text: ESPN Feed: junior seau http://assets.espn.go.com/i/tvlistings/tv_espn_original.gif ESPN en-us 10 ESPN Inc. http://espn.go.com/ Copyright 2010 ESPN Inc. Several research groups competed to study Junior Seau's brain after he died. Did the NFL help pick the winner?]]> April 27, 2013 03:59:45 PDT Former NFL running back Leroy Hoard discusses coping with headaches, memory loss and depression and explains why he must never forget Andre Waters, Dave Duerson and Junior Seau, three former NFL players who committed suicide.]]> January 27, 2013 06:24:02 PST From NFL veterans, like Jacob Bell, to newcomers, like Chad Diehl, some players are choosing to walk away from football over concerns about their long-term health.]]> August 27, 2012 02:24:22 PDT John Parrella, member of the 1994 San Diego Chargers AFC Champions team, remembers Junior Seau and the other teammates he's lost from that team.]]> May 08, 2012 07:15:21 PDT


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Great place to stay short-term, clean hotel, staff was pretty friendly, easy to get to once you knew the roads, no problems checking in and out. Great if you want to explore Hamilton and have a cheaper place to stay, neighborhood is a bit sketchy, but as long as you stay to good safety measures you're in great shape!
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Priceline and BookingOdigeoWL so you can book your Budget Inn 2000 reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
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- Budget Inn 2000 Hotel Hamilton
- Budget Hotel Hamilton
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West Lafayette News
Local news for West Lafayette, OH continually updated from thousands of sources on the web.
Saturday Aug 16 | Daily-Jeff.com
Body recovered from Tuscarawas River in Coshocton County
Authorities in Tuscarawas and Coshocton counties have confirmed that a body has been recovered from the Tuscarawas River but have not confirmed the identity.
Happy 98th birthday Marie Jackson of Cambridge
Earlier this year, Mrs. Jackson attended the 80th Salem-Liberty High School Alumni Banquet.
17-year-old missing after last seen in the Tuscarawas River
Dive teams from various nearby fire departments continued the search Monday for a 17-year old male who possibly drowned in the Tuscarawas River Sunday afternoon.
Hornbeck-Milstead family reunion is held in Byesville
The 2014 Hornbeck - Milstead reunion took place on Aug. 2 at Byesville Village Park, with 62 family members and two guests in attendance.
We've heard the stories or read articles about how animals can help military veterans living with combat-related post- traumatic stress disorder adjust back into civilian life and lead a more productive life.
West Lafayette News, Events & Info
Updated: Sat Aug 16, 2014 04:52 pm
Copyright © 2014 Topix LLC


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JESUS TAKE THE WHEEL: A court employee committed suicide Thursday morning inside the Hugo Black federal courthouse in downtown Birmingham, Ala.
MyFoxAL: Birmingham Police Sgt. Johnny Williams said the man carried a gun inside a clerk's office on the first floor and shot himself. The man was transported to a local hospital where he died a short time later.
Peter Montgomery, a witness inside the courthouse, told FOX6 News reporter Alan Collins he heard a gunshot from inside a clerk's office on the first floor. Moments later, he saw an elderly man with blood pouring from his head.
UPDATED 2:20 p.m. EST (12/13/12): The court employee has been identified as David Lee Williams, director of building services at the Hugo L. Black Federal Courthouse. He reportedly went into the office of U.S. Clerk of Court Sharon Harris and shot himself in the forehead. http://hinterlandgazette.com/2012/12/david-lee-williams-commits-suicide-hugo-black-federal-courthouse-birmingham-al.html
Latest posts by Janet Shan (see all)
- AG Eric Holder Urges Peace and Non-Violence in Ferguson Over Michael Brown Shooting - August 19, 2014
- Maria Fernada Godinez ID'd as Innocent Bystander Killed by OPD Officer Eduardo Sanguino - August 19, 2014
- Racist Kansas City Cop Marc Catron Facing Review Over Michael Brown Facebook Posts - August 19, 2014


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CREED Original Santal Eau de Parfum, 75ml
- Product information
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Product information
Original Santal is a totally new take on a trueclassic ingredient. Although Sandalwood underpins this fragrance it is woven through with other woods and aromatic herbal and spice notes which give it a very contemporary appeal.
- Top notes: Orange Tree Absolute, Jamaican Ginger
- Heart notes: Lavender, Peppermint, Rosemary, Juniper Berry
- Base notes: Sandal wood from Mysore, Virginian Cedar, Absolute Vanilla, Benzoin from Thailand, Ambergris, Tonkin Musk
- Brand
- Eligible for International Delivery
- Fragrance Price per 100ml
- £213.33
- Fragrance Type
- Eau de Parfum
- Scent
- Woody
- Size
- 75ml
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Wildlife Classes & Trainings
Eagle's View: A Guided Nature Walk
Saturday June 14th, 10:30am or 1 pm
Ages 8 and up
Seek the home of the mighty eagle on this epic journey through the cultural history and landscapes of Seward Park. Under the canopy of the magnificent forest you will learn about the plants, animals and ecosystems that support eagle and his family. On the shores of lake Washington you will touch the sedimentary bed rock that roots his humble home and learn about the tectonic forces that shaped our city. After a hike across the park you will have a chance to use our viewing scope to check out one of the two eagle nests in the park and search for baby eagles. Guided by expert naturalist Mikhaila Gonzales this eagle viewing opportunity only comes once a year so get your tickets early here. http://www.brownpapertickets.com/event/706781


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CENTERVILLE, Tenn. – An investigation is underway in Hickman County after authorities discovered the badly dismembered body of a missing 19-year-old early Wednesday morning not far from Centerville's town square.
Tennessee Bureau of Investigation spokesperson Kristin Helm told Nashville's News 2 the remains of Alphonso "Bonzo" Waters were found covered in debris in a ravine in a wooded area behind a home on Columbia Avenue.
Officers were led to the area after receiving a tip from a caller around 1 a.m.
Waters' twin brother, Alonzo, told Nashville's News 2 his brother had been missing for at least three weeks but wasn't reported missing until about a week ago.
Alonzo Waters said his brother had a history of drug use and that likely led to his untimely death.
Waters said his brother was beaten to death with a hammer while sleeping on an acquaintance's couch.
He said his brother's killers then dismembered him and moved his remains to the ravine where they were found earlier on Wednesday.
I'm speechless. I don't know what to. I think anyone who lost their twin would feel [this way]. They would probably be speechless too," Waters said.
According to Waters, police have two people, a male and a female, in custody in connection to his brother's death.
Police in the town of Centerville, about 60 miles southwest of Nashville, have said little about what might have happened and declined to comment on the persons in custody.
As of Wednesday evening, the TBI said no one had been charged with the murder.
441 Murfreesboro Road Nashville, TN 37210
Telephone: 615.369.7222
Fax: 615.369.7329
Email: firstname.lastname@example.com


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A delicious double IPA home brew from B in Chicago. This is what Tuesday is all about.
Ryan Adams. Fox Theatre. Boulder. He is back, ladies and gents, and at the top of his game. Welcome back, DRA. 080714
On Saturday, July 28th my friend Emily and I went out to tackle the three 14ers just south of Breckenridge, Mt. Democrat, Mt. Cameron and Mt. Lincoln. I wasn't sure I could do even one but I managed to do all three! It was awesome. Who would have thought that my first 14er turned into three 14ers in one day! 072814
I was FINALLY able to catch Jason Isbell in concert and it was absolutely breathtaking. The Hard Working Americans were pretty good too but I wish it was a Jason Isbell solo show and that he could have played for hours. Can't wait to see him again. 072314p
So, um, yeah. This totally happened on Sunday Night. And it was AWESOME!!!! I was a giddy giddy giddy little girl. 080314
I work with artists pretty much every day/every week, but in my entire career I haven't worked with a band that I absolutely positively loved growing up. Friday, I had that chance with Better Than Ezra and it was awesome! They even helped me wish my sister Happy Birthday since she couldn't be there herself! 080114
Coney at Night - Olly Peacock
I love this photo and I love this band (Gomez.)
Typical Monday night. Delicious. Thanks @brian_miller.
Typical night in Denver, a trip to a brewery. This time Crooked Stave.
Final destination on Emily and my trip to Aspen and back was a jaunt up the highest paved road in North America. Not a road for the weak-stomached, as the switch backs were rather frightening but it was so much easier, and faster, than actually climbing a 14er!


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Sign up for Yardbarker's daily Top 10 newsletter, the Morning Bark! Customize to get news on your favorite sports and teams.
Fullback Darrel Young believes there'll be a role for him in new offense
Over the course of the past four seasons, fullback Darrel Young has proved his worth to the Washington Redskins both as a lead blocker and on special teams. Former offensive coordinator Kyle Shanahan often proclaimed that Young ranked among the best fullbacks in the NFL. In the past two seasons, Young helped pave the way for a rushing attack that ranked among the league leaders...
Via Pro Sports Daily
July 13, 2014 | Discuss
Young's third TD lifts Redskins in OT
Darrel Young had carried the ball only twice all season. He had scored only three touchdowns in his three-plus years in the NFL. Now he's in the spotlight. Young scored three times Sunday, including a 4-yard run in overtime that gave the Washington Redskins a 30-24 win over the San Diego Chargers. Young stormed his way into the end zone 6:01 into the extra period, with the...
Via AP on Fox
Young has 3 TDs, Redskins top Chargers 30-24 in OT
Darrel Young scored on a 4-yard run in overtime Sunday, the third touchdown of the game for the little-used fullback, giving the Washington Redskins a 30-24 win over the San Diego Chargers. Young, who had carried the ball only twice all season entering the game, also had a pair of 1-yard touchdown runs for the Redskins (3-5), who scored on the opening drive of the extra period after...
Via AP on Fox
Darrel Young scores three touchdowns in Redskins win
Darrel Young had one rushing touchdown over his first 52 games in the NFL. On Sunday the Washington Redskins fullback vultured three touchdowns as the Redskins eeked out a 30-24 overtime win against the San Diego Chargers. The Redskins found that the fullback out of the i-formation was a weekness for the Chargers and took advantage of it with Young on Sunday. Young netted just 12...
Via Tireball.com
Young, NFL To Visit Deployed Military Units
I'm not sure if Redskins fullback Darrel Young is a fan of literature, but his life has captured the essence of Robert Frost's "The Road Not Taken." Coming out of Villanova as a linebacker, Young went undrafted and unsigned in the 2009 NFL Draft. Most players in that position would give up on their dreams, but not Young. When Young finally did get his chance in training�...
Via Redskins Blog
January 18, 2012 | Discuss
Darrel Young's first rushing TD comes against childhood team
Redskins fullback Darrel Young scored the first rushing touchdown of his career in Sunday's 23-10 victory over the New York Giants, a six-yard run that gave Washington a 17-0 lead in the second quarter. "It was an honor," Young said. "I know my family's watching and stuff like that. I wish they were on the sideline with me." Read full article >>
Via Redskins Insider
December 19, 2011 | Discuss
Redskins-Jets: Darrel Young is out
The Washington Redskins will be without starting fullback Darrel Young as they take on the New York Jets. Young suffered a concussion in last week's victory over the Seattle Seahawks. He passed baseline tests for a return and took some snaps Friday, but the team chose to keep him sidelined for this week's game as a precaution. Read full article >>
Via Redskins Insider
December 04, 2011 | Discuss
Effects of FB Darrel Young's concussion appear mild
Washington Redskins fullback Darrel Young doesn't appear to have any lingering effects from a mild concussion he suffered in the team's 23-17 victory over the Seattle Seahawks on Sunday, according to a person with knowledge of the situation. The second-year pro will continue to be evaluated, but there is a good chance he will return to action this week. Read full article >>
Via Redskins Insider
November 29, 2011 | Discuss
Darrel Young's Blog: We Will Get Better
Redskins fullback Darrel Young has been a real success story over the last two years, making the transition from a FCS linebacker to above-average NFL fullback. His emergence on the field has led to his emergence in the locker room, and the inevitable emergence in the media. Following Sunday's loss to the Cowboys, he took to Twitter to promote his personal blog on his personal...
Via Redskins Blog
November 25, 2011 | Discuss
Young Gives Personal Thanks To Veterans
In honor of the upcoming Veteran's Day celebrations, Redskins fullback Darrel Young spent his Tuesady at the Westin Hotel at Tysons Corner for the "Salute Our Heroes" luncheon." Young joined former Redskin Rick "Doc" Walker at the event, which was hosted for military members and their families. Events with veterans, or current military personnel, have special importance...
Via Redskins Blog
November 09, 2011 | Discuss
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Product Recall: Voluntary recall of 260 cases of Velveeta Original Pasteurized Recipe Cheese Products. Click Here.
HEAT oven to 400ºF.
PLACE pizza crust on baking sheet. Mix pizza sauce, ketchup and mustard; spread onto crust.
TOP with franks and cheese.
BAKE 10 to 15 min. or until crust is golden brown and cheese is melted.


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|Signal Transduction
|Home > Research > Signal Transduction
"The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway." (Source: MeSH)
Figure: An overview of major signal transduction pathways
Source: https://en.wikipedia.org/wiki/File:Signal_transduction_pathways.svg (License: CC BY-SA 3.0)
Menu: Signal TransductionWeb Resources: Signal Transduction and Cancer
Latest Research Publications
Web Resources: Signal Transduction and Cancer (3 links)
Lecture slides from Deepika Tripathi
Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction
Educational animation which explains the mechanism of abnormal signal transduction resulting in uncontrolled cell proliferation. This animation also provides an overview of the potential targets of anticancer therapies.
Yale Cancer Center
Overview of the Signal Transduction programme at Yale University
Latest Research Publications
This list of publications is regularly updated (Source: PubMed).
Cellular mechanisms and physiological consequences of redox-dependent signalling.
Nat Rev Mol Cell Biol. 2014; 15(6):411-21 [PubMed] Related Publications
Related: Cancer Prevention and Risk Reduction
Overactivated neddylation pathway as a therapeutic target in lung cancer.
J Natl Cancer Inst. 2014; 106(6):dju083 [PubMed] Related Publications
METHODS: NEDD8-activating enzyme (NAE) (E1) and NEDD8-conjugating enzyme (E2) expression and global-protein neddylation were examined by immunohistochemistry, immunoblotting, and real-time polymerase chain reaction analysis. Cell proliferation, clonogenic survival, migration, and motility in vitro, as well as tumor formation and metastasis in vivo, were determined upon neddylation inhibition by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Survival was analyzed with Kaplan-Meier methods and compared by the log-rank test. All statistical tests were two-sided.
RESULTS: The entire neddylation pathway, including NEDD8-activating enzyme E1, NEDD8-conjugating enzyme E2, and global-protein neddylation, is overactivated in both lung adenocarcinoma and squamous-cell carcinoma. Compared with lung adenocarcinoma patients with low expression, those with high expression had worse overall survival (NEDD8-activating enzyme E1 subunit 1 [NAE1]: hazard ratio [HR] = 2.07, 95% confidence interval [CI] = 0.95 to 4.52, P = .07; ubiquitin-conjugating enzyme E2M (UBC12): HR = 13.26, 95% CI = 1.77 to 99.35, P = .01; global protein neddylation: HR = 3.74, 95% CI = 1.65 to 8.47, P = .002). Moreover, inhibition of neddylation by the NAE inhibitor MLN4924 statistically significantly suppressed proliferation, survival, migration, and motility of lung cancer cells in vitro and tumor formation and metastasis in vivo. At the molecular level, MLN4924 inactivated Cullin-RING E3 ligases, led to accumulation of tumor-suppressive Cullin-RING E3 ligase substrates and induced phorbol-12-myristate-13-acetate-induced protein 1 (NOXA)-dependent apoptosis or cellular senescence.
CONCLUSIONS: Our study highlights the overactivated neddylation pathway in lung cancer development and as a promising therapeutic target.
Related: Lung Cancer
Connections of nicotine to cancer.
Nat Rev Cancer. 2014; 14(6):419-29 [PubMed] Related Publications
Related: Lung Cancer
Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.
J Natl Cancer Inst. 2014; 106(6):dju085 [PubMed] Article available free on PMC after 01/06/2015 Related Publications
METHODS: Among 5887 PCa patients (704 PCa deaths) of European ancestry from seven cohorts in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium, we conducted Cox kernel machine pathway analysis to evaluate whether 530 tagging single nucleotide polymorphisms (SNPs) in 26 IGF pathway-related genes were collectively associated with PCa mortality. We also conducted SNP-specific analysis using stratified Cox models adjusting for multiple testing. In 2424 patients (313 PCa deaths), we evaluated the association of prediagnostic circulating IGF1 and IGFBP3 levels and PCa mortality. All statistical tests were two-sided.
RESULTS: The IGF signaling pathway was associated with PCa mortality (P = .03), and IGF2-AS and SSTR2 were the main contributors (both P = .04). In SNP-specific analysis, 36 SNPs were associated with PCa mortality with P trend less than .05, but only three SNPs in the IGF2-AS remained statistically significant after gene-based corrections. Two were in linkage disequilibrium (r 2 = 1 for rs1004446 and rs3741211), whereas the third, rs4366464, was independent (r 2 = 0.03). The hazard ratios (HRs) per each additional risk allele were 1.19 (95% confidence interval [CI] = 1.06 to 1.34; P trend = .003) for rs3741211 and 1.44 (95% CI = 1.20 to 1.73; P trend < .001) for rs4366464. rs4366464 remained statistically significant after correction for all SNPs (P trend.corr = .04). Prediagnostic IGF1 (HRhighest vs lowest quartile = 0.71; 95% CI = 0.48 to 1.04) and IGFBP3 (HR = 0.93; 95% CI = 0.65 to 1.34) levels were not associated with PCa mortality.
CONCLUSIONS: The IGF signaling pathway, primarily IGF2-AS and SSTR2 genes, may be important in PCa survival.
Related: Prostate Cancer USA
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
J Biomed Nanotechnol. 2014; 10(7):1217-30 [PubMed] Related Publications
Related: MKI67 Stomach Cancer Gastric Cancer TP53 TET1 TET2 gene
GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.
Proc Natl Acad Sci U S A. 2014; 111(19):E2008-17 [PubMed] Article available free on PMC after 13/11/2014 Related Publications
Related: Cancer of the Pancreas Pancreatic Cancer RET
Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells.
Anticancer Res. 2014; 34(5):2095-104 [PubMed] Related Publications
MATERIALS AND METHODS: The cytotoxicity of BMP2-knockdown, dorsomorphin derivatives, and microRNAs was tested in transformed and non-transformed lung cells. Microarray analyses of 1,145 microRNAs in A549 lung adenocarcinoma cells and two other transformed lung cell types relative to BEAS-2B bronchial epithelial cells were performed.
RESULTS: Reduced BMP2 synthesis inhibited A549 cell growth. The dorsomorphin derivative LDN-193189, but not DMH1 or DMH4, was strongly cytotoxic towards A549 cells, but not towards BEAS-2B cells. Microarray analysis revealed that 106 miRNAs were down-regulated and 69 miRNAs were up-regulated in the three transformed lines. Three down-regulated miRNAs, hsa-mir-34b, hsa-mir-34c-3p, and hsa-miR-486-3p, repressed a BMP2 reporter gene and were cytotoxic in A549 cells, but not towards BEAS-2B cells.
CONCLUSION: The observed cytotoxicity suggests that reducing BMP signaling is a useful line of attack for therapy of lung cancer.
Related: Lung Cancer
Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma.
Biochem Biophys Res Commun. 2014; 448(1):76-82 [PubMed] Related Publications
Related: Kidney Cancer
Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas.
Hum Pathol. 2014; 45(5):984-93 [PubMed] Related Publications
Related: Dermatofibrosarcoma Protuberans AKT1
PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma.
Proc Natl Acad Sci U S A. 2014; 111(17):6383-8 [PubMed] Article available free on PMC after 13/11/2014 Related Publications
Related: Apoptosis PDGFB gene Imatinib (Glivec) Dasatinib (Sprycel)
Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer.
Prostate. 2014; 74(8):829-38 [PubMed] Related Publications
METHODS: Gene and protein expression levels were evaluated by quantitative real-time polymerase chain reaction and Western blot analysis, respectively. We evaluated the sensitivity of prostate cancer cells to taxanes using cytotoxicity assays.
RESULTS: Natural taxane paclitaxel from Taxus brevifolia activated the Raf-1/extracellular signal-regulated kinase (ERK) pathway, leading to an activation of ribosomal S6 kinases (RSK)/YB-1 signaling. Activated Raf-1/ERK pathway was blunted by YB-1 knockdown in prostate cancer cells, indicating regulation between Raf-1/ERK signaling and YB-1. In addition, ERK or RSK was activated in taxane-resistant prostate cancer cells, resulting in YB-1 activation. YB-1 knockdown as well as RSK inhibition using RSK-specific siRNA or the small molecule inhibitor SL0101 successfully blocked activation of YB-1, leading to suppression of prostate cancer growth and sensitization to paclitaxel.
CONCLUSIONS: Taken together, these findings indicate that RSK/YB-1 signaling contributes to taxane resistance, and implicate the therapeutics targeting RSK/YB-1 signaling such as RSK inhibitor as a promising novel therapy against prostate cancer, especially in combination with taxane.
Related: Paclitaxel Prostate Cancer
Copper is required for oncogenic BRAF signalling and tumorigenesis.
Nature. 2014; 509(7501):492-6 [PubMed] Related Publications
Related: Lung Cancer BRAF gene Vemurafenib (Zelboraf)
Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.
Pharmazie. 2014; 69(3):229-33 [PubMed] Related Publications
METHODS: The acute monocytic leukemia cell line THP-1 was used as in vitro cell model to explore the anti-leukemia effects and mechanisms of curcumin. Cell proliferation was measured by MTT assay, cell apoptosis bodies were observed using a light microscope, cell apoptosis rate was evaluated by flow cytometry, and the expression alterations of growth-sinaling proteins were detected by Western blotting.
RESULTS: Curcumin inhibited cell proliferation and induced cell apoptosis in time- and dose- dependent manner in THP-1 cells. Curcumin significantly inhibited the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.
CONCLUSION: This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously. Our data suggest that curcumin is a promising anti-tumor agent in acute monocytic leukemia.
Related: Apoptosis Acute Myeloid Leukemia (AML)
Fibroblast growth factor signaling in liver carcinogenesis.
Hepatology. 2014; 59(3):1166-73 [PubMed] Related Publications
Related: Liver Cancer
Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.
Proc Natl Acad Sci U S A. 2014; 111(14):5349-54 [PubMed] Article available free on PMC after 08/10/2014 Related Publications
Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis.
Proc Natl Acad Sci U S A. 2014; 111(14):5343-8 [PubMed] Article available free on PMC after 08/10/2014 Related Publications
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
Nat Genet. 2014; 46(5):444-50 [PubMed] Article available free on PMC after 01/11/2014 Related Publications
Related: Brain Stem Glioma - Childhood NTRK1 gene NTRK2 NTRK3 gene
Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells.
Am J Physiol Gastrointest Liver Physiol. 2014; 306(10):G863-72 [PubMed] Article available free on PMC after 15/05/2015 Related Publications
Related: Cancer of the Esophagus Esophageal Cancer
Metformin suppresses sonic hedgehog expression in pancreatic cancer cells.
Anticancer Res. 2014; 34(4):1765-9 [PubMed] Related Publications
MATERIALS AND METHODS: BxPC3 human pancreatic cancer cells were treated with metformin, and Sonic hedgehog (Shh) mRNA and protein levels were examined by real time reverse transcription-polymerase chain reaction, immunohistochemistry and immunoblotting, respectively. The effect of metformin on Shh levels was also examined in three other cancer cell lines.
RESULTS: Shh protein and mRNA expression was suppressed by metformin in BxPC3 cells. This phenomenon was further confirmed in three other cancer cell lines. Shh mRNA expression was inhibited by metformin in a concentration-dependent manner in two cancer cell lines.
CONCLUSION: Metformin reduces the expression of Shh in several cancer cell lines including pancreatic cancer cell.
Related: Cancer of the Pancreas Pancreatic Cancer
Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways.
Anticancer Res. 2014; 34(4):1709-13 [PubMed] Related Publications
MATERIALS AND METHODS: 3H-Thymidine incorporation assays were performed to address Huh7 and liver cancer stem cell (LCSC) inhibition using FH535 and sorafenib, alone and in combination. Calcusyn analysis was used to calculate the combination index (CI). A western blot assay was performed to check for potential targets.
RESULTS: FH535 and sorafenib caused inhibition of Huh7 and LCSC. Combination therapy was significantly better than monotherapy in inhibition of HuH7. Combination with sorafenib and FH535 was found to be synergistic in inhibition of LCSC with a CI of less than 1. The western blot assay demonstrated enhanced cleaved poly (ADP-ribose) polymerase (PARP) and inhibition of cyclin D1, B-cell lymphoma 2 (Bcl2), survivin and cellular myelocytomatosis oncogene (c-MYC).
CONCLUSION: FH535 and sorafenib combination produced synergistic effect on inhibition of HCC and LCSC. Our study demonstrated that FH535 can induce apoptosis in these two different hepatocellular carcinoma (HCC) cell lines.
Related: Liver Cancer BIRC5 Sorafenib (Nexavar)
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Anonymous asked: Love your tumblr! Whats your favorite camera to use for shoots?
Thanks. I shoot with a Canon 5D3. I am not a brand fanboy so really any modern camera is likely to be great. I think the Mark 3 has the best balance of resolution, autofocus, features, and price. The D800 is also a great camera. Fuji and Sony mirrorless systems are awesome. And if you had the money Hasselblad or Phase One medium format cameras are all amazing in certain circumstances. Choose the right tool for the job.
But overall, I think the 5D3 is a fantastic all around camera that can accomplish any job.


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The Top 10 In Action Sports
01We Tried A New Yoga Class... In The Middle Of A Canal
0223 Weird and Wonderful New Bike Inventions For 2015
03Guard Dogs and Phallic Objects: 6 Weird Ways To Stop Your Bike Getting Stolen
04The Biggest Dirt Quarter Pipe Ever Built is Back. And This Time the World's Best BMXers Have A Ticket To Ride...
05'I Had Nightmare Visions of Being Gunned Down Wearing Nothing But My Speedos…'
0615 Unbelievably Weird Skate Inventions That You Never Knew You Needed
07Surfers Beware! They're Deadly, They're Lurking In The Water, But You Can't See Them...
08How To Make Your Girlfriend/Boyfriend Hate Your Sport
09Winter Is Coming: The World's Best Snowboarders Are Back - And They're Absolutely Ripping.
102014: The Year British Mountain Bikers Showed the World Who's Boss
"Beyond The Surface" A Documentary Film Project
A Surfing video by surfersmag - 5,610 views
Ishita Malaviya, India's first female surfer, is joined by a unique and talented group of women –
Crystal Thornburg-Homcy, Liz Clark, Lauren Hill, Emi Koch, and Kate Baldwin. With unshakable determination for a better world they will travel through Southern India documenting the ways in which surfing, yoga, and ecological creativity are bringing hope and fueling change for local people and the Planet.
The saturated hues of India set the scene for this documentary that will touch upon eco-tourism, youth and women's empowerment, biocentrism and personal growth. They will be integrating these causes with the pursuit of India's perfect waves, highlighting the undeniable power of surfing to bring joy amongst suffering. Documentary-style interviews with the local Indian community, filmed by award winning cinematographer, Dave Homcy, will capture this rare and inspiring endeavor with the goal of sharing these stories with the global surf community and beyond. Homcy is best know for critically acclaimed work in Sliding Liberia, Surfwise, A Broke Down Melody, El Mar Mi Alma, Come Hell or High Water, One Track Mind, Shelter, and Dear and Yonder.
They intend to bring a spark of hope to the people we meet who face social disparity and suffering, and empower those without voices. All the while, they will discover more about themselves, exchange life experiences and – through the medium of film – inspire others to seek a deeper connection to their fellow humans and to the wonder of nature.


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What, exactly, is left for the Trade Development Council to develop?
Posted Apr 14th 2011, 12:00am
... with Jake van der Kamp This week sees the confluence of three important fairs as the Hong Kong Trade Development Council capitalises on its reputation for hosting some of the world's ... merchandise exports. We also subsidise the Trade Development Council with a special tax, the trade declaration charge, because, even with the Convention and Exhibition Centre at its disposal, ...http://www.scmp.com/article/965065/what-exactly-left-trade-development-council-develop
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Malaysian PM echoes Beijing's call for joint development in South China Sea
Posted Jun 05th 2013, 12:00am by BLOOM
... Bloomberg in Bangkok Malaysian PM says it's better to share prosperity rather than row over South China Sea resources Najib echoes Beijing's call for joint development Malaysian Prime Minister Najib Razak appeared to side with Beijing as he called for claimants in the South China Sea to jointly develop resources to avoid conflict and prevent "extra-regional ...http://www.scmp.com/news/asia/article/1253564/malaysian-pm-echoes-beijings-call-joint-development-south-china-sea
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China to ramp up development on disputed Paracel island
Posted Nov 11th 2012, 02:50pm by AFP
... Agence France-Presse in Beijing China is to ramp up development on a disputed South China Sea island, a local government chief has said, in a move likely to stoke a growing territorial row with its neighbours. The development of roads, water supply and drainage systems will be stepped-up in the new "capital" city of Sansha on Yongxing, one of the islands that make up the disputed ...http://www.scmp.com/news/china/article/1079962/china-ramp-development-disputed-paracel-island
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Major development plan for Woody Island unveiled
Posted Nov 04th 2012, 12:00am by Minnie Chan
... Minnie Chan email@example.com Major development for Woody Island Beijing will spend more than 10 billion yuan (HK$12.3 billion) to upgrade military and civilian infrastructure at its ... not merely military purposes," said Li Jie, a Beijing-based military expert. "Both the central and local governments want to develop ecotourism in Sansha, but now they just have one coastal ...http://www.scmp.com/news/china/article/1074996/major-development-plan-woody-island-unveiled
UK luxury developer opens first HK office
Posted Jul 18th 2012, 12:00am
... Peggy Sito email@example.com Asian investors' strong demand for London homes has spurred the Berkeley Group, a British luxury developer, to open a Hong Kong office to serve ... will be its Abell & Cleland House development in Westminster, London. The two-block development will comprise 206 one- to three-bedroom flats. Berkeley is now marketing homes of 571 sq ft to 1,849 ...http://www.scmp.com/article/1007082/uk-luxury-developer-opens-first-hk-office
Learning outside the class aids students to develop
Posted May 14th 2012, 12:00am
... there is an acceptance of differences so to study there is an opportunity for young people to develop a sense of pride in the mix of East and West inside them and be proud of it,' says Pan. ...http://www.scmp.com/article/1000940/learning-outside-class-aids-students-develop
Fewer home sites available for developers
Posted Feb 03rd 2012, 12:00am
... Yvonne Liu, Paggie Leung and Joyce Ng The Hong Kong government plans to make fewer residential sites available to developers this year than last, leading to fewer flats being built, a move ... of the 47 sites are new; the rest were offered previously but not sold. The latest list includes two sites from the Kai Tak Development, home of the old airport, the first time private housing sites ...http://www.scmp.com/article/991551/fewer-home-sites-available-developers
Developing talent in local arts scene is possible only with better funding
Posted Jan 05th 2012, 12:00am
... In the excellent article, 'Little chance to bloom' (January 2), many good points about the local arts scene were made. However, that only a relatively small percentage in groups such as the Hong Kong Philharmonic and the Hong Kong Ballet are loc ...http://www.scmp.com/article/989254/developing-talent-local-arts-scene-possible-only-better-funding
Planning ahead for public housing must include developing the New Territories
Posted Oct 14th 2011, 12:00am
... of land, more than 2,500 hectares, are needed. These can only be made available by developing the New Territories, which has 90 per cent of Hong Kong's total land mass. The planning ... I have long advocated the formation of a strategic planning advisory council to plan Hong Kong's future urban development. I hope that Hong Kong's next chief executive will have ...http://www.scmp.com/article/981861/planning-ahead-public-housing-must-include-developing-new-territories
A taste for enterprise developed in the kitchen
Posted May 02nd 2011, 12:00am
... into Asia and China market. Chan will stay on for three years to take charge of Asian business development. Why did you decide to merge SINOVA with ANT Group? ANT offered me a good price to take over my firm. In addition, they allowed me to stay on for three years to focus on strategies and business development for the Asian region, which suited me well. In a sense, I am back ...http://www.scmp.com/article/966620/taste-enterprise-developed-kitchen
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Is your year on track? If not -- now is a wonderful time to course correct a little and re-evaluate the goals you set for yourself in January. What inspired you to write them? Go back to that place and sit with them awhile. Forgive yourself if you are not where you hoped to be and remember, it is never, ever, ever too late to still go for what it is that you want and to follow your dreams.
The reason first love stories are so compelling to read is because there is something so powerful about a young love experience. Is it because it happens when our hearts are still innocent and pure -- before that first inevitable heartbreak? Or is it because once that huge flame dies out, a few warm embers remain to keep the memory aglow?
Disposable dating seems to lead to an ultra-casualness, a bunch of people pretending that opening yourself up to the possibility of feeling rejection and disappointment is no big deal. In reality, it is extraordinarily brave to bundle up all of our confidences and insecurities in a Friday night outfit and put them on display for someone else.


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Page 1 of 4
TIRUNELVELI: Former President A P J Abdul Kalam on Sunday held discussions on safety aspects of the Koodankulam project, even as locals intensified their protests saying they are not willing to enter into a dialogue with him.
KNPP officials said Kalam, who arrived here on Saturday night, began discussions with officials on Sunday morning and would also inspect the safety features of the plant.
Kalam, a votary of nuclear energy, had himself said he would visit all reactors across the coastal belts.
Interest Networkitimes | Email


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…Hands over 100 patrol vehicles, 150 patrol bikes to police
LAGOS—Governor Babatunde Fashola of Lagos State, yesterday, described the weekend terror alert issued by the United States of America, USA, Consul-General in the state as "inappropriate".
The US Consul-General in Lagos had warned her citizens in the country or those coming in to stay off some states and also alerted that some groups associated with terrorism allegedly planned to carry out an unspecified attacks against Sheraton Hotel, Lagos.
Fashola spoke after handing over 100 patrol vehicles, 150 patrol motorbikes, five Vans popularly called "Black maria" and one towing vehicle donated by the state Security Trust Fund, LSSTF at the state House, Alausa Secretariat, Ikeja.
The governor argued that; "The information violates the Universal Declaration of Human Rights of 1948; Freedom from fear. I think that there are channels of communication that information of that type can be shared without creating panic and I think that citizens of all nationals can be protected without throwing a cat among pigeons.
"I will hope that we are more circumspect in the way we share information and that our intentions are noble. This is very important at this time, what the country needs is more information in the right hands, to the right places. This will assist our agencies and government to overcome this difficult period and not disseminating information through the social media especially, in a way that there is no control and management. Anyone who does that does not mean well for the country."
The governor insisted that the release of such information had raised new dimension into the obligation of nations and governments around the world to ensure peace and to cooperate with one another.
Lamenting the gravity of the information Fashola said: "The fundamental freedom that seems to have gone out of our daily discuss, which is the freedom from fear and this was a freedom that was recognized in 1948 when the declaration of rights were been adopted as a global publication.
"At a local level, I have received information before that a particular commercial bank was about to be robbed. I did not go out and announce to the public that such act will be committed in the state. All I did was I called the security officials and what we did was to sleep inside the bank. The robbers came at night, and we apprehended them without the public idea except the bank manager who was aware on why we visited the bank and our mission," he added.
While commenting on security challenge, the governor described terrorism as a threat to humanity, calling for a concerted effort of all countries in tackling the menace.
Fashola said he was disturbed by the recent abduction of about 200 school girls in Chibok, Borno, and urged all Nigerians to unite to ensure their safe rescue.
On the distribution of patrol vehicles, the governor, appealed to Divisional Police Officers, DPOs to be proactive in their security check saying; "DPO's should constantly meet with their community to ensure that security challenges in their community are solved and nipped in the bud.
"All of these tools mean nothing unless we have dedicated men and women who choose to act professionally in the responsibility of law enforcement entrusted upon them.".


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Thoughts on the June 3 Election
Californians (at least a very small number of us) went to the polls yesterday (well, most of us mailed back our ballots and didn't actually go to the polls). Here are some thoughts, in no particular order of importance:
- Turnout was really, really, really low–even for a boring election like this one. Right now it looks like turnout among registered voters (who we think are likely to vote because they bothered to register) will be a mere 18.5%. In 2010 and 2006, registered turnout was 33%. This is voter participation looks like in an election where the most compelling statewide race is the Secretary of State contest and there are no big, sexy ballot initiatives to draw people's attention.
- At least locally, this election looks to be as close to an all-mail election as we've seen in a long time. Last week, over 42,000 mail ballots had been returned to the Registrar's office. As of this morning, the Registrar reports that just over 50,000 people voted in San Joaquin County. Even assuming that no more mail ballots were submitted (problematic), that means that about 85% of the ballots cast were cast through the mail.
- Unless I have missed something, there will be no minor party candidates on this fall's ballot. There will be a handful of No Party Preference candidates, but no minor party candidates were among the top two vote getters in any partisan contest.
- In 2012, the Democrats blew a great opportunity to pick up the 31st congressional district. The district tilts slightly Democratic in its presidential/gubernatorial voting and in its voter registration, but no Democrat appeared on the November ballot in 2012 because the Democrats could not coordinate and settle on a single candidate. They almost did it again this year. Pete Aguilar, the top vote getter among the four (!) Democrats in the district, received just 390 more votes than the second-place Republican, Lesli Gooch. Aguilar should win against Paul Chabot in November, though.
- Locally, the state and national contests were largely cake-walks for the incumbents. Jerry McNerney (D, CA-9) received more than 50% of the vote. Jeff Denham (R, CA-10) got more than 57% of the vote. The Assembly and State Senate members all coasted as well (though not all with as large a vote margin).
- Also, remember, no matter what they say in the media, yesterday's election was not a primary.
The Voting Wars Come to California
Rick Hasen calls this kind of thing voting wars, the extension of partisan conflict into the voting process. Last week, the California Secretary of State certified a ballot initiative for circulation (meaning its sponsors can begin to collect signatures) that would require every California polling-place voter to present a government-issued photo identification and every postal/absentee voter to include information from a government-issued identification (e.g., the last four digits of a Social Security number) in order for their vote to be counted. Never mind that the evidence for the kind voter fraud this requirement addresses is basically non-existent and that these kinds of requirements tend to discourage minorities, poor people, and the elderly from voting. Interestingly, this petition comes shortly after California enacted a new law (SB 360) that allows the state to experiment with new voting technologies (hello, internet voting!) in an effort to help more people to vote.
Here's the official synopsis:
ELECTIONS. VOTER IDENTIFICATION REQUIREMENTS. INITIATIVE STATUTE. Prohibits citizen's vote at the polls from being counted unless he or she presents government-issued photo-identification. Establishes provisional voting for citizens at the polls who fail to present government-issued photo-identification. Requires that provisional ballots and mail-in ballots be deemed invalid unless the accompanying envelope contains the citizen's birthdate, and citizen's identification number or last four digits of driver's license, state identification card, or social security number. Requires that election officials verify this information prior to opening or counting ballot. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on state and local government: Increased local government elections costs and decreased state fee revenues, potentially in the range of tens of millions of dollars per year. Potentially increased state funding (about $100 million) to local governments, offset by an equal amount of decreased state funding to local governments in future years. (13-0039.)
Be sure to look for it at a supermarket or mall near you. Then, walk away without signing the petition.
The Future of California Politics?
The California Department of Finance released its new population projections for California counties through 2060. There are a whole bunch of goodies in the report, so I thought I would highlight a few of them here.
First, by 2050, Hispanics are projected to be the plurality ethnicity in California. Here's the projected ethnic makeup (see p. 6) of California in 2010 and 2060:
By 2060, Hispanics will make up 48% of the population (up from 38%), Whites will be 30% of the population (down from 40%), Asian and Pacific Islanders will be 13% (same), African Americans will be 4% (down from 6%), and everyone else will be 5% of the population.
In terms of future voters, these changes have potentially significant implications for California politics. I am not one of the people who thinks that "demographics are destiny" in terms of party politics, at least over the long run, so I don't think these changes mean that the Republican Party is looking at long term irrelevance in California. If the party keeps its current platform, sure, but there is no reason it has to. Both parties, though, are going to have to adapt to the changing electorate as the issue sets of Hispanic voters are different than the issue sets of white voters.
Second, California will remain relatively young relative to the rest of the country. Our economy (and our budget) will not be as heavily impacted by the Baby Boomers and Generation X moving into retirement. There will still be significant demand, and resources, for public education. The aging of the population will not be uniformly distributed across ethnicities, which will also have significant implications for politics. Whites will grow older faster than any other ethnic group. By 2030, there will be more whites over the age of 65 than under the age of 25 in California. In contrast, there will by almost three times as many Hispanics under the age of 25 as there are Hispanics over the age of 65.
Third, the population–and therefore power–will continue to move inland. Southern California (particularly Los Angeles County) will remain the 800-pound gorilla in California politics, but the Central Valley (Sacramento and San Joaquin valleys) and the Inland Empire (San Bernardino and Riverside) will see their relative populations grow with the rest of the state seeing their relative populations decline. The Central Valley will see its relative population grow 27% between 2010 and 2060. The Inland Empire will see relative growth of 28%. The Bay Area, in contrast, is projected to see the steepest decline in its relative population (down 10%). These changes mean that over time the Central Valley and Inland Empire will gain representatives in Sacramento and Washington DC while other areas see their representation decine.
Fourth, San Joaquin County will more than double in size between 2010 and 2060. San Joaquin will go from being the 15th largest county in California (with just under 700,000 residents) to the 12th largest county (with over 1.5 million residents). Hispanics will account for more than half of this growth.
The Vanishing California Republican Party?
Buckle up California. The state Republican Party is flirting with complete irrelevancy this election. If the current returns hold, Democrats will control 2/3 of both the State Senate and the State Assembly, giving them complete freedom in Sacramento. The one lever that the Republican Party has held in California politics–especially after Prop. 25 (2010) lowered the threshold for passing a budget to a simple majority–is that a 2/3 vote is required to raise revenue. They may not have that lever any more.
There are 40 State Senators, and 27 votes (2/3*40=26.8) are required to pass a revenue increase. The Democrats already control 14 seats, and appear to be winning 14 more. There are no close contests here. Democrats should have the 2/3 supermajority required in the State Senate.
There are 80 Assembly members, and 54 votes (2/3*80=53.6) are required to pass a revenue increase. The Democrats appear to have won 54 seats. The two closest contests are AD-65 (Anaheim), where Sharon Quirk-Silva (D) leads Chris Norby (R) by just 1,004 votes, and AD-32 (Hanford), where Rudy Salas (D) leads Pedro Rios (R) by an even more minuscule 268 votes. Expect some lawsuits over the recount here, because right now 268 votes are all that stand between Republican relevance and Republican irrelevance.
Of course, all these numbers are provisional. That said, if the results hold after the various recounts, the Republican minority won't even need to bother to show up in Sacramento. The Democrats won't need them to do anything.
Update [11/8 at 5:00 PM]: Both Salas and Quirk Silva still lead. Salas's margin is still at 268 votes. Quirk-Silva's has gone up to 1,043 (up 39).
Update [11/13 at 11:30 AM]: Salas is now way ahead, having built a 2,500 vote lead. Given the low number of votes in the district, the difference is enough to move it off the Secretary of State's "close contest" list. Quirk-Silva's lead is now the smallest (at least in those contests where a Democrat is facing a Republican) at a little more than 2,200 votes.


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Tag Archives: event planning
Another Basic Tech Tool for Online Teachers: The World Clock
This blog is a follow-up of my 3 Basic Tech Tools for Online Teachers post. IV. How do you set the time for a worldwide event online? After all of your pedagogical considerations in planning your online session, don't let … Continue reading
Posted in TESOL Blog Tagged as event planning, online teaching, synchronous sessions, webinars, World Clock 2 Comments


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Prep Time:
Cook Time:
15 mins
48 hrs
Another of Marina's tried and true recipe. She never cooks with measurements so I've tried to measure ingredients out for you. Often I pour this over cooked rice. Yummee!
Units: US | Metric
Serving Size: 1 (692 g)
Servings Per Recipe: 4
Getting dinner on the table just got a whole lot easier.


text:
Federal workers organize to block the sequester
About 6,000 employees have filed appeals with the Merit Systems Protection Board to block furloughs or recover lost pay that is resulting from the sequester.
As Congress slips closer to a second round of across-the-board budget cuts and government furloughs this fall, federal workers have begun to fight back.
With nearly one in two federal workers facing enforced unpaid leaves of absence to help meet stringent deficit reduction mandated by sequestration, about 6,000 employees have filed appeals with the Merit Systems Protection Board to block the furloughs or recover lost pay. Meanwhile, labor unions are galvanizing public employees across the country to fight the sequester and are taking their case to Capitol Hill.
During a hearing Tuesday morning before the Senate Budget Committee, Jennifer-Cari Green, a secretary at the Madigan Army Medical Center in Washington State and the single mother of a six-year-old son, said that she had struggled to make ends meet under a three-year military pay freeze even before the sequester hit. Now she calculates that her take-home pay will drop from $1,477 a month to $1,008 through the end of September (the end of the fiscal year) as she is forced to take 11 days of furlough -- a 32% reduction over two weeks, or a 4.5% annual reduction.
"I live without luxuries, I don't have cable in my home, I don't go get my nails done, eat out frequently or do any of the things people generally think they will have to cut back on whenever times are tough," said Green, a member of Local 1502 of the American Federation of Government Employees in Tacoma. "I often hear people talk about 'tightening your belt,' but I have very few options available to me."
Instead, she said, she is falling dangerously close to the poverty line, even while she makes too much to qualify for food stamps or free school lunches for her son.
Senate Budget Committee Chairwoman Patty Murray, an ardent foe of sequestration, said that Green's dilemma is emblematic of the hardships being imposed by mindless, across the board cuts in defense and domestic discretionary spending that both Democrats and Republicans voted for believing a better budget bargain would emerge.
That bargain never happened.
"At a time when too many Americans are still struggling to find work, civilian defense employees are being furloughed, and small businesses are struggling to stay afloat, our economic recovery and our military preparedness is suffering," she said.
"While I believe there are responsible spending cuts to be made in defense programs," she added, "the current across-the-board cuts and future arbitrary spending reductions over the next eight years as part of sequestration are not the answer."
Short of a miraculous turn-around by lawmakers and the administration Congress appears to be sliding toward a second year of sequestration -- meaning the slashed budgets of the current fiscal year will soon receive an equally unpopular sequel. The same political gridlock that set off the decade-long, $1.2 trillion sequestration last fall has only worsened in recent months. House Republicans and Senate Democrats have proven incapable of agreeing to the basic contours for a fiscal 2014 budget. Nor can they work together on immigration reform, farm legislation and food stamps.
Sen. Mark Warner, D-Va., ridiculed the sequester as "stupidity on steroids" on Tuesday because it leaves most departments and agencies with little leeway to find savings without cutting into the bone of government programs or forcing temporary unpaid layoffs.
Sen. Jeff Sessions of Alabama, the ranking Republican on the Budget Committee, agreed the sequester is not the ideal way to go about cutting spending. But he insisted that "the matter that we are facing today has been made substantially worse" by the fact that President Obama prevented his defense chiefs from doing substantial advanced planning to gradually phase in the inevitable cuts."
"And I've heard from many people that the furloughs that may be necessary to some degree could have been avoided in many instances, but it was determined [by the White House] that to do the furloughs . . . was a way to politically drive the issue," Sessions said.
Obama has said repeatedly he opposes sequestration and has urged Republicans to work with him and the Democrats to find a suitable alternative approach. Obama criticized the sequester Wednesday when he kicked off a series of economic addresses at Knox College, in Galesburg, Ohio.
The president will use campaign style events to refocus attention on the economy and some of his ideas for improving the job market that have been largely ignored by Republican lawmakers.
William Galston, a budget expert with the Brookings Institution and one time policy adviser to former President Bill Clinton, said recently, "I don't see a viable majority in the two houses of Congress in favor of getting out of [the sequester] in a way that the president would accept."
Sequestration has had serious impact on some government employees and recipients of federal aid -- particularly Hispanic and black families who have seen dramatic cutbacks or outright elimination of Head Start programs for their young children.
However, there is little evidence that the reductions have undercut the economic recovery, as some predicted. In fact, the economy is expected to improve as the spending reductions mount.
Beginning July 8, about 650,000 Defense workers took the first of 11 furlough days required as part of the $85 billion in budget cuts across the board this year. The AFGE and other unions are holding workshops across the country to instruct members how to file appeals that seek to cancel the furloughs and award back pay, according to the Washington Post.
In addition to Defense Department employees, workers have filed appeals from the Internal Revenue Service, the departments of Housing and Urban Development, Homeland Security and the Interior, as well as the Equal Employment Opportunity Commission and the Environmental Protection Agency. In all, about 775,000 federal workers face furloughs of four to 15 days before the end of the fiscal year Sept. 30.
Congressional leaders and the administration could still surprise the nation and scratch out a deal before Oct. 1 that sets aside the sequester and reaches an accommodation on next year's spending levels. But any compromise would likely have to preserve more than $1 trillion worth of deficit savings over 10 years. The government can still survive on ad hoc measures that raise the debt ceiling on a short-term basis, while enabling the White House to blunt the impact of sequestration.
More from The Fiscal Times
1. Obama opposes the sequester? He signed the bill.
2. Who cares about Head Start. Its been proven ineffective.
3. Mark ex FAA is correct. Congress gets hefty pensions, gigantic salary and expense accounts, hefty health insurance (and oh by the way) is exempt from ObamaCare.
4. How about everyone start voting for Libertarian candidates, or at least Tea Party
candidates and put the fear into Dems and Rinos. Then we'll start to see some progress.
5. I'm in the same boat as other middle class workers. Coupled with pay cuts and inflation (not the phony inflation numbers the feds publish), I'm at about a 30% decrease from 4 to 5 years ago. And I'm not in a union, so you can't blame that.
With an estimated 20% of the entire federal budget going to waste, fraud, and abuse, multimillion $ vacations disguised as fact finding trips, billions doled out to our enemies, all these people are looking in the wrong direction. Another example of unions believing they should be exempt from lifes uncertainties.
The only place they need to lean on is the administration.
The number of employees in government agencies is an unstainable sham and all these agencies should have a plan in place to reduce their numbers through attrition and retirements- no new hiring.
With a 3 trillion $ budget, there is easily $600 billion/yr disappearing into the deep dark hole of government ineptitude- so much money they treat it as having no value-after all, its our money, not theirs, makes it easier to waste.
These government workers should be grateful that they have work and make that amount of money. I am a non-union worker and since January 2013 My work hours have shrunk from 33 hours to 12.and for 3 month's straight, I only got 8 hours a week. How does one survive on $86.00 dollars ? Not all of us have health benefits, great work hours as these government workers have. I don't want to sound mean or anything but They need to realize that there are so many more people in this country who are struggling to pay their bills,keep their homes and find a job.
Sorry, but 75% of these workers shouldn't be employed by a government welfare program which is what most are receiving as they don't do anything meaningful except drain the taxpayer's wallet. yEah they pay taxes too, but you know what? If I received a $100K a year for doing nothing, I would pay taxes too!
Any accountant worth his weight will tell you to look at the largest line items of any budget where to make cuts. Government labor, especially in a big Government that has run amok, is up there on taxpayer money. Time for the freeloaders to actually go out and find a real job and do some real work.
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He'Brew Bittersweet Lenny's R.I.P.A. - Shmaltz Brewing Company
Displayed for educational use only; do not reuse.
Ratings: 1,689 | Reviews: 849 | Display Reviews Only:
New York
5/5 rDev +23.2%
06-08-2012 01:32:25 | More by bspain5
3.88/5 rDev -4.4%
I need more rye beer in my life. Thankfully, Shmaltz is here to help.
Among the many numbers printed right below the label, I can see a "043/12," which I'm guessing means 'bottled on February 12, 2012;' this would put this beer as four months old at the time of this tasting.
A: Sunset red in color, gleaming in the eye with a touch of shining orange. Not much of a head forms, a smooth, soda-bubbly half-inch of crisp foam that dies down to nothing more than specks on top of the body. Light, stringy lacing.
S: Smells like tomato sauce; dear lord, the resemblance is uncanny at first. Light, sweet notes of malt must provide the fruity, acidic, earthy tastes of tomato, while the herbal rye presence provides basil and oregano undertones. Crazy. After dwelling on that mental image of pasta, there's a time to get at the guts of the nose: pumpernickel, sweet toffee, and incredibly thick caramel malts with a light sprinkling of citrus hops.
T: Fiery, smooth, delicious! At first sip, the caramel cream of the malts washes you palate clean of everything you had for lunch, breakfast, and even last night's dinner – I have malt whiplash, and I like it. I'm not normally one to dig on sweet beers, but this is just more than that. The rich darkness of toffee and rye embellishes every little detail of the grains, pulling out kilned redness, warm pumpernickel, cinnamon gum, and light chocolate. Dark fruits everywhere, too, giving date and fig center stage for a big chunk of the palate. The hops are a nice balancing agent – prickly pine and citrus zest – but are nothing compared to the sweetness of the malts. Finishes dark and creamy, with a chewy, lingering taste of bread crust and malty sugars.
M: As I said above, there's a bit of heat to this beer, but not too much; it's just enough to remind you how powerful it is. Other than that, it's full-bodied to the extreme, taking on a syrupy persona for the majority of the drink.
O: Beer with chutzpah, just like its namesake: Lenny Bruce. And at times, like Lenny, the audacity of this beer can be a little offensive – but in the end, it leaves nothing but a smile on my face.
06-07-2012 21:31:26 | More by BarryMFBurton
4.2/5 rDev +3.4%
Wow...this is a funky, interesting beer.
Picked up a 4 pack at my Round Rock Specs for about 11 bucks...total shock to see it there actually.
Poured a heavily red tinged deep copper with a thick tan head. Beautiful color on this one and a lot of thick lacing. Just gorgeous.
Getting some piney hoppiness in the scent with hints of citrus and a little alcoholic rye spice at the finish. Also a sugary dessert like quality. Strange, but good.
The flavor is quite unique. Uber-sweet malt on first sip, followed by a nice slap of piney hops and a bit of spicy rye to cut some of the malty sweetness. I'd say this is kind of like Hop Rod Rye on steroids. Lovely thick mouthfeel...certainly a slow sipper as you really want to taste all the unique qualities in this one slowly. Syrupy sweet as it warms, and quite boozy...and quite good.
Not sure about the Imp IPA status...kind of a hybrid of a barelywine/dipa, but that rye kick makes it worth a try. Give this one a shot if you like big, complex beers.
06-06-2012 02:12:59 | More by obrike
4.25/5 rDev +4.7%
06-06-2012 01:42:04 | More by JoeLacy
4.18/5 rDev +3%
Poured from a 12oz Brown bottle.
A: Good pour, deep shades of amber. copper and reds. Head was of dark white almost a copper colour, short less than a fingers width. Thick lacing.
S: Smells like an IPA, with hints of barley or pine. The rye stands out.
T: Tastes like a very good IPA topped off with a shot of creme
liquor. Small hint it alcohol
M: Good balance, bubbly.
O: A good twist on an IPA, high quality beer.
I would recommend this beer to a friend
06-05-2012 20:19:15 | More by theecaleb
4/5 rDev -1.5%
06-04-2012 17:35:07 | More by Larrydoherty
4.25/5 rDev +4.7%
06-04-2012 01:32:14 | More by HoistinBrews
4.75/5 rDev +17%
06-04-2012 00:09:47 | More by Joshgonzales79
4.5/5 rDev +10.8%
06-03-2012 23:58:21 | More by sailorastro
4.5/5 rDev +10.8%
06-03-2012 22:47:43 | More by dsuedbeck
4.25/5 rDev +4.7%
06-03-2012 14:06:32 | More by Hanzo
4.25/5 rDev +4.7%
06-02-2012 21:53:34 | More by Bran9999
4.5/5 rDev +10.8%
06-01-2012 17:47:30 | More by Hopmodium
4/5 rDev -1.5%
05-31-2012 14:16:48 | More by cdwil
South Carolina
4/5 rDev -1.5%
05-30-2012 22:12:56 | More by buckyp
4.25/5 rDev +4.7%
05-30-2012 15:39:38 | More by KevinTK
4/5 rDev -1.5%
05-30-2012 05:44:21 | More by Zaphog
4.5/5 rDev +10.8%
05-28-2012 02:18:02 | More by leodarko
4/5 rDev -1.5%
05-26-2012 03:13:19 | More by bluckbeyes
4/5 rDev -1.5%
05-23-2012 00:57:22 | More by DeezGunz14
4.5/5 rDev +10.8%
05-22-2012 13:54:55 | More by PissWarmChango
3/5 rDev -26.1%
05-19-2012 18:01:36 | More by TimH
4.16/5 rDev +2.5%
12oz bottle into wine glass
Giant off-white head, clear amber-red body with lots of rising bubbles. Smell is warm rye, alcohol, piney hops, citrus, grass. First thing I notice is a very creamy feel, then bitter oily hops. They weren't lying about using a lot of hops and malt. There's a lot of flavor here: piney hop resin, nutty/toasted malt, darker notes of clove and spice, citrus fruit, and lots of warm alcohol. Loses half a point on mouthfeel because of how abrasive the oil and alcohol is.
This is a terrific, stong, flavorful beer. Not something I'd drink all the time, but was excellent to try.
05-18-2012 03:20:48 | More by jimmah120
4.25/5 rDev +4.7%
05-16-2012 15:50:54 | More by standardcherry
3.75/5 rDev -7.6%
05-12-2012 01:10:43 | More by Lawnboy33
He'Brew Bittersweet Lenny's R.I.P.A. from Shmaltz Brewing Company
91 out of 100 based on 1,689 ratings.


text:
Congress steers government toward shutdown
Story | Sep 30, 2013 | 9:40 PM
Congress steers government toward shutdown
Story | Sep 30, 2013 | 9:40 PM
House leaders' canceled budget plan vote is a loss for Boehner
Story | Oct 15, 2013 | 4:21 PM
CPS head targets K-8 'dropout pipeline'
Story | Dec 11, 2012
Chicago Public Schools CEO Barbara Byrd-Bennett vowed Monday to move forcefully to address the city's crisis in K-8 truancy and absenteeism, declaring: "We must work to shut down the dropout pipeline." She said that "while the district has not fully...
Live-Blog: The last day of the 2011-12 legislative session.
Story | Oct 17, 2012 | 4:22 PM
Today is the final day of the 2011-12 legislative session. State lawmakers are expected to work through the night today to try to wrap up any unfinished business before they depart for an Election Season break With the cancellation of...


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Take the weather with me:
PM T-Storms
Partial cloudiness early, with scattered showers and thunderstorms in the afternoon. High 84F. Winds SSW at 5 to 10 mph. Chance of rain 50%.
Scattered T-Storms
Variably cloudy with scattered thunderstorms. Low near 65F. Winds WSW at 5 to 10 mph. Chance of rain 50%.


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Director, Technical Accounting
Position: Director Technical Accounting
The Director Technical Accounting is responsible for understanding the business to ensure the proper accounting of business transactions in accordance with US GAAP. Additionally, the Director is responsible ...
Aug 20 -
Irvine - Accounting & finance
Quality Technician IV
International Manufacturer of Medical Devices is seeking a Quality Technician IV.
Job Purpose:
·Function as a member of the Quality Assurance team to ensure patient safety and device efficacy
Key Responsibilities:
·Disposition of Nonconformities
·Certification of ...
Aug 20 -
Irvine - Biotech, R&D, & science
Quality Assurance Auditor
Manufacturing company seeks for a Lead Auditor Quality Assurance. Must have knowledge and experience with ISO 9001;2008 Quality Management Systems.
Job Summary:
Under general supervision, schedule and supervise internal audits for all facets of the company's quality ...
Aug 11 -
Costa Mesa - Everything else
Controller/Vice President Operations
Fast growing entrepreneurial company located in Huntington Beach with revenues over $250,000,000 is looking for high-energy finance executive to run and manage its finance department and related operations functions. Reporting directly to the CEO, this individual will ...
Aug 1 -
Huntington Beach - Accounting & finance
Financial Analyst
The Financial Analyst must be knowledgeable on ERP system. The analyst must be able to use MS Excel to develop and format reports to provide customer-specified information. In addition, the analyst will provide all other financial assistance required by the Project Engineer ...
Jul 29 -
Seal Beach - Accounting & finance
Chief Financial Officer
Organization: The mission of JFFS is to bring together the people, partners and resources to care for people in need, to build a vibrant community, and to sustain and enhance Jewish life. We connect and strengthen, engage and inspire, and serve people of all faiths, ...
Jul 16 -
Irvine - Everything else
Accounting Manager
Are you a CPA? Do you enjoy Accounting and Finance? I might have an opportunity for you then.
Summary: Great opportunity with a 40 plus year old, privately held company who has a global presence in the hospitality arena. Revenues are projected to exceed $375 ml in 2014. My ...
Jul 10 -
Santa Ana - Accounting & finance
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My name's Chii (just call me Fwips if you want), and i post stuff i draw. some of it is NSFW :3
I love comics, art, cute things, cooking, and cosplay. In the real world I'm your friendly neighborhood dog groomer. I write and draw the webcomic 'Iniquitous' on Smackjeeves, and attempt to be funny and make dumb jokes on the internet. Thanks for coming by~
Stuff I like
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White Stripes to Release Live Album and DVD
Also, watch a Maryland Congresswoman quote the band on the House Floor
By Tom Breihan on April 11, 2011 at 11:45 a.m. EDT
The White Stripes may be gone, but thanks to Jack White's Third Man Records, we can soon buy plenty of White Stripes music that we haven't heard before. As the Third Man website points out, the latest package available to subscribers to Third Man's Vault subscription series consists of a double-vinyl recording of the White Stripes' last-ever live show in 2007, a DVD of a live show from 2000, and a 7" single of some of their earliest recordings.
Live in Mississippi, the 180-gram vinyl double album, is a complete recording of the band's final show, which took place in Southaven, Mississippi on July 31, 2007. The sprawling tracklist includes covers of old blues greats Robert Johnson, Leadbelly, and Son House, as well as tracks from throughout their career. Speaking as someone who caught one show from that final tour, the band was in an absolutely magnificent zone onstage at the time.
The DVD is Under Moorhead Lights All Fargo Night, a recording of a show at Ralph's Corner Bar in Moorhead, Minnesota in June 2000, shortly after the release of their album De Stijl. The show includes a cover of Iggy Pop's "I'm Bored". We've got the tracklists for Live in Mississippi and Under Moorhead Lights All Fargo Night below.
The 7" single features two songs that the band recorded in 1997, before the release of their first single: covers of Love's "Signed D.C." and Otis Redding's "I've Been Loving You Too Long".
In other White Stripes news, we might be able to credit the band with helping to stop the shutdown of the federal government this past weekend. On the House Floor, Maryland Democratic Congresswoman Donna F. Edwards quoted a giant chunk of the band's song "Effect and Cause" to argue against the shutdown. And there's no way anyone was shutting the government down after that. Check out the video of Edwards quoting the band below. Thanks to Michael Buchino for the tip.
Live in Mississippi:
01 Stop Breaking Down (Robert Johnson cover)
02 Let's Build a Home
03 When I Hear My Name
04 Icky Thump
05 Dead Leaves and the Dirty Ground/As Ugly As I Seem
06 The Same Boy You've Always Known
07 Wasting My Time
08 Phonograph Blues (Robert Johnson cover)
09 Cannon/John the Revelator (Traditional)
10 Death Letter (Son House cover)
11 Astro
12 Apple Blossom
13 You Don't Know What Love Is (You Do as You're Told)
14 In the Cold, Cold Night
15 I Want to Be the Boy to Warm Your Mother's Heart
16 Hotel Yorba
17 A Martyr for My Love for You
18 Ball and Biscuit
19 300 MPH Torrential Outpour Blues
20 Blue Orchid
21 I'm Slowly Turning Into You
22 Boll Weevil
Under Moorhead Lights All Fargo Night:
01 Let's Shake Hands
02 Screwdriver
03 Wasting My Time
04 Jolene (Dolly Parton cover)
05 Little Bird
06 Apple Blossom
07 You're Pretty Good Looking (For a Girl)
08 Your Southern Can is Mine (Blind Willie McTell cover)
09 Sugar Never Tasted So Good
10 Truth Doesn't Make a Noise
11 I'm Bored (Iggy Pop cover)
12 Cannon/John the Revelator (Traditional)
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Lorde Responds to Iggy Azalea's Criticism of Nirvana Tribute: "I Had A Good Time. That's All That Matters"
June 21, 2014 at 12:40 p.m. EDT
Henry Rollins Criticizes Robin Williams in "Fuck Suicide" Essay
August 21, 2014 at 5:13 p.m. EDT
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Jack White Throws Out First Pitch at Detroit Tigers Game: Watch
By Evan Minsker on July 29, 2014 at 8:37 p.m. EDT
Articles: Wax and Wane: The Tough Realities Behind Vinyl's Comeback
While pressing plants, labels, and stores are ecstatic about the still-booming vinyl resurgence, the format's unlikely return is now leading to crippling delays and an increased reliance on questionable gimmickry.
Jack White Joins Beck for "Loser", "Where It's At", "Pay No Mind"
Sean Lennon also joins in on encore at Beck's ...
By Evan Minsker on July 27, 2014 at 2:42 p.m. EDT
Jack White To Throw Ceremonial First Pitch At Detroit Tigers Game
Plus: Third Man's Rolling Record Store headed to Comerica ...
By Zoe Camp on July 25, 2014 at 5:07 p.m. EDT
Nicki Minaj Announces Release Date For Forthcoming Album The Pink Print
It's November 28.
By Zoe Camp on August 29, 2014 at 5:48 p.m. EDT
Radiohead's Thom Yorke Does Another Surprise DJ Set: Video
At the Roosevelt Hotel in Los Angeles
By Jeremy Gordon on August 29, 2014 at 2:20 p.m. EDT
Electric Fling
Electric Fling: Lisbon's Batida Revolution
Andy Beta travels to the capital of Portugal to explore the frenetic electronic music style known as batida, which offers the city's downtrodden African-immigrant community a sound—and societal voice—of their own.
Diplo, Skrillex, and Kiesza Debut "Take U There" Live
New Jack U song live at Mad Decent Block Party
By Jenn Pelly on August 29, 2014 at 12:06 p.m. EDT