text: Biology 30 – Big Bad Chart of Endocrine Hormones Name: ________________________ Date: ___________________ Complete the missing information for each hormone below. Mechanism of action refers to how the hormone acts at the cellular/ molecular level in the target cell. Be specific. Hormone Endocrine Stimulus for release Target and mechanism of Diseases and Disorders Gland (Where action (effect) is it produced?) TSH Anterior low levels of Target: thyroid gland TSH deficiency leads to pituitary thyroid hormones Effect: stimulates the thyroid decreased thyroid hormones – can (T4 and T3) gland to secrete T4 (thyroxine) be life threatening hypothalamus and T3 to increase metabolism releases TRF (Thyrotropin Releasing Factor) to stimulate TSH release by pituitary FSH - female Anterior negative feedback Target: follicle Lack of GnRH or FSH will pituitary from estrogen and Effect: stimulates the follicle lead to infertility/ patient progesterone to grow and secrete estrogen not maturing into puberty, positive feedback etc. – headache, visual from estrogen disturbances, mid-cycle hypogonadism hypothalamic increased FSH can lead to release of GnRH ovarian failure (Gonadotropin Releasing Hormone) FSH – male Anterior negative Target: Seminiferous tubules lack of GnRH or FSH will pituitary feedback from and Sertoli cells lead to infertility/ patient inhibin (released Effect: production of sperm not maturing into puberty, from testes) – and inhibin in the testes etc. – headache, visual inhibits FSH disturbances, release! hypogonadism stimulation by hypothalamic release of GnRH LH – female Anterior negative Target: Ovary; corpus luteum tumour, infection, pituitary feedback from Effect: stimulates ovulation in inflammation or injury estrogen and females mid-cycle (day 14); lack of GnRH or FSH will progesterone stimulates the corpus luteum to lead to infertility/ patient positive produce hormones (E + P) not maturing into puberty, feedback from post-ovulation etc. – headache, visual estrogen mid- disturbances, cycle hypogonadism hypothalamic release of GnRH (Gonadotropin Releasing Hormone) LH (ICSH) – Anterior negative Target: Interstitial cells of the tumour, infection, male pituitary feedback from testes inflammation or injury high levels of Effect: stimulates the lack of GnRH or FSH will testosterone production of testosterone lead to infertility/ patient hypothalamic not maturing into puberty, release of GnRH etc. – headache, visual (Gonadotropin disturbances, Releasing hypogonadism Hormone) Hormone Where is it Stimulus for release Target and mechanism of Diseases and Disorders produced? action Glucagon Pancreas (alpha low blood sugar Target: too high glucagon = cells) Liver hypoglycemia too low glucagon = Effect: hyperglycemia Converts glycogen into glucose; increases blood sugar levels Cortisol Adrenal Cortex ACTH (anterior Target: Adrenal Insufficiency pituitary) Liver (Addison's Disease) – lack of Effect: cortisol (and aldosterone) Stress Promotes the conversion of from adrenal gland – autoimmune – chronic amino acids into glucose; fatigue, muscle weakness, increases blood glucose loss of appetite, weight loss, ↓ levels BP (fainting, etc.), can lead to death because of severe electrolyte imbalance (within days) prolonged/ chronic stress – high levels of cortisol – heart damage, ↑ BP, diabetes, early death hGH Sleep, exercise Target: Body cells too little hGH in childhood = (somatotropin) Hypothalamus: Effect: Regulates cell division, dwarfism – small stature, no releasing growth of long bones and problems with mental or hormone muscles sexual development too much hGH in childhood = gigantism – tall stature, long arms and legs too much hGH in adulthood = acromegaly – bones can no longer increase in length so bones and soft tissues widen – enlarged feet, hands, coarse (masculine) facial features, other physical problems like enlarged heart, liver, kidneys, etc. Testosterone Testes Lutenizing Hormone Target: Entire body Decreased testosterone: (interstitial (LH) from the Effect: Stimulates the decreased libido, impotence, cells) anterior pituitary development of the male regression of secondary sex reproductive tract and characteristics (growth and secondary sex characteristics maturation of penis + scrotum, distribution of hair, increased muscle mass, etc.), fatigue, loss of energy, etc. increased testosterone (i.e., steroid abuse) – 'roid rage, shrinking testicles, low sperm count, loss of body hair, man-boobs, etc. Hormone Where is it Stimulus for release Target and mechanism of Diseases and Disorders produced? action Oxytocin Hypothalamus Child labour: Target: uterus Deficiency rarely causes and stored in pressure on the mammary glands clinical problems the posterior cervix Effect: smooth muscle pituitary Breastfeeding contractions of the uterus; (suckling action release of milk from the of infant) mammary glands Progesterone Ovary (corpus LH Target: Uterus Infertility luteum) Effect: causes thickening and vascularization of the endometrium; prevents uterine contractions Estrogen Ovaries FSH stimulates Target: entire body low estrogen levels can lead (follicles or follicles to release Effect: stimulates the to irregular periods or corpus luteum) estrogen (pre- development of the female amenorrhea, infertility, ovulation) reproductive tract and female decreased libido, etc. – LH stimulates the secondary sex characteristics replace estrogen will pills or corpus luteum to patch (HRT = hormone stimulates the lining of the release E + P post- replacement therapy) uterus ovulation menopause = decreased estrogen levels, end of menstrual cycles, hot flashes, rising cholesterol, decreased bone mass, ↑ risk of heart disease and some cancers high estrogen – menstrual irregularities Thyroxine Thyroid gland TRF from the Target: Body cells low thyroxine in childhood = hypothalamus Effect: Controls the rate of cretinism – short stature, TSH from the cellular respiration overweight, metal anterior pituitary (metabolism); plays an developmental delays important role in the growth low thyroxine as adults = and development of children Hypothyroidism – slow pulse, puffy skin, weight gain, hair loss, slow metabolism, cold intolerance, sluggish thought processes Graves' disease = Hyperthyroidism (in adulthood) – body's immune system attacks thyroid gland – anxiety, insomnia, heat intolerance, irregular heartbeat, weight loss, exopthalmus can remove part of thyroid gland or treat with meds lack of iodine = goitre swollen thyroid gland – TSH still stimulates thyroid but it cannot make T3/T4 so swells up (Rx: add iodine to diet – salt, canned goods, etc.) Calcitonin Thyroid gland high blood calcium Target: Bones, kidneys and lack of calcitonin may levels intestines contribute to osteoporosis Effect: bones absorb calcium (linked to estrogen decline in from bloodstream; decreased post-menopausal women, but absorption of calcium in the men can get osteoporosis too) intestines and kidneys Hormone Where is it Stimulus for release Target and mechanism of Diseases and Disorders produced? action PTH Parathyroid Low blood calcium Target: Bones, kidneys and high PTH can lead to (Parathyroid glands levels intestines osteoporosis - risk of hormone) Effect: Breakdown of bones to fractures, compression of release calcium into the blood; spine, etc. reabsorption of calcium in the low PTH also means low vit. kidney; increased absorption of D, which can lead to rickets (improper bone formation, calcium from intestine bow legs, etc.) low PTH can also result in muscle contracture Epinephrine Adrenal gland Nervous system Target: lungs, heart, blood adrenal gland tumour can lead (Adrenaline) (medulla) Stress vessels, liver, pupils to ↑ nor/ epinephrine Effect: increased breathing production = rate; increased heart rate; pheochromocytoma – increased blood pressure; increased HR, high appetite but no weight gain, heart increased conversion of palpitations, nausea + glycogen into glucose; pupils vomiting, etc. – treatment: dilate surgery = remove tumour Aldosterone Adrenal gland Target: Kidney Adrenal Insufficiency (cortex) Effect: Stimulates the nephron (Addison's Disease) – lack to increase the absorption of of cortisol (and aldosterone) sodium, increasing the blood from adrenal gland – pressure autoimmune – chronic fatigue, muscle weakness, loss of appetite, weight loss, ↓ BP (fainting, etc.), can lead to death because of severe electrolyte imbalance (within days) Hormone Where is it Stimulus for release Target and mechanism of Diseases and Disorders produced? action Insulin Pancreas (beta high blood sugar Target: body cells and liver decreased insulin = diabetes cells) levels (e.g. after Effect: body cells become mellitus – high blood a meal) more permeable to glucose; glucose levels liver converts glucose to (hyperglycemia) glycogen. As a result blood IDDM (insulin-dependent) – glucose levels decrease Type 1 – (juvenile diabetes) pancreas can't produce insulin, must take insulin shots to live cells cannot use glucose for energy therefore must turn to other energy sources, such as fat and protein, thus body breaks down stored fat (ketoacidosis is the smell of acetone, a fat breakdown product, on the breath) and will lose weight as fat/ protein (muscle mass) broken down - increased urination (volume and frequency), sugar in blood and urine, dehydrated, tired, thirsty, etc. has many complications in the body, including neuropathy (neurons degenerate), blindness, kidney failure, may result in limb amputation, etc. - new treatments: islet cell transplants, stem cells non-IDDM (non-insulin- dependent) – Type 2 – (adult onset) due to autoimmune or cells not responding to insulin - must be controlled with diet, exercise, oral drugs called sulfonamides - obesity predisposes you to non-IDDM - insulin shots do not work as treatment - same S&S gestational diabetes – occurs in pregnancy (rare 2-4%) too low insulin = hypoglycaemia Hormone Where is it Stimulus for release Target and mechanism of Diseases and Disorders produced? action Prostaglandins act on cells cell damage Target: Most body cells menstrual cramps: that produce prostaglandins released from them in Effect: uterine muscle contractions response to stimulate inflammation at the during menstruation – may cell damage damage site, increase blood flow, be relieved by aspirin stimulate platelets to form clots in (blocks enzymes involved in damaged blood vessels, fever, prostaglandin production) pain perception ADH Produced in the dehydration/ Target: Kidneys – distal diabetes insipidus lack of (Antidiuretic Hypothalamus increased tubule and collecting ducts ADH – person produces Hormone) Stored and osmolarity of LARGE volumes of dilute secreted from blood (blood too Effect: Increases permeability urine (normal= 2 L; disease the posterior concentrated – of nephron to water – more = 20-25 L), becomes dehydrated (loses ions from pituitary high ion/mineral water reabsorbed back into blood too) – treatment: content) bloodstream – body excretes replace ADH (nasal spray, less (but more concentrated) tablet, injection) urine, BP increases (effect on blood vessels = vasoconstriction) Prolactin Anterior inhibited by high Target: mammary glands tumour can lead to milk pituitary levels of E + P Effect: stimulates milk production in females that are production not mothers = prolactinoma during irregular menstrual periods or pregnancy amenorrhea, milky discharge after giving from breasts, but still fertile birth, the mother (can ovulate) – can also occur produces and in MEN! (suppresses LH and FSH therefore they lose their secretes sex drive, masculinity, become prolactin infertile, etc.) ACTH Anterior negative Target: Adrenal cortex excess ACTH production pituitary feedback from leads to increased cortisol high levels of Effect: stimulates the adrenal levels – a disease called adrenal cortex cortex to secrete Cushing's Syndrome hormones glucocorticoids (cortisol) and (weight gain, moon face, hypothalamic mineralcorticoids (aldosterone) "buffalo hump" on back release of CRF of neck, excess hair (Corticotropin growth, loss of muscle Releasing mass, infertility, etc.) Factor) stimulate ACTH release


text: Celebrities Who Talk Beauty on Twitter! by Jamie Roy 21/2/12 0 Reactions 0 Shares Print 0 0 0 0 0 It's not just you and me who tweet to the world about their favourite beauty finds. Nope, celebrities do it too. Of course it's questionable if they are getting paid to do it, or if they are just sharing their opinions, considering that Kim Kardashian and Soulja Boy get paid up to £6,000 per tweet (hard to believe, isn't it)? I'll let you be the judge. Check out these five tweets from Lady GaGa, Paloma Faith, Louise Roe, Victoria Beckham and Cheryl Cole and let me know if you think they're pimping something out, or if they're simply just showing their love. Cheryl Cole Tweets About Her Lipstick What's Your Reaction? 0 0 0 0 0 0 On January 27th, Cheryl Cole tweeted, "Have you tried my L'Oreal lipstick for my Charity with the Princes Trust? Not only is it for charity but it is Gorgeous!! I LOVE it! You can get it here ... 1 / 5 Paloma Faith Tweets About Her Hair What's Your Reaction? 0 0 0 0 0 0 On December 1st, Paloma Faith tweeted, "Has anyone tried superdust by L'oreal? Its so bloody good? Instant BIG HAIR!" How fun does this product sound. Does she make you want to run out and buy it? 2 / 5 Louise Roe Tweets About Her Manicure What's Your Reaction? 0 0 0 0 0 0 Louise Roe tweeted this cool photo of her newspaper-print manicure in New York City over the weekend. She said, "My server @Bloomingdales' nails, she painted, dipped them in rum & held newspaper on them" — how fun! 3 / 5 Lady Gaga Bleaches Her Own Hair....At Her Own Risk! What's Your Reaction? 0 0 0 0 0 0 On January 10th, Lady Gaga tweeted, "Bleaching my hair! Scalp burning like a champ. A real blond loves a #PeroxideShot." Ouch — no one ever said looking beautiful was easy! 4 / 5 Victoria Beckham Tweets About Skincare Brand Caudalie What's Your Reaction? 0 0 0 0 0 0 Victoria Beckham recently tweeted "Caudalie from Paris gives u a 'glowing complexion' use it on top of your make up. x vb" 6 / 5 0 0 0 0 0 Back to Homepage Comments Read More Louise RoePaloma FaithLady GaGaTwitterBellaCelebrity BeautyVictoria BeckhamCheryl Cole

subset: commoncrawl


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Will Angus T. Jones remain on 'Two and a Half Men'?
CBS chief Les Moonves makes first public comments regarding YouTube attack
When asked if the non-apology apology offered by "Two and a Half Men" star Angus. T Jones last week sufficed to keep him on the show, CBS chief Les Moonves said: "I don't know what our status is with him."
Bing: More about Les Moonves | 'Two and a Half Men'
The cold remark was made at a breakfast Q&A conducted by the Wall Street Journal on Tuesday, and reported by Forbes.
Wait. So the head of a network, when making a preplanned appearance before the media, claims not to be on top of the biggest news story involving his network? Does anyone else smell fish? More likely, Moonves is aware of Jones' status yet not prepared to publicly announce what it is. (Jones' character was already shipped off to the Army at the end of last season, so it wouldn't be too much of a stretch to either leave him there or -- as they did to Sheen's character -- kill him off.)
In a YouTube video last week, Jones referred to "Two and a Half Men" as "filth" and urged fans to stop watching.
Moonves continued, seeming to convey genuine contempt for Jones: "It seems to be what happens with child stars over time. We took this boy, who started with us when he was eight-years old. Now's he's making over $300,000 per week, which is not a bad salary for a 19-year-old kid. By the way, he's still collecting his $300,000 per week."
Yes, but for how much longer?
"I don't think it's been quite resolved," Moonves said. "But after going through what we went through with Charlie Sheen, it's been a piece of cake."
In other words, being publicly attacked only hurts half as much coming from half a man.
"Two and a Half Men" airs Mondays at 8:30 p.m. ET/PT on CBS.


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...sounds like the name of an old vaudeville comedy team.
In any case, it seems that Ray Lewis and Terrell Owens have been taking pot shots at eachother through the media. This should make Friday night's exhibition game rather interesting, not to mention the week 8 meeting of these teams in the regular season.
I've posted the full article below. Some quotes are in bold; I added that emphasis.
"http://www.courierpostonline.com/news/sports/s081704a.htm" wrote:
[size=18px]Owens, Lewis trade verbal barbs prior to showdown[/size]
Associated Press
[size=9px]Terrell Owens said Monday that he expects the Ravens to take shots at him in Friday night's exhibition game.
Tuesday, August 17, 2004
By DON BENEVENTO
Courier-Post Staff
PHILADELPHIA [/size]
Long before the teams were to meet in a preseason football game at Lincoln Financial Field on Friday night, the Eagles and the Baltimore Ravens were adversaries in a contentious struggle - for the rights to obtain Pro Bowl receiver Terrell Owens.
It's was quite a battle, and it's still going strong - at least based on the war of words that emerged Monday from both teams' headquarters.
"Tell T.O. to keep my name out of his mouth," Baltimore Pro Bowl linebacker Ray Lewis told reporters in the Ravens' locker room. "I don't care nothing about this guy."
Back in Philadelphia, Owens was acknowledging that the Ravens might be inclined to take some shots at him Friday night. But he also said he would have the chance to take a few shots of his own.
"In the running game, I might be able to return the favor," Owens said.
It's quite a build-up to a preseason game.
The first battle between the teams was for the rights to Owens. The Eagles eventually won, sending defensive end Brandon Whiting to the 49ers and a fifth-round pick to the Ravens in exchange for Owens.
But the issue was decided only after the NFL worked out a compromise that nullified a trade of Owens to the Ravens.
End of story, right?
If other members of the Ravens organization were willing to live without Owens, Lewis was not. Lewis said this spring that he is not happy that Owens was able to get out of the Ravens trade. Plus, he suggested he would put his feelings into a more physical form when the teams met on the field.
"He's going to have to meet me on the field sometime," Lewis said at the time. "I have no respect for guys who pose and things like that."
Owens has gotten the message.
"I heard it, I processed it, and it is what it is," Owens said Monday. "For whatever reasons, he's (Lewis) upset."
Owens also knows that he just may have to be a little extra careful.
"Everybody knows that Ray is a high energy guy, and he's going to play that way and talk that way," Owens said. "He plays the same whether it's the Pro Bowl or the regular season. He plays hard and I play that way as well."
Asked if he thought there was a chance some of the Ravens defenders may try to come after him, Owens acknowledged that it was a possibility.
"They may," he said. "But this is a situation where we're going to play football. There may be a situation where they may have some shots at me, but in the running game, I might be able to return the favor."
Talking with reporters in Baltimore, Lewis said, "Sooner or later, no matter how much he talks about what he's not scared to do, he still has to line up and play football."
Lewis and Ravens safety Ed Reed also noted that Owens had just three catches for 23 yards when the Ravens beat Owens' San Francisco team by a 44-6 score last season.
"T.O. is a nobody," Reed said Monday, according to CBS Sportsline.com. "He's nothing."
Friday's game, the first of two meetings between the teams - the other coming on Oct. 31 during the regular season - serves as a reminder of the intense battle for Owens' services the Eagles and the Ravens waged during the offseason.
Both teams had power advocates presenting their cases in Hawaii for Pro Bowl last February. Quarterback Donovan McNabb spoke for the Eagles while Lewis presented the Ravens' side.
"We were both out there doing appearances and doing things for the league, so we had opportunities to talk," McNabb said. "But everyone was communicating at that time. Ray had been talking to him, Peyton Manning had been talking to him.
"It wasn't like we were recruiting . . That's pretty much something we have no hand in. But Ray was working him. It's funny what I'm hearing - the back and forth between the two - but everything was cool then."
In fact, Owens said he still considers Lewis a friend.
"I have no grudges against Ray," he said. "I'm not sure how he feels about me, but as far as I'm concerned he's my friend. There's nothing there. This just came out of nowhere. It got into a war of words. . . . I'm hoping this is the last time we have to revisit this. I just want to play ball. There are reasons why I'm here and not there."
For one thing, Owens has been groomed in the West Coast offense, and he wanted to go to a team that played that style. He also wanted a chance to play with McNabb.
"I know that Kyle Boller is not a bad quarterback but he's an up-and-coming quarterback that I'm not really familiar with," Owens said of the Ravens' starter.
Owens also said he believed he could be the last element that could get the Eagles into the Super Bowl.
"It's an opportunity of a lifetime," Owens said. "I think this team has been the verge of getting to the big show, and I felt I could be the last piece of the pie."


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Country Classic Show
If any one performer personified the outlaw country movement of the '70's, it was Waylon Jennings. Listen Sunday, June 5th at 11:00 AM to the the Classic Country Spotlight featuring Waylon Jennings.
If any one performer personified the outlaw country movement of the '70's, it was Waylon Jennings. Listen Sunday, June 5th at 11:00 AM to the the Classic Country Spotlight featuring Waylon Jennings.
Foley High Students drove their tractors to school this morning for their Annual Tractor Day. We were there to capture all the fun on video and a few surprises along the way!
The Oak Ridge Boys are celebrating their 30th anniversary of "Elvira", the song that made them famous. They'll be performing at the Winstock Country Music Festival this summer and the Paramount Theatre in St. Cloud this winter. Listen Sunday to hear the music of the Legends of Country Music on the 98 Country Spotlight at 11:00 AM.
We all celebrate Memorial Day every year. We have our parties, we have our fun and we travel to our lake houses. But what should we be doing on Memorial Day? I asked myself that question and found the answer.
Classic country star Glen Campbell performed at the Paramount Theatre in Downtown St. Cloud Tuesday. If you missed Glen's performance at the Paramount, we will review his music on the 98 Country Classic Spotlight at 11:00 am Sunday May 22nd.
Relive the music of Vern Gosdin Sunday May 15th on the Country Music Spotlight at 11:00 am on the Country Classic Show. Nicknamed "The Voice" he had 19 Top Ten Solo Hits on the Country Music Chart from the late 1970's through the early 1990's.
The kids are counting down the days until they have a break from school but what happens to everything they have learned this year over the summer? Some will retain portions of it, others, like me, will forget most of what they learned and will end up struggling in the first few weeks of next school year. A recent study shows that American kids are behind much of the world in learning and some propose sending the kids to school year round.
Ricky Van Shelton married Betty Witt in 1986. Van Shelton has also written and published a series of children books, called "Tales from a Duck named Quaker." Sunday May 8th we will play the music of Ricky Van Shelton on the 98 Country Classic Spotlight at 11:00 am. It's all apart of the 98 Country Classic Show Sunday's from 9 am to 1 pm.
I went to bed early last night and missed the interruption in broadcast networks from President Obama announcing that after 10 years of searching for Osama Bin Laden, the search ended with the killing of the most dangerous terrorist in the world. Watch the President's address and give us your reaction to the news.
Tornadoes ripped through my home state of Alabama and have left millions without power and supplies and thousands without homes. These storms were unlike anything I have ever seen as I tracked them for my family as they were ripping through the state. Check out the photos and learn how you can help those that are left with nothing.
Every time a new Iphone product comes out, the lines form with thousands of people lining up to get their hands on it the day it hits stores. I have always known the Iphone and Ipad were too good to be true. It turns out Apple is secretly monitoring your every move and recording every place you go. Sounds scary right? But it's true!
Janie Fricke was a popular female Country singer in the 1980's. She won the Country Music Associations Female Vocalists of the year award in 1982 and 1983. She racked up an enviable roster of hits with a flair for ballads. Fricke's breakout year was 1981, when she scored two top ten hits. Join me Easter Sunday April 24th when we look back at the music of Janie Fricke 11:00 AM, 98.1 FM St. Cloud's Country Music station.


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- From murgh biryani to McChicken
July 13, 2013
Daryaganj, on the cusp of old and new Delhi, is changing - it is now no longer just the home of tandoori and korma. Over this summer, fast food…
- Cover your hairs, shameless
July 13, 2013
She changed her picture on Twitter. And the abuse began to flow.
- Minute to burn it
July 13, 2013
Bored by long workouts? Just seven fast and furious minutes can produce results.
- In This Section
- Entire Website
From the Times Of India
Jobs in Detroit's car factories are moving to India.
Chidanand Rajghatta
Can 'bindaas' or 'jhakaas' survive transliteration?
Shobhaa De
India's first superstar died almost a lonely life.
Robin Roy
Black humour
The Tamil film industry's obsession with fair skin extends to the script, comic routines, and even the insults.
It was supposed to be an evening of fun and family entertainment. But halfway through the screening of the latest Tamil movie Singam 2, the heated exchange between the hero and villain had Bangalore-based lawyer Sindhu Shankar sitting up in her seat. When the villain, played by British actor of Ghanaian origin Danny Sapani, badmouths the Indian police, the heroic cop played by Suriya mouths the unmistakably racist slur, "African korangu", or monkey.
Shankar stared in horror as more such insults followed. The baddy is giving Suriya grief in South Africa too. In rage Suriya lets loose an enraged volley in which he calls Danny 'Afrikan mirugam (African animal)'. It isn't just the poor villain who is the butt of racist slurs. A sidekick who is very dark and sports sandal paste across his forehead gets it too. The man runs a teashop where a grimy boiler, also sporting three auspicious lines of sandalwood paste, is puffing away. Says Susai, the comedian played by Santhanam: "Kariyerrina boilerile chandana pottu vachirikke (You have drawn three lines of sandalwood paste across the blackened boiler). " "What?" asks the belligerent sidekick. "I didn't mean your face, I meant the boiler, " says Santhanam. But the the audience at the upmarket multiplex didn't seem bothered. "I am a Suriya fan and his movies are good family entertainers, but this was really offensive and nobody seemed to realise it, " she says.
The makers seem to have got the message enough to remove the offensive dialogue for the international audience after an adverse reaction. "We removed it for screenings abroad as we got a call from a friend saying it was unnecessary. We never wanted to hurt anyone. Our aim is only to entertain, " says filmmaker G Hari, who directed the film and its hit prequel. The Hindi version of Singam, starring Ajay Devgn, collected more than Rs 100 crore, and it is a foregone conclusion that this too will be remade.
As the chief aim is to entertain the 'mass' crowd at any cost, makers of blockbusters are only too eager to reinforce stereotypes and prejudices. "They use all tactics to get the audience on the side of the hero. In this case, the guys in the theatre are sure to applaud the scene. It is unfortunate that in the process we forget that we are offending sensibilities, " says Anu Hasan, Tamil actor and TV personality.
As for playing up dominant prejudices, directors and writers don't have to look far in Tamil Nadu. Though racism is still far away, the fixation with skin tone provides some easy laughs and stereotypes. "When a child is born, one of the first things asked in Tamil Nadu is the colour of the skin. Matrimonial sections are full of ads for fair women, " says film writer Theodore Bhaskaran. He says the colour fixation has a caste overtone with dark skin associated with lower caste people.
The filmmakers have found it useful to use this skin tone fixation while writing comedy tracks. The comedy stars of the 1990s, Senthil and Goundamani, have exhausted all the names in the animal planetinvariably suffixed with a 'karuppu' (black).
"The only person who could laugh about it and still be positive was superstar Rajinikanth, " says Kavitha Emmanuel, founder of Women of Worth network, which also has a 'Dark Is Beautiful' campaign. In Sivaji (2007), Rajini goes through various whitening beauty treatments so that the heroine accepts him. "He makes fun of the obsession with fair skin and asks the girl what the connection between skin colour and marriage is, " says Emmanuel.
According to actor and film historian Mohan Raman, the fair skin fixation is such that dark-skinned people were not shown on screen till the '70s. Or, if they were, the actors were covered in layers of pancake. The heroines get an additional dose of body makeup and are further 'lightened'.
Villains with relatively fair skin are also preferred in the industry. The only people who are 'acceptable' with darker skin tones are the evil guy's henchmen. And this trend was faithfully copied by the makers of Chennai Express as showcased in the movie's first set of posters. In them, Shah Rukh Khan and Deepika Padukone were flanked by half-naked men in lungis. "What do you expect from an SRK movie?" says Shankar, referring to Deepika's exaggerated 'Madrasi' accent in the trailer of Chennai Express and Shah Rukh's cringe-worthy portrayal of a curlyhaired Tamilian in Ra. One.
But that doesn't mean that viewers are past caring. "One would think that popular heroes and big directors are aware of what they are showing on screen. It doesn't hurt to be a little more responsible, " says Shankar.
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Docker is an Open Source engine to build, run, and manage Linux Containers. Containers use less resources than virtual machines, they boot faster, but they have similar guarantees of portability and repeatability for Linux applications. Those features made Docker and Linux Containers extremely popular for development and testing environments. But what does it take to use Docker and Containers for production workloads?
In this talk, we will present how to solve elegantly some complex deployment challenges, including:
The audience doesn't have to be familiar with Docker, but will certainly get more out of this talk if they have at least tried Linux Containers (through Docker or plain LXC) and have specific questions about production deployments.
Jerome is a senior engineer at Docker, where he rotates between Ops, Support and Evangelist duties. In another life he built and operated Xen clouds when EC2 was just the name of a plane, developed a GIS to deploy fiber interconnects through the French subway, managed commando deployments of large-scale video streaming systems in bandwidth-constrained environments such as conference centers, and various other feats of technical wizardry. When annoyed, he threatens to replace things with a very small shell script. His left hand cares for the dotCloud PAAS servers, while his right hand builds cool hacks around Docker.
Help us make this conference the best it can be for you. Have questions you'd like this speaker to address? Suggestions for issues that deserve extra attention? Feedback that you'd like to share with the speaker and other attendees?
Join the conversation here (requires login)
Here are the slides!
I expect that they will also be available on OSCON's website since I uploaded them there as well.
and the slides from the Tuesday 1:40pm talk. it had a lot of good examples!
Please share the slides from Sunday afternoon session
For exhibition and sponsorship opportunities, contact Sharon Cordesse at email@example.com
For information on trade opportunities with O'Reilly conferences contact firstname.lastname@example.com
For media-related inquiries, contact Maureen Jennings at firstname.lastname@example.com
View a complete list of OSCON contacts


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POTTSTOWN Ś For the second day in a row, borough residents took to the pavement to speak out against the violence which has rocked Pottstown in the past 10 days.
Numbering between 30 and 40, depending on when the counting happened, marchers walked a 10-block route, carrying signs that said simply ōStop the Violence in Pottstown.ö
Unlike MondayÆs protest outside borough hall, this time, there were no TV cameras, politicians or political agendas Ś or anyone from the previous dayÆs protest, where the ouster of Borough Council President Stephen Toroney was sought and refused.
With a few exceptions, TuesdayÆs march was mostly just mothers and grandmothers worried about their childrenÆs safety, who walked down the middle of the street shouting with the children whose safety they are trying to secure.
ōStop the violence! Do it for me,ö those children chanted as they walked with their mothers up Walnut Street from the Montgomery Elks Lodge, where they had gathered.
ōStop the violence! Do it for the children,ö the adults chanted.
Since May 30, Pottstown has seen shooting incidents near BrianÆs Cafe off North Charlotte Street, a car wash at Wilson and Spruce streets and a man shot in the elbow on Lincoln Avenue, not to mention the attempted robbery of the Wells Fargo Bank on East High Street.
Then on Thursday night, Steven Mitchell, 20, was found dead in his car in the 400 block of Jefferson Avenue, with a single gunshot to his torso.
For some, it was the breaking point, and something had to be done.
ōYou canÆt just talk, you have to take action,ö said Kendra Allen, Assistant Daughter Ruler of the Mary Esther Temple No. 917, home of Montgomery Elks Lodge No. 1271, who helped organize the march along with her cousin, Kenya Lynn Edwards, and Ayisha Quill-Harling, who had the enviable task of driving the lead (air-conditioned) vehicle that drove in front of the marchers who walked in the humidity that infused the evening.
ōWe want people to come together, we want everyone to know that weÆre not afraid,ö said Edwards.
ōSchool is about to end and we need our children to feel safe when they go to the playground,ö said Edwards. ōPeople need to feel safe when they walk to the Rite-Aid, when they walk to the RednerÆs. Things have to change.ö
For Tiffany Cuascut, 16, things have changed Ś for the worse.
She said she and her friends donÆt go out at night any more.
ōWe have to get driven everywhere we need to go,ö she said. ōIt was different when I was younger, I felt more safe.ö
ōWe need to support one another,ö said Deneen Mitchell of North Charlotte Street, who led the group in prayer before the marchers set out down Walnut Street, up to Beech Street, down Franklin Street and back on Chestnut Street.
ōThis may be a small beginning, but I think this is the start of something big,ö Mitchell said.
Allen and Edwards said the hope is for the march to spur interest in a whole series of activities all summer long, to allow children to feel safe and to show those who bring violence to PottstownÆs streets that peace-loving residents have not given up.
ōWeÆre going to do it again next week,ö said Edwards. ōNext time, weÆll have some refreshments for the kids at the park afterwards.ö
ōWe hope for the support of the community and the businesses in town as well,ö she said.
ōWe want to do things like we do in the park for the kids on Halloween, we want to play volleyball,ö said Edwards.
ōBecause people who would do violence in our community, that kind of thing makes them uncomfortable,ö she said. ōThey donÆt like to be in a place where the people are united.ö
For more information on future events, call 484-624-9393 or e-mail email@example.com or email@example.com


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STARmeterSEE RANK
Down 464,868 this week
Pauline Drewett
Pauline Drewett was born in 1943 in Surrey, Kent, England. She is an actress, known for The Belles of St. Trinian's (1954), The Gamma People (1956) and True as a Turtle (1957). She is married to David. They have two children. See full bio »
Born:in Surrey, Kent, England, UK
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Rothstein, meanwhile, asked to be kept from ever practicing law again, admitting in court documents filed Friday that there is evidence he misappropriated funds from trust accounts at his now-crumbling law firm on Las Olas Boulevard, Rothstein Rosenfeldt Adler.
- Rothstein's ex-partner Rosenfeldt a 'leader of year' before RRA collapse
- Read Rothstein's request to be forever disbarred as lawyer
- Villegas' attorneys want to depose Rothstein, Debra Villegas
- Photos: Day of reckoning arrives for Scott Rothstein
- VIDEO: Attorney Bill Scherer, who represents a dozen investors in the Rothstein meltdown, speaks to the media
- Video: Scott Rothstein scandal
The investors' lawsuit says that Linda and Doug Von Allmen and his stepson, Dean Kretschmar, bought into the scheme with assurances from TD Bank, whose executives duped them and helped Rothstein manipulate bank statements.
The RRA law firm was "the front to this elaborate Ponzi scheme,'' and TD Bank, "the financial epicenter,'' the suit filed by attorney Bill Scherer says.
It names three bank executives: Frank Spinosa, senior vice president, Jennifer Kerstetter, assistant manager, and Roseanne Caretsky, assistant vice president and branch manager. All three met with investors, verified account statements and provided "lock letters'' securing funds, the suit alleges.
TD Bank spokeswoman Rebecca Acevedo said the bank denies the lawsuit's claims.
"The claims are solely allegations and not evidence of any wrongdoing on the part of TD Bank,'' she said. "Through the legal process, the facts will prove that the Bank did not conspire with Mr. Rothstein and/or his firm. TD Bank will defend against all such unfounded claims. The Bank has and will continue to cooperate in an open and transparent manner, consistent with the law, with all governmental authorities and court orders.''
Scherer's suit says the alleged scheme could not have occurred without "insider help'' and names three of Rothstein's co-workers at RRA: David Boden, general counsel and "Rothstein's right-hand man,'' who recruited investors and drafted documents; Debra Villegas, chief operating officer and "Rothstein's Number 2,'' who supplied false bank account statements and wire transfers; and Andrew Barnett, director of corporate development, who solicited investors. Barnett's mother is an investor who says she lost $500,000.
Also named: Frank Preve, an employee of Banyon Income Fund, who had an office at the firm. Banyon brought in Von Allmen and other investors.
Attorney David Vinikoor said his client, Boden,"had no actual or constructive knowledge of any Ponzi scheme. He never solicited anyone to invest in any structured settlements. He was deceived just like many others.''
The scheme hinged on legal settlements Rothstein said his firm had reached, primarily in labor and whistle-blower cases.
Rothstein boasted of in-house private investigators, including ex- FBI and CIA agents, who secured incriminating evidence against high-profile people accused of sexual harassment or corporate wrongdoing. To avoid the negative publicity of a lawsuit, they would agree to a confidential settlement paid out over time.
The accusers wanted their money up front and agreed to a lesser amount. The investors funded those payments and then collected the full settlement amount from Rothstein.
While many of the settlements never existed, some were based on actual cases handled by Rothstein's firm, including one against Palm Beach County billionaire financier Jeffrey Epstein, a convicted sex offender accused of luring teenage girls to his mansion for erotic massages and sex acts.
The firm did represent one of Epstein's victims, but Rothstein is accused of creating a fictional victim.
The lawsuit includes an Oct. 6 e-mail from Rothstein to a hedge fund operator, pitching an investment on the case.
"It involved a horrific sexual assault against a girl that just turned 18. She was a minor when the attack occurred,'' Rothstein wrote. "She is giving up huge money as she wants the attacker out of her life. She and her mom are moving the minute she gets her money.''
He described the investment in abbreviations that appear to mean that for $18 million, the investor would earn $12 million in six months.
"Let me know,'' Rothstein wrote, signing the e-mail: "Ciao ciao, Money never sleeps mother f-----.''
The lawsuit alleges that TD Bank either participated in the scheme or is guilty of negligence for the "red flags'' Rothstein's activities should have raised.
In October alone, more than $230 million moved through the law firm's trust accounts, "more money than most banks branches would likely see in a decade,'' the suit says.
Bank executives helped Rothstein defraud investors by providing statements showing account balances that did not exist and "lock letters'' confirming that money could only be paid out to the investor's account, the suit alleges.
Spinosa, Kerstetter and Caretsky "physically handed the trust account statement to Rothstein'' in front of investors on "numerous occasions,'' the suit says.
Spinosa was seen lunching with Rothstein at his Bova restaurant on Oct. 26, the day before he fled to Morocco. At the lunch, investor Richard Pearson confronted Rothstein about why he had not received two payments scheduled to be made the previous week, Scherer said.
"Rothstein attempted to diffuse the situation leaving Spinosa visibly shaken,'' the suit says.
Rothstein then drained the TD Bank accounts and wired $16 million to a Moroccan bank, the lawsuit alleges.
Spinosa's lawyer, Sam Rabin of Miami, was not immediately available to comment. Spinosa has been on leave from the bank, pending an internal investigation.
The now-disgraced Rothstein asked to be permanently disbarred in documents filed Friday with the Florida Supreme Court.
Among the possible Florida Bar rules he admits that he may have violated: committing a criminal act that reflects badly on his honesty, trustworthiness or fitness as a lawyer; failing to comply with trust accounting requirements; and failing to hold clients' funds or properties separate from his own funds.
Richard B. Marx, a Miami attorney who specializes in Florida Bar disciplinary cases, said Rothstein's decision to give up his law license is a pretty typical response from an attorney facing such serious criminal allegations.
"He's got enough to worry about without fighting the Florida Bar, and he might be best concentrating his efforts on fighting the criminal charges."
Rothstein's law firm continues its downward trajectory.
Herbert Stettin, the former Miami-Dade judge who was already serving as receiver for the firm, was formally appointed the Chapter 11 bankruptcy trustee on Friday. He will oversee the liquidation of RRA.
Sally Kestin can be reached at email@example.com, or 954-356-4510.


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|By PR Newswire
Article Rating:
|January 7, 2013 08:01 AM EST
BEACHWOOD, Ohio, Jan. 7, 2013 /PRNewswire/ -- DDR Corp. (NYSE: DDR) today highlighted 2012 execution of strategic objectives and released guidance for 2013. During 2012 the Company significantly improved the quality of its portfolio through the acquisition of $2.1 billion of prime shopping centers ($760 million at DDR's share) and the disposition of $347 million of non-prime operating assets ($143 million at DDR's share). Investments in 2012 were funded primarily with proceeds from asset sales and $511 million of new common equity issued throughout the year, which significantly improved the Company's balance sheet as well. DDR's considerable progress in recent years recycling capital, growing its high quality pool of unencumbered prime shopping centers, lowering leverage and extending debt duration combined with strong operating results contributed to Standard & Poor's upgrade of the Company's corporate bond rating to BBB- in September and Moody's affirming its investment grade rating on DDR bonds and raising its credit outlook to positive from stable. Additionally, DDR retired $969 million of consolidated debt with a weighted average interest rate of 4.8% during the year with $1.2 billion of new long-term financings with a weighted average interest rate of 3.8%. As a result, the Company has no unsecured debt maturities until May 2015, and 2013 consolidated debt maturities are only $41 million. At year-end, the Company had over $600 million of availability under its revolving credit facilities.
(Logo: http://photos.prnewswire.com/prnh/20110912/CL65938LOGO )
The Company's operating platform continued to perform at a very high level in 2012, reporting solid improvements in leased rate, which reflect robust demand and stronger competition for quality space from retailers. During the year, the Company leased approximately 11.3 million square feet, representing a 60 basis point improvement in the leased rate over year end 2011, and resulting in a 94.2% leased rate at December 31, 2012.
Daniel B. Hurwitz, chief executive officer, commented, "2012 was another year of successful execution of our strategic objectives. We have positioned the Company for future growth with attractive investments, and our primary tenants continue to increase market share and have a significant need for new stores. With a dramatically improved portfolio of high quality prime power centers, a unique and proven operating platform, and a competitive cost of capital, we expect to generate strong relative total returns in 2013 and beyond."
In 2012, the Company completed approximately $4.5 billion of capital transactions and consolidated financing activities including the following:
- Completed $2.1 billion of acquisitions of prime shopping centers and $347 million of dispositions of non-prime operating assets. DDR's share of 2012 acquisitions was $760 million and dispositions was $143 million. In addition, the Company sold $107 million of non-income producing assets during the year, of which DDR's share was $96 million.
- Issued $511 million of common equity to fund the net investment in prime shopping centers while also increasing our pool of unencumbered assets and improving leverage metrics.
- Issued $200 million, 6.5% Class J preferred stock to redeem $170 million, 7.5% Class I preferred stock.
- Issued $450 million, 10-year, 4.625% senior unsecured notes ($300 million, June 2012; and $150 million, 3.46% yield-to-maturity, November 2012), with net proceeds used to redeem $224 million, 5.375% notes maturing October 2012 and repay borrowings under the revolving credit facility.
- Closed on $350 million unsecured term loan ($300 million, 7-year tranche, with interest fixed at 3.6% for $200 million and 3.0% for $100 million; and $50 million, 5-year tranche, with interest fixed at 2.3%), with proceeds used to retire $180 million of convertible notes, refinance a portion of our 5.0% rate mortgage debt maturing in 2013, and reduce the outstanding balances under the revolving credit facilities.
- Closed $103 million 7-year, 3.40% mortgage loan secured by three prime shopping centers in Atlanta, GA, Princeton, NJ and San Antonio, TX.
- Closed $265 million, 7-year, 3.95% mortgage loan secured by four prime shopping centers in San Juan, PR, Atlanta, GA, Miami, FL, and Columbus, OH. The proceeds from the loan were used to repay a majority of $350 million in 5.0% rate mortgage debt set to mature in April 2013.
- Extended the weighted average maturity of consolidated debt from 4.3 years to 5.1 years.
- Paid cash dividends of $0.48 per common share, an increase of 118% from 2011.
The Company also achieved the following operational accomplishments in 2012:
- Leased approximately 11.3 million square feet of gross leasable area.
- Increased portfolio leased rate to 94.2%, up 60 basis points from 93.6% at year-end 2011 and up 100 basis points when adjusting for the Blackstone acquisition.
- Increased the percentage of net operating income (NOI) generated from the prime portfolio to approximately 89.3%.
- Generated full year same store NOI growth in excess of 3%.
2013 Guidance
The Company expects to generate operating FFO per diluted share of $1.07 - $1.11 in 2013, an increase of 5% to 9% over the midpoint of the latest 2012 guidance. Significant activity assumed in this guidance is as follows:
- Generate same store NOI growth of 2.0% - 3.0%, weighted to the second half of the year.
- Increase year-end portfolio leased rate by 80 basis points, resulting in a leased rate of 95%.
- Acquire $250 million of prime shopping centers.
- Dispose of $150 million of non-prime operating assets.
- Dispose of $50 million of non-income producing assets.
- Bring at least $75 million of opportunistic development and redevelopment investment on line, primarily in the second half of the year.
- Approximately $80 million in aggregate general and administrative expenses.
- Exchange rate of 2.0 Brazilian Real per U.S. Dollar.
- Opportunistic capital raising activity to improve liquidity, further extend debt duration and improve credit metrics.
- Annual dividend of $0.54 per common share, representing 12.5% growth from the annual common share dividend of $0.48 per share in 2012.
About DDR
DDR is an owner and manager of 459 value-oriented shopping centers representing 116 million square feet in 39 states, Puerto Rico and Brazil. The company's assets are concentrated in high barrier-to-entry markets with stable populations and high growth potential and its portfolio is actively managed to create long-term shareholder value. DDR is a self-administered and self-managed REIT operating as a fully integrated real estate company, and is publicly traded on the New York Stock Exchange under the ticker symbol DDR. Additional information about the company is available at www.ddr.com.
Safe Harbor
DDR considers portions of the information in this press release to be forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, both as amended, with respect to the Company's expectation for future periods. Although the Company believes that the expectations reflected in such forward-looking statements are based upon reasonable assumptions, it can give no assurance that its expectations will be achieved. For this purpose, any statements contained herein that are not historical fact may be deemed to be forward-looking statements. There are a number of important factors that could cause our results to differ materially from those indicated by such forward-looking statements, including, among other factors, local conditions such as oversupply of space or a reduction in demand for real estate in the area; competition from other available space; dependence on rental income from real property; the loss of, significant downsizing of or bankruptcy of a major tenant; constructing properties or expansions that produce a desired yield on investment; our ability to buy or sell assets on commercially reasonable terms; our ability to complete acquisitions or dispositions of assets under contract; our ability to secure equity or debt financing on commercially acceptable terms or at all; our ability to enter into definitive agreements with regard to our financing and joint venture arrangements or our failure to satisfy conditions to the completion of these arrangements; and the success of our capital recycling strategy. For additional factors that could cause the results of the Company to differ materially from those indicated in the forward-looking statements, please refer to the Company's Form 10-K for the year ended December 31, 2011, as amended. The Company undertakes no obligation to publicly revise these forward-looking statements to reflect events or circumstances that arise after the date hereof.
SOURCE DDR Corp.
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Posts tagged: idaho
Maria Muldaur, of "Midnight at the Oasis" fame, has been booked into Spirit Lake's Red, Wine & Bluz Fest on Aug. 20 at 9 p.m.
Muldaur and her Red Hot Bluesiana Band be the closing act in the newly reinvigorated blues festival, which has been moved this year to Spirit Lake's City Park. The festival runs Aug. 19 and 20, noon to 11 p.m. each day.
Other bands include the Red Hot Blues Sisters, the Smokehouse Blues Band, Gary Yeoman and Voodoo Church and Big Daddy and the Blue Notes.
It's a family event; they will also host an arts and crafts fair and a kid's fair. Kids 12 and under are free.
Tickets are $31 for both days or $21 for one day, available in advance at www.spiritlakebluzfest.com.


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Panesar tweets delight at signing for Essex
Monty Panesar has taken to Twitter to express his delight at signing for Essex.
The England bowler agreed a two-year contract with the club earlier this afternoon, following a successful loan spell last season.
Excited to sign for Essex Eagles @essexcricket #cantwait #positive #excited


text:
Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
1/1 Photo of Summer Cooler Cocktail
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Oh my, this is my kind of drink!
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Midori melon liqueur
strawberry liqueur
Getting dinner on the table just got a whole lot easier.


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Hi: 23° Lo:11°
By Geoff Berkeley Thursday 22 November 2012 Updated: 23/11 10:05
A COURAGEOUS man from Warndon Villages who suffers from a rare debilitating disease is calling on people to pull on their walking boots and join him on a trek across the countryside to raise funds for charity.
Martyn Wells, 44, has set his sights on completing the 31-mile Worcestershire Way trek in June next year as he attempts to raise awareness of and generate more than £5,000 for Vasculitis UK.
The father-of-two was diagnosed with Polyarteritis Nodosa (PAN) - a form of Vasculitis - at the beginning of this year after two years of symptoms.
The disease, which affects the arteries that carry blood to the body's tissues and organs, has turned Mr Wells' world upside down.
"In the last three years I have attended hospital more than 100 times, I have seen seven different consultants and I have lost count of the number of blood tests I have had," he said.
"When the disease hits you, you feel like you have got the flu. You get aching joints, night sweats and tiredness beyond comprehension - even making a cup of tea is too much.
"But I have not let it affect me as I have always gone to work. You have to find a bit of fighting spirit."
The IT director is currently in the latter stages of six months of chemotherapy, but despite the punishing treatment he is aiming to complete the walk from Bewdley to Great Malvern next summer.
"I have put on nearly four stone since I have been on steroids, so you can see why there is motivation to do something positive about my weight," he added.
"I have always liked hiking and walking in the countryside and I thought to myself - 'that sounds like a man-size challenge', so I am going to take it on.
"But then I thought wouldn't it be good if others did it with me as they could do it for their own charity or to support Vasculitis UK."
Anyone who is interested in joining Mr Wells on the walk can visit www.justgiving.com/martynwells where people can also make a donation.
1 First glimpse of new college campus
2 Jobs boost for famous sauce factory
4 Work begins on former Russell and Dorrell site
FIFTY jobs have been created by a budget
FIRE and rescue crews came to the aid
A WITNESS has repeated his claim that William
A RUN-DOWN subway which has been blighted by
A VULNERABLE 20-year-old has been missing from Henley since Thusday ...
A TOTAL of 26 power tools worth more than £7,000 ...
A GROUP of teenagers have been arrested in connection with ...
WITNESSES are being sought following an unprovoked assault on a ...


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Vitamin E Analog α-TEA and Celecoxib Alone and Together Reduce Human MDA-MB-435-FL-GFP Breast Cancer Burden and Metastasis in Nude Mice
- Shuo Zhang,
- Karla A. Lawson,
- Marla Simmons-Menchaca,
- LuZhe Sun,
- Bob G. Sanders,
- Kimberly Kline
- … show all 6 hide
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α-TEA, a nonhydrolyzable ether analog of vitamin E (RRR-α-tocopherol), and celecoxib, a specific COX-2 inhibitor, were delivered separately or in combination to investigate their anticancer properties, using MDA-MB-435-FL-GFP human breast cancer xenografts in nude mice. Liposomal formulated α-TEA administered as an aerosol and celecoxib fed at 500 or 1250 mg/kg diet for 31 days separately or in combination significantly reduced tumor volume in comparison to control (p < 0.001 for all treatment groups). Of special note, the combinations of α-TEA + celecoxib (1250) inhibited tumor volume significantly better than either single treatment (p < 0.001 and p < 0.001). Average number of macroscopic lung metastases were significantly reduced in all treatment groups in comparison to control, with the exception of celecoxib (500). Mean numbers of microscopic lung and lymph node metastases in all treatment groups were significantly lower than control. Furthermore, the mean number of microscopic lung metastases in the α-TEA+celecoxib (1250) group were significantly lower than either separate treatment. Analyses of 5 μm tumor sections showed that all treatments, with the exception of celecoxib (500) alone, significantly enhanced apoptosis (TUNEL) and significantly decreased cell proliferation (Ki-67). α-TEA and α-TEA + celecoxib (1250) treatments significantly reduced blood vessel density (CD-31) in comparison to control. These data show promise for combination α-TEA + celecoxib chemotherapy for breast cancer.
- Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ: Cancer statistics, 2004. CA Cancer J Clin 54:8–29, 2004
- Lawson KA, Anderson K, Menchaca M, Atkinson J, Sun L, Knight V, Gilbert BE, Conti C, Sanders BG, Kline K: Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Mol Cancer Ther 2:437–444, 2003
- Shun M-C, Yu W, Gapor A, Parsons R, Atkinson J, Sanders BG, Kline K: Pro-apoptotic mechanisms of action of a novel vitamin E analog (a-TEA)and a naturally occurring form of vitamin E (d-tocotrienol)in MDA-MB-435 human breast cancer cells. Nutr Cancer 48(1):in press
- Hwang D, Scollard D, Byrne J, Levine E: Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Nat Cancer Inst 90:455–460, 1998
- Alshafie GA, Abou-Issa HM, Seibert K, Harris RE: Chlemotherapeutic evaluation of cyclooxygenase-2 inhibitor,in a rat mammary tumor model Oncol Rep 7:1377–1381, 2000
- Harris RE, Alshafie GA, Abou-Issa H, Seibert K: Chemoprevention of breast cancer in rats by Celecoxib, a cyclooxygenase-2 (COX-2)inhibitor. Cancer Res 60: 2101–2103, 2000
- Blumenthal RD, Waskewich C, Goldenberg DM, Lew W, Flefleh C, Burton J: Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. Clin Cancer Res 7: 3178–3185, 2001
- Kundu N, Fulton AM: Selective cyclooxygenase (COX)-l or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. Cancer Res 62:2343–2346, 2002
- Abou-Issa HM, Alshafie GA, Seibert K, Koki AT, Masferrer JL, Harris RE: Dose-response effects of COX-2 inhibitor, Celecoxib, on the chemoprevention of mammary carcinogenesis. Anticancer Res 21:3425–3432, 2001
- Howe LR, Subbaramaiah K, Patel J, Masferrer JL, Deora A, Hudis C, Thaler HT, Muller WJ, Du B, Brown AM, Dannenberg AJ: Celecoxib, a selective cyclooxygenase-2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. Cancer Res 62:5405–5407, 2002
- Lanza-Jacoby S, Miller S, Flynn J, Gallatig K, Daskalakis C, Masferrer JL, Zweifel BS, Sembhi H, Russo IH: The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice. Cancer Epidemiol Biomark Prev 12:1486–1491, 2003
- Chang S-H, Liu CH, Conway R, Han DK, Nithipatikom K, Trifan OC, Lane TF, Hla T: Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase-2-induced breast cancer progression. PNAS 101:591–596, 2004
- Liu XH, Rose DP: Differential expression and regulation of cyclooxygenase-1 and-2 in two human breast cancer cell lines. Cancer Res 56:5125–5127, 1996
- Cuendet M, Pezzuto JM: The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 17:109–157, 2000
- Soslow RA, Dannenberg AJ, Rush D, Woerner BM, Khan KN, Masferrer J, Koki AT:COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer 89:2637–2645, 2000
- Howe LR, Subbaramaiah RK, Brown AMC, Dannenberg AJ:Cyclooxygenase-2:a target for the prevention and treatment of breast cancer. Endocrine Relat Res 8:97–114, 2001
- Tsujii M, DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2.Cell 83:493–501, 1995
- Liu XH, Kirschenbaum A, Yao S, Lee R, Holland JF, Levine AC: Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo. J Urol 164:820–825, 2000
- Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, Edwards DA, Flickinger AG, Moore RJ, Seibert K: Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res 60:1306–1311, 2000
- Yu W, Israel K, Liao QY, Aldaz CM, Sanders BG, Kline K: Vitamin E succinate (VES)induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res 59:953–961, 1999
- Knight V, Koshkina NV, Waldrep JC, Giovanella BC, Gilbert BE: Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice. Cancer Chemother Pharmacol 44:177–186, 1999
- Koshkina NV, Kleinerman ES, Waldrep C, Jia S, Worth LL, Gilbert BE, Knight V:9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastasis in mice. Clin Cancer Res 6:2876–2880,2000
- Wang J, Sun L, Myeroff L, Wang X, Gentry LE, Yang J, Lian J, Zborowska E, Markowitz S, Willson JK, et al.: Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J Biol Chem 270:22044–22049, 1995
- Weidner N: Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147:9–19, 1995
- Chow LWC, Wong JLN, Toi M: Celecoxib anti-aromatase neoadjuvant (CAAN)trial for locally advanced breast cancer: preliminary report. J Steroid Biochem Mol Biol 86: 443–447, 2003
- Davis TW, O'Neal JM, Pagel MD, Zweifel BS, Mehta PP, Heuvelman DM, Masferrer JL: Synergy between celecoxib and radiotherapy results from inhibition of cyclooxygenase-2-derived prostaglandin E(2),a survival factor for tumor and associated vasculature. Cancer Res 64:279–285, 2004
- Chun KS, Kim SH, Song YS, Surh YJ: Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. Carcinogenesis 16:16, 2004
- Agarwal B, Swaroop P, Protiva P, Raj SV, Shirin H, Holt PR:Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells. Apoptosis 8:649–654, 2003
- Sheng GG, Shao J, Sheng H, Hooton EB, Isakson PC, Morrow JD, Coffey Jr RJ, DuBois RN, Beauchamp RD:A selective cyclooxygenase-2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology 113:1883–1891, 1997
- Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK, Levin B: The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 342:1946–1952, 2000
- Title
- Vitamin E Analog α-TEA and Celecoxib Alone and Together Reduce Human MDA-MB-435-FL-GFP Breast Cancer Burden and Metastasis in Nude Mice
- Journal
Breast Cancer Research and Treatment
Volume 87, Issue 2 , pp 111-121
- Cover Date
- 2004-09-01
- Print ISSN
- 0167-6806
- Online ISSN
- 1573-7217
- Publisher
- Kluwer Academic Publishers
- Additional Links
- Topics
- Keywords
- apoptosis
- celecoxib
- human MDA-MB-435-FL-GFP breast cancer xenografts
- Ki-67 nuclear antigen
- metastasis
- vitamin E analog α-TEA
- Industry Sectors
- Authors
- Shuo Zhang (1)
- Karla A. Lawson (1)
- Marla Simmons-Menchaca (2)
- LuZhe Sun (3)
- Bob G. Sanders (2)
- Kimberly Kline (1)
- Author Affiliations
- 1. Division of Nutrition/A2703, University of Texas at Austin, Austin, TX
- 2. School of Biological Sciences, University of Texas at Austin, Austin
- 3. University of Texas Health Science Center at San Antonio, San Antonio, TX, USA


text:
Find records of Billy Burns
Find birth, death, marriage, military, and other records of Billy C. Burns at Ancestry.com.Search for records
Biography & Family History Add details
Billy C. Burns (born 1969) was born in ca. 1969. He was born into the Burns family. He married Molly L. (Jones) Burns on February 18, 2000 in Gregg County, Texas. .
Billy C. Burns's last known residence is at Wood County, Texas.
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Possible Relatives
- Brandon L. Burns
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- Donald W. Burns
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- Douglas G. Burns


text:
Rodney Burke: Now, for the final number, John's got a card in his hand with a little rhyme on it. What is it?
John: It's from the form up a third at Hemel Hempstead.
Rodney: Oh!
John: It says, "Dear George, John, Ringo, Paul, here's hoping that you'll please us all. A beauty song and swinging voice, we leave it up to you, the choice. We think you're fab and really cool, so brighten up our lads at school." Dig this, for here's Paul, whistling "Clarabella.
Beatles Lyrics
Overview / Lyrics (see all) / Photos / Videos / News
A Little Rhyme Lyrics
- Play Video
- Correct
Rodney Burke: Now, for the final number, John's got a card in his hand with a little rhyme on it. What is it?
What's That Line? - Misheard Lyrics
Featured Video
What's That Line? - Misheard Lyrics
Music News
Enter For a Chance to WIN a Trip for Two to ACL Fest 2014!
It's a trip for two that includes airfare, accommodation, and VIP passes to weekend two of this year's ACL Fest.
15 Summer-Extending Songs To Make Labor Day Long Weekend Last Forever
Who cares that school starts next week? Summer's still around and it's not going anywhere. BLAST our playlist!
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text:
Topic: AdFreak
Adweek, YouTube Partner on Super Bowl Ad Hub Companies to collaborate on Ad Blitz gallery, fan voting following big game Sunday
Adweek and YouTube are co-hosting a Super Bowl party—one that will last for a week. As part of YouTube's fifth-annual Ad Blitz program, fans will be able to watch all of…
8 of the Most Extreme Extreme-Weather Ads From Dew typhoons to cheating spouses, ride out the storm with these foul weather ads
Friends: The megastorm is upon us. Hopefully you've all got your flashlights, water, and ammunition at the ready as Sandy bears down on our fair shores. With all the preparations…
Six Questions: Robert Dalrymple The producer behind Wednesday night's 'Funniest Commercials' special on TBS takes his six
Six Questions: Robert Dalrymple


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Mac: Spodlight 1.0 released
Kainjow, developer of the popular Pod2Go software, has announced the release of Spodlight 1.0, a new utility for Mac OS X v10.4 "Tiger" that allows you to use Apple's new Spotlight feature to search for music on your iPod. Spotlight does not search through invisible files and folders by default, but Spodlight forces it to index every file on your iPod. "Simply run the app, index your iPod, and then you can use Spotlight normally to find music on your iPod," explains the developer.
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thanks for the excellent bit of software - been trying to find something for you to use as an application icon, but still searching :)
Posted by yinyang on May 6, 2005 at 9:34 AM (CDT)
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text:
Filing Hints NCAA's Strategy In O'Bannon Appeal Q&A With AAC's Mike Aresco Wazzu Football Not Returning To Seattle In '15 UNCC Looks For Tix Sales Boost In Second Year Lawyers For O'Bannon Plaintiffs Seeking $52.4M SEC Schools Aim To Improve In-Game Experience UW To Sell Alcohol In New SRO Section Study: Most FBS Schools Lose Money On Sports College Facility Notes Maryland Adds Lifetime Scholarships For Athletes
Upcoming Conferences and Events
SBD/April 16, 2014/Colleges
Aresco Bullish On AAC's Future In Post-BCS Era Despite Less Guaranteed TV, Bowl Money
Published April 16, 2014
LOOOKING FOR SOMETHING PERMANENT: Central Florida Sports Commission President & CEO John Bisignano said that Orlando "needs to sell slightly less than 10,000 tickets per day to turn a profit" when the city hosts the AAC men's basketball tournament in '16 and '17. In Orlando, Paul Tenorio notes a large "chunk of those tickets are pre-purchased by the conference's athletic programs." City officials also said that they are "anticipating the tournament will lead to 6,000 hotel room reservations" and about $5.6M in economic impact. Aresco said that the "strong bid from the city prompted the league to agree" to the two-year deal. Aresco said, "We think it's a great place to be, it's a great destination for our fans. I think in March, people will come, obviously UCF is building its program, you have a beautiful state-of-the-art arena. ... If it goes really well, maybe our fans will want to stay here and make it a permanent home" (ORLANDO SENTINEL, 4/16).


text:
A house fire in Bellows Falls Tuesday morning.
The fire was reported on Oak Street just before 9 a.m. Multiple departments responded and were able to control the fire. The fire chief told WCAX News the building was heavily damaged.
Neighbors say the home is owned by a local construction company and was in the process of being renovated.
"It is sad. They put a lot of time and effort into it. They did a lot of work because the house was pretty rough. It looks a lot nicer, and then for this to happen it's sad. It really was," said William Hatfield, a neighbor.
According to firefighters there were no injuries. The cause of the fire is under investigation.
PO Box 4508
Burlington, VT 05406-4508
Primary Phone: 802-652-6300
Primary email: email@example.com


text:
'Cuts severely jeopardising ability to cope with floods'
Unprecedented cuts in funding are "severely jeopardising" the fire service's ability to cope with the floods effectively, the Fire Brigade Union has suggested.
Matt Wrack, FBU general secretary, said while firefighters were doing a fantastic job dealing with the crisis, a "very troubling picture" was emerging of "understaffed operations, badly equipped firefighters and inadequate training".
"Although there has been improvement in equipment after firefighters raised concerns during the 2007 floods, it seems our calls for better preparation and support have not yet been adequately addressed, with unprecedented cuts severely jeopardising our ability to cope with the floods effectively."
Mr Wrack said firefighters had a right to "expect the best levels of training, equipment and resources".
Read: Firefighters 'hit by infections and sickness' during floods


text:
Dongsoong Arts Centre
Mokkumto Gallery
Like most of the theatres in Daehangno, the art up here on the 3rd and 4th floors is on the fringe. The 4th floor also has craft.
Hakchon Green Theatre
The popular rock musical Line 1 staged here takes a satirical look at Seoul – the 'Ladies of Gangnam' song and dance routine is a...
Bap & Juk
A hearty bowl of healthy haemul juk (seafood rice porridge) is offered here, a good filler whatever the time of day. Other rice...
Dongsoong Arts Centre information
Lonely Planet review
Major theatre complex, where you can see Korean and international performance arts in a variety of genres. The centre includes a puppet theatre, smaller performances spaces and a museum devoted to kokdu (wooden dolls and effigies with spiritual properties).


text:
More Undead Hijinx Abound in Second Shouf Shouf Zombibi Trailer
We know what you're thinking ... "Damn it! We haven't had a new trailer for the foreign zombie comedy from the Netherlands, Shouf Shouf Zombibi, in months!" Okay, so maybe you weren't thinking that. Still, here's one anyway!
Shouf Shouf Zombibi is Erwin van den Eshof and Martijn Smits' new zombie comedy from the Netherlands starring Achmed Akkabi, Mimoun Ouled Radi, and Yes-R.
"The bizarre story takes place in Amsterdam-West, where a virus turns people into bloodthirsty zombies. Although much blood is flowing and many limbs chopped off, there is a lot to laugh at in this bizarre horror comedy."
Dig on the trailer below, and look for more soon!
Got news? Click here to submit it!
Start shoufing in the comments section below.


text:
The #1 source for fashion inspiration from real people around the world.
HYPE the looks you like to make them hot —or post your own! learn more or sign up now!
Something about #white screams "pulled together" and "elegant" to me. Maybe it's the extreme measures one must go to in an effort to maintain the pristine shade. I have far too many recent memories of sauces, dirt, and pen marks, so white outfits are only reserved for special events. Good thing Stephanie and I had a #DateNight planned at Dizzy's Club Coca Cola, fresh off of our trip to #Miami.
Can you tell I'm obsessed with #boohoo yet? Such pretty, flattering silhouettes in basic colors make it so easy to shop their collections. This Kiera dress is almost sold out on site, but there are tons of other beautiful bodycon options to choose from (like this, this, and this). Don't fret, #plussize honeys, their bodycon dresses are very forgiving. I usually purchase the US 10 (I'm usually a US 18).
Styling Tip: When accessorizing solid-colored pieces, keep jewelry and shoes within the same color family as the piece to create a clean aesthetic.
What have you and your best friends been doing this summer? Me and my girls have been kicking it, full throttle!
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Triple Bafta win for Argo
Argo was the big winner at the Bafta awards, scooping Best Film, Best Director for Ben Affleck and Best Editing.
Les Miserables claims Bafta for Production Design
Eve Stewart and Anna Lynch-Robinson have won the Bafta award for Production Design for their work on Les Miserables.
Searching For Sugar Man wins Bafta for Best Documentary
Searching For Sugar Man has won the Bafta award for Best Documentary.
Juno Temple wins Rising Star Award at Baftas
Actress Juno Temple has won the EE Rising Star Award - the only award that is voted for by the public.
Amour wins Bafta for Film Not in the English Language
Amour wins the Bafta award for Film Not in the English Language.
Tessa Ross wins Bafta for Outstanding British Contribution to Cinema
The Bafta award for Outstanding British Contribution to Cinema goes to producer Tessa Ross.
Danny Boyle presents Bafta award
Film and Olympic Opening Ceremony director Danny Boyle is presenting an award at the Baftas.
Danny Boyle presents tonight's BAFTA for Outstanding British Contribution to Cinema #EEBAFTAs
Silver Linings Playbook takes Bafta for Adapted Screenplay
The Bafta award for Adapted Screenplay goes to David O'Russell for his work on Silver Linings Playbook.
Anne Hathaway wins Bafta for Supporting Actress
Anne Hathaway has won the Bafta award for Supporting Actress for her role in Les Miserables.
Life Of Pi wins Bafta for Special Visual Effects
Life Of Pi has won the Bafta award for Special Visual Effects.
Tarantino thanks actors for doing a 'bang-up job'
Quentin Tarantino thanked his actors for doing a "bang-up job with my dialogue" in his acceptance speech.
His screenplay for Django Unchained has attracted criticism for its liberal use of racial insults and Tarantino thanked his backers for standing by what he described as "a hot potato" film.


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The vagueness of Indiana's meth disclosure laws caught the attention of State Rep. Wendy McNamara, a Republican from Posey County, who this month introduced a bill requiring owners to explicitly say if a house has been used in "the manufacture of methamphetamine or dumping of waste from the manufacture of methamphetamine (even if the owner does not know whether the property is contaminated)."
"My intention is to protect the public from others who don't seem to care," McNamara said in a press release.
The bill received its first reading earlier this month and was referred to the Government and Regulatory Reform Committee.
Even if the bill passes, it doesn't guarantee home buyers won't move into a residence where someone cooked or smoked meth.
Jim Horton, owner of HyTek Home Inspection in Kokomo, said checking for meth residue isn't a standard test when doing a home inspection for a buyer. He said he might suggest it if he had a strong suspicion of meth activity, but generally the owner or buyer has to specifically ask for it.
"I'm sure there's a lot of (meth use) going on, but few request to have a home tested," he said.
Amy Pate, executive vice president of the Realtors Association of Central Indiana, said area real estate agents are becoming more savvy at spotting potential meth activity in a house thanks to training offered by law enforcement agencies at Realtors' conferences.
"It's a real issue in real estate and in our community," she said. "Part of it is just making people aware of what a suspicious scenario is. A lot of people wouldn't know that a 2-liter bottle and tubing could be an issue."
Pate said if a real estate agent suspects a home has been used to cook meth, they call police.


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For a quiet meal with in the bustling city
Located at a central location yet still remaining pretty much hidden, this bakery bistro bar serves quite a variety of items on its menu. It has brunch items such as Eggs Benedict and mains that include sandwiches and pizzas.
For more, go to http://herpenandfork.blogspot.sg/2014/04/review-nassim-hill-bakery-bistro-bar.html


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My Little Pony: Friendship is Magic - Would you do the same if you were lucky enough for Rainbow Dash to have a crush on you?
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Sun-kissed skin is increasingly hard to come by now that the sun is going steady with Jupiter. Get skin worth staring directly into with this Groupon.
Choose from Three Options
- $29 for one month of unlimited level-4 UV-bed tanning (a $70 value)
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Siesta Tan
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