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Research Topics
Genomes and Genes
Role of RNA-Binding Proteins in BCR/ABL Leukemogenesis
Principal Investigator: D Perrotti
Affiliation: The Ohio State University
Country: USA
Abstract: Shuttling hnRNPs control the fate of eukaryotic mRNAs throughout their journey from the active site of transcription to that of translation; thus, gain or loss of their function in hematopoietic cells might result in altered hematopoiesis and/or emergence of leukemia. In BCR/ABL-expressing cells, there is a marked increase in the levels of different RNA binding proteins including FUS, hnRNP A1, hnRNP E2 and hnRNP K, four shuttling hnRNPs involved in the regulation of mRNA biogenesis, processing, nuclear export, and translation. Ectopic expression and/or inhibition of the activity of FUS, hnRNP A1 and hnRNP E2 affects the proliferation, survival, and differentiation of normal and BCR/ABL-expressing cells, suggesting that enhanced expression/activity of certain RNA-binding proteins plays an important but as yet unrecognized role in BCR/ABL leukemogenesis. Thus, the objective of this proposal is: 1) To investigate the mechanisms regulating hnRNP E2 and hnRNP A1 expression/function in BCR/ABL-expressing cells. 2) To identify hnRNP A1 and hnRNP E2-associated mRNAs encoding proteins differentially expressed in CML-blast crisis and CML-chronic phase cells. 3) To determine the BCR/ABL-dependent mechanisms regulating the expression/function of hnRNP K and determine whether hnRNP K function(s) is(are) required for BCR/ABL-induced leukemogenesis.
Funding Period: 2003-08-15 - 2007-07-31
more information: NIH RePORT
Top Publications
Scientific Experts
Detail Information
- BCR/ABL, mRNA translation and apoptosisD Perrotti
Cell Death Differ 12:534-40. 2005
- TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cellsRossana Trotta
Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
J Immunol 181:3784-92. 2008..This effect was accentuated in cells overexpressing SMAD3. Collectively, our results indicate that TGF-beta inhibits CD16-mediated human NK cell IFN-gamma production and ADCC, and these effects are mediated via SMAD3...
- Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemiasDanilo Perrotti
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Cancer Metastasis Rev 27:159-68. 2008..Herein, we review current knowledge of PP2A biology and function with particular emphasis on its tumor suppressor activity and possible therapeutic implications in cancer...
- Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemiaShujun Liu
Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
Blood 111:2364-73. 2008..Our results unveil the Sp1/NF-kappaB pathway as a modulator of DNA methyltransferase activity in human cancer and identify bortezomib as a novel epigenetic-targeting drug...
- Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesisAnna M Eiring
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, USA
Blood 111:816-28. 2008..Thus, the complexity of the mRNA/RBP network, together with the discovery of E2F3 as an hnRNP-A1-regulated factor, outlines the relevant role played by RBPs in posttranscriptional regulation of CML development and progression...
- The PP2A inhibitor SET regulates natural killer cell IFN-gamma productionRossana Trotta
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
J Exp Med 204:2397-405. 2007..Thus, SET expression is essential for suppressing PP2A phosphatase activity that would otherwise limit NK cell antitumoral and/or antiinflammatory functions by impairing NK cell production of IFN-gamma...
- FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphomaQing Liu
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA
Blood 111:275-84. 2008..These results provide the first evidence for the potential use of FTY720 as a therapeutic agent in a variety of B-cell malignancies, including CLL...
- FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemiaPaolo Neviani
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
J Clin Invest 117:2408-21. 2007..Altogether, these results highlight the therapeutic relevance of rescuing PP2A tumor suppressor activity in Ph1 leukemias and strongly support the introduction of the PP2A activator FTY720 in the treatment of CML-BC and Ph1 ALL patients...
- CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alphaSteffen Koschmieder
Department of Medicine, Hematology and Oncology, University of Munster, Münster Germany
Blood 110:3695-705. 2007..Because AML is characterized by arrested differentiation, our data suggest the inclusion of CDDO in the therapy of AML characterized by dysfunctional CEBPA expression...
- NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphomaAnnamaria Galietta
Department of Clinical Medicine, University of Milano Bicocca, Monza, Italy
Blood 110:2600-9. 2007..These results identify PSF as a novel NPM/ALK-binding protein and substrate, and suggest that PSF function may be perturbed in NPM/ALK-transformed cells...
- High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiationJi Suk Chang
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH 23240, USA
Blood 110:994-1003. 2007..Furthermore, these findings suggest the inclusion of clinically relevant MAPK inhibitors in the therapy of CML-BC...
- From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the wayDanilo Perrotti
The Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43240, USA
Clin Cancer Res 13:1638-42. 2007....
- ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemiaD Perrotti
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Br J Cancer 95:775-81. 2006..Thus, the combination of PP2A phosphatase-activating and BCR/ABL kinase-inhibiting drugs may represent a powerful therapeutic strategy for blast crisis CML patients...
- Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B StudyPeter Paschka
Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
J Clin Oncol 24:3904-11. 2006..To analyze the prognostic impact of mutated KIT (mutKIT) in core-binding factor acute myeloid leukemia (AML) with inv(16)(p13q22) and t(8;21)(q22;q22)...
- CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activitiesYoung Jin Lee
Dept of Laboratory Medicine, Box 0134, 513 Parnassus Ave, San Francisco, CA 94143, USA
Blood 108:2416-9. 2006..We also show that forced expression of C/EBPalpha or C/EBPepsilon in combination with ATRA treatment has a synergistic effect on survival of leukemic mice compared with either therapy alone...
- Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cellsClara Guerzoni
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson Medical College, 233 South and 10th Street, Philadelphia, PA 19107, USA
Blood 107:4080-9. 2006....
- A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translationMario Notari
Human Cancer Genetics Program, The Ohio State University Medical Center, Columbus, OH 43240, USA
Blood 107:2507-16. 2006..Thus, BCR/ABL-dependent enhancement of HNRPK translation-regulation is important for BCR/ABL leukemogenesis and, perhaps, it might contribute to blast crisis transformation...
- The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET proteinPaolo Neviani
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Cell 8:355-68. 2005..Thus, functional inactivation of PP2A is essential for BCR/ABL leukemogenesis and, perhaps, required for blastic transformation...
- Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patientsA K Samanta
Department of Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
Oncogene 28:1669-81. 2009..These results indicate that Lyn is downstream of Jak2, and Jak2 maintains activated Lyn kinase in CML through the SET-PP2A-Shp1 pathway...


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Mansory modifies the Maserati GT
Famous purveyor of Ugly reworks gorgeous Maser GranTurismo. What could possibly go wrong?
Posted: 13 Jan 2011
And, more good news! If you ask very nicely, Mansory will also colour the wheels in the same hue as the body, giving your car what corporate types refer to as 'joined-up-thinking'.

subset: commoncrawl


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President Barack Obama and Mitt Romney appealed to female voters during Tuesday's presidential debate.
Obama said he signed pay equity legislation for women, while Romney said he hired women for key posts in Massachusetts.
Here is what Oklahoma women are saying about last night's debate.
Romney should have answered the question about getting rid of deductions such as charity contributions, mortgage & education. #kforpolitics—
Lori Watson (@LorielleWatson) October 17, 2012
You haven't moved us forward these past 4 years… Why are the next for years different Mr. President? #KFORpolitics—
Lady Love (@MsLovely405) October 17, 2012
#KFORpolitics Romney doesnt know when to shut up—
Tara LaCh'elle (@ImaShineBright) October 17, 2012
Both candidates suffer from lack of perspective. $200000 is not middle class, and framing the debate at that salary is flawed. #KFORpolitics—
Ashlyn (@AshlynBrooke10) October 17, 2012
#KFORpolitics Mr. President not everyone will be making bank. Low skilled jobs keep bills paid.—
Lady Love (@MsLovely405) October 17, 2012
Wow.. just waiting for one of them to throw a punch.. this is intense. #KFORpolitics #nbcpolitics—
Holly Cuthbertson (@HolllayP) October 17, 2012
#KFORpolitics So what Romney is being cocky? He's putting Obama in his place isn't he? I think it is time for a change. Romney all the way!—
Cari Nichole Orr (@Cari_Berri) October 17, 2012
Didn't feel either candidate directly answered the tougher, more important questions. #nbcpolitics #kforpolitics—
Lori Watson (@LorielleWatson) October 17, 2012
#kforpolitics sounds like he is about jobs alright, let's use immigrants and sweatshops to make the rich richer and not create jobs in usa—
jennifer boyd (@lboydj) October 17, 2012
#KFORpolitics I just want the candidates to tell me their stance and not talk about the other candidate.—
Deanna Coon (@TomGirl42) October 17, 2012
I think when the candidates go over their time limits the mediator should spray them with a water bottle #kforpolitics—
Jade Porter (@jadeporter0110) October 17, 2012
#kforpolitics- when is Romney going to give real details about his tax plan? All I've heard is him beat around the bush with no answers.—
jennifer boyd (@lboydj) October 17, 2012
Romney is trying to win back the vote of the undecided birds out there. #KFORpolitics—
Laci Patton (@Zyg_26) October 17, 2012


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Christian Arno | September 25, 2013 | Comments |
I'll explain what voice search will mean for search engine optimization.
If you've been keeping an eye on future trends, voice search will already be on your radar. If not, be prepared. The increase in voice-activated searches will have a significant impact on the way web users find information and interact with search engines.
Using voice to search might seem a novel concept to those of us used to attracting web traffic via the words people type. However, in many ways it's a natural evolution of the world's growing passion for the mobile web. After all, small touchscreens with even smaller buttons can make typing a challenge – especially on the go.
Yet while mobile users will continue to benefit from the ease of voice search, it doesn't stop there. Google's Chrome browser now offers voice searching for desktop users too. Selling points include the convenience to use away from your desk or when your hands are full, and its usefulness for longer queries. Google also mentions that it's easier to search by voice when you're not sure of a spelling.
Where Google leads, we can of course expect other search engines to follow.
What will voice search mean for SEO?
Search engine optimization for voice search presents new challenges. To deal with them effectively, it's critical to understand and adapt to its differences.
Most notably, the way people talk to a search engine takes us away from the terse language used for typed search. This is reflected in the natural language interfaces of Apple's voice-activated interface for iOS, Siri, and in Google Voice Search. Both are set up to interact in a more conversational way, answering users' questions. In fact, Apple encourages users to "talk to Siri as you would to a person". With each search engine response being limited to a single piece of information, it's also likely that many queries will have follow up questions – just like a real conversation.
This new way of interacting has consequences for search engines themselves. They will need to interpret these conversational phrases and queries, matching them to relevant keywords in the search index. Rather than serving up a collection of search results, their aim is to provide a direct response (e.g. a weather report in response to a question about the weather).
This clearly has consequences for online businesses and brands. With typed search, ranking well involves predicting the keywords people use to search, guided by statistics on search term popularity and competition. Voice search doesn't rely to the same extent on classic keywords. Online businesses and brands need to instead think about what kind of questions might be asked, and how their sites can provide the best response.
Even here, there is another challenge. With search engines aiming to create a conversational experience, the hard fact is that users are less likely to need to click through to a web page for information. This will have an impact not only on search traffic but also on the data that website owners rely on to monitor their search marketing campaigns.
However, there's still a window of opportunity for businesses. The key is to offer a service, product or in-depth information that can't be delivered in a search engine response.
Other considerations for global businesses
Voice search also offers opportunities to multilingual businesses, as the technology is developed to cover ever more languages. Google already supports an impressive 42 languages. In Asia, these include Japanese, Korean, Mandarin Chinese, Yue Chinese, Indonesian, Malaysian, and most recently, Filipino and Vietnamese. The search engine also offers a variant of English optimized for Indian users. Meanwhile, Chinese search engines Baidu and Sogou have created voice assistants with search capabilities for Android.
Given that web users prefer to search in their native language, going multilingual seems a wise move for businesses with markets across Asia or worldwide. Alongside supporting more languages, search engines such as Google are working to refine accent recognition to include even more users. Follow their lead by localizing your content for different regions.
At the same time, bear in mind the benefit of voice search mentioned by Google: it doesn't matter if you don't know how to spell it, as long as you can say it. English-language web content will itself become more accessible to people with a limited knowledge of written English. This could be a good time to make sure your website is clear and easy to understand for non-native speakers, with any alternative languages clearly signposted.
Although voice search is not yet as popular as traditional typed search, expect it to grow in importance. The changes it brings might seem unwelcome from an SEO point of view, but it also brings in opportunities. If your customers want to talk, be ready to listen to them.
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ROFL REALL!!!! you trying to kill me with laughter??
You havw got to finish this :-) Please
Your story is amazing ! I can't wait for the next chapter:)
Keep it coming.
All three chapters are great, keep it coming. Happy New Year!
Yessssss an update. i'm in love with you story and was wondering if you wanted a beta let me know :)
oh man! Cliff-hanger! Oh well cant wait for the next chapter. Although the whole time flux confuses me. Why was he gone for three days in the future and only and few minutes in the past. Its like Narnia all over again!
Just a small note, if naming specific drugs you might want to check what they are/do and not just grab one at random, Ibuprofen is not an antibiotic, its a (mild) painkiller with anti-inflamatory and fever reducing properties.
But How much has already been completed? ^-^ A curous thought just came to mind...maybe I look into it...I know castles aren't really apart of Japanese archetecture but I can't help wander if may be there are some anchent castles about....now thinking about it that is a stupit thought not worth looking up...Beside my random ramboling thankyou for updating I find it funny how they where prettymuch telling Kagome she was crazy in not so many word back at the spring when she was talking to her youkai ^-^ I find crazy people to be a hoot ^-^ hehe
Im so happy you updated keep up the great work!!
kawaii, shippo is sooooo kawaii with his chest puffing up and junk lol
Love it!! Please update soon!
love this story i can jest see kagome as a big puppy. keep theme comeing.
Inuyasha is so dense sometimes. lol Yay Sesshy!
Dog Kagome is cool.
And the Journey Begins ^-^....well the Journy to Sesshoumaru's Shiro at least....but the start of a new chapter in the story of Sesshoumaru and Kagome no? ^-^
Tanx for updating
I like this story very much. I've two bits of advice for you.
You have your 'there' 'their' and 'they're' mixed up.There- location. Ex. Will you move this bag over there for me, please?Their- possesive. Ex. Their bag is the big yellow one.They're- They-are. Ex. They're not going to admit it, but they like the leather bag better.
You also have some places where you're lacking comma usage. Commas when talking to a person and their name is invovled. Ex.1 "Kags, can you help me over here?" Ex.2 "Damn it, Kags!"
These bits of advice will give you better flow.
INUYASHA © Rumiko Takahashi/Shogakukan • Yomiuri TV • Sunrise 2000No money is being made from the creation or viewing of content on this site, which is strictly for personal, non-commercial use, in accordance with the copyright.


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The North Decatur boys basketball team, one year removed from a sectional championship, returns just one of its five starters from last season's sectional tournament lineup.
Despite losing five seniors to graduation, and the return of less than a half dozen players who saw regular varsity time down the stretch, the Chargers are capable of doubling last year's win total of six. North went 6-17, but won the first two sectional games to advance to the championship.
Despite a rare season without seniors on the roster, the sophomores and juniors have shown the coaches that they are ready to step into major roles this season.
Of North's top eight players, six are sophomores.
"I really like the kids that we have coming back," said Nobbe. "I have some experience coming back, even though we're going to be fairly young. Of those six, quite a few of them were able to get some varsity experience last year, which is really great. Hopefully it will be beneficial for us this year. Some of those other kids that didn't were successful and contributed to our JV team. Even though we are young, it's nice coming in this year to have a lot of kids who understand our system offensively and defensively. It's not just a teaching of all new things. It's more of a re-teaching, so that's nice to see."
With the pieces coming together for the Chargers, North is aiming for a return to the sectional championship game and a shot to settle unfinished business.
More in-depth team analysis and a preview of all players will be published Tuesday.
Contact Nick Gonnella at (812) 663-3111, x7003.


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October 12, 2007
Lee County - - A group that serves children with special needs sponsored a night of fun and fundraising Friday night.
The Southwest Georgia Therapeutic Riding Center held Derby Day at Hunny Pot Stables in Lee County.
The center gives children and adults with special needs the opportunity to learn about animals and ride horses as a form of therapy.
Money raised will help participants attend the Special Olympics Equestrian Event.
"We didn't go last year because the year before, it costs us three thousand dollars to go. So its very difficult to do the horse thing at special Olympics. Were going to start going every other year," says Owner Tara Okon.
The riding center is still collecting donations. The money also helps care for the horses throughout the year.
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(229) 446-1010
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Hari Nam Singh will hold a healing event on Monday, November 25 at the Healing Heart Center. For one day only, Hari Nam Singh is offering Sat Nam Rasayan healing sessions at reduced rates.
If you have not yet had the experience of a treatment with Hari Nam, this is the time.
Address your issues with:
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Book a session to feel a whole lot better and initiate the healing process. Then, follow the guidelines that Hari Nam will suggest to you to sustain the effects of the healing. With one session or many, you will be glad you did.
Hari Nam will be seeing clients from 1 – 8 pm. Sessions last 30 minutes. Reserve a time now to secure your desired appointment time. Be sure to include your name and desired time. Your time will be confirmed.


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From the FanPosts -Joel
The title says it all. I just thought I'd put together a page that had the whole draft on it, loaded quickly, and gave key particulars in one place, that I could put on Chiefs on HarryzAims.com , so I'd have it at my fingertips. One of my projects for the summer is to put together quick links to stuff I want to find in a hurry. I hope you don't mind. This stuff, below might be handy when you want to look at the vitals of one of the 2011 draft picks.
Some of the links are to Scouting Reports on WalterFootball. Some are just links to vitals on NFLdraftscout.com. Hope you don't mind. Feel free to chime in on anything, but I'm mainly just sharing a quick page that I'll be using and adding to, for my own purposes. If you like the direction I'm going, give me a heads-up, and I'll peck away at it, trying to put useful stuff in quick and easy reach.
5/16/11 - The draft is well behind us. Enough time for some things to sink in.
Recapping the draft:
|1 - Jon Baldwin, 26th overall, WR, 6'4'', 228 lbs - 1st round is where you look for an elite WR. Known for throwing his teammates under the bus, but his team DID suck. His upside is ridiculous, and he has strong ties to Larry Fitz and Darrelle Revis. Looking for him to drop 8 to 10 pounds. If he can run in the low 4.4s at 220 pounds, he will be a devastating weapon.
|2 - Rodney Hudson, 55th overall, C, 6'2'', 299 lbs - A solid player, most likely the starting C for the next several years. Should be able to come right in and start any interior line position, as needed. All KC did at tackle (so far) is shift D-Lineman Bobby Greenwood to OT.
3a - Justin Houston, 70th overall, OLB, 6'3'', 270 lbs - Reminds folks of Terrell Suggs, and it was Terrell Suggs I kept bringing up as the kind of player I'd like to see coming to the Chiefs. This will give the Chiefs a potent 4-man rush, regardless of which OLB is coming and which is falling back. This is something they haven't really had for their 3-4, since they started hybridizing their 4-3 in that direction.
3b - Allen Bailey, 86th overall, "Rush DT", 6'3'', 285 lbs - Short-term, the idea is to bring him in to play DT in nickel situations, to rush the passer. I'm still trying to figure out just what I think about this guy. I'm trying to get past my preconceptions and just look at the player for what he is. He weighed in at 285 for the combine and Senior Bowl week, where he seemed sluggish. He dropped to 275 for his Pro Day, and looked pretty quick in shorts, for a guy his size, which is what has my intuition telling me "Steve: He's an OLB masquerading as a lineman." But the initial interest in this guy is probably from projected upside as a guy who will "simply shut down the right side of the offensive line with his ability to play the run." (Walterfootball). Nevertheless, my intuition is telling me this might be a guy who will be an unbelievably strong, durable and BIG OLB, when he maxes out his true pound-for-pound power and quickness. They might want him to bring competition to both T-Jax and Dorsey. If he can play in the 290s, all the better. I'll be looking at his situation closely. We may look back at him as a late-3rd steal. We might look on him as a busted reach-for-upside, too stiff to play LB and not suited to play bigger.
4 - Jalil Brown, 118th overall, DB, 6'1'', 205 lbs - Overshadowed by his teammate, Jimmy Smith, this guy just might benefit more from the transition to the pros, where his jamming skills will be of more use than in the college game. He projects as more of a free safety, but considering some of the WRs the Chiefs face, I'm projecting more inverted coverages in certain games, when the Chiefs will want to be able to blitz, and a big, physical jammer might be just the ticket in some of those games. Having DBs who WILL come up and manhandle ANYbody is a big plus, and will put the bum's rush to some of those offenses that are used to passive responses to their tree-sized wideouts. 6'5'' receivers aren't expecting to be bullied.
5a - Ricky Stanzi (On Walter), 135th overall, QB, 6'4'', 223 lbs - The latest of what Pioli reckons will be his annual QB picks. Looks like a good all-around player/athlete, with a head-start on learning pro offense.
5b - Gabe Miller, 140th overall, LB, 6'3'', 250 lbs - Projects as an OLB. Looking at him on film, I see a guy who brings the kind of push that's been missing from the KC D, in spots. He will be joining a large group of wannabe's, with the return of Studebaker, Vrabel, Sheffield, and Hali, and newbie Houston (and POSSIBLY Bailey, but probably not).
6 - Jerrell Powe, 199th overall, NT, 6'2'', 335 lbs - The long-awaited NT pick is finally made. Once the #1 prospect, many pro scouts felt a lackluster switch to 4-3 is an indication of what they can't get out of him at the next level. Much as we all wanted him, and wanted KC to take him much sooner, if picking him was in the plan, this has the look of a project pick. Hard to say, though. I think Romeo Crennel knows how to suit his 3-4 to a player like Powe. I fully expect to see Ron Edwards return, and Bailey and Powe in the wings behind Shaun Smith. Looking to the future, a slightly smaller DE like Bailey might be the perfect pairing with a true 330-lb space-eating NT.
7 - Shane Bannon, 223rd overall, 6'2'', 266 lbs - Taking another TE/FB. Known as a pass-catching FB who BLOCKS. This new approach to the O-backfield is refreshing. The Haley regime has added only guys with solid ball skills, and trained-up Jamaal Charles to expand his repertoire, which is something I always thought was lacking in 'most all of Carl's picks, except for Kimble Anders, who wasn't much on the blocking side.


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PAS is home to two research centers:
- Institute for the Study of Islamic Thought in Africa (ISITA)
ISITA is devoted entirely to the study of Islam and Africa. It connects a vibrant international network of scholars with shared interests in Islam and Africa.
- Research Alliance to Combat HIV/AIDS
REACH is a collaborative program to produce knowledge and recommendations for the development of more effective HIV/AIDS prevention strategies in specific Nigerian communities.


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Police are searching for a suspect in a deadly shooting Sunday night near 73rd Avenue and Mulberry.
The Phoenix Police Department said they found a man shot in the street at 7100 West Mulberry about 7:30 p.m.
The victim was taken to the hospital where he died of his injuries.
The police K-9 unit helped chase down a man who took off running when they got there. But police are not saying whether the man has been linked to the shooting.
No other details have been released at this time.
Stay with cbs5az.com for updates on this developing story.
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Joan Allen harnesses her often cold screen presence to great effect in much of The Upside of Anger. Her alcoholic über-bitch is a force of nature that Allen keeps grounded in real emotions. She is well-matched by Kevin Costner as a low-key rogue full of both selfishness and self-disgust. Their scenes together have a combination of ease and discomfort that could have held together an entire movie. Sadly, director and writer Mike Binder blindsides the audience with a twist ending that undermines everything that came before. Keeping the fact that is revealed at the end from the audience allows Binder to be lazier than he should be with his characters. A better film about a middle-aged woman consumed by anger would figure out how to show that anger simmering below the surface and occasionally boiling over. Binder's facile ending allows him a shortcut that insults the audience's intelligence. With this very game cast, The Upside of Anger could have aimed to be a sardonic Scenes From a Marriage, but Binder is content to settle for something more along the lines of Inside the Mind of the Bitter Married Woman.
by Perry Seibert review


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U.S.-Mexico Border Health Issues
U.S. and Mexican officials spoke about various problems that are unique to the U.S.-Mexico border region. Among the issues addressed… read more
U.S. and Mexican officials spoke about various problems that are unique to the U.S.-Mexico border region. Among the issues addressed at the day-long conference were drug-related violence in Mexico, cross-border trade and commerce, and immigration reform and labor mobility.
Following introductory remarks panelists talked about the Mérida Initiative; a security cooperation agreement between the United States, the government of Mexico and the countries of Central America, with the aim of combating the threats of drug trafficking, transnational crime and money laundering. The assistance includes training, equipment and intelligence. Panelists also answered questions from the audience. close
*The transcript for this program was compiled from uncorrected Closed Captioning.
People in this video
- Bersin, Alan Special Representative Department of Homeland Security->Border Security
- Chrisos, John Vice President American Science and Engineering
- Cuellar, Henry U.S. Representative [D] Texas
- Hinojosa, Ruben U.S. Representative [D] Texas
- Ibarra, Mauricio Attache Mexican Embassy->Special Affairs
- Jacobson, Roberta Deputy Assistant Secretary Department of State->Western Hemisphere Affairs
- McCaul, Michael U.S. Representative [R] Texas
- Palmieri, Francisco "Paco" Bureau Chief Department of State->Bureau of International Narcotics and Law Enforcement Affairs
- Petrie, Suzanne Director TASC Security Services
- Reyes, Silvestre U.S. Representative [D] Texas
- Rodriguez, Ciro U.S. Representative [D] Texas
- Sarukhan, Arturo Ambassador Mexico->United States
- Zapanta, Albert C. President U.S.-Mexico Chamber of Commerce
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The Viking 1 lander which arrived on Mars in July 1976: Scientists now believe there is strong evidence of microbial life in the soil samples analysed by Viking 1
In July 1976, the Viking 1 probe touched down on Mars and failed to find traces of life - but now, three decades later, scientists think the experiment was flawed.
VIking 1 did find evidence of extraterrestrial microbes in soil samples from the Red Planet.
Mathematical analysis of the samples concluded that salts in the soil on Mars 'threw off' initial estimates - and that the soil samples show strong evidence of microbial life.
The new analysis looked for 'complexity' in the samples - an indication of life. To the surprise of the scientists, they found it.
'This suggests a robust biological response,' say the researchers, from the University of Siena and California's Keck Institute. Read More


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Injured Calabar student recovering
BY KIMMO MATTHEWS Observer staff reporter matthewsk@jamaicaobserver
OFFICIALS at the Calabar High School have reported that the student who was stabbed and injured yesterday by men dressed in khaki uniforms is recovering.
Reports are that at about 2:30 pm yesterday, three men dressed as students attempted to enter the school grounds but were stopped by security guards who quickly identified that they were not from the school.
"Reports are that two men came to the school dressed as students and attempted to enter the school compound but were impeded by the school security ," said Canute Fagan, Dean of Discipline at the school.
This led to a confrontation between the men and security guards.
Students at the school who saw what was happening also came to the assistance of the guards.
One student was stabbed and injured during the melee while the three men were held by the police who were quick on the scene," said Fagan.


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The Halton Amateur Radio Club provides our Community with free radio communication services for some of the activities in the area. These services help ensure both the participants' and the public's safety and convenience by providing reliable communications across the venue regardless of scale or terrain.
The following chart shows the clubs commitment to the community. The each bar represents the total number of man-hours for the respective year and is subdivided by activity and the respective man-hours.
(Click Picture For Full Size Image)
Statistics courtesy of Eric, VE3JIT.


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ISA must go!(Photo courtesy of the obnoxious 5xmom)
On 15th Sept I went to Cathedral of the Holy Spirit for a mass and candlelight vigil dedicated to Justice, Peace and Truth Prevail in Malaysia.
In his opening, Fr Fabian quoted opening words of the Vatican II document "THE PASTORAL CONSTITUTION ON THE CHURCH IN THE MODERN WORLD":
"The joys and the hopes, the griefs and the anxieties of the men of this age, especially those who are poor or in any way afflicted, these are the joys and hopes, the griefs and anxieties of the followers of Christ."A powerful message to all christian to stand up and be accountable for what happen in our beloved land.
Under this inhumane law the BN government detains without trial citizens of this country who have not been charged with specific violations of any law in an open court. The continued use of the ISA goes against internationally accepted human rights standards. The use of the ISA makes a mockery of the teachings of Jesus Christ which uphold human dignity and natural justice.
We pray now for all those who are currently detained and for their loved ones; we also remember those who were detained and tortured in the past under this inhumane law.
As followers of Christ and Citizens of Malaysia we must continue to condemn this law and urge the government to repeal it. There is no place for this law on this earth.We must all stand united for freedom of speech and expression within the boundaries of truth and justice. We must reject all attempts to split us along racial and religious line.
"The Spirit of the Lord is upon me, because he has anointed me to preach good news to the poor. He has sent me to proclaim release to the captives and recovering of sight to the blind, to set at liberty those who are oppressed, to proclaim the acceptable year of the Lord." Luke 4:18-19
My father who before this openly supported ISA and think that it is still needed to keep the country safe also went for the special mass. I was surprise to hear that he wanted to go during dinner. Couldn't be prouder, when we stand side by side, singing out loud hyms, together with 'Suara Rakyat' to denouce ISA. "ISA must go, ISA must go now!" we sang in union.
There are few online petitions to call for Abolish of ISA, please read them and sign them if u want to be accounted for the future of our country.
Abolish the Internal Security Act (ISA) in Malaysia
So what do u say my friends?


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Our Houston hotel is the perfect location for your home away from home while visiting Greenway Plaza, the Galleria or the Houston Medical Center. When you book a stay for seven or more nights, you will receive daily high-speed internet access and a 20% discount in our food & veberage outlets (excluding Starbucks®), as well as our in-room dining. If you are looking for a night out, our helpful staff will point you to a selection of great restaurants in Houston.
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KPLC 7News and kplctv.com are pleased to announce the launch of a new and improved news app for smartphones.
The KPLC News app is a FREE news, weather, and sports app featuring local news from 7News. The new app offers more stories and more radar images than our previous app and adds the ability to share and save stories for offline reading in the "My View" section.
In addition, the new KPLC News app allows you to submit pictures and video directly to KPLC ViewerNet in the "My Report" section.
Other features:
Breaking news alerts
Live, local news headlines and stories
Live radar
The new app is available for both iOS (iPhone and iPod Touch) users and Android users. To download and install the free app, search "KPLC" in the App Store or Android Market.
LINK: iOS App Store
LINK: Android Market
Here are answers to some Frequently Asked Questions:
1) What happens to the old "KPLC 7NewsNow" app?
That app is going away at the end of July. You need to download and install the new free app to continue to receive breaking news notifications from 7News.
2) Will the new app automatically replace the old app?
No. You must download and install the new app. You are welcome to delete the old app at any time after downloading the new app.
3) Why do the stories not refresh when I reopen the app?
The app does not automatically refresh when you reopen it. To refresh the story listings on the app, pull the screen down (like you do with the Facebook app) until the screen begins to refresh. You can also manually close the app and relaunch it.
4) Is there an iPad app?
No, not yet. We are working on that and hope to have something available later this year.
5) What about an app for Blackberry?
We are working on that and hope to have something ready in the near future.
6) What about an app for Windows mobile devices?
At this time, we do not have plans to make an app for Windows mobile devices. We encourage anyone who does not have an iPhone, Android device, or Blackberry to use our mobile website, http://m.kplctv.com/.
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40 Year Anniversary Pins!?!
Has anyone seen this available anywhere? I collect pins for my kids and I am surprised with all of the promotions surrounding the 40 year anniversay this year, the A's are not selling this...at least not that I am aware of. I checked all of the gift shops the last time I was up in Oakland for a game. Been checking mlb.com shop. Help?


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What is Adaptation?
Adaptations of narrative works can encompass a range of approaches to source materials that might include editing, rewriting, interpolation, and/or expansion; this adaptation, however, includes every single word of Everything That Rises Must Converge and A View of the Woods. In so doing it retains the narration, characteristic rhythm and power of Flannery OConnors voice. Karin Coonrods script features an approach wherein the narrator and characters words are to be shared amongst an ensemble of eight performers. In making such choices Coonrod highlights the multiple points of view suggested by the narration and explores how they work in concert and/or counterpoint with character discourse and action.
This approachcoined as Chamber Theatre by the director, scholar, and educator Robert Breenoffers invigorating challenges for the director, dramaturg, actors, and designers who will bring the work from page to stage. In staging the stories, Karen Robinson will explore movement choices with the actors that not only bring the narration and characters to life, but offer visual reinforcements of OConnors religious and social themes. Likewise, she looks forward to working with the design team to find compelling visual imagery that interweaves theatricality with OConnors strong sense of place.
Our DRAMATURG answers the question
In theatre and performance studies, adaptation usually implies revising, devising, or interpreting a previously written text for the stage. Implicit to the act of adaptation is the question of authenticity: how faithful (or authentic) is the adaptation to the original piece? Does the adapter (or deviser) capture the intention, or the essence of the source text? This question is fraught with philosophical issues, given the suspicion with which many contemporary scholars view intentionality. Yet it remains a central question to the art of adaptation, since fidelity to the source material (to varying degrees) distinguishes adapting from writing that is inspired by or informed by (but not based on) an extant text.
SCHOLARS answer the question
Chamber Theatre is not interested in the problems of transforming fiction into drama; it resists the temptation to delete narrative descriptions and rewrite summaries as dialogue. No effort is made in Chamber Theatre to eliminate the narrative point of view which characterizes fiction; indeed, the storytellers angle of vision is emphasized through physical representation onstage (Breen 4).
In chamber theatre, a character (usually defined as The Narrator) observes, describes, and analyzes the activities of the other characters (usually identified with proper names) who appear onstage, whereas this critical/voyeuristic role is normally performed by the audience in conventional theatre (Bowman 3).
Borrowing Breens model of adaptation techniques as the foundational structure for a feminist chamber theatre method requires a systematic, critical inventory of its basic conventions. I have organized this inventory around [five] constitutive elements of Breens Chamber Theatre: 1) the use of the narrator and 2) the concept of alienation, 3) the focus on split subjectivity and 4) the use of the mirror to represent this convention, and, finally 5) the relationship between the adapter and the adaptation (Diekmann 42).
As I listen to this [interview with founding members of the Lookinglass Theatre], I recall what I first discovered when studying with Robert Breen: that adaptation is not a timeless theory or set of techniques, but a succession of diverse embodied practices, driven by desire and even desperate neediness. The book I have just readthis book whose scenes have banged off the walls of my ribcagemust be told again to my world, my age. I would tell the story myself, but my lone body is not adequate to supply the visions that the book has projected on my mindscreen. I must extend myself through ten, twelve, fifteen bodies (Edwards 233).
The function of Chamber Theatre is to use the art of the theatre and all its theatrical devices which encourage the illusion of direct apprehension in order to reflect the sort of world which mirrors itself, the world which has already been distorted by the narrative point of view. In short, Chamber Theatre holds an undistorted mirror up to an image of the world which the point of view of the narrator has already distorted in his or her individual glass (Breen 13).
In short, adaptation can be described as the following:
An acknowledged transposition of a recognizable other work or works
A creative and an interpretive act of appropriation/salvaging
An extended intertextual engagement with the adapted work Therefore, an adaptation is a derivation that is not derivativea work that is second without being secondary. It is its own palimpsetic thing (Hutcheon 8-9).
There have been very few adaptations of OConnors work to date. Films include: A Circle in the Fire, directed by Victor Nunez in 1974, The Displaced Person, adapted by Horton Foote and directed by Glenn Jordan, and Wise Blood, adapted by Benedict and Michael Fitzgerald, directed by John Huston. For an analysis of the film of Wise Blood please click here to read KSU professor Dr. David Kings chapter The Film Without Christ: John Hustons Adaptation of Wise Blood.
Works Cited
Bowman, Michael. Novelizing the Stage: Chamber Theatre After Breen and Bakhtin. Text and Performance Quarterly 15 (1995): 1-23.
Breen, Robert. Chamber Theatre. Evanston, IL: Caxton, 1978, 1986.
Dieckmann, Laura. Towards a Feminist Chamber Theatre Method. Text and Performance Quarterly 19 (1999): 38-56.
Edwards, Paul. Staging Paradox: The Local Art of Adaptation. SAGE Handbook of Performance Studies. Eds. D. Soyini Madison and Judith Hamera. Thousand Oaks, CA: SAGE, 2006. 227-253.
Hutcheon, Linda. A Theory of Adaptation. New York: Routledge, 2006.
Zimmerman, Mary. The Archeology of Performance. Theatre Topics 15:1 (March 2005): 25-35.


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Race night supports Pershore Carnival (From Evesham Journal)
Get involved! Send your photos, video, news & views by texting EJ NEWS to 80360 or e-mail us
Race night supports Pershore Carnival
10:48am Tuesday 25th February 2014 in News
A CHARITY race night will take place on Saturday, March 8, at Pershore Sports Club in support of Pershore Carnival.
The event, which is taking place in the run up to the famous Cheltenham festival, will see people raise money for event later this year by betting on eight races.
The night starts at 7.30pm and costs £2 for entry.


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Xanders said they ahve 190 players on their draft board. That's near twice as many as most other teams from what I've read. Obviously a team doesn't put the best 190 players on their board because come the 191st pick in the draft they'll have run out of options as the other teams will have picked up those guys. That's not to say that all teams think the best 190 players are the same. There are over 224 draft picks when you include the compensatory ones. 7 rounds. Many of the players on the Broncos' draft board may not even be drafted. My question is this:
What happens at the end of the 7th round to all the Unrestricted Rookie Free Agents?
Usually there's a mad scramble to sign guys to qualifying offers to find undrafted gems, ala Rod Smith, and or camp fodder. It doesn't look like we can just call them up and get a verbal that they'll be at our camp when the CBA gets worked out. Maybe I missed this topic in another post somewhere. I always looked forward to seeing which players also got called into camp that weren't drafted. Anybody know what the deal is for this?


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Montpelier, Vermont - April 7, 2009
Proponents call it a day more than ten years in the making - the day Vermont lawmakers voted to legalize same-sex marriage - but even after ten years, the state needs a bit more time to make the law a reality. Senate bill 115 does not take effect until the first day of September.
"Well actually I think it was first put at September first because of some initial concerns the Department of Health had in terms of implementation," explains Rep. Bill Lippert, D-Hinesburg.
The state will have five months to prepare new marriage license applications, which will now offer applicants the choice of being the choice of bride, groom, or spouse.
"Really most of the rest of the application will be very familiar to anyone who's seen a marriage license in Vermont," says Lippert.
The license may look familiar, but for soon-to-be-wed couples, the process is not. Michael and Jace Sheppard were joined in a civil union last summer. Now they want to get married and have some questions.
"Yeah I guess, what's the first step?" wonders Michael. "I would imagine there's an application involved."
"Yeah we know we have to get a new license and register for a new license but I'm not familiar whether or not it automatically transfers for the civil union, I'm pretty sure it doesn't," adds Jace.
Couples with civil unions will not automatically be married once the new law takes effect, nor do they have to get married. Those who want a marriage will have to apply for a license with their Town Clerk and have a ceremony. They do not have to dissolve their civil union, but Rep. Lippert says some may choose to.
"This would be to clarify their legal status," he says.
It may seem like a daunting process, but the Sheppards say it is well worth it.
"Now we're going to have to pay for a lawyer and go through all the B.S. just to get that dissolved, that sort of annoys me," says Jace. "But I would pay twice, whatever it takes to get the marriage license knowing that it's going to the state of Vermont that supported us, and to finally have it done between the two of us."
After September first same-sex couples will be allowed to get married, but they can no longer get civil unions. However, the state will still recognized civil unions that have already been performed.
Bianca Slota - WCAX News
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Home training: A basis for survival
The joy of fatherhood: Helpful tips for fathers and men who want to become fathers
by Morris Turner
There are, of course, many different ways to approach the realm of monitoring, directing and responding to the behavior of children. Personally, I frown (heavily) on spanking a child for any reason and have found that "time-outs" and loss of privileges work much better and have true impact on behavior. Perhaps we can explore specific strategies for managing childhood behaviors in a future article; but for now, our focus is to create a mindset that best prepares us as fathers to understand ourselves and the behaviors of our children better.
Here are some tips that other fathers have found helpful:
- Keep up with your child's health care. Issues with eyes, ears, speech or autism could be affecting behavior.
- Be aware of your child's age and maturity. A 2-year-old and a 5-year-old do not see the world in the same way.
- What is your intent? Take time to think about this before you speak with your child. Be loving, clear and brief – don't lecture.
- Always remain even tempered. You may be carrying the stresses of the day inside you, but that is not a load your child should have to bear.
- Don't parentify. Don't use your child as a sounding board for adult issues.
- Think outside the box. When presented with two choices, pause for a moment; a third option may appear.
- Acknowledge, to your child and to yourself, when you learn something from them. If you're not learning, you're not paying attention.
- Continually ask yourself, "Are my expectations realistic?" This will help you to keep growing and learning.
- Never discipline a child while you are "high" or have been drinking. If you do find yourself confronted with this issue, please seek help. Only bad things can happen, and some of them can last a lifetime.
- Your child is not you reincarnated. Let them be their own star, not the one you missed. Remember that it is their first chance, not your second.
Morris Turner is the father of two sons, ages 39 and 35. Over the past 45 years he has worked with children and young people in a variety of settings, including as preschool teacher, career counselor, family mentor and sports coach. He is also an author and recognized researcher in the area of African American settlement in the United States, but his greatest pleasure today is learning to be a good grandpa. He can be reached at firstname.lastname@example.com or by calling (707) 794-0729.


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We loved this deal too, but it's no longer available. Check out our other awesome deals here.
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$11 for Six Whiskey Stones or $20 for 12
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- Don't dilute your whiskey with frozen water. Drink it like a man.
- Grab a set of six whiskey stones from Treasure Steals for only $11 or get a set of 12 for $20.
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GrabOne FaceValue gives you another three months after your coupons expire, making it even easier to enjoy businesses all over New Zealand.
How does it work?
- A coupon is valid up until and including the expiry date printed on the coupon.
- If you don't use it before the expiry date for whatever reason, the coupon retains the value you paid for it for an additional three months.
- This means you can turn up to the business up to three months after the coupon has expired and put the money you spent to buy that coupon towards the service or experience printed on your coupon.
For example, if you spend $50 on a $100 dining voucher but don't use it before the expiry date, you will still be entitled to $50 worth of food and beverage services at that business for an additional three months.
The same goes for coupons without monetary values assigned to them. For example, if you buy a bungy jump deal but don't use it before the expiry date, you can still put the money you spent on the coupon towards a bungy jump, for another three months. Remember, the FaceValue of your coupon can only be put toward the service or experience printed on your coupon.
A few things to note:
- FaceValue applies to all deals that display the FaceValue icon. If the icon is not on a deal, FaceValue does not apply.
- It's always best to use your coupon before the expiry date, so you get the most value for your money. And if you're a bit forgetful, we now automatically remind you if your coupons are about to expire.
- During the FaceValue period, your coupon can only be put towards the service stated on the coupon.
- If the offer is seasonal, like a seasonal menu or chimney sweep service, the FaceValue of your coupon can be put towards a similar offer at the merchant's discretion.
- FaceValue does not apply to product deals, travel and accommodation-related deals, or time-dependent event deals.
- The conditions on your coupon still apply during the FaceValue grace period.


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Tuesday, 07 February 2012 11:58
News & Events - Engineering News
Researchers at the University of Georgia have made strides in the development of a biologically based treatment for broken bones that could reduce the healing process to a matter of weeks rather than months, according to UGA Today.
The work, funded by the Department of Defense, has been spread across several universities including Baylor University College of Medicine, Rice University and the University of Texas, but now researcher at UGA's Regenerative Bioscience Center believe they could take the treatment to a critical next phase.
The new approach makes use of stem cells suspended in a gel that Steve Stice, the director of the RBC, refers to as "fracture putty." This putty is applied directly to the damaged part of the bone where the stem cells produce a protein that is critical to the formation of new bone tissues before dying.
The presence of this protein, combined with appropriate stabilization as is used in traditional approaches, has been shown to dramatically reduce the time needed for healing among mice and sheep. The sheep were able to recover from a fracture in less than four weeks.
Now the approach is being tested on pigs and researchers hope it will be adopted by the UGA College of Veterinary Medicine, which regularly deals with fractures in large animals. This could help move the project closer to human trials.
Though a fracture may seem on its face like a less serious concern for the military, Stice notes that complex fractures of the sort that the new fracture putty could help address are one important cause of amputations among soldiers and many others are forced to deal with months of recovery with limited mobility.
"For many young soldiers, their mental health becomes a real issue when they are confined to a bed for three-to-six months after an injury," Stice noted. "This discovery may allow them to be up and moving as fast as days afterward."
The researchers note that theirs is not the only approach to improving bone regeneration, with others focusing on replacement and the use of new polymers. Medicalxpress.com reports on one team from the University of California at Davis that has developed a means of synthesizing an important protein for bone regeneration, much like the approach at UGA, that can be injected directly.
Another recent success was the implantation of an artificial jawbone constructed using a 3-D printing process.
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May 5th: The night of the robbery?, Mayweather-Cotto/Alverez-Mosley
May 5th: The night of the robbery?, Mayweather-Cotto/Alverez-Mosley
Apr 24 2012, 07:45 PM
Post #11
Junior Welterweight
Group: Members
Posts: 1,247
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Member No.: 11,903
Apr 24 2012, 07:52 PM
Post #12
Super Middleweight
Group: Moderators
Posts: 3,419
Joined: 23-May 11
Member No.: 12,366
Either I wait till 4 am to watch this fight or lye in bed wait for the morning and fight hype will have the headline Mayweather dominates over the course of 12 rounds, and I have insomnia...
Apr 24 2012, 09:38 PM
Post #13
Group: Members
Posts: 12
Joined: 23-April 12
Member No.: 13,638
Mosley is Gatekeeper status at this point. Short of a knockout there is now way he wins this fight. Even if he did who would he fight next? No ones buying a mayweather rematch, ditto for a pacquiao rematch. Forget Berto because if he beats Ortiz there will definitely be a trilogy. If Cotto beats Mayweather u know there's gonna be a rematch there.
Who's left? He'll just be cashing out against a much bigger Martinez and boxing fans will know that, and Chavez Jr. is on a quest to go 80-0-1 against B fighters. I cant see anything but a Canelo victory here.
Apr 24 2012, 11:11 PM
Post #14
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From: Golden State of Mind
Member No.: 13,079
Actually, nothing has happened to "unjustify" the notion that Mosley should be written off since the period just before his fight with Margarito. And no, Mosley's victory over Margarito, although a good one, should not and does not count for much, in my book. I say this because, the moment that handwrap atrocity by Margarito was discovered by Richardson just before the fight and the scandal broke, there was no way Margarito could have surmounted the resulting and towering psychological trauma and win the fight. Forget about Margarito's bravado on that night - or indeed any other night since. Mosley was, in my view, a very fortunate man indeed that night.
As it has since turned out, every subsequent fight since, has further cemented the notion that Mosley is no longer an elite fighter. I don't expect this to change in the course of Mosley's fight with [Canelo] Alvarez.
Canelos chin is not hard to find. He got put down by a less than stellar puncher in Jose cotto. If he let's mosley build any sort of confidences ill say he will be in some trouble if mosley actually shows up trying to win... I know gpb is putting him in there as a stepping stone but what if mosley is looking at it as one last showing before he retires? Ya never know
Apr 25 2012, 11:17 AM
Post #15
"The Meanest Nice Guy"
Group: Moderators
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Joined: 11-May 11
From: Wherever Greatness is Bred
Member No.: 12,050
Forget Berto because if he beats Ortiz there will definitely be a trilogy.
Actually, if Berto beats Ortiz, then it wouldn't hurt him to fight Mosley (in the event that Mosley beats Alvarez). Look at it this way, how many HOFers does Berto have on his resume? *hear the crickets chirping?*
So, fighting Mosley AFTER he beats Alvarez would be perfect timing. This way, it "appears" that Mosley still has something in the tank, and has enough to take on some top B-level fighters...fighters like Berto of course. Berto will be "tested" by a HOFer who has one foot out of the door, but still has enough to compete.
Now, if Shane loses to Canelo, then Berto fighting him, would do him no favors.
He'll just be cashing out against a much bigger Martinez and boxing fans will know that, and Chavez Jr. is on a quest to go 80-0-1 against B fighters. I cant see anything but a Canelo victory here.
Martinez should have been pushing to face Mosley when the iron was still a bit hot...really around the time that Mosley fought Mora. That would have been my suggestion, but I guess money talked somewhere along the line. I believe the only reason Sergio moved up was for money fights and a MW title, and Im sure he could've still made 154.
I dont see Shane moving up to MW, probably not gonna happen. He mentioned a rematch with Margarito or Cotto, but that was last year. He can fight guys like Kirkland, Molina, but overall, you're right, there's not much at 54...maybe a Clottey fight. Not much money there...
Apr 25 2012, 08:09 PM
Post #16
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Member No.: 195
Apr 25 2012, 10:59 PM
Post #17
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Member No.: 13,638
Since when were they fighting at middleweight, and i know its all opinion, but you honestly have cotto as a HOF fighter? I personally dont
Not sure about that. Terry Norris is in the HOF and if u match his and Cotto's credentials, Cotto's are a bit more favorable. Granted, Norris was a good fighter himself.
Apr 26 2012, 05:24 PM
Post #18
Junior Welterweight
Group: Members
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Member No.: 11,903
yea i could see cotto making the HOF
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A Rocky Top stroll
Replace your driver's license online.
Sam is not a blogger but I can't pass this one up: Roadside urine bottles.
A GOP candidate for governor?
The Knoxville Marathon and a possible mistake.
Go advertise at SayUncle. Also read about the terrorist list.
Stupid athlete of the week award.


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Jon Switzer sent down, A. Reyes up and Sheff's knee
LHP Jon Switzer sent back down. More moves to come. #Mets— Mike Puma (@NYPost_Mets) June 24, 2009
Switzer no longer in bullpen. Argenis Reyes has been recalled from Buffalo to take his place: We all knew this time would come. Sheff gets another day off and Evans starts at first. It seems Gary has had a cortisone shot in his knee today. Apparently Sheffield's knee problem is an inflamed bursa sac. Hopefully he can avoid the DL


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By Jennifer Emert - bio | email ALBANY, GA (WALB) - AAA predicts a small spike in gas prices earlier this month will keep some people at home this Fourth of July.
The group expects 37.1-million Americans will travel 50 miles or more next weekend. That's down nearly two percent from last year. AAA believes the rough economy and gas prices near $2.50 might be enough to force some to park their cars and campers. In southwest Georgia, gas prices dropped a little from last week and today drivers told us they'll pack up and hit the road. Janet Nelson is planning a 70-mile trip.
"Well, it's just important to get together with friends and family, it's just an important thing to do," said Janet Nelson.
AAA says while road traffic will be down, air traffic is expected to increase by 5-percent next weekend because of declining airfares.
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Nine days before they will square off in a special US Senate election, candidates Democrat Edward J. Markey and Republican Gabriel E. Gomez failed to woo some audience members at a Boston forum, with several saying they had a hard time finding differences in the candidates' responses.
Markey at several points described Gomez' opinions on certain issues as being the opposite of his own. But Gomez countered that Markey was oversimplifying his positions.


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Chef Payton Curry of Brat Haus shows us how to make some traditional Mardi Gras dishes, including alligator po'boys and a crawfish boil.
Crispy Fried Alligator Po'Boy with Creole Remoulade
(1lb) Crawfish Boil, Red Pots, Corn
Wild Boar Andouille sausage with Alligator Gumbo and Dirty Rice
Alligator Gumbo
2 c dark roux
3 ea green bell peppers, diced
3 ea Vidalia onion, diced
8 ea celery stalks, diced
2 ea leeks, diced and washed
6 ea garlic cloves, minced
2 c chopped tomato
2 ea bay leaves
12 c parsley, chopped
1 t salt
12 t black pepper
12 t cayenne pepper
14 t mace
14 t cloves
1 t file
1 t Worcestershire sauce
1 lb peeled raw shrimp
2 lb Alligator
1 gal stock
2 qts cooked long grain rice
Reheat darkened roux and all all veggies up to the garlic. Stop there. We will add that after 7 minutes.
7 minutes later add the garlic and tomatoes and toast for 3 minutes. Now add the spices and cook for 2-3 minutes. Add 12 of the stock and cook until thickened.
Add alligator and cook until tender then add shrimp when you are 7 minutes out from plating. Season with Worcestershire and more black pepper.
Brat Haus
3622 N. Scottsdale Rd.
Scottsdale, AZ 85251
(480) 947-4006
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Ive been trying to write this post for a long time now. Every time I do, it devolves into a Lindy Ruff post, which is not my intention. But basically, Ruff was a great coach for the scrappy small-market sabres, getting the most out of players coming to Buffalo with a chip on their shoulder. The importance of the Pegula transition can not be overstated. Its the introduction of an entirely new operating model. It effects the way you draft, it effects the players you retain, and it effects the players you bring in. As I have said before, this effects the GM more than anyone else, as it is a completely new set of rules for Darcy to play with. Yet, I see Ruff as the first victim of the switch. The staleness of his coaching message, was secondary to the larger issue that he is just better suited to coach the types of players that Buffalo's old operating model seemed to attract.
Again, this is not a Lindy Ruff post, let me get to the point. With Lindy's dissmissal, the team is more flexible than ever. They are no longer tied to Ruff's system and coaching style. This makes this one of the most dynamic times in recent memory. I think many of us have felt that the Sabres have been stuck in the mud between a truly bad rebuilding team, and a perennial contender. That leaves us in the mix for the final playoff spot, and without a realistic chance of making a true run at the Cup. As I have also said before, I personally feel that Darcy is a pretty savy GM, and has amassed significant organizational assets in recent years. Yet, I think the clock is ticking. He continues to be stuck inbetween the old core and the new. The question is does he think that his big 3 of Vanek, Miller, and Pominville warrant the dedication of his organizational assets to supporting players who could make a cup run a reality, or should he sell 1, 2, or 3 of these pieces to build a contender based around Girgs, Hodgson, Girgs, Ennis, Foligno, Meyers, McNabb, etc. I think it is a good question, and don't necessarily know what I think. Quite frankly, I don't know that I really care one way or the other, but I will say that I think in light of the recent losing, the fanbase would be more open to blowing it up and rebuilding than ever in recent memory.
Next season will be the final year on the contracts of Miller, Vanek and Pominville. Unless something major changes in the next 1.5 season, I would imagine 2-3 of them would likely walk to a contender, and I wouldnt blame them. Miller especially strikes me as a guy who would kill to have a shot at the cup. LIkewise, I think even a sniff would propel him into the all-world beast mode we have seen from him at times in the past. While there was a lot of chatter about his game last year during his apparent concussion, I think his numbers sometimes hide that he is still a top 5 goalie on any given night in the NHL and has been a remarkably consistent preformer between the pipes (in a position that is rife with streaky, head case kind of guys). Clearly, I think the world of the guy, but If he was traded to a contender, I wouldn't even be that upset. To me he is a generational American talent, who will rot on an underperformer unless something drastic happens soon. For the Sabres however, that would create a massive vacuum on the backend, so the return better include a goalie, or pretty amazing talent in return. I think at this point it would take a first rounder + a prospect or player with upside to get me excited about a Miller trade.
No move would say rebuild more than trading Thomas Vanek. HGTV has been All-World this season, putting the team on his back for long stretches. Clearly, Vanek is the best skater on this team at the moment, and his trade value might be higher than ever. The market benchmark would have to be Rick Nash, who garnered an incredible haul for his services (including 2 top six forwards, a top 4 defensive prospect, and a first round pick). The Sabres would not expect the same in return, despite similar career statistics (Vanek is a year older, does not have that power forward size, has had a better team around him, and most importantly could walk at the end of next season.) Yet, at this point the return on Vanek prior to a playoff run would be huge. We would probably expect a 1st round pick, a top six forward, and a very good prospect in return. His pure scoring ability would be impossible to replicate immediately, but If you believe that guys like Grigorenko and Armia will produce at close to 1 PPG in the future, this might be a deal worth making.
Pominville in my opinion is the most expendable of the 3 and would likely garner the least in return. That is not to say he is not a great player and an asset to this team. Yet, he lacks the explosiveness to carry a team in scoring, and is not at all physical. He is the team's captain, but he isn't Rolston's pick or any one else who may fill the coaching spot in the future. From the perspective of a contender looking to buy at the end of this season, you get rock solid scoring depth, quiet leadership, a guy who wont hurt you taking penalties, can play in all situations, and wont be disruptive to team chemistry. Trading Pommer at the deadline might be the least damaging sale Darcy could make, while still building assets for his future club.
To the contrary, Darcy could say, elite scoring and goaltending don't grow on trees, lets sell some of our redundant prospect trail/ young talent and make the amalgamation of random talent into 4 lines and 6 D-Men that are suited to their roles, and could legitamately make a push deep into the playoffs. Personally, I don't think this would be bad, I just think that this is much harder to do in a short amount of time. Also, I think if this is the way you choose to go, this has to be coupled with contract extensions for Vanek and Miller. What you don't want is a repeat of Drury/Briere. Giving up organizational talent for nothing is how organizations get set back. But if I'm Miller or Vanek, I want to see a little assurance that this team has what it takes, besides me, to go the distance.
To this end, the Sabres do have a lot of valuable options. I will continue to harp on the fact that a lack of a natural 2-way centerman capable of winning draws and eating minutes, is killing the team. I like Ennis and I like Hogdson, but to me they are very redundant. If you bring in a 2 way guy, and slide Ennis back to the wing, I think the team is instantly better. Likewise if you deal Ennis for the same kind of a 2-way guy, you are still better off. Other forwards on the roster, to me, won't bring return large enough to make the team better. Guys like Gerbe and Kaleta are worth more in Buffalo than on the market, and you would be selling insanely low on Stafford at this point (Ditto (even a healthy) Lleino). I think the defense if full of guys who could be moved for the right price. I dont think the team is married to anyone outside of Meyers and Ehrhoff. Sekera is probably the best guy for trade value at this point, but I think a lot of people might be surprised by what could be gotten for some of the capable but not wowing guys like Leopold, Weber, Regher, Pardy, Brennan, etc. To me, it is the prospect pool that would get a big deal done. Grigorenko to me should be untouchable, and his medicore tape is likely to make his value less than fair. Girgensons, Armia, McNabb and Pysyk are obviously well regarded, as would be McCabe and Gauthier-Leduc at lesser value but with long term upside. In summary if Darcy believes in his group long term, he makes Ennis, the host of DMen, and much of the prospect pool available and brings in difference makers he believes will get the job done. Also, a top draft pick should be on the table, as last years double dip lets you go one year without adding top-end talent.
After considering all these options, I am personally leaning towards the sell-off. I just think it would take some serious wizardry to get a long term defensive center, other pieces that would significantly improve the team, and at the same time convince Miller and Vanek to stay on board well through the primes of there stand-out careers. If that is the route Darcy and ownerships opts to take, you gotta slide 25 into a top 2 center spot, and let him play out the season. Same for guys like Brennan and McNabb. Need to make the best assessment possible before heading into the draft with multiple picks.


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14 March 2014
US private equity giant Carlyle has teamed up with Moore Capital Management founder Louis Bacon to pick up a majority stake in metals and minerals commodity merchant Traxys Group.
Read full story
18 June 2013
London firm Franklin Templeton Investments has bought out the remaining 80 per cent stake in alternative investment firm Pelagos Capital Management.
21 May 2013
US energy-focused private equity firm Riverstone is reportedly leading talks to invest up to $1bn in a new commodities venture designed to take advantage of a bank lending gap within the industry.
7 February 2013
Kazakh private equity firm Verny Capital has sold its 29 per cent stake in Kazzinc, a zinc producer controlled by Glencore, to Kazakhstan sovereign wealth fund Samruk-Kazyna.
4 February 2013
Australian buyout house Archer Capital has agreed to sell petrol station and oil import terminal business Ausfuel to Puma Energy, an emerging markets-focused subsidiary of Dutch commodity giant Trafigura.
16 January 2013
RRJ Capital, the Hong Kong-based private equity firm set up two years ago by former Hopu co-founder Richard Ong, is planning to buy bonds and shares issued by Olam International – the commodity supplier targeted by short-seller Carson Block.
15 January 2013
New York-based buyout titan Apollo has committed $300m to a strategic partnership with mining investor NRI Management which will see the pair invest in mining properties in established regions around the world, with a primary focus on coal.
14 November 2012
Carlyle has partnered with the private equity arm of Standard Chartered and an infrastructure fund managed by South Africa's Remgro to buy a minority stake in Export Trading Group, marking the Nasdaq-listed buyout giant's first deal in Africa.
11 October 2012
Pacific Road Capital, a Sydney-based private equity firm focused on the global mining and materials industries, has closed its second fund with commitments of $476m.
Baring Private Equity Asia has increased its stake in Manappuram Finance, the gold loan company that is also backed by global growth investor Sequoia Capital.
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this thread needs to reach 1000 posts so we can get a panda forum
this thread needs to reach 1000 posts so we can get a panda forum
The Biggest Event Of the PSD Calendar Is Here!!!
POSTERMANIA 4!!! Come Challenge a fellow PSD Friend
Or Rival to a brawl and see Who the better poster is!!!!!
Need More Details? Click Here or PM me! -Owner Riv
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This thread is amazing. Pandas are adorable.
What was meant for me will be Mine once again... THE CHAMP OF CHAMPS IS BACK
how dare there be a panda thread without commissioner panda.
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Tymathee, that's awesome.
this actually made my day.. all i need to do is open this thread every morning and things will be alright
props to vick27m
"Art was my first major in college but it was too hard, so I majored in math"
Ron Artest
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Found the Ryan brothers while searching for Pandas:
Pandas are so cute
You guys must check out this angry panda commercials lmao! http://www.youtube.com/watch?v=SyRvzeNuqa4&feature=youtube_gdata_player
Panda meat taste good. And panda soup too.
The panda revolution starts here.
Go Braves/49ers!
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Select Area...
Get-away Wall
This is the largest chunk of rock in the canyon. This wall is very obvious if one takes the drive towards Gateway. In KC Baum's book of the area, the only documented route up the discontinuous 1300' face is his route Ancient Wisdom. The formations offers mostly good rock with the usual bands and streaks of poor quality rock. As mentioned in the guide, the cracks do tend to flare quite often and seam out. There is enough rock here to keep you busy for a long time.
Getting There
It is 23.5 miles west of Divide Road. Park as for the Unaweep Seep parking. Walk further west to where the lush vegetation decreases and crossing the river is more manageable.
Climbing Season
1 Total Routes
Featured Route For Unaweep Wall
"That's All I'm Asking For!" 5.11 6c+ 23 VIII- 23 E4 5c CO : Grand Junction area : ... : Get-away Wall
The route�s title comes from a song in "Cannibal! The Musical", a song for the ages and one that was sung particularly often on this adventure. In the end, the route was all that we had asked for. We originally planned to do a new route that went up the longest section of the wall where Ancient Wisdom lies, but after seeing the broken and ledgy profile of the face we opted for the steeper west side that would offer more sustained climbing at the cost of a few hundred feet. This route started off...[more] Browse More Classics in CO
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Floral Print tunics, Flower Print Ladies Tops, online shopping, Printed Clothes, Shop Floral Tops, Tops for Girls
For those of us who love a girly print…. Floral is here to stay. So why not celebrate with a few gorgeous pieces from the Yepme collection….!
Every year around this time, floral prints start to emerge on the fashion scene. It's one of those prints that will never get old, regardless of the year or season. There are various styles on the high street at the moment! From soft delicate and feminine prints to the more bolder and brighter floral prints. It's up to you with how floral you want to go! With this guide, you can learn how to style floral prints in a way that works for you.
Pick a Print
With so many types of floral prints to choose from, it's important to choose a pattern that works with your personal taste and style. Flower designs can range from dainty and delicate to big and bold, each kind carrying its own personality and character.
If you prefer styles that are simple and sophisticated, try looking for a print that features small, miniature flowers. A finer print is not only appropriate for the office and work place, but is a great way to bring in a feminine touch. If you're the type to rock statement patterns, a print featuring larger flowers will work best for you. Look for bright colors, vibrant designs and eye-catching details.
Go Edgy
With the right outfit, floral print can also have an edgy feel. Instead of picking pastel floral, try a larger print in darker colors. As a bonus, these darker floral's can be worn into cooler seasons, too! Another way to give your floral look an edgier vibe is to pair a feminine floral with tougher accessories. Think a floral print dress, or floral print leggings and a black tunic. Mix and match for a look that's all your own!
Whether you're looking for a more relaxed look with floral Kimonos or want to make a statement in a classic floral long dress, there are plenty of options to choose from. Just remember to choose a garment that suits your body type and accessorize well. Even just one accessory is enough to brighten up a outfit. Accessories like jewellery and belts can bring in a light dose of fun to floral. It's a good idea to have several flower patterned accessories in your wardrobe, because you'll never know when your outfit will need a little extra something. Even if you don't plan ahead, a floral accessory is an easy way to add instant style.
So if you want to rock the trend this season then go invest in a floral print! Don't be afraid to experiment! There's a floral print to suit everyone, it depends on how daring you want to be!


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Two weeks after her live-in boyfriend, Robert Martin, was charged with brutally beating her child, 23-year-old Aleesha Wyatt has now been charged with child abuse.
According to Genesee County Prosecutor David Leyton, Wyatt allowed Martin to watch her 3-year-old son, Jordin Parkes, despite having knowledge that Martin had been abusing the toddler.
Martin abused Jordin on more than one occasion, according to Leyton.
On Nov. 1, Jordin was beaten so badly, the 3-year-old was left with bruises covering his entire body. The toddler was rushed to Hurley Hospital where he remains in serious condition.
Leyton said that medical examiners were able to determine that some of the bruises on Jordin's body were inflicted before the most recent abuse.
"It is clear that mom did nothing to protect her child," Leyton explained. "We believe that mom knew boyfriend beat the child."
Wyatt pleaded not guilty to one count of first-degree child abuse.
Judge Herman Marable presided over Wyatt's case in 68th District Court in Flint on Thursday.
Jordin's condition is improving, according to Leyton.
"He is moving in the right direction ... but it's going to be a long road ahead," Leyton explained.
Copyright 2012 WNEM (Meredith Corporation). All rights reserved.


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News: Trinidad James Isn't A One-Hit Wonder, Says T.I.
Thursday, Feb 7, 2013 1:30PM
Atlanta rap veteran T.I. recently discussed the buzz surrounding his city courtesy of Trinidad James' "All Gold Everything" anthem and why the fellow ATL rapper is here for the long haul.
In Tip's perspective, James is what the future of hip-hop could very easily look like.
For T.I., appearing on the remix and video was simply a matter of pride in the city he helped to put on the hip-hop map. "When Atlanta first came out, it made a huge impact on the scene, but it was thought to be something that was gonna be fly-by-night -- here today gone tomorrow, and we withstood the test of time," Tip explained between filming shots. "Trinidad is an example of that new generation of what's next to come, because there's still a lot of talent out here," he said. "He's gonna be one of the ones spearheading the charge to the future." (MTV)
James also recently spoke on tagging Atlanta legends like Tip and Young Jeezy for his "All Gold Everything" remix.
"I did everything A-Town just to show people that I love where I come from. I still do," James said in an interview. "That's why I had to start off the year right, why not do the remix with ATL legends?" (MTV)
Recently, Maybach Music Group's Meek Mill spoke on the buzz behind James' current movement.
"Trinidad James is spitting that fire right now," Meek said in an interview. "He's shining, he's living, he's buzzing fast. He's doing his thing. All love. You know what I'm saying? He's a cool homie. I met him a couple of times, he's a cool boy. He's doing his thing." (Rap-Up TV)
Last month, Def Jam VP of A&R Sha Money XL addressed some fan backlash Trinidad has received but noted how popular "All Gold Everything" is.
"I think it's really still about the music. Trinidad [James] created a record that everyone can say they liked," he said. "No matter how much they make fun of him and mash him up with the jokes, they like the d*mn ['All Gold Everything'] record. Music is music. The formula, when you talk about mixtapes and how you put content out, you have the seed to plant. You create awareness, and you grow. That's a formula we all see. But I think the ultimate part of the formula is that the music has gotta be dope." (HHDX)
Check out the "All Gold Everything" Atlanta remix: