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Summary: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
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Publications272 found, 100 shown here
- In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysinHui Huang
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
Neurotoxicology 32:300-6. 2011..b>Neprilysin (NEP), a rate-limiting catabolic peptidase is involved in Aβ metabolism in vivo...
- Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolismGillian I Rice
Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
Biochem J 383:45-51. 2004..cleavage by full-length human ACE, the separate N- and C-domains of ACE, the homologue of ACE, ACE2, and NEP (neprilysin)...
- Metabolic regulation of brain Abeta by neprilysinN Iwata
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako shi 351 0198 Japan
Science 292:1550-2. 2001..We examined the role of neprilysin, a candidate Abeta-degrading peptidase, in the metabolism using neprilysin gene-disrupted mice...
- Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapsesEfrat Abramov
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Nat Neurosci 12:1567-76. 2009....
- Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature deathMalcolm A Leissring
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Harvard Medical School, Boston, MA 02115, USA
Neuron 40:1087-93. 2003..Here we show that transgenic overexpression of insulin-degrading enzyme (IDE) or neprilysin (NEP) in neurons significantly reduces brain Abeta levels, retards or completely prevents amyloid plaque ..
- Neutral endopeptidase protein expression and prognosis in localized prostate cancerIman Osman
Department of Urology, New York University Cancer Institute, Kaplan Comprehensive Cancer Center, New York, New York, USA
Clin Cancer Res 10:4096-100. 2004..We investigated whether decreased NEP expression in localized prostate cancers is associated with prostate-specific antigen (PSA) relapse after radical prostatectomy...
- Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancerVeronique Maguer-Satta
Universite de Lyon, Lyon, F 69007, France
Stem Cells 29:389-96. 2011..This highlights the importance of understanding the role of CD10 in cancer SC. We will review the characteristics, main functions, and mechanism of action of CD10. Finally, we will review its clinical use and involvement in cancer...
- Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer diseaseNikolai D Belyaev
Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK
EMBO Rep 10:94-100. 2009..domain of the amyloid precursor protein (AICD) regulates expression of the Abeta-degrading metalloprotease, neprilysin (NEP)...
- Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patientsManuel D Gahete
Department of Cell Biology, Physiology and Immunology, University of Cordoba, and Instituto Maimónides de Investigación Biomédica de Córdoba, Cordoba, Spain
J Alzheimers Dis 20:465-75. 2010..real-time PCR the mRNA levels of SST/CST, their receptors (sst1-5 and DA receptors (drd1-5) in addition to neprilysin (a SST-regulated enzyme involved in Abeta degradation) in three regions of the temporal lobe, one of the ..
- Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesiclesJean Luc Gatti
Equipe Gamètes Males et Fertilité, URM 6175 INRA CNRS Université de TOURS Haras Nationaux, Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique de Nouzilly, Monnaie 37380, France
Biol Reprod 72:1452-65. 2005..proteins were identified and grouped into i) membrane-linked enzymes, such as dipeptidyl peptidase IV (DPP-IV), neprilysin (NEP), phosphodiesterase-I (E-NPP3), and protein G-beta; ii) vesicle-associated proteins, such as lactadherin (..
- Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesK Shirotani
Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
J Biol Chem 276:21895-901. 2001..1-42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and cloned neprilysin-like peptidase (NEPLP) alpha, NEPLP beta, and NEPLP gamma cDNAs...
- Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic miceLori Lebson
Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
J Neurosci 30:9651-8. 2010..weekly infusions of the CD11b+ bone marrow cells transfected with a genetically engineered form of the protease neprilysin completely arrest amyloid deposition in an aggressively depositing transgenic model...
- Metabolism of amyloid-beta peptide and Alzheimer's diseaseNobuhisa Iwata
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Pharmacol Ther 108:129-48. 2005..b>Neprilysin is a rate-limiting peptidase involved in the physiological degradation of Abeta in the brain...
- Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidonC Oefner
Pharma Preclinical Research, F Hoffmann La Roche Ltd, Basel, CH 4070, Switzerland
J Mol Biol 296:341-9. 2000..The inhibitor is bound to one side of this cavity and its binding mode provides a detailed understanding of the ligand-binding and specificity determinants...
- Prognostic impact of germinal center-associated proteins and chromosomal breakpoints in poor-risk diffuse large B-cell lymphomaGustaaf W van Imhoff
Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Clin Oncol 24:4135-42. 2006....
- Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancerStephen J Freedland
Department of Urology, UCLA School of Medicine, Los Angeles, CA 90095 1738, USA
Prostate 55:71-80. 2003....
- Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic miceWilliam J Meilandt
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
J Neurosci 29:1977-86. 2009..Overexpression of the Abeta-degrading enzyme neprilysin in brains of human amyloid precursor protein (hAPP) transgenic mice decreases overall Abeta levels and amyloid ..
- Chemosensitization of androgen-independent prostate cancer with neutral endopeptidaseMakoto Sumitomo
Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
Clin Cancer Res 10:260-6. 2004..We investigated whether neutral endopeptidase (NEP) could augment chemosensitivity to anticancer drugs by promoting protein kinase C (PKC)delta-mediated mitochondrial apoptosis in prostate cancer (PC) cells...
- Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growthA Horiguchi
Urologic Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, NY 10021, USA
Cancer Gene Ther 14:583-9. 2007b>Neprilysin (neutral endopeptidase, NEP) is a cell surface peptidase whose expression is lost in approximately 50% of prostate cancers (PC)...
- CD10 and CD34 in fetal and adult human hair follicles: dynamic changes in their immunohistochemical expression during embryogenesis and hair cyclingE Poblet
Department of Pathology and AECC Research Unit, Hospital General Universitario de Albacete, Albacete, Spain
Br J Dermatol 159:646-52. 2008..CD10 and CD34 have been detected in both epithelial and mesenchymal components of anagen human hair follicles...
- Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brainNobuhisa Iwata
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
J Neurosci 24:991-8. 2004..Here, we report on the catabolic mechanism of Abeta at the presynaptic sites. Neprilysin, an Abeta-degrading enzyme, expressed by recombinant adeno-associated viral vector-mediated gene transfer, was ..
- Circulating neprilysin clears brain amyloidYinxing Liu
Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, KY 40536 0509, USA
Mol Cell Neurosci 45:101-7. 2010The use of the peptidase neprilysin (NEP) as a therapeutic for lowering brain amyloid burden is receiving increasing attention...
- Effect of sodium valproate administration on brain neprilysin expression and memory in ratsNatalia N Nalivaeva
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
J Mol Neurosci 46:569-77. 2012..In the healthy brain, a group of amyloid-degrading enzymes including neprilysin (NEP) maintain Aβ levels at physiologically low concentrations but, with age and under some pathological ..
- Oxidized neprilysin in aging and Alzheimer's disease brainsDeng Shun Wang
Department of Neuroscience and Pathology Neuropathology, Mayo Clinic, Jacksonville, FL 32224, USA
Biochem Biophys Res Commun 310:236-41. 2003..b>Neprilysin (NEP) is a major enzyme for degradation of Abeta and changes in amount or activity of NEP may play a role in ..
- Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidaseR Zheng
Department of Urology, Urologic Oncology Research Laboratory, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
Oncogene 25:5942-52. 2006..This work also identifies members of this signaling pathway as potential targets for rational pharmacologic manipulation of neuropeptide-stimulated migration of PC cells...
- Neprilysin, obesity and the metabolic syndromeK F Standeven
Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
Int J Obes (Lond) 35:1031-40. 2011b>Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism...
- Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sectionsSuzuko Moritani
Department of Pathology, Shiga University of Medical Science, Seta tsukinowa cho, Ohtsu, Japan
Mod Pathol 15:397-405. 2002..Combination of CD10 and SMA will provide more sophisticated information about presence or absence of myoepithelial cells in confusing breast lesions...
- Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to AktMartin Siepmann
Department of Neurology, Molecular Cell Biology, University of Bonn, Bonn, Germany
PLoS ONE 5:. 2010b>Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction...
- Neprilysin-2 is an important β-amyloid degrading enzymeDaniel Hafez
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
Am J Pathol 178:306-12. 2011..The Aβ-degrading enzyme neprilysin (NEP) is the best known target of these inhibitors...
- Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?Julie A Carson
Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, UK
J Neurochem 81:1-8. 2002..Recent attention has focused on members of the neprilysin (NEP) family of zinc metalloproteinases in amyloid metabolism...
- Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body diseaseWalter Maetzler
Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
J Alzheimers Dis 22:933-8. 2010..b>Neprilysin (NEP) is an Aβ-degrading protein found at presynaptic terminals and in body fluids...
- Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responsesNaoko Morisaki
Kao Biological Science Laboratories, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321 3497, Japan
J Biol Chem 285:39819-27. 2010..As there are similarities in the molecular weights and inhibitory profiles of HSF elastase and neprilysin (neutral endopeptidase 24...
- Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathyMélanie Carpentier
Departement de Biochimie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
J Neuropathol Exp Neurol 61:849-56. 2002Molecular, genetic, and pharmacological studies have shown that neprilysin (also called NEP) catabolizes amyloid beta peptides (A beta) in healthy conditions...
- Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severityJames Scott Miners
Dementia Research Group, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
J Neuropathol Exp Neurol 68:902-14. 2009Experimental reduction of neprilysin (NEP) or insulin-degrading enzyme (IDE) in vivo exacerbates beta-amyloid accumulation in the brain...
- Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer diseaseYinxing Liu
Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, Kentucky, USA
Mol Ther 17:1381-6. 2009b>Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades the amyloid beta (Abeta) peptides believed to be involved in the etiology of Alzheimer disease (AD)...
- Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacityPetra A B Klemmt
Nuffield Department of Obstetrics and Gynaecology, The Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
Fertil Steril 85:564-72. 2006..To evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis...
- Neprilysin gene transfer reduces human amyloid pathology in transgenic miceRobert A Marr
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 23:1992-6. 2003..b>Neprilysin has recently been implicated as a major extracellular Abeta degrading enzyme in the brain...
- A human postnatal lymphoid progenitor capable of circulating and seeding the thymusEmmanuelle M Six
Institut National de la Sante et de la Recherche Medicale INSERM, U768, 75015 Paris, France
J Exp Med 204:3085-93. 2007..Moreover, they belong to the most immature thymocyte population. Collectively, these findings unravel the existence of a postnatal lymphoid-polarized population that is capable of migrating from the BM to the thymus...
- Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric formHyoe Kanemitsu
Department of Neuroscience, Graduate School of Medicine Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
Neurosci Lett 350:113-6. 2003..Here we studied neprilysin, a putative proteolytic enzyme for Abeta, and found that it degraded not only monomeric but also oligomeric ..
- Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brainSuqing Wang
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
J Neurochem 115:47-57. 2010..The major Aβ-degrading enzymes are neprilysin (NEP), insulin-degrading enzyme (IDE), and endothelin-converting enzyme (ECE-1)...
- Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysinLingLing Yang
Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan 250012, Shandong, China
J Pharm Pharmacol 61:375-80. 2009..Recent evidence has shown that neprilysin (NEP) is the rate-limiting enzyme in the Abeta degradation in the brain. Ginseng, the root of Panax ginseng C.A...
- Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors: an immunohistochemical comparison of 34 casesP G Chu
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Mod Pathol 14:465-71. 2001..We conclude that in combination with SMA, MSA, and desmin, CD10 is a useful immunohistochemical marker in the differential diagnosis of ESS versus UCL or ULS...
- Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's diseaseHanjun Guan
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
J Neurosci Res 87:1462-73. 2009..a novel strategy for lowering amyloid burden in the brain by peripherally expressing the Abeta-degrading enzyme neprilysin on leukocytes in the 3xTg-AD mouse model of Alzheimer's disease...
- CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lungM A Shipp
Department of Medicine, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 88:10662-6. 1991..Since SCCa of the lung occurs almost exclusively in cigarette smokers and cigarette smoke inactivates CD10/NEP, decreased cell surface CD10/NEP enzymatic activity may be causally related to the development of SCCa of the lung...
- CD10 is a marker for normal and neoplastic endometrial stromal cellsToshihiko Toki
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
Int J Gynecol Pathol 21:41-7. 2002..These data suggest that diffuse CD10 staining is characteristic of normal and neoplastic endometrial stromal cells, unless they are decidualized...
- HIV-1 Tat inhibits neprilysin and elevates amyloid betaHans C Rempel
Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
AIDS 19:127-35. 2005..lengthened the life expectancy of individuals infected with HIV-1, we investigated the affect of HIV-1 Tat, a viral transactivating transcription factor, on Abeta degradation in the brain by neprilysin (NEP), a neuronal endopeptidase.
- Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradationTakashi Saito
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Nat Med 11:434-9. 2005..pathogenic agent of Alzheimer disease, in the brain through modulating proteolytic degradation catalyzed by neprilysin. Among various effector candidates, only somatostatin upregulated neprilysin activity in primary cortical ..
- Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signalingM Sumitomo
Urologic Oncology Research Laboratory, Department of Urology, and Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
J Clin Invest 106:1399-407. 2000....
- Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testisT Ouimet
Unité de Neurobiologie et Pharmacologie Moléculaire U109 de L INSERM, Centre Paul Broca, 2ter rue d Alesia, Paris, 75014, France
Biochem Biophys Res Commun 271:565-70. 2000..In brain, NEPII is expressed heterogeneously among several neuronal populations and according to a pattern grossly complementary to that of NEP...
- CD10 expression in stromal cells of oral cavity squamous cell carcinoma: a clinic and pathologic correlationA Piattelli
Dental School, University of Chieti Pescara, Chieti, Italy
Oral Dis 12:301-4. 2006..CD10 is expressed on the majority of follicle-center lymphomas and Burkitt lymphomas. CD10 has also been shown to be present in a variety of other neoplasms...
- Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neuronsEmi Hama
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
J Biol Chem 279:30259-64. 2004b>Neprilysin (NEP) is a rate-limiting amyloid beta peptide (Abeta)-degrading enzyme in the brain...
- A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injuryVictoria E Johnson
Penn Center for Brain Injury and Repair, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurotrauma 26:1197-202. 2009..association between amyloid deposition acutely after TBI and a genetic polymorphism of the AB-degrading enzyme, neprilysin (n = 81). We found that the length of the GT repeats in AB-accumulators was longer than in non-accumulators...
- Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator studyLuis Miguel Ruilope
Division of Hypertension, Hospital 12 de Octubre, Madrid, Spain
Lancet 375:1255-66. 2010LCZ696 is a first-in-class inhibitor of the angiotensin II receptor and neprilysin. We aimed to establish whether the dual actions of LCZ696 lead to further lowering of blood pressure, compared with the angiotensin-receptor blocker ..
- Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzymeJ Scott Miners
Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Bristol, UK
Brain Pathol 20:794-802. 2010..We measured BACE-1 activity and the levels and activities of neprilysin (NEP), insulin-degrading enzyme (IDE) and angiotensin-converting enzyme (ACE) in normal control brains (16 years-..
- Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysinYvonne S Eisele
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
Mol Biol Cell 18:3591-600. 2007..with the increase in AICD, Gleevec leads to elevated mRNA and protein levels of the Abeta-degrading enzyme neprilysin, a potential target gene of AICD-regulated transcription...
- Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidaseThomas Walther
Department of Cardiology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
PLoS ONE 4:e4590. 2009Neutral endopeptidase, also known as neprilysin and abbreviated NEP, is considered to be one of the key enzymes in initial human amyloid-beta (Abeta) degradation...
- B lymphopoiesis is active throughout human life, but there are developmental age-related changesMaria Isabel D Rossi
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Blood 101:576-84. 2003..Dramatic changes in human B lymphopoiesis occur early in life, and more information is required to construct a probable sequence of differentiation events prior to the acquisition of CD10...
- Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brainY Takaki
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Biochem 128:897-902. 2000..We analyzed the brain-derived enzyme by means of immuno-depletion and gene disruption, and demonstrate here that neprilysin accounts for the majority of the Abeta-degrading activity...
- Expression of neuropeptide-degrading enzymes in alopecia areata: an immunohistochemical studyM Toyoda
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
Br J Dermatol 144:46-54. 2001..However, there has been little substantial evidence of specific participation of cutaneous neurogenic factors in the disease process...
- Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxiaEdward C Dempsey
Cardiovascular Pulmonary Research Laboratory B 133, University of Colorado Denver, 12700 E 19 Ave, Aurora, CO 80046, USA
Am J Pathol 174:782-96. 2009b>Neprilysin is a transmembrane metalloendopeptidase that degrades neuropeptides that are important for both growth and contraction...
- Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levelsE Hellström-Lindahl
Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Geriatric lab, Novum, Floor 4, S 141 86 Stockholm, Sweden
Neurobiol Aging 29:210-21. 2008..b>Neprilysin has been shown to be an important enzyme to degrade A beta in brain...
- Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesisA Horiguchi
Urologic Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, NY 10021, USA
Prostate Cancer Prostatic Dis 11:79-87. 2008..05). Our data suggest that stable expression of NEP in DU145 cells inhibits prostate cancer tumorigenicity by inhibiting angiogenesis, with a probable mechanism being proteolytic inactivation of FGF-2...
- The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trialScott D Solomon
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet 380:1387-95. 2012..We assessed the efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), in patients with this disorder.
- Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1P Facchinetti
Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l INSERM, Centre Paul Broca, 2ter rue d Alesia, 75014 Paris, France
Neuroscience 118:627-39. 2003The localisation of the gene transcripts of a recently discovered peptidase, neprilysin 2 (NEP2), was established by in situ hybridisation in rat tissues during development and adulthood...
- CD10-positive stromal cells in gastric carcinoma: correlation with invasion and metastasisWen Bin Huang
Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital, 210002 Jiangsu Nanjing, People s Republic of China
Jpn J Clin Oncol 35:245-50. 2005..The aim of this study was to immunohistochemically investigate the rate of CD10 production in the stromal cells in our gastric carcinoma collection and clarify its correlation with invasion and metastasis...
- Tat peptides inhibit neprilysinAbigail Daily
Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40538 0509, USA
J Neurovirol 12:153-60. 2006..However, Tat protein and Tat-derived peptides were recently also shown to inhibit neprilysin, the major amyloid beta peptide degrading enzyme in brain, in a cell aggregate system...
- Enkephalinase inhibitors: potential agents for the management of painV Thanawala
Department of Pharmacology, Bharati Vidyapeeth s College of Pharmacy, Sector 8, CBD Belapur, Navi Mumbai, Maharashtra, India
Curr Drug Targets 9:887-94. 2008..EIs possess the advantage that they lack the opioid side effects. This article reviews the mechanisms by which EIs act and elucidates the pathways involved...
- The density of CD10 corresponds to commitment and progression in the human B lymphoid lineageMichiko Ichii
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
PLoS ONE 5:e12954. 2010..The CD10 ectoenzyme is one such marker and has been used to define CLP, but we found substantial tissue specific variations in CD10 levels, and there was no information about how that corresponded to differentiation options...
- Histologic and immunohistologic findings and prognosis of 40 cases of gastric large B-cell lymphomaM Takeshita
Department of Pathology, Clinical Laboratory, National Kyushu Medical Center Hospital, Fukuoka, Japan
Am J Surg Pathol 24:1641-9. 2000..Clinical staging and Bcl-6 expression were also good prognostic factors in patients with DLCL. Three groups of gastric DLCL each had unique histologic findings, immunohistologic characteristics, and prognosis...
- CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosisK Ohshima
First Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonan-ku, Fukuoka 814-01, Japan
Histopathology 39:156-62. 2001..Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL...
- Neprilysin and amyloid beta peptide degradationLouis B Hersh
Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY 40536, USA
Curr Alzheimer Res 5:225-31. 2008b>Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides...
- Neutral endopeptidase modulation of septic shockB Lu
Ina Sue Perlmutter Laboratory, Children s Hospital, Boston, Massachusetts, USA
J Exp Med 181:2271-5. 1995..This unexpected finding indicates an important protective role for NEP in septic shock...
- UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbitC P Wayman
Genitourinary Research Unit, Pfizer Global Research and Development, Sandwich, UK
Br J Pharmacol 160:51-9. 2010....
- Neprilysin protects neurons against Abeta peptide toxicitySalim S El-Amouri
Department of Molecular and Cellular Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA
Brain Res 1152:191-200. 2007..b>Neprilysin (NEP) appears to be the most potent Abeta peptide-degrading enzyme in the brain...
- Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysinKaiwei Liang
State Key Lab of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
J Biol Chem 285:935-42. 2010..we provide evidence that estrogen promotes Abeta degradation mainly through a principal Abeta degrading enzyme, neprilysin, in neuroblastoma SH-SY5Y cells...
- NEP-like endopeptidases and Alzheimer's disease [corrected]R A Marr
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
Curr Alzheimer Res 7:223-9. 2010..Of particular interest are endopeptidases that are sensitive to the neprilysin inhibitors thiorphan and phosphoramidon (i.e...
- Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytesLilia Fisk
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Mount Preston Street, Leeds, LS2 9JT, UK
Neurochem Res 32:1741-8. 2007..brain has an endogenous mechanism of Abeta removal via proteolytic degradation and the zinc metalloproteinase neprilysin (NEP) is a critical regulator of Abeta concentration. Down-regulation of NEP could predispose to AD...
- CD10 expression in stromal cells of ameloblastoma variantsGiovanna Iezzi
Research Fellow, Dental School, University of Chieti Pescara, Chieti Pescara, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:206-9. 2008....
- Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility statesHeiko Meyer
Department of Zoology Developmental Biology, University of Osnabruck, Germany
J Exp Biol 212:3673-83. 2009..Here we report on the identification and first characterization of neprilysin 4 (NEP4) from Drosophila melanogaster...
- Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic miceBrian Spencer
Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
BMC Neurosci 9:109. 2008..The endopeptidase, neprilysin, has been implicated as a major Abeta degrading enzyme in mice and humans...
- Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's diseaseJohn B Rose
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurosci 29:1115-25. 2009The endopeptidase neprilysin (NEP) is a major amyloid-beta (Abeta) degrading enzyme and has been implicated in the pathogenesis of Alzheimer's disease...
- Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndromeJane A Byrne
Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
Lab Invest 87:1138-48. 2007..Liver CD10 in childhood appears to undergo reduced synthesis or rapid degradation, which persists in AGS. Absence of CD10 expression thus may limit NEA as a marker of cholestasis in young patients and in AGS...
- Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptideE Hama
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Med Hypotheses 65:498-500. 2005We recently demonstrated that amyloid beta peptide (Abeta) is catabolized primarily by a neutral endopeptidase, neprilysin, in the brain and that a neuropeptide, somatostatin (SST), regulates brain Abeta level via modulation of neprilysin ..
- Accumulation of insoluble amyloid-β in down's syndrome is associated with increased BACE-1 and neprilysin activitiesJames Scott Miners
Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Bristol, UK
J Alzheimers Dis 23:101-8. 2011..disease (AD)-related increases in the activities of β-secretase (BACE-1) and Aβ-degrading enzymes including neprilysin (NEP) and angiotensin-converting enzyme (ACE) in the frontal cortex...
- Comparison of multiparameter flow cytometry with cluster analysis and immunohistochemistry for the detection of CD10 in diffuse large B-Cell lymphomasYin Xu
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
Mod Pathol 15:413-9. 2002..Our results indicate 75% sensitivity and 100% specificity of CD10 expression by IHC compared with multiparameter FC with cluster analysis and a 6% technical failure rate...
- Clearance of Alzheimer's Abeta peptide: the many roads to perditionR E Tanzi
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
Neuron 43:605-8. 2004..This minireview will summarize pathways involved in the removal of cerebral Abeta, including enzymatic degradation and receptor-mediated efflux out of the brain...
- Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer diseaseMatthew L Hemming
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Neurobiol Dis 26:273-81. 2007..Furthermore, we find no change in plaque deposition or in peripheral Abeta levels. Data from these Alzheimer models suggest that captopril and similar ACE inhibitors do not cause Abeta accumulation in vivo...
- Mechanisms of toxic smoke inhalation and burn injury: role of neutral endopeptidase and vascular leakage in miceSam Jacob
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA
Toxicol Mech Methods 19:191-6. 2009..026) as compared to mice with SB injury alone. In conclusion the current study indicates that specific NEP inhibitor CGS 24592 exacerbates the SB-induced lung injury and inflammation in mice...
- Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cellsF Kikkawa
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
Placenta 25:176-83. 2004..In conclusion, GnRH induces NEP expression by PKC delta and p38MAPK, and increased NEP expression may be involved in antiproliferative effect in BeWo cells...
- Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic ratsV Arbin
Laboratoire de Pharmacologie, U266 INSERM, UMR 8600 CNRS, U F R des Sciences Pharmaceutiques et Biologiques, Paris, France
Br J Pharmacol 130:1297-304. 2000..These effects are linked to an increased activation of the kinin-NO pathway. BK could lead to NO production by BK B2 receptor activation and another pathway in which kininase I may be involved...
- Substance P and neutral endopeptidase in development of acute respiratory distress syndrome following fire smoke inhalationSimon S Wong
Department of Pediatrics Critical Care Medicine, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
Am J Physiol Lung Cell Mol Physiol 287:L859-66. 2004....
- Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficitRaphael Poirier
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, Zurich 8008, Switzerland
Neurobiol Dis 24:475-83. 2006..Lowering brain Abeta levels, therefore, is a therapeutic strategy for the treatment of AD. Neuronal neprilysin upregulation led to increased degradation of Abeta, reduced the formation of Abeta-plaques and the associated ..
- Treatment of streptozotocin-induced diabetic rats with AVE7688, a vasopeptidase inhibitor: effect on vascular and neural diseaseEric P Davidson
Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA 52246, USA
Diabetes 56:355-62. 2007..These studies suggest that vasopeptidase inhibitors may be an effective approach for the treatment of diabetic vascular and neural dysfunction...
- Roles of neutral endopeptidase in airwaysD B Borson
Department of Physiology, University of California, San Francisco 94143 0911
Am J Physiol 260:L212-25. 1991....
- Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEPDamiano Rizzoni
Department of Medical and Surgical Sciences, University of Brescia, DMCS Clinica Medica 4, University of Padua, Italy
J Hypertens 22:759-66. 2004....
- Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studiesRandal A Skidgel
Department of Pharmacology, University of Illinois College of Medicine, Pharmacology MC 868, 835 S Wolcott Avenue, Chicago, IL 60612 7344, USA
Peptides 25:521-5. 2004..extended to the hydrolysis of the neuropeptide, neurotensin and to compare hydrolysis of the same peptides by neprilysin (neutral endopeptidase 24.11, CD10, NEP)...
- Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathwaysEva Sanz
Departamento de Medicina, Universidad de Alcala, Alcalá de Henares 28805, Spain
Proc Natl Acad Sci U S A 107:5925-30. 2010..Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway...
- CD10 expression in diffuse large B-cell lymphomas does not influence survivalBettina Fabiani
Departement de Pathologie, Hopital Saint Antoine, AP HP, Paris, France
Virchows Arch 445:545-51. 2004..44 and P=0.34 respectively). Therefore, it appears that CD10 expression does not influence survival or event-free survival in DLBCL...
- Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green teaShereen Ayoub
Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Str 2 4, 14195 Berlin, Germany
J Pharm Pharmacol 58:495-501. 2006..It is suggested that the enhancement of cellular neutral endopeptidase activity by green tea extract and its natural products might be correlated with an elevated level of intracellular cyclic adenosine monophosphate...
- Hyposialylation of neprilysin possibly affects its expression and enzymatic activity in hereditary inclusion-body myopathy muscleAldobrando Broccolini
Department of Neuroscience, Catholic University, School of Medicine, Rome, Italy
J Neurochem 105:971-81. 2008..h-IBM muscle shows the abnormal accumulation of proteins including amyloid-beta (Abeta). Neprilysin (NEP), a metallopeptidase that cleaves Abeta, is characterized by the presence of several N-glycosylation sites, ..
- Involvement of neutral endopeptidase in neoplastic progressionMakoto Sumitomo
Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
Biochim Biophys Acta 1751:52-9. 2005..We review the mechanisms of NEP's tumor suppressive action and how NEP loss contributes to tumor progression...
Research Grants76
- NEURAL REGULATION OF PANCREATIC FUNCTIONKIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010....
- NEURAL REGULATION OF PANCREATIC FUNCTIONKIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010....
- NEUROPEPTIDE DEGRADATION IN THE SMALL INTESTINENigel Bunnett; Fiscal Year: 1993..Knowledge of interaction between NEP, SPR and SP will provide basic information about the nature of peptidergic neurotransmission in the normal and inflamed intestine...
- NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATIONEileen Grady; Fiscal Year: 2006..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
- Prevention of Diabetic Neuropathy with ACE InhibitorsMARK ANTHONY YOREK; Fiscal Year: 2010..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
- Prevention of Diabetic Neuropathy with ACE InhibitorsMark Yorek; Fiscal Year: 2009..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
- INTRARENAL REGULATION OF SODIUM EXCRETIONJohn Burnett; Fiscal Year: 2004..Aim 4: Establish that dietary sodium excess accelerates the development of cardiac remodeling and overt CHF in part via up-regulation of NEP. ..
- NEURAL REGULATION OF PANCREATIC FUNCTIONKimberly Kirkwood; Fiscal Year: 2002..Using neurokinin receptor antagonists, peptidase inhibitors, and knockout mice, we will delineate the neurogenic mechanisms that regulate inflammation in acute pancreatitis. ..
- NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATIONEileen Grady; Fiscal Year: 1999....
- INTRARENAL REGULATION OF SODIUM EXCRETIONJohn Burnett; Fiscal Year: 2000....
- TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPEMarcia N Gordon; Fiscal Year: 2010..b>Neprilysin is a major amyloid degrading protease, and a prime candidate for use in anti-amyloid gene therapy...
- Untangling Amyloid Plaques With ProteasesJin Moo Lee; Fiscal Year: 2010..of some of these proteases in vivo have resulted in increased steady-state levels of brain A? in mice, including neprilysin (NEP), insulin-degrading enzyme (IDE), endothelin-converting enzyme (ECE)...
- Untangling Amyloid Plaques With ProteasesJin Moo Lee; Fiscal Year: 2009..of some of these proteases in vivo have resulted in increased steady-state levels of brain A? in mice, including neprilysin (NEP), insulin-degrading enzyme (IDE), endothelin-converting enzyme (ECE)...
- Prevention of Diabetic Neuropathy with ACE InhibitorsMark Yorek; Fiscal Year: 2007..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of ACE inhibitor treatment in human DN. ..
- A screen for small molecule inhibitors of soluble Abeta oligomer assemblyHarry LeVine; Fiscal Year: 2007..with compound, will be screened with trypsin, and if positive, digested with insulin-degrading enzyme and neprilysin, proteases believed to degrade Abeta peptides in vivo...
- DIABETIC NEUROPATHY: IMPLICATIONS FOR WOUND REPAIRNicole Gibran; Fiscal Year: 2002..Using an excisional would model in hyperglycemia db/db mice, we will replace substance P, replace NGF or inhibit neutral endopeptidase activity to evaluate the roles of neuropeptides and NGF in wound repair. ..
- The Role of Cathepsin B and Cystatin C in Alzheimer's DiseaseLi Gan; Fiscal Year: 2010..However, unlike some other Abeta degradation enzymes, such as neprilysin (NEP, an endopeptidase with optimal activity at a neutral pH), CatB truncates Abeta at the C-terminus with ..
- GENES AND FIBRINOLYTIC CAPACITY OF HUMAN ENDOTHELIUMNancy Brown; Fiscal Year: 2006..It is expected that these pharmacogenetic studies will yield critical new information and strategies for enhancing the favorable effect of the kallikrein-kinin system on fibrinolysis and the risk of thrombotic cardiovascular events. ..
- LXR and PPARgamma mediated Abeta clearance mechanismsGary Landreth; Fiscal Year: 2007..that lipidated forms of ApoE facilitate the intracellular degradation of A¿ peptides by microglia through neprilysin- dependent proteolysis...
- LXR and PPARgamma mediated Abeta clearance mechanismsGary Landreth; Fiscal Year: 2009..We show that lipidated forms of ApoE facilitate the intracellular degradation of A peptides by microglia through neprilysin- dependent proteolysis...
- LXR and PPARgamma mediated Abeta clearance mechanismsGary Landreth; Fiscal Year: 2009..We show that lipidated forms of ApoE facilitate the intracellular degradation of A peptides by microglia through neprilysin- dependent proteolysis...


text:
"TOLEDO, Ohio –- It's too soon to tell if the water is safe in Toledo, Gov. John Kasich said Sunday.
The toxin microcystin, found in Lake Erie, polluted the water supply early Saturday morning. Residents have been without running water for more than 24 hours." (source)
Would you be ready if your water suddenly got shut off or was unsafe to drink? We should all have some water storage on hand, and a way to filter any available water. The WaterBrick is an easy to use, portable water storage option.
How much water do you need for emergencies?
- 1/2 Gallon (2 Liters) per day, per person for drinking and cooking
- 1/2 Gallon (2 Liters) per day per person for hygiene (washing, teeth cleaning, dishes, etc)
Minimum water storage = 1 gallon per person per day = 14 gallons per person for 2 weeks = 56 gallons per a family of four for 2 weeks
Under "normal" conditions, the average person in the US uses over 16 gallons per day, so you could blow through two weeks of water storage in a day if you are careless. [Read more...]

subset: commoncrawl


text:
small, yet there are a few options . . .
Last response: in Components
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text:
Soldiers of color, be it white, black, red, brown or yellow, have one human characteristic in common: we all bleed the same color. The warrior covering your back most likely wears the same color uniform, yet his or her race, creed or color has no relevance on the value of training or their desire to simply do what is right.
Their aphorism, 'Dedicated Unhesitating Service To Our Fighting Forces' was better known in Vietnam by its acronym 'Dustoff'. These were the medevac choppers. Unarmed and unwavering, the courageous crews of 'Dustoff' missions flew their Hueys into combat zones to bring out the wounded, the dying, and young soldiers covered with rain ponchos. 'Dustoffs' were clearly marked with the Red Cross insignia to signify a mercy flight, yet that distinctive Red Cross also became a prime target for Communist gunners.
Personality Plus best describes her spunk and spirit, and I knew a story of love and sacrifice resided in her heart. Little did this journalist know that her home front narrative would open the door to one of the most remarkable untold accounts of World War II. If made into a movie, I'll volunteer to write the screenplay.
A heart attack took the life of George H. Gay Jr. at a Marietta hospital on October 21, 1994. A resident of Kennesaw, Gay was a well-known hero of WWII. Now, as history books are rewritten and military icons are shunned by reformists, let us hope that Gay's story will remain an embodiment of the courage and sacrifice of a generation that saved a world from totalitarianism.
He sported a big elongated nose, a smooth bald head, beady eyes, and three to four fingers of each hand dangled over the imaginary line of an imaginary wall. A rather comical figure, yet pitifully ugly if symbolic of a real person, Kilroy quickly developed into one of the historic symbols of World War II.
Far from his wife and newborn, John Butler kept finding himself in the battlefield with one set of instructions: "Find the bastards, and pile on."
The cavalry still mount their steeds, but these horses are of a motorized breed. In Vietnam the mounts were named Loach, Huey, Cobra, Osage, Chinook, Mohawk and the superseded Raven (achieved recognition in three early James Bond films). These hi-tech mounts could saddle up more than just one soldier and the cavalrymen gripping the reins were some of the bravest of the brave in Southeast Asia.
Seventeen-year-old Macon native Ron Holmes received the displeasing news upon high school graduation in June of 1963 - his appointment to the Air Force Academy had been denied because of a new prerequisite that required uncorrected 20/20 vision.
Page 1 of 1
History refers to a particular confederation of GIs as veterans of "The Forgotten War," a war that tested the very best America could field, both experienced and untried.
After their youngest son, Hugh, had completed a few days in the first grade, Johnny and Ada Steele playfully asked if he'd found a girlfriend yet. The 6-year-old responded, "Yes, I have found the girl I'm going to marry. Her name is Dorothy Lassiter. Even if I wander the whole world over, I'll never find another one like her." In 1947, WWII veteran Hugh Steele married Dorothy Lassiter, and they remained as husband and wife for 65 years until her passing.
I love those commercials on television that have a man impersonating an appliance. The dishwasher licks the whip, and the refrigerator complains that he must work every minute of every day while the blender sits in a cabinet and does nothing for most days of the month.
Japanese soldiers wore gas masks to suppress the nauseating smell of sulfur as they dug deep into the bowels of Iwo Jima. Eventually, an 11-mile maze of tunnels would connect underground barracks, hospitals, ammo dumps, water supplies and foodstuffs. Above the tunnels, bunkers and pillboxes by the hundreds awaited the American assault that was inevitable.
At approximately 0600 on the morning of June 6, 1944, the warships of Task Force 125 began their bombardment on German positions behind Utah Beach. Overhead, 276 Marauder B-26 medium bombers dropped tons of bombs on selected targets from les Dunes de Varreville to Beau Guillot.
On May 19, 1802, Napoleon Bonaparte established the 'Ordre National de la Legion d'honneur' (National Order of the Legion of Honor), better known as the Legion of Honor. Presented for extraordinary civilian and military contributions to the fatherland, the Legion of Honor is France's highest distinction.
More than one Leatherneck would agree, it's befitting that a young man from Montezuma chose to join the United States Marine Corps. The month was November, the year 1965, the man: Eli Fobbs.
A 1948 "Grady baby", Steve Blanton recalled a childhood without modern conveniences. "We were very poor. We had no indoor plumbing and I toted water from Granny's house because she had city water. Heat was generated by a wood burning stove, I remember the old lamp lights and thought we were rich when we finally got electricity."
Many Vietnam veterans have visited Our Wall to pay tribute to the
An airfield in northeast Thailand designated as NKP (Nakhon Phanom) during the Vietnam War was actually a Royal Thai Naval Base. The Thais utilized NKP as a home base for river patrols along the murky Mekong River, the internationally accepted border between Thailand and Laos. The small community of Nakhon Phanom on the banks of the Mekong became a boom town during the American involvement in Southeast Asia.
After absurd bickering and declining political roadblocks, "men of color" were finally able to serve in the United States Marine Corps. The date was June 1, 1942. Sent to Camp Lejeune, N.C., for training, black recruits quickly discovered a segregated military still existed; they were assigned to a separate training facility called Montford Point.
It's not yet 10 a.m. on Wednesday Feb. 12, and the Peach State's 2014 Icemageddon already has Georgians in its Arctic grip.
Fortunately, Black History Month basically assures us that young Americans will be taught about the immortals of African-American achievement. The contributions by Americans with the names Frederick Douglass, W.E. B. Du Bois, Booker T. Washington, George Washington Carver and Martin Luther King Jr. should be known to all teachers and students of American history.
Call it divine intervention, luck or just a turn of events – Charles Wyatt had his life saved.
ive branches of the military are officially recognized: Army, Air Force, Coast Guard, Navy, and Marines. This journalist, though, believes that two other factions should be commended: the Merchant Marines and the Home Front.


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Italian Honey Fig Tree
2 crops each year!
Incredibly sweet figs taste great right off the tree, dried, or preserved.
Nothing compares to the rich, sweet flavor of fresh tree ripened figs! With this slow-growing, very heavy-bearing variety you get not one but TWO crops of yummy figs every year -- from a tree that reaches a generous but very manageable 15 feet high!
The delicious, honey fleshed fruit of this hybrid does not need hot summer weather to ripen, so plants produce two generous crops each year, even in the North! You don't need another Fig for pollination, either (though your yields will improve with other Figs nearby.) This fruit is excellent fresh, dried, or preserved! Zones 7-10.
|'Italian Honey'
|Item Form
|Trade Gallon (3qt)
|7 - 10
|Plant Height
|12 ft - 15 ft
|Plant Width
|12 ft - 15 ft
|Additional Characteristics
|Foliage Color
|Dark Green, Medium Green
|Light Requirements
|Full Sun
|Moisture Requirements
|Moist, well-drained
|Soil Tolerance
|Normal, loamy
|Guam, Virgin Islands, Arizona, Canada, Hawaii, Puerto Rico
Overall Rating: 5 StarsAverage Based on 4 Reviews Write a Review
Love my Fig tree
I have had my tree over 10 yrs and I now call it Frankenfig. It is huge. I have to cut it back every Feb. I had always heard you are supposed to plant it against a wall (which I did). As stated before, the spring crop isn't so much but I, too, have to harvest morning and evening with the 2nd one. The only drawback is the bees.
delicious and a no-brainer
we planted our fig tree this past April and are getting lots of delicious figs. The tree (really a bush at this point) is in a large container on our terrace, about 4 stories up.
Great fig tree
I've had one of these for 4 years and it is doing great. The figs are extremely sweet and make great perserves. Plant is hardy and takes heat and cold well.


text:
2/F SM City Dasmarinas Governors Drive , Dasmarinas, Cavite, +63(46)4323201
Showtimes for Today, 01 Sep
Pudsey The Dog
Cinema 1: 01:15 PM 03:35 PM 05:55 PM 08:15 PM
Stray dog, Pudsey, who is quite happy being a lone ranger, looking out for number one, until he meets siblings Molly, George and Tommy. After losing their father, their mother Gail is moving the family to the sleepy village of Chuffington and Pudsey tags along, to the dismay of their landlord, Mr...
Rurouni Kenshin: Kyoto Inferno
Action, Drama
Cinema 2: 11:45 AM 02:35 PM 05:25 PM 08:15 PM
Kenshin Himura goes up against pure evil Makoto Shishio who is attempting to overthrow the Meiji government. The fate of the country hangs in the balance as Kenshin Himura takes up the sword that he vowed to never draw again. (From IMDb)
Teenage Mutant Ninja Turtles
Action, Adventure, Comedy
Cinema 3: 12:30 PM 03:10 PM 05:50 PM 08:30 PM
Darkness has settled over New York City as The Shredder and his evil Foot Clan have an iron grip on everything from the police to the politicians. The future is grim until four unlikely outcast brothers rise from the sewers and discover their destiny as Teenage Mutant Ninja Turtles. The Turtles m...
Talk Back And You're Dead
Romance, Comedy
Cinema 4: 10:30 AM 01:00 PM 03:30 PM 06:00 PM 08:30 PM
It is a story of a girl named Samantha, a beautiful girl, talented and lives in a wealthy family is about to change her life after the incident happen in mall when she see her friend betrayed by his boyfriend. As her friend, he defend it to a guy, but she never knew that the guy he fought was a v...
Cinema 5: 12:00 PM 02:00 PM
Provoked follows a group of amateur investigators who, despite investigating for months, have never found any proof of the paranormal. During the group's most recent investigation, like many times before, they come up empty. At this point, team member Matt losing faith in the existence of the par...
Sin City: A Dame To Kill For
Action, Crime, Thriller
Cinema 6: 12:45 PM 03:20 PM 05:55 PM 08:30 PM
The town's most hard-boiled citizens cross paths with some of its more reviled inhabitants. (From IMDb)


text:
Knockers: $10.00. You can remove a wheel from the axle with the use of a hub puller if you have a Knocker. Its a good item to carry in under your seat. Some of the knockers with the white paint are for car with larger axles. The rest are T size. Please include $6.00 postage.
Dave Huson
2116 Charro Ave. Longmont, Co. 80504
Email: firstname.lastname@example.com
Phone: 303-774-9246
I thought knockers came in pairs?
Hey Ron: I saw a great pair of white knockers at my son's store today and she wanted something faxed out, HUM HUM>
Bill D
I knew it couldn't be for real! This isn't Craigslist.
Soooo not what I thought it would be!!


text:
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Exposure Best Photography5 Reviews
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Exposure Best Photography specializes in wedding and event photography. Our goal is to capture the essence of a bride and grooms wedding day so...(more)
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Ful Time: Professional Wedding Photography & HD Videography
St. Tammany, New Orleans, Baton Rouge, Serving All Of Southeast Louisiana, LA | 985-276-4856
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Greer G Photography29 Reviews
Gretna, LA | 504-931-0622
Hi, I'm Greer, and I have an incredible passion for weddings. My documentary style combines the look of vintage nostalgia with modern elegance. I...(more)
matthew foster photography26 Reviews
New Orleans, LA | 504-237-9845
Matthew Foster is a New Orleans based photojournalist. He employs a friendly and patient approach to seeking out the spirit and uniqueness of each...(more)
Stacy Marks Photography12 Reviews
Voted Photographer of the Year! Wedding Professionals Guild of New Orleans.
Metairie, LA | 504-237-2173
Stacy Marks' love of photography, fashion, and family is the gift he brings to your wedding day. In order to capture all of the love, time, care...(more)
Eye Wander Photo60 Reviews
Raw Beauty Defined
Baton Rouge, LA | 225-366-4567
Raw Beauty Defined. That sums up our photography. We believe the wedding day to be an extremely beautiful event that deserves to be captured with...(more)
Studio Tran Photography79 Reviews
Metairie, LA | 504-258-7260
Shantelle's review: Eric and his crew were so wonderful to work with! I would defiantly recommend them!!! I look forward to working with... (more)
George Street Photo & Video803 Reviews
Your Moments. Forever.
George Street offers unparalleled photojournalistic photographic talent and creativity, personalized customer service, and prices for any wedding...(more)
Thompson Photography4 Reviews
Photojournalism with an Artistic Touch
Baton Rouge, LA | 225-590-1683
Welcome! We at Thompson Photography know that it can seem like there is an endless list of wedding photographers to sift through when planning your...(more)
Lauren Carroll Photography8 Reviews
Hammond, LA | 985-277-9782
Hello! I'm Lauren. My work is inspired by life and love. Capturing important moments in time and raw emotion fuels my love for this business! Each...(more)
Callie Hill Photography4 Reviews
Denham Springs, LA | 225-636-9632
First of all, thank you for taking the time to learn a little bit about me! I am a wife to my best friend (and videographer),Daniel...(more)
Christie Froom Photography
New Orleans, LA | 318-470-4632
Photography By Christy4 Reviews
Covington, LA | 985-892-4055
Photography is my passion. It started as a hobby in high school, but was put aside as i pursued other intrerest. After getting married and having a...(more)
Heirloom Collective27 Reviews
New Orleans, LA | 225-205-8883
Heirloom Collective is a nation-wide network of photojournalists and designers focused on creating unique and timeless images that reflect your...(more)
Bray Danielle Photography73 Reviews
Voted Bride's Choice Award 2012 & The Knot Best of Weddings Award 2012
Baton Rouge, LA | 225-753-3601
Cierra Johnson Photography3 Reviews
Denham Springs, LA | 225-439-0566
Photography has been a part of my life for many years! A few years ago I decided to make this passion for photography and all things weddings, a...(more)


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...Moreover, I relate to many younger students. It is easy for me to get along with people and help them with any problems they have, in education and even personally if necessary. A little about me, I grew up in New York with great family and friends.
29 Subjects: including phonics, special needs, English, chemistry
New York, NY
...I'm a classroom History teacher, and 99% of my students successfully passed their NYS History Regents exams with high marks. I enjoy teaching and waking up every single morning to go to work. Not only do I teach History, but I also teach test taking skills, to give my students a boost of confidence and energy.
36 Subjects: including phonics, English, ADD/ADHD, dyslexia
Brooklyn, NY
...In addition, I also teach Living Environment, Regents level. I look forward to meeting you and helping you on your quest to academic success! Gigi I have a master's degree in Special Education, and I am a NYS Certified Special Education Teacher with more than 15 years of experience.
12 Subjects: including autism, phonics, Aspergers, special needs
Baldwin, NY
...I hope to work with you! Did you know that two of the quickest and easiest ways to boost your SAT writing score are to learn to eliminate wordiness and to minimize passive sentence constructions? Did you know that there are simple rules governing the placement of commas and semicolons?
18 Subjects: including phonics, English, reading, writing
Brooklyn, NY
...During my senior year, The York Scholar, the school's academic journal, published my research paper on the reading habits of internet users in relation to their exposure to digital technologies and media, a six-week process that taught me the drafting and editing procedures necessary to produce a...
28 Subjects: including phonics, English, reading, writing
New Hyde Park, NY


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This week, we explore customers who refuse to try to understand how to words, and then get extremely angry about it. Once again, for future editions, for anyone who said they had "so many stories" but who has yet to e-mail me...there's no time limit on being able to do so. email@example.com.
Kitchenette: New Behind Closed Ovens
Pending approval C.A. Pinkham
Filed to: Kitchenette 3/31/14 11:14am 3/31/14 11:14am


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6 Best Fixes for Hair Loss
Whether you've only recently noticed a thinning hairline or have made a baseball hat to hide your bald spot a wardrobe staple, you've probably tried at least one hair loss product or home remedy.
"The truth of the matter is that baldness comes down to your genes," says Frederick Joyce, M.D., founder of Rejuvenate! Med Spa and a member of the International Society for Hair Restoration Surgery. "If you have the baldness gene, there are some natural remedies that may make your hair stronger and healthier to slow your hair loss slightly —but they won't prevent you from going bald. Still, maintaining hair health by eating well and using the right products—combined with medical-grade treatments—can really work all together to help you have a fuller, thicker head of hair."
While using stem cells to regrow hair is promising, it's still years away from becoming available as a hair loss treatment. So here is the low-down on which baldness solutions available now are truly effective—and which hair-loss fighters are merely snake oil.
more galleries
- Seasonally AppropriateFind a signature scent that's spot-on for summer.
- 10 Best Sources of FiberFiber-filled foods that aid weight loss.
- Perfect 10The hottest NFL cheerleaders of 2014.
- Update Your Hair Products for SummerStock these seven grooming products.


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3 month ago
Girls' Generations appear on Chinese variety show, "Strongest Group"
", girls generation have been focusing on individual activities, but came together for a chinese variety show titled, "strongest group". "they continued on to list.
3 month ago
Girls' Generation and Super Junior to Appear on Chinese Variety Show.
The airing dates for super junior and girls' generation's episodes have yet to be announced. Although the group has appeared on chinese tv shows individually or in smaller.
3 month ago
EXO-K discloses the member who has the strongest 1st impression
Was chosen by the majority of his fellow members as the one who seemed difficult to mingle with. Didn't have a very good eyesight then which caused a misunderstanding. "written.
3 month ago
EXO-K reveals which member had the strongest first impression when they.
On the most recent episode of mnet's "xoxo exo" kai shared his thoughts about the first time he met d. With the end of their show, many fans took to messaging boards.
2 Year ago
K-Music To Have Strongest Showing in SXSW 2013 in Austin: f(x) Leads.
What makes it even more exciting is that a hallyu favorite, sm entertainment's f(x) gets to have a stage. This makes the victory of having ten korean music acts showcasing.
2 Year ago
Jewelry Ye Won & U-KISS Hoon, Chosen As the Strongest Wrestling Idols.
In her last round with after school's ga eun, she showed superior wrestling skills despite her short height, and became the final winner. Hoon, who played his final round.
2 Year ago
Kim Heung Guk's son to perform on Strongest Victor Quiz Show Q'
" in addition, he continued to passionately perform, the beatles' hit song, 'hey jude', leading to a round of applause. Kim heung guk talked about his son and.
2 Year ago
SM Entertainment has the Strongest Line-Up in Music, Acting and Entertainment.
"sm c&c ceo kim young min commented, "with world stars such as jang dong gun and kim ha neul merging with us, we will be able to spread out into asia and internationally.
2 Year ago
T-ara is chosen as the "girl group with the strongest determination".
1 asia – girls' generation, and kara in third with 369 votes (2. Followed in second with 860 votes (5. 8%) is girl group no. Recently, however, rumors of discord within.
2 Year ago
Go Eun Ah comments on her portrayal of the "tomboy" in 'Strongest.
" she humorously added, "since i've lived for more than two months as seung yeon, it's gotten to the point that sometimes, i feel like i'm confused about my gender.
2 Year ago
Actor Park Yoohwan talks about his new role in 'Strongest K-Pop.
" when asked about his singing and dancing talent, he remarked, "my brother is really talented, so i was sure that i possessed some of those genes as well. With his.
2 Year ago
MBLAQ's G.O. and Mir release "I Already Knew" for 'Strongest.
With their ost song, "i already knew", it tells of a heartbreaking break up, in which the singer acknowledges the lover's indifference. And mir once again showed their.
3 Year ago
MBLAQ to Appear on Upcoming Drama, "The Strongest K-Pop Survival"
Mblaq has been spotted on set for the upcoming drama, "the strongest k pop survival. "mblaq will be making a special appearance in the drama, according to sources on march.
3 Year ago
MBLAQ makes a cameo appearance in The Strongest K-POP Survival
Go eun ah plays ji seung yeon, a cheerful girl who dreams about becoming a legendry hip pop rapper. Go delivered her feelings about working with mblaq's members: "i.
3 Year ago
New still cuts of MBLAQ and Go Eun Ah on the set of 'Strongest.
I feel like i had a great team of support with mir and his mblaq members on the set with me. New still cuts of members lee joon, thunder, g. Go eun ah expressed, "it feels.
3 Year ago
MBLAQ to make a cameo appearance on 'Strongest K-POP Survival'
"he gives me a lot of advice, but i think it also leaves him at a loss for words. " "i first call my brother to let him hear the rap before i perform it on set,".
3 Year ago
ENG SUB INFINITE - L's Strongest Rival is Yoseob?!
Eng sub infinite l's strongest rival is yoseob?! * just a short clip. )* as it's written in the subs, a "sunsaengnim (선생님)" means a teacher or a (really) big sunbae.
3 Year ago
*RE-UP* ENG SUB INFINITE - L's Strongest Rival is Yoseob?!
)* as it's written in the subs, a "sunsaengnim (선생님)" means a teacher, or a (really) big and old sunbae. *re up* eng sub infinite l's strongest rival is yoseob?! *.
3 Year ago
New Drama "The Strongest K-Pop Survival" Releases Teaser Poster
A new channel a drama, "the strongest k pop survival," has announced its strong cast and has revealed a teaser poster. In the revealed teaser poster, you can catch a glimpse.


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A collection of news and information related to UC Davis published by this site and its partners.
Top UC Davis Articles
Displaying items 89-99
Skelton: Jerry Brown should have signed more gun bills
Brutal responses to Occupy protesters signify deep disconnectColumn | Sep 27, 2013 | 12:30 PMLast weekend, while listening to an NPR story about police using tear gas and rubber bullets to break up a demonstration, I was actually surprised when it turned out the newscaster was talking about Tahrir Square -- I had assumed it was about another...
Their love became a textbook movie romance
Severe drought? California has been here before
Readers offer New Year's resolutions on pet careColumn | Sep 30, 2013 | 6:30 AMHere are some 2013 New Year's resolutions from near and far, posted by fans on my Facebook page: "My resolution is for my heart and mind to follow the Serenity Prayer in my pet rescue efforts: 'God grant me the serenity to accept the things I cannot...
The International Space Station, through the astronauts' eyes
Cool magma, Mt. Hood and the future of volcano eruption prediction
Briefs: Newland adds another honorStory | Feb 15, 2014 | 11:20 PMLegendary UC Irvine coach Ted Newland will be inducted into the USA Water Polo Hall of Fame April 5 at the Hotel Irvine Jamboree Center in Irvine. Newland, in his 39 years as UCI's men's water polo coach (1966-2004), amassed 714 victories and led the...
Outrageous payout for the 'pepper-spray cop': Fury we can agree on
Occidental Petroleum to sell stakes in Middle East, North Africa
British journal again ranks Caltech best university in world


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MADISON (WKOW) -- A Madison man caused a disturbance after he had to leave the mall for not following a pants policy.
According to the Madison Police Department, officers were called to a disturbance at East Towne Mall around 9 p.m. Friday. Police say Steven L. Price was warned by mall security that he needed to pull his pants up. The mall policy is to not expose underwear to other patrons.
Price refused, and he was removed from the mall, but he returned. Mall security stopped Price, but Price was resisting and created a disturbance.
Price was then arrested and taken to Dane County Jail.


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Winners of the Healthy Lunchtime Challenge recently visited the White House for the third annual Kids' State Dinner.
Richard Sherman goes into the White House Kitchen to cook up something special.
The First Lady heard from school leaders about the work they are doing to improve school nutrition in their local districts.
If you wanna stay active and healthy, you've gotta Drink UP. Just ask Sunny and Bo.
People of all ages demostrated how they move & now it's the President & Vice President's turn.
President Barack Obama has proclaimed September 2014 as National Childhood Obesity Awareness Month, encouraging Americans to help our youth lead more physically active lifestyles and make healthier food choices.
Continue reading story


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I just got this in an email.pig race mosque pt 2 - YouTube
Patron Member NRA
"I would not be an old man if I had not been an armed young man." JTJ
"Political correctness is a doctrine, fostered by a delusional, illogical minority, and promoted by mainstream media, which holds forth the proposition that it is entirely possible to pick up a piece of feces by the clean end."
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Are you a firearms enthusiast? Then we hope you will join the community. You will gain access to post, create threads, private message, upload images, join groups and more.
Firearms Talk is owned and operated by fellow firearms enthusiasts. We strive to offer a non-commercial community to learn and share information.
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First, the mullah is an idiot for not investigating what they were buying. Second, he needs to learn the meaning of "good neighbor". Third, piss off one of those Texas boys by calling him a liar in front of his neighbors, you had better get used to the smell of BBQ blowing your way.
We have been through this with Muslim grocery store cashiers that "cannot handle bacon or ham". Hint- you applied for the wrong job. Hey- I think I will go buy a house at the end of the runway, and complain to the airport about the noise.
Idiots. Surrounded by idiots. How the hell did I let THAT happen?
<--- Your Moderators at our weekly Troll Hunt
I'd wait till that SOB goes out of town for a weekend and turn about 5 of those porcine wonders loose in the bastards living room.
If y'all haven't noticed, this has pissed me off.
Dead Bears, the only good kind.
This is only a couple of miles down the road from my home 20 and we love this guy. Typical Texan response to someone messin with us.
I see that all the time out where I live. Not particularly the hog farms but the 'city folks' move out to the 'country' and then bitch that we have no malls and the town just about closes down at 2000 on weekdays. Yeah, that's the way it is. The air smells like 'porcine feces' in the spring when the farmers fertilize and they roads are dusty. Yeah, that's right, THIS IS THE COUNTRY LIFE. They move here for the 'peace and quiet' then they complain they don't have all the things happenin' like they do in the city. AND, they think we are a bunch of uneducated country bumpkins. It makes me so mad. If they LIKED the chaos of the city why didn't they stay there? I moved to my town because I LIKED the peace and quiet. I didn't move to my town with the intent to change it. GEEZE!!!


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I ordered the Ultimate Sketch Pad with plans to use it with a group of kids in a week. MJM had the manufacturer ship directly to me. I received the...Read More ->
I needed help with a magic item. Once again, I was given an excellent prompt and honest reply. This is my favourite place to buy magic.Read More ->


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Twitter and Teenagers: An Interview With Gili Rusak
November 19, 2013
Gili Rusak is a junior in high school. She won an Honorable Mention 2013 Addiction Science Award. Read More »0 Comments
Write a Song To Promote Healthy Decisions
October 29, 2013
Recently, NIDA met with its Teen Advisory Group—a group of diverse teens from around the country—to talk about pop culture, celebrities, and drugs. Read More »2 Comments
Sports Supplements: Not a Safe "Quick Fix"
September 24, 2013
When working out or playing sports, you may feel like you want to up your game. There are lots of sports products out there that claim to help you run faster, be stronger, or play longer—but be careful. Read More »3 Comments
Thoughts on Recovery: Rhonda's Story
September 17, 2013
Rhonda started abusing drugs when she was 14 years old. She entered treatment for addiction when she was 19. Now at age 21, she has been drug free for almost 2 years, attends college, and enjoys time with her two children. Read More »1 Comment
Concert Goers Overdose on Molly
September 05, 2013
MDMA, or Molly, is suspected in the death of 2 people who attended Electric Zoo—a 3-day f Read More »4 Comments


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My Favourites: Weddings
by Jen Grantham
I'm getting married IN EIGHT DAYS. There's a lot of stuff to do before then! We are getting married in my parents' backyard in Barrie, North of Toronto, and my awesome friend Stacey Newman is going to be my wedding photographer. Here are some of my favourite wedding photos available to license on Stocksy. 30 […]
Categories: Blog, My Favourites, Stock Photography • Tags: Stocksy, Weddings


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I Love Hakius-haiku
Personal Stories, Advice, and Support 23 People
Under The Mermaid'S CrownGrinding, shouting, music Smiling faces, rich aromas, conversations Lovers, friends, strangers Relax, unwind, sun's low in sky
SleepingTiger 51-55, M 0 May 10, 2013
My HaikuI'm working on writing my own! Please share your favorite Haiku/Hakius Be inspired to write your own!!!!!!
stigmafree 31-35 0 Nov 30, 2009
Forget Me NotThings go unnoticed, soon trampled underfoot. Hello death.
PrettyOldSoul 41-45, F 13 Responses 0 May 22, 2011
IIthe bright moon at night I can't even describe it I just sit and stare
BodhiSvaha 22-25, M 3 Responses 0 Jan 18, 2011
Iin the cold silence ten black birds perch on a branch then fly to the sky
BodhiSvaha 22-25, M 0 Dec 1, 2009
The ConventionAtop Ayres Rock. A commotion . A convention of Bunyips...
David938 56-60, M 1 Response 0 May 27, 2011
Related Experiences
The heart is sheer love The heart is precious, treasured The heart shelters all I love your brilliance Every thing you share I find The beauty which shines You are amazing Your...
SquirrellyGal2493 18-21 0 3 days ago
I am amazed by The light in your eyes that shines You are beautiful
SquirrellyGal2493 18-21 0 3 days ago
"a september bride" a september bride her hollow sounds fearfully echo on the leaf strewn trail with intonations of a blushing bride to be she makes a graceful vision obscured...
mudmen 46-50 0 Aug 25


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Serving your area
Serving your area
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1.7 Miles
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Latest review: "We have used matt's shop for 11 years and we can not say enough good about him and his servi..."
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Latest review: "I don't live in woodstock,Ga.. but I'm there alot and everytime I'm there I have to go to to..."
16.4 Miles
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About the AuthorTiffany Bolk
tbolk Minneapolis, MN
I have my BFA from the Minneapolis College of Art and Design and my MFA from Cranbrook Academy of Art, both are in photography.
Publish Date December 07, 2008
Dimensions Small Square 40 pgs Premium Paper, matte finish
Category Parenting & Families
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Infrared Satellite
Chambersburg, PA 17201
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Dangerous thunderstorms will rumble today from the Tennessee Valley into the Northeast. Outdoor activities may be…More >
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You too can help save our planet and put money back in your wallet. Learn how you can take the first steps to reduce your environmental impact, including driving green, easy ways you can conserve water, and energy saving tips. To learn more and discover the benefits of going green, visit WeatherBug's green living section. More >
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"The hero is sexy," or some variation, I see a lot when reading reviews. I'm guilty of the same. It got me thinking. What makes a hero sexy? It's really hard to pigeon-hole as there are many characteristics that can make a hero sexy. Here's a list of what I came up with:
The White Knight - He's brave. He's strong. He's good. He rescues damsels, even if it's at an inconvenience to himself. He's true to his ideals. He wears uniforms -- whether it is chainmail or fire resistant or camouflaged, etc. -- and he's proud of the uniform he wears.
The Black Knight - He's not a polar opposite to the white knight -- like he and others think -- but he doesn't hesitate to work outside the law if it suits him. He doesn't stand for incompetence, rudeness, or laziness. He gets the job done and doesn't complain. He prefers to be alone and to work alone and can be easily irritated by the interference of others (read, heroine) but melts like butter with the right girl.
The Alpha - He's confident. He's popular with his buddies, the ladies, the elderly, kids, and dogs. He's got solid work ethics, strong morals, and treats his mother well. He can cut loose with the best of them, sweet talk a girl out of her undies in under a minute, and generally oozes sex appeal.
The Beta - He's quiet. He's secure in every way from his masculinity to his ideals to his career and in his lot in life. He's going to hold your hand in public, bring you to the weekly family barbecue, unabashedly carry your very girly purse, doesn't mind your hot-pink lipstick on his face, and will squire you about town in genuine delight. He's friend and lover all in one.
There are many more types, of course. The list is not definitive. Several of the qualities can easily describe each of the four hero types. But they are all sexy. What else makes a hero sexy in your book?


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(03/05/14) - Saginaw School Board members approved a revised deficit elimination plan, Tuesday, to lay off 36 teachers next year and 14 in 2016. The board also voted to close Heavenrich, Houghton and Reuben Daniels Schools, along with the Staff Development Center. Arthur Eddy Academy will re-open as a kindergarten through eighth grade school. Several families we talked to say they're excited about Arthur Eddy Academy reopening. Once a building full of life, Arthur Eddy Academy now sits empty. "That was a bad deal for them closing the school," said Mary Parham, a grandparent. It was closed last year as part of budget cuts, but 2014 brings talks of new beginnings for the vacant school. The district's board of education voted to reopen the building as part of a revised deficit elimination plan. "It really needs to be open," Parham said. Parham plans to send her grandson to Arthur Eddy as soon as the doors open. "Kids to need to go back to their own schools," she said. Helen Browning is overjoyed by the possibility of having an operating school back in her neighborhood. "I love the school. I sent my children there, some of my grandkids and nieces and nephews," she said. "We need our school for our children in school so they can get jobs." She recently transferred her granddaughter out of the Saginaw Public School district, but says she'll return to Arthur Eddy if all goes as planned. "I'd be glad to send her there. She'd just walk across the street and I'd keep a better eye on her," she said. More students could equal more hope for a district struggling with enrollment and financial problems.
ABC12 Main Station810-233-3130
Mailing Address:2302 Lapeer RoadFlint, Michigan 48503


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More than 2,000 pieces of clothing donated to homeless people in Bournemouth (From Bournemouth Echo)
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More than 2,000 pieces of clothing donated to homeless people in Bournemouth
11:00am Monday 14th April 2014 in News By Gayle McDonald
KIND-HEARTED members of the public have donated more than 2,000 pieces of clothing to help people in need.
In October, The Zipyard in Winton launched an appeal asking for customers to donate clothes for homeless people across Bournemouth. Six months later the owners of the clothing repair shop said they have been amazed at the response.
"We had a massive response – more than 2,000 items have been donated since October," exp-lained shop owner Kevin Old.
He added: "We were collecting clothing for the homeless and distributing it via Bournemouth Food Bank, which is also Bourne-mouth clothing bank.
"We were having to arrange daily pick-ups. We really didn't anticipate the response from our customers."
Last week the mayor of Bournemouth, Councillor Rod Cooper, who backed the campaign when it was first launched in the fall, visited the shop to congratulate the team for their hard work.
And regular Zipyard customer Liz Fackrell was given a brand new TV after winning a prize draw which ran alongside the appeal.
"Liz is one of our regular customers who donated to the appeal," Mr Old said.
"Everyone who donated had the chance to enter the draw and the winner was picked out of a hat."
Debbie Bramley, manager at Bournemouth Foodbank, said the clothes are being passed on to those in need.
"People have been very generous as they are with food," she said.
"We launched the clothing bank last year and The Zipyard are the first people to help us with it.
"People are coming in and taking the clothes they need."
Mr Old said the appeal has now ended but will be re-launched later in the year.
The 51-year-old said: "Obvious-ly now the weather has changed the campaign has ended now but we will definitely start up again in October."
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