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Docks Oyster Bar633 Third Avenue, Third Avenue at 40th St, New York, NY 10017
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(212) 986-8080
Docks Oyster Bar is the best oyster bar and seafood restaurant in New York City and will leave you full of great food and great fun! Live music by the United Jazz Trio lead by bassist Oleg Osenkov will amaze the guests in a wonderful setting. At Docks Oyster Bar, diners can experience all of the sea and none of the seasickness!
The Zagat Guide, America's most prestigious dining and shopping guide, gave high marks for Docks Oyster Bar in an extensive review. Zagat quoted Docks Oyster Bar to have well-prepared fish, bivalves galore, briskly professional servers, and an active happy hour! Don't let everyone else have all the fun and hop on down for the best oysters in New York! Let your tastebuds swim in the blue crab soup. Go on an adventure with the mediterranean seafood couscous. Try a flavorful Maine lobster roll, oyster sampler, or salmon filet. The options are endless at this hotspot.
Bring your birthday parties or wedding showers to Docks Oyster Bar and Seafood Grill. They have pre-fixe options available for parties from 20 to 350 guests. Call Liz Freeman for any questions you may have about booking an event or party.
For the best seafood restaurant in Midtown East, look no further than Docks Oyster Bar!


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'Idol' fans: Get ready for an 80s flashback
Tonight's "American Idol" contestants will sing "songs from the year they were born." That means it's 80s flashback time. Seven of the eight remaining contestants were born in the 1980s. Only youngster Allison Iraheta is a 90s child, born in 1992. (Am I the only one who feels old?)
Here's what we have to look forward to:
The oldest contestant, Danny Gokey, will sing a song from1980. Topping Billboard's Hot 100 that year: Blondie's "Call Me", Pink Floyd's "Another Brick In The Wall", Olivia Newton-John's "Magic", Michael Jackson's "Rock With You" and Captain & Tennille's "Do That To Me One More Time." I don't see Gokey singing any of those songs. I think he'll go with some kind of ballad from the likes of Air Supply or Bill Joel. Though, if he chooses to sing Pink Floyd, you just might hear me screaming from across town.
It will be interesting to see what Adam Lambert picks from 1982. He often surprises with his choices, and he could go harder into metal or punk or more funky with a modern rock choice. Here's a look at the top 5 songs from The KROQ Top 106.7 Songs of 1982: The Clash's "Rock the Casbah," A Flock of Seagulls's "I Ran (So Far Away)," Soft Cell's "Sex Dwarf," Missing Persons's "Words," and The Human League's "Don't You Want Me." My vote: The Clash.
The five other contestants will be choosing from the mid-80s, where artists like Prince, Madonna, Whitney, and Michael ruled the charts.
Three contestants (Kris Allen, Matt Giraud and Scott MacIntyre) will sing songs from 1985. According to Billboard, to top 5 songs that year were: Wham!'s "Careless Whisper", Madonna's "Like A Virgin", Wham!'s "Wake Me Up Before You Go-Go", Foreigner's "I Want To Know What Love Is" and Chaka Khan's "I Feel For You." All three contestants have been inconsistent in their ability to pick good songs this season. Though, Allen has received praise the past two weeks. This may be the week that makes or breaks these singers.
Lil Rounds will choose a song from 1984, where Tina Turner's "What's Love Got To Do With It was No. 2 on the Hot 100; and Anoop Desai will choose one from 1986, where Lionel Richie's "Say You, Say Me (Title Song From "White Nights")" hit No. 2. These two singers have struggled the most this season and I predict another bad night. Get ready for each to butcher another well-known, shouldn't-try-it song tonight.
Since I grew up in the 80s listening to these song, I'm much more optimistic about tonight's performances (that is unless someone starts singing Phil Collins, in which case you might just get another crabby report tomorrow).
Any predictions on what songs the contestants will (or should) choose?

subset: commoncrawl


text: HIPPOCAMPUS 16:208–215 (2006) Functional Maturation of Adult-Generated Granule Cells Linda S. Overstreet-Wadiche* and Gary L. Westbrook ABSTRACT: The excitability and connectivity of adult-generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity-dependent regulation. V 2006 Wiley-Liss, Inc. C KEY WORDS: neurogenesis; hippocampus; dentate gyrus; synaptic INTRODUCTION A central question in stem cell biology is understanding how stem cells and their progeny interact with their environment. Adult neurogenesis in the dentate gyrus (DG) provides one model system to investigate this issue. To participate in the hippocampal circuit, adult-generated cells must acquire neuronal functions, such as membrane excitability, and interact with mature neurons to establish synaptic connectivity. Studies of hippocampal progenitors in vitro demonstrate that these processes are influenced by environmental factors (Song et al., 2002a,b). Just as neuronal properties progressively mature during neonatal development, newborn granule cells in adults progress through sequential stages of functional maturation. Recent work suggests that this progression is a dynamic process that can be modulated by differing environmental conditions. In this review, we summarize current understanding of the functional maturation of adult-generated granule cells, with an emphasis on new techniques that allow identification of adult-generated cells at discrete postmitotic ages. PROPERTIES OF IMMATURE GRANULE CELLS DURING NEONATAL DEVELOPMENT Insights into the maturation of adult-generated granule cells can be gleaned from studying granule cell development during the neonatal period. In rodents, granule cell neurogenesis begins between embryonic day 10 and 14, in a narrow area of neuroepithelium adjacent to the fimbria (Angevine, 1965; Schlessinger, 1975; the primary dentate matrix, Altman and Bayer, 1990). Postmitotic immature granule cells and preVollum Institute, L474, Oregon Health & Science University, Portland, Oregon Grant sponsor: NIH Grant number: NS26494. *Correspondence to: Linda Overstreet-Wadiche, Vollum Institute, L474, Oregon Health & Science University, Portland, OR 97239. E-mail: firstname.lastname@example.com Accepted for publication 1 November 2005 DOI 10.1002/hipo.20152 Published online 12 January 2006 in Wiley InterScience (www.interscience. wiley.com). C V 2006 cursors then migrate into the DG. Subsequent generations of granule cells are generated in the secondary matrix and, like adult-generated cells, in the tertiary matrix of the subgranular zone. The granule cell layer (GCL) forms in an outside-in pattern, such that the oldest granule cells are located near the molecular layer and newly born cells are near the subgranular zone. The peak of granule cell neurogenesis occurs in the secondary and tertiary matrix at the end of the first postnatal week and declines over subsequent weeks (Schlessinger et al., 1975). The prolonged window of granule cell neurogenesis means that granule cells at different developmental stages and postmitotic ages coexist within the GCL. Trommer and colleagues took advantage of this intermingling to compare the physiology of individual granule cells at various developmental stages (Liu et al., 1996; Liu et al., 1998; Liu et al., 2000; Ye et al., 2000; Ye et al., 2005). Patch-clamp recordings during the first postnatal month revealed a range of input resistances (IR, a measure of the number of ion channels open at the test membrane potential) and resting membrane potentials (RMP, a function of the nongated ion channels and the concentration gradients of their permeate ions) in neighboring granule cells. IR was inversely correlated with dendrite length, a morphological measure of granule cell maturity (Fig. 1a). Thus, IR could be used, even in the absence of morphological data, as an indicator of granule cell maturity. IR was also correlated with the RMP. Indeed, high IR and depolarized RMP are hallmarks of immature neurons in many embryonic preparations. Unlike most regions where the IR and RMP shift to mature values in parallel with the age of the animal, some dentate granule cells with very immature properties were present at the end of the first postnatal month, suggesting continued neurogenesis. Furthermore, the most mature granule cells at the end of the first postnatal week had the same properties as the most mature cells at the end of the first postnatal month, suggesting that IR and RMP reached their mature values within weeks of final cell division. Synaptic input to granule cells likewise changes dramatically during neonatal development. The major afferent input, the perforant path, arises from pyramidal cells in the entorhinal cortex (EC). The axons of the medial and lateral entorhinal areas are strictly segregated in the middle and outer molecular layer, respectively. These inputs originate at the middle of the first postnatal week (Fricke and Cowan, 1977). At WILEY-LISS, INC. FUNCTIONAL MATURATION OF ADULT-GENERATED GRANULE CELLS 209 FIGURE 1. Immature granule cells identified by IR and morphology. a: Examples of biocytin-filled granule cells with immature, intermediate, and mature IR and morphology in juvenile rats. Arrows indicate labeled axons. Scale bars, 20 mm. Modified with permission from Elsevier: Brain Research 856:202–212, 2000. Characteristic synaptic currents and membrane potential responses (insets) are shown below. Cells with high IR had prominent slow GABAA receptor-mediated currents (asterisk) and small prolonged action potentials (arrowhead). Cells with lower IR and more mature morphology had larger glutamatergic synaptic currents and fast action potentials. Scale bars, 50 pA, 20 ms; 40 mV, 20 ms (insets). Modified with permission from The American Physiological Society: Journal of Neurophysiology 76:1074–1088. b: Granule cells at similar stages of maturation were found in young adult rats. Examples of biocytin-filled cells (green, top panels) and volt- age responses to current injections (middle panels) and synaptic responses to stimulation in the molecular layer (lower panels). Granule cells with the most immature morphology (left panels) either did not fire action potentials or had only small action potentials. These cells lacked synaptic input or had only GABAA receptor-mediated responses (blocked by bicuculline, BMI). Cells with larger dendritic arbors and more mature membrane properties had progressively greater glutamatergic synaptic input, blocked by the AMPA receptor antagonist CNQX, and the NMDA receptor antagonist AP5 (middle and left panels). Scale bars 20 mm (top), 50 ms, 20 mV (middle), and 50 ms, 20 pA (bottom). Modified with permission from Elsevier: Brain Research 1017:21–31, 2004. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.] 210 OVERSTREET-WADICHE AND WESTBROOK 2004). Thus, immature granule cells have a lower threshold for induction of LTP and LTD. Manipulations that enhance neurogenesis, such as exercise, are correlated with greater LTP of population responses (Van Praag et al., 1999; Farmer et al., 2004). Enhanced plasticity in granule cells with immature properties strengthens the idea that enhanced plasticity is causally related to greater numbers of immature granule cells. Reduced numbers of newborn granule cells in irradiated animals was also associated with decreased LTP (Snyder et al., 2001). this time, immature granule cells are already surrounded by a well-developed plexus of GABAergic axons (Lubbers and Frotscher, 1988). Between postnatal day 5 and 12, Ye et al., (2000) found that granule cells could be segregated based on their response to stimulation in the middle molecular layer. Granule cells with the most immature membrane properties had either no synaptic response, exclusively GABAergic synaptic input, or small NMDA receptor-mediated responses. Granule cells with more mature IR and RMP had both AMPA and NMDA-receptor mediated EPSCs. This sequence of synaptogenesis is similar to CA1 pyramidal cells, where GABAergic input appeared before glutamatergic responses that were mediated sequentially by NMDA and then AMPA receptors (Tyzio et al., 1999). However, until postnatal day 4, granule cells had exclusively GABAergic synapses (Hollrigel and Soltesz, 1997). The subsequent appearance of glutamatergic input from the perforant path parallels dendrite elongation and spine formation in the molecular layer at the end of the first postnatal week (Jones et al., 2003). ADULT-GENERATED GRANULE CELLS LABELED WITH RETROVIRAL VECTORS Granule cells with immature membrane properties clearly have distinct physiological behavior compared to granule cells with mature properties. However, identification of adult-generated granule cells exclusively by their immature properties has limitations. For example, it is difficult to assess maturity based on IR and RMP because reported values vary widely, presumably, reflecting both developmental variation and technical differences such as seal resistance. This approach also cannot determine whether adult-generated granule cells retain distinct properties once they have completely matured, nor can it provide information about the postmitotic age of immature cells. Labeling dividing cells with retroviral vectors that express green fluorescent protein (GFP; Lewis and Emerman, 1994) is one way to address these issues. Once incorporated into progenitors during mitosis, subsequent newborn cells express GFP and can be visualized in living preparations. van Praag et al. (2002) used this technique to prove that adult-generated granule cells can become integrated into the hippocampal circuit. Four to eight weeks after viral injections, labeled granule cells had similar membrane and synaptic properties as unlabeled mature cells (Fig. 2a). By 4 months, labeled adult-generated granule cells also achieved dendrite complexity and spine number comparable to mature granule cells. These results support the view that, given sufficient time, adult-generated granule cells become indistinguishable from neonatal-generated cells. However, more subtle measures, such long term plasticity, have not yet been compared. Retroviral labeling in organotypic slice cultures revealed various phenotypes of stem cell progeny, including early and late stages of differentiating neurons, as well as GFAP- and nestin-expressing progenitors (Kamada et al., 2004). Studies using viral labeling to identify adult-generated granule cells after various time windows will certainly provide valuable information about their physiology and progression of maturation (Esposito et al., 2005). In addition, this approach can be used to genetically alter adult-generated cells to study the molecular mechanisms of their development (Tashiro et al., 2004; Ge et al., 2005). IMMATURE GRANULE CELLS IN THE ADULT DG Immature granule cells in adult animals can also be identified by similar membrane properties and morphology. Ambrogini et al. (2004) classified granule cells in young adults based on their responses to perforant path stimulation (Fig. 1b). Similar to neonates, granule cells with the most immature membrane properties had either no synaptic input or exclusively GABAergic synaptic input. Granule cells with progressively more mature membrane properties and morphology also had glutamatergic synaptic responses. Immature granule cells were located exclusively near the border of the subgranular zone, whereas more mature cells were scattered throughout the GCL. Wang et al. (2000) also reported morphological and physiological differences between granule cells located in the inner and outer GCL. Although they had mature IR, granule cells in the inner GCL had more compact dendritic arbors and fewer primary branches compared to those in the outer CGL. Both populations had perforant path input, but interestingly, plasticity of synaptic transmission differed between the two groups. Granule cells in the inner GCL had greater paired-pulse facilitation, a measure of release probability. They also displayed long-term potentiation (LTP) whereas LTP in granule cells of the outer-layer only occurred when GABAergic inhibition was blocked (Wang et al., 2000). Schmidt-Hieber et al. (2004) showed that granule cells identified by their immature membrane properties and morphology had a lower threshold for LTP induced by u-burst stimulation. This may involve Ca2þ spikes mediated by T-type channels (Ambrogini et al., 2004; Schmidt-Hieber et al., 2004), that could promote LTP by enhancing postsynaptic Ca2þ entry and relief of the Mg2þ block of NMDA receptors. Pairing EPSPs with subthreshold Ca2þ spikes also resulted in long-term depression (LTD) in immature, but not mature, granule cells (Bischofberger et al., PROPERTIES OF NESTIN-EGFP PROGENITORS Adult-generated cells can also be identified using fluorescent markers expressed under transcriptional control of developmen- FUNCTIONAL MATURATION OF ADULT-GENERATED GRANULE CELLS 211 currents and in some cases, voltage gated Naþ currents. Some Type II cells also fired action potentials and displayed spontaneous GABAergic synaptic currents (Tozuka et al., 2005; Wang et al., 2005). Type II cells likely constitute a group of highly proliferative ''transient amplifying cells'' that can further be divided based upon sequential marker expression (Kronenberg et al., 2003). PROPERTIES OF POMC-EGFP NEWBORN GRANULE CELLS It has been proposed that an important milestone of granule cell development is the transient postmitotic stage (stage 5; Kemperman et al., 2004). Newborn granule cells in which the proopiomelanocortin (POMC) promoter drives EGFP appear to be at this critical junction. POMC, a pro-hormone that regulates feeding and energy homeostasis, is normally expressed in the pituitary and hypothalamus. Transgenic POMC-EGFP mice had EGFP expression colocalized with POMC peptides in those brain regions (Young et al., 1998). However, several independent lines of mice also had expression in the DG that was not correlated with POMC mRNA or protein (Overstreet et al., 2004b). Dentate expression required cryptic promoter sequences distinct from those required for expression in POMCproducing cells of the pituitary. Thus, POMC-EGFP in the DG appears unrelated to expression of the POMC gene product. However, several lines of evidence indicated POMC-EGFP was expressed by newborn granule cells. First, labeled cells had the morphology of newborn granule cells with small cell bodies located near the border of the hilus and granule cell layer. They had a primary dendrite that branched within the inner molecular layer but did not extend through the middle and outer molecular layers. They had basal neurites, and their axons projected through the hilus to stratum lucidum of CA3. They did not have mature mossy fiber boutons but rather their axons were studded with many small diameter varicosities. Second, EGFP-labeled cells had membrane properties consistent with immature neurons (Fig. 2). They had a high IR ($8 G X) and depolarized RMP. They fired small and broad action potentials mediated by Naþ channels, characteristic of immature neurons. Third, they expressed markers of immature granule cells such as PSA-nCAM, but they lacked GFAP immunoreactivity. Fourth, they showed transient colabeling with BrdU. Finally, the number of EGFP-labeled cells declined with age and was enhanced by exercise, parallel to age- and exercise-induced changes in neurogenesis. The timing of POMC-EGFP expression can be compared to the expression of various developmentally-regulated proteins that are used to define stages of neural stem cell maturation (Fig. 3a). For example, pulse-chase experiments with a single injection of BrdU showed that dividing precursors express nestin and doublecortin (Brown et al., 2003; Fukuda et al., 2003). Doublecortin expression continues for weeks, overlapping with other immature markers such as PSA-nCAM and bIII tubulin. Conversely, NeuN colabeling was detected 10 days after BrdU incorporation, and gradually increased until >85% of BrdUþ FIGURE 2. Adult-generated granule cells identified with viral and genetic labeling. a: An example of an adult-generated granule cell expressing GFP (green) 4 weeks after injection of a retroviral vector. Four to eight weeks after labeling, adult-generated granule cells had dendrites that extended through the molecular layer and they received excitatory input from the perforant path. Current injection (Im, lower panel) revealed labeled granule cells had mature membrane properties, including low input resistance and large action potentials. Scale bars, 50 ms, 25 mV. Modified with permission from Macmillan Publishers Ltd: Nature 415:1030– 1034, 2002. b: In POMC–EGFP transgenic mice, EGFP is expressed in newborn granule cells (green) with immature properties. Compared to mature granule cells filled with biocytin (red) or 4week-old adult-generated granule cells (a), POMC–EGFP granule cells had short dendrites and small cell bodies. The arrow points to an EGFP-labeled cell filled with biocytin. Scale bar, 50 mm. POMC–EGFP cells had high IR and small prolonged action potentials (lower panel). GCL, granule cell layer; IML, inner molecular layer. Modified from The Society for Neuroscience: The Journal of Neuroscience 24:3251–3259, 2004. [Color figure can be viewed in the online issue, which is available at www.interscience. wiley.com.] tally-regulated promoters. This enables reliable, although transient, labeling of an entire population of adult-generated cells. GFP expressed by neural-specific regions of the nestin promoter is one such example (Yamaguchi et al., 2000). Interestingly, the morphology and membrane properties of nestin-GFP cells indicated at least two functional populations (Filippov et al., 2003; Fukuda et al., 2003; ). Type 1 cells were radial glial cells with stem-cell neurogenic potential (see also Seri et al., 2001). These cells expressed the glial marker GFAP and had astrocytic properties including low input resistance, a relatively linear currentvoltage relationship, A-type potassium currents, and a resting potential near the Kþ equilibrium potential. The second population of nestin-GFP cells lacked GFAP expression and astrocytic properties. Rather, these type II cells were smaller and had high input resistance, rapidly inactivating voltage gated Kþ 212 OVERSTREET-WADICHE AND WESTBROOK ture granule cells identified by IR and cell morphology (Liu et al., 2000; Ye et al., 2000; Ambrogini et al., 2004). POMC– EGFP cells had the same properties in adults and neonates, indicating that EGFP marks newborn granule cells at the same functional stage regardless of the age of the mouse. POMCEGFP expression also provides information about the timing of granule cell maturation. For example, the lack of excitatory input indicates it takes at least 2 weeks for the majority of adult-generated granule cells to receive input from the perforant path. This is consistent with the appearance of dendritic spines at 2–3 weeks after viral labeling (Zhao et al., 2004; Esposito et al., 2005). The initial appearance of GABAergic synapses on newborn granule cells is consistent with a putative trophic role for GABA in development (Owens and Kriegstein, 2002). During the first postnatal week, granule cells have GABAergic synaptic input with slow kinetics (Hollrigel and Soltesz, 1997) and depolarized reversal potentials (Hollrigel et al., 1998). Similarly, in neonates and adults, synaptic currents in POMC–EGFP labeled granule cells had slow kinetics, presumably due to the absence of the a1 GABAA receptor subunit (OverstreetWadiche et al., 2005). Slow, depolarizing GABA-mediated synaptic responses may promote Ca2þ entry via voltage-gated Ca2þ channels. Consistent with this idea, the ClÀ reversal potential in newborn granule cells was $30 mV more positive than in neighboring mature cells (À45 mV compared to À75 mV; Overstreet et al., 2005), in the range of Ca2þ channel activation (Schmidt-Hieber et al., 2004). Because the action potential threshold in newborn cells was still more depolarized ($38 mV), GABA receptor activation usually did not drive firing but rather shunted action potentials induced by current injection. In this sense, GABAergic responses were depolarizing but not necessarily excitatory (Staley and Mody, 1992). Although the measured RMP of newborn cells in whole-cell recording was also near the ClÀ reversal potential, such measurements are likely artificially low due to current leak through the pipette seal (Barry and Lynch, 1991). The appearance of spontaneous Ca2þ influx blocked by GABAA receptor antagonists (unpublished observations) strongly suggests that newborn granule cells have depolarizing GABAergic synaptic responses that activate voltage-gated Ca2þ channels. FIGURE 3. POMC–EGFP is selective for newborn granule cells. a: The temporal expression pattern of developmentally regulated markers in adult-generated granule cells can be determined by colabeling with BrdU at multiple time intervals. Nestin and doublecortin (DCX) are expressed by neural progenitors and in the case of doublecortin, by newborn postmitotic neurons. The mature granule cell marker NeuN is subsequently expressed. NeuN and doublecortin data are from Brown et al., 2003; Nestin data is from Fukuda et al., 2003. The POMC–EGFP expression profile indicates it is selective for newborn granule cells that are nearly 2 weeks postmitotic. Consistent with this timing, POMC–EGFP labeled cells did not express nestin (b), or high levels of NeuN (c). However, EGFP-labeled newborn granule cells expressed doublecortin (d). [Color figure can be viewed in the online issue, which is available at www.interscience. wiley.com.] cells expressed this marker for mature granule cells (Brown et al., 2003). The temporal pattern of POMC-EGFP expression reveals that it is selective for immature, but differentiated, neurons. In adults, peak colabeling between BrdU and EGFP occurred at 12 days and declined before 30 days (Overstreet et al., 2004a,b). The absence of BrdU colabeling at short (<3 days) and longer (30 days) intervals indicates that labeled cells are not dividing precursors nor mature granule cells. Consistent with this idea, POMC-EGFP granule cells did not express nestin nor significant levels of NeuN, but they did express doublecortin (Fig. 3b–d). The uniform membrane properties of POMC–EGFP granule cells further indicate they constitute a relatively narrow developmental stage defined by their functional characteristics. At this stage, newborn granule cells expressed glutamate receptors, but they lacked MPP synaptic input, likely because their short dendrites did not extend through the middle molecular layer. However, they were surrounded by a dense network of GABAergic boutons and they received GABAergic synaptic input (Overstreet et al., 2004b; Overstreet-Wadiche et al., 2005). Thus they are similar to the physiologically most imma- THE TIMING OF ADULT-GENERATED GRANULE CELL FUNCTIONAL MATURATION A working model for the progression of granule cell maturation can be generated by synthesizing the results described earlier with studies of BrdU labeling and marker expression (Fig. 4). Some interesting, and perhaps unexpected, developmental patterns emerge. For example, the IR of neural stem cells is initially very low (<100 MX), typical of astrocytes with high Kþ permeability. This rapidly changes as asymmetrical cell division generates much smaller transiently-amplifying cells followed by newborn granule cells with a > 10-fold higher IR. Over the next 2 months, the IR gradually approaches the value expected of FUNCTIONAL MATURATION OF ADULT-GENERATED GRANULE CELLS 213 FIGURE 4. Functional maturation of adult-generated granule cells. Stages of granule cell maturation based on functional studies. Information about the timing of each stage was provided by the complementary techniques of retroviral and genetic labeling. Labeling with developmentally regulated promoters (nestin-GFP, POMC– EGFP) provides timing information for an entire population of cells. This allows the average age of the population to be determined, but the precise age of any individual cell is unknown. Conversely, viral labeling places a precise upper age limit on individual cells, but fewer cells are labeled. The lack of age information for immature granule cells identified by their immature membrane properties is indicated by a (?). Asterisks indicate data for four- to eight-week-old granule cells from van Praag et al. (2002). The timing of granule cell maturation might be altered by conditions including exercise, seizures, and aging. Very recent studies with retroviral labeling corroborate this sequence of granule cell integration (Esposito et al., 2005; Ge et al., 2005). [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.] mature granule cells ($300 MX). Proliferation and differentiation of several cell types is regulated by the expression of specific subtypes of Kþ channels (Kotecha and Schlichter, 1999; Cahalan et al., 2001; Chittajallu et al., 2002), but it is unknown whether similar mechanisms regulate dentate progenitors. The data also suggest that various aspects of neuronal function reach maturity at different times. For example, $2 week old granule cells that express POMC–EGFP have immature action potentials that rapidly mature as glutamatergic input arises over the next weeks (Ge et al., 2005). However, glutamatergic synapses on immature granule cells could exhibit enhanced synaptic plasticity for many subsequent weeks. Similarly, some newborn neurons have mature IR and RMP by 4 weeks, but spine growth and dendritic complexity increase for at least 8 weeks (van Praag et al., 2002). Although newly generated mossy fiber axons reach CA3 in the early weeks of granule cell genesis (Hastings and Gould, 1999; Overstreet et al., 2004b), nothing is known about the maturation of granule cell output. PLASTICITY OF GRANULE CELL FUNCTIONAL MATURATION The step-wise progression of granule cell development provides many points where maturation could be modulated. Indeed, studies using marker expression suggest that maturation is altered by conditions including exercise, seizures, and aging (e.g., Brandt et al., 2003; Kronenberg et al., 2003; Rao et al., 2005). POMC–EGFP expression is prolonged in adults compared to neonates, suggesting this functional stage is delayed in the adult environment that lacks the neonatal patterns of depolarizing network activity (Overstreet et al., 2004a). Pathological conditions can also alter the rate of granule cell maturation. After pilocarpine-induced seizures, POMC–EGFP labeled granule cells have elongated dendrites and they receive excitatory input (Bromberg et al., 2004). These results suggest that the functional integration, as well as proliferation (Deisseroth et al., 2004), of newborn granule cells is sensitive to activity in the 214 OVERSTREET-WADICHE AND WESTBROOK pocampus shows electrophysiological and morphological characteristics of astrocytes. Mol Cell Neurosci 23:373–382. Fricke R, Cowan WM. 1977. An autoradiographic study of the development of the entorhinal and commissural afferents to the dentate gyrus of the rat. J Comp Neurol 173:231–250. Fukuda S, Kato F, Tozuka Y, Yamaguchi M, Miyamoto Y, Hisatsune T. 2003. Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus. J Neurosci 23:9357–9366. Ge S, Goh EL, Sailor KA, Kitabatake V, Ming GL, Song H. 2005. GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature December 11 [epub ahead of print]. Hastings NB, Gould E. 1999. Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol 413:146– 154. Hollrigel GS, Soltesz I. 1997. Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus. J Neurosci 17:5119–5128. Hollrigel GS, Ross ST, Soltesz I. 1998. Temporal patterns and depolarizing actions of spontaneous GABAA receptor activation in granule cells of the early postnatal dentate gyrus. J Neurophysiol 80: 2340–2351. Jones SP, Rahimi O, O'Boyle MP, Diaz DL, Claiborne BJ. 2003. Maturation of granule cell dendrites after mossy fiber arrival in hippocampal field CA3. Hippocampus 13:413–27. Kamada M, Li RY, Hashimoto M, Kakuda M, Okada H, Koyanagi Y, Ishizuka T, Yawo H. 2004. Intrinsic and spontaneous neurogenesis in the postnatal slice culture of rat hippocampus. Eur J Neurosci 20: 2499–508. Kempermann G, Jessberger S, Steiner B, Kronenberg G. 2004. Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447–52. Kotecha SA, Schlichter LC. 1999. A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation. J Neurosci 9:10680–10693. Kronenberg G, Reuter K, Steiner B, Brandt MD, Jessberger S, Yamaguchi M, Kempermann G. 2003. Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli. J Comp Neurol 467:455–463. Lewis PF, Emerman M. 1994. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J Virol 68:510–516. Liu X, Tilwalli S, Ye G, Lio PA, Pasternak JF, Trommer BL. 2000. Morphologic and electrophysiologic maturation in developing dentate gyrus granule cells. Brain Res 856:202–212. Liu YB, Lio PA, Pasternak JF, Trommer BL. 1996. Developmental changes in membrane properties and postsynaptic currents of granule cells in rat dentate gyrus. J Neurophysiol 76:1074–1088. Liu YB, Ye GL, Liu XS, Pasternak JF, Trommer BL. 1998. GABAA currents in immature dentate gyrus granule cells. J Neurophysiol 80: 2255–2267. Lubbers K, Frotscher M. 1988. Differentiation of granule cells in relation to GABAergic neurons in the rat fascia dentata. Combined Golgi/EM and immunocytochemical studies. Anat Embryol (Berl) 178:119–127. Moody WJ, Bosma MM. 2005. Ion channel development, spontaneous activity, and activity-dependent development in nerve and muscle cells. Physiol Rev 85:883–941. Overstreet LS, Bensen AL, Westbrook GL. 2004a. Delayed development of adult-generated granule cells. Soc Neurosci Abstr. 155.6. Overstreet LS, Hentges ST, Bumaschny VF, de Souza FS, Smart JL, Santangelo AM, Low MJ, Westbrook GL, Rubinstein M. 2004b. A transgenic marker for newly born granule cells in dentate gyrus. J Neurosci 24:3251–3259. Overstreet-Wadiche LS, Bromberg DA, Bensen AL, Westbrook GL. 2005. GABAergic Signaling to Newborn Neurons in Dentate Gyrus. J Neurophysiol 94:4528–4532. local environment. Mechanisms underlying activity-dependence are just beginning to emerge. For example, depolarizing GABAergic inputs contribute to activity-dependent differentiation and maturation (Tozuka et al., 2005; Ge et al., 2005). Many activity-dependent processes involved in neuronal maturation and synaptogenesis during neonatal development (Moody and Bosma, 2005) are also likely regulators of neuronal maturation in adults. Acknowledgments We thank Bryan Luikart for comments on the manuscript. G.L.W. is supported by NIH (NS26494). REFERENCES Altman J, Bayer SA. 1990. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods. J Comp Neurol 301:365–381. Ambrogini P, Lattanzi D, Ciuffoli S, Agostini D, Bertini L, Stocchi V, Santi S, Cuppini R. 2004. Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus. Brain Res 1017:21–31. Angevine JB, Jr. 1965. Time of neuron origin in the hippocampal region. An autoradiographic study in the mouse. Exp Neurol Suppl 2:1–70. Barry PH, Lynch JW. 1991. Liquid junction potentials and small cell effects in patch-clamp analysis. J Membr Biol 121:101–117. Bischofberger J, Schmidt-Hieber C, Jonas P. 2004. Ca2þ spikes and bidirectional synaptic plasticity in young hippocampal granule cells. Soc Neurosci Abstr56.15. Brandt MD, Jessberger S, Steiner B, Kronenberg G, Reuter K, BickSander A, von der Behrens W, Kempermann G. 2003. Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice. Mol Cell Neurosci 24:603–613. Bromberg D, Overstreet LS, Westbrook GL. 2004. Seizures accelerate functional integration of newly born granule neurons. Soc Neurosci Abstr611.11. Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG. 2003. Transient expression of doublecortin during adult neurogenesis. J Comp Neurol 467:1–10. Cahalan MD, Wulff H, Chandy K. 2001. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol 21:235–252. Chittajallu R, Chen Y, Wang H, Yuan X, Ghiani CA, Heckman T, McBain CJ, Gallo V. 2002. Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle. Proc Natl Acad Sci 99:2350–2355. Deisseroth K, Singla S, Toda H, Monje M, Palmer TD, Malenka RC. 2004. Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron 42:535–52. Esposito MS, Piatti VC, Laplagne DA, Morgenstern NA, Ferrari CC, Pitossi FJ, Schinder AF. 2005. Neuronal differentiation in the adult hippocampus recapitulates embryonic development. J Neurosci 25:10074–10086. Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. 2004. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience 124:71–79. Filippov V, Kronenberg G, Pivneva T, Reuter K, Steiner B, Wang LP, Yamaguchi M, Kettenmann H, Kempermann G. 2003. Subpopulation of nestin-expressing progenitor cells in the adult murine hip- FUNCTIONAL MATURATION OF ADULT-GENERATED GRANULE CELLS Owens DF, Kriegstein AR. 2002. Is there more to GABA than synaptic inhibition? Nat Rev Neurosci 3:715–727. Rao MS, Hattiangady B, Abdel-Rahman A, Stanley DP, Shetty AK. 2005. Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation. Eur J Neurosci 21:464–476. Schlessinger AR, Cowan WM, Gottlieb DI. 1975. An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the rat. J Comp Neurol 159: 149–175. Schmidt-Hieber C, Jonas P, Bischofberger J. 2004. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature 429:184–187. Seri B, Garcia-Verdugo JM, McEwen BS, Alvarez-Buylla A. 2001. Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci 21:7153–7160. Snyder JS, Kee N, Wojtowicz JM. 2001. Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J Neurophysiol 85: 2423–2431. Song H, Stevens CF, Gage FH. 2002a. Astroglia induce neurogenesis from adult neural stem cells. Nature 417:39–44. Song HJ, Stevens CF, Gage FH. 2002b. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci 5:438–445. Staley KJ, Mody I. 1992. Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol 68:197–212. Tashiro A, Zhao C, Gage FH. 2004. Retrovirus-mediated gene knockout techniques in adult newborn neurons. Soc Neurosci Abs607.7. Tozuka Y, Fukuda S, Namba T, Seki T, Hisatsune T. 2005. GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. Neuron 47:803–815. 215 Tyzio R, Represa A, Jorquera I, Ben-Ari Y, Gozlan H, Aniksztejn L. 1999. The establishment of GABAergic and glutamatergic synapses on CA1 pyramidal neurons is sequential and correlates with the development of the apical dendrite. J Neurosci 19:10372–10382. van Praag H, Christie BR, Sejnowski TJ, Gage FH. 1999. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427–13431. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. 2002. Functional neurogenesis in the adult hippocampus. Nature 415:1030–1034. Wang LP, Kempermann G, Kettenmann H. 2005. A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input. Mol Cell Neurosci 29:181–189. Wang S, Scott BW, Wojtowicz JM. 2000. Heterogenous properties of dentate granule neurons in the adult rat. J Neurobiol 42:248–257. Yamaguchi M, Saito H, Suzuki M, Mori K. 2000. Visualization of neurogenesis in the central nervous system using nestin promoterGFP transgenic mice. Neuroreport 11:1991–1996. Ye GL, Song Liu X, Pasternak JF, Trommer BL. 2000. Maturation of glutamatergic neurotransmission in dentate gyrus granule cells. Brain Res Dev Brain Res 124:33–42. Ye GL, Yi S, Gamkrelidze G, Pasternak JF, Trommer BL. 2005. AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells. Brain Res Dev Brain Res 155:26–32. Young JI, Otero V, Cerdan MG, Falzone TL, Chan EC, Low MJ, Rubinstein M. 1998. Cell-specific and developmentally regulated expression of proopiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. J Neurosci 18: 6631–6640. Zhao C, Tashiro A, Ming G-l, Gage FH. 2004. The maturation of newborn granule neurons in the adult mouse hippocampus. Soc Neurosci Abstr.607.18.


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Royal Institution rules out selling Mayfair HQ after reducing its debt
27 Aug 2014
The Royal Institution, the science communication charity, has said it will not have to sell its London...
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Cancer Research UK has announced that it is developing a new smartphone app that will provide more services, including donations, than its current app on a greater range of devices.
Due to launch by the end of March, the app will operate on iPhone, Blackberry, Android and Windows 7 and deliver a variety of content to users including information about the disease, the location of its charity shops and information about the charity's fundraising events.
Users will also be able to set up one-off and regular donations using the app and later versions of the app are set to include a Cancer Research UK shop where users will be able to buy items such as clothing.
Michael Docherty, head of online marketing at Cancer Research UK said: "An app that makes donating quick and easy offers us a great opportunity to grow our income and with more developments in the pipeline, we look forward to offering our supporters one simple and convenient way to donate, fundraise and find out more about our life-saving work."
Users of the new app, developed by Corethree, will also be able to access the Core service portal app where they can buy things like train and bus tickets. They will have the option to round-up the price of the item with the difference going to the charity.
Last May the charity launched a Signs and Symptoms app for iPhone and Android to raise awareness of the early signs of cancer. Cancer Research UK said that for the time being Signs and Symptoms would remain as a separate app, although some of its content will be included in the new app.
For an overview of how charities have been using mobile apps have visit the civilsociety.co.uk apps blog.
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Barclays cashless mobile payment app could be fundraising tool
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27 Aug 2014
The Royal Institution, the science communication charity, has said it will not have to sell its London...
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Social investment organisations will be celebrated in a new awards ceremony announced today by the Cabinet...
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Full Stringer Realty2400 Avenue I, Bay City, TX 77414
(979) 244-4663
Full Stringer Realty is a full service real estate company eager and capable of assisting you in achieving your dream of owning property in or near the Texas Gulf Coast, particularly Bay City, Matagorda, Palacios & Sargent. Honesty and integrity are the heart and soul of Full Stringer Realty. Our goal is to make sure you achieve your real estate dreams. We know and love the coastal area and Full Stringer's agents are the Gulf Coast real estate professionals. Our alliances with the fishing industry and the tourist trade are strong. Full Stringer Realty also owns and operates the Full Stringer Lodge, a full service lodging establishment in Matagorda and Full Stringer Rentals for all your vacation needs.


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Utica Weather
Current Temp 61.0 °F
Wind : Southeast at 8.1 MPH (7 KT)
Humidity : 84 %
Pressure : 1022.3 mb
Heart Run & Walk Shuttle Services
UTICA, N.Y. (WKTV) - Due to limited parking at Utica College, Heart Run & Walk participants are asked to park at the following locations and take shuttle transportation provided at each sight.
Friday, February 28
Saturday, March 1
*Shuttle services begin at 6:00 a.m. on Saturday. Officials say to allow one hour from parking lot to the event.
For mor information, call (315) 266-5403.
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Heritage Bay Condo Rental Photos and Description
Condo, 2 Bedrooms + Convertible bed(s), 2 Baths, (Sleeps 4-8)
With this 2 bedroom 2-bath condo in the upscale gated Heritage Bay golf community, you can receive full membership privileges during your stay and enjoy outstanding golf and tennis at low member rates. The tastefully-decorated and comfortable condo was completed in October 2009. It has all the features you would expect in a high-end residence.
-King bed in master, queen bed in guest room, and two queen sleeper sofas
-Stainless steel appliances
-Corian countertops
-Washer & dryer in the unit
-Three flat-panel TV's with an HD/DVR box and two DVD's
-Wireless Internet access
-18" tile floors with carpeted bedrooms
The condo's lanai offers a gorgeous view of the Lewis/Azinger-designed championship golf course's 14th green and the 15th tee across a beautiful lake. A satellite pool is located directly in front of the condo. The luxurious 27,000 sq ft. Heritage Bay clubhouse boasts great locker-room facilities as well as a billiards room, pro shop, aqua range, grill room and full-service restaurant. Heritage Bay also has outstanding tennis facilities, a spa, fitness center and pool/hot tub with a pool-side Chickie hut. Full membership privileges are available for modest one-time fee.
Heritage Bay offers seclusion, but with convenient access to all that the Naples area offers. Just 4.5 miles off I-75, Heritage Bay is just 20 minutes from the Southwest Florida airport (RSW), 15 minutes from Naples' fabulous gulf coast beaches, and the famous Old Naples/Fifth Avenue area. Outlet malls, grocery stores, and other great shopping is only minutes away.
Keywords: Condominium
- Suitability:
- non smoking only
A professional couple that tires of the long and cold Ohio winters, we enjoy the sunny gulf area for extended summertime activities offered by the Naples area.
We were very impressed by the beauty of the Naples area and access to the beaches and great golf courses. Heritage Bay offers convenient access to everything that a Snowbird could want: golf, beaches, sun, and great seafood at an affordable price.
Our condo has terrific views and easy access to swimming pools, golf, bike/walking trails, spa, fitness center, tennis, and restaurants without ever leaving the property. You can choose to enjoy quiet relaxation or mingle with the other friendly residents at the nearby pool. Tenants can also enjoy full membership privileges with a modest one-time fee. This would include unlimited golf for a cart fee only. The condo's furnishings are high-quality and is tastefully and comfortably decorated.


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This Chilling Video Is Guaranteed to Make You Stop Speeding
We all know speeding is a giant no-no, but if you need a reminder, here's a sobering one.
Watch Things That Look Amazing in Slow Motion
We love a good water balloon to the face. However, we've never seen a water balloon to the face that looked quite so exquisitely gorgeous. Watch this and more things is beautiful slow motion.
62 Seconds of People Having Trouble Rollerblading
Rollerblading is tough. It's good exercise, sure, but who didn't fall the first time they put on the blades? You? Yeah, right. So give these folks a break already.
67 Seconds of People Eating Habanero Peppers [Video]
Habanero peppers are some of the spiciest foods on the planet, so of course people like to film themselves trying to eat them.
Adorable Dog Goes Bananas on a Leaf Blower
Does this dog have a split personality? It sure looks like he might.
Watch These Cats and Dogs Who Really Hate Taking Baths
If you've ever tried to give a cat a bath—or even just bring the cat anywhere near a bathtub—then you know how these people feel.
Watch These People Cutting Down Trees Wrong
Tree-cutting is a dangerous activity, one best left to professionals. But these folks don't care.
Watch These People Using the Grill Wrong
It's time for a refresher on what exactly not to do with your grill.
See Adults Trying to Ride Kids' Toys
It sure is fun to ride a big wheel; any 5-year-old can tell you that. But when a grownup tries to do it? Well ...
Watch People Getting Nailed by Huge Waves
Beach season has begun, so it's time to remind everyone that oceans are powerful forces of nature.


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By kukur
via theprofessionalspoint.blogspot.in
Submitted: Jan 10 2014 / 21:00
Apache CouchDB and CouchBase, both are Free, Open Source, NoSQL document databases using JSON as their document format. Apache CouchDB and CouchBase have a lot of similarities and differences. Basically CouchBase is made up by combining the features of CouchDB and MemBase databases. CouchDB's document-oriented data model, indexing and querying capabilities are combined with MemBase's distributed key-value data model, high performance, easily scalable, always-on capabilities are combined to form CouchBase.
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The River Wey is one of Surrey's best kept secrets. Today the 20 mile navigable stretch of the river and its 16 locks, are owned and maintained by The National Trust. The River Wey holds both surprises and untold stories round every bend, it offers people the chance to experience and see the lovely countryside of Surrey from a completely different direction. A narrow boat holiday provides holiday makers of all ages and with any level of experience to relax and unwind from everyday life. When will you make your own mark on the River Wey? Holidays on the River Wey run ...
We began our weekend cruise along the lovely Kennet & Avon Canal from the pretty town of Bradford on Avon, next to the lock. We were staying and cruising on the Princess 2, which was perfect for just the two of us, plus our two dogs. The Princess 2 has a 'reverse' layout, which means that the kitchen and saloon area is at the back of the boat rather than the front, making it easier to get drinks or snacks when required without completely deserting the person who is steering the boat. The Princess 2 also had a very comfortable ...
'Serenity' is a luxury widebeam boat sleeping four, available for self-hire holidays on the Grand Union Canal in Bedfordshire. This widebeam is fully equipped with top-notch gadgets including flat screen TV's in the bedroom and saloon (with Freeview), wine cooler in the galley, DVD Players and a DAB Radio/CD player with iPod dock and USB port. You will also find playing cards, Monopoly and Scrabble on board for afternoon entertainment when spending an evening in. This widebeam has been built in a 'reverse' layout, which refers to the kitchen and living room area being at the back of the boat. This ...
Britain's largest protected wetland, the Norfolk and Suffolk Broads offers over 125 miles of lock-free cruising. Broadland attractions include plentiful waterside eateries, market towns, villages and many pleasant walks. Hire a boat from Horning on the Norfolk Broads and enjoy a relaxing boating holiday afloat with the family this Easter. There are so many attractions to visit on the waterfront, suitable for all the family you will be spoilt for choice! Four berth Copper Emblem is currently available throughout the Easter Holidays, suitable for family groups with a double and 2 single beds. The weekly hire charge is £698.00 or for a ...
2014 Unique Long Term Cruising Opportunity! If you fancy taking 3 months or more to explore the UK's fabulous historic canal system, we are now offering 70 foot 'Lillian Ginger' for extended cruising at a cost of just £1,295 per month (minimum hire 3 months). Cost excludes fuel (depart with full tank and pay for top up on return, first 2 gas bottles supplied). 3 sets of bed linen supplied. Perfect for 1 or 2 couples as she offers 2 double bedrooms each with its own bathroom. Call 01252 796400 for more information and bookings. Available for long term hire from ...
Available for 2014 holiday hire on our website is four berth vintage cruiser, 'C'est La Vie.' Hire this classic boat and experience a holiday on one of the few remaining mahogany trimmed cruisers, a high end boat built in 1967 with a stylish interior reminiscent of times past. The boat sleeps four in comfort, with either one double and two singles or four singles, perfect for family groups or friends looking to return to the Norfolk Broads on a boating holiday. It has a fully equipped galley and a sliding roof to admire the Norfolk Broads in the open air. [caption ...
A short break from Stretton under Fosse to Braunston: Arrive at the Stretton under Fosse marina and receive your detailed show through of the boat to make sure you are comfortable with your hire boat. Once you feel comfortable operating your narrowboat, cruise south on the North Oxford Canal, meandering through the woodlands before reaching Newbold Tunnel at Newbold on Avon. After navigating your way through the 250yd long tunnel, you may want to take a break at one of the two pubs located along the moorings here. Leaving behind Newbold, pass over the two aqueducts on the outskirts of Rugby, where ...
Hire a canal boat on the Kennet and Avon Canal and cruise to Bath on a traditional narrowboat, a relaxing break ideal for novices. Select your favourite narrowboat from either Bradford on Avon, Hilperton or Bath and explore the historical city of Bath including the iconic architecture, Roman Bath Spa's and shopping facilities. [caption id="attachment_4228" align="aligncenter" width="479"] Canal boat holidays to Bath[/caption] An ideal short break to Bath City Centre on a boating holiday Hire a canal boat from Bradford on Avon or Hilperton and cruise to Bath City Centre on a traditional narrowboat holiday. Day 1: Upon arriving at the marina in the afternoon, ...
'Lutra', a traditional sailing yacht, has been introduced to the Norfolk Broads for the 2013 Autumn season. She is ideal for experienced sailors looking to holiday on the Norfolk Broads, offering an excellent sailing performance as well as providing a comfortable stay for holiday hirers. Perfect for small family groups or couples, Lutra sleeps up to four people comfortably, with a fully equipped galley and a spacious light interior. On-board Lutra is well equipped with: warm air heating hot water fridge Two burner cooker, grill and oven Spacious shower Duvets Diesel engine for quiet cruising [caption id="attachment_4186" align="aligncenter" width="408"] Traditional sailing yacht, 'Lutra'[/caption] Lutra is available to hire from the ...
Trudi, part of our team here at Waterways Holidays has been gracious enough to write up her experiences of the Worcester & Birmingham Canal and Birmingham Navigations: Beginning our holiday at Stoke Prior near Bromsgrove on the brand new 'Princess 4' narrowboat, our trip to Autherley - on the junction between the Shropshire Union Canal and the Staffordshire and Worcester Canal - began by travelling East towards the lengthy 'Tardebigge flight' (which also makes up part of both the Stourport Ring and the Avon Ring). We had just four crew in total: Me, Captain Ken, our good friend Bob and our ...
Just introduced to Waterways Holidays 2013 availability are four brand new sports and sedan cruisers located at Brundall on the River Yare, near Norwich on the Norfolk Broads.
'Cadet' is a perfect boat for couples with a fixed double cabin in the bow. This cruiser has a very contemporary feel, it is decorated to a high standard with a stylish light wood interior. There is a media centre with MP3 connectivity, flat screen TV and DVD player. Other mod cons include a bow thruster for easy manoeuvring, 240 volts and shore power hook up.
'Captain' is ideal for small families or two couples with a fixed walk around double cabin and optional dinette double in the saloon. This modern cruiser offers a spacious contemporary saloon, with glass bi folding doors accessing the large rear sundeck with seating. Perfect for dining alfresco on those warm summer evenings and offering picturesque views of the Norfolk Broads whilst cruising.
Click to search all our boating holidays on the Norfolk Broads.
Last minute saver! Enjoy a saving of £244.00 on a seven night holiday on four berth narrowboat 'Bath'. Located at Bradford on Avon on the Kennet and Avon Canal, the base is ideally situated for a cruise into the city of Bath – a World Heritage Site. Explore the Abbey, browse the high street shops and independant boutiques and relax in the famous Bath Spas.
Offer applies to holidays starting between the 22nd February and 8th March 2013. Available at an all inclusive price of £675.00, a perfect last minute getaway.
Click to search all our discounted boating holidays or all of our Southern England canal boat holidays
We are offering 40% off boating holidays from Clifton on Dunsmore on the North Oxford Canal. Ideally located to offer a variety of UK Canal networks. You can choose to take advantage of the lock free Ashby Canal and cruise past the Battlefield of Bosworth or navigate onto the Coventry Canal and enjoy a city break.
Book a seven night break for the family or for a group of friends save 40% off last minute holidays available until the 29th March. Alternatively you can book a short break away and save up to 30% off a mid week or weekend break, offering an ideal last minute getaway.
Click to search all our discounted boating holidays or all of central england canal boat holidays.
Our brand new base at Henley on Thames offers boaters a chance to cruise the famous Royal River and experience the heart of the Thames Valley.
The River Thames boasts a variety of attractions suitable for all the family. Visit the historic royal palaces, theme parks and Michelin starred riverside restaurants. The marina is within cruising distance of Oxford and Royal Windsor as well as well-known riverside towns such as Sonning, Wallingford, Bray and Marlow.
From Henley on Thames we can now offer a brand new Linssen 34.9 Grand Sturdy Class cruiser. This cruiser offers a luxury get away afloat for experienced boaters. Sleeping six in two spacious double cabins and one double sofa bed, this magnificent new boat 'Jacqueline' also includes features such as two bathrooms – each with toilet and shower – external steering position, bow thruster, swimming platform, central heating and wonderful views from the saloon.
The cost of a week's hire of Jacqueline starts from £1,500, rising to £2,500 in peak season inclusive of gas for cooking, bed linen, towels, car parking for two cars and instruction on arrival.
Click for more boating holidays on the River Thames, or on the Southern England Canals and Rivers.
We are now offering 15% off Norfolk Broads boating holidays from Wroxham on the River Bure. Book an Easter break for the family or for a group of friends, with discounted holidays available between the 29th March and the 13th April 2013. This offer expires on the 28th February 2013 – so not long left!
Click to search all our discounted boating holidays, or for more information on Norfolk Broads boat hire.
Since launching the new Waterways Holidays website in January, we've been busy upgrading our boating holiday search so that you can now check thousands of holidays using a brand new advanced search facility to find exactly the right holiday for you.
If you're looking for sailing yachts on the Norfolk Broads, you can search on our sailing holidays page to view traditional gaff rigs, bermudan rigs or yachts with showers onboard.
Top Tip – If you have performed a filtered search and would like to return to the original search, leave the boxes blank and press the 'apply selected filters' button to return to your original holiday search!
We hope you enjoy the new features and welcome any feedback. Once you have submitted an online boating holiday booking enquiry, we will endeavour to ring you back within 24 hours to go through the boating holiday details and offer friendly advice before you confirm your holiday.
Click to search all Canal Boat Holidays availability or to search for Norfolk Broads Boat Hire. To speak directly to one of our friendly team at Waterways Holidays Ltd, call us on 01252 796400, open 7 days a week.
NEW for 2013, Waterways Holidays features canal boating holidays near Devizes on the picturesque Kennet and Avon Canal.
Bradford-on-Avon – 5 hours by boat
A historic market town, there is a variety of interesting historic architecture dating from the Saxon period right through to the Industrial Revolution. Bradford on Avon is brimming with independant shops, including a selection of gift shops and tea rooms. You will find there are a couple of pubs on the water front, providing a convenient place to moor.
What to see: The 14th-century Tithe Barn and early 11th-century Saxon Church of St Lawrence.
Bath Valley – a picturesque section of the Kennet & Avon canal, situated between Bradford-on-Avon and Bath. Cruise through the hillside lined with forest, across the valley via the Aqueducts of Dundas and Avoncliff.
What to see: Dundas Aqueducts and Claverton pumping station.
Bath – 10 hours by boat
An attractive city with cobbled streets, stone buildings and a breath taking Abbey. The streets boast lots of shops, eateries and historic buildings. The city is overlooked by the steep hillsides lined with houses and dotted with fields. You can moor your hire boat either above the top lock and walk down into Bath, or navigate the six locks into Bath and moor below Pultney Bridge.
What to see: Roman Baths, the Abbey Church of Saint Peter & Saint Paul and an open bus tour of Bath
Bristol – 19 hours by boat
A major sea port associated with the exploration and trade with the new world. Walk along the floating harbour, which houses a selection of eateries, gallerys and bars. A great place to shop or explore the history of the port. Experience 'The Matthew', a replica of John Cabot's 1497 ship that discovered Newfoundland.
What to see: The SS Great Britain, moored in the docks and John Wesleys Chapel, the oldest Methodist building in the world.
Caen Hill Locks – if you are looking for an energetic start to your canal boat holiday, the Caen Hill locks will not dissappoint! 29 locks, bundled into three flights, raise your hire boat 237 ft in two miles. A marvel of canal engineering, created by John Rennie in the early 19th century. These locks can take between 5-6 hours to complete.
Devizes – 5-6 hours by boat
A medieval market town with a strong historic connection. There are several Norman Churches located in the town and a weekly market that can be dated back to 1609. The town is an easy walk down the towpath from the end of the Caen Hill locks.
What to see: the site of the 12th century castle and the surrounding medieval streets & buildings, Kennet & Avon Canal Trust Museum.
Newbury – 25 hours by boat
The main high street is easily accessible by boat and has plenty of thatched shops and market stalls, perfect for stocking up with boating holiday provisions. There is a pub situated next to bridge no. 60, or walk into town for a greater selection.
Reading – 33 hours by boat
The waterway runs right through the hub of Reading, with a selection of large eateries situated on the waterfront. You can moor away from the main town at the Abbey Ruins. Explore the Oracle shopping centre, spend the evening taking advantage of the nightlife, or take a walk down the winding streets off the main hub of Reading to find some independant shops and cafes.
What to see: Reading Abbey ruins
If you would like any further information regarding boating holidays in Southern England, boating holidays on the Thames or canal boat hire on the Kennet and Avon Canal, you can call one of our friendly boating team on 01252 796 400.
This year we're set to introduce even more boating holiday locations, including a brand new marina to Waterways Holidays located on the Leicester Section of the Grand Union Canal near Loughborough.
'Acumen II' is a cruiser stern narrowboat built in 2006. The boat has a fixed double cabin in the rear, with walk in wardrobe and a walk through bathroom with full length shower. The boat has central heating, a log burning fire, a LCD TV, DVD/CD/Video player, and a digital radio, combining the best of the modern and traditional facilities on board.
Starting from Loughborough you can cruise south in the direction of Foxton Locks via Leicester and onto the Market Harborough Arm of the Grand Union Canal. Market Harborough is a busy medieval market town surrounded by pleasant countryside where you'll find independent shops, bustling streets and plenty of places to eat.
Visit Leicester by boat and experience the National Space Centre located near Belgrave Lock 44, a perfect family day out with over 150 interactive exhibitions and challenges. Spend the evening in the De Montfort Hall, a popular venue for touring ballet and opera companies. Cruise south of Leicester and experience the bustling Foxton Locks, an excellent experience that will keep you and your crew very much occupied!
To celebrate the launch of specialist boating holiday agency, Waterways Holidays' new website, the company is highlighting 15% savings off all narrowboats hired from the Preston Brook base on the Bridgwater Canal in Cheshire.
www.waterwaysholidays.com features UK canal boat holidays and Norfolk Broads boat hire and offers live availability on a choice of more than 1500 narrowboats, cruisers, widebeam canal barges and Norfolk Broads sailing yachts operated by the UK's leading boat operators and with more than 60 different start locations. The website also offers lots of advice on boating holidays as well as featuring listings of the latest special offers.
The top features of the new website include:
The above offer is valid for bookings made by 31 January and means that a week's narrowboat hire from the Preston Brook base now costs from just £610 (saving £107) whilst a short break – three nights at a weekend or four nights' midweek – is reduced to £367 (saving £64).
These prices apply to Cheshire Cat and Quarry Bank Mill – both 45ft narrowboats sleeping four – and include all fuels (diesel and gas), damage waiver, bed linen, car parking, buoyancy aids, tuition on arrival and up to two well behaved pets.
To book a canal boat holiday or if you would like an boating advice, please dont hesitate to get in touch on 01252 796 400.
Dec 12
We are proud to announce the arrival of over 30 brand new boats to the UK Canals and Rivers.
'Wren 416′: a 47ft semi trad, is a perfect brand new canal boat for couples, with a fixed double cabin offering a wider double bed at the rear. Available from Hilperton on the Kennet & Avon Canal near Bath.
'Broad Oak': a brand new and unique boat built on the Lancaster Canal at Tewitfield. Broad Oak is a nine foot wide canal boat, offering the best of both worlds; the ease of handling of a narrowboat with the interior space of a wide beam. King size beds are available on board, with a spacious open-plan galley/lounge, and stylish modern high gloss units and solid oak surfaces.
'Sovereign Light': a brand new dual steer cruiser offering unrivalled luxury, space, décor and amenities. Featuring an external upper sundeck with integral sunbathing platforms and alfresco dining area perfect for entertaining. Stylishly appointed saloon with raised steering position and additional forward facing seating so that all crew can enjoy the visibility of the helmsman.
'Amber Emblem': a stylish boat new in 2012, with a sliding back canopy and raised centre cockpit. The stern deck has a low boarding platform to provide easy access and the boat is equipped with bowthrusters, modern eco-hull design and flat screen tv with Freesat.
The motor cruiser fleets at Thorpe St Andrew, near Norwich and Chedgrave on the Norfolk Broads have both been expanded, offering more boat choices for customers looking to cruise the tranquil Southern Broads.


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A crop of American cockroaches brings in serious cash.
Charlotte - Mecklenburg School (CMS) district and Central Piedmont Community College (CPCC) will make individual presentations on Monday to Mecklenburg County Commissioners.
This is budget season and both organizations depend on county government to help pay their bills.
CMS wants more than $400 million from the county, that's $46.2 million more than it received last year. $27 million would go to pay for a 3% raise for all CMS workers. At the meeting commissioners asked CMS superintendent Dr. Heath Morrison is a raise the state's responsibility? This is how Morrison responded.
"For this to change it's going to require different parties to come together," Morrison said. "Local officials coming together, everybody coming together instead of causing blame."
CMS also wants more money to pay for special programs and take care of growth. County Commissioners have told WBTV CMS' request is just too much and the county cannot afford to grant that request. Commission Chair Trevor Fuller hinted
"We have put our money where our mouths are," Fuller said. "We simply cannot bear the burden alone, we simply can't."
Morrison laid out the reasons why the county should give the money and try to convince county leaders to approve their request. CMS used a teacher, bus driver, and three students to tell commissioners the district needs more money.
During the meeting, Fuller told the crowd despite what people may think the county does support education.
"Right now the county is funding education," Fuller said. " When you look at operation and capital debt service to the tune of a half billion dollars."
Commissioners also requested the conversation about the budget talk be toned down. Commissioners expressed their concern about people attacking them over the budget. They hope this conversation will be a friendly one.
CPCC leaders are requesting $34.1 million from the county, that's nearly $3 million more than CPCC received last year from the county.
They also presented Monday. The money would go to help maintain parking decks, roof replacements, security upgrades and other capital projects.
CPCC officials laid out reasons why the county should grant their request.
After the meeting County Manager Dena Diorio says she was moved but will it be enough to grant CMS and CPCC their requests. She will unveil her budget on May 29.
To see CPCC's budget request, click here.
Copyright 2014 WBTV. All rights reserved.
1 Julian Price Place
Charlotte, NC 28208
FCC Public File
EEO Report
Closed Captioning


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Select () or exclude () categories to narrow your recipe search.
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Kraft roasted red pepper italian parmesan dressing
Getting dinner on the table just got a whole lot easier.


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Discount Ski Packages - Skis With Bindings - Women'sBe smart and get Discount Ski Packages today! Offering you Ski and Binding packages for Women, Proboardshop.com is the perfect place to get your significant other the skis and bindings she wants for one eye opening price. Make the next trip the one of a lifetime and purchase Ski and Binding packages for both men and women from Proboardshop.com.
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Thermostats Control your Comfort System
Thermostats are the interface to the heating and air conditioning system. Thermostats exist in a variety of technologies, from a simple temperature on-off control to a sophisticated computerized … [Continue Reading]
HVAC Financing
Carolina Heating Service Inc. has teamed up with Wells Fargo Financial National Bank to provide our customers the financing support you deserve for your heating and air conditioning project: HOME … [Continue Reading]
Comfort Matters
Our people know equipment and as authorized dealer for Carrier, Mitsubishi, Trane, WaterFurnace, Generac and more, our customers have a full line of Comfort Equipment at their fingertip. What are … [Continue Reading]
Heating & Air Services
- Residential, Commercial
HVAC Repair All brands and models, residential or commercial with 24hour service! Call us at 864-232-5684 or toll free 800-261-0359 Troubled about too many expensive repairs? Read here about … [Continue Reading]
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Geothermal Map
Carolina Geo Heating, the geothermal division of Carolina Heating Service Inc., provides expert services in the field of geothermal or ground source … [Read More...]
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Careers – Job Openings
Carolina Heating Service is always looking for good people who want to work in the field of HVAC (heating and air conditioning). As a dynamic contractor in the Greenville SC area we are especially … See all current jobs ...
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Indoor Air Quality is actually paraphrasing the real issue: Indoor Air Pollution. And Humidity is the other contributor to indoor air quality. Watch the interview with a local TV … Read more ...
Carolina Heating serves customers in the Upstate of SC including Greenville, Easley, Anderson, Spartanburg SC
Nothing works like a Trane....... except a Carolina Heating Service engineer! Aaron Courier worked his magic in SC, in August, during the hours most people treasure as lunch time (beyond hot). Thank you for exceptional service. ...View on Facebook
Aaron Courier, Senior Technician, with Carolina Heating, is the Tech I request each time for the semi-annual inspection of my Generac Generator and HVAC. He is a true professional, friendly, respectful, knowledgeable, and I trust him working on my systems. Thanks Carolina Heating for your annual service contracts, and my favorite technician, Aaron. What great peace of mind, especially during the winter months! Be sure to look at the picture of him working on my HVAC >>>>> ...View on Facebook
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HVAC Replacement – Thank-you Note from Mary
August 8, 2014 By Alexander
Feedback from Mary with Integrations received by Mark Dyer (HVAC Sales at CHS): I recently had to replace my HVAC—never a happy thing! I live in an historic home, built in 1864, so the work required special consideration and attention. In addition to removing 3 systems and old duct to boot, the crew had to […]
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Mark Dyer (HVAC Sales) received the following thank-you note from Kay and Rich C in Greer SC: I would like to thank you for the great service and professional help you gave us. Rich and I are very pleased with our Mitsubishi split unit. The fellows that installed it were very courteous and did a great job. Sure […]
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WaterFurnace has released a new tool that we have been looking at for a long time, The Savings Calculator for Geothermal Heating and Air Conditioning. We have reviewed and compared this calculator to real live results of our customers and found that it provides an astonishingly good estimate of savings considering the many parameters influencing […]


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SALEM, N.H. — Crazy hats, worn T-shirts, a passion for adventure and a loud, hearty laugh — that was Shawn Hogan.
Approximately 200 people paid their last respects to the 28-year-old Army captain and Green Beret during a funeral service yesterday at Mary Queen of Peace Church.
There were probably more laughs and fond remembrances at the hourlong service than tears and mourning. After all, Hogan would have wanted it that way.
"Shawn never stopped — he always kept going, living life with no regrets," college friend Nick Mazzenga said.
Hogan, stationed at Fort Campbell in Kentucky, was killed Oct. 17 when the all-terrain vehicle he was riding overturned during a training exercise. He was a 2002 graduate of Salem High School and valedictorian of his graduating class at Virginia Military Institute.
Hogan received military honors and about 50 of his comrades were in the audience, as was Gov. John Lynch.
Sixteen members of the Patriot Guard Riders stood outside the church, holding flags. Green Berets stood at the door as the crowd filed into the church, where Hogan's flag-draped coffin sat up front.
The Rev. Thomas Frink opened the service. Hogan's accomplishments and love for life were described by Master Sgt. Jonathan Ramer.
"Shawn was known for his passion for adventure, his humility and for spending his time laughing with friends," Ramer said. "Through his contagious personality, never-ending smile and youthful joy for life, he could make anyone feel as though they were his best friend in only a matter of minutes."
Mazzenga was one of four friends who paid tribute to Hogan, recalling his energy, intelligence and independent spirit. But they especially remembered his love for adventure, describing boyhood stunts and daring deeds as an adult.
He definitely made his presence known, whether it was his taste for wearing unusual hats and oversized sunglasses, or what his friends called his loud, goofy laugh and wacky sense of humor.


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Movie play
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This conversation is closed.
If communism was working the way its progenitors wanted it to, would it be better than capitalism?
The main reason why communism was made was people wanted to be equal without getting restricted by their environment, but nowadays communism is abused by some dictators such as North Korean leaders. Besides, capitalism also has its own problem. There are so many people who didn't have opportunities to try what they really wanted to do due to their poverty or else.
If communism was working as it should be, would it be better than capitalism?
(When there are no dictators)
Showing single comment thread. View the full conversation.
May 3 2013: ...life is always in balance...as Buddha quotes The Middle Path...Extreme of everything is always poisonous...the equality under communism is always a matter of debate...equality in opportunities, behaviour, efforts or in results...I believe first three must not be challenge-able, the challenge is hidden in fourth...and this is to be understood...
...as it is for fruits so as for ownership...ownership is energy...energy converts to power and greed... and communism looses it's practicability...
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The Tenth Circuit Court of Appeals published its opinion in United States v. Porter on Thursday, March 6, 2014.
Following a jury trial, Defendant-Appellant Gloria Porter was convicted of 105 counts of wire fraud, one count of mail fraud, and one count of identity theft. The National Federation of Federal Employees ("NFFE") is an independent federal union that represents federal workers. The NFFE is comprised of five councils, which in turn are made up of approximately two hundred "locals." Porter joined the NFFE in 1992. She was a member of Local 2049 at White Sands and served as its president. She also served as secretary/treasurer of the Armed Material Command ("AMC") Council (one of the NFFE's five councils) and as national vice president of the NFFE. She was secretary/treasurer of the AMC Council from 2002 to 2008, and was the only active signatory on the AMC Council's bank account.
Starting in August 2004 and throughout her time as an NFFE officer, Porter created fraudulent bank statements on her computer and sent them to NFFE officers, while having the authentic bank statements sent to her home address. The NFFE took away Porter's authority over the union's bank account, and, after both the NFFE and IAM conducted their own audits of their accounts, the matter was turned over to the United States Department of Labor ("DOL") for further investigation.
Porter appealed her convictions, claiming that the district court erred by instructing the jury that a signature is a "means of identification" for purposes of the aggravated identity theft offense. Porter argued that the word "signature" is not expressly mentioned in the statutory definition of "means of identification" found in § 1028(d)(7) and a signature should not be viewed as a form of a "name"—a term that does appear in that definition. The Tenth Circuit found the reasoning of a Ninth Circuit case, Blixt, persuasive in holding that a signature is a form of "name" for purposes of § 1028(d)(7)'s definition of "means of identification."
Porter also argued that the evidence was insufficient to support her convictions for wire fraud and mail fraud. The court found her arguments to be without merit and affirmed her convictions.


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For most people, accepting Facebook friend requests is not much of a burden. Requests trickle into your inbox from time to time, you open the Facebook notifications page, press accept, and move on. Some people, however, may get many requests each day, so many that it becomes a real problem to deal with all of them in a timely manner.
For example, let's say you're doing an internet promotion, and it really starts to take off. Accepting hundreds of requests per day could take up a lot of time. Another example would be someone coordinating a large event. If there was a way of quickly accepting all these requests, it could save you a considerable amount of time.
Unfortunately, Facebook does not provide any tools or setting to automatically accept friend requests, however with a little work, it is possible to build your own solution. Let's see how.
The Javascript way
The most common way to accept multiple requests is by using Javascript; here's an example.
Go to http://www.facebook.com/friends/edit/?sk=requests. This will bring up all of your outstanding friend requests.
javascript:for( i = 1;i<document.getElementsByName("actions[accept]").length;i++){document.getElementsByName("actions[accept]")[i].click();}void(0);
- Press enter, and all of your outstanding friend requests will be accepted.
Rejecting Requests
Some people have the opposite problem: unwanted friend requests that must be rejected en masse. An example may be someone who suddenly becomes well-known, and has hundreds or thousands of strangers trying to friend them. Fortunately, the same technique, with slightly different code, can be used to reject all incoming friend requests:
- Once again, go to http://www.facebook.com/friends/edit/?sk=requests to bring up all of your outstanding friend requests.
- Enter this code in the address bar:
javascript:for( i = 1;i<document.getElementsByName("actions[hide]").length;i++){document.getElementsByName("actions[hide]")[i].click();}void(0);
- All of your outstanding friend requests will be rejected.
Going Further
While this technique is fairly easy to use, it could get painful if you had to do it manually multiple times per day. For users that need to use these scripts frequently, there are several ways to automate the process.
Browser Extensions
For FireFox, the Facetweak extension provides a one-click implementation of the above process, plus other handy Facebook-specific tools. No extensions to automatically accept or reject friend requests currently exist for other browsers, but keep looking, since new extensions are added all the time.
Text expansion
On the mac, TextExpander is a popular text expansion utility, while Keyboard Maestro is one example of a macro utility. On Windows, try PhraseExpress for text expansion and AutoHotkey for macros.
After recording the text, just press the hotkey you assigned to it to go to the correct web page, then press another hotkey to enter the JavaScript to accept the requests.
For the more advanced users, small programs written in PHP, JavaScript, or other scripting languages can be used to automate this process. Using this approach would not only allow for automation of friend request acceptance, but also allow you to set up scripts that run automatically at a preset interval, or perform more complex processing, such as setting aside some requests for your personal review. For ideas on how you could construct your own scripts, see sites such as thisuserscripts.org example or another userscript.org example for sample scripts to get you started.
If you would like a more powerful way to control Facebook, you can also develop code that connects directly to the service's Application Program Interface (API). This method will allow you the maximum amount of control, not only for accepting friend requests, but for other tasks.
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