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Summary: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
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Publications279 found, 100 shown here
- Anti-prostate-specific membrane antigen-based radioimmunotherapy for prostate cancerScott T Tagawa
Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA
Cancer 116:1075-83. 2010..Future studies will include approaches to optimize patient selection and incorporate novel strategies to improve the success of anti-PSMA radioimmunotherapy.
- Toxicity and efficacy of combined radioimmunotherapy and bevacizumab in a mouse model of medullary thyroid carcinomaPierre Yves Salaun
Nuclear Oncology Department, Cancer Research Center, INSERM U892, Universite de Nantes, Nantes, France
Cancer 116:1053-8. 2010Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice...
- 131I-tositumomab therapy as initial treatment for follicular lymphomaMark S Kaminski
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 0936, USA
N Engl J Med 352:441-9. 2005Advanced-stage follicular B-cell lymphoma is considered incurable. Anti-CD20 radioimmunotherapy is effective in patients who have had a relapse after chemotherapy or who have refractory follicular lymphoma, but it has not been tested in ..
- Cancer radioimmunotherapyRobert M Sharkey
Garden State Cancer Center, Belleville, NJ 07109, USA
Immunotherapy 3:349-70. 2011Targeting of radionuclides with antibodies, or radioimmunotherapy, has been an active field of research spanning nearly 50 years, evolving with advancing technologies in molecular biology and chemistry, and with many important preclinical ..
- Comparative toxicity and efficacy of combined radioimmunotherapy and antiangiogenic therapy in carcinoembryonic antigen-expressing medullary thyroid cancer xenograftFrançoise Kraeber-Bodéré
INSERM UMR 892 Cancer Research Center, Universite de Nantes, Nantes, France
J Nucl Med 51:624-31. 2010A significant antitumor effect was previously observed with radioimmunotherapy using anti-carcinoembryonic antigen (131)I-F6 monoclonal antibody in medullary thyroid cancer-bearing nude mice...
- Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude miceBirgit Pfost
Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
J Nucl Med 50:1700-8. 2009....
- Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I studyHakan Andersson
Department of Oncology, University of Gothenburg, Gothenburg, Sweden
J Nucl Med 50:1153-60. 2009..The aim was to determine the pharmacokinetics for assessing absorbed dose to normal tissues and investigating toxicity...
- Dosimetric analysis of 177Lu-cG250 radioimmunotherapy in renal cell carcinoma patients: correlation with myelotoxicity and pretherapeutic absorbed dose predictions based on 111In-cG250 imagingAlexander B Stillebroer
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Nucl Med 53:82-9. 2012This study aimed to estimate the radiation absorbed doses to normal tissues and tumor lesions during radioimmunotherapy with (177)Lu-cG250...
- Absolute lymphocyte count predicts therapeutic efficacy and survival at the time of radioimmunotherapy in patients with relapsed follicular lymphomasL F Porrata
Leukemia 21:2554-6. 2007
- Pretargeted 177Lu radioimmunotherapy of carcinoembryonic antigen-expressing human colonic tumors in miceRafke Schoffelen
Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Nucl Med 51:1780-7. 2010Pretargeted radioimmunotherapy (PRIT) with bispecific antibodies in combination with a radiolabeled peptide reduces the radiation dose to normal tissues, especially the bone marrow...
- High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: results of a multicenter, phase I/II study in non-Hodgkin's lymphomaFranck Morschhauser
Service des Maladies du Sang, Centre Hospitalier Regional, L Universitaire de Lille, France
J Clin Oncol 28:3709-16. 2010Fractionated radioimmunotherapy targeting CD22 may substantially improve responses and outcome in non-Hodgkin's lymphoma (NHL).
- Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasisKarin Knogler
Center for Radiopharmaceutical Science, ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
Clin Cancer Res 13:603-11. 2007..We examined the tumor-targeting and therapeutic effects of (67)Cu-labeled single amino acid mutant forms of anti-L1 monoclonal antibody chCE7 in nude mice with orthotopically implanted SKOV3ip human ovarian carcinoma cells...
- Update of carcinoembryonic antigen radioimmunotherapy with (131)I-labetuzumab after salvage resection of colorectal liver metastases: comparison of outcome to a contemporaneous control groupTorsten Liersch
Department of General Surgery, University of Gottingen, Gottingen, Germany
Ann Surg Oncol 14:2577-90. 2007We tested whether adjuvant radioimmunotherapy (RAIT) given after R0 resection of liver metastases (LM) of colorectal cancer is safe and can improve survival...
- Radioimmunotherapy of B-cell lymphoma with radiolabelled anti-CD20 monoclonal antibodiesR O Dillman
Medical and Scientific Director, Hoag Cancer Center, Newport Beach, CA 92658, USA
Clin Exp Med 6:1-12. 2006..Clinical trials suggest that anti- CD20 radioimmunotherapy is superior to total body irradiation in patients undergoing stem cell supported therapy for B-cell lymphoma,..
- Radioimmunotherapy of relapsed indolent non-Hodgkin lymphoma with 131I-rituximab in routine clinical practice: 10-year single-institution experience of 142 consecutive patientsMichael F Leahy
Department of Hematology, The University of Western Australia, Fremantle Hospital, Fremantle, Australia
Blood 117:45-52. 2011b>Radioimmunotherapy of indolent non-Hodgkin lymphoma (NHL) has achieved objective response rates in clinical trials comparable with standard rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy, but is ..
- Radioimmunotherapy and colorectal cancerM J Koppe
Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Br J Surg 92:264-76. 2005Despite the success of radioimmunotherapy (RIT) using radiolabelled monoclonal antibodies (Mabs) directed against tumour-associated antigens in the treatment of non-Hodgkin's lymphoma, therapeutic success in solid tumours has been modest...
- Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experienceM S Kaminski
Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0936, USA
Blood 96:1259-66. 2000CD20-targeted radioimmunotherapy is a promising new treatment for B-cell non-Hodgkin lymphoma (NHL)...
- Positron emission tomography (PET), immuno-PET and radioimmunotherapy in renal cell carcinoma: a developing diagnostic and therapeutic relationshipNathan Lawrentschuk
Department of Surgery, University of Melbourne, Australia
BJU Int 97:916-22. 2006
- Prospective trial of targeted radioimmunotherapy with Y-90 ibritumomab tiuxetan (Zevalin) for front-line treatment of early-stage extranodal indolent ocular adnexal lymphomaB Esmaeli
Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Oncol 20:709-14. 2009..To determine the efficacy and side-effects of (90)Y ibritumomab tiuxetan (Zevalin) as front-line treatment in patients with early-stage extranodal indolent lymphoma of the ocular adnexa (orbit, conjunctiva, or eyelid)...
- The clinical importance of dosimetry in radioimmunotherapy with tositumomab and iodine I 131 tositumomabRichard L Wahl
Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Department of Radiology, Baltimore, MD 21287 0817, USA
Semin Oncol 30:31-8. 2003b>Radioimmunotherapy (RIT) is a promising emerging therapy for non-Hodgkin's lymphoma and may ultimately prove useful in the treatment of other tumors...
- Clinical radioimmunotherapy--the role of radiobiologyJean Pierre Pouget
Direction de la RadioProtection de l Homme, Institut de Radioprotection et de Surete Nucleaire, Fontenay aux Roses, F 92262, France
Nat Rev Clin Oncol 8:720-34. 2011Conventional external-beam radiation therapy is dedicated to the treatment of localized disease, whereas radioimmunotherapy represents an innovative tool for the treatment of local or diffuse tumors...
- PET/CT Imaging and Radioimmunotherapy of Prostate CancerKirsten Bouchelouche
PET and Cyclotron Unit, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
Semin Nucl Med 41:29-44. 2011..Prostate cancer represents an attractive target for radioimmunotherapy (RIT) for several reasons, including pattern of metastatic spread (lymph nodes and bone marrow, sites with ..
- Intratumoral distribution of two consecutive injections of chimeric antibody G250 in primary renal cell carcinoma: implications for fractionated dose radioimmunotherapyM G Steffens
Department of Urology, University Hospital Nijmegen, The Netherlands
Cancer Res 59:1615-9. 1999..the intratumoral distribution of the antibody is highly heterogeneous, which may limit the efficacy of radioimmunotherapy. A number of highly dynamic physiological factors have been postulated that may contribute to heterogeneous ..
- Pretargeted radioimmunotherapy of colorectal cancer metastases: models and pharmacokinetics predict influence of the physical and radiochemical properties of the radionuclideEric Frampas
Centre de Recherche en Cancérologie Nantes Angers, Universite de Nantes, INSERM, UMR 892, 8 quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France
Eur J Nucl Med Mol Imaging 38:2153-64. 2011We investigated influences of pretargeting variables, tumor location, and radionuclides in pretargeted radioimmunotherapy (PRIT) as well as estimated tumor absorbed doses.
- Adjuvant radioimmunotherapy improves survival of rats after resection of colorectal liver metastasesGabie M De Jong
Division of Abdominal and Oncological Surgery, Department of Surgery, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, Nijmegen, The Netherlands
Ann Surg 253:336-41. 2011The aim of this study was to test the hypothesis that adjuvant radioimmunotherapy (RIT) prevents recurrent liver metastases and/or results in improved survival after tumorectomy in an experimental model.
- Sensitivity and prognostic value of positron emission tomography with F-18-fluorodeoxyglucose and sensitivity of immunoscintigraphy in patients with medullary thyroid carcinoma treated with anticarcinoembryonic antigen-targeted radioimmunotherapyAurore Oudoux
Nuclear Medicine, University Hospital, 44093 Nantes, France
J Clin Endocrinol Metab 92:4590-7. 2007..Patients with progressive medullary thyroid carcinoma (MTC) undergo multiple imaging procedures for diagnosis of relapse and staging...
- Pretargeted radioimmunotherapy of cancer: progress step by stepOtto C Boerman
Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Nucl Med 44:400-11. 2003To enhance the therapeutic efficacy of radioimmunotherapy of cancer, several pretargeting strategies have been developed...
- Recombinant bispecific monoclonal antibodies prepared by the dock-and-lock strategy for pretargeted radioimmunotherapyRobert M Sharkey
Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ, USA
Semin Nucl Med 40:190-203. 2010..However, for many other cancers, radioimmunotherapy has been ineffective, being limited by prolonged exposure to the highly radiosensitive bone marrow...
- Radioimmunotherapy improves survival of rats with microscopic liver metastases of colorectal originGabie M De Jong
Department of Surgery, Division of Abdominal and Oncological Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Surg Oncol 16:2065-73. 2009..The aim of the present study was to assess the efficacy of radioimmunotherapy (RIT) with a radiolabeled monoclonal antibody (mAb) to treat experimental colorectal liver metastases.
- High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer modelT M Behr
Department of Nuclear Medicine, Georg August University, Gottingen, Germany
Cancer Res 59:2635-43. 1999Recent studies suggest that radioimmunotherapy (RIT) with high-linear energy transfer (LET) radiation may have therapeutic advantages over conventional low-LET (e.g., beta-) emissions...
- Using anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancerJing Chen
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No 1095, Jiefang Dadao, 430030 Wuhan, People s Republic of China
Cancer Lett 231:169-75. 2006..The results suggests that the radioimmunotherapy of intratumoral injection of 131I-Sc-7269-DMN may be safe and efficient for the treatment of liver cancer...
- Phase I/II 90Y-Zevalin (yttrium-90 ibritumomab tiuxetan, IDEC-Y2B8) radioimmunotherapy dosimetry results in relapsed or refractory non-Hodgkin's lymphomaG A Wiseman
Department of Radiology, Nuclear Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
Eur J Nucl Med 27:766-77. 2000..The only toxicity of note is hematologic and is not correlated to red marrow radiation absorbed dose estimates or T(1/2), reflecting that hematologic toxicity is dependent on bone marrow reserve in this heavily pretreated population...
- A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphomaAuayporn Nademanee
Division of Hematology and Hemapoietic Cell Transplantation, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA
Blood 106:2896-902. 2005..We conclude that high-dose 90Y-ibritumomab tiuxetan can be combined safely with high-dose etoposide and cyclophosphamide without an increase in transplant-related toxicity or delayed engraftment...
- Phase 1/2 study of fractionated (131)I-rituximab in low-grade B-cell lymphoma: the effect of prior rituximab dosing and tumor burden on subsequent radioimmunotherapyTim M Illidge
School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
Blood 113:1412-21. 2009..of induction therapy with multiple doses of rituximab on the subsequent efficacy and toxicity of anti-CD20 radioimmunotherapy is unknown...
- 131I-Anti CD20 radioimmunotherapy of relapsed or refractory non-Hodgkins lymphoma: a phase II clinical trial of a nonmyeloablative dose regimen of chimeric rituximab radiolabeled in a hospitalJ Harvey Turner
Department of Nuclear Medicine, Fremantle Hospital and Department of Medicine, The University of Western Australia, Fremantle, Western Australia, Australia
Cancer Biother Radiopharm 18:513-24. 2003In order to increase the availability and affordability of radioimmunotherapy of refractory or relapsed non-Hodgkins lymphoma, we developed and evaluated radioiodinated rituximab in an ongoing physician-sponsored Phase II Clinical Trial...
- Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: a multiinstitutional comparisonBarry W Wessels
Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio
J Nucl Med 45:1725-33. 2004..In this work, we have analyzed reported marrow dosimetry results from radioimmunotherapy trials and recalculated marrow absorbed doses at a central facility using a standard blood model with ..
- Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patientsStefanie Sauer
Department of Pathology, Campus Benjamin Franklin, Charite Universitatsmedizin, Berlin, Germany
Blood 113:2265-74. 2009..In 2 relapsed Hodgkin lymphoma patients(131)I-L19SIP radioimmunotherapy induced a sustained partial response, qualifying ED-B FN as a promising target for antibody-based lymphoma ..
- Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and myelotoxicityJörgen Elgqvist
Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, SE 413 45 Goteborg, Sweden
Nucl Med Biol 33:1065-72. 2006The aim of this study was to investigate the therapeutic efficacy and myelotoxicity during fractionated radioimmunotherapy of ovarian cancer in mice...
- Radioimmunotherapy of lymphoma: Bexxar and ZevalinStanley J Goldsmith
Division of Nuclear Medicine, New York Presbyterian Hospital, Weill Cornell College of Medicine, New York, NY 10065, USA
Semin Nucl Med 40:122-35. 2010b>Radioimmunotherapy is a form of targeted radionuclide therapy that uses a monoclonal antibody to deliver localized radiation...
- A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomasTim Meyer
UCL Cancer Institute, University College London, United Kingdom
Clin Cancer Res 15:4484-92. 2009In preclinical models, radioimmunotherapy with (131)I-A5B7 anti-carcinoembryonic antigen (CEA) antibody ((131)I-A5B7) combined with the vascular disruptive agent combretastatin-A4-phosphate (CA4P) produced cures unlike either agent alone...
- Clinical development of radioimmunotherapy for B-cell non-Hodgkin's lymphomaRuby F Meredith
Department of Radiation Oncology, University of Alabama Medical Center, Birmingham, AL, USA
Int J Radiat Oncol Biol Phys 66:S15-22. 2006..Two radioimmunotherapy agents that target the CD20 antigen, (131)I-tositumomab and (90)Y-ibritumomab tiuxetan, have been approved ..
- Evaluation of response to fractionated radioimmunotherapy with 90Y-epratuzumab in non-Hodgkin's lymphoma by 18F-fluorodeoxyglucose positron emission tomographyCaroline Bodet-Milin
Nuclear Medicine Department, University Hospital, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France
Haematologica 93:390-7. 2008The study aimed to evaluate FDG-PET imaging for early prediction of response to radioimmunotherapy in patients with non-Hodgkin's lymphoma.
- Combination therapy with Pretarget CC49 radioimmunotherapy and gemcitabine prolongs tumor doubling time in a murine xenograft model of colon cancer more effectively than either monotherapyScott S Graves
NeoRx Corporation, Seattle, Washington 98119 4114, USA
Clin Cancer Res 9:3712-21. 2003Pretarget radioimmunotherapy (RIT) is a multistep strategy for cancer therapy designed to reduce nontarget organ exposure by uncoupling the tumor targeting moiety from the radioactive ligand...
- Perspectives of molecular imaging and radioimmunotherapy in lymphomaAndrei Iagaru
Department of Radiology, Division of Nuclear Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H 0101, Stanford, CA 94305 5427, USA
Radiol Clin North Am 46:243-52, viii. 2008..uses of 18F Fluoro-2-Deoxyglucose (18F FDG) PET and PET/CT for evaluation of lymphoma patients and use of radioimmunotherapy in lymphoma...
- Repeated radioimmunotherapy with 177Lu-DOTA-BR96 in a syngeneic rat colon carcinoma modelSophie E Eriksson
Department of Oncology, Lund University, Sweden
Cancer Biother Radiopharm 27:134-40. 2012Fractionation is generally used as a mean to improve radioimmunotherapy (RIT)...
- Phase II trial of anticarcinoembryonic antigen pretargeted radioimmunotherapy in progressive metastatic medullary thyroid carcinoma: biomarker response and survival improvementPierre Yves Salaun
Nuclear Medicine Department, University Hospital and ICO Gauducheau Cancer Institute, IRCNA, Cancer Research Center, Universite de Nantes, INSERM, UMR 892, Nantes, France
J Nucl Med 53:1185-92. 2012..This prospective phase II multicenter trial evaluated the efficacy and safety of anti-CEA pretargeted radioimmunotherapy (pRAIT) in rapidly progressing metastatic MTC patients and also how serum biomarker DTs correlate with ..
- Bismuth-213 radioimmunotherapy with C595 anti-MUC1 monoclonal antibody in an ovarian cancer ascites modelEmma Y Song
Centre for Experimental Radiation Oncology, Cancer Care Centre, St George Hospital, Kogarah, UK
Cancer Biol Ther 7:76-80. 2008..The aim of this study was to investigate the effect of targeted alpha therapy (TAT) for the control of ascites in an OC ascites mouse model; the biodistribution of (213)Bi-C595 and its long term toxicity...
- Radioimmunotherapy with 131I-rituximab: what we know and what we don't knowMalik E Juweid
Cancer Biother Radiopharm 18:489-95. 2003
- Outpatient 131I-rituximab radioimmunotherapy for non-Hodgkin lymphoma: a study in safetyPhillipe J Calais
Department of Nuclear Medicine, The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
Clin Nucl Med 37:732-7. 2012This study aimed to establish the safety of outpatient 131I-rituximab radioimmunotherapy by measuring the radiation exposure of hospital staff, carers, and members of the public and by estimating the environmental impact of radioactive ..
- Radioimmunotherapy: optimizing delivery to solid tumorsVineeth Rajkumar
UCL Cancer Institute, University College London, 72 Huntley St, London WCIE 6BT, UK
Ther Deliv 2:567-72. 2011b>Radioimmunotherapy (RIT) is a cancer treatment that exploits the specific targeting capability of monoclonal antibodies to deliver cytotoxic radionuclides to antigen-expressing tumor cells or stromal targets...
- (212)Pb@C(60) and its water-soluble derivatives: synthesis, stability, and suitability for radioimmunotherapyMichael D Diener
TDA Research Incorporated, 12345 West 52nd Avenue, Wheat Ridge, Colorado 80033 and Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831 6229, USA
J Am Chem Soc 129:5131-8. 2007Fullerenes could potentially play a valuable role in radioimmunotherapy by more stably encapsulating radionuclides, especially where conventional chelation chemistry is inadequate due to the physical and/or chemical properties of the ..
- Radioimmunotherapy in patients with head and neck squamous cell carcinoma: initial experienceD R Colnot
Department of Otolaryngology-Head and Neck Surgery, University Hospital Vrije Universiteit, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Head Neck 23:559-65. 2001..An effective adjuvant therapy is required for these patients. Among novel approaches is radioimmunotherapy, in which monoclonal antibodies (MAbs) are used for selective delivery of radiation to tumor cells...
- Role of biotin-binding affinity in streptavidin-based pretargeted radioimmunotherapy of lymphomaKevin J Hamblett
Department of Bioengineering, Medicine, University of Washington, Seattle, Washington 98195, USA
Bioconjug Chem 16:131-8. 2005One pretargeting approach to cancer radioimmunotherapy utilizes an antibody-streptavidin conjugate that is first localized to the tumor...
- Monoclonal antibodies for copper-64 PET dosimetry and radioimmunotherapyJeffrey N Bryan
Department of Veterinary Medicine and Surgery, University of Missouri Columbia, USA
Cancer Biol Ther 11:1001-7. 2011We previously described a two-antibody model of (64)Cu radioimmunotherapy to evaluate low-dose, solid-tumor response...
- Combining yttrium 90-labeled ibritumomab tiuxetan with high-dose chemotherapy and stem cell support in patients with relapsed non-Hodgkin's lymphomaJane N Winter
Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Clin Lymphoma 5:S22-6. 2004Targeted radioimmunotherapy, including yttrium 90-labeled ibritumomab tiuxetan (Zevalin) and iodine I 131 tositumomab (Bexxar), has the potential to increase the cure rate for patients with CD20+ B-cell malignancies who are undergoing ..
- Combining radioimmunotherapy and chemotherapy for treatment of medullary thyroid carcinoma: effectiveness of dacarbazineRhona Stein
Garden State Cancer Center, Belleville, New Jersey 07109, USA
Cancer 94:51-61. 2002..the efficacy of chemotherapy for medullary thyroid carcinoma (MTC), we evaluated the effect of combining radioimmunotherapy (RAIT) with 90Y-anticarcinoembryonic antigen (CEA) monoclonal antibody MN-14 and chemotherapy in nude mice ..
- Treatment recommendations for radioimmunotherapy in follicular lymphoma: a consensus conference reportThomas E Witzig
Mayo Clinic, Rochester, MN 55905, USA
Leuk Lymphoma 52:1188-99. 2011b>Radioimmunotherapy (RIT) with (90)Y-ibritumomab tiuxetan or (131)I-tositumomab combines a radiation-emitting radionuclide with an antibody targeting CD20 to treat B-cell non-Hodgkin lymphoma...
- Time dependence of the activity concentration ratio of red marrow to blood and implications for red marrow dosimetryCecilia Hindorf
Department of Radiation Physics, Lund University, Lund, Sweden
Cancer 94:1235-9. 2002The method for red marrow dosimetry in radioimmunotherapy, in the absence of specific activity uptake in red marrow, is based on the activity measured in the blood or plasma...
- Change in tumor-absorbed dose due to decrease in mass during fractionated radioimmunotherapy in lymphoma patientsCecilia Hindorf
Department of Medical Radiation Physics, Jubileum Institute, Lund University, SE 221 85 Lund, Sweden
Clin Cancer Res 9:4003S-6S. 2003..internal dosimetry protocols that assume a fixed tumor mass in lymphoma patients, using a fractionated radioimmunotherapy schedule and using a single infusion...
- Pre-therapy 18F-FDG PET quantitative parameters help in predicting the response to radioimmunotherapy in non-Hodgkin lymphomaThomas Cazaentre
Service de Médecine Nucléaire et Imagerie Fonctionnelle, CHU Lille, 59000, Lille, France
Eur J Nucl Med Mol Imaging 37:494-504. 2010b>Radioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging...
- Epidermal growth factor receptor-targeted radioimmunotherapy of human head and neck cancer xenografts using 90Y-labeled fully human antibody panitumumabZhaofei Liu
Medical Isotopes Research Center, Peking University, 38 Xueyuan Road, Beijing 100191, China
Mol Cancer Ther 9:2297-308. 2010..Here, we report for the first time the radioimmunotherapy (RIT) of EGFR-positive human head and neck cancer in a nude mouse model using pure beta(-) emitter (90)Y-..
- Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nucleiY Kvinnsland
Department of Nuclear Medicine, The Norwegian Radium Hospital, 0310, Norway
Radiat Res 155:288-96. 2001..The magnitudes of the differences were found to be a function of the fractions of mean specific energy delivered by surrounding activity and by activity bound to the cells...
- Follow-up results of a phase II study of ibritumomab tiuxetan radioimmunotherapy in patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma and mild thrombocytopeniaRussell Schilder
Fox Chase Comprehensive Cancer Center, Philadelphia, PA 1911 2412, USA
Cancer Biother Radiopharm 19:478-81. 2004..Patients received a single course of ibritumomab tiuxetan radioimmunotherapy, with 90Y ibritumomab tiuxetan administered at 0.3 mCi/kg (compared to a standard dose of 0.4 mCi/kg)...
- High-dose myeloablative radioimmunotherapy of mantle cell non-Hodgkin lymphoma with the iodine-131-labeled chimeric anti-CD20 antibody C2B8 and autologous stem cell support. Results of a pilot studyThomas M Behr
Department of Nuclear Medicine, Georg August University of Gottingen, Gottingen, Germany
Cancer 94:1363-72. 2002..been used successfully as a target molecule for conventional low-dose, as well as high-dose, myeloablative radioimmunotherapy (RIT) of B-cell non-Hodgkin lymphoma (NHL)...
- Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft modelJohn M Pagel
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Blood 118:703-11. 2011Pretargeted radioimmunotherapy (PRIT) using an anti-CD45 antibody (Ab)-streptavidin (SA) conjugate and DOTA-biotin labeled with β-emitting radionuclides has been explored as a strategy to decrease relapse and toxicity...
- Pretargeted radioimmunotherapy for B-cell lymphomasDamian J Green
Clinical Research Division, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
Clin Cancer Res 13:5598s-5603s. 2007..We have investigated the potential utility of pretargeted radioimmunotherapy using monoclonal antibody-streptavidin, immunoconjugates, and fusion proteins in combination with N-..
- Doubly radiolabeled liposomes for pretargeted radioimmunotherapyM Mougin-Degraef
Département de Recherche en Cancérologie, INSERM, U601, Universite de Nantes, 9 quai Moncousu 44093, Nantes Cedex 1, France
Int J Pharm 344:110-7. 2007The aim of this study was to design liposomes as radioactivity carriers for pretargeted radioimmunotherapy with favorable pharmacokinetic parameters...
- A genetically engineered anti-CD45 single-chain antibody-streptavidin fusion protein for pretargeted radioimmunotherapy of hematologic malignanciesYukang Lin
The Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cancer Res 66:3884-92. 2006..We now show the superiority of pretargeted radioimmunotherapy (PRIT) compared with conventional radioimmunotherapy using a recombinant tetravalent single-chain Ab-..
- Radioimmunotherapy of prostate cancer using 90Y- and 177Lu-labeled J591 monoclonal antibodies: effect of multiple treatments on myelotoxicityShankar Vallabhajosula
Department of Radiology, Division of Nuclear Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York 10021, USA
Clin Cancer Res 11:7195s-7200s. 2005Bone marrow is the dose-limiting organ in radioimmunotherapy. Fractionated dose regimens may decrease myelotoxicity and increase greater total administered dose...
- Editorial: what ails solid tumor radioimmunotherapy?Chaitanya Divgi
Cancer Biother Radiopharm 21:81-4. 2006
- Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotinZhengsheng Yao
Department of Nuclear Medicine, Warren G Magnuson Clinical Center, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 10:3137-46. 2004The use of an alpha emitter for radioimmunotherapy has potential advantages compared with beta emitters...
- Engineered single chain antibody fragments for radioimmunotherapyA Huhalov
Cancer Research UK Imaging and Targeting Group, Department of Oncology, Royal Free and University College Medical School, Royal Free Campus London, United Kingdom
Q J Nucl Med Mol Imaging 48:279-88. 2004An ideal molecule to deliver radioimmunotherapy (RIT) would be target specific and have prolonged residence time at high concentrations in the tumour with rapid clearance from normal tissues. It would also be non-immunogenic...
- Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infectionEkaterina Dadachova
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Infect Dis 193:1427-36. 2006The usefulness of radioimmunotherapy (RIT) for infectious diseases was recently demonstrated for several fungal and bacterial infections, but the mechanisms by which RIT is effective against microbes are uncertain.
- High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium-111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human Carol M Richman
University of California Davis, Sacramento, California 95817, USA
Clin Cancer Res 11:5920-7. 2005Although radioimmunotherapy alone is effective in lymphoma, its application to solid tumors will likely require a combined modality approach...
- Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopesEkaterina Dadachova
Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
J Nucl Med 45:313-20. 2004..One novel strategy is to use radioimmunotherapy (RIT) with fungal-binding monoclonal antibodies (mAbs) labeled with radionuclides...
- Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine modelsE Dadachova
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Antimicrob Agents Chemother 48:1004-6. 2004We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection...
- Feasibility of radioimmunotherapy of experimental pneumococcal infectionE Dadachova
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Antimicrob Agents Chemother 48:1624-9. 2004..We have recently established that radioimmunotherapy (RIT) can be used to treat experimental fungal infections in mice...
- Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trialsZhi Nan Chen
Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an, China
Int J Radiat Oncol Biol Phys 65:435-44. 2006..We developed iodine (131I) metuximab injection (Licartin), a novel 131I-labeled HAb18G/CD147-specific monoclonal antibody Fab'2 fragment, and evaluated its safety, pharmacokinetics, and clinical efficacy on HCC in Phase I/II trials...
- Combining radioimmunotherapy with antihypoxia therapy 2-deoxy-D-glucose results in reduction of therapeutic efficacyJason L J Dearling
Cancer Research UK Targeting and Imaging Group, Department of Oncology, Royal Free and University College Medical School, University College London, London, UK
Clin Cancer Res 13:1903-10. 2007The efficacy of solid tumor radioimmunotherapy is reduced by heterogeneous tumor distribution of the radionuclide, with dose mainly deposited in the normoxic region and by the relative radioresistance of hypoxic tumor cells...
- The radiation biology of radioimmunotherapyK L Dixon
Department of Physics, The University of British Colombia, Canada
Nucl Med Commun 24:951-7. 2003The treatment of cancer is a wide and varied field, encompassing many methods and modalities. Radioimmunotherapy is a technique which utilizes the ablative properties of radiation by delivering radioactive particles directly to the tumour ..
- Radioimmunotherapy with (111)In/(90)Y-2IT-BAD-m170 for metastatic prostate cancerR T O'Donnell
Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis Medical Center, Sacramento, California 95816
Clin Cancer Res 7:1561-8. 2001..b>Radioimmunotherapy (RIT) uses a tumor-specific monoclonal antibody to deliver systemic, targeted radiation to cancer...
- Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infectionRuth A Bryan
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Infect Dis 202:633-7. 2010b>Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C...
- Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiformeAnand Veeravagu
Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
Clin Cancer Res 14:7330-9. 2008..The purpose of this study was to evaluate the efficacy of a novel 90Y-Abegrin radioimmunotherapeutic agent in murine xenograft glioblastoma models with noninvasive in vivo molecular imaging modalities...
- Combined modality radioimmunotherapy for human prostate cancer xenografts with taxanes and 90yttrium-DOTA-peptide-ChL6ROBERT T O'DONNELL
Department of Internal Medicine, Division of Hematology and Oncology, Section of Radiodiagnosis and Therapy, University of California Davis Medical Center, Sacramento, California 95816, USA
Prostate 50:27-37. 2002..55 MBq;150 microCi) has resulted in durable responses. To make radioimmunotherapy (RIT) more effective, the radiation-enhancing drugs Taxol (paclitaxel) and Taxotere (docetaxel) were tested ..
- Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cellsRuth A Bryan
Departments of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Antimicrob Agents Chemother 53:1679-82. 2009We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes...
- Model prediction of treatment planning for dose-fractionated radioimmunotherapySui Shen
Department of Radiation Oncology, University of Alabama at Birmingham, 35294, USA
Cancer 94:1264-9. 2002Clinical trials of radioimmunotherapy (RIT) often use dose fractionation to reduce marrow toxicity. The dosing scheme can be optimized if marrow and tumor cell kinetics following radiation exposure are known.
- Comparison between radioimmunotherapy and external beam radiation therapy for patients with hepatocellular carcinomaZhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, P R China
Eur J Nucl Med Mol Imaging 29:1657-68. 2002It has previously been observed in animal studies that, at equivalent doses, radioimmunotherapy (RIT) is 2.5 times more effective than multiple fractions of external beam radiation therapy (EBRT) in inhibiting tumour growth...
- FDG-PET in the assessment of patients with follicular lymphoma treated by ibritumomab tiuxetan Y 90: multicentric studyE Lopci
Nuclear Medicine Department, University Hospital S Orsola Malpighi, Bologna, Italy
Ann Oncol 21:1877-83. 2010..is the 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) evaluation following radioimmunotherapy (RIT) with ibritumomab tiuxetan Y 90 in patients with non-Hodgkin's follicular lymphoma (FL)...
- Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomasJohn M Pagel
Fred Hutchinson Cancer Research Center and the Department of Medicine, University of Washington, Seattle 98109, USA
Blood 101:2340-8. 2003..These lymphoma xenograft data suggest that pretargeted radioimmunotherapy using either anti-CD20 or anti-CD45 conjugates is highly effective and minimally toxic.
- Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumorsFares Al-Ejeh
Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, South Australia, Australia
PLoS ONE 4:e4630. 2009..inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, ..
- Rationales, evidence, and design considerations for fractionated radioimmunotherapyGerald L DeNardo
Department of Internal Medicine, Division of Hematology and Oncology, Section of Radiodiagnosis and Therapy, University of California, Davis Medical Center, Sacramento, California 95816, USA
Cancer 94:1332-48. 2002..used in the broader context of administration of multiple, rather than single, doses of radionuclide for radioimmunotherapy (RIT) or other targeted radionuclide therapies...
- A pharmacokinetic model for radioimmunotherapy delivered through cerebrospinal fluid for the treatment of leptomeningeal metastasesYonggang Lv
Department of Biomedical Engineering, The City College of New York, New York, New York 10031, USA
J Nucl Med 50:1324-31. 2009b>Radioimmunotherapy can effectively treat leptomeningeal metastases when radiolabeled antibodies are administered into the cerebrospinal fluid (CSF)...
- Production and characterization of 188Re-C595 antibody for radioimmunotherapy of transitional cell bladder cancerA Murray
Department of Medical Physics, Medical School, Queen's Medical Centre, Nottingham, United Kingdom
J Nucl Med 42:726-32. 2001..MUC1 mucin is overexpressed on bladder tumors and represents a useful target for radioimmunoscintigraphy and radioimmunotherapy. We report on the production and initial tracer studies of a 188Re-antibody complex directed against this ..
- Radioimmunotherapy with an antibody to the HPV16 E6 oncoprotein is effective in an experimental cervical tumor expressing low levels of E6Rébécca Phaeton
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY, USA
Cancer Biol Ther 10:1041-7. 2010..b>Radioimmunotherapy employs systemically administered radiolabeled monoclonal antibodies (mAbs) that bind to tumor-associated ..
- Bio-effect model applied to 131I radioimmunotherapy of refractory non-Hodgkin's lymphomaPeter L Roberson
Department of Radiation Oncology, University of Michigan, 519 W William St, Argus I, Ann Arbor, MI 48103 4943, USA
Eur J Nucl Med Mol Imaging 38:874-83. 2011..Treatment with tositumomab and (131)I-tositumomab anti-CD20 radioimmunotherapy (BEXXAR) yields a cold antibody antitumor response (cold protein effect) and a radiation response...
- Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cellsClaudia Friesen
University Children s Hospital, Prittwitzstrasse 43, 89075 Ulm, Germany
Eur J Nucl Med Mol Imaging 30:1251-61. 2003Beta-irradiation used for systemic radioimmunotherapy (RIT) is a promising treatment approach for high-risk leukaemia and lymphoma...
- Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx--TPF-C-HITAlexandra D Jensen
Dept of Radiation, Oncology INF, Heidelberg Germany
BMC Cancer 11:182. 2011..Combined radioimmunotherapy with cetuximab as well as modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) and ..
- Consensus conference: implementing treatment recommendations on yttrium-90 immunotherapy in clinical practice - report of a European workshopPier Luigi Zinzani
Institute of Hematology and Oncology Seragnoli, Via Massarenti 9, 40138 Bologna, Italy
Eur J Cancer 44:366-73. 2008..This approach would maximise the therapeutic potential of this agent by encouraging its use early in the disease course of follicular lymphomas...
- The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of (188)re-labeled anti-E6 C1P5 antibody in cervical cancer in miceRébécca Phaeton
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY 10461, USA
Cancer 116:1067-74. 2010..The authors of this report recently demonstrated the efficacy of radioimmunotherapy (RIT) targeting viral oncoprotein E6 in the treatment of experimental cervical cancer...
- Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomasW Debinski
Department of Surgery, Pennsylvania State University, College of Medicine, Hershey 17033 0850, USA
Clin Cancer Res 5:3143s-3147s. 1999....
- Targeted radioimmunotherapy for leptomeningeal cancer using (131)I-3F8K Kramer
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Med Pediatr Oncol 35:716-8. 2000..Intrathecal antibody-based targeted therapies may have clinical potential for patients with leptomeningeal (LM) cancer...
Research Grants83
- Targeted liposomal radiotherapy of malignant mesotheliomaJiang He; Fiscal Year: 2010..Highly selective tumor location and targeting are needed. Our long term goal is to develop effective radioimmunotherapy (RIT) for human cancers by marrying radiotherapy with nanotechnology...
- Bispecific Antibody Engineering for AML RITOLIVER W contact PRESS; Fiscal Year: 2010..of this research proposal is to maximize the cure rate of AML using a novel approach employing pretargeted radioimmunotherapy (PRIT) with genetically engineered bispecific antibodies...
- Foundations of Pretargeted RadioimmunotherapyKARL WITTRUP; Fiscal Year: 2009Delivery of cell-killing doses of ionizing radiation to tumors is the objective of antibody-directed radioimmunotherapy (RIT)...
- CD45 Pretargeted Radioimmunotherapy for AMLOliver W Press; Fiscal Year: 2010..The objective of this research proposal is to improve the cure rate of AML using radioimmunotherapy (RIT) targeting the CD45 cell antigen...
- NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALSDonald Buchsbaum; Fiscal Year: 2001..The experiments described in this application will provide answers to these questions. These studies would establish the rationale for human clinical RIT trials in patients with Jp. cancer using HuCC49ACH2. ..
- NOVEL SEROTHERAPY STRATEGIES--PLASMA CELL MALIGNANCIESSTEVEN TREON; Fiscal Year: 2004..treatment approach for MM and WM patients involves use of antibody mediated immunotherapy (serotherapy) and radioimmunotherapy. As part of our efforts to develop serotherapy for PCD, we have sought to target tumor selective antigens on ..
- Hematopoietic Cell Transplantation for Hematologic MalignanciesStephen Forman; Fiscal Year: 2007..This grant consists of four translational clinical projects and three cores. Project I entitled "Radioimmunotherapy-based Transplant Regimens for Treatment of B-cell Lymphoma and Acute Myelogenous Leukemia" is focused on ..
- PRETARGETED RADIOIMMUNOTHERAPY OF CD20+ LYMPHOMASOliver W Press; Fiscal Year: 2010..The objective of this research proposal is to optimize radioimmunotherapy (RIT) of B cell lymphomas utilizing pretargeting amplification strategies to improve the efficacy and ..
- BIFUNCTIONAL CHELATING AGENTS IN TUMOR LOCALIZATIONClaude Meares; Fiscal Year: 1999..Antibodies have been conjugated to metal chelates for radioimmunotherapy and studied extensively in recent years, and are in clinical trials at various stages...
- TWO COMPARTMENT MODELS TO IMPROVE BRAIN TUMOR THERAPYEdward A Neuwelt; Fiscal Year: 2010..In aim 4 clinical trials of immunotherapy, radioimmunotherapy, and neurotoxicity in PCNSL will be conducted...
- TWO COMPARTMENT MODELS TO IMPROVE BRAIN TUMOR THERAPYEdward Neuwelt; Fiscal Year: 2009..In aim 4 clinical trials of immunotherapy, radioimmunotherapy, and neurotoxicity in PCNSL will be conducted...
- TWO COMPARTMENT MODELS TO IMPROVE BRAIN TUMOR THERAPYEdward Neuwelt; Fiscal Year: 2009..In aim 4 clinical trials of immunotherapy, radioimmunotherapy, and neurotoxicity in PCNSL will be conducted...
- Radioimmunotherapy of Acute LeukemiaEneida Nemecek; Fiscal Year: 2007....
- Foundations of Pretargeted RadioimmunotherapyKARL D WITTRUP; Fiscal Year: 2010Delivery of cell-killing doses of ionizing radiation to tumors is the objective of antibody-directed radioimmunotherapy (RIT)...
- Novel glutamate conjugates for radiotargeting PSMAJohn Babich; Fiscal Year: 2004The development of novel approaches for radioimmunoimaging and radioimmunotherapy is driven by the high incidence and mortality rate associated with prostate cancer in the United States...
- PRETARGETED RADIOIMMUNOTHERAPY OF CD20+ LYMPHOMASOliver Press; Fiscal Year: 2001..pretargeting amplification strategies to improve the efficacy and decrease the toxicity of conventional radioimmunotherapy (RAIT)...
- Improved Tumor Radiotherapy by MORF pretargetingDonald Hnatowich; Fiscal Year: 2005Despite several decades of effort, conventional radioimmunotherapy of hematopoietic and especially solid tumors is still providing marginal results. As such, alternative methods of treating these diseases are needed...


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I think this is probably a better exercise to go through now as opposed to after the draft. The status of the top guys should not really change from right now to Jan/Feb 2013. Giolito has a chance to improve/hurt his stock quite a bit I suppose, but other than him, we should be able to figure out roughly where these guys should slot next year. We have a chance to be realistic about it now, before bias sets in, though there might be some bias toward the whole group getting high rankings.
Here are my guesses...I don't want to get into too much detail over the explanations right now, but I'd love to see other rankings and maybe we'll get into some detail later.
22. Byron Buxton
29. Carlos Correa
35. Mike Zunino
43. Mark Appel
55. Kevin Gausman
There are a few other wildcard types (namely Giolito and Zimmer) that I haven't ranked here, and I wouldn't be shocked to see one or two of them crack the top 50 possibly. I these are the consensus top 5 at this point. This is how I think their general industry ranking will shake out.

subset: commoncrawl


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Patrick J. Buchanan - Contact me
08/18/14 - Is Ferguson Our Future?
08/14/14 - Let Congress Vote on Iraq War III
08/11/14 - ISIS And Iraq: Let Middle Easterners Take The Lead In Fighting This Newest Middle East War
08/04/14 - Nixon—Before Watergate
07/31/14 - Stop the Coming Obamnesty!
07/28/14 - A GOP Ultimatum To Vlad


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Whether you are looking for Music, Hotfrog is the place to go to. Browse the businesses below in TOOMBUL, QLD or extend your search to nearby suburbs by using the left navigation menu. Hotfrog makes your search easier.
Toombul, QLD
Toombul Music is a record store located on Brisbane's Northside and has been established for 40 years, they also specialise in Musical Instruments and Home Theatre
Musical InstrumentsBuffett
Musical Instruments Or SuppliesDvdsBuffettHi-Fi Equipment
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Chris Johnson will be on Ink Masters, Tuesday July 23rd. I encourage everyone to tune in, as it should be highly entertaining, as CJ always is.
Fanspeak has the fantasy outlook for some Titans players. Namely the RBs.
Damian Williams is looking to spread a positive message and to promote higher learning. I really hope D-Will sticks as he has always seemed like a good guy, maybe he'll put it together this year.
The Tennessean has a preview of the Titans' running backs. This group looks to bring back the thunder and lightning aspect that we missed with Harper as the backup. Here's to a punishing run game that exhausts other teams defenses.
Do you like John Hamm? Like seeing professional athletes get roasted? Then you'll like this monologue from the ESPYs last night, which was about 1 or 10 "Where's the white suit, Ray?" jokes from being perfect. Really hilarious.
Quote of the Day: "Why do they call it rush hour when nothing moves?" -Robin Williams
More from Music City Miracles:


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Fort Custer National Cemetery
|Year established
|Augusta, Michigan
|United States
|United States National Cemetery
|770.4 acres (311.8 ha)
|Number of graves
Fort Custer National Cemetery is a United States National Cemetery located just outside of the Village of Augusta in Kalamazoo County, Michigan. It encompasses 770.4 acres (311.8 ha), and as of the end of 2005[update] had 20,656 interments.
Named for General George Armstrong Custer, the original Camp Custer was built in 1917 as part of the military mobilization during World War I. After the war, it also served as a demobilization camp. The cemetery itself was not created until 1943. During World War II Fort Custer was expanded to serve as a training ground and as a place to hold German prisoners of war, 26 of which died while in captivity and were buried in the cemetery. Sixteen of the German POWs were killed in an accident when their truck collided with a train as they were returning to the fort from a work detail on a sugar beet farm near Blissfield, Michigan. The other 10 died from natural causes.
It was not until 1981 that Fort Custer cemetery officially became Fort Custer National Cemetery, receiving a large plot of land from the Fort Custer National Military Reservation for expansion. In 1997 another expansion was made, with the addition of 60 acres (24 ha).
Notable monuments[edit]
- The Avenue of Flags, a row of 152 flag poles along the main road of the cemetery, as well as the main flagpole and an additional 50 flag poles, one for each state flag, in a semicircle at the road end.
See also[edit]
External links[edit]
Coordinates: 42°20′10.7″N 85°18′58.3″W / 42.336306°N 85.316194°W


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Faculty Forums
Practices to Promote Academic Integrity- September 27th, noon, Frock Conference Room
This forum will feature a discussion of the techniques that faculty at LVC use to prevent acts of plagiarism and cheating inside and outside of class. We will also discuss important policies and useful tools that aid in preventing students from engaging in acts of academic dishonesty. Lunch will be provided. RSVP to email@example.com or 6511 by September 25th if you plan to attend.
The Flipped Classroom- November 22nd, noon, Frock Conference Room
This forum is a follow-up to last month's workshop and will feature Noel Hubler, Professor of Philosophy, and Anderson Marsh, Professor of Chemistry as they speak about how they use the "flipped" methodology in their classrooms. All faculty are invited to come and participate in the discussion of what a flipped classroom can look like at Lebanon Valley College. Lunch will be provided. Please RSVP to firstname.lastname@example.com or 6511 by November 20th if you plan to attend.
Lebanon Valley College
101 N. College Avenue
Annville, PA 17003-1400


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Utility debt-limit ballot item proposed
Last Updated: 15:04 July 22, 2013
The city's proposed ballot measure, according to documents released by the city, would set a limit on the amount of debt allowed to acquire Xcel Energy Inc.'s distribution system and on capital costs during the first six months of the municipal utility's operations.
The dollar amount of the debt limit was not stated in the paperwork released Friday, but it would have to be stated before city council could give the measure final approval in August to be included on the November ballot. The city's measure would not require any other votes down the line before the utility would be allowed to issue debt.
On June 28, the group Voter Approval of Debt Limits turned in a petition asking that a debt-limit measure be placed on the November ballot. That measure proposes a change to the city's charter that would require voters to approve the amount of any utility debt issued as well as the total cost of debt repayment.
The citizens measure would also require that the utility's service area not extend beyond city limits unless registered voters outside the city served by the utility were permitted to vote in the debt-limit elections.
City staff's alternative measure would not allow nonresident customers who would be served by the municipal utility to vote on the debt-limit question. However the measure does propose an amendment to the city charter that would allow out-of-city customers to serve on the utility advisory board. And the measure clarifies that nonresidents' rates would be the same as those for city customers.
On Friday afternoon, city clerk Alisa D. Lewis certified the citizen petition, confirming that enough signatures were valid for the item to be placed on the November ballot. City council will set the ballot title in a special meeting after its Tuesday study session, and then formalize its placement on the ballot on Aug. 20.
If city council formally decides in August to put the alternative ballot measure submitted by staff on the November ballot as well, both could pass. In that instance, Boulder spokeswoman Sarah Huntley said, whichever measure passed with more votes would prevail.
City council will hear a first reading of the ordinance regarding the alternative ballot measure at its special meeting on Wednesday.
At a study session Tuesday, the council will hear from third-party evaluator PowerServices Inc. as to whether that company believes the city's proposals for a municipal utility demonstrate that the city could run such a utility while meeting conditions of the city charter.
Assuming PowerServices Inc.'s findings confirm that a city utility could meet charter conditions, council will vote on an ordinance that formalizes the findings.
Council, on Wednesday, will also vote on a condemnation ordinance that would set in motion the acquisition of Xcel's distribution system. The first steps of that process, carried out over the next few months, would be to begin good-faith negotiations with Xcel and to identify all assets to be acquired and get appraisals of their value. The ordinance states that, if negotiations fail, condemnation action likely would be filed no earlier than January 2014.
More breaking news...
CEOs: Health care administrative costs still rising
Lacy replaces Kam Mofid, who left the company to pursue other interests, according to a
Brewery takes space in former Butterball building
New Belgium hosting roundtable on EPA water rule


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1 played on Radionomy
C'est Ça Qu'on Aime


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IN WHICH a 40-year old Commodore supporter with more mouth than sense travels 4500 miles in six days with no socks to attend his first home game in sixteen years.
I knew going in that this game would be a gimme. I just couldn't take the chance that like Notre Dame in 1996, my last memory of Vanderbilt Stadium would be defeat snatched from the jaws of victory. So yeah...Cupcake Saturday in review:
* I was taken in at 8 AM by @Vanderboze and @VandyAPB, who know how to bring the Vandy Lifestyle. We had champagne, two kinds of bourbon, there were bacon biscuits and artfully-arranged muffins, and I got to wash down Krispy Kremes with PBR and some sort of Jäger-peach shot, and you don't get to do that every day. I also actually met people who knew one of my old grad school teammates. I was pleased to hear that his career is exactly what he wanted and that he is apparently the same as ever. To everyone I met or missed: thanks for everything. It may not be my house anymore, but the new residents are all superlative hosts.
* It was pointed out, and I concur, that for an 11:30 kickoff against a 1-AA opponent coming off a bad road loss and 0-2 start? The turnout (especially on Dore Alley) was better than I would have expected. I don't think we even had Star Walk in my day, but the look on those guys' faces...they weren't taking anyone lightly. They looked like they were out for blood, and my first thought was "we're gonna SLAUGHTER those Presbyterians."
* The dance team all wore #5 jerseys. I don't know why and it would be irresponsible to speculate, where by "irresponsible" I mean "fun as hell." Nevertheless, Warren Norman will hereafter be known as the Ladies' Choice. And he finally got legit playing time, and delivered the goods. WarNo is free. Let's hope it sticks.
* Silicon Valley's own Austyn Carta-Samuels got his first VU start, which must have been awkward for Aaron Rodgers (sighted at Star Walk) when Jordan didn't do anything but hold for kicks all day. The fact that a walk-on was sent out to mop up strongly suggests to me that we may have seen the last of Jordan Rodgers for a while; I would say "quarterback controversy" but right now it doesn't look like CJF thinks so. Nobody's job is safe or to be taken for granted, and if you don't perform you'll give way to somebody who can. Which is a change from the days when we limped along with incumbents for months or years at a time while never taking a chance with another player (I think the "Bring in da Funk" line goes here).
* One thing I really don't like, though, is the parade of starters back there returning kicks on special teams. I still have PTSD from watching Tyrone Prothro's famous injury against Florida years ago, and it confirmed in me that there's no reason EVER for a starter to be out there ESPECIALLY late in a blowout. I don't know what CJF is playing at, but the only name guy who should be returning kicks right now is Kimbrow. Maybe. NEVER Zac Stacy and NEVER Jordan Matthews. I mean, what the actual hell?
* The problem with a 58-0 win is that it tells you nothing about your team. ACS went out with a fish, a barrel, and a loaded gun. Is he the guy to take down Georgia? We are no closer to knowing than last week. We got a win, built a little momentum, restored morale ahead of the toughest three-game stretch on the schedule, and maybe that's enough. If we come home to face Florida at 1-4, though, the 1 may not make a lot of difference to us.
* There is a school of thought that says games like this ought not happen. From a fan standpoint, I agree. I'd much rather schedule, say, San Jose State on the road - aside from the purely selfish considerations, a road game against a very beatable but still I-A opponent is a better thing for the performance of this squad in the long run. But we aren't yet at a point where we can take any wins for granted (Duke 2008 anyone?) and as Arkansas and Kentucky learned, there's cupcakes and then there's cupcakes. It's the way of the world now, and much as I wish it wasn't, there's not a lot of percentage in making our stand for better scheduling until it no longer makes a difference to things like our prospects for bowl eligibility.
* On to Athens. I fully expect this to be the toughest road game of the CJF era, and how we come out of next Saturday will tell us a lot about this team and which way they're headed.


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For the Pierce fight that was wrongly, or dipshittedly, judged. How does this work for the BECW? I know it's a pain in the ass but it brought me 4 more points and I'm sure it did for some other fellow BE'ers as well! I want my points god damnit!
I really don't care that much but seriously give me my fucking points.
Love you long time, and I need 3 more words so here's you go.


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- Faith schools debate -- New Internationalist
Teaching religion should be left to churches and/or theological centres, whatever their denomination...
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APPLE VALLEY -- A night of alleged heavy drinking for one man resulted in a seven-hour standoff with sheriff's officials early Sunday morning, according to witnesses and San Bernardino County Sheriff's officials. This marks the fourth time in less than a week that law enforcement has been involved in a similar deadlock in the county.
The unidentified man was arrested on suspicion of discharging a weapon into an inhabited dwelling, officials said.
Residents who live near Pah-ute and Navajo roads reported hearing several gun shots around 2 a.m. Sunday morning.
San Bernardino County Sheriff's deputies arrived and the man reportedly ran into his home on Algonquin Road, officials said. Deputied ordered the man to come out of a home, but he refused.
SWAT personnel were called out and surrounding homes were evacuated around 5 a.m., frightened neighbors said.
The man eventually surrendered just after 9 a.m.
It was not immediately clear if the unidentified man was armed when he was taken into custody.
Some residents said the entire episode may have been sparked by a domestic situation, but sheriff's officials said the man had not been involved in any kind of argument or fight and appeared just to be extremely intoxicated.
One woman, who did not want to be identified, called the people who lived in the home from where the man was taken problematic stating deputies have been summoned to the home several times. More to come.


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Boards > The Red Board
Blizzard highlights looming game of Super Bowl roulette
<< < (3/3)
--- Quote from: Morgan on February 12, 2013, 07:00:59 PM ---Seems like every winter we hear of major snow storms hitting the NE. Thousands of flights get cancelled. The difference between a SB and the conference championship would be a ton of news, radio, TV media show up for the SB. Having flights cancelled and roadways blocked would be a major show stopper.
Even the Tampa Bay Lightning had a game postponed until April due to weather up there.
Really hope it happens in 2014 to teach the NFL a lesson to leave a good thing alone.
--- End quote ---
Buffalo & New England are 2 places to stay away from if your worried about the snow. New York and Philly I wouldn't worry about it much. Those storms move by the year it seems too...There was one year Washington got nailed with the snow and up this way we barely got anything, that was 3/4 years ago.
I think Baltimore would be and awesome city to host a superbowl...though from what I know parking is horrible, but the harbor would be cool hang out for the superbowl weekend.
The NFL will have an extensive contingency plan in place to account for bad weather : a possible Saturday start or delaying the game a few days if necessary.
Remember that this in the event that New Jersey got hit by a megastorm. Last year NJ got some snow before Halloween and then didn't get any snow all season. Totally random panic. Why this didn't dawn on the NFL before is odd.
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The heady scent of basil has been said to drive men wild. So much so that women have been known to dust their bosoms with dried or powdered versions of this spicy herb. While basil may help increase circulation and promote heart health, it has long been associated with stimulating sex drives and promoting fertility. A fruitful combination, don't you think?
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Brandon Marshall wore his green shoes to make a statement about mental illness during Thursday night's Bears-Giants game.
Now, he's selling them to raise money to fight mental illness. The shoes are up for auction with the bidding currently at $2,000.
Marshall says he'll donate the proceeds to his foundation which helps people cope with mental illness.
The NFL is expected to fine Marshall at least $10,000 for wearing the non-standard shoes, but considering he scored two touchdowns in them, it might be worth it.
To make a bid on Marshall's green shoes, visit BuyBrandonsShoes.com.
To find out more about what his foundation is doing to bring about mental health awareness and how you can help, visit The Brandon Marshall Foundation's website.
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WVDE News
Request For Proposal WV Service Learning Program
Posted: March 14, 2002
The Corporation for National Service (CNS) provides funding to encourage K-12 public school students to become more involved in civic engagement through �Learn and Serve-America.�
This document provides West Virginia�s: program objectives; instructions on how to apply for a grant; steps for writing a school-based proposal; a cover page form, budget form; assurances pages; a proposal rating form; and, a sample project description form.
West Virginia public school personnel may use this information to write a proposal (application) for obtaining funding for local service-learning programs during the 2002-2003 school year. The deadline for proposal submission is 4:00 p.m., Monday, April 29th, 2002.
For more information about the Corporation for National Service, or Learn and Serve America, K-12, contact http://www.cns.gov
The actual RFP Document can be downloaded following this link http://wvde.state.wv.us/tt/2002/RFP2003-LS.doc It is provided in Microsoft Word Format
West Virginia Department of Education
Topics: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
For suggestions, questions, problems contact the webmaster
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Authorities said they seized $560,000 worth of meth and heroin in two separate drug busts at the border on Thursday.
The U.S. Customs and Border Protection said Luz Aidee Cubedo Figueroa, 37, of Hermosillo, Sonora, Mexico, had 12 packages of crystal meth weighing more than 19 pounds in the trunk of her vehicle as she was trying to cross the Dennis DeConcini Port.
In the second case, officers at Mariposa Port found 13 packages of methamphetamine and heroin within the middle seat of a truck belonging to Hector Octavio Hernandez-Mazon, 25, of Nogales, Sorona, Mexico.
Figueroa and Hernandez-Mazon were turned over to U.S. Immigration and Customs Enforcement's Homeland Security investigators.
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A Fulton County judge denied Atlanta rapper Gucci Mane's request to do community service following an assault arrest.
Gucci Mane, whose real name is Radric Davis, faces assault charges over a fight at an Atlanta nightclub earlier this year.A fan says the rapper hit him over the head with a champagne bottle.Davis' attorney says a trial date hasn't been set, but he thinks it could be in November or December.
WJBK-TV | Fox 2 16550 West Nine Mile Rd.Southfield, MI 48075Main Station: (248) 557-2000Newsroom: (248) 552-5103


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Today's snowfall got a fairly insignificant start in Williston this morning.
It started as a light dusting and slowly built in strength.
And even in its early stages workers here were shoveling sidewalks, trying to keep away the slippery conditions.
Our camera was there as some people who are spending their first winter in North Dakota were experiencing the white stuff.
"How do you like the weather here? I hate the weather here. Why? I swore when I came up here I wasn't spending a winter here but somehow I'm still here. And how many winters is this now? Oh, this is my first - I'm from Utah." "What do you think of the weather? It's wonderful. You like this winter? Yeah I do. Where you from? Las Vegas, Nevada. And you came here for the snow? Yeah, I came here just to experience the winter - I hadn't been in winter for 20 years."
Williston has received about two inches of snow today.
And here's a reminder from Minot police - there are many very slippery streets and some vehicles stranded by the ice - so please drive slowly tonight and watch out for stalled cars.


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Air Cargo
Global air cargo traffic surged 5.8 percent in July from a year ago and likely will continue to increase in the coming months, driven by accelerating economic growth in key Asian markets, according to the International Air Transport Association.
The second-quarter recovery that gave air and ocean cargo such a welcome boost looks set to continue its momentum well into the second half as the latest economic and freight indicators show some positive numbers.
Deutsche Post DHL will use India to pilot the development of its e-commerce business model for the Asia-Pacific region via subsidiary Blue Dart Express.
Iceland's Bardarbunga volcano has kept the local meteorological office busy, with the red level warning being
Weekly wrap-up: ILWU ratifies deal with PNW grain handlers, reaches tentative agreement on health benefits with PMA
Members of the International Longshore and Warehouse Union ratified a new collective bargaining agreement with grain handlers in the Pacific Northwest, ending a two-year battle between the two parties.
The air cargo industry has been battling declining market share for years as cost-sensitive shippers move long-haul cargo from air to ocean transport, but that trend may be coming to an end, PIL Managing Director Teo Siong Seng says.
Rising revenue at Air China in the first half was not enough to lift cargo yield into positive territory, and the mainland carrier struggled against stiff competition and a weakening RMB-U.S. dollar exchange rate.
A U.S. appellate court panel ruled that as many as 2,300 FedEx Ground drivers in California and Oregon were employees, not independent contractors, when they worked for the package delivery company in the last decade.
A quarter of Vietnam's trade by value is shipped by air, and the International Air Transport Association (IATA) expects the country to be the world's fastest-growing air cargo market over the next three years, expanding at 6.6 percent a year.
Air freight pricing is stable for the moment, but with the holiday season on the horizon Drewry is predicting prices will shoot up in coming months.


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Clovanol is unique pure clove oil made from the flowering buds. This steam-extracted oil is highly concentrated for ideal results. Cheaper versions are made from inedible leaf oils. Clovanol can be rubbed on gums or used as a mouth wash for fresh breath. Clovanol is also a very potent antioxidant, one of the highest naturally occurring antioxidants, so it is also recommended to take internally.
Warnings: Keep out of reach of children. As with all dietary supplements, consult your healthcare professional before use. See product label for more information.


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Salsamania Dance Company
Salsamania 2X World Latin Dance Cup Champions is recognized as the premier salsa dance company in the Bay Area performing "San Francisco Style" salsa (a fusion of New York and Puerto Rican styles). Salsamania dancers are known for their flamboyant spirit, complicated footwork and patterns "On 2" and their ability to execute these to fast music.
Open Auditions
Saturday , August 23, 2014 at 12pm
Just Dance Ballroom
2500 Embarcadero
Oakland, CA
for More Info check here Open Auditions
On2 Series Starts August 24, 2014
ON 2 Three Month Training Series (Open for all Social Dancers and Performers)
If you are an intermediate to advanced dancer wanting to refine your skills "On 2", the On 2 Training Team is the place to be. Recognized as one of the best salsa dance training programs in the world, this On 2 training program will teach you all the details of technique, timing, styling, musicality, footwork and partnering that will let you shine socially on the dance floor. The On 2 Training Team is also the first step to joining one of Salsamania's performance teams. Dancers who consistently excel in the On 2 Training Team may be invited to join one of the performance teams of Salsamania.
For More info check On2 Series
On1 Series Start September 16, 2014
On 1 Three Month Training Series (Open all on1 social dancers and performers)
Make sure to register by August 31st before price goes up....
For More info check here On1 Series
2x Team WOLD LATIN DANCE CHAMPIONS
Recent Awards and Honors
2013 Salsamania Dance Company World Latin Dance Cup Champions
1st place - Salsa team (Salsamania)
1st place - Same gender male (John and Andrew)
1st place - Over 65 (Isabel and Jonathan)
1st place - Proam (Sheena and Andrew)
2nd place - Amateur Salsa team (Latin Vibe)
2012 World Latin Dance Cup Champions
- 1st Place - Male Same-Gender Division
- 2nd Place - Amateur Salsa Team Division
2011 World Latin Dance Cup Champions
- 1st Place - Salsa Team Division
- 1st Place - Male Same-Gender Division
- 1st Place - Amateur Salsa Couple Division
- 3rd Place - Female Same-Gender Division
- 3rd Place - Salsa On 2 Couple Division (John Narvaez & Liz Lira)
2010 - 2012 US Salsa Open Top Teacher
2010 - 2011 US Salsa Open Top Dance Company
2011 San Francisco Bay Area Dance Troupe Competition Winners


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Just thought I'd throw out a heads-up that the Vancouver Canadians play the Boise Hawks tonight in the short-season Northwest League, and because the Hawks know the value of the internet, they're streaming video of the game on their website - for free.
The link is right here, and the game starts at 6:15pm pacific time.
Catch up with 1st rounder Travis Buck, and starting pitcher Trey "Phaser" Shields, as the soon-to-be Athletics fight to retain their western division lead - just like it was on ESPN!
Now, why on earth doesn't every minor league team do this?
Free streaming video enables people to really connect with their team, rather than just going out to see them one or two times a season, and encourages a connection between fans and players that is hard to get in minor league ball, when the players move up at the end of each season.
Heck, there's one team in the NWL, the Tri-City Dust Devils, that doesn't even have an audio webcast... now that's slack!


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Technical Reference for the WVDE School Closings XML feeds
Last revised: 2014-03-04
This document provides a technical reference to the fields used in the XML feeds for our school closings system. It is intended for those who wish to programmatically read our closings information and act upon it based on the information provided.
Feeds for public schools may be accessed via one of the following URL formats:
for the state-wide public school feed,
for feeds restricted to a particular county (substituting the county's name for the word "countyname").
Feeds for private schools and colleges follow a similar format:
for all colleges, and
for all private schools. XML feeds are also available for a few specific private schools and colleges. These are handled on a case-by-case basis and available upon request.
Each feed shows information for today's date and later. If you have a need to keep information in excess of this limit, you are advised to save the feed information to your own database.
All our XML feeds are standard XML documents, and you should therefore not rely on these fields being in the order listed below. The WVDE reserves the right to change this information at any time. You are advised to refer to this document for any future changes.
West Virginia Department of Education
Topics: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
For suggestions, questions, problems contact the webmaster
State Board | Department | Teachers | Parents | Students | Community | Data


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Three men are behind bars Tuesday after a failed attempt to steal a man's pickup truck from a parking lot located at 21st Street and Indiana Ave.
Police say the incident occurred shortly before midnight Monday when George Henderson, Marcus Denson, and Shawn West made an attempt to steal a Dodge Dakota at gunpoint in the Covenant Hospital parking lot. The victim managed to flee from the scene and ran to the emergency room of Covenant where he called LPD.
Lubbock Police located the suspects in the 2100 block of Ave. T. Henderson and Denson were located at a house and taken into custody. The third suspect, Shawn West, took off on foot and was located in a doghouse and found by the K-9 unit. He was taken and released from UMC after being treated for dog bites.
The truck theft was unsuccessful, police say, because none of the men knew how to drive a standard shift transmission.
All three men are at the LPD Detention Center. Two handguns were recovered along with stolen property from the victim.
Copyright 2011 KCBD NewsChannel 11.
5600 Avenue A
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Eau Claire (WQOW) -- The UW-Eau Claire football team is looking forward to its home opener Saturday, but after two road losses, the Blugolds will face another tough opponent: Pacific Lutheran is currently ranked tenth in the D3 Football.com poll.
All of UWEC's first three opponents are currently ranked in the Top 25. The Blugolds got a bye last Saturday, and players say they were able to refresh and regroup. Now, they're ready for the challenge ahead.
"I think the energy is really high," says Blugolds junior cornerback Thurgood Dennis, "I think if you go to Carson Park on Saturday you're going to see a bunch of guys that want to have fun on the football team for the first time. Defensively, I think we had a miserable first two weeks, the second half of St. John's we kind of turned it around a little bit, but right now I think we're ready to go out there and compete and have fun and that's going to be a first for us this his season."
"That bye week is huge," says UWEC senior tight end Alex Delebreau, "because it gives us a chance to work on our rhythm a little bit more, add a few things, maybe make some adjustments, and I think it's just a confidence thing, getting out there, getting your feet wet, you got a lot of new guys out there, new quarterback, it's just get your feet wet before this conference schedule comes and I think this week you'll see a big change in our offense."
This will be the first-ever meeting between UWEC and Pacific Lutheran. Kickoff between the Blugolds and Lutes is set for 12:00 noon, Saturday, at Carson Park.
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4938 Posts in 16827 Topics by 1490 members
Installing SilverStripe
SilverStripe Forums » Installing SilverStripe » Install 2.4 with SilverCart Error
Getting SilverStripe up and running on your computer and on your web server.
Moderators: martimiz, Sean, biapar, Willr, Ingo, swaiba, simon_w
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Install 2.4 with SilverCart Error
5 August 2012 at 12:13am
Hi I've downloaded a install package from the SilverCart developers. And once I had created a DB and setup a db user I run the site http://localhost/fineart (name of site). And I got the following error when all of th details had been processed:
Warning] file_get_contents(C:\wamp\www\fineart//fineart/silvercart_customer_rating/css/SilvercartCustomerRating.css) [function.file-get-contents]: failed to open stream: No such file or directory
GET /fineart/home/successfullyinstalled?flush=1
Line 120 in C:\wamp\www\fineart\requirements_engine\RequirementsEngine.php
Now I'd expect this to be a Silvercart issue but looking in the Apache logs I get:
fineart/silverstripe-cache/manifest-main) [function.fopen]: failed to open stream: Invalid argument in C:\\wamp\\www\\fineart\\sapphire\\core\\ManifestBuilder.php on line 120, referer: http://localhost/fineart/themes/blackcandy/css/layout.css
Is there a config issue going on here? It appears it's adding the domain (website) name twice which is why it can't find the css file to run the manifest on. Or is it a problem with installing the site locally?
Many thanks,
Community Member
14 Posts
Re: Install 2.4 with SilverCart Error
6 August 2012 at 7:10pm Last edited: 6 August 2012 7:12pm
Hi Kinsley,
I think I had a similar behaviour when I tried to run SilverStripe and SilverCart with MAMP from a subdirectory. If this is the case in your setup, moving the project away from the subdirectory into the webroot should solve the problem.
However, if you just want the checkout SilverCart in terms of functionality, you can use our hosted demo and have your installation up and running in a few minutes.
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11:07 AM, Friday, August 15
Louis F. Hons, 92, of Hobson, died Wednesday, Aug. 6, 2014, in Karnes City. Mr. Hons was born Jan. 23, 1922, in Hobson to Joseph Hons and Pauline Ulrich Hons. He was a farmer and maintenance mechanic and loved playing the violin. He was also a mem...
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It was a really great All-Star game last night. The good guys won, there was a lot of scoring, ex-Braves and current Atlanta Braves were all over the field, and Chipper Jones had some special moments. Fox and MLB did a good job of covering those special moments, from the pregame speech to the in-game interview. Ken Rosenthal has a terrific story up about Chipper at the All-Star game; it really did bring a tear to my eye:
On Monday, when Jones met privately with the FOX broadcasters, I asked him if it struck him as odd that his oldest son was only five years younger than the Nationals' Bryce Harper, who at 19 is the youngest position player in All-Star history.
"Yes," Jones said. "My 14-year-old is pretty good. He's going to be a pretty good player. But I daresay I wouldn't put him in the category of Bryce. Bryce is a man-child. (Mike) Trout is, too.
"I think it's great that you have the two of these guys who are destined to be the face of the game for the next 15 to 20 years, I really do.
"You've got the five-tool guy in Trout who can steal bases and be one of the most dynamic leadoff hitters in the game. And you've got Harper, who has the big outfield arm and huge power - huge power. He's going to hit 40. And they're playing on good teams in good markets. They're going to be all over the TV all the time."
Just as Jones once was on TBS, something that numerous young All-Stars noted over the past two days.
They all grew up watching Chipper.
And soon, he will be gone.
There's so much of Chipper in those quotes, but also so much of Bobby Cox. That ability to compliment other players, and truly mean it, that is quintessential Bobby, and now it seems to be ingrained in Chipper's DNA -- the building blocks of a great manager.
"To be honest, I don't want the lifestyle anymore," Jones said. "I don't want the schedule, the major league schedule anymore. I've been living out of suitcases for 23 years."
We'll see if a year or two away from the game will change his mind. I bet it does.


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In science this unit we are learning about different forms of structures, how to build and design a structure correctly, the different types of load and so much more. I am going to list the different types of structures and explain my definition. I hope after reading this post you will understand the different structures.
Solid Structures: most solid structures are solid all the way through, because a mountain is a solid structure but it may have caves in it, as well as an apple may have a worm hole in it. A solid structure weighs more than a hollow structure of the same size and made of the same material.
Frame Structure: is a network of joined parts. The parts are called structural components. Frame structures can exist as just the frame or as a frame covered by a coating. For example; a tennis racket and a spider web are structures that are just frames. Umbrellas, and cars consist of a frame covered by a sort of material.
Shell structures: most strong, hollow structures are called shell structures. If you have blown up a balloon, been in an igloo, or seen an egg; you know what a shell structure is. Since shell structures have space inside them, they often make good containers. They also use very little material in their construction. This means they are very light for its size. Clothing can even be considered shell structures.
Combination Structures: Many structures are called combination structures because they are combinations of shell, frame, and solid structures. A house is an example of a combination structure because all of the materials are put together into a frame structure, then the roof is added which is a shell structure, and the materials (nails, plywood, bricks) are the the solid structures.


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Hang power snatch + Snatch 1+1 x 10, Rest 2 minutes after each. Increase weight so long as technique does not suffer.
Rest as needed
10 KB swings EMOM x 10 minutes, The heavier the better.
Optional supplement
Accumulate 5 minutes total time in Super man hold
Ice Monster 3! Is open for registration! This price won't last long…