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tag:blogger.com,1999:blog-1136153439451224584.comments2014-09-01T21:11:28.198-07:00Practical FragmentsDr. Teddy Zhttp://email@example.com:blogger.com,1999:blog-1136153439451224584.post-35842228658151284052014-09-01T21:11:28.198-07:002014-09-01T21:11:28.198-07:00While not wanting to self-cite, see this url and t...While not wanting to self-cite, see this url and these refs to get a good idea of recognizing likely PAINS:

https://www.collaborativedrug.com/buzz/2010/03/08/guest-blog-dr-jonathan-baell/

Baell JB. Observations on Screening-Based Research and Some Concerning Trends in the Literature. Future Med. Chem. 2 (2010) 1529–1546

Baell JB & Holloway GA. New substructure filters for removal of pan assay interference compounds [PAINS] from screening libraries and for their exclusion in bioassays. J. Med. Chem. 53 (2010) 2719-2740

Baell JB. Redox active nuisance screening compounds and their classification. Drug Discov. Today 16, 840-841 (2011)

Commercial libraries tend to have 5-12% PAINS. Usually not removed. But not a big deal if you are aware....always be wary of any hit...it has to prove itself right and not the other way around.
firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-83435342352641660872014-09-01T12:59:20.168-07:002014-09-01T12:59:20.168-07:00Hi. 2 Qs for the PAIN experts: 1. Is there a "...Hi. 2 Qs for the PAIN experts:
1. Is there a "complete/near-complete" list of pains found in literature somewhere (blogs/papers). Or maybe you can point to a comprehensive one. It would be a useful tool to hold future hits and libraries up against.

2. Should one expect/fear pains in commercial libraries (eg Maybridge). I know aggregators are hard to predict, but can i count on that they have removed H2O2 generators, Michael acceptors, S-S creating compounds?

Great blog email@example.com:blogger.com,1999:blog-1136153439451224584.post-3068321884352491832014-08-29T11:55:41.934-07:002014-08-29T11:55:41.934-07:00I stand corrected...kinda. I should have written ...I stand corrected...kinda. I should have written first de novo fragment hit for a PCI.Dr. Teddy Zhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-71013175659943891442014-08-29T06:19:44.693-07:002014-08-29T06:19:44.693-07:00This is a nice paper, though there have been other...This is a nice paper, though there have been other fragment papers targeting carbohydrate binding proteins, two of which we've covered here and here. The real challenge, of course, will be getting something with high affinity.Dan Erlansonhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-79283429416796069972014-08-28T20:57:40.462-07:002014-08-28T20:57:40.462-07:00Excellent example to screen the Synpha Library Ro3...Excellent example to screen the Synpha Library Ro3STJhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-89570416243679243602014-08-28T16:59:59.253-07:002014-08-28T16:59:59.253-07:00Teddy -- I said "avidly". I have seen t...Teddy -- I said "avidly". I have seen teams (internal and at potential "partners") optimize "potency" without regard to functional effects.

Delivering a potent ligand of absolutely no use to me.

I really don't care who makes the molecules, or who drives the project. Someone needs to keep their eye on the ball.

(I vehemently disagree with the comment above that "no single person has the expertise . . . to unilaterally make decisions on the direction the project takes" BTW. I know several such people. Rare, true, but not unknown.)

email@example.com:blogger.com,1999:blog-1136153439451224584.post-8350452314713865372014-08-28T13:34:55.101-07:002014-08-28T13:34:55.101-07:00@Anonymous, why would you expect a weakly binding ...@Anonymous, why would you expect a weakly binding compound to necessarily have a functional effect? Dr. Teddy Zhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-78444645996622213482014-08-28T13:28:21.352-07:002014-08-28T13:28:21.352-07:00More and more, particularly in PPI targets, I am s...More and more, particularly in PPI targets, I am seeing project teams come forward with molecules that bind avidly to the target protein. The biophysicists and CADD guys (and gals) are justifiably proud of their contributions,

Unfortunately, too often, these molecules do nothing functionally, and thus are essentially useless as starting points for a drug discovery project. A (decent, or at least trained by me) medicinal chemist would have asked that question up front.

So, there is still education to be imparted, on both ends. As noted above, "most important" misses the point. firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-9542854662087718062014-08-25T09:10:04.388-07:002014-08-25T09:10:04.388-07:00Edited for correctness: I agree with Dr. Guy, publ...Edited for correctness:
I agree with Dr. Guy, publish NEW molecules that end up being PAINS. Something like this, which as Dan points out, has been known for 5 years, needs not be published in a journal like this..Dr. Teddy Zhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-35400981029194635122014-08-24T05:28:43.873-07:002014-08-24T05:28:43.873-07:00Forgot to include link for 'Data-analytic sins...Forgot to include link for 'Data-analytic sins in property-based molecular design' in previous comment. Apologies for omission and here's the missing link: http://www.slideshare.net/pwkenny/data-analyticPetehttp://email@example.com:blogger.com,1999:blog-1136153439451224584.post-53811463143468434352014-08-23T14:06:56.146-07:002014-08-23T14:06:56.146-07:00Hi Dan, If we're going to invoke usefulness in de...Hi Dan, If we're going to invoke usefulness in defense of LEMs, we do need to articulate clearly exactly how they are being used. If is often stated that the function of LEMs is to normalize activity with respect to risk factors such as molecular size and lipophilicity. Unfortunately, the people making these statements rarely (if ever) state exactly what they mean by 'normalize' which makes it difficult for the users to know whether or not the proposed LEMs are fit for purpose. In our Perspective, we argued that arbitrary assumptions (e.g. standard/reference concentration for LE; coefficient of lipophilicity in LipE) are made when defining LEMs. We also showed that making equally plausible assumptions (e.g. changing standard/reference concentration) can change the ranking of compounds. When we assert that LEMs are useful because people are using them, we are actually making a statement about the users rather than the science. Personally, I would regard a view of a system as invalid if the view changed when we changed the units of the quantities that define the system. Pauli might have noted that such a view was, "not even wrong".

In the Perspective we also argued a case for modelling the response of activity to risk factor as an alternative to using LEMs. We also made the point that using LEMs distorts analysis. Although we suggest using residuals to quantify 'bang for buck' of compounds in drug discovery projects, you could easily use the intercept (pIC50@0) from the linear fit of pIC50 to HA to redefine LE as (pIC50-pIC50@0)/HA. It would also be feasible to do something similar for LipE (e.g. we defined a generalized lipophilic efficiency in the Perspective). One advantage of modelling the activity data and using residuals is that you're not restricted to linear responses of activity to risk factor. I see efficiency as defined by the response of activity to risk factor(s) and my main criticism of LEMs is that they distort our perception of that response. The key question (which we posed in the Perspective) is whether or not you would regard pIC50 values lying on a straight line when plotted against risk factor as representing equal efficiency with respect to that risk factor.

The Perspective will have hopefully at least got some members of the FBDD community asking themselves why they use LEMs and whether they consider it valid to mix results from different assays in LEM-based analyses (e.g. mapping chemico-biological space; size-dependency of LE). One point that I make when presenting 'Data-analytic sins in property-based molecular design' ( ) is that if we do bad data analysis (or bad science) then we open ourselves to suggestions that some of the difficulties in drug discovery may be of our own making. The anti-fat/anti-flat brigade and self-appointed arbiters of compound quality may also find it prudent to consider this point carefully.Petehttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-4095294882015508992014-08-21T06:47:49.012-07:002014-08-21T06:47:49.012-07:00I always think discussion about who is the most im...I always think discussion about who is the most important is missing the point. You can be as great a Med Chemist or Biophysicist as you like, but no one single person has the expertise in biology, chemisty, biophysics, assay dev, DMPK, safety etc to be able to unilaterally make decisions on the direction the project takes. I really think our industry has struggled over the past two decades because Medicinal Chemists ruled the roost to the detriment of other equally skilled scientists in other fields. I think it would be equally foolish for biophysicists to assume they can replace medicinal chemists in this role.

For me the key to successful drug discovery is team work, humility and knowing where the limits of your knowledge firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-66266674813794698452014-08-21T05:14:28.719-07:002014-08-21T05:14:28.719-07:00Derek comments on it: http://pipeline.corante.com/...Derek comments on it: http://pipeline.corante.com/archives/2014/08/21/fragonomics_eh.phpDr. Teddy Zhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-61194347047450235322014-08-21T03:56:04.363-07:002014-08-21T03:56:04.363-07:00Not saying they aren't essential. I am saying...Not saying they aren't essential. I am saying the need for their engagement has been pushed back in the whole process, thereby easing a resource crunch early in the process and putting them later where they have more impact.Dr. Teddy Zhttp://email@example.com:blogger.com,1999:blog-1136153439451224584.post-46034905969910326662014-08-20T20:31:28.852-07:002014-08-20T20:31:28.852-07:00A key statement Pete makes is: "I certainly ...A key statement Pete makes is:

"I certainly agree that lipophilicity is a physicochemical property that has to be managed and my challenge to wannabe key opinion leaders is all about how it should be managed and not at all about whether or not it needs to be managed."

Given that we all agree that lipophilicity needs to be managed, does it really matter all that much which metrics we use? Sure, LLE, LLEAT, LELP, etc. are all somewhat arbitrary, but that doesn't mean they can't be useful for managing lipophilicity and molecular weight.Dan Erlansonhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-42126254651476182992014-08-20T20:26:48.600-07:002014-08-20T20:26:48.600-07:00Much as I'd like to visit Valinor, I'd say...Much as I'd like to visit Valinor, I'd say that medicinal chemists are still just as essential today as they ever have been. Not only are we needed to design libraries and avoid PAINS, it's pretty difficult to transform a millimolar fragment to a lead - let alone a drug - without medicinal chemistry!Dan Erlansonhttp://email@example.com:blogger.com,1999:blog-1136153439451224584.post-15200376203488472032014-08-20T01:48:45.669-07:002014-08-20T01:48:45.669-07:00Part 2/2 The assertion, "Without convincing evide...Part 2/2

The assertion, "Without convincing evidence to the contrary, drugs should be made as hydrophilic as possible without loss of efficacy" has some value as an aspirational goal but does not provide much guidance as to how lipophilicity should be managed in a non-ideal world where hydrophobic interactions need to be exploited to achieve the affinity required for activity. Probably a good idea in a discussion like this to skip the hagiography and take a close look instead at how we ended up with octanol/water as the preferred partitioning system.

I should respond to, "Mike Schultz's bottom line that LipE, LLE…(i.e. potency minus lipophilicity in some form) is what really counts - is exactly in line with the anti-fat movement! (Of course we should add flat to that statement too)". As mentioned earlier, you need to say why we should use potency minus lipophilicity (as opposed to potency minus 0.5 x lipophilicity). I do have an issue with saying that "we should add flat to that statement" and the "of course" cannot, of course, hide the weakness of the some of the data analysis in that area. For example, the analysis of the relationship between solubility and Fsp3 greatly exaggerates the trend in the data and represents a particularly tortured way to explore the relationship between two continuous quantities. As an aside, you may find it instructive to take a look at the structures of the compounds in that data set (which is publically available). Some of the other work in this area fails to acknowledge that number of aromatic rings may simply be a surrogate for molecular size (which is widely assumed to be a risk factor in drug discovery. I was puzzled one study in which continuous variables were binned to generate graphical data representations which were then used to assert that one trend was stronger than another. The following quotes should give you an idea of what I'm referring to:

"The clearer stepped differentiation within the bands is apparent when log DpH7.4 rather than log P is used, which reflects the considerable contribution of ionization to solubility".

"This graded bar graph (Figure 9) can be compared with that shown in Figure 6b to show an increase in resolution when considering binned SFI versus binned c log DpH7.4 alone."Petehttp://email@example.com:blogger.com,1999:blog-1136153439451224584.post-88127778793280031862014-08-20T01:48:13.542-07:002014-08-20T01:48:13.542-07:00Part 1/2 Hello Anonymous, I disagree with your re...Part 1/2

Hello Anonymous,
I disagree with your recommendation, "Ignore correlations - look at the emerging patterns and probablistic implications of the data (especially PFI!)" and I remain unfamiliar, even after googling, with the term PFI. If you want people to use patterns, emerging, emerged or otherwise, to make decisions then you need stop waving your arms and be honest with those people about how strong the associated trends are. The large data sets available to Big Pharma researchers often lead to eye-wateringly good P-values for trends that have no real predictive value. In the prediction business, effect size trumps significance. Knowing with confidence that a coin comes up heads 51% of the time is of no real value to the person charged with calling the result of the next throw.

Some (most?) of the drug-likeness data analysis in the literature appears to be more about giving weight to pre-existing opinions than answering questions objectively. While making trends appear stronger than they are does add weight to one's opinions, there is a credibility risk should one get caught. In this regard, it may be instructive to remember the fable about the boy who cried wolf and the saying about what opinions have in common with hemorrhoids. It's also worth thinking what would happen to a professional sportsman if he were caught doing the equivalent of inflating a correlation.

Since you've highlighted the importance of "MEASURED hydrophobicity" values, you'll know that it is logD that is measured and not logP (although the two quantities are the same when the compound is ionized to a negligible extent at the pH of the measurement). It can be argued that logP is the more appropriate measure of lipophilicity for modelling some phenomena while logD may be more appropriate in other situations. However, I would usually try separate the ionization and logP components of logD prior to any modelling. I certainly agree that lipophilicity is a physicochemical property that has to be managed and my challenge to wannabe key opinion leaders is all about how it should be managed and not at all about whether or not it needs to be managed. For example, why is pIC50 – ClogP a better metric than pIC50 – 0.5 x ClogP? An analogous challenge was presented to the solubility forecast index. Put another way, if you want people to use your metrics, indices and rules of thumb in decision making then these metrics, indices and rules of thumb need to be based on relevant, relevant and honest analysis of the available data.Petehttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-60216263798555962122014-08-19T06:13:55.168-07:002014-08-19T06:13:55.168-07:00I'm not all that amazed with this outcome. Tho...I'm not all that amazed with this outcome. Though linking two fragments binding to different hot spots within a given binding site may appear conceptually beguiling, it is more likely to fail. First, the optimal orientation of the two independent fragments may be perturbed upon linking. Second, induced fit of a fragment binding with high efficiency to a specific hotspot may be disrupted when another fragment binds to an adjacent hotspot. So I would predict quite a bit of negative cooperation .Luc Van email@example.com:blogger.com,1999:blog-1136153439451224584.post-7700373656976499782014-08-19T03:46:17.873-07:002014-08-19T03:46:17.873-07:00When people start to take note of data based on ME...When people start to take note of data based on MEASURED hydrophobicity values - realsing that for insoluble compounds the octanol water system is a random number generator - then people will understand the patterns emerging. Mike Schultz's bottom line that LipE, LLE... (i.e. potency minus lipophilicity in some form) is what really counts - is exactly in line with the anti-fat movement! (Of course we should add flat to that statement too). What does stand the test of time is the quality of Hansch's work and how well ClogP performs (but is ignored - or not corroborated by flawed OW measurements). Note too, a forgotten statement of the great man "Without convincing evidence to the contrary, drugs should be made as hydrophilic as possible without loss of efficacy"
Hansch C., Bjorkroth J., Leo A., J. Pharm. Sci., 76, 663 (1987). Ignore correlations - look at the emerging patterns and probablistic implications of the data (especially PFI!). And LE DOES have value - when used with due email@example.com:blogger.com,1999:blog-1136153439451224584.post-39763906883015474032014-08-18T15:29:06.133-07:002014-08-18T15:29:06.133-07:00Of course Mike Schultz could have pointed out the ...Of course Mike Schultz could have pointed out the formula for LE in the Murray et al critique of his study was itself mathematically invalid. Correct me if I'm wrong, but didn't Molecular Obesity reproduce the plot of promiscuity against median(ClogP) that had a starring role in Correlation Inflation ( see http://dx.doi.org/10.1007/s10822-012-9631-5 ) ?Petehttp://email@example.com:blogger.com,1999:blog-1136153439451224584.post-58455579401219324252014-08-17T10:22:07.969-07:002014-08-17T10:22:07.969-07:00Vernalis and Servier recently announced that their...Vernalis and Servier recently announced that their BCL-2 inhibitor has entered Phase I:

http://www.vernalis.com/media-centre/latest-releases/684-vernalis-and-servier-achieve-research-milestone-as-bcl-2-inhibitor-drug-candidate-enters-phase-iDan Erlansonhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-61202392447157650082014-08-14T07:52:03.455-07:002014-08-14T07:52:03.455-07:00I read with interest this article guys and I agree...I read with interest this article guys and I agree with you that we should be cautious using this approach. But I'm happy to see this could be applied to fragments too. I worked on the so called TCIs (targeted covalent inhibitors)in a project on a kinase target at Cellzome (now GSK) looking for reactivity vs glutatione and it worked beautifully, obtaining potent and selective compounds. For people interested I suggest to read this article: NATURE REVIEWS DRUG DISCOVERY, 2011, 10, email@example.com:blogger.com,1999:blog-1136153439451224584.post-92171752146590436552014-08-14T05:23:27.984-07:002014-08-14T05:23:27.984-07:00I also think the past is not prologue. Just becau...I also think the past is not prologue. Just because there are drugs on the market that were approved 50,60 years ago does not mean they would be approved today. Here is an interesting take on whether isoniazid would be approved or not: http://www.fda.gov/downloads/Drugs/ScienceResearch/.../ucm076755.pdf Dr. Teddy Zhttp://firstname.lastname@example.com:blogger.com,1999:blog-1136153439451224584.post-12267384274051857972014-08-06T10:41:32.722-07:002014-08-06T10:41:32.722-07:00In the "small wield" category, Matt and...In the "small wield" category, Matt and I were on a bowling ( read: drink beer) team at Lilly. Before you ask, my handicap is 80 or so. Dr. Teddy Zhttp://firstname.lastname@example.com


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Hi friends,
I'm building an application in which i've used the com.nokia.mid.ui.FullCanvas class for FullScreen in MIDP1.0 as it doesn't support setFullScreenMode(boolean) method.Where i've consider its width and height of Canvas to aligned the text.
When i'm using this application for MIDP 2.0 supported device so i used normal method of Canvas setFullScreenMode(boolean) instead of com.nokia.mid.ui.FullCanvas .But the text on the screen is not aligned well.
Whatever calculation i've done using the Canvas's Width and Height are diffrent for both of them ( com.nokia.mid.ui.FullCanvas and Canvas class)?if so why is it so?
Are there in any Known Issues of com.nokia.mid.ui.FullCanvas ?
Does there is any diffrence between com.nokia.mid.ui.FullCanvas and Canvas class?
Sachin Warang.

subset: commoncrawl


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"Since I participate in Colombianitos I have learned a lot of important things as to be on time, responsible, respectful. I also thank for the workshops that I didn't have access to before being part of the organization. I am more dedicated to my studies and my family now. I have learned a lot thanks to Sergio and Sebastian (Soccer Coaches), to respect and take care of all what can help us be better human beings in the future. The most important thing is that I have learned is to be clean with myself and with my things" Male – 17 years old
Colombianitos News
Ministry of Interior Launches Ten-Year Football´s Plan together with "Colombianitos"
"Tiempo de Juego" & "Contexto Urbano"
The strategic goal is eradicate the violence inside and outside the stadiums, and become this sport in a tool to built pace and democracy.
The construction of this policy was a commitment of President Juan Manuel Santos with enthusiast and leaders of this sport, that was leaded by the Minister Iragorri Valencia together with Tiempo de Juego, Colombianitos and Contexto Urbano.


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Duke gets sneak peak at top-secret new game during Neon Play visit (From Wilts and Gloucestershire Standard)
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The Duke of Kent got a sneak peak at top-secret new game during Neon Play visit
6:30am Thursday 13th March 2014 in News By Megan Archer, Reporter
A MOBILE games company gave a royal visitor a sneak preview of a brand new and top secret app when he came to visit Cirencester last week.
HRH The Duke of Kent visited Neon Play last Thursday to meet the team and to get a glimpse of Neon Play's latest project.
After arriving by helicopter in Cirencester Park, The Duke was greeted by Lord Lieutenant for Gloucestershire Dame Janet Trotter and Lady Bathurst before being taken to the Neon Play office at the Old Museum.
Dame Janet said it was wonderful to see the Duke of Kent land in the historic Cirencester Park before being taken straight into the 21st century with a tour of Neon Play's ultramodern offices.
He was welcomed at the door by Neon Play founders Mark Allen and Oli Christie, the chief executive.
Also present were High Sheriff of Gloucestershire Hugh Tollemache, chairman of Gloucestershire County Council Cllr Tony Hicks, chairman of Cotswold District Council Sir Edward Horsfall, and Cirencester Mayor Cllr Joe Harris.
Oli gave the Duke a tour of the modern and colourful office and explained in detail what each employee was working on. He also gave the royal visitor a sneak peak at a new game in development, which is closely-guarded secret.
The Duke is said to be keen on technology and divulged during the tour that he uses an iPad.
"This has so far been a largely closed world for me and it's been a very interesting day," he said. "Especially seeing how Neon Play has achieved so much in such a short amount of time."
Oli said the whole team was "very honoured" at the visit and he paid tribute to his staff.
"Without them, nothing is possible," he added. "We are very fortunate to have such a talented and fun bunch working here."
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Leading by four, CATS GIVe up next 13 runs
• Highlights: Kent Matthes' bases-loaded double gave the River Cats a 3-0 lead in the top of the first inning, but they allowed host Salt Lake to score the last 13 runs in a 13-4 loss Friday night at Smith's Ballpark. Jose Martinez, Nate Freiman and Michael Taylor drew walks in the first to set up Matthes' double to right field. Shane Peterson's solo home run gave Sacramento a 4-0 lead in the second.
• Pitching report: River Cats pitching was pounded by the Bees, who had 13 hits, and Sacramento was generous, too, issuing nine walks. Starter Sean Murphy was charged with five runs and six hits in 41/3 innings, and Jeremy McBryde allowed five runs and four hits in 11/3 innings. Philip Humber entered the game with the bases loaded and two outs in the sixth and allowed a three-run double before getting out of the inning.
• Today: River Cats RHP Joe Blanton (0-0) vs. Salt Lake RHP Joe Martinez (0-0), 5:35 p.m., Smith's Ballpark.
– rivercats.com


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Flint Police are continuing to investigate a shooting at a house party that left three people injured.
The Flint Journal reports the incident happened early Sunday morning at a party on Sterling Street.
All three people shot are expected to be fine. Police have no suspects.
Police are also investigating another shooting that happened Friday on West Pierson Road.
Police say one person was killed and they're looking for two men who they say are persons of interest.
If you have any information on either of these shootings, you're asked to call Crimestoppers at 1-800-SPEAK-UP.
Callers will remain anonymous.
Copyright 2014 WNEM (Meredith Corporation). All rights reserved.


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"With high base salaries, opportunities to work lucrative construction details, and one of the nation's most generous overtime programs, Boston's rank-and-file police officers brought home $78,906 on average in 2002, and those who earned higher-education degrees made considerably more....Many detectives now receive salaries in excess of $90,000 a year.""Average pay for Boston police patrolman, including overtime and other benefits...: $81,725 [in October 2004]"
"I got the impression from Darrow's "they upload to secure sources" comment that he might have more than just a recorder back there. I've thought about doing something like this for a long time, and with EVDO rev A and HSUPA it's finally getting practical. I'd want a laptop recording to local storage constantly, and when I flip a switch or press a button, it starts sending the last few minutes of video plus a constant realtime stream to some off-site host, so if the car is impounded or tampered with, the video survives.posted by ericb at 3:26 PM on September 27, 2007 [1 favorite]
Looks like the software side is gonna be strictly homebrew.
Little NTSC cameras are all over the place, and they're cheap. I'd want one facing forward from the rear, perhaps mounted in the third taillight, to capture actions in the pasenger compartment and out the front of the vehicle. I'd also want one facing back and left, perhaps mounted in the dash, to show the driver's and officer's actions more clearly."
When he sees the camera he said he would tear all of them apart. Only after I lie and tell him they are being uploaded to a secure source does he start sucking up to me. He even asked me one more time before I got in the car if the tape was in my trunk.posted by rtha at 5:45 AM on September 28, 2007
"But 'Little Brother' checking up on 'Big Brother' is just what democracy needs....The case of 20-year-old Brett Darrow from St. Louis represents exactly what makes the idea of citizen journalism so powerful....The video recording, which Darrow later posted on YouTube and Google Video, prompted more than 300 calls to the small St. George City Police Department. What a perfect use of technology....Technology such as blogs, camera phones and uploaded video features on the Internet gives the public more power in a democratic system, thereby allowing citizens to air dirty laundry that might not have been picked up by the mainstream media. Loose cannon authority figures beware - your inappropriate antics might be coming to an Internet site in the near future."posted by ericb at 9:05 AM on September 28, 2007
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Beverly Earll, 76 - November 12, 2008
Beverly J. Earll, 76, of Gothenburg died Friday, Nov. 7, 2008, at North Platte.
Services were held on Wednesday at 10:30 a.m. at the Evangelical Free Church of Gothenburg with the Rev. Larry Viter officiating. Burial took place at the Gothenburg Cemetery.
Earll was born March 22, 1932, to Albert Lee and Verna Marie (Golden) Harvey at Gothenburg.
She was united in marriage to Kenneth C. Earll on Sept. 8, 1948, at Lexington. To this union, four children were raised—Rodger, Patricia, Roxie and Stacie. Her husband preceded her in death July 20, 1996.
Earll worked at Monroe's of Cozad for 27 years. She was a self-built woman who was very strong and caring for everyone she knew, according to family members.
She enjoyed dancing with Luther Miller of Gothenburg at Senior Centers from North Platte to Lexington and everywhere in between, and would attend up to 15 dances a month, said family members. She also enjoyed gardening and garage sales.
Earll was preceded in death by: her parents, Albert and Verna; a brother, Roy Harvey; sister, Rosie Rhinehardt; her husband, Ken.
?Survivors include: her significant other and best friend, Luther Miller of Gothenburg; her son, Rodger Dale (Kathy) Earll, Sr. of Gothenburg; her daughters—Patricia Ann Cunningham of Gothenburg and Roxie (Tim) Schescke of Richland, WA; four brothers—Lawrence Gugleman, Ron Harvey, Don (Debbie) Harvey, George (Peggy) Harvey and Jim Harvey; two sisters—Dorothy Andrews and Sharon (Fred) Engberg; 11 grandchildren, 26 great-grandchildren, and one great-great-granddaughter.
Memorials are suggested to the Earll Family c/o Blase-Strauser Memorial Chapel, 620 10th St., Gothenburg, NE 69138.
Online condolences may be sent to the family at www.blase strauser.com.
Arrangements have been placed in the care of Blase-Strauser Memorial Chapel of Gothenburg.
Latest Headlines
- Ehmen relative donates relics to local museum
- With help of Gothenburg teen, near-death experience ends OK
- Healthcare concerns
- Resident gets permit for taller fence
- Rural Nebraskans' optimism up this year
- Runners taking it one step at a time
- Gothenburg hitters pound opposing pitchers at Lex Invite


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News » Page 46
in Local Sports
Tillman, Markakis carry Orioles over Mariners
Chris Tillman pitched seven innings of three-hit ball, Nick Markakis hit his first career leadoff homer and the Baltimore Orioles beat the Seattle Mariners 1-0 Sunday.
in Sports
Woods withdraws from Bridgestone
Tiger Woods had to withdraw from the final round of the Bridgestone Invitational today after experiencing more back pain.
in Viral Videos
DMX screams his head off on an amusement park ride
It doesn't matter if you look and talk tough, the candid camera never lies.
in Sports
Letter: Bon Jovi wants Bills to succeed in Buffalo
Jon Bon Jovi says his prospective ownership group wants the Bills to succeed in Buffalo.
in Local Sports
Bells fall to HarbourCats in 11 innings
The Victoria HarbourCats scored four runs in the first inning and withstood a Bellingham comeback to walk-off the Bells 5-4 in 11 innings.
in Local Sports
Quakes beat Sounders 1-0 in Levi's Stadium opener
The San Jose Earthquakes held off the Seattle Sounders 1-0 on Saturday night in the first sporting event at Levi's Stadium.
in Sports
Brooks kicks off Hall of Fame ceremonies
Brooks was the first of the seven-member 2014 class to open the induction ceremony in Canton on Saturday night.
in Local Sports
Former Seahawk Walter Jones inducted into Hall of Fame
Former Seahawk offensive tackle Walter Jones has been inducted into the Pro Football Hall of Fame.
in Sports
Doctors say George faces long rehab process
Paul George's recovery from a gruesome right leg injury could take a year or more, doctors say.
in Local Sports
Locker crisp in Titans scrimmage
The Titans worked for approximately 90 minutes Saturday night as a partial tuneup for their preseason opener, Aug. 9 when they host the Green Bay Packers.
in Local Sports
John Force qualifies No. 1 in Funny Car
John Force raced to his 150th No. 1 qualifying position in Funny Car on Saturday in the NHRA Northwest Nationals.
in Sports
Sergio holds onto lead at Bridgestone
Sergio Garcia has posted a 3-under 67 and leads the Bridgestone Invitational by three shots after three rounds.
in Local Sports
Cano's 3-run HR lifts Mariners over Orioles 6-3
Robinson Cano hit a three-run homer.
in Local Sports
Hart on disabled list, Paxton off DL for Mariners
The Seattle Mariners have placed designated hitter Corey Hart on the 15-day disabled list with a bruised right knee.
in Local Sports
Keane, Gonzales, Marshall miss MLS All-Star game
Galaxy forward Robbie Keane and defender Omar Gonzalez, as well as Seattle Sounders defender Chad Marshall, have pulled out of the Major League Soccer All-Star game against Bayern Munich.
in Local Sports
Locker driven to win in final year of Titans' deal
Wins, not money, is driving Tennessee quarterback Jake Locker as he heads into his make-or-break season in the NFL.
in Local Sports
Seven to Join Hall of Fame in Canton
Seattle Seahawks star Walter Jones and 6 others ready for their gold jackets and enshrinement into the Pro Football Hall of Fame.
in Sports
George suffers serious leg injury in US exhibition
George has undergone successful surgery on his injured right leg and is expected to remain in the hospital for about three days.
This weekend in entertainment history
A look at the Hollywood headlines that made history.


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General Motors Co (GM): Today's Featured Automotive Winner
Editor's Note: Any reference to TheStreet Ratings and its underlying recommendation does not reflect the opinion of TheStreet, Inc. or any of its contributors including Jim Cramer or Stephanie Link.General Motors (GM) pushed the Automotive industry higher today making it today's featured automotive winner. The industry as a whole closed the day up 0.4%. By the end of trading, General Motors rose $0.62 (1.9%) to $32.55 on light volume. Throughout the day, 18,541,614 shares of General Motors exchanged hands as compared to its average daily volume of 28,116,300 shares. The stock ranged in a price between $32.15-$32.88 after having opened the day at $32.29 as compared to the previous trading day's close of $31.93. Other companies within the Automotive industry that increased today were: Supreme Industries (STS), up 4.2%, Monro Muffler Brake (MNRO), up 3.1%, Arctic Cat (ACAT), up 2.7% and Stoneridge (SRI), up 2.5%.
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Department Of Natural Resources
Some Minnesota Lakes Still Have Ice For Opener
Officials expect nearly 500,000 people to head out onto Minnesota's lakes and streams for this weekend's opening of fishing season. The cold winter means some lakes in far northern Minnesota and northeastern Minnesota still have some ice on them. But the ice has been receding fast this past week.
Minn. DNR Launches New App For Anglers
After a long, harsh winter, summer is finally around the corner — at least fishing season is. And now that the Walleye Opener is coming up this weekend, anglers will have a new tool. The Minnesota Department of Natural Resources just launched a new mobile-friendly website Wednesday that includes all of the complicated rules and regulations for each lake, in one easy-to-understand place.
DNR Being Sued For Alleged 'Mismanagement' Of Lake Mille Lacs
In November 1998, Minnesota voters passed a constitutional amendment on the ballot that is meant to preserve the state's storied hunting and fishing heritage.
Want To Try Archery? Climbing? Or Kayaking? The DNR's Got You Covered
Now that one of the worst winters in decades is over, the Department of Natural Resources wants to remind us that summer awaits in Minnesota's State Parks.
Anglers Open Minnesota Trout Fishing Season
After the long, cold, snowy winter it would be hard to blame anyone for avoiding weekend chores and picking up a fishing pole, and that's what thousands of eager Minnesota anglers did on Saturday. The annual trout fishing season got underway Saturday under cloudy, yet mild conditions.
DNR And MDHA Emergency Deer Feeding Program In Full-Swing
While it may appear to be a postcard perfect morning in the woods just north of McGregor, Minn. the long, tough winter has taken a toll on woods and the state's whitetail deer. "There's over three-feet of snow still in the woods," volunteer Dan Guida said.
Minnesota Lawmakers Consider Renaming Asian Carp
The troublesome fish currently known as Asian carp may get a new name in Minnesota over concern that the current one casts people from Asian cultures in a negative light.
Minnesota's Elk Management Plan Up For Revision
Wildlife managers have scheduled a public meeting in northwestern Minnesota to discuss an upcoming revision to the state's elk management plan.
DNR Won't Extend Comment Period On PolyMet Review
Regulators say they won't extend the 90-day comment period for the environmental review for the proposed PolyMet copper-nickel mine beyond March 13.
DNR Streaming Live Video From Metro Eagle Nest
A couple of bald eagles are sitting on eggs in a Twin Cities nest and you can watch it all happen from your computer.
Snowy Owl Photographers Divided Over Baiting Flight Shots
Snowy owls are showing up in large numbers this winter, frequenting areas far from their normal arctic habitat. On a light pole in Ramsey Monday sat a snowy that has become somewhat of a star, posing for all kinds of incredible nature photographs.
DNR: Minn. Moose Population Estimated At 4,350
Wildlife managers have estimated Minnesota's moose population at 4,350. While that's higher than last winter's figure, they say there's been no significant change in the population trend. Lou Cornicelli, wildlife research manager for the DNR, says the new estimate is very close to 2012's estimate of 4,230.
DNR To Hold Public Meetings On SE Minn. Deer Goals
The Minnesota Department of Natural Resources plans to hold two public meetings this month on how best to manage deer populations in southeastern Minnesota.
Minnesota State Park Permit Sales, Visits Rise
Minnesota state parks officials say their efforts to connect people with the outdoors are paying off in permit sales and visits.
Researchers To Collar 52 Adult Moose In NE Minn.
Researchers plan to collar 52 adult moose in northeastern Minnesota starting this week in the second year of a high-tech study to determine why the iconic species is disappearing from the state. The radio collars use GPS to transmit alerts when a moose dies.


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Goldie Irma Lucretia Beres (nee Leranth) of Oak Creek died Oct. 20, 2008, at age 95.
She was born in South Milwaukee on June 20, 1913, to Charles and Barbara (nee Gregus) Leranth. She was united in marriage to Bernard Beres; he preceded her in death in 1978.
She was a highly conscientious employee for 26 years at the South Milwaukee Bucyrus Erie plant. She touched many lives and hearts during her 51 years as a gifted, exuberant Sunday school teacher at Oak Creek Assembly of God Church. Above all, she was a devoted wife and mother.
She is survived by her daughters, Barbara (Gene) Schuster, Betty (Jon) Gueller and Beverly (Pat) Haley; grandchildren, Randy (Lisa) Burk, Beth (Tim) Maxwell, Jill (Todd) Haley-Rose and Sean Haley; great-grandchildren, Jason Burk, Jimmy Maxwell, Keeghan Burk, Joshua Burk, Dylan Maxwell and Summer Rose; the Richard Leranth family; neighbors, Tom and Kathy Ashbaugh; other relatives and friends.
She was preceded in death by her husband, Bernard Beres; son, Bernard Edward; son-in-law, George Burk; granddaughter-in-law, Tammy Burk; parents; brothers and other relatives.
Private funeral services were at Oak Creek Assembly of God Church. Interment was at Forest Hill Memorial Park.
Memorials are suggested to the Hospice of Aurora VNA of Milwaukee or the Oak Creek Assembly of God Church.
The family thanks the staff at Hospice of Aurora VNA of Milwaukee.
Purath-Strand Funeral Home & Crematory handled the arrangements.
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- Two years later, Oak Creek officers honored for efforts in Sikh Temple shooting
- Sikhs celebrate an anniversary of 'healing'
- Chardhi Kala memorial walk/run moves with relentless optimism in Oak Creek
- Oak Creek-Franklin Joint School Board to vote on referendum question
- Oak Creek tree nursery firmly plants itself in diversity
- Oak Creek skate park still a thrill, almost 10 years later
- 'Land fill' paves way for new lakefront road in Oak Creek


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I am a rabid Neal Stephenson fan, and am also currently training for the L.A. Marathon!View all photos and/or videos
The time a lawyer spends giving back through sites like this show passion for the law and compassion for people. Kudos to you for helping others with... more
Elizabeth is very knowledgeable in Patent Law and can explain things that will help you better understand the area. I endorse Elizabeth. Thank you!


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It's always an honor to be asked to participate in something to do with the history of the town one lives in.
As a relative youngster (I've only been here since 1995) it was especially humbling to be asked to part of the "Boulder Conversations with Extraordinary People" Speaker Series. This year's series includes Ceal Barry, Josie Health, Gary Neptune, Bob Sievers, Ann Cooper, Jim Guercio, and Frank Day.
My session is Wednesday, February 12th. The event is happening at the future home of the Boulder History Museum (2205 Broadway, corner of Pine & Broadway). We'll talk about Boulder, how I got here, and what this incredible town means to me.
Grab a ticket here - all ticket sales go to running the event and the museum, nothing goes to me.
For the record, I'm not old enough to have come to Boulder by train, although I would look fantastic for my age if I did.
The Entrepreneur's Foundation of Colorado, the Living Green Network, and Mocavo are hosting a roofdeck bash on Halloween to benefit first-responder families and local farms devastated by the recent Boulder-area flood. Let's rally the entrepreneurial community together and raise some money for those in need. I'll be there to support the cause and would love for you to join me.
Cliff and the Mocavo gang are opening a one-night-only bar in downtown Boulder in the name of charity. Anyone who's been to Boulder on Halloween knows it tends to be a pretty wild night, especially when it's on a Thursday. Between the gong for donation milestones and the flatscreen broadcasting the money raised, it should make for a fun event. Donations made by employees of local companies will also optionally join a company leaderboard for some healthy competition.
Existing sponsor list includes KKO, Silicon Valley Bank, and Goldman Sachs. More sponsors are welcome – a restaurant sponsor would be great.
Register for the free event at EventBrite (link to https://halloweenfloodrelief.
I was going to blog about the Yesware $13.5 million financing but I've been buried in Denver Startup Week so I'll do that tomorrow.
I've continued to be emotionally distracted by all the devastation around Boulder from our recent floods. I've gotten a ton of emails from all over the world in support as well as some meaningful financial contributions adding on to the $100,000 my partners and I just gave to the Entrepreneurs Foundation of Colorado to provide direct support for the flood victims.
Amy's assistant Naomi hiked up to our house in Eldorado Canyon today to finally check on our house there. The house is fine, but there is damage to a bunch of our property. At some intellectual level it's incredible to see the power of water. At some other level it's emotionally distressing. The picture above is our meadow. And yes – the crevasse is "new" – so we have a new creek in our meadow.
Then – there's the lower part of our driveway – well, at least what used to be a driveway.
And then there's the road through Eldorado State Park, which no longer works as a road.
We are all ok and have plenty of resources to deal with this. So we've turned most of our energy to helping our friends, neighbors, and extended Boulder County community deal with the destruction the floods have caused. But it's really amazing to see the power of mother nature unleashed.
Today, my partners at Foundry Group and I are contributing $100,000 to the Entrepreneurs Foundation of Colorado (EFCO) to help with the Boulder Flood Relief Effort. This is our second gift to the EFCO – we previously contributed a portion of our carry across all of our funds.
The floods in Boulder and the surrounding area the past week have been devastating. I went for a run last night around town just to get a feel for things – the water is still at dangerously high and fast levels in Boulder Creek and the damage near the creek in downtown is visible. I smelled smells that I've never smelled in Boulder before and saw water in places it simply didn't belong.
But downtown Boulder is quickly getting back to normal. That's not the problem. If you've ever been to Boulder, you know we are surrounded by incredible mountains. It's part of the magic of the place, but also part of the challenge. A friend told me recently, "think of the mountains as giant slanted roofs and Boulder as the basement of the house."
There are two natural forces here that can be massively destructive. The first, which have made the news the past few years, are wildfires. Amy and I have endured these for the past 17 years – we've been evacuated from our house twice, once for three days during my brother's wedding. The massive Lefthand Canyon Fire destroyed a huge neighborhood. Awful, terrifying stuff.
But that just set us up for what looks like the real disaster. The entire mountain area around Boulder is wrecked. Roads are destroyed. Towns in the "basement" – including Lyons – are literally wiped off the map. Major parts of Longmont are now submerged. The water ran downhill, destroying everything in its path as gravity did it's magic, and then just sat at the bottom wherever it ended up.
My partners and I are lucky. None of our lost our houses. We all have roofs over our heads. And we have plenty of resources.
But many of our friends and neighbors were not so lucky. The stories are endless – the friend who lost her house and has no place to live. Another friend who made a mad dash off the mountain with his family and has no idea what the status of his home is. The entrepreneur who worked out of his basement, which is now a swimming pool. The business owner who's office is now cut in half – and destroyed – by a mudslide. The tech leader who recently had a major back injury, just got out of the hospital, and had to evacuate his house. The people stuck up in the mountains who can't get out. And the people stuck down in the foothills that also can't get out.
The magnitude of this hit me yesterday afternoon when I heard estimates of $100m – $150m to fix the "infrastructure damage." I have no idea what that really means, but for a region of a couple of hundred thousand people, knowing the range is low, and it's only "infrastructure", this is going to be a long, hard mess to dig out of.
I've always felt a strong responsibility to the community I call home. Boulder has been and continues to be very good to me. And it's my responsibility, especially in times like this, to be good back. This is not the only financial support we'll be giving to the Boulder Flood Relief Effort. In addition, we'll give plenty of functional support. But it's a step – and one we hope can have direct impact.
My partners and I encourage every entrepreneur in the area who has had a meaningful financial success to consider giving something through EFCO to the Boulder Flood Relief Effort. If you are an entrepreneur who hasn't yet had a financial success, consider joining EFCO and contributing 1% of the equity in your company today, to help build the endowment for the future. And, if you are a venture capitalist or an angel investor in – or with investments in – the Boulder area, please consider joining EFCO and contributing directly to the relief effort today. Just email me and I'll get you connected.
Finally, if you are a reader and part of the Feld Thoughts community and you want to help out, please contribute directly to the Foothills Flood Relief Fund. We greatly appreciate any support you can give.
In 2007 when I co-founded Entrepreneurs Foundation of Colorado with a bunch of folks our mission was to create wealth that we could give back to the community that has been the foundation for so many of our entrepreneurial endeavors. We envisioned that this would be a long term build, just like the creation of many of the companies we are involved in. Over the last six years we've now generated gifts of over $500,000 that have gone back directly to our community, with the most recent one being from Intense Debate, a company that went through Techstars Boulder in 2007.
Today my friends from GoodApril, who went through the Techstars Boulder 2013 program, just gave $20,000 to EFCO to help with the victims of the massive Boulder-area floods. In addition, Eric and Kim Norlin from the Defrag Conference offered to give $250 to EFCO for everyone who register for Defrag this week.
I asked Mitch Fox and Benny Joseph from GoodApril to write up their thoughts on why they did this. It follows.
A month ago, the sun was shining in Boulder, Colorado as my co-founder, Benny Joseph, and I as we announced the biggest news of our lives. Our startup, GoodApril, had been acquired by Intuit (maker of TurboTax) in the final days of the TechStars Boulder accelerator program.
In this last week, rain clouds have overwhelmed Boulder and several other Front Range towns. We've been distressed by the devastation, and inspired by the Boulder community's resilience.
While we were a part of the Techstars program, Benny and I pledged our support to the Boulder community through the Entrepreneurship Foundation of Colorado (EFCO), a program that enables startup founders to give back through the contribution of equity in their companies. In light of the flood and its impact on Boulder, we have agreed to accelerate that gift.
Startups cannot succeed in a vacuum. They are as much the product of the sweat and tears of their founders as they are of the mentors, customers, and investors that shape them.
This summer, we experienced the power and generosity of the Boulder community as we built GoodApril. The Techstars program matched us with phenomenal local business leaders like Vijay Bangaru, JP O'Brien, and Brett Jackson, who helped us find both the strengths and weaknesses in our business plan. We were welcomed into Boulder's tech scene, and quickly connected with dozens of potential customers who shared their expectations and excitement for our product. As we progressed, the Techstars leaders, especially Luke Beatty, David Cohen, and Brad Feld, guided us through many tough decisions, including finally whether to accept Intuit's acquisition offer.
We are extremely appreciative for what Boulder has given us, so we hope our donation to EFCO can help the community recover from this flood.
Thank you Boulder. Here's to seeing that sun shine again,
Mitch Fox and Benny Joseph


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Architectural Summit draws architects for credits
June 7, 2011
Tim Nass presenting "Code Considerations in Fire Rated Glass" by Safti First
Safti First, San Francisco, hosted its second Architectural Glazing Summit on June 2 in New York City. About 80 architects and specifiers attended the half-day educational conference to learn about advances in glazing technology and design. Safti First, Wausau Window and Wall Systems, W&W Glass LLC and Firestone/UNA-CLAD each presented an AIA-registered program at this event, giving attendees the opportunity to earn multiple learning credits. The presenting companies and also Schott North America had tabletop displays with additional information for attendees.
Topics included code considerations in fire-rated glass, structural glazing innovations, window selection and sustainability, and metal panel systems. Click here for more detailed information on the presentations.


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Is Paul Menard gay or straight?
Here you find the sexual orientation of Paul Menard. Do you think Paul Menards sexual nature is incorrect? Inform us about the correct sexual orientation.
The sexual orientation of Paul Menard Is heterosexual / straight
Do you like Paul Menard?
gay-o-meter/gaydar for Paul Menard
According to 0 visitors Paul Menard is 0% gay.
However, the average gay-rating on gay-or-straight.com is 69%, which means Paul Menard is very straight in comparison to other celebrities on this website.
Please vote! How gay is Paul Menard?
|< Louis Menand
|Réal Ménard >


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(EDITOR'S NOTE: This is one in a series of articles on the continuing spread of pine wilt disease.)
Great Bend got a pat on the back when a state official met with the county this week.
The work that the city has done to respond to the arrival of a serious tree disease has been a good example of how the disease can be contained.
Unfortunately, it will only be slowed, because there is no cure, and introduced pine trees across the state are succumbing to pine wilt disease, District Forester Jim Strine, Hays, told the Barton County Commission ...
** Subscribers Log in to read this full article.


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Roger is a seriously underrated Disney fella!
Roger is a seriously underrated Disney fella!
Edna does not approve of Philip's extravagant cape
Truth about life
Princess inspired Tiaras and Crowns
(Source: bforbel.com)
It looks like Philip is about to hulk out
(Source: loveholic198)
New Sleeping Beauty Vinlymation! This is one series I just have all of!
Guess who I'm going to be for Halloween? I'm so excited about making this dress!
Hollywood Studios is a Hidden Mickey. The whole park is a Hidden Mickey!!
Busted from Adrien on Vimeo (with the sound).
Fan art animation I did for fun and for free as a tribute to Aladdin & Tangled.
I love this! Check it out


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Sam Rolley Archive
Sam Rolley Staff writer Sam Rolley began a career in journalism working for a small town newspaper while seeking a B.A. in English. After learning about many of the biases present in most modern newsrooms, Rolley became determined to find a position in journalism that would allow him to combat the unsavory image that the news industry has gained. He is dedicated to seeking the truth and exposing the lies disseminated by the mainstream media at the behest of their corporate masters, special interest groups and information gatekeepers. Email this author.
School Board Victimizes 3-Year-Old Deaf Boy
A Nebraska school district is telling the parents of a deaf 3-year-old boy that the sign language for his name, Hunter Spanjer, looks too much like a gun and must be changed. Hunter uses Signing Exact English (S.E.E.), the standard sign language, for his name.
Gold Still A Sound Investment
Ahead of the annual monetary policy gabfest at Jackson Hole retreat in Wyoming, members of the Board of Governors of the Federal Reserve have been quietly hinting that another round of stimulus or "quantitative easing" (inflationary money printing) may be on the horizon.
Surviving The Storm
With the prospect of Hurricane Isaac following a similar trajectory as Hurricane Katrina did seven years ago nearly to the day and as thousands have been urged to evacuate affected areas, it is a good time for preppers to take an opportunity to re-evaluate their plans for the unexpected.
Rand Paul Wants Legal Hemp
Senator Rand Paul (R.-Ky.) is currently working to do away with Federal laws that classify industrial hemp in the same way as marijuana, a move that he says would have lasting economic benefits.
Golden Platform Additions For GOP
According to CNBC, drafts of the Republican Party platform, which will be adopted at the convention this week, include provisions for setting up a commission that would investigate the effects of a return to the gold standard.
Stimulus Likely Amid Election Heat-Up
Get ready for another round of fiat money production courtesy of the Federal Reserve; the central bank says if economic data doesn't turn around, it will fire up the presses "fairly soon."
Picket Fences Are Long Gone
The American middle class is shrinking rapidly, and those holding on to the vestiges of the socioeconomic bracket once exemplary of the American dream now have it worse than ever before.
Ruby Ridge Tactics Now Modus Operandi?
This week, two decades ago, Americans were watching reports of the horrific escalation of the events that occurred in Ruby Ridge, Idaho, where agents of the Federal government terrorized and killed members of Randy Weaver's family after he failed to appear in court on a charge of selling shotguns that were slightly too short to an undercover Federal agent.
Antibiotics Can Make Kids Fat
Researchers are exploring a new culprit in the ever-growing childhood obesity epidemic: rampant use of antibiotic drugs to treat minor childhood illness. Antibiotics changed the makeup of gut bacteria.
Obama's Media Strategy: Control Questions
President Barack Obama has been avoiding the White House press corps in a bid to avoid taking hard-hitting questions in the middle of an election cycle, but he is giving interviews to reporters from local news organizations throughout the Nation.


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Our films are unique, with use of glide track, steadicam and professional audio which helps us produce our Hollywood signature style.
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For us, your photography and cinematography is so much more than just beautiful photos and exquisite video. It's about bringing your love story to life along with the smiles and emotions of your day.
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Check Availability
We'd love to learn more about you and your journey together and those details that makes your day special. Click the button to fill out our request form or call (914) 443-3678.


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Madrid Shopping
Custo Review
Brothers Custodio and David Dalmau are the creative force behind the success of this chain, whose eye-catching T-shirts can be found in the closets of such stars as Madonna and Julia Roberts. They have expanded their collection to incorporate pants, dresses, and accessories, never relinquishing the traits that have made them famous: bold colors and striking graphic designs.
- Address: Mayor 37, Sol, Madrid, 28013 | Map It
- Phone: 91/354–0099
- Location: Sol and Palacio
Contact Information
Other locations
- Serrano 16, Salamanca, Madrid, 28001, 91/577–2663
- Fuencarral 29, Chueca, Madrid, 28004, 91/360–4636
Fodorite Reviews
Be the first to review this property


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My first feeling about Stockholm is that it's really expensive and it's hard to find a cheap place to stay. Lodge 32 seems to be a mix of both where it was a great location and a decent price. I spent about three days there and the location started to work with me as the metro is very close. The... More
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Hotels.com, Priceline, Tingo, BookingOdigeoWL, HostelBookers, Agoda, HostelWorld and Venere so you can book your Lodge32 reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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Family-Owned Home Mortgage Loan Company. Call Us Now for a Consult.
Fast, Secure, & Easy. Apply Online or In Store. Get Instant Approval.
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How to Reduce Credit Card Debt
The Official MoneyMutual is Endorsed by Montel. Get up to $1,000!
One of the most important steps to financial freedom is to reduce credit card debt. There are a number of different ways you can reduce credit card debt, but essentially it all boils down to the same thing: making a plan, which involves a budget, and sticking to the plan.
The Debt Snowball Method
The debt snowball method is a way to reduce credit card debt made popular by Dave Ramsey, a motivational speaker who provides personal finance advice on his television and radio program. The Debt Snowball plays on the psychological factor associated with your debt, creating a debt management system that Ramsey believes people are more likely to stick to.
In order to reduce credit card debt using the debt snowball method, you begin by listing your debts in order from the lowest amount owed to the highest amount owed. You will pay the minimums on each card. Then, any extra money you are able to find, you put towards the card with the lowest balance. If you find extra cash- a tax refund, or a rebate check for example, you will also pay those towards that card. Some people call these little cash payments "snowflakes."
When you finish paying off the smallest balance, you then will direct all of your attention towards the card with the next largest balance. The amount of money you were paying monthly towards the paid off card gets added to what you were paying originally on this new card. Thus, you are paying more then the minimum do, and also "snow flaking" or sending extra payments in as you have cash.
Use this method until you have paid off all of your credit cards. The more extra money and payments you are able to find, the faster you will be able to reduce credit card debt and be on your way to financial freedom.
The Debt Avalanche Method
Some people do not like Dave Ramsey's method because it means you pay more interest over the long run, since you are not paying your debts off in order of interest rate but instead in order of smallest debt to largest debt. While the Dave Ramsey method plays on the psychology of debt, pure mathematics suggests that the Debt Avalanche may be the best option.
When you use the debt avalanche, you pay off your debts from the highest interest rate down to the lowest interest rate. This means sending as much money as you can to the card or debt that charges you the most for the privilege of having the debt.
Finding Ways to Reduce Credit Card Debt
Regardless of the debt repayment method you choose, the key to finding ways to pay off your debt is to practice smart spending habits. This means living below your means and not incurring any new debt. It also means finding wiggle room in your budget to pay extra. If you pay only the minimums, it may take you decades to reduce credit card debt and you may find yourself paying large amounts of interest. When you make a commitment to reduce credit card debt, cut unnecessary spending and put that extra cash towards repaying debt. When you are debt free, you will be glad you did.


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1-Day Acuvue Moist 30 pack
1-Day Acuvue Moist 90 pack
1-Day Acuvue Moist for Astigmatism 30 pack
1-Day Acuvue TruEye 90 pack
Acuvue 1 Day
Acuvue 2
Acuvue Advance
Acuvue Advance for Astigmatism
Acuvue Advance Plus 6 pack
Acuvue Advance Plus 24 pack
Acuvue Oasys 6 Pack
Acuvue Oasys 12 Pack
Acuvue Oasys 24 Pack
Acuvue Oasys for Astigmatism
Acuvue Oasys for Presbyopia
Air Optix Aqua
Air Optix Aqua Multifocal
Air Optix Colors
Air Optix for Astigmatism
Air Optix Night & Day Aqua
Optima 38/SP
Optima Toric
PureVision 2 for Presbyopia
PureVision 2 HD
PureVision 2 HD for Astigmatism
PureVision Multi-Focal
PureVision Toric (PureVision For Astigmatism)
SofLens 1 Day Toric for Astigmatism 30pack
SofLens 38
SofLens Daily Disposables 90 pack
SofLens Multifocal
SofLens Toric (SofLens For Astigmatism)
Dailies AquaComfort Plus 30 pack
Dailies AquaComfort Plus 90 pack
Focus DAILIES Progressives 30 pack
Focus Dailies AquaComfort Plus Multifocal 30pk
Focus Dailies AquaComfort Plus Multifocal 90pk
Focus Dailies AquaComfort Plus Toric 30pk
Focus Dailies AquaComfort Plus Toric 90pk
Focus DAILIES 30 pack
Focus DAILIES 90 pack
Focus DAILIES Total 1 30 pack
Focus DAILIES Total 1 90 pack
Focus DAILIES Toric 30 pack
Focus DAILIES Toric 90 pack
FreshLook Colorblends
FreshLook Colors
FreshLook Dimensions
Freshlook Lite Tint
FreshLook ONE-DAY
Biofinity Multifocal
Biofinity Toric
Biofinity XR
Proclear 1 Day 90pk
Proclear 1 Day Multifocal 30pk
Proclear Multifocal
Proclear Multifocal Toric
Proclear Toric XR
Proclear EP
Proclear Toric
Proclear 1 Day 30pk
Lens Case/Cleaner - Bold Wire
Lens Case/Cleaner - Little Feet
Lens Dual Case - Luxurious
Contact Lens Case - Traveler
Contact Lens Case - Smiley
VZ CASTAWAY Frostbyte Black Pink
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VZ ELMORE Frostbyte Black Blue
VZ SIDEPIPE Tortious
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These lenses are custom made therefore it will be 2-3 weeks before the lenses are shipped.
*Based on price per box after purchasing a year supply from May 1, 2014. Includes all fees such as process, tax, and handling.
Don't let astigmatism keep you from knowing the freedom that come with wearing contact lenses. Preference Toric contacts work with the abrupt curving of the lens or cornea of your eye to give you superior vision correction and all day comfort. Ideal for first time lens wearers, these Preference Toric contact lenses are flexible, durable, and some of the lowest maintenance lenses on the market.
Preference Toric contacts are developed by CooperVision with Tetrafilcon, a lens material to not only produce a more durable lens, but also a deposit-resistant contact that promotes greater comfort and healthier eyes. Preference Toric contacts are monthly disposable lenses
, and are slightly tinted for ease of handling. Each box of Preference Toric contacts contains four contact lenses individually packaged a buffered saline solution.
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Will Preference Toric contact lenses support my high level of astigmatism?
Absolutely! The Preference Toric lenses are designed specifically to ensure maximum comfort for every degree of astigmatism. If you're tired of wearing glasses to avoid irritating your astigmatism, these contact lenses offer a natural, comfortable alternative even with the highest degree of astigmatism. For a similar product, ask your doctor about Acuvue 1 Day Moist for Astigmatism.
Can I sleep with my Preference Toric lenses in my eyes?
Proper care procedures recommend removing and cleaning your Preference Toric lenses before going to bed each night. Sleeping with Preference Toric lenses in your eyes will most likely cause dryness, redness and general discomfort. If prolonged discomfort occurs, please contact your eye doctor immediately.
I live an active lifestyle. Can I wear Preference Toric lenses day in and day out comfortably?
Preference Toric lenses are manufactured to ensure durability, flexibility and comfort throughout the wearing cycle. Each lens lasts about 3 months before it is recommended that you switch to a new pair. With proper care and handling you can wear these lenses daily without trouble for 2 to 3 months at a time.
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text:
I get a phone call.
'Have you seen what's under the windscreen wiper of your car?' Pelly whispers.
'No,' I say, phone under chin as I walk out to the front of my house to have a look.
'Well, you might want to,' she says.
It's only another empty wrapper of a bondage starter kit, devoid of its advertised contents of whip, nipple clamps and chain. I extract it, quickly, before anyone else sees it. I look around to make sure no-one is filming the scene.
Until I find out who has placed it there, everyone is under suspicion.
That's about it.
Love Maddie x
Friday, 18 March 2011
My starter kit for ten
Posted by Maddie Grigg at 4:46 pm
Labels: bondage starter kit, nipple clamps, whips
7 comments:
You realise that you're going to get all kinds of undesirable hits with labels like that!ReplyDelete
But will they get through my spam detector...? It was either that or 'windscreen wiper' or 'phones under chin'. Tricky really. ;0)ReplyDelete
So Pelly found both of them? I'm seeing a pattern. :)ReplyDelete
I'll bet you were fit to be tied... ;)
The Ick Factor is huge here. I, too, am seeing a pattern.ReplyDelete
I'm not sure I'm getting it, but, all right, I'll bite.ReplyDelete
- Anonymous21 March 2011 10:17
who could of done such a thing?ReplyDelete
Ought this blog to be classed as an Adult site - am only joking :)sReplyDelete
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(Source: damnafricawhathappened, via territorialcreep)
Fudge recipe on a headstone
I feel like I should make this just to be able to say a dead person taught me how to make it. Maybe I'll do it for Halloween.
I desperately hope that she spent her entire life telling people that they could have her fudge recipe "over my dead body."
That last comment is absolutely worth reblogging.
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Sometimes the heart doesn't know what it wants until it finds what it wants.
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text:
Lewis Moody factfile
ESPNscrum Staff
March 6, 2012
Lewis Moody will be fondly remembered by Tigers fans © Getty Images
Lewis Moody has experienced a stunning career - ESPNscrum looks back at some key moments.
1978: Born June 12 in Ascot, Berkshire.
1996: After coming through the ranks at Leicester Tigers, makes his senior debut against Boroughmuir while still attending Oakham School.
1997: A member of the England Colts side that won the Madrid Sevens.
1999: Wins the first of seven Premiership titles.
2000: Retains Premiership title with Leicester.
2001: Wins the first of two Heineken Cups with the Tigers, before going on to make his senior England debut against Canada on June 2.
2003: March - Part of England's Grand Slam-winning Six Nations squad.
October/November - Plays in all seven matches as England win the World Cup, including winning the lineout that led to Jonny Wilkinson kicking the winning drop goal in the final against Australia. Is awarded an MBE in the New Year Honours.
2005: Wins three caps for the British & Irish Lions on their tour of New Zealand.
2007: After missing the Six Nations through injury, Moody wins 50th international cap in England's World Cup quarter-final win over Australia. Features in all seven matches for England at World Cup, including the defeat to South Africa in the final.
2008: Ruptures an Achilles tendon in the first match of the Six Nations against Wales. Misses a total of nine months after also undergoing ankle and hip surgery.
2009: Breaks his ankle prior to Six Nations but returns in time for the November internationals.
2010: Captains England for the first time in a Six Nations clash with France. Leaves Leicester after 14 seasons and over 200 appearances. Signs a three-year deal with Bath.
2011: January - A knee injury rules Moody out of the Six Nations.
October - Becomes only 16th player to make over 70 appearances for England in a World Cup victory over Scotland, but England's tournament is dogged by controversy and they ultimately crash out in the last eight against France.
October 23 - Announces retirement from international rugby after 71 caps and nine tries for his country.
December 7 - Expected to be out of action for 10 to 12 weeks after undergoing shoulder surgery. The injury was sustained during Bath's 16-7 Aviva Premiership defeat to Worcester on November 25 - only Moody's third appearance for Bath since returning from the World Cup.
2012: March 6 - Announces retirement from all rugby with immediate effect.
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