palliationS Chakraborty
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
Nucl Med Commun 23:67-74. 2002..i.)) with rapid clearance from blood and minimum uptake in soft tissues. These studies reveal that 177Lu complexes with the synthesized ligands have a potential use in palliative treatment of painful bone metastasis...
- In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applicationsDiane E Milenic
Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Nucl Med Biol 29:431-42. 2002..Based on these in vitro and in vivo studies, the CHX-A" DTPA ligand should be considered a suitable bifunctional chelate for the radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapy applications...
- Biological comparison of 149Pm-, 166Ho-, and 177Lu-DOTA-biotin pretargeted by CC49 scFv-streptavidin fusion protein in xenograft-bearing nude miceMichael R Lewis
Department of Veterinary Medicine and Surgery, University of Missouri Columbia, Columbia, MO 65211, USA
Nucl Med Biol 31:213-23. 2004..2% ID/g), and (177)Lu (35.4% ID/g) peaked at 1-4 h. Rapid blood disappearance was accompanied by urinary excretion of 59-66% ID within 1 h. Biodistributions of these agents show promise for pretargeted radioimmunotherapy of cancer...
- [177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against gliomaAsa Liljegren Sundberg
Division of Biomedical Radiation Sciences, Uppsala University, Uppsala, Sweden
Cancer Biother Radiopharm 19:195-204. 2004..In conclusion, [177Lu]Bz-DTPA-EGF seems to be a promising candidate for locoregional treatment of glioblastoma due to its high binding affinity, low molecular weight, and ability to target EGFR in vivo...
- 177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliationTapas Das
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
Appl Radiat Isot 57:177-84. 2002..23%/g in femur and 5.23% in tibia at 3 h p. i.), rapid clearance from blood (no activity at 3 h p. i.) and minimum uptake in soft tissues...
- Standardisation and decay data of 177Lu and 188ReU Schötzig
Physikalisch Technische Bundesanstalt, Braunschweig, Germany
Appl Radiat Isot 55:89-96. 2001..The half-lives were measured with ionization chambers, yielding T(1/2)(177Lu) = 6.646(5) d and T(1/2)(188Re) = 0.70848(9) d...
- A stylized computational model of the rat for organ dosimetry in support of preclinical evaluations of peptide receptor radionuclide therapy with (90)Y, (111)In, or (177)LuMark W Konijnenberg
Mallinckrodt Medical, Tyco Healthcare, Petten, The Netherlands
J Nucl Med 45:1260-9. 2004..The aim of this work was to develop a generalized computational model for internal dosimetry in rats...
- Synthesis, stabilization and formulation of [177Lu]Lu-AMBA, a systemic radiotherapeutic agent for Gastrin Releasing Peptide receptor positive tumorsJianqing Chen
Bracco Research USA Inc, 305 College Road East, Princeton, NJ 08540, USA
Appl Radiat Isot 66:497-505. 2008..The method of stabilization should be useful for other methionine-containing peptide radiopharmaceuticals in diagnostic and therapeutic applications...
- Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxiaTapas Das
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India
Bioorg Med Chem 12:6077-84. 2004..88%/g at 1h post-injection) with favorable tumor to blood (4.00 at 1h post-injection) and tumor to muscle (4.63 at 1h post-injection) ratios...
- Lanthanide(III) complexes of bis(phosphonate) monoamide analogues of DOTA: bone-seeking agents for imaging and therapyTomas Vitha
Biocatalysis and Organic Chemistry, Department of Biotechnology, Delft University of Technology, Julianalaan 136, Delft, The Netherlands
J Med Chem 51:677-83. 2008..1 and 11 s(-1) mM(-1), respectively. An in vivo gamma-ray imaging study showed that the (177)Lu complexes of 2a and 2b have a high affinity for bones, particularly for growth plates and teeth with a prolonged retention...
- Radioimmunotherapy of a human lung cancer xenograft with monoclonal antibody RS7: evaluation of (177)Lu and comparison of its efficacy with that of (90)Y and residualizing (131)IR Stein
Garden State Cancer Center, Belleville NJ 07109, USA
J Nucl Med 42:967-74. 2001..With its radiophysical properties similar to those of (131)I, coupled with its facile and stable attachment to mAb, (177)Lu promises to be an alternative to (131)I, and a complement to (90)Y, in radioimmunotherapy...
- Tumour thrombus from follicular thyroid cancer detected by 18F-FDG-PET/CTTamer Ozülker
Hell J Nucl Med 12:66-7. 2009
- Ionic charge, radius, and potential control root/soil concentration ratios of fifty cationic elements in the organic horizon of a beech (Fagus sylvatica) forest podzolGermund Tyler
Department of Ecology, Soil Plant Research, Ecology Building, SE 223 62 Lund, Sweden
Sci Total Environ 329:231-9. 2004..copper, dysprosium, erbium, europium, gallium, gadolinium, hafnium, mercury, holmium, indium, lanthanum, lithium, lutetium, niobium, neodymium, nickel, lead, praseodymium, rubidium, scandium, samarium, tin, terbium, thorium, titanium, ..
- Selective accumulation of light or heavy rare earth elements using gram-positive bacteriaTakehiko Tsuruta
Department of Applied Chemistry, Tohwa University 1 1 1, Chikushigaoka, Fukuoka 815 8510, Japan
Colloids Surf B Biointerfaces 52:117-22. 2006..S. albus can accumulate greater lutetium than other REEs from a solution containing yttrium and eight heavy REEs. On the other hand, A...
- Radiolabeled peptides in oncology: role in diagnosis and treatmentRonald E Weiner
Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington, Connecticut 06030 2804, USA
BioDrugs 19:145-63. 2005..peptides (including (111)In-pentetreotide, Yttrium-90 [90Y]-DOTA-Phe1-Tyr3-octreotide, 90Y-DOTA-lanreotide, and Lutetium-177 [177Lu]-DOTA-octreotate) for the treatment of patients with neuroendocrine malignancy are in progress...
- Gateways to clinical trialsM Bayes
Prous Science, S A, 08080 Barcelona, Spain
Methods Find Exp Clin Pharmacol 25:747-71. 2003..lonafarnib, lotrafiban; Melagatran, melatonin, 2-methoxyestradiol, metreleptin, motexafin gadoliniu, motexafin lutetium; Natalizumab, nelarabine, NO-aspirin, NSC-683864; ONO-6126; Pemetrexed disodium, pexelizumab, pirfenidone, ..
- Nuclear medicine in the detection, staging and treatment of gastrointestinal carcinoid tumoursKjell Oberg
Department of Endocrine Oncology, University Hospital, SE 751 85, Uppsala, Sweden
Best Pract Res Clin Endocrinol Metab 19:265-76. 2005..The most recent compound is (177)lutetium-DOTA-Tyr3-octreotate, which has been applied by the Rotterdam group and has been reported to give partial ..
- Reactions of aromatic N-heterocycles with d0fn-metal alkyl complexes supported by chelating diamide ligandsPaula L Diaconescu
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
Acc Chem Res 43:1352-63. 2010..The comparison between yttrium and lutetium benzyl complexes supported by ferrocene- or pyridine-diamide ligands indicated that similar reactions occurred ..
- Lanthanide complexes of triethylenetetramine tetra-, penta-, and hexaacetamide ligands as paramagnetic chemical exchange-dependent saturation transfer contrast agents for magnetic resonance imaging: nona- versus decadentate coordinationDirk Burdinski
Department of Biomolecular Engineering, Philips Research Europe, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands
Inorg Chem 48:6692-712. 2009..This switch in coordination mode, which is caused by decreasing metal ion radii going from lanthanum to lutetium (lanthanide contraction), has no significant effect on the T(1)-relaxivity of these complexes...
- Photodynamic therapy with motexafin lutetium for rectal cancer: a preclinical model in the dogH M Ross
Department of Surgery, Division of Colon and Rectal Surgery, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19096, USA
J Surg Res 135:323-30. 2006..This study evaluated the safety, tissue penetration of 730 nm light, normal tissue toxicity and surgical outcome in a dog model of rectal resection after motexafin lutetium-mediated photodynamic therapy.
- Rare-earth metal complexes supported by 1,omega-dithiaalkanediyl-bridged bis(phenolato) ligands: synthesis, structure, and heteroselective ring-opening polymerization of rac-lactideHaiyan Ma
Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen, Germany
Inorg Chem 47:3328-39. 2008Monomeric yttrium and lutetium bis(phenolato) complexes [Ln(OSSO){N(SiHMe 2) 2}(THF)] (Ln = Y, Lu) were prepared from the reaction of silylamido complexes [Ln{N(SiHMe 2) 2} 3(THF) 2] with 1 equiv of tetradentate 1,omega-dithiaalkanediyl-..
- A count-rate model for PET scanners using pixelated Anger-logic detectors with different scintillatorsS Surti
Department of Radiology, University of Pennsylvania, Philadelphia, 19104, USA
Phys Med Biol 50:5697-715. 2005..based on pixelated Anger-logic detectors using lanthanum bromide (LaBr(3)), gadolinium orthosilicate (GSO) and lutetium orthosilicate (LSO) scintillators...
- Highly sensitive chelating agents for histochemical staining of rare earth metalsY Sumi
Department of Chemistry, St Marianna University School of Medicine, Sugao, Miyamae ku, Kawasaki 216 8511, Japan
Histochem Cell Biol 112:179-82. 1999..very small amounts of rare earth metals, particularly praseodymium, terbium, dysprosium, holmium, ytterbium, and lutetium. Differentiation of a target metal from interfering metals was achieved using masking agents, polyphosphates and ..
- Radiometals as payloads for radioimmunotherapy for lymphomaGerald L DeNardo
Radiodiagnosis and Therapy, Division of Hematology Oncology, University of California Davis Medical Center, Sacramento, USA
Clin Lymphoma 5:S5-10. 2004..b-emitting lanthanides like those of 90Y, lutetium 177, etc...
- High performance liquid chromatographic studies on lanthanides, uranium and thorium on amide modified reversed phase supportsM Akhila Maheswari
Department of Chemistry, Indian Institute of Technology, Chennai 600036, India
Talanta 72:730-40. 2007..Individual separations of heavier lanthanides, i.e., from gadolinium to lutetium also have been achieved using 4HHBA and B2EHM modified supports...
- Novel neurotensin analogues for radioisotope targeting to neurotensin receptor-positive tumorsFaisal Alshoukr
INSERM, U773, Paris, France
Bioconjug Chem 20:1602-10. 2009..3 peptide is a promising candidate for imaging neurotensin receptor-positive tumors, such as pancreatic adenocarcinoma and invasive ductal breast cancer. Analogues carrying DOTA are being developed for yttrium-90 or lutetium-177 labeling.
- Pre-clinical PET/MR: technological advances and new perspectives in biomedical researchHans F Wehrl
Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Röntgenweg 13, 72076, Tubingen, Germany
Eur J Nucl Med Mol Imaging 36:S56-68. 2009..Especially in small-animal research, where high soft tissue contrast is required, and the scan time as well as radiation dose are critical factors, the combination of PET and MRI would be beneficial compared with PET/CT...
- Structure, stability, dynamics, high-field relaxivity and ternary-complex formation of a new tris(aquo) gadolinium complexAline Nonat
Laboratoire de Reconnaissance Ionique and Chimie de Coordination, Service de Chimie Inorganique et Biologique, Departement de Recherche Fondamentale sur la Matiere Condensee, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 09, France
Chemistry 13:8489-506. 2007..It can form 1:1 and 1:2 lanthanide/ligand complexes. The crystal structure of the bis(aquo) lutetium complex [Lu(dpaa)(H2O)2] has been determined by X-ray diffraction studies...
- Micro insert: a prototype full-ring PET device for improving the image resolution of a small-animal PET scannerHeyu Wu
Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri, USA
J Nucl Med 49:1668-76. 2008..A full-ring PET insert device should be able to enhance the image resolution of existing small-animal PET scanners...
- A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolutionHeyu Wu
Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63110, USA
J Nucl Med 49:79-87. 2008..We developed a prototype system to evaluate the feasibility of using a PET insert device to achieve higher resolution from a general-purpose animal PET scanner...
- Mixed d-f3 coordination complexes possessing improved near-infrared (NIR) lanthanide luminescent properties in aqueous solutionAline M Nonat
School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
Inorg Chem 49:8449-56. 2010..ligand forms kinetically stable complexes, 1·Ln, with lanthanide ions such as Ln = ytterbium, neodymium, and lutetium (formed as a non-IR emitting reference compound), the synthesis and photophysical properties of which are ..
- Interaction between photodynamic therapy and BCG immunotherapy responsible for the reduced recurrence of treated mouse tumorsM Korbelik
Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B C, Canada V5Z 1L3
Photochem Photobiol 73:403-9. 2001..used: Photofrin, benzoporphyrin derivative, tetra(m-hydroxyphenyl)chlorin (foscan), mono-L-aspartylchlorin e6, lutetium texaphyrin or zinc phthalocyanine...
- Preparation of 177Lu-labeled oxine in lipiodol as a possible agent for therapy of hepatocellular carcinoma: a preliminary animal studySuresh Subramanian
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
Cancer Biother Radiopharm 25:539-43. 2010..Oxine or 8-hydroxyquinoline was labeled with (177)Lu obtained by neutron irradiation of natural lutetium. Under optimized conditions, the radiolabeled complex was obtained with yields >98% and adequate in vitro ..
- Development of a new bombesin analog radiolabeled with lutetium-177: in vivo evaluation of the biological properties in balb-C miceP B Pujatti
Directory of Radiopharmacy, Nuclear and Energy Research Institute, IPEN CNEN, Sao Paulo
Cell Mol Biol (Noisy-le-grand) 56:18-24. 2010In this work we describe the first results of radiolabeling with lutetium-177 (177Lu) and in vivo biodistribution and pharmacokinetics studies in normal Balb-c mice of a new bombesin analog (BEFG2)--DOTA-Phe-X-BBN(6-14), where X is a ..
- Photodynamic therapy in the canine prostate using motexafin lutetiumR A Hsi
Department of Radiation Oncology, Virginia Mason Medical Center, Seattle, Washington 98101, USA
Clin Cancer Res 7:651-60. 2001..the feasibility of comprehensive treatment of the canine prostate with photodynamic therapy (PDT) using motexafin lutetium (Lu-Tex) and to evaluate the toxicity and tissue effects associated with this treatment...
- Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapyJarod C Finlay
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 82:1270-8. 2006The in vivo fluorescence emission from human prostates was measured before and after motexafin lutetium (MLu)-mediated photodynamic therapy (PDT)...
- Optical properties of human prostate at 732 nm measured in mediated photodynamic therapyTimothy C Zhu
Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street 2 Donner, Philadelphia, PA 19104, USA
Photochem Photobiol 81:96-105. 2005..Measurements were made at 732 nm before and after motexafin lutetium (MLu)-mediated PDT in four quadrants...
- Spherical core-shell structured nanophosphors on the basis of europium-doped lutetium compoundsYu V Yermolayeva
Scientific and Technological Corporation Institute for Single Crystals, NAS of Ukraine, Kharkov, Ukraine
Nanotechnology 20:325601. 2009..The possible reasons for such a phenomenon are also discussed...
- Optimizing injected dose in clinical PET by accurately modeling the counting-rate response functions specific to individual patient scansCharles C Watson
Siemens Medical Solutions Molecular Imaging, Knoxville, Tennessee, USA
J Nucl Med 46:1825-34. 2005..We apply this technique to patient data and show how it can lead to improved clinical scanning protocols...
- MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imagingYuan Chuan Tai
UCLA, Crump Institute for Molecular Imaging, Los Angeles, CA 90095 1770, USA
Phys Med Biol 48:1519-37. 2003..0 cm and an axial length of 4.9 cm. Each detector module consists of a 14 x 14 array of lutetium oxyorthosilicate (LSO) crystals coupled to a multi-channel photomultiplier tube (MC-PMT) through a coherent ..
Research Grants74
- Low Cost Lu-based Scintillator Crystals for PET ScannersWESLEY HACKENBERGER; Fiscal Year: 2004..Recent development of lutetium (Lu) based oxide crystals for a new generation of fast, high-resolution PET systems has made the situation even ..
- Production of High Specific Activity Lutetium-177Cathy Cutler; Fiscal Year: 2005A separation method will be tested and evaluated to determine the feasibility of providing no carrier added lutetium-177 (Lu-177) for use in radiotherapeutic applications...
- Optical Ceramic Hafnates: New Fast PET ScintillatorCharles Brecher; Fiscal Year: 2006..ceramic scintillator based on cerium-activated barium hamate (BaHfO3:-Ce), strontium hafnate (SrHfO3:-Ce), and lutetium hafnate (Lu2Hf2O7:Ce)...
- Time-of-flight PET for Improved whole-body imagingJoel S Karp; Fiscal Year: 2010..We have developed PET detectors, both lanthanum bromide (LaBr3) and lutetium (yttrium) oxyorthosilicate (LYSO), which have excellent timing performance for TOF as well as sensitivity, energy ..
- Lanthanides as Novel Anti-Arthritic AgentsChristopher Evans; Fiscal Year: 2004..Gd3+), which lies in the middle of the series and has been widely used as a therapeutic agent in rats, and lutetium (Ln3+), the smallest lanthanide...
- Metallofullerene Nanoplatform for Imaging & TreatmentPanos Fatouros; Fiscal Year: 2009..The metallofullerenes can be affinity labeled for molecular targeting and can have lutetium (Lu) or terbium (Tb) substituted for Gd...
- Synthesis via Metal-Catalyzed and Cationic CyclizationsTHOMAS STUART LIVINGHOUSE; Fiscal Year: 2010..that a variety of non-metallocene complexes of the group 3 metals (particularly yttrium, scandium, lanthanum, lutetium and neodymium) are versatile and highly selective catalysts for the intramolecular hydroamination of carbon-..
- Synthesis via Metal-Catalyzed and Cationic CyclizationsTHOMAS LIVINGHOUSE; Fiscal Year: 2007..that a variety of non-metallocene complexes of the group 3 metals (particularly yttrium, scandium, lanthanum, lutetium and neodymium) are versatile and highly selective catalysts for the intramolecular hydroamination of carbon-..
- A Positron Emission Mammography/Tomography Biopsy DeviceRAYMOND RAYLMAN; Fiscal Year: 2006..The choices of scintillator material (Lutetium Oxyorthosilicate) and detector pixel size were based on computer simulation studies and model observer studies...
- BIOMEDICAL APPLICATIONS OF EXPANDED PORPHYRINSJonathan Sessler; Fiscal Year: 2004..The second, to which the generic name motexafin lutetium has been assigned, is being tested in various formulations as a photosensitizer for use in (i) the photodynamic ..
- UWMC POSITRON EMISSION IMAGING ANIMAL FACILITYThomas Lewellen; Fiscal Year: 2005..The recent availability of new, multi-cathode photomultiplier tubes PMTs) and a reliable source of Lutetium Oxyorthosilicate (LSO) crystals has now made it possible to build these systems for general use...
- Multibeam Healing for Laser Micromachining in ManufacturingBIPIN SINGH; Fiscal Year: 2007..of lasers makes them very attractive alternatives to traditional machining methods for brittle materials such as lutetium oxyorthosilicate (LSO) and gadolinium oxyorthosilciate (GSO) used in high-resolution medical imaging...
- Hybrid APD/ASIC Detector Module for Small Animal PETMICHAEL SQUILLANTE; Fiscal Year: 2002..an application specific integrated circuit (ASIC) that is necessary to support new avalanche photodiode (APD) and lutetium orthosilicate (LSO) detector module designed for small-animal PET applications...
- APD BASED PET DETECTOR MODULES FOR BREAST IMAGINGSIMON CHERRY; Fiscal Year: 2003..The proposed detector module will consist of an array of small discrete lutetium oxyorthosilicate (LSO) scintillator elements, optically connected to two APD arrays at both ends...
- A High Performance PET and CT TomographDavid Townsend; Fiscal Year: 2004..by designing and building a high performance PET scanner with integrated CT technology using the new scintillator lutetium oxy-orthosilicate (LSO)...
- Thick scintillation detector with continuous positioning & DOI capability for PETSuleman Surti; Fiscal Year: 2007..Hence, thick continuous detectors have the potential to significantly impact the clinical imaging situation and the resultant patient treatment. ..
- A Time-of-Flight PET scanner for dedicated breast imagingSuleman Surti; Fiscal Year: 2010..Hence, the development of a dedicated, TOF, breast scanner has the potential to significantly impact patient treatment for breast cancer. ..
- A High Resolution and High Sensitivity Dedicated Mouse Brain PET ScannerYongfeng Yang; Fiscal Year: 2010..During the fourth year of the current grant, we have successfully developed both rectangular and tapered lutetium oxyorthosilicate (LSO) arrays with crystal sizes down to 0...
- POSITION-SENSITIVE APD DETECTORS FOR SMALL ANIMAL PETYongfeng Yang; Fiscal Year: 2007....
- New Ligands for Radioimmunotherapy and MRI of CancerHyun Soon Chong; Fiscal Year: 2006..The results of the proposed research will contribute to the development of better drugs for both MRI and RIT, which will greatly enhance clinical exploration of both modalities, and directly benefit cancer patients. ..


text:
What's new in the new Gnome 2.16 desktop?
The changes in Gnome 2.16 are more than cosmetic: the current release sees a leaner and faster version of the desktop.
Just six months ago, when Gnome 2.14 reached the mirror servers, the Gnome developers proved they can set milestones without sacrificing usability. Programs such as the Deskbar applet demonstrate the power of Gnome's underpinnings, providing an attractive GUI that is both efficient and remarkably uncluttered. The latest 2.16 version adds a variety of new features, and there have been major improvements with respect to performance and memory consumption. The Nautilus file manager is just one example; it now benefits from more robust algorithms.
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Tag Cloud
Tool Predicts Which Websites Will be Compromised
Carnegie Mellon researchers say 3 million pages could fall down the phishing hole in the next year.
SSH Key Management Guidelines
The US government rolls new best-practice rules for protecting SSH.
Knoppix 7.4 Released
Klaus Knopper announces the latest version of his iconic Live Linux system.
PHP Attack Puts WordPress and Drupal at Risk
All websites that use these popular CMS tools could be vulnerable to denial of service attacks if users don't install the updates.
Heartbleed Bleeds On
According to a report, many potential victims of the Heartbleed attack have patched their systems, but few have cleaned up the crime scene to protect themselves from the effects of a previous intrusion.
Drone Brain Goes Open Source
DARPA and NICTA release the code for the ultra-secure microkernel system used in aerial drones.
Password Management Services Vulnerable to Attack
Should you trust an online service to store your online passwords?
New Raspberry Pi Adds Two USB Ports
New B+ board lets you build cool things without the complication of a powered USB hub.
Microsoft Grabs No-IP.com Domains
Redmond rushes in to root out alleged malware haven.
Firefox Steps into 3D
New initiative will bring futuristic virtual reality effects to the web surfing experience.


text:
November 27, 2006
Tifton- In the last year, the Patticake House in Tifton has helped provide clothes to more than 300 battered and foster children, now they're asking for the community help with their Suitcases for Kids program.
Executive director Katie Brown knows a trash bag makes a lousy traveling companion. The Suitcases for Kids campaign provides children with two outfits, a pair of pajamas, and a toy to help ease the transition.
"These bags go to children who have been number one removed from their home through either DFACS, law enforcement, etc. Secondly, the children who come through the Patticake House and our sister program, Ruth's Cottage, we are now filling those child's need as well," said Katie Brown, Patticake House Exec. Director.
You can adopt a child and fill a bag or give a monetary donation. The Suitcases for Kids Holiday Adopt a Child Project runs through the middle of December, but the Patticake House needs help all year.
To adopt a child or family you can contact the Patticake House at (229) 382-4141, or you can mail a check to Patticake House P. O. Drawer 1169 Tifton, GA 31793.
Feedback: firstname.lastname@example.com?subject=SuitcasesForKids
P.O. Box 3130
Albany, GA 31706
(229) 446-1010
FCC Public File
(229) 446-4005
EEO Report
Closed Captioning


text:
A suspect has been arrested in a string of car break-ins that occurred in the Woodridge Subdivision in Clearwater, South Carolina.
The suspect has been identified as 42-year-old Brian Lowry, of the 3000 block of Deans Bridge Road, in Augusta, Georgia.
Lowry was arrested in reference to a warrant from the Richmond County Sheriff's Office. He is being held at the Aiken County Detention Center. Lowry is also a person of interest in a string of vehicle break-ins that are being investigated by the Aiken County Sheriff's Office and by the North Augusta Department of Public Safety.
Anyone with information about this crime is asked to contact the Aiken County Sheriff's Office at 800-922-9709. Individuals also should call Crimestoppers of the Midlands: 1-888-CRIME-SC. Callers can remain anonymous and will be eligible for a cash reward up to $1,000.
1336 Augusta West Parkway
Telephone: 706.722.6664
Can't find something?
All content © Copyright 2000 - 2014 Media General Communications Holdings, LLC. A Media General Company.


text:
Legal Ethics
Fla. Bar Probes at Least 35 Lawyers in Alleged Ponzi Schemer's Firm
Posted Jan 14, 2010 7:44 AM CDT
By Debra Cassens Weiss
The Florida Bar is investigating at least 35 lawyers who practiced law with alleged Ponzi schemer Scott Rothstein.
Ethics investigators are probing whether senior lawyers from Rothstein Rosenfeldt Adler made false representations to the Florida Bar when they certified client trust accounts and whether they misappropriated money from the accounts, the Miami Herald (reg. req.) reports.
At least 35 of the lawyers at the now disbanded law firm listed themselves as partners or shareholders in legal directories, although Rothstein and name partner Stuart Rosenfeldt have said they were the only shareholders. Rothstein is expected to plead guilty on Jan. 27 in the alleged $1.2 billion Ponzi scheme.
Florida Bar President Jesse Diner told the Miami Herald that the bar takes the issue very seriously. "The bar is actively investigating and will pursue remedies against anyone who has violated any rules," he told the newspaper. "This investigation didn't stop with Scott Rothstein."
Prior coverage at ABAJournal.com:
Indicted Lawyer Had Nearly 21M in American Express Reward Points
Will Others Be Charged in Alleged $1.2B Scheme By Founder of Fla. Law Firm?
Ex-Attorney Mulls Plea in Alleged $1.2B Scheme as Trustee Sues Firm Partner for $4M
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text:
|March 15 Conference for High School Juniors & Seniors interested in teaching career
Limestone College will host the Upstate Teacher Cadet Conference at its Gaffney campus on Thursday, March 15 from 8:00 a.m.-2:00 p.m.
The conference is open to all high school juniors and seniors interested in a career in education. While there is no charge to attend the conference or for the provided lunch, registration is required and can be completed online .
The conference is a coordinated effort between the Center for Educator Recruitment, Retention, and Advancement (CERRA) and Limestone's Teacher Education Program. CERRA is a statewide organization with a mission to provide leadership in identifying, attracting, placing, and retaining well-qualified individuals for the teaching profession in South Carolina.
"This conference is an authentic opportunity for those who have an interest in an education career to walk in the shoes of a teacher," said Tracie Sweet, Teacher in Residence for CERRA. "When I was a high school student, I was interested in becoming a teacher but wasn't one-hundred percent sure until I participated in the Teacher Cadet Program. Since then, I have taught first grade for ten years, served as a principal, and now have the opportunity to teach future teachers. The Teacher Cadet Program offered me a chance to make a difference in the world and changed my life forever."
Piloted in four South Carolina high schools in 1985, the Teacher Cadet Program has since grown to 170 high schools in the state and serves over 2,500 high school juniors and seniors annually. The primary goal of the program is to encourage academically able students who possess exemplary interpersonal and leadership skills to consider teaching as a career. An important secondary goal of the program is to provide these talented future community leaders with insights about teachers and schools so that they will be civic advocates of education.
Dr. Penelope Saurino, Associate Professor of Education at Limestone and coordinator of the Teacher Cadet Program at Limestone, spearheaded the effort to bring the conference to the Limestone campus. "We have organized the schedule of the conference to include breakout discussion sessions about various topics including the future of technology in the classroom, tips for applying for and receiving the Teaching Fellows Scholarship, and teaching for autistic and special education needs children."
The Teacher Cadet Conference also includes a lineup of guest speakers that reads like a who's who in South Carolina education. The lineup includes:
• Greshman Brown; 2010 Milliken Educator Award Winner
With such a rich tradition of educating some of the most accomplished teachers in the region, Limestone College seems a natural choice to host the Teacher Cadet Conference. Since 2005, 22 graduates of Limestone's Education program have been named Teacher of the Year by either their school or school district, and 23 have been named Distinguished Teachers of Reading.
The Limestone program offers degrees in teacher education in the areas of English, early childhood education, elementary education, mathematics, music, and physical education. The program continues to add new components to its roster of degree offerings. In August, Limestone was approved by the South Carolina State Department of Education to offer an Early Childhood Education degree program and has also just been approved by the South Carolina Department of Education to offer an undergraduate course in middle level curriculum and organization for add-on certification purposes.


text:
A.J. Reed hit his NCAA-leading 21st homer of the year and picked up his Southeastern Conference leading ninth win on the mound, leading Kentucky to a 6-3 series-opening win over Auburn, on Friday night at Cliff Hagan Stadium.
Click here for the original story.
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text:
Beckley's 20th annual Kids Classic Festival kicked off Saturday at Lake Stephens.
It's a week long festival that offers a variety of family activities for the community. The festival kicks off with it's 5th annual Autumn Fest.
One local mother told 59News the best part of having everyone together.
"We are having fun just watching the kids. They are having fun laughing, kids love to laugh and the parents do too. My favorite part is watching them in the water gun battle," Phyllis James said.
The theme for this year is "West Virginia" in honor of West Virginia's 150th birthday.


text:
History of St. Louis Blazers Track Club
Humble Beginnings
Core Principles
"It's more than a running club …"Blazers has always been more like a family than a track club and many Blazers kids over the years still maintain the friendships that started on the track many years ago. Blair Porter, a long-time Blazers' coach, describes it best: "It's been more than just a running club, it's been a place for kids to 'fit in,' have fun, share new experiences and learn lessons about self-discipline, patience, goals, long-term achievement and self confidence. I've always felt like the kids on Blazers learned much more than just how to be a good distance runner. As I continue to know those same kids as adults, it reinforces to me that Blazers is something special."


text:
Like any other week, thousands of people are converging on Las Vegas in hopes of taking home some big money. But this week is a little different. For the 35th year, the World Series of Poker is being played in "Sin City." But you don't have to travel to Vegas to find a game of poker. It may be closer than you thought.
According to the World Poker Tour, over 50 million people across the country play poker on a regular basis. Already the most popular card game, poker is fast becoming one of America's most popular past-times.
This should come as no surprise. Just flip on a TV. It's everywhere, whether it's celebrity poker on Bravo, the World Poker Tour on the Travel Channel or Late Night Poker on Fox Sports Net. But it's not just the cable stations. Poker has even gone network. NBC aired a World Poker Tour event back in January.
Poker's ultimate prize, The World Series of Poker, is underway at Binion's Horseshoe Casino in Las Vegas. Entering its 35th year, a record number of over 2,400 people are playing. That might not sound like a lot, but when incorporate the $10,000 entry fee, that number becomes a little more staggering.
Last year, 839 people entered and it was an accountant, ironically by the name of Chris Moneymaker, who took home first prize, a cool $2.5 million. Moneymaker was an amateur who was entered into the World Series after winning a $40 poker tournament on the internet.
He's just one of thousands who play poker on-line. Dan Goldman of Pokerstars.com, the website that sponsored Moneymaker in the World Series, says they have anywhere from 5,000 to 15,000 at anytime playing on their site. And that's just one of 60 sites around according to Goldman.
The popularity of television poker and online play has sparked the interest of some Lubbock businesses, enough so that at least four known establishments in town host free weekly poker tournaments. "It seems to be the craze anywhere you go. People are talking about it," says Jean Bruns, Public Relations Manager of Copper Caboose.
You can find a game somewhere in the Hub City just about every night of the week. Mondays at Jake's Sports Cafe on 50th Street, Wednesday's on Avenue Q at Copper Caboose and Thursday's at Buffalo Wild Wings on South University.
"We had a lot of people that would leave our place to go home to play poker," says Scott Stephenson, owner of Jake's Sports Café. "Now you don't have someone at home saying, 'Hey, it's late. Send the boys home.' Now you have a restaurant that stays open to one or two in the morning and everyone's welcome. Everyone's invited," adds Johnny Garcia, manager of the Copper Caboose.
"Just about everybody and their brother has card games at their house for whatever reason, but this is the first time we've brought it to a social setting," says Ken Howard, owner of Buffalo Wild Wings. "We had 120 people here on Monday in this backroom that we usually don't use, so it's become a replacement for Monday Night Football for us," says Stephenson.
"I'm a little surprised at the growth in popularity. It's probably more rapid than anything I've ever come in contact with," says Brun. "The reason that the game is so popular is that it's a simple game to understand, but a difficult game to master," says Stephenson.
And as long as people continue to try and master poker, these restaurants will continue to give them that opportunity.
"As long as the guys keep coming, we'll keep having the games. We don't' see any decline in the game anytime soon," says Garcia.
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