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San Antonio's Entertainment Source Est. 2005
Monday, July 14, 2014
The Tobin Center Presents Lynyrd Skynyrd Sept. 5th
"Legendary rock band Lynyrd Skynyrd returns with a fiery slice of Southern style guitar rock heaven in Last of a Dyin' Breed, their newest release on Roadrunner/Loud & Proud Records released August 21, 2012. This is the kind of record guaranteed to feed the needs of the multi-generational Skynyrd Nation, and continue the renewed vigor the band exhibited with their last album, 2009's God & Guns."
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The Top 10 In Action Sports
0115 Unbelievably Weird Skate Inventions That You Never Knew You Needed
02Surfers Beware! They're Deadly, They're Lurking In The Water, But You Can't See Them...
03How To Make Your Girlfriend/Boyfriend Hate Your Sport
04Winter Is Coming: The World's Best Snowboarders Are Back - And They're Absolutely Ripping.
05You Might Not Think It, But There Are Some Sweet Waves To Be Found In Jersey...
062014: The Year British Mountain Bikers Showed the World Who's Boss
0719 Signs You're Totally Obsessed With Your GoPro
08These Astonishing Photos Show Sochi Six Months On From The Olympics – And It's A Ghost Town...
09How Would You Like To Surf Perfect Waves Every Three Minutes That You Pre-Booked Online?! Yep, It's About To Become Reality...
10Ski/Snowboard Equipment or Sex Toy: Can You Tell the Difference?
Revolver (Official Trailer)
Revolver, the 2010 film from Poor Boyz Productions, presented by Salomon focuses on the progression and the factors that have coincided with many great advancements of the sport of skiing. (Over the last decade skiing has exploded into what we know it is today. But skiing has had many trying moments long before the end of the 20th century.) This season Poor Boyz Productions plans to showcase todayu2;019s raw talents of skiing in a high action, retrospective, yet progressive look at what things are pushing the sport today.
Simon Dumont, Tim Durtschi, Dane Tudor, Sammy Carlson, Jossi Wells, Charley Ager, JP Auclair, Bene Mayr, Pep Fujas, Andreas Hatveit ,TJ Schiller, Charles Gagnier, Riley Leboe, Matt Walker, Mike Henitiuk, LJ Strenio, Julien Regnier, Josh Stack, Alexis Godbout, John Spriggs, Nick Martini, Brandon Kelly & Leigh Powis
On Location in British Columbia, Alaska, Washington, Oregon, Quebec, Montana, Utah, Colorado, Norway, Austria, Japan, France, Alberta & more
Salomon, Red Bull, Oakley, Giro, Nike 6.0, Atomic, DaKine, K2 Skis, Skullcandy, Pull-In, Kicker, Newschoolers.com, Freeskier Magazine, SBC Skier Magazine

subset: commoncrawl


text: Welcome to the Kardan University to all of our new students and their families! Kardan University president, Roeen Rahmani is an accomplished scholar and innovator whose 10 years at KU have been characterized by vision and a talent for seeing and seizing opportunities. From his creation of a multimedia research center and his energetic tenure as Lecturer, to the pacesetting initiatives he set in motion as KU provost, he has helped propel KU toward its goal of becoming one of the most productive and influential research universities in the world. President Message KU philosophy is based on the fact that we must be a part of the economic development and growth of Afghanistan as well as engage in its rich civic and cultural activities. At a time when the role of the Higher Education Institute is changing dramatically, I believe there is a pressing need for institutions which can engage with the major questions of our time and to understand, articulate and respond to global transformation. KU is distinctively able to do this. Today Kardan University (KU) is the dynamic face of higher education in Afghanistan and the doors of KU are open to students of the whole country, and merit alone is the ticket to join its various degree and diploma programs. KU system of merit, truth, diligence, tolerance and humility has established a culture in which talented students and outstanding teachers have created a community dedicated to quality, innovation and change. KU's standards are demonstratively the highest in Afghanistan and the well-deserved reputation of KU as a premier education institution provides a solid foundation for the future. I foresee a marvelous future for KU that we can achieve together, and I urge all alumni, faculty, students, board members, and friends, of KU to join me in this exciting endeavor. We gladly invite your continued interest in KU and sincerely hope you will consider joining us. Roeen Rahmani Chancellor & PresidentKardan University Kabul Afghanistan


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Will Sprint Corporation Take a Shot at Buying T-Mobile?
There's been much talk lately of an acquisition of T-Mobile by Sprint, but regulators have said such a move would come under very heavy scrutiny. Should Sprint even attempt this?
The top news from the tech sphere for today's Foolish investor.
Telecom Stocks Drop as Sprint Backs Away from T-Mobile
Sprint is said to be reconsidering its plan to acquire T-Mobile. Most telecom shares are lower on the news.
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T-Mobile's (TMUS) aggressive promotions are earning it lots of new customers, but they may not be worth the cost.
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Apple's North American iPhone business could continue to lag as AT&T and T-Mobile demonstrate the popularity of unsubsidized plans.
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Author • Christian Donlan
Pageof 5
Luigi's Mansion: Dark Moon - the Mushroom Kingdom Metroidvania
Mario's brother's back amongst the ghosts, and that's good news for everyone.
Preview 21/01/2013 29
Inside Monaco, the first big indie hit of 2013
Heist society.
Preview 15/01/2013 17
Marvel Heroes preview: Suited and looted
The latest superhero MMO on the scene is channeling Diablo. Excelsior?
Preview 17/12/2012 10
Metro: Last Light preview: The Underground Man
4A's latest promises improvements in terms of the weaponry, the stealth, and the surroundings.
Preview 12/12/2012 25
Rymdkapsel preview: Addicted to base (building)
Prepare to lose lunch breaks to a new strain of "meditative strategy".
Preview 11/12/2012 15
Ace of Spades preview: Driller Killer
Blocks meet bullets in Jagex's team-based first-person shooter.
Preview 10/12/2012 5
Scrolls: from building blocks to building decks
Mojang's follow-up to Minecraft is a very different beast.
Preview 30/11/2012 19
Wii U: How are the ports shaping up?
Donlan checks out the first wave of multi-platform releases, including Mass Effect 3 and Assassin's Creed 3.
Preview 24/09/2012 100
Wii U: Hunting for the star of the launch line-up
Asymmetry and a focus on local multiplayer suggest great promise for Nintendo's new box of tricks.
Preview 19/09/2012 63
The Mighty Quest for Epic Loot: Deadly Rooms of Debt?
Ubisoft Montreal goes free-to-play with this creative blend of construction and destruction.
Preview 11/09/2012 45
Call of Juarez: Gunslinger Preview: Putting The Horse Before The Cartel
The ornery first-person shooter returns to its roots.
Preview 06/09/2012 12
Trials Evolution: Origin of Pain Preview: Yes We Cannon
Hands on with RedLynx's circus of horrors.
Preview 06/09/2012 10
Wildfire Worlds Preview: Occupy Trumpton!
"I was watching the London riots on telly when I suddenly thought: I want to play that."
Preview 03/09/2012 58
WWE 13 Preview: Party like it's 1999
This year's update returns to past glories.
Preview 23/08/2012 27
Skulls of the Shogun Preview: Turn-Based Terror
Hands on with the spooky heir to Advance Wars.
Preview 17/07/2012 10
Game & Wario Preview: Game, Set & Wario?
A quartet of gems suggest that Nintendo's anti-Mario is as much fun as ever.
Preview 09/07/2012 14
Pikmin 3 Preview: Nintendo's Cruellest Series Returns
Red in tooth and claw.
Preview 18/06/2012 17
Project P-100 Preview: Wii U's Secret Weapon
Viewtiful stuff.
Preview 12/06/2012 24
Metro: Last Light Preview: Five Frantic Minutes With THQ's Shooter Sequel
Lights out for the territory.
Preview 29/05/2012 17
Darksiders 2: Death Becomes You
Half an hour with Vigil's new leading man.
Preview 28/05/2012 18
Company of Heroes 2 Preview: Russian Attack
Relic's world-beating RTS turns its attention to the Eastern Front.
Preview 22/05/2012 16
Epic Mickey 2: The Power of Two Preview: Back to the Wasteland
There are plenty of new ideas in Mickey's latest adventure, but is the design team playing it safe?
Preview 13/04/2012 9
Spirit Camera: The Cursed Memoir Preview
Preview 06/04/2012 21
Borderlands 2 Preview: The Right to Bear Arms
Lots of changes to get excited about, but Borderlands is still as gloriously violent as ever.
Preview 05/04/2012 27
The Amazing Spider-Man Preview: Peter Parkour
After years of waiting, Spidey's finally going open-world again.
Preview 14/03/2012 33
MW3 Content Pack 3 Preview: Elite Beat Agents
Picking over the latest of COD's DLC drops.
Preview 12/03/2012 13
Transformers: Fall of Cybertron Preview: Revenge of the Fallen
With Michael Bay out of the way, High Moon is hoping for a return to past glories
Preview 12/03/2012 64
Solitaire Blitz Preview: Why PopCap's Approach to Facebook Gaming is Anything But Casual
Another feather in your PopCap.
Preview 15/02/2012 5
Gunpoint Preview: Rewiring the Action Puzzle Game
How Deus Ex inspired an indie game about electricians.
Preview 31/01/2012 7
Darksiders 2 Preview: Looting the Classics
Vigil digs deep for its Diablo-inspired sequel.
Preview 24/01/2012 23
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How will you know when you find this Kingdom? You know when you find it - for you and Christ are one. You know when you find it - for you are one with friends who love Christ - those who lay down their lives for you.
Do you know that God talks to His people even while they are asleep? Have you recently had a dream that stood out to you in great detail? Dreams can be interpreted by the Holy Spirit so you can fully receive what God is saying to you. Find out what He wants to show you today!
We are commanded to love each other. What exactly does that mean? What does it mean to chosen and appointed? What does it mean to bear fruit?


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The Grouch - Fireflies
Artist: The Grouch
Featuring: Eligh
Producer: Starkey
Album: The Tortoise and the Crow
Avg Rating: 3.5 ( 2 total votes )
Milk and cookies, peanut butter and jelly, The Grouch & Eligh; sometimes the best things come in pairs. Though they don't always work together, Grouch and Eligh have been longtime collaborators and have released their fair share of projects together. Their most recent project, The Tortoise and the Crow, is where their latest video single, Fireflies, originates. Starkey provides the layered, emotional boardwork, which finds Eligh stepping up to the mic first and blessing listeners with his unwavering flow. After a potent hook from guest Steve Knight, Grouch rounds out the record with his crisp approach, helping to keep the momentum going from start to finish. For more dopeness from the duo, grab The Tortoise and the Crow, out now via iTunes.
Listen to More: The Grouch , Eligh , Music Videos, Indie
Written by Lucas G. on 03/13/14
Legendary Music
First DJ Booth Appearance:
"Here I Am" (2009)
Total DJ Booth Features:
12 Songs
Member Reviews and Ratings
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Discover the best new songs, videos, and albums added to the Booth.


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Fox is revisiting the lasagna-loving orange cat Garfield in a sequel to GARFIELD: THE MOVIE, which will be directed by Tim Hill (MUPPETS IN SPACE), reports VARIETY. John Davis will produce through his Davis Ent. label. No word on whether the first film stars Breckin Meyer and Jennifer Love Hewitt will return or whether Bill Murray will again voice the fame fat cat.
Hill was a writer on Nick Films' SPONGEBOB SQUAREPANTS MOVIE and along with Tim Rubiner, created the short-lived Warner Bros. CG TV series GAME OVER.
The original film grossed $75 million domestically and $114 million oversees.


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It turns out we are not the only tourists who've had visa problems.
Waiting in line to file for a new visa, we had the chance to talk to a bunch of people from all over the world. Some were sent the wrong kind of visa, some were allowed into Ethiopia without one but then not allowed to leave, and others like ours expired too early.
Mark and I waited in line for 3 hours and only made it about 1/3 of the way through the visa process. We are headed back tomorrow morning. Keep your fingers crossed.


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Tagged Questions
309 views
What type of fish would be best suited for a trio pairing of sashimi, crudo and ceviche?
I am preparing a trio of fish to exemplify the different ways and methods of preparing fish without cooking it in a traditional manner. The three ways I am preparing said fish will be Sashimi, Crudo, ...


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To perform a search, enter a keyword, phrase or item number in the search field and click "search."
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HORSHAM dog owners and their pets can now earn badges for their efforts as part of Dog Scouts.
Horsham Dog Obedience Club will run Dog Scouts throughout the year.
President Tarni Rees said the club was the second in Victoria to adopt the program.
She said the program originated in America and now Bendigo ran it as well.
Miss Rees said Dog Scouts operated similar to regular Scouts and gave dogs the chance to earn badges.
"We feel that this program will give dog owners new and fun things to try as well as being informative," she said.
She said eight events throughout the year allowed club members and non-members to become involved.
The first event is on February 22 and is for a dog first aid badge.
Other badges include free walking, agility, cafe dog, tracking, improvisation obedience, dog games and dog shaping.
Miss Rees said a trainer would travel from Bendigo for the dog first aid badge event.
"Dogs and handlers will participate in a canine first aid course, with handlers using their own dogs to find heart rates and pulse rates," she said.
"They will also learn to lift and examine their dog. The course is aimed at providing enough
information to the handler so that they do not panic in a situation where their dog might be injured.
"It also aims to provide information useful for stabilising a dog to transport it to the vet."
Miss Rees said each Scout activity would cost club members $10 and non-members $20.
She said a Dog Scout bandana was also available for $10.
Miss Rees said people could visit the club's Facebook page or call her on 0447 745 296 to find out more.
"These activities, while a great deal of fun for dogs and handlers, help handlers appreciate the
connection they have with their dogs," she said.
"These activities provide an opportunity to experience specific canine events but, more importantly, give handlers the encouragement to try something new with their dogs."


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- Melechtric DJ set @ Casa Negra –@6.9.14 wp.me/pGIfH-1rf 6 days ago
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- RT @SauceDJs: Playing @DRMRLLPLS 4th bday this Friday. Check this promo video goodness yeah! youtu.be/Ig3SUbiRppA 1 month ago
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Tag Archives: wafa
Basement Jaxx – Unicorn (WAFA remix)
Our friend WAFA has a new remix out for Basement Jaxx. check it out and buy it on Beatport.
Posted in Big Tunes Tagged basement jaxx, Unicorn, wafa Leave a comment
DRM RLL PLS @ Bugged Out! XOYO with Boys Noize photos!
On Friday night we hosted room 2 at XOYO. DRM RLL PLS DJs Melechtric and Chudmaxx were joined by guest dj WAFA! Check out the photos below:
Posted in chudmaxx, Melechtric Tagged wafa, XOYO Leave a comment
DRM RLL PLS @ XOYO with Plump DJ's and friends..
Tomorrow night (November 12th) we are are hosting room 2 at XOYO alongside Plump DJ's, Hot City, Wafa, CRST and Mista Men. To get you excited for this we thought we'd post up a new mix from Plump DJ's which … Continue reading
Posted in Club Night Tagged CRST, hot city, Mista Men, plump djs, wafa Leave a comment
we have a video…
Filmed by Chris Chudleigh for more scenes like this catch us at Hoxton Square Bar & Kitchen tonight where we'll be spinning all night from 9pm. Free entry.
Posted in Club Night Tagged addicted to you, Count & Sinden, DRM RLL PLS, remix, video, wafa Leave a comment


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Bylsma/coaching discussion thread
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Can you like, shutup
Join Date: Mar 2009
Posts: 4,950
vCash: 500
Originally Posted by
The harsh truth is this: Coaches are hired to be fired, and they usually take an organization like a pendulum. Therrien was hired to introduce structure and discipline. He did it. And, then, like with any other coach, it became too much. Enter Bylsma, to move the pendulum in the other direction. In 2009, he moved it just enough, and the stars were in alignment. Thereafter, he's just kept moving it. A great coach, the guys who stay in jobs for years, recognize when they've swung too much in one direction and can pull it back some. Most can't do that, and the guy who was brilliant just a few years ago becomes wrong for precisely the reasons he once seemed so right. It's just how it works.
I'm sure the same logic would have been used in favor of canning Julien after his team had the biggest collapse in NHL history. Obviously the players had tuned him out, or he had a bunch of coaching flaws that every Bruins fan at the time would have been all too eager to point out.
Coaches being hired to fired is a cliche, one that holds true within certain organizations (perenniel losers, typically) more than it being an unwritten rule in the sports world. If you have a good coach, it's usually a good idea to hang on to him instead of looking to dismiss him every time you hit a rough patch. Especially a younger coach like Bylsma who could be one of the premiere coaches in the league for the next few decades. If the team hits a tailspin like Therrien's did where they look poised to miss the playoffs and everything about the team is depressing that is when you explore a coaching change. You don't panic after a 2-2 start when you've consistently been one of the league's best regular season teams year in and year out.
I'm not sure exactly what it would take for me to want Bylsma fired in terms of good regular seasons followed up by poor postseason performances. Another early exit or two where the entire team falls apart like it did against Philly would get me thinking. I don't consider barely losing with an injury riddled team against a healthy EC contender or losing in 7 games to a goalie who activated god mode before the series to be examples of Bylsma being outcoached. 'Specially not when our playoff hero of a goaltender was handedly outplayed on each occasion.
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Department ProfileSubmit Department
Rockhill Volunteer Fire Department, Inc.
Updated: Monday, November 15, 2004 - 07:28:31 PM
Phone: 540-752-0200
Fax: 540-286-0728
Website: http://departments.firehouse.com/dept/RubyVA
The Rockhill Volunteer Fire Department, Inc. proudly protects approximately 5000 people living in an area of 10 square miles. We operate out of one station that protects a primarily residential area. Our department is a public department whose members are on a volunteer status.
During the hours of 7am and 5pm Monday through Friday our department is supplemented by two to three career Firefighter/Paramedics.
The Career Staff picks up an ambulance from our sister station the Rockhill Volunteer Rescue Squad and brings that unit to the firehouse where they are able to supplement the volunteers at the firehouse.
The Rockhill Volunteer Fire Department was established in 1976. We are located in the north western part of Stafford County. Our run area is bordered to the west by Fauquier County in which we run mutual aid with and to the North across the street from our station we border the training area of Quantico Marine Corps Base. The area that we cover is a rapidly growing residential area with some small business growth. We are a small department with approximately 50 active members.
If you are an authorized department manager for your department's page, and you need to make changes to this department's information, please submit your updates through this form.


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I am a descendant of Fernand Coupet son of Massilly Coupet.
I only can give you a few names, like Leon, Maurice, Luc,
Edouard, Fernand Jr., Georges etc. From what I understand
Massilly coupet came from Martinique.
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Campus Greenhouse Gas Emissions Inventory part of Pedagogy in Action:Library:Campus-Based Learning:Examples
Students conduct a greenhouse gas emission inventory for their college or university. Students analyze findings and present information to the college or university community.
The Modern Atmospheric CO2 Record part of Pedagogy in Action:Library:Teaching with Data:Examples
Students compare carbon dioxide (CO2) data from Mauna Loa Observatory, Barrow (Alaska), and the South Pole over the past 40 years to help them better understand what controls atmospheric CO2.
What Determines Gender in Humans? part of Pedagogy in Action:Library:Interactive Lectures:Examples
In this activity students examine karyotypes from five individuals to try to identify which chromosomes determine gender in humans. This activity is also a good illustration of meiotic non-disjunction.
Simple Mendelian Genetics: An interactive lecture using "DNA from the Beginning" part of Pedagogy in Action:Library:Interactive Lectures:Examples
An interactive lecture that uses flash animations showing the researcher and their experiments that were used to develop the basic concepts in Mendelian genetics. Includes multiple choice questions students can answer in class.
Campus Nitrogen Budget part of Pedagogy in Action:Library:Campus-Based Learning:Examples
Link the college or university operations with local ecology. In this study, students use a tool from urban ecology, the nitrogen budget, to research the inputs, outputs and subsytem transfers of nitrogen on the college or university campus.
JiTT-Scientific Method part of Pedagogy in Action:Library:Just in Time Teaching:Examples
A "Just in Time Teaching" question about he scientific method with follow-up class room activities and an exam question.
Constructing Phylogenetic Trees: The Whippo Story part of Pedagogy in Action:Library:Interactive Lectures:Examples
An interactive lecture in which students use data on feeding habits and habitat, skeletons, and DNA sequences to draw phylogenetic trees.
Human Demographics part of Pedagogy in Action:Library:Mathematical and Statistical Models:Examples
In this biology simulation students explore factors that change human population growth including age at which women begin to bear children, fertility rate and death rate.
Genetic Drift part of Pedagogy in Action:Library:Mathematical and Statistical Models:Examples
In this biology simulation, students use a mathematical simulation of genetic drift to answer questions about the factors that influence this evolutionary process. Students run a series of simulations varying allele frequency and population size and then analyze their data and propose a model to explain their results.
Writing a Wikipedia Genetic Disease Article part of Pedagogy in Action:Library:Teaching with Data:Examples
Writing a Wikipedia article about a genetic disease is a good culminating activity for a genetics course or module, as it requires synthesizing and interpreting a wide range of genetic information. This assignment also includes a potential service component, which is normally very difficult in genetics.
Monohybrid Fruit Fly Crosses: A Simulation part of Pedagogy in Action:Library:Teaching with Data:Examples
This assignment uses a computer simulation of fruit fly genetics to have students design and interpret monohybrid crosses of a trait with simple dominant and recessive alleles. Detailed instructions with animated examples, background material, a sample report and a rubric are included.
Protein Evolution part of Pedagogy in Action:Library:Teaching with Data:Examples
In this activity students explore the evolution of proteins by comparing 2D and 3D alignments of orthologs and paralogs.
Long Term Ecological Resources part of Pedagogy in Action:Library:Teaching with Data:Examples
Students analyze data on temperature and precipitation collected from 26 different Long Term Ecological Research sites and compare them with annual net primary productivity. The students then form an ecological rule to explain their results.
Phenylketonuira part of Pedagogy in Action:Library:Teaching with Data:Examples
In this activity, students are assigned different alleles of the gene for phenylalanine hydroxylase to research using OMIM (Online Mendelian Inheritance in Man). They are then asked to both explain and illustrate how this mutation may cause the disease phenylketonuria (PKU).
Evolution, Natural Selection and Speciation part of Pedagogy in Action:Library:Conceptual Models:Examples
In this out of class tutorial, students explore several examples of natural selection and speciation.
Translation simulation part of Pedagogy in Action:Library:Conceptual Models:Examples
This module introduces students to the basics behind translation of a messenger RNA sequence into protein. In addition to text and movies, there are interactive shockwave animations that allow students to move ribosomes and tRNAs to perform translation.
Daisyworld: Stella Mac or PC part of Pedagogy in Action:Library:Mathematical and Statistical Models:Examples
After constructing a Stella model of Daisyworld students perform guided experiments to explore the behavior of Daisyworld to changes in model parameters and assumptions.
Daisyworld: Interactive On-line PC and Mac part of Pedagogy in Action:Library:Mathematical and Statistical Models:Examples
Students use a JAVA interface design by R.M. MacKay to explore the Daisy World model. The JAVA interface comes with a link to a 6-page student activity page in PDF format.
Searching Genbank part of Pedagogy in Action:Library:Teaching with Data:Examples
An active problem-based assignment that uses the Genbank database to teach the basics of molecular biology and molecular evolution
Plant Pest Control part of Pedagogy in Action:Library:Teaching with Data:Examples
This learning experience introduces participants to scientific inquiry, hypothesis formation, experimental design, data analysis, and interpretation.


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Brad Paisley performs during the Country Music Association (CMA) Music Festival in Nashville, Tennessee June 7, 2012. (REUTERS/Harrison McClary)
NASHVILLE, Tennessee: Country star Brad Paisley will be joining the president and first lady in saluting the military on the Fourth of July at the White House.
Paisley will play the fourth annual "Salute the Military" USO concert for President Barack Obama, Michelle Obama and about 1,200 troops and military families Wednesday night. The performance will be streamed live on the White House website.
Attendees also will be treated to a concert by the U.S. Marine Band, family friendly games and barbecue along with a premium view of the night's fireworks display celebration in Washington, D.C.
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How to Get Lean: 25 Ways to Lose Fat Faster
Not only is it just generally a good idea to get checked out by your doctor on a regular basis, but it's also essential if you want to make sure your body is in peak physical condition for hitting the gym, running, or doing any kind of fitness regimen. It's especially important to have your thyroid checked to make sure you're not suffering from hypothyroidism (or, in layman's terms, an underactive thyroid gland). According to the National Endocrine and Metabolic Diseases Information Service, the thyroid gland controls your body's metabolism. With that in mind, it's essential to ensure that your thyroid is working correctly if you want to lose weight (or avoid possible weight gain). If you're having trouble losing weight (and you're staying active and eating right), you might need to get that thyroid checked out.
Back to the Men's Fitness Nutrition Guide >>>
The #21DayShred: Download the blueprint to building a rock solid, shredded body>>>
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- 10 Best Sources of FiberFiber-filled foods that aid weight loss.
- Perfect 10The hottest NFL cheerleaders of 2014.
- Update Your Hair Products for SummerStock these seven grooming products.


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Recommend: Yes
A wonderful assortment of cards for special occasions with uplifting sentiments. Photography/artwork and wording are perfect.
I think Max Lucado cards will inspire anyone who needs upliftment and encouragement. May Almighty God continue to bless him to continue his work and add much more to his life. Thank you
All inspirational cards are good. These have more hand drawn animals (squirrels, birds, cats) than the front shown card. But overall, they are nice cards.
Appreciate finding these cheerful, affordable cards with Scripture and words of encouragement.
I like this assortment! If you hit the read more button, it tells you that you are getting 4 encouragement cards, 4 blank cards, 4 thank you cards, and 4 cheer cards. These are nice, quality cards that I will be excited to send.
Sign up to receive special offers, devotionals and product discounts from DaySpring.
Sparkle Again: When the Stars Fall Down
I have been hungry for a long time. Soul hungry. I've longed for the cool mist of light spring rain, but I've been wandering in the desert. The desert of […]
7 Good Things…You Can Do with Your Voice
You can pray (Psalm 5:2) You can give thanks (Psalm 18:49) You can sing unto the Lord (Psalm 13:6) You can proclaim the Good News (Mark 16:15) You can feed […]


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PGN is seeking a computer-assisted dispatch record of a vehicle stop initiated by Officer Elizabeth Skala in 2002.
Minutes before the vehicle stop, Skala reportedly gave Morris a three-block Center City "courtesy ride."
Shortly after the ride, Morris was found by a passing motorist with blunt-force trauma to her head at 16th and Walnut streets.
The transwoman died two days later, on Dec. 24, 2002, and her homicide remains unsolved.
The dispatch record sought by PGN could help explain why Skala initiated an unrelated vehicle stop while her Morris assignment was still pending at the 911 call center.
The ensuing confusion contributed to police paperwork that made no mention of the courtesy ride nor Morris' status as an assault victim.
Under the state's Right-to-Know Law, computer-assisted dispatch records — also known as time-response logs — are public documents.
In 2007, the city's Police Advisory Commission gave PGN a computer-assisted dispatch record for Skala's vehicle stop that's missing several lines of entries, and one of its entries has a redaction.
Last year, PGN requested from the Philadelphia District Attorney's Office a complete version of the dispatch record.
Along with the request, the paper provided a copy of the incomplete dispatch record it received from the PAC.
In September, the D.A.'s Office supplied an attestation of non-existence, indicating it didn't have the dispatch record requested by PGN.
PGN appealed in Common Pleas Court, on the basis that the attestation failed to specify the dispatch record the D.A.'s Office denies possessing.
At last week's hearing, Assistant District Attorney Anne B. Taylor acknowledged the attestation referred solely to the incomplete dispatch record supplied by PGN.
Upon hearing this, Judge Nina Wright Padilla suggested that PGN file a new request, clarifying that it's not seeking a copy of the incomplete dispatch record.
The paper filed a new request June 27, containing the clarification. At presstime, the D.A.'s Office hadn't responded.
The D.A.'s Office has verified under penalty of perjury that PGN provided the office a "redacted" dispatch record. But it remains unclear how the office could do so, if it doesn't have an unredacted dispatch record to compare against.
Padilla also must decide whether the state Office of Open Records issued a correct ruling in the matter.
In October, the OOR ruled that the D.A.'s Office met its burden of demonstrating that it doesn't possess "computer-assisted dispatch records for a vehicle stop initiated by Officer Elizabeth Skala."
However, the OOR apparently didn't realize the attestation of non-existence supplied by the D.A.'s Office referred solely to the incomplete dispatch record provided by PGN.
Padilla said she will issue a ruling after reviewing numerous filings in the case.


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Posted Oct 21, 2012By
SAN FRANCISCO—Ryan Vogelsong and the San Francisco Giants saved their season once more, pushing St. Louis to a winner-take-all Game 7 in the NL championship series.
Turns out the defending champion Cardinals aren't the only team that's tough to put away in October.
Vogelsong struck out a career-best nine in another postseason gem, and the Giants held off elimination for a second straight game by beating St. Louis 6-1 on Sunday night.
The Oakland Athletics (78-56) play the Los Angeles Angels (81-53) as they battle for the lead in the AL West. The A
Miami Marlins vs. Los Angeles Angels during a baseball game at Anaheim Stadium in Anaheim, Calif., on Wednesday, Au
Commissioner Bud Selig talks to the media during a press conference about his retirement and state of major league
Miami Marlins vs. Los Angeles Angels during a baseball game at Anaheim Stadium in Anaheim, Calif., on Tuesday, Aug.
Photos from the MLB baseball game between the Oakland Athletics and the Anaheim Angels at O.co Coliseum at O.co Col
The Oakland A's start a crucial three-game series against the Angels at O.co Coliseum in Oakland, Calif. on Frida


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By Melissa Randall
100,000 twinkling lights, dancing to music. It's an annual sight in one Warwick neighborhood, six years running.
The display's creator gave us a sneak peak at what goes into making the elaborate display.
"It's a cross between a rock and roll stage show and an explosion in a bulb factory.", said Frank Picozzi.
If you think it looks cool now, just wait until the lights turn on.
Picozzi's Gristmill Road home in Warwick is undergoing a complete transformation, into what's become a Rhode Island Christmas tradition. "It started as a hobby, but after a while people got wind of it."
The lengthy process to get the display ready is well underway. Picozzi began stringing the lights in mid-October.
"It takes about 250 hours. So I finish probably about a week, week and a half before Thanksgiving."But the process begins much, much earlier. "I have a 25-foot tall Christmas tree in my back yard on 4th of July because I'm practicing the programming on it." Colorful bulbs cover nearly every inch of the front yard. Picozzi carefully checks each one for glitches as he goes...100,000 lights in all.
And running through it all... 3 miles of wire and extension cords.
"Tangled wires are the bane of my existence."
But that's not all. Picozzi programs the music, too, syncing it with the lights and bringing the incredible holiday showcase to life. It's an expensive hobby... "I don't keep track on purpose. I'd really probably be horrified if I knew it."
But it's one the extreme decorate isn't willing to part ways with. The display doubles as a fundraiser for the Make-A-Wish Foundation, and draws in tens of thousands of people each year.
"That's a pretty good legacy to leave for a guy like me."
Picozzi will flip the switch the day after Thanksgiving.
10 Orms Street Providence, R.I. 02904
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Yahoo acquires contextual Android launcher Aviate
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Yahoo acquires contextual Android launcher Aviate 07 Jan
9 Comments
1. InspectorGadget80 (Posts: 6232; Member since: 26 Mar 2011)
How can Yahoo afford to buy a company?
2. HASHTAG (unregistered)
They're still a billion dollar company....
4. elitewolverine (Posts: 1369; Member since: 28 Oct 2013)
just cause google is number one, yahoo has services that google does not.
Buy a car? Yahoo autos not google autos
Buy/rent a house? Yahoo home, not google homes
Their messenger app is still used and not tied to any required social services to use. Their ads and news feed is past googles simplistic web page.
Google is a search engine, yahoo while it does searching (in no bad comparison to google imo), it is also a content feeder on its home page like msn.com is.
5. imMature (Posts: 79; Member since: 04 Sep 2013)
They make ads like Google.. Only a bit smaller.
7. corporateJP (Posts: 1548; Member since: 28 Nov 2009)
LOL...the ads or the company?
3. kaikuheadhunterz (Posts: 692; Member since: 18 Jul 2013)
This is like the first time in months that I have heard the name 'Yahoo'
6. 0o0blackstar0o0 (Posts: 86; Member since: 26 Oct 2011)
What's this "Yahoo" ?
8. corporateJP (Posts: 1548; Member since: 28 Nov 2009)
Wiki it...
9. marbovo (Posts: 621; Member since: 16 May 2013)
I had one website on geocities long ago... bring back memories


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Sneak Preview: The Best and the Brightest Starring Neil Patrick Harris
* Additional fees apply.
All offers for The Best & The Brightest, starring NPH (Sneak Preview and Q&A) have expired.
The last date listed for The Best & The Brightest, starring NPH (Sneak Preview and Q&A) was Tuesday April 12, 2011 / 8:00pm.
Currently at Cinefamily at Silent Movie Theatre:
Movie Screenings at The Cinefamily: Classics, Cult Films and More
- Full Price:
- $12.00
- Our Price:
- $6.00
The Cinefamily is famed for its interesting and unusual screenings of exceptional, distinctive, weird and wonderful movies, often with appearances by special guests or accompanied by live scores. The Cinefamily set out to foster a spirit of community and a sense of discovery in the world of film -- and they continue to come up with new ways to surprise, entertain and delight their loyal audiences. From documentaries, animation and new indie releases to classic sci-fi, monster, midnight movies and way, way beyond, Cinefamily has something for absolutely anyone and everyone. Please see the full event description for details about upcoming scheduled screenings. Learn More
Venue Details
Dinner at Ginghas Cohen for Chinese afterward!Movie Screenings at The Cinefamily info • Mar 07 2013 star this tip starred
Bring a cushion for your back or behind---old, famously uncomfortable seatsMovie Screenings at The Cinefamily info • Feb 05 2013 star this tip starred
Reviews & Ratings
Featured review from Goldstar Member
view more less of this review
The funniest movie of the year (longer really).
THANK YOU GOLDSTAR for providing me with this entertainment opportunity! My husband and I took another couple with us to see the movie and we all could not stop laughing. I'm sure we missed some jokes because we were laughing, so I plan on seeing this funny talkie again!!!
star this review starred report as inappropriate
Good acting by Bonnie Somerville but much of the scenes seemed forced and Neil Patrick Harris seemed uncomfortable and embarrassed to be in this movie. He was totally unbelievable and exhibited no acting chops for his character.
Crude sexuality...continued
star this review starred report as inappropriate
Great little movie theater in the heart of LA run by film lovers. Smart comedy, amazingly well written and acted quite well as well. A lot of clever twists, standout Amy Cedaris, well shot and scored. Much better than 95% of the stuff at...continued
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The movie was truly hilarious - being a fan of Dr. Horrible (hey no smirking - I know there are loads of you out there!), I was hoping NPH would deliver yet another new and unusual bout of comedy to break up the week. It definitely did not...continued
Quotes & Highlights
"Like Ruthless People and A Fish Called Wanda…the kind of adult comedy Hollywood doesn't make anymore." —Movie City News
Visit the film's website.
Watch the trailer for The Best and the Brightest on YouTube.
A cast to die for, an unpredictable plot full of twists, and a nothing-held-back sense of silly, yet intelligent sense of humor—these are just some of the things that make The Best and the Brightest live up to its name. Josh Shelov directs one of the edgiest comedies ever to touch on the rearing of children, featuring Neil Patrick Harris and Bonnie Somerville as a newly-transplanted New York yuppie couple trying in vain to enroll their little girl into an absurdly elitist private kindergarten. After they hire eccentric placement consultant Amy Sedaris, a most outlandish "Three's Company"-meets-the-Farrelly Brothers chain of events tumbles into place. To say any more would be to ruin the film's many surprises, but get stoked for savage swipes at class struggle, as well as some of the most hilarious filthy "poetry" on record. British sensation Peter Serafinowicz, John Hodgman and an outrageously sleazy Christopher McDonald also star in the fiercest farce so far this year. Director/co-writer Josh Shelov, co-writer Michael Jaeger and composer Ted Masur will be on hand for a Q&A after the film on both nights. Co-star Bridget Regan will join them on the 11th, and co-star Bonnie Somerville will join them on the 12th.


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Hide Property Details
- 1 bedrooms
- 1 bathrooms
- Sleeps 2
- Apartment/Condo
Description from the owner
Ka Hale Ola (House of Life) at Wavecrest has every amenity to make our guests comfortable and fabulous unobstructed views of the ocean and the islands beyond. Many of our guests have told us it is the best condo they have ever stayed in anywhere!
The condo is super-clean and features a laptop computer with free internet connection and Microsoft Office Professional installed, large screen TV with cable channels, queen sofa sleeper in the living room, ceiling fans in living room and bedroom, wide selection of CD's, DVD movies, and books, snorkeling and tennis equipment, tropical style furniture, beautiful flooring and bath tile, modern...Read more
Luxury Oceanfront Condo on Molokai
Kaunakakai, Hawaii
What's Nearby:
Additional Location Information
Tropical grounds, condo right on the ocean, very quiet and secluded. Oceanside pool and cabana with library. Tennis courts on the grounds (we provide tennis and snorkel equipment).
More About This Location
Beach or lakeside relaxation, Mountain nearby, Rural retreats, Warm winter getaways, Waterfront
What's Nearby
Tennis courts nearby, Golf course within 30 minute drive, Beachfront property, Fishing nearby
Nearest shops, 13 miles
Nearest beach: 16-Mile Marker, 3 miles
Getting There
Nearest ferry port: Molokai, 13 miles
Nearest airport: MKK, 20 miles
Car is recommended
Rates shown in $ USD
|Minimum Stay
Enter dates to see your price
|Don't see rates for your trip?
Rental fees
- Refundable security deposit | $150 | refunded within 30 days of departure
- Cleaning fee | $85 per stay
- Tax rate | 13.42% of rent
- Fees for additional guests may apply.
Additional notes from the owner
additional nights in low season (more than one week rental) - $125
additional nights in high season (more than one week rental) - $135
- Alarm Clock
- Washing Machine
- Linens Provided
- Ceiling Fans
- Clothes Dryer
- Long term rentals allowed (over 1 month)
- Soap/Shampoo Provided
- Iron
- Housekeeping Optional
- Hair dryer
- Towels Provided
- Short breaks allowed (1-4 days)
- Local Guides/Maps
- Telephone
- Fax Machine
- Internet Access
- Shared outdoor pool (unheated)
- Tennis court (shared)
- Parking
- Private Beach
- Mountain Views
- Ocean or water views
- Grill
- Microwave
- Paper Towels Provided
- Blender
- Refrigerator
- Dishwasher
- Toaster
- Freezer
- Stove or Oven
- Stereo or CD player
- DVD Player
- Television
- Books
- Satellite or cable TV
- Outdoor Dining Area
- Balcony or terrace
- Garden
- 4 Dining chairs
- 4 Lounge chairs
- Pet friendly - no
- Smoking allowed - no
- Suitable for children - no
- Suitable for the elderly - ask
- Wheelchair accessible - no
- 700 square feet
What Past Guests Are Saying
Overall Rating5


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The former United defender recalls his favourite match at Old Trafford...
Both teams went for it right from the off and I scored the first goal of the night. Becks (David Beckham) whipped it in and I was just about to head home when Pally (Gary Pallister) flew over the top of me and headed it against the keeper. By that time I was on the floor. It came back to me and I volleyed it into the roof of the net. It was a great feeling.
Eric (Cantona) scored just before half time, and then Giggsy (Ryan Giggs) and Coley (Andy Cole) made it 4-0. It was a great occasion and we played some breathtaking stuff.
After a game like that it's hard to come down, with the noise of the crowd still buzzing in your ears and your adrenaline still high. When I got home, I watched it on video - and I've since watched it time and again!
It was a job well done and a great night, one of those nights you don't want to end.


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The glasses we ordered are great. Problem is when the shipment arrived, there were no glases but only dinerware. The order was reprocessed and the glasses arrived with 2 out of 6 broken.. The third time was a chrm. they arrived and all was well. The broken glasses were packed poorly. I must say the support all the way through was excellent. The second and third shipments arrived in a couple days.
This was an excellent wedding gift and the young couple who are just starting out really loved them and the design of it.
these glasses are just beautiful! i ordered them as gifts for my bridesmaids and the fleur de lis is kind of our symbol we use in the wedding. it arrived quickly and as soon as i opened the package, i knew that i made the right decision to get these. i think the girls will really love them. thank you very much!! ^^
Usually leaves our warehouse in 1-2 business days. *
Items must be returned in new or unused condition and contain all original materials included with the shipment. More details
FINAL SALE EXCLUSION: Items marked as FINAL SALE are not returnable unless the problem you experience is the result of our error.
Our standard shipping method is ground shipping. We also offer expedited shipping for most items. Your final shipping cost and estimated delivery timeframe will be available at checkout.
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* For your safety, some orders go through our loss prevention department. If we select your order for this process, we will immediately notify you that there may be up to a 3-day delay on your order.
** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.


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Hi, I have a problem with the hidden lines of some profiles.
I have attached an example that shows the error in the Layout called Sheet 1.
There are some profiles with the same position assigned. Some show the hidden lines perfectly, but others do not.
Do you know why?
Thanks in advance.
I test ASD with a simple structure, only 6 beams.
Look at the results at the screenshot! The hidden lines of the two short beams at the bottom are missing.
I made exactly the same steps in each file:
The differences between each file are that I use in:
Any suggestion on how to correct this issue???
Thanks in advance!


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DALLAS -- A jury has been seated for the trial of former Dallas Cowboys player Josh Brent, who's accused of killing a practice squad player in a drunken-driving wreck.
Attorneys selected the jury of Dallas County residents on Friday after two days of questioning. Opening statements in the case are scheduled for Monday.
Brent is charged with intoxication manslaughter in the December 2012 death of Jerry Brown in a fatal crash. Police in the Dallas suburb of Irving say Brent was driving with a blood-alcohol level more than twice the legal limit.
If convicted of intoxication manslaughter or manslaughter, Brent could face 20 years in prison. He could also get probation.
The Houston Texans selected defensive end Jadeveon Clowney first overall in the 2014 NFL Draft.
Round-by-Round Picks: 1 | 2 | 3 | 4 | 5 | 6 | 7
Ray Guy, Derrick Brooks, Walter Jones, Michael Strahan, Andre Reed, and Aeneas Williams, headlined this year's Hall of Fame class. More...
Pro Football Hall of Fame VP of Communications Joe Horrigan joined Game Night with Jim Tatti & Andy McNamara to talk NFL Hall of Fame Weekend
SunMedia NFL Columnist, John Kryk joined Bryan Hayes to discuss the potential of Manziel & EJ Manuel's struggles in camp.
ESPN NFL Analyst, Jim Trotter joined Bryan Hayes to discuss Tony Dungy's comments about Michael Sam, Brett Favre's Packers legacy & Johnny Manziel.


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Green Bay Packers wide receiver Jordy Nelson didn't score but caught eight passes for 93 yards in the Week 3 loss to the Cincinnati Bengals. Nelson was targeted nine times Sunday and was second only to Randall Cobb who had 11 targets. The Packers offense struggled to score points against a tough Bengals defense and Nelson was the leading Packers receiver in the game.
Fantasy impact: The Packers didn't put up big numbers in the passing game and the only receiver to score was James Jones. Nelson led the Packers with 93 receiving yards and will continue to get a ton of looks from Aaron Rodgers. The Packers were decimated at running back after both James Starks and Johnathan Franklin left the game with injuries and the Packers . The Packers have a Week 4 bye and are looking to get healthy. Nelson will return in Week 5 and will remain a must start in all fantasy league.
Keep up with all of our Fantasy Coverage
More fantasy football news from SB Nation:
• Download SB Nation's fantasy football draft guide
• Get live advice daily in the Fantasy War Room


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I'm trying to submit in app with different default language then English in itunes connect but when I try to validate or submit the app via xcode I'm getting this error:
No application records were found. Applications must be ready for upload on iTunes Connect before they can be validated or submitted from within Xcode.
Any of you knows what can I be doing wrong? or how can I fix this error?


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I was traveling to see my daughter in which I haven't seen in over a year and stopped at the Holiday Inn Express for the night. When I pulled up i was very surprised to see how beautiful and well kept this hotel was. I thought it was just built by how well maintained and kept up it was. When... More
- Reservation Options:
- TripAdvisor is proud to partner with Travelocity, Expedia, Booking.com, IHG, Priceline, Agoda, Orbitz, BookIt.com, Tingo, Hotels.com, BookingOdigeoWL, Venere and Otel so you can book your Holiday Inn Express Rawlins reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Express Rawlins Hotel Rawlins
- Holiday Inn Rawlins
- Rawlins Holiday Inn


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Country Singer Tim McGraw Slaps Fan At Concert [VIDEO]
Country singer Tim McGraw recently took exception to a fan that tore his jeans and slapped her while he was performing in concert.
Country singer Tim McGraw recently took exception to a fan that tore his jeans and slapped her while he was performing in concert.
The Today show weatherman Al Roker took his daughter and her best friend to a Drake concert. Pretty typical for a Dad to take their daughters to concerts when they're only 14-years-old. The show was in Hartford, Connecticut on Oct. 26. One of the funniest Vines I've seen in a while. Its pretty cool that Al Roker Vined himself. I'll give him credit for that.
Ladies, try to contain yourselves when we tell you that the New Kids On The Block have announced that they will not only be coming out with a new album, but they are also going on tour with boy bands 98 Degrees and Boys II Men. The tour titled, "The Package Tour," starts on May 31st in Ucasaville, CT.
Justin Bieber will be in concert next Tuesday, January 15th, in New Orleans at the New Orleans Arena and we want to send you to the concert!!! Yes, we said YOU, not us, but YOU to New Orleans to see JUSTIN BIEBER!!
Hot 107.9 wants you to find your Wiz. No ... seriously .... your 'Wiz' will be in public bathrooms all around Acadiana, and we want you to find it! If you do, you'll be seeing Wiz Khalifa LIVE in New Orleans!
Rihanna and Chris Brown are at it again.
Smack dab in the middle of Furgate, that controversy magnet Lady Gaga resumed wearing meat, fashioning a corset-like outfit out of what looked like a slab of beef. It's a familiar, uh, fabric, for Mother Monster. She rocked the attire onstage in Bucharest, Romania last week. Maybe the meat went bed or smelled rancid, as she she also promptly vomited, mid-performance.
Jay-Z's star-studded Made in America music festival reportedly will get the big-screen treatment. The rap mogul has teamed up with ad executive Steve Stoute, producer Brian Grazer and director Ron Howard to create a concert film about the festival, which takes place in Philadelphia on Sept. 1 and 2.
Eminem has been through plenty of ups and downs in his career and most of it was well-documented in the media. From his bitter divorce with his ex-wife, Kimberly Scott, to his bout with drug addiction, his life was an open book. During his surprise set at the G-Shock 30th Anniversary event in New York, Em thanked his fans for their support.
The American Idol Live! Tour made a stop in Lafayette, LA yesterday and put on one heck of a show in front of a sold-out Cajundome crowd! American Idol winner Phillip Phillips rocked the stage. Idol runner-up Jessica Sanchez serenaded south Louisiana with her smooth vocals, along with great performances from all of the Idol finalists.


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I love that when Chef John Placko of the Modern Culinary Academy (the guy who has dined at El Bulli in Spain and Noma in Denmark – read his impressive bio here) comes to work with Les Petits Chefs that he thinks big. Like me, John believes that with the right kind of guidance, kids can […]
Les Petits Chefs make rhubarb in textures with John Placko
Les Petits Chefs make steamed buns with Vanessa Yeung
Last week was Vanessa Yeung's SIXTH visit to work with Les Petits Chefs (see below for a list of all the other dishes she's made with them) and despite the fact that she's KNOWN for her dumplings, this time she deviated slightly in her menu, offering the boys a chance to learn how to make […]
Les Petits Chefs search for "Nutrition in the Aisles"
No cooking for the Petits Chefs this week (but we have some very exciting guests coming to work with the boys for the final two sessions of the year – stay tuned!) because we tried something a little different – a food-related field trip! I was really interested to learn that the Field Trip Factory […]
Getting kids excited about food for Food Revolution Day!
Jamie Oliver knows how to get kids excited about food. The official Food Revolution Day recipes this year prove that. There are so many great looking dishes that I had a hard time choosing what to make with the boys this week in both Les Petits Chefs and Cooking Basics blubs as a nod to […]
Les Petits Chefs make pizza from scratch with Massimo Bruno
Massimo Bruno is a bit of legend amongst the Petits Chefs alum – to the point where a bunch of them paused in their tracks the other day when they realised that Massimo was "in the house" and making pizza. I saw more than a few wistful looks from boys who are no longer in […]
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|All Over 30
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|Short review: Older femmes have been called everything from MILFs to cougars to sultry old harlots, but these females are a force to be reckoned with once they hit their intimate first-class. All Over 30 fetes the sexuality of experienced ladies and hand picks their top-models to insure only the most raunchy older femmes. This web-site has a strict "no scanks allowed" policy, so you wont find any trashy hoors or old biker oldies. All of these experienced ladies are smart and sexually adventuresome females who look absolutely sexy as they get older.


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« Oxford's New Building, One Year Later |
| Honesty, Of A Sort »
Posted by Derek
It's been a busy day on the front lines of science around here; apologies for not getting anything up until now. Here's a topic that I was discussing with some colleagues not too long ago: how much do we need to know about each other's specialties, anyway? I'm assuming that the answer is "more than nothing", although if someone wants to make the zilch case, I'd be interested in hearing it done.
But once past that, what's the optimum? I (for example) have never done cell culture. Nor do I see myself ever needing to do it (and anyone who needs me to is clearly in a bad way). I know the broad outlines of the field, but almost none of the details, and I'm sure that even my broad outlines have some faint parts in them. So if I'm at some sort of meeting where the problem-of-the-day turns on cell culture issues, I can be of no help at all. Is this a problem? I understand that different cells take to culture conditions differently, have varying growth rates, need media changes and whatnot, can generally only be passaged a certain number of times, etc. In short, I know roughly what to expect from my cell culture colleagues, and what would be silly of me to demand. Is that about right?
After all, I don't expect them to know the ins and outs of medicinal chemistry, particularly the synthetic organic lab part of it. Things like methylene chloride being rather more weirdly polar as a solvent than you'd expect, or the fact that some amines will stick to solid magnesium sulfate drying agent (but not sodium sulfate), or how you can azeotrope out acetic acid with toluene, or how you want palladium tetrakis to be lemon yellow and not orange - these and dozens of others are the tricks of my lab trade, and they don't know mine in the same way that I don't know theirs.
But I do like it when my biology colleagues have the broad outlines - that molecules with chiral centers, other things being equal, are often harder to make than achiral structures, that sticking a lot of cycloalkyl grease on a molecule is asking for metabolic trouble (no matter what it does for the potency in the assays), what sorts of things tend to make a molecule more (or less) soluble, and so on. Those are the equivalent of me knowing that primary cell lines lose some of their functions in culture, the difference between transient transfection and a stable cell line, etc.
It seems to me that each discipline in our business could draw up a list of What Everyone Else In the Company Should Know about their area. So, to start off with, I'm throwing the comments section over to what biologists (and others) should know, at a minimum, about med-chem. Take it away!
Comments (43)
+ TrackBacks (0) | Category: Life in the Drug Labs
1. goldilocks on January 19, 2010 1:53 PM writes...
ChemDraw structures are two dimensional representations of three dimensional structures... and bonds can rotate. Seems like something the biologists should know, and yet so many of them seem to forget.
2. PharmaHeretic on January 19, 2010 2:03 PM writes...
Usually 3rd year organic chemistry (undergrad) is enough, IF they had understood the material. I do not claim to understand 200 reactions, but can follow the logic behind a well written synthetic scheme and have a rough idea about what it can and cannot do- substitution wise.
I suggest carefully rereading an undergrad organic chemistry textbook, and using scifinder to see what others have done.
3. Ed on January 19, 2010 2:40 PM writes...
Hey! Cycloalkyl grease is what we're all about at our shop - preferably with a hydroxamic acid attached!
4. Anonymous on January 19, 2010 2:53 PM writes...
You may find this paper interesting for the purpose of this post.
5. qetzal on January 19, 2010 2:56 PM writes...
PharmaHeretic -
By "3rd year organic chemistry" you mean the two semesters of OChem that a biol major would typically take during their 3rd (junior) year, right? Cause if we biologists need 3 years of OChem to understand What Everyone Should Know about med chem, we're doomed!
6. Phillip Chase on January 19, 2010 3:37 PM writes...
OK, here's some things straight off the top of my head to move things along:
Know if they use up all the material, they understand how long it may take to make more.
Potency is usually the easiest parameter to optimize; all the others (permeability, metabolic stability, toxicity, solubility, crystallinity, etc.) are increasingly difficult to modulate in concert with the others, and sometimes by themselves.
Precision for the in vitro assays is more important than accuracy when you're looking for the effects of structural variation.
Don't worry about asking for more compound to do critical experiments; making the compounds should not be the limiting factor in progressing the project (although it many times is).
Know the difference between enaniomers, diastereomers, and what a straight racemic line in ChemDraw means in relation to a front or back (up or down) line.
That there are issues of scale when making 20 g of something you've only made in a 30 mg amount once.
Understand what types of functional groups impart what types of effects, e.g. polar for solubility, H-bonding, etc.
Understand the concept of conformational restriction and why it can impart a positive or negative effect on activity.
Understand where diversity is useful and where it is not. This is critical when assay throughput and turnaround or chemistry productivity comes up, so it's a productive conversation instead of one group automatically taking up a defensive position.
That sometimes doing med chem is just trying out a lot of different ideas, with what appears to be and many times is randomness; if it was that easy to design a drug from scratch, we wouldn't need hundreds of us in a company to do it.
Understand the concept of isosteric replacements.
Understand the difference between sterics and electronics.
Know what x-ray structural info and computational chem can provide.
Understand that we usually can't tell a priori what level of solubility a compound is going to have in a DMSO/buffer system.
Understand that we usually have more ideas than we can synthesize and must use experience, knowledge, logic, colleagues, and even management to try to triage down to the best and practical ones.
Sometimes the "obvious" compounds to make turn out to be incredibly difficult to synthesize.
Understand the concept of patentable space and why some leads are not followed further.
Understand the concept of flat SAR.
Back to work; hopefully more to come...
7. JK on January 19, 2010 3:41 PM writes...
Dear Phillip
Just make the damn cmpds and shut up. please.
8. PharmaHeretic on January 19, 2010 4:00 PM writes...
Yes, I am talking about organic chemistry as taught to a biochem-type major. However, most universities do a poor job of teaching the material and high school does not prepare students for university.
I would suggest reading, and understanding, an undergrad-level organic chemistry textbook.
9. CVL on January 19, 2010 5:11 PM writes...
I am with qetzal and Phil on this topic. I've feel that I probably did learn that 1 year of ochem and I feel that my university did a pretty decent job of teaching it to me. But even then, there are clear gaps in my knowledge. Somethings I probably should know like the differences between chiral and achiral chemistry. But I have no clue how sticking on specific functional groups are related to the permeability. Just like in cell culture, most of these things aren't taught but rather they are picked up from years of experience. No textbook tells you that MCF7 cells grow faster than CHO cells and no textbook should.
10. Simon on January 19, 2010 7:53 PM writes...
Just want to chime in and let you know that your problem is not limited to medicinal chemistry, or even biology.
Us telecommunications designers have the same problem. Shall we have lunch? ;-)
(Yes, that's right, I only have high school chemistry - my training is in electronics & software - but I'm fascinated by hard science & tech in general so I do read this blog).
11. barry on January 19, 2010 8:35 PM writes...
recognizing that the gram of drug substance that has been used for milling/formulation studies can usually be repurifed far faster than another half gram can be synthesized would be a welcome leap in sophistication.
12. anon on January 19, 2010 9:54 PM writes...
Jeffrey Kindler - is that you?
13. Old-Timey on January 19, 2010 10:07 PM writes...
Can we include the computational chemists in with the "non-chemists"? I recently had to explain atropisomerism to a PhD computer-jock chemist.
14. Old BioChemist on January 19, 2010 10:40 PM writes...
It is clear that both sides have some learning to do. In my experience, having open, collaborative, interdisciplinary project discussions enlighten all involved and make better scientists. It takes time to understand the limitations of each discipline.
15. anon the II on January 19, 2010 11:19 PM writes...
Old-Timey, I confess.
I've made them, I can assign their configuration using the Cahn-Prelog-Ingold rules and I've known about them since reading Eliel's book 33 years ago, but I still had to look up atropisomers to remind myself just what the term meant.
16. Curt Fischer on January 20, 2010 2:35 AM writes...
A good follow-up to this post is the converse: what do medicinal chemists know about, say, cell culture? I'd start off, but I'm not a medicinal chemist.
17. London Chemist on January 20, 2010 3:20 AM writes...
Two things I have trouble explaining to biologists (or they have trouble understanding?):
1)The difference between kinetic and thermodynamic solubility, and why in house synthesised batches are less soluble than the 2mgs bought from ACME chemicals...
2) How much custom syntheses cost. If Sigma sells stuff for less than GBP100 (USD160), how come 50mg of that active cpd from the lit with 3 chiral centres costs over GBP10K (USD16k)....
18. DrSnowboard on January 20, 2010 4:43 AM writes...
"That sometimes doing med chem is just trying out a lot of different ideas, with what appears to be and many times is randomness; if it was that easy to design a drug from scratch, we wouldn't need hundreds of us in a company to do it."
Stone the heretic, he doth blaspheme the gods of rational drug design. Stone him.
19. Jon-ster on January 20, 2010 6:42 AM writes...
Off-topic...but I find that cyclohexane is a much better azeotrope for acetic acid than toluene, and the azetrope distills at lower temperature. Just one to keep in mind!
20. Mark on January 20, 2010 7:37 AM writes...
As a pharmacologist, it's been very helpful to understand that gram scale material doesn't just appear overnight, and that formulating for in vivo studies can be tricky as well.
Conversely, chemists should understand the inherent imprecision with biological assays. As the saw goes, physics goes to five decimal points, chemistry to the decimal point, and biologists are lucky to get the sign right
21. anchor on January 20, 2010 8:13 AM writes...
My experience is that it is easier for medicinal chemist (starting of as organic chemist) to become biologist, rather than other way around. In my group meetings I always found constructive suggestions on biology coming from medicinal/organic chemist. To me the organic chemistry is like math in that you know good math then you can be great physicst.
22. biochem belle on January 20, 2010 8:38 AM writes...
From someone who is somewhere between biology and chemistry...
Biologists don't have to understand all the chemistry required to make a compound but should be able to follow enough to know where substitutions can be made most readily. This might be as much an issue of communication b/t med chemists and biologists as it is biologists not understanding chemistry.
Biologists should know what functional groups are bad news from the standpoint of solubility and metabolism and why certain substitutions (like chloro- for methyl) are made.
23. kate on January 20, 2010 8:53 AM writes...
An interesting point that we have recently been discussing too! There was a good paper recently in Drug Discovery Today, from the chemists at Vernalis in the UK, who have clearly decided that enough is enough and have educated their biologists...
24. HappyDog on January 20, 2010 9:16 AM writes...
#13 Old-Timey
Please realize that there is a great diversity in the backgrounds of computational chemists / molecular modelers. There was a joke at one company I worked at that none of us were qualified for our jobs because no one had a degree in computational chemistry. Most comp. chemists actually have backgrounds in a different field such as medicinal chemistry, biology, biochemistry, computer science, mathematics, physics, pharmacology, etc. So I am not necessarily surprised that you could stump an individual comp. chemist with a question like that, but on the other hand, I've known very good comp. chemists with many years of med. chem. experience before they stepped out of a lab who have a really good idea about what compounds are synthetically accessible. They might not be good protein modelers however, but we have other computational chemists that do that well. Most of us are good at scripting (Perl, Python, C-shell, etc.), but aren't good programmers. On the other hand, there are very good programmers who don't understand cheminformatics . . . The point is that our field is actually a pretty diverse one.
I have one request for something chemists should know about chemistry. Namely, tautomers, resonance structures, and protonation states.
25. goldilocks on January 20, 2010 9:22 AM writes...
As #16 said, there are things that chemists should know, too... anyone want to volunteer?
26. E on January 20, 2010 11:54 AM writes...
To Anonymous #4, many thanks for posting a link to the Drug Discovery paper! I've now sent that paper to all of my colleagues (12) in my regulatory toxicology department and have already had a lot of them say it was just what they'd been looking for without success.
27. HappyDog on January 20, 2010 11:56 AM writes...
Could I make a comment about what med. chemists should teach us comp. chemists?
1) What chemistries are obviously disallowed. Examples include connections through O-O bonds and reactive groups like Michael acceptors. There's a list of chemotypes most med. chemists won't touch. It would be extremely useful to distill it down for us.
2) The key synthetic steps for a chemical series in a given program, as well as common chemical reactions in the company and the industry as a whol


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5 days straight of rock climbing. Starting to feel the effects today
Finally getting to go climbing a lot more often , getting rid of that couch potato feeling from all this work feels great.
Anonymous said: I'm sorry about your picture, that sucks!
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I've had a shitty day, my 4x5ft print that was hung in the national photographic archive fell 10 feet to the ground and almost killed someone, so glad no one was hurt but my print is no more :( .
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The undrafted Poapst, you may recall (but you're forgiven if you don't), played 25 games for the Caps back during the 1995-96 and 1998-99 seasons, registering a single goal and no assists. He'd go on to play 282 games for the Blackhawks, Penguins and Blues, wrapping up his career with a 41 game stint in St. Loo in which he had an assist and a minus-21 rating.
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Strong virtues & a good example work miracles as a parent, too.
That is what I strive for as a mother for my daughter's future's sake and to help lift my husband up to achieve that goal for our sons' futures.
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Bump cops 1521/ ChiefDC501!
We have stories of officers getting milk for babies, this stuff only serves to diminish the professionalism and good efforts of the LE during this whole tumultuous ordeal..
I liken this article too experiencing awesome sex with someone new, and then randomly blurt out the fact that they have a booger in their nose!
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Come on, any story that quotes anything from "Info Wars" is best described by the latin word CRAPOLA! That group of nut jobs has numerous time been fronted out as having STAGED, EDITED and PHOTO SHOPPED this stuff for years to promte the agendas they stand for. And shame on you for post a bogus story like this here!
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I actually know someone who has a daughter taht lives where this happened. She stated that the LEOs who came to her house were very polite and ASKED if they could come in to check to make sure the suspect wasn't in there. She felt she could have said no, but had no problem with letting them in so she said yes. When they were done, they thanked her and left. She felt very safe knowing they were there.


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Richard Alexander Roehrl
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First Name: Richard
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Rescued pit bull pup saves boy's life
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It didn't take TaterTot long to earn a special place in the hearts of a Minneapolis family. Just days after Christi Smith brought the 10-month-old pit bull home as a foster, he detected a life-threatening drop in her son's blood sugar level.
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Radical Film Night & Vegan Potluck-Film: A.L.F. Behind The Mask
Wednesday, Jan 9, 2013 7:00p
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What better way to celebrate the new year than with a vegan potluck & Animal Liberation Front film Behind the Mask: The Story Of The People Who Risk Everything To Save Animals
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Time is DEFINITELY not on your side.
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Time is DEFINITELY not on your side.
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Finish reading 9 Problems That Weren't Solved by Advice Columns
Why It Motivates You: Not all motivators have to be negative. If our country's ongoing obesity epidemic is any indicator, the prospect of having something tasty to munch on is one of the best way to get us up off our fat asses. Think about it. If you smelled bacon cooking from the next room over, would you ignore it? Of course not. You'd drop what you were doing and immediately go investigate it because that's human nature.
How It Works: Though most of us aren't lucky enough to have someone wake us up with the smell of sizzling bacon wafting from the kitchen, we are lucky enough to live in a golden age of food laziness, and have easy access to technologies that can easily approximate such a lovely scene. Using food delivery services like Seamless as a template, the food alarm would have you floating out of bed like you're a cartoon dog that's just gotten a whiff of a pie. Just place your order and the time you want to get up, and the next morning, a delivery man will greet you with a bag full of deliciousness, instantly transforming you into a morning person.
Finish reading —> 5 Alarm Clocks That Would Totally Motivate You to Get Up
Freshman-O-Vision - Things look a little different when you're a freshman
Even more Drunk-O-Visions & Porn-O-Visions
Colleges will always have freshmen, and freshmen will always find increasingly stupid ways to embarrass the rest of the campus. It's the circle of collegiate life. As such, we've put together a series of predictions to help you better prepare yourself for this academic onslaught of inexperience.
Finish reading —> 8 Freshman Predictions We Really Hope Don't Come True For You
Da Vinci's 'Vitruvian Man' Goes To College
Go to CollegeHumor.com for funny, new original videos and articles everyday.
College is a time filled with decisions. What to major in, whether or not to join a frat and, most importantly, how to arrange the beds in your dorm room. Once you unpack all your stuff it's really annoying to move them again. Here are the pros and cons for the seven most common dorm-bed configurations.
Finish reading —> The Anatomy of a Dorm Room
Finish reading What Everyone is Bringing to Your Freshman Hall
Go to CollegeHumor.com for funny, new original videos and articles everyday.


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It's back to school today for more than 130,000 students.
Classes start Sept. 2 at all San Diego Unified schools.
A lot goes into preparing schools worthy of our students. Watch our Operations Services Division in action
Included here is some important information parents should know heading into the 2014-15 school year