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Upcoming Events
- SIP Day (Noon Dismissal)
- School Board Meeting
Welcome to South Holland School District 150
"Where Good Things Happen for Children Everyday"
E-Pay for District/School Fees
You can now make payments for school and district fees via E-PAY by clicking here.
School District 150
Mission Statement
The purpose of South Holland School District 150 is to educate all students to their maximum potential and to maintain high standards and expectations for academic performance and behavior.
South Holland School District 150 is committed to creating a holistic, rigorous, relevant and relationship based, educational environment that produce students that will thrive and be successful learners in any local or global high school setting.
Belief Statements
- We believe the quality of instruction is contingent on employing highly qualified staff, providing ongoing staff development and providing the resources needed to successfully educate all children within the district.
- We believe that all students can learn and achieve with or without learning deficits/disabilities if provided a quality instructional program with academic support when needed.
- We believe it is our responsibility to provide an orderly, safe and secure learning environment where the teaching and learning process can occur without distractions or ongoing interruptions.
- We believe our students are capable of learning how to make good decisions regarding their schooling, health, social interactions, human relations and resolving conflict.
- We believe that ongoing staff development will provide staff the skills to deliver quality instruction and help our students to become life-long, successful learners.
- We believe in promoting continued collaboration between home, school and community to meet the needs of our students.
- To increase the percentage of students who meet and exceed the learning standards on local and state assessments.
- To expand opportunities for staff development, parental involvement and community engagement that will create a culture of continuous learning for individuals who instill and foster academic achievement and social responsibility in our students.
- To develop strategies that will help to maintain financial solvency as we meet financial obligations of the district and ensures the availability of resources needed to meet educational goals and the upkeep and improvement of our facilities.
- To integrate the use of technology to enhance the quality of learning for students and staff
South Holland School District 150 . . . Summer Reading Program
Reading is an important life-long skill that exercises our brains, improves concentration and teaches about the world around us. Reading also helps to improve vocabulary and develop the imagination.
We hope that all of our students enjoy their summer reading and projects. If you have misplaced your Summer Reading packet that was sent home with your student(s)' report cards . . . we have all the Summer Reading information posted HERE . . .
Thank you for your support. We wish you a safe and spectacular summer.
IMPORTANT: This list applies to your grade level for the 2014/2015 School Year . . .
Summer Reading Program Information ~ Greenwood Elementary (incoming PreK - Grade 3)
Summer Reading Program Information ~ McKinley Elementary (incoming Grades 4-5)
Summer Reading Program Information ~ McKinley Jr. High (incoming Grades 6-8)
IMPORTANT: This list applies to your grade level for the 2014/2015 School Year . . .
Summer Reading Program Information ~ Greenwood Elementary (incoming PreK - Grade 3)
Summer Reading Program Information ~ McKinley Elementary (incoming Grades 4-5)
Summer Reading Program Information ~ McKinley Jr. High (incoming Grades 6-8)


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Mongolia is a member of the Northeast Asian Energy Cooperation Initiative, promoted by South Korea since 2001, together with South Korea, North Korea, and Russia. The initiative brought notable cooperation in the energy sector that established Gobitech -Asian Super Grid project. At the forum, co-hosted by the intiative and the Government of Mongolia, the President of Mongolia delivered a speech at the forum about substantial resource of renewable energy in Mongolia's southern Gobi region. The Gobi Desert is estimated to be the third largest potential source of solar energy in the world and also experiences steady, strong wind speeds making it ideal for both technologies.
Yesterday, Energy Ministry of Mongolia signed a memorandum of understanding with KEPCO or Korea Electric Power Corporation, Korea's biggest power supplier and world's sixth-largest power plant builder, to start power plant project in Ulaanbaatar. Under the concession law of Mongolia, the company is expected to build and operate a fossil fuel power plant during a contract period, but it is still unclear when they will sign an official contract and when construction will begin.
In the news to Korean Times, the company's official said:
"This is a milestone making it possible for us to make inroads into the fast-growing power supply market in Mongolia," KEPCO said in a statement. "This project will make it possible for us to win other projects there."
Another Korean giant POSCO Energy, a unit of South Korea's top steelmaker POSCO, will kick off power business in Mongolia under joint consortium that comprised of GDF Suez of France, Sojitz of Japan and Mongolia's Newcom Group. In the news to South Korean News Agency Yonhap,
The consortium has signed a 1.5 trillion won (US$1.34 billion) contract to build and operate a combined heat and power plant in the suburbs of Ulaanbaatar after beating another consortium led by Samsung C&T and Korea Southern Power.
The consortium plans to start building the power plant with an annual generating capacity of 450 megawatts in 2015 and complete it by 2019, POSCO Energy said in a statement.
The consortium consists of POSCO Energy, GDF Suez of France, Sojitz of Japan and Mongolia's Newcom Group, with each of the first three companies holding a 30 percent stake in the project, while Newcom holds the rest, the South Korean company said.
After completing the power plant, the consortium will operate it for 25 years and then transfer it to the Mongolian government, the company said.
"This project will contribute to easing power shortage in Mongolia and help (POSCO Energy) expand presence in the Mongolian energy market in the future," POSCO Energy CEO Hwang Eun-yeon was quoted in the statement.
In the other news, POSCO also joined hand with MCS, one of Mongolia's largest private companies to build a clean energy project, named Baganuur Energy Corp., in the Baganuur district of Ulaanbaatar at the cost of US$2 billion.
POSCO said the joint venture plans to produce 100,000 tons of dimethyl ether and 450,000 tons of diesel oil per year. Won Kang-hee, POSCO's head of Mongolian unit, said,
"Given Mongolia's oil consumption is forecast to rise to 3.5 million tons by 2020 from last year's 800,000 tons, we are optimistic about our business prospect. Once the CTL plant is up and running, Mongolia will become a bridgehead for us to expand toward the world in the new energy resource area."


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Sin City: A Dame to Kill For
"Sin City: A Dame to Kill For" doesn't have the electricity of the original, mainly because we've already seen it. Nothing more is really revealed…
"Sin City: A Dame to Kill For" doesn't have the electricity of the original, mainly because we've already seen it. Nothing more is really revealed…
"To Be Takei" is a conventional documentary that has a surprising emotional heft. A fun, informative exploration of the life of actor, activist and Trekkie…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Roger Ebert loved superhero movies but he was a superhero himself to me.
Chaz and Roger Ebert will be awarded the Deloris Jordan Award for Excellence in Community Leadership at the 20th Annual Black Harvest Film Festival.
White privilege, lived.
An FFC Review of Kim Beyong-seo and Jo Eui-Seok's South Korean thriller "Cold Eyes."
An FFC Review of Kim Beyong-seo and Jo Eui-Seok's South Korean thriller "Cold Eyes."
An FFC looks at the horrible situation in Ferguson, MO and what it says about where we are and where we're going.
Much progress has been made in representing African-American life onscreen, but there's a long way to go.
An updated list of the theatrical venues and VOD platforms currently screening "Life Itself."
Our Far-Flung Correspondents are cinephiles from all over the world, hand-picked by Roger Ebert to write about movies from their unique international perspectives. They include contributors from (alphabetically) Brazil, Canada, Egypt, Great Britain, India, Mexico, the Philippines, South Korea, Turkey and the U.S. They converge every year at Ebertfest.
A foggy morning on the last day of the festival. One more week of movie-going, as Egypt totters and my native Midwest suffers another snowstorm, has caused both guilt and gratitude.
But before I describe what I've been experiencing in balmy Santa Barbara, an upfront mea culpa, as earlier I mangled the name of a delightful film and want to correct it here. "Good for Nothing" comes from New Zealand, a spaghetti western with a bit of "Unforgiven" tossed in. Well acted and very scenic, the story centers on an Eastwood-like lone cowboy, who says little, thinks guns are meant for killing and women for --- When he kidnaps a young English traveler, rather than dominating her as he evidently intends, she gains control, ultimately humanizing the guy and helping him unfold his hidden heart. A man at the festival suggested that, "as a woman," I wouldn't like this film at all - but he was wrong.
An excellent aspect of a film festival is the opportunity to catch those films, whether foreign (see N.Y. Times' critic A. O. Scott's outcry about the current lack of U.S. venues for foreign films) or documentaries or small budget films which aren't aimed at the mainstream audience.
"Inception," obviously an exception, is the one film I exited last year, believing director Christopher Nolan had done that story before (and better) in "Memento." For this reason, I didn't attend his SBIFF tribute but heard reports he was gracious, articulate - and much appreciated by those who did.
Instead I've watched quite a number of documentaries (perhaps a bit self-servingly, as I've worked on three myself in recent years). Two knocked me out. "Pablo's Hippos," by director Antonio Von Hildebrand, takes us to his native Colombia where the narcotics trafficking criminal Pablo Escobar was the unelected ruler, via pay-offs and mass murder, for 3 decades. Escobar, for a time Forbes' seventh richest man, had a soft spot for exotic animals, single-handedly populating a zoo (free to all who came) with zebras, giraffes, lions, tigers and hippopotamuses. When the long, strange battle to stop him ended in his death, Colombia was confronted with a species it had never had before: the hippo, the third-largest land mammal, weighing 1 1/2 to 3 tons - fast, fierce and prolific. They cost a lot to feed and house, they're dangerous and they get loose. Somehow Von Hildebrand juggles news footage, many interviews and a surprisingly effective animated sequence involving talking hippos; managing to both entertain and educate, he also warns that this narco reign of terror, now shaking Mexico, will confront Americans soon enough as well.
A second doc, "Confessions of an Eco-Terrorist," is an in-your-face account of Canadian animal rights activist Paul Watson and his 30 year campaign to stop poaching, overfishing and the slaughter of whales and baby harp seals. Watson and his Sea Shepherd Conservation Society, with its international group of volunteers (whose "vegan females" are said to be the fiercest), will go to any non-violent lengths necessary, including jamming Norwegian Naval ships, to stop the killing of sea life. Cameraman Peter Jay Brown joined the movement himself after filming a news segment for NBC. Here he unfolds one unusual story in a provocative, informative, laugh out loud funny, agitprop style.
This weekend I kept hearing the word "Darwin" spoken enthusiastically in queues. This is also a doc, not about Charles, but of an unlikely community of 35 individuals residing at the end of an unpaved road in California's Death Valley. I haven't seen it yet, but have a screener I look forward to watching, thanks to its Swiss director, Nick Brandestini, and American writer, Taylor Segrest, whom I met at an after party.
Mid-week, I took on a challenge: the red carpet --- not something I'd ever have imagined doing. Roger Ebert's pre-Oscar moments aside, this sort of entertainment reporting had so often seemed about somebody's designer of choice or the most simplistic chitchat. Pretty awful. Yet given the opportunity, I decided to try it for the premiere of "That's What I Am," an independent film about tolerance, which stars Ed Harris as a high school teacher in the 1960s.
There I was on line, with my trusty photographer, Ken Farris, at my side. As Harris and actress Amy Madigan, his wife and co-star, come up the walk, I clutch my three scribbled questions in one hand. Right ahead of me, a 7th grader in a suit starts his interview. He's cute, earnest, and does a dandy job, as a videographer shoots the moment. Harris and Madigan, both charmed, are not too fazed when he ends by asking for autographs. Upstaged, I bungle thru a couple of inanely put questions myself - as pitiful as the worst local news anchor I've ever watched - and feel relief as they move down the row toward the entrance.
I doubt I'll do that again, although I must comment that, up close, Ed Harris really does have a beautiful, chiseled face, amazing blue eyes, and obviously, with Amy, a timeless, enviable chemistry.
Peter Bart and his gorgeous wife Phyllis arrived at the Lobero Theatre Saturday afternoon. For a remarkable period, Bart has been inside the movie business, from Paramount Pictures executive to journalist and long time editor (1989-2009) of Variety. Again this year, he moderated a panel with five directors: Debra Granik ("Winter's Bone" (2010)), David O. Russell ("The Fighter"), Charles Ferguson (the one documentary: "Inside Job"), Tom Hooper ("The King's Speech"), and Darren Aronofsky ("Black Swan").
If there'd been an audience meter for most applause, Aronofsky would've taken first place. He is witty, and refreshingly modest in light of his expanding success. Hooper is politely English, perhaps a little amazed even now at the adulation for his film. And there's no David Fincher ("The Social Network") - a surprise, as often all five Oscar nominees for best director participate in this panel. I wonder if Ferguson, smart and soft-spoken, is his replacement but nobody mentions anything about it.
This year's festival is notable for its women, heartening in an industry still dominated by men. Most here are actresses, ranging from age 14 (Hailee Steinfield of "True Grit" (2010)) to 64 (Jacki Weaver of "Animal Kingdom"). Along with Lesley Manville (extraordinary in Mike Leigh's "Another Year") and actor John Hawkes ("Winter's Bone"), all are presented with Virtuoso Awards by a charmingly at ease Dave Karger of Entertainment Weekly.
And then there's Vanguard Award winner Nicole Kidman - all strawberry blonde, 5' 11" of her - appearing at the Arlington Theatre to an excited, overpacked house. The biggest movie star this year, she's dazzling, as elegant as one would expect, but also, when interviewed by SBIFF director Roger Durling, notably forthcoming, making several references, even a joke, about a certain famous ex-husband and that terrible break-up. Acknowledging her hard won happiness, she says she always needs the opposite side of life (the darkness, too), which is why she did "Rabbit Hole" (2010). As a child, exposed to avant garde theatre, and not allowed out in the sun with such fair skin, she read non-stop, developing a taste for challenge and pushing herself. She knows, if a role she's taken "frightens" her, that she's on the right track.
On the last day, I see "Face to Face," an Australian film making its world premiere here. Written and directed by Michael Rymer ("Angel Eyes"), the film is a kind of "12 Angry Men," exploring a concept called restorative justice which a schoolmate of Rymer's developed within the Australian legal system. Rather than using the courts for some disputes, this concept seems to draw on group therapy (and I mean that in the best sense), allowing all disputants voice, and enabling a full picture of an event (and its often multiple causes) to become known, before some resolution is decided. Here, one young guy seems to be the "troublemaker," but as the facts come out, many people share some blame for his violent acts. It's a very good film, reminding me both of HBO's fine series, "In Treatment," and the amazing Truth and Reconciliation Commissions of post-apartheid South Africa, Chile and beyond.
With these ten days at an end, I'm grateful for this nonstop experience of images and stories, now dancing in my head. I think how Peter Bart got it right, calling the Santa Barbara International Film Festival "an island of civility where people actually pay attention to cinema." And so, last week, did actress Annette Bening, thanking the festival and its devoted filmgoers when she said, "Our industry is under a lot of pressure. Film Festivals help it stay alive."
Amen to that.
Festival photos by Ken Farris
Next Article: "Moozlums" have been here for a long time Previous Article: Uncle Boonmee as a video installation
White privilege, lived.
This message came to me from a reader named Peter Svensland. He and a fr...
An FFC looks at the horrible situation in Ferguson, MO and what it says about where we are and where we're going.
An examination and appreciation of one of Robin Williams' greatest films, "The Fisher King."


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Innovation and Employment Growth in Industrial Clusters: Evidence from Aeronautical Firms in Germany
AbstractIn recent years we can observe a surge of interest among academics as well as regional policy makers in the phenomenon of geographical clustering of high-technology firms. In this study, we investigate whether agglomeration forces do have an impact on the innovative performance of a collection of spatially concentrated aeronautic firms in Northern Germany which is claimed to be the third largest aeronautic ?Standort?. This alleged cluster comprises a group of co-located aeronautic (supplying) firms. We analyze three forces, namely knowledge flows, demanding customers and rivalry that may have a direct impact on the innovative performance of firms. Specifically, this paper sets out to investigate three interrelated questions. 1) What agglomeration forces are relevant as measured by a significant impact on the innovative performance of firms? 2) Do firms in clusters benefit from spatially proximate inter-firm linkages, that may generate agglomerative advantages, more strongly than from distant linkages? 3) Are these forces operating exclusively in clusters, while such effects are not relevant for spatially dispersed firms? We make use of own survey data of 111 firms within and 68 outside the supposed cluster grouped around the cities of Hamburg and Bremen. A survey has been specifically designed to collect data on firms' innovation activities as well as a set of indicators for the agglomeration forces which may be operating in clusters. The latter consist of the perceived importance (6-point scale) of the various spatially inter-firm linkages that may generate agglomeration advantages. The questions are systematically asked for linkages in proximity as well as for linkages to distant firms and institutions. The basic idea underlying this concept is that it is the firms themselves that can best evaluate the relevance of such forces. The firms outside the cluster form a control group so that the effects of clustering can be identified by looking at the differences between the two groups. We have estimated a probit model of whether the firms have introduced product (process) innovations or not. The estimations provide the following results: First, for the group of cluster firms we have found that linkages to geographic proximate firms and institutions do have an impact on product innovations (process innovations are not affected). Firms that rate knowledge flows from proximate scientific institutions (e.g. universities) and proximate public information sources (e.g. trade shows) as more important are more likely to introduce product innovations. Moreover, motivational effects that stem from local rivalry have a negative effect whereas demanding customers have a positive impact on innovative performance. Second, geography seems to be relevant because only proximate firms and institutions do have a statistically significant impact. The estimated coefficients of the variables that reflect knowledge flows and motivational effects that stem from distant firms and institutions are statistically insignificant. Third, differences between the cluster and the control group exist. While demanding customers in geographical proximity do have a positive impact on innovative performance of cluster firms this effect is statistically insignificant for the firms of the control group.
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Bibliographic InfoPaper provided by European Regional Science Association in its series ERSA conference papers with number ersa03p284.
Date of creation: Aug 2003
Date of revision:
Handle: RePEc:wiw:wiwrsa:ersa03p284
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Postal: Welthandelsplatz 1, 1020 Vienna, Austria
Web page: http://www.ersa.org
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Other versions of this item:
- Werner Bonte, 2004. "Innovation and employment growth in industrial clusters: evidence from aeronautical firms in Germany," International Journal of the Economics of Business, Taylor & Francis Journals, vol. 11(3), pages 259-278.
- JEL - Labor and Demographic Economics - - - - -
- Cla - Mathematical and Quantitative Methods - - - - -
- L62 - Industrial Organization - - Industry Studies: Manufacturing - - - Automobiles; Other Transportation Equipment
This paper has been announced in the following NEP Reports:
- NEP-ALL-2004-02-29 (All new papers)
- NEP-GEO-2004-02-29 (Economic Geography)
- NEP-INO-2004-02-29 (Innovation)
ReferencesReferences listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- repec:fth:harver:1473 is not listed on IDEAS
- Fujita, Masahisa & Thisse, Jacques-Francois, 1996.
"Economics of Agglomeration,"
Journal of the Japanese and International Economies,
Elsevier, vol. 10(4), pages 339-378, December.
- Fujita,Masahisa & Thisse,Jacques-François, 2013. "Economics of Agglomeration," Cambridge Books, Cambridge University Press, number 9781107001411, April.
- Fujita,Masahisa & Thisse,Jacques-François, 2013. "Economics of Agglomeration," Cambridge Books, Cambridge University Press, number 9780521171960, April.
- Fujita, M. & Thisse, J.-F., . "Economics of agglomeration," CORE Discussion Papers RP -1250, Université catholique de Louvain, Center for Operations Research and Econometrics (CORE).
- Fujita, Masahisa & Thisse, Jacques-François, 1996. "Economics of Agglomeration," CEPR Discussion Papers 1344, C.E.P.R. Discussion Papers.
- Jaffe, Adam B & Trajtenberg, Manuel & Henderson, Rebecca, 1993.
"Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations,"
The Quarterly Journal of Economics,
MIT Press, vol. 108(3), pages 577-98, August.
- Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1992. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," NBER Working Papers 3993, National Bureau of Economic Research, Inc.
- Jaffe, A.B. & Trajtenberg, M., 1992. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," Papers 14-92, Tel Aviv.
- Catherine Beaudry, 2001. "Entry, Growth and Patenting in Industrial Clusters: A Study of the Aerospace Industry in the UK," International Journal of the Economics of Business, Taylor & Francis Journals, vol. 8(3), pages 405-436.
- Swann, Peter & Prevezer, Martha, 1996. "A comparison of the dynamics of industrial clustering in computing and biotechnology," Research Policy, Elsevier, vol. 25(7), pages 1139-1157, October.
- Oerlemans, Leon A.G. & Meeus, Marius T.H., 2002. "Spatial embeddedness and firm performance: an empirical exploration of the effects of proximity on innovative and economic performance," ERSA conference papers ersa02p054, European Regional Science Association.
- Zvi Griliches, 1998.
"Patent Statistics as Economic Indicators: A Survey,"
NBER Chapters,
in: R&D and Productivity: The Econometric Evidence, pages 287-343
National Bureau of Economic Research, Inc.
- Griliches, Zvi, 1990. "Patent Statistics as Economic Indicators: A Survey," Journal of Economic Literature, American Economic Association, vol. 28(4), pages 1661-1707, December.
- Zvi Griliches, 1990. "Patent Statistics as Economic Indicators: A Survey," NBER Working Papers 3301, National Bureau of Economic Research, Inc.
- Baptista, Rui & Swann, Peter, 1998. "Do firms in clusters innovate more?," Research Policy, Elsevier, vol. 27(5), pages 525-540, September.
CitationsCitations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
Cited by:
- Thomas Brenner & André Mühlig, 2007. "Factors and Mechanisms Causing the Emergence of Local Industrial Clusters - A Meta-Study of 159 Cases," Papers on Economics and Evolution 2007-23, Philipps University Marburg, Department of Geography.
- Mercedes Delgado & Michael E. Porter & Scott Stern, 2012. "Clusters, Convergence, and Economic Performance," NBER Working Papers 18250, National Bureau of Economic Research, Inc.
- Richard Harris, 2011.
"Models Of Regional Growth: Past, Present And Future,"
Journal of Economic Surveys,
Wiley Blackwell, vol. 25(5), pages 913-951, December.
- Richard Harris, 2008. "Models of Regional Growth: Past, Present and Future," SERC Discussion Papers 0002, Spatial Economics Research Centre, LSE.
- Fu, Xiaolan & Pietrobelli, Carlo & Soete, Luc, 2011. "The Role of Foreign Technology and Indigenous Innovation in the Emerging Economies: Technological Change and Catching-up," World Development, Elsevier, vol. 39(7), pages 1204-1212, July.
- David Smith & Gamal Ibrahim, 2006. "Cluster Dynamics: Corporate Strategy, Industry Evolution and Technology Trajectories -- A Case Study of the East Midlands Aerospace Cluster," Local Economy, Taylor and Francis Journals, vol. 21(4), pages 362-377, November.
- Doran, Justin & Jordan, Declan, 2012. "Cross Sectoral Differences in Drivers of Innovation," MPRA Paper 44470, University Library of Munich, Germany.
- Thomas Brenner & Andreas Gildner, 2006. "Long-term Implications of Local Industrial Clusters," Papers on Economics and Evolution 2006-08, Philipps University Marburg, Department of Geography.
- Richard Harris, 2008. "Models of regional growth: past, present and future," LSE Research Online Documents on Economics 33146, London School of Economics and Political Science, LSE Library.
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Henry Melton was arrested last December after a late-night altercation at a Texas bar. Now, video has surfaced of the night in questions, and Henry Melton is being sued for biting the bar owner.
We've got a running list of all your Chicago Bears signings, rumors, news, and a handy free agent tracker to boot. Join us below for live discussion and instant analysis!
General manager Phil Emery continues to be active in Free Agency, this time adding a return specialist to the roster.
The Chicago Bears added another defensive end on Thursday, which means they likely have their two starters come opening day.
The Chicago Bears held a press conference early this afternoon to introduce the newest members of the team, defensive end Lamarr Houston and safety Ryan Mundy. Here's a recap with some help from...
McCown is the first former Bear to join Lovie Smith and the Buccaneers, but won't likely be the last.
The Chicago Bears added to their defense on day two of free agency by plucking a 16 game starter from the Green Bay Packers.
Chris Williams didn't work out with Chicago, but he has resurrected his career in the last couple seasons. On Wednesday, he signed a four-year deal with Buffalo.
It's day #2 of the 2014 league year... what does Phil Emery have in store for Chicago?
The Bears part way with veteran defensive end Julius Peppers, eating a lot of dead money and freeing up even more cap space.
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Berman, Jeanette and Smyth, Robyn (2013) Conceptual frameworks in the doctoral research process: a pedagogical model. Innovations in Education and Teaching International . pp. 1-12. ISSN 1470-3297 (In Press)
Austin, Jon and Williams-Mozley, John (2012) An alternative view of mixed methods research: learning with and from indigenous ways of knowing. In: 5th Biennial InternatIonal Indigenous Development Research Conference (NPM 2012): Indigenous Transformation through Research Excellence, 27-30 Jun 2012, Auckland, New Zealand.
Goodall, Peter (2012) Human values in a mass society: a reading of George Orwell's novels. In: What is the human? Australian voices from the humanities. Australian Scholarly Publishing, Melbourne, Australia, pp. 139-153. ISBN 978-1-921875-60-1
Whitty, Stephen Jonathan (2011) On a new philosophy of project management: an investigation into the prevalence of modern project management by means of an evolutionary framework. International Journal of Managing Projects in Business, 4 (3). pp. 524-533. ISSN 1753-8378
Austin, Jon and Hickey, Andrew (2007) Autoethnography and teacher development. International Journal of Interdisciplinary Social Sciences, 2 (2). pp. 369-378. ISSN 1833-1882


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Love the taste of Chinese but want cheese too? I'm not sure where this recipe came from, but it's a great blending of two cultures and very kid-friendly. My family loves it!
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Cherry Tomato
Korean Drama Cherry TomatoPark Gu makes a living for himself and his granddaughter Da-seong by collecting recyclable paper on the street. Their situation becomes worse when his son is released from prison and steals Park's savings, and his bicycle-drawn cart ? his only tool for making money ? is destroyed by construction workers. Park visits the house of the construction company's head, where he ends up trying to steal meat for his hungry granddaughter. But the meat, which was for the owner's dog, had been poisoned by the housekeeper, who doesn't like her boss.Year: 2008Cast: Byeong-chun Kim, Hyang-ki Kim, Goo Shin ..., Ji-yeon Choi, Dong-gyoon Choi, Choi Ji Yeon, Kim Hyang-ki, Sin GooLink to this page: BookmarkFavouriteSubmit link
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Stan Collymore who was congratulated by Match Of the Day host Gary Lineker told by the BBC he will not be appearing on MOD2 in the foreseeable future
Lenny Henry tells Roz Laws why he's now tired of telling jokes and yearns to tell a compelling story
The overall turnout in the hastily arranged summer by-election was down on the 12 per cent who voted in the November 2012
Britain's first ever Police and Crime Commissioner by-election takes place in the West Midlands on August 21. Here, the four candidates say why you should vote for them.
Tory hopeful for new police and crime commissioner role says spending needs to be better controlled at West Midlands Police
Dudley councillor tells conference in Birmingham that Nazi leader was a magnetic and forceful performer
Judge dismissed former Liberal Democrat councillor's witness intimidation claims over 2008 poll at election court hearing
Victory in Birchills-Leamore gives the party 30 out of 60 council seats which could be enough to depose ruling Tory-Lib Dem administration
She claims police have not questioned her during lengthy investigation
Solihull politician will appear before magistrates in Birmingham to face allegations over travel expenses
Move is blow for Birmingham councillor Yvonne Mosquito who stepped into role following death of Bob Jones
The political and policing world is still reeling from the sudden and unexpected death of the 59-year-old Labour commissioner on July 1
Political leaders across the region had hoped to postpone the by-election campaign to choose the his successor at least until after his funeral.
Lichfield MP apologises over comments made about Yasmin Alibhai-Brown after watching TV debate on Trojan Horse and British values
Dudley North Labourt MP Ian Austin tells Commons there should be a referendum on leaving the EU before the next election
Our political editor Jonathan Walker on the big issues that are hitting the news.
Former editor of Birmingham City's Zulu fanzine was accused of posting racist and homophobic comments online
Labour MP Roger Godsiff calling for immigration action in open letter to party leader Ed Miliband
Liberal Democrat candidate Waheed Rafiq claims he and his team witnessed the alleged incidents first hand at nearly all 23 polling stations
QPR's Joey Barton and Monster star Charlize Theron both put their foot in it this week.
Dave Small spent 14 years editing the Zulu magazine - named after the notorious firm of Birmingham City hooligans
It was reported at the weekend that, in February 2013, Mr Small referred to gay people as "perverts" and expressed opposition to "poofs and dykes" being allowed to marry
David Small has been told to stand down by his party while they investigate claims he referred to gay people as 'perverts', African immigrants as 'scroungers'
Party leader Nigel Farage described the vote as a 'political earthquake' as UKIP pushed Labour and the Conservatives into second and third place, while the Lib Dems were all but wiped out.
Mike Lockley, Midlands Columnist of The Year, gets to grips with life in the big city.
Yet the 92 year-old Duke of Edinburgh drops clangers almost as often as Benefit Street's White Dee parties in Magaluf.
UKIP's biggest local election success in the region came in Dudley, where it gained seven seats - making it the only party to make gains in the Labour-run borough
Authority's Labour group leader David Jamieson loses to UKIP's Debbie Evans in major upset
Neil Elkes reports on the results of the council elections
Comedian tells of race hate attack on couple and fears that prejudice continues
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I have stayed at this Hotel on several occasions , as part of overall Tour arrangements. Rooms are generally clean and pleasant ( can be a little hot and stuffy ). Hotel facilities are reasonable and the service can be variable. Buffet Breakfasts are generally good and Evening Meals ( A La Carte ) are tasty and well-presented. The Hotel... More
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Podere Alberto
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Travel Blogs from Montepulciano
Bolsena - It's just like going home!
... again!! I need to find a dentist to address the issue and we speculated that Siena was probably our best bet to find the services required,... so it was back to Siena and a google search to find 'the man'. Monday morning we found him, but,.. he wasn't available till Friday (off at a conference),.. So, a quick rethink of the itinerary and we headed off to the coast for a few days. We chose Castiglioncello, as our destination,.. some 90 Klms from Siena and just south of Livorno. ...
A Taste of Tuscany
... pan fried rabbit with olives and roasted potatoes. Dolci was a torte. She paired each course with a different wine from this area. We learned new recipes and techniques that we, (mostly Tom) will be able to make again when we return home.
After our siesta, we walked up the hill from where we are staying into Montalcino. It's a quaint little town with amazing views. Looking forward to exploring more of Tuscany tomorrow.
Italian Birthday Adventures
... with lots of outdoor restaurants in several busy Piazzas. We also drove to Le Celle of St. Francis. It was a monastery built about 1211 by St. Francis and his followers as a place to come and pray. The "cells" were big enough for a bed, table and chair. Currently there are 7 Friars who live there and practice the teachings of St. Francis. It was a beautiful place just to walk through the forest and enjoy nature. When we arrived at our bed and breakfast, the woman knew ...
Breakfast in Montepulciano
Kevin got up early to go to the laundermat so we could do a little laundry. Thanks Kevin!! Had breakfast at the Trattoria owned by the same people as the hotel. It was a buffet with lots of choices. After breakfast we did a little shopping and then checked out. Off to ...
Orvieto underground
... of information. The tombs were created out of carved tufa blocks, and engraved with the name of the deceased.
Under the city is a labyrinth of caves and tunnels. Each house/building had its own "cellar", the usage depending on aspect and need. The cellar was dug to provide building material for the house above, and also to increase the available space. Some cellars had been complete workshops. On the warmer southern side of ...
TripAdvisor Reviews Podere Alberto Montepulciano
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- A room with a view
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- Loved Sant Antonio
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2 critically injured in explosion, fire at Carbon County natural gas plant
Ben Tidswell, Deseret News
PRICE — Two men were critically injured in an explosion and fire Tuesday at the Dry Canyon natural gas operations station.
Doug Jenkins was listed in critical condition at University Hospital's Intermountain Burn Center in Salt Lake City, according to a hospital spokeswoman. The name of the other man was not immediately available, but officials from the Carbon County Sheriff's Office said he is also listed in critical condition at the hospital.
"They have burns … from their ankles up to about the back of their heads, on their backs, from actually trying to evacuate the area when that explosion happened," said Carbon County Sheriff's Lt. Troy Christiansen.
Emergency crews were called about 10 a.m. The lack cellphone communication in the area caused a delay of more than an hour before a 911 call could be made, Christiansen said. In fact, a passerby picked up the victims and drove them to meet an ambulance.
The men were flown by medical helicopter to the hospital, said Jim Felton of the Bill Barrett Corp., an oil and natural gas exploration and development company that operates the station in the Nine Mile Canyon area, about 20 miles east of Price.
From the air Tuesday afternoon, KSL's Chopper 5 captured scenes from the catastrophic explosion: smoke filling the air and flames continuing to burn.
The damage to the facility itself was stunning: a giant creator in the ground, buildings obliterated by the blast, and charred shells of what used to be pickup trucks.
"The amount of damage there, I can't give you monetary value, but it's pretty expensive," Christiansen said. "It looks like a total loss. As far as the compression station, they'll have to rebuild it."
Firefighters throughout Carbon County were dispatched to the scene. Once they arrived, they kept their distance, allowing the facility to burn as a precaution. With a large amount of natural gas on site in tanks, emergency officials decided it was better to let it burn off.
"We're just evacuating to make sure no firefighters are injured just because of the property loss," Christiansen said. "We'd rather just let it burn out than get more people injured."
The Carbon County fire marshal was on scene, and Occupational Safety and Health Administration representatives are expected to arrive Wednesday to assess the situation.
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Habikino, Japan
ARLINGTON — How big a deal is Yu Darvish?
The Texas Rangers' Japanese pitching sensation now has his hometown and the city he plays in building a bond.
The mayor of Habikino, Japan sent Arlington Mayor Robert Cluck a special package this week.
Inside was a photo of the Japanese symbol for friendship; a photo of Mayor Tsuguo Kitagawa; and a kimono with both cities' names on the front.
"I wrote him a letter and sent him gifts — mainly Rangers gear — and said I want to be friends," Cluck said.
The Arlington mayor reached out to Darvish's hometown after the pitcher was signed by the Rangers earlier this year. He is looking to create a sister-city relationship with the Japanese town near Osaka that has about one-third the population of Arlington.
Cluck has invited Mayor Kitagawa to join him for a game at the Ballpark in Arlington. It's an offer Kitagawa said he looks forward to.
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4. Pressure the quarterback – We've talked about trying to protect Sam Bradford, but on the flip-side the Rams really need to get after whoever plays under center for Arizona. Kevin Kolb is questionable and will likely be a game-time decision according to reports, but whether it's Kolb or John Skelton back there, the defense has to get pressure. If Kolb plays, he will still be slowed by his toe/foot injury, and if Skelton plays we know he can be pressured.
5. Execute in the red zone – This one might be a long shot since the Rams haven't really executed in the red zone for the last two seasons, but if they get opportunities they have to take advantage. The game will likely be low-scoring like last time, so anytime we have a chance to get six, we have to do so. This team isn't nearly good enough to squander opportunities.
Tags: Arizona Cardinals Calais Campbell John Skelton Kevin Kolb NFC West Patrick Peterson Red Zone Sam Bradford SJ39 St. Louis Rams Steven Jackson


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Rock Stars vs. Rap Stars
Sidestepping the authorities may be something rap and rock has in common, but what happens when the authorities are us? Josh Homme, frontman for Queens of the Stone Age, got upset by Jay Z's tight security measures for his 2013 Made in America Festival and refused to perform if his band got a bag check. "That guy's a kook," Homme said in an interview later. "He has his security frisking the bands on the way in. No one's ever done that. You shouldn't frisk my guys, you should f--k off."
By the end, however, it worked out and the band did perform. This is far from the first time Jay's clashed with rockers. Click on to see other examples of when rappers and rockers engage in some cross-genre beef.
(Photos from left: Brian Ach/Getty Images,Theo Wargo/Getty Images)
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Buca di Beppo Waldorf serves authentic Italian cuisine in an eclectic, vintage setting. Our dishes are se... more
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The starter chips and salsa are addictive. Seating and light is very adequate. Interior design and decor ... more
Boston Market offers convenient great-tasting home-style meals you can feel good about eating and serving... more
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any one here already played this game? i need a guild for upcoming OBT any one ? ^^
I have no idea what you're talking about.
He's talking about Eclipse War. Hence their signature image.
The right man, in the wrong place... can make all the difference in the world.
Playing MMO: FFXIV (Ragnarok)
Waiting On: EverQuest Next · Saving For: An Epic Computer


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Download the Free Unbound MEDLINE PubMed App to your smartphone or tablet.
Available for iPhone, iPad, iPod touch, and Android.
Molecular pharmaceutics [journal]
2254 results
- Folate receptor-β in activated macrophages: Ligand binding and receptor recycling kinetics. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 28.
Activated macrophages overexpress a receptor for the vitamin folic acid termed the folate receptor β (FR-β). Because conjugation of folate to low molecular weight drugs, genes, liposomes, nanoparticles, and imaging agents has minor effects on FR binding, the vitamin can be exploited to target both therapeutic and imaging agents to activated macrophages without promoting their uptake by other healthy cells. In this paper we characterize the binding, internalization and recycling kinetics of FR-β on activated macrophages in inflamed tissues of rats with adjuvant-induced arthritis. Our results demonstrate that saturation of macrophage FR is achieved at injection doses of ~150-300 nmol/kg, with more rapidly perfused tissues saturating at lower doses than inflamed appendages. After binding, FR-β internalizes and recycles back to the cell surface every ~10-20 minutes, providing empty receptors for additional folate conjugate uptake. Because the half-life of low molecular weight folate conjugates in the vasculature is usually <1 hour, these data suggest that targeting of folate conjugates to activated macrophages in vivo can be maximized by frequent dosing at conjugate concentrations that barely saturate FR (~150 nmol/kg), thereby minimizing nonspecific binding to receptor-negative tissues and maximizing the probability that unoccupied cell surface receptors will be exposed to folate-drug conjugate.
- Effect of Surface Functionality of Silica Nanoparticles on Cellular Uptake and Cytotoxicity. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 28.
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2 which is hydrophilic and positively charged) and methyl functionalized MCM-41 (MCM-41-CH3 which is hydrophobic and negatively charged) and evaluated for in vitro release and cell cytotoxicity in human squamous cell carcinoma cell line (SCC25). Various techniques were employed to evaluate the performance of these materials on cellular uptake and anticancer activity in SCC25 cell line. Both positively and negatively charged surface demonstrated enhanced drug release and anticancer activity compared to pure curcumin. Positively charged nanoparticles showed higher cell uptake compared to negatively charged nanoparticles owing to its electrostatic interaction with cells. However, hydrophobic surface modified nanoparticles (MCM-41-CH3) showed no improvement in drug release and anticancer activity due to its poor wetting effect. Cell cycle analysis and cell apoptosis studies revealed different pathway mechanisms followed by the positively and negatively charged nanoparticles but exhibiting similar anticancer activity in SCC25 cells.
- On the Barrier Properties of the Cornea: A Microscopy Study of the Penetration of Fluorescently Labeled Nanoparticles, Polymers, and Sodium Fluorescein. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 28.
Overcoming the natural defensive barrier functions of the eye remains one of the greatest challenges of ocular drug delivery. Cornea is a chemical and mechanical barrier preventing the passage of any foreign bodies including drugs into the eye, but the factors limiting penetration of permeants and nanoparticulate drug delivery systems through the cornea are still not fully understood. In this study, we investigate these barrier properties of the cornea using thiolated and PEGylated (750 and 5000 Da) nanoparticles, sodium fluorescein, and two linear polymers (dextran and polyethylene glycol). Experiments used intact bovine cornea in addition to bovine cornea de-epithelialized or tissues pretreated with cyclodextrin. It was shown that corneal epithelium is the major barrier for permeation; pretreatment of the cornea with β-cyclodextrin provides higher permeation of low molecular weight compounds, such as sodium fluorescein, but does not enhance penetration of nanoparticles and larger molecules. Studying penetration of thiolated and PEGylated (750 and 5000 Da) nanoparticles into the de-epithelialized ocular tissue revealed that interactions between corneal surface and thiol groups of nanoparticles were more significant determinants of penetration than particle size (for the sizes used here). PEGylation with polyethylene glycol of a higher molecular weight (5000 Da) allows penetration of nanoparticles into the stroma, which proceeds gradually, after an initial 1 h lag phase.
- Successful Entrapping of Liposomes in Glucan Particles: an innovative micron-sized carrier to deliver water soluble molecules. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 27.
Glucan particles (GPs) are monodisperse microspheres derived from baker's yeast, and represent an interesting class of microcarriers for theranostic applications as they show a high affinity towards immune system cells. The typical loading strategy was to harness the ability of the molecule to be loaded to interact with nano- micro-assembled systems through electrostatic or hydrophobic forces. However, small water soluble chemicals could not be steadily retained by the leaky shell of GPs. In this work, we propose an alternative loading approach for small water soluble compounds that is based on their entrapment in the aqueous core of liposomes that are directly formed into the microparticles through the reverse phase evaporation method (REV). The construct obtained may act as biocompatible carrier to deliver and release, even in triggerable way, bioactive compounds.
- Comparison of Binding Characteristics and In Vitro Activities of Three Inhibitors of Vascular Endothelial Growth Factor A. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 27.
The objectives of this study were to evaluate the relative binding and potencies of three inhibitors of vascular endothelial growth factor A (VEGF), used to treat neovascular age-related macular degeneration, and assess their relevance in the context of clinical outcome. Ranibizumab is a 48 kDa antigen binding fragment, which lacks a fragment crystallizable (Fc) region and is rapidly cleared from the systemic circulation. Aflibercept, a 110 kDa fusion protein and bevacizumab, a 150 kDa monoclonal antibody, each contain an Fc region. Binding affinities were determined using Biacore analysis. Competitive binding by sedimentation velocity analytical ultracentrifugation (SV-AUC) was used to support the binding affinities determined by Biacore of ranibizumab and aflibercept to VEGF. A bovine retinal microvascular endothelial cell (BREC) proliferation assay was used to measure potency. Biacore measurements were format dependent, especially for aflibercept, suggesting that biologically relevant, true affinities of recombinant VEGF (rhVEGF) and its inhibitors are yet to be determined. Despite this assay format dependency, ranibizumab appeared to be a very tight VEGF binder in all three formats. The results are also very comparable to those reported previously1-3. At equivalent molar ratios ranibizumab was able to displace aflibercept from preformed aflibercept-VEGF complexes in solution as assessed by SV-AUC, whereas aflibercept was not able to significantly displace ranibizumab from preformed ranibizumab-VEGF complexes. Ranibizumab, aflibercept, and bevacizumab showed dose-dependent inhibition of BREC proliferation induced by 6 ng/ml VEGF, with average IC50 values of 0.088 ± 0.032 nM, 0.090 ± 0.009 nM, and 0.500 ± 0.091 nM, respectively. Similar results were obtained with 3ng/mL VEGF. In summary Biacore studies and SV-AUC solution studies show that aflibercept does not bind with higher affinity than ranibizumab to VEGF as recently reported 4 and both inhibitors appeared to be equipotent with respect to their ability to inhibit VEGF function. 1. Ferrara, N.; Damico, L.; Shams, N.; Lowman, H.; Kim, R. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 2006, 26, (8), 859-70. 2. Lowe, J.; Araujo, J.; Yang, J.; Reich, M.; Oldendorp, A.; Shiu, V.; Quarmby, V.; Lowman, H.; Lien, S.; Gaudreault, J.; Maia, M. Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo. Exp Eye Res 2007, 85, (4), 425-30. 3. Presta, L. G.; Chen, H.; O'Connor, S. J.; Chisholm, V.; Meng, Y. G.; Krummen, L.; Winkler, M.; Ferrara, N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997, 57, (20), 4593-9. 4.Papadopoulos, N.; Martin, J.; Ruan, Q.; Rafique, A.; Rosconi, M. P.; Shi, E.; Pyles, E. A.; Yancopoulos, G. D.; Stahl, N.; Wiegand, S. J. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 2012, 15, (2), 171-85.
- One-Pot-Multi-Tracer Synthesis of Novel 18F-Labelled PET Imaging Agents. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 26.
- AbstractPublisher Full Text
18F labelled phosphonium salts are increasingly important molecular probes for targeting the mitochondrial membrane potential depletion during apoptosis and for detecting myocardial perfusion deficit. Here, we introduce two new tracers, [18F]MitoPhos_04 and [18F]MitoPhos_07, that can act as mitochondrial imaging agents and have the added advantage of being synthesised in the same reaction vial from one radiolabelled synthon. The radiosynthesis of both tracers was carried out on a fully automated system via a facile two-step reaction. Utilising the radiolabelling of an ethyl azide, a copper-mediated 1,3-cycloaddition reaction and isolation via semi-prep HPLC allowed for the simultaneous synthesis of two tracers with a total synthesis time of less than 1 hour. Initial cellular uptake studies demonstrated that the uptake of [18F]MitoPhos_04 was substantially higher than that seen for [18F]MitoPhos_07 in the murine -lymphoma cell line, 38C13.
- PET imaging of neovascularization with 68Ga-3PRGD2 for assessing tumor early response to Endostar anti-angiogenic therapy. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 26.
Objectives: Anti-angiogenic therapy is an effective strategy to inhibit tumor growth. In this study, 68Ga-3PRGD2 targeting integrin αvβ3 was evaluated to be a PET tracer for monitoring the efficacy of Endostar anti-angiogenic therapy in an animal model. Methods: Thirty-two LLC tumor bearing mice were randomly divided into two groups. The mice in treatment group were administrated with Endostar (8 mg/kg/day) via tail vein injection for three weeks, while the mice in control group were administrated with saline. The 68Ga-3PRGD2 PET imaging was performed at 3, 7, 14 and 21 d post-treatment, while using 18F-FDG PET imaging as the control. Immunofluorescence staining and Western blot were carried out to validate the imaging results. Results: Endostar inhibited the newborn vascular endothelial cells, causing the decrease of integrin αvβ3 expression, which led to the decrease of 68Ga-3PRGD2 uptake in tumor. This finding was confirmed by immunofluorescence staining and Western blot results. As compared with control group, 18F-FDG imaging showed the uptake difference on 14 d post-treatment, whereas 68Ga-3PRGD2 imaging showed the uptake difference on 3 d post-treatment. Conclusions: As a specific probe, 68Ga-3PRGD2 targeting integrin αvβ3 can be used to monitor the efficacy of anti-angiogenic therapy. Compared with 18F-FDG metabolic imaging, 68Ga-3PRGD2 PET reflects the tumor response to anti-angiogenic therapy much earlier and more accurately, which provides new opportunities to develop individualized therapeutic approaches, establish optimized dosages and dose intervals for effective treatment that improve the survival rate of patients.
- Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 26.
- AbstractPublisher Full Text
Intestinal transporters are crucial determinants in the oral absorption of drugs. We therefore studied mRNA expression (N=33) and absolute protein content (N=10) of clinically relevant transporters in healthy epithelium of the duodenum, proximal and distal jejunum and ileum and the ascending, transversal, descending and sigmoidal colon of six organ donors (24-54 years). In the small intestine, the abundance of nearly all studied proteins ranged between 0.2-1.6 pmol/mg with the exception of OCT3 (<0.1 pmol/mg) and PEPT1 (2.6-4.9 pmol/mg) which accounted for ~50% of all measured transporters. OATP1A2 was not detected in any intestinal segment. ABCB1, ABCG2, PEPT1 and ASBT were significantly higher abundant in jejunum/ileum than in colon. In contrast to this, ABCC2, ABCC3 and OCT3 expression was found to be highest in colon. Site-dependent expression was confirmed for ABCB1 and ASBT and significant correlations between mRNA and protein levels for ABCG2, ASBT, OCT3 and PEPT1 in the small intestine. Our data provide further physiological pieces in the puzzle required to predict intestinal drug absorption in man.
- Prodrugs of Pioglitazone for Extended-Release (XR) Injectable Formulations. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 26.
- AbstractPublisher Full Text
N-acyloxymethyl derivatives of pioglitazone (PIO) have been prepared and characterized as model candidates for extended-release injectable formulations. All PIO derivatives prepared are crystalline solids as determined by powder X-ray diffraction, and the solubility in aqueous media is below 1 μM at 37 °C. The melting points steadily increase from 55 oC, for the hexanoyloxymethyl derivative, to 85 °C, for the palmitoyloxymethyl derivative; inversely, the solubilities in ethyl oleate decrease as a function of increasing acyl chain length. The butyroyloxymethyl ester has a higher melting point and a lower solubility in ethyl oleate than expected from the trend. The 13C solid-state NMR spectra of the PIO homologs between the hexanoyloxymethyl derivative and stearoyloxymethyl derivative suggest a common structural motif with the acyl chains exchanging between two distinct conformations, and the rate of exchange is slower for longer chain derivatives. The butyroyloxymethyl derivative is efficiently converted to PIO in in vitro rat plasma with a half-life of < 2 minutes at 37 ° C, while the rate of enzymatic cleavage in rat plasma decreases as the ester chain length increases for the longer acyloxymethyl derivatives. The concentration of PIO in plasma increases rapidly, or "spikes," in the hours following intramuscular (IM) injection of either the HCl salt or the butyroyloxymethyl derivative. In contrast, the more lipophilic palmitoyloxymethyl derivative provides slow growth in the PIO concentration over the first day to reach levels that remain steady for two weeks. Based on its in vivo pharmacokinetic profile, as well as material and solubility properties, the PIO palmitoyloxymethyl derivative has potential as a once-monthly injectable medication to treat diabetes.
- Bacterial cellulose/acrylamide pH-sensitive smart hydrogel: Development, characterization and toxicity studies in ICR mice model. [JOURNAL ARTICLE]
- Mol Pharm 2014 Aug 26.
- AbstractPublisher Full Text
The objective of this study is to synthesize and evaluate acute toxicity of the bacterial cellulose (BC)/acrylamide (Am) hydrogels as non-cytotoxic and biocompatible oral drug delivery vehicles. A novel series of solubilized BC/Am hydrogels were synthesized using a microwave irradiation method. The hydrogels were characterized by Fourier transform infrared (FTIR), swelling ratio, porosity, drug release, in vitro and in vivo biocompatibility experiments. FTIR spectra revealed that the BC crystallinity and gel fraction decreased as the NaOH concentration increased from 2% to 10% w/v, whereas the optical transparency, pH sensitivity, and porosity were enhanced with increasing alkali concentration. Theophylline was used as a model drug for drug loading and release studies. The percentage of drug released was higher at pH 7.4 compared to pH 1.5. In vitro cytotoxicity and hemolytic tests indicated that the BC/Am hydrogel is non-cytotoxic and hemocompatible. Results of acute oral toxicity tests on ICR mice suggested that the hydrogels are non-toxic up to 2000 mg/kg when administered orally, as no toxic response or histopathological changes were observed in comparison to control mice. The results of this study demonstrated that the pH-sensitive smart hydrogel makes it a possible safe carrier for oral drug delivery.


text: Neika Boo's Knockout Crew!! First time here? Use the CustomInk design lab to make your own t-shirts! Is it a winner? Current Score4.3 View full-size image Design Your Own < previous next > "TaNeika was diagnosed with stage 2 grade 2 breast cancer at the young age of 28 just two-years after losing her mother to this horrible disease. We have ordered these shirts to help support her on the days she receives chemotherapy. With her family all living in Evansville and not able to be here with her through it all her friends and work family have stepped up to the plate to show their love and support for her on a daily basis. CustomInk has been absolutely amazing throughout this whole process of designing, ordering, and receiving our shirts. Which we LOVE!!" - Fight Like A Guurl (May 30, 2013) Similar Photos: breast cancer | fighter | friends | Knockout Crew | charity | coworkers | participant teams | pink | support Share this photo: Twitter Facebook comment by Guest - May 31, 2013 - back to the top Fight girl fight..... This Sierra momma... Luv yu comment by Guest - May 31, 2013 - back to the top Shes got this ..!!! XOXOX LUV U ! BOBBIE -BOO comment by Guest - Jun 07, 2013 - back to the top YOU GOT THIS GUURL! KEEP YOUR HEAD UP AND STAY STRONG! DIDO NIECER


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Over the past decade, the controversy of family presence during cardiopulmonary resuscitation (CPR) and invasive procedures has increased. Many professional organizations have supported the notion of family presence and have developed position statements concerning this topic.l Yet the controversy continues, mainly due to lack of policy changes and adaptation of written policies into practice.
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WEEKEND BEST BEST: Craft Beer and Cigar Box Guitar Festival
Date: November 2, 2012
by: Nick Friedman | Community Editor
Put on your best smoking jacket and clear your palate for a sampling of your favorite craft beers and cigars this Saturday as part of the Craft Beer and Cigar Box Guitar Festival.
Cigar City Brewing present this festival, which features performances by four cigar box guitarists, including Ben Prestage, The Cotton Pickin' Blues Brothers Band and The Al Fuller Cigar Box Trio. Craft beers will be available on tap. Cost is $10. Call 366-3010.
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- Aug
23 Casting Auditions-Sarasota Medieval Fair
9:00 am - 3:00 pm
- Aug
23 French open house with coffee and croissants
10:00 am - 12:00 pm
- Aug
23 Casting Auditions-Sarasota Medieval Fair
11:00 am - 3:00 pm
- Aug
23 Sunset Dinner Cruise with the Sarasota Singles Society
6:00 pm - 9:00 pm
Tw-Ice as Nice
Bob's Boathouse hosted an ALS Ice Bucket Challenge and fundraiser event Tuesday.
Mazel tov to Klauber and Mancini
The West Coast Florida Region of AJC (American Jewish Committee) will honor Michael Klauber and Phil Mancini, of Michael's On East, with its Civic Achievement Award in November.
Every dog has its day
Consulate Health Care of Sarasota's beloved service dog, Danielle, retires after providing five years of therapy to the residents and patients at Consulate.


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NFL offseason18 Mar
Matthew Stafford 'knows he can be a better quarterback'
For the Detroit Lions to develop into a consistent organization, QB Matthew Stafford has to get better. And he knows it.
"I think if you ask Matthew, he would take (the blame for last season) all on his shoulders," Lions president Tom Lewand told Detroit Free Press' Dave Birkett. "That's the kind of guy that he is. He knows he can be a better quarterback, he wants to be a better quarterback every step of the way. I think he's a very fine quarterback who's got a fiercely competitive streak to him."
Since Stafford threw for 5,038 yards and 41 touchdowns during the 2011 season, his production has decreased in each of the past two campaigns. Stafford's 58.5 completion percentage and 19 interceptions in 2013 was his worst effort since his rookie season.
Lewand to the angry dude: "I understand you put all of our success and failure on Matthew Stafford. We don't."—
Kyle Meinke (@kmeinke) March 17, 2014
The Lions decided to replace Jim Schwartz as head coach after five seasons with an offensive mind in Jim Caldwell in order to get Stafford back on track.
MORE: Caldwell says Stafford's maturity will help development
At 26, the former No. 1 overall pick is far from a lost cause. Nor is he the entire problem with a Lions team that won only 11 games the past two seasons.
Stafford does have multiple bad habits he needs to correct. He relies far too heavily on his arm, which is among the strongest in the NFL. The ball explodes off his hand, but it also makes Stafford lazy in regards to his technique. The Lions' quarterback rarely marries his feet with eyes, which will cause erratic and inaccurate passes. He continually throws off balance. And he'll change his arm angles even when it's not beneficial to do so.
While Stafford needs to continue to work on the little things, he also needs help from receivers.
The Lions were among the league leaders in dropped passes. Stafford's touch on passes can be inconsistent and he'll release them at all angles, but his receivers need to be more consistent in catching the football.
Stafford will get help from the team's newest addition. Golden Tate signed five-year deal worth $31 million with the Lions Wednesday.
Tate will pair with Calvin Johnson to form a dynamic duo at wide receiver. More importantly, Tate is one of the most reliable receivers in the NFL.
Golden Tate has dropped 5 of 149 catchable passes in the last 3 seasons, lowest rate of any WR. Best hands in the NFL. #Lions—
Pete Damilatis (@PFF_Pete) March 12, 2014
Tate commending Matt Stafford for being able to make all the throws. "I see this offense opening up a lot, and I want to play a huge role"—
Kyle Meinke (@kmeinke) March 12, 2014
With improved technique and a higher level of play from his receivers, Stafford could stop his downward trend as a passer and return to the promising young quarterback he was two seasons ago.


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Programmes A to Z - N
Na h-Eilthirich
Eachdraidh eilthireach nan Gàidheal. The epic story of Highland migration
Nairn Across Britain
Ian Nairn takes a critical look at the townscapes and landscapes in which we live
The National Lottery: Break the Safe
Quiz where three pairs of contestants battle it out for a chance to win up to £100,000.
BBC One
The National Lottery: In It to Win It
Dale Winton presents the game show where more people compete for a big money jackpot.
BBC One
Natural World
Wildlife series. In-depth stories of incredible animals with award-winning photography.
BBC Two
Nature's Miracle Orphans
Meet the wild orphans getting a second chance, and the people devoted to saving them.
BBC One
Nature's Weirdest Events
Chris Packham examines some of the weirdest natural events on the planet.
BBC Two
Neighbourhood Blues
Documentary series following police as they confront the problems of troubled communities.
BBC One
Nelson's Caribbean Hell-hole: An Eighteenth Century Navy Graveyard Uncovered
Sam Willis explores how the Caribbean sugar islands were a kind of hell in Nelson's time.
BBC Four
New Tricks
Drama about a police unit made up of retired detectives looking at unsolved crimes.
BBC One
New York Rock at the BBC
Performances from the Ramones, New York Dolls, Television, Blondie, Lou Reed and more.
BBC Four
Live from London and Singapore, the latest international news from the BBC.
BBC News Channel
Comprehensive coverage of the day's important national and international news stories
BBC Two
Viewers' opinions on the coverage of events by BBC News
BBC News Channel
The Next Step
A reality-style drama following a group of dancers at the Next Step Dance Studio
Nicola Benedetti's Indian Serenade
Nicola Benedetti joins the BBC Scottish Symphony Orchestra on a tour of India.
BBC World News
Nina and the Neurons
Pre-school programme. Nina answers questions about science from kids around the country
Nina and the Neurons: Earth Explorers
Nina and her Explorers discover more about planet Earth and the spectacular solar system.
North West Frontier
A British officer rescues a Hindu prince from an uprising in early 20th-century India.
BBC Two
North West Tonight
The latest news, sport and weather for the North West of England.
BBC One
Northern Ireland Deputy First Minister's Questions
Questions to the Deputy First Minister in Stormont
BBC Parliament
Northern Ireland First Minister's Questions
Questions to the First Minister from the Northern Ireland Assembly.
BBC Parliament
Now's the Hour
Teenagers create a play to help prepare for the decision on Scottish independence.
BBC Two
Nowhere Boys
Mystery adventure. Four boys' lives change forever after a spooky school trip.
Comedy adventure series in which animated numbers solve mathematical problems


text:
Turkish Cargo launches service from HyderabadRajiv Gandhi International Airport in Hyderabad on Thursday expanded its network in the global air cargo map, with Turkish Cargo launching freighter operations from here. Turkish Cargo will operate its Airbus A330-200F freighters, with plans to ... Hindu Business Line, 4 days ago
Turkish Cargo's new Hyderabad freighter services - Air Cargo News, 3 days ago
Oltmans to conduct clinic for hockey coaches - Prokerala, 6 days ago
9 images for rajiv gandhi international
Turkish Cargo launches operations from Hyderabad
Turkish Cargo has launched freighter operations here on Thursday from Rajiv Gandhi International Airport (RGIA), operated by GMR Hyderabad International Airport Limited (GHIAL). It will operate Airbus A330-200F freighters increasing the frequency ...Business Standard India, 4 days ago
3 eve-teasers arrested for teasing airhostesses
3 youth were arrested for eve-teasing at Rajiv Gandhi International Airport, Shamsabad. The youth were teasing airhostesses at Novotel Hotel at the airport. According to details 3 youth Saleh Bajabar (29), Salam bin Hasan (29) and Syed Samee (26) ...Siasat Daily, 1 week ago
Rajiv Gandhi's 70th birth anniversary today; more news updates of August 20
New Delhi, Aug 20: From international to national and sports, go through today's news in brief for latest news updates. 12.14 pm: Pak High Commissioner Abdul Basit said that their priority was to promote regional peace. 'We have lost 15000 people to ...One India, 1 week ago Fresh firing in Assam, several injured; more news updates of August 20 Oneindia, 1 week ago
Monkey business ends at Hyderabad airport
The marathon monkey chase at the Rajiv Gandhi International Airport (RGIA) finally ended on Monday afternoon with zoo officials using an 'immobilization dart' to tame the hyperactive creature that had, over the last 48 hours, been sprinting from one part ...Times of India, 2 weeks ago
Escalator of Shamsabad airport stops all at once, 3 injured
Hyderabad, August 11: 3 people injured as the escalator of Rajiv Gandhi International Airport, Shamsabad stopped all of a sudden. According to details a crowd boarded on the escalator of Rajiv Gandhi International Airport at the same time as a ...Siasat Daily, 3 weeks ago Hyd airport to stop sale of entry tickets ahead of Ind Day Business Standard, 4 weeks ago Rajiv Gandhi International Airport restricts entry of visitors ahead of Independence day Deccan Chronicle, 4 weeks ago Hyderabad Airport to Stop Sale of Entry Tickets Ahead of Independence Day New Indian Express, 4 weeks ago
Sneaky simians scare passengers at RGIA
Two monkeys had a field day at the Rajiv Gandhi International Airport at Shamshabad on Saturday after they clandestinely made their way into the airport premises and merrily made a 'trip' from the domestic to the international terminal spreading panic ...Times of India, 2 weeks ago
Committee recommends internal reservation for displaced tribals
The High Court Committee report on the Tribal Issues of Rajiv Gandhi National Park, Nagarahole, has recommended the State government for internal reservation of tribals, who have been displaced due to various factors, including declaration of national park ...Deccan Herald, 3 weeks ago
Chennai Doctors Remove 152 Metallic Objects from Woman's Abdomen
When 35-year-old Lakshmi (name changed), of Vyasarpadi, was brought to the internal medicine department at Rajiv Gandhi Government General Hospital, Chennai, in December 2013 with issues of loss of appetite and weight loss, doctors thought she ...MedIndia, 3 weeks ago Dumbfounded doctors find 152 metal objects inside woman's stomach Kicker Daily News, 3 weeks ago
Temporary ban on visitors at RGIA
Comment · print · T T T+· T- The entry of visitors inside the Rajiv Gandhi International Airport complex will be banned from August 5 and 20 in view of increased security measures for Independence Day. There will be no sale or issue of ...The Hindu, 4 weeks ago
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Out of Time (2003)
Average Rating: 6.4/10
Reviews Counted: 146
Fresh: 95 | Rotten: 51
A fun and stylish thriller if you can get pass the contrivances.
Average Rating: 6.8/10
Critic Reviews: 38
Fresh: 31 | Rotten: 7
A fun and stylish thriller if you can get pass the contrivances.
liked it
Average Rating: 3.3/5
User Ratings: 58,229
Movie Info
Director Carl Franklin and actor Denzel Washington team up again (following 1995's Devil in a Blue Dress) for the crime thriller Out of Time. Washington stars as Matt Lee Whitlock, the well-respected chief of police in a quiet Florida community. While in the process of getting a divorce from fellow detective Alexandra (Eva Mendez), Matt engages in an affair with his high school sweetheart Anne (Sanaa Lathan). Unfortunately, Anne is married to the extremely jealous Chris (Dean Cain), a former pro
Oct 3, 2003 Wide
Jan 6, 2004
MGM/UA - Official Site
Watch It Now
Denzel Washington
Matt Lee Whitlock
Eva Mendes
Alexandra Diaz Cole
Sanaa Lathan
Ann Merai Harrison
Dean Cain
Chris Harrison
Tony Dalton
Robert Baker
John Billingsley
Robert Baker
Tony Dalten
Antoni Corone
Deputy Baste
Alex Carter
Dr. Cabbot
Terry Loughlin
Agent Stark
Nora Dunn
Dr. Donovan
James Murtaugh
Dr. Frieland
Tom Hillmann
Robert Guillette
Ed Amatrudo
Arson Investigator
Arian Waring Ash
Dental Assistant
Jesse B'Franklin
Evelyn Brooks
Judy's Mom
Neil Brown Jr.
Morgue Attendant
Parris Buckner
Dr. Shider
O.L. Duke
Detective Bronze
Elena Maria Garcia
Sharlene Garcia
Suzanne Grant
Screaming Woman
Dorothy A. Healy
Woman in Lobby
Eric Hissom
Hotel Clerk
Veryl E. Jones
Agent Fetzer
Ronald J. Madoff
David J. Negron Jr.
Sketch Artist
Mike Pniewski
Agent White
Steve Raulerson
Man Serving Divorce ...
Peggy Sheffield
Judy Anderson
Tim Ware
Fire Chief
Michael Pniewski
Agent White
Latest News on Out of Time
November 21, 2006:Critical Consensus: "Halls" Spreads Little Cheer; "D�j� Vu" Intrigues; "The Fountain" Overflows; "Pick" Is Mixed
This week at the movies, we've got holiday mischief ("Deck the Halls," starring Matthew...
March 23, 2006:Critical Consensus: "Inside Man" is Certified Fresh, Second Best-Reviewed Wide Release Of
Tension: it's the key to many a film, and this week's wide releases bring three variants on that...
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All Critics (157) | Top Critics (41) | Fresh (95) | Rotten (51) | DVD (32)
Franklin is known for being good with actors, but Out Of Time also reveals his flair with machines, which too often dominate the plots of latter-day noirs.
A well-performed, perfectly watchable thriller that's nonetheless as generic as its title.
This generically titled mystery thriller is slow to catch on but holds joyous moments of suspense once it kicks in.
In spite of decent performances from the main cast, Carl Franklin's thriller is listless and very weak.
Franklin seems to be aware that the audience knows what is going to happen.
The suspense is killing, but the sense of being in the hands of a skilled storyteller is relaxing, too. Out of Time is a blast without making you work for it.
I have a policy about life insurance policies in movies like this: Don't be the beneficiary. Just don't do it. Nothing good ever comes of it.
O roteiro acaba negligenciando um aspecto que deveria ser importante para o her�i: a intelig�ncia.
Only good enough to remind of the kind of filmmaker that Franklin has been and, hope springing eternal, could be again.
More exciting than smart or chic or witty, Out of Time is relaxing, delightfully old-fashioned entertainment.
Denzel Washington has never made better use of his screen persona than he does in Out of Time, a slick crime thriller from director Carl Franklin.
Director Carl Franklin previously worked with Washington in the criminally overlooked Devil in a Blue Dress, and he gets a solid performance out of him here again.
It's funny that this movie was called "Out of Time" because it sure seemed like some scenes had plenty of time to drag.
Without Denzel Washington's charm - the cocked head, the sly, toothy grin and eyes that scream 'trust me' - a thriller as lame and preposterous as 'Out of Time' would just sink back into the lethargic swamp of sweat-soaked neo-noir that seems to seep in e
a well-made, well-acted and entertaining suspense story that works more often than not.
...the dreary formulaic plot supported by scattered pedestrian performances doesn't reinforce the distinctive urgency and edginess this uneven crime caper valiantly tries to promote.
We laugh at each new twist and turn, but we're also fascinated by how the hero will get himself out of each new dilemma.
Audience Reviews for Out of Time
Super Reviewer
The pressure felt by the main character in the movie is portrayed well and felt throughout and provided a constant feeling of frustration of 'if only you'd just ....'
Very enjoyable, a great understated Trhiller.
Super Reviewer
Super Reviewer
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A game for two people, or play online. Given a target number, say 23, and a range of numbers to choose from, say 1-4, players take it in turns to add to the running total to hit their target.
Got It game for an adult and child. How can you play so that you know you will always win?
A game for 2 players that can be played online. Players take it in turns to select a word from the 9 words given. The aim is to select all the occurrences of the same letter.
Nim-7 game for an adult and child. Who will be the one to take the last counter?
Can you work out how to win this game of Nim? Does it matter if you go first or second?
Slide the pieces to move Khun Phaen past all the guards into the position on the right from which he can escape to freedom.
First Connect Three game for an adult and child. Use the dice numbers and either addition or subtraction to get three numbers in a straight line.
A game for 2 players. Can be played online. One player has 1 red
counter, the other has 4 blue. The red counter needs to reach the
other side, and the blue needs to trap the red.
A game for 2 or more people, based on the traditional card game
Rummy. Players aim to make two `tricks', where each trick has to
consist of a picture of a shape, a name that describes that shape,
and. . . .
The idea of this game is to add or subtract the two numbers on the dice and cover the result on the grid, trying to get a line of three. Are there some numbers that are good to aim for?
Take turns to place a decimal number on the spiral. Can you get three consecutive numbers?
Two sudokus in one. Challenge yourself to make the necessary
An article for teachers and pupils that encourages you to look at the mathematical properties of similar games.
Here is a machine with four coloured lights. Can you develop a strategy to work out the rules controlling each light?
Advent Calendar 2010 - a mathematical game for every day during the
run-up to Christmas.
A Sudoku that uses transformations as supporting clues.
A game for 2 players with similaritlies to NIM. Place one counter on each spot on the games board. Players take it is turns to remove 1 or 2 adjacent counters. The winner picks up the last counter.
There are nasty versions of this dice game but we'll start with the nice ones...
A game that tests your understanding of remainders.
Interactive game. Set your own level of challenge, practise your table skills and beat your previous best score.
Can you make the birds from the egg tangram?
Can you spot the similarities between this game and other games you
know? The aim is to choose 3 numbers that total 15.
A game for 2 players. Given an arrangement of matchsticks, players
take it is turns to remove a matchstick, along with all of the
matchsticks that touch it.
A game in which players take it in turns to try to draw
quadrilaterals (or triangles) with particular properties. Is it
possible to fill the game grid?
The aim of the game is to slide the green square from the top right
hand corner to the bottom left hand corner in the least number of
Start with any number of counters in any number of piles. 2 players
take it in turns to remove any number of counters from a single
pile. The winner is the player to take the last counter.
A simple game of patience which often comes out. Can you explain
Basic strategy games are particularly suitable as starting points
for investigations. Players instinctively try to discover a winning
strategy, and usually the best way to do this is to analyse. . . .
Here is a solitaire type environment for you to experiment with. Which targets can you reach?
We think this 3x3 version of the game is often harder than the 5x5 version. Do you agree? If so, why do you think that might be?
A shunting puzzle for 1 person. Swop the positions of the counters at the top and bottom of the board.
Practise your diamond mining skills and your x,y coordination in this homage to Pacman.
This pair of linked Sudokus matches letters with numbers and hides a seasonal greeting. Can you find it?
This article for teachers describes several games, found on the
site, all of which have a related structure that can be used to
develop the skills of strategic planning.
Given the products of diagonally opposite cells - can you complete this Sudoku?
How good are you at estimating angles?
A collection of games on the NIM theme
In this matching game, you have to decide how long different events take.
This is an adding game for two players.
A game for 2 people. Take turns placing a counter on the star. You
win when you have completed a line of 3 in your colour.
Investigations based on an Indian game.
A game in which players take it in turns to turn up two cards. If
they can draw a triangle which satisfies both properties they win
the pair of cards. And a few challenging questions to follow...
This sudoku requires you to have "double vision" - two Sudoku's for
the price of one
Spiralling Decimals game for an adult and child. Can you get three decimals next to each other on the spiral before your partner?
A game for 1 person to play on screen. Practise your number bonds
whilst improving your memory
A game for 2 people that everybody knows. You can play with a
friend or online. If you play correctly you never lose!
Some Games That May Be Nice or Nasty for an adult and child. Use your knowledge of place value to beat your oponent.
The computer starts with all the lights off, but then clicks 3, 4
or 5 times at random, leaving some lights on. Can you switch them
off again?
Can you discover whether this is a fair game?