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Category: Futuring, Demographics, Generations
The day after President Obama delivered his State of the Union speech, Jim Blasingame delivers his State of Small Business Address. He talks about the difference between a worldview that seeks a government approach to solutions, and a worldview that seeks market-based solutions.
The future of your business is in the clouds, according to Maia Sisk, who joins Jim Blasingame to talk about cloud computing, which is processing power that doesn't reside on your desktop but from the Internet, from the smallest cell phone applications to multiple participant collaborations.
How do paradoxes impact the performance of our small businesses, especially in a recession? Kelle Olwyler talks with Jim Blasingame about how to identify paradoxes and actually take advantage of them.
What do you have, as a small business owner, that big business CEOs envy? Jim Blasingame talks about some of the advantages small businesses have that they should be leveraging everyday. He also talks about building better banking relationships.
What is your mission and purpose of your small business? After he reports on his most recent trip to Russia, and what he found there, Jim Camp talks with Jim Blasingame about why your mission and purpose is important.
What can small business learn from watching Google, including their visionary approach to the 21st century, their successes and their mistakes. Jeff Jarvis joins Jim Blasingame to talk about some of the specific lessons Google is teaching everyday.
What innovations are coming at you that could create profit or peril for you small business? Futurist, Joel Barker talks with Jim Blasingame about a number of "innovations at the verge" that small businesses should know about.
Could a well-developed and nurtured network help your small business avert a disaster? Amit Mukherjee joins Jim Blasingame to talk about his "Spider Strategy" which will help companies create networks to avert crisis, create change and seize opportunities.
Every small business has trade secrets. The question is how are you leveraging and protecting them? David Dawsey joins Jim Blasingame to talk about this important small business intellectual property issue.
Is the government's approach to stimulating the economy really going to do that and will it be good for small business? Tony Paradiso and Jim Blasingame talk about some of the details and explain why the bill is more pork barrel spending than stimulus.
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Think long term for bikes, ministers toldPublished at 12:01AM, August 27 2014
Ministers should be forced to commit to long-term funding for safe cycle routes, according to campaigners
Friends pay tribute to Dan Harris, cyclist killed in collision
The cyclist killed in an accident near the Olympic Park in London last night was identified today as a young web specialist who had begun riding his bike to work only last week.
Dan Harris, 28, was pronounced dead at the scene after being hit by a media shuttle bus on edge of the Olympic Park in Stratford. The driver of the bus, who is in his sixties, was arrested on suspicion of causing death by dangerous driving and has been given police bail.
Friends paid tribute today to Mr Harris, who described himself as a freelance community manager with an online printing firm and posted on Twitter under the handle @gecko84. Apart from cycling he also enjoyed kayaking and mountain-climbing.
"Words fail me," one tweeted. "Dan, you were a wonderful friend, localgov enthusiast, life of the party... How very sad," another friend wrote.
According to postings on Mr Harris's own Twitter page, he started commuting regularly only last Monday, cycling almost seven miles each way from his office in Shoreditch to his home in Wanstead, Essex. The route took him around the edge of the Olympic Park, where the accident happened, and included several busy stretches of highway.
But Mr Harris clearly believed in safe and responsible cycling. In one tweet last week he wrote: "I've taking to loudly boo-ing #cyclists who jump red lights. They give the rest of us a bad name and should be publicly shamed."
The Metropolitan Police said that police were called at 7.42pm after the collision at Ruckholt Road (A106) junction with the East Cross Route (A12). Mr Harris, whom the Met formally identified today, was pronounced dead at 8.14pm.A post-mortem examination is due to be held tomorrow.
The tragedy shocked many around the London Olympics and prompted Bradley Wiggins, who won the men's time trial only hours beforehand, to question current road safety laws.
"Ultimately, if you get knocked off and you don't have a helmet on, then you can't argue. You can get killed if you don't have a helmet on," Wiggins said.
"You shouldn't be riding along with iPods and phones and things on. You have lights on. Once there are laws passed for cyclists then you are protected and you can say, 'Well, I have done everything to be safe'.
"There are a lot of things that need to be addressed with cycling at the moment on the roads. Things can't continue the way that they are, everybody knows that."
Wiggins - who later denied that he was calling for helmts to be made compulsory - is among a group of leading figures in the cycling world who have backed The Times campaign for safer cycling on Britain's roads.
Witnesses suggested that Mr Harris had been hit by the bus as it turned left and may have been in the driver's blind spot.
One user on the social news website Reddit claimed to have been riding home alongside Mr Harris but held back as they approached the bus, "while he went inside".
The user, identified as mrcjp, wrote: "The lights changed as he was in the buses blind spot and as he was attempting to go straight the bus turned left. He didn't really have anywhere to go and no time to do anything anyway... he got pulled under the wheel and dragged around 10 feet or so."
The definitive guide to keeping your eyes in shape, from lifestyle choices to new technology
Fruit for the Office take strides into the 21st century with mentoring from YO! Sushi founder
New research shows that if you invest in Britain's bus network, you open the door to economic expansion
Share the best with your family, for less. Find great deals and quirky holiday options with our guide
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Ministers should be forced to commit to long-term funding for safe cycle routes, according to campaigners
Inspired by Olympic success and the Tour de France, cycling has exploded in popularity with bikes now status symbols costing up to £25,000
Most dangerous junction in Britain, as identified by Times readers, to be ripped up and redesigned to make it safer for cyclists, pedestrians and drivers
The first roundabout to incorporate separate cycle lanes is to open next year, though some safety campaigners said it would be confusing
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subset: commoncrawl


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The Daily Breeze, August 2
Posted on August 1, 2012
Week 30 Thursday August 2, 2012 Sunrise and Sunset 5:42 am 8:17 pm Local Weather (Subject to Change!) Keep those swimming suits and trunks close at hand! Today we can look forward to mostly sunny skies and a high of 89 degrees in the afternoon. Group News Basin Harbor Club is delighted to welcome back […]
The Daily Breeze, July 25
Posted on July 25, 2012
Week 29 Thursday July 26, 2012 Sunrise and Sunset 5:34 am 8:25 pm Local Weather (Subject to Change!) Showers are likely throughout the day, with the high reaching a modest 74 degrees. Perhaps it's a good day to catch up on your book! Group News Basin Harbor Club is delighted to have with us the […]
Posted on March 19, 2012
Greetings from your BHC Family – It may be a false spring but all of us here at Basin Harbor are loving these balmy, sunny days – it's truly weather that you'd enjoy tremendously in May when we've just opened! Still, I'm not taking my snow tires off just yet – I recall late season […]
Winter Fun
Posted on February 28, 2012
Some people wonder what we do here all winter. No skiing this year, although March is often the snowiest month, so we're keeping our fingers crossed on that score. We love food and cooking, so we spend a lot of time in the kitchen! We – well, I – love to buy cookbooks, and I'm […]
Pancakes All Day Long!
Posted on
Today is National Pancake Day! One of the best reasons to have breakfast for dinner. What's your favorite indulgence for pancakes, either flavor or toppings? Mine is the Joy of Cooking's recipe that calls for 2…yes 2 sticks of butter. All things in moderation?


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from Dow Automotive Systems
Ready to use solvent-borne primer for use with various cover-coat [See More]
- Chemical System: Elastomeric
- Features: Sealant; Solvent Based
- Cure / Technology: Peroxide
- Substrate Compatibility: Rubber or Elastomer
from Dow Polyurethanes
LOW MODULUS HIGH EARLY STRENGTH PATCHING SYSTEM A two-component, low modulus, high early strength epoxy system and a special blend of properly graded dry silica aggregate. The MARK-120.1 Patching System provides a chemically inert, highly abrasion resistant surface when applied on a properly... [See More]
- Chemical System: Epoxy
- Type / Form: Liquid
- Cure / Technology: Thermoset; Two Component
- Substrate Compatibility: Concrete, Masonry
from Grainger Industrial Supply
Construction Adhesive, Latex, Off-White, Size 10.1 Oz., Application Time 20 Min, Functional Cure 24 Hours, Coverage 31 Linear Ft @ 1/4 In Bead, Flash Point Greater Than 200 F, Operating Temp. Range Up To 120F, Temp. Range Up To 120F, VOC Content 2 g/L, Adheres To Most Surfaces Such As Concrete,... [See More]
- Features: Sealant
- Use Temperature: 120
- Substrate Compatibility: Ceramic, Glass; Concrete, Masonry; Metal; Plastic; Wood
from Anti-Seize Technology
Resists chemicals, temperature extremes, weather, vibration, moisture [See More]
- Chemical System: Silicone
- Features: Sealant
- Cure / Technology: Air Setting / Film Drying
- Substrate Compatibility: Ceramic, Glass; Metal; Plastic; Wood
from BRD Noise & Vibration Control, Inc.
Pliable seal against airborne sound, air infiltration and moisture. Adheres to wood, metal, concrete, gypsum board and other construction materials and building substrates. Maintains STC value (Sound Transmission Class) of sound rated walls, systems and assemblies. Non-hardening and non-migrating. [See More]
- Features: Sealant
from Chemical Strategies, Inc.
Chemical Strategies offers all Krylon products. If you are unable to locate a paint or coating you need, our sales department can custom source any needed materials for you directly. [See More]
- Features: Sealant


text:
I had two times in this place. The price wasn't too expensive, and the room is good for take some rest. Toilet also good. Big enough for me. The minus was it placed at housing. So I need more time to find it. And it needs more car parking area. 'cause in the weekend parking area is full. So I... More
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Hotels.com, Agoda, Travelocity, Tingo, Expedia, BookingOdigeoWL, HostelWorld and Venere so you can book your Family Guest House reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Family Guest House Hotel Surabaya
- Family Guest House Surabaya, Java


text:
(Video Link)Like the sound of creme brul... ...enjoy this video by Nerdy Nummies that shows you how tohttp://www.neatorama.com/2013/06/13/Creme-Brulee-Dragon-Ball-Z-Cakes/
How to get a woman mad in two easy steps: 1. Take a pict... ...steps: 1. Take a picture of her. 2. Don't show it to her.— JD (@JohnDuffy21) April 24, 2013 ~... ...~Get this on a T-shirt over at the Twaggies Shop: How to Get a Women Mad in Two Easy Stepshttp://www.neatorama.com/2013/05/20/woman-zombie-cartoon/
HOW TO SURVIVE IN THE WILDERNESS: Call someone and have...http://www.neatorama.com/twaggies/2013/03/22/how-to-survive-in-the-wilderness-cartoon/
The Rocketeer is always a great costume choice, bu... ...great costume choice, but while you might be able to design a mask from a milk carton or paper mache,... ...tely, Instructables has a handy set of directions tohttp://www.neatorama.com/halloween/2012/10/10/How-to-Make-A-Rocketeer-Rocket-Pack/
(Video Link) Yes, Comic Con costume photos will... ...oming later this week, but if you just can't wait to enjoy some great cosplay, you can always follow t... ...cosplay, you can always follow these instructions tohttp://www.neatorama.com/2012/07/14/how-to-make-your-own-dalek-dress/
Have you ever wondered how people create such amazing looking art GIFs, and... ...le create such amazing looking art GIFs, and want to make your own? Master of GIF animation Anthony... ...nimated GIF art of your very own! Hit the link to Anthony's website and he will...http://www.neatorama.com/2012/06/30/how-to-make-your-own-amazing-gifs/
(YouTube link) First, there's the how . And then there are several good reasons why. Get... ...why. Get the charcoal out -I think I'll try this tonighthttp://www.neatorama.com/2012/06/28/why-you-should-spiral-cut-your-wiener/
In this 60-second tutorial, my son, the Smart... ...�tutorial, my son, the Smart Aleck, will show you how to close out of an app completely. It's the equival... ...tery last longer. In others, well, it's just good to know how to close out of an app 100%.http://www.neatorama.com/2012/05/08/how-to-close-apps-on-an-iphoneipad/
These colorful piñata cookies are as tasty as... ...ld the hollow burro, fill with candy, and be sure to take pictures before they are eaten. Sandra Denne...http://www.neatorama.com/2012/04/26/cinco-de-mayo-pinata-cookies/
(YouTube link) Yesterday, Matthew Inman posted... ...st, he suggested someone write a sing-along about how tohttp://www.neatorama.com/2012/04/13/this-is-how-you-load-a-dishwasher/


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Children's Program
Baby Story TimeSubmitted by oplin on Tue, 06/10/2014 - 1:48pm
For babies and toddlers up to 36 months. Songs, stories, rhymes and other fun for the very young. Wednesday and Friday mornings in the Early Literacy Center.
Fri, 10/10/2014 - 9:45am - 10:15am
Rock-N-Roll Ice CreamSubmitted by oplin on Mon, 06/09/2014 - 10:15pm
Here's the scoop. Let's meet in the Lindamood Room at 6:30 p.m. and make homemade ice-cream in a fun family activity.
Mon, 07/07/2014 - 6:30pm - 7:30pm
Mad Scientist ProgramSubmitted by oplin on Mon, 06/09/2014 - 10:13pm
Mad Scientist Program. Get ready to be dazzled with interactive science experiments. Discover the energy in our lives and in our Earth presented by Deb Wickerham. All ages welcome. Please register online or at the Children's Services desk.
Mon, 06/30/2014 - 1:00pm - 2:00pm
Non library eventSubmitted by oplin on Fri, 06/06/2014 - 4:51pm
mini magic miniature club
Wed, 09/17/2014 - 6:00pm - 8:30pm
Lengendary Story Time with Andy Armadillo. June 24. 2:00 p.m.Submitted by oplin on Fri, 06/06/2014 - 9:28am
Legendary Story Time with Andy Armadillo (mascot for Texas Roadhouse Restaurants). For ages 3-8 years old. Join Andy for fun stories about Armadillos.
Tue, 06/24/2014 - 2:00pm - 3:00pm


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Is it still necessary to use em's and avoid javascript for Accessibility?
Ever since I've started posting here I've had @deathshadow60 on my back about accessibility - which is a good thing as I would of never considered it otherwise. And as a result I've been trying to avoid javascript as much as possible and have been using em heights.
But I've been doing some reading:
These articles state that all modern browsers can zoom correctly with pixel-sized fonts and only 1.6% of those using screen readers have js disabled.
Do you agree with these articles, in that I can go around setting fixed-pixel fonts and using javascript without worrying about it affecting accessibility? Are these accessibility concerns over a decade old?


text:
Bike Map in Gray County, TX
Bike Map Gray County, TX - Trails.com
Gray Trails | Gray Parks | Georgia
Find detailed information for Gray Georgia city trails on Trails.com, ... The Gray Squirrel's County Cousin: ... Site Map; Hotels;
Texas RV Parks | Trails.com - Hiking Trails, Mountain Bike ...
Trail Maps; Top 100 Trails; ... Texas. The 60-mile-long, round-trip bike trail known as the Hill Country Flyer Challenge begins in ... A city in Gray County, Texas, ...
Gray Trails | Gray Parks | Maine - Hiking Trails, Mountain ...
Gray Trails & Gray Parks Find trails near Gray Maine, including Gray parks, Gray walks and Gray bike paths. ... Site Map; Hotels;
Texas Topo Maps | Topographic Map Data for Texas State ...
Anderson County, TX Texas Topo Maps; Andrews County, TX Texas Topo Maps; Angelina County, TX Texas Topo Maps; Aransas County, TX Texas Topo Maps; Archer County, TX ...
Gray Trails | Gray Parks | Pennsylvania
Trail Maps; Top 100 Trails; ... including Gray parks, Gray walks and Gray bike paths. Sullivan Run, Sullivan County :: Red Rocks, PA. To get ...
Bike Map in Gray County, TX Information from the Government
TXDMV.GOV - Gray County Tax Office
... Map & Directions Use the map below to get directions to your county tax office. View Larger Map ... Gray County Tax Office ... www.co.gray.tx.us/
Maps - Houston
Houston Bikeways. Find information on bike trails safety ... Montgomery County; State of Texas; ... The map also shows trails built by Harris County that are within ...
Gray County QuickFacts from the US Census Bureau
Maps, Geographic Data. About; Education; GSS Initiative; Interactive Maps; Maps & Data; ... Gray County Texas; Population, 2013 estimate : 23,043: 26,448,193:
National Weather Service
Gray County Zone Forecast. ... Severe Weather Current Outlook Maps Drought Fire Weather ... National Weather Service Amarillo, TX Comments?
Texas QuickFacts from the US Census Bureau
Texas County Map. ... Pages are available for the following cities and towns in Texas:
Bike Map Gray County, TX - Recreation.gov
Facility Details - MURRELL PARK, TX - Recreation.gov
... fishing and boating in Texas. ... Map: Site List: Date Range Availability: ... Texas in Tarrant County. Directions from Dallas, Fort Worth and Denton.
Facility Details - SANDY CREEK, TX - Recreation.gov
Sandy Creek Park is located on the southeast side of B.A. Steinhagen ... Turn south on FM 777 and travel 2 miles to County Road ... Print Facility Map; Texas State ...
Recreation.gov recreation area details - Lake Umbagog ...
View Official Website > View Map > BACK TO SEARCH. ... Located in Coos County New Hampshire and ... (Portions toll) Exit 11 toward Gray, ME. Keep right at the ramp ...
Facility Details - WENCH CREEK, CA - Recreation.gov
The Union Valley Bike Trail and Bassi Falls Hiking Trail are worth exploring. ... bobcat, gray fox, bighorn sheep, pikas, martens and a ... Print Facility Map ...
Search for Places - Recreation.gov
Camping and Lodging will let you search for available campsites and other overnight sites that fit your needs.


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I bought a new computer
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text:
I don't think I'd like to know the answer unless it's me.
The you I loved yesterday is the same you I love today, and the same you I will love tomorrow.
(via kimpoyfeliciano)
(via kimpoyfeliciano)
I was only temporary to you.
6 word story by K.L (via aztecianlipstick)
(Source: , via borinq)
"what's being a history major like?"
(via thestrayline)
nothing will fuck you up as much as the realization that there's no real reason the alphabet needs to be in order
(via cumfort)


text:
Over 2,000 people marched through the streets of São Paulo Saturday. It was the city's 460th anniversary, but they weren't there to celebrate.
These were the first anti-World Cup demonstrations of 2014. And though they started peacefully, they quickly erupted into violence. Anarchists attacked an empty police car. Others torched a private vehicle and damaged storefronts. After breaking up the crowds with tear gas and rubber bullets, police announced that 128 people had been arrested. São Paulo Governor Geraldo Alckmin condemned the violence, and the city cancelled some of its anniversary events.
In 2013, millions of Brazilians voiced their anger over political corruption, substandard public transit and underfunded social programs. Why, they asked, was the government willing to spend freely on an international event when it couldn't provide even basic public services to the country's nearly 200 million inhabitants?
President Dilma Rousseff eventually pledged $25 billion in transit improvements and proposed a referendum on political reform last summer. But Rousseff's efforts have not quelled protesters, who held signs and chanted "there will be no World Cup." One participant told the Guardian, "this is a small sample of the protests that will happen when the World Cup begins."
Smaller demonstrations took place in Rio de Janeiro, where about 50 people gathered, holding anti-World Cup signs before marching down a major city street and delaying traffic. Fifteen people were arrested at a protest in the city of Natal near their new soccer stadium, which officially debuted last week.


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WILLIAMSTON — Water is seeping through a coal ash dam in the foothills of South Carolina, raising concerns about the structure's stability and whether a failure would contaminate the Saluda River.
But the seepage at Duke Energy's power plant in Anderson County has gone largely unnoticed as environmental groups and federal prosecutors focus much of their attention on the company's troubles in North Carolina.
Duke, the energy giant with headquarters in Charlotte, finds itself in the middle of a criminal investigation in the Tarheel State and company officials are trying to explain why they couldn't prevent a major coal ash spill into the Dan River near the Virginia border.
Since Duke has 14 coal ash sites in North Carolina, it makes sense the attention would not be focused on the two places in South Carolina that Duke owns.
Records show, however, that environmental concerns have turned up at both of the utility's ash sites in South Carolina, most prominently along the Saluda River between Greenville and Anderson. The company's other coal ash site is in Darlington County.
In 2010, consultants for the U.S. Environmental Protection Agency noted elevated water levels at one of the Anderson County coal pond dams and a history of seepage along the base of the other. Those issues could compromise the safety and stability of both structures, the report for the EPA said.
The report, prepared by GEI Consultants Inc., classified the ash pond dams as a "significant hazard" to the Saluda River because of the environmental impact they could have if a collapse occurred. A breach to the dams, which impound 64 acres of coal ash and wastewater, could send a large amount of ash into the Saluda, the report said.
GEI's study didn't find an imminent threat of failure from the coal pond walls, but it recommended monitoring seepage at the base of one dam. Evidence compiled during a site visit indicated seeps had been occurring for nearly a quarter century along what is known as the site's "secondary ash pond" dam.
It wasn't clear from the report whether the seeping water is coming from the coal ash ponds or is groundwater welling up into the dam. But excess water in an earthen dam can erode the structure and destabilize it.
"The main issue of potential concern for the (ash) impoundments identified in our field assessment was the flowing water and the soft wet soil" below one of the two ash dams, according to the December 2010 study. "Duke Energy personnel indicated that the seepage has been present for at least 24 years."
Duke conceded last week that seepage still is occurring from the dam, but said that's not abnormal and that the structure is safe. State regulators also said they believe both dams are stable, although they said the power company is making modifications.
"Some seepage through an earthen dam is common," Duke spokesman Ryan Mosier said, but he emphasized that "seepage monitoring indicates no unusual conditions to date."
Coal ash critics don't see it that way.
In addition to concerns about the dams in the GEI report, the study questioned whether the foundation of the polluted ash ponds and dams could withstand an earthquake.
Previous studies, relying on a method of measuring soil stability known as a "blow count," showed the earth beneath the Anderson County ponds and dams is relatively soft, said Steve Jaume, an earthquake specialist at the College of Charleston after The State newspaper made him aware of the study.
How dangerous are spills?
Spills from coal ash lagoons can be devastating to the environment.
A spill that occurred this month at a Duke site on the Dan River of North Carolina sent toxins into the water, threatening fish and aquatic organisms. Duke finally plugged a leaking pipe and announced plans to dredge the river after the water turned gray with ash. A second leak also has been stopped. Federal officials now are asking whether state regulators were diligent enough in monitoring the coal pond.
The worst spill in U.S. history occurred in Kingston, Tenn., about five years ago, when a coal dam broke and sent a wave of poisoned water into rivers. The deluge killed fish and drove people from their homes.
Coal ash is the residue of burning the fossil fuel to make electricity. It contains an array of toxins. Those often include arsenic, selenium and mercury, all poisons that can cause health problems or even death to people and animals who come in contact with the pollutants. Some aquatic animals regularly exposed to coal ash develop deformities.
In addition to questions about threats to the Saluda River in Anderson County, groundwater pollution is a concern.
Coal ash ponds operated by both SCE&G near Columbia and Santee Cooper near Myrtle Beach have poisoned groundwater with high levels of arsenic. Unlike Duke's coal ponds, those are slated for cleanup.
At Duke's sites, groundwater does not appear to have the same high levels of contaminants found at other places around the Carolinas. But it is not pollution free, either.
Recent groundwater sampling at Duke's Darlington County site detected an elevated level of toxic chromium in a monitoring well, according to the S.C. Department of Health and Environmental Control.
Chromium exceeded the maximum contaminant level for safe drinking water at the H.B. Robinson coal site just outside of Hartsville, DHEC said in response to questions from The State.
At the company's W.S. Lee site in Anderson County, elevated levels of iron and manganese have shown up, DHEC said.
Peaceful river
Duke Energy's Lee steam station, built in 1951, is nestled in a rural area of woodlands and farm fields about two miles east of Williamston, a small textile town 102 miles northwest of Columbia.
Just downhill from the company's power plant and coal ponds is the Saluda River, a long waterway that extends from the Blue Ridge Mountains to the central Midlands in Columbia.
The source of drinking water for hundreds of thousands of people between Greenville and Columbia, the river also is popular with outdoorspeople. Crappie and catfish fill the river and deer are abundant along its banks. Non-game species also can be found there, including birds that thrive in the tangled habitat.
On a recent winter afternoon near Williamston, a brightly colored kingfisher perched on a tree limb, scanning the waters for its next meal.
Kenny Cooley loves the community and its peaceful nature. But he's concerned about the coal ash ponds at Duke's Lee steam station down the road from his house.
People used to fish in the ash ponds, but the whoppers they caught often carried a petroleum flavor that was hard to get used to, Cooley said last week as he stood in his front yard and looked through a thin veneer of trees at Duke's ash basins. The company no longer allows access to the property, he said.
Worried about groundwater pollution, Cooley said he has tapped onto a public water system to avoid any threat to his family's health.
"I said, 'This might be sinking into our wells,' so I moved" to public water, the 64-year-old barber said. "I'm always worried about carcinogens."
Environmentalists, while conceding that they've been busy with Duke's coal ash basins in North Carolina, said Duke Energy's South Carolina ponds present their own hazards.
Although a breaking coal dam can devastate a river, an unlined waste pond can let toxins ooze into groundwater – and many are unlined, conservationists say.
"People should be very concerned," said Donna Lisenby, a former South Carolina resident now involved in the regional fight over coal fired power plants and contaminated ash basins that serve them.
Coal ponds in five states tested by the Waterkeeper Alliance are leaking, and "most of them aren't safe," Lisenby said. "The most worrisome thing is all the high-hazard dams."
Frank Holleman, an environmental lawyer in Greenville and one of Duke's chief agitators, suggested the possibility of a lawsuit to clean up the South Carolina sites. But he said DHEC should spearhead the cleanup effort since its job is to protect the environment in the Palmetto State.
"The problem is that for years on the Saluda River, the system has not operated properly. The dam has leaked," Holleman said. "That's a warning sign.''
Duke says it is following the law and keeping the South Carolina ash ponds safe.
DHEC records show the agency has cited Duke a handful of times for water pollution violations at its Robinson facility near Hartsville in Darlington County and its Lee steam plant near Williamston. Those citations include a $7,267 fine in 2007 for discharging heated water that killed fish in the Saluda River.
Holleman said the best way for Duke to reduce environmental threats in South Carolina is by digging up all the coal ash it deposited in ponds and hauling it to a landfill. That's especially important since the company has closed the Darlington coal site and is in the process of shuttering the one in Anderson County, where a gas-fired plant will be constructed in its place, he said.
Holleman's organization, the Southern Environmental Law Center, successfully sued two other utilities in South Carolina, SCE&G and Santee Cooper, seeking an ash cleanup. Both companies have agreed to dig out their ash ponds during the next 10 to 15 years and dump the material in landfills or recycle the ash. The decisions have been held up as a model for Duke to follow.
Aside from a complete dam failure, Holleman said even a partial break could pollute the Saluda River because Duke has a pipe to the Saluda to catch pond wall seepage. The pipe could act as a "conveyance" for a rush of polluted water, similar to the pipe discharge on the Dan River, he said.
Safe operation
Duke Energy, which supplies power to much of North Carolina and to northern South Carolina, said there's no reason for the public to be worried about ash dams anywhere – including on the Saluda River east of Williamston or on the flat plains of Darlington County.
The company is committed to safety, Mosier said.
In Anderson County, Duke has responded to questions in the EPA report and is convinced the ash pond dams are in good shape, Mosier said. The company routinely checks dams after heavy rains or earth tremors and has found no problems, he said.
"Analyses indicate the dams are stable in their current condition," Mosier said in an email to The State. "Special inspections are conducted immediately after unusual conditions, such as significant rain and seismic events, to help detect areas that could be distressed and to facilitate immediate repair."
The modification Duke is making to one of its Lee dams is for an outfall structure that carries some drainage water away from the embankments, records show. Erosion – and failures – are less likely if the dams are not saturated with water. Duke's improvements to the dam involve trying to repair a pipe that carries away seepage.
Mosier said seepage water goes through a "toe drain" to the river. That protects the coal ash dam from saturation. The discharge has been approved by state regulators.
Despite calls by environmentalists to clean out the ash basins to reduce the threats, Duke says only that it is studying the future of the ponds near Williamston and Hartsville and it will come up with the most realistic plan for closing the basins.
The company's position on the South Carolina ash ponds mirrors its stance on ash basins in North Carolina, where Duke has resisted efforts by environmentalists to dig out the ash to reduce threats to rivers.
"Closure planning studies are currently under way at many retired North Carolina plants with ash basins, and we plan to follow a similar process in South Carolina,'' Mosier said.
"Our focus is developing closure plans that will protect the environment, neighbors and customers. Each site is different with respect to soils, hydrology and other aspects that inform our planning, so we will leave it to the science to tell us what closure approach will be the best fit for W.S. Lee and Robinson."


text:
Ductal carcinoma in situ of the breast: a new phenotype classification system and its relation to prognosis.
ABSTRACT In a study of invasive breast cancer, multiple correspondence analysis (MCA) revealed clustering of eight pathobiological variables. Two different phenotypes were distinguished by an index calculated on the basis of the variables (histologic grade, necrosis, lymphoid infiltration, number of mitosis and expression of c-erbB-2, p53, progesterone receptor and Bcl-2). Phenotype A lesions share most of the features of normal breast tissue. Phenotype B looks more malignant, has a higher early recurrence rate and is more frequently seen in younger patients. Our aim was to see if ductal breast carcinoma in situ (DCIS) could be divided into the same phenotypes. One hundred and eighty DCIS were investigated. Association between the eight variables was studied in 2 x 2 models. The phenotype index was calculated by summing weights for the variables in the MCA. All variables were associated, except Bcl-2. DCIS was divided in two phenotypes. Thirty-three tumours were Phenotype A and 147 Phenotype B. The mean age at diagnosis was 65.5 and 58.4 years for Phenotypes A and B, respectively (p = 0.0012). No difference regarding local relapse free survival was seen. Two phenotypes were distinguished in DCIS, similar to invasive breast cancer. In an earlier study, 45% of the invasive cancers were classified as Phenotype B. In this study, 82% of DCIS were Phenotype B. This may indicate that invasive breast cancer of Phenotype B is derived from DCIS of Phenotype B. The distribution of DCIS phenotypes with a small proportion of Phenotype A DCIS may be due to that Phenotype A DCIS is less likely to be detected by mammography, or that some invasive breast cancers of Phenotype A progress to invasiveness without passing the in situ phase.
- SourceAvailable from: Yuejiao Fu
Article: Effect of quantitative nuclear image features on recurrence of Ductal Carcinoma In Situ (DCIS) of the breast.[Show abstract] [Hide abstract]
ABSTRACT: Nuclear grade has been associated with breast DCIS recurrence and progression to invasive carcinoma; however, our previous study of a cohort of patients with breast DCIS did not find such an association with outcome. Fifty percent of patients had heterogeneous DCIS with more than one nuclear grade. The aim of the current study was to investigate the effect of quantitative nuclear features assessed with digital image analysis on ipsilateral DCIS recurrence. Hematoxylin and eosin stained slides for a cohort of 80 patients with primary breast DCIS were reviewed and two fields with representative grade (or grades) were identified by a Pathologist and simultaneously used for acquisition of digital images for each field. Van Nuys worst nuclear grade was assigned, as was predominant grade, and heterogeneous grading when present. Patients were grouped by heterogeneity of their nuclear grade: Group A: nuclear grade 1 only, nuclear grades 1 and 2, or nuclear grade 2 only (32 patients), Group B: nuclear grades 1, 2 and 3, or nuclear grades 2 and 3 (31 patients), Group 3: nuclear grade 3 only (17 patients). Nuclear fine structure was assessed by software which captured thirty-nine nuclear feature values describing nuclear morphometry, densitometry, and texture. Step-wise forward Cox regressions were performed with previous clinical and pathologic factors, and the new image analysis features. Duplicate measurements were similar for 89.7% to 97.4% of assessed image features. The rate of correct classification of nuclear grading with digital image analysis features was similar in the two fields, and pooled assessment across both fields. In the pooled assessment, a discriminant function with one nuclear morphometric and one texture feature was significantly (p = 0.001) associated with nuclear grading, and provided correct jackknifed classification of a patient's nuclear grade for Group A (78.1%), Group B (48.4%), and Group C (70.6%). The factors significantly associated with DCIS recurrence were those previously found, type of initial presentation (p = 0.03) and amount of parenchymal involvement (p = 0.05), along with the morphometry image feature of ellipticity (p = 0.04). Analysis of nuclear features measured by image cytometry may contribute to the classification and prognosis of breast DCIS patients with more than one nuclear grade.Cancer informatics 02/2008; 6:99-109.
- [Show abstract] [Hide abstract]
ABSTRACT: Systematic synthesis of the published evidence about incidence, risk factors, and management options for women with ductal carcinoma in situ (DCIS) of the breast. Original epidemiologic studies were sought from several databases to identity articles published in English between 1970 and January 31, 2009. Incidence of DCIS in the general population and among women at greater risk of breast cancer and patient outcomes after diagnostic magnetic resonance imaging (MRI) or sentinel lymph node biopsy (SLNB) were abstracted into the developed standardized form. Patient outcomes after breast conserving surgery with or without adjuvant radio- or chemotherapy or after mastectomy were compared from randomized controlled clinical trials (RCTs) and observational studies. Three hundred seventy-four publications were eligible for the review. Rarely diagnosed before 1980, the incidence of DCIS increased by 270 percent since 1987 to 37.5 per 100,000 women in 2001, partially due to increased use of mammography with no good evidence of overdiagnosis (63 publications). Incidence was higher with increasing age, breast density, and family history and lower among physically active women and aspirin users (29 publications). Tamoxifen did not prevent DCIS at longer followup in women at high risk of breast cancer (two RCTs). No good evidence was identified around the optimal use of MRI for treatment planning (64 publications). Case-series from academic centers reported that around 5 percent of women with final histological diagnosis of DCIS had positive sentinel nodes and 1 percent were upgraded to metastatic cancer with no significant differences in outcomes (50 publications). Good evidence from five RCTs (ten publications) suggested that breast conserving surgery with adjuvant radiation reduced ipsilateral (the same breast) tumors by 53 percent with no differences in mortality or contralateral (the second breast) cancer. One RCT demonstrated that adjuvant chemotherapy reduced ipsilateral and contralateral cancer. Ten-year post diagnostic survival was more than 98 percent, while the rates of ipsilateral cancer were around 10 percent (133 publications of 64 observational studies). Major risk factors for ipsilateral cancer were younger age, larger tumor size, comedo necrosis, and positive surgical margins. Limited evidence of worse incidence and advanced outcomes in racial subgroups varied across the studies. Inconsistent evidence suggested that Her2 receptor and negative estrogen receptor status were associated with worse outcomes. No good evidence was found that adjuvant chemotherapy or mastectomy can improve outcomes and there was no evidence on natural history of DCIS or on quality of life among women treated for DCIS. Incidence of DCIS continued to increase with no evidence of overdiagnosis or effective preventive strategies. There is a need to better identify problematic lesions from mammography that are most likely to contain some invasive breast cancer. Most prognostic factors for invasive breast cancer are also prognostic factors for DCIS. The role of MRI and SLNB should be investigated as tools to improve pre-surgical decisonmaking and staging. Breast conserving surgery with adjuvant radiotherapy can benefit all women, though the absolute impact may be small for some women. Ongoing trials will shed light on the optimal clinical strategy for treating DCIS.Evidence report/technology assessment 09/2009;
Article: Heterogeneity Between Ducts of the Same Nuclear Grade Involved by Duct Carcinoma In Situ (DCIS) of the Breast.[Show abstract] [Hide abstract]
ABSTRACT: Nuclear grade of breast DCIS is considered during patient management decision-making although it may have only a modest prognostic association with therapeutic outcome. We hypothesized that visual inspection may miss substantive differences in nuclei classified as having the same nuclear grade. To test this hypothesis, we measured subvisual nuclear features by quantitative image cytometry for nuclei with the same grade, and tested for statistical differences in these features. EXPERIMENTAL DESIGN AND STATISTICAL ANALYSIS: Thirty-nine nuclear digital image features of about 100 nuclei were measured in digital images of H&E stained slides of 81 breast biopsy specimens. One field with at least 5 ducts was evaluated for each patient. We compared features of nuclei with the same grade in multiple ducts of the same patient with ANOVA (or Welch test), and compared features of nuclei with the same grade in two ducts of different patients using 2-sided t-tests (P ≤ 0.05). Also, we compared image features for nuclei in patients with single grade to those with the same grade in patients with multiple grades using t-tests. Statistically significant differences were detected in nuclear features between ducts with the same nuclear grade, both in different ducts of the same patient, and between ducts in different patients with DCIS of more than one grade. Nuclei in ducts visually described as having the same nuclear grade had significantly different subvisual digital image features. These subvisual differences may be considered additional manifestations of heterogeneity over and above differences that can be observed microscopically. This heterogeneity may explain the inconsistency of nuclear grading as a prognostic factor.Cancer informatics 01/2010; 9:209-16.


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1-9 of 9 houses to rent found
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Refurbished semi detached bungalow located in Deganwy with easy access to the A55 and a short walk to local half hourly bus service between Llandudno and Conwy. Cwm Estyn is a small Cul de Sac in a popular sough after area just off Albert Drive. Driveway, detached garage, front and rear garden ... More details ›
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1 bedroom semi-detached house to rent MAES Y COED, Conwy (Town), LL31
A modern semi detached house situated on the outskirts of Deganwy. The accommodation comprises lounge, kitchen, double bedroom with fitted wardrobes, bathroom with over bath bath. The property benefits from a single garage, rear garden with shed and separate front garden. More details ›
Added on 28/08/2014 by Wilsons Lettings, Rhos-On-Sea. Call: 01492 464004 Local call rate
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A three bedroom semi detached home with hills and estuary views. The accommodation comprises; porch, hall, lounge, dining room with feature round window, brick fireplace with inset coal effect gas fire, kitchen with wood clad ceiling, wood clad wall and base units with complementary worktops, sta... More details ›
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2 bedroom house to rent Parc Castell
Unfurnished Immaculate new build semi detached house set in a popluar location, within easy access of the A55 Expressway and onward links. The property provides modern living and the accommodation affords, lounge, dining kitchen, two double bedrooms and modern bathroom with heated towel rail. Two... More details ›
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4 bedroom detached house to rent 5 Coed Y Glyn, Llanrhos, Llandudno LL30 1JL
Four Bedroom Detached House, Separate Kitchen with oven, Lounge and Dining Room, Conservatory, En-suite and Bathroom, Front and Rear Gardens, Garage and off Road Parking, Double Glazing, Gas Central Heating... More details ›
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(Ref.2872) A fine imposing detached 4 bedroomed Edwardian home set in mature landscaped, easy care gardens with patio areas, lawns and two ponds. With the benefit of gas fired central heating and double glazing and offering spacious family accommodation. Situated within an exclusive development ... More details ›
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2 bedroom semi-detached bungalow to rent GWEL Y CASTELL, Llandudno Junction, LL31
Semi detached bungalow on a new development. Lounge, kitchen diner, 2 bedrooms and bathroom. Gas central heating via solar panels, double glazing, off road parking and enclosed, large rear garden. Viewing recommended. More details ›
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2 bedroom terraced house to rent 8 Lon Vardre, Deganwy LL31 9HX
Two Bedroom Unfurnished End Terrace House, Spacious Lounge with Patio Doors leading to easy to maintain Rear garden, Kitchen with Pantry/Storage, Bathroom with shower over Bath, Main Bedroom with built in Wardrobes, Double Glazing, Electric Heating... More details ›
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Unfurnished Delightful two bedroom cottage situated in the popular location of Deganwy. The cottage offers two reception rooms, kitchen, two bedrooms and bathroom with electric shower over bath. Gas central heating and double glazing. Small front garden and rear patio garden. More details ›
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Narrow gauge railway station in Kirov...
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Фотограф: Artem Svetlov Время съемки: 09:46, 21/04/2012 - Views
Narrow gauge railway station in Kirovo-Chepetsk
The World > Europe > Российская Федерация
Karinskaya narrow gauge railway, Tekhnicheskaya station, Karintorf. The only passenger service for Ka...
Karinskaya narrow gauge railway, Tekhnicheskaya station, Karintorf. The only passenger service for Ka...
Расположен в историческом центре г. Кирова на берегу реки Вятки. Действующий. Основан в 1580 году. В ...
Just in case you mistakenly heard that it was all ice and snow in Russia, take a peek at the Big Bikini Exposition. This is right on the river Moskva in Moscow!
Moscow has been the capital of Russia for almost its entire history. The exception is during the period of the Russian Empire, which lasted from 1721 until the Russian Revolution 1917. For these two centuries the capital was St. Petersburg. The Russian Empire was the second largest contiguous Empire in world memory; only the Mongol Empire had been greater.
Check out what's happening north of Mongolia these days, in Chita
Although you may not have heard of Sochi, on the Black Sea, they're building up quickly and hope to host the 2014 Olympics.
Other periods of Russian history include the Tsardom of Russia, from Ivan IV to Peter the Great, and the Grand Duchy (14th-16th centuries).
The earliest period of Russian history was ruled by the Novgorod Republic and Kievan Rus, which was the first Russian state dating back to 800AD in Kiev.
Modern Russia remains one of the world's superpowers. They launched the earth's second satellite, called Sputnik 1, and were the first country to put a human being into orbit around earth. (The first one is called the Moon.)
After the breakup of the Soviet Union in 1991, Russia became a federal republic of 83 states.
Text by Steve Smith.


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Dinosaur Train Buddy w/ Train Car
Based on the new Henson PBS show, the Dinosaur Train collectible segment enables children to collect all of their favorite Dinosaur Train characters, while also expanding their train set. Buddy, a curious, funny, and intelligent T-Rex is the star of the show. This Collectible Train Car Pack includes plastic buddy figure and decorated train car to match! Buddy rides along in the train car which can be attached to the larger Lights and Sounds or Motorized Train for added play!! .
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fax +39 0263632714
Liver Failure/Cirrhosis/Portal Hypertension
Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus–induced cirrhosis. A 12-year prospective follow-up study†
Article first published online: 27 JAN 2010
DOI: 10.1002/hep.23528
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 51, Issue 6, pages 2069–2076, June 2010
Additional Information
How to Cite
Bruno, S., Crosignani, A., Facciotto, C., Rossi, S., Roffi, L., Redaelli, A., de Franchis, R., Almasio, P. L. and Maisonneuve, P. (2010), Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus–induced cirrhosis. A 12-year prospective follow-up study. Hepatology, 51: 2069–2076. doi: 10.1002/hep.23528
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 23 MAY 2010
- Article first published online: 27 JAN 2010
- Accepted manuscript online: 27 JAN 2010 12:00AM EST
- Manuscript Accepted: 8 JAN 2010
- Manuscript Received: 20 NOV 2009
- Abstract
- Article
- References
- Cited By
The incidence of de novo development of esophageal varices (EV) in patients with compensated liver cirrhosis has been determined by few studies in the short term and never in the long term. The aims of the present study were to determine the incidence and the risk factors associated with the development of EV and to assess whether antiviral treatment and achievement of sustained virologic response (SVR) may prevent de novo EV development in patients with HCV-induced cirrhosis. We studied 218 patients with compensated EV-free, HCV-induced cirrhosis consecutively enrolled between 1989 and 1992 at three referral centers in Milan, Italy. Endoscopic surveillance was performed at 3-year intervals according to international guidelines. SVR was defined as undetectable serum HCV-RNA 24 weeks after treatment discontinuation. During a median follow-up of 11.4 years, 149/218 (68%) patients received antiviral treatment and 34 (22.8%) achieved SVR. None of the SVR patients developed EV compared with 22 (31.8%) of the 69 untreated subjects (P < 0.0001) and 45 (39.1%) of the 115 non-SVR patients (P < 0.0001). On multivariate analysis, HCV genotype 1b (hazard ratio [HR] 2.40; 95% confidence interval [CI] 1.17-4.90) and baseline model for end-stage liver disease (MELD) score (HR 1.20; 95% CI 1.07-1.35 for 1 point increase) were independent predictors of EV. Conclusion: In the long term, the achievement of SVR prevents the development of EV in patients with compensated HCV-induced cirrhosis. Therefore, in these patients, endoscopic surveillance can be safely delayed or avoided. Genotype 1b infection and MELD score identify the subset of patients at higher risk of EV development who need tailored endoscopic surveillance. Hepatology 2010
The natural history of patients with compensated liver cirrhosis, induced by hepatitis C virus (HCV) is now well characterized.1-5 However, even if it is well established that the onset of esophageal varices (EV) marks a crucial turning point in the outcome of the disease,6 only one study has assessed the incidence of de novo development of EV prospectively over a short period. However, this study combined patients with alcoholic, HCV-related, hepatitis B virus–related and cryptogenic cirrhosis.7 In addition, the effect of antiviral therapy and the achievement of sustained virologic response (SVR) on EV development has never been evaluated. Finally, apart from the level of the hepatic vein pressure gradient (HVPG), which has recently been shown to be associated with the risk of EV development,7 no other reliable predictor of EV has been described.
The availability of a large prospective cohort study5 that included consecutive patients with compensated HCV-induced cirrhosis followed for up to 18 years allowed us to evaluate the incidence of, the risk factors associated with, and the impact of antiviral treatment, including the effect of SVR, on de novo development of EV in the long term.
Patients and Methods
The present study is a subgroup analysis based on data obtained from a large-scale prospective study aimed at evaluating the long-term outcome of patients with compensated HCV-induced cirrhosis, which has been described elsewhere.5 Briefly, from January 1989 to December 1992, all consecutive patients with compensated Child-Pugh class A cirrhosis who presented at three referral centers in the Milan area (Northern Italy) and tested positive for serum anti-HCV were enrolled. The present study followed the guidelines for subgroup analyses8 and included only subjects who had agreed to undergo upper endoscopy at the time of enrollment (±6 months) and were found to be EV-free.
The Ethics Committees of all participating centers approved the design of the study.
The study includes Child-Pugh class A patients with HCV-related cirrhosis <70 years of age. Patients with bridging fibrosis were excluded. The diagnosis of cirrhosis was based on liver biopsy or on clinical criteria.9 Patients with concurrent hepatitis B or human immunodeficiency virus infection, and patients who were not willing to attend regular follow-up endoscopy were excluded. Patients with previous episodes of decompensation or with hepatocellular carcinoma (HCC) within 6 months from enrollment were also excluded. Anti-HCV was assessed by first- and second-generation enzyme-linked immunosorbent assay. HCV genotype was determined on frozen sera by nested reverse-transcription polymerase chain reaction of HCV core sequences using type-specific primers10 and confirmed on fresh sera by INNO-LiPA (HCVII, Innogenetics, Ghent, Belgium). Information on alcohol intake (>60 g/day for women, >80 g/day for men, for at least 5 years) was obtained during baseline interview and confirmed by relatives.
All patients underwent a 3-month run-in period, and a database including demographic, clinical, laboratory, and endoscopic examinations obtained at entry was set up. Endoscopic procedures for EV assessment were performed in each center by three skilled endoscopists. The size of EV was determined at medium insufflation and classified according to North Italian Endoscopic Club score.11 Child-Pugh score was assessed according to current criteria,12 whereas the MELD score13 was retrospectively calculated using the information collected at baseline. international normalized ratio was calculated by conversion of prothrombin time or activity at baseline.
All patients had a regular follow-up that included clinical, laboratory, and abdominal ultrasound surveillance every 6 months. Examination of the upper gastrointestinal tract was planned at 3-year intervals both for treated and untreated patients, as recommended by international guidelines.14 Esophago-gastro-duodenoscopy (EGD) was also performed at the initiation of antiviral treatment or when clinically required. Additional EGD surveillance after the diagnosis of HCC was not scheduled, unless patients were eligible for surgical resection. At the time of EV detection, beta-blockers were prescribed to patients with medium or large (F2 or F3) varices, while no prophylaxis was scheduled for those with small (F1) varices.
In order to assess the effect of SVR on portal hypertension progression, the measurement of HVPG was also offered to patients who achieved SVR and agreed to perform this procedure. The first HVPG measurement (Time 0) was made 12 months following discontinuation of antiviral treatment and repeated every 3 years (at the same time as EGD). HVPG was measured according to established recommendations.15
Treatment of HCV Infection.
Recombinant interferon (IFN)-α monotherapy or combination with both IFN and ribavirin were offered over time. IFN monotherapy, at the dose of 3 MIU three times a week, was administered, regardless of HCV genotype, for at least 6 months and for an additional 6-month period in patients who achieved a complete biochemical response. Combination therapy with IFN or pegylated IFN and ribavirin was administered in agreement with international guidelines. SVR was defined as undetectable serum HCV-RNA (<50 IU/mL) 6 months after stopping therapy.
Statistical Analysis.
Continuous variables were compared using the Mann-Whitney test. Fisher's exact test and the Mantel-Haenszel chi-square test for trend were used to assess differences in the baseline characteristics between patients who did and did not receive antiviral treatment and between treated patients who did or did not achieve an SVR. Time-to-event was calculated from the date of enrollment to the date of first detection of EV or to the date of last EGD, or death. The cumulative incidence of EV during follow-up was plotted using the Kaplan-Meier method, and the log-rank test was used to assess difference between strata. When specified, observation time was censored at the time of SVR. All patients were included and the time of observation of SVR subjects was censored when successful antiviral treatment was initiated. This choice was justified by the fact that SVR patients were still HCV-RNA–positive in the same way as untreated and non-SVR treated patients until they started antiviral treatment. Univariate and multivariate Cox proportional hazards regression models were used to identify factors associated with EV development. Intercurrent events such as initiation of antiviral therapy, SVR achievement, or HCC occurrence were set as time-dependent covariables. Analyses were performed with SAS version 8.2 (Cary, NC). All statistical tests were two-sided, and P < 0.05 was considered significant.
Among the 352 patients included in the original study,5 26 did not agree to undergo EGD at the time of enrollment, and 54 had EV at baseline. In the remaining 272 patients free of varices at baseline, 54 (19.9%) did not adhere to the endoscopic surveillance program and were thus excluded from the present study (Fig. 1). The baseline characteristics of the 218 patients included in the study, stratified according to antiviral treatment and response to therapy, are shown in Table 1.
|All Patients
|Antiviral Treatment
|P Value
|P Value
|Age, years
|45 (20.6%)
|6 (8.7%)
|39 (26.2%)
|27 (23.5%)
|12 (35.3%)
|31 (14.2%)
|7 (10.1%)
|24 (16.1%)
|18 (15.7%)
|6 (17.7%)
|52 (23.9%)
|12 (17.4%)
|40 (26.9%)
|31 (27.0%)
|9 (26.5%)
|67 (30.7%)
|30 (43.5%)
|37 (24.8%)
|33 (28.7%)
|4 (11.8%)
|23 (10.6%)
|14 (20.3%)
|9 (6.0%)
|6 (5.2%)
|3 (8.8%)
|111 (50.9%)
|30 (43.5%)
|81 (54.4%)
|61 (53.0%)
|20 (58.8%)
|107 (49.1%)
|39 (56.5%)
|68 (45.6%)
|54 (47.0%)
|14 (41.2%)
|HCV genotype
|134 (61.5%)
|38 (55.1%)
|96 (64.4%)
|85 (73.9%)
|11 (32.4%)
|62 (28.4%)
|17 (24.6%)
|45 (30.2%)
|26 (22.6%)
|19 (55.9%)
|22 (10.1%)
|14 (20.3%)
|8 (5.4%)
|4 (3.5%)
|4 (11.8%)
|Alcohol intake
|167 (76.6%)
|49 (71.0%)
|118 (79.2%)
|94 (81.7%)
|24 (70.6%)
|51 (23.4%)
|20 (29.0%)
|31 (20.8%)
|21 (18.3%)
|10 (29.4%)
|MELD score
|85 (39.0%)
|17 (24.6%)
|68 (45.6%)
|52 (45.2%)
|16 (47.1%)
|69 (31.7%)
|23 (33.3%)
|46 (30.9%)
|37 (32.2%)
|9 (26.5%)
|56 (25.7%)
|26 (37.7%)
|30 (20.1%)
|23 (20.0%)
|7 (20.6%)
|8 (3.7%)
|3 (4.4%)
|5 (3.4%)
|3 (2.6%)
|2 (5.9%)
|Median (25%-75% quartiles)
|8 (7-10)
|9 (7-10)
|8 (7-9)
|8 (7-9)
|7 (6-9)
|Alpha-fetoprotein level
|<5 ng/mL
|90 (41.3%)
|31 (44.9%)
|59 (39.6%)
|35 (30.4%)
|24 (70.6%)
|5-10 ng/mL
|73 (33.5%)
|16 (23.2%)
|57 (38.3%)
|50 (43.5%)
|7 (20.6%)
|10-20 ng/mL
|27 (12.4%)
|11 (15.9%)
|16 (10.7%)
|15 (13.0%)
|1 (2.9%)
|>20 ng/mL
|26 (11.9%)
|11 (15.9%)
|15 (10.1%)
|14 (12.2%)
|1 (2.9%)
|2 (0.9%)
|0 (0.0%)
|2 (1.3%)
|1 (0.9%)
|1 (2.9%)
|Median (25%-75% quartiles)
|6 (3-10)
|6 (3-12)
|6 (3-9)
|7 (4-10)
|3 (3-5)
One hundred sixty-three patients (74.8%) had a diagnosis of cirrhosis obtained by way of liver biopsy at the time of inclusion in the study. Half of them were males (50.9%), the majority infected with HCV genotype 1b (61.5%). Approximately one quarter of patients admitted an excess of alcohol consumption during their life. Treated patients were significantly younger, were less likely to be past heavy alcohol drinkers, and had a lower MELD score compared with untreated ones. Among treated patients, only HCV genotype and baseline alpha-fetoprotein serum levels were associated with SVR (Table 1).
Cumulative Incidence of EV.
During a median follow-up of 11.4 years, de novo EV were detected in 67 patients, at the same frequency in untreated 22/69 (31.8%) and treated 45/115 (31.8%) patients. Overall, eight patients developed EV during the first 3 years of follow-up. At the time of detection, the size of EV was small (F1) in 51 (76.1%) patients, medium (F2) in eight (11.9%) patients, and large (F3) in eight (11.9%) patients. Only one of the eight patients with F2 varices but five of the eight patients with F3 varices bled at the time of recognition. The median time between enrollment and detection of F3 varices was 8 years (range, 3-17).
By contrast, no single EV was detected among the 34 patients who achieved SVR (P < 0.0001 versus both untreated and non-SVR patients). Of interest, the median duration of follow-up from enrollment to last EGD was 7.5 years for untreated patients, 10.7 years for non-SVR patients, and 15.9 years for SVR patients (P < 0.0001). Among treated patients, the median duration between initiation of antiviral therapy and last EGD was 8.8 years for non-SVR patients and 12.0 years for SVR patients (P = 0.006). The cumulative incidence of EV among treated patients according to response to therapy is shown in Fig. 2.
During follow-up, 16 of the patients who had developed EV subsequently bled at the same rate in untreated and non-SVR treated subjects (Fig. 1).
Figure 3 provides information on the number of patients, person-years of observations events and the 10-year cumulative incidence of EV in the whole series of patients and stratified according to HCV genotype and MELD score.
Incidence of EV and HCC Development.
During follow-up, 66 patients developed HCC, seven of whom had achieved an SVR (Fig. 1). HCC was diagnosed as a single nodule (<2 cm) in 60% of the cases, and 76% of the patients fulfilled the Milan criteria.19 In 57 cases (86%), patients were free of varices at the last EGD performed before tumor diagnosis. Following HCC diagnosis, EV were detected in 16 patients (in 12 cases within 3 years of tumor occurrence).
Predictors of EV Development.
On univariate analysis, HCV genotype 1b (hazard ratio [HR] 2.38; 95% confidence interval [CI] 1.23-4.59), history of heavy alcohol consumption (HR 2.00; 95% CI 1.16-3.43), elevated serum creatinine (HR 2.41; 95% CI 1.03-5.66), higher MELD score (HR for 1 point increase 1.21; 95% CI 1.08-1.35), alpha-fetoprotein serum leveln ≥10 hg/mL (HR 1.99; 95% CI 1.20-3.29) and occurrence of HCC (HR 2.65; 95% CI 1.45-4.86) were associated with development of de novo EV (Table 2). We found no association with platelets, albumin, international normalized ratio, or bilirubin levels at baseline.
|Baseline Characteristics
|Comparison Groups
|Multivariate 1
|Multivariate 2
|≥55 years versus <55 years
|0.90 (0.55-1.47)
|0.83 (0.48-1.42)
|0.67 (0.38-1.17)
|Male versus female
|1.17 (0.72-1.90)
|0.84 (0.48-1.47)
|0.71 (0.40-1.26)
|1b versus 2a/2c
|2.38 (1.23-4.59)
|2.40 (1.17-4.90)
|2.23 (1.09-4.57)
|Alcohol intake
|Yes versus no
|2.00 (1.16-3.43)
|1.34 (0.74-2.43)
|1.20 (0.65-2.21)
|<80,000/mL versus ≥80,000/mL
|1.72 (0.54-5.53)
|≤3.5 g/dL versus >3.5 g/dL
|1.25 (0.17-9.03)
|International normalized ratio*
|>1.2 versus ≤1.2
|1.61 (0.98-2.63)
|≥1.2 mg/dL versus <1.2 mg/dL
|1.67 (0.91-3.08)
|≥1.2 mg/dL versus <1.2 mg/dL
|2.41 (1.03-5.66)
|MELD score
|1-point increase
|1.21 (1.08-1.35)
|1.20 (1.07-1.35)
|1.25 (1.10-1.41)
|≥10 ng/mL versus <10 ng/mL
|1.99 (1.20-3.29)
|1.61 (0.95-2.74)
|1.45 (0.84-2.49)
|Antibody to hepatitis B core antigen
|+ve versus −ve
|1.35 (0.82-2.20)
|Yes versus no
|1.50 (0.76-2.98)
|Antiviral treatment**
|Yes versus no
|1.02 (0.60-1.72)
|Yes versus no
|No events
|Yes versus no
|2.65 (1.45-4.86)
|2.87 (1.46-5.64)
On multivariate analysis, HCV genotype 1b and baseline MELD score remained independent predictors of EV (Table 2). When intercurrent events were included in the multivariate model, antiviral treatment in absence of SVR did not show any protective effect on EV development (HR 1.02; 95% CI 0.60-1.72). By contrast, HCC occurrence was associated with an HR of 2.87 (95% CI 1.46-5.64) on the development of EV (Table 2). This latter result was not confirmed when the analysis was restricted to the subset of treated patients (Table 3).
|Baseline Characteristics
|Comparison Groups
|Multivariate 1
|Multivariate 2
|≥55 years versus <55 years
|0.79 (0.44-1.43)
|0.64 (0.32-1.27)
|0.57 (0.29-1.15)
|Male versus female
|1.07 (0.59-1.92)
|0.64 (0.31-1.32)
|0.60 (0.29-1.23)
|1b versus 2a/2c
|2.46 (1.03-5.87)
|3.21 (1.28-8.03)
|3.00 (1.19-7.52)
|Alcohol intake
|Yes versus no
|2.10 (1.05-4.21)
|1.56 (0.74-3.27)
|1.61 (0.76-3.41)
|<80,000/mL versus ≥80,000/mL
|0.74 (0.10-5.39)
|≤3.5 g/dL versus >3.5 g/dL
|4.72 (0.61-36.4)
|International normalized ratio*
|>1.2 versus ≤1.2
|1.67 (0.89-3.14)
|≥1.2 mg/dL versus <1.2 mg/dL
|1.63 (0.76-3.53)
|≥1.2 mg/dL versus <1.2 mg/dL
|1.66 (0.59-4.66)
|MELD score
|1-point increase
|1.19 (1.03-1.39)
|1.21 (1.02-1.44)
|1.25 (1.05-1.48)
|≥10 ng/mL versus <10 ng/mL
|1.45 (0.77-2.72)
|1.48 (0.76-2.91)
|1.40 (0.71-2.76)
|Antibody to hepatitis B core antigen
|+ve versus −ve
|1.21 (0.68-2.19)
|Yes versus no
|1.80 (0.82-3.95)
|Yes versus no
|No events
|Yes versus no
|1.60 (0.73-3.52)
|2.07 (0.86-5.00)
When we limited the analysis to F2 or F3 varices (n = 17), a history of heavy alcohol consumption (HR 5.79; 95% CI 1.99-16.8), higher MELD score (HR for 1 point increase 1.27; 95% CI 1.01-1.58), alpha-fetoprotein serum level ≥10 hg/mL (HR 2.92; 95% CI 1.09-7.87), and occurrence of HCC (HR 4.32; 95% CI 1.41-13.2) were associated with development of medium or large varices in univariate analysis, whereas MELD score and development of HCC remained independent predictors of EV on multivariate analysis (data not shown).
In recent years, several studies have described disease outcomes in patients with compensated HCV-induced cirrhosis.1-5 However, although these investigations provide relevant information, none of them report data about the de novo development of EV. In addition, even if there is growing evidence that antiviral treatment may reduce the rate of complications related to portal hypertension when leading to SVR, no study has evaluated whether viral eradication could prevent EV development in the long term.
The present investigation, which fulfills the quality criteria requirements for both observational20 and subgroup analysis studies,8 provides several important data. First, it provides an accurate estimate of the 10-year cumulative incidence of EV in this population of patients. Our figures are lower than those recently reported by Groszmann et al.7 in a 5-year follow-up study. This discrepancy could be easily explained by the different characteristics of patients included in the two studies. In the latter study, more than one third of subjects had nonviral cirrhosis (predominantly alcohol-related), 12% had more advanced disease (Child-Pugh score B), all patients with hepatitis B virus–induced disease did not assume antiviral therapy, and the timing of endoscopic surveillance between studies was different (every 3 years, as suggested by the international guidelines in clinical practice, instead of annually). Moreover, a high proportion of the patients included in the study by Groszmann et al. had a high HVPG (63% had at least 10 mm Hg, with a median of 11 mm Hg). By contrast, the majority of our patients had the diagnosis of cirrhosis made by liver biopsy at the time of enrollment (i.e. at an early, less severe stage of the disease). On the other hand, it is well-established that the stage of compensated cirrhosis is extremely heterogeneous because it includes patients with different but still unrevealed clinical conditions. Moreover, approximately 20% of our patients did not agree to fulfill the planned schedule of endoscopic surveillance and this fact might have led to underestimation of the rate of EV detection.
A major finding of our study—and one of great importance in clinical practice—is that the achievement of SVR abolishes the development of EV in the long term. The reliability of our result is guaranteed by the ample length of observation among this group of patients (median follow-up after initiation of antiviral therapy being 12 years).
The biological plausibility of our result was supported by the finding that HVPG decreased over the years in the four SVR patients who agreed to undergo this procedure and, in all of them, the HVPG values reached the threshold level (<10 mm Hg), which has been reported to be protective for EV development (data not shown). These data are also supported by other studies in which the achievement of virological response following antiviral therapy was associated with a significant decrease of HVPG values,21, 22 fibrosis regression,23, 24 and reduction of portal hypertension–related complications in patients with similar clinical characteristics.25, 26
This study failed to identify a reliable predictor associated with high risk for early EV development. This was due to the low incidence of events in the first 3 years of follow-up. However, we found that a higher MELD score at entry and HCV genotype 1b infection are independent predictors of EV development in the long-term. Whereas the higher risk of EV in patients infected with genotype 1b could be attributable to the low rate of SVR in these patients, the statistically significant association in multivariate analysis suggests that genotype 1b may induce a faster progression of portal hypertension as suggested by a recent meta-analysis.27
Together with an HVPG value ≥10 reported by Groszmann et al.,7 HCV genotype and MELD score may be easily used to identify subjects in whom more frequent, tailored EGD surveillance is warranted.
Another finding emerging from this study is that the risk of EV development increases once HCC has occurred. This result reveals a limitation in our study, however, because frequency of EGD surveillance was performed at 3-year intervals, whereas ultrasound screening for HCC was performed every 6 months. Therefore, we cannot exclude that some patients had developed EV before the emergence of HCC and that the observed rates of EV after the diagnosis of HCC have been overestimated.
In conclusion, the 10-year cumulative incidence of de novo EV in EV-free patients with compensated Child-Pugh class A HCV-induced cirrhosis is fairly low. Despite the presence of established cirrhosis, achievement of SVR after antiviral therapy prevents the development of EV in the long-term. In routine clinical practice, serial surveillance by EGD can be safely delayed or avoided in SVR patients, sparing significant amount of useless invasive and costly procedures. It is conceivable that, as a result of new promising therapies,28 the rate of SVR in patients with chronic hepatitis C will further increase and the burden of portal hypertension-induced complications will decrease over time. Finally, the evidence that genotype 1b infection and higher MELD score increases the risk of EV indicates that tailored, more frequent endoscopic surveillance in this subset of patients may be warranted.
We thank Guido Rainoldi and Felice Cosentino for endoscopic assessment.
- 1Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 1997; 112: 463-472., , , , , , et al.
- 2Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death. Gut 2000; 47: 131-136., , , , , , et al.
- 3Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. Gut 2004; 53: 744-749., , , .
- 4The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients. Hepatology 2006; 43: 1303-1310., , , , , , et al.
- 5Predicting mortality risk in patients with compensated HCV-induced cirrhosis: a long-term prospective study. Am J Gastroenterol 2009; 104: 1147-1158., , , , , , et al.
- 6Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006; 44: 217-231., , .
- 7Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005; 353: 2254-2261., , , , , , et al.
- 8A consumer's guide to subgroup analyses. Ann Intern Med 1992; 116: 78-84., .
- 9Decision-making model for a non-invasive diagnosis of compensated liver cirrhosis. Ital J Gastroenterol 1983; 25: 1-8., , , , , , et al.
- 10Differential distribution of hepatitis C virus genotypes in patients with and without liver function abnormalities. Hepatology 1995; 21: 285-290., , , , , , et al.
- 11
- 12Surgery and portal hypertension. In: ChildCG, ed. The Liver and Portal Hypertension. Philadelphia: Saunders; 1964: 50-64., .
- 13A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-470., , , , , , et al.
- 14Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2005; 43: 167-176..
- 15The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology 2004; 39: 280-282., .
- 16Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 1989; 9: 751-755., , , , , , et al.
- 17The evaluation of fine-needle procedures for the diagnosis of focal liver lesions in cirrhosis. J Hepatol 1994; 20: 117-121., , , , , , et al.
- 18Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001; 35: 421-430., , , , , , et al.
- 19Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693-699., , , , , , et al.
- 20Beyond randomized controlled trials: a critical comparison of trials with nonrandomized studies. Hepatology 2006; 44: 1075-1082., , .
- 21Antiviral therapy decreases hepatic venous pressure gradient in patients with chronic hepatitis C and advanced fibrosis. Am J Gastroenterol 2006; 101: 2269-2274., , , , , , et al.Direct Link:
- 22Effect of sustained viral response on hepatic venous pressure gradient in hepatitis C-related cirrhosis. Clin Gastroenterol Hepatol 2007; 5: 932-937., , , , , , et al.
- 23Eradication of hepatitis C virus in patients successfully treated for chronic hepatitis C. Gastroenterology 2008; 135: 821-829., , , , , , et al.
- 24Brief communication: the relationship of regression of cirrhosis to outcome in chronic hepatitis C. Ann Intern Med 2008; 149: 399-403 [Erratum in: Ann Intern Med 2008;149:844]., , , , , , et al.
- 25Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology 2007; 45: 579-587., , , , , , et al.
- 26Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 2007; 147: 677-684., , , , , , et al.
- 27Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis. J Hepatol 2009; 50: 1142-1154., , , .
- 28Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009; 360: 1827-1838 [Erratum in: N Engl J Med 2009;361:1516]., , , , , , et al.


text:
Dissident Mens Cali T-shirt - Ivory
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Renown for their standout designs, Dissident brings a T-shirt fused with California dreams.
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Tokyo Laundry Mens Shinji Grandad T-shirt
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Axis 21776 Mounting Tool for T91A67 Pole BracketAxis 21776 Mounting Tool for pole mount straps. Tool for tightening steel straps on Axis T91A67 Pole Bracket.
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Michelle Obama
First lady asks leaders to change gender attitudes
Michelle Obama is calling on young African leaders to change longtime "attitudes and beliefs" that harm girls and women. Read more »
Obama maintains busy fundraising schedule, even when crises occur
Last week it was Hollywood glitterati. The week before it was Wall Street financiers. Regardless of what is going on in America and the world, one thing has become... Read more »
Dollars for Obama library roll in from NY, Chicago
The first major donations to President Barack Obama's future presidential library are rolling in from New York and Chicago. Read more »
Letter: Teaching about food
It is entirely possible that children learn to eat the foods they do not like. An understanding of proper nutrition is so lacking in our nation. We need all the help... Read more »
Obama lauds service members at July Fourth picnic
President Barack Obama says the extraordinary sacrifices by U.S. service members are keeping America safe and free. Read more »
Obama encouraging family-friendly work policies
President Barack Obama is encouraging more employers to adopt family-friendly policies by hosting a daylong summit Monday, even though the U.S. government doesn't... Read more »
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text:
Firefighters battle flames at home in Birdsboro
Updated On: Jan 01 2014 05:06:00 PM CST
Firefighters have gotten the upper hand on a fire that destroyed a home in Berks County.
Crews got the call shortly before 10:30 a.m. Wednesday to respond to 330 S. Walnut St. in Birdsboro for the report of a house on fire.
The first pictures from WFMZ's Ryan Hughes on the scene minutes later showed flames shooting through the roof and rising high into the air.
About 60 firefighters representing multiple companies from as far away as Mount Penn were dispatched to the scene. They battled not only the flames and smoke but also ice as water they poured onto the fire quickly froze.
There were no reports of injuries.
The fire was sparked in a rear corner of the home by discarded ashes from a wood stove, said officials, adding that the flames quickly spread from there.
A woman and two children who were inside managed to get out unharmed, said officials, adding that they believe the home to be a total loss.
Images: Fire in Birdsboro
Copyright 2014 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Officials: Fire that destroyed HS football equipment suspicious
Body found in Allentown; death investigated as being 'suspicious'
Man takes car for test drive, doesn't come back, police say
Bucks County teens killed in accident in Wayne County
Police: Child in critical condition after falling from window
Police chief's son allegedly points loaded gun at detectives
Police: Man grazed by bullet in Allentown, refuses treatment
Part of vacant building crumbles; pieces fall on sidewalk
Fire damages house in Bethlehem
Baby whose parents married in NICU comes home


text:
Aug 26, 1942 Total Lunar Eclipse
What this lunar eclipse looks like
The animation shows approximately what the eclipse looks like from the night side of earth.
This is an approximate representation. The eclipse and moon will look slightly different in real life.
This is a total lunar eclipse.
Click the 'play' button to view the animation. The pause button can also be used to temporarily suspend the animation.
Where to see the eclipse
Continents seeing at least some parts of the eclipse:
- Much of Europe
- South/East Asia
- Africa
- South/West North America
- Much of South America
- Pacific
- Atlantic
- Indian Ocean
- Antarctica
Total eclipse visible in:
Locations being able to see at least parts of the Total part.
- Algiers, Algeria
- Dublin, Ireland
- Amsterdam, Netherlands
- New York, New York, U.S.A.
- Athens, Greece
- Brussels, Belgium
- Berlin, Berlin, Germany
- Los Angeles, California, U.S.A.
- Budapest, Hungary
- Mexico City, Federal District, Mexico
- Caracas, Venezuela
- Rome, Italy
- Casablanca, Morocco
- Washington DC, District of Columbia, U.S.A.
- Chicago, Illinois, U.S.A.
- Madrid, Spain
- Detroit, Michigan, U.S.A.
- London, England, United Kingdom
- Buenos Aires, Argentina
- Paris, France
Partial eclipse visible in:
- Moscow, Russia
- Baghdad, Iraq
- Aden, Yemen
- Antananarivo, Madagascar
- Honolulu, Hawaii, U.S.A.
- Aklavik, Northwest Territories, Canada
When the eclipse happens worldwideLunar eclipses look approximately the same all over the world and happen at the same time.
The times displayed might be a minute or two off actual times.
|UTC Time
|Time in Washington DC*
|Visible in Washington DC
|Penumbral Eclipse begins
|Aug 26 at 1:04 AM
|Aug 25 at 9:04 PM
|Partial Eclipse begins
|Aug 26 at 2:03 AM
|Aug 25 at 10:03 PM
|Full Eclipse begins
|Aug 26 at 3:02 AM
|Aug 25 at 11:02 PM
|Maximum Eclipse
|Aug 26 at 3:48 AM
|Aug 25 at 11:48 PM
|Full Eclipse ends
|Aug 26 at 4:34 AM
|Aug 26 at 12:34 AM
|Partial Eclipse ends
|Aug 26 at 5:33 AM
|Aug 26 at 1:33 AM
|Penumbral Eclipse ends
|Aug 26 at 6:32 AM
|Aug 26 at 2:32 AM
* The Moon is above the horizon during this eclipse, so with good weather conditions in Washington DC, the entire eclipse is visible.
Eclipses during year 1942
- Mar 2 – Mar 3, 1942 Total Lunar Eclipse
- Mar 16 – Mar 17, 1942 Partial Solar Eclipse
- Aug 12, 1942 Partial Solar Eclipse
- Aug 26, 1942 Total Lunar Eclipse (Currently shown)
- Sep 10, 1942 Partial Solar Eclipse


text:
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The Zwilling Spirit Collection
Your Size
$39.99 to $89.99
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Reviewed by 1 customer
Best Uses
Comments about Zwilling JA Henckels Spirit Thermolon Dutch Oven with Lid:
great product, pricey but well worth it, it came promptly and it is in use already. If you like
to cook, this is the way to go
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06/18/2014 - Have You Written Your Summer Bucket List?Give your summer bucket list a farm-to-table bend by incorporating a recipe wish list.
06/11/2014 - Fried Eggplant Tapas with Rosemary and HoneyLocal honey plus fresh rosemary plus fried eggplant equals bliss.
06/04/2014 - Peach Vinaigrette for Your Spring GreensBlending two ingredients that don't normally mix well is usually not a great idea—unless, of course, it comes to making vinaigrette.
05/28/2014 - Rhubarbsicle Creamy CocktailsRhubarb is the main event in this cocktail inspired by orange creamsicles.
05/21/2014 - Excuse Our Nerdiness—It's Time to Organize Our PantryStocking the pantry saves time and money—two non-renewable resources—and brings those impromptu food cravings to life.
05/14/2014 - How to Make a Fluffy Omelet … From an Inn Keeper Who Understands EggsWhen it comes to making fluffy omelet—like those served at restaurants when the chefs or cooks know what they're doing—you'll need to master a few techniques to create these airy packages to hold your favorite fillings.
05/07/2014 - Home-Ground Chorizo SlidersEven if you missed celebrating Cinco De Mayo—the Mexican holiday celebrating the Battle of Puebla, where the Mexicans defeated the French in 1862—you can still harness the south-of-the-border flavor with these chorizo sliders.
04/30/2014 - Chimichurri Sauce: No Basil in this "Pesto"As most farmstead chefs know, there's more than one way to make pesto.
04/23/2014 - Herbed Potato NestsThis week marks the annual seasonal potato ritual here at Inn Serendipity: We're planting new potatoes while we eat through the remainder of last year's spuds.
04/16/2014 - Faux Boursin: A Frugal Herbed Cheese SpreadLiving in the heart of Wisconsin cheese country, our cheese purchases fall into two categories: everyday cheeses and Sunday best.
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text:
Weights & Dimensions
|Product Type: Cosmetic bag
|Interior/Lining Material Details: Nylon
|Assembly Required: No
|Exterior Color: Black
|CPSIA or CPSC Compliant: Yes
|General Conformity Certificate: Yes
|Exterior Material: Fabric
|Interior/Lining Material: Fabric
|Number of Items Included: 1
|Hanging: No
|Gender: Mens
|Closure: Zipper
|Foldable: Yes
|Elasticized: Yes
|Lightweight: Yes
|Mirror Included: No
|Tray Included: No
|TSA Approved Lock Included: No
|Wheels: No
|Bottles Included: No
|Commercial Use: Yes
|Country of Manufacture: China
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Terrific traveler
Heather from Chicago, IL– Verified Buyer
When traveling to Europe for two weeks, I needed to be organized. This was super helpful and stored all of my beauty products and electronics.
False Advertising
AJ from Austin, TX
It appeared that you were getting two bags, but in reality you only receive the smaller bag.
OUR SKU # GHB1066This item is also sometimes listed under the following manufacturer numbers: 6411