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This coming season, I think the AFC West will be one of the most interesting divisions to watch. I think all teams should be considered a chance at making the playoffs. While it's likely San Diego will win the division, I think the Chiefs, Raiders and Broncos all have a chance to be good this season. Let's take a look at each team's good, bad and ugly.
The Good: Young Talent
The Bronco's have had 4 first round picks in the last 2 drafts, Knowshon Moreno, Robert Ayers, Demaryius Thomas and Tim Tebow. Moreno had a pretty good rookie season last year. While Ayers didn't, he was a DL and we all know how DL take time to develop. Tebow could develop into a great QB but again he will take time. Thomas, while not a Brandon Marshall, will still be good. The Bronco's have laid the foundation for the future with some talented young players.
The Bad: Josh McDaniels Calling The Shots
While the youth movement is all well and good, McDaniels is fooling himself if he thinks you can just gut a team of all older talent and replace it with unproven rookies. Herman Edwards learned that the hard way in KC. McDaniels, in my opinion is a little too young and inexperienced to be a HC.
The Ugly: The QB Position
Tim Tebow could be great. The operative word there being "could". It will take a year to figure out whether he can or not. In the meantime Denver has Kyle Orton who has put up some good numbers but is far from being an elite QB. Then there is Brady Quinn who, maybe if he had some weapons in Cleveland, might have been a success. Otherwise he's nothing special considering Denver cut their number 1 WR and another of their good WR.
The Good: Their Offseason
Al Davis looks like he has finally loosened his stranglehold on the Raiders organization and started to take into consideration the opinions of his scouts. He seemed to have made right choices in the draft by taking Rolando McClain and Lamar Houston. Davis has also conceded defeat on Jamarcus Russell.
The Bad: The QB Position
While Jason Campbell is an improvement over Russell he still is by no means a great QB. He didn't excel in Washington where he had average protection. How is going to fare in Oakland with below average protection?
The Ugly: The WR Position
Jason Campbell needs a true #1 WR to make him great. That is something the Raiders lack. Louis Murphy is a #2 WR. Darrius Heyward-Bey is a very fast guy who may or may not be able to make it in this league. Outside of TE Zach Miller, Jason Campbell lacks a go-to-guy.
The Good: Coaching
Todd Haley looks like he has got the full support of the players and has installed a winning attitude into them. The Chiefs then went out and got 2 great coordinators in Romeo Crennel and Charlie Weis. While both of these guys have had poor records as HC their record as DC and OC, respectively, is very well respected.
The Bad: The WR Position
Chris Chambers should have another 1 or 2 good years. Beyond that is unclear. Dwayne Bowe could be #1 WR for his team. His recent media gaffes have hindered the chance of the Chiefs being his team. This is an important season for him. If he can't return to his 2008 form he may be shown the door.
The Ugly: The Front Seven
Outside of 5th round pick, Cameron Sheffield, The Chiefs didn't add a pass rusher this offseason. This is an area of need for the Chiefs. NT is similar in that the only addition was Shaun Smith who may or may not be great. The Chiefs were obviously hoping Romeo Crennel can make something of the 4 1st round picks that the Chiefs have in the front seven before they go and spend another high draft pick on a LB or DL.
The Good: Phillip Rivers
What is there to say? Rivers is one of the best QBs in the league. He can dominate opponents and was the key behind the Chargers 13-3 record in 2009. He will continue to be a dominant QB in the league.
The Bad: The Defence
The loss of Jamal Williams and Antonio Cromartie will hurt their defence. Shawn Merriman's production keeps falling as does his interest in the Chargers. He remains with the team thanks to a franchise tag contract. He may also be out of the Chargers at season's end if he doesn't increase his level of play.
The Ugly: The Choking History.
The Chargers have been one of the league's biggest chokers and that was clear last season after a shock loss to the New York Jets in last season's playoffs, after going the regular season 13-3. The Chargers are still the biggest chokers in the league and there window of opportunity is closing fast on a Super Bowl. The Chargers boasted the explosive offence of Rivers, Vincent Jackson, LT, and Antonio Gates and couldn't get it done.
The Chargers look as though they will probably be taking the AFC West crown again. That being said, Oakland, Denver and Kansas City all look like they could be contenders in the coming years. This is a "go for broke" season for San Diego. I see it as their last realistic chance at a deep playoffs run. If Oakland can keep running things the way they are now, they could be very impressive in the coming years. Denver has a chance, but serious improvements need to be made from their young talent if they are going to stay the course. Kansas City is not without a chance at the playoffs but Romeo Crennel needs to make something out of the Chiefs front seven and Matt Cassel needs some solid improvement from his 2009 season.
1st San Diego Chargers
2nd Kansas City Chiefs
3rd Oakland Raiders
4th Denver Broncos
San Diego should be looking at about a 10-6 season. They will have a little slow down, but not enough to cost them the division.
There won't be much separation between Kansas City and Oakland. Both will probably be around the 8-8 mark. They have both made the moves to make them a better team, but not enough to make them a great team, not yet at least.
Denver will fall to around the 5-11 area. Their Passing game won't be nearly as good and Moreno will be forced to carry the ball more
Let me know your thoughts on the AFC West in the 2010 season


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You're a bully. You're violent and threatening. You want to silence your opponents and stamp out freedom of speech.
Your demands are excessive, grossly unfair, and threaten the good of society. Recognise yourself? Or any gay person you know? Does this description even sound like any gay rights activist you know of? No? Are you absolutely sure? Because this is precisely how gay people today are being portrayed. This is the new backlash.
As Britain reaches the finishing line of gay legal equality, the fear this provokes in those who believe we should remain second class citizens is turning to hysteria, paranoia and frenzied attacks.
Their weapon is the media. Their tactic is simple but explosive: paint gay people as bullies. Like the word "paedophile", "bully" is so effective in provoking immediate contempt as to bypass analysis or questioning. Brand someone a child abuser, a rapist, or a bully and you've won the PR war. This isn't mud sticking; it's anthrax.
And the queen of this dirty campaign? Melanie Phillips. The Daily Mail columnist recently described gay people who believe in equal rights not just as "bullies" but as "totalitarian" "McCarthyites" who subject their opponents to "victimisation" rendering them "petrified" and who are guilty of "bigotry in reverse".
But here's the real reverse bigotry: in one of Phillips' wild tirades, she lashed out at the government's plans to allow gay people to be married in places of worship. The key word in that sentence is "allow". Whereas the proposals seek to give religious institutions choice and freedom, Phillips and several fundamentalist organisations seek to prevent that choice. That is totalitarian. That is the forceful imposition of an ideology – the very accusation slung at us.
The bully label is being slapped on us from much closer to home than just newspapers though. In December, the Oscar-winning actor Kevin Spacey equated being asked about his sexuality to the bullying that leads gay teenagers to suicide: "I feel I have just as many rights not to be bullied as they do." So, just to be clear, gay people who dare to ask Spacey whom he's attracted to aren't just bullies but are as monstrous as those who cause people to kill themselves?
And if we dare to complain about being bullied ourselves? The right wing press kicks us again. Last year, John Witherow, the editor of the Sunday Times, responded to Clare Balding's complaint against AA Gill for calling her a "dyke" thus: "Some members of the gay community need to stop regarding themselves as having a special victim status… a person's sexuality should not give them a protected status." You see? The truth – that we simply want equal rights – is distorted into a pernicious lie: that we want extra rights; that we're brats making outrageous demands.
Certain fringe religious factions aren't content with calling us bullies or brats in their version of the backlash; they write fanciful horror stories about what a future of equal rights would look like. Andrea Williams, head of Christian Concern, said about the aforementioned marriage proposals: "We may well see churchmen… being dragged through the courts for refusing to marry homosexuals and sanction their behaviour." The government has categorically stated that the law won't force anyone to do anything. By why let the truth get in the way of muck-spreading?
Williams also recently described gay people who campaign against therapists attempting to "cure" gay people as "militant". It's an oft-used description of gay rights activists, but it is another defamation. The word means that someone is prepared to use violence. I campaign against so-called conversion therapy and am a pacifist, yet these fundamentalists brand me – and anyone who agrees with me – militant.
But this is all homophobes have left: lies and smears. It's the final paroxysm of a desperate, discredited group. Their prejudices have been held up to scrutiny, and with daylight shining through, everyone with even a vague grasp of logic can see the inherent illogic – that their objections aren't based on fact but fear.
What's so astonishing is that Phillips et al don't for a moment recognise that their beliefs are merely the manifestation of an irrational fear of homosexuality. But everyone else knows this because opponents of gay equality, like children in the dark, imagine what isn't there: gay monsters who want to take over the world and destroy it.
I suspect that deep down our haters know that everyone deserves equal rights, but their angry, loathing minds, riddled with selective verses from the Old Testament, rail against this. They continue to fire word missiles because they're conflicted. All we can do is repeat again and again the simple truth: that we want to be as free and protected – no more, no less – as everyone else.
In the meantime homophobes' inner turmoil continues to burn. As the psychiatrist Dr Max Pemberton said to me recently, "Homosexuality is not a pathology, but homophobia, given that it's a phobic condition, is." Those who wish to tarnish us with slander and slurs, therefore, urgently need psychological help.


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March 02, 2013 at 20:33 PM EST
Nassim Taleb, Stan Druckenmiller talk crisis on Bloomberg TV
Our future may be a bit more fragile than "Anti-fragile", if the latest warnings from Nassim Taleb and Stanley Druckenmiller prove correct.
The pair recently sat down with Bloomberg TV to voice their concerns over America's social and economic strains. Taleb believes we are still loaded down with the unsafe systemic risks and toxic leaders of our recent past. Druckemiller sees a crisis "worse than 2008" ahead.
We have their full interviews for you here, so let's jump right in.
Nassim Taleb
feels we are at a point where we have not learned or benefited from the mistakes of our recent financial crisis. This has made our society more susceptible to fragility and will deepen the effects of future crises.
Moral hazard has increased as bankers have paid themselves larger bonuses with our (taxpayers') money.
Quantitative easing has lifted asset prices.
Median incomes, and the average person's standard of living, have been dropping
while the top tier of society ("the 1 percent of the 1 percent") has been absorbing the lion's share of recent economic growth.
As Taleb puts it, we are now paying for the bad debts and disastrous trades made by irresponsible, bailed-out parties in the last cycle. We have transferred private problems and failures into public problems by transforming private debt into public debt.
In order to improve our situation and ensure future prosperity, we need to face our mistakes and make our regulations and tax codes
complex. Complex regulations are a boon to lawyers and big businesses who game the laws to their benefit. To quote Taleb, we need "sound, minimal regulations and
more skin in the game
(personal liability) for those who make mistakes.".
Recently retired from running public money, star hedge fund manager,
Stanley Druckenmiller
has stepped back into the spotlight to warn of a looming entitlement spending crisis in the USA.
"Every once in a while, the world of investing and what's going on in the country will intersect".
Druckenmiller recounts his conversations with US officials about previous storms on the financial horizon. Based on his past experiences, he figured it was better to keep quiet and manage his investors' money than get caught up in public debates over politically sensitive issues, like the fallout from the 2000s housing bubble.
He now feels he needs to speak out to warn citizens about a
coming bust of America's demographic bubble
. Druckenmiller notes that in 2030, the average population of the USA will be older than the average Floridian is now. "I don't know about the timing of when markets will respond to this, but I know it will happen based on the fundamentals.".
Stan also offers his thoughts on the valuation of the equity markets, bonds, risk assets and zero rates, and competitive currency devaluations. "Every single major country is now running stimulative monetary policies, basically modeled after the Fed.".
One great piece of investing advice from Stanley Druckenmiller (and a recurring theme in this interview): "You've got to think in an open minded fashion and look out into the future to judge companies [and stock prices].
Try and imagine the world 18-24 months from now
and not the way it is today. Then think about where securities prices will be to reflect that view".
Related posts
Nassim Taleb on Antifragile at Google
Jim Rogers on Street Smarts and outsized returns
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Welcome to the Dartmouth MCB Program
We are an interactive and collegial community of scientists dedicated to innovative, world-class research. In this environment, we train our diverse student population to become precise and creative thinkers who impact science and society.
MCB Events This Week
- MCB Research In Progress (RIP) presentations will begin on September 4.
August 18 - 10:00 a.m. - Borwell 658W
Dr. Lihui Zhao - Northwestern University Feinberg School of Medicine
Effectively Selecting a Target Population for a Future Comparative Study
Biostatistics Seminar (RSVP to Lamar Moss)
August 19 - 2:00 p.m. - Auditorium E, DHMC
Jillian Pattison - Thesis Presentation
Classification of Chromatin Architecture and cis-Regulatory Enhancers in Oncogene Biology
Genetics Thesis Presentation
Advisory: Michael Cole
August 20 - 10:00 a.m. - Vail 614
Allia Kaye Smith - Thesis Presentation
Small Molecule Modulation of Morphology and Metabolism in Candida albicans
Micro/Immuno Thesis Presentation
Advisor: Deb Hogan
August 20 - 3:00 p.m. - Vail 614
Julia Koehler, M.D. - Harvard Medical School
Candida albicans pescadillo Controls Cell Cycle Progression and Translational Activation in Response to TOR
Micro/Immuno seminar
Host: Allia Smith
August 21 - 4:00 p.m. - Chilcott Auditorium
Michael J. Ragusa, Ph.D. - Dept of Chemistry, Dartmouth College
The Molecular Mechanisms of the Initiation of Autophagy
Biochemistry seminar


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Because today should be a national holiday and I love this blog so much, I have decided to open the off-day, off-topic thread on a very important note.... It is my Birthday and I am stuck at work... YAY. I hope y'all will share in this day by providing your witty, snarky, humorous, wierd and otherwise insightful comments with me... I will start off the thread with how my weekend was and we'll see where we go from there.
Friday was an off-day for us here in England. Beautiful! Got to finish my paper (as some of you have read) for my master's degree and as of this morning, it is official. I have my Masters Degree!!!! Before you ask, because I know you care.... It is a Masters of Aeronautical Science w/ a Specialization of Human Factors in Aviation. Sounds wicked right? It's really not that special, but it's done. I also go to go see X-Men: First Class friday. AWESOME AWESOME movie. I highly recommend it. You won't be disappointed. Unless you're an X-Men purist junkie who has no other purpose but to cry about how the characters don't stay 100% true to the comics... But y'all can bite me. :-P
Saturday was a London day. Wife and I went down to the west end and watched Wizard of Oz and Shrek The Musical. Both were fantastic. I LOVED Andrew Lloyd Webber's interpretation of Oz. Great fun and then Sunday was our standard Carvery for lunch then we saw Kung Fu Panda 2. Super cute. I don't have kids but I'd let them watch it and it is funny for kids and adults. Of course, not as great as the first but it wasn't bad at all. Which brings me to the last piece of my OD/OT input...
Are there any theaters in the states that do an unlimited card? We have that over here in England at the Cineworld. You spend 14 pounds a month and you get to go to all the movies you want (surcharge for 3D, of course). My wife and I LOVE movies so this works out quite well and saves us tons of money and I'm not sure if it's caught on in the states. If not, I hereby decree as your TC President that we start a petition of Wynsong, Regal and all the other movie theater franchises out there to get one.
Thanks for listening to my Birthday Ramble and let's have a great OD/OT chat today. :-D


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LOUISVILLE, KY (WAVE) - Eight Kentucky Air National Guard members, including some who saved other soldiers' lives, received honors Sunday for their service in Afghanistan.
Maj. Gen. Ed Tonini, Kentucky's adjutant general, presented the medals at the Air National Guard base in Louisville.
"These are eight people who did extraordinary things," Tonini said. "They're all heroes."
Seven Guard members received a Distinguished Flying Cross, a Bronze Star, or an Air Force combat action medal. One member, Technical Sgt. Robert Bonello, earned two Bronze Star medals.
In one battle, Bonello directed an attack on Afghan insurgents while they fired at his unit for three hours. Bonello's actions saved other soldiers' lives and led to 16 insurgent deaths.
"You think about all the guys who were there with you, pushing through and making it happen," Bonello said after the ceremony. "The biggest takeaway is, we couldn't do this without each other."
U.S. military officials have mobilized Kentucky National Guard members 1,600 times since the beginning of the war in Afghanistan after the Sept. 11, 2001, terrorist attacks, Tonini said.
Kentucky's numbers include both U.S. Army soldiers and Air Force airmen, he said.
Technical Sgt. Jeff Kinlaw received a Bronze Star on Sunday for his work in a 14-hour firefight with Afghan insurgents, a battle during which he killed 18 enemy fighters.
"I just felt very proud to have my family and my friends here (for the ceremony)," Kinlaw said.
Capt. Nathan Tingle, a combat rescue officer, was the only recipient of the Distinguished Flying Cross, for heroism during a combat flight.
Tingle helped saved two soldiers who were ambushed with improvised explosive devices in an Afghan minefield in 2011.
"It was obviously a pivotal point in my deployment," Tingle said. "I try not to think about awards and decorations, we're just out there to do the job."
The full list of Louisville-area award recipients:
Copyright 2014 WAVE 3 News. All rights reserved.
When Phil Laboon's relationship ended before his wedding day, he held his reception anyway in the name of charity.
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Women becoming priests without Vatican's blessing
By Maria L. La Ganga, Los Angeles Times, May 25, 2013
SAN FRANCISCO—The priest will be ordained in a purple Lutheran church. The Communion bread, symbolizing the body of Christ, will be gluten-free. The congregation will pray to "our mother our father in heaven."
But the real departure from Roman Catholic tradition will be evident when Maria Eitz approaches the altar Sunday for the laying on of hands that turns parishioner into priest.
Over the last decade, as the Vatican has faced a serious shortage of priests, a small but growing number of women have answered what they believe to be a call from God. California is home to more ordained Catholic women than any other state. Eitz—a retired theologian with four adopted children—will be the first woman ordained as a Catholic priest in San Francisco.
The more than 120 women worldwide who have been ordained as Roman Catholic priests and deacons say their faith gives them comfort and hope. But that same faith also is bound by Canon Law 1024. Short and blunt, the church edict states that "a baptized male alone receives sacred ordination validly."
The Vatican has said that women who presume to be priests, and those who help them, are committing a grave sin. And like Catholics who have abortions or commit heresy, female officiants are subject to the ultimate penalty—automatic excommunication. The church does not acknowledge ordained women or the sacraments they offer.
The first female priests were ordained in 2002 on a boat on the Danube by a bishop who previously had broken ranks with the Vatican. A year later, bishops who asked to remain anonymous until after their death for fear of reprisal ordained the first female bishops so that they, in turn, could ordain other women.
According to Roman Catholic Womenpriests-USA Inc., more women are expected to be ordained as priests and deacons in 2013 than in any previous year.
To Eitz, the threat of excommunication is meaningless. It has happened to her once already, when she became a deacon in 2012. She ignored it then and ignores it now, she said, because "if you are baptized, you cannot be unbaptized. If you are called to the table that God calls people to, you cannot be excluded."
The soft-spoken 72-year-old said she was taking the controversial step because "it is right and just."
"It needs to happen. Not so much for myself … but for the people who will come after," she said. "For the girls. For the other women."
The San Francisco Archdiocese begs to differ.
Calling the women's ordination movement a "fringe group," spokesman George Wesolek said he was unaware of Eitz's upcoming ordination. The Catholic Church, he said, relies on scripture and tradition and ordains men alone because Jesus was a man and picked men as his apostles.
"The thing you have to recognize here is that the … church is 1.2 billion members," Wesolek said. "The issue of women's ordination and even same-sex marriage are kind of like boutique issues in the church. It's the American church. We're 75 million, but we're really a minority."
But Gary Macy, chairman of Santa Clara University's religious studies department, argued there was "very good evidence of the ordination of women as deacons up until the 12th century.… There are descriptions of women who led the liturgy."


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Im just wondering if anyone has been started on Mirabegron for their bladder and if so how have you gotten on with it. Im due to start soon so any advice really appreciated. Thanks Heather
Multiple Sclerosis Society. Registered charity nos 1139257 / SC041990.
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A teen is being praised for saving her brother from choking.
COLUMBUS, Ga. – Columbus State used a strong second half effort to pull away from visiting North Georgia in a critical Peach Belt Conference match-up as the Cougars won 75-61 AT the Lumpkin Center on Thursday night .
CSU got off to a fast start scoring the game's first eight points including a pair of thunderous jams by BJ Battle and Jermaine Morgan in the opening three minutes of play.North Georgia slowly battled back cutting the deficit to four, 13-9 with 12:35 to go in the half but the Cougars responded pushing the lead to nine over the next four minutes. The 21-12 advantage was the largest for either side in the opening 20 minutes of action. Morgan and Aaron Power both had three points while Nick Turner added a layup during the mini-spurt.Like they did earlier, NGA responded outscoring Columbus State 14-5 over the next four minutes to knot the game at 26-all. The score was tied three more times the remainder of the half before the Cougars went into the break ahead by a point, 33-32.
Just like the start of the game, CSU came out of the break hot scoring 14 of the first 18 points of the second half as they built up an 11 point advantage (47-36) with 14:05 showing on the clock. The trifecta was key to the spurt as three different Cougars drained one from long range including a pair by Battle as he netted eight of the 14 points during the run.
Columbus State maintained at least a nine point edge over the next eight minutes eventually going up 13, 57-44, after Bell nailed a three-pointer in transition.
North Georgia made one final push going on a 9-1 run over the next 2:03 to dwindle the CSU lead down to five, 58-53. Corey Green scored seven of the team's points during that time.
Rory Miller drilled a three-pointer to put Columbus State up by eight with just over two minutes to go and after an empty possession for the Saints, the Cougars sealed the contest going 8-for-10 from the free throw line over the final 1:32.Five different players hit double figures for CSU led by Jermaine Morgan's career high 16 points. Rory Miller (14 points), Idell Bell (12 points), BJ Battle (12 points) and Jahmad Saleem (10 points) were all in double digits. The Cougars didn't help themselves from the line as they were just 19-for-35 overall but were clutch when it mattered. They did help themselves as they won the turnover battle 15-9.Ishmael Hollis registered a double-double as he scored a game high 22 points and also grabbed a game high 14 boards. Corey Green added 14 points while Travis Core chipped in with 10. This is just the second time this season CSU was won a contest in which they were out-rebounded as NGA held a 48-44 edge on the glass.
Columbus State will return to the hardwood on Saturday, when it travels to Milledgeville to take on Georgia College in a PBC showdown. Tip-off is scheduled for 3:30 p.m. ET at the Centennial Center.
1909 Wynnton Road
Columbus, Ga. 31906
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By Jennifer Emert - bio | email ALBANY, GA (WALB) – Meth labs are a growing danger in Georgia, up 75 percent in the last year.
Rolling labs, inside vehicles, are especially dangerous, the equivalent of the vehicle next to containing a bomb. Drug Agents say making this dangerous drug has gotten easier with the development of the Shake and Bake Method, you can do it all in one plastic bottle and learning how to do it is as close as the Internet.
A few clicks on the Internet and you can learn a lot about making Meth.
"The Internet's a good thing, and it helps us, but it hurts us," said Investigator Victor Camp, ADDU agent.
Drug agents say the uptick in Meth Labs from 165 in Georgia last year to more than 289 this year may be the result of new production methods that only need one bottle, instead of the traditional labs to make the product. It doesn't require a heat source, making it more portable and harder to detect.
"You can sit there and make it by yourself and never get caught," said Camp.
In south Georgia, drug agents have recently busted labs in Colquitt, Decatur, Grady, Thomas, and Lowndes Counties.
"In the rural area it's harder to get caught because you can be out in a field somewhere and nobody knows your out there and you can dump all your stuff right there," said Camp.
Agents say the state's effort to restrict the sale of certain ingredients including Pseudoephedrine, marketed in cold medicine, have only lead manufactures to look for a way around the state's law. An East Albany couple forged driver's licenses to buy stockpiles of the drugs to make Meth earlier this year in the shed behind their Duitman Road home.
"If we have any suspicions we can go talk to the pharmacist and maybe with a court order get their log sheet and find out who's getting what," said Camp.
It's a dangerous drug, with explosive consequence which is why drug agents say they're staying on top of new trends to keep neighborhoods safe.
Drug agents say they're need the community's help, if you notice a chemical odor in your neighborhood they ask that you call police and let them check it out.
Nationwide the number of Clandestine labs is up 61 percent.
©2010 WALB News. All rights reserved. Feedback
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Product Pipeline
Molecular Target: CD3-epsilon
CD3-epsilon (or CD3ε) is a molecule that sits on the surface of a white blood cell called a T-cell, or T-lymphocyte. In humans, CD3-epsilon is encoded by the CD3E gene on Chromosome 11.
The CD3ε molecule, along with four other membrane-bound polypeptides (CD3-gamma, -delta, -zeta, and -eta) form the CD3 complex. The CD3 complex, in turn, is associated with the T-cell receptor (TCR), which consists of additional molecules also on the surface of the T-cell, whose job is to recognize and combine with antigens.
When an antigen binds to the T-cell receptor, the CD3 complex sends signals through the cell membrane to the cytoplasm inside the T-cell. This causes activation of the T-cell that rapidly divide to produce new T-cells sensitized to fight the particular antigen to which the TCR were exposed.
While T-cell activation is critical for the human immune system to properly fight bacterial, viral or parasitic infections, abnormal T-cell induction can cause and worsen numerous human diseases, including T-cell lymphoma and leukemia, human malignancies, autoimmune disorders, cardiovascular disease, and transplant rejection.
Novimmune's NI-0401 monoclonal antibody (mAb) is intended to alter auto-aggressive T-cell responses by targeting the T-cell receptor complex.
A Phase I and Phase IIa clinical trial in Crohn's disease, and a Phase I / II open-label study in renal allograft transplantation have been completed.
Product Snapshot
NI-0401 anti-CD3-epsilon
- Modulate T-cell activity with a best in class mAb.
- Phase I / IIa completed two trials in Crohn's disease
(no human anti-human antibodies [HAHA])
- Phase I / Proof-of-Concept completed in renal allograft transplantation
(no HAHA)
- Subcutaneous formulation and drug supply available
- Excellent shelf life, e.g. stable at @5°C, 36 months


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Administrative Coordinator
Administrative Coordinator
The Client is seeking an experienced, full-time Administrative Coordinator. To be considered for this position, a candidate must be a dynamic, positive, self-starter and be able to successfully perform a wide range of administrative tasks to facilitate the efficient operation of the organization.
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By Karen Cohilas - bio | email ALBANY, GA (WALB) - Another prize watermelon in South Georgia. 85-year old Grover Lashley grew a watermelon so large, he needed help to pick it up. On the scales, it comes in at just over 100 pounds.
Lashley said he planted five seeds and one of the plants produced this whopper. The seeds for this variety, the North Carolina Cross, go for about $4.00 for just 10 seeds, since they grow so big.
He said, "It said they would go from a hundred to 200 pounds, so I wanted to see. Yeah, they'll be plenty there to eat, you'll have to have a crowd there to eat that."
Lashley says next year, he hopes to produce an even bigger melon.
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WILMINGTON, N.C. (AP) - Gov. Pat McCrory says education and tougher laws designed to get abusers out of homes are key in battling domestic violence.
The StarNews of Wilmington reports (http://bit.ly/175YkoP ) that McCrory made the comments when he stopped by a domestic violence awareness event in Wilmington on Thursday evening.
Several hundred people gathered for the event in a park and McCrory was leaving a nearby business event when he saw the crowd and stopped by and spoke with participants. October is National Domestic Violence Awareness Month.
McCrory said that education, mental health and drug and alcohol counseling are important in battling domestic violence. He says tougher laws are needed to get abusers out of homes the first time there is a report of domestic violence.
Information from: The StarNews, http://starnewsonline.com
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
3221 South Evans StreetGreenville N.C. 27834
Telephone: 252.355.8500
Fax: 252.355.8568
Email: firstname.lastname@example.com


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Ranging in size from 2012sqm to 2245sqm, fully serviced and nestled in discreet small neighbourhood precinct clusters within the large National Trust Reserve.
Perfectly positioned between Yallingup and Margaret River and only minutes from the stunning Southwest Coastline with its famous surf spots, swimming and fishing locations.
Neighbouring vineyards, country restaurants, art galleries, and tourist attractions.
Adjoining a magnificent forest.
Beautifully landscaped with streams, lagoons and with views over a majestic large lake.
Huge tracts of open space.
Lot 700 - 2245sqm $295,000
Lot 719 - 2045sqm $280,000
Lot 721 - 2018sqm $270,000
Lot 720 - 2012sqm $275,000
Burke CircleCOWARAMUP
Listed Price: from $270,000Sold: 5/8/2013
Jill Turton


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Teams that wanted to play on Doubleday Field are out, at least for April and possibly longer.
Work is under way on fixing the roofing on the stadium, but there will be more work than anticipated after workers removing the shingles revealed that the field-side wood beams underneath also need to be replaced.
The stadium is already closed for rentals in April, and may need an extra few days of work in May, according to Cooperstown Mayor Jeff Katz.
"That's my hope," Katz said. "My gut says we will get it done on time."
The original plan was to replace the shingles on the roof and some of the wood. However, once the shingles came off, it was clear that the wood beams underneath had rotted and more of them needed to be replaced.
The parking lot side of the wood is in good shape and did not need repairs, according to village officials.
Katz said the original bid for the work, which is being done by Mid-State Industries Ltd. of Schenectady, called for replacing 20 percent of the beams, so replacing all the beams on that side should not add much in either cost or time.
"We aren't talking about going from 20 percent to 100 percent," he said. "It is just 100 percent of the one section. That's about a third of the total area. So really we are just talking about another 12 or 13 percent.
"I wouldn't think it would take that much longer," he continued. "We are not talking about another month. The guys are already here up on the roof doing the work. We're just talking about getting the extra wood and taking a little longer."
According to Katz, the money for the repairs will come out of the reserve fund. He added that he did not think the field being closed in April would affect revenues, which are tied to the 2012-13 budget and had been accounted for in last year's projections.


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Here are the facts: approximately 23.7 million Americans have diabetes. New research suggests that the number will double over the next 25 years. Another troubling fact, unfortunately, it is very easy to miss the signs and symptoms that point to diabetes. But, as my own family learned, paying attention to gum disease can help you get a diagnosis and treatment before further complications arise.
Too Close to HomeMy husband was once one of the millions who did not know he had diabetes. As a "tough" guys (sorry, honey), he often avoided seeing his physician even when he was feeling ill. Since he was generally healthy, it didn't seem to matter. Then, almost out of the blue, he began to display some of the obvious symptoms of diabetes. This included blurred vision, frequent urination, unexplained weight loss, increased thirst, and frequent infections. He chalked them up to a recent change in diet. More than six months passed without seeing his doctor, until one day he became very ill and I insisted he see a physician that day. He reluctantly went to the emergency room.
We were soon shocked to learn that his blood glucose level was so high that the nurses couldn't understand why he wasn't in a diabetic coma. In retrospect, we might have known there was a problem if we had just looked at the evidence in his mouth.
A Diabetic Mouth?The American Academy of Periodontology states that periodontal disease - also known as gum disease - could be considered the "sixth complication of diabetes." For my husband, this was perhaps one of the more obvious, yet unexplained signs that something unusual was going on with his health. He brushes and flosses religiously and visits his dentist on a regular basis, but despite his efforts, he encountered a period where it was almost as if his mouth was falling apart. His gums, which are normally very healthy, bled while he was brushing his teeth. He discussed this with his dentist, and was told that he had gingivitis. Efforts to improve his brushing and flossing habits failed to ward off the gingivitis, however more advanced periodontal disease, such as periodontitis, was not yet evident.
How Gum Disease Affects Your Oral HealthWhen bacteria accumulates in dental plaque that has not been effectively removed the teeth and gums, it irritates the gums and causes an infection. Gingivitis is the mildest form of gum disease and often results in little or no discomfort, so it can be overlooked and the problem can worsen. In more advanced stages of gum disease, tooth loss is almost always immanent. Someone with diabetes is more prone to infection. In fact, the World Health Organization classified diabetes as a secondary immunodeficiency diseases.
Like diabetes, millions of people are unaware of the fact that they have some form of gum disease. For a diabetic, gingivitis - the only form of gum disease that is reversible - could rapidly progress to the most serious form of gum disease, known as advanced periodontitis, before they know it. According to a study conducted by researchers from New York University, more than 90% of people with gum disease may be at risk for developing diabetes.
How Gum Disease Affects Your DiabetesAs I mentioned, diabetics are more prone to infections. With severe periodontal disease, a diabetic may develop an infection that raises his blood glucose level, and he may make have difficulty regaining control his glucose levels. Being in control of blood glucose is a diabetics first priority.
Taking ControlLike a viscous circle, gum disease and diabetes - if left untreated or uncontrolled - directly affect one another, in a way that only increases the chances for serious complications from both diseases. Taking control of your diabetes, gum disease, or both will help to cut the risk of these serious complications from occurring.
A study from 1997 involving people with both gum disease and periodontal disease found their diabetes was more in control when their periodontal disease was treated.
The Window to Your HealthIn the case of my husband, the connection between diabetes and gum disease was right in front of us, but we missed it. In the near future, blood glucose testing could become part of your regular dental examination. In the meantime, be aware of the connection between oral health and your overall health and, if you have questions or concerns about diabetes and gum disease, speak to your dentist and your physician.
"Diabetes and Infection". Dr. Bharat B. Trivedi. http://www.perio.org/consumer/mbc.diabetes.htm Accessed: January 15,2010
"Gum Disease and Diabetes. The American Association of Periodontology. http://www.perio.org/consumer/mbc.diabetes.htm Accessed: January 215, 2010
"Projecting the Future Diabetes Population Size and Related Costs for the US." Elbert S. Huang, Anirban Basu, Michael O'Grady, and James C. Capretta. Diabetes Care December 2009, vol. 32 no. 12. http://care.diabetesjournals.org/content/32/12/2225.full Accessed: January 15,2010
Study Finds Over 90% of People with Gum Disease Are at Risk for Diabetes; Concludes That at Least Half Could Be Screened in Dental Offices." December 14, 2009. http://www.nyu.edu/public.affairs/releases/detail/2919 Accessed: January 15, 2010


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Simon Zebo on longlist for European player of the year
Published 22/01/2013 | 17:48
MUNSTER winger Simon Zebo is included on the longlist for the 2013 ERC Player of the Year.
The Corkman scored a hat-trick against Racing Metro ast weekend, and has been named on the 15-man list along with Rory Best and Ruan Pienaar of Ulster.
Voting was based on player performances during the pool stages of the Heineken Cup and the Amlin Challenge Cup.
A number of players including Wesley Fofana of ASM Clermont Auvergne, Owen Farrell of Saracens and Pienaar are included agains having made made last year's longlist.
The overall winner will be named after the ERC European club finals in Dublin this May.
Leinster's Rob Kearney won the award last year.
*ERC Player of the Year longlist
Steffon Armitage ( Toulon), Rory Best ( Ulster Rugby), Julien Bonnaire (ASM Clermont Auvergne), Mike Brown ( Harlequins), Dan Cole ( Leicester Tigers), Owen Farrell (Saracens), Wesley Fofana (ASM Clermont Auvergne), Mamuka Gorgodze ( Montpellier), Charlie Hodgson ((Saracens), James Johnston (Harlequins), Joe Launchbury ( London Wasps), Morgan Parra (ASM Clermont Auvergne), Geoff Parling (Leicester Tigers), Ruan Pienaar (Ulster Rugby), Simon Zebo (Munster).


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|This is a previous ECG from months ago, showing that the presentation ECG is indeed New LBBB. Here there is profound LVH with secondary ST/T abnormalities.
This did not alarm me. In ED patients with symptoms of ischemia and New LBBB, only about 2-4% have acute coronary occlusion (need for immediate reperfusion therapy). Many more have MI as diagnosed by biomarkers. This is typical evolution of severe LVH to LBBB in a patient with severe HTN. There may well be MI as diagnosed by biomarkers, but it is not due to acute coronary occlusion, rather most likely to demand ischemia from severe hypertension (afterload, "type II" MI).
Troponin I had a rise and fall, but never went above the 99% reference value for the VITROS assay (in ng/ml): 0.017, 0.018, 0.029, 0.020. So this also represents a case that had some tiny amount of myocardial necrosis but is by current definition not an MI.


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'In Living Color' reboot coming to FOX midseason 2012
Do you remember the sketch comedy series In Living Color that aired on FOX from 1990 to 1994? It was created by the second eldest Wayans brother Keenan Ivory Wayans and it featured a cast that was predominantly black including big stars like Wayans' family members Damon, Shawn, and Marlon, Jamie Foxx, David Alan Grier, Jim Carrey and Jennifer Lopez was introduced to the world as one of the Fly Girls. Well news broke that the show is coming back to FOX as the network is celebrating its 25th anniversary later this year. Keenan Ivory Wayans is back as executive producer and this time he will play host, too. FOX has ordered two half-hour primetime specials that will air in midseason, and they picked up a series option. This means that if the sketch show performs well in the ratings, FOX can pick it up to series and allow Wayans to pump out additional episodes. (Re)introduce yourself to one of my favorite characters from In Living Color after the break, Homey D. Clown.


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SANTA CLARA, Calif. -- San Francisco 49ers quarterback Alex Smith practiced again on Saturday, however his availability is still uncertain for the game against the Chicago Bears.
Smith suffered a concussion last week against the St. Louis Rams.
He still hasn't been cleared to play by doctors, and the 49ers (6-2-1) might not get a final verdict on his status until hours before Monday's NFC showdown against the Chicago Bears (7-2).
"Alex is still going through the protocol right now," offensive co-ordinator Greg Roman said Saturday. "And that's in the doctor's hands. When we know, you will probably know."
Smith did not speak to reporters Saturday.
For the fourth consecutive day, Smith practiced in a non-contact black jersey and took part in most of the drills involving the first-team offence. The NFL's third-ranked quarterback with a passer rating of 104.1, Smith has received positive reviews throughout the week.
"He's looked good, really sharp," Roman said. "He's gotten plenty of practice time. There's a lot of different scenarios this week and it's fluid. We talk through them, and it will change according to how the big picture changes, and obviously the quarterback position is a huge piece of that."
Smith, who has made 28 consecutive starts, was injured during the first half of a 24-24 tie with the Rams and left the game midway through the second quarter. He was replaced by second-year veteran Colin Kaepernick, who would make his first career start Monday if Smith is unable to play.
Offensive tackle Joe Staley suffered a concussion in Week 6 against the New York Giants, and he went through the NFL-mandated protocol before returning to play the next week against Seattle. Staley said he has seen nothing from Smith in practice this week to suggest the quarterback won't be able to return against the Bears.
"He was normal as far as going through all his tests," Staley said. "He just has to go through the final steps."
The Houston Texans selected defensive end Jadeveon Clowney first overall in the 2014 NFL Draft.
Round-by-Round Picks: 1 | 2 | 3 | 4 | 5 | 6 | 7
Ray Guy, Derrick Brooks, Walter Jones, Michael Strahan, Andre Reed, and Aeneas Williams, headlined this year's Hall of Fame class. More...
Pro Football Hall of Fame VP of Communications Joe Horrigan joined Game Night with Jim Tatti & Andy McNamara to talk NFL Hall of Fame Weekend
SunMedia NFL Columnist, John Kryk joined Bryan Hayes to discuss the potential of Manziel & EJ Manuel's struggles in camp.
ESPN NFL Analyst, Jim Trotter joined Bryan Hayes to discuss Tony Dungy's comments about Michael Sam, Brett Favre's Packers legacy & Johnny Manziel.


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I just realized that I live on the same planet as J.K. Rowling.
I just realized that I live on the same planet as J.K. Rowling.
this probably is the best day of my life since 13 juli 2011!
the golden trio: Ron & Hermione & Harry
(Source: sextective)
"just because you've got the emotional range of a teaspoon doesn't mean we all have"
A kiss that is never tasted, is forever and ever wasted.
pretty much describes whole my love life…
"What Harry found most unusual about life at Ron's, however, wasn't the talking mirror or the clanking ghoul. It was the fact that everybody there seemed to like him. Mrs. Weasley fussed over the state of his socks and tried to force him to eat fourth helpings at every meal. Mr. Weasley liked Harry to sit next to him at the dinner table so that he could bombard him with questions about life with Muggles, asking him to explain how things like plugs and the postal service worked."
the fandom who lived ϟ


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Breaking news: gallo just communicated he has no torn ACL. Return will be much earlier than expected.
Go to https://www.facebook.com/danilogallinari.
Unfortunately for the time being it is just in Italian... He says he had an innovative treatment after first surgery.
I am not an expert so I am not sure what this exactly means, but it looks like an incredibly good news
I hope this means he will be ready for the training camp. I am crossing my fingers.


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This Brive style braised rabbit recipe hails from Brive-la-Gaillarde, a commune in south-central France. The stew is filled with the tomatoes and ceps, or porcini mushrooms, grown in the area. Paired with roasted potatoes, a green salad, and white wine, this comforting dish is ideal for an easy, well-rounded dinner.
Prep Time: 10 minutes
Cook Time: 55 minutes
Total Time: 1 hour, 5 minutes
- 1 tablespoon duck fat
- 8 shallots, finely chopped
- 2 cloves garlic, crushed
- Leg and saddle of 1 large rabbit (not separated)
- 3/4 teaspoon salt
- 1/4 teaspooon ground black pepper
- 1/4 cup dry white wine
- 4 plum tomatoes (blanched, skinned, and halved lengthwise)
- 1/4 teaspoon dried thyme
- 10 ounces ceps, cleaned (porcini mushrooms)
In a large skillet over medium heat, sauté the shallots and garlic until they turn tender and start to caramelize, about 5 to 7 minutes. Transfer the shallots and garlic to a bowl and set aside.
Season the rabbit with the salt and pepper; add it to the pan and cook over medium-high heat for 4 to 5 minutes on each side, to brown it thoroughly. Deglaze the pan with the white wine and tomatoes. (Stand back a bit; the process will send up a short burst of steam.)
Return the caramelized shallots and garlic to the pan, along with the thyme and ceps. Reduce the heat to low, cover the pan, and allow the rabbit to simmer for 40 minutes, until it is cooked through.
This Brive style rabbit stew recipe makes 4 servings.


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This is the deluxe limited edition of Taylor Swift's self-titled debut album. Added to the original version are three additional songs, plus listen to Taylor's first phone call with Tim McGraw. This collection also adds a DVD with each of Taylor's videos, plus special performances, like her first Opry performance, and specials from both GAC and CMT. Lastly, you can view Taylor's home movie, which she edited herself. Even if you have the original version, the additional goodies are well worth buying this version of the album as well.
A Little Background on Taylor Swift
They say to write about what you know, and that is exactly why Taylor's songs work. She writes about her personal experiences in a way that so many people can relate. Whether they are living through their teenage years, or looking back on what it was like when they were that age, it's relatable.
At the writing of this review, Taylor has released three singles, "Tim McGraw," (No. 6) "Teardrops on My Guitar," (No. 2) and "Our Song" (Currently No. 9).
The New Music
The next new song is "Invisible." This song is about a girl that likes a guy who is dreaming about someone else, even though the other girl doesn't know he exist. Taylor sings, "But if you only knew me, we could be a beautiful miracle, unbelievable, instead of just invisible."
The final song is "A Perfectly Good Heart." This is probably something everyone can relate to that has been dumped. She asks him "Why would you wanna break a perfectly good heart? Why would you wanna make the very first scar?"
The final track is her first phone call with Tim McGraw. This starts with Lon Helton of CMT Country Countdown USA talking about the first time he heard Taylor's song, "Tim McGraw," and then they get Taylor on the phone and it's just really cute. This is also where she asks him about adding opening acts to his tour, and suggests herself as an opening act.
The DVD
Besides the videos for "Tim McGraw" "Teardrops on My Guitar," and "Our Song," there is also Behind the Scenes at the "Teardrops on My Guitar" and "Our Song" video shoots.
For fans that may not have access to GAC, you can watch the special they aired on Taylor, called A Place in This World. Then, watch Taylor's performance of "Picture to Burn" from her CMT 330 Sessions show.
The last track is a lot of fun. It's Taylor's Home Movie, and she edited it herself. It features her family and band members as they traveled on vacation. Fans will love the personal looks of Taylor snacking on whipped cream from the can, and visiting the beach, riding a jet ski, and much more. Really cute stuff here.
Even though much of the music is the same as on the original release, I think this version is worth the money just for the extra tracks, and the phone call with Tim McGraw, and of course, all the video footage in one place. Not everyone has access to both CMT and GAC. Some fans don't have access to either one, and I think they'd really enjoy watching these two features, as well as Taylor's videos for her singles. Two thumbs up from me.
Track List:
- Tim McGraw
- Picture To Burn
- Teardrops On My Guitar (radio single version)
- A Place In This World
- Cold As You
- The Outside
- Tied Together With A Smile
- Stay Beautiful
- Should've Said No
- Mary's Song (Oh My My My)
- Our Song (radio single version)
- I'm Only Me When I'm With You *
- Invisible *
- A Perfectly Good Heart *
- Taylor's 1st Phone Call w/Tim McGraw *
* New tracks.
DVD Track List:
- "Tim McGraw" video
- First Grand Ole Opry Performance of Tim McGraw
- Yahoo! Music Performance & Interview feature of "Tim McGraw"
- "Teardrops On My Guitar" video
- "Teardrops" Behind The Scenes
- "Our Song" video
- "Our Song" Behind the Scenes
- GAC Short Cuts Series "A Place In This World"
- CMT's Unplugged video Performance of "Picture To Burn"
- Taylor's Home Movie Clip


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A 59-year-old woman died Wednesday night following a single-vehicle crash in DeRidder, authorities said.
DeRidder Deputy Chief Christopher Rudy said the accident occurred around 6:50 p.m. near the intersection of Blankenship Drive and Dees Street.
"The driver left the roadway, over corrected and lost control," Rudy said Thursday in a news release. "The vehicle struck a tree. The driver, who was lone in the vehicle, was not wearing a seat belt and had to be extracted."
The identity of the driver is not being released pending notification of next of kin.
Copyright 2014 KPLC. All rights reserved.
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The Emme Lodge is one of these farmhouses built in 1768 just on the outskirts of the village. The Hostel is only... More Info »
Video guides, travel podcasts, city maps & free city guides. What to eat, where to stay and things to do and see - our travel guides have it all.Find a guide »
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We offer the most comprehensive selection of hostels on the internet with over 35,000 great places to stay in 180 countries. The ultimate online resource for hostels everywhere.Find great value hostels »


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I know some of you like talking re the draft and potential trades, and some of you despise it !
Boomer Esiason has come out stating that he is pretty certain the Bengals will pick Blaine Gabbert at #4 which I thought had some interesting ramifications for the Bills draft day plans.
Assuming that the Cardinals or another team has strong interest in Blaine Gabbert as it's QB of the future (and assuming he doesn't go to Carolina or Buffalo) then it would seem that the Bills are in a great position to entertain possible offers for our #3 spot.
Obviously it all depends on the offers, how far Nix would entertain moving down (which will again depend on the offer) etc, however it just adds a little more potential value to our #3 spot if indeed Boomer is on the mark.
What do you all think ? do you think there's much potential merrit to this and if so do you think it increases (even if slightly) the chances of seeing the Bills trade down for an extra pick or 2 ?


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Thread: Template hierarchy question
Aug 26, 2010, 05:54 #1
- Join Date
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Template hierarchy question
Scenario 1
My website's home page url is http://www.example.com
I want my latest posts to display at http://www.example.com/news
My understanding to accomplish this..
I will have to go to the Reading Settings page in the Wordpress Dashboard and then ensure that the "A static page" is selected in the option for the Front page display.
Then i would have to select what page is used for the front page display and also the posts page.
My first question:
What template will wordpress look for to display the static home page?
Is it front-page.php or home.php or index.php?
Aug 26, 2010, 06:02 #2
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Scenario 2
My website's home page url is http://www.example.com
I want to display the home page according to front-page.php (It displays all my posts)
Lets say i've created every possible template do display every page type:
category.php - Used to display all the posts for my categories
search.php - Used to display the search results
404.php - Used to display a page not found
tag.php - Used to posts queried via tags
single.php - Used to display my blog posts
page.php - Used display my pages (about, contact)
sidebar.php - Used to contain sidebar contents and a widgetized area
header.php - Used to contain all the header contents
footer.php - Used to hold all the footer content
not forgetting the template to display taxonomies and attachments and authors..
Will i still have to create index.php? Will it be redundant as i've got front-page.php to display all my posts and to show it on the home page http://www.example.com
Aug 26, 2010, 17:59 #3
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Scenario 1:
To have your blog page be example.com/news, create a Page in the Dashboard called "News". Then under reading settings, set the posts page to static and select "News" from the drop-down list.
That leads us into...
Scenario 2
1. Turn "front-page.php" into a page template. (http://www.wordpressmax.com/customiz...ss/custom-page).
2. Create a new Page in the Dashboard and set it to use that template you created in step one.
3. Go to Reading Settings and set that page you created in Step Two as your home page.
Yes, you still need index.php. index.php and style.css are the two files that all WordPress themes must have. And since you're using custom templates, you must have an index.php file.


text: They moved the Blackhawks vs Avalance game over to CSN + today. For those who are in the dark, the Blackhawks have become a phenom and I can't see why CSN would move the most elite hockey team over to the backup channel for a Bulls vs Nuggets game if the return was not happening. Just a hunch ( but I think a good one). I firmly believe if he don't return Monday he's done for season.


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Objective Panel Review
(also known simply as "Panel Review")
About Panel Review
Each year, ANA convenes panels of experts to objectively analyze and score eligible grant applications. These scores are used to rank eligible applications which help ANA decide which eligible tribes or native organizations will receive funds. Being a panel reviewer is an integral part of ANA's funding process and affords participants the opportunity to have a significant impact in native communities.
ANA recruits experienced professionals who possess subject matter expertise and qualifications relevant to ANA's program areas to serve as panel reviewers and panel facilitators. Panel reviewers should have knowledge and direct experience working with the Native communities and populations that ANA serves. Panel reviewers objectively analyze, score, and comment on ANA grant applications. Panel facilitators assist the panel in coming to a consensus on comments and scores that accurately reflect the quality of each application as it is applied to the evaluation criteria prescribed in the Funding Opportunity Announcement (FOA).
For more information regarding the roles and responsibilities of panel reviewers and facilitators, please download the following job descriptions.
What is an Objective Review?
Objective review involves the thorough evaluation of the technical aspects of the grant application through an objective review process. The evaluation is based on an unbiased appraisal of the merit of the application's response to the criteria published in the respective FOA. Objective review is an advisory assessment of applications conducted by a minimum of three unbiased peer reviewers. Objective review is essential to ensuring selection of applications that best meets the needs of the program consistent with established criteria and providing assurance to the public that the evaluation and selection process is impartial and fair.
What is it like to be an ANA Panel Reviewer?
Panel review is hard work and challenging but an incredibly rewarding process. ANA uses the recommendations produced from the panel review process to help determine which grant applications receive funding. Because of this reliance, important decisions rest in the hands of each panel reviewer. As an ANA panel reviewer or facilitator, you may be assigned seven to ten grant applications per review session. In addition to working independently to read, analyze and score each assigned grant application, you will participate in team discussions requiring critical thinking and writing skills while working with a panel consisting of three reviewers and a facilitator.
What are the qualifications ANA looks for in a reviewer or facilitator?
- Experience in community-based projects
- Good communication skills, verbal and in writing
- Attention to detail
- Analytical skills
- Experience working with native communities or other distressed communities
- Ability to meet deadlines
- Independant thinker that can also work collaboratively with others
Where is the ANA Panel Review held?
Panel Review is held off site. Facilitators and reviewers are required to have constant reliable Internet access, a contact phone number which allows ample opportunity and time to participate in lengthy conference calls, and be flexible with their time during each session.
Are Panel Facilitators and Reviewers compensated for their time?
Facilitators and reviewers are compensated for each application which is read, commented, scored, and a report completed. They also receive a flat printing and supply stipend. Compensation is provided at the end of the Panel Review session.
When will the FOAs be published?
The Funding Opportunity Announcements were published on February 14, 2014. Applications for FY2014 are due April 15, 2014. Click here to view the funding announcements on our website. The FOAs open for competition are in the following areas:
- Native American Language Preservation and Maintenance
- Native American Language Preservation and Maintenance - Esther Martinez Immersion
- Social and Economic Development Strategies (SEDS)
- Sustainable Employment and Economic Development Strategies (SEEDS)
- Environmental Regulatory Enhancement
How do I apply to be a Panel Reviewer?
Download and complete the Panel Review Questionnaire which should be returned to email@example.com along with a copy of your current resume (click here to download the latest version of Adobe Reader). You will be notified when ANA receives the form and if any additional information is required. If selected for the potential pool of panel participants, you will be required to participate in training in order to be assigned to a panel review session.
What if I Have Questions or Need Help with the Application Process?
Call the ANA Help Desk at 1-877-922-9262
8:30 am to 6:00 pm EST (M-F)


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Moon Over Bourbon Street
Season 1, Ep. 17
Original Air Date: Mar 18, 2014
After accusing Klaus of doing nothing while their control over the Quarter crumbles, Elijah makes a move to take matters into his own hands.
The Originals
Moon Over Bourbon Street (Ep.117)
Original Air Date: 3.18.14
Rescue Me
Season 5, Ep. 17
Original Air Date: Mar 27, 2014
In order to keep Stefan from being harmed by Sloan and the Travelers, Caroline and Enzo agree to make a trip to Atlanta to find a newly discovered doppleganger.
The Vampire Diaries
Rescue Me (Ep.517)
Original Air Date: 3.27.14
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So for a couple years now we've been ooo-ing and ahhh-ing at our talent at running back. And I, for one, thing the hype is for real. But what about Jason Garrett? Why is it that we have a first & goal at the 6 yard line, with a back-up quarterback, and we throw 4 passes? Why is it that we couldn't throw TC out there? Are you telling me that Tashard wasn't hyped up enough to get 6 yards on 4 tries?
I understand our o-line is aging and isn't what it used to be, but we have some backs that can make things happen. But Garret would rather trust a back up that has no significant playing time in a year to throw the ball. And what happened? Three of the four passes sail out of the back of the end zone.
I'm so sick of RedBall thinking he can out smart everyone. If we've learned anything this far through the season it's that the cowboys do have some talent, but they are not breaking any IQ records here. Let's get back to basics. You get four downs from the 6 yard line, with those three backs to choose from, you run the ball.
In a game like that there are a lot of things to hate....but that one really stuck out at me.


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For the 1st time in 4 years, Wando had advanced to the AAAA Lower State Volleyball finals with a 3-0 sweep of Lexington on Tuesday night. The Warriors will take on Aiken on Thursday night for a spot in the State Finals on Saturday.
Wando improved to 46-7 on the year.
Britney Vallez led the Warriors with 13 kills while Natalie Tucker had 37 assists.
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text: LUXEMBOURG – OCTOBER 20: Princess Stephanie of Luxembourg blows a kiss to the crowds from the balcony of the Grand-Ducal Palace following the wedding ceremony of Prince Guillaume Of Luxembourg and Princess Stephanie of Luxembourg at the Cathedral of our Lady of Luxembourg on October 20, 2012 in Luxembourg, Luxembourg. The 30-year-old hereditary Grand Duke of Luxembourg is the last hereditary Prince in Europe to get married, marrying his 28-year old Belgian Countess bride in a lavish 2-day ceremony. (Photo by Andreas Rentz/Getty Images)


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Drum Machines
View Single Post
2004-12-16, 01:55
NZ black metal drumm
Join Date: Jul 2004
Location: In the Uber Kvlt shithole (NZ)
Posts: 1,102
that is a funny little problem you have there!!!
but what I would suggest is actually sitting your drummer down and teaching him musical theory,
of course you could not do any of that and let him come up with some truely creative shit but as for getting a drum machine to do that, I wouldn't, just use a drum loop program like fruity loops or something like that.
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HAMMOND � Southeastern Louisiana University's dance program is holding auditions Sunday, July 22, for an upcoming tap dance concert. Sponsored by the Department of Fine and Performing Arts, the concert will be held on Nov. 8 in Pottle Music Auditorium.
Auditions are scheduled from 3 to 4 p.m. in the dance studio located in the Kinesiology and Health Studies Building. Dance Professor Martie Fellom said the auditions are open to Southeastern students, who can earn a one-hour credit for rehearsals and performance.
"Students should arrive at 2:45 p.m. to fill out an audition form prior to the audition," Fellom said. "They should wear comfortable clothing and, of course, tap shoes. The audition will conclude by 4 p.m."
For more information contact Fellom at email@example.com or (985) 549-2133.


text:
Export Controls Relating to
Commercial Communications Satellites
Prepared Testimony of
John Pike
Space Policy Project
Federation of American Scientists
before the
House Rules Committee
16 June 1998
The impact on US national security of commercial space activities with the People's Republic of China, and the adequacy of existing export control mechanisms to police the proliferation of this technology, has been a long-standing concern of the US Government.The approach of selective engagement followed by the Clinton Administration lacks the simplicity of our consistently adversarial policies of decades past, as it requires the difficult balancing of diverse interests. But given the choice between the challenges of seeking the proper balance, and the far greater risks of returning to outright confrontation, there should be little doubt as to where American national interests lie. Over time our current engagement initiatives may fail, and despite our best efforts we may in the 21st Century confront security challenges from China that may rival those posed by the Soviet Union. But it is far to soon to conclude that this moment is at hand, and surely premature to abandon efforts to avert this outcome.
Werner von Braun "aimed for the Moon and hit London." Since the dawn of the space age and the missile era, the primary distinction between space launch vehicles and missiles has been attitude, and only secondarily altitude. The first American and Soviet satellites were launched on converted military missiles, and derivatives of missiles have remained the mainstay of our respective space programs. Over time, new space launch vehicles have been developed whose missile pedigree is far more attenuated, and whose applicability as engines of war is rather difficult to envision.
But it remains trivially true that many of the major technical arts applicable to the challenges of missilery are equally applicable to space launch operations. The more challenging question is to unravel the actual military significance of specific technologies.
As with so many other technologies, China was the birthplace of rocketry. With initial assistance from the Soviet Union, China has in recent decades developed a diverse inventory of military missiles and derivative space launch vehicles.
China has between 10 and 20 CSS-3 / DF-4 (Dong Feng or East Wind) IRBMs with a range of 4,750 km. (3,000 miles). While these are capable of placing targets in Russia at risk, the continental United States is beyond their reach, at a distance of over 6,000 miles from China [even Honolulu is nearly 5,000 miles away].
The DF-5A [CSS-4] is a liquid-fueled silo-based ICBM with a range of 13,000 km. (8,125 miles) carrying a single 5 MT nuclear warhead. The missile has also reportedly been tested with multiple warheads [MIRV]. With an initial operational capability in 1981, for many years thereafter the DF-5A was deployed in small numbers, with open source estimates ranging from four to ten operational missiles. Other sources have more recently estimated that currently this number may be as high as 20 missiles. The Long March CZ-2 space launch vehicle derivative of this missile has, with various modifications, been used by China to launch both its own satellites and those of other countries.
The DF-31 is a three-stage solid-fuel missile with a estimated range of 8000 km carrying a single one-megaton warhead. This missile, which may become operational by the end of this century, could be used to strike targets in the northwest corner of the United States from launch sites in Manchuria.
The DF-41 three-stage solid-fuel missile, which will have a range of some 12,000 km, is projected to replace existing CSS-4/DF-5 ICBMs by the year 2010.
Concerns have been raised as to whether interactions with American commercial satellite operators have led to the transfer of technical information that would be useful to the Chinese in improving the reliability or capability of these missiles. Given the ongoing investigations of these matters, and the consequent limited public availability of detailed technical information, it is difficult to form a definitive view on this matter. But several general observations are certainly possible, and necessary, at this juncture.
The nature and volume of the technical data alleged to have been transferred by American companies is surely trivial compared to the extensive Soviet aid that facilitated initial Chinese efforts in this field. But even with that assistance, China faced a steep road into space, and has developed a robust domestic design and manufacturing capability. While technical insights from colleagues in other design communities are always of interest, there is no "secret ingredient" to American rocketry that could produce startling breakthroughs for the Chinese.
I would stipulate that recent exchanges between American and Chinese companies may have resulted in the transfer of technical information of some military significance. Certainly, I am not prepared to dispute published reports that the Defense Department has raised concerns that such transfers have or could have resulted in a harm to US national security interests. Indeed, if one contemplates the mountains of trivial information that the Defense Department classifies as SECRET, it is difficult to imagine how it could be otherwise. It was not until a few years ago that the government finally got around to declassifying military plans dating back to World War I, so I can easily imagine how the Defense Department would be inclined to err on the side of caution in the present matter.
At present, however, there is no indication in the public record of an actual identifiable harm to American security interests. Irresponsible public claims to the contrary, China today has no capabilities to attack to the United States that it did not have a year ago, or a decade ago.
Concerns have been raised about the potential for American technical information to be used by the Chinese to improve the accuracy or reliability of their ICBM force. There is no indication that this has in fact happened, there is little reason to anticipate that it will happen, and even less reason for American concern should it happen.
For nearly three decades the Chinese have maintained a small arsenal of ICBMs capable of targeting American cities. It is the fact of the existence of this force, rather than the fine-grained details of its technical characteristics, that has defined their "existential deterrence" posture, their ability to "tear off an arm and a leg."
The space launch industry is extremely sensitive to questions of launcher reliability, with launchers exhibiting reliability lower than the prevailing 90%-95% rates facing potentially prohibitive insurance premiums. Unlike space launch vehicles, the difference between 75% reliability and 90% reliability of the Chinese missile force would have no material bearing on the quality of the existential deterrent, in either Chinese or American calculations. High confidence in high reliability of missiles has been an abiding concern of the United States, but we face very different operational requirements of achieving prompt hard-target kills against Russian ICBM silos. I am concerned that, in the absence of rapid and significant reductions in American and Russian nuclear arsenals, China may over the coming decades built up to current American force levels, and develop an appetite for high confidence in high reliability. Hopefully we can forestall this development, but should we fail, we will not confront a Chinese arsenal of liquid-fueled DF-5s, but rather a more numerous arsenal of new solid-fueled DF-31s and DF-41s. Any insights into the reliability of the DF-5A gained in the 1990s would surely be of vanishingly little relevance to the reliability of the utterly unrelated DF-31 deployed in the year 2015.
While accuracy is also of interest in both the missile and launch fields, divergent considerations apply. Satellite operators generally set standards for launch vehicles placing their satellites into some proximity of the ultimate destination orbit. But the margin for error in the real world is normally many miles, and since satellites always carry maneuvering propellant, it is left to the satellite rather than the launcher to reach the ultimate destination. The warheads carried on missiles have no such supplementary guidance or propulsion capability, and rely entirely on the missile [and the quality of the reentry vehicle] to reach their terrestrial destination. The accuracy of existing Chinese missiles is not well characterized in the open literature, but is surely denominated in miles rather than the hundreds of yards characteristic of their American counterparts. Such accuracy is consistent with the city-busting role of the existing Chinese missile force. Close does count in horse-shoes, hand-grenades, and global thermonuclear war. It matter little to the China [or America] precisely which part of Los Angeles is the actual ground zero. It should be recalled that the atomic bomb dropped on Nagasaki actually missed by a wide margin, a fact lost on the citizens of that unfortunate city. Again, over time this may change, and we may a few decades hence confront a Chinese nuclear arsenal that is both as numerous and as accurate as that deployed by the United States today. While this would represent a profound policy failure on the part of the United States, to the extent that it is within our control, the potential transfer of technical data related to current Chinese launch vehicles would not materially contribute to this failure.
A variety of other concerns have also been raised about the national security implications of US commercial space cooperation with China, though these seem to be even less substantial.
Over time the multiplication of such ill-founded allegations concerning the national security risks of commercial space activities with China has increasingly exposed the relatively insubstantial nature of the entire episode. While there are serious and unresolved concerns about Chinese activities, these are not properly numbered among them.
- The launch of several Motorola Iridium communications satellites on a Chinese launch vehicle did not contribute to Chinese capabilities to launch multiple warheads on its missiles, but rather reflected existing Chinese capabilities, both for launching multiple satellites and multiple warheads. In any event, the technical requirements for deploying satellites and warheads are sufficiently different that proficiency in satellite deployment says little about proficiency in the accurate deployment of warheads [and such deployment accuracy is only one of many factors in overall warhead accuracy].
- American software used to analyze structural loads and deformations on launch vehicles might improve the comfort of the ride of relatively fragile commercial satellites. But nuclear warheads must survive not only launch but reentry, and the reentry environment is far more stressful than the launch environment. Any reentry vehicle that can survive reentry would be entirely indifferent to a slightly smoother ride on the way up.
- While Americans have engaged in discussions with their Chinese counterparts to evaluate the potential for integrating American built "kick-motors" onto Chinese launch vehicles, there is no indication whatsoever that these discussions included transfers of technology, and little reason to believe that there would be a significant potential for military applications for such systems. As the name implies, a "kick-motor, " which is really just an additional upper stage for the launch vehicle, provides the final kick needed to place a satellite into orbit. The rough kick provided by such motors is a far cry from the precise maneuvers needed for the multiple-warhead post-boost vehicle.
Given the ongoing investigation of allegations of unauthorized transfers of technical information China, it is impossible at this point and in this forum to provide a definitive answer as to the adequacy of current export control regulations and their implementation.
The Bush Administration inaugurated the policy of allowing American content commercial satellites to be launched on Chinese launch vehicles, with the understanding that in the process there must be no contribution to China's capability to design, develop, operate, maintain, modify or repair a launch vehicle. Over time licenses issued under this policy have been modified to eliminate any uncertainty on this point. If in fact these policies have been violated or circumvented, appropriate penalties should be imposed, and consideration given to further measures to reduce the risk of future infractions.
However, as we have seen in other situations ranging from export control administration to domestic law enforcement, no regulatory regime can assuredly preclude inadvertent or unscrupulous infraction. The question is not whether we should or can modify the existing regulatory environment to confidently preclude the possibility of the transfer of any and all technical information with potential military applications to China. Rather the much more challenging question is whether the existing regime strikes the proper balance between overall American national and security interests, and the risks that are inherent in transactions with a state such as China, with which we have both common and divergent interests.
The judgement of the present and previous Administrations is that the current approach strikes this proper balance. If anything, general trends in the nature of the relationship between technology and national security increasingly appear to reinforce this judgement, recent doubts notwithstanding.
Technological innovation and superiority have been at the core of the American way of war since the birth of the American Republic. The production of mass-produced muskets with inter-changeable parts is part of the folklore of the early years of the American army, and the War Between the States was marked by introduction of a variety of new engines of war that came to dominate subsequently conflicts. Throughout the 20th Century American operational culture consistently sought to substitute treasure for blood, seeking means of replacing, or at least augmenting, men with machines on the battlefield. The contest for technological superiority was at the heart of the Cold War arms race, and unchallenged American technological supremacy is the hallmark of the sole remaining superpower.
But the traditional Cold War models and institutions have proven poorly suited to the new security environment and the emerging information economy.
The Defense Department is no longer the central engine of technological innovation. In the Colonial era the War Department was responsible for a wide variety of scientific and technological innovations that subsequently found commercial application. And in the early years of the Cold War the Department of Defense sponsored the development of many of the technologies that form the basis of today's economy, ranging from the jet engine to radar and space systems. By the late 1970s and early 1980s it had become increasingly clear that highly specialized military technologies such as thermonuclear weapons and stealth had little relevance for the commercial sector. And by the early 1990s it was increasingly apparent that the defense sector's relationship to the commercial sector was more appropriately cast in the role of pupil rather than tutor.
The transformation of the relationship between military and commercial technological innovation has been accelerated by the changing face of warfare. For many the 1991 Gulf War was the watershed event in which silicon trumped steel, in which the dominant battlespace awareness afforded by sophisticated information systems over-awed a less sophisticated military preoccupied with the weapons of a bygone era. Even less exuberant observers of the contemporary scene acknowledge the increasingly decisive role played by information systems in the modern military. And the fundamental lessons of the new information economy have not been entirely lost on the Defense acquisition establishment: open systems leverage the power of the marketplace to provide the most powerful capabilities at the lowest cost.
During the Cold War the race for technological superiority was waged by contending military research and development establishments that sought to be the first to develop and field uniquely military weapons systems. In the new information era technological supremacy lies in the art of rapidly mastering and incorporating commercially developed information systems and learning to apply them to military problems. This model requires a radically different mindset and culture than has prevailed in the past and remains too prevalent today.
During the Cold War the Soviet Union sought to impose absolute control over information relating to not only militarily unique technologies, but also information pertaining to virtually every other aspect of their economy. The judgement of history is surely that this simple-minded model was perhaps less successful than its authors might have hoped.
Throughout the Cold War the United States was prepared to take greater risks with technical information. While not blind to the dangers of the promiscuous dissemination of hard-won technical insights, these Cold War policies were also very much alive to the essential contribution of the flow of technical data in building a vibrant economy.
With the fundamental shifts currently underway in both the emerging global information economy, and the ongoing revolution in military affairs, once again prudential risk taking is essential if we are to avoid the pitfalls of the Soviet model, which in seeking to control everything was in the end unable to control anything.
We live in a real world in which the art of decision making lies not in choosing obvious and easy courses which are certainly beneficial and without costs, but rather in the more challenging act of choosing among alternatives which have risks and uncertainties, and costs as well as benefits. On balance the course taken in this decade with respect to the Chinese launch vehicle has had diverse benefits, and manageable risks. This set of policies has strengthened the American satellite industry, enhancing our global dominance of this strategic sector and in the process increasing the diversity and capability of communications available to our military forces world wide. It has engaged the energies of the Chinese aerospace industry, and perhaps moved them towards seeing space development rather than missiles as the central focus of their growing role in the world. It has given us leverage in discouraging their transfer of special weapons technologies to other countries, notably Pakistan. While these efforts have clearly not been as successful as we would have wished, our non-proliferation sticks would have been even less effective in the absence of the carrots of space cooperation.
We should not allow current controversies to obscure the fundamental soundness of this approach, but even more critically, we should not allow this current controversy to distract us from the more pressing and significant challenges to US security interests.