text:
Sue Carter's articles written for
Battlefield Australia: Frontier Conflict in Early Australian Settlement; Cartimandua - Licentious Ruler or Political Pawn?; Archaeological Typologies - The Issues; Warfare In Iron Age Britain Part 1; Warfare In Iron Age Britain Part 2; The Icknield Way - Track or Fiction?; Royston Cave - A Knights Templar Mystery of History?; Periwinkle Hill - A "Proposed Motte and Bailey Castle"; Whose Your Daddy?; Let Us Do Our Job!; The Original Boat People; Did Famine Destroy "Camelot"?
* Moated fortified house built on the site of a previous castle and constructed of dark red stone and flanked at each angle by a low square machiolated tower, with a bastion and two circular towers. Included a dry moat and a drawbridge.
1066 c: Owned by Sir Roger de Curcelle, son of Wandril de Leon.
1066 After: Owned by William Malet (Maulet) who fought at the Battle of Hastings. He had two sons, Robert and Gilbert.
1071 c: Gilbert Malet inherited when William Malet died. Gilbert was made High Chamberlain of England.
1100 c: Owned by the Malet family.
1100-1135 During: Gilbert Malet sided with Robert, Duke of Normandy. He had his lands taken and was banished from England.
1172 Baldwin Malet (2) was born at the castle.
1191 Baldwin Malet (3) was born at the castle.
1197 Baldwin Malet (1) died at the castle.
12th C The Malet family were reconciled with the King and their lands given back. Baldwin Malet (1) married Emma, daughter of Ralph de Neville.
1230 William Malet was born at the castle.
1250 Baldwin Malet (4) was born at the castle.
1272 John Malet was born at the castle.
1279 Baldwin Malet died.
1284 Baldwin Malet (5) was born at the castle.
1287 John Malet died.
1310 John Malet was born at the castle.
1335 Baldwin Malet (6) was born at the castle.
1343 Baldwin Malet died.
1349 John Mallet died.
1394 Hugh Malet was born at the castle.
1395 Phillipa Malet was born at the castle.
1682 Bought by John Percival, 2nd Earl of Egmont.
1751-1755 Built by John Percival.
1807 Improved by the 3rd Earl of Egmont.
1834 Sold to Nicholas Broadmeade, who demolished most of it.
19th C Mostly demolished.
1932 Most of the parkland turned into a golf course.
1964 Field Investigation.
20th C Built on.


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Molecular Level Process
Cloned Cows
Cellular Cloning Info
The Human Cloning Debate
Navigation Menu
What is Cloning
Reproductive Cloning Process
Recombinant DNA Technology
Dolly the Sheep
Stem Cell Research
Dolly The Sheep
Cloned Species Info
Human Cells
Ethical Issues
Cloning Plants
Replicating Extinct Species
Endagered Species
Cloning in Science Fiction
Biological Engineering
Alzheimer's Vaccine
Drug discovery
Stem Cell Research
Although many people have a superficial understanding of the concept of human cloning and the issue of stem cell research, the technical aspect of this process is largely ignored. While the reproductive side of cloning has drawn a lot of criticism by both industry experts and other organizations, the medical use of therapeutic cloning may be one area where the technology can be used in a positive manner. To learn more about the subject, a person should start with researching stem cell research and how the stem cells are used in the therapeutic cloning process.
Basically, stem cells are found in every living organism. These are the base level cells that are able to replicate themselves and form more complex structures, such as body organs in a human. Mammals have two types of stem cells, embryonic and adult models. The former group is responsible for developing a mammal to a mature state and the secondary group is responsible for repairing the body after maturity has been reached. Because researchers are still learning about stem cell roles in the body, it is thought that the introduction of these cells could be used to treat a wide variety of medical ailments by pushing the body to repair itself.
In fact, there are already some uses of stem cells that are recognized as beneficial to a patient. When a person has leukemia, one of the more advanced treatments is a transplant of bone marrow that helps slow the debilitating condition of the person. Researchers believe that the cultivation of stem cells could give more possible treatments to those patients that have suffered a stroke, have Alzheimer's or Parkinson's disease, or a number of different disorders and problems. Still, not everyone agrees on the issue of stem cell research and many that are against the study argue that it could easily cause cancer in patients. Until more research has been done on this sensitive topic, the controversy will continue.
© 2002-2011 bioarts.com All Rights Reserved.

subset: commoncrawl


text:
Dualit Espressivo coffee maker
The basics
Dualit's 15-bar coffee maker is one for kitchen fashionista thanks to a classy chrome and cast metal body.
The Dualit backs up its beauty with Thermobloc tech to deliver hot water and steam on demand, extra cup height clearance and a delivery system that will handle ground coffee or espresso pods.
Five amazing retro consoles revamped for 2013
The good
The Espressivo is not a machine to be hidden away – its gorgeous stainless steel and cast metal body will raise diners' eyebrows before they've even had a sip of its wares.
Fortunately, the coffee's also good – the controls on the Dualit are simple, solid and a joy to use, and with a little practice, you will be dispensing perfect espressos with ease.
Coffee temperature is also bang on, thanks to the Thermobloc system, and there's no hanging about waiting for steam to percolate. There's also a high dispensing nozzle, for anyone who wants to fill up more than an espresso cup.
The bad
The Espressivo is a tad on the noisy side once it gets going, although the sound is reassuring rather than alarming. We also found that this machine was a bit of a dripper – use it regularly and that drip tray will be full in no time.
Given the generous height of the dispensing nozzle, it remains a mystery why the frothing nozzle remains on the positively stumpy side.
Meet the first ever remote control ball!
The bottom line
Quite simply the best-looking coffee maker of its kind, the Dualit Espressivo is as classic as a Vespa and almost as much fun to take for a spin.
User comments (22)
hairytooth27 March 2010
I've lived with this machine for eight months and it is a joy. For a quick jolt in the morning or a long latte on a Saturday, this thing churns out consistently good coffee, with a thick crema and well frothed milk. I'd recommend it to anyone who likes real coffee.Report as inappropriate
radioboy31 August 2010
The large dial on the front can get extremely stiff after use and takes a strong hand to free it up again. I've had it a year now and it does make a lovely crema and it heats up very quickly.Report as inappropriate
Trevor Hames16 October 2010
Great machine. I also have the Delongi bean to cup machine which is more convenient, but the Dualit is excellent. Higly recommend it as a less expensive option.Report as inappropriate
Dabsholt26 December 2010
Espressivo - great crema. Not pleased with one major drawback (or is it a fault?). When the Filter Holder is removed the filter cup is totally sodden and you have to dig out the grains with a spoon. On my previous machine this was always almost-dry after switching to steam, and the grains could be simply tapped out as a single lump out of the filter cup (like a jelly mould). Is the sodden result normal?Report as inappropriate
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jess07 February 2013
Stopped working after 6 months and Dualit wouldn't repair. Extremely poor Customer Service. We were told it was probably a limescale problem and not their fault. Warranty was worth nothing. Was great until it stopped working but expensive coffee if it only lasts 6 months. Wouldn't buy any Dualit product with that attitudeReport as inappropriate
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garvey07 February 2013
Absolutely awful customer Service. Broke down after 2 months and Dualit wouldn.t repair. Major problem with limescale.Report as inappropriate
harryj11 February 2013
Great until stopped working then as other reviews have commented Dualit won't repair. Never experienced this sort of problem with anything still under Warranty. I will be buying a Baby Gaggia, great reviewsReport as inappropriate
angela kinane23 February 2013
Makes great coffee and is quick. It is a shame that the coffee grains are left so wet and harder to clean out. Instead of tapping them out into the compost bin they have to be washed down the sink.Report as inappropriate
Clondra25 June 2013
My Espressivo which is my pride and joy, broke down after 9 months (my fault, I live in a hard water area and didn't descale properly. I contacted Dualit who couldn't have been more helpful and offered to repair if I returned it. The repair cost £20 the return carriage to Ireland £15. Now that's what I call service given that I caused the problem in the first place. I now descale fortnightly!Report as inappropriate
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text: Dr. Vijian Dhevan obtained a masters degree from Stephen F. Austin State University in 1997. Following his postgraduate research, Dr. Dhevan joined the Nikon Digital Imaging Division where he developed new imaging devices for use in academic and clinical settings. In 2003 he enrolled at Texas Tech University receiving his medical degree and an MBA in Health Organization Management, completing his residency in general surgery at Southern Illinois University. With a focus on applying laparoscopic and minimally invasive solutions, combined with long-term experience in endoscopy, Dr. Dhevan provides well-tested, practical options for a patient's surgical needs.


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Wood to play 2nd pro season in Italy
Kokomo's Brandon Wood announced Wednesday that he will be returning to Europe to play a second season of professional basketball overseas.
Fresh off of a Hungarian Cup championship with Albacomp in his professional season, Woods announced Wednesday night on his Twitter account that he will be "Headed to Florence, Italy this season to play for Firenze in their first season in Lega Due Gold!"
Firenze spent last season in Lega Due Silver. Lega Due is the second-highest level of professional hoops in Italy behind Serie A.
Post 6 seniors open regional play Friday
The Kokomo Post 6 American Legion senior baseball team will open regional play Friday at 4 p.m. against Highland Post 180 (19-8) in the opening game of the double-elimination tournament at Plymouth's Bill Nixon Field.
Post 6 secured the top seed from the Kokomo Sectional last weekend when Richmond Post 65 opted not to return to Highland Park and play the championship round with the No. 2 seed already guaranteed to them. Richmond was supposed to face the top seed from the Plymouth Sectional, Bristol post 143, but will not play in the regional due to no longer having enough players to field a team.
As a result, the host team, Plymouth Post 27, will take Richmond's place in the tournament. The Post 27 Diamond Spiders will face Bristol Post 143 in the nightcap Friday at 7 p.m.
The losers of Friday's first round will play an elimination game Saturday at 10 a.m. The winners of Friday's games will follow at 1 p.m., with the loser coming back later in the day to face the winner of the first elimination game at 4 p.m.
The championship round of the tournament will be played Sunday at 1 p.m., with an if-needed game to follow directly afterward.


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When a 12-year-old Griffin student saw the Angle Tree and the local Walmart he was overcome with emotion.
Matthew Morris couldn't believe that young children were asking Santa Clause for necessities like underwear and socks.
"I was sad and I broke down. There is no reason for anybody in world to have to ask for things such as underwear and socks," Matthew said. "Children should be asking for toys at Christmas."
The Griffin Christian Academy seventh grader decided to find a way to help the children get clothes and toys. He sold his TV and many of his own toys to raise money. He raised about $300.
But when he took his plea for help to Facebook and YouTube, the donations started pouring in. As of Wednesday he had raised an additional $1,500.
"I was amazed because so many people were helping," Matthew said. "That is more than anything I've ever asked for. I thank them for that."
Matthew's parents Aaron and Melanie Morris said they taught their son to always think of others first.
"Obviously he's better at that than I could have ever hoped to imagine," Melanie Morris said.
It turns out Matthew has a deeper connection to the children in need.
"We used to live in a tight money situation. And it was really hard. I know what that's like," Matthew said.
The family will accept donation of new toys and clothes up until Friday morning.
They plan to take those donated items to the Salvation Army on Friday
If you would like a link the family's Facebook page click below.
Copyright 2012 WGCL-TV (Meredith Corporation). All rights reserved.
A 10-month-old accidentally locked himself inside a hot car, and his mom says a 911 dispatcher didn't immediately send help.More >
A 10-month-old accidentally locked himself inside a hot car, and his mom says a 911 dispatcher didn't immediately send help.More >


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BEST BETS: Fun things to do in and around La Jolla this week
Ring Those Bells!
The Short Attention Span Series of the UCSD Arts Library will present a free, musical offering with refreshments from 12:30 to 1 p.m. Wednesday, Dec. 15 in the Seuss Room of Geisel Library. Bells from around the world will be heard via live feed, historic recordings, and in person with host University Carillonneur Scott Paulson. The Teeny-Tiny Pit Orchestra will play seasonal tunes and story lady Melanie Treco will read a special tale. (858) 822-5758. email@example.com
Eggs-cellent Holiday Crafts
Mingei International Museum in Balboa Park will host its second annual Folk Art Studio offering participants the chance to make Romanian-style painted egg ornaments, decorative Tree of Life reverse glass paintings, and fashionable holiday cards from 1 to 4 p.m. Saturday, Dec. 11. Instruction and materials will be provided. Reservations are $12-$15 at www.mingei.org/programs or (619) 239-0003, ext.405.
Young Voices
"Fum, Fum, Fum," a concert of contemporary holiday music, Old World carols and audience sing-along with all the ensembles of the San Diego Children's Choir will be held at 3 p.m. Sunday, Dec. 12 at St. James By The Sea Episcopal Church, 743 Prospect. Tickets at the door: $14 adults; $7 kids age 12 and younger. (Auditions for the spring semester will take place Dec. 11 and 21 and Jan. 5 and 6. To reserve a spot, call (858) 587-1087. No auditions are required for the Preparatory Choir. The Choir is open to boys and girls, ages 6-18.) sdcchoir.org
Meilleurs Voeux!
The world-famous Baroque chamber group Aulos Ensemble will present "Joyeux Noel: An Evening of French Baroque Music," 4 p.m. Saturday, Dec. 11 at St. James-By-The-Sea Episcopal Church, 743 Prospect. This intimate concert, the second in the 2010-11 St. James Music Series, offers a rare opportunity to hear works by François Couperin, Jean-Philippe Rameau, Michel Corrette and Claude-Bénigne Balbastre – all as they would have been heard in the 1600s and 1700s on authentic period instruments. Tickets are $25 at the door or online at http://www.sjbts.org. Aulos Ensemble, a five-person instrumental group, was formed at New York's Juilliard School in 1973.
Mistletoe Mayhem
How can Junie B enjoy the holidays when Tattletale May keeps ruining her glee? See what she has in store for her in the San Diego Junior Theatre premiere of "Junie B in Jingle Bells, Batman Smells!" 7 p.m. Fridays; 2 and 4 p.m. Saturdays and Sundays through Dec. 19 at La Jolla YMCA Firehouse Theatre, 7877 Herschel Ave. Tickets are $11-$14 at (619) 239-8355 or juniortheatre.com
Scene-ic Sounds
A live music/cinema event "Flood Tide: Remixed," is set for 7 p.m. Dec. 17 and 18 at the Museum of Contemporary Art, 700 Prospect, La Jolla. Band members from Dark, Dark, Dark traveled down the Hudson River in the summer of 2008 on rafts/boats they made out of found objects and junk — a project conceived by the artist Swoon, who is a featured artist in "Viva la Revolucion" (the current exhibit at MCASD downtown). This has only been screened at a handful of museums around the country in advance of a featured film release. The concessions bar opens outside the Box Office at 6 p.m. Tickets $20; $10 MCASD members.
Something Completely Different
Jeffrey Combs stars as Edgar Allan Poe in the one-man play "Nevermore," 7:30 p.m. Dec. 9-12 at the North Coast Repertory Theatre, 987 Lomas Santé Fe Dr., Solana Beach. The show, set in 1848, attempts to recreate the public recitals that Poe presented during the last few years of his much-too-short life. Tickets are $25-$30 (858) 481-1055, northcoastrep.org
Catch the Spirit
Craig Newton will present a free, holiday concert for families at 4 p.m. Wednesday, Dec. 15 at The Riford Library, 7555 Draper. (858) 552-1657.
Merry Irish Christmas
Music, stories, dance and laughter to soothe Irish souls for the holidays, stars Darren Maguire, David Munnelly, the Kerry Dance Troupe and Orchestra and many others, produced by Kerry Records, 2 p.m. Sunday, Dec. 12, Balboa Theatre, 868 Fourth Avenue @ E Street, San Diego. Tickets from $54 at (619) 570-1170.
Related posts:
- BEST BETS to help you plan the week ahead, Dec. 2-11
- Doris Lee McCoy will address Circumnavigators Club on Dec. 9 in La Jolla
- Let Inga Tell You: What we need is The Clairvoyant Computer
- Let Inga Tell You: Zhu Zhu hamsters — from here to obscurity
- Let Inga Tell You: When it's too much of a good thing
Short URL: http://www.lajollalight.com/?p=30540


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Softball hosts UNF for biggest twin bill of the season on Wednesday
Related Links
The JU softball team will be playing for a lot more than marbles when they kick off the final week of the season on Wednesday at 6 p.m. against cross-town rival UNF in an A-Sun doubleheader at the JU Softball Complex.
The Dolphins (36-14, 14-2 A-Sun), who host Stetson in the regular-season finale on Friday at 5 p.m., will just need to win two of their final four games to lock up the program's first A-Sun regular season title and secure the No. 1 seed for next week's conference tournament. The matchup against UNF will also count towards the annual SunTrust River City Rumble standings.
"We are excited to get back into conference play tomorrow night," said JU head coach Amanda Lehotak. "The UNF series is always an interesting series when you add the emotion of the cross-town rivalry into the mix. We feel that we are prepared and are looking to forward to getting back on the field after a week of no games."
JU is in position to take its first title after winning 18 of the last 20 contests en route to a program-best 36 victories. With two wins at home this week, the Dolphins can also tie the 2005 squad for the program record in victories (20) at the JU Softball Complex.
Last time out, the Dolphins posted a season-high 16 hits in the five innings to secure an 11-3 win against Bethune-Cookman in the final non-conference game of the season on April 27.
Junior Sarah Sigrest secured her 20th win of the season with eight strikeouts in 4.2 relief innings and junior Amanda Schmidt recorded a career-best six RBI to pace the offense.
The Ospreys (24-29, 8-10) swept the Hatters (19-29, 4-14), 5-0 and 6-1, in the home finale on April 30, but lost the final spot in the A-Sun Tournament to Mercer.
Lauren Pollack is leading the offense with a .292 average, while Mariah Reynolds has driven in a team-best 28 runs. Cortney Radke has picked up 22 of UNF's 24 wins in the circle, fanning a program-best 303 batters in the process.
Last season, each team battled to a 2-1 win in 11 innings during the doubleheader at UNF. Senior Katie Kelly had the game-winning single to help JU get the Game One win. The Ospreys have a 8-2 lead in the all-time series.
Stetson has only scored one run in the last four contests entering this week.
Chrissy Morello paces the Hatters with a .351 average and Meredith Owen have posted 81 strikeouts in 131.2 innings for a 7-12 record.
Last season, the Hatters swept the Dolphins in DeLand, Fla. and beat JU in the first game at the A-Sun Tournament to take a commanding 17-3 lead in the all-time series. JU's last win over Stetson was a 5-0 game one victory in DeLand on April 18, 2008.
Fans can follow the games on live stats and the UNF contest on video streaming through A-Sun.TV by logging into JUDolphins.com.
UNF SID TO HELP WITH ALABAMA DIASTER RELIEF: UNF softball SID and Alabama native Rod Black will be collecting supplies for the next three days to help with the tornado relief that hit his home state. Black was inspired to help those in need after learning of three friends who lost their homes and one who was killed. Fans can donate at the UNF/JU softball doubleheader on Wednesday or drop items off at the Osprey media relations office in UNF Arena. For more information, please contact Rob Black at 904-620-4025 or email through email@example.com.


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Westminster Parent Fund
Invest in your student's future through
Every day, Westminster guides students to think critically, to discover and create, to develop their full potential and lead, to expand their view of the world. A Westminster education prepares our graduates for a purposeful and rewarding life.
Creating this kind of future takes the support of everyone who understands the power of the Westminster experience. Through your gift to The Westminster Parent Fund, you support the academic programs, student research, arts, and athletics programs that prepare Westminster graduates to effectively change the world.
The Westminster Parent Fund is used to improve student life at the College. It also provides emergency funds to individual students who face unexpected financial needs.
Why the Parent Fund matters
· Educating each Westminster student costs 35 to 40 percent more than the tuition can cover.
· Westminster relies on parents and alumni gifts to raise over $3 million each year for the College's annual budget.
· The Westminster Parent Fund provides funds the College can use to meet immediate, important needs.
What the Parent Fund does
· Supports student research and exceptional professors
· Improves and diversifies student life at Westminster
· Supports student activities for every interest and sport
· Enhances safety and security for the campus
· Provides emergency funds to students with unexpected financial needs


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Wednesday's cold, damp weather led to a slow start for early voting, but the two campaigns for a new, $43.5 million bond issue to build a Johnson County Justice Center are warming up after a recent incident.
This past week, a Johnson County inmate was charged after intentionally breaking a spork in her jail cell.
The incident has sparked comments from jail opponents who believe a larger jail will only facilitate more arrests and the overcharging of offenders.
"It does illustrate the practice of multiple charging, which creates jail overcrowding," said jail opponent Jeff Cox.
The county attorney's office dropped the charges at the request of the sheriff, who admitted his deputy made a mistake in administering the additional charge.
Jail supporters say the incident is not representative of the types of charges those in jail are facing.
"If people are going to vote against the Justice Center because of a spork, I think they're really not looking at the safety, security, and space needs of the jail," said County Attorney Janet Lyness.
The current jail, Lyness said, is overcrowded.
The new proposal would build a jail with 195 beds and have room for growth. It would also have additional court space.
"If you look at the Johnson County jail, I think you'd be surprised how many are in there for serious felonies," Lyness said.
Opponents believe a facility should be built only to address the county's current needs.
"There are ways to solve this without building a large, new, maximum-security jail at large expense to the public," Cox said.
Early voting opportunities are available at the auditor's office.
The countywide vote is set for May 7.
Strange formation at bottom of Utah irrigation pond baffles farmers and scientists. John Hollenhorst reports.


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Your favorite feline companion can take comfort in Royal Canin Veterinary Diet Urinary SO Moderate Calorie Dry Cat Food! It is a vet diet for cats with or at risk of developing feline lower urinary tract disease, coupled with the predisposition for gaining excess weight. Royal Canin Veterinary Diet Urinary SO Moderate Calorie Dry Cat Food is designed to prevent the two major types of urolithiasis. It increases his/her urine volume, while decreasing the saturation of urine with calcium oxalate and struvite. It provides a nutritionally complete meal for your adult feline companion. With Royal Canin, you and your cat can breathe a sigh of relief!
*Please Note: Royal Canin Veterinary Diets now ship directly from the Royal Canin facility closest to you (via UPS ground only, expedited service is unavailable at this time). Royal Canin Veterinary Diets do not ship from our distribution centers and cannot ship to a P.O. Box, Alaska, Hawaii, Puerto Rico, APO/FPO or Canadian addresses. On average, orders are shipped in 24 hours and will take one to two days to reach your home. Please note that orders for Royal Canin Veterinary Diets will not be fulfilled until a copy of a valid prescription authorization is faxed to 877-894-5034 or e-mailed to email@example.com.
View all Royal Canin Veterinary Diets Cat Food
Chicken meal, brewers rice, corn gluten meal, corn, powdered cellulose, wheat gluten, natural flavors, chicken fat, salt, potassium chloride, monocalcium phosphate, calcium sulfate, fish oil, sodium bisulfate, vegetable oil, dried egg product, DL-methionine, fructooligosaccharides, glucosamine hydrochloride, choline chloride, monosodium phosphate, taurine, vitamins [DL-alpha tocopherol acetate (source of vitamin E), biotin, niacin supplement, pyridoxine hydrochloride (vitamin B6), D-calcium pantothenate, riboflavin supplement (vitamin B2), vitamin A acetate, thiamine mononitrate (vitamin B1), folic acid, vitamin B12 supplement, vitamin D3 supplement], L-carnitine, marigold extract (Tagetes erecta L.), trace minerals [zinc oxide, zinc proteinate, ferrous sulfate, manganese proteinate, copper proteinate, copper sulfate, manganous oxide, calcium iodate, sodium selenite], rosemary extract, preserved with natural mixed tocopherols and citric acid.
Crude Protein (% Min) 32.0
Crude Fat (% Min) 9.0
Crude Fiber (% Max) 9.0
Moisture (% Max) 9.0
Royal Canin has a comprehensive selection of high-quality prescription-only diets that treat the animal in addition to the disease. With exceptional palatability, the Royal Canin diets include all required nutrients to minimize clinical symptoms or promote recovery. Royal Canin's prescription diets are founded on the belief that animal health and good nutrition can only be achieved through a combination of innovative diets and professional veterinary counseling.
Royal Canin Veterinary Diets provide patients with the Best of Both Worlds - the scientific expertise of Waltham and manufacturing innovation from Royal Canin.


text:
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text:
Jai | April 20, 2012 6:56 AM
Looks interesting.
jingmei | April 20, 2012 12:38 AM
Wait to see the sparks among the characters of this film.
K | April 19, 2012 10:29 PM
This looks interesting, and Zach Gilford is a talented actor.
Also, I love seeing Gabrielle in varied roles; her acting seems to improve with each one.
brandon | April 19, 2012 9:32 PM
good! i cant wait to see this film! the performances look good based on the trailer


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yes, destroy all the heritage you have, M4 great idea, what does M3 mean to anyone, V6? great idea who associates BMW with straight sixes? 6 into 1 headers with sequential twin turbos? the Germans are on acid.
I agree with you to some extent… But BMW has proven they and their customers can weather the storm of hatred from purists who would let something like a single digit or turbocharger get in the way of progress.
BMW do what they do the way I do what I do, if you have to adapt to be the best, then get on with it!
PS: its not like the M3 wont exist anymore, it will just be a 4 door version while the M4 is the coupe. Still the best family mans super saloon around!
Why not just solve the problem – less doors = lower number, hence the coupe would be the M3 and the 4 door the M4?
Everyone is happy… aren't they?
Makes sense to me.
This would break the BMW numbering system even more. BMW gives odd numbers to the passenger cars (eg 1, 3, 5, X, 7 series) and even numbers to the sports cars (eg Z4, 6, X6, 8 series).
So really to stick with this naming convention they should call the sedan M3 and the coupe M4.
I think Audi might mention something if they did that, A4 vs 4 series as sedans might create a bit of confusion.
It also has the potential to take away a bit of its identity in comparison to A4 as well.
I can't see BMW developing a turbo V6 when they already have sweet straight 6 turbo engines. Unless they are working on the turbo-in-the-valley idea from the TwinPower V8? In that case, I'd think it would be more logical to just use the existing TwinPower v8?
I can't see BMW dropping the straight 6 after so long, it would be a shame if they did.
They are… Its basically the V8 with two cylinders chopped off. (90 degrees apparently, but that is only what the people say who got hold of the blueprint of the patient BMW is filing, so I cant say for sure, and I think that means it would need balance shafts so im certainly not sure if they are committed to that design).
But it shows bigger turbo in series behind a smaller turbo, rather than two turbos in parallel, inside the V configuration.
The only reason in my mind to abandon the straight six is crank vibes. Long crankshafts like all long straight engines stress their center bearings much more than shorter crankshaft designs. Its possible BMW will use the M3/4 as a platform to introduce V6 power to their customers, without upsetting the fans of the straight six engines and keeping them in production for the smaller BMW models.
IE: Nobody will complain about a V6, if it comes out in the M3 and wipes the floor with everybody. But can you imagine all the moaning and groaning if they brought out a V6 in the smaller BMW models. They would never hear the end of it…
Yep, that's exactly what I thought they would do if they were bringing in a V6 – lop 2 cylinders off the existing TwinPower V8. So in that case we'd be looking at a 3.3L V6 with about 308kw and 510nm?
I'm not sure crank vibes would be the problem – what with the I6 being a very well balanced configuration and previous engines like the E46 M3 revving to 8000rpm +. I'd be more inclined to think that the V design caters better to TwinPower idea – very short distance from the exhaust valves to the turbo(s).
Possibly, but dont hold me to that… I would still prefer a 60 degree V6 as it wont need balance shafts.
Its possible too with that sequential turbo configuration that the V6 could do much better than the Twinpower V8, where emphasis is on drivablity and not top end power.
Im not saying that you cant engineer out the inherent flaws of a straight six engine, BMW M division really does know more than anyone else how to get the best out of its straight sixes. But yeah, a V6 wouldnt be 'such' a bad idea for reasons you gave; shorter turbo manifolds, ect, and crank vibes either way.
Saw a video clip this morning of them testing the new M3… It's definitely going to be a six!
A V6 based on the V8 would actually make sense. The 4L V8 in the E9x M3′s was basically the 5L V10 from the M5 with two less cylinders.
I just wish they would look at other options to keep that 4lt V8 alive in the M3, like a Kers type system, maybe. Porcshe are able to put a mega V8 into the upcoming 918 and still acheive better than prius fuel economy @about 3lt/100.
The 1 series has got the turbo six covered, and the M5 has the twin turbo V8, so a naturally aspirated V8 would be perfect in the next M3. it would be nice to still have at least 1 n/a engine from the M group.
Why don't Germans have many n/a engines??
Because you can achieve better emissions and fuel economy with induced engines while still maintaining a high performance output. I think they also carry a slight weight reduction.
Mercedes are phasing out their 6.2 V8 for TT 5.5 V8.
M5 losing V10 for TT V8
RS6 TT V10 for TT V8 (most likely)
Look at F1, going to T V6 (will eventually be a motocycle engine at the rate they are dropping engine size).
F1 is a whole different kettle of fish. Remember the days before forced induction was banned? Crazy amounts of power from 1.5L turbo engines. The new V6′s will be rev limited to 15,000 rpm to keep the power levels sane (probably a raft of other design restrictions too).
Yes but formula 1 hates innovation eg 6 wheeled car, the fan car.
Its a bit saddening to see BMW essentially abandoning their performance heritage throughout the range simply in the name of progress. I was hoping that the 3 Series would have been a last bastion to keep the M heritage of Soaring revs, and NA engines alive…but no. I see why they are doing it, i just wish that they werent.
I agree. Like you say though, it's easy to see why they are doing it – forced induction allows lighter, more efficient engines with fatter torque curves. Also consider BMW's competition – they probably need to do this to stay competitive with Audi and Merc.
I just can't believe that BMW are even contemplating a V6 considering their heritage with the straight 6. Try and find another 6cyl that is as smooth as a BMW straight 6. Plus I haven't heard a V6 engine that even comes close to the wonderful noise made by their straight 6. All you have to do is youtube the E46 M3 CSL to see why. The noise that thing makes causes the hair on the back of your neck to stand up.
It will be a sad day if/when they do say goodbye to the engine that has been such an integral part of BMWs for decades…


text:
Financial Daily from THE HINDU group of publications
Wednesday, November 30, 2005
Star Group keen to enter FM radio biz
THE Star Group on Tuesday, reiterated that it is keen on entering the FM radio business but said a decision on prospective partners would be based on how many licenses they get and the content plan. On the sidelines of the India Economic ... More
A Zee `smile' for comic game shows
TO set itself apart from the plethora of game shows, Zee Smile plansning to launch a talent show on the comedy platform. Speaking to Business Line, Mr Nitin Vaidya, Business Head, Zee Smile, said: "We are planning to launch a talent ... More
Cobra Beer planning $10-m brewery
'Need for national marketing policy'
THERE is a need for a national marketing policy as retail accounts for 11 per cent of the country's GDP, said Mr Ajay Dua, Secretary, Department of Industrial Policy and Promotion, Ministry of Commerce and Industry. Mr Dua was addressing a ... More
It is time for ads to board A-I Express...
THE exotic and iconic images that adorn the tailfins of Air-India Express aircraft will soon be complemented by logos of banks, moneychangers or any others willing to pay for some unique ad space. Like several other low-cost airlines, A-I ... More
Rediffusion DY&R floats design consultancy arm
Guardian Holidays offers 50% discount on companion fare
THE Pune-based Guardian Holidays is offering a smart-couple offer wherein the first customer travels fully paid while the companion gets 50 per cent off on the cost. "This means the companion pays just half the cost and accounts for ... More
Tata Motors Daewoo market share in South Korea up 4%
TATA Motors said on Tuesday that following the takeover of Daewoo's commercial vehicle business, its market share in South Korea had increased 4 per cent to 30 per cent since it started operations over a year ago. An official said Tata Motors ... More
Channel 7 looks to boost market share
CHANNEL 7 is looking at increasing its market share to 15 per cent in the coming months and be among the first four channels in the news genre through its news-plus programming. Speaking to Business Line, Mr Siddartha Gupta, Director, ... More
SMART Tech unveils upgraded interactive white boards
SMART Technologies, global market leader in interactive whiteboards, has launched its latest version of Smart Board 600 series, an improved version of its earlier model. The new modelhowever, uses the same software built for 500 series, has ... More
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Barons sign Cheechoo to tryout
The Oklahoma City Barons have signed forward Jonathan Cheechoo to a professional tryout contract, general manager Bill Scott announced today.
Cheechoo, a 6-foot, 200-pounder from Moose Factory, Ont., skated last season with the Peoria Rivermen where led the team with 25 goals and scored 56 points.
Originally a second-round draft choice (29th overall) of the San Jose Sharks in the 1998 NHL Entry Draft, Cheechoo is a veteran of 501 games in the National Hockey League. His breakout season came during the 2005-06 campaign when he recorded a team-leading 93 points for the Sharks. That included 56 goals, which earned him the Maurice "Rocket" Richard trophy as the league's top goal scorer. He also played in the 2007 NHL All-Star Game.
Cheechoo, 32, has also played 287 games in the AHL with Kentucky, Cleveland, Binghamton and Peoria, notching 107 goals and 129 assists for 236 points. He was named to the AHL All-Rookie Team and skated in the AHL All-Star Classic in 2001.
- Education, drug testing program implemented
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- 2014-15 AHL schedule unveiled
- Holland looking to make the leap
- Namestnikov enjoys NHLPA Rookie Showcase
- Khokhlachev ready for NHL shot
- Lehigh Valley signs Hextall to AHL deal
- Former AHL player coping with ALS


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It's been said before, but it's hard to make mock drafts and decide what team is going to take what player with all these different variables. Who is going to be signed to a team in free agency greatly changes the draft. What trades take place on draft day change what a team is doing. Lastly, some players get traded on draft day can all kill what you think is going to happen with your team in the off season. I'm going to talk about some player moves that are specific to the Jets and some that are just NFL moves.
I think out of these 5 moves, I'm gonna nail about 4. I'm going to give you the offseason move, or trade, and my reasoning behind it. I don't have any inside knowledge, but I'm going to use logic and past examples as my reasoning. Now on to the topic at hand.1. First up is Payton Manning.
He's the hottest topic. A while ago it was will he stay and mentor for a few seasons, or will he go. The current news around the NFL is that he's definitely going to be released before March 1st. Since he's not being traded, he has the opportunity to go to the team of his choice. Some people have mentioned the Jets. I have bad news for you, it won't be New York.
Consider that his salary this season was 28 million if he doesn't get cut. He is going to demand a large number, and even if it's not 20 million it's going to be a huge number. Also consider, he's not going to go to a team that is a perennial cellar dweller. If he has his choice, he is going to go to a veteran win-now type of team, similar to what Favre did with the Vikings.
Payton Manning is going to be a Washington Redskin. Before you laugh consider the facts. The Redskins started last season 3-1 and in first place in the NFC East. They started the season before that 4-0 with McNabb. They are fast out of the gate and fade down the stretch. The Superbowl NFC representative NY Giants were 9-7 and won the conference, while the Redskins were 5-11 in last place. The Cowboys and Vikings were 8-8 respectively. There is no run away dominant team, and winning the division is just a Manning away. The road through the playoffs is easier in the NFC as well. Add to that, he would be able to play against brother Eli Manning 2x a year.
The owner is Dan Snyder. He pulled the trigger on a 100 million dollar Albert Hainesworth deal. $100 million for a defensive tackle? I think a quarterback with a big number is not that big a deal to him, as he desperately wants to field a winner. Consider the coach. Mike Shanahan coached the Broncos to 2 NFL titles with a veteran and hall of fame QB about to retire in John Elway. This is a good team with a good defense and bad offense that had a losing record. If you throw in Dan Snyder tossing money around they are easily a Payton Manning away from dominating the NFC East next season. Throw in the fact that they have no money tied up in quarterbacks Rex Grossman and Jon Beck they have the cap space and the empty position sitting waiting for him.
Also consider there are rumors of them in the running to move up to draft Robert Griffin III. They can get Manning without using a draft pick, and promise him some help in the 1st round of the draft via Justin Blackmon or whoever he wants. They currently have the 6th pick. They can still draft a QB of the future in Nick Foles or Osweller in the 2nd round, and Manning could probably bring long time pal Reggie Wayne along to Washington. This would suddenly give them Manning, Reggie Wayne, Santana Moss, and Blackmon to go with a good head coach and a good defense. It also allows them to draft a 2nd round highly rated QB to groom behind Manning for 2 or 3 years with no pressure.
2. Jets Pass Rush
The unwritten rule is that the Jets every year need pass rushers. Let's look at the recent Jets history. In 2010 they needed corners because they had just lost to the Colts in the AFC Championship. In a knee jerk reaction they traded for Antonio Cromartie, and drafted Kyle Wilson. They double dipped to ensure they could handle what they wanted to do on defense.
This season the consensus is that they need a pass rusher. I believe as history has shown they will again double dip. Once in free agency to try to cover the open spot left by Bryan Thomas and once in the draft. The combination of best price and most production in free agency comes in the form of John Abraham of the Atlanta Falcons.
If you don't remember him, he is the 6'4 260 pound defensive end that ran a 4.4 in the combine and had multiple 10+ sack seasons before he was traded to Atlanta. He has played 6 years in NY and another 6 in Atlanta. When he was with the Jets he was injury prone and subject to groin pulls and things. The last 5 years with Atlanta he has missed a total of 4 games. He's over his injury issues and he's an old veteran that can take the left outside linebacker spot from BT. He's 34 now, but last season he notched 9.5 sacks and 4 forced fumbles. In fact the last 4 seasons he lowest sack total was 5.5, and he notched 9.5 or more the other 3. The Falcons aren't going to make the hurdle in the NFC South, and the Jets are going to sign him to a deal similar to what they gave Jason Taylor in 2010.
Here's the double dip part. In the draft with the OLB spot (pass rusher) covered, they can go with the best player available. I still believe they will take a pass rusher and double cover the trouble spot. I think they like Courtney Upshaw, but will instead draft Nick Perry. He is similar to John Abraham when he came out of college. This turns the anemic Jets pass rush from a liability to a positive. They can rotate Calvin Pace, John Abraham, Nick Perry, and Aaron Maybin, and get a solid pass rush all game long. The days of Jamal Westerman and Garrett McIntyre are a thing of the past.
Empty slot with Bryan Thomas departure+Need of pass rusher+familiarity with the team
Sione Pouha played a great season for the Jets. Nose tackle is one of the hardest positions to fill in the NFL, do the the size, skill, and durabilty needed to hold up in a 3-4 system. The Jets are rumored to have about 8 million in cap space currently before signings and re-signings. The resigning of Pouha is 50/50. He is a great player and does exactly what they need. However he is 32 and is getting ready for a multi year deal. I don't see the Jets giving a 32 year old a 4 or 5 year contract unless it has a low signing bonus or is incentive laden. Pouha, probably and wisely won't go for either. He has never indicated he would like to play anywhere else, but due to the skyrocketing prices of starting nose tackles he could easily get between 6-8 million for a team in dire need of one annually. Darnell Dockett for example is an average 3-4 nose for the Arizona Cardinals. He has a 6 year 56 mil deal. Vince Wilfork is in a 5 year 40 mil deal.
Where is there a team that plays a 3-4 defense that is in need of a good run stuffing nose tackle? The Pittsburgh Steelers come in and scoop him up. They currently have 34 (soon to be 35) Casey Hampton starting at nose for them. He had some good years, but is long in the tooth and more injury prone than Pouha. The Jets try to keep him, but the Steelers who already took Cotchery will take Pouha and he will start for them for the next 3-5 years.
The Jets will in turn move practice squad player Martin Tevaseu to step in and play the nose. For the last 2 seasons he was the last round of cuts in preseason. This year he steps off the practice squad, much like Pitoitua did this past season. The combination of Kenrick Ellis and Tevaseu will fill the void left by Pouha.
4. Matt Forte
Matt Forte is the premier running back of the free agency class. The Bears offense is almost nothing without him. The Bears and Vikings were the front runners for the NFC north 3 years ago, and now the Lions and Packers are the front runners for it every year. Forte even with a leg injury, has never had higher value, and is in place to go wherever he wants for some pretty good money.
Odds are that he doesn't stay in Chicago. I say that because the Bears do not have a track record of holding on to players when their contract expires. They have really only held onto a handful of guys, and most of them were defensive starters. My thinking is that he goes to the Detroit Lions who make a pretty good offer for him.
The reasoning? It strengthens the Lions while weakening the Bears (taking away their only play maker). If you watched the Lions and the Saints you saw the Lions score and score and score. They do this well. What they don't do well is run the ball, or slow the game down. They need to be able to hold onto a lead by controlling the clock and throwing short passes to the back to keep the defense off the field. These are the things that Matt Forte can bring them along with stability at the position. By signing Forte, they can keep the offenses of Green Bay off the field and take the Bears out of contention. Instead of Forte putting points on the Lions twice a year, he helps give them a running game for the next 5 years. He also lets them stop calling guys like Jahvid Best and Kevin Williams starters.
Mario Williams is 6'6 and 290 pounds. He was written off early in his career and now is reveared as of late. He's started as a 4-3 end, and moved to a 3-4 end, and most recently has been a linebacker in a 5-2 alignment. He's done it all, and done it pretty well and he's only 26 coming off an injury. He is sure to command big dollars.
My guess is that he does not return to the Texans. He didn't play the last 11 weeks of the year, or in the post season and the Texans defense continued to chug along. JJ Watt and Ryan Kerrigan are young, and the system is like a machine adding parts to fit and play well. I think they will not resign him, in order to re-sign future players. Mario will have the freedom to go where he wants and he picks a system where he can continue to produce.
There are certain teams that do a specific thing. The Giants always draft defensive ends that pass rush. The Packers always draft receivers. The Jaguars always bring in lineman. I think the Vikings are like that with defensive lineman. They brought in Jared Allen, but lost Ray Edwards to the Falcons. They still ranked top 3 in the NFL in sacks with 50 on the year. On the year they were 11th against the run, but 26th against the pass. They gave up 4,000 yards passing and 8 yards per pass play.
That speaks to the fact that the secondary is not so great, but they like to have attacking defenses. Mario WIlliams taking over at left defensive end and Jared Allen at right end improves the pass rush and the run game. In addition the Vikings have the #3 pick in the draft. Lots of people, including me have them drafting a cornerback like Morris Claiborne of LSU. In a division with the Lions and Packers that like to throw, the addition of WIlliams and drafting of Claiborne helps to negate the passing attacks of those teams and gives them a chance to grind it out with Adrian Peterson and Toby Gerheardt while Ponder improves.
There you have it. Just 5 things I think you will see this off season to help teams before the draft comes around. I didn't include other moves like Vincent Jackson finally getting a long term deal in San Diego or Desean Jackson going to Miami. These are just my thoughts on what you will see based on what I think are certain teams tendencies over the years. Thanks for reading


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Raymond Laurence Hadler, 90, Greensburg, passed away Friday, Nov. 16, 2012, at the Heritage House of Greensburg.
The son of Conrad and Flora Wiedemann-Hadler was born Dec. 24, 1921, in Decatur County. On Oct. 12, 1946, Raymond married Lois Morgan in St. Paul, and she survives.
Raymond served in the United States Army Air Corps during World War II. He was in the CBI – China Burma India Theatre.
Raymond worked for 33 years at Bohn Aluminum, Greensburg, until his retirement. He also attended the First Church of God and enjoyed the outdoors and spending time with his family.
Also surviving are daughter Beverly Anne (Darrell) Grimes, Greensburg; sons Douglas Duane (Elizabeth) Hadler, Jonesborough, Tenn., and William Gene (Sue) Hadler, Greensburg; seven grandchildren; six great-grandchildren; and several nieces and nephews.
Ray was preceded in death by his parents; sisters Mildred Cox, Iva Dice, Viola Huber, Velma Thackery, Lillian Witkemper and one infant sister; and brothers Harley Hadler, Earl Hadler and one infant brother.
Visitation for family and friends is Tuesday, Nov. 20, from 4-8 p.m., and the services is Wednesday, Nov. 21, at 10:30 a.m. at Gilliland-Howe Funeral Home, Greensburg. Burial will follow at Zion Cemetery there.
Memorial contributions may be given to Zion Cemetery Association. Online condolences may be made to the family at www.gilliland-howe.com.
Raymond Laurence Hadler, 90
Raymond Laurence Hadler, 90, Greensburg, passed away Friday, Nov. 16, 2012, at the Heritage House of Greensburg.
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Question: How long is yeast good for?
Opened packages of dry yeast (active dry or instant) can be stored in the refrigerator for three to four months. If your yeast is older than this, it may still be good. Proof your yeast to find out if it's still active by adding 1 teaspoon of sugar and 2-1/4 teaspoons of yeast (one envelope) to 1/4 cup of warm water. Then, wait 10 minutes. If the mixture bubbles and develops a yeasty aroma, the yeast is still good.
Tip: Want to store yeast longer? Stick it in the freezer, and it will be good for years.


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Funding opportunities
Stem Cells for Treating Pre-Arthritic Focal Cartilage Defects
Funding Type:
Disease Team Research I
Grant Number:
Funds requested:
$18 028 444
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Arthritis is a disabling condition that afflicts 6 million Californians and costs our state nearly $32 billion a year for health care and lost wages. Yet arthritis remains an unmet medical need and its overall impact will increase steadily given that more of the population is aging and that the inability to maintain an active lifestyle has severe consequences for many aspects of health. Sixty million Americans are projected to have arthritis by 2020. In the absence of effective 'arthritis drugs', joint replacements offer some relief but have limited durability and are unsuitable for young patients. Other treatments that try to repair cartilage damaged prior to arthritis, such as microfracture of underlying bone or cartilage cell transplantation, fail to restore native mechanical and biological properties of the joint and do not avoid disease progression. For preventing arthritis, stem cells have obvious appeal, but directing them to synthesize a desirable cartilage matrix has proven challenging. We have made a fundamental advance in overcoming limitations to the use of stem cells for cartilage repair. We have developed a Product in which human mesenchymal stem cells (MSC) are grown alongside highly instructive juvenile cartilage cells. These cells are arranged in bilaminar cell pellets (BCPs), and embedded in a mechanically functional biomaterial composite. BCPs synthesize abundant articular cartilage matrix, adapt to the unique environment of the joint, and resist inflammation. The biomaterial composite retains the BCPs at the defect site and supports joint forces. Over time BCPs will secrete cartilage matrix and replace the biomaterials. We propose a focused plan to optimize the cell source and BCP interactions with biomaterials; establish cell banks; demonstrate feasibility, safety, and efficacy; and develop clinical trial and commercialization plans. Our goal is to accelerate translation of this novel stem cell-based therapy to provide an early intervention for preventing and treating arthritis. With support of a CIRM Disease Team Planning Grant, we assembled an outstanding team of experts from Academia and Industry with the experience and motivation to achieve our goal. The team leader is Director of an industry-collaborative center and an Orthopaedic Biomechanics Laboratory, and a pioneer of protocols for turning stem cells into cartilage. Our Academic partners bring world-recognized leadership in stem cell and skeletal biology, and clinical expertise in orthopaedic surgery, including past clinical evaluations of other cell-based therapies. Our Industry partners have established products for clinical applications, and contribute expertise in cell sourcing, biomaterials, manufacturing, and regulatory processes. By combining the creativity and innovation of Academia with the pragmatic focus of Industry, our team is poised to meet the challenge of filing an IND within 4 years for a stem cell-based therapy for cartilage regeneration.
Statement of Benefit to California:
Approximately 6 million adults in California, or 27% of the population have some form of arthritis. This disease costs California nearly $32 billion each year, with an estimated $23.2 billion spent on direct medical care and $8.3 billion due to lost wages. The centers for Disease Control and Prevention projects that 60 million people nationwide will have arthritis by 2020. Osteoarthritis is a disabling disease that limits the ability to engage in the regular physical activity that prevents obesity, diabetes, and cardiovascular disease. Consequently, successful development of improved arthritis therapies will benefit a significant portion of the California population. Additionally, we anticipate that the management structure of this program along with the cell/matrix technologies can ultimately be applied to a host of other musculoskeletal diseases such as back pain, osteoporosis, and fracture repair. In addition to the health of Californians, cell based therapies for arthritis and other musculoskeletal conditions provide a huge commercial opportunity for California industry. Credit Suisse has estimated that the growth potential for the orthopaedic industry focused on hip and knee treatment is positive, with projected global sales expanding from $9.6 billion in 2006 to $13 billion in 2011. The orthobiologic market that includes regenerative technologies currently accounts for roughly 12% of the worldwide orthopaedic implant market and is the fastest growing segment, at 20% annually. Our Team partners with several California companies who will directly benefit from this effort. Clearly their economic success will provide employment opportunities for Californians, tax revenue for the state, and help maintain California as a world leader in biotechnology research and development. This work also aids the research enterprise of California universities by augmenting our competitiveness for NIH funding. This, in turn, brings the brightest scientific talent to the state, fuels innovation, and ensures continued California leadership in the biotech industry. Given the significant unmet clinical need, market opportunity, and rapidly evolving technologies, we anticipate that stem-cell based therapies for arthritis will be realized in the next 4 to 8 years. The CIRM Disease Team Award can assure that this important therapy with the potential to prevent the progression of osteoarthritis is developed in California.
Review Summary:
Osteoarthritis (degenerative arthritis) is a common, painful and debilitating condition with limited treatment options. It is caused by breakdown and eventual loss of articular cartilage (cartilage of the joints), often resulting from joint injuries. The objective of this proposal is to develop a stem cell-based therapy for repair of pre-arthritic focal cartilage defects in order to prevent progression to osteoarthritis. This will be achieved using co-cultures of autologous adult mesenchymal stem cells (MSC) and allogeneic juvenile chondrocytes combined in structured bilaminar cell pellets (BCP). The rationale is that the chondrocytes in the BCP will persist for a period of time and instruct MSC to differentiate into chondrocytes and secrete cartilage to repair the damaged joint. The BCPs will be embedded in a mechanically functional biomaterial composite consisting of a hydrogel/scaffold carrier, designed to deliver and retain BCPs at the knee cartilage repair site as well as possibly provide mechanical stability during the recovery process. Thus the therapeutic candidate will consist of BCPs embedded in a biomaterial composite. Initial project goals include the development of protocols for isolating and expanding MSCs from either bone marrow or adipose tissue; development of a protocol for isolating juvenile chondrocytes; development of a manufacturing process for BCPs; and development of a hydrogel/scaffold with tensile properties similar to native cartilage. Subsequent goals include conducting safety and efficacy (proof-of-concept) studies in preclinical models. Early interactions with the Food and Drug Administration (FDA) will be conducted and FDA recommendations will be incorporated into the preclinical plan. A major criticism of this proposal is related to its complexity, since the proposed therapeutic candidate involves two cell types plus hydrogel plus scaffold. This poses significant hurdles in terms of manufacturing and clinical logistics and makes the regulatory path extremely difficult. A second major criticism involved doubts regarding the scientific rationale which was viewed as not compelling. A third problem was the lack of any proof-of-concept data with respect to disease-modifying activity. An Investigational New Drug (IND) application in four years was considered unlikely. Although the reviewers accepted that if successful, this project may yield a cell therapy that will significantly improve the outcome of patients with a debilitating disorder, they questioned the basic scientific premise that this complex product offers a significant advantage over other, less complex options. The complexity lies in the use of two cell types, autologous MSC and allogeneic juvenile chondrocytes, with a further layer of complexity added by the potential use of a hydrogel/ scaffold. Reviewers agreed that this is a high risk project, and while there is some scientific rationale for the use of this complex technology they were not convinced it has been effectively justified, since the design of relevant preliminary experiments was flawed. Although these experiments compared the BCP combination cultures to each cell type alone, they did not include the standard published condition, MSC plus TGFbeta. Therefore, reviewers found that the evidence favoring BCP over existing simpler approaches (such as TGFbeta-stimulation of MSC alone), is unconvincing, and suggested that there may be no need to move from a simple single cell/growth factor system to a complex two-cell autologous/allogeneic system. Reviewers also had doubts regarding the conclusion that BCP co-cultures promote chondrogenic differentiation of MSC as evidenced by the detection of chondrocyte-specific transcripts in the cultures. They commented that it was unclear if those transcripts were, in fact, derived from the juvenile chondrocytes in the co-culture rather than from differentiated MSC-derived cells. Taken together, these doubts regarding the basic scientific rationale were considered to be a major weakness of the proposal. Reviewers felt that the plan is logical and most of the milestones are timely and meaningful. The proposed clinical indication, treatment of small, non-arthritic focal lesions, is an excellent context in which to test the underlying assumption that addition of cartilage forming cells to an area of localized damage will be sufficient to effect repair. The reviewers commended the applicant for including an early interaction with the FDA and viewed the early and continuing focus on regulatory concerns and FDA interactions as particular strengths of the proposal. However, the reviewers had multiple concerns that led them to doubt an IND could be achieved in four years. They commented that the preclinical data are limited and the project seemed to be still early and undefined. For instance, the final product has yet to be established and the plan to compare the effects of various hydrogel/scaffold combinations is interesting but does not lend itself well to product development. Also, because the applicant has not yet demonstrated disease-modifying proof-of-concept activity, the data appear not to be sufficiently mature for a development project. It was felt that the manufacturing goals are overly ambitious and would be subject to delay. For example, sourcing juvenile knee cartilage may be more difficult than anticipated, due to limited availability and competition for this resource. From a regulatory standpoint, the use of an allogeneic/autologous two-cell system raises concerns about cell-cell interactions which the proposal did not address. One reviewer expressed doubts that the FDA would allow this to go forward. Another reviewer expressed concern regarding the proposal's approach to immune rejection and questioned the applicant's conclusion regarding the likelihood of immune tolerance in this system. This reviewer commented that there was no detailed analysis of the degree of Major Histocompatibility Complex (MHC) mismatching, which would influence the extent of any immune response. Since patients with focal cartilage defects do not have a life threatening end-stage disease, the risk of lifelong immunosuppression would likely not be tolerated in this population. Therefore this is a key issue for this clinical target. Collectively, the multidisciplinary research team represents an appropriate mix of basic and clinical research together with management skills to ensure progress of the project, and the Collaborative Funding Partner adds significant value. The PI has the necessary experience to manage a project of this magnitude and scope and clearly understands the importance of effective technology transfer of documented methods and has allowed appropriate time for these processes. The leadership plan appears well conceived and should ensure coordinated activities across the team to enable effective monitoring of progress against milestones, implement strategic decisions and resolve potential conflicts. In general the budget seems appropriate. The budget, however, reflects continuing expenditure. Reviewers also questioned the justification for a confocal microscope since results from confocal imaging analyses are not cited as one of the product evaluation criteria. In summary, reviewers commented that the proposed indication is an excellent context to test the hypothesis that the addition of cartilage-forming cells will be sufficient to effect repair and that the addition of a matrix to provide structural stability is an added potential benefit. However, they were unconvinced regarding the scientific rationale for the proposed two-cell system and overall, the complexity of the proposed therapeutic product was a major concern with respect to manufacturing and clinical logistics as well as the regulatory path. There was agreement that this proposal seemed premature and unlikely to achieve the objective of filing an IND within four years.


text:
Loew's State Theatre
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Showing 76 - 100 of 582 comments
I found it interesting that the marquee wasn't going to have traditional changeable letters but would get a new special for each attraction. I remember when it was a twin, each side of the marquee had its own custom display but eventually they played movies for which they wouldn't or couldn't make a special display and it was back to the red letters on a white background.
I was delighted to read this article; although I was sure that the seat upholstery fabric was primarily gold colored. This was a half-century ago, so I could well be wrong. I am sure that, when I complete and post my recollection of the first-run experience of "Ben Hur" at Loews State, someone is going to dispute some of the details which I recall. Such is life, and the limitations of human memory.
Here is a more thorough article in Boxoffice.
Saps, I either never copied it or lost the remainder of that article.
Al where's page 17? (And I love the no-nonsense delivery of the old Variety!)
David, here is a snipet from Variety regarding the re-opening for "SOME LIKE IT HOT" earlier that year.
I don't have the whole article but it might give you some ideas.
In a few days, I will definitely put together an account of the Loews State "Ben Hur' first-run experience. I wish I could find reliable info about that enormous refurbishing that they did on the theater for this premiere run. I had not seen the interior of the theater before I saw this film there, but I understand that they made major changes. – Dave Greene
David, have you considered posting your account on the Happy 50th, Ben-Hur page?
In browsing the community guidelines link below, I don't see anything about limitations to the size of a post as long as it's relevant to the theater…and what you propose is EXACTLY what people value reading here. Please post it. If by some chance you do run up against some limit on size, just continue in another post.
David, you could either post it here in its entirety, or type it up and send as an attachment to anyone who requests it.
I tried to set down a reasonably brief description of the first-run experience of "Ben Hur" at Loew's State. There were just too many details that I deem to be essential to communicating the magic of that experience. I felt that the amount of text this description would require would be so great as to almost certainly violate some rule governing how much you could post in any one comment. I am nevertheless determined to set it all down in writing. The whole thing was just too unique in all my years of moviegoing, and I am still thrilled by the memory. If anyone knows a way that I might pass along the completed account to anyone that might be interested, I would be only too pleased to share the thing. I'll monitor this site for suggestions.
Status needs to be changed to "Demolished."
I second the motion. Please do it, David. I'm seeing the 8K digital presentation of Ben-Hur at the New York Film Festival this Saturday in Alice Tully Hall, but I'm going to pretend it's 1959 and I'm at the Loew's State.
Please do it!
I positively "haunted" this theater during the first-run engagement of "Ben Hur". The remodeling of the theater for that show, together with the brilliant customization of their presentation of the film absolutely enchanted me at age 14. William Wyler's renowned meticulous attention to details seemed to have been carried over to the way this theater handled the screening. This is a lost art. I have long considered writing a detailed account of the experience they provided as the modern Cineplex has made so much of that sort of finesse extinct.
Just uploaded a scan of the little foldout program (not the deluxe souvenir book) handed out on the night of the world premiere and presumably during the roadshow engagement of "Ben-Hur".
I'd love to learn anything that anyone could tell us about the "Ben-Hur Bar and Cocktail Lounge", such as what the setup actually consisted of, and whether it operated throughout the long roadshow engagement or just for a limited time.
And of course pictures would be most welcome!
Abe Balaban from the company of Balaban & Katz was asked what he thought movie theaters would be like in the future. He said I believe there will be huge screens and thousands of seats and all the theaters would be connected to a main giant concession booth. And this was during the time they were building their palaces in Chicago! Of course no one could imagine the impact of television on the industry!
I would doubt it very much – inasmuch as he died in 1927 during the heyday of the building of the grand movie palaces when many of his theaters still had vaudeville and stage shows. As most CT readers know, he very famously remarked that Loew's "[sold] tickets to theaters – not movies." I think he would have been appalled at some of theaters that later bore his name.
I wondered if he ever imagined what the cinema would become in 2011 or for that matter 1970 which became the dawn of the shoebox mulitplex!
141 Years today Marcus Loew was born.
Sixty-two years ago today, MGM's "The Barkleys of Broadway," reuniting Fred Astaire and Ginger Rogers in what was also their first musical in color (by Technicolor), opened its world premiere engagement at Loew's State. Thrown in as a bonus were two recent Academy Award-winning Technicolor shorts, Walt Disney's live-action "Seal Island" and MGM's Tom & Jerry cartoon "The Little Orphan."
Thanks for the link Tinseltoes. I remember the incident but forgot the details. I remember the courtroom scene with Lana who was playing "Lana" as if in one of her films.
Fifty-three years ago today, Paramount's eagerly-awaited "Another Time, Another Place," Lana Turner's first movie to be released since her implication in one of Hollywood's most sensational murder cases, opened its NYC premiere engagement at Loew's State. Filmed on location in England in B&W VistaVision, the romantic melodrama had no relevance to Turner's private turmoil, but advertising copy suggested it: "The story of a woman possessed by love and fear…yielding to emotions no woman in love can resist." For those too young to remember, here's one interpretation of what really happened:
Of course I meant "grand" by todays standards. Many of the movie palaces were also made of fake marble and imitation materials that looked real. I give Muvico A+ for trying to give future customers what it was like to attend a Loew's State, Paramount, Fox or a RKO and many other names that graced our landscape from coast to coast. Someone in that company loves the glory of the movie palaces and I think they should be commended for doing so.
I suppose "grand" is – like beauty – very much in the eyes of the beholder; much as I like the Muvico Rosemont (and most of the other Muvico theaters),it is still a false, Disneyesque sort of grand. There is no or little real marble, crystal, brass or ornate plaster, but simulations using far cheaper materials – plastics, fiberglass, sheetrock, not even real scagliola, but I will take it over those bland boxes of movie theaters that were the rage for so many decades.


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The Arkansas baseball team is set for another rematch with LSU Saturday at the SEC Tournament on ESPNEWS.
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17 Egyptians Injured in Election-Related Violence
Seventeen people were injured Saturday, six of them seriously, when Egyptian police and supporters of an independent candidate for the consultative council elections clashed in the Gharbiya, around 100 kilometers north of the capital Cairo, reported the daily Al Ahram.
The incident occurred when supporters of the independent candidate Mohammad Sukkar threw stones at police blocking access to polling stations, said the paper.
The police dispersed them with tear gas grenades, after some of Sukkar's supporters set three vehicles on fire and attempted to block the railway line linking Gharbiya to Cairo.
Among the injured were two policemen.
Forty-three candidates ran in Saturday's run-off mid-term elections in five governorates: Gharbiya, Demyat, Sharqeyyah, South Sinai and Duqhelya.
The 264-seat Shura Council is a consultative body that serves as an upper house.
According to the constitution, there should be no less than 132 members, two thirds of them elected by secret ballot, while the remaining third is appointed by the president.
The council provides consultations on constitutional and other major issues - Albawaba.com
© 2001 Al Bawaba (www.albawaba.com)
Top Headlines
- Egypt's Ruling Party Scores Another Victory in Shura Elections
- NDP Wins 14 of 19 Seats in Egypt's First-Stage Shura Council Elections
- First Stage of Egyptian Shura Elections Held Amid Calm
- Egypt's Shura Council Elections Kick Off Wednesday
- Egypt's Muslim Brotherhood Says Government Seeks to Block its Participation in Shura Elections


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Considering the recent conversation regarding whether or not Saturday Night Live player Kenan Thompson is correct in his assertion that women-of-color are absent from that show's cast due to their unreadiness in auditions, I thought I'd revisit a post from last year that highlighted the talents of several funny women-of-color who are indeed ready for primetime.
I think it's time for funny women like Claudia M. Wallace, Leslie "Big Les" Jones, and Anjelah Johnson to get a shot at making us laugh on a grander stage like SNL's.
Claudia M. Wallace
She's an alum of the famed Second City comedy troupe who has had small roles in films and TV shows such as Nothing Like The Holidays and Hung.
Leslie "Big Les" Jones
She's a veteran stand-up comic who has appeared in films such as Russ Parr's Something Like A Business, and whose debut stand-up DVD, Problem Child, will have you rolling.
Anjelah Johnson
This Latina-- a former NFL cheerleader-- had a brief, but memorable, run on FOX's MADtv, and has produced a hilarious stand-up DVD titled That's How We Do It!
Parker664 | January 9, 2014 6:43 AM
Good call on Leslie Jones being a good fit at SNL. Hopefully she'll get some time in front of the camera, too. Anjelah Johnson would be great, too, but I guess no MADtv alums allowed.
YesMa'am | October 21, 2013 6:22 PM
Youtube "Sharaé Nikai Acting Reel". Another Afr-Amer female comedic actress on the rise.
Sleepyhead4life | October 21, 2013 11:36 AM
How did this get turned into a "women of color" conversation? Kenan specifically bashed black women and threw them under the bus, not "women of color". And the black women featured are way too seasoned to be on SNL anyway. If this specific racio-misogyny is going to be used as a template, then at least give black women the respect to not conflate this into including non-black women in the conversation. Ms. Wilson gave a very nuanced interview where she eliminated herself from consideration to working on SNL and stated if Lorne Michaels was having a problem with the women auditioning that was a separate issue from any claims that there weren't any funny and qualified black women potential cast members.
Sharon Ball | October 18, 2013 7:54 PM
These ladies are the funniest comedienne's I've heard in a longtime. As for the SNL comment regarding lack of women of color representation, truth is SNL lacks funny comedians period, male or female, black, brown, or white. SNL hasn't been funny in a very long time. I'ts like one of those old bars in your neighbor that use to pack them in back in the day, you'd miss it if were gone but you don't plan on ever going while it's still open.
Shak | October 17, 2013 7:50 PM
Ever since I saw Skye Townsend's Beyonce video I thought, if given the chance, she could breath some new life into SNL.
Bforreal | October 16, 2013 11:49 PM
Debra Wilson. She convinced me that MadTV was always the better show. She could run circles around many of the SNL cast. End of story.
Akimbo | October 16, 2013 2:23 PM
WTF is y'all doing? You repurpose an old article and import the old comments, rendering many of them off-topic? That's really, really weird.
Aaantyways, Angela Yarbrough, Robin Thede, and Nikea Gamby-Turner (in that order) of sketch troupe Elite Delta Force 3 are ready and MadTV alumna Danielle Gaither (of the Groundlings' The Black Version) and Nicole Randall Johnson would light that shit up.
Ashley | October 16, 2013 11:20 AM
I LOVE Big Les!! She is so funny! I still think Debra Wilson is one of the best sketch artists around.
CalArtian citizen | October 16, 2013 10:49 AM
Not to mention Bresha Webb killing it on Love That Girl!
She's also a CalArts alum.
CalArtian Citizen | October 16, 2013 10:47 AM
Brilliant writer of her one woman show 'The Morning Aftershow" that premiered in LA last year.
She's Kanye West, RuPaul and Sandra Bernhard mashed together. Also was a cast member on the new In Living Color. Check into her!
bohemian princess | October 16, 2013 9:48 AM
I was about to throw Gina Yashere's hat in the ring but I noticed someone already did from last year. She's not American but I personally think she's funnier than all these women and doesn't necessarily go for the low hanging fruit when it comes to jokes.
Wyatt | March 13, 2012 3:48 PM
Claudia Wallace is hilarious. LMAO!@!! Big Bad Love should be a series for sure! She cracks me up
Lisa | March 13, 2012 1:29 PM
Not enough people know about Leslie Jones! She. Is. Incredible!
anon | March 11, 2012 4:57 PM
god is this what aa women call comedy it was distasteful. Gina yashere -a brit is really good, funny and NOT sterotypical apparently shes doing well over here.
Monique A. Williams | March 10, 2012 10:27 AM
These play on stereotypes, so I'm not so hung ho about them getting their own vehicles. That Second City clip tho had me laughing out loud.
And Bon Qui Qui's music video is no less ridiculous than the music out right now. Fits right into the landscape.
Shaahn | March 9, 2012 5:49 PM
I love anjelah Johnson. I never saw this video. Too cute
BluTopaz | March 8, 2012 11:33 PM
Bon Qui Qui is hilarious.
Akelah | March 8, 2012 3:45 PM
I would like to see a black comedienne in her own show not depending on played out stereotypes to be appealing to the mainstream..the last actress (with her own show) I can think of who did goofy, funny character work well was Raven-Symone.
Cherish | March 8, 2012 1:53 PM
Trying to decide if I was insulted by BIG BAD LOVE. What the hell - that sh*t was funny LOL.
Good luck to ladies here.
Miles Ellison | March 7, 2012 9:41 PM
I don't think Leslie Jones is all that funny, but she's a comic genius compared to Whitney Cummings and Chelsea Handler. They're hot garbage.
Akimbo | March 7, 2012 7:23 PM
The studio behind Mindy Kaling's untitled comedy pilot is Universal, as in NBC Universal. Just because the show would air on Fox doesn't mean her parent company has completely abandoned her. I like Michelle Wallace, but am not as big on the other two comediennes. I would actually love to see Retta (of Parks & Rec) and writer/performer Angela Yarbrough (of Elite Delta Force 3, The Message, & co-writer of that Wayne Brady/Crispus Attucks vid) in their own vehicles; I love their senses of humor.
Tamara | March 7, 2012 4:35 PM
I'm not too shocked by NBC. They seem to be both diverse but not at the same time. I don't get the "Whitney" show. "Community" has to go the way of the samurai while "Whitney" lives on. Even the "Out Sourced" show didn't survive and that played to the multi-cultural/colorfulness that NBC has been pretty good with displaying in their series. But then again that show all around sucked and I digress. There are plenty African-American/Black comediennes that I would love to see have their own show; heck, their own stand-up shows (where you at Comedy Central?), but it's not happening for whatever reason. I yearn for the days of "Living Single", "Half & Half", "Girlfriends". There was an obvious audience for those shows and those women represented dramatically and comedically quite well. Thanks for the post. I'll have to review some of these clips later.
Steven | March 7, 2012 1:23 PM
Good article Emmanuel. I always wonder what other comedic actresses of color are out there. I'm somewhat shocked that NBC didn't at least greenlight a pilot with Mindy Kaling.


text: St. Aug's Division of Liberal Arts and Education hosted a Black History program on February 23 in the auditorium of Seby Jones. The program consisted of a multi-media skit, "Freedom's Legacy," a panel discussion and a question and answer session.The Freedom's Legacy skit was performed on the premise of an elderly man teaching his granddaughter about the plight for equality amongst African-Americans. During the skit, the elderly man played by Dante Sellers, senior in Film and Theater, covered not only the Civil Rights movement but also slavery and Egyptians. "This play helped the audience understand the various figures that fought for our freedom," stated Sellers. "We have to continue working to gain freedom because freedom is not guaranteed, it's all up to us." Pictured: Keaven Russell, junior, seen here portraying an Egyptian pharaoh.


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TAUNTON (FOX 25 / MyFoxBoston.com) – Between 50 and 60 people may have been displaced after a fire in Taunton.The fire sent dozens of people out into the cold Sunday night. The blaze started around 9 p.m. in the attic of the apartment building, which has three floors, eight units on each floor.A viewer sent FOX 25 incredible video of the fire, which showed flames shooting from the Chateau Condos at 103 Hart St.Two firefighters suffered minor injuries.
Meanwhile, American Red Cross volunteers have provided emergency temporary shelter, a hotel stay, for 18 residents displaced by the fire. Volunteers have provided emergency funds for food and clothing to 30 residents thus far, and have opened a warming center at the Silver City Galleria. There, they will further assess needs of residents.
The cause of the fire remains under investigation.
25 FOX DriveDedham, MA 02026
Phone (781) 467-2525


text:
The Meadowbrook School in Abington will hold its annual Winter Arts Festival, a family-friendly arts event, on Saturday, Jan. 25 and Sunday, Jan. 26 at the elementary school.
The event, which is open to the public, will feature more than 1,000 pieces of art by Meadowbrook students from preschool through sixth grade. The artwork will be on display in both the Shuttleworth Gym and the Goldsmith Greenfield Art Gallery.
Meadowbrook art teacher Jillian Katona organized the exhibit, which will include an array of artwork in several media.
Katona, who has taught art for more than 20 years, said, "Our Meadowbrook Winter Arts Festival is designed to be kid-friendly. It is the perfect venue for families who want to expose their young children to the arts, as well as inspire their imaginations and inner creativity."
A special exhibit featuring the work of renowned oil painter Alan Fetterman, will also be on display. Fetterman is a Bucks County painter and will be a guest speaker at the school in spring.
The Winter Arts Festival will be open today from 1 to 4 p.m. and Sunday, from 1 to 3 p.m.
The Meadowbrook School is located at 1641 Hampton Road, Meadowbrook.


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Phin's Fleet by QoA Running Club - 10 months ago
"Today 36 students, ages 3 to 10, ran 1 or 2 miles in memory of 6th grade student Phin Jensen who passed away a few weeks ago. Before Phin was sick he loved to run. After training for 6 weeks this fall and with the guidance of Coach Tina and Coach Peggy, now there are 36 children who love to run too."


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There are many different types of learning opportunities, sessions and seminars at Mobile World Congress. We know it can be confusing, so here's a list of the available options so you can better understand our terminology, plan your time at Congress, and determine which pass type is best for you:
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Our Conference programme is a key component of Congress, featuring executives from leading companies in the mobile space and experts from adjacent industries which are Creating What's Next. Sessions are composed of presentations, panel discussions and audience questions.
The only way to view conference sessions is to hold a Platinum, Gold or Silver Pass. Pass holders also receive access to presentation materials after the event. Video excerpts may be shown later on MobileWorldLive.com, but for maximum impact, you will want to be present for the entire session.
Note: All Conference sessions and Keynotes will take place in Hall 4, in the centre of Fira Gran Via. Please note that access into Hall 4 is restricted to Platinum, Gold or Silver Pass holders.
Our morning Keynote sessions are part of the conference programme (see above) and therefore require a Platinum, Gold or Silver Pass for entry.
Mobile World Live Keynotes
Keynotes advertised as 'Mobile World Live Keynotes' are streamed live on www.MobileWorldLive.com and may be viewed by anyone with a computer or mobile device. We will offer viewing areas throughout Fira Gran Via where these can be viewed by Exhibition Visitor Pass holders, but only the Platinum, Gold and Silver Pass holders are allowed in the auditoria and relay rooms.
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App Developer Conferences (ADCs) are sessions specifically for the app community. Led and managed by our App Planet Supporting Sponsors, these featured programmes allow developers and members of the mobile app community to meet platform and device manufacturers, receive insights and help in marketing apps, and network with other developers.
App Developer Conferences are open to all pass holders, however attendees must pre-register their interest in attending ADCs. The Supporting Sponsor hosting the ADC will contact attendees directly to confirm attendance at their event. Please note attendees are welcome to attend multiple ADCs, even concurrent ADCs.
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